Effects of bacterial products on granulopoiesis.
Methylated endotoxin and Freeman-type polysaccharide each stimulate granulopoiesis and the production of CSF in mice. These same preparations also protect pretreated mice from lethal X-irradiation. The role of CSF in stimulating granulopoiesis in vivo was shown by the ability of anti-CSF to reduce the number of CFUc in endotoxin-treated mice. C3H/HeJ low responder mice cannot be protected against lethal X-irradiation by pretreatment with endotoxin and they fail to produce CSF in response to phenol water extracted endotoxin and the Freeman-type polysaccharide, but do respond to trichloroacetic acid endotoxin with elevated serum CF levels.
D000818:Animals; D002473:Cell Wall; D003114:Colony-Forming Units Assay; D003115:Colony-Stimulating Factors / Q000097:blood / Q000494:pharmacology; D004731:Endotoxins / Q000494:pharmacology; D004926:Escherichia coli / Q000276:immunology; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000187:drug effects; D006918:Hydroxyurea / Q000494:pharmacology; D051379:Mice; D011135:Polysaccharides, Bacterial / Q000494:pharmacology; D012486:Salmonella typhimurium / Q000276:immunology; D013997:Time Factors
D003115:Colony-Stimulating Factors; D004731:Endotoxins; D011135:Polysaccharides, Bacterial; D006918:Hydroxyurea