Mechanism of action and mechanism of resistance to antineoplastic agents that bind to DNA.
The interaction with DNA of acridines, actinomycins, anthracylines, and bleomycin causes the inactivation of the DNA template in transcription and replication. The lethal effect is probably related to an irreversible damage to the structure of DNA. The acquisition of resistance is a multistep process in which changes in the uptake of the drug, which are related to basic processes such as ion transport, energy production, and regulation of macromolecular synthesis, have crucial importance.
D000903:Antibiotics, Antineoplastic / Q000378:metabolism / Q000494:pharmacology*; D001692:Biological Transport; D002118:Calcium / Q000378:metabolism; D002463:Cell Membrane Permeability; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004247:DNA / Q000378:metabolism*; D003630:Daunorubicin / Q000494:pharmacology; D004317:Doxorubicin / Q000494:pharmacology; D004351:Drug Resistance
D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin; D004247:DNA; D002118:Calcium; D003630:Daunorubicin