[Effectiveness of oral immunization of white mice with a complex S. typhimurium antigen].
The protective properties of hydroxylamine preparation obtained from a virulent strain of S. typhimurium were studied in experiments with natural infection after a single oral immunization. The new data obtained in these experiments suggest that the treatment of bacteria with hydroxylamine allows to produce the preparation which, when administered orally, has the immunizing dose only 20 times as great as its immunizing dose for subcutaneous administration. The action of gastric juice on hydroxylamine preparation, as well as the duration and specificity of immunity induced by the oral administration of this preparation were studied. The oral administration of some adjuvants was found to make it possible to considerably decrease the effective dose of the vaccine.
D000818:Animals; D000942:Antigens, Bacterial / Q000008:administration & dosage*; D001428:Bacterial Vaccines / Q000008:administration & dosage; D004306:Dose-Response Relationship, Immunologic; D005750:Gastric Juice / Q000378:metabolism; D006898:Hydroxylamines / Q000494:pharmacology; D007279:Injections, Subcutaneous; D007928:Lethal Dose 50; D051379:Mice; D012481:Salmonella Infections, Animal / Q000517:prevention & control*; D012477:Salmonella enteritidis / Q000276:immunology; D012486:Salmonella typhimurium / Q000187:drug effects / Q000276:immunology*
D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; D006898:Hydroxylamines
Effektivnost' peroral'noĭ immunizatsii belykh mysheĭ kompleksnym antigenom S. typhimurium.