[Substrate specificity of peptidases catalyzing LH-RH degradation in hypothalamus, liver and heart of rat].
Degradation of [125I]-LH-RH by peptidases of hypothalamus, liver and heart of the rat and the effects of LH-RH, LH-RH antagonist D-Phe2-Phe3-D-Phe6-LH-RH, LH-RH5-10, oxytocin, bradikinin, thyrotrophin-releasing hormone, melanocyte-inhibiting factor, luteinizing, follicle-stimulating, lactogenic and growth hormones were studied. It was shown that the degradation was inhibited with maximal efficiency by non-labelled LH-RH (Ki = 1,7--2,0 . 10(-6) M). This observation is indicative of peptidase specificity for LH-RH. It is assumed that specific peptidases of liver and heart are involved in the reglation of LH-RH concentration in these organs.
D000818:Animals; D007987:Gonadotropin-Releasing Hormone; D006728:Hormones; D007031:Hypothalamus / Q000201:enzymology*; D007700:Kinetics; D008099:Liver / Q000201:enzymology*; D009206:Myocardium / Q000201:enzymology*; D010447:Peptide Hydrolases / Q000378:metabolism*; D051381:Rats; D013379:Substrate Specificity
D006728:Hormones; D007987:Gonadotropin-Releasing Hormone; D010447:Peptide Hydrolases
Izuchenie cubstratnoĭ spetsifichnosti peptidaz gipotalamusa, pecheni i serdtsa krys, rasshchepliaiushchikh liuliberin.