Principles of albumin and IgG analyses in neurological disorders. III. Evaluation of IgG synthesis within the central nervous system in multiple sclerosis.
Fifty-nine multiple sclerosis patients were investigated with regard to blood-brain barrier function by determining the CSF-protein and the CSF/S albumin ratio. Abnormal values were found in 19% and 32% respectively. The occurrence of CSF-IgG elevation due to synthesis within the CNS was analysed by determining the CSF IgG/protein and CSF IgG/albumin ratios and the IgG-index = (CSF/S IgG ratio)/(CSF/S albumin ratio). Increased values were found in 75%, 80% and 86%, respectively. Oligoclonal IgG was found in CSF by agarose gel electrophoresis in 88% of the patients. The IgG-index is the parameter recommended for the demonstration of an IgG elevation in CSF due to synthesis within the CNS.
D000328:Adult; D000418:Albumins / Q000134:cerebrospinal fluid; D001812:Blood-Brain Barrier; D002490:Central Nervous System / Q000378:metabolism*; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis; D002986:Clinical Trials as Topic; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis*; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D012709:Serum Albumin / Q000032:analysis
D000418:Albumins; D002556:Cerebrospinal Fluid Proteins; D007074:Immunoglobulin G; D012709:Serum Albumin