Xeroderma pigmentosum: recent studies on the DNA repair defects.
Xeroderma pigmentosum is a recessive autosomal disease of humans that is characterized by a high prevalence of skin cancers. Results of studies on cells from such patients indicate a defect in the repair of DNA damage associated with exposure to ultraviolet radiation. Since this observation was reported, a large amount of information on this disease has accumulated in the literature.
D002459:Cell Fusion; D004247:DNA / Q000528:radiation effects; D004260:DNA Repair; D004261:DNA Replication; D005816:Genetic Complementation Test; D006801:Humans; D011740:Pyrimidine Dimers / Q000235:genetics; D013942:Thymine Nucleotides / Q000235:genetics; D014466:Ultraviolet Rays; D014983:Xeroderma Pigmentosum / Q000235:genetics*
D011740:Pyrimidine Dimers; D013942:Thymine Nucleotides; D004247:DNA