H-2 effects on cell-cell interactions in the response to single non-H-2 alloantigens. I. Donor H-2D region control of H-7.1-immunogenicity and lack of restriction in vivo.
Genes in the H-2 complex regulate the relative immunogenicity of the H-7.1 histocompatibility alloantigen, as measured by survival times of H-7.1-incompatible skin grafts in vivo. The gene controlling relative rejectability of H-7.1-incompatible grafts has been mapped to the H-2D region. H-7.1-incompatible skin grafts donated by H-2Db donors were rejected significantly more rapidly by H-2a/H-2b heterozygous recipients than similar H-7.1-incompatible grafts donated by H-2Dd donors. Further, there was absolutely no evidence of H-2 restriction in cytotoxic effector activity. In vivo cross-priming, as indicated by accelerated secondary graft rejection, was extensive. The efficiency of cross-priming was dependent upon the primary and secondary graft donor H-2 haplotypes.
D000818:Animals; D002450:Cell Communication; D002874:Chromosome Mapping; D005796:Genes; D008040:Genetic Linkage; D006084:Graft Rejection; D006648:Histocompatibility; D006649:Histocompatibility Antigens; D007109:Immunity; D051379:Mice; D008815:Mice, Inbred Strains; D016038:Skin Transplantation; D014184:Transplantation, Homologous
D006649:Histocompatibility Antigens