title: Humoral and cell-mediated immune response to crude antigens of Dermatophilus congolensis during experimental infection of rabbits.
abstract: Rabbits were infected with Dermatophilus congolensis and tested for humoral immune response by indirect haemagglutination and for cell-mediated immune response to crude antigens of D. congolensis. Lymphocyte transformation and macrophage migration inhibition assays were used as in vitro correlates of cell-mediated immune response while cutaneous delayed hypersensitivity was used in vivo. Endo-antigen and whole cell antigen were found to significantly induce cell-mediated immune response. In contrast, humoral responses were found to be more significantly induced by exo-antigen. A biphasic immune response was revealed by the lymphocyte transformation test.
mesh_terms: D000192:Actinomycetales / Q000276:immunology*; D000193:Actinomycetales Infections / Q000276:immunology*; D000818:Animals; D000907:Antibodies, Bacterial / Q000302:isolation & purification*; D000917:Antibody Formation; D006386:Hemagglutination Tests; D007109:Immunity; D007111:Immunity, Cellular; D008213:Lymphocyte Activation; D008263:Macrophage Migration-Inhibitory Factors; D011817:Rabbits; D012882:Skin Tests
chemical_list: D000907:Antibodies, Bacterial; D008263:Macrophage Migration-Inhibitory Factors