Effect of mianserin hydrochloride on peripheral uptake mechanisms for noradrenaline and 5-hydroxytryptamine in man.
1. Mianserin seems to have little effect on peripheral noradrenaline (NA) re-uptake mechanisms as shown by its lack of effects on the tyramine dose and NA dose/pressor response. 2. Mianserin has no effect on the hypotensive action of bethanidine. 3. Mianserin in vivo has a significant action on platlet transport (Vmax) of 5-hydroxytryptamine (5-HT), which changes toward normal values in depressive patients on the drug. This action is not observed in vitro. 4. It is possible that a metabolite of mianserin is responsible for this effect, and that this may be of therapeutic importance.
D000928:Antidepressive Agents; D001627:Bethanidine / Q000037:antagonists & inhibitors; D001792:Blood Platelets / Q000378:metabolism; D002986:Clinical Trials as Topic; D003863:Depression / Q000097:blood; D003984:Dibenzazepines / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood; D008297:Male; D008803:Mianserin / Q000378:metabolism / Q000494:pharmacology*; D009638:Norepinephrine / Q000378:metabolism*; D010919:Placebos; D012701:Serotonin / Q000378:metabolism*
D000928:Antidepressive Agents; D003984:Dibenzazepines; D010919:Placebos; D008803:Mianserin; D012701:Serotonin; D001627:Bethanidine; D009638:Norepinephrine