Calcium antagonists and islet function. XI. Effect of nifedipine.
Nifedipine inhibits calcium-45 net uptake and glucose-induced insulin release in rat pancreatic islets, without affecting glucose oxidation and calcium-45 efflux. These findings are compatible with the view that nifedipine inhibits the entry of calcium in the B cell, by interfering with the plasma membrane ionophoretic channels.
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D003864:Depression, Chemical; D005260:Female; D005947:Glucose / Q000378:metabolism; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000378:metabolism*; D009543:Nifedipine / Q000494:pharmacology*; D011725:Pyridines / Q000494:pharmacology*; D051381:Rats
D007328:Insulin; D011725:Pyridines; D009543:Nifedipine; D005947:Glucose; D002118:Calcium