title: Scleroderma: pathogenic factors and current management.
abstract: The aetiology of scleroderma remains unknown. Pathogenetic mechanisms may originate from vascular, collagen or immune abnormalities. These are reviewed and the current management although in the main unsatisfactory may alleviate a number of the distressing symptoms.
mesh_terms: D001808:Blood Vessels / Q000473:pathology / Q000503:physiopathology; D001809:Blood Viscosity; D003094:Collagen / Q000378:metabolism; D006801:Humans; D008833:Microcirculation; D012595:Scleroderma, Systemic / Q000209:etiology* / Q000276:immunology / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D012867:Skin / Q000378:metabolism / Q000473:pathology
chemical_list: D003094:Collagen