title: [Clinical and immunological studies with OK-432 (Streptococcus pyogenes) on immunotherapy in cancer patients].
abstract: In a phase I study, the bacterial vaccine OK-432 (streptococcus pyogenes) was investigated in eight patients with advanced malignant tumors. Besides a fever reaction after i.v. application no toxic side effects were observed. Additionally, its therapeutic effectiveness could be demonstrated by i.v. and local therapy. There was also observed an increase of lymphocyte blastogenesis response in patients under treatment with OK-432.
mesh_terms: D001428:Bacterial Vaccines / Q000627:therapeutic use*; D008213:Lymphocyte Activation; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000628:therapy*; D013297:Streptococcus pyogenes / Q000276:immunology*
chemical_list: D001428:Bacterial Vaccines
vernacular_title: Klinische und immunologische Untersuchungen mit OK-432 (Streptococcus pyogenes) zur Immuntherapie bei Krebspatienten.