Acid secretion and cyclic nucleotide content of the guinea pig isolated stomach in the presence of the ionophore A23187.
The involvement of calcium ions in stimulus-secretion coupling in the gastric mucosa is uncertain. Acid secretion and mucosal cyclic nucleotide content of an isolated stomach preparation from the guinea-pig have been measured in the presence of the ionophore A2318 (Lilly) over the concentration range 10(-6) M both in the presence and absence of a phosphodiesterase inhibitor (ICI 631978 1 X 10(-4) M). The rate of acid secretion and cyclic nucleotide content were increased by ICI 63197 as expected but were unaltered by the ionophore. These results suggest that a change in intracellular calcium ion concentration does not alter acid secretion in this preparation.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000001:Calcimycin / Q000494:pharmacology*; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000032:analysis / Q000378:metabolism*; D006168:Guinea Pigs; D009712:Nucleotides, Cyclic / Q000032:analysis*; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology*; D012636:Secretory Rate / Q000187:drug effects; D013268:Stimulation, Chemical
D000900:Anti-Bacterial Agents; D009712:Nucleotides, Cyclic; D010726:Phosphodiesterase Inhibitors; D000001:Calcimycin