A controlled trial of L-tryptophan in mania.
A double-blind placebo-controlled trial of L-tryptophan, with pyridoxine and ascorbic acid, was carried out in 10 female patients suffering from mania. In contrast to earlier studies led by Prange and Murphy, L-tryptophan was found to be no better than placebo.
D000328:Adult; D001205:Ascorbic Acid / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004338:Drug Combinations; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D010919:Placebos; D011569:Psychiatric Status Rating Scales; D011736:Pyridoxine / Q000627:therapeutic use; D014364:Tryptophan / Q000627:therapeutic use*
D004338:Drug Combinations; D010919:Placebos; D014364:Tryptophan; D011736:Pyridoxine; D001205:Ascorbic Acid