Prevention of skin flap necrosis by a course of treatment with vasodilator drugs.
Large island skin flaps, comprising the entire abdominal covering in rats, were raised on one neurovascular pedicle in the groin. A standard area of necrosis was produced on the other side from the pedicle. However, when the animals were treated with certain vasodilator drugs for 15 days before and 7 days after the flaps were raised, there was little or no necrosis. The effect of the drug therapy was the same as a surgical delay.
D000818:Animals; D006145:Guanethidine / Q000494:pharmacology*; D006830:Hydralazine / Q000494:pharmacology*; D007556:Isoxsuprine / Q000494:pharmacology*; D009336:Necrosis; D010643:Phenoxybenzamine / Q000494:pharmacology*; D051381:Rats; D012867:Skin / Q000187:drug effects / Q000473:pathology; D016038:Skin Transplantation; D014182:Transplantation, Autologous; D014664:Vasodilation
D010643:Phenoxybenzamine; D006830:Hydralazine; D007556:Isoxsuprine; D006145:Guanethidine