title: The antiarrhythmic action of prostacyclin (PGI2) on aconitine induced arrhythmias in rats.
abstract: Prostacyclin (PGI2) produces an antiarrhythmic effect on aconitine induced arrhythmias in rats. The ED50 of PGI2 was 0.7 microgram/kg and the maximum antiarrhythmic effect 54 per cent. The equi-effective doses of PGE2 and PGF2alpha were higher (ED50 of PGF2alpha = 1.2 microgram/kg, ED50 of PGE2 = 2.7 microgram/kg). However, PGF2alpha and PGE2 had a maximum antiarrhythmic effect of 80 per cent in this model.
mesh_terms: D000157:Aconitine; D000818:Animals; D001146:Arrhythmia, Sinus / Q000139:chemically induced / Q000503:physiopathology; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000503:physiopathology*; D011464:Epoprostenol / Q000494:pharmacology*; D005260:Female; D006321:Heart / Q000187:drug effects / Q000503:physiopathology*; D008297:Male; D011453:Prostaglandins / Q000494:pharmacology*; D051381:Rats
chemical_list: D011453:Prostaglandins; D011464:Epoprostenol; D000157:Aconitine