title: Fenfluramine, vitamin C and weight loss.
abstract: Forty-two female patients with refractory obesity completed a 20-week double-blind study during which they were given a diet designed to provide not more than 40 mg vitamin C and 1000 kcal (4.2 MJ) daily. Twenty-two of the patients took 600 mg of supplementary vitamin C daily and the remainder, a matched placebo. All were given their highest tolerated dose of fenfluramine up to a maximum of 160 mg daily. There was no significant difference in the mean weight loss of the two groups. This study fails to support the hypothesis that the anti-obesity effect of fenfluramine is influenced by the vitamin C intake.
mesh_terms: D000284:Administration, Oral; D001205:Ascorbic Acid / Q000008:administration & dosage*; D001835:Body Weight / Q000187:drug effects*; D002986:Clinical Trials as Topic; D004038:Diet, Reducing; D004311:Double-Blind Method; D004341:Drug Evaluation; D004347:Drug Interactions; D005260:Female; D005277:Fenfluramine / Q000627:therapeutic use*; D006801:Humans; D009765:Obesity / Q000188:drug therapy*; D010919:Placebos
chemical_list: D010919:Placebos; D005277:Fenfluramine; D001205:Ascorbic Acid