Effect of intravenous infusion of somatostatin on gastric, pancreatic and biliary secretion in the rat.
The effect of somatostatin (GH-RIH) on gastric, pancreatic and biliary secretion was examined in the anesthetized rats. Intravenous infusion of the hormone, in graded doses ranging from 1 to 16 microgram/kg/hr, produced a dose dependent inhibition of pentagastrin, 1.5 microgram/kg/hr, induced acid secretion, reaching about 54% of control level at the dose of 16 microgram/kg/hr. Somatostatin, 4, 16 and 64 microgram/kg/hr, inhibited the pancreatic juice volume stimulated by intravenous injection of secretin, 1 u/kg, as a bolus. Somatostastin, 2, 8, 32 and 128 microgram/kg/30 min, did not change the bile flow rate in control period. Somatostatin may play a physiological role in the regulation of the secretory process of the stomach and pancreas.
D000818:Animals; D001646:Bile / Q000378:metabolism*; D003864:Depression, Chemical; D005260:Female; D005750:Gastric Juice / Q000378:metabolism*; D007263:Infusions, Parenteral; D010179:Pancreas / Q000187:drug effects; D010189:Pancreatic Juice / Q000378:metabolism*; D010418:Pentagastrin / Q000378:metabolism; D010434:Pepsin A / Q000378:metabolism; D051381:Rats; D013004:Somatostatin / Q000008:administration & dosage*; D013270:Stomach / Q000187:drug effects
D013004:Somatostatin; D010434:Pepsin A; D010418:Pentagastrin