Yeast mutants with distorted cell membranes as a detection system for antitumor antibiotics.
Yeast mutants with distorted cell membranes, which are selectively inhibited by anticancer antibiotics and are not affected by antibacterial antibiotics, could be of considerable interest as test organisms. They could be used for the isolation of active antitumor substances from complex mixtures of natural compounds.
D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D002360:Carubicin / Q000031:analogs & derivatives / Q000494:pharmacology; D002462:Cell Membrane / Q000187:drug effects; D004353:Drug Evaluation, Preclinical / Q000379:methods; D009154:Mutation / Q000187:drug effects; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000235:genetics / Q000648:ultrastructure
D000903:Antibiotics, Antineoplastic; D002360:Carubicin