title: Mianserin in the treatment of depressive illness and anxiety states in general practice.
abstract: 1. In an initial study in general practice, mianserin was shown to be of similar antidepressant efficacy to imipramine. 2. A subsequent placebo-controlled study confirmed that mianserin is an effective as imipramine, and also demonstrated that both mianserin and imipramine are superior to placebo in the treatment of depression in general practice. 3. In a third trial, mianserin was found to be as effective as diazepam in the treatment of anxiety states in general practice. 4. The overall incidence of side-effects in this series of studies, either with mianserin or with the comparison drugs, was very low.
mesh_terms: D000293:Adolescent; D000328:Adult; D001007:Anxiety / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D003863:Depression / Q000188:drug therapy*; D003975:Diazepam / Q000009:adverse effects / Q000627:therapeutic use; D003984:Dibenzazepines / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008803:Mianserin / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D010919:Placebos
chemical_list: D003984:Dibenzazepines; D010919:Placebos; D008803:Mianserin; D003975:Diazepam