Inhibition of 6-phosphogluconate dehydrogenase (decarboxylating) by glucose 1,6-bisphosphate.
Glucose 1,6-bisphosphate, the powerful common regulator of several key enzymes in carbohydrate metabolism, was found to exert a potent inhibitory effect on the activity of 6-phosphogluconate dehydrogenase (decarboxylating) from yeast and several rat tissues. These findings suggest that glucose 1,6-bisphosphate may have a regulatory influence on the pentose phosphate pathway.
D000818:Animals; D003653:Decarboxylation; D005947:Glucose / Q000378:metabolism; D005958:Glucosephosphates / Q000494:pharmacology*; D008297:Male; D010428:Pentosephosphates / Q000378:metabolism; D010734:Phosphogluconate Dehydrogenase / Q000037:antagonists & inhibitors*; D051381:Rats; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D014018:Tissue Distribution
D005958:Glucosephosphates; D010428:Pentosephosphates; D010734:Phosphogluconate Dehydrogenase; D005947:Glucose