Effect of delta9-tetrahydrocannabinol on in vitro sensitization of mouse splenic lymphocytes.
The effects of delta9-tetrahydrocannabinol (delta9-THC) on the immune response of murine cells sensitized in vitro was determined using a plaque-forming cell (PFC) assay. Splenic lymphocytes from mice injected with delta9-THC showed a depressed immunologic response when compared with cells from control animals which were identically sensitized in vitro with sheep erythrocytes (SRBC). The direct addition of delta9-THC to the culture media altered the immunological response as demonstrated by a reduction in the number of PFC.
D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology; D013759:Dronabinol / Q000494:pharmacology*; D000431:Ethanol / Q000494:pharmacology; D006462:Hemolytic Plaque Technique; D007075:Immunoglobulin M; D007166:Immunosuppressive Agents / Q000494:pharmacology; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D051379:Mice; D013154:Spleen / Q000276:immunology*
D007075:Immunoglobulin M; D007166:Immunosuppressive Agents; D000431:Ethanol; D013759:Dronabinol