Calcium-antagonists and islet function X. Effect of suloctidie.
Suloctidil (0.5 to 5.0 micrometer) inhibits insulin release evoked by glucose or alpha-ketoisocaproate in pancreatic islets. The drug also inhibits basal and glucose-stimulated 45calcium net uptake by the islets. In an artificial system, suloctidil inhibits A23187-mediated calcium translocation. It is proposed that the inhibitory action of suloctidil upon islet function may be due to interference with B-cell native ionophoretic system(s).
D000001:Calcimycin / Q000494:pharmacology; D002118:Calcium / Q000037:antagonists & inhibitors*; D002132:Calcium Radioisotopes; D002208:Caproates / Q000494:pharmacology; D004347:Drug Interactions; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism*; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism*; D011412:Propanolamines / Q000494:pharmacology*
D002132:Calcium Radioisotopes; D002208:Caproates; D007328:Insulin; D011412:Propanolamines; D000001:Calcimycin; D002118:Calcium