Maximal exercise test in patients with essential hypertension treated with propranolol.
Maximal exercise test was performed in 15 patients with essential hypertension before and after 10 days of treatment with oral propranolol in daily doses of 320 mg. After the treatment, heart rate, and systolic and diastolic blood pressure significantly fell both at rest and after the test; a greater, though not significantly, workload was tolerated; a significant decrease was observed in the product of heart rate and systolic blood pressure, together with a marked reduction in electrocardiographic ischemic changes. Propranolol treatment, besides being an effective antihypertensive agent, improved ischemic changes induced by exercise and cardiac performance in hypertensive patients, also in the presence of left ventricular hypertrophy.
D000328:Adult; D000787:Angina Pectoris / Q000150:complications; D002986:Clinical Trials as Topic; D003327:Coronary Disease / Q000150:complications; D005080:Exercise Test; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption / Q000187:drug effects; D011433:Propranolol / Q000008:administration & dosage*
D011433:Propranolol