Spontaneous diabetes mellitus: reversal and prevention in the BB/W rat with antiserum to rat lymphocytes.
Injections of rabbit antiserum to rat lymphocytes reversed hyperglycemia in 36 percent of spontaneously diabetic rats (Bio Breeding/Worcester) and prevented diabetes in susceptible nondiabetic controls. These findings strengthen the hypothesis that cell-mediated autoimmunity plays a role in the pathogenesis of diabetes in this animal model that mimics many morpholigic and physiologic characteristics of human insulin-dependent diabetes mellitus.
D000818:Animals; D000961:Antilymphocyte Serum / Q000627:therapeutic use*; D001327:Autoimmune Diseases; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000276:immunology* / Q000517:prevention & control / Q000628:therapy; D007165:Immunosuppression Therapy; D007515:Islets of Langerhans / Q000276:immunology; D007518:Isoantibodies; D008214:Lymphocytes / Q000276:immunology*; D051381:Rats
D000961:Antilymphocyte Serum; D001786:Blood Glucose; D007518:Isoantibodies