The development of an implantable electrochemical glucose sensor: response to glucose in bovine serum ultrafiltrate.
A glucose sensor based on organic oxidation reactions at a platinum electrode is being developed as the key component for an implantable artificial beta cell for diabetic patients. Sensitivity of a membrane-covered platinum electrode to changing glucose concentration in bovine serum ultrafiltrate has been demonstrated, with current response as high as 60 microamperes per 100 mg/dl change in glucose concentration. Reproducibility of measurements probably will depend on satisfactory mechanical assembly of the membrane-electrode combination. An approach to selectivity based on multiple current measurements is suggested.
D000818:Animals; D001187:Artificial Organs; D001322:Autoanalysis / Q000295:instrumentation / Q000379:methods; D001786:Blood Glucose / Q000032:analysis*; D002417:Cattle; D003920:Diabetes Mellitus / Q000097:blood; D004566:Electrodes; D006801:Humans; D007515:Islets of Langerhans / Q000378:metabolism; D014462:Ultrafiltration
D001786:Blood Glucose