The antithrombotic activity of BAY g 6575.
The activity of 1-[2-(beta-naphthyloxy)ethyl]-3-methyl-2-pyrazolin-5-one (= BAY g 6575) was evaluated in models of experimental thrombosis caused by traumatically induced damage of vessel segments. After prophylactic administration of BAY g 6575 (0.3 mg/kg p.o.) to rats the thrombus formation was significantly reduced in the carotid artery as well as in the jugular vein. The thrombus formation in the femoral arteries of rabbits is inhibited at a minimal effective dose of 1 mg/kg p.o. The incidence of occlusive thrombi is not influenced. BAY g 6575 is 10 times more potent than acetylsalicylic acid (ASA). In the arterial system the thrombus formation is frequently completely abolished.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D001808:Blood Vessels / Q000187:drug effects; D003018:Clot Retraction; D011464:Epoprostenol / Q000096:biosynthesis; D005342:Fibrinolysis; D005343:Fibrinolytic Agents; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D011720:Pyrazoles / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D013916:Thrombelastography; D013931:Thromboxanes / Q000096:biosynthesis; D013997:Time Factors
D005343:Fibrinolytic Agents; D011720:Pyrazoles; D013931:Thromboxanes; D011464:Epoprostenol