Gastrin cell populations after highly selective vagotomy in the dog.
Highly selective vagotomy was performed on five dogs. Postoperatively, gastrin cell (G cell) hyperplasia occurred in all dogs. Mean preoperative G cell numbers increased from 350 to 530/cm mucosal length (p less than 0.02). Antral tissue gastrin also increased by 100 per cent (6.7 x 10(6) to 13.7 x 10(6) pg/gm tissue, p less than 0.05). Basal and stimulated serum gastrin were unchanged following highly selective vagotomy. The cause for G cell hyperplasia is not clear, but is probably multifactorial.
D000818:Animals; D001706:Biopsy; D002452:Cell Count; D004285:Dogs; D005455:Fluorescent Antibody Technique; D005753:Gastric Mucosa / Q000166:cytology* / Q000294:innervation / Q000378:metabolism; D005755:Gastrins / Q000378:metabolism; D006965:Hyperplasia; D008722:Methods; D011706:Pyloric Antrum / Q000166:cytology* / Q000294:innervation / Q000378:metabolism; D014628:Vagotomy
D005755:Gastrins