title: Clinical application of pre-programmed insulin infusion: continuous subcutaneous insulin therapy with a portable infusion system.
abstract: Strict control of blood glucose was achieved by continuous subcutaneous insulin infusion with a specially adapted Mill Hill Infuser for 3-4 days. This led to normalisation of some of the intermediary metabolites. In a few patients, subcutaneous infusions have been carried out for periods up to 3 months with home monitoring of blood glucose, without infection or lipodystrophy. Short-term improvement of metabolic control was associated with recovery of abnormal renal glomerular permeability to albumin.
mesh_terms: D000409:Alanine / Q000097:blood; D001187:Artificial Organs; D001786:Blood Glucose / Q000032:analysis; D003920:Diabetes Mellitus / Q000188:drug therapy*; D005246:Feedback; D006801:Humans; D007263:Infusions, Parenteral; D007328:Insulin / Q000008:administration & dosage / Q000627:therapeutic use*; D007515:Islets of Langerhans / Q000378:metabolism*
chemical_list: D001786:Blood Glucose; D007328:Insulin; D000409:Alanine