Comparison of gastrointestinal effects of aspirin and fenoprofen. A double blind crossover study.
Sixteen men received 3904 mg of aspirin, 2400 mg of fenoprofen, or placebo daily for 1 week in a double blind and crossover trial. Fecal blood loss was measured by 51Cr labeled red cells; gastric and duodenal pathology were observed endoscopically. There was more (P less than 0.05) blood loss (4.96 ml) after aspirin than after fenoprofen (2.46 ml) or placebo (0.79 ml). By endoscopic examination, aspirin induced more (P less than 0.05) gastrointestinal pathology than fenoprofen or placebo, and there was a correlation of 0.70 between the two methods used in this study.
D000284:Administration, Oral; D000328:Adult; D001241:Aspirin / Q000008:administration & dosage / Q000633:toxicity*; D002986:Clinical Trials as Topic; D004386:Duodenum / Q000187:drug effects*; D004724:Endoscopy; D005279:Fenoprofen / Q000008:administration & dosage / Q000633:toxicity*; D005753:Gastric Mucosa / Q000187:drug effects*; D005756:Gastritis / Q000139:chemically induced*; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced*; D005773:Gastroscopy; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009780:Occult Blood; D010666:Phenylpropionates / Q000633:toxicity*; D010919:Placebos
D010666:Phenylpropionates; D010919:Placebos; D001241:Aspirin; D005279:Fenoprofen