Disulfiram implantation. A placebo-controlled trial with two-year follow-up.
Ten alcoholics implanted with disulfiram had longer periods of abstinence after treatment than did 10 alcoholics implanted with placebo; 7 of the disulfiram-implanted patients experienced a disulfiram-ethanol reaction in uncontrolled drinking situations, while none of the placebo-implanted patients did.
D000328:Adult; D000437:Alcoholism / Q000534:rehabilitation*; D002986:Clinical Trials as Topic; D004221:Disulfiram / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use; D004311:Double-Blind Method; D004343:Drug Implants / Q000009:adverse effects; D004347:Drug Interactions; D000431:Ethanol / Q000009:adverse effects; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010919:Placebos
D004343:Drug Implants; D010919:Placebos; D000431:Ethanol; D004221:Disulfiram