title: Biochemical differences between serotypes of Cryptococcus neoformans.
abstract: Prior studies have shown that C. neoformans isolates belonging to serotypes B and C differed from serotype A and D isolates in respect to the morphology of the perfect state, geographic distribution within the U.S.A. and frequency of isolation from avian droppings. The current study found that uptake of radiolabeled l-malic acid was approximately tenfold greater in serotype B and C than in A and D isolates. Assimilation of l-malic, fumaric and succinic acids also distinguished serotypes B and C from A and D. Greening of Guizotia seed agar occurred with 18 of 32 serotype B and C but in none of 91 serotype A or D isolates. The one property not following the same line of division was relatively slow creatinine assimilation, which distinguished type A alone.
mesh_terms: D003404:Creatinine / Q000378:metabolism; D003454:Cryptococcus / Q000145:classification*; D003455:Cryptococcus neoformans / Q000145:classification* / Q000254:growth & development / Q000378:metabolism; D003470:Culture Media; D003998:Dicarboxylic Acids / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D008291:Malate Dehydrogenase / Q000378:metabolism; D008293:Malates / Q000378:metabolism; D012639:Seeds; D012703:Serotyping
chemical_list: D003470:Culture Media; D003998:Dicarboxylic Acids; D008293:Malates; D003404:Creatinine; D008291:Malate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase