Mutagenic activity of chemical carcinogens and related compounds in the intraperitoneal host-mediated assay.
The mutagenic activities of 79 carcinogens, noncarcinogens, and structurally related compounds toward Salmonella typhimurium strains TA1530, TA1535, and TA1538 and toward Saccharomyces cerevisiae D3 were investigated in the intraperitoneal host-mediated assay. Fewer than half of the carcinogens were mutagenic toward the Salmonella strains. The insensitivity of the system was most marked with the aromatic amine and polycyclic hydrocarbon procarcinogens. Under the test conditions, fewer than 10% of the carcinogens showed clear mutagenic activity toward S. cerevisiae D3. However, none of the noncarcinogens was significantly mutagenic toward either S. typhimurium or S. cerevisiae D3. Overall, the intraperitoneal host-mediated assay does not seem suitable for routine preliminary screening of large numbers of potential carcinogens. The median lethal doses to mice of 46 compounds were determined.
D000477:Alkylating Agents / Q000494:pharmacology; D000588:Amines / Q000494:pharmacology; D000818:Animals; D001681:Biological Assay; D002273:Carcinogens / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D006834:Hydrazines / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D009153:Mutagens; D009603:Nitroso Compounds / Q000494:pharmacology; D011083:Polycyclic Compounds / Q000494:pharmacology; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D012486:Salmonella typhimurium / Q000187:drug effects
D000477:Alkylating Agents; D000588:Amines; D002273:Carcinogens; D006834:Hydrazines; D009153:Mutagens; D009603:Nitroso Compounds; D011083:Polycyclic Compounds