Effect of bovine pancreatic polypeptide on gastric acid and pepsin output in man.
Bovine pancreatic polypeptide was infused intravenously in 16 healthy volunteers at a mean dose of 218 pmol/kg/hr, producing plasma levels similar to those after meals. Basal and pentagastrin-stimulated acid and pepsin outputs and plasma gastrin concentrations were unchanged by BPP. Pancreatic polypeptide is unlikely to be an important physiological modulator of these secretions in man.
D000328:Adult; D000818:Animals; D002417:Cattle; D005750:Gastric Juice / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D010191:Pancreatic Polypeptide / Q000494:pharmacology*; D010418:Pentagastrin / Q000494:pharmacology; D010434:Pepsin A / Q000378:metabolism*
D010191:Pancreatic Polypeptide; D010434:Pepsin A; D010418:Pentagastrin