title: The distribution and localization of immunoglobulin in the gastric mucosa and gastric cancer.
abstract: The distribution and localization of immunoglobulin in the gastric mucosa and gastric cancer were studied by means of immunofluorescence. In the lamina propria of the stomach, like the other parts of the gastrointestinal tract, IgA producing cells predominated, but their population density varied from case to case. The main portion of secretion of IgA in the stomach was deep foveolar epithelium. IgA containing epithelial cells in the stomach were much less than those in the intestine, but they increased with advancement of intestinal metaplasia. Some gastric cancer cells retained the ability of secretory component production and took up IgA in their cytoplasm.
mesh_terms: D000921:Antibody-Producing Cells / Q000473:pathology; D002452:Cell Count; D004848:Epithelium / Q000276:immunology; D005455:Fluorescent Antibody Technique; D005753:Gastric Mucosa / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis*; D007422:Intestines / Q000276:immunology; D012635:Secretory Component / Q000032:analysis; D013274:Stomach Neoplasms / Q000276:immunology*; D014018:Tissue Distribution
chemical_list: D007070:Immunoglobulin A; D007136:Immunoglobulins; D012635:Secretory Component