A clinical comparison of 99mTc-diethyl-iminodiacetic acid, 99mTc-pyridoxylideneglutamate, and 131I-rose bengal in liver transplant patients.
The relative merits of three radiopharmaceuticals for evaluating liver transplant patients were determined in paired studies. In 86% of studies both 131I-RB and 99mTc-PG gave similar information for differentiation of hepatocellular disease and billary tract obstruction. 99mTc-PG probably demonstrates the biliary tract and small intestine better early after injection (8%); 131I-RB is probably better in showing the colon at 24 hours when intestinal activity is not seen by 1 hour (6%). 99mTc-diethyl-IDA is superior in all respects when compared to 99mTc-PG. The blood retention method (20 min./5 min.) showed that none of the radiopharmaceuticals was a reliable indicator of hepatocyte function when compared to total serum bilirubin.
D001660:Biliary Tract Diseases / Q000000981:diagnostic imaging; D003106:Colon / Q000000981:diagnostic imaging; D003998:Dicarboxylic Acids / Q000138:chemical synthesis; D004341:Drug Evaluation; D005971:Glutamates / Q000138:chemical synthesis; D006801:Humans; D007098:Imino Acids / Q000138:chemical synthesis; D007421:Intestine, Small / Q000000981:diagnostic imaging; D007457:Iodine Radioisotopes; D007553:Isotope Labeling; D008107:Liver Diseases / Q000000981:diagnostic imaging; D008111:Liver Function Tests / Q000379:methods*; D016031:Liver Transplantation; D008722:Methods; D011730:Pyridoxal / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D011877:Radionuclide Imaging; D012395:Rose Bengal; D013667:Technetium; D013997:Time Factors; D014184:Transplantation, Homologous
D003998:Dicarboxylic Acids; D005971:Glutamates; D007098:Imino Acids; D007457:Iodine Radioisotopes; D012395:Rose Bengal; D011730:Pyridoxal; D013667:Technetium