[Suppression of the intradermal hypersensitivity reaction of the delayed type by a serum fraction from patients containing leukocyte migration inhibition factor].
The blood serum of patients with active tuberculosis of the lungs and chronic pneumonia inhibited migration of donor's leukocytes and macrophages of the peritonal exudate of guinea pigs when compared with migration of similar cells in the medium with the serum of cattle or donors. After chromatography these sera were fractionated on the columns with Sephadex G-100. Fractions containing the leukocyte migration inhibition factor (LMIF) suppressed, up to complete abolition, the intradermal reaction to tuberculin in man and guinea pigs sensitized with BCG. The LMIF is supposed to act in the regulation of delayed hypersensitivity reaction.
D000818:Animals; D001500:BCG Vaccine; D002908:Chronic Disease; D006168:Guinea Pigs; D006801:Humans; D008263:Macrophage Migration-Inhibitory Factors / Q000097:blood* / Q000494:pharmacology; D011014:Pneumonia / Q000276:immunology*; D012867:Skin / Q000187:drug effects / Q000276:immunology*; D014374:Tuberculin Test; D014397:Tuberculosis, Pulmonary / Q000276:immunology*
D001500:BCG Vaccine; D008263:Macrophage Migration-Inhibitory Factors
Ugnetenie vnutrikozhnoĭ reaktsii giperchuvstvitel'nosti zamedlennogo tipa fraktsieĭ syvorotki krovi bol'nykh, soderzhashcheĭ faktor podavleniia migratsii leĭkotsitov.