The use of metronidazole in the preparation of the bowel for surgery.
A randomized trial was carried out in 120 patients undergoing colonic surgery mainly for carcinoma. Sixty-one patients received metronidazole and Thalazole and 59 received Thalazole alone. Sepsis occurred in 8 (13.1 per cent) of the 61 patients who received metronidazole, compared with 29 (49.2 per cent) of 59 patients who received only Thalazole. Of the 8 patients with sepsis who received metronidazole, none had infection due to anaerobic organisms.
D000284:Administration, Oral; D002986:Clinical Trials as Topic; D003106:Colon / Q000601:surgery*; D006801:Humans; D008795:Metronidazole / Q000008:administration & dosage / Q000627:therapeutic use*; D011300:Preoperative Care / Q000379:methods; D011897:Random Allocation; D013432:Sulfathiazoles / Q000627:therapeutic use*; D013530:Surgical Wound Infection / Q000382:microbiology / Q000517:prevention & control*
D013432:Sulfathiazoles; D008795:Metronidazole