Gastrin-producing cells in ectopic gastric mucosa of developmental and metaplastic origins.
Immunocytochemical techniques using antigastrin antibody were employed to localize G cells in ectopic gastric mucosa of metaplastic and congenital origins and to compare their distribution with that in normal gastric mucosa. Five examples of Barrett's esophagus, 8 Meckel's diverticula, and 2 small bowel duplications were studied. Although G cells were absent in the gastric mucosa from all cases of Barett's esophagus, four Meckel's diverticula and one small bowel duplication contained G cells. In all instances of congenitally derived ectopic gastric mucosa where G cells were demonstrable, the gastric mucosa showed areas of antropyloric differentiation, whereas in the remaining cases the ectopic gastric mucosa was exclusively of the body-fundic type. It is concluded that the presence of G cells within ectopic gastric mucosa of Meckel's diverticula and small bowel duplications in foci of antropyloric differentiation reflects their developmental origin, whereas the absence of G cells in Barrett's esophagus is in keeping with its metaplastic derivation.
D002828:Choristoma / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D004935:Esophageal Diseases / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D004947:Esophagus / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D005753:Gastric Mucosa / Q000378:metabolism / Q000473:pathology*; D005755:Gastrins / Q000096:biosynthesis* / Q000378:metabolism; D006652:Histological Techniques; D006801:Humans; D007414:Intestinal Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D007421:Intestine, Small / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D008467:Meckel Diverticulum / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D008679:Metaplasia
D005755:Gastrins