Effect of intrahypothalamic phentolamine on hypothermia produced by peripheral noradrenaline in the pigeon.
1 The effect of intrahypothalamic phentolamine (1 and 1 microliter of a 10 microgram/microliter solution) on hypothermia induced by intramuscular injection of noradrenaline (NA, 2 mg/kg) at different times (2, 10, 20 min) after phentolamine was investigated in pigeons. 2 Administration of phentolamine shortly before NA was shown to attenuate hypothermic responses to NA. 3 It is suggested that the attenuation is due to blockade of central hypothermic effects of intramuscular NA. 4 The mapping of injection sites in the brains was carried out.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D010856:Columbidae / Q000502:physiology*; D005260:Female; D007031:Hypothalamus; D007267:Injections; D007273:Injections, Intramuscular; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects; D010646:Phentolamine / Q000008:administration & dosage / Q000494:pharmacology*; D013238:Stereotaxic Techniques
D009638:Norepinephrine; D010646:Phentolamine