Therapeutic value of anticonvulsant drugs in poisonings with an organophosphate.
Therapeutic effects of phenytoin, pentobarbital, diazepam, trimethadione and phensuximide given as an adjuvant to atropine and obidoxime in fluostigmine intoxication were studied in the rat. It was stated that only trimethadione significantly elevated the LD50 value for fluostigmine in animals treated with atropine and obidoxime. None of the tested anticonvulsants raised the LD10 value above the LD90 value in animals treated only with atropine and obidoxime.
D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D001285:Atropine / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005260:Female; D007531:Isoflurophate / Q000037:antagonists & inhibitors / Q000506:poisoning; D009768:Obidoxime Chloride / Q000627:therapeutic use; D062025:Organophosphate Poisoning; D009943:Organophosphorus Compounds / Q000037:antagonists & inhibitors; D051381:Rats
D000927:Anticonvulsants; D009943:Organophosphorus Compounds; D007531:Isoflurophate; D009768:Obidoxime Chloride; D001285:Atropine