Inhibition of macrophage phagocytic activity by group A streptococcal cell walls.
Group A streptococcal cell walls inhibited phagocytosis of polystyrene latex particles by rat peritoneal macrophages in vitro. This inhibition was not accompanied by a measurable loss of cell viability. Group D streptococcal cell walls were relatively ineffective in altering phagocytosis. The effectiveness of group A variant streptococcal cell walls and peptidoglycan derived from group A cell walls was increased if cell wall preparations were added to macrophage cultures 12 h before, rather than simultaneously with, latex particles.
D000818:Animals; D002470:Cell Survival; D002473:Cell Wall / Q000276:immunology*; D007840:Latex; D008264:Macrophages / Q000276:immunology*; D008863:Microspheres; D010457:Peptidoglycan / Q000494:pharmacology*; D010587:Phagocytosis; D051381:Rats; D013297:Streptococcus pyogenes / Q000276:immunology*; D013997:Time Factors
D007840:Latex; D010457:Peptidoglycan