title: Studies on the effect of parenteral iron, Ferastral, an iron-poly(sorbitol-gluconic acid) complex, on blood coagulation in man.
abstract: The possible influence of Ferastral, an iron-poly(sorbitol-gluconic acid) complex, on blood coagulation in man was investigated. Ferastral added to plasma produced no changes in blood coagulation until a final concentration of 2 000 microgram/ml (35.8 mmol/1) was used, when minimal changes in blood coagulation factors were observed. Five patients were given an intramuscular injection of 250 mg Ferastral. No changes in blood coagulation and thrombocyte function were observed up to 5 hours after the initial iron injection.
mesh_terms: D000328:Adult; D000368:Aged; D001777:Blood Coagulation / Q000187:drug effects*; D001792:Blood Platelets / Q000187:drug effects; D002986:Clinical Trials as Topic; D004338:Drug Combinations; D005260:Female; D005942:Gluconates / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D007273:Injections, Intramuscular; D007501:Iron / Q000008:administration & dosage* / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D013012:Sorbitol / Q000494:pharmacology
chemical_list: D004338:Drug Combinations; D005942:Gluconates; D013012:Sorbitol; D007501:Iron