The epoxide hydratase inducer trans-stilbene oxide shifts the metabolic epoxidation of benzo(a)pyrene from the bay- to the K-region and reduces its mutagenicity.
D000818:Animals; D001580:Benzopyrenes / Q000378:metabolism*; D055598:Chemical Phenomena; D002621:Chemistry; D004790:Enzyme Induction / Q000187:drug effects; D004851:Epoxide Hydrolases / Q000096:biosynthesis*; D066298:In Vitro Techniques; D008297:Male; D006899:Mixed Function Oxygenases / Q000378:metabolism; D009153:Mutagens / Q000378:metabolism*; D051381:Rats; D012486:Salmonella typhimurium / Q000235:genetics; D013267:Stilbenes / Q000494:pharmacology*
D001580:Benzopyrenes; D009153:Mutagens; D013267:Stilbenes; D006899:Mixed Function Oxygenases; D004851:Epoxide Hydrolases