Double-blind study of ketoprofen and indomethacin in juvenile chronic arthritis.
Ketoprofen (Orudis; Maybaker), whose use has not previously been reported in choldren, was compared with indomethacin in a double-blind crossover trial in 30 children with juvenile chronic arthritis. Both drugs proved to be safe and effective analgesics and anti-inflammatory agents although indomethacin emerged as the preferred drug. Perhaps higher doses of ketoprofen would be safe and more effective. Side-effects were few and mild. The problems of patient compliance and the assessment of pain in children are discussed.
D000293:Adolescent; D001171:Arthritis, Juvenile / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use*; D007660:Ketoprofen / Q000627:therapeutic use*; D010666:Phenylpropionates / Q000627:therapeutic use*
D010666:Phenylpropionates; D007660:Ketoprofen; D007213:Indomethacin