[Effect of hypothalamic lHRH (luliberin) on the electrical activity of isolated rat heart].
Decelerating effect of LH--RH upon the frequency of contraction of the rat isolated perfused heart was revealed. The neurohormone was also shown to change the heart electrical activity causing elongation of the systole due to an increase in repolarization period. Simultaneous application of LH--RH and norepinephrine to the rat isolated perfused heart did not alter the frequency of contractions. The LH--RH seems to take part in the regulation of the myocardium excitability by means of its effect on the membrane permeability for monovalent cations.
D000818:Animals; D004562:Electrocardiography; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D009638:Norepinephrine / Q000008:administration & dosage; D051381:Rats
D007987:Gonadotropin-Releasing Hormone; D009638:Norepinephrine
Vliianie LG--RG (liuliberina) gipotalamusa na élektricheskuiu aktivnost' izolirovannogo serdtsa krysy.