title: [On the problem of praetherapeutic sensitivity testing of human tumours based on incorporation studies of nucleic acid precursors in vitro (author's transl)].
abstract: Praetherapeutic sensitivity tests of human solid tumours based on incorporation studies of nucleic acid precursors have been described by various authors. This review intends to show that such tests may only be of rather limited value for the design of individual chemotherapeutic regimens. In many drugs, a correlation between biochemical and clinical effects has not yet been established. The reliability of praetherapeutic sensitivity tests is further impaired by general methodological difficulties of short-term cultures, individual pharmacology and toxicology of cytostatic agents as well as pharmacological and biochemical drug interactions in combination chemotherapy. Praetherapeutic testing with individual cytostatic drugs is discussed.
mesh_terms: D000477:Alkylating Agents / Q000494:pharmacology; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D000964:Antimetabolites, Antineoplastic / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D004273:DNA, Neoplasm / Q000096:biosynthesis*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D006801:Humans; D066298:In Vitro Techniques; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D009694:Nucleic Acid Precursors / Q000378:metabolism*; D012334:RNA, Neoplasm / Q000096:biosynthesis*; D013936:Thymidine / Q000378:metabolism; D014529:Uridine / Q000378:metabolism
chemical_list: D000477:Alkylating Agents; D000903:Antibiotics, Antineoplastic; D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D004273:DNA, Neoplasm; D009694:Nucleic Acid Precursors; D012334:RNA, Neoplasm; D013936:Thymidine; D014529:Uridine
vernacular_title: Zum Problem der prätherapeutischen Sensibilitätsbestimmung von Tumoren durch Inkorporationsstudien in vitro.