Synthesis of vitellogenin, an attractive model for investigating hormone-induced gene activation.
The estrogen-induced synthesis of vitellogenin in the frog Xenopus and the chicken is an attractive system for investigating the molecular events leading to the activation of a specific gene. In this review article the events occurring at the level of the protein and mRNA in the cytoplasm are discussed. The available data show that the induction of vitellogenin synthesis is due to the accumulation of the corresponding vitellogenin mRNA in the cytoplasm. This suggests that transcriptional or posttranscriptional events in the nucleus are activated by the hormone. The few experiments investigating the processes in the nuclear compartment are reviewed.
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D002645:Chickens; D003593:Cytoplasm / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D004530:Egg Yolk; D004794:Enzyme Repression / Q000187:drug effects; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D005796:Genes / Q000187:drug effects; D005815:Genetic Code; D008074:Lipoproteins / Q000096:biosynthesis*; D008099:Liver / Q000378:metabolism; D008297:Male; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000378:metabolism*; D012737:Sex Factors; D013045:Species Specificity; D014158:Transcription, Genetic / Q000187:drug effects; D014819:Vitellogenins / Q000096:biosynthesis*; D014981:Xenopus
D004967:Estrogens; D008074:Lipoproteins; D012333:RNA, Messenger; D014819:Vitellogenins; D004247:DNA