[Reactive changes in the hypothalamus after implantation of bipolar insulated electrodes and electrostimulation of the adenohypophyseotropic zone].
Histological changes were studied in the hypothalamus of cats in a stereotaxic implantation into the middle zone of bipolar electrodes both by electrostimulation and without it. A wider zone of pathology is localized near the active surface of electrodes, around which a layer capsule is formed and which is surrounded externally by a zone of reactive gliosis. In conditions of electrostimulation quite frequently figures of mitosis of hypertrophied astrocytes are encountered. There is a definite increase of the neuroglial index. Different signs of neuron pathology of the conductive and secretory types, neuron fibres and synapses were found. The described changes were more intense in experiments of 7--15 day electrostimulation. On the 60th day the reactive-destructive process drops, however, the morphological changes in the tissue elements of the hypothalamic area may be marked in all the parts. The extensive pathology in the midbrain develops not only due to a trauma of the hypothalamus during electrode implantation and electrostimulation, but most likely under the influence of the growing capsule as an "alien body". Owing to this factor the changes in the midbrain persist even during the late periods of experiments without electrostimulation.
D000818:Animals; D001808:Blood Vessels / Q000473:pathology; D002415:Cats; D004556:Electric Injuries / Q000473:pathology*; D004558:Electric Stimulation / Q000009:adverse effects*; D004567:Electrodes, Implanted; D005260:Female; D005549:Foreign-Body Reaction / Q000473:pathology*; D005911:Gliosis; D007031:Hypothalamus / Q000293:injuries / Q000473:pathology; D007249:Inflammation; D008297:Male; D013997:Time Factors
Reaktivnye izmeneniia gipotalamusa pri vzhivlenii bipoliarnykh izolirovannykh élektrodov i élektrostimuliatsii adenogipofizotropnoĭ zony.