title: Double blind study of milk lactose intolerance.
abstract: One hundred and fifty subjects were studied in a double blind fashion to determine the relationship between lactose malabsorption and milk lactose intolerance. Each participant received 250 ml of a different type of milk on 3 consecutive days. Milk A contained no lactose, milk B had 12.5 g, and milk C contained 37.5 g of lactose. After the experiment was completed each subject was classified with a lactose tolerance test as having "sufficient" or "insufficient" lactase activity. Milk A produced no gastrointestinal symptoms in either sufficient or in insufficient persons. Milk B produced symptoms in 3.8% of sufficient and 37.1% of insufficient individuals, and Milk C induced symptoms in 7.6% of sufficient and 83.5% of insufficient subjects. These differences are very highly significant (P less than 0.0001). It is concluded that lactose-intolerant subjects are indeed milk-intolerant and that the frequency with which symptoms occur in persons with lactose malabsorption increases in direct relation to the lactose content of the milk.
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D007785:Lactose / Q000378:metabolism*; D007787:Lactose Intolerance / Q000378:metabolism*; D007789:Lactose Tolerance Test; D008286:Malabsorption Syndromes / Q000150:complications; D008297:Male; D008875:Middle Aged; D008892:Milk
chemical_list: D007785:Lactose