title: [Doxycycline bioavailability in capsules].
abstract: Soviet doxycycline capsules in a dose of 0.1 g were studied in vitro (for disintegration and solubility) and in vivo (pharmacokinetics on 25 patients). It was found that Soviet doxycycline capsules provided comparatively rapid absorption of doxycycline. The antibiotic availability may be characterized by the solubility test. The results of the study on bioavailability of Soviet doxycycline capsules were compared with the results of analogous studies published by American authors for doxycycline capsules manufactured by various firms of the USA.
mesh_terms: D000042:Absorption; D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D002214:Capsules; D002986:Clinical Trials as Topic; D004318:Doxycycline / Q000378:metabolism*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D008875:Middle Aged; D012995:Solubility; D013997:Time Factors
chemical_list: D002214:Capsules; D004318:Doxycycline
vernacular_title: Biodostupnost' doksitsiklina v kapsulakh.