title: Regulation of peptidoglycan biosynthesis in relA+ and relA- strains of Escherichia coli during diauxic growth on glucose and lactose.
abstract: In both relA+ and relA- derivatives, the biosynthesis of peptidoglycan, lipid intermediates, and nucleotide precursors abruptly halted at the onset of diauxic lag from glucose to lactose with a concomitant accumulation of guanosine 5'-diphosphate 3'-diphosphate (ppGpp). These results are consistent with the proposal that ppGpp is involved in inhibiting the incorporation of disaccharide-pentapeptide into peptidoglycan and in regulating nucleotide precursor synthesis.
mesh_terms: D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D006159:Guanosine Tetraphosphate / Q000096:biosynthesis; D007785:Lactose / Q000378:metabolism*; D009154:Mutation; D010457:Peptidoglycan / Q000096:biosynthesis*
chemical_list: D010457:Peptidoglycan; D006159:Guanosine Tetraphosphate; D005947:Glucose; D007785:Lactose