[Clinical and laboratory comparisons of tetracycline penetration through the blood-cerebrospinal fluid barrier in central nervous system diseases].
The data on tetracycline penetration from the blood into the serebrospinal fluid of patients with different diseases of the central nervous system are presented. Clinico-laboratory comparisons showed that the antibiotic penetration did not depend on the character and severity of the main disease of the brain (tumor, trauma, abscess). No dependence on the surgical intervention was either found. The index of tetracycline penetration from the blood into the liquor did not depend on the drug administration route, i.e. intramuscularly or orally. The presence of the post-operative meningitis increased permeability of the brain membranes for tetracycline.
D000284:Administration, Oral; D001702:Biopharmaceutics; D001812:Blood-Brain Barrier / Q000187:drug effects*; D002493:Central Nervous System Diseases / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D006801:Humans; D007273:Injections, Intramuscular; D013752:Tetracycline / Q000378:metabolism / Q000627:therapeutic use*; D013997:Time Factors
D013752:Tetracycline
Kliniko-laboratornye sopostavleniia proniknoveniia tetratsiklina cherez gematolikvornyĭ bar'er u bol'nykh s zabolevaniiami tsentral'noĭ nervnoĭ sistemy.