Carcinogenicity of endrin.
Endrin is carcinogenic for rats, and most likely also for mice and dogs. Endrin caused significant incidences of malignant neoplasms at all sites. In one study, female rats were susceptible to the development of neoplasms of the endocrine organs, particularly carcinomas of the adrenal and pituitary glands as well as neoplasms of the reproductive system. In other studies, female rats tended to have carcinomas of the endocrine system, the mammary gland and reproductive system, and male and female rats lymphomas. Rats developed unusual malignant neoplasms, such as Kupffer cell sarcomas of the liver and sarcomas of the mammary gland, uterus, and stomach. There also were toxic changes, particularly in male rats, ingesting endrin. These lesions included interstitial fibrosis of the kidney; polyarteritis of the mesenteric, pancreatic and other arteries; and atrophy of the testes. Such lesions generally interfere with the health of the rats and with the development of neoplasms. Dog receiving endrin for two years had bone marrow hyperplasia, lesions of the thyroid gland and lesions of the skeletal muscle, and hyperplasias or neoplasms of other organs. One female dog had an early carcinoma of the thyroid gland. Mice ingesting endrin developed increased incidences of carcinomas of the liver and sarcomas of the uterus.
D000236:Adenoma / Q000139:chemically induced; D000310:Adrenal Gland Neoplasms / Q000139:chemically induced; D000818:Animals; D001855:Bone Marrow Diseases / Q000139:chemically induced; D002273:Carcinogens; D002277:Carcinoma / Q000139:chemically induced; D002296:Carcinosarcoma / Q000139:chemically induced; D056486:Chemical and Drug Induced Liver Injury; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004700:Endocrine System Diseases / Q000139:chemically induced; D004732:Endrin / Q000633:toxicity*; D005260:Female; D005833:Genital Neoplasms, Female / Q000139:chemically induced; D006965:Hyperplasia / Q000139:chemically induced; D007674:Kidney Diseases / Q000139:chemically induced; D008113:Liver Neoplasms / Q000139:chemically induced; D008297:Male; D051379:Mice; D009135:Muscular Diseases / Q000139:chemically induced; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009393:Nephritis / Q000139:chemically induced; D010911:Pituitary Neoplasms / Q000139:chemically induced; D051381:Rats; D012737:Sex Factors; D013964:Thyroid Neoplasms / Q000139:chemically induced; D014594:Uterine Neoplasms / Q000139:chemically induced
D002273:Carcinogens; D004732:Endrin