Inhibitors of folate biosynthesis. 1. Inhibition of dihydroneopterin aldolase by pteridine derivatives.
2-Amino-6-carboxamido-7,8-dihydropteridin-4-one and 2-amino-6-hydroxymethyl-7,7-dimethyl-7,8-dihydropteridin-4-one have been shown to be good inhibitors of Escherichia coli dihydroneopterin aldolase, an early enzyme of de novo folate biosynthesis.
D000446:Aldehyde-Lyases / Q000037:antagonists & inhibitors*; D004926:Escherichia coli / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D005492:Folic Acid / Q000096:biosynthesis*; D011621:Pteridines / Q000494:pharmacology*
D011621:Pteridines; D005492:Folic Acid; D000446:Aldehyde-Lyases