Attempts of bone induction by xenogeneic epithelial cells in sublethally and lethally irradiated mice. Preliminary report.
Contrary to non-irradiated mice, no heterotopic bone formation was observed in sublethally (700 R) irradiated animals. In animals lethally irradiated (850 R) and protected with syngeneic bone marrow, a bone induction can be observed. The induction is weaker and infrequent when inducing cells are administered 2 weeks after irradiation and repopulation, and a cortisone was given at the time of epithelial cell grafting, than when the inducing cells were given immediately after irradiation and repopulation, and no cortisone was administered.
D000818:Animals; D001846:Bone Development / Q000528:radiation effects; D016026:Bone Marrow Transplantation; D001842:Bone and Bones / Q000528:radiation effects; D003348:Cortisone / Q000494:pharmacology; D004285:Dogs; D004848:Epithelium / Q000637:transplantation*; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D011828:Radiation Chimera; D014183:Transplantation, Heterologous; D014184:Transplantation, Homologous
D003348:Cortisone