title: Studies with high-dose methotrexate--historical background.
mesh_terms: D000630:Aminopterin / Q000494:pharmacology; D000818:Animals; D005492:Folic Acid / Q000378:metabolism; D049673:History, 20th Century; D006801:Humans; D002955:Leucovorin / Q000378:metabolism; D007942:Leukemia, Experimental / Q000378:metabolism; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects / Q000266:history / Q000627:therapeutic use*; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy*; D013997:Time Factors
chemical_list: D005492:Folic Acid; D000630:Aminopterin; D002955:Leucovorin; D008727:Methotrexate