Autoantibodies detected in rabbits hyperimmunized with group A, C, and G streptococcal vaccines.
Rabbits hyperimmunized with group A, C, and G streptococcal vaccines developed autoantibodies with affinities for different tissues (smooth muscle, cytoplasmic, and myocardial antibodies) and for autologous proteins (anti-albumin and anti-immunoglobulin antibodies). The presence of anti-albumin and smooth muscle antibodies, associated with a high level of immunoglobulin, suggests the development of hepatic disorders in the hyperimmunized rabbits.
D000818:Animals; D000906:Antibodies; D000888:Antibodies, Anti-Idiotypic; D000907:Antibodies, Bacterial; D001323:Autoantibodies; D001428:Bacterial Vaccines; D004912:Erythrocytes / Q000276:immunology; D007117:Immunization, Secondary; D007074:Immunoglobulin G; D009130:Muscle, Smooth / Q000276:immunology; D011817:Rabbits; D012709:Serum Albumin / Q000276:immunology; D013297:Streptococcus pyogenes / Q000276:immunology*
D000906:Antibodies; D000888:Antibodies, Anti-Idiotypic; D000907:Antibodies, Bacterial; D001323:Autoantibodies; D001428:Bacterial Vaccines; D007074:Immunoglobulin G; D012709:Serum Albumin