Serum from LPS nonresponder C3H/HeJ mice does not support the formation of functional EAC reagents.
Serum from C3H/HeJ mice in contrast to serum from other mouse strains does not convert EA into EAC. A factor in supportive serum permits nonsupportive C3H/HeJ serum to produce a functional EAC-rosetting reagent. This factor is heat stable. Its concentration in serum parallels the sensitivity of mice to LPS. It is absent or inoperative when sensitivity is reduced on a genetic basis and increased when sensitivity is increased by treatment with BCG.
D000818:Animals; D001500:BCG Vaccine; D003165:Complement System Proteins; D004306:Dose-Response Relationship, Immunologic; D008070:Lipopolysaccharides / Q000494:pharmacology*; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H / Q000276:immunology*; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009163:Mycobacterium bovis / Q000276:immunology; D009374:Neoplasms, Experimental / Q000276:immunology; D012397:Rosette Formation; D013045:Species Specificity
D001500:BCG Vaccine; D008070:Lipopolysaccharides; D003165:Complement System Proteins