Fibrinogen and FDP-E antigen deposits in nephritic kidneys.
Glomerular localization of fibrinogen reactive antigens (FRA) and fibrinogen degradation products reactive antigens (FDP-E) was investigated in 184 renal biopsy specimens of diseased kidneys by an immunofluorescent method. There was clear dissociation of FRA and neoantigen deposits in the glomeruli in a moderately active stage of acute glomerulonephritis, chronic glomerulonephritis and in all 5 cases of lipoid nephrosis. In lupus nephritis and membranous nephropathy there were almost coincident deposits of these antigens.
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000937:Antigen-Antibody Reactions; D000941:Antigens / Q000378:metabolism*; D002908:Chronic Disease; D003928:Diabetic Nephropathies / Q000276:immunology; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism*; D005340:Fibrinogen / Q000378:metabolism*; D005455:Fluorescent Antibody Technique; D005921:Glomerulonephritis / Q000276:immunology; D006801:Humans; D007674:Kidney Diseases / Q000276:immunology*; D007678:Kidney Glomerulus / Q000276:immunology / Q000473:pathology; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009393:Nephritis / Q000209:etiology / Q000276:immunology; D009402:Nephrosis, Lipoid / Q000276:immunology
D000941:Antigens; D005338:Fibrin Fibrinogen Degradation Products; D005340:Fibrinogen