Bacterial radiosensitization by 8-methoxypsoralen.
8-Methoxypsoralen has been shown to act as a radiosensitizer of hypoxic bacterial cells with uvrA, recA and uvrB and/or lexA mutations. No effect of the drug on the radiosensitivity of oxic bacteria with these mutations was observed. This drug differs from O2 and electron-affinic radiosensitizers in that its effect is not purely dose-modifying and can exceed the oxygen effect in certain mutants.
D004307:Dose-Response Relationship, Radiation; D004583:Electrons; D004926:Escherichia coli / Q000528:radiation effects*; D008730:Methoxsalen / Q000494:pharmacology; D009154:Mutation; D010100:Oxygen; D011836:Radiation Tolerance; D011838:Radiation-Sensitizing Agents
D011838:Radiation-Sensitizing Agents; D010100:Oxygen; D008730:Methoxsalen