[Effect of purine derivatives on regeneration and the immunologic reactivity of animals].
The effect of azathioprine and of KI-7 (the new purine derivative) on the immunogenesis and regeneration in mammals was studied comparatively, KI-7 with a lesser toxicity than azathioprine proved to suppress the synthesis of antibodies to the SRBC in mice in case of administration of the preparation one day before or on the day of immunization; it also considerably prolonged the survival of skin allografts in rabbits in comparison with control. At the same time it was shown that under conditions of suppression of the immunogenesis system hepatic regeneration did occur in rats, but the correlation of the proliferation processes and cellular hypertrophy differed from that under ordinary restoration conditions, depending on the immunodepressor used. Thus, in difference from azathioprine, KI-7 not only inhibited the mitotic activity of the regenerating liver, but even stimulated it somewhat.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D001379:Azathioprine / Q000494:pharmacology / Q000633:toxicity; D004912:Erythrocytes / Q000276:immunology; D006085:Graft Survival / Q000187:drug effects*; D006824:Hybridization, Genetic; D007166:Immunosuppressive Agents; D008115:Liver Regeneration / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011687:Purines / Q000494:pharmacology* / Q000633:toxicity; D011817:Rabbits; D012756:Sheep / Q000276:immunology; D016038:Skin Transplantation; D014184:Transplantation, Homologous
D007166:Immunosuppressive Agents; D011687:Purines; C017966:KI 7; D001379:Azathioprine
Vliianie proizvodnykh purina na regeneratsiiu i immunologicheskuiu reaktivnost' u zhivotnykh.