[Enzyme cytochemical and immunocytological differentiation of infiltrative cells in the skin in mycosis fungoides].
In 4 patients with mycosis fungoides in the praemycotic, infiltrative and tumour stage of the disease, a differentiation and functional characterization of the infiltrate cells, obtained from cell suspensions and cutaneous smears, was carried out by means of enzyme cytochemical and immunological methods. The lymphocyte-associated acid esterase is considered to be a marker for mature T-cell populations. Apart from monocytes and histiocytes, acid esterase-positive small lymphocytoid cells with T-cell properties are found in the praenycotic stage. In the tumour stage, large lymphocytoid cells become increasingly prevalent, they show no acid esterase activity, but an intracytoplasmatic-localized reaction in the acid phosphatase activity. On the basis of the cytochemical pattern, it is assumed that these cells represent proliferating lymphoblasts.
D000135:Acid Phosphatase / Q000378:metabolism; D004950:Esterases / Q000378:metabolism*; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D008213:Lymphocyte Activation; D009182:Mycosis Fungoides / Q000201:enzymology / Q000276:immunology / Q000473:pathology*; D011947:Receptors, Antigen, B-Cell; D012867:Skin / Q000201:enzymology / Q000473:pathology*; D012878:Skin Neoplasms / Q000201:enzymology / Q000276:immunology / Q000473:pathology*; D013601:T-Lymphocytes / Q000201:enzymology / Q000276:immunology*
D011947:Receptors, Antigen, B-Cell; D004950:Esterases; D000135:Acid Phosphatase
Enzymzytochemische und immunzytologische Differenzierung von Infiltratzellen in der Haut bei Mycosis fungoides.