[Stimulation of nonspecific resistance in mice with high- and low-molecular fractions of endotoxin on 2 models of Shigella infection].
The capacity of S. paratyphi B endotoxin and its high molecular (HMF) and low molecular (LMF) fractions to stimulate the resistance of mice to shigella infection in intraperitoneal and intranasal challenge was investigated. The HMF developed high activity after the intraperitoneal injection (efficiency index--EI = 2.8). All the preparations were less active on the lung model (EI = 1.6--1.7). Materials of this work lead to the conclusion that in studying the phenomenon of nonspecific resistance induction conditions providing antitoxic and antiinfectious resistance should be considered separately.
D000818:Animals; D004405:Dysentery, Bacillary / Q000276:immunology*; D004731:Endotoxins / Q000032:analysis / Q000276:immunology*; D007113:Immunity, Innate / Q000187:drug effects*; D051379:Mice; D008970:Molecular Weight; D012475:Salmonella; D012484:Salmonella paratyphi B; D012764:Shigella sonnei; D013268:Stimulation, Chemical
D004731:Endotoxins
Stimuliatsiia nespetsificheskoĭ rezistentnosti mysheĭ vysokomole-kuliarnoĭ i nizkomolekuliarnoĭ fraktsiiami éndotoksina na dvukh modeliakh shigelleznoĭ infektsii.