Disappearance of oxytocin-induced uterine tiredness by treatment with fructose-1,6-diphosphate. Experimental evidence.
Fructose-1,6-diphosphate (FDP) is able to abolish oxytocin induced spastic inertia in rat uterus. The clinical use of FDP is suggested by observation carried out on 30 deliveries with oxytocin induction. The FDP-treated patients (5 g of FDP in 50 ml of water by intravenous infusion) showed a statistically significant decrease of time elapsed between the beginning of uterine inertia and the recovery of uterine contractions (176 +/- 25.4 min) compared to controls (562 +/- 32.5 min).
D000293:Adolescent; D000328:Adult; D000818:Animals; D002986:Clinical Trials as Topic; D005260:Female; D005635:Fructosediphosphates / Q000494:pharmacology*; D006598:Hexosediphosphates / Q000494:pharmacology*; D006801:Humans; D007751:Labor, Induced; D010121:Oxytocin / Q000494:pharmacology*; D011247:Pregnancy; D051381:Rats; D014590:Uterine Contraction / Q000187:drug effects*
D005635:Fructosediphosphates; D006598:Hexosediphosphates; D010121:Oxytocin