[Preoperative immunosuppression in the kidney-transplanted dog in connection with specific antigenic pre-treatment].
Postoperative, nonspecific routine immunosuppressive therapy fails in up to 50% in human cadaver renal transplantation. Donorspecific preoperative immunological conditioning of the host is harder to induce in dogs than in some rodents. In a pilot study 2 i.v. donorblood injections on days -18 and -11 followed by a 6-day preoperative pulse without any postoperative therapy induce a significant albeit limited prolongation of graft function.
D000818:Animals; D000941:Antigens / Q000008:administration & dosage; D000961:Antilymphocyte Serum / Q000627:therapeutic use; D004285:Dogs; D006084:Graft Rejection; D007165:Immunosuppression Therapy; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation; D013601:T-Lymphocytes / Q000276:immunology; D013997:Time Factors; D014184:Transplantation, Homologous
D000941:Antigens; D000961:Antilymphocyte Serum; D007166:Immunosuppressive Agents
Ausschliesslich präoperative Immunsuppression beim nierentransplantierten Hund in Verbindung mit spezifischer Antigen-Vorbehandlung.