Investigation of the mechanism of the metabolic activation of chloramphenicol by rat liver microsomes. Identification of a new metabolite.
D000818:Animals; D001711:Biotransformation; D002701:Chloramphenicol / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D006868:Hydrolysis; D066298:In Vitro Techniques; D008297:Male; D013058:Mass Spectrometry; D008862:Microsomes, Liver / Q000378:metabolism*; D010072:Oxamic Acid / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000378:metabolism; D011865:Radioisotope Dilution Technique; D051381:Rats
D002701:Chloramphenicol; D010072:Oxamic Acid