Comutagenic effect of norharman and harman with 2-acetylaminofluorene derivatives.
Norharman enhanced the known mutagenicity of 2-acetylaminofluorene derivatives in the Salmonella test system. The mutagenicities of 2-acetylaminofluorene, 2-aminofluorene, and N-hydroxy-2-acetylaminofluorene were enhanced by norharman only when rat liver microsomal enzymes were added, whereas the mutagenicity of N-acetoxy-2-acetylaminofluorene was increased in the absence of microsomal enzymes. Harman also increased mutagenesis, althouth less so than norharman.
D015073:2-Acetylaminofluorene / Q000494:pharmacology*; D000470:Alkaloids / Q000494:pharmacology*; D002243:Carbolines; D004357:Drug Synergism; D005449:Fluorenes / Q000494:pharmacology*; D006247:Harmine / Q000031:analogs & derivatives / Q000494:pharmacology*; D008862:Microsomes, Liver / Q000378:metabolism; D009153:Mutagens; D012486:Salmonella typhimurium / Q000187:drug effects
D000470:Alkaloids; D002243:Carbolines; D005449:Fluorenes; D009153:Mutagens; D006247:Harmine; C005010:harman; C010262:norharman; D015073:2-Acetylaminofluorene