title: The interaction between ethanol and antihistamines. 1: Dexchlorpheniramine.
abstract: Thirteen paid student volunteers (9 male, 4 female) were used in a double-blind crossover experiment to investigate the effects of a therapeutic dose of dexchlorpheniramine alone, and in combination with a social dose of ethanol on perceptual, cognitive and motor functions. Both ethanol (0.75 g/kg) and dexchlorpheniramine (4 mg/70 kg) were given orally. Although a synergistic effect of dexchlorpheniramine with ethanol was only observed in some of the tests, a delayed recovery from the effects of the combination was noted. Subjective data indicated that the sedative effects of dexchlorpheniramine were more pronounced in the presence of ethanol.
mesh_terms: D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D002744:Chlorpheniramine / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D003071:Cognition / Q000187:drug effects; D003864:Depression, Chemical; D004311:Double-Blind Method; D004357:Drug Synergism; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007773:Lactates / Q000097:blood; D008297:Male; D009048:Motor Skills / Q000187:drug effects; D010465:Perception / Q000187:drug effects; D011930:Reaction Time / Q000187:drug effects
chemical_list: D001786:Blood Glucose; D007773:Lactates; D000431:Ethanol; D002744:Chlorpheniramine