Urologic complications in renal transplantation.
The current overall reported incidence of major urologic complications following renal transplantation is 5 per cent. The presence of such a complication increases the likelihood of patient mortality by a factor of three. Standard utilization of postoperative radionuclide scanning is very useful in early diagnosis. Vesical fistulas generally result from improper bladder closure. The incidence of bladder complications increases with secondary and tertiary grafts. Ureteral complications result when the blood supply of the ureter is impaired. These include fistula formation, necrosis, and obstruction. Immediate surgical correction is indicated in almost all serious urologic complications following transplantation; otherwise there is marked increase in morbidity and mortality. Complications appearing early in the postoperative period carry a poor prognosis for both graft and recipient survival. The presence of urinary tract infection early in the postoperative period also correlates negatively with graft survival. The presence of multiple renal arteries in the donor has been associated with an increased rate of urologic complications. Ureteral fistulas can be avoided by meticulous dissection of the donor at the time or organ harvesting. Great care must be taken to preserve the arterial and venous blood supply to the ureter by avoiding any dissection into the renal hilum. Aberrant renal arteries must be preserved or repaired if damaged. Ureteroneocystostomy is the preferred method for re-establishing urinary tract continuity following transplantation. The immediate surgical correction of urologic complications is mandatory, and the techniques involved are highly specialized and must be individualized with each patient.
D007172:Erectile Dysfunction / Q000209:etiology; D005260:Female; D005402:Fistula / Q000209:etiology / Q000628:therapy; D006801:Humans; D007670:Kidney Calices; D007674:Kidney Diseases / Q000209:etiology; D016030:Kidney Transplantation; D008196:Lymph / Q000378:metabolism; D008297:Male; D011183:Postoperative Complications / Q000628:therapy; D012422:Rupture, Spontaneous; D012871:Skin Diseases / Q000209:etiology / Q000628:therapy; D013997:Time Factors; D014184:Transplantation, Homologous; D014515:Ureteral Diseases / Q000209:etiology / Q000628:therapy; D001747:Urinary Bladder Fistula / Q000209:etiology / Q000628:therapy; D014548:Urinary Fistula / Q000209:etiology / Q000628:therapy; D014552:Urinary Tract Infections / Q000209:etiology; D014565:Urogenital Neoplasms / Q000209:etiology; D014570:Urologic Diseases / Q000209:etiology*