Baclofen trial in six myotonic dystrophy patients.
Six young adult patients with grade I myotonic dystrophy and a complaint of daytime somnolence underwent 36-hour polygraphic monitoring, dynamometric and electromyographic studies before and under baclofen (60 mg/daily). Patients with the most severe daytime sleepiness had pathologic Sleep Apnea Indexes. After 6 weeks' ingestion of baclofen, no subjective or objective effect on patient symptomatology was found.
D000293:Adolescent; D000328:Adult; D000613:Aminobutyrates / Q000627:therapeutic use*; D001418:Baclofen / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D006801:Humans; D008297:Male; D008991:Monitoring, Physiologic; D009223:Myotonic Dystrophy / Q000188:drug therapy*; D012893:Sleep Wake Disorders / Q000188:drug therapy
D000613:Aminobutyrates; D001418:Baclofen