Are divided doses of tricyclic antidepressants necessary?
A double blind control comparison on the effects of 50 mg of clomipramine given three times a day and 150 mg of clomipramine in a single bedtime dosage revealed no significant differences in therapeutic efficacy. Patients reported more lightheadedness and dizziness but no differences on other side effects. The theoretical basis was the long biological half-life of such tricyclic antidepressants. Advantages included ease of administration, patient compliance, and timing of sedative effect.
D000275:Adjustment Disorders / Q000188:drug therapy*; D000328:Adult; D002986:Clinical Trials as Topic; D002997:Clomipramine / Q000008:administration & dosage*; D003984:Dibenzazepines / Q000008:administration & dosage*; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales
D003984:Dibenzazepines; D002997:Clomipramine