[Comparative studies of the response of normolipemic and dyslipemic aged subjects to 2 forms of delayed-action nicotinic acid polyesters. Pentaerythrotol tetranicotinate and inositol hexanicotinate. Results of a controlled cross-over trial].
A cross-over trial was run to compare the effects of two delayed-action nicotinic acid polyesters (pentaerythritol-tetranticotinate, PETN, and inositol-hexanicotinate, MIEN) in 59 aged normo- and dyslipaemic subjects. PETN tended to normalise the lipid picture in much the same way as nicotin acid, without a drastic effect on circulating lipids and lipoproteins. MIEN, on the other hand, had only a slight effect on total blood lipids, and appeared to be ineffective or negative with respect to the other lipid parameters. PETN proved capable of releasing active concentrations of nicotinic acid in vivo for a period of time that was sufficient to correct hyperlipaemia in age subjects. The side-effects were slight, infrequent and quickly reversible.
D000367:Age Factors; D000368:Aged; D002784:Cholesterol / Q000097:blood; D002986:Clinical Trials as Topic; D003692:Delayed-Action Preparations; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000188:drug therapy*; D007294:Inositol / Q000009:adverse effects / Q000627:therapeutic use*; D008074:Lipoproteins / Q000097:blood; D008099:Liver / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009531:Niceritrol / Q000009:adverse effects / Q000627:therapeutic use*; D009539:Nicotinic Acids / Q000009:adverse effects / Q000627:therapeutic use*; D010743:Phospholipids / Q000097:blood; D014280:Triglycerides / Q000097:blood
D003692:Delayed-Action Preparations; D008074:Lipoproteins; D009539:Nicotinic Acids; D010743:Phospholipids; D014280:Triglycerides; D007294:Inositol; D002784:Cholesterol; D009531:Niceritrol
Ricerche comparative in anziani normolipemici e dislipemici con due forme di acido nicotinico latenziato come poliestere. Pentaeritritolo-tetranicotinato e inositolo-esanicotinato. Risultati di una sperimentazione controllata in cross-over.