Selective reduction of adrenal medulla response to angiotensin induced by suppression of renin-angiotensin.
Angiotensin II (AII) induced an increase of adrenaline (A) release from rat adrenal glands in vitro. The response of the adrenal glands was completely abolished 22--24 h after bilateral nephrectomy. Adrenal glands from DOCA-salt-treated rats did not respond to AII as well, whereas adrenal glands from rats treated with furosemide and a low salt diet retained this response. High potassium in the medium increased significantly the release of A from in vitro incubated adrenal glands of nephrectomized rats from 0.43 +/- 0.04 to 0.63 +/- 0.06 microgram/gland and salbutamol (in calcium-free medium) increased the release from 0.34 +/- 0.03 to 0.43 +/- 0.03 microgram/gland. These results indicate that the adrenal medulla develops subsensitivity to AII in vitro, following a reduction in levels of this agonist in vivo.
D000313:Adrenal Medulla / Q000187:drug effects*; D000804:Angiotensin II / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D057911:Angiotensin Receptor Antagonists; D000818:Animals; D002395:Catecholamines / Q000378:metabolism; D003900:Desoxycorticosterone / Q000494:pharmacology; D005665:Furosemide / Q000494:pharmacology; D008297:Male; D009392:Nephrectomy; D051381:Rats; D011945:Receptors, Angiotensin / Q000187:drug effects; D000092502:Renin Inhibitors
D000804:Angiotensin II; D057911:Angiotensin Receptor Antagonists; D002395:Catecholamines; D003900:Desoxycorticosterone; D005665:Furosemide; D011945:Receptors, Angiotensin; D000092502:Renin Inhibitors