title: Chemoimmunotherapy of head and neck cancer.
abstract: The present review aims at developing a perspective for surgeons of the role of chemoimmunotherapy in the management of head and neck cancer. The biochemical pharmacology of high dose methotrexate with leucovorin "rescue" is also discussed. The need for a combined modality approach in the treatment of patients with this cancer is emphasized.
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D001500:BCG Vaccine; D004359:Drug Therapy, Combination; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000276:immunology / Q000628:therapy; D006801:Humans; D007261:Infusions, Intra-Arterial; D002955:Leucovorin / Q000494:pharmacology; D008727:Methotrexate / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D009163:Mycobacterium bovis
chemical_list: D000970:Antineoplastic Agents; D001500:BCG Vaccine; D002955:Leucovorin; D008727:Methotrexate