Protection against endotoxin shock and impaired glucose homeostasis with ATP.
ATP-Mg++ (10 mumoles/100 g, iv) increased the LD50 for Salmonella enteritidis lipopolysaccharide (endotoxin) in male Holtzman rats (300 +/- 10 g) from 1.3 to 6.0 mg/rat. While endotoxin at 3 mg/rat iv 5 hr previously induced hypoglycemia to 12 +/- 4 mg/dl, ATP cotreatment blunted the hypoglycemia; i.e., plasma glucose values were 78 +/- 6 mg/dl. ATP treatment prevented the depression in gluconeogenesis induced by endotoxin as evaluated in vivo by the conversion of 14C-alanine to 14C-glucose. ATP treatment also reduced the hypercatabolism of U-14 C-glucose to 14CO2 in vivo and by epididymal fat pads in vitro. A role for ATP in preventing disruption of glucose homeostasis and development of endotoxin shock via counteracting insulin is suggested.
D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D004731:Endotoxins / Q000633:toxicity; D005943:Gluconeogenesis / Q000187:drug effects; D005947:Glucose / Q000378:metabolism*; D006706:Homeostasis / Q000187:drug effects; D007928:Lethal Dose 50; D008297:Male; D051381:Rats; D012477:Salmonella enteritidis; D012772:Shock, Septic / Q000378:metabolism*
D004731:Endotoxins; D000255:Adenosine Triphosphate; D005947:Glucose