title: Rena transplantation and HLA-A, B matching. Theoretical considerations concerning pool size.
abstract: The rate of improvement in HLA-matching quality with increasing pool size is predicted. The frequency of HLA-A, B compatible matches increases rapidly up to approximately 47% for pool size 1000 and from then on the increase is more moderate while for HLA-A, B fullhouse-identical matches the increase in frequency is slower and more constant, the expected frequency being approximately 33% at a pool size of 2500. The import/export balance between two cooperating pools is estimated for various relative pool sizes and transplantation activities.
mesh_terms: D005787:Gene Frequency; D006680:HLA Antigens; D006650:Histocompatibility Testing; D006801:Humans; D016030:Kidney Transplantation; D008954:Models, Biological; D013223:Statistics as Topic; D014184:Transplantation, Homologous
chemical_list: D006680:HLA Antigens