[Cerebrospinal fluid distribution of metampicillin (author's transl)].
In order to avoid other antibiotics which interfere with plasma and CSF level determination of a given antibiotic the authors use a chemical method of established specificity. 15 patients presenting with purulent meningitis were given a standard daily dose of metampicillin and divided into 3 groups of 5. On days 2, 4 and 6 after onset of disease plasma and CSF specimens were taken at respectively 1, 2 or 4 hours following metampicillin I.V. injection according to patient group. All patients were cured between days 7 and 21 of therapy. Tolerance was good.


RESULTS
--there was no correlation between dose injected and plasma level of drug,--CSF distribution of metampicillin was good and stayed identical throughout the disease period,--peak CSF drug level was delayed as compared to plasma level, occurring more than 4 hours after I.V. injection of metampicillin.
D000667:Ampicillin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000134:cerebrospinal fluid; D001812:Blood-Brain Barrier; D006801:Humans; D007275:Injections, Intravenous; D007700:Kinetics; D008581:Meningitis / Q000188:drug therapy*; D008722:Methods; D013997:Time Factors
D000667:Ampicillin; C005195:methampicillin
Cinétique intra-rachidienne de la métampicilline.