Factors determining occurrence of cleft lip and cleft palate.
The modern care of newborn infants with oral clefts renders their survival possible. Since they will eventually reproduce, a slight increase in the incidence may be expected and genetic counseling will be requested on occasion. The cleft lip with or without cleft palate has a different genetic inclination from isolated cleft palate and the risk of recurrence is different. Drugs, such as antiepileptics, salicylates, benzodiazepines and cortisone, have a role in causing oral clefts. When an oral cleft is a part of a syndrome, the genetics of the particular syndrome must be outlined and genetic counseling is given accordingly. Oral clefts alone are usually multifactorial.
D000818:Animals; D002971:Cleft Lip / Q000145:classification / Q000196:embryology / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D002972:Cleft Palate / Q000145:classification / Q000196:embryology / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D003241:Consanguinity; D003710:Demography; D005060:Europe; D005145:Face; D005260:Female; D005817:Genetic Counseling; D006801:Humans; D007231:Infant, Newborn; D007564:Japan; D008297:Male; D011247:Pregnancy; D012008:Recurrence; D012306:Risk; D012923:Social Class; D013577:Syndrome