alpha-1-Antitrypsin immunoreactivity in islet cells of adult human pancreas.
alpha-1-antitrypsin immunoreactivity was demonstrated by immunofluorescence technique in the peripheral islet cells of all ten normal adult human pancreata examined; normal adult human liver was negative. The specificity of the reactions was confirmed by applying various control tests including absorption of the specific antisera with purified alpha-1-antitrypsin, inhibition and blocking tests and by ensuring the monospecificity of the antisera used. The findings suggest that the pancreatic islet may be an additional source of alpha-1-antitrypsin.
D000328:Adult; D000368:Aged; D001344:Autopsy; D005455:Fluorescent Antibody Technique; D006801:Humans; D007515:Islets of Langerhans / Q000276:immunology*; D008099:Liver / Q000276:immunology; D008875:Middle Aged; D010179:Pancreas / Q000276:immunology*; D000515:alpha 1-Antitrypsin / Q000276:immunology*
D000515:alpha 1-Antitrypsin