title: Polio, politics, publicity, and duplicity: ethical aspects in the development of the Salk vaccine.
abstract: This paper is an historical account of the discovery, testing, and early distribution of the Salk polio vaccine. The discovery posed fundamental dilemmas of medical research, pharmaceutical production, and public health. This paper assesses the ethical problems which arose, and examines critically their resolution. The National Foundation for Infantile Paralysis (March of Dimes) financed and directed the discovery of the vaccine, subsequent field trials, and early distribution. The Foundation's role is analyzed with special attention to the conflicts between its philanthropic and scientific functions. The reat public demand which the discovery of the vaccine generated created a need for federal control which was only partly met. The federal government did not have sufficient institutional and legal mechanisms to assure the safety of the vaccine and protect the public. This discussion illustrates the failure of the government to keep pace with medical technology.
mesh_terms: D002648:Child; D004341:Drug Evaluation / Q000379:methods; D035082:Federal Government; D033161:Government Regulation; D049673:History, 20th Century; D006805:Human Experimentation; D006801:Humans; D011054:Poliovirus Vaccine, Inactivated / Q000266:history*; D011057:Politics; D014481:United States
chemical_list: D011054:Poliovirus Vaccine, Inactivated