[Comparative study of the effect of ionic and non-ionic surface-active compounds on plasmic membrane of yeast protoplasts].
Lytic effect of some cationic surface-active compounds (SAC) on yeast protoplast plasmic membrane is studied. Comparative analysis of the lytic effect of anionic, cationic and non-ionic SAC is carried out, a correlation between key physico-chemical characteristics of the agents (critical concentration of micellization, hydrophyle-lipophyle balance) and their lytic activity is investigated. A proposition is made on the presence in all biphylic compounds of a hydrophyly gradient, which is due to the effect of hydrophylic group on lipophylic properties of hydrophobic part of the molecule, and possible role of this factor in thelytic effect of biphylic compounds on biological membranes is discussed.
D002462:Cell Membrane / Q000187:drug effects / Q000648:ultrastructure*; D011523:Protoplasts / Q000187:drug effects / Q000648:ultrastructure; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000648:ultrastructure*; D013501:Surface-Active Agents / Q000494:pharmacology*
D013501:Surface-Active Agents
Sravienie deistviia ionnykh i neionnykh poverkhonostno-aktivnykh veshchestv na plazmaticheskuiu mambrany drozhzhevykh protoplastov.