Transplantation of the left lung into the right hemithorax to facilitate immediate reconstitution of bronchial artery flow.
Immediate bronchial artery reconstitution may be important in the prevention of bronchial anastomotic problems in lung transplantation. To facilitate this reconstitution in circumstances requiring allograft replacement of the right lung, we developed a method for transplanting the left lung together with its bronchial arterial supply into the right hemithorax. With this method, left lungs were allotransplanted into the right hemithorax of nine immunosuppressed dogs. Six recipients survived 1 to 4 weeks. Death resulted from pneumonia or rejection, and there were no bronchial anastomotic problems. Roentgenograms showed that the bronchial artery was patent and that the inverted transplanted left lungs could conform exactly to the thorax without space problems or radiographic abnormalities. Except for the unusual position of the large pulmonary arteries, angiographic patterns, function, and perfusion of the transplanted lungs were often normal and equivalent to those of the recipient's normal left lung. Thus it is possible to transplant a left lung into either hemithorax and immediately reconstitute its bronchial arterial circulation. Bronchial anastomotic problems may thereby be decreased.
D000818:Animals; D001013:Aorta, Thoracic / Q000637:transplantation; D001981:Bronchial Arteries / Q000000981:diagnostic imaging / Q000637:transplantation*; D004285:Dogs; D006084:Graft Rejection; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D016040:Lung Transplantation; D011651:Pulmonary Artery / Q000000981:diagnostic imaging / Q000637:transplantation; D011859:Radiography; D014184:Transplantation, Homologous