Sequelae of caffeine treatment in preterm infants with apnea.
Growth, neurologic, and ophthalmologic assessments were done in 21 low-birth-weight infants given caffeine for neonatal apnea and in 21 matched control infants. Caffeine significantly decreased the need for and the duration of mechanical ventilation. No difference in growth and development was noted between the control and caffeine-treated infants. A high incidence of cicatricial retrolental fibroplasia was observed in both control (10/21) and caffeine-treated infants (7/18).
D001049:Apnea / Q000150:complications / Q000188:drug therapy*; D002110:Caffeine / Q000009:adverse effects / Q000627:therapeutic use*; D002657:Child Development / Q000187:drug effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000188:drug therapy*; D007385:Intermittent Positive-Pressure Ventilation / Q000009:adverse effects; D008297:Male; D009422:Nervous System Diseases / Q000150:complications; D012178:Retinopathy of Prematurity / Q000209:etiology
D002110:Caffeine