PGI2: a potential mediator of inflammation.
PGI2, but not its metabolite 6oxoPGF1alpha, is equivalent in potency to PGE1 as a potentiator of carrageenan, histamine and bradykinin-induced rat paw oedemas. PGI2 must, therefore, be considered as a potential mediator of inflammatory processes.
D000818:Animals; D001920:Bradykinin / Q000008:administration & dosage; D002351:Carrageenan / Q000008:administration & dosage; D004357:Drug Synergism; D004487:Edema / Q000139:chemically induced*; D011464:Epoprostenol / Q000008:administration & dosage*; D005260:Female; D006614:Hindlimb; D006632:Histamine / Q000008:administration & dosage; D007267:Injections; D011453:Prostaglandins / Q000008:administration & dosage*; D011458:Prostaglandins E / Q000008:administration & dosage; D051381:Rats
D011453:Prostaglandins; D011458:Prostaglandins E; D006632:Histamine; D002351:Carrageenan; D011464:Epoprostenol; D001920:Bradykinin