[Specific experimental therapy in sensitization to group A streptococci].
A model of delayed hypersensitivity to Streptococcus hemolyticus, group A, were obtained in guinea pigs and rabbits. Studies of spontaneous changes of the immuno-allergic reactivity revealed that after a month of sensitization there developed delayed hypersensitivity only; according to the results of late skin tests it lasted not less than 6 months (the duration of investigation). The delayed hypersensitivity component began to manifest itself in 2 1/2 to 3 months and increased later on. Specific hyposensitization was performed with streptococcus allergens differing by physico-chemical conditions, i.e. the corpuscula allergen, the one that was lysed by ultrasonic waves, and Ando-Verzhikovsky's allergen. The latter had the most intensive hyposensitizing features. Specific hyposensitization was more demonstrative after the intracutaneous long-term course injections of threshold doses. Administration of subthreshold doses, as well as subcutaneous or intravenous injections of the allergen, was ineffective.
D000485:Allergens / Q000008:administration & dosage; D000818:Animals; D003888:Desensitization, Immunologic; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000628:therapy*; D007271:Injections, Intradermal; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D011817:Rabbits; D013297:Streptococcus pyogenes / Q000276:immunology*
D000485:Allergens
Spetsificheskaia eksperimental'naia terapiia pri sensibilizatsii k streptokokku gruppy A.