[Inoculum effects and bacterial resistance (author's transl)].
Massive bacterial populations are frequently involved in infection. Such dense cultures may appear 'resistant' to therapeutically achievable concentrations of some antibacterial agents in vitro, but the implications of this for treatment are not always clear. A better understanding of the mechanisms responsible for inoculum effects may help in assessing their clinical significance and some possible approaches to this goal are described.
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001419:Bacteria / Q000254:growth & development*; D003720:Densitometry; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects; D009268:Nalidixic Acid / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D009268:Nalidixic Acid
Inokulum-effekte und bakterielle Resistenz.