title: Biphasic saturations of binding proteins can be the result of a competitive inhibition of substrate fixation.
abstract: A mathematical model is proposed which explains some biphasic saturations of Binding Proteins by their substrates through an effect of a competitive inhibition. The inhibitor can be the substrate itself especially when the retention phenomenon is occuring. This model has been verified with two periplasmic Binding Proteins of Escherichia coli: the Glutamine Binding Protein and the Leucine-Isoleucine-Valine Binding Protein. A significant connection is found between experimental results and the hypothesis.
mesh_terms: D001667:Binding, Competitive; D002352:Carrier Proteins / Q000378:metabolism; D004926:Escherichia coli / Q000378:metabolism; D005973:Glutamine; D007700:Kinetics; D008433:Mathematics; D008956:Models, Chemical; D009842:Oligopeptides; D011485:Protein Binding
chemical_list: D002352:Carrier Proteins; D009842:Oligopeptides; D005973:Glutamine