title: Protein binding of drugs--the clinical significance.
abstract: Drug-protein binding is reviewed from a clinical and practical point of view. Commonly used drugs are discussed and the effects of disease, drug dosage and hypoalbuminaemia on drug-protein binding are reviewed. Doses of highly bound (greater than 80%) drugs in patients with hypoalbuminaemia, liver disease or renal failure should be regularly reviewed.
mesh_terms: D000305:Adrenal Cortex Hormones / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000925:Anticoagulants / Q000494:pharmacology; D006801:Humans; D007099:Imipramine / Q000494:pharmacology; D007668:Kidney / Q000502:physiology; D007674:Kidney Diseases / Q000503:physiopathology; D008099:Liver / Q000502:physiology; D008107:Liver Diseases / Q000503:physiopathology; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D010672:Phenytoin / Q000494:pharmacology; D011485:Protein Binding; D012709:Serum Albumin / Q000172:deficiency
chemical_list: D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents; D000925:Anticoagulants; D004364:Pharmaceutical Preparations; D012709:Serum Albumin; D010672:Phenytoin; D007099:Imipramine