[T- and B-lymphocyte changes in lymphogranulomatosis].
Under study were T- and B-systems of immunity in patients with lymphogranulomatosis, and these were correlated with clinical findings (the stage, intoxication, the effect of chemotherapy). Blastransformation reaction (RBT) with phytohemagglutinin (PHA), direct blasttransformation with sheep erythrocytes, immunofluorescence were estimated. The absolute amount of lymphocytes in 1 ml and also T- and B-cells were counted. Already in the stage I--II there was noted a reduction in the amount of T-lymphocytes and RBT to PHA. These changes in cell immunity were aggravated in the stage III B and stage IV B in particular. After the chemotherapy conducted according to the MOPP programme in most patients the immunological background would be more unfavourable. There was noted a relationship between the immune indice stability during chemotherapy for lymphogranulomatosis and the duration of remission.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001402:B-Lymphocytes / Q000276:immunology*; D005260:Female; D005455:Fluorescent Antibody Technique; D006689:Hodgkin Disease / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D007958:Leukocyte Count; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology*
Izmeneniia T- i B-limfotsitov u bol'nykh limfogranulematozom.