title: [Open study of befuraline (DIV 154) in 64 depressive patients (author's transl)].
abstract: The therapeutic efficacy of the new compound N-benzo[B]-furan-2-ylcarbonyl-N'-benzylpiperazine hydrochloride (befuraline) was evaluated in 64 patients presenting various depressive syndromes. Improvement was found in 33 cases (= 52%) under a daily dose of 150 mg befuraline; 31 of these patients improved within the first 8 days of treatment. Patients with endogenous depression responded favourably to the befuraline therapy, 23 (= 70%) of these (33) patients showing full recovery. Improvement was more frequently observed in patients with mild depression than in severe cases. It seems noteworthy that under befuraline treatment there was also a marked improvement in 21 cases in whom previous long-term therapy with other psychotropic drugs had remained ineffective. Side effects consisted mainly of reversible psycho-organic troubles; extrapyramidal disorders were not observed.
mesh_terms: D000328:Adult; D000368:Aged; D000928:Antidepressive Agents; D001572:Benzofurans / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003863:Depression / Q000150:complications / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000627:therapeutic use*; D010919:Placebos
chemical_list: D000928:Antidepressive Agents; D001572:Benzofurans; D010879:Piperazines; D010919:Placebos; C015697:befuraline
vernacular_title: Offener Versuch mit Befuraline (DIV 154) bei 64 depressiv Kranken.