title: [Metabolic pathways of exogenous pyrimidines in Aspergillus nidulans].
abstract: Studies on the susceptibility of the wild-type strain of Aspergillus nidulans to 6-azauracil suggest that it synthesizes pyrimidines using a by-pass pathway which is induced with 6-azauracil. The effect of a series of pyrimidines on the toxic action of 5-fluorouracil, 5-fluorouidine and 5-fluorodeoxyuridine has been investigated. As the result of these studies, a scheme is proposed for the metabolism of some pyrimidine bases and nucleosides in Aso. nidulans.
mesh_terms: D001233:Aspergillus nidulans / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D011743:Pyrimidines / Q000378:metabolism* / Q000633:toxicity; D013997:Time Factors
chemical_list: D011743:Pyrimidines
vernacular_title: Puti metabolizma ékzogennykh pirimidinov u Aspergillus nidulans.