Effect of 7-alpha methoxy substitution of cephalosporins upon their affinity for the penicillin-binding proteins of E. coli K12. Comparison with antibacterial activity and inhibition of membrane bound model transpeptidase activity.
D000217:Acyltransferases / Q000037:antagonists & inhibitors*; D001426:Bacterial Proteins / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism*; D002462:Cell Membrane / Q000201:enzymology; D002511:Cephalosporins / Q000378:metabolism* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D010406:Penicillins / Q000378:metabolism; D010458:Peptidyl Transferases / Q000037:antagonists & inhibitors*; D011485:Protein Binding; D013329:Structure-Activity Relationship
D001426:Bacterial Proteins; D002352:Carrier Proteins; D002511:Cephalosporins; D010406:Penicillins; D000217:Acyltransferases; D010458:Peptidyl Transferases