The effect of acidic polysaccharides and prostaglandin-like substances isolated from Propionibacterium acnes on granulocyte chemotaxis.
Three acidic polysaccharide (AP) fractions and the prostaglandin-like substances (PLS) isolated from P. acnes were investigated regarding their chemotactic activities on polymorphonuclear leukocytes. Both AP's and PLS induced a significant chemotatic response, which suggests their involvement in inflammatory acne vulgaris.
D002473:Cell Wall / Q000032:analysis; D002633:Chemotaxis / Q000187:drug effects*; D004926:Escherichia coli / Q000032:analysis; D006801:Humans; D008970:Molecular Weight; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology*; D011135:Polysaccharides, Bacterial / Q000494:pharmacology*; D011425:Propionibacterium acnes / Q000032:analysis*; D011453:Prostaglandins / Q000494:pharmacology*; D011458:Prostaglandins E / Q000494:pharmacology
D011135:Polysaccharides, Bacterial; D011453:Prostaglandins; D011458:Prostaglandins E