Familial primary cutaneous amyloidosis. Clinical, genetic, and immunofluorescent studies.
Familial primary cutaneous amyloidosis, a rare, autosomal dominant genodermatosis, affected 16 of 46 family members of German descent. Previous case reports involved families of Russian, Spanish, or Chinese descent. The finding of IgG, IgM, C3 in the amyloid deposits confirms recent reports of immunofluorescent dermal amyloid deposits.
D000293:Adolescent; D000686:Amyloidosis / Q000150:complications / Q000235:genetics*; D003876:Dermatitis, Atopic / Q000150:complications; D005260:Female; D005453:Fluorescence; D005455:Fluorescent Antibody Technique; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D008875:Middle Aged; D012871:Skin Diseases / Q000150:complications / Q000235:genetics*
D006680:HLA Antigens