The nature of the genetic determinant for the SHV-1 beta-lactamase.
In two unrelated plasmids of incompatibility groups FII and N the gene for the SHV-1 beta-lactamase exists as part of a transposable element of molecular weight 9.5 megadaltons. This transposon has moved onto plasmids of at least three incompatibility groups; PI, Ialpha and J. This confirms the suggestion that the recent spread of the SHV-1 beta-lactamase has been associated with the transposition of the genetic determinant of this enzyme between unrelated plasmids.
D001483:Base Sequence; D004262:DNA Restriction Enzymes / Q000378:metabolism; D004251:DNA Transposable Elements; D004269:DNA, Bacterial / Q000032:analysis / Q000378:metabolism; D004926:Escherichia coli / Q000235:genetics*; D007709:Klebsiella / Q000235:genetics*; D008970:Molecular Weight; D010957:Plasmids; D011513:Proteus mirabilis / Q000235:genetics*; D014169:Transformation, Bacterial; D001618:beta-Lactamases / Q000235:genetics*
D004251:DNA Transposable Elements; D004269:DNA, Bacterial; D004262:DNA Restriction Enzymes; D001618:beta-Lactamases