Cyclic thymineless death significantly increases frequency of R-plasmid elimination.
Thymine starvation of Escherichia coli strain C600 thy (R46) eliminated the R plasmid at a frequency of 17%. This was increased fourfold, to 68%, after the same culture was subjected to an additional three cycles of growth followed by thymineless death.
D004926:Escherichia coli / Q000502:physiology*; D011815:R Factors; D013941:Thymine / Q000502:physiology*; D013997:Time Factors
D013941:Thymine