[Clinical pharmacokinetics of azabutyron, a new short-term action neuroleptic].
Pharmacokinetics of azabutyron--a new Soviet-made neuroleptic was studied clinically without anesthesia and also during surgery against the background of deep and surface fluorothan anesthesia in conjunction with artificial nitrous oxide and oxygen ventilation of the lungs (2:1). After intravenous administration of the drug in a dose of 4 mg/kg its maximum concentration (about 8 gamma/ml) was recorded in 5 minutes and the amount eliminated during 2 hours of observation comprised 1--2 per cent of the dose introduced. In practically healthy individuals with no anesthesia the pharmacokinetics of azabutyron lies within the limits of a bicompartment pharmacokinetics model, while surface anesthesia, blood loss changes the pharmacokinetics of the drug to such an extent that is has to be described from the standpoint of the unicompartment model system.
D000328:Adult; D001372:Aza Compounds / Q000378:metabolism*; D001702:Biopharmaceutics; D002090:Butyrophenones / Q000378:metabolism*; D002986:Clinical Trials as Topic; D006801:Humans; D007275:Injections, Intravenous; D007700:Kinetics; D008875:Middle Aged; D008954:Models, Biological; D010879:Piperazines / Q000378:metabolism; D013997:Time Factors; D014149:Tranquilizing Agents
D001372:Aza Compounds; D002090:Butyrophenones; D010879:Piperazines; D014149:Tranquilizing Agents
Klinicheskaia farmakokinetika azabutirona--novogo neiroleptika kratkovremennogo deĭstviia.