Effects of methylxanthine drugs on pyrogen-induced hyperthermia.
The hyperthermic response to pyrogen was not potentiated by caffeine or theophylline administered i.p. into cats or rabbit. Injection of these drugs into the anterior hypothalamus or into the third cerebral ventricle in cats was also without effect on pyrexia. These results support the hypothesis that cyclic AMP in the anterior hypothalamus does not mediate pyrogen-induced hyperthermia in cats.
D000818:Animals; D002110:Caffeine / Q000494:pharmacology; D005260:Female; D005334:Fever / Q000139:chemically induced / Q000503:physiopathology*; D008297:Male; D011749:Pyrogens / Q000494:pharmacology*; D011817:Rabbits; D012762:Shigella dysenteriae; D013806:Theophylline / Q000494:pharmacology; D013997:Time Factors; D014970:Xanthines / Q000494:pharmacology*
D011749:Pyrogens; D014970:Xanthines; D002110:Caffeine; D013806:Theophylline