[Alternative complement pathway (author's transl)].
The dual role of the alternative complement pathway in recognition of foreign substances by a non-immune host and in the intrinsic regulation of the complement sequence is now well recognized. Activation of this pathway occurs through escape from its regulatory mechanisms induced by the activating principle; its functional expression depends on the respective levels of the component proteins C3, factor B, factor D and properdin, and on the control proteins beta 1H and C3bINA. This article presents recently acquired knowlege on the molecular mechanisms of activation, regulation and behaviour under pathological conditions of the alternative complement pathway.
D003167:Complement Activation; D003176:Complement C3 / Q000032:analysis / Q000235:genetics; D050577:Complement C3-C5 Convertases / Q000378:metabolism; D003180:Complement C3b Inactivator Proteins / Q000032:analysis; D011415:Complement Factor B / Q000032:analysis; D011416:Complement Factor D / Q000032:analysis; D003170:Complement Pathway, Alternative; D003165:Complement System Proteins / Q000378:metabolism; D006801:Humans; D011414:Properdin / Q000032:analysis
D003176:Complement C3; D003180:Complement C3b Inactivator Proteins; D011414:Properdin; D003165:Complement System Proteins; D050577:Complement C3-C5 Convertases; C493488:CFD protein, human; D011416:Complement Factor D; D011415:Complement Factor B
La voie alterne du complément.