Design of liposomes for enhanced local release of drugs by hyperthermia.
Liposomes can be designed to release an entrapped drug preferentially at temperatures attainable by mild local hyperthermia. In a test system in vitro, protein synthesis by Escherichia coli is inhibited and killing of the cells is enhanced by heating neomycin-containing liposomes to their phase transition temperature to maximize drug release. In the presence of serum the ratio of release at 44 degrees C to that at 37 degrees C can be made greater than 100:1, suggesting possible applications in the treatment of tumors or local infection.
D004926:Escherichia coli / Q000187:drug effects; D005334:Fever / Q000503:physiopathology*; D008081:Liposomes / Q000627:therapeutic use*; D008954:Models, Biological; D009355:Neomycin / Q000008:administration & dosage; D014677:Pharmaceutical Vehicles; D011663:Pulmonary Surfactants / Q000627:therapeutic use; D013010:Sonication; D013696:Temperature
D008081:Liposomes; D014677:Pharmaceutical Vehicles; D011663:Pulmonary Surfactants; D009355:Neomycin