title: [Immunological reactions in the secretions of volunteers vaccinated against influenza by aerosol and intranasally].
abstract: Aerosol and intranasal methods of influenza vaccination were studied on volunteers. Aerosol vaccination induced intensive S-IgA-producing reaction and increase of the specific antibody titres in the saliva and nasal secretions. Intranasal vaccination led to increase of influenza antibodies in the washings from the nasopharynx. The presence of a wide spectrum of antiviral and antibacterial normal secretory antibodies was revealed in the fluids under study. Along with stimulation of specific secretory antibodies, the methods of influenza vaccination under study led to increase of the titre of antibodies nonspecific of the vaccine used.
mesh_terms: D000293:Adolescent; D000328:Adult; D000336:Aerosols; D000907:Antibodies, Bacterial / Q000032:analysis; D000914:Antibodies, Viral / Q000032:analysis; D000918:Antibody Specificity; D000937:Antigen-Antibody Reactions; D002986:Clinical Trials as Topic; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000032:analysis; D007252:Influenza Vaccines / Q000008:administration & dosage; D007251:Influenza, Human / Q000517:prevention & control*; D008297:Male; D009093:Mucus / Q000276:immunology*; D009297:Nasal Mucosa / Q000378:metabolism; D010919:Placebos; D012463:Saliva / Q000276:immunology*; D014611:Vaccination / Q000379:methods*
chemical_list: D000336:Aerosols; D000907:Antibodies, Bacterial; D000914:Antibodies, Viral; D007071:Immunoglobulin A, Secretory; D007252:Influenza Vaccines; D010919:Placebos
vernacular_title: Immunologicheskie reaktsii v sekretakh u dobrovol'tsev pri aérozol'noĭ i intranazal'noĭ vaktsinatsii protiv grippa.