Practical aspects of selection of streptomyces mutants.
The methods of industrial strains selection on the basis of some regulatory mechanisms are presented. The selection of the producing S. erythreus mutants exhibiting higher activity for transformation of erythromycin C to erythromycin A is one of the examples for the practical use of the presented method. Some new techniques including isotopic methods are presented.
D001431:Bacteriological Techniques; D003470:Culture Media; D004917:Erythromycin / Q000096:biosynthesis*; D008034:Lincomycin / Q000096:biosynthesis*; D009154:Mutation; D011422:Propionates / Q000494:pharmacology; D013302:Streptomyces / Q000235:genetics* / Q000378:metabolism
D003470:Culture Media; D011422:Propionates; D004917:Erythromycin; D008034:Lincomycin