[Therapy of chronic hepatitis (author's transl)].
The favorable effect of glucocorticoids on the development of the chronic active hepatitis is statistically proved on the basis of the amelioration of the survival rate in controlled studies. The so-called lupoid hepatitis is significantly better influenced than the HBs-Ag positive chronic hepatitis. By additional therapy with azathioprine it is possible to reduce the dose of glucocorticoids. Therefore it is better to combine glucocorticoids and azathioprine in some cases, especially in those with a high dosed glucocorticoid therapy. Further prospective studies are necessary to check more precisely the therapeutic effect of the different remedies. The effect of D-penicillamine is vague. A treatment with chloroquine is indicated in cases with contraindications again glucocorticoids and azathioprine.
D001379:Azathioprine / Q000627:therapeutic use; D002738:Chloroquine / Q000627:therapeutic use; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use; D006505:Hepatitis / Q000188:drug therapy* / Q000276:immunology; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006801:Humans; D010396:Penicillamine / Q000627:therapeutic use; D013997:Time Factors
D005938:Glucocorticoids; D006514:Hepatitis B Surface Antigens; D002738:Chloroquine; D010396:Penicillamine; D001379:Azathioprine
Die Therapie der chronischen Hepatitis.