title: [Microcalorimetric Investigations, regarding the antibacterial efficiency of chemotherapeutics (author's transl)].
abstract: An investigation method is described by which microcalorimetry and continuous density measurement are used to show the antibacterial efficiency of chemotherapeutics. Oleandomycin, erythromycin, both macrolide antibiotics, and doxycycline, a tetracycline, blockers of the protein synthesis, have the same effect on the microcalorimetric curve of a staphylococcus strain. Among the aminoglycosides tobramycin and gentamicin influenced the microcalorimetric activity of a growing E. coli strain in the same way, spectinomycin produced different curves. Penicillins interfere with the synthesis of the cell membrane by blocking the enzyme transpeptidase. Epicillin, penicillin, ampicillin, oxacillin, carbenicillin, and azlocillin influence the microcalorimetric activity of staphylococci in a typical way which is different from that of the blockers of the protein synthesis.
mesh_terms: D000617:Aminoglycosides / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001426:Bacterial Proteins / Q000096:biosynthesis; D002151:Calorimetry; D004318:Doxycycline / Q000627:therapeutic use; D004917:Erythromycin / Q000627:therapeutic use; D004926:Escherichia coli / Q000187:drug effects; D009391:Nephelometry and Turbidimetry; D009827:Oleandomycin / Q000627:therapeutic use; D010406:Penicillins / Q000627:therapeutic use; D010458:Peptidyl Transferases / Q000037:antagonists & inhibitors; D013210:Staphylococcus / Q000378:metabolism
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D010406:Penicillins; D004917:Erythromycin; D010458:Peptidyl Transferases; D004318:Doxycycline; D009827:Oleandomycin
vernacular_title: Mikrokalorimetrische Untersuchungen zur Charakterisierung der antibakteriellen Wirksamkeit von Chemotherapeutika.