title: Further studies on the effects of dihydrotestosterone on gonadotrophin release induced by LH-RH in men.
abstract: In order to determine the effect of dihydrotestosterone on the feed-back mechanism of the hypothalamo-pituitary testis axis, seven men were subjected to LH-RH tests before and after treatment with dihydrotestosterone. Our results clearly show that DHT at least in pharmacological doses, inhibits directly basal LH-RH and gonadotrophin secretion, without affecting the pulsatile gonadotrophin release or impairing the pituitary response to LH-RH. The physiological significance of these observations remains however to be proven.
mesh_terms: D000328:Adult; D013196:Dihydrotestosterone / Q000494:pharmacology*; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology*; D006065:Gonadotropins, Pituitary / Q000378:metabolism*; D006801:Humans; D007031:Hypothalamus / Q000187:drug effects; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism; D013737:Testis / Q000187:drug effects; D013739:Testosterone / Q000097:blood
chemical_list: D006065:Gonadotropins, Pituitary; D013196:Dihydrotestosterone; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone