title: [Influence of (+)-cyanidanol-3 on acute hepatitis. Results of a double blind study (author's transl)].
abstract: 42 cases of acute hepatitis diagnosed from 1970 to 1974 were reviewed retrospectively. The effect of (+)-Cyanidanol-3 on the course of acute hepatitis was controlled on 35 patients in a double blind study. During acute hepatitis, bed rest had an essential influence on the time needed to normalize the transaminases. Based on these observations, we proved the effect, that during treatment with (+)-Cyanidanol-3 the patients showed a positive influence regarding the time for normalization of the transaminases in contrast to the placebo-group. During the first weeks the depression of the transaminase-activity in the blood was noticeable. Because of the small number of patients in that group, this effect could not yet been proved statistically. The stimulation of ATP synthesis as the main therapeutic principle can show a favourable result in the treatment of acute hepatitis.
mesh_terms: D000208:Acute Disease; D000328:Adult; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005419:Flavonoids / Q000627:therapeutic use*; D006505:Hepatitis / Q000188:drug therapy*; D006801:Humans; D008099:Liver / Q000201:enzymology; D010919:Placebos; D012189:Retrospective Studies; D013268:Stimulation, Chemical; D000637:Transaminases / Q000378:metabolism
chemical_list: D005419:Flavonoids; D010919:Placebos; D000637:Transaminases
vernacular_title: Einfluss von (+)-Cyanidanol-3 auf den Verlauf der akuten Hepatitis. Ergebnisse einer Doppelblindstudie.