title: Growth hormone control of glucose oxidation pathways in hypophysectomized rats.
abstract: An in vivo response of glucose oxidation to growth hormone has been demonstrated. Hypophysectomized rats were found to oxidize glucose at rates significantly higher than normal rats. Treatment with growth hormone 1 h before injection of 14C-U-glucose, 14C-6-glucose, or 14C-1-glucose caused a return to a normal oxidation pattern. This acute response was independent of insulin action but clearly time-dependent since no change from untreated hypophysectomized rats appeared when growth hormone was given at various times prior to administration of labeled glucose. The response observed for 14C-6-glucose was comparable to that observed for 14C-1-glucose with regard to dynamics but differed with respect to total 14C recovered as 14CO2. The cumulative percent 14CO2 recovered from oxidation of 14C-6-glucose 1 h after growth hormone injection exceeded that recovered from oxidation of 14C-1-glucose. These results suggest a change in glucose oxidation by a route that cannot be explained solely by changes in either the hexose monophosphate or Embden-Meyerhof pathways.
mesh_terms: D000818:Animals; D005947:Glucose / Q000378:metabolism*; D013006:Growth Hormone / Q000494:pharmacology*; D007016:Hypophysectomy; D007328:Insulin / Q000494:pharmacology; D008297:Male; D010084:Oxidation-Reduction; D010902:Pituitary Gland / Q000502:physiology*; D011773:Pyruvates / Q000378:metabolism; D051381:Rats; D013997:Time Factors; D014535:Uridine Diphosphate Glucuronic Acid / Q000378:metabolism
chemical_list: D007328:Insulin; D011773:Pyruvates; D014535:Uridine Diphosphate Glucuronic Acid; D013006:Growth Hormone; D005947:Glucose