title: Treatment of peptic ulcer in renal failure.
abstract: The occurrence and pathophysiology of peptic ulcer was studied in 117 uraemic patients. Ulcer disease was unusually frequent, and the highest incidence was found in patients on regular dialysis (48%). Factors implicated were hyperacidity, hypergastrinaemia, and the effect of dialysis itself. We found that the occurrence of gastrointestinal bleeding was lower post-transplant (7%), than pre-transplant (15%), and that bleeding in renal transplant patients was due more commonly to erosive gastritis than peptic ulcer. Cimetidene was given to 9 regular dialysis patients with peptic ulcer. Symptomatic relief and significant reduction of acid secretion was demonstrated, and no major side effects occured. There is a logical basis for conservative treatment of uncomplicated peptic ulcer in the dialysis patient, and further evaluation of cimetidene is indicated.
mesh_terms: D002927:Cimetidine / Q000627:therapeutic use; D004381:Duodenal Ulcer / Q000150:complications / Q000628:therapy; D005260:Female; D005750:Gastric Juice / Q000378:metabolism; D005756:Gastritis / Q000150:complications; D006471:Gastrointestinal Hemorrhage / Q000150:complications; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications*; D016030:Kidney Transplantation; D008297:Male; D010437:Peptic Ulcer / Q000150:complications / Q000628:therapy*; D006435:Renal Dialysis; D014184:Transplantation, Homologous
chemical_list: D002927:Cimetidine