title: The delayed effect of sodium valproate on the photoconvulsive response in man.
abstract: The acute effect of a single oral dose of sodium valproate on the photoconvulsive response has been studied. In 7 of 9 patients naive to this drug photosensitivity was abolished or reduced. A similar effect was seen in only 2 of 7 already receiving chronic sodium valproate therapy. The effect appeared 1 to 5 hr (mean, 3 hr) after attainment of peak sodium valproate concentration and lasted up to 5 days.
mesh_terms: D000293:Adolescent; D000328:Adult; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010775:Photic Stimulation; D012640:Seizures / Q000188:drug therapy* / Q000209:etiology; D013997:Time Factors; D014635:Valproic Acid / Q000627:therapeutic use*
chemical_list: D014635:Valproic Acid