Effects of BCG, levamisole and PS-K on the rejection of male skin grafts by female mice.
Rejection of male skin grafts by BALB/c female mice was accelerated by one s.c. injection of BCG (5 X 10(5) microorganisms/mouse) into recipients on the day of transplantation. Levamisole 20 mg/kg injected similarly was without any effect. Protein-bound polysaccharide Kureha (PS-K) injected 250 mg/kg s.c. or i.p. once every other day from the day of transplantation stimulated graft rejection. The s.c. route was more effective than the i.p. route. These results show that, in sex-linked graft rejection in mice, PS-K has an immunostimulant action similar to that of BCG. This property may be important to the antineoplastic activity of PS-K.
D000818:Animals; D001500:BCG Vaccine / Q000494:pharmacology*; D001835:Body Weight; D002471:Cell Transformation, Neoplastic; D005260:Female; D006084:Graft Rejection; D007111:Immunity, Cellular / Q000187:drug effects; D007274:Injections, Intraperitoneal; D007279:Injections, Subcutaneous; D007978:Levamisole / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009026:Mortality; D011134:Polysaccharides / Q000494:pharmacology*; D016038:Skin Transplantation; D014184:Transplantation, Homologous
D001500:BCG Vaccine; D011134:Polysaccharides; D007978:Levamisole