New cream vehicle for flurandrenolide.
New methods are now available to help select vehicles for topical corticosteroids. In the development of a new cream vehicle for flurandrenolide, the goal was a cream base with optimal solubility for release of the drug, minimal irritation potential, and no sensitizing preservatives. Vasoconstriction tests make selection much more scientific, and a newer method for such testing is described in detail. Irritation testing then helped determine the vehicle concentration that was least irritating. Final studies included double-blind comparisons with the previous formulation in the treatment of psoriatic patients.
D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004341:Drug Evaluation; D005478:Flurandrenolone / Q000378:metabolism / Q000627:therapeutic use; D006801:Humans; D014677:Pharmaceutical Vehicles; D011565:Psoriasis / Q000188:drug therapy
D014677:Pharmaceutical Vehicles; D005478:Flurandrenolone