[Influence of haloperidol on the 3H-leucine incorporation in incretory organs of the mouse (author's transl)].
The 3H-leucine incorporation in proteins of incretory organs of the mouse, the exocrine pancreas, and the renal tubuli was studied autoradiographically after administration of therapylike doses of the neuroleptic drug Haloperidol. With exception of the pancreas, a dosage of dependent increase of the 3H-leucine incorporation was observed in the treated animals. In our opinion, the results reveal an activation of the hypothalamus-hypophysis-adrenocortical system due to a 10-days administration of Haloperidol. These results are in conformity with former ones in brain and liver.
D000311:Adrenal Glands / Q000187:drug effects; D000818:Animals; D004702:Endocrine Glands / Q000187:drug effects*; D005260:Female; D006220:Haloperidol / Q000494:pharmacology*; D007515:Islets of Langerhans / Q000187:drug effects; D007684:Kidney Tubules / Q000187:drug effects* / Q000378:metabolism; D007930:Leucine / Q000378:metabolism; D051379:Mice; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D010902:Pituitary Gland / Q000187:drug effects; D011506:Proteins / Q000378:metabolism*; D013495:Supraoptic Nucleus / Q000187:drug effects; D013961:Thyroid Gland / Q000187:drug effects; D014316:Tritium
D011506:Proteins; D014316:Tritium; D007930:Leucine; D006220:Haloperidol
Inkorporation von 3-H-Leuzin in Proteine des inkretorischen Systems der Maus under dem Einfluss von Haloperidol.