[Restoration of antineoplastic reactivity of the leukocytes after preincubation].
Specific antitumor sensitization in patients with carcinoma of the stomach was revealed by means of the leukocyte migration inhibition test. After 24-hour preincubation at 4 degrees C in a serum-free medium the areactive leukocytes from patients with carcinoma of the stomach (stages III--IV) acquired the ability to react specifically to allogeneic antigens of the tumor of the same localization. Preincubation did not influence the inhibition of migration of leukocytes in non-tumor patients by stomach carcinoma antigens. The supernatant of preincubated leukocytes of tumor patients contained substances that inhibited migration of indicator leukocytes.
D000328:Adult; D000368:Aged; D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology*; D002417:Cattle; D002464:Cell Migration Inhibition; D002478:Cells, Cultured; D003470:Culture Media; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007961:Leukocyte Migration-Inhibitory Factors / Q000276:immunology*; D007962:Leukocytes / Q000276:immunology*; D008222:Lymphokines / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D013274:Stomach Neoplasms / Q000276:immunology*
D000951:Antigens, Neoplasm; D003470:Culture Media; D007961:Leukocyte Migration-Inhibitory Factors; D008222:Lymphokines
Vosstanovlenie protivoopukholevoĭ reaktivnosti leíkotsitov bol'nykh rakom posle preinkubatsii.