title: The effect of metoprolol on IOP (author's transl).
abstract: The beta1-selective beta-blocking agent Metoprolol gave a significant intraocular pressure decrease in different groups of open angle glaucoma patients in a concentration of 1% and 3%. The magnitude of effect corresponded to 33% of the untreated pressure level. The maximum of the therapeutic response occured within 4 hrs after local application of the drug. A significant IOP decrease could be observed over 8 hrs after single application. There was no more effect after 24 hrs. Metoprolol eye drops did not affect pupillary diameter, pulse rate or blood pressure. The drug was tolerated well in all patients tested both subjectively and objectively after a single topical application.
mesh_terms: D002908:Chronic Disease; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005901:Glaucoma / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008790:Metoprolol / Q000008:administration & dosage / Q000494:pharmacology*; D009883:Ophthalmic Solutions; D011412:Propanolamines / Q000494:pharmacology*; D013644:Tartrates / Q000494:pharmacology
chemical_list: D009883:Ophthalmic Solutions; D011412:Propanolamines; D013644:Tartrates; D008790:Metoprolol
vernacular_title: Die Wirkung von Metoprololtartrat auf den Augendruck. Eine Doppelblindstudie der Dosis-Wirkungs-Beziehungen.