title: A review of experimental models for studying the tissue penetration of antibiotics in man.
abstract: Measurement of tissue antibiotic levels is of great importance in developing rational treatment for infection, particularly in patients whose host defense systems are compromised. This review outlines some of the main approaches to this problem, giving examples of the application of the new techniques in different clinical situations.
mesh_terms: D000900:Anti-Bacterial Agents / Q000378:metabolism* / Q000627:therapeutic use; D001424:Bacterial Infections / Q000188:drug therapy* / Q000378:metabolism; D001768:Blister / Q000378:metabolism; D005110:Extracellular Space / Q000032:analysis; D005122:Exudates and Transudates / Q000032:analysis; D006801:Humans; D008722:Methods; D008826:Microbial Sensitivity Tests; D008954:Models, Biological; D012884:Skin Window Technique; D013048:Specimen Handling; D013183:Sputum / Q000032:analysis; D014018:Tissue Distribution
chemical_list: D000900:Anti-Bacterial Agents