Comparative study of carbuterol and salbutamol from metered aerosols in bronchial asthma.
In a double-blind crossover trial carbuterol and salbutamol were administered by aerosol for 7 days each to 20 patients with reversible obstructive airways disease. In addition to assessment of subjective response, objective measurements were made of response of the respiratory system (FEV1, FVC, MMEFR) and cardiovascular system (pulse rate, blood pressure, ECG) to each drug. Both carbuterol and salbutamol were found to be effective, well-tolerated bronchodilators when given over a 7 day period; there was no significant difference between the drugs in any of the parameters studied. Carbuterol is a safe and effective alternative to salbutamol.
D000336:Aerosols; D000420:Albuterol / Q000008:administration & dosage / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004341:Drug Evaluation; D004983:Ethanolamines / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D012129:Respiratory Function Tests
D000336:Aerosols; D004983:Ethanolamines; D000420:Albuterol