Medical treatment of duodenal ulcer.
Recent controlled clinical trials have shown that acute episodes of duodenal ulcer can be treated successfully with either anti-secretory (cimetidine), mucosa-protective (carbenoxolone, organic bismuth preparation) or antacid drugs. For prevention of recurrence, only cimetidine has thus far proved effective. A critical review is presented of the advantages and disadvantages of these drugs in conservative ulcer therapy.
D000863:Antacids / Q000009:adverse effects / Q000627:therapeutic use; D001729:Bismuth / Q000009:adverse effects / Q000627:therapeutic use; D002229:Carbenoxolone / Q000009:adverse effects / Q000627:therapeutic use; D002927:Cimetidine / Q000009:adverse effects / Q000627:therapeutic use; D002951:Citrates / Q000009:adverse effects / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D004381:Duodenal Ulcer / Q000188:drug therapy*; D006801:Humans; D010919:Placebos; D012008:Recurrence; D013997:Time Factors
D000863:Antacids; D002951:Citrates; D010919:Placebos; D002927:Cimetidine; D002229:Carbenoxolone; D001729:Bismuth