title: Fractionation of a mutagenic principle from broiled fish by high-pressure liquid chromatography.
abstract: A mutagenic principle present in the basic fraction of broiled sardines cooked in the ordinary way was fractionated by high-pressure liquid chromatography using a reversed-phase column. Results indicated that the major mutagenic principle is not identical with any of the mutagens previously isolated from amino acid pyrolysis products, and that a new, unidentified mutagen exists in broiled sardines.
mesh_terms: D000596:Amino Acids / Q000302:isolation & purification; D000818:Animals; D002243:Carbolines / Q000302:isolation & purification; D002851:Chromatography, High Pressure Liquid; D003296:Cooking; D005399:Fishes; D006358:Hot Temperature; D009153:Mutagens / Q000302:isolation & purification*; D012486:Salmonella typhimurium / Q000187:drug effects
chemical_list: D000596:Amino Acids; D002243:Carbolines; D009153:Mutagens