Ultrastructural lesions of muscle and immunofluorescent deposits in vessels in Reye's syndrome: a preliminary report of serial muscle biopsies.
Thirteen sequential percutaneous skeletal muscle biopsy specimens from 4 patients with Reye's syndrome were studied ultrastructurally and by direct immunofluorescence. Prominent generalized intermyofibrillar edema, mitochondrial disruption, and swelling of vascular endothelium were demonstrated in 2 patients. In all 4 patients there were granular deposits of immunoglobulins G and M in intramuscular vessels, presumably representing antigen-antibody complexes. We postulate that these changes may be pathogenetically important in this syndrome and suggest that muscle biopsy tissue be utilized for further investigation of Reye's syndrome.
D000936:Antigen-Antibody Complex; D001706:Biopsy; D001808:Blood Vessels / Q000276:immunology / Q000648:ultrastructure*; D005455:Fluorescent Antibody Technique; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008931:Mitochondria, Muscle / Q000648:ultrastructure; D008933:Mitochondrial Swelling; D009132:Muscles / Q000098:blood supply / Q000276:immunology / Q000648:ultrastructure*; D012202:Reye Syndrome / Q000276:immunology / Q000473:pathology*
D000936:Antigen-Antibody Complex; D007074:Immunoglobulin G; D007075:Immunoglobulin M