[Comparative study of the effect of different rifamycins on bacterial cell metabolism and on the RNA-polymerase reaction in a cell-free system].
The results of the study on the inhibitory effect of a number of rifamycin derivatives, such as rifamycin B, rifamycin O, rifamycin, rifamycin A, 25-desacetylrifampicin and rifampicin are presented. It was shown that rifampicin had the highest inhibitory effect on the synthesis of RNA in the cells of E. coli and Staph. aureus. It inhibited the above process by 93.0 and 98.8 per cent respectively. The data on the cells of Staph. aureus, as well as the data on comparison of the inhibitory effect of rifampicin derivatives with respect to the RNA-polymerase reaction in acellular systems are presented.
D002474:Cell-Free System / Q000187:drug effects; D012321:DNA-Directed RNA Polymerases / Q000037:antagonists & inhibitors*; D004926:Escherichia coli / Q000187:drug effects* / Q000378:metabolism; D046911:Macromolecular Substances; D012329:RNA, Bacterial / Q000037:antagonists & inhibitors; D012294:Rifamycins / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000378:metabolism
D046911:Macromolecular Substances; D012329:RNA, Bacterial; D012294:Rifamycins; D012321:DNA-Directed RNA Polymerases
Sravnitel'noe izuchenie vliianie razlichnkh rifamitsinov na metabolizm bakterial'nykh kletok i RNK-polimeraznuiu reaktsiiu v beskletochnoĭ sisteme.