title: Concentrations of phenobarbital, flurazepam, and flurazepam metabolites in autopsy cases.
abstract: In five cases of death resulting from acute intoxication with phenobarbital and flurazepam, the blood, urine, brain, lung, liver,  and kidney levels of these drugs as well as the levels of N-1 hydroxyethyl, N-1 desalkyl, and N-1 desalkyl-3-hydroxy flurazepam metabolites were determined. Concentration of flurazepam and its metabolites was determined by using new gas chromatographic conditions employing a selective detector for nitrogen-containing substances and a column of 1% SP-1000. In addition, the EMIT technique was also employed on blood and urine samples and the results compared with GLC data.
mesh_terms: D000328:Adult; D000368:Aged; D001344:Autopsy; D002675:Child, Preschool; D002849:Chromatography, Gas; D005260:Female; D005479:Flurazepam / Q000032:analysis* / Q000378:metabolism; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D010634:Phenobarbital / Q000032:analysis*; D013405:Suicide
chemical_list: D005479:Flurazepam; D010634:Phenobarbital