The mutagenicity of natural products from marine algae.
5 polyhalogenated hydrocarbon natural products isolated from the marine red alga Plocamium spp. were tested for mutagenicity in the Ames reversion assay. All 5 of the compounds induced revertants in Salmonella typhimurium strains TA100 and TA1535, indicating the mutational events involved base substitutions. One of the compounds, designated cross-conjugated ketone, was shown to be almost 200 times more effective as a mutagen than was ethyl methanesulfonate.
D006846:Hydrocarbons, Halogenated / Q000302:isolation & purification / Q000494:pharmacology*; D009153:Mutagens; D009154:Mutation / Q000187:drug effects*; D000461:Rhodophyta / Q000032:analysis*; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000235:genetics; D013045:Species Specificity
D006846:Hydrocarbons, Halogenated; D009153:Mutagens