Comparative intraocular pressure effects of adsorbocarpine and isoptocarpine.
Nine symmetrical ocular hypertensives used Adsorbocarpine in one eye and Isoptocarpine in the other. Each medication was given twice daily for one week, then Isoptocarpine was used 4 time daily. The 2 drugs were equally effective as twice daily medications while Isoptocarpine 4 times daily was significantly more effective than either given twice daily. The pH of the Adsorbocarpine may not have been optimal although commercially available solutions were used. The results indicated that pilocarpine in either vehicle can lower intraocular pressure when given less than 4 times daily; however, conclusive studies are needed before this can be recommended as a widespread clinical practice.
D002986:Clinical Trials as Topic; D003692:Delayed-Action Preparations; D004334:Drug Administration Schedule; D005260:Female; D005901:Glaucoma / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008747:Methylcellulose / Q000008:administration & dosage*; D009883:Ophthalmic Solutions; D014677:Pharmaceutical Vehicles; D010862:Pilocarpine / Q000008:administration & dosage* / Q000627:therapeutic use; D011205:Povidone / Q000008:administration & dosage*
D003692:Delayed-Action Preparations; D009883:Ophthalmic Solutions; D014677:Pharmaceutical Vehicles; D010862:Pilocarpine; D008747:Methylcellulose; D011205:Povidone