Immunofluorescence localization of thyroglobulin autoantibody producing cells in various organs of obese strain (OS) chickens.
All major lymphoid organs from animals of the Obese strain (OS) of chickens which develop a spontaneous autoimmune thyroiditis with circulating thyroglobulin autoantibodies (Tg-AAb) were investigated for Tg-AAb producing cells using the immunofluorescence method (IF). No Tg-binding cells could be detected in spleen, bursa. Harderian glands, thymus, coecal tonsils or bone marrow. The infiltrated thyroid gland was shown to be the only site of Tg-AAb production detectable by IF.
D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology*; D001323:Autoantibodies; D001853:Bone Marrow / Q000276:immunology; D002060:Bursa of Fabricius / Q000276:immunology; D002645:Chickens / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D006243:Harderian Gland / Q000276:immunology; D009765:Obesity / Q000235:genetics / Q000276:immunology*; D014066:Palatine Tonsil / Q000276:immunology; D013154:Spleen / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology; D013954:Thyroglobulin / Q000276:immunology*; D013961:Thyroid Gland / Q000276:immunology
D001323:Autoantibodies; D013954:Thyroglobulin