[Effect of monoamine levels on gonadotropin releasing hormone concentration in the hypothalamus, pituitary gonadotropic fuction and ovarian ovulatory and hormonal function].
Daily administration of 0.25 mg reserpine during 14 days reduces the noradrenaline and dopamine level in the hypothalamus by 21--47 per cent and the LH level in the blood. The amount of Gn-RH in the supra-and retrochiasmatic portions of the hypothalamus is significantly increased thereby indicating an inhibition of the RH release into the blood of portal vein. The same course of 0.5--0.75 mg reserpine reduces the level of catecholamines by 51--82 per cent, the Gn-Rh content decreasing in the preoptic, supra-and retrochiasmatic areas along with further decrease of LH level in the blood. This is due, probably, to disturbance of both synthesis and release of Gn-RH. Consequently, the catecholamines activate primarily the release and then the synthesis of Gn-RH. The level of gonadotropins in hypophysis undergoes no essential alterations under the influence of reserpine, the animals develop a constant diestrus, great major yellow bodies appearing in the ovaires while the number of folliculi reduces. The hormonal activity of ovaries at that (secretion of estrogens and progesterone) decreases.
D000818:Animals; D001679:Biogenic Amines / Q000502:physiology*; D004298:Dopamine / Q000502:physiology; D004967:Estrogens / Q000097:blood; D004971:Estrus; D005260:Female; D005640:Follicle Stimulating Hormone / Q000032:analysis; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism*; D007031:Hypothalamus / Q000032:analysis; D007986:Luteinizing Hormone / Q000032:analysis; D009638:Norepinephrine / Q000502:physiology; D009929:Organ Size; D010053:Ovary / Q000502:physiology*; D010060:Ovulation / Q000187:drug effects; D010903:Pituitary Gland, Anterior / Q000032:analysis; D010906:Pituitary Hormone-Releasing Hormones / Q000032:analysis; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D051381:Rats; D012110:Reserpine / Q000494:pharmacology; D012701:Serotonin / Q000502:physiology; D014599:Uterus / Q000502:physiology
D001679:Biogenic Amines; D004967:Estrogens; D010906:Pituitary Hormone-Releasing Hormones; D012701:Serotonin; D011374:Progesterone; D012110:Reserpine; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D004298:Dopamine; D009638:Norepinephrine
Vliianie urovnia monoaminov na soderzhanie gonadotropin-rilizing gormona v gipotalamuse, gonadotropunuiu funktsiiu gipofiza, ovuliatornuiu i gormonal'nuiu funktsiiu iaichnikov.