title: Comparative natriuretic and diuretic efficacy of theophylline ethylenediamine and of bendroflumethiazide during long-term treatment with the potent diuretic bumetanide. Permutation trial tests in patients with congestive heart failure.
abstract: The additive natriuretic and diuretic effects of theophylline ethylenediamine and of bendroflumethiazide have been compared in permutation trial tests in patients with advanced congestive heart failure receiving long-term treatment with the highly potent diuretic, bumetanide. Statistical analysis of renal water and electrolyte excretion revealed that theophylline ethylenediamine, 400 mg orally, and bendroflumethiazide, 5 mg orally, had very similar effects, both quantitatively and qualitatively. The mechanism of action of the supplementary diuretics is discussed. It is concluded that theophylline ethylenediamine represents a useful alternative to thiazide diuretics when supplementary natriuretic treatment is considered in patients with congestive heart failure during long-term treatment with potent diuretics. The significance of maintaining the potassium balance during such a combined regimen is stressed.
mesh_terms: D001539:Bendroflumethiazide / Q000008:administration & dosage / Q000627:therapeutic use*; D002034:Bumetanide / Q000008:administration & dosage / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004231:Diuresis / Q000187:drug effects; D004232:Diuretics / Q000627:therapeutic use*; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D004573:Electrolytes / Q000652:urine; D005029:Ethylenediamines / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006333:Heart Failure / Q000188:drug therapy* / Q000652:urine; D006801:Humans; D008297:Male; D008875:Middle Aged; D009318:Natriuresis / Q000187:drug effects; D013806:Theophylline / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D004232:Diuretics; D004573:Electrolytes; D005029:Ethylenediamines; D002034:Bumetanide; D001539:Bendroflumethiazide; D013806:Theophylline