title: A 3-months' study of enzymes as denture cleansers.
abstract: It was the purpose of the study to test the efficacy of dissolvent tablets containing mutanase and protease in removing denture plaque. The study group consisted of forty institutionalized geriatric denture wearers, who were assigned randomly into an enzyme group and a placebo group. Enzyme tablets and placebo for denture soaking were administered by the nurses. The dentures were immersed for 15 min once daily for three months. The amount of denture plaque, the clinical condition of the palatal mucosa, and the concentration of yeasts and bacteria in mucosal and denture smears were recorded before, during, and after the experimental period. The study was designed and carried out as a double-blind study. After denture soaking for six weeks a significant reduction of the amount of denture plaque and improvement of the clinical condition of the palatal mucosa was recorded. After denture soaking for twelve weeks the conditions had improved further when comparing the enzyme group with the placebo group.
mesh_terms: D001419:Bacteria / Q000166:cytology; D002986:Clinical Trials as Topic; D003773:Dental Plaque / Q000517:prevention & control*; D003824:Denture, Complete; D004311:Double-Blind Method; D006026:Glycoside Hydrolases / Q000627:therapeutic use*; D006801:Humans; D007101:Immersion; D010159:Palate / Q000382:microbiology; D010447:Peptide Hydrolases / Q000627:therapeutic use*; D010919:Placebos; D013499:Surface Properties; D013607:Tablets
chemical_list: D010919:Placebos; D013607:Tablets; D006026:Glycoside Hydrolases; C021780:exo-1,3-alpha-glucanase; D010447:Peptide Hydrolases