On the metabolic characteristics of hybrids Shigella flexneri x Escherichia coli, devoid of their ability for intracellular multiplication in the epithelial cells. IV. Growth characteristics in the presence of some tricarboxylic acid cycle intermediates.
The dynamics of avirulent xyl-str and xyl + hybrids Sh. flexneri was investigated in minimal medium in the presence of some tricarboxylic acid cycle intermediates (succinate, malate, fumarate) and pyruvate. It was established that the hybrids with a replaced xyl-str or xyl-region show a considerably lower rate of multiplication in artificial media than the virulent recipient strains.
D002455:Cell Division; D004926:Escherichia coli / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism; D005650:Fumarates / Q000378:metabolism; D006824:Hybridization, Genetic; D008293:Malates / Q000378:metabolism; D011773:Pyruvates / Q000378:metabolism; D012763:Shigella flexneri / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism; D013386:Succinates / Q000378:metabolism
D005650:Fumarates; D008293:Malates; D011773:Pyruvates; D013386:Succinates