Mutagenic effect of dichloromethane on Salmonella typhimurium.
The possible mutagenicity of the organic solvent dichloromethane was investigated with the mutation test as described by Ames et al. The compound was mutagenic in both tester strains used, namely TA98 and TA100. The administration of rat-liver homogenate did not appear to be essential though it slightly increased the number of mutations.
D005821:Genetic Techniques; D006843:Hydrocarbons, Chlorinated / Q000494:pharmacology*; D008752:Methylene Chloride / Q000494:pharmacology*; D008862:Microsomes, Liver / Q000378:metabolism; D009153:Mutagens; D012486:Salmonella typhimurium / Q000235:genetics*
D006843:Hydrocarbons, Chlorinated; D009153:Mutagens; D008752:Methylene Chloride