Procoagulant activity of activated monocytes.
Endotoxin-stimulated monocytes develop a very high tissue-factor-like activity as compared to an equivalent number of monocytes in a preparation of monocyte-enriched mononuclear blood cells obtained by Ficoll-Urovision density gradient centrifugation which is not exposed to endotoxin. In monocytes which were obtained by plastic adherence from the monocyte-enriched mononuclear blood cells, the tissue factor activity was as high as in the endotoxin-stimulated monocytes.
D001427:Bacterial Toxins / Q000494:pharmacology; D002448:Cell Adhesion; D002469:Cell Separation / Q000379:methods; D002499:Centrifugation, Density Gradient; D006801:Humans; D009000:Monocytes / Q000378:metabolism*; D012477:Salmonella enteritidis; D013925:Thromboplastin / Q000378:metabolism*
D001427:Bacterial Toxins; D013925:Thromboplastin