Bacteriophage conversion of heat-labile enterotoxin in Escherichia coli.
A temperate phage designated obeta1 (omicron beta) was mitomycin C induced and isolated from heat-labile enterotoxin (LT)-producing Escherichia coli E2631-C2. Phage obeta1 infected the nonlysogenic, nontoxigenic, mitomycin C-sensitive strain of E. coli K-12 (CSH38) and converted it to lysogeny and enterotoxigenicity. After the establishment of lysogeny, E. coli CSH38(obeta1) produced produced LT and phage particles at maximal levels following mitomycin C induction. The LT Tox+ character is carried by the temperate phage obeta1.
D003090:Coliphages / Q000235:genetics*; D004768:Enterotoxins / Q000096:biosynthesis*; D004926:Escherichia coli / Q000235:genetics* / Q000378:metabolism; D006358:Hot Temperature; D008242:Lysogeny; D008937:Mitomycins / Q000494:pharmacology; D013268:Stimulation, Chemical
D004768:Enterotoxins; D008937:Mitomycins