Diabetes mellitus, islet-cell antibodies, and HLA-B8 in a patient with systemic lupus erythematosus.
Evidence that autoimmune mechanisms may provide a possible explanation for the occurrence of some types of diabetes mellitus has included the clinical association of diabetes with other autoimmune conditions and the serologic demonstration of organ-specific antibodies. This article reports the case of a patient with systemic lupus erythematosus accompanied by diabetes and the presence of antibodies to pancreatic islet cells. This represents further evidence that autoimmune activity may play a role in the etiology of diabetes mellitus, which is especially interesting in light of recent HLA antigen studies that show a possible genetic link between the two diseases.
D000092:Acetohexamide / Q000627:therapeutic use; D000293:Adolescent; D001323:Autoantibodies / Q000032:analysis*; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy / Q000235:genetics / Q000276:immunology*; D005260:Female; D005455:Fluorescent Antibody Technique; D006680:HLA Antigens / Q000032:analysis*; D006801:Humans; D007515:Islets of Langerhans / Q000276:immunology*; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy / Q000235:genetics / Q000276:immunology*; D011241:Prednisone / Q000627:therapeutic use
D001323:Autoantibodies; D006680:HLA Antigens; D000092:Acetohexamide; D011241:Prednisone