title: Murein biosynthesis during a synchromous cell cycle of Escherichia coli B.
abstract: The last stages of murein biosynthesis were studied in relation to the division cycle of Escherichia coli in cells synchronized by amino acid starvation (Ron et al., J. Bacteriol. 123:374--376, 1975). Murein synthesis and the activities of the D-alanine carboxypeptidase and transpeptidase were found to vary significantly during the cell cycle. Maximal synthesis and transpeptidation were observed immediately after cell division, whereas maximal D-alanine carboxypeptidase activity was detected before cell division. These results are in agreement with our earlier findings that before cell division there is a stage of increased hydrolysis of the C-terminal D-alanine moiety of newly synthesized murein strands.
mesh_terms: D002268:Carboxypeptidases / Q000378:metabolism; D002455:Cell Division; D004926:Escherichia coli / Q000254:growth & development / Q000378:metabolism*; D010457:Peptidoglycan / Q000096:biosynthesis*; D010458:Peptidyl Transferases / Q000378:metabolism
chemical_list: D010457:Peptidoglycan; D010458:Peptidyl Transferases; D002268:Carboxypeptidases