title: Evaluation of an experimental anticholinergic drug, elantrine, in treating the tremor of parkinsonism.
abstract: An experimental anticholinergic drug, elantrine, had shown significant improvement in tremor of parkinsonism in 89 patients not taking L-dopa. A double-blind study of 22 parkinsonian patients stabilized on L-dopa showed marked improvement in tremor and moderate improvement in rigidity and bradykinesia when elantrine was added to their treatment program. Nine of 15 patients taking L-dopa (or Sinemet) and elantrine had cessation of all tremor and have continued free of tremor to date, over two years.
mesh_terms: D002986:Clinical Trials as Topic; D003984:Dibenzazepines / Q000627:therapeutic use*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D010276:Parasympatholytics / Q000627:therapeutic use*; D010300:Parkinson Disease / Q000188:drug therapy*; D010919:Placebos
chemical_list: D003984:Dibenzazepines; D010276:Parasympatholytics; D010919:Placebos; D007980:Levodopa