The degradation of DNA by hydrazine: identification of 3-ureidopyrazole as a product of the hydrazinolysis of deoxycytidylic acid residues.
The reaction of hydrazine with the cytosine residues of DNA yields 3-ureidopyrazole, in approximately 50% yield, in addition to the expected 3-aminopyrazole. This product has been identified by ultraviolet, infrared, nuclear magnetic resonance and mass spectroscopy. A product of the reaction of hydrazine hydrate with cytosine, formulated by others as NN'-di-(3-pyrazolyl) hydrazine, has been identified as 3-ureidopyrazole.
D000818:Animals; D002417:Cattle; D055598:Chemical Phenomena; D002621:Chemistry; D004247:DNA; D004269:DNA, Bacterial; D003845:Deoxycytosine Nucleotides; D004926:Escherichia coli; D006834:Hydrazines; D013058:Mass Spectrometry; D013055:Spectrophotometry, Infrared; D013950:Thymus Gland
D004269:DNA, Bacterial; D003845:Deoxycytosine Nucleotides; D006834:Hydrazines; D004247:DNA