Comparative assessment of fenoprofen and paracetamol given in combination for pain after surgery.
In a double-blind study of patients suffering from pain after surgery, fenoprofen 200 mg and paracetamol 500 mg was compared with each drug given separately and with a placebo. There was a significant difference between the combination and the placebo, whereas, separately, the drugs were only marginally better than the placebo in relieving pain. There was a significant linear trend indicating a better clinical result as the number of active components in the regimen was increased.
D000082:Acetaminophen / Q000008:administration & dosage / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D005279:Fenoprofen / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010149:Postoperative Pain / Q000188:drug therapy*; D010666:Phenylpropionates / Q000627:therapeutic use*; D013997:Time Factors
D010666:Phenylpropionates; D000082:Acetaminophen; D005279:Fenoprofen