The management of acute quinidine intoxication.
A 16-year-old patient survived severe intoxication with quinidine. Hypotension, rapidly progressing to oliguria and shock, was resistant to the usual therapeutic interventions but responded favorably to the use of an intra-aortic balloon pump. Some hemodynamic implications are discussed. Pulmonary edema occurred and was treated with positive end-expiratory pressure. Electrocardiographic disturbances in conduction, transient bradycardia and recurrent ventricular arrhythmias characterized the initial 36-hour critical period. Unexplained electrolyte abnormalities occurred and further complicated management.
D000293:Adolescent; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D001243:Assisted Circulation; D002648:Child; D005260:Female; D005676:Gravity Suits; D006464:Hemoperfusion; D006801:Humans; D007022:Hypotension / Q000139:chemically induced* / Q000628:therapy*; D007423:Intra-Aortic Balloon Pumping; D009846:Oliguria / Q000139:chemically induced; D010138:Pacemaker, Artificial; D011175:Positive-Pressure Respiration; D011654:Pulmonary Edema / Q000139:chemically induced; D011802:Quinidine / Q000506:poisoning*; D012769:Shock / Q000139:chemically induced; D014883:Water-Electrolyte Imbalance / Q000139:chemically induced
D011802:Quinidine