Impairment of the hypothalamo-pituitary-ovarian axis of the athymic "nude" mouse.
Pituitary and serum levels of LH and FSH and hypothalamic GnRH content were measured in acyclic, congenitally athymic (nu/nu) female mice. No significant differences were found between athymic and normal dioestrous mice of the same age (3 months). The serum LH level of the athymic mouse failed to increase 6 days after ovariectomy, but increased in response to injection of GnRH. The results suggest that the athymic nude mice suffer from impairment of hypothalamic control of the pituitary.
D000818:Animals; D001927:Brain Diseases / Q000150:complications; D002369:Castration; D005260:Female; D005640:Follicle Stimulating Hormone / Q000032:analysis / Q000097:blood; D007030:Hypothalamo-Hypophyseal System; D007031:Hypothalamus / Q000032:analysis; D007986:Luteinizing Hormone / Q000032:analysis / Q000097:blood; D051379:Mice; D008819:Mice, Nude; D010049:Ovarian Diseases / Q000209:etiology*; D010903:Pituitary Gland, Anterior / Q000032:analysis / Q000187:drug effects; D010906:Pituitary Hormone-Releasing Hormones / Q000032:analysis / Q000494:pharmacology; D013950:Thymus Gland / Q000502:physiology
D010906:Pituitary Hormone-Releasing Hormones; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone