Chloramphenicol for oral treatment of canine urinary tract infections.
Chloramphenicol was administered orally for 7 to 14 days to 83 dogs with urinary tract infections. The daily dosage of 99 mg/kg (45 mg/lb) was divided into 3 equal parts and administered at 8-hour intervals. Response to treatment (negative urine culture after treatment) varied from 84% (11 to 13) for infections caused by Staphylococcus aureus to 51% (24 of 47) for those caused by Escherichia coli; 82% (14 of 17) of the infections caused by Streptococcus spp and 63% (7 of 11) of those caused by Proteus mirabilis responded to treatment. These 4 species comprised 88% of the bacteria isolated from the dogs.
D000284:Administration, Oral; D000818:Animals; D002701:Chloramphenicol / Q000008:administration & dosage* / Q000627:therapeutic use; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004927:Escherichia coli Infections / Q000188:drug therapy / Q000662:veterinary; D011512:Proteus Infections / Q000188:drug therapy / Q000662:veterinary; D011513:Proteus mirabilis; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000662:veterinary; D014552:Urinary Tract Infections / Q000188:drug therapy / Q000662:veterinary*
D002701:Chloramphenicol