Inhibition by paromomycin of R-factor transfer of tetracycline resistance between Escherichia coli and Salmonella pullorum.
In vitro assays showed that low concentrations (5--10 and 20 microgram/ml) of the antimicrobial paromomycin sulfate are able to block or diminish significantly the transfer of the tetracycline resistance R-factor between Escherichia coli and Salmonella pullorum. This observation is important because it offers the possibility of preventing the formation of tetracycline-resistant pathogens, a limiting factor of tetracycline use in both human and veterinary medicine.
D003090:Coliphages / Q000302:isolation & purification; D003227:Conjugation, Genetic; D003864:Depression, Chemical; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics; D010303:Paromomycin / Q000494:pharmacology*; D011815:R Factors / Q000187:drug effects*; D012475:Salmonella / Q000187:drug effects* / Q000235:genetics; D013754:Tetracyclines / Q000494:pharmacology*
D013754:Tetracyclines; D010303:Paromomycin