Acetylcholine and cholinesterase in submandibular glands of rats given armin and obidoxime.
The effects of obidoxime, a pyridinium oxime, on the cholinesterase activity and acetylcholine content of the submandibular glands of rats poisoned with armin, an organophosphorus anticholinesterase agent, were studied. The results indicate that obidoxime-induced reactivation of phosphorylated cholinesterase can suppress completely the increase in the concentration of acetylcholine that develops within the submandibular gland after administration of armin alone.
D000109:Acetylcholine / Q000032:analysis*; D000818:Animals; D001138:Armin / Q000494:pharmacology*; D002800:Cholinesterase Inhibitors; D002802:Cholinesterases / Q000378:metabolism*; D004793:Enzyme Reactivators; D005260:Female; D008297:Male; D009768:Obidoxime Chloride / Q000494:pharmacology*; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D010091:Oximes / Q000494:pharmacology*; D051381:Rats; D013363:Submandibular Gland / Q000032:analysis / Q000187:drug effects* / Q000201:enzymology
D002800:Cholinesterase Inhibitors; D004793:Enzyme Reactivators; D009943:Organophosphorus Compounds; D010091:Oximes; D009768:Obidoxime Chloride; D002802:Cholinesterases; D001138:Armin; D000109:Acetylcholine