The comparative efficacy of buspirone and diazepam in the treatment of anxiety.
In this double-blind study, 56 adult psychoneurotic outpatients with a primary diagnosis of anxiety neurosis were randomly assigned to receive buspirone (N = 18), diazepam (N = 20), or placebo (N = 18) over a four-week period. A battery of tests administered weekly indicated that buspirone, a new agent not chemically related to any currently marketed drugs, was as effective an antianxiety agent as diazepam and produced no more and perhaps fewer side effects. Buspirone showed excellent antidepressant effects as well. If further studies confirm the authors' findings and determine that buspirone does not result in tolerance and addiction, it would be more advantageous than the benzodiazepines in the treatment of anxiety.
D000328:Adult; D001008:Anxiety Disorders / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D003975:Diazepam / Q000627:therapeutic use*; D004311:Double-Blind Method; D004341:Drug Evaluation; D004361:Drug Tolerance; D006801:Humans; D008875:Middle Aged; D011581:Psychological Tests; D011743:Pyrimidines / Q000627:therapeutic use*; D013141:Spiro Compounds / Q000627:therapeutic use*; D014149:Tranquilizing Agents / Q000627:therapeutic use*
D011743:Pyrimidines; D013141:Spiro Compounds; D014149:Tranquilizing Agents; D003975:Diazepam