[State of the islands of Langerhans in various animal species after administration of 8-(arensulfonylamino)-quinolines].
The action of 8-(arensulfonylamino)-quinolines on the insular tissue of the pancreas was studied in frogs, pigeons, mice, golden hamsters, rats, rabbits, cats and dogs. There eas a decrease of zinc content in the Langerhans islets at the earliest stages after injection of the drug. Other histochemical components and histostrucutre of the islets changed with the more pronounced effect of the drug. Permanent diabetes with characteristic morphological picture of the pancreas developed in rabbits only. A possible action of chelating factors on human Langerhans islets is suggested on the basis of comparative pathological study.
D000634:Aminoquinolines / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D001001:Anura; D002415:Cats; D010856:Columbidae; D006224:Cricetinae; D004285:Dogs; D007515:Islets of Langerhans / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008647:Mesocricetus; D051379:Mice; D051381:Rats; D013449:Sulfonamides / Q000008:administration & dosage / Q000494:pharmacology / Q000633:toxicity; D015032:Zinc / Q000172:deficiency / Q000378:metabolism
D000634:Aminoquinolines; D013449:Sulfonamides; D015032:Zinc
Sostoianie ostrovkov Langergansa u zhivotnykh raznykh vidov pri vvedenii 8-(arensul'fonilamino)-khinolinov.