[Use of Hyperstat for arresting hypertensive crises].
The indices of central hemodynamics were determined in 112 patients with hypertensive disease during a crisis and in its arrest with hyperstat by means of integral rheography. The condition of the sympatheticoadrenal and kallikrein-kinin systems was studied. It was found that hyperstat normalizes arterial pressure in 5--6 minutes by reducing the initially increased general peripheral resistance and increasing the blood stroke and minute volumes as well as by reducing the content of adrenaline. The indices of the blood kallikrein-kinin system showed a tendency to return to normal values 24 hours after hyperstat administration. The drug caused no complications, only in two patients deterioration of myocardial blood supply was noted. The authors claim that hyperstat is a highly effective agent for arresting hypertensive crises.
D000311:Adrenal Glands / Q000187:drug effects; D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D003981:Diazoxide / Q000627:therapeutic use*; D004341:Drug Evaluation; D004630:Emergencies; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007610:Kallikreins / Q000097:blood; D007705:Kinins / Q000097:blood; D008297:Male; D008875:Middle Aged; D013564:Sympathetic Nervous System / Q000187:drug effects; D013997:Time Factors
D007705:Kinins; D007610:Kallikreins; D003981:Diazoxide
Primenenie giperstata dlia kupirovaniia gipertonicheskikh krizov.