Chemical and biological consequences of beta-decay. Part 1.
Radioactive decay in a labelled molecule leads to specific chemical and biological consequences which are due to local transmutation effects such as recoil, electronic excitation, build-up of charge states and change of chemical identity, as well as to internal radiolytic effects. In the present paper these effects are reviewed emphasizing the relation of the chemical alterations on a molecular level to the biological manifestation. Potential importance of this type of research for biomedical applications is pointed out. In part 1 we review the underlying physical and chemical principles and consequences of beta-decay of 3H, 14C, 32P, 33P, 35S and 125I for gaseous and simple condensed organic systems. Part 2 which will appear in the next issue will include the discussion of biological effects associated with beta-decay.
D001973:Bromodeoxyuridine / Q000528:radiation effects; D002250:Carbon Radioisotopes; D003596:Cytosine / Q000528:radiation effects; D003857:Deoxyuridine / Q000528:radiation effects; D005609:Free Radicals; D007065:Idoxuridine / Q000528:radiation effects; D007457:Iodine Radioisotopes; D007553:Isotope Labeling; D010636:Phenols / Q000528:radiation effects; D010761:Phosphorus Radioisotopes; D011849:Radioactive Tracers; D011851:Radioactivity; D011868:Radioisotopes; D013386:Succinates / Q000528:radiation effects; D013462:Sulfur Radioisotopes; D013936:Thymidine / Q000528:radiation effects; D014316:Tritium; D014443:Tyrosine / Q000031:analogs & derivatives; D014498:Uracil / Q000031:analogs & derivatives / Q000528:radiation effects
D002250:Carbon Radioisotopes; D005609:Free Radicals; D007457:Iodine Radioisotopes; D010636:Phenols; D010761:Phosphorus Radioisotopes; D011849:Radioactive Tracers; D011868:Radioisotopes; D013386:Succinates; D013462:Sulfur Radioisotopes; D014316:Tritium; D014443:Tyrosine; D014498:Uracil; D003596:Cytosine; D001973:Bromodeoxyuridine; D007065:Idoxuridine; D013936:Thymidine; D003857:Deoxyuridine