Somatostatin content and release of isolated pancreatic islets from obese-hyperglycemic mice.
The somatostatin content in pancreatic islets of obese-hyperglycemic mice was much lower than in the islets of normal mice. Also the release of somatostatin was decreased from the islets obtained from the obese-hyperglycemic mice. Tissue culture for 1 week changed neither the content of, nor the amount of somatostatin released from, the pancreatic islets.
D000818:Animals; D002478:Cells, Cultured; D006943:Hyperglycemia / Q000378:metabolism*; D007515:Islets of Langerhans / Q000378:metabolism*; D051379:Mice; D008820:Mice, Obese / Q000378:metabolism*; D013004:Somatostatin / Q000378:metabolism*
D013004:Somatostatin