Effect of an acute dose of ethanol on rat liver microsomal mixed function oxygenase components and membrane lipid composition.
The lipid composition of rat liver microsomes was not altered in response to a single acute dose of ethanol relative to isocaloric glycerol-treated controls. Microsomal cytochrome P-450 was transiently elevated, the elevation paralleling blood ethanol levels. Microsomal NADPH oxidase was transiently elevated relative to the activity in isocaloric glycerol-treated controls.
D000818:Animals; D000431:Ethanol / Q000097:blood / Q000494:pharmacology*; D005227:Fatty Acids / Q000378:metabolism; D008099:Liver / Q000187:drug effects; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism*; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D009929:Organ Size / Q000187:drug effects; D010088:Oxidoreductases / Q000378:metabolism*; D051381:Rats; D013997:Time Factors
D005227:Fatty Acids; D008563:Membrane Lipids; D000431:Ethanol; D006899:Mixed Function Oxygenases; D010088:Oxidoreductases