Suppressed immune response to T-cell dependent antigen in chemically sympathectomized mice.
Chemical sympathectomy induced by 6-hydroxydopamine (6-OHDA) suppressed the secondary immune response of mice to a T-cell (thymus derived lymphocyte) dependent antigen, sheep red blood cells (SRBC). Treatment with 6-OHDA on the day of the secondary injection of SRBC resulted in depression of hemagglutinin titers to the antigen, while treatment with 6-OHDA on the day of the primary injection of SRBC had no effect upon the secondary response to the antigen. In addition, 6-OHDA treatment did not suppress the primary immune response to a T-cell independent antigen, Escherichia coli lipopolysaccharide (LPS). These results suggest that it is the T-cells which are mainly affected by chemical sympathectomy. Significant non-specific toxicity was not observed with 6-OHDA 100mg/kg, the dose of which suppressed the primary and the secondary immune response to SRBC.
D000818:Animals; D000906:Antibodies / Q000032:analysis; D000941:Antigens; D004912:Erythrocytes / Q000276:immunology; D004926:Escherichia coli / Q000276:immunology; D005260:Female; D006892:Hydroxydopamines / Q000494:pharmacology; D007109:Immunity / Q000187:drug effects*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009929:Organ Size; D012756:Sheep; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000502:physiology*; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000033:anatomy & histology
D000906:Antibodies; D000941:Antigens; D006892:Hydroxydopamines; D008070:Lipopolysaccharides