Direct blockade of antigen-reactive B lymphocytes by immune complexes. An 'off' signal for precursors of IgM-producing cells provided by the linkage of antigen-and Fc-receptors.
Antigen-antibody complexes efficiently inhibit the induction of antibody formation. Using Mishell-Dutton cultures, it can be demonstrated that neither T cells nor their products are required for this inhibition of IgM PFC formation. The blockade is at the level of B cells and cannot be overcome by LPS or TRF. The data demonstrate that cross-linking of antigen- and Fc-receptors by antigen-antibody complexes is a blocking signal for B cells.
D000818:Animals; D000917:Antibody Formation; D000921:Antibody-Producing Cells / Q000276:immunology; D000936:Antigen-Antibody Complex; D001402:B-Lymphocytes / Q000276:immunology*; D001665:Binding Sites; D005260:Female; D006462:Hemolytic Plaque Technique; D007141:Immunoglobulin Fc Fragments; D007075:Immunoglobulin M / Q000096:biosynthesis; D007165:Immunosuppression Therapy; D008297:Male; D051379:Mice; D013997:Time Factors
D000936:Antigen-Antibody Complex; D007141:Immunoglobulin Fc Fragments; D007075:Immunoglobulin M