The major product of PGG2 metabolism by aortic microsomes is 6, 15-dioxo-PGF1 alpha.
Incubations of PGG2 with aortic microsomes yielded two products which were not formed in boiled enzyme control, one of which was 6-oxo-PGF1 alpha. The major metabolite was identified by gas-liquid chromatography-mass spectrometry as 6,15-dioxo-PGF1 alpha. Thus, unlike PGH2, PGG2 is probably converted to 15-hydroperoxy PGI2 which subsequently decomposes to 6, 15-dioxo-PGF1 alpha.
D000818:Animals; D001011:Aorta / Q000166:cytology / Q000378:metabolism; D001158:Arteries / Q000166:cytology / Q000378:metabolism*; D011464:Epoprostenol / Q000378:metabolism; D008401:Gas Chromatography-Mass Spectrometry; D008861:Microsomes / Q000378:metabolism*; D011449:Prostaglandin Endoperoxides / Q000378:metabolism*; D011460:Prostaglandins F / Q000096:biosynthesis*; D011462:Prostaglandins G / Q000378:metabolism*; D013552:Swine
D011449:Prostaglandin Endoperoxides; D011460:Prostaglandins F; D011462:Prostaglandins G; D011464:Epoprostenol