A single dose comparison of piretanide and bumetanide in congestive cardiac failure.
1 This study has compared the diuresis produced by a single oral administration of 6 mg piretanide, 9 mg piretanide and 1 mg bumetanide in a group of nine patients with cardiac failure using a balanced randomized design. 2 The natriuresis and kaliuresis produced in the first 6 h after administration of piretanide 9 mg and bumetanide 1 mg were similar. Piretanide 6 mg produced a lesser response. 3 There was evidence of sodium and water conservation following the diuresis for up to 48 h with all three treatments. 4 The patterns of urate and calcium excretion were similar for the two diuretics.
D000368:Aged; D002034:Bumetanide / Q000009:adverse effects / Q000627:therapeutic use*; D002118:Calcium / Q000652:urine; D002986:Clinical Trials as Topic; D004232:Diuretics / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006333:Heart Failure / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D013449:Sulfonamides / Q000009:adverse effects / Q000627:therapeutic use*; D013997:Time Factors; D014527:Uric Acid / Q000652:urine
D004232:Diuretics; D013449:Sulfonamides; D002034:Bumetanide; D014527:Uric Acid; C015451:piretanide; D002118:Calcium