Soft tissue responses to high frequency use of experimental and commercial mouthwashes.
A recent study reported that regular use of commercial mouthwashes produced a significant incidence of oral reactions, including epithelial peeling, inflammation, ulceration and geographic tongue-like lesions. In view of the widespread use of these preparations, without apparent deleterious effects, an investigation of two commercial preparations (Scope, Listerine) and an experimental mouthwash containing cetyl pyridinium chloride was undertaken to assess the possible irritant effects on the oral soft tissue under stringent test conditions. A double blind design was used and soft tissue effects were measured over a two week period. Rinses were used full strength, 20 cc 3 times daily. Examinations were conducted by an oral pathologist at the start and conclusion of the test period, and a record was made of the occurrence of erythema, hyperemia/prominent vasculature, inflammation, petechia, keratosis, tongue coating, and ulceration. These observations did not reveal any soft tissue conditions beyond those which would be expected in the normal population.
D000293:Adolescent; D000328:Adult; D002594:Cetylpyridinium / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004890:Erythema / Q000139:chemically induced*; D005260:Female; D006801:Humans; D006940:Hyperemia / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000139:chemically induced; D009061:Mouth Mucosa / Q000187:drug effects*; D009067:Mouthwashes / Q000008:administration & dosage / Q000494:pharmacology*; D011726:Pyridinium Compounds / Q000494:pharmacology*; D013997:Time Factors; D014059:Tongue / Q000187:drug effects
D009067:Mouthwashes; D011726:Pyridinium Compounds; D002594:Cetylpyridinium