A mechanobullous disease of the newborn. Bart's syndrome.
A patient had a unique mechanobullous disease (Bart's syndrome). The characteristic congenital localized skin defects, trauma-induced erosions, and nail deformities are present. The inheritance pattern appears to be autosomal dominant but, as in this report, isolated cases have been recognized. In a review of the other mechanobullous diseases, Bart's syndrome appears to present a distinctive clinical picture and course and has a favorable prognosis. The progressive spontaneous improvement emphasizes the importance of early recognition and conservative treatment.
D000015:Abnormalities, Multiple / Q000175:diagnosis; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009264:Nails, Malformed; D012868:Skin Abnormalities; D012872:Skin Diseases, Vesiculobullous / Q000175:diagnosis*; D013577:Syndrome