Enchancement of nitrosoguanidine mutagenesis by chloramphenicol in Escherichia coli K-12.
N-methyl-N'-nitro-N-nitrosoguanidine-induced mutagenesis in E. coli K-12 can be enchanced up to 50-fold by the addition of chloramphenicol with minimal effect on survival. Chloramphenicol does not produce the expected proportionate increase in closely linked double mutations.
D002701:Chloramphenicol / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics*; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology*; D009154:Mutation / Q000187:drug effects*; D012293:Rifampin / Q000494:pharmacology
D008769:Methylnitronitrosoguanidine; D002701:Chloramphenicol; D012293:Rifampin