Genetic activity of chemicals in yeast: DNA alterations and mutations induced by alkylating anti-cancer agents.
The simple eukaryotic organism baker's yeast allows demonstration of primary DNA lesions in parallel with measurement of mutagenicity and lethality after treatment with alkylating chemicals. Several anti-cancer drugs formed cross-linked DNA molecules and were genetically active. The mutagenicity and lethality of these drugs varied substantially and were dependent on the function of some processes of DNA dark-repair.
D000477:Alkylating Agents / Q000378:metabolism / Q000494:pharmacology*; D004247:DNA / Q000378:metabolism*; D005821:Genetic Techniques; D009153:Mutagens; D012441:Saccharomyces cerevisiae / Q000235:genetics
D000477:Alkylating Agents; D009153:Mutagens; D004247:DNA