The pharmacology of amblyopia.
Physiologic and anatomic evidence has suggested an anatomic disconnection between the deprived eye and visual cortical neurons in cats made amblyopic by monocular deprivation. Clinical and visual-evoked response data suggest, however, that inhibition may play a major role in amblyopia. Accordingly, we intravenously administered anti-inhibitory compounds (bicuculline, ammonium ion, naloxone) to amblyopic cats and demonstrated a substantial restoration of binocular input to the visual cortex. Such pharmacologic reversal suggests that amblyopia is not an anatomically fixed lesion.
D000328:Adult; D000550:Amblyopia / Q000188:drug therapy* / Q000209:etiology; D000613:Aminobutyrates / Q000037:antagonists & inhibitors*; D000818:Animals; D001640:Bicuculline / Q000494:pharmacology / Q000627:therapeutic use; D002415:Cats; D002648:Child; D018756:GABA Antagonists; D006801:Humans; D009270:Naloxone / Q000494:pharmacology / Q000627:therapeutic use; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology / Q000627:therapeutic use; D012683:Sensory Deprivation; D014785:Vision, Ocular / Q000187:drug effects*; D014792:Visual Acuity; D014793:Visual Cortex / Q000187:drug effects
D000613:Aminobutyrates; D018756:GABA Antagonists; D000644:Quaternary Ammonium Compounds; D009270:Naloxone; D001640:Bicuculline