[Effect of methylprednisolone on bacterial infection of the peritoneal cavity in the guinea pig].
There is clinical proof of the decisive therapeutic effect of bolus injection of corticosteroids in septic shock. Our own studies, in which sublethal doses of bacterial suspensions were introduced into the peritoneal cavity of guinea pigs, demonstrate that a simultaneously applied solution of methylprednisolone (MP) has no influence on the intraperitoneal number of bacteria. Even the rapid initial decrease of bacterial counts, which, according to our studies, can be inhibited by Liquoid and is, therefore, caused by complement, is not influenced by the addition of MP. There was no indication of a change of tissue reactions in gut or mesenterium. The therapeutic effect of corticosteroids seems to depend on its influence on peripheral vessels.
D000818:Animals; D001202:Ascitic Fluid / Q000382:microbiology; D001424:Bacterial Infections / Q000188:drug therapy*; D004927:Escherichia coli Infections / Q000188:drug therapy; D006168:Guinea Pigs; D008775:Methylprednisolone / Q000627:therapeutic use*; D010538:Peritonitis / Q000188:drug therapy* / Q000473:pathology
D008775:Methylprednisolone
Zur Wirkung von Methyl-Prednisolon auf die bakterielle Infektion der Peritonealhöhle des Meerschweinchens.