The effect of 1.5% timolol maleate on intraocular pressure.
A controlled trial was instituted to compare the effect on intraocular pressure of topical administration of timolol maleate with epinephrine hydrochloride. A bottling error by the manufacturer resulted in the placebo bottles containing 1.5% timolol maleate. This drug given twice a day for two weeks significantly reduced intraocular pressure and produced no side effects.
D000287:Administration, Topical; D002986:Clinical Trials as Topic; D003864:Depression, Chemical; D004311:Double-Blind Method; D004837:Epinephrine / Q000008:administration & dosage / Q000494:pharmacology; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D010919:Placebos; D011412:Propanolamines / Q000494:pharmacology*; D013678:Technology, Pharmaceutical; D013999:Timolol / Q000008:administration & dosage / Q000494:pharmacology*
D010919:Placebos; D011412:Propanolamines; D013999:Timolol; D004837:Epinephrine