An immunisation model for the control of infectious enteritis.
An intestinal immunisation procedure involving systemic priming and oral boosting was investigated in lambs with a view to providing vaccination control of enteritis in young animals. The procedure stimulated the appearance of antibody-containing cells of IgA specificity in the intestine and lambs immunised in this way with a bacterial vaccine were protected against subsequent challenge with live enteropathogenic bacteria. This immunisation regime therefore provides a useful method for the stimulation of IgA immunity in the intestine of ruminants and it is anticipated that it will have general application to a variety of enteric diseases.
D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D001424:Bacterial Infections / Q000517:prevention & control / Q000662:veterinary*; D004751:Enteritis / Q000517:prevention & control / Q000662:veterinary*; D005260:Female; D007114:Immunization / Q000662:veterinary*; D007115:Immunization Schedule; D008954:Models, Biological; D010047:Ovalbumin / Q000276:immunology; D012481:Salmonella Infections, Animal / Q000517:prevention & control; D012486:Salmonella typhimurium / Q000276:immunology; D012756:Sheep; D012757:Sheep Diseases / Q000517:prevention & control
D000907:Antibodies, Bacterial; D010047:Ovalbumin