Gastrointestinal complications of immunodeficiency syndromes.
Patients with B cell deficiency have a high incidence of prolonged Giardia lamblia infection of the gastrointestinal tract that causes symptoms of malabsorption with villus flattening. The changes are reversible with therapy directed against Giardia. There is a high incidence of pernicious anaemia in patients with agammaglobulinaemia. Those with abnormal B lymphocytes tend to develop lymphoid nodular hyperplasia. Gastrointestinal disease is rare in boys with X-linked agammaglobulinaemia when compared with adults with the 'acquired' or common variable form of the disease. T cell deficiency results in intractable diarrhoea and monilial infection of the gastrointestinal tract.
D000293:Adolescent; D000328:Adult; D000361:Agammaglobulinemia / Q000150:complications; D000752:Anemia, Pernicious / Q000209:etiology; D001402:B-Lymphocytes; D001424:Bacterial Infections / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D003967:Diarrhea / Q000209:etiology; D005512:Food Hypersensitivity / Q000209:etiology; D005767:Gastrointestinal Diseases / Q000209:etiology*; D005770:Gastrointestinal Neoplasms / Q000209:etiology; D005873:Giardiasis / Q000209:etiology; D005983:Glutens / Q000009:adverse effects; D006801:Humans; D006965:Hyperplasia; D007153:Immunologic Deficiency Syndromes / Q000150:complications*; D007223:Infant; D007421:Intestine, Small / Q000473:pathology; D008107:Liver Diseases / Q000209:etiology; D008221:Lymphoid Tissue / Q000473:pathology; D008231:Lymphopenia / Q000150:complications; D008297:Male; D013601:T-Lymphocytes
D005983:Glutens