Somatostatin in the pancreas and hypothalamus of obese mice.
The pancreatic content of somatostatin, insulin, and glucagon and the hypothalamic content of somatostatin were examined in ob/ob mice at various ages and in goldthioglucose-obese mice. The total pancreatic content of somatostatin was increased in ob/ob mice compared to controls: 92 ng vs 75 ng (a 22% increase) at 2 months of age; 208 ng vs 131 ng (a 60% increase) at 6 months of age; and 184 ng vs 118 ng (a 60% increase) at 8 months of age. The total pancreatic content of glucagon in ob/ob mice was already enhanced by 70% over controls at 2 months of age (301 ng vs 173 ng) and did not increase further at later stages, whereas that of insulin progressively rose with age. In goldthioglucose-obese mice the pancreatic content of insulin was also increased but to a lesser extent than in ob/ob mice; the pancreatic levels of somatostatin and glucagon were unaltered. In both ob/ob mice (regardless of age) and goldthioglucose-obese mice, there was no significant change in the hypothalamic content of somatostatin compared with that of lean controls.
D000375:Aging; D000818:Animals; D006051:Aurothioglucose; D001786:Blood Glucose / Q000032:analysis; D005934:Glucagon / Q000032:analysis; D007031:Hypothalamus / Q000032:analysis* / Q000254:growth & development; D007328:Insulin / Q000032:analysis / Q000097:blood; D051379:Mice; D008820:Mice, Obese; D009929:Organ Size; D010179:Pancreas / Q000032:analysis* / Q000254:growth & development; D013004:Somatostatin / Q000032:analysis*; D013045:Species Specificity
D001786:Blood Glucose; D007328:Insulin; D006051:Aurothioglucose; D013004:Somatostatin; D005934:Glucagon