1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl]-1H-imidazole nitrate, a new potent antifungal agent.
The preparation and antifungal properties of 1-[4-(4-chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl]-1H-imidazole nitrate 1 are described. It is particularly effective against in vivo Candida albicans infections (mice), maintaining good activity down to 0.25% formulation strength and showing unusually low reinfection rates after treatment is ended.
D000818:Animals; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D002176:Candida albicans / Q000187:drug effects; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy; D002722:Chlorobenzenes / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D005260:Female; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D007928:Lethal Dose 50; D051379:Mice; D008826:Microbial Sensitivity Tests; D008864:Microsporum / Q000187:drug effects; D009153:Mutagens / Q000138:chemical synthesis; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D012486:Salmonella typhimurium / Q000187:drug effects; D014249:Trichophyton / Q000187:drug effects
D000935:Antifungal Agents; D002722:Chlorobenzenes; D007093:Imidazoles; D009153:Mutagens