The leukemic phase of histiocytic lymphoma. Histologic, cytologic, cytochemical, ultrastructural, immunologic and cytogenetic observations in a case.
A case of histiocytic lymphoma that progressed to a leukemic phase was studied by various methods. Although the cells were found to bear a superficial morphologic resemblance to histiocytes, they more closely resembled transformed lymphocytes. Immunologic markers strongly supported a B-lymphoid origin in this case, while cytogenetic analysis indicated a large number of consistent chromosomal rearrangements, including a translocation involving chromosomes Nos. 8 and 14 which has been previously reported to occur primarily in Burkitt's lymphoma.
D001402:B-Lymphocytes / Q000648:ultrastructure; D002869:Chromosome Aberrations; D002901:Chromosomes, Human, 13-15; D002906:Chromosomes, Human, 6-12 and X; D006644:Histiocytes / Q000648:ultrastructure; D006801:Humans; D007938:Leukemia / Q000276:immunology / Q000648:ultrastructure; D016403:Lymphoma, Large B-Cell, Diffuse / Q000276:immunology / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D013736:Testicular Neoplasms / Q000276:immunology / Q000648:ultrastructure