Immune surveillance and tumors of the nervous system.
The theory of immune surveillance postulates that one function of the immune system is to eliminate small numbers of malignant cells that arise spontaneously within the organism. Although there has been a great deal of both clinical and experimental evidence in favor of thistheory as it applies to general oncology, the question of whether or not such a surveillance system would be effective for tumors arising within the nervous system has never been studied. The young of pregnant rats which had been exposed to the neurocarcinogen ethylnitrosourea (ENU) were divided into control, immunosuppressed, and immunoenhanced groups. These lifetime alterations of the immune system had no effect on the course of nervous system tumor fromation. We believe that the most likely explanation for our results is that the "immunological privilege" of the brain prevents the usual interaction of the neoplasm and the immune system from occurring.
D000818:Animals; D000961:Antilymphocyte Serum; D001500:BCG Vaccine; D002490:Central Nervous System / Q000276:immunology; D005038:Ethylnitrosourea; D005260:Female; D006968:Hypersensitivity, Delayed; D007109:Immunity; D007165:Immunosuppression Therapy; D009369:Neoplasms / Q000139:chemically induced / Q000276:immunology*; D009422:Nervous System Diseases / Q000139:chemically induced / Q000276:immunology*; D011247:Pregnancy; D051381:Rats; D016038:Skin Transplantation; D013934:Thymectomy; D014184:Transplantation, Homologous
D000961:Antilymphocyte Serum; D001500:BCG Vaccine; D005038:Ethylnitrosourea