title: Membranous glomerulonephritis associated with anti-tubular and anti-alveolar basement membrane antibodies.
abstract: The renal biopsy of a 3-year old boy with complete Fanconi syndrome showed the association of a membranous glomerulonephritis with severe tubulointerstial changes. Immunofluorescence microscopy disclosed linear and granular deposits of Ig along tubular basement membranes. The presence of anti-tubular basement membrane antibodies in the patient's serum was demonstrated by indirect immunofluorescence and radioimmunoassay. The child also developed pulmonary involvement associated with episodes of acute anemia. Anti-alveolar basement membrane antibodies were detected by indirect immunofluorescence. The present case is the first reported example of auto-immune disease characterized by the presence of anti-tubular and alveolar basement membrane antibodies associated with an immune complex glomerulonephritis.
mesh_terms: D001323:Autoantibodies / Q000302:isolation & purification*; D001485:Basement Membrane / Q000276:immunology*; D001706:Biopsy; D002675:Child, Preschool; D003176:Complement C3 / Q000302:isolation & purification; D005198:Fanconi Syndrome / Q000150:complications; D005455:Fluorescent Antibody Technique; D005921:Glomerulonephritis / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007074:Immunoglobulin G / Q000302:isolation & purification; D007075:Immunoglobulin M / Q000302:isolation & purification; D007678:Kidney Glomerulus / Q000473:pathology; D007684:Kidney Tubules / Q000276:immunology* / Q000473:pathology; D008297:Male; D011650:Pulmonary Alveoli / Q000276:immunology*; D011863:Radioimmunoassay
chemical_list: D001323:Autoantibodies; D003176:Complement C3; D007074:Immunoglobulin G; D007075:Immunoglobulin M