Limiting factors in bacterial phagocytosis by human polymorphonuclear leukocytes.
Limiting factors in neutrophil phagocytosis were studied using a sensitive assay by which attachment, ingestion and intracellular killing of bacteria could be separated. Phagocytosis was found to be limited by the attachment capacity of neutrophils. Ingestion and intracellular killing proceeded at a constant rate proportional to the number of bacteria attached to the neutrophils.
D001419:Bacteria; D004926:Escherichia coli; D006801:Humans; D009504:Neutrophils / Q000276:immunology*; D010587:Phagocytosis; D011110:Polymorphism, Genetic; D013210:Staphylococcus; D013211:Staphylococcus aureus; D013291:Streptococcus