title: [Mutagenic activity of antitubercular preparations: isonicotinic acid hydrazide and its derivatives].
abstract: Mutagenic activity of anti-tuberculosis drugs: isoniazide, phtivazide, metazide, larusan and saluzide soluble was studied using the semiquantitative plate technique of S. typhimurium tester strains TA 1950 and TA 1538 (after B. N. Ames) within the system of metabolic activation in vitro. No ability to induce gene mutations was found using this modification of the technique. A study of mutagenic activity of isoniazide and saluzide soluble in the experiments with a mammal as intermediate and using the tester strain TA 1950 showed a mutagenic effect of isoniazide and no such effect of saluzide soluble.
mesh_terms: D000818:Animals; D006835:Hydrazones / Q000633:toxicity*; D007538:Isoniazid / Q000031:analogs & derivatives* / Q000633:toxicity*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009153:Mutagens; D012486:Salmonella typhimurium / Q000235:genetics
chemical_list: D006835:Hydrazones; D009153:Mutagens; D007538:Isoniazid
vernacular_title: Izuchenie mutagennoĭ aktivnosti protivotuberkuleznykh preparatov: gidrazida izonikotinovoĭ kisloty i ego proizvodnykh.