title: Presence and activity of LH-RH in the mid-term human fetus.
abstract: Immunoreactive LH-RH was present in all the hypothalamic and cortical extracts of mid-term human fetuses studied and in the cortical tissue removed from the two youngest fetuses. Gonadotrophin-releasing activity of hypothalamic and cortical extracts was demonstrated by the significant rises of circulating LH after infusion into oestrogen and progesterone-primed ovariectomized rats.
mesh_terms: D000367:Age Factors; D000818:Animals; D002369:Castration; D002540:Cerebral Cortex / Q000196:embryology* / Q000378:metabolism; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans; D007031:Hypothalamus / Q000196:embryology* / Q000378:metabolism; D007986:Luteinizing Hormone / Q000097:blood; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D051381:Rats; D014020:Tissue Extracts / Q000494:pharmacology
chemical_list: D014020:Tissue Extracts; D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone