The effects of atenolol and propranolol upon lipolysis.
1 The effects of selective and non-selective beta-adrenoceptor blockade upon plasma non-esterified fatty acid concentrations in the fasting state and following insulin stress have been studied in normal subjects. 2 Atenolol, propranolol and placebo were compared in a double-blind cross-over trial in eight normal subjects. 3 Atenolol and propranolol significantly lowered plasma non-esterified fatty acid concentrations by a similar degree in the fasting, non-stressed state. This finding suggests that beta1-adrenoceptors are involved in the control of basal lipolysis. 4 Following insulin-induced stress, lower plasma non-esterified fatty acid concentrations were observed with propranolol than with atenolol. This difference may be due to beta2-adrenoceptor involvement in the stress mechanisms controlling lipolysis, or to the differences in the water-lipid solubility properties of these drugs.
D000328:Adult; D001262:Atenolol / Q000494:pharmacology*; D001786:Blood Glucose / Q000378:metabolism; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005215:Fasting; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005260:Female; D006801:Humans; D007328:Insulin / Q000494:pharmacology; D008297:Male; D010919:Placebos; D011412:Propanolamines / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology*
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D010919:Placebos; D011412:Propanolamines; D001262:Atenolol; D011433:Propranolol