Tumour angiogenesis factor (TAF) and its neutralisation by a xenogeneic antiserum.
Tumour angiogenesis factor (TAF) has been extracted from a variety of animal and human tumours. Its ability to induce neovascularization in two bioassays, viz. rat air-sac and chick chorioallantoic membrane, is demonstrated. Similar extracts from normal tissues fail to induce angiogenesis. TAF extracts have been used to raise a xenogeneic antiserum, the specificity of which was investigated using classical immunological methods. Its ability to neutralize the biological activity of TAF using the two in vivo assays, was also demonstrated.
D000482:Allantois / Q000098:blood supply; D043925:Angiogenesis Inducing Agents / Q000032:analysis / Q000037:antagonists & inhibitors*; D000818:Animals; D002645:Chickens; D002823:Chorion / Q000098:blood supply; D005205:Fascia / Q000098:blood supply; D005455:Fluorescent Antibody Technique; D006131:Growth Inhibitors; D006801:Humans; D007106:Immune Sera; D007122:Immunoelectrophoresis; D009369:Neoplasms / Q000098:blood supply* / Q000276:immunology; D009374:Neoplasms, Experimental / Q000098:blood supply / Q000276:immunology; D051381:Rats; D012867:Skin / Q000098:blood supply
D043925:Angiogenesis Inducing Agents; D006131:Growth Inhibitors; D007106:Immune Sera