Immunochemical analysis of the monoclonal paraprotein in scleromyxedema.
The monoclonal paraprotein from a typical case of scleromyxedema was isolated and characterized. The isolated paraprotein was of the IgG-lambda class, with a molecular weight of approximately 110,000 daltons compared with 160,000 daltons for normal IgG. Immunochemical studies indicated that the paraprotein was an incomplete IgG molecule which was missing a significant antigenic portion of the Fd fragment.
D000328:Adult; D005260:Female; D006801:Humans; D007128:Immunoglobulin Fragments; D007074:Immunoglobulin G / Q000032:analysis* / Q000302:isolation & purification; D007158:Immunologic Techniques; D008970:Molecular Weight; D010266:Paraproteins / Q000032:analysis* / Q000302:isolation & purification; D012871:Skin Diseases / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology
D007128:Immunoglobulin Fragments; D007074:Immunoglobulin G; D010266:Paraproteins