Research in leprosy. A report of a committee set up by the medical research council to study future prospects.
Recommendations for future research in leprosy include (i) cultivation of M. leprae in vitro; (ii) genetic control of susceptibility, including twin studies and HLA typing; (iii) precise antigenic analysis of M. leprae; (iv) mechanisms involved in the macrophage response to mycobacterial infections; (v) more use of experimental models such as normal mice infected with M. lepraemurium; (vi) reassessment of the protection afforded by BCG; (vii) assessment of protection afforded by killed (armadillo) M. leprae vaccine; (viii) pathogenesis of erythema nodosum leprosum including a study of the effect of thalidomide; and (ix) development of in vitro systems for drug sensitivity testing.
D000818:Animals; D000942:Antigens, Bacterial; D001135:Armadillos; D001500:BCG Vaccine / Q000627:therapeutic use; D001428:Bacterial Vaccines / Q000627:therapeutic use; D004195:Disease Models, Animal; D004893:Erythema Nodosum / Q000276:immunology; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D007918:Leprosy / Q000188:drug therapy / Q000276:immunology / Q000517:prevention & control; D051379:Mice; D009166:Mycobacterium leprae / Q000276:immunology / Q000302:isolation & purification; D012106:Research
D000942:Antigens, Bacterial; D001500:BCG Vaccine; D001428:Bacterial Vaccines; D006680:HLA Antigens