title: Studies on the role of serotonin in gastric pepsin secretion.
abstract: The effect of serotonin depletion and replacement on histamine stimulated pepsin secretion was evaluated from Heidenhain pouches of dogs. Serotonin depletion by reserpine or antagonism by l-methyl-d-lysergic acid butanolamide significantly reduced histamine stimulated pepsin secretion. Serotonin replacement by 5-hydroxytryptophan elevated pepsin secretion, despite the prior depletion by reserpine. The data suggest that serotonin is a stimulator of histamine stimulated pepsin secretion in denervated gastric pouches in dogs.
mesh_terms: D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000818:Animals; D004285:Dogs; D005260:Female; D005750:Gastric Juice / Q000187:drug effects / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism; D006632:Histamine / Q000494:pharmacology; D008784:Methysergide / Q000494:pharmacology*; D010434:Pepsin A / Q000378:metabolism*; D012701:Serotonin / Q000494:pharmacology / Q000502:physiology*; D012702:Serotonin Antagonists; D013270:Stomach / Q000201:enzymology / Q000502:physiology
chemical_list: D012702:Serotonin Antagonists; D012701:Serotonin; D006632:Histamine; D006916:5-Hydroxytryptophan; D010434:Pepsin A; D008784:Methysergide