[Biological properties of synthetic somatostatin].
Complex work on the assessment of biological properties of somatostatin synthesized according to a new original method was carried out. Its inhibitory action on the TTH, growth hormone and insulin secretion was demonstrated in vivo and in vitro. As a rule, somatostatin effect was expressed against the background of stimulated hormone secretion, although basal secretion inhibition was observed with respect to insulin, The inhibitory action of somatostatin on the hormonal secretion was direct, not mediated through any regulating factors.
D000818:Animals; D002478:Cells, Cultured; D003864:Depression, Chemical; D005260:Female; D006728:Hormones / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010903:Pituitary Gland, Anterior / Q000187:drug effects* / Q000378:metabolism; D011388:Prolactin / Q000378:metabolism; D051381:Rats; D013004:Somatostatin / Q000494:pharmacology*; D013972:Thyrotropin / Q000378:metabolism
D006728:Hormones; D007328:Insulin; D013004:Somatostatin; D011388:Prolactin; D013972:Thyrotropin
Issledovanie biologicheskikh svoĭstv sinteticheskogo somatostatina.