title: A syndrome from a possible GABA deficiency. Clinical-therapeutic report on 15 cases.
abstract: A detailed presentation of 15 case-histories of subjects of both sexes, drawn from all decennies of life from the first to the eight, suggesting a syndrome originated from a possible GABA deficiency, is carefully made. Such syndrome is believed to be characterized by basic depressive state, loss of the habit of stretching oneself, sleep disorders, mostly with early morning awakening, constipation and nuchal headache. The above symptoms have been associated to a deficiency of GABA after noting the very speed recovery after administration of N-dipropylacetic acid, an inhibitor of GABA transaminase.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000613:Aminobutyrates / Q000172:deficiency*; D002648:Child; D003248:Constipation / Q000188:drug therapy / Q000378:metabolism; D005260:Female; D018756:GABA Antagonists; D006261:Headache / Q000188:drug therapy / Q000378:metabolism; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000188:drug therapy / Q000378:metabolism*; D008875:Middle Aged; D012893:Sleep Wake Disorders / Q000188:drug therapy / Q000378:metabolism; D014631:Valerates / Q000627:therapeutic use*; D014635:Valproic Acid / Q000627:therapeutic use*; D005680:gamma-Aminobutyric Acid / Q000172:deficiency*
chemical_list: D000613:Aminobutyrates; D018756:GABA Antagonists; D014631:Valerates; D005680:gamma-Aminobutyric Acid; D014635:Valproic Acid