Protection of mice against malaria by a killed vaccine: differences in effectiveness against P. yoelii and P. berghei.
(C57BI x Balb/c)F1 mice are normally killed by a strain of the malaria P. yoelii, but they can be fully protected by a killed vaccine. The best results were obtained with saponin-lysed parasitized cells subsequently fixed with 0-06% formalin and injected intravenously with the adjuvant B. pertussis, though good protection was also obtained without the adjuvant. The protection was specific and at least partly mediated by a serum factor. A similar regime gives little or no protection against P. berghei. Possible reasons for this difference are considered and the mechanisms by which vaccination works against P. yoelii are discussed.
D000818:Animals; D001428:Bacterial Vaccines; D007116:Immunization, Passive; D008288:Malaria / Q000517:prevention & control*; D051379:Mice; D010961:Plasmodium / Q000276:immunology; D010962:Plasmodium berghei / Q000276:immunology; D013045:Species Specificity; D014611:Vaccination
D001428:Bacterial Vaccines