Effect of demycarosylturimycin on ribosomal peptidyltransferase from Escherichia coli.
The effect of demycarosylturimycin H on bacterial growth, polypeptide synthesis and peptidyltransferase was studied. The effects are compared with those of intact turimycins acylated or deacylated in 4''-position of mycarose. The removal of the acyl group in 4''-position of mycarose leads to a total loss of inhibition of acceptor substrate binding while the removal of acyl mycarose moiety changes the pattern of inhibition of polypeptide synthesis.
D000217:Acyltransferases / Q000037:antagonists & inhibitors*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004347:Drug Interactions; D004917:Erythromycin / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology* / Q000648:ultrastructure; D007933:Leucomycins / Q000494:pharmacology; D010452:Peptide Biosynthesis; D010458:Peptidyl Transferases / Q000037:antagonists & inhibitors*; D011691:Puromycin / Q000494:pharmacology; D012270:Ribosomes / Q000201:enzymology*
D000900:Anti-Bacterial Agents; D007933:Leucomycins; D011691:Puromycin; D004917:Erythromycin; D000217:Acyltransferases; D010458:Peptidyl Transferases