Postinfarction exercise capacity after lidoflazine treatment or physical training.
44 male postinfarction volunteers were divided into 4 groups and submitted to performance tests. Groups I and II consisted of 24 patients, 12 of whom followed a 2-month physical training program, while the other 12 served as controls. Groups III and IV (10 patients each) were included in a 10-month double-blind crossover study with lidoflazine 240 mg/day vs. placebo. The cardiovascular adaptation of the patients treated for 5 months with lidoflazine had two features in common with that observed after 2 months of physical training, namely an increase in maximal exercise capacity and, during submaximal exercise tests, a decrease in heart rate compensated for by an increase in stroke volume. In contrast to physical training, treatment with lidoflazine did not improve the peripheral oxygen consumption by the muscles.
D001794:Blood Pressure; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004341:Drug Evaluation; D005080:Exercise Test; D006339:Heart Rate; D006439:Hemodynamics; D006801:Humans; D008013:Lidoflazine / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy / Q000503:physiopathology / Q000534:rehabilitation*; D010101:Oxygen Consumption; D010806:Physical Education and Training; D005082:Physical Exertion; D010879:Piperazines / Q000627:therapeutic use*; D010919:Placebos
D010879:Piperazines; D010919:Placebos; D008013:Lidoflazine