[Unusual giant inclusions in blast cells during acute transformation of chronic myeloid leukemia. Cytochemical and ultrastructural study (author's transl)].
Unusual giant inclusions are reported in the blast cells during the blastic crisis of a chronic granulocytic leukemia. These inclusions coudl have their origin in degenerated mitochondria, and acid phosphatase positivity suggests fusion with lysosomes. A possible viral etiology is discussed.
D000135:Acid Phosphatase / Q000378:metabolism; D000368:Aged; D001853:Bone Marrow / Q000648:ultrastructure; D001854:Bone Marrow Cells; D003593:Cytoplasm / Q000648:ultrastructure; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000648:ultrastructure*; D008297:Male; D010544:Peroxidases / Q000378:metabolism
D010544:Peroxidases; D000135:Acid Phosphatase
Inclusions anormales dans les blastes b'une transformation aiguë de leucémie myéloïde chronique. Etude cytologique et ultrastructurale.