title: Failure of diethylcarbamazine as a provocative test in subperiodic Wuchereria bancrofti filariasis.
abstract: The effect of diethylcarbamazine (DEC) on levels of microfilaraemia in 70 patients with subperiodic, Pacific-variant Wuchereria bancrofti infection was studied one hour after oral administration of 5 mg/kg of drug. In contrast to the immediate DEC-induced increase in microfilaraemia which had been previously described in patients with nocturnally periodic filariasis, diethylcarbamazine failed to elicit such a response in patients with subperiodic bancrofti infection. Indeed, one hour after oral DEC the number of circulating microfilariae was reduced to about 8% of pre-treatment values.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D002648:Child; D004049:Diethylcarbamazine / Q000494:pharmacology; D005260:Female; D005368:Filariasis / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010139:Pacific Islands; D010507:Periodicity; D014958:Wuchereria bancrofti / Q000187:drug effects
chemical_list: D004049:Diethylcarbamazine