Oral hypoglycemic drugs and cardiovascular pathology.
The classification, the mechanisms of action and the main side effects of sulfonylureic derivatives and biguanides are discussed. Emphasis is laid on the present controversy concerning the assumed adverse effect of these drugs on the cardiovascular system. The authors' opinion in this problem and their practical conclusions are based on their experience at the Center of Nutrition and Metabolic Diseases, Bucharest.
D000328:Adult; D000368:Aged; D001645:Biguanides / Q000009:adverse effects*; D002319:Cardiovascular System / Q000187:drug effects*; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000401:mortality; D003927:Diet, Diabetic; D006321:Heart / Q000187:drug effects; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects* / Q000145:classification; D007328:Insulin / Q000627:therapeutic use; D008875:Middle Aged; D013453:Sulfonylurea Compounds / Q000009:adverse effects*; D014044:Tolbutamide / Q000009:adverse effects*
D001645:Biguanides; D007004:Hypoglycemic Agents; D007328:Insulin; D013453:Sulfonylurea Compounds; D014044:Tolbutamide