Streptococcal protein T induced hyperdelayed sensitivity and lymphocyte stimulation.
T protein was isolated from Streptococcus pyogenes types 1 and 12 by application CNBr-sepharose-trypsin and purified by ion exchange chromatography. It was indicated that purified T1 and T12 proteins have lymphocyte transforming activity. It was also observed that T12 protein induces immediate and delayed type hypersensitivity in guinea pigs previously sensitized with T12 antigen emulsified with complete FREUND's adjuvant.
D000818:Animals; D001426:Bacterial Proteins / Q000494:pharmacology*; D002478:Cells, Cultured; D005620:Freund's Adjuvant / Q000494:pharmacology; D006168:Guinea Pigs; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000139:chemically induced*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000187:drug effects*; D013297:Streptococcus pyogenes
D001426:Bacterial Proteins; D005620:Freund's Adjuvant