Factors influencing susceptibility of Nocardia species to trimethoprim-sulfamethoxazole.
Demonstration of synergism between trimethoprim and sulfamethoxazole against 10 Nocardia isolates was found to be critically dependent upon the isolate, the duration of incubation, and the trimethoprim-sulfamethoxazole ratio. Inoculum effect was not significant. The trimethoprim-sulfamethoxazole ratio in the commercial, fixed-dose combination was found to contain too little trimethoprim to be optimal for Nocardia.
D004338:Drug Combinations; D004357:Drug Synergism; D006801:Humans; D008826:Microbial Sensitivity Tests; D009615:Nocardia / Q000187:drug effects*; D009617:Nocardia Infections / Q000382:microbiology; D009616:Nocardia asteroides / Q000187:drug effects; D013420:Sulfamethoxazole / Q000494:pharmacology*; D014295:Trimethoprim / Q000494:pharmacology*
D004338:Drug Combinations; D014295:Trimethoprim; D013420:Sulfamethoxazole