Immunosuppression of mice by delta-9-tetrahydrocannabinol.
Studies were initiated to determine the effects of delta-9-tetrahydrocannibinol (THC) on the production of indirect IgG plaque-forming and rosette-forming cells in mice. BDF1 mice were immunized with sheep erythrocytes followed by multiple injections of 10, 25 or 40 mg/kg THC. Results indicated that both parameters were significantly reduced by 25 mg/kg, thus affirming the immunosuppressive properties of this substance in mice.
D000818:Animals; D013759:Dronabinol / Q000494:pharmacology*; D006462:Hemolytic Plaque Technique; D007074:Immunoglobulin G; D007166:Immunosuppressive Agents; D008297:Male; D051379:Mice; D012397:Rosette Formation
D007074:Immunoglobulin G; D007166:Immunosuppressive Agents; D013759:Dronabinol