Potential of the amino acid homology studies: homologies found between beta-galactosidase and lac repressor of E. coli.
Significant amino acid homologies were found between beta-galactosidase fragments and lac repressor of E. coli using a sliding match according to Greller and Erhan (1974). Since both of these proteins can recognise and bind galactose moiety, we propose that the homologous regions represetn galactose binding site(s) on both proteins. Possible application of homology studies to problems of protein and nucleic acid chemistry is also discussed.
D000595:Amino Acid Sequence; D001665:Binding Sites; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism*; D005690:Galactose / Q000378:metabolism; D005696:Galactosidases / Q000378:metabolism*; D007785:Lactose / Q000378:metabolism*; D008722:Methods; D013489:Suppression, Genetic; D014357:Trypsin
D005696:Galactosidases; D014357:Trypsin; D007785:Lactose; D005690:Galactose