title: Effect of amino acid deprivation and chloramphenicol treatment on cell sizes of rel+ and relA- strains of Escherichia coli.
abstract: The effects of inhibition of protein synthesis on the cell size distributions of rel+ and relA- derivatives of Escherichia coli K-12 were determined. Amino acid deprivation resulted in a reduction in the cell sizes of rel+ strains but not of relA- strains. Treatment with chloramphenicol (CAM) did not alter the size distributions of either rel+ or relA- strains except when they were rel+ dap-. CAM treatment of rel+ dap- strains resulted in an increase in cell size. It is proposed that these results reflect differences in the structures of the cell envelopes of rel+ and relA- bacteria.
mesh_terms: D000596:Amino Acids / Q000378:metabolism*; D001426:Bacterial Proteins / Q000096:biosynthesis; D002701:Chloramphenicol / Q000494:pharmacology*; D004926:Escherichia coli / Q000166:cytology* / Q000235:genetics / Q000378:metabolism; D005796:Genes; D006150:Guanine Nucleotides / Q000235:genetics; D008239:Lysine / Q000378:metabolism; D009154:Mutation
chemical_list: D000596:Amino Acids; D001426:Bacterial Proteins; D006150:Guanine Nucleotides; D002701:Chloramphenicol; D008239:Lysine