Severe aplastic anaemia with complete autologous marrow reconstitution following treatment with antithymocyte globulin. Report of a case and review of the literature.
In a patient with end-stage acquired aplastic anaemia, unsuccessful treatment with splenectomy, prednisone, pyridoxine and anabolic steroid was followed by administration of antithymocyte globulin (ATG). This therapy soon led to a gradual improvement and after 12 months, complete remission was obtained. The possible mechanism of action of ATG and the general principles of treatment are discussed.
D000328:Adult; D000741:Anemia, Aplastic / Q000628:therapy*; D000961:Antilymphocyte Serum / Q000627:therapeutic use*; D016026:Bone Marrow Transplantation; D006801:Humans; D008297:Male; D012075:Remission, Spontaneous; D013601:T-Lymphocytes / Q000276:immunology*; D014182:Transplantation, Autologous
D000961:Antilymphocyte Serum