The mutagenic screening of fourteen imidazo compounds using a modified Ames' test.
Eight imidazo[1,2-alpha] pyrimidine derivatives and six cyclic guanidine derivatives were synthesized in order to study their physiological activity. Mutagenic effects were not detected with any compound in a modified Ames' Salmonella test using TA100, TA98, and TA1537, with or without S9. No inhibition of growth was observed with any test compound. Positive and negative controls behaved as expected.
D000818:Animals; D005821:Genetic Techniques; D006146:Guanidines / Q000494:pharmacology*; D007093:Imidazoles / Q000494:pharmacology*; D008862:Microsomes, Liver / Q000378:metabolism; D009153:Mutagens; D009154:Mutation; D011743:Pyrimidines / Q000494:pharmacology*; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics / Q000378:metabolism
D006146:Guanidines; D007093:Imidazoles; D009153:Mutagens; D011743:Pyrimidines