Effect of preoperative administration of oxytetracycline and neomycin on the development of local tumour recurrences in cases of cancer coli-recti.
In the available literature some evidence has been shown, implying that antibiotic prophylaxis in connection with colorectal surgery might increase the frequency of local recurrences of the carcinoma. 134 patients undergoing elective curative surgery of the large bowel have been followed for 20-52 months. 66 patients had been pretreated with Enterobiotic; 68 patients were controls. In our study, we found no difference between the pretreated and non-pretreated group concerning the frequency of anastomotic suture line recurrences or other types of local recurrences in the operation field.
D000230:Adenocarcinoma / Q000601:surgery; D000368:Aged; D001424:Bacterial Infections / Q000517:prevention & control; D002986:Clinical Trials as Topic; D003106:Colon / Q000382:microbiology; D003110:Colonic Neoplasms / Q000601:surgery*; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009355:Neomycin / Q000008:administration & dosage / Q000627:therapeutic use*; D009364:Neoplasm Recurrence, Local; D009366:Neoplasm Seeding; D010118:Oxytetracycline / Q000008:administration & dosage / Q000627:therapeutic use*; D011300:Preoperative Care; D011897:Random Allocation; D012004:Rectal Neoplasms / Q000601:surgery*; D012306:Risk; D013530:Surgical Wound Infection / Q000517:prevention & control; D013607:Tablets
D013607:Tablets; D009355:Neomycin; D010118:Oxytetracycline