Genetic control of lymphocyte suppression. I. Lack of suppression in aged NZB mice is due to a B cell defect.
Con A-activated cells from old NZB mice were found capable of inhibiting the polyclonal response of cells from young NZB and BALB/c animals. Furthermore, Con A-preactivated spleen cells from young NZB and BALB/c mice did not significantly affect the response of spleen cells from old NZB mice. These results suggest that the defective suppressive activity in old NZB mice may be traced to a defect at the B cell level.
D000375:Aging; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D003208:Concanavalin A / Q000494:pharmacology; D004306:Dose-Response Relationship, Immunologic; D005796:Genes; D006462:Hemolytic Plaque Technique; D007116:Immunization, Passive; D051379:Mice; D008807:Mice, Inbred BALB C; D008814:Mice, Inbred NZB; D013601:T-Lymphocytes / Q000276:immunology*
D003208:Concanavalin A