Repair deficient human disorders and cancer.
The analysis of the repair of damage to DNA in mammalian cells leads not only to a knowledge of which environmental agents are deleterious to living creatures, but also to an understanding of which reaction products in DNA are potentially carcinogenic and which tissues are the more sensitive.
D000015:Abnormalities, Multiple / Q000378:metabolism; D000741:Anemia, Aplastic / Q000378:metabolism*; D001260:Ataxia Telangiectasia / Q000150:complications / Q000378:metabolism*; D002454:Cell Differentiation; D002471:Cell Transformation, Neoplastic; D004260:DNA Repair; D004392:Dwarfism / Q000378:metabolism; D005199:Fanconi Anemia / Q000378:metabolism*; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000209:etiology / Q000378:metabolism*; D011839:Radiation, Ionizing; D013577:Syndrome; D013684:Telangiectasis / Q000150:complications / Q000378:metabolism; D014466:Ultraviolet Rays; D014983:Xeroderma Pigmentosum / Q000150:complications / Q000378:metabolism*