Circulating IgA anti-basement membrane zone antibodies in dermatitis herpetiformis.
Criculating anti-basement membrane zone antibodies of the IgA class were detected in the sera of 2 or 6 dermatitis herpetiformis (DH) patients who had linear in-vivo-bound IgA deposits and in 1 of 42 DH patients who had granular vivo-bound IgA deposits. In the former 2 patients the circulating antibodies were localized ultrastructurally to the identical site where the in vivo-bound antibodies were localized and were bound by antigens in either the lamina lucida or the subbasal lamina anchoring fibril area of the basement membrane zone of normal human skin.
D001485:Basement Membrane / Q000276:immunology*; D001666:Binding Sites, Antibody; D003874:Dermatitis Herpetiformis / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D012867:Skin / Q000648:ultrastructure
D007070:Immunoglobulin A