title: [Effect of apressin and its combination with obzidan on central hemodynamic indices in the treatment of hypertension].
abstract: Apressine, obsidan and a combination of these two drugs were used for treating 44 patients suffering from hypertension, mainly stage IIB. When apressine was used to treat patients with the hypodynamic type of circulation, arterial pressure decreased due to considerable diminution of the arterial tone. Tachycardia developed simultaneously and the cardiac output increased, which restrained the hypotensive effect of apressine. The addition of the beta-blocking agent obsidan corrected, while its preliminary prescription prevented the development of the noted reflex stimulation of cardiac activity. This made it possible for the main valuable properties of apressine to become manifest, namely those which reduced the tone of the arteries and produced the hypotensive effect. Small doses of apressine and of the beta-blocking agent may be used and prolonged treatment applied with no side-effects.
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D003971:Diastole / Q000187:drug effects; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006830:Hydralazine / Q000627:therapeutic use*; D006973:Hypertension / Q000188:drug therapy*; D008875:Middle Aged; D011433:Propranolol / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D006830:Hydralazine; D011433:Propranolol
vernacular_title: Vliianie apressina i ego kombinatsii sobzidanom na pokazateli tsentral'noĭ gemodinamiki pri lechenii bol'nykh gipertonicheskoĭ bolezn'iu.