[In vivo study of the effects of i.v. immunoglobulin therapy. Tissue distribution of native and enzyme-treated human immunoglobulin fractions given i.v. in man].
The tissue distribution of intravenously injected native and enzyme-treated human gammaglobulin has been investigated in human rectum mucosa. FITC-labelled antibodies to human gammaglobulin were used to locate the injected antibody preparation. Three hours after application of these different gammaglobulin-preparations no enrichment in the mucosa was found. Neither the native gammaglobulin nor the enzyme-treated gammaglobulin showed any concentration in the lamina propria of the large bowel mucosa or an intracellular enrichment in the epithel. This study shows that the quicker elimination of enzyme-treated gamma-globulin from the circulation cannot be explained by an intracellular increase.
D000818:Animals; D002986:Clinical Trials as Topic; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000008:administration & dosage / Q000378:metabolism*; D007074:Immunoglobulin G / Q000008:administration & dosage / Q000378:metabolism*; D007275:Injections, Intravenous; D008297:Male; D011817:Rabbits / Q000276:immunology; D014018:Tissue Distribution
D007140:Immunoglobulin Fab Fragments; D007074:Immunoglobulin G
In vivo-Studie zur Wirksamkeit der i.v. Immunglobulin-Therapie. Gewebeverteilung von nativem und Enzym-behandeltem i.v. applizierten Human-Immunglobulin-Fraktionen beim Menschen.