[Clinical significance of immunological findings for the survival time of kidney transplants with antilymphocyte globulin therapy].
A balanced combination of immunosuppressive regimens like cortisone, azathioprine and ALG can not only reduce the frequency, but also the severity of rejection episodes in kidney transplant patients. Addition of ALG influences the lymphocyte populations, especially T-lymphocytes. The significant reduction produced obviously includes cytotoxic effector lymphocytes as well as socalled regulator cells (suppressor cells). It seems as if this beneficial function for the graft is not only reduced under immunosuppressive therapy and administration of ALG, but disappears during rejection crises. The results indicate, however, that these cell populations recover quickly after finishing the immunosuppressive regimen.
D000961:Antilymphocyte Serum / Q000627:therapeutic use*; D001379:Azathioprine / Q000627:therapeutic use; D005455:Fluorescent Antibody Technique; D006084:Graft Rejection / Q000187:drug effects*; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000032:analysis; D016030:Kidney Transplantation; D008213:Lymphocyte Activation; D011239:Prednisolone / Q000627:therapeutic use; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D014184:Transplantation, Homologous
D000961:Antilymphocyte Serum; D007140:Immunoglobulin Fab Fragments; D011239:Prednisolone; D001379:Azathioprine
Klinische Bedeutung immunologischer Befunde für die Uberlebenszeit von Nierentransplantaten unter ALG-Therapie.