title: Baclofen in the treatment of schizophrenia: a pilot study.
abstract: 10 chronic schizophrenics were treated with baclofen for 30 days in addition to the neuroleptic maintenance medication. The psychopathological findings were documented in intervals of 5 days using a global rating and the BPRS scale. 3 patients showed a definite slight improvement of their clinical condition, 2 patients showed a questionable improvement, whereas 5 patients did not change. The statistical analysis of the BPRS scale revealed a significant improvement of one higher order factor. Our pilot study suggests that baclofen may have positive effects on some schizophrenics.
mesh_terms: D000328:Adult; D000613:Aminobutyrates / Q000627:therapeutic use*; D001418:Baclofen / Q000627:therapeutic use*; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008875:Middle Aged; D010865:Pilot Projects; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000188:drug therapy*; D013997:Time Factors
chemical_list: D000613:Aminobutyrates; D001418:Baclofen