Splenic transposition with ligation of the vascular pedicle in rodents. Immunological consequences.
By splenic subcutaneous transposition and ligation of the vascular pedicle, the direct relation spleen-liver was interrupted in rodents infected with malaria. It was demonstrated that in this situation detoxification of the liver and recovery from malaria was evidently hampered by the lack of a direct splenic cell supply, due to retardation of the homing and differentiation in the spleen of precursors of immunologically competent cells. In the presence of blood-borne antigens and/or hepatotoxins, this simple 'shunt' operation appears to constitute a serious immunological handicap. However, it may be a useful model for the study of cellular and microenvironmental interrelationships of the immune response versus blood-borne antigens.
D000818:Animals; D001402:B-Lymphocytes; D005849:Gerbillinae; D008099:Liver / Q000473:pathology; D008288:Malaria / Q000276:immunology*; D010962:Plasmodium berghei; D011168:Portal System / Q000601:surgery*; D051381:Rats; D013154:Spleen / Q000276:immunology / Q000473:pathology / Q000637:transplantation*; D013601:T-Lymphocytes