title: Phenobarbital in prophylaxis of neonatal jaundice. A control trial of two regimens.
abstract: The prevention of neonatal hyperbilirubinemia by phenobarbital is widely used in many countries. However, dose and period of administration vary according to authors, as the dose-effect relation is not known and since little research in pharmacokinetics of phenobarbital has been done so far. In the present study we compared the effect on serum bilirubin of a single injection of 10 mg/kg body weight and of a prolonged administration of 10 mg/kg/day during 3 days in premature and full-term newborn infants. The single injection had the same effect as the prolonged administration, provided it was given within 12 h after birth.
mesh_terms: D001663:Bilirubin / Q000097:blood; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D006801:Humans; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000517:prevention & control*; D010634:Phenobarbital / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D001663:Bilirubin; D010634:Phenobarbital