Age variation in the increase of hypothalamic and brain stem contents of phenylethanolamine m-octopamine and p-octopamine in spontaneously hypertensive rats (SH Kyoto).
Phenylethanolamine, m-octopamine and p-octopamine contents were determined as a function of age in the hypothalamus and brain stem of spontaneously hypertensive rats and controls Wistar Kyoto. In hypothalamus, the content of the 3 amines was 2--4-fold greater for the SH rats. In the brain stem, the phenylethanolamine and p-octopamine contents were 2--3-fold greater in SH rats but 5--6-fold higher in the case of m-octopamine. The difference appears at 3 weeks and correlates the blood pressure with the increase of age. The significance of these findings is discussed.
D015078:2-Hydroxyphenethylamine / Q000031:analogs & derivatives / Q000378:metabolism*; D000375:Aging; D000818:Animals; D001933:Brain Stem / Q000254:growth & development / Q000378:metabolism*; D005260:Female; D006973:Hypertension / Q000378:metabolism*; D007031:Hypothalamus / Q000254:growth & development / Q000378:metabolism*; D009655:Octopamine / Q000378:metabolism* / Q000031:analogs & derivatives; D010627:Phenethylamines / Q000378:metabolism*; D051381:Rats
D010627:Phenethylamines; D009655:Octopamine; D015078:2-Hydroxyphenethylamine; C005310:norfenefrine