[The effects of tolamolol on excito-conduction in men (author's transl)].
The electrophysiologic effects of tolamolol (UK-6558-01), a new beta-adrenergic blocking agent, were studied using the endocavitarian electrocardiography and the extrastimulus method. The drug was infused intravenously in the dose of 20 mg (0,23-0,36 mg per kilogram). Tolamolol resulted in: -- prolongation of sinus cycle length in 17 patients (P less than 0.001); -- prolongation of correct sinus node recovery time in 16 patients (P less than 0.001); -- there was no significant modification in intra-atrial conduction (P less than 0.3), while atrail effective refractory period was slightly lengthened (P less than 0.03); -- in A-V node conduction was prolonged in 17 patients (P less than 0.001) and the effective functional refractory periods were prolonged in all patients (P less than 0.001); -- a A-V block of 2 degrees grade appears in 17 patients at a more prolonged cycle length (P less than 0.001). Tolamolol had no effect on His-Purkinje system conduction time as well as the relative refractory period, measured before and after the drug in 2 patients. In 6 patients, during the induction of extrastimuli an "echo zone" appeared; after tolamolol its duration was reduced in 4 patients, in one unchanged and in one abolished. The therapeutical properties of this drug are discussed on the basis of such experimental data.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001145:Arrhythmias, Cardiac / Q000188:drug therapy; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D005260:Female; D006329:Heart Conduction System / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011412:Propanolamines / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D011412:Propanolamines
Effetti del tolamololo sulla eccito-conduzione nell'uomo.