title: Differences between cephalothin and newer parenterally absorbed cephalosporins in vitro: a justification for separate disks.
abstract: The activities of cefamandole and cefoxitin in vitro were compared with that of cephalothin against staphylococci and gram-negative bacilli. Cephalothin was the most active agent against staphylococci. Cefamandole exhibited the greatest activity against the Enterobacteriaceae, with the exceptions of Serratia marcescens and indole-positive Proteeae, against which cefoxitin was the most active antibiotic. The activity of newer cephalosporins that are resistant to the beta-lactamases of gram-negative bacteria renders untenable the status of cephalothin as the class representative of the cephalosporins for susceptibility testing.
mesh_terms: D000150:Acinetobacter / Q000187:drug effects; D000333:Aeromonas / Q000187:drug effects; D001419:Bacteria / Q000187:drug effects*; D001441:Bacteroides fragilis / Q000187:drug effects; D002511:Cephalosporins / Q000494:pharmacology*; D002512:Cephalothin / Q000494:pharmacology; D002954:Citrobacter / Q000187:drug effects; D004754:Enterobacter / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D007711:Klebsiella pneumoniae / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011511:Proteus / Q000187:drug effects; D011549:Pseudomonas / Q000187:drug effects; D012706:Serratia marcescens / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D002511:Cephalosporins; D002512:Cephalothin