The excretional patterns of lactate, pyruvate and alpha-ketoglutarate in renal transplants.
The excretional patterns of lactate, pyruvate and alpha-ketoglutarate were investigated after renal transplantation in 36 patients. Fourteen patients had received a living-donor kidney with short ischemia time and good initial graft function, 22 had a cadaver transplant with an initial 125iothalamate clearance of more than 6 ml/min. The excretion of lactate and pyruvate did not vary significantly from that seen in normal controls or patients with uremia. In six patients with cadaver transplants, clearance values of alpha-ketoglutarate exceeded that of the glomerular filtration rate, indicating a net tubular secretion of this substance. During acute rejection episodes in 5 patients, no changes were seen in the excretional patterns of lactate, pyruvate and alpha-ketoglutarate.
D000293:Adolescent; D000328:Adult; D005260:Female; D005919:Glomerular Filtration Rate; D006084:Graft Rejection; D006801:Humans; D007656:Ketoglutaric Acids / Q000652:urine*; D016030:Kidney Transplantation; D007773:Lactates / Q000652:urine*; D008297:Male; D008875:Middle Aged; D011773:Pyruvates / Q000652:urine*; D013997:Time Factors; D014184:Transplantation, Homologous
D007656:Ketoglutaric Acids; D007773:Lactates; D011773:Pyruvates