[Comparison between the presence of specific circulating immune complexes and the leukocyte migration inhibition test in different clinical forms of hepatitis B].
Circulating immune complexes were measured by a radioimmunoassay specific for HB complexes in different clinical situations related to hepatitis B virus infection. The leukocyte migration inhibition test (LMIT) was performed simultaneously. Comparison with the clinical situation suggests that immune complexes are not responsible for the lesions, but that these lesions might be produced by the immunity demonstrated by the LMIT. A deficiency of this immunity is responsible for the persistence of infection. However, in chronic active hepatitis, LMIT is as deficient as in carriers and in this form of hepatitis the frequency and quantity of complexes are the highest: it is thus possible that in this case the lesions are nevertheless produced by the complexes.
D000936:Antigen-Antibody Complex; D002464:Cell Migration Inhibition; D005455:Fluorescent Antibody Technique; D006509:Hepatitis B / Q000276:immunology*; D006514:Hepatitis B Surface Antigens / Q000302:isolation & purification; D006801:Humans; D007111:Immunity, Cellular; D007962:Leukocytes / Q000276:immunology*
D000936:Antigen-Antibody Complex; D006514:Hepatitis B Surface Antigens
Comparaison entre la présence de complexes immuns circulants spécifiques et le test d'inhibition de la migration leucocytaire dans différentes formes cliniques d'hépatite B.