Tubular basement membrane deposits in human renal allografts.
In 18 patients who received renal allografts, tubulo-interstitial lesions were studied, according to the types of rejection or the possible recurrence of primary disease. Immunofluorescent (IF) investigation revealed tubular basement membrane (TBM) deposits of IgG and/or C3 and sometimes other components of Complement. The pattern of these deposits was: "linear" in 3 cases, "granular" in 9 cases and "atypical" with linear and granular segments in 6 cases. The IF study of own kidneys of 3 patients, before the transplantation, revealed no TBM deposits. TBM deposits were accompanied by arterial wall deposits of IgM and/or C3 and sometimes C5 in 17 cases. Electron-microscopy study of renal tubules showed thickening, lamellation and/or deposits along the tubular basement membrane. The immunopathogenesis of these deposits was discussed.
D000888:Antibodies, Anti-Idiotypic / Q000032:analysis; D001158:Arteries / Q000276:immunology; D001485:Basement Membrane / Q000276:immunology*; D003176:Complement C3 / Q000032:analysis; D006084:Graft Rejection; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D016030:Kidney Transplantation; D007684:Kidney Tubules / Q000276:immunology / Q000648:ultrastructure*; D012008:Recurrence; D014181:Transplantation Immunology; D014184:Transplantation, Homologous
D000888:Antibodies, Anti-Idiotypic; D003176:Complement C3; D007075:Immunoglobulin M