title: The pharmacology of amblyopia.
abstract: Physiologic and anatomic evidence has suggested an anatomic disconnection between the deprived eye and visual cortical neurons in cats made amblyopic by monocular deprivation. Clinical and visual-evoked response data suggest, however, that inhibition may play a major role in amblyopia. Accordingly, we intravenously administered anti-inhibitory compounds (bicuculline, ammonium ion, naloxone) to amblyopic cats and demonstrated a substantial restoration of binocular input to the visual cortex. Such pharmacologic reversal suggests that amblyopia is not an anatomically fixed lesion.
mesh_terms: D000328:Adult; D000550:Amblyopia / Q000188:drug therapy* / Q000209:etiology; D000613:Aminobutyrates / Q000037:antagonists & inhibitors*; D000818:Animals; D001640:Bicuculline / Q000494:pharmacology / Q000627:therapeutic use; D002415:Cats; D002648:Child; D018756:GABA Antagonists; D006801:Humans; D009270:Naloxone / Q000494:pharmacology / Q000627:therapeutic use; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology / Q000627:therapeutic use; D012683:Sensory Deprivation; D014785:Vision, Ocular / Q000187:drug effects*; D014792:Visual Acuity; D014793:Visual Cortex / Q000187:drug effects
chemical_list: D000613:Aminobutyrates; D018756:GABA Antagonists; D000644:Quaternary Ammonium Compounds; D009270:Naloxone; D001640:Bicuculline