title: Ascorbic acid, neutrophil function, and the immune response.
abstract: The role of ascorbic acid is reviewed with regard to antimicrobial activity, interferon production, and humoral and cellular immune responses. Ascorbic acid appears to play a role in a number of neutrophil functions including increased chemotaxis, increased particulate ingestion, enhanced lysozyme-mediated non-oxidative killing, protection against the toxic effects of superoxide anion radical, inhibition of the halide-peroxide-myeloperoxidase system without a pronounced bactericidal effect, and stimulation of the hexose monophosphate shunt.
mesh_terms: D000818:Animals; D000917:Antibody Formation; D001205:Ascorbic Acid / Q000097:blood / Q000494:pharmacology / Q000502:physiology*; D001419:Bacteria; D002634:Chemotaxis, Leukocyte; D006600:Hexosephosphates / Q000097:blood; D006801:Humans; D007111:Immunity, Cellular; D007372:Interferons / Q000096:biosynthesis*; D007958:Leukocyte Count; D009247:NADH, NADPH Oxidoreductases / Q000097:blood; D009504:Neutrophils / Q000201:enzymology / Q000276:immunology* / Q000502:physiology*; D010545:Peroxides / Q000097:blood; D010587:Phagocytosis
chemical_list: D006600:Hexosephosphates; D010545:Peroxides; D007372:Interferons; D009247:NADH, NADPH Oxidoreductases; D001205:Ascorbic Acid