Pathologic localization of Tamm-Horsfall protein in interstitial deposits in renal disease.
Interstitial periodic acid-Schiff positive deposits of amorphous or fibrillar material were observed in 32% of kidneys with a variety of tubulointerstitial diseases, including medullary cystic disease (60%), chronic pyelonephritis (20%), and hydronephrosis (33%). Immunofluorescent staining for Tamm-Horsfall protein showed interstitial localization of this protein which was identical in distribution, shape, size, and fine detail with the periodic acid-Schiff positive deposits. The deposits appeared to originate from disrupted tubules and were sometimes surrounded by inflammatory infiltrate. The intrarenal localization of Tamm-Horsfall protein outside of distal tubules in pathologic states indicates that this protein may have a role in the pathogenesis of renal disease.
D005455:Fluorescent Antibody Technique; D005921:Glomerulonephritis / Q000378:metabolism; D006023:Glycoproteins / Q000378:metabolism*; D006652:Histological Techniques; D006801:Humans; D006869:Hydronephrosis / Q000378:metabolism; D007163:Immunosorbent Techniques; D007668:Kidney / Q000378:metabolism*; D007674:Kidney Diseases / Q000378:metabolism*; D052177:Kidney Diseases, Cystic / Q000378:metabolism; D007684:Kidney Tubules / Q000378:metabolism; D009395:Nephritis, Interstitial / Q000378:metabolism; D010503:Periodic Acid-Schiff Reaction; D007690:Polycystic Kidney Diseases / Q000378:metabolism; D011704:Pyelonephritis / Q000378:metabolism; D012189:Retrospective Studies
D006023:Glycoproteins