The significance of clinical assessment of brain tissue oxygenation in different pathological conditions: an overview.
The development of methods of measurement of brain oxygenation in man is reviewed and the possible clinical potential of some new and established laboratory techniques is evaluated. Advantages and problems associated with the various approaches are considered together with the difficulties that are encountered in interpretation of data obtained and the factors that may increase such difficulties. It is concluded that invasive techniques that can only be used intraoperatively are of limited value but may be helpful in confirming the edges of ischemic areas or the restoration of adequate local blood flow. Chronically implanted devices have been useful in detecting epileptic foci and in evaluation of anesthetic regimes in patients with brain lesions. Infrared spectroscopy may offer possibilities for noninvasive whole brain monitoring in patients, but the method lacks resolution.
D001921:Brain / Q000378:metabolism*; D001927:Brain Diseases / Q000378:metabolism*; D002545:Brain Ischemia / Q000378:metabolism; D002245:Carbon Dioxide / Q000378:metabolism; D002544:Cerebral Infarction / Q000378:metabolism; D004827:Epilepsy / Q000378:metabolism; D006801:Humans; D008991:Monitoring, Physiologic / Q000379:methods; D010092:Oximetry; D010100:Oxygen / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism
D002245:Carbon Dioxide; D011188:Potassium; D010100:Oxygen