Analgesic activity of ibuprofen (Motrin) in postoperative oral surgical pain.
The effectiveness of 400 and 800 mg. of ibuprofen was compared to that of 650 mg. of aspirin, 65 mg. of propoxyphene HCl, and placebo in 510 patients experiencing pain subsequent to oral surgical procedures. In double-blind study, patients were randomly assigned to one of five experimental groups and instructed to report the intensity of pain (complete, partial, or none) over a 3-hour period of evaluation. Ibuprofen, at both doses, was shown to be more effective for both degree and duration of relief from pain.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000700:Analgesics; D001241:Aspirin / Q000008:administration & dosage / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D011431:Dextropropoxyphene / Q000008:administration & dosage / Q000627:therapeutic use; D004311:Double-Blind Method; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009055:Mouth / Q000601:surgery*; D010149:Postoperative Pain / Q000188:drug therapy*; D010919:Placebos
D000700:Analgesics; D010919:Placebos; D001241:Aspirin; D011431:Dextropropoxyphene; D007052:Ibuprofen