[Comparison of cardiac and vascular effects of sulfentanil (R 30730), a new analgetic, and fentanyl (author's transl)].
In 31 patients with congenital or acquired heart disease, functional class III NYHAC, effects of Sulfentanil (R 30730)--a new analgetic--on hemodynamics, inotropic state and myocardial oxygen consumption have been investigated intraoperatively, during extracorporeal circulation and postoperatively. Results are compared to a fentanyl-group and control-group. There was almost no change in cardiac index and stroke index. In comparison to fentanyl (dose relation fentanyl: sulfentanil = 10:1) there was a more pronounced decrease in aterial pressure, left ventricular pressure, peak dp/dt and myocardial oxygen consumption (-20%) in the sulfentanil-group. In contrast to the fentanyl-group there was, however, no increase in total pulmonary resistance with sulfentanil.
D000328:Adult; D000403:Airway Resistance / Q000187:drug effects; D006348:Cardiac Surgical Procedures; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D005112:Extracorporeal Circulation; D005260:Female; D005283:Fentanyl / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism; D009458:Neuroleptanalgesia; D010101:Oxygen Consumption / Q000187:drug effects; D011184:Postoperative Period
D005283:Fentanyl
Vergleichende Untersuchungen zu kardialen und vaskulären Effekten des neuen Analgetikums Sulfentanil (R 30730) und Fentanyl.