Transitory IgA-deficiency, persistent IgE deficiency and recurrent respiratory tract infectious disease after splenectomy.
In a 14 year old boy, a ruptured spleen was removed. Two months after the splenectomy he developed recurrent infections of the respiratory tract. A deficiency of IgA and IgE in his blood serum was found. His impaired resistance to respiratory tract infections responded well to substitution therapy with IgA. Spontaneous clinical recovery occurred during 3 years after the splenectomy, and was parallelled by a slow return of IgA to normal levels, whereas the absence of IgE persisted. The identical twin brother of the patient, who had his spleen intact, had normal levels of serum IgA and did not suffer from frequent respiratory tract inflammations.
D000293:Adolescent; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D004406:Dysgammaglobulinemia / Q000209:etiology*; D006801:Humans; D007070:Immunoglobulin A / Q000302:isolation & purification*; D007073:Immunoglobulin E / Q000302:isolation & purification*; D008297:Male; D011183:Postoperative Complications; D012008:Recurrence; D012141:Respiratory Tract Infections / Q000209:etiology*; D013156:Splenectomy / Q000009:adverse effects*; D013161:Splenic Rupture / Q000601:surgery; D013997:Time Factors
D007070:Immunoglobulin A; D007073:Immunoglobulin E