A double-blind clinical trial of a guanethidine/adrenaline combination, compared with the two separate components, in glaucoma.
In a double-blind cross-over study, the intraocular pressure-lowering action and side effects of a 5% guanethidine/1% adrenaline combination were studied and compared with those of two components alone. The subjects were 63 glaucoma patients divided into three random groups given the three preparations in a different order. The pressure-lowering effect of the combination is significantly better (P less than 1%) than that of either component alone but the side effects were more severe.
D002986:Clinical Trials as Topic; D003231:Conjunctivitis / Q000139:chemically induced; D004311:Double-Blind Method; D004338:Drug Combinations; D004341:Drug Evaluation; D004837:Epinephrine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005901:Glaucoma / Q000188:drug therapy*; D006145:Guanethidine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006261:Headache / Q000139:chemically induced; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D009883:Ophthalmic Solutions
D004338:Drug Combinations; D009883:Ophthalmic Solutions; D004837:Epinephrine; D006145:Guanethidine