[The effect of piracetam on global and regional cerebral blood flow in acute cerebral ischemia of man (author's transl)].
Regional cerebral blood flow (rCBF) was investigated in 18 patients with acute cerebral ischemia by the intraarterial 133Xenon clearance method using a 10-detector-equipment. Intravenous administration of 6-10 g Piracetam caused an overall increase of the fast component of rCBF after 30 minutes corresponding to blood flow in the grey matter, of 10.0 ml/100 g/min (18.9%). The slow component of rCBF corresponding to the cerebral blood flow in the white matter remained unchanged. The regional CBF was influenced to a varying degree, the areas marked by an insufficient blood supply showing a mean increase by 17.5% and the areas marked by normal basic values showing a mean increase by 6.3%. This difference in alteration is statistically significant (p is less than 0.005) comparing the differences as %. The increase of cerebral blood flow in grey matter is interpreted as a secondary effect after activation of central nervous system metabolism by Piracetam.
D002560:Cerebrovascular Circulation / Q000187:drug effects*; D006801:Humans; D010889:Piracetam / Q000494:pharmacology*; D011760:Pyrrolidinones / Q000494:pharmacology*; D011865:Radioisotope Dilution Technique; D013997:Time Factors; D014980:Xenon Radioisotopes
D011760:Pyrrolidinones; D014980:Xenon Radioisotopes; D010889:Piracetam
Die Wirkung von Piracetam auf die Gehirndurchblutung des Menschen. Quantitative regionale Hirndurchblutungsmessungen bei der akuten zerebralen Ischämie.