[Evaluation of H2 receptor blockade with metiamide in stress ulcers in rats].
Restrain stress in rats inhibits gastric secretion and microcirculation. Secretion is further inhibited by metiamide, but mucosal blood flow is restored to normal. During stress the ulcer incidence is high, lower with prophylactic administration of metiamide and least with the latter and preserved gastroduodenal acid transit. No therapeutic metiamide effect can be detected.
D000632:Aminopyrine / Q000378:metabolism; D000818:Animals; D005750:Gastric Juice / Q000378:metabolism; D005753:Gastric Mucosa / Q000098:blood supply / Q000378:metabolism; D008297:Male; D008785:Metiamide / Q000494:pharmacology / Q000627:therapeutic use*; D008833:Microcirculation; D010434:Pepsin A / Q000378:metabolism; D051381:Rats; D011968:Receptors, Histamine / Q000187:drug effects*; D011970:Receptors, Histamine H2 / Q000187:drug effects*; D012149:Restraint, Physical; D013276:Stomach Ulcer / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control*; D013312:Stress, Physiological / Q000150:complications*; D013890:Thiourea / Q000031:analogs & derivatives*
D011968:Receptors, Histamine; D011970:Receptors, Histamine H2; D000632:Aminopyrine; D008785:Metiamide; D010434:Pepsin A; D013890:Thiourea
Bewertung der H2-Receptorenblockade mit Metiamid beim Stressulcus der Ratte.