title: 2 (1H)-quinazolinones as novel non-acidic anti-inflammatory agents.
abstract: Chemical modification of 1-methyl-4-phenyl-2 (1H)-quinazolinone, a new lead in the area of non-steroidal anti-inflammatory agents, has led to 1-isopropyl-4-phenyl-7-methyl-2 (1H)-quinazolinone, proquazone. The overall anti-inflammatory profile of proquazone compares well with indomethacin qualitatively and quantitatively. It is particularly noteworthy that proquazone is the first potent anti-inflammatory drug of a non-acidic nature.
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002986:Clinical Trials as Topic; D004353:Drug Evaluation, Preclinical; D007213:Indomethacin / Q000494:pharmacology; D010653:Phenylbutazone / Q000494:pharmacology; D011799:Quinazolines / Q000138:chemical synthesis / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D011799:Quinazolines; D010653:Phenylbutazone; D007213:Indomethacin