title: Theoretical and practical considerations on the problem of metal--metal interaction.
abstract: The interaction between two metals, which can be either synergistic or antagonistic, implies that the behavior of one is changed by the presence of the other. Possible mechanisms of these interactions, which include chemical association, competition for carriers, metabolic changes, induction of binding proteins, membrane alterations are discussed.
mesh_terms: D000818:Animals; D001665:Binding Sites / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D004347:Drug Interactions; D008670:Metals / Q000378:metabolism / Q000494:pharmacology*; D010084:Oxidation-Reduction; D011485:Protein Binding / Q000187:drug effects; D013347:Subcellular Fractions / Q000502:physiology / Q000648:ultrastructure
chemical_list: D008670:Metals