Possible use of short-term tests for carcinogens in experimental epidemiology.
This brief overview pointed out the feasibility of applying the recently developed short-term bioassays for carcinogens/mutagens to the field of epidemiology. The simplicity and economy of these test systems permitted their adaptation for large-scale screening for intrinsic and extrinsic carcinogens with an eye to detecting subpopulations with elevated sensitivity to particular carcinogens.
D000818:Animals; D001711:Biotransformation; D002274:Carcinogens, Environmental / Q000378:metabolism / Q000506:poisoning; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D004260:DNA Repair; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D004812:Epidemiologic Methods; D006801:Humans; D066298:In Vitro Techniques; D051379:Mice; D008862:Microsomes, Liver / Q000378:metabolism; D009153:Mutagens; D009369:Neoplasms / Q000139:chemically induced*; D051381:Rats; D013997:Time Factors
D002274:Carcinogens, Environmental; D009153:Mutagens