Uptake of 2'-amino-2'-deoxyguanosine by Escherichia coli and its competition by guanosine.
The antibacterial activity of a new nucleoside antibiotic, 2'-amino-2'-deoxyguanosine (2AG), is reversed by guanosine and other purine nucleosides. 2AG is apparently taken up by E. coli by a mechanism different from that of guanosine; guanosine inhibits this uptake non-competitively. Insensitive E. coli strains and the resistant mutant obtained from the sensitive strain also took up 2AG.
D001667:Binding, Competitive; D003470:Culture Media; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D006151:Guanosine / Q000378:metabolism*; D007700:Kinetics
D003470:Culture Media; D006151:Guanosine; D003849:Deoxyguanosine