Premalignant and malignant uterine changes in immunosuppressed renal transplant recipients.
29 female immunosuppressed renal transplant recipients were examined gynecologically. In 2 cases the epithelium of the portio was found to be dysplastic, while endometrial carcinoma was present in 1 patient. A review of the literature suggests that immunosuppressed patients are more likely to develop tumors than others. The authors stress the need for gynecological and cytological examinations at short intervals, to identify premalignant and early malignant uterine changes at a time at which these can readily be treated without discontinuation of the immunosuppressive therapy.
D000230:Adenocarcinoma / Q000276:immunology*; D000328:Adult; D002584:Cervix Uteri / Q000473:pathology; D004717:Endometrium / Q000473:pathology; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D016030:Kidney Transplantation; D014184:Transplantation, Homologous; D002578:Uterine Cervical Dysplasia / Q000276:immunology* / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000276:immunology*; D014594:Uterine Neoplasms / Q000276:immunology* / Q000473:pathology