Monovalent inactivated A/New Jersey/8/76 (Hsw1N1) vaccine in healthy children aged three to five years.
Single doses (50, 100, or 200 chick cell-agglutinating [CCA] units) of split-product or whole-virus (50 or 100 CCA units), monovalent inactivated A/New Jersey/8/76 (Hsw1n1) virus vaccine or placebo were given to healthy children aged three to five years in Maryland. Split-product vaccine was nonreactogenic but also virtually nonimmunogenic. Lower doses of whole-virus vaccine (50 CCA units of Merck, Sharp and Dohme [West Point, Pa.] and 50 or 100 CCA units of Merrell-National Laboratories [Cincinnati, Ohio] vaccine) were mildly reactogenic (approximately 25% of the children had low-grade fevers of 100 F-101 F). These dosage levels of whole-virus vaccine stimulated titers of greater than or equal to 1:20 in 68% and titers of greater than or equal to 1:40 in 37% of the children. Two inoculations of whole-virus vaccine (primary immunization followed by a booster one month later) were tolerated and induced titers of greater than or equal to 1:80 in 100% of the children.
D002675:Child, Preschool; D002986:Clinical Trials as Topic; D004306:Dose-Response Relationship, Immunologic; D004311:Double-Blind Method; D006801:Humans; D009980:Influenza A virus / Q000276:immunology*; D007252:Influenza Vaccines / Q000494:pharmacology*; D009515:New Jersey
D007252:Influenza Vaccines