Inhibition by somatostatin (growth-hormone release-inhibiting hormone, GH-RIH) of gastric acid and pepsin and G-cell release of gastrin.
Somatostatin (cyclic growth-hormone release-inhibiting hormone--GH-RIH) was infused into dogs with gastric fistulae. Somatostatin inhibited gastric acid response to four gastric stimulants--insulin, food, histamine, and pentagastrin. Histamine- and pentagastrin-stimulated pepsins were inhibited similarly to inhibition of acid. Somatostatin inhibited the gastrin response to insulin and food.
D000818:Animals; D004285:Dogs; D005502:Food; D005750:Gastric Juice / Q000378:metabolism*; D005755:Gastrins / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology; D007328:Insulin / Q000494:pharmacology; D010418:Pentagastrin / Q000494:pharmacology; D010434:Pepsin A / Q000378:metabolism*; D012636:Secretory Rate / Q000187:drug effects; D013004:Somatostatin / Q000494:pharmacology*
D005755:Gastrins; D007328:Insulin; D013004:Somatostatin; D006632:Histamine; D010434:Pepsin A; D010418:Pentagastrin