title: Methylphenidate in hyperkinetic children: differences in dose effects on learning and social behavior.
abstract: Methylphenidate (Ritalin) is widely prescribed for hyperkinetic children. This study showed a peak enchancement of learning in children after being given a dose of 0.3 milligram per kilogram of body weight, and a decrement in learning in those given larger doses; social behavior showed the most improvement in children given 1.0 milligram per kilogram. These results had been hypothesized from theoretical dose-response curves which indicate different target behaviors would improve at different doses.
mesh_terms: D002648:Child; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D006948:Hyperkinesis / Q000188:drug therapy*; D007858:Learning / Q000187:drug effects*; D008774:Methylphenidate / Q000008:administration & dosage* / Q000627:therapeutic use; D012919:Social Behavior
chemical_list: D008774:Methylphenidate