Experiments on prevention of the endotoxin-abortifacient effect by radiodetoxified endotoxin pretreatment in rats.
Endotoxemia has been induced in pregnant rats by intravenous injection of 1 mg Escherichia coli endotoxin which resulted in intrauterine death and abortion of fetuses in 24 h. The abortifacient effect of endotoxin was prevented in 90% by 200 microgram radiodetoxified endotoxin, injected intravenously 24 h earlier. The authors suppose that the radiodetoxified endotoxin can be a good tool also in the prevention of human septic (endotoxin) shock in pregnancy.
D000019:Abortifacient Agents; D000022:Abortion, Spontaneous / Q000139:chemically induced*; D000818:Animals; D004361:Drug Tolerance; D004731:Endotoxins / Q000008:administration & dosage / Q000528:radiation effects; D004926:Escherichia coli; D005260:Female; D011247:Pregnancy; D051381:Rats; D012772:Shock, Septic / Q000517:prevention & control
D000019:Abortifacient Agents; D004731:Endotoxins