A mutant of the antibiotic resistance factor R124 with altered copy number.
A mutation conferring increased antibiotic resistance on Salmonella typhimurium strain 11G carrying R124 was plasmid determined; strains harbouring the mutant plasmid contained more DNA as ccc plasmid than those harbouring R124. The increased copy number was manifested at all growth rates tested.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004269:DNA, Bacterial / Q000032:analysis; D004352:Drug Resistance, Microbial; D009154:Mutation; D010957:Plasmids; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics*
D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial