Interaction of oestradiol and gonadotrophin-releasing hormone on LH release in the mare.
Acyclic mare given oestradiol for 3 days to simulate the preovulatory plasma oestradiol surge showed a non-significant 37% decrease in plasma LH during treatment. When GnRH analogue injections were given with oestradiol on Days 1--3, oestradiol had no effect on each GnRH-induced LH increase, but LH increases were more prolonged following subsequent GnRH injections on Days 4--7 when oestradiol was no longer being given. A much greater prolongation of LH release occurred when the course of GnRH injections was commenced after oestradiol treatment ceased; the LH response was almost identical to the prolonged periovulatory LH surge of the normal cycle. Therefore, it appears that the timing of the oestradiol surge, in relation to other hormonal events, is critical in inducing the uniquely prolonged periovulatory LH surge of the mare.
D000818:Animals; D004347:Drug Interactions; D004958:Estradiol / Q000494:pharmacology*; D004971:Estrus / Q000187:drug effects; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology*; D006728:Hormones / Q000494:pharmacology; D006736:Horses / Q000502:physiology*; D007986:Luteinizing Hormone / Q000378:metabolism*; D010060:Ovulation / Q000187:drug effects; D011247:Pregnancy
D006728:Hormones; D007987:Gonadotropin-Releasing Hormone; D004958:Estradiol; D007986:Luteinizing Hormone