The distribution of substance P immunoreactive fibers in the rat central nervous system.
A detailed account of the distribution of immunoreactive substance P-containing structures in the rat central nervous system is presented, from results obtained by applying an indirect immunofluorescent technique. High densities of substance P-containing nerve terminals were present in sensory nuclei and other non-sensory structures such as thalamus, hypothalamus and extrapyramidal system. Substance P-reactive neuron cell bodies were present in spinal root ganglia, nucleus habenulae medialis, nucleus interpeduncularis, caudoputamen and globus pallidus. Most of the neocortex and the cerebellar cortices had no substance P-positive elements. The results support the hypothesis that substance P may be a widespread neurotransmitter in the central nervous system.
D000818:Animals; D001923:Brain Chemistry; D004027:Diencephalon / Q000032:analysis; D005455:Fluorescent Antibody Technique; D008297:Male; D008636:Mesencephalon / Q000032:analysis; D051381:Rats; D013116:Spinal Cord / Q000032:analysis; D013373:Substance P / Q000032:analysis*; D013687:Telencephalon / Q000032:analysis
D013373:Substance P