Efficacy of bacampicillin and ampicillin in experimental pyelonephritis in the rat.
Bacampicillin and ampicillin were tested and compared with each other in a model of acute, obstructive pyelonephritis in the rat. The compounds were administered orally at five dose levels ranging from 50 mg/kg to 150 mg/kg. Bacampicillin was found to have a greater therapeutic activity than ampicillin, particulary at the higher doses, indicating that its improved absorption properties make it a therapeutically more effective compound than ampicillin.
D000667:Ampicillin / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D001437:Bacteriuria / Q000188:drug therapy; D004195:Disease Models, Animal; D004926:Escherichia coli / Q000187:drug effects; D004927:Escherichia coli Infections / Q000188:drug therapy*; D007668:Kidney / Q000382:microbiology; D011704:Pyelonephritis / Q000188:drug therapy*; D051381:Rats
D000667:Ampicillin