title: Correlation of nonsense sites in the lacI gene with specific codons in the nucleotide sequence.
abstract: Nonsense mutations derived from 90 different codons in the lacI gene of Escherichia coli have been correlated with the I gene nucleotide sequence. In over 80 cases the specific codon which generates the nonsense mutation can be identified. The sequence shows that 14-16 sites arise through tandem double base changes.
mesh_terms: D000595:Amino Acid Sequence; D000596:Amino Acids / Q000235:genetics; D001483:Base Sequence; D003062:Codon; D004926:Escherichia coli / Q000235:genetics*; D005796:Genes; D005809:Genes, Regulator; D007785:Lactose / Q000235:genetics*; D009154:Mutation; D010443:Peptide Chain Termination, Translational; D012333:RNA, Messenger
chemical_list: D000596:Amino Acids; D003062:Codon; D012333:RNA, Messenger; D007785:Lactose