Epilepsy and IgA deficiency--the effect of sodium valproate.
IgA deficiency (less than 80 IU/ml serum) occurred in 29% of 41 epileptic patients on anticonvulsant therapy. Sodium valproate users had significantly lower mean IgA levels (102 IU/ml) than non-users (151 IU/ml) and had a significantly higher incidence of IgA deficiency (50%) than non-users (16%). The occurrence of IgA deficiency did not appear to be related to age, sex, number of drugs used or to serum anticonvulsant levels.
D000328:Adult; D000361:Agammaglobulinemia / Q000139:chemically induced*; D002220:Carbamazepine / Q000097:blood; D004827:Epilepsy / Q000097:blood*; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D008297:Male; D010634:Phenobarbital / Q000097:blood; D010672:Phenytoin / Q000097:blood; D014631:Valerates / Q000009:adverse effects*; D014635:Valproic Acid / Q000009:adverse effects* / Q000097:blood
D007070:Immunoglobulin A; D014631:Valerates; D002220:Carbamazepine; D014635:Valproic Acid; D010672:Phenytoin; D010634:Phenobarbital