Role of the kidney in the inactivation rate constant of urokinase activity.
The role of the kidney in the inactivation rate constant of UK activity (ke) was examined experimentally. The results obtained were as follows. There was a remarkable divergence in FA between the abdominal aorta and renal vein. When the bilateral renal arteries and veins were ligated, ke was 0.38, in contrast to 0.79 in the normal state. When UK was infused into rabbits with ligated renal vessels, the FA lasted for an increased period after the termination of UK infusion. These findings suggest that the kidney functions as an inactivator of UK.
D000818:Animals; D001012:Aorta, Abdominal / Q000502:physiology; D004423:Ear / Q000098:blood supply; D010450:Endopeptidases / Q000502:physiology*; D005342:Fibrinolysis; D006400:Hematocrit; D007668:Kidney / Q000098:blood supply / Q000502:physiology*; D008099:Liver / Q000098:blood supply; D011817:Rabbits; D012082:Renal Veins / Q000502:physiology; D013154:Spleen / Q000098:blood supply; D014568:Urokinase-Type Plasminogen Activator / Q000502:physiology*
D010450:Endopeptidases; D014568:Urokinase-Type Plasminogen Activator