title: Effects of adrenaline and the concentration of solution on extradural block with etidocaine.
abstract: Forty patients allocated to four groups received extradural injections of etidocaine for the performance of lower abdominal surgery. Twenty millilitre of the 1% or 1.5% solutions with or without adrenaline (1:200 000) was given in a double-blind manner. The addition of adrenaline to etidocaine did not significantly prolong the duration of analgesia, but it produced significant more motor block. Etidocaine 1.5% caused significantly longer durations of analgesia and more motor block than the 1% solution. The spread of sensory analgesia was similar with all four solutions of local anaesthetic agent.
mesh_terms: D000083:Acetanilides / Q000031:analogs & derivatives; D000328:Adult; D000767:Anesthesia, Epidural / Q000379:methods*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004347:Drug Interactions; D004837:Epinephrine / Q000008:administration & dosage / Q000494:pharmacology*; D005041:Etidocaine / Q000008:administration & dosage; D005260:Female; D006801:Humans; D013997:Time Factors
chemical_list: D000083:Acetanilides; D005041:Etidocaine; D004837:Epinephrine