title: [Personal experience with high doses of 6-methylprednisolone in human renal transplantation].
abstract: Forty rejection episodes were noted in a series of 35 renal transplants. 72.5% were reversible with i.v. 1 g "boluses" of 6-methylprednisolone. Four subjects died during the post-operative period, 10 were subjected to explantation and 21 were discharged with a functioning kidney; of these, mean blood creatinine was 1.02 +/- 0.31 mg in 19. Factors other than rejection influence the results of transplantation. Gastrointestinal, metabolic and bone complications typical of protracted steroid management are examined.
mesh_terms: D000293:Adolescent; D000328:Adult; D001842:Bone and Bones / Q000473:pathology; D004064:Digestive System / Q000473:pathology; D005750:Gastric Juice / Q000378:metabolism; D006029:Glycosuria / Q000209:etiology; D006084:Graft Rejection; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology; D007165:Immunosuppression Therapy; D016030:Kidney Transplantation; D008775:Methylprednisolone / Q000008:administration & dosage* / Q000627:therapeutic use; D008875:Middle Aged; D011183:Postoperative Complications; D006435:Renal Dialysis; D014184:Transplantation, Homologous / Q000401:mortality
chemical_list: D008775:Methylprednisolone
vernacular_title: Osservazioni sulla nostra esperienze con alti dosaggi di 6-metilprednisolone nel trapianto renale umano.