Effect of morphine analogues on chemotaxis in Escherichia coli.
Pretreatment of Escherichia coli w3110 with levorphanol, a morphine analogue, reduced chemotaxis to serine, aspartic acid and galactose. This decreased chemotaxis was not due to decreased viability or motility. Pretreatment with 1.1 mM-levorphanol for 1 h, followed by washing to remove the drug prior to determination of chemotaxis, inhibited chemotaxis to each of the attractants by at least 80%. Pretreatment with dextrorphan, the enantiomorph of levorphanol, or levallorphan, the N-allyl analogue of levorphanol, resulted in a similar inhibition of chemotaxis. Reversal of the inhibition produced by pretreatment with levorphanol required a period of growth of at least one generation time.
D001224:Aspartic Acid / Q000494:pharmacology; D002633:Chemotaxis / Q000187:drug effects*; D003864:Depression, Chemical; D004926:Escherichia coli / Q000187:drug effects* / Q000502:physiology; D005690:Galactose / Q000494:pharmacology; D007981:Levorphanol / Q000494:pharmacology; D009019:Morphinans / Q000494:pharmacology*; D012694:Serine / Q000494:pharmacology
D009019:Morphinans; D007981:Levorphanol; D001224:Aspartic Acid; D012694:Serine; D005690:Galactose