title: Experimental nephropathy induced in the rabbit by immunization with a lipopolysaccharide from Escherichia coli.
abstract: Twenty rabbits were each injected with 100 microgram of lipopolysaccharide from Escherichia coli 055 at weekly intervals for up to 15 months. The antisera showed an immunologic cross-reactivity with rabbit kidney glycoprotein. A macroscopic nephropathy was present in 14 of the 17 rabbits in which the kidneys were examined. All the rabbits showed extensive histologic lesions involving all the structures of the kidney: organized thrombosis of the arteries, extensive areas of infarction, glomerular atrophy, tubular necrosis and proliferation of young connective tissue. A marked infiltration with lymphoid cells and some plasmacytes was present. The immunologic character of this nephropathy and the immunopathogenic mechanism involved in its pathogenesis are discussed.
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology; D000937:Antigen-Antibody Reactions; D004926:Escherichia coli / Q000276:immunology*; D006023:Glycoproteins / Q000276:immunology; D007114:Immunization; D007668:Kidney / Q000187:drug effects* / Q000276:immunology; D008070:Lipopolysaccharides / Q000009:adverse effects*; D011817:Rabbits
chemical_list: D000907:Antibodies, Bacterial; D006023:Glycoproteins; D008070:Lipopolysaccharides