title: Growth control by cell to cell contact.
abstract: Control of cell growth by cell to cell contact is reviewed with particular emphasis on two systems--contact inhibition of growth observed with Swiss 3T3 cells and the mitogenic stimulation of Schwann cells by dorsal root ganglia neurites. In both cases the biological effect can be reproduced by the addition of surface membranes to the corresponding cells. In the case of contact inhibition of 3T3 cells, biological activity appears to correlate with membrane binding to the cells. An octylglucoside extract of 3T3 plasma membranes retains the biological activity (growth inhibition) of the original membranes.
mesh_terms: D000621:Aminoisobutyric Acids / Q000378:metabolism; D000818:Animals; D002450:Cell Communication; D002453:Cell Cycle; D002462:Cell Membrane / Q000032:analysis / Q000502:physiology; D004815:Epidermal Growth Factor; D005727:Ganglia, Spinal / Q000196:embryology; D006128:Growth; D006131:Growth Inhibitors / Q000032:analysis; D051379:Mice; D008934:Mitogens / Q000032:analysis; D011975:Receptors, Mitogen / Q000502:physiology; D012583:Schwann Cells / Q000502:physiology; D014529:Uridine / Q000378:metabolism
chemical_list: D000621:Aminoisobutyric Acids; D006131:Growth Inhibitors; D008934:Mitogens; D011975:Receptors, Mitogen; D004815:Epidermal Growth Factor; D014529:Uridine