title: Diabetic regulation and its relationship to microangiopathy.
abstract: This review addresses the question of the effectiveness of rigid regulation of the blood glucose in delaying or preventing the vascular complications of diabetes mellitus. Morphometric, pathologic, biochemical, and clinical evidence on both sides of this question are presented. It is concluded that because of present inadequate methods of completely returning glucose homeostasis to normal in diabetics, the question remains moot.
mesh_terms: D000328:Adult; D001485:Basement Membrane / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism*; D002196:Capillaries / Q000378:metabolism; D003920:Diabetes Mellitus / Q000097:blood*; D003925:Diabetic Angiopathies / Q000097:blood* / Q000473:pathology / Q000517:prevention & control; D003928:Diabetic Nephropathies / Q000097:blood / Q000473:pathology; D003929:Diabetic Neuropathies / Q000097:blood; D003930:Diabetic Retinopathy / Q000097:blood; D005934:Glucagon / Q000097:blood; D006441:Hemoglobin A / Q000032:analysis; D006801:Humans; D006943:Hyperglycemia / Q000097:blood; D007328:Insulin / Q000627:therapeutic use; D007678:Kidney Glomerulus / Q000378:metabolism / Q000473:pathology; D008875:Middle Aged; D009132:Muscles / Q000098:blood supply
chemical_list: D001786:Blood Glucose; D007328:Insulin; D005934:Glucagon; D006441:Hemoglobin A