title: [Nomifensine: clinical data (author's transl)].
abstract: Open studies with nomifensine the placebo, and double-blind controlled comparisons of nomifensine with placebo, imipramine, amitriptyline, nortriptyline... have been carried out in various parts of the world. Daily dosage varied (50-225 mg), lenght of treatment also (226 weeks). These trials showed considerable effectiveness of nomifensine in neurotic and reactive depressions, it counteracts inhibition and restores drive. Nomifensine caused no significant cardiovascular or anticholinergic side-effects. It does not potentiate the effect of alcohol.
mesh_terms: D000275:Adjustment Disorders / Q000188:drug therapy*; D000928:Antidepressive Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D006801:Humans; D007546:Isoquinolines / Q000627:therapeutic use*; D009627:Nomifensine / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D000928:Antidepressive Agents; D007546:Isoquinolines; D009627:Nomifensine
vernacular_title: La nomifensine. Données cliniques.