An immunohematologic complication of isoniazid.
The characteristics of an immunohematologic reaction to isoniazid are described with emphasis on the mechanism of development of the positive antiglobulin test. In contrast to previous findings, the antibody is a firmly bound IgG complement-binding antibody, reacting best at 37 degrees C by antiglobulin techniques and only with isoniazid presensitized cells. A method for preparing isoniazid-sensitized cells is described.
D000328:Adult; D000917:Antibody Formation; D000918:Antibody Specificity; D000936:Antigen-Antibody Complex; D000941:Antigens; D002462:Cell Membrane / Q000276:immunology; D003165:Complement System Proteins; D003298:Coombs Test; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G; D007158:Immunologic Techniques; D007538:Isoniazid / Q000009:adverse effects* / Q000276:immunology / Q000627:therapeutic use; D014376:Tuberculosis / Q000188:drug therapy
D000936:Antigen-Antibody Complex; D000941:Antigens; D007074:Immunoglobulin G; D003165:Complement System Proteins; D007538:Isoniazid