Trial of a new analogue of LH-RH in normal subjects and in cases of anovulatory sterility.
A new and potent analogue of luteinizing hormone releasing-hormone (LH-RH), the des-gly-6-D-trypt-LH-RH which was synthesized in 1975 by Schally and his group, was assessed in normal volunteers, both men and women and in six cases of anovulatory sterility. The new substance seems to be one of the most active FSH and LH releasing factors. Its effect is stronger in the female than in the male, acting more actively on LH than FSH release. The magnitude of the effect is greater not only in amount but also in time, the levels of gonadotrophins after the injection being higher and remaining much longer. This last property, makes the new substance specially suitable for the treatment of anovulatory sterility. Of six sterile women, one ovulated and two became pregnant.
D000293:Adolescent; D000328:Adult; D000858:Anovulation / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D012737:Sex Factors
D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone