[Long term course of insulin secretion in treated non-insulin dependent diabetics (author's transl)].
The long-term effects of sulfonamides were studied by means of hyperinsulinemia tests in 82 diabetics over a period of 12 months (24 months for 30 of them). Whereas for those (obese) diabetes whose only treatment was dieting--alone or combined with biguanides--hyperinsulinemia attenuates itself as do also variations in glycemia, although some asynchronism remains, in those diabetics treated with sulfonamides--alone or in combination with other treatments--the insulinemia curve is hardly modified.
D001645:Biguanides / Q000627:therapeutic use; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000503:physiopathology / Q000628:therapy*; D003927:Diet, Diabetic; D004359:Drug Therapy, Combination; D005947:Glucose; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D013449:Sulfonamides / Q000627:therapeutic use; D013997:Time Factors
D001645:Biguanides; D007328:Insulin; D013449:Sulfonamides; D005947:Glucose
Evolution a long terme de l'insulino-sécrétion chez le diabétique non insulino-dépendant traité.