Differential effect of D-glucose anomers on proinsulin biosynthesis by the pancreatic islets.
Pancreatic islets of Langerhans of the rat were used to study effects of D-glucose anomers on the incorporation of [3H]leucine into proinsulin and other islet proteins. At low (1 mg/ml), but not at high (2 mg/ml) glucose concentration, the alpha-anomer stimulated more proinsulin biosynthesis than the beta-anomer. This observation adds to the growing list of islet functions showing anomeric preference for alpha-D-glucose.
D000818:Animals; D005947:Glucose / Q000494:pharmacology*; D066298:In Vitro Techniques; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism*; D007536:Isomerism; D008297:Male; D011384:Proinsulin / Q000096:biosynthesis*; D051381:Rats; D013329:Structure-Activity Relationship
D011384:Proinsulin; D005947:Glucose