Mutagenicity of several classes of antitumor agents to Salmonella typhimurium TA98, TA100, and TA92.
The mutagenic activities of antitumor agents, including 5 antibiotics, 19 antimetabolites, 5 alkylating agents, 2 alkaloids, 1 enzyme, and 1 adrenal steroid hormone, were tested on Salmonella tyhimurium TA100, TA98, and TA92. Four of these, busulfan, carbazilquinone, 1-(4-amino-2-methylpyrimidine-5-yl)methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride, and pipobroman were shown for the first time to be mutagenic. Further, the known mutagenicities of five others, daunomycin hydrochloride, Adriamycin hydrochloride, mitomycin C, 6-mercaptopurine, and cyclophosphamide, were confirmed.
D000477:Alkylating Agents / Q000494:pharmacology; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D000964:Antimetabolites, Antineoplastic / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001215:Asparaginase / Q000494:pharmacology; D002273:Carcinogens; D004353:Drug Evaluation, Preclinical; D009153:Mutagens; D009154:Mutation / Q000187:drug effects; D011239:Prednisolone / Q000494:pharmacology; D012486:Salmonella typhimurium / Q000187:drug effects*; D014748:Vinca Alkaloids / Q000494:pharmacology
D000477:Alkylating Agents; D000903:Antibiotics, Antineoplastic; D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D002273:Carcinogens; D009153:Mutagens; D014748:Vinca Alkaloids; D011239:Prednisolone; D001215:Asparaginase