[Effect of lipid preparations isolated from protozoa on experimental leishmaniasis in golden hamsters].
The effect of lipid preparations Nos. 59 and 60 isolated from Protozoa on experimental leishmaniosis of golden hamsters was studied. Preparations Nos. 59 and 60 are water-soluble derivatives of fatty acids isolated from Trypanosoma lewisi and Astasia longa respectively. It was found that both preparations administered to the animals simultaneously with the causative agent or after formation of the leishmaniosis infiltrates inhibited the development of the disease clinical signs. Such an effect of the preparations was observed only during the period of the animals exposure to them. After discontinuation of the treatment the development of the clinical process proceeded the same as in the control animals. The lipid preparation No. 60 differing from preparation No. 59 by high content of C20-poly-unsaturated fatty acids was more active and induced a significant decrease in the size of the leishmaniosis infiltrates formed. Preparation No. 60 was more effective in the treatment of the animals infected with L. tropica major than in the animals infected with L. tropica minor. Preparation No. 59 had no significant effect on multiplication and morphology of the parazites.
D000818:Animals; D006224:Cricetinae; D004353:Drug Evaluation, Preclinical; D056890:Eukaryota / Q000302:isolation & purification*; D005260:Female; D007891:Leishmania / Q000187:drug effects; D007896:Leishmaniasis / Q000188:drug therapy*; D008055:Lipids / Q000302:isolation & purification / Q000627:therapeutic use*; D008297:Male; D008647:Mesocricetus; D012995:Solubility; D013997:Time Factors; D014350:Trypanosoma lewisi / Q000302:isolation & purification*
D008055:Lipids
Vliianie lipidnykh preparatov, vydelennykh iz prosteĭshikh, na éksperimental'nyĭ leĭshmanioz zolotistykh khomiakov.