[Pharmacokinetics of ticarcillin in patients with normal and impaired renal function (author's transl)].
Elimination half-life of ticarcillin was measured in 61 patients with different levels of renal function after intravenous rapid infusion (1--20 g). Assuming a single-compartment model for elimination, there was in those without renal disease a half-life of approximately 71 minutes, although there were considerable individual variations. In patients with impaired renal function (glomerular filtration rate 30--60 ml/min) the values were between 60 and 120 minutes, while in one patient with a filtration rate of 2.08 ml/min it was over 400 min. If there is a correlation between dose and half-life, it was obscured by the individual variations. Distribution volume was 21 1/100 kg body-weight.
D001424:Bacterial Infections / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D003404:Creatinine / Q000097:blood / Q000652:urine; D004305:Dose-Response Relationship, Drug; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D010406:Penicillins / Q000378:metabolism*; D013982:Ticarcillin / Q000008:administration & dosage / Q000378:metabolism*
D010406:Penicillins; D003404:Creatinine; D013982:Ticarcillin
Die Pharmakokinetik von Ticarcillin be Patienten mit normaler und eingeschräkter Nierenfunktion.