[Immunodepressive activity of cell fractions of Escherichia coli O138:K81:H19].
A soluble cell fraction (cytosol), an O-antigen (endotoxin), and an unsoluble cell ingredient were isolated from a 24-hour culture of Escherichia coli O138:K81:H19. Their immunosuppressive action was determined by using the tuberculin test and the survival rate of the allographts. It was found that: 1. Cytosol appears to be a slightly toxic preparation with well expressed immunosuppressive action. 2. The endotoxin is highly toxic, producing the same effect as cytosol. 3. The unsoluble cell ingredient is a comparatively toxic preparation, producing an undependable immunosuppressive effect. Discussed is the mechanism of the immunosuppressive activity of the investigated subcellular fractions. It believed to be due to a certain injurious action on the function of the T-cells.
D000818:Animals; D000942:Antigens, Bacterial; D003593:Cytoplasm / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D004926:Escherichia coli / Q000276:immunology*; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D013347:Subcellular Fractions / Q000276:immunology; D014184:Transplantation, Homologous; D014374:Tuberculin Test
D000942:Antigens, Bacterial; D007166:Immunosuppressive Agents
Imunodepresivna aktivnost na kletuchni fraktsii ot Escherichia coli O138:K81:H19.