Comparative blanching activities of proprietary diflucortolone valerate topical preparations.
The blanching activities and hence bioavailabilities of the cream, ointment and fatty ointment preparations of Nerisone and Temetex (diflucortolone valerate 0.1%) were evaluated using an occluded and unoccluded blanching assay. These products were compared to Synalar ointment and cream (fluocinolone acetonide 0.025%), established topical corticosteroid preparations. Statistical analysis showed no significant differences between similar formulations of diflucortolone valerate. Significant differences were noted between diflucortolone valerate and fluocinolone acetonide preparations.
D000287:Administration, Topical; D001682:Biological Availability; D002986:Clinical Trials as Topic; D004060:Diflucortolone / Q000031:analogs & derivatives; D005446:Fluocinolone Acetonide / Q000008:administration & dosage* / Q000494:pharmacology; D005448:Fluocortolone / Q000008:administration & dosage* / Q000031:analogs & derivatives / Q000494:pharmacology; D006801:Humans; D009824:Ointments; D014677:Pharmaceutical Vehicles; D011244:Pregnadienediols / Q000008:administration & dosage*; D012867:Skin / Q000187:drug effects*; D013810:Therapeutic Equivalency
D009824:Ointments; D014677:Pharmaceutical Vehicles; D011244:Pregnadienediols; D005446:Fluocinolone Acetonide; C013486:diflucortolone valerate; D005448:Fluocortolone; D004060:Diflucortolone