Methylene blue as an inhibitor of stone formation.
Kinetics of growth and dissolution of calcium oxalate monohydrate were examined in the presence of small concentrations of methylene blue. The data presented show moderate retardation in growth and dissolution rates. It was also found that methylene blue decreased the decalcification rate of calcium oxalate renal calculi. The implications of these findings in the treatment of urolithiasis are discussed.
D002118:Calcium / Q000037:antagonists & inhibitors*; D003460:Crystallization; D003648:Decalcification Technique; D006801:Humans; D007669:Kidney Calculi / Q000188:drug therapy / Q000517:prevention & control*; D008751:Methylene Blue / Q000494:pharmacology* / Q000627:therapeutic use; D010070:Oxalates / Q000037:antagonists & inhibitors*; D012995:Solubility
D010070:Oxalates; D002118:Calcium; D008751:Methylene Blue