title: The identification of the component in the inner membrane of brown adipose tissue mitochondria responsible for regulating energy dissipation.
abstract: The proton conductance of the inner membrane of hamster brown adipose tissue mitochondria can be regulated in vitro by exogenous purine nucleotides, which bind to a component on the outer face of the inner membrane. This unique mechanism has been proposed to represent the molecular site of non-shivering thermogenesis in this tissue. Using a photo-affinity analogue of ATP, we have identified the nucleotide binding component as a protein of 32,000 daltons.
mesh_terms: D002001:Adipose Tissue, Brown / Q000378:metabolism* / Q000648:ultrastructure; D000818:Animals; D004553:Electric Conductivity; D004594:Electrophysiology; D004734:Energy Metabolism; D008565:Membrane Proteins / Q000378:metabolism / Q000502:physiology*; D008928:Mitochondria / Q000378:metabolism* / Q000648:ultrastructure; D011485:Protein Binding; D011522:Protons; D011685:Purine Nucleotides / Q000378:metabolism
chemical_list: D008565:Membrane Proteins; D011522:Protons; D011685:Purine Nucleotides