[Malignant lymphopathy in a patient suffering from acute disseminated lupus erythematosus (author's transl)].
The authors report a case of acute disseminated lupus erythematosus in a 55 years old patient, receiving small doses of corticosteroids, progressing over three years. During an acute exacerbation of the disease, the development of a cervical adenopathy led to a biopsy. Histological examination revealed a lymphocytic type malignant proliferation (centro-follicular lymphoma). This case is compared with findings reported in the literature and leads to a discussion of the relationship between ADLE and malignant disorders due to a disturbance of immune control mechanisms and the possible role of immune-depressant therapy in their onset.
D002699:Chlorambucil / Q000627:therapeutic use; D005727:Ganglia, Spinal / Q000473:pathology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000188:drug therapy; D008224:Lymphoma, Follicular / Q000150:complications* / Q000209:etiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use
D002699:Chlorambucil; D011239:Prednisolone
Lymphopathie maligne chez un malade ayant un lupus érythémateux aigu disséminé.