Transplantation unresponsiveness induced by allogeneic serum in combination with allogeneic cells and hydrocortisone in adult rats.
Attempts were made to optimize the treatment by using serum as antigen source for the induction of transplantation unresponsiveness in adult rats. With the scheme described it was possible to induce by serum injections the transplantation unresponsiveness not only in the week non-H-1, but also in the strong H-1 antigenic difference; this shows that there is no essential difference in the presence of H-1 and non-H-1 antigens in the serum. Allogeneic serum in conjunction with allogeneic cells was most effective in the non-H-1-different strain combination, whereas the combined treatment consisting of allogeneic serum, allogeneic cells, and hydrocortisone produced the longest skin graft survival in the H-1 antigenic difference. Some paradoxical results are discussed.
D000818:Animals; D000941:Antigens; D001769:Blood / Q000276:immunology; D001854:Bone Marrow Cells; D006085:Graft Survival; D006648:Histocompatibility; D006854:Hydrocortisone / Q000627:therapeutic use; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew; D011919:Rats, Inbred Strains; D016038:Skin Transplantation; D014184:Transplantation, Homologous
D000941:Antigens; D006854:Hydrocortisone