Bone marrow origin of hepatic macrophages (Kupffer cells) in humans.
Hepatic macrophages (Kupffer cells) from two male recipients of bone marrow transplants from females were studied for fluorescent Y body staining and sex chromatin (Barr body). After the transplant, macrophages had the sex karyotype of the donor, indicating that human hepatic macrophages originate in bone marrow.
D000293:Adolescent; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D002454:Cell Differentiation; D002465:Cell Movement; D005260:Female; D006086:Graft vs Host Disease / Q000276:immunology; D006801:Humans; D007728:Kupffer Cells / Q000166:cytology*; D008297:Male; D014184:Transplantation, Homologous