Visualization of tubulin in lymphocytes. I. Comparison of normal and chronic lymphocytic leukemia (CLL) lymphocytes.
Cell structures containing tubulin were studied in peripheral blood lymphocytes from 8 normal donors and 11 patients with CLL using specific antitubulin antibodies revealed by immunoperoxidase assay. The centriole and microtubules were clearly visible in both groups. A "nucleus-associated tubulin-containing structure" was revealed by antitubulin antibodies and was found in virtually all lymphocytes of normal subjects but in a considerably lower number of CLL lymphocytes. The nature of this structure and its relationship to other cell structures are discussed.
D000328:Adult; D000368:Aged; D000906:Antibodies; D005260:Female; D005455:Fluorescent Antibody Technique; D006023:Glycoproteins; D006801:Humans; D007945:Leukemia, Lymphoid / Q000097:blood*; D008214:Lymphocytes; D008297:Male; D008875:Middle Aged; D014404:Tubulin / Q000276:immunology
D000906:Antibodies; D006023:Glycoproteins; D014404:Tubulin