Dissociation of responses to extracellular thirst stimuli following zona incerta lesions.
In male albino rats, bilateral lesions in the anterior zona incerta which decrease ad lib and food-deprivation water intake and osmotic thirst but leave hypovolemic thirst intact, severely impaired or abolished drinking in response to systemic injections of isoproterenol or central administration of angiotensin II. Water intake following water deprivation was reduced by one-fourth. Reasons for the dissociation of responses to hypovolemia, water deprivation, isoproterenol and angiotensin were suggested.
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D001930:Brain Injuries; D004326:Drinking / Q000187:drug effects*; D007545:Isoproterenol / Q000494:pharmacology*; D008297:Male; D051381:Rats; D013238:Stereotaxic Techniques; D013894:Thirst / Q000187:drug effects / Q000502:physiology*; D014868:Water Deprivation
D000804:Angiotensin II; D007545:Isoproterenol