title: Effects of alexidine.2HCL mouthwash on plaque and gingivitis after six months.
abstract: Two-hundred and fourteen subjects ranging in age from 22 to 63 years used either a mouthwash that contained 0.035% w/v alexidine.2HCL (2-ethylhexyl bisbiguanidine dihydrochloride) or a placebo twice daily on a doubleblind basis for six months in conjunction with routine oral hygiene procedures. The results indicated that alexidine.2HCL was safe and was statistically more effective in producing a clinically significant reduction in gingivitis than was the placebo.
mesh_terms: D000328:Adult; D001645:Biguanides / Q000009:adverse effects / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003116:Color; D003188:Composite Resins; D003773:Dental Plaque / Q000032:analysis / Q000517:prevention & control*; D004311:Double-Blind Method; D004341:Drug Evaluation; D005260:Female; D005891:Gingivitis / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009067:Mouthwashes / Q000009:adverse effects / Q000627:therapeutic use*; D010919:Placebos; D012823:Silicate Cement; D013997:Time Factors; D014059:Tongue / Q000033:anatomy & histology; D014075:Tooth Discoloration / Q000139:chemically induced / Q000628:therapy; D014099:Toothbrushing
chemical_list: D001645:Biguanides; D003188:Composite Resins; D009067:Mouthwashes; D010919:Placebos; D012823:Silicate Cement