Endotoxin-induced interruption of early pregnancy in the rabbit.
Endotoxin derived from Salmonella enteritidis (Boivin) completely interrupted pregnancy in the rabbit when given as a single dose (10 or 20 microgram/kg) intravenously on Day 4 or Day 8 of pregnancy. Indomethacin (2 or 10 mg/kg) was unable to prevent this effect.
D000019:Abortifacient Agents; D000020:Abortifacient Agents, Nonsteroidal; D000818:Animals; D004731:Endotoxins / Q000494:pharmacology*; D005260:Female; D007213:Indomethacin / Q000494:pharmacology; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D011817:Rabbits; D012477:Salmonella enteritidis
D000019:Abortifacient Agents; D000020:Abortifacient Agents, Nonsteroidal; D004731:Endotoxins; D007213:Indomethacin