Immediate and middle-term cardiorespiratory effects of positive end-expiratory pressure in thirteen cases of non-haemodynamic pulmonary oedema.
Thirteen patients with severe acute respiratory failure were ventilated with positive end-expiratory pressure (PEEP) for 9 days. Haemodynamic measurements were performed after 15 min during 100% oxygen breathing, first with intermittent-positive pressure ventilation, secondly with positive end-expiratory pressure. The latter improved the Pa, O2 from 89 to 150 torr, decreased the QS/QT from 43% to 32% and decreased the Pa, CO2 from 37 to 34 torr; this improvement in gas exchange was accompanied by a decrease in cardiac index from 4.4 to 3.7 1 min-1m-2 without changing the systemic arterial pressure. Despite this beneficial effect on arterial blood oxygenation, it did not improve the survival rate of patients with severe acute respiratory failure.
D000328:Adult; D001794:Blood Pressure; D002302:Cardiac Output; D006439:Hemodynamics; D006801:Humans; D007384:Intermittent Positive-Pressure Breathing; D008176:Lung Volume Measurements; D010100:Oxygen / Q000097:blood; D011175:Positive-Pressure Respiration; D011654:Pulmonary Edema / Q000503:physiopathology / Q000628:therapy*; D014692:Ventilation-Perfusion Ratio
D010100:Oxygen