In vivo effects of Escherichia coli endotoxin on sulfobromophthalein clearance in the guinea-pig.
In vivo studies indicated that the primary effects of E. coli endotoxin on hepatic clearance of sulfobromophthalein were at the excretory level. Newborns were more sensitive to the LPS than older animals.
D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D001219:Aspartate Aminotransferases / Q000097:blood; D004731:Endotoxins / Q000494:pharmacology*; D004926:Escherichia coli; D005260:Female; D006168:Guinea Pigs; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D013448:Sulfobromophthalein / Q000378:metabolism*
D004731:Endotoxins; D013448:Sulfobromophthalein; D001219:Aspartate Aminotransferases