Levamisole and cellular immunity in rheumatoid arthritis--a review.
It has been suggested that many of the pathological changes in rheumatoid arthritis can be explained on the basis of T cell hypofunction and that the chronicity of the lesions can be maintained by abnormalities in macrophage and neutrophil function. Although there is some evidence to suggest that levamisole can correct many of these abnormalities and that its mechanism of action in this disease can therefore be explained the current, often conflicting, information does not offer proof of this suggestion and indeed some of the noted changes may merely represent secondary rather than primary events.
D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000276:immunology*; D002634:Chemotaxis, Leukocyte; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects*; D007978:Levamisole / Q000627:therapeutic use*; D008213:Lymphocyte Activation; D009504:Neutrophils / Q000276:immunology; D010587:Phagocytosis; D010835:Phytohemagglutinins; D012397:Rosette Formation; D012882:Skin Tests; D013601:T-Lymphocytes / Q000276:immunology
D010835:Phytohemagglutinins; D007978:Levamisole