[Double blind clinical study of mianserin and nortriptyline (author's transl)].
The present study was done in double blind during 6 weeks on 36 depressed patients having a minimal score of 15 on the Hamilton rating scale. Seventeen received mianserin and nineteen nortriptyline. A comparable therapeutic efficacy was observed for both drugs, without significant differences for the delay of action or the activity during 6 weeks. The number of side-effects was much more elevated for nortriptyline, and a significant difference was particularly observed for the frequency and severity of tachycardia, dry mouth and oedema.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D003863:Depression / Q000188:drug therapy*; D003984:Dibenzazepines / Q000627:therapeutic use*; D004311:Double-Blind Method; D004341:Drug Evaluation; D004361:Drug Tolerance; D004487:Edema / Q000139:chemically induced; D005260:Female; D006801:Humans; D008297:Male; D008803:Mianserin / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D009661:Nortriptyline / Q000009:adverse effects / Q000627:therapeutic use*; D011569:Psychiatric Status Rating Scales; D013610:Tachycardia / Q000139:chemically induced; D014987:Xerostomia / Q000139:chemically induced
D003984:Dibenzazepines; D008803:Mianserin; D009661:Nortriptyline
Etude clinique comparative en double insu de la mianserine et de la nortriptyline.