title: Factors governing the emergence of resistance to nalidixic acid in treatment of urinary tract infection.
abstract: Cultures of Escherichia coli were exposed to nalidixic acid in an in vitro model in which the conditions of drug-organism interaction resembled those of bacterial cystitis treatment. Results obtained in this way suggested that emergence of bacterial resistance should not be a major problem in treatment of uncomplicated urinary infection; such cases might indeed respond to a less intensive course of treatment than is usual. More prolonged, high-dosage therapy with nalidixic acid may be required for patients with more complicated infections if the risk of failure from the emergence of bacterial resistance is to be minimized.
mesh_terms: D003556:Cystitis / Q000188:drug therapy; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects*; D009268:Nalidixic Acid / Q000494:pharmacology* / Q000627:therapeutic use; D014552:Urinary Tract Infections / Q000188:drug therapy*
chemical_list: D009268:Nalidixic Acid