title: Immunopathogenesis of chronic periapical lesions. A review.
abstract: The pathogenesis of periapical lesions has not been fully elucidated. Currently, the possibility of its being an immunologic phenomenon is receiving much attention. This article presents a review of the literature concerning immunologic reactions which may involve periapical lesions. It appears that antigen-antibody complexes and IgE-mediated reactions can initiate preliminary changes in periapical tissues. It is also likely that delayed hypersensitivity participates in the perpetuation and progression of periapical disease.
mesh_terms: D000906:Antibodies / Q000032:analysis; D000936:Antigen-Antibody Complex; D000941:Antigens / Q000276:immunology; D001862:Bone Resorption / Q000276:immunology*; D002908:Chronic Disease; D003165:Complement System Proteins / Q000276:immunology; D003788:Dental Pulp Diseases / Q000276:immunology; D004731:Endotoxins / Q000276:immunology; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007073:Immunoglobulin E / Q000502:physiology; D007074:Immunoglobulin G / Q000502:physiology; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology; D008263:Macrophage Migration-Inhibitory Factors / Q000502:physiology; D008264:Macrophages / Q000276:immunology; D009504:Neutrophils / Q000276:immunology; D010486:Periapical Tissue / Q000276:immunology*; D010510:Periodontal Diseases / Q000276:immunology; D010950:Plasma Cells / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000906:Antibodies; D000936:Antigen-Antibody Complex; D000941:Antigens; D004731:Endotoxins; D007074:Immunoglobulin G; D008263:Macrophage Migration-Inhibitory Factors; D007073:Immunoglobulin E; D003165:Complement System Proteins