Physostigmine: improvement of long-term memory processes in normal humans.
Nineteen normal male subjects received 1.0 milligram of physostigmine or 1.0 milligram of saline by a slow intravenous infusion on two nonconsecutive days. Physostigmine significantly enhanced storage of information into long-term memory. Retrieval of information from long-term memory was also improved. Short-term memory processes were not significantly altered by physostigmine.
D000109:Acetylcholine / Q000502:physiology; D000293:Adolescent; D000328:Adult; D000544:Alzheimer Disease / Q000188:drug therapy; D002986:Clinical Trials as Topic; D006801:Humans; D008297:Male; D008568:Memory / Q000187:drug effects* / Q000502:physiology; D008570:Memory, Short-Term / Q000187:drug effects; D010830:Physostigmine / Q000494:pharmacology* / Q000627:therapeutic use
D010830:Physostigmine; D000109:Acetylcholine