Salicylate sensitivity in children reported to respond to salicylate exclusion.
Twelve children, aged six to 13 years, whose parents reported an improvement in behavioural problems with use of the Feingold (K-P) diet for an average period of 12 months, were challenge-tested with 40 mg of acetylsalicylic acid in a double-blind, cross-over trial with ascorbic acid as a placebo. The children were tested within three hours of ingestion of either the experimental or placebo tablet with a battery of psychological and neurological tests, and were rated by a parent on an enlarged Conners' Parent-Teacher Questionnaire for four days after the ingestion of the tablet. It was found that significance was reached in tests of general cognitive capacity, line walking and the "finger-to-nose" tests, as well as increased disturbance in sleep patterns in these children.
D000293:Adolescent; D000485:Allergens / Q000008:administration & dosage; D001205:Ascorbic Acid; D001241:Aspirin / Q000008:administration & dosage / Q000009:adverse effects*; D002648:Child; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004342:Drug Hypersensitivity / Q000178:diet therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006948:Hyperkinesis / Q000139:chemically induced* / Q000178:diet therapy; D008297:Male; D010919:Placebos; D011795:Surveys and Questionnaires
D000485:Allergens; D010919:Placebos; D001205:Ascorbic Acid; D001241:Aspirin