[Renal kallikrein-kinin system and control of blood pressure (author's transl)].
Kallikrein excreted with the urine appears to be formed in the kidney. The kallikrein-kinin system in the kidney is localized in the distal nephron from the juxtaglomerular apparatus to the collecting duct. It has been shown that intrarenal infusion of kinins produces an increase in renal blood flow as well as diuresis and natriuresis. Part of the effect of kinins appears to be mediated by the release of prostaglandins. However, the precise role of the renal kallikrein-kinin system in sodium and volume homeostasis and in blood pressure regulation still remains to be determined. Mineralocorticoids as well as the diuretics furosemide, bumetanide and bendroflumethiazide increase, spironolactone decreases kallikrein excretion. Urinary kallikrein has been shown to increase acid-as well as cryoactivation of prorenin in vitro. It is unclear as yet, however, whether the renal kallikrein-kinin system takes part in converting inactive prorenin into active renin in vivo. There are reports on subnormal, normal as well as increased kallikrein excretion in spontaneously hypertensive rats. In rats susceptible to the hypertensive effect of salt a substantially decreased excretion of kallikrein has been observed. Kallikrein excretion has been described to be increased in primary aldosteronism and to be reduced in a proportion of patients with established essential hypertension. In patients with labile hypertension, however, kallikrein excretion appears to be normal suggesting that decreased urinary kallikrein in essential hypertension is a consequence rather than a cause of hypertension. The renal kallikrein-kinin system does not appear to play a primary role in the pathogenesis of hypertension.
D000804:Angiotensin II / Q000502:physiology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004231:Diuresis / Q000187:drug effects; D004232:Diuretics / Q000494:pharmacology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D007610:Kallikreins / Q000378:metabolism / Q000502:physiology*; D007668:Kidney / Q000378:metabolism / Q000502:physiology*; D007704:Kininogens / Q000378:metabolism; D007705:Kinins / Q000378:metabolism / Q000502:physiology*; D008901:Mineralocorticoids / Q000502:physiology; D009318:Natriuresis / Q000187:drug effects; D011247:Pregnancy; D011453:Prostaglandins / Q000502:physiology; D051381:Rats; D012083:Renin / Q000502:physiology
D004232:Diuretics; D007704:Kininogens; D007705:Kinins; D008901:Mineralocorticoids; D011453:Prostaglandins; D000804:Angiotensin II; D007610:Kallikreins; D012083:Renin
Renales Kallikrein-Kinin-System und Blutdruckregulation.