Diversity of the anti-HBc response and its correlations with other immunological parameters in asymptomatic HBsAg carriers.
The anti-HBc response was investigated by immunofluorescence in the sera of 109 asymptomatic HBsAg carriers. The results suggest the presence of at least two antigenic HBcAg determinants, possibly correlated with the replication phase. The subjects with intensive anti-HBc response showed immunological alterations consistent with the presence of active liver lesions and of hepatocellular membrane injury.
D000914:Antibodies, Viral / Q000032:analysis*; D002353:Carrier State / Q000276:immunology; D002467:Cell Nucleus / Q000276:immunology; D005455:Fluorescent Antibody Technique; D006509:Hepatitis B / Q000276:immunology; D006510:Hepatitis B Antibodies / Q000032:analysis*; D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens; D006801:Humans; D008099:Liver / Q000276:immunology* / Q000648:ultrastructure
D000914:Antibodies, Viral; D006510:Hepatitis B Antibodies; D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens