title: Soluble antigens released in vitro from erythrocytes infected with Plasmodium berghei.
abstract: Rat erythrocytes parasitized with Plasmodium berghei were found to release soluble antigenic products in vitro. The supernatants obtained by centrifugation of the disrupted cells induced specific transformation of non-adherent spleen lymphocytes of convalescent rats and produced precipitation lines with antiplasmodial antibodies. In a preliminary experiment they also immunized young rats against a viable challenge of P. berghei. It is suggested that the soluble material could serve for the purification of an effective protective antigen.
mesh_terms: D000818:Animals; D004912:Erythrocytes / Q000469:parasitology*; D007519:Isoantigens / Q000378:metabolism*; D008288:Malaria / Q000276:immunology*; D010962:Plasmodium berghei / Q000276:immunology; D051381:Rats; D012995:Solubility
chemical_list: D007519:Isoantigens