title: Reduction of indomethacin-induced gastrointestinal blood loss by sodium salicylate in man.
abstract: The gastrointestinal bleeding during treatment with indomethacin, aspirin, phenylbutazone and sodium salicylate in healthy human subjects was determined. Gastrointestinal blood loss was determined by the Cr51-labelled erythrocyte method. The method was modified by us. Collected stool was incinerated and radioactivity of ashes was determined. Furthermore, rheumatic patients were treated for 4 weeks with indomethacin alone or with indomethacin combined with sodium salicylate. The gastrointestinal blood loss was determined on the last 4 days of treatment. It was found that blood loss was significantly reduced by combined treatment in comparison to monotherapy with indomethacin, while combined treatment had a marked anti-rheumatic effect.
mesh_terms: D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced / Q000517:prevention & control*; D006801:Humans; D007213:Indomethacin / Q000009:adverse effects / Q000037:antagonists & inhibitors*; D008297:Male; D008875:Middle Aged; D012980:Sodium Salicylate / Q000627:therapeutic use*
chemical_list: D012980:Sodium Salicylate; D007213:Indomethacin