title: [Early death of pancreatic A-cells after irradiation with supralethal doses].
abstract: For investigation of postirradiation reactions, of pancreatic insular cells, male Wistar rats were subjected to 1.5, 3, 7, and 15 kR  of Co60 gamma-radiation. It was found that after application of doses of 7 kR or higher, interphase death of all the insular A-cells occurred within 6 hours. The cell death was demonstrated to be characterized by chromatin pycnosis, dilatation of the endoplasmic reticulum and perinuclear space, mitochondrial swelling, and desintegration of A-granules. Macrophages took no part in resorption of the dead cells. A-cell necrosis was not accompanied by morphologically observable changes in acinar cells or insucar B-cells. Some possible explanations of the more pronounced radiosensitivity of A-cells are discussed.
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000528:radiation effects; D003037:Cobalt Radioisotopes / Q000008:administration & dosage*; D007515:Islets of Langerhans / Q000473:pathology / Q000528:radiation effects / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000473:pathology*; D051381:Rats; D013997:Time Factors
chemical_list: D003037:Cobalt Radioisotopes
vernacular_title: Ranniaia gibel' A-kletok podzheludochnoĭ zhelezy pri obluchenii v supraletal'nykh dozakh.