Regranulation of islets of Langerhans and normalization of in vivo insulin secretion in ob/ob mice treated with oxytetracycline.
Oxytetracycline (OTC) treatment was associated with regranulation of the islet cells and increased pancreatic insulin content in the ob/ob mouse. This was accompanied by an improvement of the in vivo insulin secretory response to glucose. Because of the wide-ranging effects of OTC on other membrane-related functions, it is postulated that this compound may exert ist effect by altering the composition of cellular membranes.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000166:cytology / Q000187:drug effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D010118:Oxytetracycline / Q000494:pharmacology*; D010179:Pancreas / Q000032:analysis / Q000033:anatomy & histology
D001786:Blood Glucose; D007328:Insulin; D010118:Oxytetracycline