[Characteristics of T-cells synthesizing macrophage migration inhibition factor in an H-2 system].
Migration inhibition factor (MIF) was found to be produced by T-cells rather than B-cells as shown by the indirect macrophage migration inhibition test in the H-2 system performed with fractionated lymphocytes. MIF-producers appeared to be more sensitive than T-killer cells to the cytotoxic action of anti-theta-antibodies, plus complement. MIF synthesis by lymph node cells developed earlier after immunization than the cytotoxic activity of these cells. These findings indicated that T-cell subpopulation producing MIF differed from the cytotoxic T-lymphocytes.
D000818:Animals; D000961:Antilymphocyte Serum / Q000494:pharmacology; D001402:B-Lymphocytes / Q000378:metabolism; D003602:Cytotoxicity, Immunologic; D006183:H-2 Antigens; D006824:Hybridization, Genetic; D007106:Immune Sera / Q000494:pharmacology; D007114:Immunization; D008263:Macrophage Migration-Inhibitory Factors / Q000096:biosynthesis*; D051379:Mice; D008815:Mice, Inbred Strains; D013045:Species Specificity; D013601:T-Lymphocytes / Q000378:metabolism*
D000961:Antilymphocyte Serum; D006183:H-2 Antigens; D007106:Immune Sera; D008263:Macrophage Migration-Inhibitory Factors
Osobennosti T-kletok, sinteziruiushchikh faktor podavleniia migratsii makrofagov v sisteme H-2.