[Determination of the microbial contamination of tablets of tetracycline series antibiotics].
The experiments showed that the method of direct plating of tetracycline tablet suspensions on solid nutrient media containing magnesium sulfate may be used for determination of microbial contamination. The method provided determination of both the antibiotic resistant and the antibiotic sensitive organisms which may be present in the drug. Dilution of the basic suspensions increased the probability of the microbe detection in the tablets.
D004305:Dose-Response Relationship, Drug; D004340:Drug Contamination; D004926:Escherichia coli / Q000302:isolation & purification; D013210:Staphylococcus / Q000302:isolation & purification; D013607:Tablets; D013754:Tetracyclines / Q000032:analysis*
D013607:Tablets; D013754:Tetracyclines
Opredelenie mikrobnoĭ obsemennosti tabletok antibiotikov tetratsiklinovogo riada.