Amitriptyline- and mianserin-induced changes in acquisition of paired-association learning-task.
1 The double-blind study on twenty healthy students was an attempt at assessing the effects of 2-week's treatment with amitriptyline (25 mg three times a day) and mianserin (10 mg three times a day), each alone or separatively inbibed with alcohol (0.5 g/kg) on the immediate memory and on the acquisition of a paired-association learning-task. 2 Amitriptyline impaired both the short-term memory-span and acquisition, and alcohol potentiated these effects. The action of mianserin did not deviate significantly from that of the placebo, and it also failed to interact with alcohol. 3 It is concluded that the decrement in learning capacity, that occurs after the 2-week's treatment with therapeutic doses of amitriptyline, reflects changes in both the intrinsic and the regulatory mechanisms of learning.
D000328:Adult; D000639:Amitriptyline / Q000097:blood / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D003984:Dibenzazepines / Q000494:pharmacology*; D004311:Double-Blind Method; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology; D005260:Female; D005425:Flicker Fusion / Q000187:drug effects; D006801:Humans; D006993:Hypnotics and Sedatives; D007700:Kinetics; D007858:Learning / Q000187:drug effects*; D008297:Male; D008570:Memory, Short-Term / Q000187:drug effects; D008803:Mianserin / Q000494:pharmacology*
D003984:Dibenzazepines; D006993:Hypnotics and Sedatives; D000639:Amitriptyline; D008803:Mianserin; D000431:Ethanol