Treatment of urogenital/rectal gonorrhoea in males and females with epicillin in combination with probenecid.
This paper describes the results of treatment of 124 patients (78 male and 46 female) with urogenital/rectal gonorrhoea with epicillin (3.5 g orally) in combination with 1 g of probenecid (instant therapy). High cure rates were found for both the male (98.6%) and female patients (100%). Serious drawbacks of this treatment are a high frequency of postgonococcal urethritis (45.6%) and a short-lived increase in the frequency and looseness of faecal discharge in a considerable amount of patients (6.8% in the male and 22.7% in the female patients).
D000284:Administration, Oral; D000667:Ampicillin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D005831:Genital Diseases, Female / Q000188:drug therapy*; D005832:Genital Diseases, Male / Q000188:drug therapy*; D006069:Gonorrhea / Q000188:drug therapy*; D006801:Humans; D008297:Male; D011339:Probenecid / Q000008:administration & dosage / Q000627:therapeutic use*; D012002:Rectal Diseases / Q000188:drug therapy*
D000667:Ampicillin; D011339:Probenecid