Renal transplantation and pregnancy.
Processing of data from 79 pregnancies (incl. 11 observed by the authors) in 64 women (incl. 6 of their own patients) after renal transplantation revealed that approximately in 20% of the pregnancies in chronological association with the pregnancy the function of the graft deteriorated or ceased and in four instances this participated indirectly in the mother's death within one year after delivery. The effect of immunosuppressive treatment of the pregnant mother on the development of the foetus and 57 evaluated infants resp. was manifested by a 50% incidence of prematurity, in seven neonates by clinical or post-mortem findings of adrenal hypofunction or hypoplasia resp. and by hypofunction or hypoplasia of the lymphatic apparatus. Only in one neonate and one foetus (observed by the authors) an inborn defect was revealed. In five neonates chromosomal aberrations were described. The above findings support our disapproval of pregnancy in women after renal transplantation with the exception of recipients of grafts from siblings with closely related tissue properties and with a renal function stabilized for a long period and with minimal immunosuppression.
D002869:Chromosome Aberrations; D005260:Female; D005333:Fetus / Q000187:drug effects; D006084:Graft Rejection; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D007668:Kidney / Q000503:physiopathology; D016030:Kidney Transplantation; D008428:Maternal Mortality; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D013997:Time Factors; D014184:Transplantation, Homologous