title: [Oral treatment of great ichthyotic disorders by ethylester retinoid (author's transl)].
abstract: Observations of 3 different great ichthyotic disorders, no longer responding to local keratolytics and to oral vitamin A are reported: a case of erythrokeratoderma variabilis, one of ichthyosiform erythroderma, and one of bullous ichthyosiform hyperkeratosis. After a week of oral treatment by the ethylester retinoid (Ro 10-9359), the hyperkeratotic component of each disease already improved dramatically. A maintenance treatment had to be continued. With equal or superior keratolytic effects, the retinoid has lower toxicity and less important side-effects than retinoic acid itself. The ethylester retinoid is nowadays the choice oral treatment in these great hyperkeratotic disorders.
mesh_terms: D000293:Adolescent; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007057:Ichthyosis / Q000188:drug therapy* / Q000473:pathology; D012872:Skin Diseases, Vesiculobullous / Q000188:drug therapy* / Q000473:pathology; D014212:Tretinoin / Q000627:therapeutic use*; D014801:Vitamin A / Q000031:analogs & derivatives*
chemical_list: D014801:Vitamin A; D014212:Tretinoin
vernacular_title: Traitement oral de grands états ichtyosiformes par le rétinoïde éthylester.