[Specific mutagenic effectiveness of 1,4-bis-diazoacetylbutane in relation to individual genes].
A selective effect of 1,4-bis-diazoacetylbutane (DAB) with respect to individual genes is observed when studying its mutagenic action on bacterial strains. Escherichia coli and Salmonella typhimurium. The frequency of mutations to thr+ exceeded in three orders the background of spontaneous variability for this marker. No induced mutations to trp+ and his+ leu+, which might be the result of transition, transversions, suppressor mutations and frame shift mutations, were detected. Mutagenic effect of DAB is due to the functioning of the gene uvr+. Several hypotheses are proposed on possible mechanism of the specific effect of DAB with respect to individual genes.
D000272:Adipates / Q000494:pharmacology*; D000483:Alleles; D001391:Azo Compounds / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics; D005796:Genes / Q000187:drug effects*; D006639:Histidine / Q000235:genetics; D007930:Leucine / Q000235:genetics; D009153:Mutagens; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D013912:Threonine / Q000235:genetics; D014364:Tryptophan / Q000235:genetics
D000272:Adipates; D001391:Azo Compounds; D009153:Mutagens; D013912:Threonine; D006639:Histidine; D014364:Tryptophan; D007930:Leucine
Spetsificheskaia mutagennaia éffektivnost' 1,4-bis-diazoatsetilbutana v otnoshenii individual'nykh genov.