[Detection and study of the labile toxic factor of Proteus mirabilis].
The author studied the dynamics of toxin formation of the high- and low-virulent Pr. mirabilis strains. The high-virulent strain produced toxic substances of the exotoxin type detectable in 1-2-day broth cultures. Later the activity of the culture medium of both cultures under study was due to substances of the endotoxin type. By physico-chemical and immunobiological properties, and also by chemical composition of Pr. mirabilis "early toxin" was similar to the exoenterotoxins of enterobacteria. A principal possibility of concentration and purification of Pr. mirabilis "early toxin" with the use of ultrafiltration and gel-chromatography was demonstrated.
D000818:Animals; D001427:Bacterial Toxins / Q000276:immunology / Q000302:isolation & purification*; D001428:Bacterial Vaccines / Q000276:immunology; D055598:Chemical Phenomena; D002621:Chemistry; D002850:Chromatography, Gel; D004731:Endotoxins / Q000302:isolation & purification; D004768:Enterotoxins / Q000302:isolation & purification; D007116:Immunization, Passive; D011512:Proteus Infections / Q000517:prevention & control; D011513:Proteus mirabilis / Q000032:analysis*; D011817:Rabbits
D001427:Bacterial Toxins; D001428:Bacterial Vaccines; D004731:Endotoxins; D004768:Enterotoxins
Obnaruzhenie i izuchenie labil'nogo toksicheskogo faktora Proteus mirabilis.