Analogues of [3H] chloramphenicol for photoaffinity labeling.
The synthesis of [3H]chloramphenicol and its erythro-diastereoisomer with specific activities of 1.25 Ci/mmol, and the further transformation of the [3H]chloramphenicol to a series of azido and diazo-substituted derivatives are described. The antibiotic activity of the compounds was considered insufficient for their use as photoaffinity labels.
D000345:Affinity Labels; D055598:Chemical Phenomena; D002621:Chemistry; D002701:Chloramphenicol / Q000031:analogs & derivatives* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D007553:Isotope Labeling / Q000379:methods; D012270:Ribosomes / Q000187:drug effects; D014316:Tritium
D000345:Affinity Labels; D014316:Tritium; D002701:Chloramphenicol