title: Coronary capillary permeability and tissue volumes for sucrose and water in dogs: a comparison of bolus and constant infusion multiple-indicator methods.
abstract: This study was undertaken to determine the accuracy with which heart interstitial and water volumes could be determined from multiple-indicator dilution experiments on the coronary circulation in open-chest dog preparations. Sucrose permeability by extraction calculations was found to average 0.26 +/- 0.02 cm3 . (min . g tissue)-1. The extravascular sucrose volume averaged 0.15 cm3 . g-1 tissue by both multiple-indicator and post-mortem methods. Indicator-dilution tritiated water curves labelled 85% of the post-mortem water content.
mesh_terms: D000818:Animals; D001834:Body Water / Q000032:analysis*; D002199:Capillary Permeability; D003326:Coronary Circulation; D004285:Dogs; D005110:Extracellular Space / Q000032:analysis; D007201:Indicator Dilution Techniques; D009206:Myocardium / Q000032:analysis*; D013395:Sucrose / Q000032:analysis*
chemical_list: D013395:Sucrose