Development of a closed-loop artificial pancreas.
A closed-loop glucose controlled insulin infusion system was developed, consisting of elements for continuous blood glucose analysis, a computer control system, and infusion systems. Improvements include decreased size, cost reduction and better performance. The algorithm used was a piecewise linear representation of the sigmoidal curve commonly employed. The apparatus has been applied to simulation of the healthy beta cell and glucose clamp studies.
D001187:Artificial Organs; D001322:Autoanalysis; D001786:Blood Glucose / Q000032:analysis*; D003201:Computers; D003920:Diabetes Mellitus / Q000188:drug therapy*; D004435:Eating; D005246:Feedback; D006801:Humans; D007263:Infusions, Parenteral; D007328:Insulin / Q000008:administration & dosage* / Q000627:therapeutic use; D007515:Islets of Langerhans / Q000378:metabolism*
D001786:Blood Glucose; D007328:Insulin