title: The lymphoid system. Its normal architecture and the potential for understanding the system through the study of lymphoproliferative diseases.
abstract: This article presents a view of lymphoid tissue architecture as defined by the traffic of defined lymphoid cell classes. The compartmentalization of lymphocytes is discussed in reference to specific cell-cell interactions that occur in antigen-driven immune responses. Finally, the distribution of normal and neoplastic lymphocytes in humans is defined and compared with animal model systems.
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D005455:Fluorescent Antibody Technique; D006801:Humans; D007136:Immunoglobulins; D008206:Lymphatic Diseases / Q000276:immunology* / Q000473:pathology; D008208:Lymphatic System / Q000033:anatomy & histology / Q000276:immunology* / Q000473:pathology; D008214:Lymphocytes / Q000276:immunology* / Q000473:pathology; D008223:Lymphoma / Q000276:immunology / Q000473:pathology; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D007136:Immunoglobulins