title: Biochemical mechanisms of resistance to antimetabolites.
mesh_terms: D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000378:metabolism / Q000494:pharmacology*; D001692:Biological Transport; D004273:DNA, Neoplasm / Q000096:biosynthesis; D004351:Drug Resistance; D005493:Folic Acid Antagonists; D006801:Humans; D066298:In Vitro Techniques; D008727:Methotrexate / Q000378:metabolism / Q000494:pharmacology; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D013762:Tetrahydrofolate Dehydrogenase / Q000378:metabolism
chemical_list: D000964:Antimetabolites, Antineoplastic; D004273:DNA, Neoplasm; D005493:Folic Acid Antagonists; D013762:Tetrahydrofolate Dehydrogenase; D008727:Methotrexate