Differential tolerance of thymus-independent and thymus-dependent antibody responses.
The effect of pre-immunization with soluble haptenated serum proteins or haptenated carbohydrates on the subsequent responses to the hapten in thymus-dependent or thymus-independent form was investigated. In certain cases both thymus-dependent and -independent responses were suppressed whilst in others a differential suppression of thymus-independent responsiveness was observed. These results are discussed in terms of B-cell subpopulations and mechanisms of tolerance induction.
D000818:Animals; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology*; D001798:Blood Proteins / Q000276:immunology; D002241:Carbohydrates / Q000276:immunology; D004136:Dinitrobenzenes / Q000276:immunology; D005260:Female; D006241:Haptens; D006462:Hemolytic Plaque Technique; D007165:Immunosuppression Therapy; D008211:Lymphocyte Cooperation; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008819:Mice, Nude; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000276:immunology*
D001798:Blood Proteins; D002241:Carbohydrates; D004136:Dinitrobenzenes; D006241:Haptens