Human platelet aggregation induced by prostaglandin endodisulfide.
The effect on human platelet functions of 9,11-dithio analogues of prostaglandin endoperoxide was investigated. Methyl (5Z, 9alpha, 11alpha, 13E, 15S)-9,11-epidithio-15-hydroxyprosta-5,13-dienoate induced platelet aggregation, while the 9beta,11beta-epimer was inactive. The platelet aggregation caused by the 9alpha,11alpha-dithio analogue was associated with serotonin release from platelets, and was inhibited by methyl ester of prostaglandin I2 (prostacyclin) but not by indomethacin.
D001792:Blood Platelets / Q000187:drug effects; D004347:Drug Interactions; D011464:Epoprostenol / Q000494:pharmacology; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects*; D011450:Prostaglandin Endoperoxides, Synthetic / Q000494:pharmacology*; D012701:Serotonin / Q000378:metabolism; D013997:Time Factors
D011450:Prostaglandin Endoperoxides, Synthetic; D012701:Serotonin; D011464:Epoprostenol; D007213:Indomethacin