Radioprotective activity of interferon inducers.
The radioprotective activity of interferon inducers (tilorone, Acranil, poly I:C and LPS) was investigated against acute X-ray irradiation and prolonged 60Co-gamma rays irradiation. The endogenous spleen colony formation test and percentage of surviving mice 30 days after irradiation were used as indicators. All interferon inducers investigated proved to have radioprotective activity.
D000166:Acridines / Q000627:therapeutic use; D000585:Aminacrine / Q000031:analogs & derivatives; D000818:Animals; D000981:Antiprotozoal Agents / Q000627:therapeutic use; D004926:Escherichia coli; D005260:Female; D005449:Fluorenes / Q000627:therapeutic use*; D007369:Interferon Inducers / Q000627:therapeutic use*; D008070:Lipopolysaccharides / Q000627:therapeutic use; D008297:Male; D051379:Mice; D011070:Poly I-C / Q000627:therapeutic use; D011135:Polysaccharides, Bacterial / Q000627:therapeutic use; D011412:Propanolamines / Q000627:therapeutic use; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents; D013154:Spleen / Q000276:immunology; D013994:Tilorone / Q000627:therapeutic use*
D000166:Acridines; D000981:Antiprotozoal Agents; D005449:Fluorenes; D007369:Interferon Inducers; D008070:Lipopolysaccharides; D011135:Polysaccharides, Bacterial; D011412:Propanolamines; D011837:Radiation-Protective Agents; D000585:Aminacrine; D013994:Tilorone; D011070:Poly I-C; C006397:acranil