Dietary factors in the aetiology of gastrointestinal cancer.
Gastrointestinal cancers, mainly oesophageal, gastric, pancreatic and large bowel cancer, account for about 40,000 deaths annually in England and Wales which is 32% of all cancer deaths. Nutritional factors have been implicated in the cause of each cancer and probably act by promoting the effect of carcinogenic substances taken in the diet or produced in the gut. Gastric cancer for example may be due to nitrosamine production in the stomach. This is enhanced by readily available sources of dietary nitrite and nitrate whilst the reaction is inhibited by vitamin C and low temperatures (2 degrees C). By contrast large bowel cancer can be related to high fat and meat intakes whilst a protective role for dietary fibre has been suggested. Dietary factors in the aetiology of oesophageal cancer differ from one high incidence area to another.
D000818:Animals; D001205:Ascorbic Acid / Q000627:therapeutic use; D003080:Cold Temperature; D004032:Diet / Q000009:adverse effects*; D004041:Dietary Fats / Q000009:adverse effects; D004043:Dietary Fiber / Q000627:therapeutic use; D004064:Digestive System / Q000503:physiopathology; D004938:Esophageal Neoplasms / Q000209:etiology; D005769:Gastrointestinal Motility; D005770:Gastrointestinal Neoplasms / Q000209:etiology* / Q000378:metabolism / Q000628:therapy; D006801:Humans; D007414:Intestinal Neoplasms / Q000209:etiology; D008460:Meat / Q000009:adverse effects; D009602:Nitrosamines / Q000506:poisoning; D009928:Organ Specificity; D010190:Pancreatic Neoplasms / Q000209:etiology; D013274:Stomach Neoplasms / Q000209:etiology
D004041:Dietary Fats; D004043:Dietary Fiber; D009602:Nitrosamines; D001205:Ascorbic Acid