Pharmacological and clinical aspects of some drugs used in peptic ulcer treatment.
A healing effect of carbenoxolone and colloidal bismuth on gastric and duodenal ulcer has been demonstrated in several studies. The use of carbenoxolone is limited by the high frequency of side effects. Information on the ability of these drugs to prevent ulcer recurrences is sparse. Further studies are needed to determine the ulcer-healing effect of deglycyrrhizinised liquorice. Sulpiride, a dopamine-blocking agent, seems to have interesting inhibitory effects on gastric secretion but its anti-ulcer activity is not yet clear.
D000897:Anti-Ulcer Agents; D001570:Benzodiazepinones / Q000009:adverse effects / Q000627:therapeutic use; D001729:Bismuth / Q000627:therapeutic use; D002229:Carbenoxolone / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006035:Glycyrrhiza; D006801:Humans; D010437:Peptic Ulcer / Q000188:drug therapy*; D010879:Piperazines / Q000009:adverse effects / Q000627:therapeutic use; D010946:Plants, Medicinal; D013469:Sulpiride / Q000627:therapeutic use
D000897:Anti-Ulcer Agents; D001570:Benzodiazepinones; D010879:Piperazines; D013469:Sulpiride; D002229:Carbenoxolone; D001729:Bismuth