Regression of a transplanted guinea pig hepatoma after intralesional injection of an emulsified mixture of endotoxin and mycobacterial sulfolipid.
Mycobacterial sulfatides (sulfolipids) in admixture with endotoxin had tumor regressive activity comparable to trehalose-6,6'-dimycolate (TDM) and endotoxin in guinea pigs, but unlike TDM were neither toxic nor granulomagenic and had no antitumor activity in mice. The increased endotoxin lethality in mice pretreated with BCG was not observed in mice pretreated with sulfolipids or TDM instead of BCG.
D000818:Animals; D001428:Bacterial Vaccines / Q000627:therapeutic use* / Q000633:toxicity; D004655:Emulsions; D004731:Endotoxins / Q000627:therapeutic use*; D007167:Immunotherapy; D008114:Liver Neoplasms, Experimental / Q000628:therapy*; D008297:Male; D051379:Mice; D009161:Mycobacterium / Q000276:immunology; D009368:Neoplasm Transplantation; D012486:Salmonella typhimurium / Q000276:immunology; D013433:Sulfoglycosphingolipids / Q000627:therapeutic use*
D001428:Bacterial Vaccines; D004655:Emulsions; D004731:Endotoxins; D013433:Sulfoglycosphingolipids