title: Plasma concentrations of diazepam and desmethyldiazepam during chronic diazepam therapy.
abstract: 1 Plasma concentrations of diazepam and its metabolite, desmethyldiazepam, have been measured in both in- and out-patient groups treated with diazepam for periods varying between 1 month and 10 years. 2 The diazepam concentration was directly related to the dose of diazepam ingested and inversely related to the age of the patient. 3 A highly significant relationship was obtained between the concentration of desmethyldiazepam and diazepam. 4 The plasma concentrations of both diazepam and its metabolite were independent of sex, duration fo therapy and patient group.
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D003975:Diazepam / Q000031:analogs & derivatives* / Q000097:blood* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D003708:Nordazepam / Q000097:blood*; D012737:Sex Factors; D013997:Time Factors
chemical_list: D003708:Nordazepam; D003975:Diazepam