The effect of doxapram on buprenorphine induced respiratory depression.
Doxapram administered as a single injection or infusion satisfactorily counteracted the respiratory depression produced by buprenorphrine when administered one hour after the analgesic in healthy subjects. The respiratory stimulant effect was relatively short lived, however, a more prolonged effect was found by study of the displacement of the carbon dioxide response curve.
D000328:Adult; D000700:Analgesics / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood; D002986:Clinical Trials as Topic; D004315:Doxapram / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D009019:Morphinans / Q000494:pharmacology*; D011680:Pupil / Q000187:drug effects; D012129:Respiratory Function Tests; D012131:Respiratory Insufficiency / Q000139:chemically induced / Q000188:drug therapy*
D000700:Analgesics; D009019:Morphinans; D002245:Carbon Dioxide; D004315:Doxapram