The role of the corpus striatum in neuroleptic- and narcotic-induced catalepsy.
Lesion experiments (in the rat) were designed to elucidate the function of the corpus striatum in neuroleptic- and narcotic-induced catalepsy, respectively. Bilateral lesions of the corpus striatum were observed to attenuate neuroleptic (CPZ)-induced catalepsy. However, analogous lesions of the corpus striatum potentiated narcotic (morphine)-induced catalepsy. These results suggests that (a) the corpus striatum may be a primary site of action of neuroleptic drugs (such as CPZ) in the production of catalepsy, and (b) narcotic (morphine)-induced catalepsy may not be exclusively mediated by the corpus striatum.
D000818:Animals; D002375:Catalepsy / Q000139:chemically induced* / Q000503:physiopathology; D002746:Chlorpromazine / Q000494:pharmacology*; D003342:Corpus Striatum / Q000502:physiology*; D006801:Humans; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D051381:Rats; D013238:Stereotaxic Techniques
D009020:Morphine; D002746:Chlorpromazine