Screening for the mutagenicity of nitro-group containing hypoxic cell radiosensitizers using Salmonella typhimurium strains TA 100 and TA98.
A series of sixteen 2-, 4- and 5-nitroimidazoles, four nitrobenzenes, five nitrofurans, and a nitropyrrole, most of which have been studied previously as hypoxic cell specific radiosensitizers, have been screened for their mutagenicity using the Salmonella typhimurium strains TA 100 and TA 98 developed by Ames and co-workers. Most of these compounds were mutagenic and had a one to two order of magnitude greater mutagenicity towards TA 100 (base-pair substitution sensitive) than TA 98 (frame-shift sensitive). The spectrum of mutagenic efficiencies for the drugs which was observed could be correlated to some extent with the electron affinity of these compounds. Exceptions to this correlation may indicate drugs of interest for further studies both as mutagens and hypoxic cell radiosensitizers.
D004353:Drug Evaluation, Preclinical; D005821:Genetic Techniques; D009153:Mutagens; D009574:Nitro Compounds / Q000494:pharmacology*; D009578:Nitrobenzenes / Q000494:pharmacology; D009581:Nitrofurans / Q000494:pharmacology; D009593:Nitroimidazoles / Q000494:pharmacology; D011758:Pyrroles / Q000494:pharmacology; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000187:drug effects
D009153:Mutagens; D009574:Nitro Compounds; D009578:Nitrobenzenes; D009581:Nitrofurans; D009593:Nitroimidazoles; D011758:Pyrroles; D011838:Radiation-Sensitizing Agents