Mollicellins: mutagenic and antibacterial mycotoxins.
Eight mollicellins (depsidones) were assayed for mutagenicity and antibacterial activity in Salmonella/microsome tests involving histidine reversion and forward mutation to 8-azaguanine resistance. Two of them, mollicellins C and E, which contain a 3-methylbutenoic acid moiety, were mutagenic and bactericidal for Salmonella typhimurium in the absence of microsomes. Mollicellins D and F, each containing a chlorine atom, were bactericidal but not mutagenic. The mutagenic activity was completely abolished and the antibiotic activity was greatly reduced by coincubation with rat liver microsomes.
D000818:Animals; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D001203:Ascomycota / Q000378:metabolism*; D001375:Azaguanine / Q000494:pharmacology; D002597:Chaetomium / Q000378:metabolism*; D055598:Chemical Phenomena; D002621:Chemistry; D004352:Drug Resistance, Microbial; D006639:Histidine / Q000378:metabolism; D008862:Microsomes, Liver / Q000378:metabolism; D009153:Mutagens; D009154:Mutation; D009183:Mycotoxins / Q000096:biosynthesis / Q000494:pharmacology*; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000235:genetics
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D009153:Mutagens; D009183:Mycotoxins; D006639:Histidine; D001375:Azaguanine