Para-aminosalicylic acid as a lipid-lowering agent.
The capacity of para-aminosalicylic acid (PAS) to lower initially high serum lipoprotein lipid concentrations was tested in a double-blind crossover study. Thirty patients who were on a lipid-lowering diet were treated with PAS (6 gm daily) for 4 wk. There was an average reduction of the serum triglyceride concentration of 28% (p less than 0.001) and of 12% of the serum cholesterol concentration (p less than 0.001) corresponding to a reduction of very low density lipoprotein (VLDL) triglycerides of 40% (p less than 0.001) and low density lipoprotein (LDL) cholesterol of 6% (p less than 0.05). In hypercholesterolemic patients, the LDL cholesterol reduction was 14% (p less than 0.001). In patients with hypertriglyceridemia type IV, the mean reduction of the VLDL triglyceride concentration was 47% (p less than 0.01), corresponding to a serum triglyceride reduction by 37% (p less than 0.01). In spite of the decrease of VLDL concentration, there was an unexpected reduction of the lipoprotein lipase activity in adipose tissue of 16% (p less than 0.02). The glucose tolerance and the serum insulin concentrations at fasting and after glucose injection were not changed.
D000273:Adipose Tissue / Q000201:enzymology; D000328:Adult; D000368:Aged; D010131:Aminosalicylic Acid / Q000009:adverse effects / Q000494:pharmacology*; D000636:Aminosalicylic Acids / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005215:Fasting; D005260:Female; D005947:Glucose / Q000494:pharmacology; D005951:Glucose Tolerance Test; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood; D000960:Hypolipidemic Agents; D007328:Insulin / Q000097:blood; D008071:Lipoprotein Lipase / Q000378:metabolism; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood
D000636:Aminosalicylic Acids; D000960:Hypolipidemic Agents; D007328:Insulin; D008074:Lipoproteins; D014280:Triglycerides; D010131:Aminosalicylic Acid; D008071:Lipoprotein Lipase; D005947:Glucose