Delayed-type hypersensitivity responses in mice infected with St. Louis encephalitis virus: kinetics of the response and effects of immunoregulatory agents.
Labeled monocyte infiltration techniques have been used to study delayed-type hypersensitivity responses in mice immunized with St. Louis encephalitis virus. A delayed 24- to 48-h inflammatory response occurred 6 to 7 days after immunization. This response can be potentiated by cyclophosphamide treatment, by BCG administration, or by splenectomy. Treatments known to selectivity inhibit T-cell function suppressed the response.
D000818:Animals; D000917:Antibody Formation; D001500:BCG Vaccine; D003520:Cyclophosphamide / Q000494:pharmacology; D004665:Encephalitis Virus, St. Louis; D004674:Encephalitis, St. Louis / Q000276:immunology*; D006968:Hypersensitivity, Delayed / Q000276:immunology* / Q000473:pathology; D007111:Immunity, Cellular; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D009000:Monocytes / Q000276:immunology; D009163:Mycobacterium bovis / Q000276:immunology; D010835:Phytohemagglutinins / Q000494:pharmacology; D013997:Time Factors
D001500:BCG Vaccine; D010835:Phytohemagglutinins; D003520:Cyclophosphamide