title: [Biosynthesis and structure of the yeast fatty acid synthetase complex].
abstract: Genetic as well as biochemical data suggest that the yeast fatty-acid synthetase complex has an (AB)6 protein structure where A and B represent multifunctional polypeptide chains with molecular weights of 185000 and 180000 daltons, respectively. Subunit A contains at least 3 and subunit B4 of the 8 known biochemical functions of the multienzyme complex. It is concluded that this complex structure has evolved from the corresponding prokaryotic system of monofunctional enzymes due to a selective advantage regarding the biosynthesis and assembly of the complex components.
mesh_terms: D064429:Fatty Acid Synthases / Q000096:biosynthesis*; D009154:Mutation; D055503:Protein Multimerization; D012441:Saccharomyces cerevisiae / Q000201:enzymology*
chemical_list: D064429:Fatty Acid Synthases
vernacular_title: Biosynthese und Struktur des Fettsäuresynthetase-Komplexes der Hefe.