title: Emergency treatment of variceal hemorrhage.
abstract: The cirrhotic patient with acute bleeding from esophageal varices has less than a 50% chance of leaving the hospital alive; the outlook for survival is so poor that even desperate measures are worthwhile. Some traditional nonsurgical methods for the control of the bleeding are either ineffective at worst or temporary at best. Balloon tamponade is not recommended at all, but intravenously administered vasopressin may be helpful in allowing the necessary diagnostic investigations to be completed. Most important at this stage are the measures necessary to improve the general status of the patient--restoration of blood volume with fresh blood, prevention of ammonia intoxication, support of the liver, correction of metabolic alkalosis and treatment of the hyperdynamic state with digitalis and cardiotonic drugs. Controlling the bleeding is not the greatest problem--the greatest problem is achieving survival of a critically ill patient who undergoes a formidable operation (e.g., variceal ligation stops the bleeding, but is itself an operation of considerable magnitude). In our hands emergency shunting is the best treatment providing a definitive procedure with the highest 10-year survival rate and the lowest complication rate.
mesh_terms: D004630:Emergencies; D004932:Esophageal and Gastric Varices / Q000175:diagnosis / Q000601:surgery / Q000628:therapy*; D006471:Gastrointestinal Hemorrhage / Q000175:diagnosis / Q000628:therapy; D006489:Hemostatic Techniques; D006801:Humans; D007261:Infusions, Intra-Arterial; D007263:Infusions, Parenteral; D008026:Ligation; D008103:Liver Cirrhosis / Q000150:complications; D008638:Mesenteric Arteries; D008722:Methods; D011167:Portacaval Shunt, Surgical; D014667:Vasopressins / Q000008:administration & dosage
chemical_list: D014667:Vasopressins