Oral cytembena absorption and phase I--II studies.
Cytembena is a nonmyelosuppressive drug that has received phase I--II trials in this country and is presently being used as a chemotherapeutic agent in Europe. Sterile abscesses at the site of im injection and "autonomic storm" after iv bolus represent the most frequent dose-limiting toxic effects, and intermittent schedules reflect reports of prolonged plasma levels of drug. This report of excellent oral absorption and a short half-life suggests that alternative routes and schedules of administration should be evaluated. The dose-limiting toxic effects observed after frequent oral administration were transient proteinuria and increased creatinine levels.
D000179:Acrylates / Q000009:adverse effects / Q000378:metabolism* / Q000627:therapeutic use; D000284:Administration, Oral; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D005260:Female; D006207:Half-Life; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D009369:Neoplasms / Q000188:drug therapy
D000179:Acrylates