Treatment of fluid retention in cirrhosis: a comparison of bumetanide and frusemide.
Bumetanide and frusemide were compared in a crossover study of 10 patients with cirrhosis and fluid overload. Patients received each drug for 3 months. Doses of bumetide varied from 1 mg on alternate days to 3 mg daily (mean 1.3 mg/day), and for frusemide from 40 mg on alternate days to 160 mg daily (mean 72 mg/day). Both drugs proved effective in controlling ascites and oedema, 9 out of the 10 patients showing a satisfactory response. Minor side-effects, hypokalaemia and hyperuricaemia were common with both agents, and hypomagnesaemia and metabolic alkalosis developed in some patients.
D000328:Adult; D000368:Aged; D001201:Ascites / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D002034:Bumetanide / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004232:Diuretics / Q000627:therapeutic use*; D004487:Edema / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D005665:Furosemide / Q000627:therapeutic use*; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000150:complications*; D008297:Male; D008875:Middle Aged
D004232:Diuretics; D002034:Bumetanide; D005665:Furosemide