Psoriasis treated with clobetasol propionate and photochemotherapy.
Comparable lesions in 16 patients with chronic plaque psoriasis were treated with clobetasol propionate or placebo ointments for 1 week before beginning photochemotherapy. The greater improvement of the steroid treated lesions was maintained after the ointment was withdrawn and there was a mean period of 31 days before those treated with placebo showed a comparable response to photochemotherapy. By the end of the study 8 patients were completely free of psoriasis, healing being achieved after a mean of 7.2 photochemotherapy treatments on the steroid treated lesions compared with 13.5 where a placebo ointment was used. No patient had any adverse reaction to treatment.
D000328:Adult; D001623:Betamethasone / Q000031:analogs & derivatives*; D002986:Clinical Trials as Topic; D002990:Clobetasol / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008730:Methoxsalen / Q000627:therapeutic use*; D010778:Photochemotherapy; D010919:Placebos; D011565:Psoriasis / Q000188:drug therapy / Q000628:therapy*
D010919:Placebos; D001623:Betamethasone; D002990:Clobetasol; D008730:Methoxsalen