title: The effect of 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide on acute viral hepatitis.
abstract: We studied the effect of 1-beta-ribofuranosyl-1,2,4-traizole-3-carboxamide (ribavirin) on 66 patients with acute viral hepatitis, by a double-blind study. Thirty-three of these patients received the active drug and the other 33 received a placebo. The effect of ribavirin was evaluated by the clinical picture and by the changes in both direct and total serum bilirubin and in the activity of serum glutamic-pyruvic and glutamic-oxaloacetic transaminases. There was a significant decrease in serum bilirubin, SGOT, and SGPT from the 5th to 10th day of treatment in the ribavirin group. In the placebo group such a decrease was observed but was not statistically significant.
mesh_terms: D000208:Acute Disease; D000328:Adult; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006525:Hepatitis, Viral, Human / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D008297:Male; D012254:Ribavirin / Q000627:therapeutic use*; D012263:Ribonucleosides / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D012263:Ribonucleosides; D012254:Ribavirin