Ribonuclease activity in renal failure: evidence for toxicity.
The normal level of serum or plasma poly C-avid ribonuclease activity is 1047 +/- 247 U/mL. Serum levels increase proportionately with elevations in serum creatinine, reaching levels of 9,500-35,000 in patients undergoing dialysis. The levels can be normalised by successful renal transplantation but not by dialysis. Purified human urinary ribonuclease, a glycoprotein enzyme similar to the serum ribonuclease, was capable of: 1) inhibiting the incorporation of 3H-thymidine into mitogen-stimulated lymphocytes; 2) inhibiting the proliferation and growth of bone marrow red cell colonies; and 3) adversely affecting the growth and viability of precursor fat cells.
D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003404:Creatinine / Q000378:metabolism; D006801:Humans; D007676:Kidney Failure, Chronic / Q000201:enzymology* / Q000628:therapy; D016030:Kidney Transplantation; D008214:Lymphocytes / Q000187:drug effects; D010530:Peritoneal Dialysis; D011066:Poly C; D006435:Renal Dialysis; D012260:Ribonucleases / Q000378:metabolism* / Q000494:pharmacology; D014184:Transplantation, Homologous
D011066:Poly C; D003404:Creatinine; D012260:Ribonucleases