Sister-chromatid exchange induced by X-ray of human lymphocytes and the effect of L-cysteine.
A staining technique that detects sister-chromatid exchanges (SCEs) has been used to examine the response of human lymphocyte chromosomes to various dosages of X-irradiation. The SCE frequency was markedly increased following irradiation. However, the increase was of a significantly smaller magnitude when irradiation occurred in the presence of an antimutagenic agent. Scoring SCEs may provide a useful technique for assaying the mutagenic effects of environmental carcinogens as well as the protective effects of antimutagenic agents.
D002875:Chromosomes / Q000528:radiation effects*; D003434:Crossing Over, Genetic / Q000187:drug effects*; D003545:Cysteine / Q000494:pharmacology*; D003584:Cytological Techniques; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008214:Lymphocytes / Q000528:radiation effects / Q000648:ultrastructure; D011837:Radiation-Protective Agents; D014965:X-Rays
D011837:Radiation-Protective Agents; D003545:Cysteine