Effects of HLA-A and B matching on success of cadaver grafts at a single center.
The effect of HLA matching on the success of cadaver renal allografts was examined utilizing computerized multifactoral analysis in a large single renal transplant center. One hundred ninety-one consecutive cadaver transplant recipients (from January 1968 to August 1975) were followed from 2 1/2 to 9 years. During the period surveyed we had not utilized the tissue typing results in a prospective manner to select recipients. The data presented attest to the beneficial effect of utilizing well matched cadaver grafts. HLA matching of two or more antigens results in significantly superior 2- and 4-year patient survival and graft function compared to results for cadaver kidneys matched for zero and one HLA antigen. The results are not greatly influenced when age, sex, or time of transplant are controlled. The importance of tissue typing is particularly clear if higher doses of antilymphoblast globulin (ALG) are administered. The risk inherent in advancing recipient age is markedly reduced by better transplant matches. Graft function is also superior in the diabetic patients receiving good HLA matches, but there are too few patients to make these results statistically significant.
D058186:Acute Kidney Injury / Q000401:mortality; D000328:Adult; D000375:Aging; D000961:Antilymphocyte Serum / Q000627:therapeutic use; D002102:Cadaver; D002874:Chromosome Mapping; D003429:Cross Reactions; D003920:Diabetes Mellitus / Q000276:immunology; D005260:Female; D006085:Graft Survival; D006650:Histocompatibility Testing; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D013997:Time Factors; D014184:Transplantation, Homologous
D000961:Antilymphocyte Serum