The first step in the activation of chicken pepsinogen is similar to that of prochymosin.
Chicken pepsinogen was incubated at pH2.5 with pepstatin. The zymogen activated itself by a sequential mechanism and an intact peptide derived from residues 1-26 in the protein was released in the first step. This peptide was found to inhibit the milk-clotting activities of pig and chicken pepsins and calf chymosin but to different extents.
D000595:Amino Acid Sequence; D000818:Animals; D002645:Chickens; D002850:Chromatography, Gel; D012085:Chymosin / Q000037:antagonists & inhibitors; D004789:Enzyme Activation; D010434:Pepsin A / Q000037:antagonists & inhibitors; D010435:Pepsinogens / Q000378:metabolism*; D010436:Pepstatins; D010455:Peptides / Q000378:metabolism / Q000494:pharmacology
D010435:Pepsinogens; D010436:Pepstatins; D010455:Peptides; D010434:Pepsin A; D012085:Chymosin