[Therapy of traumatic brain edema with spironolactone (author's transl)].
In 30 patients with severe brain injury a double-blind study was performed. The effectiveness of the aldosterone-antagonist Aldactone pro injectione was examined in therapy of traumatic brain edema. The results indicate elimination of sodium and water from brain cells and white matter. Concomitantly faster improvement of state of consciousness was observed.
D000293:Adolescent; D000328:Adult; D001921:Brain / Q000378:metabolism; D001929:Brain Edema / Q000188:drug therapy* / Q000209:etiology; D001930:Brain Injuries / Q000150:complications*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D010919:Placebos; D012964:Sodium / Q000097:blood; D013148:Spironolactone / Q000627:therapeutic use*; D014882:Water-Electrolyte Balance
D010919:Placebos; D013148:Spironolactone; D012964:Sodium
Zur Therapie des posttraumatischen Hirnödems. Doppelblindversuch mit Spironolacton.