Oral use of chlorhexidine gluconate toothpaste in epileptic children.
The purpose of this clinical study was to evaluate the effect of a 3-min daily toothbrushing with 1% chlorhexidine gluconate toothpaste on dental plaque, gingivitis and gingival hyperplasia in 30 mentally retarded epileptic children treated with phenytoin. A double-blind cross-over technique was used. Brushing once daily for 2 months with 1% chlorhexidine gluconate toothpaste resulted in significantly lower Pl I and G I values. Gingival hyperplasia was not significantly reduced by the use of the chlorhexidine toothpaste.
D000284:Administration, Oral; D000293:Adolescent; D001645:Biguanides / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D002710:Chlorhexidine / Q000008:administration & dosage / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003773:Dental Plaque / Q000517:prevention & control*; D003802:Dentifrices; D004311:Double-Blind Method; D004341:Drug Evaluation; D004827:Epilepsy / Q000188:drug therapy; D005260:Female; D005885:Gingival Hyperplasia / Q000517:prevention & control*; D005891:Gingivitis / Q000517:prevention & control*; D006801:Humans; D008607:Intellectual Disability / Q000188:drug therapy; D008297:Male; D010672:Phenytoin / Q000009:adverse effects / Q000627:therapeutic use; D010919:Placebos; D014100:Toothpastes
D001645:Biguanides; D003802:Dentifrices; D010919:Placebos; D014100:Toothpastes; D010672:Phenytoin; D002710:Chlorhexidine