Coxsackievirus aggregates in muscle cells of a polymyositis patient.
Muscle biopsy specimens of a patient with polymyositis showed crystalline structures resembling picornavirus aggregates within muscle cells. The patient's serum reacted in an indirect immunofluorescence assay with autologous muscle cells. A strongly positive immunofluorescence staining was also noted when a section of muscle tissue was reacted with coxsackievirus A9 antiserum, and a weakly positive reaction was noted with coxsackievirus B2 antiserum. No staining was observed after treatment with antiserum to poliovirus type 1 or echovirus types 11 and 22.
D000368:Aged; D000914:Antibodies, Viral; D001707:Biopsy, Needle; D003384:Coxsackievirus Infections / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005455:Fluorescent Antibody Technique; D006801:Humans; D008297:Male; D009132:Muscles / Q000276:immunology / Q000473:pathology / Q000648:ultrastructure; D009220:Myositis / Q000175:diagnosis*; D010300:Parkinson Disease / Q000175:diagnosis*
D000914:Antibodies, Viral