Mutagenic cholesterol preparations.
Naturally air-aged commercial samples of USP or reagent-grade cholesterol contain components which are mutagenic towards Salmonella typhimurium strains TA1537, TA1538 and TA98. These mutagenic components are associated with the polar cholesterol autoxidation products, but identity of the mutagenic components has not been achieved. Pure crystalline nonmutagenic cholestrol free from autoxidation products becomes mutagenic towards these strains upon heating at 70 degrees in air or following exposure to 60 Co gamma-radiation.
D002784:Cholesterol / Q000378:metabolism / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D005821:Genetic Techniques; D009153:Mutagens; D010084:Oxidation-Reduction; D012486:Salmonella typhimurium / Q000235:genetics
D009153:Mutagens; D002784:Cholesterol