[Correction of a T-immunodeficit in mice by bone marrow transplantation from donors treated with hydrocortisone].
Adult CBA mice were exposed to thymectomy, lethal irradiation, and protection by syngeneic bone marrow transplantation. In some experiments syngeneic bone marrow of donors, treated with hydrocortisone in a dose of 125 mg/kg for 3 days was used. The bone marrow of these donors contained cells with the Q-marker. Thymectomized and lethally irradiated animals subjected to the transplantation of syngeneic bone marrow from hydrocortisone-treated donors rejected the skin allotransplants, and the lymph node cells of these mice suppressed the endogenous colony-formation in the sublethally-irradiated hybrids (CBA X C57Bl/6) F1.
D000818:Animals; D016026:Bone Marrow Transplantation; D006824:Hybridization, Genetic; D006854:Hydrocortisone / Q000627:therapeutic use*; D007153:Immunologic Deficiency Syndromes / Q000628:therapy*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013601:T-Lymphocytes; D014181:Transplantation Immunology; D014184:Transplantation, Homologous
D006854:Hydrocortisone
Korrektsiia T-immunodefitsita u mysheĭ transplantatsieĭ kostnogo mozga donorov, obrabotannykh gidrokortizonom.