title: Transferable antibiotic resistance in enterobacteriaceae isolated from urinary tract infections in general practice.
abstract: 138 different coliform isolates from patients with UTI in 2 General Practices in Stockport, England, showed an incidence of drug resistance of 36%: 47% of these strains transferred resistance to E. coli K12. Multiple resistance, i.e. resistance to more than 2 drugs occurred in more than a quarter of resistant isolates and sulphonamide resistance was most common. More than twice as many strains in this series (1973--74) were sulphonamide resistant compared with a previous survey (1968--70). MIC values of R+ resistant isolates were much higher with sulphonamide resistant strains than the probable urine levels during therapy, but the situation with ampicillin and tetracycline levels was variable.
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D004754:Enterobacter / Q000187:drug effects; D004755:Enterobacteriaceae / Q000235:genetics* / Q000302:isolation & purification; D004926:Escherichia coli / Q000187:drug effects; D005827:Genetics, Microbial; D006801:Humans; D007709:Klebsiella / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011511:Proteus / Q000187:drug effects; D014552:Urinary Tract Infections / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents