Guidelines for the management of transient ischemic attacks.
On the basis of a review of the literature on anticoagulant, antiplatelet, and surgical treatment, supplemented by our personal experience, we have developed guidelines for the management of patients with transient ischemic attacks (TIA). 1. The majority of patients with vertebral-basilar TIA are treated medically. 2. If a skilled surgeon and an experienced angiographer are available, patients with typical carotid TIA who are suitable medical risks should have angiography followed by carotid endarterectomy if an appropriate lesion is found. 3. Nonoperated patients with TIA of less than 2 months' duration are treated with 3 months of warfarin therapy (unless contraindicated) before treatment with aspirin is begun. 4. Nonoperated patients with continuing TIA of 2 or more months' duration are treated with aspirin unless there has been a recent increase in the frequency, duration, or severity of TIA. Under these circumstances, warfarin therapy is advised for 3 months before aspirin is started. Aspirin therapy should be continued until the patient has been free of TIA for 1 year. 5. No treatment is advised for nonoperated patients whose last episode of TIA was longer than 12 months ago.
D000925:Anticoagulants / Q000627:therapeutic use; D001241:Aspirin / Q000627:therapeutic use; D001792:Blood Platelets / Q000187:drug effects; D002339:Carotid Arteries / Q000601:surgery; D002986:Clinical Trials as Topic; D004176:Dipyridamole / Q000627:therapeutic use; D004311:Double-Blind Method; D004691:Endarterectomy; D006801:Humans; D002546:Ischemic Attack, Transient / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D010919:Placebos; D013442:Sulfinpyrazone / Q000627:therapeutic use
D000925:Anticoagulants; D010919:Placebos; D004176:Dipyridamole; D001241:Aspirin; D013442:Sulfinpyrazone