[Experimental studies on the therapeutic modification of intestinal adhesion formation].
One of the main problems encountered by the surgeon are visceral adhesions after abdominal surgery. This problem was studied in animal experiments by inducing peritoneal adhesions in 30 albino rats. The anti-inflammatory, resp. anti-adhesive effect of corticosteroids and antihistamines was tested by application of these drugs before, resp. after surgery. Anti-inflammatory proteolytic enzymes (Wobe-Mugos) were applied pre-, resp. postoperatively in two other groups. A fifth group served as controls. A modified cotton-pellet technique was used for the experiments. The best results were achieved when "Wobe-Mugos" was applied after surgery.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D002744:Chlorpheniramine / Q000008:administration & dosage; D002986:Clinical Trials as Topic; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage; D010447:Peptide Hydrolases / Q000008:administration & dosage*; D010537:Peritoneum; D011182:Postoperative Care; D011300:Preoperative Care; D051381:Rats; D000267:Tissue Adhesions / Q000517:prevention & control*
D000893:Anti-Inflammatory Agents; D002744:Chlorpheniramine; D010447:Peptide Hydrolases; D008775:Methylprednisolone
Experimentelle Untersuchungen zur therapeutischen Beeinflussbarkeit intestinaler Adhäsionsvorgänge.