A simple allogeneic test system for the study of antibody-dependent cellular cytotoxicity (ADCC) in man.
A simple allogeneic test system for the study of ADCC activity of human mononuclear peripheral blood leucocytes (MPBL) is presented. The test uses human Rh-positive erythrocytes as target cells coated with specific human IgG antibody. The effector function of human MPBL is demonstrated after depletion of most of the monocytes and B lymphocytes on nylon wool column. The test system seems to be useful in the clinical study of ADCC activity in man.
D000920:Antibody-Dependent Cell Cytotoxicity; D004912:Erythrocytes / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G; D007158:Immunologic Techniques
D007074:Immunoglobulin G