Localization of IgE in adenoids and tonsils: an immunoperoxidase study.
An immunoperoxidase technique was applied to the localization of IgE in formaldehyde-solution-fixed, paraffin-embedded tissue. The content and distribution of IgE in tonsil and adenoid tissues from ten patients with histories of inhalant allergies and elevated serum levels of total and allergen-specific IgE were investigated. Compared with tissues from five nonatopic subjects, the tissues from atopic individuals were observed to harbor a much larger population of IgE-formating plasma cells. The profusion of IgE plasma cells in nasopharyngeal lymphoid tissue, observed in this study, furnishes strong anatomic evidence for a pathogenetic role of IgE in inhalant allergies. For cellular and tissue localization of IgE, the immunoperoxidase technique offers clear advantages over previously used immunoflorescence procedures.
D000234:Adenoids / Q000276:immunology* / Q000473:pathology; D006651:Histocytochemistry; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology* / Q000473:pathology; D007124:Immunoenzyme Techniques; D007073:Immunoglobulin E; D014066:Palatine Tonsil / Q000276:immunology* / Q000473:pathology
D007073:Immunoglobulin E