title: Studies on the heterophile antibodies of infectious mononucleosis. I. Separation of four antibody populations, one of which contains lymphocytotoxic activity.
abstract: With the aid of insolubilized immunoadsorbents made with glycoproteins, extracted from cow red blood cells (RBC), and with guinea-pig kidney tissue, heterophile antibody populations of the Paul--Bunnell type and the Forssman type were eluted from infectious mononucleosis sera. Two Paul--Bunnell-type antibody populations were separated on the basis of their affinity for cow RBC antigens. The lymphocytotoxic antibodies in the infectious mononucleosis sera were eluted among the low-affinity Paul--Bunnell antibodies.
mesh_terms: D000328:Adult; D000910:Antibodies, Heterophile / Q000302:isolation & purification*; D002846:Chromatography, Affinity / Q000379:methods; D003602:Cytotoxicity, Immunologic; D005260:Female; D005577:Forssman Antigen; D006386:Hemagglutination Tests; D006801:Humans; D007163:Immunosorbent Techniques; D007244:Infectious Mononucleosis / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology; D008297:Male
chemical_list: D000910:Antibodies, Heterophile; D005577:Forssman Antigen