title: [Interaction between antihypertensive agents and psychotropic drugs (author's transl)].
abstract: The present review paper is dealing with the interaction between antihypertensive agents and various psychotropic drugs. Various psychotropic drugs enhance certain-side-effects of the antihypertensive substances, like sedation, extrapyramidal disorders and orthostatic hypotension. On the other hand, the blood-pressure lowering effect of clonidine, guanethidine and related drugs, and possibly also that of alpha-methy-dopa is reduced by phenothiazine-neuroleptics and tricyclic antidepressants (thymoleptics), but not by benzodiazepine tranquilizers or by butyrophenone-like neuroleptics. The pharmacological background and the clinical relevance of these interaction phenomena are discussed.
mesh_terms: D000959:Antihypertensive Agents / Q000009:adverse effects / Q000494:pharmacology*; D002490:Central Nervous System / Q000187:drug effects; D004347:Drug Interactions; D005116:Extrapyramidal Tracts / Q000502:physiology; D006145:Guanethidine / Q000494:pharmacology; D006801:Humans; D011619:Psychotropic Drugs / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D000959:Antihypertensive Agents; D011619:Psychotropic Drugs; D006145:Guanethidine
vernacular_title: Wechselwirkungen Zwischen Antihypertensiva und Psychopharmaka.