Gonadal dysgenesis with adenocarcinoma of the endometrium: an electron microscopic and steroid receptor analyses with a review of the literature.
A patient with gonadal dysgenesis who developed endometrial carcinoma in her 31st year of estrogen therapy is discussed in relation to thirteen previously reported cases of carcinoma of the uterus in patients with Turner's syndrome. The pattern of steroid receptor proteins in the endometrial carcinoma was found to correlate with the degree of differentiation of the tumor as assessed by light and electron microscopy. The findings reflect a potential for continued hormonal responsiveness of the tumor.
D000230:Adenocarcinoma / Q000150:complications* / Q000378:metabolism / Q000648:ultrastructure; D045166:Estradiol Congeners / Q000009:adverse effects; D005260:Female; D006801:Humans; D008854:Microscopy, Electron; D008875:Middle Aged; D011987:Receptors, Steroid; D014424:Turner Syndrome / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D014594:Uterine Neoplasms / Q000150:complications* / Q000378:metabolism / Q000648:ultrastructure
D045166:Estradiol Congeners; D011987:Receptors, Steroid