Modification, by aspirin and indomethacin, of the haemodynamic and prostaglandin releasing effects of E. coli endotoxin in the dog.
1 Dogs treated with aspirin (10 mg/kg) or indomethacin (1.5 mg/kg) 45 min before, and 3 h after, an LD50 dose (1 mg/kg) of E. coli endotoxin were alive 72 h later. 2 Although all dogs in both treated groups survived, only those treated with indomethacin were protected against the fall in blood pressure 1-2 min following endotoxin. 3 Endotoxin increased the level of prostaglandin F2alpha in both the mixed venous and arterial blood. No increase was observed in the aspirin and indomethacin-treated groups. 4 Aspirin and indomethacin treatment did not modify thrombocytopaenia or blood coagulation parameters following endotoxin.
D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D001772:Blood Cell Count; D001792:Blood Platelets; D004285:Dogs; D004347:Drug Interactions; D004731:Endotoxins / Q000494:pharmacology*; D004926:Escherichia coli; D006439:Hemodynamics / Q000187:drug effects*; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D011460:Prostaglandins F / Q000097:blood*; D013997:Time Factors
D004731:Endotoxins; D011460:Prostaglandins F; D001241:Aspirin; D007213:Indomethacin