The role of prostaglandins in inflammation.
Our work suggests that aspirin-like drugs suppress inflammatory oedema not by reducing vessel wall permeability but by inhibiting the production of vasodilator mediators (prostaglandins), which results in a reduction in plasma exudation. Thus aspirin-like drugs appear to inhibit inflammatory swelling in the same manner as the traditional method of cooling with an ice-pack--by constricting the dilated blood vessels.
D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D002199:Capillary Permeability / Q000187:drug effects; D005122:Exudates and Transudates / Q000502:physiology; D006168:Guinea Pigs; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D011453:Prostaglandins / Q000096:biosynthesis / Q000494:pharmacology / Q000502:physiology*; D011817:Rabbits; D012039:Regional Blood Flow / Q000187:drug effects
D011453:Prostaglandins; D001241:Aspirin