title: Phenazines with two cationic side chains as potential antimalarials.
abstract: 1,9-Phenazine-bis(dialkylaminocarboxamides) were prepared for screening as potential antimalarials. No significant activity against Plasmodium berghei was observed. The phenazine targets were prepared from 1,9-phenazinedicarboxylic acid by standard methods. The reaction between 1,9-phenazinedicarboxylic acid and thionyl chloride in the presence of dimethylformamide unexpectedly gave 4-chloro-1,9-phenazinedicarbonyl chloride.
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000627:therapeutic use; D008288:Malaria / Q000188:drug therapy; D008722:Methods; D010619:Phenazines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D010962:Plasmodium berghei
chemical_list: D000962:Antimalarials; D010619:Phenazines