Concentration of dicloxacillin and benzylpenicillin in fracture haematoma.
Prophylaxis with loading doses of dicloxacillin (3 patients) and benzylpenicillin (5 patients) has been used preoperatively for malleolar fractures treated in a standardized manner. Postoperatively, the same dose was given every 6 h for a total period of 48 h. The concentration of antibiotics was measured in serum before and after operation and 6 h after the first infusion. Samples from the haematoma were taken during operation and from the drainage collected during 24 h. Satisfactory concentrations were found in serum pre- and postoperatively and in the haematoma.
D000328:Adult; D000368:Aged; D016512:Ankle Injuries; D002986:Clinical Trials as Topic; D004009:Dicloxacillin / Q000032:analysis* / Q000097:blood / Q000627:therapeutic use; D004311:Double-Blind Method; D005260:Female; D005592:Fracture Fixation; D050723:Fractures, Bone / Q000150:complications*; D005596:Fractures, Closed / Q000150:complications*; D006406:Hematoma / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D007431:Intraoperative Complications / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D010400:Penicillin G / Q000032:analysis* / Q000097:blood / Q000627:therapeutic use; D011183:Postoperative Complications / Q000517:prevention & control; D014945:Wound Healing
D004009:Dicloxacillin; D010400:Penicillin G