Suppression of humoral and delayed hypersensitivity responses by distinct T cell subpopulations.
Immunization of mice with a supraoptimal dose of sheep red blood cells (SRBC) results in splenic T cell populations capable of specifically suppressing recipients' plaque forming cell (PFC) and delayed-type hypersensitivity (DTH) responses to SRBC when tested in an adoptive transfer system. By localization on discontinuous bovine serum albumin (BSA) gradients and relative sensitivity to Cytoxan, two distinct T cell subpopulations suppressing DTH reactivity were identified. One population could not be distinguished from T cells capable of inhibiting direct and indirect PFC responses. However, another population appeared quite distinct and capable of inhibiting DTH, but not PFC responses.
D000818:Animals; D002469:Cell Separation; D002499:Centrifugation, Density Gradient; D010856:Columbidae; D003520:Cyclophosphamide / Q000494:pharmacology; D004912:Erythrocytes / Q000276:immunology; D006462:Hemolytic Plaque Technique; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D007109:Immunity; D007165:Immunosuppression Therapy; D051379:Mice; D008809:Mice, Inbred C3H; D012756:Sheep; D013601:T-Lymphocytes / Q000276:immunology / Q000528:radiation effects
D003520:Cyclophosphamide