title: Catecholamine-induced changes in plasma glucose, glucagon and insulin in rabbits: effects of somatostatin.
abstract: The present study was conducted to determine if glucagon release is involved in the hyperglycemic response to epinephrine and isoproterenol in the fasted and fed, unanesthetized rabbit. Epinephrine produced dose-related increases in plasma glucose and glucagon levels in fed and fasted rabbits whereas isoprotereol produced modest hyperglycemia without hyperglucagonemia. Infusion of somatostatin suppressed epinephrine-induced glucagon release and this was correlated with a 50% reduction in the hyperglycemic response. These data suggest that epinephrine-induced glucagon release is the primary reason for the difference in hyperglycemic activity between epinephrine and isoproterenol in the unanesthetized rabbit.
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000494:pharmacology*; D005215:Fasting; D005934:Glucagon / Q000097:blood*; D013007:Growth Hormone-Releasing Hormone / Q000494:pharmacology*; D007328:Insulin / Q000097:blood*; D007545:Isoproterenol / Q000494:pharmacology*; D011817:Rabbits
chemical_list: D001786:Blood Glucose; D007328:Insulin; D005934:Glucagon; D013007:Growth Hormone-Releasing Hormone; D007545:Isoproterenol; D004837:Epinephrine