Protection against syngeneic tumor grafts induced by inoculation with normal allogeneic tissues.
Subcutaneous injection of normal allogeneic kidney and liver tissues extended survival of DBA/2Cr mice challenged with a lethal dose of syngeneic L5178Y lymphoma cells. Immunization with a combination of tissues from five strains provided far more protection than immunization with tissue from any single strain. It is suggested that the basis of this protective effect is a cross-reactivity or identity between tumor-associated transplantation antigens (TATA) on the L5178Y tumor and non-H-2 alloantigens normally expressed by some allogeneic tissues.
D000818:Animals; D003429:Cross Reactions; D005260:Female; D006649:Histocompatibility Antigens; D007114:Immunization; D016030:Kidney Transplantation; D007939:Leukemia L1210 / Q000276:immunology; D016031:Liver Transplantation; D051379:Mice; D008805:Mice, Inbred A; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009368:Neoplasm Transplantation; D014184:Transplantation, Homologous; D014185:Transplantation, Isogeneic; D014965:X-Rays
D006649:Histocompatibility Antigens