title: Cartilage and osteoarthrosis: changes of collagen and proteoglycans.
abstract: The authors discuss changes of proteoglycans and collagen in osteoarthrotic cartilage, based on their own results. During osteoarthrosis the proteoglycan molecule diminishes in size, mainly due to a diminution of the carbohydrate portion. The diminution of binding glycoprotein leads to changes in the interaction with hyaluronic acid. Collagen is more soluble and has a reduced resistance to proteolytic enzymes. In the osteoarthrotic cartilage also collagen type I and III is present.
mesh_terms: D050260:Carbohydrate Metabolism; D002358:Cartilage, Articular / Q000201:enzymology / Q000378:metabolism*; D003094:Collagen / Q000378:metabolism*; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D006820:Hyaluronic Acid / Q000378:metabolism; D010003:Osteoarthritis / Q000201:enzymology / Q000378:metabolism*; D010447:Peptide Hydrolases / Q000378:metabolism; D011509:Proteoglycans / Q000378:metabolism*
chemical_list: D006023:Glycoproteins; D011509:Proteoglycans; D006820:Hyaluronic Acid; D003094:Collagen; D010447:Peptide Hydrolases