Biologic properties of bacterial lipopolysaccharides treated with chromium chloride.
Addition of small amounts of chromium chloride to a saline suspension of Salmonella typhosa lipopolysaccharide (LPD; Difco) caused a marked reduction in several of the biologic activities of this substance including toxicity, B-cell mitogenicity, plasma colony-stimulating activity (CSA), radioprotective effect, and induction of the dermal Shwartzman reaction. Nevertheless, LPS treated with chromium chloride was found to be at least as effective as untreated LPS in enhancing resistance of B6CBF1 mice to the lethal effects of Klebsiella pneumoniae infection.
D000276:Adjuvants, Immunologic; D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects; D002857:Chromium / Q000494:pharmacology*; D007710:Klebsiella Infections / Q000517:prevention & control; D007711:Klebsiella pneumoniae; D007928:Lethal Dose 50; D008070:Lipopolysaccharides / Q000276:immunology* / Q000633:toxicity; D051379:Mice; D011135:Polysaccharides, Bacterial / Q000276:immunology* / Q000633:toxicity; D011833:Radiation Injuries, Experimental / Q000517:prevention & control; D011837:Radiation-Protective Agents; D012485:Salmonella typhi; D012790:Shwartzman Phenomenon
D000276:Adjuvants, Immunologic; D008070:Lipopolysaccharides; D011135:Polysaccharides, Bacterial; D011837:Radiation-Protective Agents; D002857:Chromium