title: Effective protection against influenza after vaccination with subunit vaccine.
abstract: Immunization with an influenza subunit vaccine given in one dose about 1 month to 2 months before onset of an epidemic of influenza afforded from 80% to 90% protection in a double-blind clinical trial which was supported by isolation of virus and serological studies. In the vaccinated group, 20% failed to develop antibodies to the vaccine. Either serology tests or attempted isolation of virus alone would have failed to detect some of the cases.
mesh_terms: D000914:Antibodies, Viral / Q000096:biosynthesis; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006801:Humans; D009980:Influenza A virus / Q000276:immunology; D007252:Influenza Vaccines / Q000627:therapeutic use*; D007251:Influenza, Human / Q000453:epidemiology / Q000517:prevention & control*; D014611:Vaccination
chemical_list: D000914:Antibodies, Viral; D007252:Influenza Vaccines