title: [Effect of terrilytin on antifungal antibiotic activity].
abstract: The antifungal activity of terrilitine, an enzymatic preparation of microbial origin and its effect on the activity of antifungal polyenic antibiotics and griseofulvine were studied in vitro. It was found with the method of serial dilutions in Sabourand's liquid medium that terrilitine was active against C. albicans and certain dermatophytes. In combination with amphotericin B, amphoglucamine, mycoheptine, levorin, nystatin or griseofulvin it increased the activity of these antibiotics 2-16 times.
mesh_terms: D000681:Amylases / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D001230:Aspergillus / Q000201:enzymology*; D002176:Candida albicans / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004347:Drug Interactions; D006118:Griseofulvin / Q000494:pharmacology; D010447:Peptide Hydrolases / Q000494:pharmacology*; D014249:Trichophyton / Q000187:drug effects
chemical_list: D000935:Antifungal Agents; D004338:Drug Combinations; D006118:Griseofulvin; C009402:amylase, phosphates, proteases drug combinations; D000681:Amylases; D010447:Peptide Hydrolases
vernacular_title: Vliianie terrilitina na aktivnost' protivogribkovykh antibiotikov.