Acute cardiac toxicity of antineoplastic agents as the first manifestation of pheochromocytoma.
A 47-year-old male with histiocytic lymphoma and no previous history of heart disease developed significant fluctuations of blood pressure, electrocardiographic evidence of myocardial ischemia, and life-threatening arrhythmia after the first dose of BACOP (bleomycin, adriamycin, cyclophosphamide, Oncovin, and prednisone) chemotherapy. The presence of pheochromocytoma was suspected, and it was demonstrated by elevated urinary metanephrines, catecholamines, and vanillylmandelic acid, and finally confirmed on autopsy. The possible role of chemotherapeutic agents in stimulating excessive catecholamine release, thus causing transient cardiac injury, is suggested.
D000310:Adrenal Gland Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001145:Arrhythmias, Cardiac / Q000209:etiology*; D002395:Catecholamines / Q000378:metabolism; D003327:Coronary Disease / Q000209:etiology*; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis* / Q000378:metabolism; D010673:Pheochromocytoma / Q000175:diagnosis* / Q000378:metabolism
D000970:Antineoplastic Agents; D002395:Catecholamines