Synthesis and antibacterial activity of 2'-substituted chelocardin analogues.
Chelocardin (1) was condensed with numerous hydrazines, hydrazides, and anilines, yielding 2'-substituted derivatives with antibacterial spectra similar to the parent antibiotic. The hydrazone derivatives 9 and 10 and the two anilino derivatives 42 and 44 had more in vivo antibacterial activity than chelocardin.
D000818:Animals; D008722:Methods; D051379:Mice; D008826:Microbial Sensitivity Tests; D011512:Proteus Infections / Q000188:drug therapy; D011513:Proteus mirabilis; D011514:Proteus vulgaris / Q000187:drug effects / Q000254:growth & development; D013754:Tetracyclines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use
D013754:Tetracyclines