Correlation of animal brain tumor models with human neuro-oncology.
The paper reviews the histopathology and cytopathology of a number of experimental animal brain tumor models to determine their relevance to human neuro-oncology. The models discussed include brain tumors produced by local implants of carcinogenic hydrocarbons and by the administration of resorptive N-nitroso compounds, some of the cell lines derived from the latter, tumors resulting from the intracerebral inoculation of oncogenic viruses, and the differentiating neuroepithelial component of a transplantable mouse teratoma. The structural and biochemical criteria that can be applied for the identification of the various stages of neuronal and glial cell maturation are highly precise. They reveal a wide diversity of tumor cell types that are now available in experimental neuro-oncogenesis.
D000818:Animals; D001932:Brain Neoplasms / Q000209:etiology / Q000473:pathology*; D002454:Cell Differentiation; D002460:Cell Line; D004195:Disease Models, Animal; D005910:Glioma / Q000139:chemically induced / Q000473:pathology; D006801:Humans; D008748:Methylcholanthrene; D009374:Neoplasms, Experimental / Q000473:pathology; D009447:Neuroblastoma / Q000473:pathology; D009603:Nitroso Compounds; D009858:Oncogenic Viruses; D013724:Teratoma / Q000473:pathology; D014412:Tumor Virus Infections / Q000473:pathology
D009603:Nitroso Compounds; D008748:Methylcholanthrene