Analgesia after operation. A controlled comparison of meptazinol, pentazocine and pethidine.
In a double-blind investigation of the efficacy on pain following abdominal or orthopaedic surgery, meptazinol 100 mg, a new hexahydroazepine derivative, was found to be equipotent with pentazocine 60 mg and pethidine 100 mg when given i.m. Analgesia was maximal 30-60 min after injection and was still present at the end of 2 h. The duration of action of meptazinol was estimated to be 4 h. Meptazinol produced less sedation and a greater sparing of lung function tests than did pethidine and pentazocine. When meptazinol or morphine was administered for further pain relief in a single-blind manner there was no evidence of patient preference for one drug or the other.
D000328:Adult; D000368:Aged; D000700:Analgesics / Q000494:pharmacology; D001381:Azepines / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003243:Consciousness; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008614:Meperidine / Q000627:therapeutic use*; D008875:Middle Aged; D010149:Postoperative Pain / Q000188:drug therapy*; D010423:Pentazocine / Q000627:therapeutic use*; D012119:Respiration / Q000187:drug effects; D013997:Time Factors
D000700:Analgesics; D001381:Azepines; D008614:Meperidine; D010423:Pentazocine