Uptake of tolbutamide by islets of Langerhans and other tissues.
3-H-tolbutamide was distributed in a volume exceeding the space occupied by 14-C-sucrose in islets as well as in liver, kidney, muscle, and fat. In contrast to previous reports, the findings suggest that tolbutamide is not restricted to the extracellular space of islets.
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D001692:Biological Transport; D005110:Extracellular Space / Q000378:metabolism; D007515:Islets of Langerhans / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D051379:Mice; D009132:Muscles / Q000378:metabolism; D014044:Tolbutamide / Q000378:metabolism*
D014044:Tolbutamide