title: Subsensitivity to the bronchodilator action of albuterol produced by chronic administration.
abstract: Evidence of bronchodilator subsensitivity was sought in studies using the specific beta2 adrenergic agonist, albuterol. After a period of 1 or 2 weeks off all oral sympathomimetic agents, the mean response of the patients to the first dose of albuterol was consistently greater than the response after a period during which the drug had been administered regularly. Maximal decrease in response occurred after 2 weeks' of treatment, and there was no further decrease after prolonged treatment with the same dose of albuterol for periods as long as 1 year.
mesh_terms: D000293:Adolescent; D000420:Albuterol / Q000008:administration & dosage*; D001249:Asthma / Q000188:drug therapy / Q000503:physiopathology; D001980:Bronchi / Q000187:drug effects; D002648:Child; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004361:Drug Tolerance; D005541:Forced Expiratory Volume; D006801:Humans; D008450:Maximal Midexpiratory Flow Rate; D012119:Respiration / Q000187:drug effects*
chemical_list: D000420:Albuterol