title: Synergy between sulphonamide and trimethoprim in the presence of pus.
abstract: Synergy between sulphadiazine and trimethoprim against Escherichia coli has been demonstrated in culture media not containing lysed horse blood despite the presence of pus or a pus extract which inhibited the action of each drug separately. Synergy may therefore be important where pus is present in vivo.
mesh_terms: D003470:Culture Media; D004357:Drug Synergism; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D013411:Sulfadiazine / Q000494:pharmacology*; D013492:Suppuration; D014295:Trimethoprim / Q000494:pharmacology*
chemical_list: D003470:Culture Media; D013411:Sulfadiazine; D014295:Trimethoprim