A double blind study with melperone and placebo in the treatment of chronic alcoholics.
In a 2-wk randomized double blind study 60 chronic alcoholics were treated with either melperone (Buronil) or placebo. The patients were assessed daily using a scale including 4 items: tension, depression, craving and sleep. Statistically significant improvement was achieved in the placebo group only for "tension" and "sleep"; whereas, in the melperone group all four items improved significantly. Comparison between the groups revealed statistically significant superiority of melperone over placebo for the item "craving".
D000328:Adult; D000437:Alcoholism / Q000188:drug therapy*; D002090:Butyrophenones / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003863:Depression / Q000188:drug therapy; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D008875:Middle Aged; D010880:Piperidines / Q000627:therapeutic use; D010919:Placebos; D012890:Sleep; D011795:Surveys and Questionnaires
D002090:Butyrophenones; D010880:Piperidines; D010919:Placebos; C008522:metylperon