title: Cluster of genes controlling proline degradation in Salmonella typhimurium.
abstract: A cluster of genes essential for degradation of proline to glutamate (put) is located between the pyrC and pyrD loci at min 22 of the Salmonella chromosome. A series of 25 deletion mutants of this region have been isolated and used to construct a fine-structure map of the put genes. The map includes mutations affecting the proline degradative activities, proline oxidase and pyrroline-5-carboxylic dehydrogenase. Also included are mutations affecting the major proline permease and a regulatory mutation that affects both enzyme and permease production. The two enzymatic activities appear to be encoded by a single gene (putA). The regulatory mutation maps between the putA gene and the proline permease gene (putP).
mesh_terms: D000594:Amino Acid Oxidoreductases / Q000235:genetics; D002874:Chromosome Mapping; D005796:Genes; D005809:Genes, Regulator; D009154:Mutation; D011392:Proline / Q000235:genetics / Q000378:metabolism*; D011762:Pyrroline Carboxylate Reductases / Q000235:genetics; D012486:Salmonella typhimurium / Q000235:genetics / Q000378:metabolism*
chemical_list: D011392:Proline; D000594:Amino Acid Oxidoreductases; D011762:Pyrroline Carboxylate Reductases