title: A comparison of the effects of endotoxin upon fibroblast proliferation and macromolecular syntheses.
abstract: The effects of Escherichia coli endotoxin upon mouse L929 cell proliferation, DNA synthesis, protein synthesis, and proline incorporation were determined. It was found that a level of endotoxin which inhibited cell proliferation prompted a similar inhibition of DNA synthesis and overall cell protein synthesis. In contrast, endotoxin was shown to inhibit incorporation of proline into cell protein to a significantly greater extent.
mesh_terms: D000818:Animals; D002448:Cell Adhesion; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis*; D004731:Endotoxins / Q000494:pharmacology*; D004926:Escherichia coli; D005347:Fibroblasts; D046911:Macromolecular Substances; D051379:Mice; D011392:Proline / Q000378:metabolism; D014176:Protein Biosynthesis
chemical_list: D004731:Endotoxins; D046911:Macromolecular Substances; D004247:DNA; D011392:Proline