Oxantel-pyrantel in various regimens for the treatment of soil transmitted helminthiasis in rural and urban communities.
204 individuals from a rural community were given a single dose of oxantel-pyrantel at 15mg/kg bodyweight and if still infected, 20mg/kg bodyweight, with cure rates of 100%, 53% and 71% for ascariasis, trichuriasis and hookworm infection, respectively. From an urban community, 124 patients were given the same drug either as 15mg/kg bodyweight given twice in one day, with an interval of about 12 hours, or 20mg/kg bodyweight given daily for 2 days. Cure rates obtained were 100% in both groups for ascariasis; 89.2% of those given the first regimen were cured of trichuriasis compared with 71.2% of those on the second. For trichuriasis, oxantel-pyrantel given twice, 12 hours apart, appears to be the best treatment schedule and further clinical trials using this regimen are suggested.
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D004334:Drug Administration Schedule; D004338:Drug Combinations; D005243:Feces / Q000469:parasitology; D005260:Female; D006373:Helminthiasis / Q000188:drug therapy* / Q000453:epidemiology / Q000469:parasitology; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D010679:Philippines; D011715:Pyrantel / Q000008:administration & dosage / Q000627:therapeutic use*; D011743:Pyrimidines / Q000627:therapeutic use*; D012424:Rural Population; D012987:Soil; D013343:Styrenes / Q000627:therapeutic use; D014505:Urban Population
D004338:Drug Combinations; D011743:Pyrimidines; D012987:Soil; D013343:Styrenes; D011715:Pyrantel