Inhibition of human neutrophil chemotaxis by corticosteroids.
A direct inhibitory effect of hydrocortisone on granulocyte chemotaxis has been demonstrated with an increasing inhibition between concentrations of 5 microgram to 12.5 microgram per ml. Washing the granulocytes after incubation with hydrocortisone did not reverse the inhibitory effect on chemotaxis indicating a direct cellular effect. Bacteriocidal capacity of the hydrocortisone treated cells was not reduced. These studies indicate corticosteroids, alter motility of granulocytes irreversibly possibly by incorporation into the cell membrane.
D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D004731:Endotoxins / Q000494:pharmacology; D004926:Escherichia coli; D006098:Granulocytes / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology*; D007962:Leukocytes / Q000502:physiology*
D004731:Endotoxins; D006854:Hydrocortisone