title: The Brompton mixture versus morphine solution given orally: effects on pain.
abstract: The Brompton mixture is widely used as an effective method for controlling pain in cancer patients. In a double-blind crossover trial a standard Brompton mixture containing morphine, cocaine, ethyl alcohol, syrup BP and chloroform water was compared with morphine alone in a flavoured aqueous solution; both were administered orally. Pain was measured by means of the pain intensity index of the McGill Pain Questionnaire. Ratings of confusion, nausea and drowsiness were obtained from both the patients and their nurses and relatives. The data showed that there was no significant difference between the Brompton mixture and morphine administered orally for any of the variables. Both relieved pain effectively in about 85% of the patients.
mesh_terms: D000284:Administration, Oral; D000700:Analgesics / Q000009:adverse effects / Q000627:therapeutic use; D002725:Chloroform / Q000008:administration & dosage*; D002986:Clinical Trials as Topic; D003042:Cocaine / Q000008:administration & dosage*; D003061:Codeine; D003221:Confusion / Q000139:chemically induced; D004311:Double-Blind Method; D004338:Drug Combinations; D004341:Drug Evaluation; D000431:Ethanol / Q000008:administration & dosage*; D006801:Humans; D009020:Morphine / Q000008:administration & dosage*; D009325:Nausea / Q000139:chemically induced; D009369:Neoplasms / Q000150:complications; D010148:Intractable Pain / Q000188:drug therapy* / Q000209:etiology; D010640:Phenothiazines / Q000008:administration & dosage; D012894:Sleep Stages / Q000187:drug effects
chemical_list: D000700:Analgesics; D004338:Drug Combinations; D010640:Phenothiazines; D000431:Ethanol; C020234:Brompton mixture; D009020:Morphine; D002725:Chloroform; D003042:Cocaine; D003061:Codeine