Pharmacological investigation on asclepin--a new cardenolide from Asclepias curassavica. Part II. Comparative studies on the inotropic and toxic effects of asclepin, g-strophantin, digoxin and digitoxin).
The cardiac effects of asclepin, a new glycoside from the plant Asclepias curassavica, were studies in vitro (isolated atrium and heart of guineapig) and in vivo (anaesthetized cat) and were compared with g-strophanthin, digoxin, digitoxin, or digitoxigenin, resp. Asclepin showed a marked positive inotropic effect as evidenced by the increase in the force of contraction, measured by (dp/dt)max and (formula: see text). It was found to be more active than the other glycosides.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002298:Cardenolides / Q000494:pharmacology* / Q000633:toxicity; D002301:Cardiac Glycosides / Q000494:pharmacology* / Q000633:toxicity; D002415:Cats; D002986:Clinical Trials as Topic; D004073:Digitoxigenin / Q000494:pharmacology; D004074:Digitoxin / Q000494:pharmacology; D004077:Digoxin / Q000494:pharmacology; D005260:Female; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D010042:Ouabain / Q000494:pharmacology; D013997:Time Factors
D002298:Cardenolides; D002301:Cardiac Glycosides; D004073:Digitoxigenin; D010042:Ouabain; D004077:Digoxin; D004074:Digitoxin