title: In vitro studies on microphage functions in chronic pyoderma vegetans.
abstract: The function of microphages has been studied in two patients with chronic pyoderma vegetans by in vitro determination of phagocytosis as well as chemotaxis. The results showed a striking decrease in the chemotactic activity of the neutrophil granulocytes, a reduced phagocytosis of Candida albicans and Staphylococcus aureus, and a weakness of the intracellular killing of these microorganisms. However, the NADH-dependent oxidase activity appeared to be intact. No defect was found in the specific cellular or humoral immune system in either patient.
mesh_terms: D000328:Adult; D002176:Candida albicans / Q000276:immunology; D002634:Chemotaxis, Leukocyte; D002908:Chronic Disease; D006801:Humans; D008297:Male; D009246:NADH Tetrazolium Reductase / Q000378:metabolism; D009504:Neutrophils / Q000201:enzymology; D009580:Nitroblue Tetrazolium; D010586:Phagocytes / Q000502:physiology*; D010587:Phagocytosis; D011711:Pyoderma / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D013211:Staphylococcus aureus / Q000276:immunology
chemical_list: D009580:Nitroblue Tetrazolium; D009246:NADH Tetrazolium Reductase