Interstitial nephritis in rats produced by E. coli in adjuvant: immunological findings.
An increased incidence and severity of interstitial nephritis was produced in F344/fmai rats immunized with E. coli 022 in pertussis vaccine for 12-15 months. Migration of peritoneal exudate cells from immunized animals was inhibited by syngeneic kidney antigens. One out of twenty-eight immunized animals developed anti-TBM antibodies. In this model, interstitial nephritis develops in association with cell-mediated immunity to kidney tissue.
D000276:Adjuvants, Immunologic; D000818:Animals; D000941:Antigens; D000942:Antigens, Bacterial; D002464:Cell Migration Inhibition; D004926:Escherichia coli / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D007109:Immunity; D007111:Immunity, Cellular; D007668:Kidney / Q000276:immunology; D008099:Liver / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D009395:Nephritis, Interstitial / Q000276:immunology* / Q000473:pathology; D051381:Rats; D011916:Rats, Inbred F344
D000276:Adjuvants, Immunologic; D000941:Antigens; D000942:Antigens, Bacterial