Frameshift mutations in bacteria produced in the dark by several furocoumarins; absence of activity of 4,5',8-trimethylpsoralen.
4 furocoumarins, namely psoralen (P), 8-methoxypsoralen (8-MOP), 4,5',8-trimethylpsoralen (TMP) and angelicin (A) were tested for dark mutagenesis in E. coli lac-. Three compounds; P, 8-MOP and A were shown to be weak frame-shift mutagens. TMP, surprisingly in view of its very active photosensitizing action, was found to be non-mutagenic. These results are discussed in relation to the photosensitizing action of the furocoumarins.
D003624:Darkness; D004353:Drug Evaluation, Preclinical; D004926:Escherichia coli / Q000187:drug effects; D011564:Furocoumarins / Q000494:pharmacology*; D005815:Genetic Code; D008730:Methoxsalen / Q000494:pharmacology; D009153:Mutagens; D009154:Mutation; D014158:Transcription, Genetic; D014307:Trioxsalen / Q000494:pharmacology
D011564:Furocoumarins; D009153:Mutagens; C011659:angelicin; D008730:Methoxsalen; D014307:Trioxsalen