Amelioration of bronchopulmonary dysplasia after vitamin E administration. A preliminary report.
We studied the effect of vitamin E on the development of bronchopulmonary dysplasis in neonates with respiratory-distress syndrome. Twenty infants received vitamin E administered intramuscularly during the acute phase of the syndrome, and 20 infants served as controls. Administration of vitamin E significantly increased the serum vitamin E concentration. Nine vitamin-treated and 13 control patients required supplemental oxygen for longer than 250 hours; all were treated with positive-pressure ventilation and endotracheal continuous distending airway pressure. Six of those 13 controls had x-ray changes consistent with bronchopulmonary dysplasia, and four died. None of the nine vitamin-treated patients had changes characteristic of bronchopulmonary dysplasia (P = 0.046), and all survived. Administration of vitamin E during the acute phase of the respiratory-distress syndrome appears to modify the development of bronchopulmonary dysplasis.
D001982:Bronchial Diseases / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000517:prevention & control*; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000517:prevention & control*; D007273:Injections, Intramuscular; D008171:Lung Diseases / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000517:prevention & control*; D008297:Male; D010100:Oxygen / Q000633:toxicity; D010102:Oxygen Inhalation Therapy / Q000009:adverse effects*; D011859:Radiography; D012121:Respiration, Artificial; D012127:Respiratory Distress Syndrome, Newborn / Q000150:complications* / Q000628:therapy; D014810:Vitamin E / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*
D014810:Vitamin E; D010100:Oxygen