Bone marrow transplantation after lethal chemotherapy in "nude" mice.
Isogenic bone marrow transplantation was performed in "nude" and normal C3H mice after lethal doses of dimethylmyleran (DMM), meso-DMM, and (+/-) DMM were given. Nude mice were not more sensitive to DMM or its isomers than normal mice. With adequate cell doses in the range of 3 X 10(6) to 30 X 10(6) bone marrow cells or 10 X 10(6) to 30 X 10(6) spleen cels, the survival rate after lethal chemotherapy was not significantly different between nude mice reconstituted with a graft from nude donors and normal mice reconstituted with a graft from normal donors. Only with suboptimal cell dose (1 X 10(6) bone marrow cells) was survival superior in normal mice. Thinsic factor. Nude mice accepted also bone marrow grafts from allogeneic nude donors.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D016026:Bone Marrow Transplantation; D002066:Busulfan / Q000031:analogs & derivatives / Q000506:poisoning / Q000627:therapeutic use*; D051379:Mice; D008809:Mice, Inbred C3H; D008819:Mice, Nude / Q000276:immunology*; D013045:Species Specificity; D013154:Spleen / Q000637:transplantation; D014184:Transplantation, Homologous; D014185:Transplantation, Isogeneic
D002066:Busulfan