Myelotoxicity of methotrexate in animals with pyogenic infection.
Rats stimulated into prolonged increased neutrophil production by the induction of a unilateral pyo-hydronephrosis showed consistent profound neutropenia when methotrexate (MTX) was given during the first 2 d of infection. Thereafter greater neutropenia than that observed in non-infected rats was only observed in occasional animals. There was a significant correlation between the degree of neutropenia induced by MTX and the day after MTX upon which this occurred. The main target for myelotoxicity by MTX appears to be the myelocyte. Its precursors seem relatively insensitive.
D000380:Agranulocytosis / Q000139:chemically induced*; D000818:Animals; D004927:Escherichia coli Infections / Q000097:blood*; D005260:Female; D006869:Hydronephrosis / Q000209:etiology; D007958:Leukocyte Count; D008727:Methotrexate / Q000633:toxicity*; D009503:Neutropenia / Q000139:chemically induced* / Q000150:complications; D051381:Rats; D013997:Time Factors
D008727:Methotrexate