Chemotactic activity of polymorphonuclear leukocytes to Streptococcus pyogenes.
Influence of two different streptococcal group A type 12 strains on chemotactic activity of polymorphonuclear leukocytes (PMN) was investigated in vitro and in vivo. The strains differed only in presence of M protein. In both conditions, the inhibition of the chemotaxis of the PMN after their treatment with M positive strains was observed. These results suggest that M protein of streptococci inhibits chemotaxis of PMN and therefore they can weaken defensive mechanisms of infected organism.
D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology; D001426:Bacterial Proteins / Q000494:pharmacology; D002452:Cell Count; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D008297:Male; D009504:Neutrophils / Q000276:immunology; D010587:Phagocytosis; D011817:Rabbits; D013290:Streptococcal Infections / Q000276:immunology; D013297:Streptococcus pyogenes / Q000276:immunology
D001426:Bacterial Proteins