[Comparative assessment of the efficacy in humoral response of T-cells of various organ origin and their substitutes].
A linear dependence of the response to the thymus-dependent antigen (log of the plaque-forming cell count) on the T cell dose at the initial curve section was observed in syngeneic transfer of T and B cells mixture. The exponential slope differed for T cells of different origin and could serve as the measure of helper activity. In case of an excess of T-lymphocytes the response reaches the maximum, whose level is independent of the organic origin of T cells. By the helper activity T cells are distributed in the following order: T cells of the spleen and cortisone-resistant thymocytes greater than T cells of the lymph nodes greater than cortisone-sensitive thymocytes. There was established a quantitative equivalence by the capacity to activate B cells between the T-lymphocytes and E. coli lipopolysaccharide.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D004926:Escherichia coli / Q000276:immunology; D008070:Lipopolysaccharides / Q000276:immunology*; D008198:Lymph Nodes / Q000166:cytology; D008213:Lymphocyte Activation; D051379:Mice; D008808:Mice, Inbred CBA; D009928:Organ Specificity; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000276:immunology* / Q000637:transplantation; D013950:Thymus Gland / Q000166:cytology; D014185:Transplantation, Isogeneic
D008070:Lipopolysaccharides; D011135:Polysaccharides, Bacterial
Sravnitel'naia otsenka éffektivnosti T-kletok raznogo organnogo proiskhozhdeniia i ikh zameniteleĭ v gumoral'nom otvete.