Immunoglobulin deposition in the kidney in pre-eclampsia: its significance.
Renal biopsies from two patients with classical toxaemia of pregnancy demonstrated heavy deposition of IgG and IgA in a predominantly finely granular pattern. It is suggested that this may be a manifestation of immune complex formation and may provide further evidence for an immunological basis for the renal lesion of this poorly understood disease process.
D000328:Adult; D000936:Antigen-Antibody Complex; D000959:Antihypertensive Agents / Q000627:therapeutic use; D004232:Diuretics / Q000627:therapeutic use; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D007074:Immunoglobulin G / Q000032:analysis*; D007231:Infant, Newborn; D007668:Kidney / Q000276:immunology / Q000473:pathology; D008297:Male; D011225:Pre-Eclampsia / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D011247:Pregnancy; D014310:Triplets
D000936:Antigen-Antibody Complex; D000959:Antihypertensive Agents; D004232:Diuretics; D007070:Immunoglobulin A; D007074:Immunoglobulin G