Tamm-Horsfall protein in the glomerular capsular space.
Tamm-Horsfall protein was detected within the capsular space by immunofluorescence in 7 of 72 consecutive patients on whom renal immunopathological studies were performed. Three patients showed prominent aggregates or crescentic collections affecting 30-50% glomeruli; the remaining four patients showed smaller aggregates between lobules. All patients showed pathological evidence of tubulointerstitial disease. It is suggested that Tamm-Horsfall protein in the capsular space is a sign of intratubular urinary backflow and that Tamm-Horsfall antiserum is a useful addition to the reagents used in the immunofluorescence study of renal biopsies.
D000328:Adult; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007674:Kidney Diseases / Q000473:pathology; D007678:Kidney Glomerulus / Q000378:metabolism* / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D009088:Mucoproteins / Q000378:metabolism*
D009088:Mucoproteins