Antitumor activity of hot-water extract from delipidated BCG.
The antitumor activity of hot-water extract of delipidated BCG was investigated in mice inoculated with Sarcoma-180 cells and Ehrlich carcinoma cells, respectively. The hot-water extract was found to be effective when administered after and ineffective when administered before the inoculation of tumor cells. When this extract was given with anticancer drugs, such as Mitomycin C and cyclophosphamide, a combined effect was obtained in the treatment of Sarcoma-180 and of Ehrlich carcinoma.
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D001500:BCG Vaccine; D002286:Carcinoma, Ehrlich Tumor / Q000628:therapy*; D003520:Cyclophosphamide / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006358:Hot Temperature; D007167:Immunotherapy; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008937:Mitomycins / Q000627:therapeutic use; D009163:Mycobacterium bovis / Q000032:analysis / Q000276:immunology*; D012510:Sarcoma 180 / Q000628:therapy*
D000276:Adjuvants, Immunologic; D001500:BCG Vaccine; D008937:Mitomycins; D003520:Cyclophosphamide