Experimental pyelonephritis induced by L-forms of Proteus mirabilis in rats.
Pyelonephritis was produced in 75 white rats by applying a 24-hour ligature on the ureter and by intravenous injection of a suspension of 5X10(9) cells of a stable Proteus mirabilis L-form. Pyelonephritis was proved microscopically in 44% of the animals. The revertants of the introduced L-form play an etiological role in the development of the infection. The stability of the pathohistological findings makes this model suitable for the purpose of experimental chemotherapy.
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D005839:Gentamicins / Q000627:therapeutic use; D007740:L Forms; D011513:Proteus mirabilis; D011704:Pyelonephritis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D051381:Rats
D005839:Gentamicins