Significance of alpha-subunit HCG demonstrated in breast carcinomas by the immunoperoxidase technique.
Fifty-three breast carcinomas were examined by an indirect immunoperoxidase technique for the presence of the alpha-subunit of human chorionic gonadotrophin. Positive staining occurred in 12 (22.6%). There was no correlation between alpha-subunit production and specific histological features, but production was related to the presence of lymph node metastases and hence a poorer prognosis. The alpha-subunit could be used as a prognostic indicator in the assessment of breast carcinoma.
D001943:Breast Neoplasms / Q000032:analysis* / Q000473:pathology; D006063:Chorionic Gonadotropin / Q000032:analysis*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008207:Lymphatic Metastasis
D006063:Chorionic Gonadotropin