Radiation induced alterations in the endotoxin of S. typhimurium.
The lipopolysaccharide (LPS) of S. typhimurium has been shown to be significantly detoxified after in vivo irradiation at 500 krad. Radiation is thus a useful method for converting endotoxin into toxoid. The structural alterations in the detoxified LPS are shown to be mainly in the lipid A molecule, resulting in the loss of beta-hydroxymyristic acid.
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D004731:Endotoxins / Q000528:radiation effects* / Q000633:toxicity; D008070:Lipopolysaccharides / Q000528:radiation effects / Q000633:toxicity; D051379:Mice; D011135:Polysaccharides, Bacterial / Q000528:radiation effects / Q000633:toxicity; D011829:Radiation Dosage; D012486:Salmonella typhimurium
D004731:Endotoxins; D008070:Lipopolysaccharides; D011135:Polysaccharides, Bacterial