Prediction of solute transport during peritoneal dialysis.
Solute transport, predominantly diffusion, across the peritoneum correlates inversely with molecular weight. Provided that the solute is water soluble, not protein bound, not of unusual density, not ionized, does not have a large hydration shell, and is transported from plasma to dialysate, the peritoneal clearance is predictable over the molecular weight range from 60 to 11,000 daltons. Transport reates that deviate from the predicted can be explained by known physical properties of particular solutes.
D000818:Animals; D004058:Diffusion; D005227:Fatty Acids / Q000097:blood; D006801:Humans; D008970:Molecular Weight; D010530:Peritoneal Dialysis; D010710:Phosphates / Q000097:blood; D011485:Protein Binding; D011817:Rabbits; D012996:Solutions; D001613:beta 2-Microglobulin / Q000378:metabolism
D005227:Fatty Acids; D010710:Phosphates; D012996:Solutions; D001613:beta 2-Microglobulin