A case of Creutzfeldt-Jakob disease.
The case is reported of a 64-year-old woman with ataxia and dementia progressing to a state of extrapyramidal rigidity and death in 10 months. The neuropathological changes characterised by severe nerve cell degeneration and loss, a hypertrophic astrocytic gliosis and a status spongiosus were widespread in the cerebral cortex, corpus striatum and cerebellum and confirmed the clinical diagnosis of Creutzfeldt-Jakob disease.
D001921:Brain / Q000473:pathology*; D002421:Caudate Nucleus / Q000473:pathology; D002531:Cerebellum / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology; D007562:Creutzfeldt-Jakob Syndrome / Q000473:pathology*; D005260:Female; D005911:Gliosis; D006801:Humans; D008875:Middle Aged; D011689:Purkinje Cells