title: [Principles for optimizing and guaging several processes in the technology of vaccine production. II. Modeling processes of thermal inactivation of microorganisms].
abstract: The paper treats of some problems pertinent to modelling of thermal inactivation of the microbes serving as a theoretical foundation for the achievement of guaranteed sterility of the equipment, communications and fluids. The principal attention is devoted to the problems of quantitative assessment of the efficacy of the mentioned processes. The advantages and the drawbacks of some deterministic and probability models which found application in microbiological laboratories are assessed. The expediency of orientation on a model proposing the use of characteristics of thermal resistance of the microorganisms and considering the heterogeneity of the actual populations by the thermoresistance index was demonstrated.
mesh_terms: D001407:Bacillus; D003014:Clostridium botulinum; D006358:Hot Temperature; D008954:Models, Biological; D013242:Sterilization; D014612:Vaccines / Q000592:standards*
chemical_list: D014612:Vaccines
vernacular_title: Printsipy optimizatsii i masshtabirovaniia nekotorykh protsessov v tekhnologii vaktsinnykh proizvodstv. Soobshchenie II. Modelirovanie protsessov termicheskoĭ inaktivatsii mikroorganizmov.