[Morphofunctional characteristics of the pancreas in the progeny from females with experimental hypothyroidism].
Histophysiological pancreatic indices were studied in 1-, 21- and 30-day-old offsprings of white non-lineal female rats that were given antithyreoid drug mercasolil in the dose 3 mg/kg of body weight during pregnancy and lactation. Chemical inhibition of maternal thyreoid function results in decreasing weight index of the offspring's pancreas, in decreasing section area of the terminal secretory parts, in narrowing the homogenous zone of exocrine pancreocytes, in decreasing the portion occupied by the endocrine part on the section area, as well as in decreasing the index of B/A cells ratio of pancreatic islands and of nuclear volume of basophilic insulocytes. It is possible to conclude from the data obtained that maternal hypothyreosis produced by mercasolil unfavourably affects the process of structural and functional setting and the status of the pancreas in the offspring.
D000818:Animals; D005260:Female; D007037:Hypothyroidism / Q000139:chemically induced / Q000503:physiopathology*; D007515:Islets of Langerhans / Q000187:drug effects / Q000503:physiopathology; D008713:Methimazole / Q000008:administration & dosage; D010179:Pancreas / Q000187:drug effects / Q000503:physiopathology*; D011247:Pregnancy; D051381:Rats; D013997:Time Factors
D008713:Methimazole
Morfunktsional'naia kharakteristika podzheludochnoĭ zhelezy potomstva ot samok s éksperimental'nym gipotireozom.