[Azabutyron concentration in the blood plasma and the hemodynamic effects of the preparation].
In patients presenting mitral and aortal valvular defects with contemplated valve prosthetics it was shown that after an intravenous administration of azabutyrone in a dose of 4 mg/kg the drug produced a hypotensive effect in the large circulation, reduced insignificantly the cardiac output, venous pressure and the total peripheral resistance, inducing, at the same time, a short-term rise of the heart rate. The drug forced down materially (by more than 50 per cent) the pulmonary artery pressure in patients with pulmonary hypertension. The azabutyrone effects were seen to continue for 30 minutes with its blood plasma concentration of 1.5--3.0 gamma/ml. A clearcut correlation between the plasma content and the effect of the drug could be noted only as concerns the hypotensive action of azabutyrone in the lesser circulation.
D002090:Butyrophenones / Q000097:blood*; D002986:Clinical Trials as Topic; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D004562:Electrocardiography; D004569:Electroencephalography; D006349:Heart Valve Diseases / Q000601:surgery; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D010879:Piperazines / Q000097:blood; D013997:Time Factors; D014149:Tranquilizing Agents / Q000097:blood*
D002090:Butyrophenones; D010879:Piperazines; D014149:Tranquilizing Agents; C011672:azabutyrone
Kontsentratsiia azabutirona v plazme krovi i gemodinamicheskie éffekty preparata.