title: Evidence for the conversion of angiotensin I to angiotensin II by the coronary microcirculation.
abstract: Cardiac tissue from hamster neonates was transplanted into the hamster cheek pouch. After vascularization of the transplanted tissue the vessels were tested for their ability to convert angiotensin I (AI) to angiotensin II (AII). AI caused vasoconstriction of the coronary vessels which was reduced significantly by converting enzyme inhibitor and the AII antagonist (Sar1-Ala8) angiotensin II. It was concluded that the vessels of transplanted cardiac allografts convert AI to AII in a manner similar to that observed in the whole heart indicating that this procedure provides a good model for studying the microcirculation of the heart.
mesh_terms: D000803:Angiotensin I / Q000378:metabolism* / Q000494:pharmacology; D000804:Angiotensin II / Q000096:biosynthesis* / Q000494:pharmacology; D000809:Angiotensins / Q000378:metabolism*; D000818:Animals; D003331:Coronary Vessels / Q000378:metabolism*; D006224:Cricetinae; D005260:Female; D016027:Heart Transplantation; D008833:Microcirculation / Q000187:drug effects / Q000378:metabolism; D009200:Myocardial Contraction / Q000187:drug effects; D012504:Saralasin / Q000494:pharmacology; D014184:Transplantation, Homologous; D014661:Vasoconstriction / Q000187:drug effects
chemical_list: D000809:Angiotensins; D000804:Angiotensin II; D000803:Angiotensin I; D012504:Saralasin