title: Studies on parasitic crisis in malaria: I. Signs of impending crisis in Plasmodium berghei infections of the white rat.
abstract: White rats infected with Plasmodiam berghei were observed throughout the course of infection for indicators of impending crisis (penultimate stage). Two ratios, percentage young compact forms:percentage trophozoites and percentage reticulocytes:percentage parasitaemia, were reliable markers of the penultimate period and impending crisis. When the percentage young compact form:percentage trophozoite ratio exceeded 1.0 and was coincident with an increase of uninfected reticulocytes in the circulation (as given by a percentage reticulocyte:percentage parasitaemia ratio greater than 1.0) the parasitaemic decline of crisis consistently occurred 24-48 hours later.
mesh_terms: D000818:Animals; D001769:Blood / Q000469:parasitology; D004906:Erythrocyte Count; D008288:Malaria / Q000469:parasitology*; D010962:Plasmodium berghei / Q000254:growth & development; D051381:Rats; D012156:Reticulocytes / Q000469:parasitology