Efficacy of co-trimoxazole in infantile gastro-enteritis.
A comparative, randomized trial was carried out in 105 children, aged between 2 months and 2 years and who were suffering from acute gastro-enteritis, to assess the effectiveness of co-trimoxazole with that of streptomycin and neomycin. Patients were treated in hospital for 5 days or longer and received daily doses either of 50 mg/kg streptomycin or neomycin, or of 6 mg trimethoprim plus 30 mg sulphamethoxazole/kg. Clinical and bacteriological assessments of response to treatment showed that better results were achieved in the co-trimoxazole group, and the duration of illness was also shorter in this this group. In the 3 patients on neomycin and the 12 on streptomycin who did not respond clinically, symptoms were controlled in all of them within 2 to 3 days of being changed over to co-trimoxazole treatment.
D002675:Child, Preschool; D002986:Clinical Trials as Topic; D004338:Drug Combinations; D005260:Female; D005759:Gastroenteritis / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D007223:Infant; D008297:Male; D009355:Neomycin / Q000627:therapeutic use; D013307:Streptomycin / Q000627:therapeutic use; D013420:Sulfamethoxazole / Q000627:therapeutic use*; D014295:Trimethoprim / Q000627:therapeutic use*
D004338:Drug Combinations; D014295:Trimethoprim; D009355:Neomycin; D013420:Sulfamethoxazole; D013307:Streptomycin