title: A clinical pilot study on preformed autologous ossicles. I.
abstract: The study is part of a project aimed at obtaining an autologous, preformed transplant for reconstruction of a defect ossicular chain. In animal experiments we found that bone could be produced in a titanium mould placed in the tibia of the rabbit and dog. To find out whether this observation was applicable in man, 5 patients with ossicular defects were selected. A titanium mould containing two chambers was placed in the proximal tibial metaphysis for 6 months. When the moulds were extracted bone was found in 7 of the 10 chambers. In 2 of these the bone was stable and suitable for ossiculoplasty. On histological examination the same picture as in the animal experiments was found, an outer layer of cortical bone surrounding a system of spongy bone with marrow and haematopoietic cells. Microradiological examination verified the presence of mineralized bone tissue.
mesh_terms: D000328:Adult; D016025:Bone Transplantation; D001842:Bone and Bones / Q000502:physiology; D002986:Clinical Trials as Topic; D004429:Ear Ossicles / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008722:Methods; D008852:Microradiography; D008875:Middle Aged; D010012:Osteogenesis; D010865:Pilot Projects; D019736:Prostheses and Implants; D012038:Regeneration; D014025:Titanium; D014182:Transplantation, Autologous
chemical_list: D014025:Titanium