title: Dose response to intramuscular glucagon during hypotonic radiography.
abstract: In a study to determine a dose response to glucagon during hypotonic duodenography, 15 male and female volunteers received placebo and 0.25 mg 1 mg and 2 mg glucagon intramuscularly, double-blind and cross-over. When 0.25 mg glucagon was given, the onset of drug effect was approximately 13--18 min: the mean duration of moderate hypotonicity was approximately 4--7 min. The larger the dose, the greater the duration of drug action. When 2 mg glucagon was given, the onset of drug effect occurred in approximately 4--7 min; the mean duration of moderate hypotonicity was 22--32 min. There were no changes in pulse or blood pressure attributable to the drug with these doses, and reports of nausea and diarrhea did not increase significantly until a dose above 1 mg was given. One mg glucagon given IM is useful in hypotonic upper Gl radiographic examinations. The onset of hypotonicity was 8--10 min with a duration of 12--27 min when this dose was given. Few reports of side effects were attributable to this dose.
mesh_terms: D000328:Adult; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004386:Duodenum / Q000000981:diagnostic imaging* / Q000187:drug effects; D005260:Female; D005934:Glucagon / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D006801:Humans; D007263:Infusions, Parenteral; D007273:Injections, Intramuscular; D007421:Intestine, Small / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009129:Muscle Tonus / Q000187:drug effects*; D010919:Placebos; D011859:Radiography; D013270:Stomach / Q000187:drug effects
chemical_list: D010919:Placebos; D005934:Glucagon