Islet function in diabetics with persistent islet cell antibodies.
Seventeen (14 per cent) of 121 long-term insulin-treated diabetics were found to be positive for islet cell antibodies. Their duration of diabetes ranged between five and 45 years. Thirteen of these 17 patients were tested for the persistence of islet cell function by measurement of C-peptide. There was no detectable C-peptide in 12 patients, confirming that islet function had ceased. The significance of the persistence of islet cell antibodies in diabetes is unknown.
D000293:Adolescent; D000328:Adult; D002648:Child; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000276:immunology* / Q000503:physiopathology; D005260:Female; D006680:HLA Antigens; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D007330:Insulin Antibodies; D007515:Islets of Langerhans / Q000276:immunology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged
D006680:HLA Antigens; D007328:Insulin; D007330:Insulin Antibodies