title: Effects of fluorostigmine, toxogonin and atropine on monoamine oxidase activity and the level of biogenic amines in mouse brain.
abstract: Effects of fluorostigmine, toxogonin and atropine on monoamine oxidase activity and the level of biogenic amines in mouse brain. Acta physiol. pol., 1979, 30 (4): 437--444. Fluorostigmine (DFP) given i.p. to mice in doses of 1.2 and 2.45 mg/kg reduced MAO activity in the brain. Given in doses of 0.6 and 1.2 mg/kg it reduced the level of noradrenaline and dopamine as well as 5-hydroxytryptamine in the brain. DFP in such doses had no effect on the brain level of 5-hydroxyindoloacetic acid. Toxogonin (5 mg/kg i.p.) or atropine (5 mg/kg i.p.) given together with DFP reduced or abolished completely the inhibitory effect of DFP.
mesh_terms: D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D001679:Biogenic Amines / Q000032:analysis*; D001921:Brain / Q000201:enzymology*; D001923:Brain Chemistry; D004347:Drug Interactions; D007531:Isoflurophate / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008995:Monoamine Oxidase / Q000378:metabolism*; D009768:Obidoxime Chloride / Q000494:pharmacology*; D010091:Oximes / Q000494:pharmacology*
chemical_list: D001679:Biogenic Amines; D010091:Oximes; D007531:Isoflurophate; D009768:Obidoxime Chloride; D001285:Atropine; D008995:Monoamine Oxidase