A study of the effects of gonadotropin-releasing hormone on human mood and behavior.
Gonadotropin-releasing hormone in doses up to 500 microgram was administered to 12 healthy male volunteers. Luteinizing hormone and testosterone levels increased subsequent to GnRH administration. No immediate effects of GnRH on mood and behavior were noted, though an increase in alertness, a decrease in anxiety and fatigue, and an increased speed of performance on automatized motor tasks were noted several hours after GnRH administration.
D000328:Adult; D001007:Anxiety / Q000188:drug therapy; D001288:Attention / Q000187:drug effects; D001519:Behavior / Q000187:drug effects*; D004644:Emotions / Q000187:drug effects*; D005221:Fatigue / Q000188:drug therapy; D006801:Humans; D007263:Infusions, Parenteral; D007275:Injections, Intravenous; D007989:Libido / Q000187:drug effects; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009048:Motor Skills / Q000187:drug effects; D010906:Pituitary Hormone-Releasing Hormones / Q000008:administration & dosage / Q000494:pharmacology*; D013739:Testosterone / Q000097:blood; D013997:Time Factors
D010906:Pituitary Hormone-Releasing Hormones; D013739:Testosterone; D007986:Luteinizing Hormone