Immunosuppressive activity of ledakrin.
The influence of the cytostatic drug Ledakrin on immunologic induction of PF and RF cells was studied. In low doses, the drug had a negligibly small effect on the numbers of PFC and RFC, but in high doses nearly entirely prevented their appearance. Cells producing IgM were more susceptible to this action than IgG-producing cells. Absence of a linear relation between the dose of the drug and its action was noteworthy. Drug-induced immunosuppression occured in "all-or-none" fashion. The possibility of oncostatic effect without interfering with the immunologic system is discussed.
D000166:Acridines / Q000494:pharmacology*; D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006462:Hemolytic Plaque Technique; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D007166:Immunosuppressive Agents; D051379:Mice; D008815:Mice, Inbred Strains; D009564:Nitracrine / Q000494:pharmacology*; D012397:Rosette Formation
D000166:Acridines; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007166:Immunosuppressive Agents; D009564:Nitracrine