Effect of haloperidol and d-amphetamine on cerebral tyramine and octopamine levels.
The administration of d-amphetamine or haloperidol produced a marked reduction in the rat striatum concentration of p-tyramine, an effect that was not observed in the mesolimbic system. However, the administration of d-amphetamine to haloperidol-pretreated animals produced in both brain areas a marked reduction in p-tyramine levels. Furthermore, this latter treatment produced a marked increase in the m-tyramine levels in both brain regions. Hypothalamic p-octopamine levels were reduced by d-amphetamine, but not by haloperidol or haloperidol in the presence of d-amphetamine.
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D003913:Dextroamphetamine / Q000494:pharmacology*; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D009655:Octopamine / Q000378:metabolism*; D051381:Rats; D013997:Time Factors; D014439:Tyramine / Q000378:metabolism*
D009655:Octopamine; D006220:Haloperidol; D003913:Dextroamphetamine; D014439:Tyramine