Xipamide in the management of renal, hepatic and cardiac oedema.
Xipamide (4-chloro-5-sulphamyl-salicylic acid 2', 6'-dimethylanilide) is a diuretic and antihypertensive agent. A clinical trial of the drug was performed in 11 patients, 8 with nephrotic syndrome, 1 with oedema and ascites due to hepatic cirrhosis, and 2 with congestive cardiac failure due to idiopathic cardiomyopathy. The drug proved to be potent, safe and efficacious. Side-effects were similar to those encountered with other thiazide-derived diuretics, but were not of a severe nature. Wider clinical usage of xipamide would appear to be warranted.
D000293:Adolescent; D000328:Adult; D002986:Clinical Trials as Topic; D004232:Diuretics / Q000008:administration & dosage*; D004487:Edema / Q000188:drug therapy*; D004489:Edema, Cardiac / Q000188:drug therapy*; D005260:Female; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D008103:Liver Cirrhosis / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000188:drug therapy; D014988:Xipamide / Q000008:administration & dosage*
D004232:Diuretics; D014988:Xipamide