In vitro proliferation of hematopoietic stem cells circulating in blood of patients with kidney allografts.
The in vitro formation of lymphoid (L-CFU) and myeloid (GM-CFU) colonies derived from progenitor cells circulating in blood of patients bearing kidney allografts was studied upon a stimulation with PHA and Colony Stimulating Factor. In patients undergoing acute rejection a marked reduction of L-CFU and GM-CFU was found. Chronic rejection was associated with moderate impairment of GM-CFU proliferation, while patients with stable graft function had moderately reduced L-CFU progenitors with normal level of GM-CFU cells.
D000208:Acute Disease; D002455:Cell Division; D002908:Chronic Disease; D003114:Colony-Forming Units Assay; D006084:Graft Rejection; D006098:Granulocytes / Q000166:cytology; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D016030:Kidney Transplantation; D008214:Lymphocytes / Q000166:cytology; D014184:Transplantation, Homologous