title: Response of neoplastic and non-neoplastic cells to a yeast extract.
abstract: PCO, an aqueous-alcoholic extract of the yeast, Saccharomyces cerevisiae, was found to inhibit mitoses of 4 different ascites tumors removed from mice. Carried as established in vitro lines 6 tumors and 4 established lines of non-neoplastic cells could not be inhibited by PCO. Primary cultures (diploid) of mouse embryo tissue cells and granulocytic blast cells from adult mice also could not be mitotically inhibited by PCO.
mesh_terms: D002455:Cell Division / Q000187:drug effects*; D002478:Cells, Cultured; D009374:Neoplasms, Experimental; D010936:Plant Extracts / Q000494:pharmacology*; D011003:Ploidies; D012441:Saccharomyces cerevisiae
chemical_list: D010936:Plant Extracts