title: The effect of high doses of vitamin B6 on autistic children: a double-blind crossover study.
abstract: The authors used data from an earlier nonblind study to identify 16 autistic-type child outpatients who had apparently improved when given vitamin B6 (pyridoxine). In a double-blind study each child's B6 supplement was replaced during two separate experimental trial periods with either a B6 supplement or a matched placebo. Behavior was rated as deteriorating significantly during the B6 withdrawal.
mesh_terms: D000293:Adolescent; D001321:Autistic Disorder / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D010919:Placebos; D011736:Pyridoxine / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D010919:Placebos; D011736:Pyridoxine