title: [Piracetam and vigilance. A study of EEG changes and clinical effects in gerontopsychiatric patients (author's transl)].
abstract: The electroencephalographic and clinical effects of piracetam were studied in a group of 11 hospitalized gerontopsychiatric patients treated with a daily dosage of 4.8 g for 8--13 months. The EEG was evaluated by power spectral analysis, followed by a principal component analysis of frequency parameters. The statistical analysis of the resulting factor scores shows that piracetam induces significant EEG changes: decrease of slow frequencies, augmentation and acceleration of alpha-activity and increase of beta-activity. These EEG changes, indicating an increase in vigilance, correspond clinically to an improvement of communicative behavior and cognitive functioning.
mesh_terms: D000368:Aged; D001143:Arousal / Q000187:drug effects*; D002986:Clinical Trials as Topic; D003071:Cognition / Q000187:drug effects; D003142:Communication; D004569:Electroencephalography; D006801:Humans; D008875:Middle Aged; D010889:Piracetam / Q000494:pharmacology* / Q000627:therapeutic use; D010919:Placebos; D011760:Pyrrolidinones / Q000494:pharmacology*; D012919:Social Behavior
chemical_list: D010919:Placebos; D011760:Pyrrolidinones; D010889:Piracetam
vernacular_title: Piracetam und Vigilanz. Elektroenzephalographische und klinische Ergebnisse einer Langzeitmedikation bei gerontopsychiatrischen Patienten.