Pathogenesis of congenital malformations. An hypothesis.
An hypothesis of neural crest injury, derived from a radiologic analysis of thalidomide deformities, is suggested as a possible pathogenetic mechanism of dysmelia and its associated visceral defects. Supportive evidence from a variety of sources is presented, and the hypothesis is shown to provide a unifying concept for a number of previously unrelated facts.
D000014:Abnormalities, Drug-Induced / Q000209:etiology; D000818:Animals; D001842:Bone and Bones / Q000002:abnormalities / Q000000981:diagnostic imaging / Q000294:innervation; D000013:Congenital Abnormalities / Q000209:etiology*; D005260:Female; D005727:Ganglia, Spinal / Q000196:embryology; D006801:Humans; D017880:Limb Deformities, Congenital; D011247:Pregnancy; D011859:Radiography; D013792:Thalidomide / Q000009:adverse effects
D013792:Thalidomide