An unusual variant of membranous nephropathy with abundant crescent formation and recurrence in the transplanted kidney.
A patient with what initially appeared to be a typical membranous nephropathy had a progressive course to renal failure, nephrectomy, and transplantation. The nephrectomy specimen revealed abundant glomerular crescents and capsular synechiae. Post-transplantation the patient again developed a membranous nephropathy with florid crescents. Radioimmunoassay and indirect immunofluorescence tests failed to reveal anti-glomerular basement membrane antibody in the serum or kidney. It appears that there is a form of membranous nephropathy with crescent formation, unrelated to anti-GBM antibody, which has the capacity to recur after transplantation.
D000328:Adult; D001323:Autoantibodies / Q000032:analysis*; D001485:Basement Membrane / Q000276:immunology*; D002102:Cadaver; D003176:Complement C3 / Q000032:analysis; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007678:Kidney Glomerulus / Q000276:immunology / Q000473:pathology; D016030:Kidney Transplantation; D009404:Nephrotic Syndrome / Q000276:immunology / Q000473:pathology* / Q000601:surgery; D011183:Postoperative Complications / Q000473:pathology*; D012008:Recurrence; D014184:Transplantation, Homologous
D001323:Autoantibodies; D003176:Complement C3; D007074:Immunoglobulin G