Utility of specific locus systems in higher plants to monitor for mutagens.
Plants possess biological and operational attributes that have encouraged geneticists to use them extensively in the development of fundamental genetic concepts. Attributes such as regenerative plasticity, high fecundity, cultural adaptability, range of ploidy, economics of culture and maintenance of specific populations, and versatility make plant genetic systems prime candidates with which to monitor the environment for mutagens. A specific locus (equivalent to a classical Mendelian gene) controls the development of a phenotypic characteristic. It can also mutate to a new allelic form with a consequentially altered phenotypic characteristic and can be separated by crossing over from adjacent loci that govern other specific phenotypic characteristics. Since various plant species have numerous specific loci, one has a rich array of potential systems from which to select. Specific locus systems in higher plants could be used to assess the mutagenicity of single chemical compounds or combinations of chemical compounds. Depending on the circumstances, seeds and/or seedlings could be used; plants could be grown in situ in either containers or plots to assess the immediate environment for one or more mutagens over an extended period. Since plants are eucaryotes, data from such experiments could serve as one more source of information along with that obtained from a battery of other tests used in the tier system.
D001681:Biological Assay; D002734:Chlorophyll / Q000172:deficiency; D002874:Chromosome Mapping; D001467:Hordeum / Q000187:drug effects / Q000235:genetics; D008722:Methods; D009153:Mutagens / Q000032:analysis* / Q000494:pharmacology; D010944:Plants / Q000187:drug effects / Q000235:genetics*; D013831:Thiamine / Q000378:metabolism; D003313:Zea mays / Q000187:drug effects / Q000235:genetics
D009153:Mutagens; D002734:Chlorophyll; D013831:Thiamine