Reconstruction of full-thickness loss skin wounds using skin collagen allografts.
Sheets of allogeneic dermal collagen measuring 20 X 15 mm and prepared by trypsin treatment of full-thickness skin were grafted under skin flaps in rats. After 2 to 5 weeks the protective recipient skin was excised and replaced by split-thickness skin isografts which remained viable on their supportive collagen beds. On average such composite grafts maintained 84 per cent of their original size over 3 to 28 weeks and in contrast with split-thickness skin grafts achieved full-thickness reconstruction of the excised skin.
D000818:Animals; D003094:Collagen; D003238:Connective Tissue / Q000033:anatomy & histology / Q000637:transplantation*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000033:anatomy & histology; D016038:Skin Transplantation; D014184:Transplantation, Homologous; D014947:Wounds and Injuries / Q000601:surgery*
D003094:Collagen