Activation of the alternative complement pathway by a streptococcal lipoteichoic acid.
A glycerol lipoteichoic acid antigen from Streptococcus pyogenes 1-RP41 was found by rabbit erythrocyte hemolytic assay to activate the alternative complement pathway in human sera. Over a narrow concentration range of the teichoic acid, complement consumption was dose dependent, whereas at higher concentrations of the acid complement consumption could not be detected.
D000942:Antigens, Bacterial / Q000276:immunology*; D003167:Complement Activation; D003170:Complement Pathway, Alternative; D003165:Complement System Proteins / Q000378:metabolism; D008070:Lipopolysaccharides; D010712:Phosphatidic Acids / Q000276:immunology*; D013297:Streptococcus pyogenes / Q000276:immunology*; D013682:Teichoic Acids / Q000276:immunology*
D000942:Antigens, Bacterial; D008070:Lipopolysaccharides; D010712:Phosphatidic Acids; D013682:Teichoic Acids; C009900:lipoteichoic acid; D003165:Complement System Proteins