Pituitary adenomas and dyspituitarism.
Recent studies of the structure and function of pituitary adenomas reveal that the majority are functional and that the commonest type is a prolactin secreting adenoma. Studies of hypothalamic-pituitary function provide evidence to suggest that the adenoma develops following prolonged hypothalamic stimulation of the pituitary gland, and that the clinical dyspituitarism is due to the hypothalamic-pituitary dysfunction and not to pituitary destruction by the adenoma. Pituitary adenomas may be classified into those due to a basic neuroendocrine dysfunction (prolactin secreting, acromegaly, Cushing's disease) and those arising secondary to end-organ failure (TSH and FSH secreting). The former group have APUD characteristics and may form part of a pluriglandular syndrome of apudomas. The persistence of a basic neuroendocrine dysfunction following the surgical removal of an adenoma explains the frequent recurrence of symptoms in patients and indicates a need for continued surveillance and long-term therapy.
D000172:Acromegaly / Q000209:etiology; D000236:Adenoma / Q000209:etiology / Q000503:physiopathology*; D000818:Animals; D002648:Child; D003480:Cushing Syndrome / Q000209:etiology; D006801:Humans; D010906:Pituitary Hormone-Releasing Hormones / Q000378:metabolism; D010908:Pituitary Hormones, Anterior / Q000378:metabolism*; D010911:Pituitary Neoplasms / Q000209:etiology / Q000503:physiopathology*; D011388:Prolactin / Q000378:metabolism; D051381:Rats
D010906:Pituitary Hormone-Releasing Hormones; D010908:Pituitary Hormones, Anterior; D011388:Prolactin