title: Plaque-inhibiting effect of dentifrices containing stannous fluoride.
abstract: The present study showed that the plaque inhibiting effect of aqueous solutions of stannous fluoride can be maintained in toothpastes. A commercial toothpaste containing 0.4 per cent of water soluble tin was effective whereas one containing 0.03 per cent showed no effect. The plaque inhibiting effect was shown in one study where the toothpastes were applied in cap splints and the plaque was scored after four days by the Plaque Index of Löe, and in another where the effect of locally applied pastes was monitored 24 hours later by the Gingival margin Plaque Index of Harrap. The present investigation supports the view that the stannous ion is essential in the plaque inhibition caused by stannous fluoride preparation. The exact mechanism is unknown but it is speculated that a change in the surface potential of oral bacteria through interaction with the stannous ion may be important.
mesh_terms: D002710:Chlorhexidine / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003773:Dental Plaque / Q000517:prevention & control*; D003802:Dentifrices / Q000032:analysis / Q000627:therapeutic use*; D004311:Double-Blind Method; D004341:Drug Evaluation; D005260:Female; D005459:Fluorides / Q000627:therapeutic use*; D006801:Humans; D010710:Phosphates / Q000627:therapeutic use; D010919:Placebos; D014001:Tin / Q000032:analysis; D014002:Tin Fluorides / Q000627:therapeutic use*; D014003:Tin Polyphosphates / Q000627:therapeutic use
chemical_list: D003802:Dentifrices; D010710:Phosphates; D010919:Placebos; D014002:Tin Fluorides; D014003:Tin Polyphosphates; D014001:Tin; D005459:Fluorides; D002710:Chlorhexidine