The threonine-sensitive homoserine dehydrogenase and aspartokinase activities of Escherichia coli K12. Carboxymethylation of a unique cysteine induces a conformational change of the enzyme.
D000478:Alkylation; D001225:Aspartokinase Homoserine Dehydrogenase / Q000037:antagonists & inhibitors*; D003545:Cysteine; D004229:Dithiothreitol; D004926:Escherichia coli / Q000201:enzymology*; D006714:Homoserine; D007461:Iodoacetates; D007700:Kinetics; D009097:Multienzyme Complexes / Q000037:antagonists & inhibitors*; D011487:Protein Conformation / Q000187:drug effects
D007461:Iodoacetates; D009097:Multienzyme Complexes; D006714:Homoserine; D001225:Aspartokinase Homoserine Dehydrogenase; D003545:Cysteine; D004229:Dithiothreitol