title: Cell membrane ionic permeability, calcium ion, mitochondria, and carcinogenesis.
abstract: The interrelations between changes in cell membrane permeability, increase of intracellular concentration of calcium ion and alterations of the bioenergetic and genetic mechanisms of the mitochondria are formalized in a hypothesis of carcinogenesis. It seems very likely that changes in the permeability of the cell membrane induced by the carcinogen are responsible for increased intracellular accumulation of Ca2+. This phenomenon produces mitochondrial damage associated with permanent modifications of the structural and functional characteristics of the cell membranes as well as of the genetic mechanisms controlling cell division.
mesh_terms: D001692:Biological Transport; D002118:Calcium; D002273:Carcinogens; D002412:Cations; D002455:Cell Division; D002463:Cell Membrane Permeability; D006801:Humans; D008274:Magnesium; D008928:Mitochondria / Q000502:physiology*; D008933:Mitochondrial Swelling; D010085:Oxidative Phosphorylation
chemical_list: D002273:Carcinogens; D002412:Cations; D008274:Magnesium; D002118:Calcium