Cultivation of malarial parasites.
The method for continuous cultivation of Plasmodium falciparum has now been successfully applied to several strains from different geographical areas. It has been used for tests of antimalarial drugs, for studies of parasite-host cell interactions with special reference to sickle haemoglobin, and for the production of amounts of parasite sufficient for experimental immunisation of Aotus trivirgatus monkeys.
D000017:ABO Blood-Group System; D000755:Anemia, Sickle Cell / Q000469:parasitology; D000818:Animals; D000962:Antimalarials / Q000302:isolation & purification; D002478:Cells, Cultured; D004353:Drug Evaluation, Preclinical; D004912:Erythrocytes / Q000469:parasitology*; D004913:Erythrocytes, Abnormal / Q000469:parasitology; D006451:Hemoglobin, Sickle; D006801:Humans; D010963:Plasmodium falciparum / Q000254:growth & development* / Q000502:physiology; D012098:Reproduction; D012805:Sickle Cell Trait / Q000469:parasitology
D000017:ABO Blood-Group System; D000962:Antimalarials; D006451:Hemoglobin, Sickle