title: A multicentre randomized double-blind study comparing two dosages of levamisole in rheumatoid arthritis.
abstract: A six-centre study was conducted to evaluate the effectiveness and safety of a single weekly treatment with 50 or 150 mg levamisole in patients with rheumatoid arthritis (RA). The results were compared with those of a previous placebo-controlled study, in which 150 mg levamisole was given on 3 or 7 consecutive days each week. The efficacy/side effect ratio is better with 150 mg once weekly than with 150 mg on 3 or 7 consecutive days each week. A reduction of the dose to 50 mg reduces the incidence of idiosyncratic reactions but also reduces efficacy. A single dose of 150 mg levamisole once weekly is therefore recommended as a standard dose in patients with RA. This regimen allows for hematological controls at critical times and, hence, permits recognition in practice of agranulocytosis at the incipient stage.
mesh_terms: D000328:Adult; D001172:Arthritis, Rheumatoid / Q000175:diagnosis / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007978:Levamisole / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male
chemical_list: D007978:Levamisole