In vitro studies on microphage functions in chronic pyoderma vegetans.
The function of microphages has been studied in two patients with chronic pyoderma vegetans by in vitro determination of phagocytosis as well as chemotaxis. The results showed a striking decrease in the chemotactic activity of the neutrophil granulocytes, a reduced phagocytosis of Candida albicans and Staphylococcus aureus, and a weakness of the intracellular killing of these microorganisms. However, the NADH-dependent oxidase activity appeared to be intact. No defect was found in the specific cellular or humoral immune system in either patient.
D000328:Adult; D002176:Candida albicans / Q000276:immunology; D002634:Chemotaxis, Leukocyte; D002908:Chronic Disease; D006801:Humans; D008297:Male; D009246:NADH Tetrazolium Reductase / Q000378:metabolism; D009504:Neutrophils / Q000201:enzymology; D009580:Nitroblue Tetrazolium; D010586:Phagocytes / Q000502:physiology*; D010587:Phagocytosis; D011711:Pyoderma / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D013211:Staphylococcus aureus / Q000276:immunology
D009580:Nitroblue Tetrazolium; D009246:NADH Tetrazolium Reductase