title: Salicylate sensitivity in children reported to respond to salicylate exclusion.
abstract: Twelve children, aged six to 13 years, whose parents reported an improvement in behavioural problems with use of the Feingold (K-P) diet for an average period of 12 months, were challenge-tested with 40 mg of acetylsalicylic acid in a double-blind, cross-over trial with ascorbic acid as a placebo. The children were tested within three hours of ingestion of either the experimental or placebo tablet with a battery of psychological and neurological tests, and were rated by a parent on an enlarged Conners' Parent-Teacher Questionnaire for four days after the ingestion of the tablet. It was found that significance was reached in tests of general cognitive capacity, line walking and the "finger-to-nose" tests, as well as increased disturbance in sleep patterns in these children.
mesh_terms: D000293:Adolescent; D000485:Allergens / Q000008:administration & dosage; D001205:Ascorbic Acid; D001241:Aspirin / Q000008:administration & dosage / Q000009:adverse effects*; D002648:Child; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004342:Drug Hypersensitivity / Q000178:diet therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006948:Hyperkinesis / Q000139:chemically induced* / Q000178:diet therapy; D008297:Male; D010919:Placebos; D011795:Surveys and Questionnaires
chemical_list: D000485:Allergens; D010919:Placebos; D001205:Ascorbic Acid; D001241:Aspirin