Skin flap necrosis in guinea pigs: limitation of glucose supply and accumulation of lactate.
The distribution of glucose and lactate within skin flaps was determined in full-thickness guinea pig skin (excluding the panniculus carnosus). The distal end of the flaps had a low glucose content (less than 50 percent of normal) but high lactate level (2 to 3 times normal) during the 3 days after flap elevation. Progressively decreasing gradients of glucose content, and increasing gradients of lactate content, were demonstrated from the mid-region to the distal end of the flaps at 3 hours postoperatively. The decrease in glucose and the accumulation of lactate may play a significant role in skin necrosis.
D000818:Animals; D005947:Glucose / Q000378:metabolism*; D006168:Guinea Pigs; D007773:Lactates / Q000378:metabolism*; D008297:Male; D009336:Necrosis; D012039:Regional Blood Flow; D012867:Skin / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology; D016038:Skin Transplantation; D014182:Transplantation, Autologous
D007773:Lactates; D005947:Glucose