A new antigen on the epithelial membrane: its immunoperoxidase localisation in normal and neoplastic tissue.
Using antisera raised against defatted human cream we have demonstrated a new antigen on the epithelial membrane. An indirect immunoperoxidase technique on routinely processed histological sections was used, and we describe results which show that this antigen has a widespread but highly selective distribution, being apparently localised to membranes that have a secretory function. The antigen is carried by a variety of adenocarcinomas, suggesting that its localisation may have a role in the diagnosis and differential diagnosis of malignant disease.
D000941:Antigens / Q000032:analysis*; D000951:Antigens, Neoplasm / Q000032:analysis; D001940:Breast / Q000276:immunology*; D001943:Breast Neoplasms / Q000276:immunology; D002462:Cell Membrane / Q000276:immunology; D004848:Epithelium / Q000276:immunology; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008895:Milk, Human / Q000276:immunology; D009928:Organ Specificity
D000941:Antigens; D000951:Antigens, Neoplasm