Viremia in experimental Creutzfeldt-Jakob disease.
Inoculation of the buffy coat of blood from guinea pigs infected with Creutzfeldt-Jakob disease resulted in passage of this disease to recipient animals. This demonstrates that there is a viremia in experimental Creutzfeldt-Jakob disease. These findings suggest that the hematogenous route may be implicated in the human infection and that the disease may possibly be transmitted by blood transfusions.
D000818:Animals; D001769:Blood / Q000382:microbiology*; D007562:Creutzfeldt-Jakob Syndrome / Q000097:blood / Q000382:microbiology* / Q000635:transmission; D004195:Disease Models, Animal; D006168:Guinea Pigs; D006801:Humans; D007962:Leukocytes / Q000382:microbiology