Further studies on the restoration of estrogen-induced sexual receptivity in ovariectomized mice treated with dihydrotestosterone: effects of progesterone, dihydroprogesterone and LH-RH.
Sexual receptivity in ovariectomized CD-1 mice induced by chronic daily injections of estradiol benzoate (E2B) was inhibited in a dose related fashion by daily injections of dihydrotestosterone (DHT) given concurrently with the E2B. Administration of the progestins, progesterone and dihydroprogesterone (DHP), and of the hypothalamic decapeptide, LH-RH, 6 hr prior to testing restored receptivity to varying degrees in these E2B + DHT treated mice. Of these treatments progesterone was clearly the most effective, followed by LH-RH and finally DHP in restoring estrogen-induced receptivity. Results were discussed in terms of a proposed essential role for LH-RH in the induction of sexual receptivity in mice.
D004092:20-alpha-Dihydroprogesterone / Q000494:pharmacology*; D000818:Animals; D002369:Castration; D013196:Dihydrotestosterone / Q000494:pharmacology*; D004347:Drug Interactions; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology*; D051379:Mice; D011374:Progesterone / Q000031:analogs & derivatives* / Q000494:pharmacology*; D012726:Sexual Behavior, Animal / Q000187:drug effects*
D013196:Dihydrotestosterone; D004092:20-alpha-Dihydroprogesterone; D007987:Gonadotropin-Releasing Hormone; D011374:Progesterone; D004958:Estradiol