Immunosuppressive effect of human pregnancy zone protein on H-2 incompatible mouse heart allografts.
Human pregnancy zone protein (PZP) given intraveneously, significantly (p less than 0.001) prolonged the survival of heterotopic A/J heart transplants in A.CA recipients, compared to untreated control recipients, recipients treated with phosphate buffered saline and recipients treated with a control preparation from male serum. The results support the hypothesis that PZP protein exerts an unspecific immunosuppressive effect in vivo.
D000818:Animals; D001798:Blood Proteins / Q000276:immunology*; D005260:Female; D006085:Graft Survival; D006183:H-2 Antigens; D016027:Heart Transplantation; D006801:Humans; D007106:Immune Sera; D007166:Immunosuppressive Agents; D007275:Injections, Intravenous; D051379:Mice; D011247:Pregnancy; D014184:Transplantation, Homologous
D001798:Blood Proteins; D006183:H-2 Antigens; D007106:Immune Sera; D007166:Immunosuppressive Agents