The cellular basis of allograft rejection in vivo. I. The cellular requirements for first-set rejection of heart grafts.
The nature of the cells required for first-set graft rejection in vivo was examined by using an adoptive transfer system to restore heart-graft rejection in irradiated rats. Highly purified inocula of peripheral T lymphocytes were shown to quantitatively account for the restorative ability of adoptively transferred cells. These T cells were shown to be long-lived small lymphocytes which are not recently derived from the thymus during adult life. They belong to the pool of T cells which constantly recirculate from blood to lymph as shown by their rapid appearance in the lymph of iradiated syngeneic rats after intravenous injection. Neither B lymphocytes nor antibodies in the circulation or in the graft itself are required for first-set graft rejection.
D001402:B-Lymphocytes / Q000276:immunology*; D002465:Cell Movement; D002470:Cell Survival; D003602:Cytotoxicity, Immunologic; D005720:Gamma Rays; D006084:Graft Rejection / Q000528:radiation effects; D016027:Heart Transplantation; D008198:Lymph Nodes / Q000276:immunology; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology; D014184:Transplantation, Homologous