Endothelial antibodies in renal transplantation.
Sera of 97 consecutive transplant recipients were studied for the presence of antibodies directed against their renal allografts. A highly significant correlation (p less than 0.001) was found between irreversible rejection and donor-specific endothelial antibodies (EAb). EAb reacted not only with the endothelium of peritubular capillaries and venules, but also with glomeruli. Absorption of EAb to platelets, B- or T-lymphocytes did not remove its EAb activity or its cytotoxicity for monocytes. Furthermore, it was shown with a panel of randomly chosen donor kidneys, that EAb are directed against a polymorphic system of endothelial-monocyte antigens, which is unrelated to HLA-A, -B, -C or -D.
D000906:Antibodies; D001666:Binding Sites, Antibody; D004727:Endothelium / Q000276:immunology; D006084:Graft Rejection; D006801:Humans; D007074:Immunoglobulin G; D007518:Isoantibodies; D007668:Kidney / Q000276:immunology; D007678:Kidney Glomerulus / Q000276:immunology; D016030:Kidney Transplantation; D009000:Monocytes / Q000276:immunology; D011110:Polymorphism, Genetic; D014184:Transplantation, Homologous
D000906:Antibodies; D007074:Immunoglobulin G; D007518:Isoantibodies