Studies on the experimental therapy of iridocyclitis.
Effectiveness of selected anti-inflammatory drugs on the experimental model of uveitis was evaluated. Studies on the biochemical parameters of inflammation in the aqueous humor and biomicroscopic evaluation of the clinical condition of the anterior chamber of the eye, carried out in the therapy course, allowed to establish the following order of the studied drugs, according to their therapeutical effectiveness (from the most effective): indomethacin greater than ibuprofen greater than hydrocortizone greater than 6-mercaptopurine.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001082:Aqueous Humor / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D006854:Hydrocortisone / Q000627:therapeutic use; D007052:Ibuprofen / Q000627:therapeutic use; D007213:Indomethacin / Q000627:therapeutic use; D008297:Male; D015122:Mercaptopurine / Q000627:therapeutic use; D009961:Orosomucoid / Q000378:metabolism; D010447:Peptide Hydrolases / Q000378:metabolism; D011453:Prostaglandins / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D011817:Rabbits; D012794:Sialic Acids / Q000378:metabolism; D014606:Uveitis, Anterior / Q000188:drug therapy*
D000893:Anti-Inflammatory Agents; D009961:Orosomucoid; D011453:Prostaglandins; D011506:Proteins; D012794:Sialic Acids; D015122:Mercaptopurine; D010447:Peptide Hydrolases; D006854:Hydrocortisone; D007052:Ibuprofen; D007213:Indomethacin