title: Sulfametopyrazine prophylaxis in chronic bronchitis.
abstract: From a double-blind randomized controlled trial by 32 general practitioners on 218 patients with chronic bronchitis it appeared that sulfametopyrazine given once a week over one winter reduced the number of respiratory illnesses and the loss of time from work to about half that of a control group. It had no effect on time off work in individual spells of illness nor on the amount and purulence of sputum. Side-effects were few and mild.
mesh_terms: D000328:Adult; D000368:Aged; D001991:Bronchitis / Q000517:prevention & control*; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D013415:Sulfalene / Q000009:adverse effects / Q000627:therapeutic use*; D013424:Sulfanilamides / Q000627:therapeutic use*
chemical_list: D013424:Sulfanilamides; D013415:Sulfalene