Gastric mucosal cell proliferation and immunoglobulin-containing cells in Ménétriér's Disease.
The amount of immunoglobulin-containing cells in gastric mucosa from 6 patients with Ménétriér's disease was estimated. Furthermore, the rate of gastric epithelial cell proliferation was sutdied in 4 of the patients. Fluorescent antisera specifically reacting with IgA, IgG and IgM were applied, and accordingly the cells were differentiated and quantitated. Other biopsies were labelled in vitro with 3H-thymidine and autoradiographs were prepared. The percentage of DNA-synthesising cells in the progenitor cell region was estimated. The number of IgM-containing cells in the gastric fundic mucosa was markedly increased, while the rate of epithelial cell proliferation was increased in 2 cases and within normal range in the remaining 2 patients.
D000328:Adult; D000368:Aged; D001345:Autoradiography; D002455:Cell Division; D005455:Fluorescent Antibody Technique; D005753:Gastric Mucosa / Q000276:immunology / Q000473:pathology*; D005756:Gastritis / Q000276:immunology / Q000473:pathology*; D006801:Humans; D006984:Hypertrophy; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis; D008297:Male; D008875:Middle Aged
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins