E. coli endotoxin shock in the dog; treatment with lidocaine or indomethacin.
1 Dogs treated with lidocaine (1 mg kg-1 h-1) or indomethacin (1.5 mg/kg) before and after an LD60 dose (1 mg/kg) of E. coli endotoxin survived for at least 72 h. 2 Although all dogs in both treated groups survived, only those treated with indomethacin were significantly protected against the fall in the arterial blood pressure 1 to 2 min following endotoxin administration. 3 Endotoxin increased the plasma prostaglandin F2alpha (PGF2alpha) concentration in the control and lidocaine-treated groups, however, no increase was observed with indomethacin treatment. 4 Neither lidocaine nor indomethacin alone had any significant effect on the parameters measured in this model. 5 Following the administration of endotoxin, lidocaine-treated animals had significantly decreased plasma fibrinogen concentrations when compared to the other groups. 6 This study suggests that lidocaine, a local anaesthetic and a drug widely used for cardiac arrhythmias, might offer protection in endotoxin shock.
D000818:Animals; D001772:Blood Cell Count; D001777:Blood Coagulation / Q000187:drug effects; D004285:Dogs; D004731:Endotoxins / Q000494:pharmacology; D004926:Escherichia coli; D006439:Hemodynamics / Q000187:drug effects; D007213:Indomethacin / Q000627:therapeutic use*; D008012:Lidocaine / Q000627:therapeutic use*; D008297:Male; D011460:Prostaglandins F / Q000097:blood; D012772:Shock, Septic / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D013997:Time Factors
D004731:Endotoxins; D011460:Prostaglandins F; D008012:Lidocaine; D007213:Indomethacin