title: The effect of the electron affinic sensitizers Ro 07-0582 and Ro 03-6156 on the survival of several E. coli mutants.
abstract: Concentration versus radiosensitizing effect curves have been determined for four E. coli strains with two nitroaromatic sensitizers. The data are consistent with a simple competition kinetic model of sensitization, and K values for Ro 07-0582 are reported. An empirical relationship, DMF=alpha o.e.r., relating the dose-modifying factor produced by a given concentration of sensitizer to the oxygen-enhancement ratio of a bacterium was found to hold for all the mutants tested for values of alpha greater than 1/o.e.r. The limiting value of alpha at high concentrations of sensitizer was 0.75. Some implications of this relationship and the limiting value of alpha are discussed.
mesh_terms: D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli; D009154:Mutation; D009593:Nitroimidazoles / Q000494:pharmacology*; D010100:Oxygen; D011427:Propiophenones / Q000494:pharmacology*; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*
chemical_list: D009593:Nitroimidazoles; D011427:Propiophenones; D011838:Radiation-Sensitizing Agents; D010100:Oxygen