Antigen-induced murine B cell lymphomas. I. Induction and characterization of CH1 and CH2.
Two unusual murine lymphomas, designated CH1 and CH2, were produced in the newly developed double congenic strain of mice, B10 H-2a H-4b p/Wts. Both tumors lack the T cell-specific antigen (thy-1), but express cell surface immunoglobulin and the H-2K, H-2D, and Ia specificities determined by the H-2a haplotype. Further studies have demonstrated that these tumors represent "early" B cells in that they express surface IgM (mu heavy and lambda light chains), but do not bear surface delta, gamma, or alpha heavy chains. CH1 and CH2 lack surface C3 receptors and results from assays for Fc receptors have proven variable. A competition radioimmunoassay directed against the gp71 group-specific antigen of Friend leukemia virus has shown that there is a murine leukemia virus associated with these tumors, however, we have been unable to establish a causal relationship between the virus and this malignancy. A comparison of the surface characteristics of these tumors with other mammalian B cell lymphomas is presented.
D000818:Animals; D000941:Antigens; D000954:Antigens, Surface; D001402:B-Lymphocytes / Q000276:immunology*; D002474:Cell-Free System; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005455:Fluorescent Antibody Technique; D006649:Histocompatibility Antigens; D008223:Lymphoma / Q000276:immunology* / Q000382:microbiology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009194:Myeloma Proteins; D009368:Neoplasm Transplantation; D011947:Receptors, Antigen, B-Cell
D000941:Antigens; D000954:Antigens, Surface; D006649:Histocompatibility Antigens; D009194:Myeloma Proteins; D011947:Receptors, Antigen, B-Cell