Effect of prolonged fasting upon insulin and glucagon secretion from isolated rat pancreatic islets.
To study insulin-glucagon interrelationships in the regulation of pancreatic islet functions, glucose-mediated insulin and glucagon secretion have been studied in isolated pancreatic islets from fed and from 4 and 8-day fasted rats. At low glucose levels (50 mg %) a continuous decrease of insulin and increase of glucagon secretion were observed during prolonged fasting. High glucose concentrations 300 mg %) stimulated insulin and inhibited glucagon secretion until 4 days, but did not cause any effect after 8 days fasting. These results suggest that the secretory mechanisms of the two hormones may have a common basis.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D005215:Fasting; D005934:Glucagon / Q000032:analysis / Q000378:metabolism*; D007328:Insulin / Q000032:analysis / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000378:metabolism*; D008297:Male; D051381:Rats; D013997:Time Factors
D001786:Blood Glucose; D007328:Insulin; D005934:Glucagon