The use of dobutamine in myocardial infarction for reversal of the cardiodepressive effect of metoprolol.
1 Ten patients with acute myocardial infarction were infused dobutamine in increasing doses up to 15 microgram kg--1 min--1. 2 Metoprolol (total dose 15 mg) was then given intravenously to nine of these patients and the beta-adrenoceptor against effects produced by dobutamine were effectively reversed. 3 Nine patients with acute myocardial infarction pretreated with metoprolol (15 mg) were infused dobutamine 15 microgram kg--1 min--1 for 10 min. This resulted in effective reversal of the beta-adrenoceptor antagonist effects induced by metoprolol, without the occurrence of serious arrhythmias or other unwanted effects. 4 Dobutamine may be valuable in counteracting any undesirable cardiodepressive effects of beta-adrenergic receptor blocking drugs (especially the cardioselective agents) in patients with acute myocardial infarction.
D000208:Acute Disease; D000328:Adult; D000368:Aged; D002395:Catecholamines / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004280:Dobutamine / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008790:Metoprolol / Q000009:adverse effects / Q000037:antagonists & inhibitors* / Q000627:therapeutic use; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology; D011412:Propanolamines / Q000037:antagonists & inhibitors*
D002395:Catecholamines; D011412:Propanolamines; D004280:Dobutamine; D008790:Metoprolol