Lymphoid thyroiditis following immunization with group A streptococcal vaccine.
Severe lymphoid thyroiditis and associated hypothyroidism occurred in all of 7 male and 4 female F(7) derivatives (seventh generation) of rats immunized in each generation against Group A streptococci. This evidence of thyroiditis produced by immunization against a nonthyroidal antigen suggests that some cases of Hashimoto's thyroiditis in humans may result from nonspecific immune responses.
D000818:Animals; D001428:Bacterial Vaccines / Q000009:adverse effects*; D051381:Rats; D013290:Streptococcal Infections / Q000517:prevention & control*; D013297:Streptococcus pyogenes; D013967:Thyroiditis, Autoimmune / Q000209:etiology*; D014611:Vaccination / Q000009:adverse effects
D001428:Bacterial Vaccines