[Treatment of severe haemolytic-uraemic syndrome by dialysis (author's transl)].
Since 1973 haemodialysis was performed on 30 children with severe haemolytic-uraemic syndrome. Serial measurements were made of blood pressure, blood picture, renal function, complement values, excretion of fibrinogen split-products and beta2-microglobulin in urine. Of 22 children in the acute severe stage two died, in one case treatment having been started too late, in the other as a result of fulminating pneumococcal pneumonia. Twenty children survived without residual symptoms and with normal renal function. Of six children with severe progressive haemolytic-uraemic syndrome two developed terminal renal failure. In one child a renal transplantation has since been performed. One child requires chronic dialysis after nephrectomy. Three children died as a result of arterial hypertension, one of yeast septicaemia. Of two children with recurrent haemolytic-uraemic syndrome one developed terminal renal failure which was successfully treated by renal transplantation. One child died in a hypertensive crisis. The overall death rate of the group was 23%, in the group with the acute severe haemolytic-uraemic syndrome it was 9%. The results suggest that haemodialysis significantly improves the prognosis of severe haemolytic-uraemic syndrome.
D001794:Blood Pressure; D002648:Child; D002675:Child, Preschool; D003165:Complement System Proteins / Q000032:analysis; D005338:Fibrin Fibrinogen Degradation Products / Q000652:urine; D006463:Hemolytic-Uremic Syndrome / Q000150:complications / Q000175:diagnosis / Q000628:therapy* / Q000652:urine; D006801:Humans; D007223:Infant; D007676:Kidney Failure, Chronic / Q000150:complications; D011018:Pneumonia, Pneumococcal / Q000150:complications; D011379:Prognosis; D006435:Renal Dialysis; D014184:Transplantation, Homologous; D001613:beta 2-Microglobulin / Q000652:urine
D005338:Fibrin Fibrinogen Degradation Products; D001613:beta 2-Microglobulin; D003165:Complement System Proteins
Dialysebehandlung des schweren hämolytisch-urämischen Syndroms.