title: Isolation and partial characterization of an antibody enhancing factor from leukaemic owl monkey cell cultures.
abstract: Herpesvirus saimiri inoculated into owl monkeys (Aotus trivirgatus) causes leukaemia and lymphoma. Peripheral lymphocytes from leukaemic monkeys grown in culture are predominantly T lymphocytes. The supernatants from these cultures  contain a factor which enhances the antibody response of murine B cells to sheep red blood cells (SRBC). The factor has been partially characterized by ammonium sulphate precipitation, DEAE-chromatography, gel filtration over Sephadex G-150 and disc-gel electrophoresis. The enhancing factor is a protein with a molecular weight of approximately 40,000.
mesh_terms: D000818:Animals; D000917:Antibody Formation; D001029:Aotus trivirgatus; D002457:Cell Extracts / Q000032:analysis; D002478:Cells, Cultured; D006462:Hemolytic Plaque Technique; D007942:Leukemia, Experimental / Q000276:immunology*; D008211:Lymphocyte Cooperation; D008934:Mitogens; D008970:Molecular Weight; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D002457:Cell Extracts; D008934:Mitogens