Short term metronidazole therapy contrasted with povidone-iodine spray in the prevention of wound infection after appendicectomy.
In a prospective, randomized trial metronidazole was found to be significantly better than povidone-iodine in reducing the incidence of wound infection after appendicectomy (P less than 0.005). The metronidazole was given as a established 7-day course. Over 65 per cent of the wound infections presented after the patients had been discharged from hospital.
D000336:Aerosols; D001062:Appendectomy; D002648:Child; D002986:Clinical Trials as Topic; D006801:Humans; D008795:Metronidazole / Q000627:therapeutic use*; D011205:Povidone / Q000031:analogs & derivatives*; D011206:Povidone-Iodine / Q000627:therapeutic use*; D011897:Random Allocation; D013530:Surgical Wound Infection / Q000517:prevention & control*; D013997:Time Factors
D000336:Aerosols; D008795:Metronidazole; D011206:Povidone-Iodine; D011205:Povidone