title: History of occlusive cerebrovascular disease I. from Wepfer to Moniz.
abstract: Occlusive cerebrovascular disease of carotid and vertebral arteries was described by Wepfer in 1658 and by Willis in 1665. Wepfer thought apoplexy resulted from occlusive disease of the vessels. Willis described collateral channels between these vessels, which prevented the development of stroke.
mesh_terms: D000818:Animals; D002340:Carotid Artery Diseases / Q000266:history; D002561:Cerebrovascular Disorders / Q000266:history*; D049670:History, 17th Century; D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans; D014711:Vertebral Artery