Thrombin, collagen and A23187 stimulated endogenous platelet arachidonate metabolism: differential inhibition by PGE1, local anesthetics and a serine-protease inhibitor.
D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001095:Arachidonic Acids / Q000097:blood* / Q000494:pharmacology; D001792:Blood Platelets / Q000378:metabolism*; D000001:Calcimycin / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D002118:Calcium / Q000097:blood; D003094:Collagen / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D006801:Humans; D008314:Malonates / Q000096:biosynthesis*; D008315:Malondialdehyde / Q000096:biosynthesis*; D010101:Oxygen Consumption / Q000187:drug effects; D010664:Phenylmethylsulfonyl Fluoride / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D011458:Prostaglandins E / Q000494:pharmacology*; D011817:Rabbits; D013450:Sulfones / Q000494:pharmacology*; D013806:Theophylline / Q000494:pharmacology; D013917:Thrombin / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D013928:Thromboxane A2 / Q000096:biosynthesis*; D013931:Thromboxanes / Q000096:biosynthesis*
D000779:Anesthetics, Local; D000900:Anti-Bacterial Agents; D001095:Arachidonic Acids; D008314:Malonates; D011458:Prostaglandins E; D013450:Sulfones; D013931:Thromboxanes; D000001:Calcimycin; D008315:Malondialdehyde; D013928:Thromboxane A2; D010664:Phenylmethylsulfonyl Fluoride; D003094:Collagen; D013806:Theophylline; D013917:Thrombin; D002118:Calcium