Antimycotic denture adhesive in treatment of denture stomatitis.
The mycologic findings of Candida albicans or culturally similar yeasts in 70% of the subject sample is consistent with those of other researchers. It is, however, only one of several etiologic factors requiring concomitant study to obtain meaningful results. Use of an antimycotic denture adhesive did not prove to be effective in the treatment of denture stomatitis. Although in the trial it appeared that marginally better results were obtained with the amphotericin medicated adhesive, this could not be substantiated statistically. On retrospective testing in the laboratory, both medicated and placebo materials were found to have an inhibiting effect on the growth of C. albicans. However, it was considered that the beneficial effects noted were probably due to the adhesive and lubricant effects of the test materials in reducing denture trauma in function.
D000269:Adhesives / Q000627:therapeutic use*; D000666:Amphotericin B / Q000627:therapeutic use*; D002176:Candida albicans / Q000166:cytology; D002986:Clinical Trials as Topic; D003781:Denture Retention; D003824:Denture, Complete / Q000009:adverse effects*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D009061:Mouth Mucosa / Q000382:microbiology / Q000473:pathology; D010781:Photography / Q000379:methods; D010919:Placebos; D011208:Powders; D013280:Stomatitis / Q000188:drug therapy*; D013282:Stomatitis, Denture / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology
D000269:Adhesives; D010919:Placebos; D011208:Powders; D000666:Amphotericin B