[The problem of anti-lung basal membrane immunity in the framework of allogenic lung transplant rejection].
This study is concerned with the significance of autoimmune processes caused by the damage of lung tissue after lungallo- and autotransplantation. In 15 mongrel dogs a left side lung-allotranplantation was performed, 5 of them were treated with immunsuppressive therapy in the posttransplantation period. A group of 5 dogs with autotransplantation of the left lung served as a control-group. In the posttransplantation period the development of humoral antibodies responding with lung basal membrane antigens was examined by daily taken sera as well as by elution of immuneglobulins from the rejected grafts in the passive hemagglutination and compared with the development of alloantibodies against donor-lung's tissue. Besides of regularly traceable humoral alloantibodies of lung allograft recipients in the posttransplantation period, in no group antilung basal membrane antibodies could be found.
D000818:Animals; D000917:Antibody Formation; D001323:Autoantibodies; D001327:Autoimmune Diseases / Q000517:prevention & control; D001485:Basement Membrane / Q000276:immunology; D004285:Dogs; D006084:Graft Rejection; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016040:Lung Transplantation; D014184:Transplantation, Homologous
D001323:Autoantibodies; D007166:Immunosuppressive Agents
Zur Problematik der Antilungenbasalmenbran-Immunität im Rahmen der allogenen Lungentransplantatabstossung.