[Effect of prednisolone on the nucleic acid content and RNA synthesis in human lymph nodes in systemic diseases].
Studies on quantitative DNA content in lymphnode cells in patients with lymphogranulomatosis and reticulosis indicated that small prednisolon concentrations (0.1 mg/100 mg of cells) may be responsible for a reduced amount of DNA. The study of the quantitative content and turnover rate of total RNA has shown by the labeled uridine-H3 precursor incorporation a considerable decrease of RNA content and the reduce incorporation of the label in total RNA (approximately by 40% on an average).
D002986:Clinical Trials as Topic; D004273:DNA, Neoplasm / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D006689:Hodgkin Disease / Q000188:drug therapy / Q000378:metabolism*; D006801:Humans; D008198:Lymph Nodes / Q000378:metabolism*; D008206:Lymphatic Diseases / Q000188:drug therapy / Q000378:metabolism*; D008207:Lymphatic Metastasis; D008214:Lymphocytes / Q000378:metabolism; D011239:Prednisolone / Q000627:therapeutic use*; D012334:RNA, Neoplasm / Q000096:biosynthesis / Q000378:metabolism*; D014529:Uridine / Q000378:metabolism
D004273:DNA, Neoplasm; D012334:RNA, Neoplasm; D011239:Prednisolone; D014529:Uridine
Vliianie prednizolona na soderzhanie nukleinovykh kislot i sintez RNK v limfouzlakh cheloveka pri sistemnykh zabolevaniiakh.