title: Injury and repair of liver cells.
abstract: Alterations in hepatocytes, progressing to necrosis, are the morphologic basis for the main clinical manifestations and aberrations in hepatic test results in acute and chronic liver disease. The light-microscopic manifestations of hepatocellular injury, the mechanisms of necrosis, the light-microscopic features of repair and regeneration, and the applications of histologic alterations to the management and prognosis of liver disease are reviewed.
mesh_terms: D001706:Biopsy; D002779:Cholestasis / Q000473:pathology; D003937:Diagnosis, Differential; D006505:Hepatitis / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D008099:Liver / Q000378:metabolism / Q000473:pathology*; D008107:Liver Diseases / Q000473:pathology*; D008115:Liver Regeneration; D009336:Necrosis; D009940:Organoids / Q000473:pathology; D011379:Prognosis