title: Early functional and morphologic vascular renal consequences of the diabetic state.
abstract: Renal hyperfunction and hypertrophy are characteristic findings in the early diabetic state, both in diabetes mellitus and in experimental diabetes. A number of structure-function relationships and their likely mechanisms are discussed. The metabolically induced hypertrophy of glomerular capillaries possibly plays a central role. Its cause is not known, but recent results on its time-course emphasize the probable long-term consequences of the irreversibility of the accumulation of basement membrane material.
mesh_terms: D000419:Albuminuria; D003920:Diabetes Mellitus / Q000503:physiopathology; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology; D003925:Diabetic Angiopathies / Q000503:physiopathology*; D003928:Diabetic Nephropathies / Q000503:physiopathology*; D005919:Glomerular Filtration Rate; D005934:Glucagon; D006801:Humans; D007328:Insulin; D007668:Kidney / Q000503:physiopathology
chemical_list: D007328:Insulin; D005934:Glucagon