[Formation of an IgM and an IgG immune response depending on the redistribution of T- and B-subpopulations under the action of serotonin].
The syngeneic transfer of spleen cells or spleen and lymph node cells from donors with an elevated serotonin level stimulated, in comparison with the control animals, immune response in the recipients subjected to sublethal irradiation, which was manifested by an increase in the number of plaque-forming and rosette-forming cells. After the combined transfer of spleen cells and bone marrow cells from similar animals a decrease in the number of plaque-forming and rosette-forming cells was observed, while after the transfer of spleen and thymus cells the intensity of immune response remained unchanged. Serotonin was supposed to induce the redistribution of T and B cells in the non-immunized animals, so that suppressor cells migrated from the spleen and the lymph nodes to the bone marrow.
D000818:Animals; D000937:Antigen-Antibody Reactions / Q000187:drug effects*; D001402:B-Lymphocytes / Q000187:drug effects* / Q000637:transplantation; D006462:Hemolytic Plaque Technique; D007074:Immunoglobulin G / Q000276:immunology*; D007075:Immunoglobulin M / Q000276:immunology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D012397:Rosette Formation; D012701:Serotonin / Q000276:immunology*; D013601:T-Lymphocytes / Q000187:drug effects* / Q000637:transplantation; D014185:Transplantation, Isogeneic
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012701:Serotonin
Formirovanie IgM- i IgG-immunnogo otveta v zavisimosti ot pereraspredeleniia T- i B-subpopuliatsiĭ pod deĭstviem serotonina.