Cellular hypersensitivity to brain antigen in children of a family with hereditary ataxia.
Sensitisation to brain antigen was demonstrated in eight of 24 clinically normal first generation children in a family with hereditary ataxia. This ratio is consistent with that expected in a dominantly inherited condition. It suggests that immunological reactivity may precede the clinical expression of disease, with important implications for presymptomatic diagnosis and for pathogenesis of degenerative disease.
D000293:Adolescent; D000328:Adult; D001259:Ataxia / Q000235:genetics* / Q000276:immunology; D001323:Autoantibodies; D001921:Brain / Q000276:immunology*; D002648:Child; D005455:Fluorescent Antibody Technique; D006386:Hemagglutination Tests; D006801:Humans; D007111:Immunity, Cellular; D008263:Macrophage Migration-Inhibitory Factors / Q000032:analysis
D001323:Autoantibodies; D008263:Macrophage Migration-Inhibitory Factors