[Effect of alpha-mercaptopropionylglycine (alpha-MPG) and sodium dipropylacetate (DPA) on antibody formation (I) (author's transl)].
The humoral immuno-response: A study was carried out to determine the effect of alpha-MPG and DPA on humoral antibody formation. The following results were obtained: The 1st and 2nd immuno-responses in rabbits to bacterial alpha-amylase were potentiated by treatment with both alpha-MPG and DPA given i.p. for 10 days after the 1st immunization, but the treatment after the 2nd immunization did not affect the 2nd immuno-response. Formation of hemolytic plaque forming cells (HPFC) in the spleen of mice immunized with 5 X 10(8) sheep red blood cells (SRBC) was potentiated by the administration of the both drugs given i.p. for 5 days before or after the immunization. No appreciable formation of HPFC was observed by immunization with 5 X 10(6) SRBC, and here alpha-MPG or DPA were without effects. Immunization with more than 5 X 10(7) SRBC resulted in an increase of HPFC in a dose-dependent fashion. Such an increase was further reinforced by treatment with both drugs. HPFC increased with a single dose of alpha-MPG at 48 hr before or 24 approximately 72 hr after the immunization and also increased with that of DPA at 24 hr before or immediately after the SRBC treatment.
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000603:Amino Acids, Sulfur / Q000494:pharmacology*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D001773:Blood Cells / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006462:Hemolytic Plaque Technique; D007109:Immunity / Q000187:drug effects; D008297:Male; D051379:Mice; D011817:Rabbits; D013154:Spleen / Q000276:immunology; D008625:Tiopronin / Q000008:administration & dosage / Q000494:pharmacology*; D014635:Valproic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D000516:alpha-Amylases / Q000276:immunology
D000276:Adjuvants, Immunologic; D000603:Amino Acids, Sulfur; D014635:Valproic Acid; D008625:Tiopronin; D000516:alpha-Amylases