A role of anti-"LD" antibody in induction of active enhancement in rat heart allografts.
Heart allografts from S-D to Wistar rats pretreated with 5 x 10(7) spleen cells taken from donor strain 1 or 2 weeks before, survived indefinitely. Sera taken from the pretreated rats showed high lymphocytotoxic titers and obvious blocking activity against LMC of immunized Wistar spleen cells. Even though the sera were exhaustively absorbed with RBC, this blocking activity was not impaired, although CDC was reduced. The active prolongation of graft survival, therefore, correlates with the presence of anti-LD antibody.
D000818:Animals; D000906:Antibodies; D003602:Cytotoxicity, Immunologic; D006085:Graft Survival; D016027:Heart Transplantation; D008214:Lymphocytes / Q000276:immunology*; D051381:Rats; D014184:Transplantation, Homologous
D000906:Antibodies