title: Immunogenicity of fresh and preserved cortical and cancellous allogeneic bone grafts as tested by modified migration inhibition test in mice.
abstract: Mice were grafted with allogeneic compact and cancellous bone. The bone used was fresh and preserved by either lyophilization or deep freezing. Preserved grafts were radiosterilized by a dose of 3.3 MRads. The immunization of recipients was assessed by a modified migration inhibition test based on migration of cells from three-dimensional clot culture. Both preservation methods seem to change bone immunogenicity and enhancement of migration instead of inhibition occurring in the case of fresh bone was noted.
mesh_terms: D000818:Animals; D016025:Bone Transplantation; D001842:Bone and Bones / Q000276:immunology*; D002464:Cell Migration Inhibition; D005260:Female; D007111:Immunity, Cellular; D051379:Mice; D011309:Preservation, Biological; D014184:Transplantation, Homologous