beta-Lipotropin in brain: localization in hypothalamic neurons by immunoperoxidase technique.
beta-Lipotropin (beta-LPH) has been localized in hypothalamus and pituitary of sheep and ox by the immunoperoxidase technique. In both species beta-LPH was found in perikarya of arcuate neurons as well as in cells of the anterior and intermediate lobes of the pituitary. A large number of immunoreactive axons were found in the arcuate region; some appeared to innervate other neurons and others projected to portal capillaries. Stained fiber segments were also scattered throughout the hypothalamus. The presence of beta-LPH in hypothalamic neurons supports the possibility that brain beta-LPH may be a precursor for opiate-like or other peptides which may be involved in neuromodulation or neurohormonal activities.
D000818:Animals; D001369:Axons / Q000032:analysis; D002196:Capillaries; D002417:Cattle; D005260:Female; D007031:Hypothalamus / Q000032:analysis*; D007124:Immunoenzyme Techniques; D008297:Male; D009474:Neurons / Q000032:analysis; D010903:Pituitary Gland, Anterior / Q000032:analysis / Q000098:blood supply; D012756:Sheep; D008083:beta-Lipotropin / Q000032:analysis*
D008083:beta-Lipotropin