title: Toxaphene, a complex mixture of polychloroterpenes and a major insecticide, is mutagenic.
abstract: Toxaphene, the most widely used chlorinated insecticide, is mutagenic in the Salmonella test without requiring liver homogenate for activity. This insecticide is a complex mixture (more than 177 polychloroterpenes) with carcinogenic activity in rodents. Some but not all of the mutagenic components are easily separated from the insecticidal ingredients.
mesh_terms: D004305:Dose-Response Relationship, Drug; D007306:Insecticides / Q000494:pharmacology*; D009153:Mutagens; D009154:Mutation; D012486:Salmonella typhimurium / Q000187:drug effects; D014112:Toxaphene / Q000494:pharmacology*
chemical_list: D007306:Insecticides; D009153:Mutagens; D014112:Toxaphene