The relationship between mutagenicity and carcinogenicity of some nitrosamines.
The carcinogenicity and mutagenicity of 26 nitrosamines were compared to help validate the predictability of a short-term in vitro test. 80% of the compounds showed agreement between the two characteristics, while 20% did not. Of the latter group, 8% were false positives and 12% were false negatives.
D002273:Carcinogens; D004305:Dose-Response Relationship, Drug; D005821:Genetic Techniques; D009153:Mutagens; D009602:Nitrosamines / Q000494:pharmacology*; D012486:Salmonella typhimurium
D002273:Carcinogens; D009153:Mutagens; D009602:Nitrosamines