Studies on the modes of action of azaserine in Escherichia coli. Mechanism of resistance to azaserine.
Growth of wildtype Escherichia coli was inhibited by azaserine. There was an inverse relationship between the initial rate of uptake of phenylalanine and the azaserine concentration. Moderately azaserine-resistant mutants exhibited an initial rate that was similar to that of an aroP mutant, but highly azaserine-resistant mutants exhibited little, if any, uptake of phenylalanine. All of the azaserine-resistant organisms tested harboured a mutation in the aroP+ gene. However, resistance to the antibiotic was not due solely to this lesion.
D001224:Aspartic Acid / Q000378:metabolism; D001377:Azaserine / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D009154:Mutation; D010649:Phenylalanine / Q000378:metabolism; D013237:Stereoisomerism; D014161:Transduction, Genetic
D001224:Aspartic Acid; D010649:Phenylalanine; D001377:Azaserine; D005947:Glucose