Rapid germination of Aspergillus fumigatus conidia in mouse kidneys and a kidney extract.
Intravenously injected conidia of Aspergillus fumigatus germinated rapidly in the kidneys of untreated and cortisone-treated specific-pathogen-free (SPF) mice and in the livers of cortisone-treated SPF mice. Extracts of kidneys from untreated and cortisone-treated mice stimulated germination of A. fumigatus conidia in vitro. The possible roles of a germination stimulant and host defences in the kidney localisation of A. fumigatus infection are discussed.
D000818:Animals; D001228:Aspergillosis / Q000276:immunology / Q000382:microbiology; D001232:Aspergillus fumigatus / Q000254:growth & development*; D003348:Cortisone / Q000494:pharmacology; D007668:Kidney / Q000276:immunology / Q000382:microbiology; D007674:Kidney Diseases / Q000276:immunology / Q000382:microbiology; D008099:Liver / Q000382:microbiology; D051379:Mice; D014020:Tissue Extracts
D014020:Tissue Extracts; D003348:Cortisone