[Immunsuppression by vitamin B6-antagonists. Prolonged survival of inbred rats with renal transplants (author's transl)].
The combined effect of Vitamin B6 free diet and 4-Desoxipyridoxin (a potent Vitamin B6-Antagonist) on the rejection reaction of inbred rats after renal transplantation was investigated. More than 90% of the control animals without Vitamin B6-deficiency died between 7 and 13 days with uremia due to an acute transplant rejection, where as the Vitamin deficient and successfully transplanted animals (n=38) showed a significantly prolonged survival time. In 17/38 rats survival was longer than 35 days. Vitamin B6-deficiency, induced by Desoxipyridoxin and Vitamin B6-deficient diet offers the possibility of an effective and reversible immunosuppression in renal transplantation.
D000818:Animals; D001835:Body Weight; D007109:Immunity; D007111:Immunity, Cellular; D007165:Immunosuppression Therapy; D007668:Kidney / Q000378:metabolism / Q000473:pathology; D016030:Kidney Transplantation; D009994:Osmolar Concentration; D011507:Proteinuria / Q000209:etiology; D011736:Pyridoxine / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors*; D051381:Rats; D011917:Rats, Inbred Lew; D014184:Transplantation, Homologous; D014556:Urine; D026681:Vitamin B 6 Deficiency
D011736:Pyridoxine
Immunsuppression durch Vitamin B6-Antagonisten. Verlängerte Uberlebenszeit von Inzuchtratten mit Nierentransplantaten.