Chartreusin: production and microbiological assay.
Chartreusin was produced in the fermentation liquors of Streptomyces chartreusis at peak concentrations of 200 to 300 mug/ml. The titers could be increased by 200 to 300% or more by incorporating d-fucose, a part of the chartreusin molecule, into the fermentation media. A microbiological assay with Sarcina lutea could detect concentrations of the drug of 0.5 to 1.0 mug/ml.
D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis*; D005643:Fucose / Q000378:metabolism; D006027:Glycosides / Q000096:biosynthesis; D066298:In Vitro Techniques; D008828:Microbiological Techniques; D013302:Streptomyces / Q000378:metabolism*
D000903:Antibiotics, Antineoplastic; D006027:Glycosides; D005643:Fucose