[Effects of gamma-oryzanol on gastric secretions in rats (author's transl)].
gamma-Oryzanol has been reported to inhibit gastric secretion and experimental ulcers in rats. In this paper, the inhibitory effects of gamma-oryzanol on gastric secretions caused by three stimulants have been compared. gamma-Oryzanol was slightly effective for histamine-stimulated acid secretion, non effective for carbachol-stimulated secretion and significantly inhibited the tetragastrin-stimulated secretion. The effect of gamma-oryzanol on acid secretion stimulated by tetragastrin was prevented by vagotomy but not by splanchnicotomy. It is assumed that the gastric antisecretory effect of gamma-oryzanol is mediated by the vagus nerve which plays a role in the action of gastrin.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002217:Carbachol / Q000037:antagonists & inhibitors; D005750:Gastric Juice / Q000378:metabolism*; D005755:Gastrins / Q000037:antagonists & inhibitors; D006633:Histamine Antagonists; D008297:Male; D008785:Metiamide / Q000494:pharmacology; D010434:Pepsin A / Q000378:metabolism; D010666:Phenylpropionates / Q000494:pharmacology*; D051381:Rats; D013153:Splanchnic Nerves / Q000601:surgery; D014628:Vagotomy
D005755:Gastrins; D006633:Histamine Antagonists; D010666:Phenylpropionates; D008785:Metiamide; D001285:Atropine; D002217:Carbachol; D010434:Pepsin A