Clinical reactions to an adsorbed killed trivalent influenza vaccine (including A/New Jersey 8/76 antigen) with different immunization methods.
The local and general reactions of 489 individuals vaccinated with an adsorbed killed influenza vaccine (containing A/New Jersey 8/76, A/Victoria 3/75, B/Hong kong 8/73 antigens) were studied on the fourth day after vaccination. 179 participants were vaccinated by syringe, the rest by jet injector. Local indurations were observed in 7.3% of participants injected by needle versus 14.1% to 19.5%, respectively in individuals immunized with two different jet guns (Lodi, Scherer). 2 ulcerations on the injection site were found in the jet group. Complaints about local sensations were much fewer in the group injected by needle (2.8%) than in the groups injected by jet injectors (11.8-14.1%). Postvaccinal systemic reactions were similar (between 8.5-11.2%) in both groups. Febrile reactions were altogether low (2.8%).
D000293:Adolescent; D000328:Adult; D001831:Body Temperature; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D006801:Humans; D009980:Influenza A virus / Q000276:immunology; D007252:Influenza Vaccines / Q000008:administration & dosage* / Q000009:adverse effects; D007273:Injections, Intramuscular / Q000009:adverse effects; D007277:Injections, Jet / Q000009:adverse effects; D008875:Middle Aged; D014611:Vaccination / Q000379:methods*
D007252:Influenza Vaccines