title: [Structural organization of the juxtaglomerular complex of the kidney and its changes in the modelling of renovascular hypertension].
abstract: While studying a normal juxtaglomerular complex (JGC) under light optic and electron microscope, histotopographic dependence in distribution of its components in the renal cortical substance was stated. In normal periglomerular cells, processes of synthesis and excretion of renine granules are taking place that is demonstrated by the presence of young maturing, mature forms and subsequent excretion of their contents. In 157 rats during the development of experimental renovascular hypertension, correlation of the JGC of various classes of granularity was increasing towards the latter. Hyperfunction of the periglomerular cells is dynamically performed transferring from the accumulative type into the secretory one; this is proved by both changing in granularity index and correlation in stages of granule formation and excretion of their contents. Juxtavascular cells (Goormaghtigh's cells) and mesangiocytes are the reserve for renine production. Cellular reaction of macula densa is manifested in metaplasia of epitheliocytes of the distal part of the nephron, in increasing index of macula densa and in ultrastructural changes.
mesh_terms: D000818:Animals; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D004195:Disease Models, Animal; D006965:Hyperplasia / Q000473:pathology; D006977:Hypertension, Renal / Q000473:pathology*; D006978:Hypertension, Renovascular / Q000209:etiology / Q000473:pathology*; D007606:Juxtaglomerular Apparatus / Q000098:blood supply / Q000473:pathology* / Q000648:ultrastructure; D008854:Microscopy, Electron; D051381:Rats; D012083:Renin / Q000502:physiology; D013997:Time Factors
chemical_list: D012083:Renin
vernacular_title: Strukturnaia organizatsiia iukstaglomeruliarnogo kompleksa pochki i ego izmeneniia pri modelirovanii renovaskuliarnoĭ gipertonii.