Poor hypotensive response and tachyphylaxis following intravenous labetalol.
Three renal patients with transplant kidneys and uncontrolled hypertension were treated with intravenous doses of labetalol. Only minor depressor effects were noted and tachyphylaxis developed in 1 patient. Other parenteral hypotensive agents reduced blood pressure satisfactorily.
D000328:Adult; D004983:Ethanolamines / Q000627:therapeutic use*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007263:Infusions, Parenteral; D007275:Injections, Intravenous; D016030:Kidney Transplantation; D007741:Labetalol / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D013618:Tachyphylaxis; D013997:Time Factors; D014184:Transplantation, Homologous
D004983:Ethanolamines; D007741:Labetalol