Metronidazole prophylaxis for elective large bowel surgery in children: a prospective trial.
In a controlled trial in children aged 2 days to 16 years undergoing large bowel surgery a group of 15 patients had preoperative mechanical bowel preparation and oral neomycin while a second group of 15 patients was similarly prepared but also had preoperative and postoperative metronidazole medication. Five of the 9 postoperative infections in the first group involved Bacteroides spp. but no anaerobe was found in the 3 wound infections in the metronidazole group.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007420:Intestine, Large / Q000601:surgery*; D008297:Male; D008795:Metronidazole / Q000627:therapeutic use*; D009355:Neomycin / Q000627:therapeutic use; D011897:Random Allocation; D013530:Surgical Wound Infection / Q000382:microbiology / Q000517:prevention & control*; D013997:Time Factors
D008795:Metronidazole; D009355:Neomycin