title: Optimal flow pattern for mechanical ventilation of the lungs. 2. The effect of a sine versus square wave flow pattern with and without an end-inspiratory pause on patients.
abstract: In four series of patients, the efficiency of ventilation of a sine wave without an end-inspiratory pause was compared to a square wave without a pause, a sine wave with a pause to a square wave with a pause, a sine wave to a sine wave with a pause, and a sine wave with a long pause to one with a short pause.  The primary mode of evaluation was through simultaneous airway and arterial argon washout curves. Additional cardiopulmonary measurements were made. Results indicate: (1) a statistically significant improvement in ventilation with a sine wave with a pause; (2) a statistically significant improvement with the longer pause as compared to the short pause.
mesh_terms: D000328:Adult; D000368:Aged; D001128:Argon / Q000097:blood; D002245:Carbon Dioxide / Q000097:blood; D002302:Cardiac Output; D002986:Clinical Trials as Topic; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D012123:Pulmonary Ventilation; D012121:Respiration, Artificial / Q000379:methods*; D013147:Spirometry; D014692:Ventilation-Perfusion Ratio
chemical_list: D002245:Carbon Dioxide; D001128:Argon; D010100:Oxygen