The genetics of diabetes mellitus.
Diabetes mellitus is a geneticist's nightmare. We examine herein what causes the nightmare, how bad it is and how it is being alleviated by modern advances. Diabetes is more than one disease, it is indefinable, probably genetically multifactorial, and presents several facets with varying degrees of heredity and environment in their constitution.
D000818:Animals; D002869:Chromosome Aberrations / Q000235:genetics; D025063:Chromosome Disorders; D002906:Chromosomes, Human, 6-12 and X; D003327:Coronary Disease / Q000453:epidemiology; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000145:classification / Q000235:genetics*; D003921:Diabetes Mellitus, Experimental; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics; D003925:Diabetic Angiopathies / Q000150:complications; D003929:Diabetic Neuropathies / Q000150:complications; D005006:Ethnicity; D005260:Female; D005817:Genetic Counseling; D005858:Germany; D013006:Growth Hormone / Q000172:deficiency; D006680:HLA Antigens / Q000235:genetics; D049673:History, 20th Century; D006801:Humans; D006943:Hyperglycemia / Q000150:complications; D007328:Insulin / Q000097:blood; D007329:Insulin Antagonists / Q000378:metabolism; D008060:Lipodystrophy / Q000150:complications; D008661:Metabolism, Inborn Errors / Q000150:complications; D009765:Obesity; D010179:Pancreas / Q000473:pathology; D011247:Pregnancy; D044469:Racial Groups; D014310:Triplets; D014430:Twins, Monozygotic; D014481:United States; D014652:Vascular Diseases / Q000453:epidemiology; D014898:Werner Syndrome / Q000150:complications
D006680:HLA Antigens; D007328:Insulin; D007329:Insulin Antagonists; D013006:Growth Hormone