A female case of Kallmann's syndrome.
A case of 20-year-old woman with hypogonadotropic hypogonadism and anosmia is reported, since very few female cases of Kallmann's syndrome have been reported so far in Japan. Three uncles on the father's side had no children. Height was 168 cm, and arm span 165 cm. The olfactory test revealed complete anosmia. Bone age was 13 year. Chromosome was 46 XX and normal karyotype. Basal levels of serum FSH, LH and estrogens (E1, E2 and E3) were low. Serum FSH and LH levels rose slightly only after LH-RH administration, and did not increase in clomiphene test. Plasma estrogens did not increase after daily injection of 150 IU of HMG for 3 successive days. The response of serum GH to arginine infusion was normal, while that to insulin-induced hypoglycemia was poor.
D000328:Adult; D000886:Anthropometry; D001120:Arginine; D002996:Clomiphene; D004967:Estrogens / Q000097:blood / Q000652:urine; D005058:Eunuchism / Q000175:diagnosis*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D007006:Hypogonadism / Q000175:diagnosis*; D007328:Insulin; D007986:Luteinizing Hormone / Q000097:blood; D000857:Olfaction Disorders / Q000175:diagnosis*; D010808:Physical Examination; D011863:Radioimmunoassay / Q000379:methods; D013577:Syndrome; D013972:Thyrotropin / Q000097:blood
D004967:Estrogens; D007328:Insulin; D002996:Clomiphene; D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin; D013006:Growth Hormone; D001120:Arginine