Effect of systemic lupus erythematosus antibodies against DNA on RNA synthesis.
The majority of tested systemic lupus erythematosus (SLE) sera inhibited RNA synthesis in vitro on the stage of RNA chain elongation. Two sera were also active in inhibiting the binding of the enzyme to the template. No correlation has been found between the sera activity in filter radioimmunoassay, their specificity to double- or single-stranded DNA, and the degree of RNA synthesis inhibition.
D000906:Antibodies; D004247:DNA / Q000276:immunology*; D004269:DNA, Bacterial / Q000276:immunology; D012321:DNA-Directed RNA Polymerases; D004926:Escherichia coli / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D012313:RNA / Q000096:biosynthesis* / Q000276:immunology; D012260:Ribonucleases / Q000378:metabolism
D000906:Antibodies; D004269:DNA, Bacterial; D007136:Immunoglobulins; D012313:RNA; D004247:DNA; D012321:DNA-Directed RNA Polymerases; D012260:Ribonucleases