title: An immunohematologic complication of isoniazid.
abstract: The characteristics of an immunohematologic reaction to isoniazid are described with emphasis on the mechanism of development of the positive antiglobulin test. In contrast to previous findings, the antibody is a firmly bound IgG complement-binding antibody, reacting best at 37 degrees C by antiglobulin techniques and only with isoniazid presensitized cells. A method for preparing isoniazid-sensitized cells is described.
mesh_terms: D000328:Adult; D000917:Antibody Formation; D000918:Antibody Specificity; D000936:Antigen-Antibody Complex; D000941:Antigens; D002462:Cell Membrane / Q000276:immunology; D003165:Complement System Proteins; D003298:Coombs Test; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G; D007158:Immunologic Techniques; D007538:Isoniazid / Q000009:adverse effects* / Q000276:immunology / Q000627:therapeutic use; D014376:Tuberculosis / Q000188:drug therapy
chemical_list: D000936:Antigen-Antibody Complex; D000941:Antigens; D007074:Immunoglobulin G; D003165:Complement System Proteins; D007538:Isoniazid