Humoral and cellular immunity to intrinsic factor in myasthenia gravis.
Myasthenia gravis (MG) is an autoimmune disease often associated with other autoimmune disorders. A case history of MG with a coexisting atypical megaloblastic anaemia with vitamin B12 deficiency and anti Intrinsic Factor (IF) antibodies, led to a study of humoral and cellular immunity to IF in 81 MG patients. Within this series, 3 other patients had a disturbed humoral and cellular immunity to IF. These 3 patients presented no other features of pernicious anaemia. The possible origins and significance of the anti IF antibodies in MG patients are discussed.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000748:Anemia, Macrocytic / Q000276:immunology*; D000749:Anemia, Megaloblastic / Q000150:complications / Q000276:immunology*; D000906:Antibodies / Q000276:immunology; D000917:Antibody Formation; D002648:Child; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007158:Immunologic Techniques; D007437:Intrinsic Factor / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000150:complications / Q000276:immunology*; D014806:Vitamin B 12 Deficiency / Q000150:complications / Q000276:immunology
D000906:Antibodies; D007437:Intrinsic Factor