Tetrahydroisoquinolines in the brain: the basis of an animal model of alcoholism.
Quite surprisingly, the direct introduction of THP into the brain induces a remarkable shift in voluntary alcohol intake... Even as much as 6 mo later, with no further infusions of THP, the remarkable voluntary selection of alcohol did not abate.
D000428:Alcohol Drinking; D000437:Alcoholism / Q000209:etiology*; D000470:Alkaloids / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002243:Carbolines / Q000494:pharmacology; D004195:Disease Models, Animal; D006801:Humans; D007276:Injections, Intraventricular; D007546:Isoquinolines / Q000378:metabolism; D010208:Papaverine / Q000031:analogs & derivatives*; D051381:Rats; D013375:Substance Withdrawal Syndrome; D013765:Tetrahydropapaveroline / Q000494:pharmacology*; D013997:Time Factors
D000470:Alkaloids; D002243:Carbolines; D007546:Isoquinolines; D013765:Tetrahydropapaveroline; D010208:Papaverine