title: [Antithrombotic prophylaxis after surgical interventions on the major veins].
abstract: Eight-year experience in conducting antithrombotic prophylaxis, by methods elaborated by the authors, in 93 patients operated on for acute thrombosis in the system of venae cavae superior and inferior is generalized. On the basis of the results, the authors advanced the main principle of antithrombotic prophylaxis, the necessity for simultaneous correction of disorders of blood coagulation, fibrinolysis, and aggregation of formed elements of the blood. They showed that the efficacy of postoperative antithrombotic prophylaxis depends on the presence and character of hemodynamic disorders in the involved extremity. It is established that general fractional heparinization is not suitable for antithrombotic prophylaxis due to low efficacy and high rate of hemorrhagic complications. Continuous regional infusion of rheopolyglucin-heparin mixture with nicotinic acid and Trental ensures in most cases correction of the thrombotic condition of hemostasis and effective prevention of rethrombosis of the major veins with minimum hazard of hemorrhagic complications.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D003911:Dextrans / Q000008:administration & dosage; D004338:Drug Combinations; D004341:Drug Evaluation; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006487:Hemostasis / Q000187:drug effects; D006493:Heparin / Q000008:administration & dosage; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D009539:Nicotinic Acids / Q000008:administration & dosage; D010431:Pentoxifylline / Q000008:administration & dosage; D011182:Postoperative Care / Q000379:methods*; D013927:Thrombosis / Q000517:prevention & control / Q000601:surgery*; D014682:Vena Cava, Inferior / Q000601:surgery*; D014683:Vena Cava, Superior / Q000601:surgery*
chemical_list: D003911:Dextrans; D004338:Drug Combinations; D005343:Fibrinolytic Agents; D009539:Nicotinic Acids; D006493:Heparin; D010431:Pentoxifylline
vernacular_title: Antitromboticheskaia profilaktika posle operativnykh vmeshatel'stv na magistral'nykh venakh.