Cardiovascular effects of positive end-expiratory pressure in dogs.
Our purpose was to reexamine the relationship of the fall in cardiac output and blood pressure which occurs during positive end-expiratory pressure (PEEP) to changes in transmural right atrial and left atrial filling pressures. Closed-chest dogs, half with pulmonary edema, were studied during spontaneous breathing and inspiratory positive-pressure breathing (IPPB) with 0-15 cmH2O PEEP. Mean esophageal pressure accurately reflected changes in pericardial pressure and was used to estimate extracardiac pressure. We found that cardiac output fell approximately 50% and blood pressure fell 20% during 15 cmH2OPEEP in spite of well maintained transmural right atrial and left atrial (or pulmonary artery wedge) pressures suggesting a primary or reflex depression of atrial or ventricular function.
D000758:Anesthesia; D000818:Animals; D016275:Atrial Function; D001794:Blood Pressure; D002302:Cardiac Output; D002320:Cardiovascular Physiological Phenomena; D004285:Dogs; D004947:Esophagus / Q000098:blood supply; D006339:Heart Rate; D007384:Intermittent Positive-Pressure Breathing; D008954:Models, Biological; D010496:Pericardium / Q000502:physiology; D011175:Positive-Pressure Respiration / Q000009:adverse effects*; D011651:Pulmonary Artery; D011654:Pulmonary Edema / Q000503:physiopathology / Q000628:therapy