Surface membrane characteristics of cells from human acute monocytic leukaemia.
The clinical and laboratory features of 4 patients with acute monocytic leukaemia are described. Surface membrane receptor studies of these patients have shown increasing strength of receptor expression occurs with increasing morphological maturity of the monocyte. In addition, the study shows that expression of membrane receptors can vary from patient to patient and also with time and treatment in an individual patient. A further finding has been the loss of positivity with specific anti-monocyte serum when the disease becomes refractory to therapy.
D000328:Adult; D001666:Binding Sites, Antibody; D002462:Cell Membrane / Q000276:immunology*; D002478:Cells, Cultured; D003176:Complement C3; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007141:Immunoglobulin Fc Fragments; D007075:Immunoglobulin M; D007948:Leukemia, Monocytic, Acute / Q000276:immunology*; D007962:Leukocytes / Q000276:immunology*; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology; D012397:Rosette Formation
D003176:Complement C3; D007141:Immunoglobulin Fc Fragments; D007075:Immunoglobulin M