title: New major outer membrane proteins found in an Escherichia coli tolF mutant resistant to bacteriophage TuIb.
abstract: Cell envelopes prepared from an Escherichia coli tolF strain selected as resistant to phage TuIb contained a new major outer membrane protein related to outer membrane proteins Ia and Ib. The strain that produces this protein is a tolF par double mutant but contains an additional mutation leading to the production of the new major outer membrane protein. Antibiotic sensitivity lost as a result of the tolF mutation is regained in strains that contain the new major outer membrane protein. This indicates that this protein functions to restore the selective permeability of the outer membrane to low-molecular-weight hydrophilic molecules.
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000502:physiology*; D002463:Cell Membrane Permeability; D003087:Colicins / Q000494:pharmacology; D003090:Coliphages / Q000254:growth & development; D004926:Escherichia coli / Q000235:genetics / Q000502:physiology*; D005796:Genes; D008565:Membrane Proteins / Q000502:physiology*; D009154:Mutation
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D003087:Colicins; D008565:Membrane Proteins