title: [Examination of leg volume of patients for determining the therapeutic effect of 1-phenylephrine hydrochloride (author's transl)].
abstract: Distorsions and other injuries of a more or less grave kind are often found in combination with exudative processes. The anti-exudative effect of adequate drugs has so far been tested only on the rat paw oedema. As results gained from animal tests cannot immediately be applied to man, tests with human subjects were carried out. With a device by Diebschlag it has become possible to fulfil the demands of a simple but still exact measuring process for quantification of leg volumes. 12 subjects with a distorsion of the ankle joint were treated with a gel (active substance: 1-phenylephrine HCl) which reduces the volue of the leg and with a similar placebo gel, and the effects of both treatments were compared and examined. The analysis of data yielded statistically highly significant values for the effectivity of the active substance gel.
mesh_terms: D000328:Adult; D002986:Clinical Trials as Topic; D004487:Edema / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D007866:Leg / Q000473:pathology*; D008297:Male; D010656:Phenylephrine / Q000627:therapeutic use*; D010919:Placebos; D013997:Time Factors
chemical_list: D010919:Placebos; D010656:Phenylephrine
vernacular_title: Volumenuntersuchung der unteren Extremität von Patienten zur Wirkungsprüfung von 1-Phenylephrin-HCl.