title: Chromosomal mutants of Saccharomyces cerevisiae affecting the cell wall binding site for killer factor.
abstract: Fifty-two killer, factor-resistant, nuclear mutants were isolated from sensitive strains of yeast and assorted into three functional groups. All but one mutant owed their resistance to an alteration in the cell wall binding site for killer. In several mutant strains, an alteration at the site of killer binding was associated with a change in the susceptibility of the cell wall to degradation by glusulase. The killer-binding site could be inactivated by periodate but not by pronase treatment. The nature of the site is discussed.
mesh_terms: D001665:Binding Sites / Q000187:drug effects; D002473:Cell Wall / Q000187:drug effects / Q000378:metabolism; D004352:Drug Resistance, Microbial; D005816:Genetic Complementation Test; D009154:Mutation; D009183:Mycotoxins / Q000235:genetics* / Q000378:metabolism / Q000494:pharmacology; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000235:genetics* / Q000378:metabolism
chemical_list: D009183:Mycotoxins