The effect of dietary disulfiram upon the tissue distribution and excretion of 14C-1,2-dibromoethane in the rat.
Dietary disulfiram enhances the toxicity of inhaled 1,2-dibromoethane in rats. This study was undertaken to determine whether the differential toxicity noted was associated with alterations in the levels of the compound and/or its metabolites in the target organs. A comparison of the levels of 14C in selected tissues of male rats, with and without dietary disulfiram, following the oral administration of 14C-1,2-dibromoethane was made. The results indicated that levels of radioactivity in the target organs of animals in  the disulfiram group were significantly elevated both at 24 and 48 hours following compound administration. The data indicate a direct correlation between tissue levels and the enhancement of toxicity noted in the disulfiram-treated rats in the inhalation study. A significant elevation in the levels of radioactivity in washed liver nuclei obtained from animals receiving dietary disulfiram was also noted, suggesting a relationship between nuclear uptake and the increased incidence of liver tumors appearing in the disulfiran group in the inhalation study.
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D004032:Diet; D004221:Disulfiram / Q000494:pharmacology* / Q000652:urine; D004347:Drug Interactions; D015946:Ethylene Dibromide / Q000378:metabolism*; D005243:Feces / Q000032:analysis; D006842:Hydrocarbons, Brominated / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D013997:Time Factors; D014018:Tissue Distribution
D006842:Hydrocarbons, Brominated; D015946:Ethylene Dibromide; D004221:Disulfiram