title: Single-dose tetracycline therapy for shigellosis in adults.
abstract: Forty-two adults who had Shigella isolated from stool (26 symptomatic, 16 asymptomatic) received a single oral dose of tetracycline hydrochloride (2.5 g). Minimal inhibitory concentrations of the 42 isolates demonstrated that 41% were sensitive to tetracycline. Sixteen of 18 patients with diarrhea who had tetracycline-resistant Shigella and all eight patients with diarrhea who had tetracycline-sensitive Shigella were clinical well and had Shigella-negative stools 48 hours after therapy. Fifteen of 16 asymptomatic patients demonstrated clearing of Shigella from stool within 48 hours of therapy. Single-dose tetracycline therapy is effective in the treatment of Shigella regardless of clinical expression of illness or in vitro sensitive of the organism.
mesh_terms: D000328:Adult; D000367:Age Factors; D004352:Drug Resistance, Microbial; D004405:Dysentery, Bacillary / Q000188:drug therapy*; D005243:Feces / Q000382:microbiology; D006801:Humans; D012762:Shigella dysenteriae / Q000187:drug effects / Q000302:isolation & purification; D013752:Tetracycline / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D013752:Tetracycline