A radioimmunoassay of the pregnancy-specific beta1-glycoprotein (SP1).
A radioimmunological method for determination of the pregnancy specific beta1-glycoprotein (SP1) is described. Antigen specificity of rabbit anti-human SP1 serum (Behringwerke) was investigated against human placental and pituitary hormones. The sensitivity was about 10 microgram/l. The concentration ranges of SP1 in umbilical cord blood and amniotic fluid were 0.10--0.60 mg/l and 0.3--3.8 mg/l, respectively. A good correlation (r = +0.95) was found between the radioimmunological and electroimmunological methods for determination of SP1 in maternal blood.
D000653:Amniotic Fluid / Q000276:immunology*; D005260:Female; D005312:Fetal Blood / Q000276:immunology*; D006023:Glycoproteins / Q000276:immunology*; D006801:Humans; D007106:Immune Sera; D007123:Immunoelectrophoresis, Two-Dimensional; D007163:Immunosorbent Techniques; D007457:Iodine Radioisotopes; D010908:Pituitary Hormones, Anterior / Q000276:immunology; D011247:Pregnancy; D011863:Radioimmunoassay / Q000379:methods*
D006023:Glycoproteins; D007106:Immune Sera; D007457:Iodine Radioisotopes; D010908:Pituitary Hormones, Anterior