Vasodilation produced by prostacyclin (PGI2) and 9(O)-thiaprostacyclin (PGI2-S) in the canine femoral circulation.
The action of 9(0)-thiaprostacyclin (PGI2-S) was compared with that of prostacyclin (PGI2) and papaverine in the femoral circulation of dogs. PGI2-S, injected into the dog femoral artery in a dose of 0.1 microgram or higher, produced marked vasodilation in the femoral artery without any change in blood pressure. The potentcy of PGI2-S was one tenth that of PGI2, and was a hundred times that of papaverine. The stability of PGI2-S in neutral solution was forty times that of PGI2.
D000818:Animals; D004285:Dogs; D011464:Epoprostenol / Q000494:pharmacology*; D005260:Female; D005269:Femur / Q000098:blood supply; D006207:Half-Life; D008297:Male; D010208:Papaverine / Q000494:pharmacology; D011453:Prostaglandins / Q000494:pharmacology*; D011465:Prostaglandins, Synthetic / Q000494:pharmacology; D012039:Regional Blood Flow / Q000187:drug effects; D014665:Vasodilator Agents
D011453:Prostaglandins; D011465:Prostaglandins, Synthetic; D014665:Vasodilator Agents; D010208:Papaverine; D011464:Epoprostenol