title: Tinidazole and metronidazole in hepatic amoebiasis.
abstract: The efficacy of metronidazole and tinidazole has been compared in 31 patients with hepatic amoebiasis. Only those with unequivocal clinical, radiological and laboratory evidence of hepatic amoebiasis were included; diagnostic and therapeutic aspiration was performed where necessary. 15 patients received metronidazole and 16 tinidazole, in random order. The 2 groups were comparable. Both drugs were given orally in a single daily dose of 2g for a minimum of 3 days, with treatment extended if considered clinically advisable. 12 of 15 patients (80%) were cured with metronidazole given for an average period of 7 days (range 4 to 14 days). 15 of 16 patients (93.8%) given tinidazole were cured and the mean duration of treatment was 4 days (range 3 to 6 days). There were fewer side-effects with tinidazole. In this study of hepatic amoebiasis in Bangladesh, tinidazole was found to be superior to metronidazole in overall efficacy because a shorter course of treatment was necessary and it caused fewer side-effects.
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008101:Liver Abscess, Amebic / Q000188:drug therapy*; D008297:Male; D008795:Metronidazole / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D009593:Nitroimidazoles / Q000627:therapeutic use*; D014011:Tinidazole / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D009593:Nitroimidazoles; D014011:Tinidazole; D008795:Metronidazole