A comparative clinical trial of diflunisal and ibuprofen in the control of pain in osteoarthritis.
A randomized double-blind study in ambulatory patients with osteoarthritis of hip and/or knee was conducted, comparing the efficacy and safety of diflunisal 500 mg daily with ibuprofen 1200 mg daily, and a period of 8 weeks. Thirty-five patients participated in the study. The results revealed no significant differences between the treatment groups with regard to the efficacy parameters.
D002986:Clinical Trials as Topic; D004061:Diflunisal / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006621:Hip Joint; D006801:Humans; D007052:Ibuprofen / Q000627:therapeutic use*; D007719:Knee Joint; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000150:complications*; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D012459:Salicylates / Q000627:therapeutic use*
D012459:Salicylates; D004061:Diflunisal; D007052:Ibuprofen