Iron-poly (sorbitol-gluconic acid) complex and iron-dextran in the treatment of severe iron deficiency anaemia.
An investigation has been carried out to study the efficacy of iron-poly (sorbitol-gluconic acid) complex (Ferastral) in the treatment of iron deficiency anaemia. Ferastral was given by the intramuscular route every second or third day in a dose of 500 mg, divided in two injections. These were compared with the results of a group treated with iron-dextran given by Total Dose Infusion (TDI). A total of 38 patients were treated with either Ferastral or iron-dextran by TDI, respectively, given according to random allocation. The total dose of iron given in both groups was 1 500 mg of elemental iron. The parameters investigated were haematocrit and haemoglobin. Side-effects were also recorded. The results in the group treated with Ferastral where the mean initial haemoglobin value was 9.5 g/100 ml showed a mean haemoglobin increase to 13.2 g/100 ml after eight weeks. Initial haemoglobin values and haemoglobin increase for iron-dextran by TDI were quite similar. Three patients in the Ferastral group had transient discolouration at the site of injection and one patient in the iron-dextran TDI-group had a serious allergic reaction.
D000747:Anemia, Hypochromic / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D004338:Drug Combinations; D004341:Drug Evaluation; D004342:Drug Hypersensitivity; D005260:Female; D005942:Gluconates / Q000627:therapeutic use; D006454:Hemoglobins / Q000096:biosynthesis; D006801:Humans; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D007501:Iron / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D007505:Iron-Dextran Complex / Q000627:therapeutic use*; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D011247:Pregnancy; D013012:Sorbitol / Q000627:therapeutic use; D013924:Thrombophlebitis / Q000139:chemically induced; D014581:Urticaria / Q000139:chemically induced
D004338:Drug Combinations; D005942:Gluconates; D006454:Hemoglobins; D013012:Sorbitol; D007505:Iron-Dextran Complex; D007501:Iron