Can dopamine beta-hydroxylase levels predict adverse reactions to disulfiram?
Disulfiram had more pronounced sedative effects on healthy normal subjects with low levels of plasma dopamine-beta-hydroxylase (DBH) than it did on subjects with higher levels. It is suggested that DBH levels might provide a means of predicting increased susceptibility to disulfiram side effects.
D000437:Alcoholism / Q000188:drug therapy*; D004221:Disulfiram / Q000009:adverse effects*; D004299:Dopamine beta-Hydroxylase / Q000097:blood*; D006801:Humans; D008297:Male
D004299:Dopamine beta-Hydroxylase; D004221:Disulfiram