[Assessment of the effect of obsidan on the contractile function of the heart in toxic goiter].
A method of acceleration kinetocardiography was applied to the study of the effect of obsidan on the contractile funciton of the heart in 153 patients suffering from toxic goiter with the visceropathic stage of the disease. Results of single and prolonged (up to 30-day) use of obsidan, and also effects in case of its combined with mercazolil corglycon or prednisolone prescription were assessed. The results obtained indicated that chronotropic action alone was expressed in case of oral single administration of obsidan, whereas its intravenous injection could cause suppression of the contractile function of the myocardium. Prolonged oral use of obsidan or of its combination with mercazolil was accompanied by a negative inotropic action on the myocardium. This could be prevented by a simultaneous prescription of corglycon or prednisolone. In prolonged use of obsidan one should take into consideration the initial condition of the intracardiac hemodynamics, since the latter is normalized in the presence of the hyperdynamia syndrome, but in case of the initial hypodynamic the treatment aggravates the hypodynamia syndrome.
D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D006111:Graves Disease / Q000188:drug therapy / Q000503:physiopathology*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007702:Kinetocardiography; D008297:Male; D008713:Methimazole / Q000627:therapeutic use; D009200:Myocardial Contraction / Q000187:drug effects*; D011239:Prednisolone / Q000627:therapeutic use; D011433:Propranolol / Q000627:therapeutic use*; D012210:Rhamnose / Q000031:analogs & derivatives / Q000627:therapeutic use; D013328:Strophanthins / Q000627:therapeutic use; D013997:Time Factors
D013328:Strophanthins; D008713:Methimazole; D011239:Prednisolone; D011433:Propranolol; D012210:Rhamnose
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