[Essential hypertension: long term haemodynamic effects of a diuretic combination (cyclothiazide-triamterene) (author's transl)].
The long terme hemodynamic effect of cyclothiazide 3 mg-triamterene 150 mg was studied in 10 patients with permanent essential hypertension. Diuretic therapy induced a significant fall in blood pressure (p less than 0.001) and total peripheral resistance (p less than 0.01), without significant change in cardiac index or blood volume. The result suggests that adaptative mechanisms of the circulatory system determine the decrease of blood pressure, independently of the pharmacological effect of the drug.
D000328:Adult; D001581:Benzothiadiazines; D001794:Blood Pressure / Q000187:drug effects; D001810:Blood Volume / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D002986:Clinical Trials as Topic; D004232:Diuretics; D004359:Drug Therapy, Combination; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008875:Middle Aged; D049993:Sodium Chloride Symporter Inhibitors / Q000494:pharmacology*; D014223:Triamterene / Q000494:pharmacology*; D014655:Vascular Resistance / Q000187:drug effects
D001581:Benzothiadiazines; D004232:Diuretics; D049993:Sodium Chloride Symporter Inhibitors; D014223:Triamterene
Hypertension artérielle essentielle: effet hémodynamique à long terme d'une association diurétique (cyclothiazide-triamtérène).