Capping of exogenous Forssman glycolipid on cells.
When motile cells are incubated with Forssman glycolipid, the antigen is incorporated into the cells' plasma membranes. If cross-linked by antibody, the patched glycolipids cap. This process is sensitive to those drugs that are known to inhibit capping of protein antigens. The results support a flow mechanism for capping.
D000818:Animals; D002460:Cell Line; D002462:Cell Membrane / Q000276:immunology; D003078:Colchicine / Q000494:pharmacology; D003571:Cytochalasin B / Q000494:pharmacology; D004140:Dinitrophenols / Q000494:pharmacology; D005455:Fluorescent Antibody Technique; D005577:Forssman Antigen / Q000276:immunology*; D006017:Glycolipids / Q000276:immunology*; D007152:Immunologic Capping / Q000187:drug effects; D051379:Mice; D009369:Neoplasms; D013601:T-Lymphocytes / Q000276:immunology*
D004140:Dinitrophenols; D006017:Glycolipids; D003571:Cytochalasin B; D005577:Forssman Antigen; D003078:Colchicine