Regional differences in prostacyclin formation by the kidney. Prostacyclin is a major prostaglandin of renal cortex.
Microsomes prepared from rabbit renal cortex were found to synthesize substantial amounts of 6-ketoprostaglandin F1alpha from prostaglandin G2 or arachidonic acid during an incubation. In contrast, no 6-ketoprostaglandin F1alpha was formed by renal medullary microsomes which synthesize predominantly prostaglandin E2. Mass spectral confirmation of the structure of 6-ketoprostaglandin F1alpha from these incubations demonstrates the ability of the renal cortex to synthesize prostacyclin.
D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism; D011464:Epoprostenol / Q000096:biosynthesis*; D007651:Keto Acids / Q000378:metabolism; D007672:Kidney Cortex / Q000378:metabolism* / Q000648:ultrastructure; D007679:Kidney Medulla / Q000378:metabolism; D008861:Microsomes / Q000378:metabolism; D011453:Prostaglandins / Q000096:biosynthesis*; D011460:Prostaglandins F / Q000378:metabolism; D011462:Prostaglandins G / Q000378:metabolism; D011817:Rabbits; D012083:Renin / Q000378:metabolism
D001095:Arachidonic Acids; D007651:Keto Acids; D011453:Prostaglandins; D011460:Prostaglandins F; D011462:Prostaglandins G; D011464:Epoprostenol; D012083:Renin