title: The evaluation of hemorrhage in cardiac patients who have undergone extracorporeal circulation.
abstract: The present study defines excessive bleeding in patients who undergo cardiopulmonary bypass, and evaluates the use of coagulation testing to predict those patients that bleed excessively. Evaluation of 774 consecutive patients undergoing aortocoronary bypass surgery was carried out. Cardiopulmonary bypass consisted of a bloodless prime and a Harvey bubble oxygenator. In the postoperative period, excessive hemorrhage was defined as that exceeding 600 ml chest tube drainage in the first eight hours. One hundred and sixty-three patients (21%) were noted to be in this category. Excessive bleeding postoperatively was best predicted by a PTT greater than 45 seconds, a PT greater than 19 seconds, a fibrinogen level less than 225 mg/dl and a TFT equal to or less than 1:32. These laboratory findings occur singly or in combination. The assessment of platelet, numbers or function and fibrin(ogen) split products were of no prognostic value. Using these criteria, the re-exploration rate for excessive hemorrhage and/or tamponade was 0.6 per cent (5 out of 774 patients). No preoperative laboratory test of hemostatic function was useful in predicting coagulopathies resulting from cardiopulmonary bypass.
mesh_terms: D001431:Bacteriological Techniques; D001772:Blood Cell Count; D001792:Blood Platelets; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000150:complications / Q000628:therapy*; D005338:Fibrin Fibrinogen Degradation Products; D005340:Fibrinogen; D006385:Hemagglutination Inhibition Tests; D006400:Hematocrit; D006470:Hemorrhage / Q000150:complications*; D006801:Humans; D011517:Prothrombin Time
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; D005340:Fibrinogen