title: Role of glutathione in reversing the deleterious effects of a thiol-oxidizing agent in Escherichia coli.
abstract: Diamide was found to be much less specific for the oxidation of glutathione in vivo in Escherichia coli than had been previously assumed. In vivo, only a slight alteration of the ratio of reduced to oxidized glutathione was found, whereas a significant amount of glutathione was found in the form of mixed disulfide with proteins. This latter occurrence was postulated as being responsible for the bacteriostatic effect of diamide.
mesh_terms: D001391:Azo Compounds / Q000494:pharmacology*; D003958:Diamide / Q000378:metabolism / Q000494:pharmacology*; D004220:Disulfides / Q000378:metabolism; D004926:Escherichia coli / Q000187:drug effects* / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism*; D013438:Sulfhydryl Compounds / Q000378:metabolism
chemical_list: D001391:Azo Compounds; D004220:Disulfides; D013438:Sulfhydryl Compounds; D003958:Diamide; D005978:Glutathione