title: Localized chronic pemphigoid. Report of a case, review of the literature and discussion of the relationship with cicatricial pemphigoid.
abstract: A case of a chronic remittant blistering eruption on the left temple in a 62-year-old woman is described. Only after repeated biopsies did direct immunofluorescence (DIF) studies reveal a linear staining of the epidermal basement membrane with anti-IgG, C1q, C4, C3 and C5. In addition, heavy deposits of fibrin were observed. The importance of repeated DIF examination in initially negative cases has been stressed. Localized chronic pemphigoid should be considered as a distinct subform of the pemphigoid syndrome.
mesh_terms: D000418:Albumins / Q000032:analysis; D002908:Chronic Disease; D003165:Complement System Proteins / Q000032:analysis; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D005455:Fluorescent Antibody Technique; D006801:Humans; D007106:Immune Sera; D007136:Immunoglobulins / Q000032:analysis; D008875:Middle Aged; D012872:Skin Diseases, Vesiculobullous / Q000175:diagnosis / Q000276:immunology / Q000473:pathology; D012882:Skin Tests
chemical_list: D000418:Albumins; D007106:Immune Sera; D007136:Immunoglobulins; D005340:Fibrinogen; D003165:Complement System Proteins