[S35 lipoic acid distribution and its effect on pyruvate dehydrogenase activity in rats with Walker carcinoma].
S35-lipoic acid injected intraperitoneally in rats with Walker carcinosarcoma in a dose of 250 mg/Kg is accumulated in their organs and tissues to much higher concentrations compared with normal animals during all terms of the observation (15 min, 1 hour, 24 hours). Differences were especially great after 24 hours. Pyruvate dehydrogenase activity in tumor rats organs was considerably reduced when calculated per 1 Kg of tissue, but it is practically unchanged when calculated per 1 mg of protein, which amount in 1 g of tissue in them is distinctly lower than in normal animals. Single injections of lipoic acid in tumor-bearing rats do restore the enzyme activity to normal (in 1 hour), while repeated ones (10 days)--prolong animals lifeterms by 25%.
D000818:Animals; D002279:Carcinoma 256, Walker / Q000378:metabolism*; D004789:Enzyme Activation / Q000187:drug effects; D005260:Female; D009368:Neoplasm Transplantation; D011768:Pyruvate Dehydrogenase Complex / Q000378:metabolism*; D051381:Rats; D013462:Sulfur Radioisotopes; D008063:Thioctic Acid / Q000008:administration & dosage / Q000378:metabolism*; D013997:Time Factors
D011768:Pyruvate Dehydrogenase Complex; D013462:Sulfur Radioisotopes; D008063:Thioctic Acid
Raspredelenie S35 lipoevoĭ kisloty i ee vliianie na aktivnost'piruvatdegidrogenazy krys s kartsinomoĭ Uokera.