title: Tissue reactions to breast implants coated with polyurethane.
abstract: The histological features noted in the capsules from 7 polyurethane coated silicone breast prostheses are described. The polyurethane provoked a definite foreign body reaction and was slowly degraded, with some particles ejected from the capsule into the surrounding tissues. Separation of the polyurethane coating from the silicone prosthesis and the degradation of the polyurethane took about two years. Another much more resistant foreign material was found to occur in conjunction with the polyurethane in the capsules. It may be an adhesive or flakes off the silicone shell. Vacuolated spaces were noted in the inner layers of 3 capsules; it was assumed that they contained liquid silicone.
mesh_terms: D001940:Breast / Q000473:pathology / Q000601:surgery*; D003238:Connective Tissue / Q000473:pathology; D005260:Female; D005549:Foreign-Body Reaction / Q000209:etiology / Q000473:pathology*; D006801:Humans; D011140:Polyurethanes / Q000009:adverse effects*; D019736:Prostheses and Implants / Q000009:adverse effects*
chemical_list: D011140:Polyurethanes