[The effects of heparin in underdevelopment of the fetus due to maternal vascular conditions (author's transl)].
The use of heparin to interfere with the appearance of fetal maldevelopment (or to correct it) is logical but the results are difficult to prove because it is difficult to be certain of early diagnosis at the time when therapy has the best chances of being efficacious. The authors compare two groups of pregnant women in whom the muscular vascular tone of the cervix is abolished. The second group was treated with heparin. The results are statistically significant and prove that treatment with heparin is well based in cases of underdevelopment of the fetus when it is due to abnormalities in the maternal microscopic circulation (acute atherosis). They confirm that the enzyme, hormone and ultrasound parameters return to normal from the beginning of treatment with heparin.
D001161:Arteriosclerosis / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D003404:Creatinine / Q000652:urine; D004798:Enzymes / Q000032:analysis; D004964:Estriol / Q000652:urine; D005260:Female; D005317:Fetal Growth Retardation / Q000188:drug therapy*; D006801:Humans; D008833:Microcirculation; D010920:Placenta / Q000098:blood supply; D010922:Placenta Diseases / Q000188:drug therapy*; D010928:Placental Lactogen / Q000032:analysis; D011247:Pregnancy; D014463:Ultrasonography
D004798:Enzymes; D010928:Placental Lactogen; D003404:Creatinine; D004964:Estriol
Effets de l'héparine dans l'hypotrophie foetale d'origine vasculaire maternelle.