[Effectiveness of two Ca-antagonistic drugs on angina pectoris: nifedipine and verapamil versus nitroderivative and beta-blocking drugs (author's transl)].
The Authors, using cycle ergometer tests, assess the effectiveness of two Ca-antagonistic drugs, nifedipine and verapamil, administered full strength to patients suffering from typical angina from effort. The true effectiveness of these drugs was tested by comparing the results with those obtained with placebo, isosorbide dinitrate and propranolol. The effect of nifedipine proved statistically significant (p less than 0.01) with respect to the parameters: double product, time of insurgence of angor and time of appearance of electrocardiographic anomalies. Verapamil proved slightly significant (p less than 0.05) only with regard to time of appearance of electrocardiographic anomalies. There follows a brief discussion of the differences between these results. Isosorbide dinitrate and propranolol increase tolerance to effort with respect to placebo treatment. These results are statistically significant on all parameters used.
D000787:Angina Pectoris / Q000188:drug therapy*; D002118:Calcium / Q000378:metabolism*; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D006801:Humans; D007548:Isosorbide Dinitrate / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism; D009543:Nifedipine / Q000627:therapeutic use*; D010919:Placebos; D011433:Propranolol / Q000627:therapeutic use*; D011725:Pyridines / Q000627:therapeutic use*; D014700:Verapamil / Q000627:therapeutic use*
D010919:Placebos; D011725:Pyridines; D011433:Propranolol; D014700:Verapamil; D009543:Nifedipine; D007548:Isosorbide Dinitrate; D002118:Calcium
Azione antianginosa di due farmaci calcio-antagonisti: nifedipina e verapamil in confronto a nitroderivato e a beta-bloccante.