title: Radiation induced alterations in the endotoxin of S. typhimurium.
abstract: The lipopolysaccharide (LPS) of S. typhimurium has been shown to be significantly detoxified after in vivo irradiation at 500 krad. Radiation is thus a useful method for converting endotoxin into toxoid. The structural alterations in the detoxified LPS are shown to be mainly in the lipid A molecule, resulting in the loss of beta-hydroxymyristic acid.
mesh_terms: D000818:Animals; D004307:Dose-Response Relationship, Radiation; D004731:Endotoxins / Q000528:radiation effects* / Q000633:toxicity; D008070:Lipopolysaccharides / Q000528:radiation effects / Q000633:toxicity; D051379:Mice; D011135:Polysaccharides, Bacterial / Q000528:radiation effects / Q000633:toxicity; D011829:Radiation Dosage; D012486:Salmonella typhimurium
chemical_list: D004731:Endotoxins; D008070:Lipopolysaccharides; D011135:Polysaccharides, Bacterial