Specificity of arrest, survival, and growth of selected metastatic variant cell lines.
Animal tumor models for blood-borne metastasis have been developed by in vitro cloning or in vivo selection of malignant tumor cell populations to obtain organ-preferring variant tumor cell lines with altered arrest, survival, invasion, and growth properties. Selection and some tumor cell characteristics of lung-, brain-, and ovary-colonizing metastatic B16 melanoma, liver-colonizing RAW114 lymphosarcoma, and lung-colonizing MSV3T3 vasoformative sarcoma variant lines will be discussed along with additional data, suggesting that tumor cells of varying malignant potential preeexist in the unselected tumor population.
D000818:Animals; D001932:Brain Neoplasms / Q000473:pathology; D002455:Cell Division; D002460:Cell Line; D002462:Cell Membrane / Q000473:pathology; D002470:Cell Survival; D003602:Cytotoxicity, Immunologic; D004195:Disease Models, Animal; D005260:Female; D008113:Liver Neoplasms / Q000473:pathology; D008175:Lung Neoplasms / Q000473:pathology; D008214:Lymphocytes / Q000276:immunology; D008545:Melanoma / Q000276:immunology / Q000473:pathology; D051379:Mice; D009362:Neoplasm Metastasis; D009374:Neoplasms, Experimental / Q000097:blood / Q000276:immunology / Q000473:pathology*; D009360:Neoplastic Cells, Circulating; D010051:Ovarian Neoplasms / Q000473:pathology; D012513:Sarcoma, Experimental / Q000473:pathology