Comparative ultrastructural morphology of aurosomes produced by colloidal gold and soluble gold salts.
Intra-articular administration of colloidal gold produced aurosomes which contained spherical electron-dense granules and also often some very fine electron-dense particles. Intra-articular administration of aurothioglucose produced aurosomes of a morphology similar to that reported to occur after administration of sodium aurothiomalate. These aurosomes produced by soluble gold salts are characterised by particle and granule-studded membranous formations which present in profile as rod-like and curled filamentous structures. On the basis of morphological differences two types of aurosomes should be recognised, the "Type I or granular aurosome" and the "Type II or membranous aurosome".
D000818:Animals; D006051:Aurothioglucose / Q000494:pharmacology*; D005260:Female; D006046:Gold / Q000494:pharmacology*; D007270:Injections, Intra-Articular; D008247:Lysosomes / Q000187:drug effects / Q000648:ultrastructure*; D008297:Male; D008854:Microscopy, Electron; D011817:Rabbits; D013583:Synovial Membrane / Q000648:ultrastructure
D006051:Aurothioglucose; D006046:Gold