Synergy between sulphonamide and trimethoprim in the presence of pus.
Synergy between sulphadiazine and trimethoprim against Escherichia coli has been demonstrated in culture media not containing lysed horse blood despite the presence of pus or a pus extract which inhibited the action of each drug separately. Synergy may therefore be important where pus is present in vivo.
D003470:Culture Media; D004357:Drug Synergism; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D013411:Sulfadiazine / Q000494:pharmacology*; D013492:Suppuration; D014295:Trimethoprim / Q000494:pharmacology*
D003470:Culture Media; D013411:Sulfadiazine; D014295:Trimethoprim