title: Some aspects of protein folding.
abstract: The mechanisms by which a polypeptide chain reaches the three dimensional structure which generates its functional properties are not yet totally understood. The great amount of data now available in the field of protein structure and the data already obtained on protein folding by in vitro experiments allow some schematic representation as, at least, a working hypothesis. In this respect the emphasis is put on the hierarchy in protein structure and the possibility of a folding by stages, some elements or "building blocks" being able to reach independently a native structure and to refine this structure by interacting with each other in the whole molecule.
mesh_terms: D003208:Concanavalin A; D003461:Crystallography; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases; D007700:Kinetics; D008956:Models, Chemical; D008961:Models, Structural; D010196:Pancreatic Elastase; D010441:Peptide Chain Elongation, Translational; D014176:Protein Biosynthesis; D011487:Protein Conformation; D011498:Protein Precursors / Q000096:biosynthesis; D012270:Ribosomes / Q000378:metabolism; D013329:Structure-Activity Relationship; D013816:Thermodynamics; D014305:Triose-Phosphate Isomerase
chemical_list: D011498:Protein Precursors; D003208:Concanavalin A; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases; D010196:Pancreatic Elastase; D014305:Triose-Phosphate Isomerase