Activation of distinct helper and suppressor T cells in experimental trypanosomiasis.
Spleen cells taken from mice soon after infection with Trypanosoma brucei S 42 enhance the primary in vitro antibody response of normal spleen cells to sheep red blood cells (SRBC), but do not affect their response to DNP-Ficoll. Spleen cells harvested later in the infection (day 6 onwards) suppress the antibody response of normal spleen cells to both SRBC and DNP-Ficoll. The enhancing and suppressive effects of "infected" spleen cells are sensitive to treatment with anti-Thy 1.2 anti-serum and complement, and can be mediated by nylon wool-purified populations of T cells. The enhancing T cell is sensitive to ALS, not lost within 4 weeks of adult thymectomy, and bears the Ly-1+, 23- phenotype. The suppressor T cell is insensitive to ALS, lost within 20 weeks of adult thymectomy, and bears the Ly-1+, 23+ phenotype. The significance of the activation of distinct helper and suppressor T cells is discussed in relation to the pathogenesis of trypanosomiasis.
D000818:Animals; D000961:Antilymphocyte Serum / Q000494:pharmacology; D002417:Cattle; D006462:Hemolytic Plaque Technique; D007165:Immunosuppression Therapy; D008211:Lymphocyte Cooperation; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013601:T-Lymphocytes / Q000276:immunology*; D013934:Thymectomy; D014346:Trypanosoma brucei brucei / Q000276:immunology; D014354:Trypanosomiasis, Bovine / Q000276:immunology*
D000961:Antilymphocyte Serum