A comparison of a WI-38 vaccine and duck embryo vaccine for preexposure rabies prophylaxis.
Two types of rabies vaccine, WI-38 vaccine (WRV) and Duck Embryo Vaccine (DEV) were compared in rabies preexposure prophylaxis. Once group of veterinary students received four doses of DEV, a second group received four doses of WRV, and a third group received two doses of WRV. Adverse reactions were found to be similar for all three gorups. The antibody responses, however, differed markedly: the mean neutralizing titer after four doses of DEV was 1:75, after four doses of WRV was 1:1517, but was only 1:164 after two doses of WRV. All students who received three or four doses of WRV developed high titers of rabies antibody, making this vaccine very desirable for preexposure prophylaxis.
D000328:Adult; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004372:Ducks; D004622:Embryo, Mammalian; D004625:Embryo, Nonmammalian; D005347:Fibroblasts; D006801:Humans; D008297:Male; D011818:Rabies / Q000276:immunology / Q000517:prevention & control*; D011819:Rabies Vaccines / Q000009:adverse effects / Q000627:therapeutic use*; D013334:Students; D014730:Veterinary Medicine
D000914:Antibodies, Viral; D011819:Rabies Vaccines