The protective effect of endogenous interferon in mouse malaria, as demonstrated by the use of anti-interferon globulins.
Both death rate and percentage of parasitized erythrocytes in mice infected with Plasmodium berghei were enhanced by injections of anti-interferon globulins. As, in the same time, parasite-induced interferon was neutralized by these globulins, it can be concluded that endogenous interferon plays an important inhibiting role during parasitic diseases, such as malaria, as it has been previously demonstrated in many virus infections.
D000818:Animals; D005916:Globulins / Q000494:pharmacology*; D007372:Interferons / Q000037:antagonists & inhibitors / Q000097:blood / Q000276:immunology*; D008288:Malaria / Q000276:immunology*; D051379:Mice; D010962:Plasmodium berghei
D005916:Globulins; D007372:Interferons