Leukocyte alkaline phosphatase.
In summary, LAP is an intriguing enzyme and its control is related to pituitary-adrenal function. A review of the changes in LAP activity which occur in some physiological conditions and in disease states has been presented. The function of LAP, however, is unknown. Table I summarizes those conditions in which the LAP is consistently altered enough so to help in the diagnosis of the disorder. Of prime importance is the differentiation of CML from a leukemoid reaction or agnogenic myeloid metaplasia with a leukocytosis. However, in no instance is the LAP value alone diagnostic of any disease. It remains a laboratory test to be utilized in conjunction with all other available clinical data.
D000469:Alkaline Phosphatase / Q000172:deficiency / Q000378:metabolism*; D002454:Cell Differentiation; D003276:Contraceptives, Oral / Q000378:metabolism; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007962:Leukocytes / Q000201:enzymology*; D008598:Menstruation; D008722:Methods; D009196:Myeloproliferative Disorders / Q000378:metabolism; D009504:Neutrophils / Q000166:cytology; D011247:Pregnancy
D003276:Contraceptives, Oral; D000469:Alkaline Phosphatase