Aprindine.
Aprindine is a long-acting antiarrhythmic agent, effective when administered orally or intravenously in the treatment of ventricular arrhythmias of varying etiologies. It may be especially useful in the treatment of the Wolff-Parkinson-White syndrome. To a lesser extent, it may be useful in the treatment of atrial arrhythmias. Side effects can be minimized by careful titration of the dose of aprindine. If the frequency of such serious side effects as cholestatic jaundice and agranulocytosis remains low enough, aprindine should prove to be a useful addition to currently available antiarrhythmic drugs.
D000284:Administration, Oral; D000380:Agranulocytosis / Q000139:chemically induced; D000818:Animals; D001073:Aprindine / Q000008:administration & dosage / Q000009:adverse effects / Q000378:metabolism / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy*; D001341:Autonomic Nervous System / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects; D056486:Chemical and Drug Induced Liver Injury; D004064:Digestive System / Q000187:drug effects; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D006329:Heart Conduction System / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007192:Indenes / Q000627:therapeutic use*; D007263:Infusions, Parenteral; D008099:Liver / Q000378:metabolism; D009422:Nervous System Diseases / Q000139:chemically induced; D014927:Wolff-Parkinson-White Syndrome / Q000188:drug therapy
D007192:Indenes; D001073:Aprindine