alpha-Adrenolytic treatment in patients with autonomous bladders.
The effect of alpha-adrenolytic treatment (phenoxybenzamine) was studied in 8 patients with lower motor neuron lesions (autonomous bladders). In the cystometrograms, the bladders were more hypotonic and the "autononous waves" appeared at a higher level of filling or were totally extinguished after this pharmacological treatment. With an isotonic volume registration method, a bladder volume increase was recorded after alpha-adrenergic blockage. Using spincterometry or urethral pressure profile studies, a decrease in the urethral resistance was observed after alpha-adrenolytic treatment, resulting in a decrease in residual urine. This decrease in bladder wall tension and in residual urine effected an increased functional bladder capacity in patients with autonomous bladders.
D000328:Adult; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010643:Phenoxybenzamine / Q000627:therapeutic use*; D011312:Pressure; D014521:Urethra / Q000187:drug effects; D001743:Urinary Bladder / Q000187:drug effects; D001750:Urinary Bladder, Neurogenic / Q000188:drug therapy*; D014554:Urination; D014563:Urodynamics / Q000187:drug effects*
D010643:Phenoxybenzamine