title: Alterations in pulmonary function of premature lambs due to positive end-expiratory pressure.
abstract: These studies compare lung mechanics and volumes of premature lambs delivered at 139 days of gestation by cesarean section and ventilated by either intermittent positive pressure (IPP) or positive end-expiratory pressure (PEEP). During the first few hours of life, sequential determinations of lung compliance, specific lung compliance; lung resistance, specific lung conductance and functional residual capacity were made at half-hour intervals. Measurements in 5 lambs ventilated with PEEP demonstrated that lung compliance (p less than 0.005), specific lung compliance (p less than 0.001) and specific lung conductance (p less than 0.005) decreased; while lung resistance (p less than 0.10) and functional residual capacity (p less than 0.02) increased as compared to 7 lambs ventilated with IPP.
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001784:Blood Gas Analysis; D005652:Functional Residual Capacity; D008170:Lung Compliance; D011175:Positive-Pressure Respiration; D012129:Respiratory Function Tests; D012756:Sheep