[Effect of Complamin on the intrahepatic blood flow and pancreatic secretion of enzymes in diabetes mellitus].
Complamine (xanthinol-nicotinate) injected intravenously in a dose of 300 mg caused in patients with diabetes mellitus a significant, although short-lived improvement of the indices of intrahepatic circulation (by the rheohepatographic criteria). By itself complamine failed to influence the pancreatic secretion of amylase, lipase, and trypsin, but regularly intensified the stimulating action of pancreosimine on the pancreatic secretion of the enzymes in the patients with diabetes. In addition to the known influence of complamine on the circulation in the lower limbs of the patients with diabetes mellitus, information presented in the given work widened the circle of indications to the therapeutic use of complamine in patients with diabetes mellitus with disturbances of intrahepatic hemodynamics and the enzyme-secretory insufficiency of the pancreas. Complamine should be administered after meals at the period of the greatest release of the endogenous pancreosimine, for the intensification of the pancreatic enzymes secretion.
D000328:Adult; D001783:Blood Flow Velocity; D002766:Cholecystokinin / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003920:Diabetes Mellitus / Q000188:drug therapy*; D004341:Drug Evaluation; D004357:Drug Synergism; D006801:Humans; D008099:Liver / Q000098:blood supply* / Q000187:drug effects; D008875:Middle Aged; D010179:Pancreas / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D013806:Theophylline / Q000031:analogs & derivatives*; D013997:Time Factors; D014971:Xanthinol Niacinate / Q000627:therapeutic use*
D014971:Xanthinol Niacinate; D002766:Cholecystokinin; D013806:Theophylline
Vliianie komplamina na vnutripechenochnyi krovotok i pankreaticheskuiu sekretsiiu fermentov u bol'nykh sakharnym diabetom.