title: Prophylactic effect of lithium and imipramine in unipolar and bipolar II patients: a preliminary report.
abstract: Relapse rates of the first 35 unipolar and bipolar II manic-depressive patients who entered the controlled phase of a continuing evaluation of the prophylactic value of lithium alone or in combination with imipramine were analyzed. Lithium had a prophylactic effect in unipolar patients and possibly in bipolar II patients. Imipramine did not have a prophylactic effect in either group of patients.
mesh_terms: D001714:Bipolar Disorder / Q000517:prevention & control*; D002986:Clinical Trials as Topic; D003863:Depression / Q000517:prevention & control*; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D006801:Humans; D007099:Imipramine / Q000627:therapeutic use*; D008094:Lithium / Q000627:therapeutic use*; D010919:Placebos
chemical_list: D010919:Placebos; D008094:Lithium; D007099:Imipramine