Mutagenicity of aliphatic nitrosamines in Salmonella typhimurium.
25 aliphatic nitrosamines were examined in the Ames assay for bacterial mutagens, using rat liver "S-9" for activation. Of them, 8 carcinogens were mutagenic and 5 non-carcinogens were not mutagenic. However, 2 compounds not carcinogenic in rats were mutagenic and 9 carcinogens were not mutagenic, including 6 that are liver carcinogens in rats.
D002273:Carcinogens / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005821:Genetic Techniques; D009153:Mutagens / Q000494:pharmacology; D009602:Nitrosamines / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000235:genetics
D002273:Carcinogens; D009153:Mutagens; D009602:Nitrosamines