[Exerimental study of enterotoxic activity in some strains of Salmonella typhimurium: observations on the model of ADP-induced platelet aggregation].
In a previous report it has been shown that enterotoxin preparations (cholera and E. Coli) able to activate adenylatecyclase system, abrogated platelet aggregation induced by ADP. In the present study the same experimental model has been applied to some purified filtrates from Salmonella typhimurium strains. Preparations from 986 and TLM (invasive strains causing also fluid secretion) interfere with platelet aggregation, while 1027 strain (invasive but not evoking fluid secretion) didn't show such effect. It has been argued, as Sandefur and Peterson have demonstrated with different experimental models, that the system of platelet aggregation induced by ADP is valid for some strains of Salmonella typhimurium, which act with a mechanism partially involving adenylatecyclase system (i.g. cholera-like).
D000244:Adenosine Diphosphate / Q000494:pharmacology*; D002478:Cells, Cultured; D004768:Enterotoxins / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D012486:Salmonella typhimurium
D004768:Enterotoxins; D000244:Adenosine Diphosphate
Contributo sperimentale allo studio dell'attivita enterotossica in alcuni stipiti di Salmonella typhimurium: osservazioni sul modello dell'aggregazione piastrinica da ADP.