The effect of residual insulin secretion on exocrine pancreatic function in juvenile-onset diabetes mellitus.
Residual beta cell function was studied in 18 juvenile-onset diabetics by measuring serum C-peptide immunoreactivity (CPR) fasting, and after IV injection of glucagon (1 mg). This was compared with the exocrine pancreatic response to an IV infusion of secretin and cholecystokinin-pancreozymin. Outputs of pancreatic bicarbonate, amylase and trypsin were measured. Exocrine secretory pancreatic function was decreased in 14 patients. Fasting and maximal CPR showed that 9 patients had residual insulin secretion. For these 'CPR-secretors' there was a strong correlation between CPR and output of bicarbonate (r = 0.87, p less than 0.005) and amylase (r = 0.7, p less than 0.05), but not with trypsin. These results suggest the existence of an endocrine-exocrine relationship in the pancreas.
D000293:Adolescent; D000328:Adult; D000681:Amylases / Q000378:metabolism; D001639:Bicarbonates / Q000378:metabolism; D002096:C-Peptide / Q000097:blood; D002766:Cholecystokinin / Q000494:pharmacology; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D005260:Female; D005934:Glucagon / Q000494:pharmacology; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000378:metabolism*; D012633:Secretin / Q000494:pharmacology; D014357:Trypsin / Q000378:metabolism
D001639:Bicarbonates; D002096:C-Peptide; D007328:Insulin; D012633:Secretin; D005934:Glucagon; D002766:Cholecystokinin; D000681:Amylases; D014357:Trypsin