Mutagenicity of 5,6-dimethoxysterigmatocystin, a metabolite from Aspergillus multicolor, in the Salmonella/microsome system.
The natural sterigmatocystin derivative, 5,6-dimethoxysterigmatocystin, was found to be a mutagen for Salmonella typhimurium strains TA98 and TA100 after metabolic activation in a mammalian microsome system.
D000818:Animals; D001230:Aspergillus / Q000378:metabolism*; D001711:Biotransformation; D055598:Chemical Phenomena; D002621:Chemistry; D008862:Microsomes, Liver / Q000378:metabolism; D009153:Mutagens / Q000096:biosynthesis; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects*; D013241:Sterigmatocystin / Q000031:analogs & derivatives / Q000096:biosynthesis / Q000494:pharmacology*; D014966:Xanthenes / Q000494:pharmacology*
D009153:Mutagens; D014966:Xanthenes; D013241:Sterigmatocystin