A statistical procedure useful in evaluating time of onset and termination of response in clinical trials.
A statistical model jointly characterizing the onset and termination of treatment response of a subject over a fixed observed time period is presented. The model requires that the observations for each subject are made at a set of pre-selected time points during the observed time period. A useful index characterizing the probability of being in response is developed along with maximum likelihood estimates and variances. A likelihood ratio test is developed to simultaneously compare two treatment groups with respect to this index for all times. The proposed procedure is applied to a set of data from a clinical trial of two bronchodilator drugs from which our procedure is motivated.
D001993:Bronchodilator Agents / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000188:drug therapy; D012107:Research Design; D013223:Statistics as Topic; D013997:Time Factors
D001993:Bronchodilator Agents