Formaldehyde induced anti-N: a possible cause of renal graft failure.
Treatment of human red cells with low concentrations of formaldehyde induces an antigenic change which makes them react very strongly with the anti-N sera found in certain patients treated by haemodialysis. This supports the idea that formaldehyde sterilisation of reusable home dialysers leads to the development of anti-N in these patients' sera. The clinical problems produced by this antibody are discussed together with ways of overcoming them.
D000917:Antibody Formation; D004912:Erythrocytes / Q000187:drug effects / Q000276:immunology; D005557:Formaldehyde / Q000009:adverse effects / Q000494:pharmacology*; D006084:Graft Rejection; D006801:Humans; D016030:Kidney Transplantation; D008951:MNSs Blood-Group System; D006435:Renal Dialysis / Q000009:adverse effects; D013242:Sterilization
D008951:MNSs Blood-Group System; D005557:Formaldehyde