title: [Experimental study of the antimicrobial effect of lysozyme in combination with antibiotics].
abstract: A synergistic effect of the antibacterial action of the lysozyme combination with various antibiotics against gram-positive and gram-negative microorganisms was found. The intensifying effect of lysozyme on its combination with antibiotics was more evident with respect to gram-positive microbes and less evident with respect to gram-negative organisms. The combinations os lysozyme with methicillin, lincomycin, oleandomycin or erythromycin proved to be most active against staphylococci. A high synergistic effect against streptococci was observed with the use of the lysozyme combination with benzylpenicillin, morphocycline, oleandomycin, ceporin or monomycin. The combination of lysozyme with macrolides had a maximum inhibitory effect on Coli bacteria.
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004357:Drug Synergism; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D009113:Muramidase / Q000494:pharmacology*; D013210:Staphylococcus / Q000187:drug effects; D013291:Streptococcus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D009113:Muramidase
vernacular_title: Eksperimental'noe izuchenie antimikrobnogo éffekta lizotsima v kombinatsii s antibiotikami.