Uncontrolled PGI2 production by whole vessel wall segments due to thrombin generation in vivo and its prevention by heparin.
D000818:Animals; D001011:Aorta / Q000378:metabolism; D001095:Arachidonic Acids / Q000494:pharmacology; D001808:Blood Vessels / Q000378:metabolism*; D004727:Endothelium / Q000648:ultrastructure; D011464:Epoprostenol / Q000096:biosynthesis*; D006493:Heparin / Q000494:pharmacology*; D011453:Prostaglandins / Q000096:biosynthesis*; D011817:Rabbits; D013917:Thrombin / Q000096:biosynthesis*; D014684:Venae Cavae / Q000378:metabolism
D001095:Arachidonic Acids; D011453:Prostaglandins; D006493:Heparin; D011464:Epoprostenol; D013917:Thrombin