Immunological effect of co-trimoxazole on platelets.
Diminished survival of transfused platelets occurred in two patients given co-trimoxazole, and a third patient taking this drug developed thrombocytopenia. By means of an indirect immunofluorescence assay antibodies against donor platelets coated with co-trimoxazole were found in the sera in all cases. These antibodies were directed against the trimethoprim component of co-trimoxazole and not against sulphamethoxazole. Co-trimoxazole is a potent antimicrobial agent and is advocated for treatment and prophylaxis in leukaemia. Hence its adverse effect on platelets is of great importance.
D000328:Adult; D000906:Antibodies / Q000032:analysis; D001791:Blood Platelet Disorders / Q000139:chemically induced*; D001792:Blood Platelets / Q000276:immunology; D002470:Cell Survival / Q000187:drug effects; D004338:Drug Combinations; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D008297:Male; D013420:Sulfamethoxazole / Q000009:adverse effects*; D014295:Trimethoprim / Q000009:adverse effects*
D000906:Antibodies; D004338:Drug Combinations; D014295:Trimethoprim; D013420:Sulfamethoxazole