Single versus divided daily dosages of clomipramine. Plasma concentration and clinical effect.
Sixteen depressed patients have been treated with a daily dose of 150 mg clomipramine for 20 days. Every patient received the total dose at night for 10 days and three times daily for 10 days according to a double-blind, cross-over design. No differences were noted between the two dose regimens, either regarding the clinical effect or the side effects. The plasma level ratio of parent drug to demethylated metabolite was higher on single than multiple doses.
D000293:Adolescent; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D002997:Clomipramine / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D003863:Depression / Q000188:drug therapy*; D003984:Dibenzazepines / Q000008:administration & dosage*; D004311:Double-Blind Method; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011674:Pulse / Q000187:drug effects
D003984:Dibenzazepines; D002997:Clomipramine