The role of plasmapheresis in renal transplantation.
Plasmapheresis has been studied in ten patients who received cadaveric renal allografts. In six patients (group A), plasma was carried out on the first post-operative day and then on alternate days until six treatments had been completed. No beneficial effect was observed but treatment was well tolerated and there were no complications. One patient retains a functioning graft. Plasma exchange was carried out on six consecutive days in five patients (group B) who were actively rejecting their grafts and in whom conventional methods of treatment had failed. All five patients showed improvement in graft function. Rejection was reversed in four patients and was contained in one patient. Subsequently rapid recrudescence of graft rejection occurred in one patient, extended graft survival was seen in two patients, and the other two patients have retained life supporting grafts. Plasmapheresis may have a part to play in the treatment of renal allograft rejection and further evaluation of this treatment is indicated.
D000906:Antibodies; D003165:Complement System Proteins / Q000032:analysis; D003404:Creatinine / Q000097:blood; D003601:Cytotoxicity Tests, Immunologic; D004231:Diuresis; D005260:Female; D006084:Graft Rejection; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D010956:Plasmapheresis; D014184:Transplantation, Homologous
D000906:Antibodies; D007136:Immunoglobulins; D003165:Complement System Proteins; D003404:Creatinine