Longterm treatment with brompheniramine and phenylpropanolamine in recurrent otitis media--a double-blind study.
A double-blind study has been performed in 44 children with recurrent episodes of otitis media and/or secretory otitis media using a combined preparation of brompheniraminemaleate and phenylpropanolaminehydrocloride (Lunerin mite). No significant prophylactic effect was found on symptoms of respiratory tract infections or middle ear diseases during the trial period of nine months. The result suggests that further critical studies should be performed with such preparations which for the time being are used abundantly for the prevention of middle ear infections or effusions.
D001977:Brompheniramine / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008297:Male; D010033:Otitis Media / Q000188:drug therapy* / Q000517:prevention & control; D010665:Phenylpropanolamine / Q000627:therapeutic use*; D011725:Pyridines / Q000627:therapeutic use*; D012008:Recurrence; D012141:Respiratory Tract Infections / Q000188:drug therapy / Q000517:prevention & control; D013997:Time Factors
D004338:Drug Combinations; D011725:Pyridines; D010665:Phenylpropanolamine; D001977:Brompheniramine