[Iron overload: effect on specific and nonspecific immunity].
Acute overload with an iron salt in mice enhanced the virulence of a relatively avirulent type of Salmonella typhimurium in a dose-dependent fashion. Iron administration also partly abolished specific immunity. Ferritin iron did not display the virulence-enhancing effect.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000918:Antibody Specificity / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005293:Ferritins / Q000008:administration & dosage; D007109:Immunity / Q000187:drug effects*; D007501:Iron / Q000008:administration & dosage*; D007781:Lactoferrin / Q000008:administration & dosage; D008297:Male; D051379:Mice; D012486:Salmonella typhimurium / Q000276:immunology; D014168:Transferrin / Q000008:administration & dosage; D014774:Virulence / Q000187:drug effects
D014168:Transferrin; D005293:Ferritins; D007501:Iron; D007781:Lactoferrin
Eisenüberladung: Einfluss auf spezifische und unspezifische Immunität.