Topographical ventilation and perfusion distribution during IPPB in the lateral posture.
We measured topographical ventilation and perfusion distribution in the gravity field using 133Xe in 5 normal subjects either during natural breathing or during intermittent positive pressure ventilation (IPPB) in the lateral decubitus posture. The ratio of ventilation of upper regions to that of lower regions increased from 0.61 +/- 0.10 (mean +/- SE) during natural breathing to 0.95 +/- 0.08 during IPPB. In contrast, the ratio of regional perfusion was unchanged in the 2 conditions. Consequently, distribution of regional ventilation-perfusion ratios became less homogeneous during IPPB. Whereas during natural breathing the ratio of ventilation-perfusion of upper regions to that of lower regions was 1.09 +/- 0.18, during IPPB this ratio was 1.52 +/- 0.14. Despite the differences in regional ventilation distribution between natural breathing and IPPB, analysis of multiple-breath 133Xe washouts measured at the mouth did not reveal any difference. The results are consistent with the hypothesis that the magnitude of diaphragmatic tension is the main determinant of topographical ventilation distribution in the lateral posture.
D006801:Humans; D007384:Intermittent Positive-Pressure Breathing; D008297:Male; D011175:Positive-Pressure Respiration; D011187:Posture; D012123:Pulmonary Ventilation; D012119:Respiration; D013990:Tidal Volume; D014692:Ventilation-Perfusion Ratio; D014980:Xenon Radioisotopes
D014980:Xenon Radioisotopes