Morphological aspects of the endocrine pancreas in a prednisolone-treated infant.
The endocrine pancreas of a corticosteroid-treated infant during the course of nephrotic syndrome was morphologically studied. Islet cell hyperplasia and dispersed endocrine cell aggregates between acinar tissue were observed. A marked numerical increase of B cells was identified by using cytochemical and immunofluorescent methods. Morphometric data support the morphological observations. The findings suggest that corticosteroid treatment induces endocrine cell replication and neogenesis.
D006801:Humans; D006965:Hyperplasia; D007223:Infant; D007515:Islets of Langerhans / Q000187:drug effects* / Q000473:pathology; D008297:Male; D009404:Nephrotic Syndrome / Q000188:drug therapy / Q000473:pathology; D011239:Prednisolone / Q000494:pharmacology* / Q000627:therapeutic use
D011239:Prednisolone