title: Influence of calcium, magnesium, lanthanum and A23187 on the aggregation of polymorphonuclear neutrophils.
abstract: Chemotactic factors transiently aggregate human polymorphonuclear neutrophils. We have found that the aggregation induced by the chemotactic tripeptide, formyl-methionyl-leucyl-phenylalanine, depends on the extracellular calcium and magnesium concentrations and is inhibited by 1 and 10 M lanthanum chloride. The ionophore A23187 and 1 and 0.1 mM lanthanum chloride aggregate the cells. A23187-induced aggregation is dependent on extracellular calcium and magnesium whereas lanthanum-induced aggregation is not.
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000001:Calcimycin / Q000494:pharmacology*; D002118:Calcium / Q000494:pharmacology*; D002413:Cations, Divalent; D002449:Cell Aggregation / Q000187:drug effects; D005966:Glucuronidase / Q000378:metabolism; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D007811:Lanthanum / Q000494:pharmacology*; D008274:Magnesium / Q000494:pharmacology*; D009504:Neutrophils / Q000187:drug effects*; D010649:Phenylalanine / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D002413:Cations, Divalent; D000001:Calcimycin; D010649:Phenylalanine; D007811:Lanthanum; D007770:L-Lactate Dehydrogenase; D005966:Glucuronidase; D008274:Magnesium; D002118:Calcium