Use of cell cultures as an indicator of pathogenicity of free-living amoebae.
Results comparing the time needed for the development of cytopathic effects in cell cultures with that needed to cause death in mice using inocula of Naegleria and Acanthamoeba are presented. The significance of the source and concentration of the inocula is demonstrated. The use of cell cultures as an indicator of the pathogenicity of free-living amoebae is discussed.
D000656:Amoeba / Q000472:pathogenicity*; D000818:Animals; D002460:Cell Line; D051379:Mice; D008828:Microbiological Techniques; D008855:Microscopy, Electron, Scanning; D013997:Time Factors; D014774:Virulence