title: [Ultrastructure and secretory cycle of the islands of Langerhans cells in pancreatic cancer].
abstract: By electron microscopy, the islets of Langerhans of 5 patients with cancer of the pancreas were studied. The most obvious ultrastructural changes were found in the insulin-producing B-cells. Their cytoplasm contained a reduced number of secretory granules. Many B-cells were seen at different stages of the secretory cycle, part of them being destructed. On studying secretory process, the formation and maturation of B-granules was demonstrated in the cistern of ergastoplasm without the Golgi complex being involved. The data obtained suggest the functional tensity of the insular tissue at the neoplastic process in the exocrine part of the pancreas.
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000473:pathology*; D007801:Langerhans Cells / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure*; D008854:Microscopy, Electron; D010190:Pancreatic Neoplasms / Q000473:pathology*
chemical_list: D007328:Insulin
vernacular_title: Ul'trastruktura i sekretornyĭ tsikl endokrinnykh kletok ostrovkov Langergansa pri rake podzheludochnoĭ zhelezy.