Immunofluorescence studies of intra cytoplasmic immunoglobulin binding lymphoid cells (CILC) in the central nervous system. Report of 32 cases including 19 multiple sclerosis.
In 32 cases of human neurological disorders, including 19 cases of Multiple Sclerosis, an analysis was performed on formalin fixed paraffin embedded brain tissue by using fluorescein labelled antibodies and Nomarski optics. This method, which allows the reduction of technical artifarcts, permitted to establish the presence of intracytoplasmic immunoglobulin binding lymphoid cells with IgG and IgA, more rarely IgM, in the majority of the multiple sclerosis cases. This supports the theory of the intrathecal secretion of antibodies within the central nervous system but does not allow to explain the function of those B. Lymphocytes. The same immunological picture was found in Subacute Sclerosing Panencephalitis. On the contrary, it was different in Progressive Multifocal Leucoencephalopathy.
D000328:Adult; D000368:Aged; D001666:Binding Sites, Antibody; D001921:Brain / Q000276:immunology*; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism*; D007074:Immunoglobulin G / Q000378:metabolism*; D007075:Immunoglobulin M / Q000378:metabolism*; D007968:Leukoencephalopathy, Progressive Multifocal / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000276:immunology*; D010950:Plasma Cells / Q000276:immunology; D013344:Subacute Sclerosing Panencephalitis / Q000276:immunology
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M