[Action of a polypeptide epiphyseal extract on cervical cancer].
The authors report the results of experimental and clinical estimation of the effect of polypeptide extract of the epiphysis (epithalamin) on cervical cancer. Injection of epithalamin is shown to improve the cell immunity indices and renders an antitumor action. The experiments on mice with the transplantable squamous cell cancer of the cervix (strain SCC) have indicated a marked antitumor effect of epithalamin and its potentiating effect on cyclophosphan action.
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D002417:Cattle; D002986:Clinical Trials as Topic; D003520:Cyclophosphamide / Q000627:therapeutic use; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D004838:Epiphyses; D005260:Female; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy; D010455:Peptides / Q000276:immunology / Q000627:therapeutic use*; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy*
D010455:Peptides; D003520:Cyclophosphamide
Deĭstvie polipeptidnogo ékstrakta épifiza na rak sheĭki matki.