Orotic acid excretion in some wild-type strains of Escherichia coli K-12.
During rapid growth,  the excretion of pyrimidines, predominantly uracil, is a common phenomenon in procaryotes and eucaryotes. In Escherichia coli, some K-12 strains excrete orotic acid and not uracil. This is caused by a mutation in the pyrF gene.
D004926:Escherichia coli / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D005796:Genes; D009154:Mutation; D009963:Orotic Acid / Q000378:metabolism*; D009964:Orotidine-5'-Phosphate Decarboxylase / Q000235:genetics; D014498:Uracil / Q000378:metabolism
D014498:Uracil; D009963:Orotic Acid; D009964:Orotidine-5'-Phosphate Decarboxylase