Immunohistochemical studies of the human cutaneous basement membrane-anchoring fibril complex.
Antiserum to the human cutaneous basement membrane-anchoring fibril complex specifically binds to the basement membrane zone of normal human skin as demonstrated by indirect immunofluorescence and, in addition, cross-reacts with normal human glomerulus. This antiserum does not prevent binding of pemphigoid antibody to its specific antigen; thus the antigen of bullous pemphigoid is unlikely to be a component of the cutaneous basement membrane (basal lamina).
D000941:Antigens; D001485:Basement Membrane / Q000276:immunology*; D001666:Binding Sites, Antibody; D005455:Fluorescent Antibody Technique; D006801:Humans; D007106:Immune Sera; D007678:Kidney Glomerulus / Q000276:immunology; D012867:Skin / Q000276:immunology*; D012872:Skin Diseases, Vesiculobullous / Q000276:immunology*
D000941:Antigens; D007106:Immune Sera