Detection of mutagenicity of the colon carcinogen 1,2-dimethylhydrazine by the host-mediated assay and its correlation to carcinogenicity.
Mutagenic potential of 1,2-dimethylhydrazine (DMH) was investigated in the host-mediated assay with mice used as hosts. This assay revealed potent mutagenicity of this colon carcinogen for Salmonella typhimurium G46. The mutagenicity of DMH was inhibited by pretreatment of mice with disulfiram. In addition, mouse strain and sex differences influenced the mutation induction by DMH: Mutation induction was significantly lower in C57BL/6 mice than in outbred ICR mice of either sex and was generally higher in male than in females of either C57BL/6 or ICR mice.
D000818:Animals; D002273:Carcinogens; D003110:Colonic Neoplasms / Q000139:chemically induced; D004127:Dimethylhydrazines / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005260:Female; D008297:Male; D008763:Methylhydrazines / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009153:Mutagens; D009374:Neoplasms, Experimental / Q000139:chemically induced; D012486:Salmonella typhimurium / Q000187:drug effects; D012737:Sex Factors; D013045:Species Specificity
D002273:Carcinogens; D004127:Dimethylhydrazines; D008763:Methylhydrazines; D009153:Mutagens