The effect of 1,4-diaminobutanone on the stability of ornithine decarboxylase from Aspergillus nidulans.
1,4-Diaminobutanone, a competitive inhibitor of ornithine decarboxylase in Aspergillus nidulans, is able to increase the half-life of this enzyme and thus stimulate an increase in its activity in vivo. It also protects ornithine decarboxylase against proteolysis by chymotrypsin in vitro.
D001233:Aspergillus nidulans / Q000201:enzymology*; D002074:Butanones / Q000494:pharmacology*; D002262:Carboxy-Lyases / Q000378:metabolism*; D002918:Chymotrypsin / Q000378:metabolism; D003513:Cycloheximide / Q000378:metabolism; D004789:Enzyme Activation / Q000187:drug effects; D006207:Half-Life; D009955:Ornithine Decarboxylase / Q000378:metabolism*; D011700:Putrescine / Q000031:analogs & derivatives* / Q000494:pharmacology
D002074:Butanones; C014458:1,4-diaminobutanone; D003513:Cycloheximide; D002918:Chymotrypsin; D002262:Carboxy-Lyases; D009955:Ornithine Decarboxylase; D011700:Putrescine