Absorption, distribution and elimination of cefazolin in patients with normal renal function.
Cefazolin was given intramuscularly in a dosage of 1.0 g to 13 bed-ridden patients during treatment for various infections, and the pharmacokinetics evaluated in each subject. In 9 patients the mean serum half-life was 2.7 h, whereas in 4 patients--all over 60 years of age--it was significantly above this value. Impaired renal fuction could not explain the prolonged excretion time in the last group.
D000042:Absorption; D000293:Adolescent; D000367:Age Factors; D000368:Aged; D002437:Cefazolin / Q000008:administration & dosage / Q000378:metabolism* / Q000627:therapeutic use; D002511:Cephalosporins / Q000378:metabolism*; D002986:Clinical Trials as Topic; D003404:Creatinine / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate; D006207:Half-Life; D006801:Humans; D007273:Injections, Intramuscular; D007668:Kidney / Q000378:metabolism*; D007677:Kidney Function Tests; D007700:Kinetics; D008297:Male; D008875:Middle Aged
D002511:Cephalosporins; D003404:Creatinine; D002437:Cefazolin