[Validation of paternity in a father-mother-child trio, by the use of genetic markers. Description of a program to aid in the decision. Determination of the optimal sequence of examinations].
The knowledge of human polymorphism provides aid to the decision for the diagnosis parenthood. This work gives an algorithm of paternity diagnosis on a (presumed father, mother, child) triplet: the program verifies the logical relationships and calculates several indices used to estimate the likelihood of non-exclusion. We propose to attach greater importance to a neglected index: the percentage of subjects for which the paternity is excluded for the doublet (Mother, Child). Finally, we determine the most efficient and most economical sequence for the sequential use of genetic markers.
D000483:Alleles; D002648:Child; D003936:Diagnosis, Computer-Assisted; D005260:Female; D005821:Genetic Techniques; D005838:Genotype; D006801:Humans; D008297:Male; D010334:Paternity; D010641:Phenotype
Validation de paternité au sein d'un trio père-mère-enfant à partir des marqueurs génétiques. Description d'un programme d'aide à la décision. Détermination de la séquence optimale d'examens.