[Interrelationships in experiments in vitro between the migration activity of leukocytes and RNA and DNA synthesis].
The following correlations were revealed in the parallel study of leukocyte migration in vitro in the presence of a specific antigen and of spontaneous RNA and DNA synthesis in the cultured lymphocytes: 1) a direct correlation between the RNA and DNA synthesis in lymphocytes; 2) a close correlation between the antigen-induced migration and the levels of RNA and DNA synthesis. The effect of the antigen was evidenced by the inhibition or stimulation of leukocyte migration. A high ratio of RNA synthesis to DNA synthesis corresponded to the migration inhibition and a low one--to the migration stimulation. The ratio value varied mainly on account of the changes in the level of DNA synthesis. Participation of T and B cells in the regulation of the antigen-induced leukocyte mobility is discussed.
D000942:Antigens, Bacterial; D001402:B-Lymphocytes / Q000276:immunology*; D002465:Cell Movement; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis*; D006801:Humans; D066298:In Vitro Techniques; D008263:Macrophage Migration-Inhibitory Factors / Q000096:biosynthesis; D012313:RNA / Q000096:biosynthesis*; D012213:Rheumatic Fever / Q000276:immunology*; D013297:Streptococcus pyogenes / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D000942:Antigens, Bacterial; D008263:Macrophage Migration-Inhibitory Factors; D012313:RNA; D004247:DNA
O sootnosheniiakh v opytakh in vitro mezhdu migratisionnoĭ aktivnost'iu leĭkotsitov i sintezom RNK i DNK.