Increased UV-inducibility of SOS functions in a dam-3 mutant of Escherichia coli K12 uvrA.
The dam-3 mutation caused a 2--4 fold increase in the susceptibility of E. coli K-12 uvrA to UV induction of prophage lambda, induced reactivation and mutagenesis of lambda, and mutation to histidine prototrophy. The increased inducibility exceeded the level expected by UV and dam-3 acting additively and independently, and suggests that the effects of UV and dam-3 interact in some way to potentiate induction of SOS functions.
D003090:Coliphages / Q000378:metabolism / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism / Q000528:radiation effects*; D005838:Genotype; D006639:Histidine / Q000378:metabolism; D008242:Lysogeny; D009154:Mutation; D013045:Species Specificity; D014466:Ultraviolet Rays
D006639:Histidine