title: Anti LH and FSH activity of the human urinary antisteroid substance.
abstract: The antisteroid urinary substance was checked out for its effect on LH and FSH under endogenous (castrated animal) and exogenous (administration of releasing hormone-GnRH) stimulation of the rat hypophysis. Administration of this substance partly blocked the castration induced LH and FSH serum increase by 65% and 37% respectively (p less than 0.01) and inhibited the GnRH stimulating effect depressing serum LH by 50% and FSH by 33% (p less than 0.05). In both experiments the LH and FSH content of the hypophysis was not influenced.
mesh_terms: D000818:Animals; D005640:Follicle Stimulating Hormone / Q000037:antagonists & inhibitors*; D007986:Luteinizing Hormone / Q000037:antagonists & inhibitors*; D008297:Male; D010902:Pituitary Gland / Q000187:drug effects; D010906:Pituitary Hormone-Releasing Hormones / Q000494:pharmacology; D051381:Rats; D013256:Steroids / Q000037:antagonists & inhibitors*; D014556:Urine
chemical_list: D010906:Pituitary Hormone-Releasing Hormones; D013256:Steroids; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone