Malignant neoplasms following cardiac transplantation.
Between Jan 6, 1968, and April 11, 1977, 124 patients underwent cardiac transplantation at Stanford University Medical Center, with a mean and median period of follow-up of 18.3 and 9.7 months, respectively. Malignant neoplasms developed in seven patients--three lymphoproliferative neoplasms, two skin cancers, one acute leukemia, and one colon carcinoma. Visceral tumors were often fatal and caused 11% of deaths after three months following transplantation. The incidence and spectrum of malignant neoplasms in this population are similar to those observed in recipients of renal homografts.
D000293:Adolescent; D000328:Adult; D003110:Colonic Neoplasms / Q000209:etiology; D016027:Heart Transplantation; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D007938:Leukemia / Q000209:etiology; D008223:Lymphoma / Q000209:etiology; D008875:Middle Aged; D009369:Neoplasms / Q000209:etiology*; D011183:Postoperative Complications; D012306:Risk; D012878:Skin Neoplasms / Q000209:etiology; D014184:Transplantation, Homologous