title: Assignment of the structural genes for the alpha subunit of hexosaminidase A, mannosephosphate isomerase, and pyruvate kinase to the region q22-qter of human chromosome 15.
abstract: Concordant segregation of the expression of the alpha subunit of human hexosaminidase A, human mannosephosphate isomerase, and pyruvate kinase was observed in somatic cell hybrids between either thymidine kinase-deficient mouse cells or thymidine kinase-deficient Chinese hamster cells and human white blood cells carrying a translocation of the distal half (q 22-qter) of the long arm of chromosome 15 to chromosome 17. A positive correlation was established between the expression of these human phenotypes and the presence of the distal half of the long arm of human chromosome 15.
mesh_terms: D002238:Carbohydrate Epimerases / Q000235:genetics*; D002901:Chromosomes, Human, 13-15; D005796:Genes; D008040:Genetic Linkage; D006596:Hexosaminidases / Q000235:genetics*; D006801:Humans; D006822:Hybrid Cells; D008359:Mannose-6-Phosphate Isomerase / Q000235:genetics*; D011770:Pyruvate Kinase / Q000235:genetics*; D014178:Translocation, Genetic; D001613:beta 2-Microglobulin / Q000235:genetics
chemical_list: D001613:beta 2-Microglobulin; D011770:Pyruvate Kinase; D006596:Hexosaminidases; D002238:Carbohydrate Epimerases; D008359:Mannose-6-Phosphate Isomerase