Kinetics of cell kill by hyperthermia.
A review of published reports showed that there was surprisingly good agreement between different authors on the heat sensitivity of a particular cell line. For several cell lines, there was a marked difference in the heat of inactivation above 43 degrees (deltaH = 148 kcal/mol) and below 43 degrees (deltaH = 365 kcal/mol). This may indicate different mechanisms of cell killing above and below this temperature. With all cell lines tested, M- and S-phase cells were much more heat sensitive than were G1 or G2 cells. The heat sensitivity of S-phase cells is in contrast to the resistance of these cells to X-rays. The effect of hyperthermia on cell progression is discussed. The possibility of greater sensitivity of neoplastic cells to hyperthermia as compared to normal cells seems very promising.
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D002453:Cell Cycle; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D006224:Cricetinae; D004317:Doxorubicin / Q000008:administration & dosage; D006367:HeLa Cells; D006358:Hot Temperature / Q000627:therapeutic use*; D007700:Kinetics; D007939:Leukemia L1210 / Q000628:therapy; D008325:Mammary Neoplasms, Experimental / Q000628:therapy; D051379:Mice; D009374:Neoplasms, Experimental / Q000628:therapy*
D000970:Antineoplastic Agents; D004317:Doxorubicin