[Drug-induced oesophageal ulcers (author's transl)].
Within a one-year period seven patients were observed who had developed ulcers of the upper and mid oesophagus after treatment with doxycycline hydrochloride (n = 3), emepronium bromide (n = 3) or Pantogar (n = 1). In each instance the drug had apparently been swallowed dry. The typical symptoms were a sudden onset of retrosternal chest pain and odynophagia during bed rest. Once the drug had been discontinued and treatment with antacid combined with topical anaesthetics and/or alginic acid instituted the symptoms disappeared within a few days. The authors stress that drugs should be swallowed only with good amounts of fluid and generally not immediately before bed rest.
D010129:4-Aminobenzoic Acid / Q000009:adverse effects; D000328:Adult; D003553:Cystine / Q000009:adverse effects; D004318:Doxycycline / Q000009:adverse effects; D004629:Emepronium / Q000009:adverse effects; D004935:Esophageal Diseases / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007633:Keratins / Q000009:adverse effects; D008297:Male; D010205:Pantothenic Acid / Q000009:adverse effects; D012440:Saccharomyces; D012441:Saccharomyces cerevisiae; D013831:Thiamine / Q000009:adverse effects; D014456:Ulcer / Q000139:chemically induced*
D004629:Emepronium; D010205:Pantothenic Acid; D003553:Cystine; D007633:Keratins; D004318:Doxycycline; D010129:4-Aminobenzoic Acid; D013831:Thiamine
Medikamentös induzierte Osophagusulzera.