Mutagenicity of cyclic nitrosamines in Salmonella typhimurium: effect of ring size.
Mutagenicity of cyclic nitrosamines with varying carcinogenic potentials was assayed in the Salmonella histidine-reversion system. Mutagenicity in the pour-plate assay was compared with that in the liquid pre-incubation test. The smaller ring compounds (nitrosoazetidine, nitrosopyrrolidine, and nitrosopiperidine) exhibited a similar effect in both assays. The large ring compounds (nitrosohexamethyleneimine, nitrosoheptamethyleneimine, nitrosooctamethyleneimine, and nitrosododecamethyleneimine) were more effective in the liquid pre-incubation test. Our results suggest a reasonable relationship between their mutagenic and carcinogenic activities.
D004353:Drug Evaluation, Preclinical; D005821:Genetic Techniques; D008968:Molecular Conformation; D009153:Mutagens; D009602:Nitrosamines / Q000032:analysis / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000235:genetics
D009153:Mutagens; D009602:Nitrosamines