[Anosmia and hypogonadism (Kallman's or Maestre de San Juan's syndrome (author's transl)].
A patient, aged 15 years and three months, with hypogonadism and anosmia (Kallman's syndrome or Maestre de San Juan's syndrome) is presented. It is an sporadic case, with no associated abnormalities, who had been seen due to a lack of sexual development. Basal levels of plasmatic LH and FSH were lower than the sensitivity threshold of the method: 1.5 mlU/ml. Administration of 100 ng of GnRH alone in one dose did not evoke any change of these levels; when the same dosage was given during five consecutive days, plasmatic levels of both gonadotropins increased. Initial treatment with HCG (5,000 IU, biweekly) evoked very favourable changes in somatic and genital development.
D000293:Adolescent; D006063:Chorionic Gonadotropin / Q000627:therapeutic use; D005058:Eunuchism / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D007006:Hypogonadism / Q000175:diagnosis* / Q000188:drug therapy; D007275:Injections, Intravenous; D008297:Male; D000857:Olfaction Disorders / Q000175:diagnosis* / Q000188:drug therapy; D010906:Pituitary Hormone-Releasing Hormones / Q000627:therapeutic use; D013577:Syndrome
D006063:Chorionic Gonadotropin; D010906:Pituitary Hormone-Releasing Hormones
Hipogonadismo y anosmia (síndrome de Kallman o síndrome de Maestre de San Juan).