title: [Ampicillin concentration in the blood when administered by jet injection and needle-syringe methods].
abstract: The studies were carried out on 50 persons. Ampicillin was administered with the help of a jet injector B1-2 and needle syringe in doses of 250 or 500  and 500 mg respectively. When the drug was administered by infusion, its maximum blood levels were achieved earlier than after needle-syringe administration of the drug and were higher (22.83+/-4.10 and 6.3+/-0.09 gamma/ml respectively). Even when ampicillin was administered with the help of the injector in a dose of 250 mg its blood levels were much higher than those after needle-syringe administration in a dose of 500 mg. After jet infusion the prolongation of the drug retention time in the blood at therapeutical levels was observed as compared to the needle-syringe administration.
mesh_terms: D000328:Adult; D000667:Ampicillin / Q000008:administration & dosage* / Q000097:blood; D001702:Biopharmaceutics; D002986:Clinical Trials as Topic; D006801:Humans; D007277:Injections, Jet; D008875:Middle Aged; D013594:Syringes; D013997:Time Factors
chemical_list: D000667:Ampicillin
vernacular_title: Kontsentratsiia amptisillina v krovi pri bezygol'nom struĭnom i igol'no-shpritsevom sposobakh vvedeniia.