Effects of apomorphine and apomorphine-L-dopa-carbidopa on alcohol post-intoxication symptoms.
In a randomised double-blind clinical trial on 58 gamma-alcoholics, the effect of apomorphine given orally in individual subemetic doses was compared with apomorphine-L-dopa-carbidopa and with placebo. No positive effects of treatment with apomorphine, or with the combination apomorphine-L-dopa-carbidopa, on alcohol consumption or post-intoxication symptoms could be demonstrated. In the group which received the combination apomorphine-L-dopa-carbidopa, the post-intoxication symptoms lasted significantly longer than in the other two groups.
D000328:Adult; D000368:Aged; D000435:Alcoholic Intoxication / Q000150:complications / Q000188:drug therapy*; D000437:Alcoholism / Q000150:complications; D001058:Apomorphine / Q000627:therapeutic use*; D002230:Carbidopa / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D006801:Humans; D006834:Hydrazines / Q000627:therapeutic use*; D007980:Levodopa / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged
D006834:Hydrazines; D007980:Levodopa; D002230:Carbidopa; D001058:Apomorphine