title: Histological and immunohistological studies on gastric mucosa. I. The presence of CEA in dysplastic surface epithelium.
abstract: Surface and foveolar gastric cells (SE) of 74 gastric resection specimens were studied by classical and indirect immunoenzyme histology. Immunoadsorbed CEA-antibodies reacting only with the specific determinant of of the CEA molecule were applied. The following SE types with different CEA distribution patterns were observed: Type SE-O, no CEA, normal neutral mucosubstances (MCS); type SE-A, CEA present in the lower half of the SE, important decrease of MCS, mild cell dysplasia by conventional criteria; type SE-B, CEA present in the total cell, absence of MCS, moderate until marked dysplasia; type SE-C, CEA present or decreased, absence of MCS, very important cell dysplasia resembling cancer cells. CEA proved to be useful as marker for the degree of SE dysplasia.
mesh_terms: D002272:Carcinoembryonic Antigen / Q000032:analysis*; D005753:Gastric Mucosa / Q000032:analysis / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D013274:Stomach Neoplasms / Q000276:immunology*
chemical_list: D002272:Carcinoembryonic Antigen