Short course of single daily dosage treatment with tinidazole and metronidazole in intestinal amoebiasis: a comparative study.
Tinidazole or metronidazole was administered at random to 56 patients with symptomatic intestinal amoebiasis. The dose of each drug given was 2 g once daily for 3 consecutive days. Tinidazole cured 92.6% patients (25/27) and metronidazole 58.6% patients (17/29). The difference was statistically significant (p less than 0.01). Tinidazole was better tolerated compared with metronidazole.
D000293:Adolescent; D000328:Adult; D002986:Clinical Trials as Topic; D004334:Drug Administration Schedule; D004404:Dysentery, Amebic / Q000188:drug therapy* / Q000469:parasitology; D005260:Female; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage* / Q000627:therapeutic use; D008875:Middle Aged; D009593:Nitroimidazoles / Q000008:administration & dosage*; D010349:Patient Compliance; D014011:Tinidazole / Q000008:administration & dosage* / Q000627:therapeutic use
D009593:Nitroimidazoles; D014011:Tinidazole; D008795:Metronidazole