title: Defective neutrophil migration in granuloma annulare, necrobiosis lipoidica, and sarcoidosis.
abstract: The neutrophil mobility in patients with granuloma annulare, necrobiosis lipoidica, and sarcoidosis was tested using both in vivo and in vitro techniques. Use of a skin window chamber for measurement of chemotaxis in vivo demonstrated defective neutrophil migration in each group. This contrasted with the finding that, in vitro, chemotaxis toward casein and endotoxin-activated sera was normal. The importance of this dissociation is discussed. Abnormal neutrophil accumulation at sites of inflammation may be of importance in the pathogenesis of these granulomatous disorders.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002464:Cell Migration Inhibition; D002634:Chemotaxis, Leukocyte; D005260:Female; D006099:Granuloma / Q000276:immunology*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D009335:Necrobiosis Lipoidica / Q000276:immunology*; D009504:Neutrophils / Q000276:immunology; D012507:Sarcoidosis / Q000276:immunology*; D012871:Skin Diseases / Q000276:immunology*; D012884:Skin Window Technique