Mutagenicity of some commercially available nitro compounds for Salmonella typhimurium.
Benzoyl chloride and 53 commercially available aromatic heterocyclic and aliphatic nitro compounds were tested for mutagenicity in Salmonella typhimurium TA98 and TA100. 34 of 53 nitro compounds (64%) were mutagenic, 4 in TA100 only, 15 in TA98 only, and 15 in both strains. 13 of the heterocyclic derivatives of pyridine, indole, indazole, quinoline, and benzimidazole were mutagenic. 21 of 34 mutagenic nitro compounds were bactericidal. Nitromethane was the only aliphatic tested and was not mutagenic. Benzoyl chloride, a human carcinogen, was mutagenic for TA98.
D000900:Anti-Bacterial Agents; D005821:Genetic Techniques; D009153:Mutagens; D009574:Nitro Compounds / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000187:drug effects
D000900:Anti-Bacterial Agents; D009153:Mutagens; D009574:Nitro Compounds