[Effect of gentamycin, decamethoxin and prodigiozan on the course and outcome of experimental pyocyanic infection in white mice].
The therapeutic and prophylactic effectiveness of gentamicin, decamethoxin and prodigiozan was determined on albino mice infected with two-fold lethal doses of the antibiotic-resistant strain of Ps. aeruginosa. Correlation between the effectiveness of the drug and the dose and time of its administration was found. Pronounced prophylactic and therapeutic effect of gentamicin in combination with decamethoxin was noted. Prodigiozan, a bacterial polysaccharide had no significant effect on the experimental pyocyanic infection of albino mice.
D000818:Animals; D003650:Decamethonium Compounds / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D005839:Gentamicins / Q000627:therapeutic use*; D008070:Lipopolysaccharides / Q000627:therapeutic use*; D051379:Mice; D011135:Polysaccharides, Bacterial / Q000627:therapeutic use*; D011552:Pseudomonas Infections / Q000188:drug therapy*; D018805:Sepsis / Q000188:drug therapy*; D012706:Serratia marcescens
D003650:Decamethonium Compounds; D005839:Gentamicins; D008070:Lipopolysaccharides; D011135:Polysaccharides, Bacterial; C000858:decamethoxine
Vliianie gentamitsina, dekametoksina i prodigiozana na techenie i iskhod éksperimental'noĭ sinegnoĭnoĭ infektsii belykh mysheĭ.