[Toxicity of oximes and their effect on acetylcholinesterase activity in the blood and myoneural synapses of animals].
The effect was followed up of 2-PAM and Toxogonin (T), reactivators of choline esterase, at a single muscular application on the activity of acetylcholine esterase (ES 3.1.1.7) (ACE) of whole blood (WB) and the myoneural synapses (MS) of an interrib muscle. It was found that a species-specific effect was produced by T and 2-PAM on ACE of WB and MS in lambs and sheep. Optimal doses of 50 and 80 mg/kg led to a slight drop in the activity of ACE at the 2nd hour following injection, after which it rose gradually up to values that were higher than the initial ones for more than ten days. 100 and 200 mg/kg led to a more sensitive and long-term drop in the activity of ACE (up to 48h--72nd hour), after which it likewise rose above the initial value, and came back to normal on the 13th day. With lambs the reaction was analogous, though weaker. In rats and rabbits there was no change in the activity of ACE of WB and MS following the use of oximes. The optimal nontoxic and inductoenzyme rates of the two oximes for lambs and sheep proved to be about 50 mg/kg. It was established that both for rats and for sheep and lambs T was almost twice as toxic as 2-PAM. Intoxication with T was characterized by severe hemorrhagic and necrotic nephroso-nephritis, acute toxic dystrophy of the liver, and ulcerous, necrotic enteritis. 2-PAM was found to potentiate the toxic effect of T.
D000110:Acetylcholinesterase / Q000097:blood*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation / Q000187:drug effects; D007928:Lethal Dose 50; D009469:Neuromuscular Junction / Q000187:drug effects* / Q000201:enzymology; D009768:Obidoxime Chloride / Q000633:toxicity; D010091:Oximes / Q000633:toxicity*; D011220:Pralidoxime Compounds / Q000633:toxicity; D011817:Rabbits; D051381:Rats; D012756:Sheep; D013997:Time Factors
D010091:Oximes; D011220:Pralidoxime Compounds; D009768:Obidoxime Chloride; D000110:Acetylcholinesterase
Vurkhu toksichnostta na niakoi oksimi i vliianieto im vurkhu aktivnostta na atsetilkholinesterazata v kruvta i mionevralnite sinapsi nazhivotnite.