An overlooked aspect of the mechanism of action of most antineoplastic drugs: the inhibition of macromolecular RNA metabolism.
D000970:Antineoplastic Agents / Q000494:pharmacology*; D003561:Cytarabine / Q000494:pharmacology; D004247:DNA / Q000096:biosynthesis; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000378:metabolism; D008727:Methotrexate / Q000494:pharmacology; D008970:Molecular Weight; D011687:Purines / Q000494:pharmacology; D011743:Pyrimidines / Q000494:pharmacology; D012313:RNA / Q000096:biosynthesis*; D012333:RNA, Messenger / Q000096:biosynthesis
D000970:Antineoplastic Agents; D011687:Purines; D011743:Pyrimidines; D012333:RNA, Messenger; D003561:Cytarabine; D012313:RNA; D004247:DNA; D012321:DNA-Directed RNA Polymerases; D008727:Methotrexate