title: Combination chemotherapy followed by skin grafts in the management of locally advanced breast cancer.
abstract: A combined modality approach to the treatment of locally advanced, ulcerating carcinoma of the breast is discussed. The beneficial effects of combination chemotherapy have been amplified by split thickness skin grafts at the site of a large skin deficit, resulting in successful wound palliation. Criteria for assessing likelihood of graft acceptance by an ulcerating wound in the presence of local neoplastic disease are emphasized.
mesh_terms: D001940:Breast / Q000601:surgery; D001943:Breast Neoplasms / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D006801:Humans; D016038:Skin Transplantation; D014182:Transplantation, Autologous