Hygrophotographic technique for testing local antiperspirant activity.
Bilateral stopping of plantar perspiration in the mouse was obtained by application of a cotton-wool swab soaked in a 3% solution of BRL 556 in 60% ethanol for 1--2 min to the plantar surface of its right hind paw. For humans, aerosols which are at present on the market produce a sensible reduction in palmar sweating. The effect was recorded and illustrated by a modified hygrophotographic technique in which the sweat, released in the form of water vapor, was recorded by the hygrophotographic film, without any contact with the skin. In the mouse, the recording was carried out by the application to the plantar surface of a piece of hygrophotographic film, by the aid of an adhesive tape.
D000287:Administration, Topical; D000336:Aerosols; D000818:Animals; D002986:Clinical Trials as Topic; D003510:Cyclohexanes / Q000008:administration & dosage / Q000494:pharmacology; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D005528:Foot; D006024:Glycopyrrolate / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology*; D006614:Hindlimb; D006801:Humans; D051379:Mice; D010781:Photography; D011759:Pyrrolidines / Q000494:pharmacology*; D013546:Sweating / Q000187:drug effects*
D000336:Aerosols; D003510:Cyclohexanes; D011759:Pyrrolidines; C016852:oxypyrronium bromide; D006024:Glycopyrrolate