Effect of an LH-RH antagonist on reproductive status of immature female rats.
Administration of the LH-RH antagonist, D-Phe2-D-Ala6-LH-RH (Wy-18, 185) to immature female rats from days 25--35 of age was without significant effect on day of vaginal opening (puberal onset), weights of the ovaries, uteri and anterior pituitary, and on ovarian histology on autopsy day 39.
D000818:Animals; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000494:pharmacology; D009929:Organ Size / Q000187:drug effects; D010053:Ovary / Q000187:drug effects; D010903:Pituitary Gland, Anterior / Q000187:drug effects; D051381:Rats; D012098:Reproduction / Q000187:drug effects*; D014599:Uterus / Q000187:drug effects; D014621:Vagina / Q000187:drug effects
D007987:Gonadotropin-Releasing Hormone