Factors affecting the beta-cell sensitivity to alloxan in vivo. Influence of pre- and post-treatment with protective substances.
Blood glucose and pancreatic islet morphology were studied in mice subjected to different kinds of treatment both before and after alloxan administration. d-Glucose, d-mannose, d-fructose, NaHCO3 and sodium lactate protected against alloxan when given before, but not when given after alloxan, whereas l-leucine protected when administered before, and also when injected 1 or 3 min after alloxan. No protection was seen in animals receiving l-leucine 10 min following alloxan. The findings may indicate that the mechanism for alloxan protection by l-leucine differs from that of the other compounds tested.
D000496:Alloxan / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D000818:Animals; D001639:Bicarbonates / Q000494:pharmacology; D001786:Blood Glucose / Q000032:analysis; D005632:Fructose / Q000494:pharmacology; D005947:Glucose / Q000494:pharmacology; D007515:Islets of Langerhans / Q000187:drug effects* / Q000473:pathology; D007773:Lactates / Q000494:pharmacology; D007930:Leucine / Q000494:pharmacology; D008297:Male; D008358:Mannose / Q000494:pharmacology; D051379:Mice
D001639:Bicarbonates; D001786:Blood Glucose; D007773:Lactates; D005632:Fructose; D000496:Alloxan; D007930:Leucine; D005947:Glucose; D008358:Mannose