Dissociation between ion permeability and the lethal action of polyene antibiotics on Candida albicans.
Kinetic data on potassium release from and killing of Candida albicans by the four polyene antibiotics amphotericin B, amphotericin B methyl ester hydrochloride, nystatin, and nystatin methyl ester hydrochloride are presented. The nystatins were relatively more effective than the amphotericins in causing potassium release rather than killing. These data suggest that the aqueous channels or pores formed by the polyene antibiotics are not central to the lethal action of the drugs.
D000666:Amphotericin B / Q000031:analogs & derivatives / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000378:metabolism; D007700:Kinetics; D009761:Nystatin / Q000031:analogs & derivatives / Q000494:pharmacology; D011090:Polyenes / Q000494:pharmacology; D011188:Potassium / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D011090:Polyenes; D009761:Nystatin; D000666:Amphotericin B; D011188:Potassium