title: The clinical effect of ketotifen in bronchial asthma.
abstract: A therapeutical trial using ketotifen, a prophylactic agent for the long-term treatment of bronchial asthma, was undertaken. Twenty-nine patients with a mean age of 33 years and suffering from bronchial asthma for six months to 20 years (mean 8.6 years) were treated for three months. Ketotifen demonstrated good results in alleviating the impact of the disease on the asthmatic patient. The lowering of the frequency of asthmatic attacks, their duration and the degree of dyspnoea was accompanied by a normalization of lung function parameters. An analysis of further respiratory investigations showed that the best results are to be obtained in the uncomplicated asthmatic. The need for the prophylactic treatment of asthma with an agent such as ketotifen is stressed, as only in this way can irreversible changes be prevented.
mesh_terms: D000328:Adult; D001249:Asthma / Q000188:drug therapy* / Q000453:epidemiology / Q000517:prevention & control; D002245:Carbon Dioxide / Q000097:blood; D002986:Clinical Trials as Topic; D004417:Dyspnea / Q000209:etiology; D005260:Female; D006801:Humans; D008168:Lung / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010880:Piperidines / Q000627:therapeutic use*; D012129:Respiratory Function Tests; D013147:Spirometry; D013876:Thiophenes / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D010880:Piperidines; D013876:Thiophenes; D002245:Carbon Dioxide; D010100:Oxygen