[Quantitative morphological investigation of the effect of thiobutabarbitone sodium anaesthesia on the endocrine and exocrine pancreas of the albino rat (author's transl)].
In respect of controls the beta-cells of the Islets of Langerhans in fed rats showed a significant decrease in nuclear volume after 40 min of anaesthesia with Thiobutabarbitone Sodium in a double-maximum-load dose. The alpha-cells and the cells of the exocrine pancreas do not show such alteration. The reduction in beta-cell acitivity is referred to a time and dose dependent effect of narcosis on the metabolism of the beta-cells and possible membrane phenomena. According to the morphological picture the otherwise missing signs of impaired function of the cells indicate a peripheral disturbance of glucose utilization during nacrosis. The blood-sugar levels support the proposed explanation.
D000758:Anesthesia; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002467:Cell Nucleus; D007515:Islets of Langerhans / Q000187:drug effects*; D007620:Karyometry; D008297:Male; D008566:Membranes; D010179:Pancreas / Q000187:drug effects*; D051381:Rats; D013858:Thiobarbiturates / Q000494:pharmacology*; D013997:Time Factors
D001786:Blood Glucose; D013858:Thiobarbiturates
Quantitativ-morphologische Untersuchung über die Wirkung einer Narkose mit Thiobutabarbital-Natrium auf das endokrine und exokrine Pankreas der Albinoratte.