Non-major histocompatibility system immunogenetic influences in rat renal allograft survival.
H-1-incompatible rat renal allograft survival rates are strongly influenced by the non-major histocompatibility system (MHS) genes. The same H-1 (MHS) incompatibility tested on four different non-MHS backgrounds gave widely differing results ranging from 11 to 60% fractional survival between the best and the poorest (P less than 0.01) at 105 days. These results can best be explained if non-H-1 and intra-MHS amplifiers and/or suppressors are invoked.
D000818:Animals; D006085:Graft Survival; D016027:Heart Transplantation; D006648:Histocompatibility; D016030:Kidney Transplantation; D008214:Lymphocytes; D051381:Rats; D011917:Rats, Inbred Lew; D011919:Rats, Inbred Strains; D016038:Skin Transplantation; D014184:Transplantation, Homologous