Cardiovascular tolerance of mianserin and interactions of mianserin with other drugs.
The presented data clearly show that mianserin, which is therapeutically equal to other antidepressants, is a drug with a new chemical structure, with a most probably different mechanism of action and with distinct advantages above comparative drugs. Mianserin has not only pronouncedly fewer anticholinergic and central side-effects but: a) apparently has no cardiotoxic effects neither on healthy subjects nor on depressive individuals nor on cardiac patients; b) doses not cause orthostatic hypotension; c) is devoid of adverse drug-drug interactions with coumarin-like anticoagulants, with sympathomimetic amines, with antihypertensive agents and shows but little and short lasting interactions with alcohol.
D000925:Anticoagulants / Q000494:pharmacology; D000959:Antihypertensive Agents / Q000494:pharmacology; D001777:Blood Coagulation / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects*; D002986:Clinical Trials as Topic; D003984:Dibenzazepines / Q000494:pharmacology*; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology; D006321:Heart / Q000187:drug effects; D006801:Humans; D008803:Mianserin / Q000494:pharmacology*; D013566:Sympathomimetics / Q000494:pharmacology
D000925:Anticoagulants; D000959:Antihypertensive Agents; D003984:Dibenzazepines; D013566:Sympathomimetics; D008803:Mianserin; D000431:Ethanol