[Treatment of Sydenham's chorea with perphenazine].
Symptomatic therapy in Sydenham's chorea has not been satisfactory. Perphenazine was tested as an alternative to diminish abnormal movements. A Syndenham's chorea comparative double-blind study (17 patients) using it, with reserpine and placebo as controls, was designed. Perphenazine was tried also in another open-study (13 patients with Syndenham's chorea). Out of the 2 groups, those which received perphenazine improved earlier and in a greater proportion than controls, with statistical significance (p is less than 0.01).
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002819:Chorea / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D010546:Perphenazine / Q000627:therapeutic use*; D010919:Placebos; D012110:Reserpine / Q000627:therapeutic use; D012213:Rheumatic Fever / Q000150:complications
D010919:Placebos; D012110:Reserpine; D010546:Perphenazine
Tratamiento de la corea de Sydenham con perfenazina.