Ethanol: modifications of acute intoxication by divalent cations.
Calcium, other divalent cations, and calcium antagonists were tested for their ability to alter ethanol-induced sleeping time, hypothermia, and behavioral intoxication in mice and rats. Calcium given intraventricularly significantly enhanced sleeping time and behavioral intoxication in a dose-related manner. The ionophores X537A and A23187 accentuated the effect of a low dose of calcium, whereas the calcium chelators EDTA and EGTA decreased sleeping time. Calcium also enhanced tertiary butanol- and chloral hydrate-induced sleeping time. The effects of cations on ethanol-induced hypothermia were less significant. The results suggest the existence of a central calcium pool that is involved in ethanol intoxication in rodents.
D000435:Alcoholic Intoxication / Q000503:physiopathology*; D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects; D000001:Calcimycin / Q000494:pharmacology; D002118:Calcium / Q000037:antagonists & inhibitors / Q000502:physiology*; D002413:Cations, Divalent; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D005260:Female; D006801:Humans; D007832:Lasalocid / Q000494:pharmacology; D008297:Male; D051379:Mice; D009068:Movement / Q000187:drug effects; D051381:Rats
D002413:Cations, Divalent; D000001:Calcimycin; D002118:Calcium; D007832:Lasalocid