Induction of gene conversion in Saccharomyces cerevisiae by the nitrofluran derivative furylfuramide (AF-2).
The nitrofuran derivative furylfuramide (AF-2) is known to be both mutagenic and carcinogenic in a number of test systems. In this report we show that AF-2 can also induce gene conversion in diploid yeast in a manner dependent on both duration treatment and concentration.
D000483:Alleles; D004305:Dose-Response Relationship, Drug; D005668:Furylfuramide / Q000494:pharmacology*; D009153:Mutagens; D009581:Nitrofurans / Q000494:pharmacology*; D011995:Recombination, Genetic; D012441:Saccharomyces cerevisiae
D009153:Mutagens; D009581:Nitrofurans; D005668:Furylfuramide