Effects of acute alcohol administration on reproductive endocrinology in the male rat.
The results of the current studies further document that acute alcohol administration markedly disrupts the function of the HPG in the male. Our results indicate that alcohol depresses serum testosterone levels and, thereby, produces clinical symptoms associated with hypoandrogenization. Moreover, our studies suggest that acute alcohol administration also affects the hypothalamic-pituitary axis by reducing serum LH levels--an effect that may represent the primary action of alcohol on the HPG.
D000818:Animals; D002369:Castration; D000431:Ethanol / Q000097:blood / Q000494:pharmacology*; D007987:Gonadotropin-Releasing Hormone / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood* / Q000378:metabolism; D008297:Male; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism; D011863:Radioimmunoassay; D051381:Rats; D013739:Testosterone / Q000097:blood*
D007987:Gonadotropin-Releasing Hormone; D000431:Ethanol; D013739:Testosterone; D007986:Luteinizing Hormone