Initial response to drugs in depressive illness and psychiatric and community adjustment a year later.
Three hundred and sixty depressed in-patients initially treated with imipramine, chlorpromazine or a placebo were re-evaluated a year later. Patients showing the poorest adjustment at one year were those who failed to show a good initial response to treatment and those who responded positively to a placebo.
D000275:Adjustment Disorders / Q000188:drug therapy; D000328:Adult; D000341:Affective Disorders, Psychotic / Q000188:drug therapy; D002746:Chlorpromazine / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003863:Depression / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006778:Hospitals, Psychiatric; D006801:Humans; D007099:Imipramine / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000188:drug therapy; D012917:Social Adjustment
D007099:Imipramine; D002746:Chlorpromazine