Ability of chloramphenicol to suppress phenotypically some bacterial mutations.
Chloramphenicol (CLP) at slightly inhibitory concentrations (3-5 microgram/ml) suppresses the inhibition of DNA synthesis and cell division caused by the temperature sensitive mutation dnaE486 at the nonpermissive temperature. Some other mutations can also be phenotypically suppressed by CLP. A similar effect is shown by chlortetracycline. Phenotypic suppression is caused by both these drugs in different cases than by streptomycin.
D002701:Chloramphenicol / Q000494:pharmacology*; D002751:Chlortetracycline / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics; D009154:Mutation / Q000187:drug effects*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D013307:Streptomycin / Q000494:pharmacology
D002701:Chloramphenicol; D002751:Chlortetracycline; D013307:Streptomycin