title: Indocyanine green clearance in critically ill patients.
abstract: Forty-two consecutive patients were observed with the use of various biochemical and physiologic parameters. Attention was focused upon liver function, using serum glutamic-oxalacetic transaminase, alkaline phosphatase and bilirubin determinations as well as the plasma disappearance rate of indocyanine green. No difference was noted in serum glutamic-oxalacetic transaminase, alkaline phosphatase and bilirubin levels between survivors and nonsurvivors. However, there was a significant difference between these two groups as measured by the plasma disappearance rate of indocyanine green. A distinct cut-off point was present, and no survivor ever had a plasma disappearance rate of less than 6 per cent per minute.
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D001711:Biotransformation; D003422:Critical Care; D004395:Dye Dilution Technique; D006801:Humans; D007208:Indocyanine Green / Q000378:metabolism; D008099:Liver / Q000503:physiopathology*; D008111:Liver Function Tests / Q000379:methods*; D008657:Metabolic Clearance Rate; D013514:Surgical Procedures, Operative
chemical_list: D001219:Aspartate Aminotransferases; D000469:Alkaline Phosphatase; D007208:Indocyanine Green; D001663:Bilirubin