Biliary sludging following liver transplantation in man.
Following orthotopic liver transplantation in man biliary, obstruction has been produced by masses of inspissated bile--biliary "sludge." Bile studies in two groups of patients following transplantation show that bile is lithogenic in the early postoperative period but that reestablishment of the entero-hepatic circulation of bile salts corrects this. Such changes, however, do not appear to be important in sludge formation and biochemical and histological studies of bile sludge show a major constituent to be necrotic collagen from the donor bile duct walls.
D000469:Alkaline Phosphatase / Q000378:metabolism; D001646:Bile / Q000032:analysis* / Q000382:microbiology; D001647:Bile Acids and Salts / Q000032:analysis; D001652:Bile Ducts; D001660:Biliary Tract Diseases / Q000209:etiology*; D002784:Cholesterol / Q000032:analysis; D004926:Escherichia coli / Q000302:isolation & purification; D006801:Humans; D008102:Liver Circulation; D016031:Liver Transplantation; D014184:Transplantation, Homologous
D001647:Bile Acids and Salts; D002784:Cholesterol; D000469:Alkaline Phosphatase