Effects of prenatal fenoterol, phenobarbitone and dexamethasone administration on the total phospholipid content of amniotic fluid.
The effect of prenatally administered phenobarbitone, fenoterol (a beta-sympathomimetic drug) and dexamethasone on fetal pulmonary maturity, as measured by the total phospholipid (TPL) content of amniotic fluid, was assessed. Compared with control values, there was a significantly greater rise after fenoterol (P less than 0,01) and dexamethasone (P less than 0,01), but not after phenobarbitone administration. The ability of dexamethasone to convert the TPL value to mature levels (greater than or equal 2,0 microgram/ml) was significantly greater than that of fenoterol (P less than 0,05).
D000653:Amniotic Fluid / Q000032:analysis / Q000378:metabolism; D002986:Clinical Trials as Topic; D003907:Dexamethasone / Q000494:pharmacology*; D004983:Ethanolamines / Q000494:pharmacology*; D005260:Female; D005280:Fenoterol / Q000494:pharmacology*; D006801:Humans; D006819:Hyaline Membrane Disease / Q000517:prevention & control; D007231:Infant, Newborn; D010634:Phenobarbital / Q000494:pharmacology*; D010743:Phospholipids / Q000032:analysis / Q000378:metabolism*; D011247:Pregnancy
D004983:Ethanolamines; D010743:Phospholipids; D005280:Fenoterol; D003907:Dexamethasone; D010634:Phenobarbital