title: Comparison between the oxygen removal rate and the histological structure of normal and tumour tissues.
abstract: A technique has been used to measure distributions of oxygen removal rate, QR, in samples of recently excised tissue where QR is defined as the ratio of the oxygen uptake rate to the oxygen solubility. QR was measured at 91 sampling points across a cross section of tissue of diameter 5 mm. By placing markers in the tissue and using special procedures to obtain sections of the tissue samples it was possible to compare the distributions of QR with the histological structure of the tissues. The overall resolution of the system is about 1/2 mm so that structures of the order of a millimetre or more could be examined. There are considerable inhomogeneities in QR within some normal tissues, for example 4-19 mm Hg/s in rat kidney and 0.4-1.5 mm Hg/s in human cervix. Inhomogeneities in tumour tissues are also associated with the histological structure and examples for the Lewis lung mouse carcinoma show a correlation between QR and regions of viable or necrotic tissue. For a biopsy sample of human carcinoma of the cervix QR correlates with the degree of local infiltration by tumour cells.
mesh_terms: D000818:Animals; D002277:Carcinoma / Q000378:metabolism*; D002584:Cervix Uteri / Q000378:metabolism*; D005260:Female; D006652:Histological Techniques; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D008175:Lung Neoplasms / Q000378:metabolism; D009374:Neoplasms, Experimental / Q000378:metabolism; D010101:Oxygen Consumption; D051381:Rats; D002583:Uterine Cervical Neoplasms / Q000378:metabolism*