title: Studies on the modes of action of azaserine in Escherichia coli. Mechanism of resistance to azaserine.
abstract: Growth of wildtype Escherichia coli was inhibited by azaserine. There was an inverse relationship between the initial rate of uptake of phenylalanine and the azaserine concentration. Moderately azaserine-resistant mutants exhibited an initial rate that was similar to that of an aroP mutant, but highly azaserine-resistant mutants exhibited little, if any, uptake of phenylalanine. All of the azaserine-resistant organisms tested harboured a mutation in the aroP+ gene. However, resistance to the antibiotic was not due solely to this lesion.
mesh_terms: D001224:Aspartic Acid / Q000378:metabolism; D001377:Azaserine / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D009154:Mutation; D010649:Phenylalanine / Q000378:metabolism; D013237:Stereoisomerism; D014161:Transduction, Genetic
chemical_list: D001224:Aspartic Acid; D010649:Phenylalanine; D001377:Azaserine; D005947:Glucose