The effect of prednisolone and metyrapone on FSH release induced by the administration of LRH.
The response of follicle-stimulating hormone (FSH) to a single injection of synthetic LRH was established in 7 and 6 women following an intramuscular dose of 0.2 mg and 0.1 mg. The secretion of FSH was greater in the group injected with 0.2 mg LRH than in the group injected with 0.1 mg. On the other hand, the response of FSH to a single injection of LRH (0.1 mg/subject) was established in 7 men before and after the pretreatment with metyrapone for one dat (4.5 g/subject). Pretreatment with metyrapone provoked a hypersecretion of FSH following a single injection of synthetic LRH. Seven women, 21--48 years of age who were treated with prednisolone for at least 1.5 months were examined for the responsiveness of the anterior pituitary to a single injection of synthetic LRH (0.2 MG). The secretion of FSH was not suppressed and the maximal serum level of FSH was observed 60 min after LRH injection.
D015065:17-Hydroxycorticosteroids / Q000652:urine; D000284:Administration, Oral; D000328:Adult; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008797:Metyrapone / Q000494:pharmacology*; D008875:Middle Aged; D011239:Prednisolone / Q000494:pharmacology*
D015065:17-Hydroxycorticosteroids; D007987:Gonadotropin-Releasing Hormone; D005640:Follicle Stimulating Hormone; D011239:Prednisolone; D008797:Metyrapone