[Effect of serum fractions from cancer patients on leukocyte migration out of capillary tubes].
Blood serum of patients suffering from cancer of the stomach and urinary bladder inhibited in vitro migration of autologous leukocytes, leukocytes of donors and control patients, and also guinea pig macrophages in over half of cases. In chromatography of these sera on Sephadex G-100 the activity inhibiting the leukocyte migration was revealed in fraction I (Mol. wt. over 100000) and in fractions IV and V (Mol. wt under 30 000). The blood serum and its fractions from cancer patients failed to eliminate the leukocyte migration inhibition caused by the tumour antigens in comparison with the leukocyte migration in the medium with control serum without any antigens. As suggested, the activity of fraction I inhibiting the leukocyte migration was due to the antigen-antibody complex, and of fraction IV and V--to a factor similar by its properties to the factor produced in vitro by lymphocytes stimulated by the antigens or mitogens.
D002465:Cell Movement; D002852:Chromatography, Ion Exchange; D006801:Humans; D007106:Immune Sera / Q000494:pharmacology*; D007962:Leukocytes; D008222:Lymphokines / Q000097:blood; D008263:Macrophage Migration-Inhibitory Factors / Q000097:blood; D008264:Macrophages; D013274:Stomach Neoplasms / Q000097:blood*; D001749:Urinary Bladder Neoplasms / Q000097:blood*
D007106:Immune Sera; D008222:Lymphokines; D008263:Macrophage Migration-Inhibitory Factors
Vliianie fraktsiĭ syvorotki krovi bol'nykh rakom na migratsiiu leĭkotsitov iz kapilliarnykh trubok.