Strain difference of delayed-type hypersensitivity to BCG and its genetic control in mice.
Delayed-type hypersensitivity to BCG was remarkably different in two inbred strains of mice, SWM/Ms and C3H/He, when measured by the spleen index, the disappearance of peritoneal macrophage, or the footpad reaction. High responsiveness in the SWM/Ms strain appeared to be dominant over low responsiveness in the C3H/He strain. Results of the footpad reaction test if F1, F2, and backcross hybrids of these two strains of mice suggested that the delayed-type hypersensitivity was mainly controlled by a gene which was transmitted under Mendel's laws and was possibly non-H-2 linked. The spleen cells and their nylon wool nonadherent fraction from BCG-infected C3H/He mice were not reactive to purified protein derivative in vitro, whereas both the spleen cells and the nylon wool nonadherent fraction from BCG-infected SWM/Ms mice reacted well to purified protein derivative. Possible mechanisms of the different responses in the delayed-type hypersensitivity to BCG were discussed.
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology*; D001500:BCG Vaccine; D005799:Genes, Dominant; D008040:Genetic Linkage; D006968:Hypersensitivity, Delayed; D008213:Lymphocyte Activation; D051379:Mice; D008809:Mice, Inbred C3H; D008815:Mice, Inbred Strains; D009163:Mycobacterium bovis / Q000276:immunology*; D013045:Species Specificity
D000942:Antigens, Bacterial; D001500:BCG Vaccine