Maintenance of spermatogenesis induced by HMG treatment by means of continuous HCG treatment in hypogonadotrophic men.
In a long-term hypophysectomized male HCG treatment was unable to initiate spermatogenesis. However, a spermatogenesis induced by HMG/HCG treatment could be maintained by HCG alone for 7 years with clinical fertility. In another hypogonadotrophic male HCG was also unable to initiate spermatogenesis. But a spermatogenesis once induced by HMG/HCG treatment could be maintained for more than one year with HCG alone. It is suggested that gonadotrophin treatment of the hypogonadotrophic male should consist of HMG + HCG until complete spermatogenesis is induced followed by maintenance treatment with HCG.
D000328:Adult; D006063:Chorionic Gonadotropin / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D006801:Humans; D007006:Hypogonadism / Q000188:drug therapy*; D007016:Hypophysectomy; D008297:Male; D008596:Menotropins / Q000627:therapeutic use*; D013091:Spermatogenesis / Q000187:drug effects*
D006063:Chorionic Gonadotropin; D008596:Menotropins