title: [Dynamic study of the hypothalomo-hypophyseal-gonadal axis in patients with Klinefelter's syndrome].
abstract: Detailed clinical and hormonal studies were performed in 30 male patients with Klinefelter syndrome, proved by karyotyping. Diagnostic tests with LH-RH were carried out with application of 100 microgram of LH-RH as single stimulation and as long-term application for 7 days. Plasma levels of LH, FSH and testosterone were measured by specific radioimmunoassay. Th single LH-RG application stimulated both LH and FST secretion, while testosterone level remained unchanged in patients with Klinefelter syndrome. Long-term stimulation decreased basal LH and FSH levels and pituitary response to LH-RH . became close to normal. The testosterone level increased significantly in most patients with Klinefelter syndrome. This suggests that the Leydig cells in Klinefelter syndrome improved their activity, showing some functional reserve.
mesh_terms: D000293:Adolescent; D000328:Adult; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D007621:Karyotyping; D007713:Klinefelter Syndrome / Q000503:physiopathology*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D013737:Testis / Q000503:physiopathology*; D013739:Testosterone / Q000097:blood
chemical_list: D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
vernacular_title: Dinamichno izsledvane na khipotalamo-khipofizo-gonadnata os pri bolni s Klaĭnfeltur sindrom.