Preliminary report on the clinical use of human leukocyte interferon in neuroblastoma.
The effectiveness of human leukocyte interferon (IF) injections on a female patient, 21 years old, with stage IV neuroblastoma was observed. IF (30 X 10(4) units) injected every second day intratumorally or around the tumor tissue rapidly reduced the tumor size. However, systemic administration of 300 x 10(4) units of IF by im injection showed no beneficial effects. Our results suggest that a high IF level in tumor tissue may be necessary to bring about tumor reduction.
D000328:Adult; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D007267:Injections; D007372:Interferons / Q000627:therapeutic use*; D007962:Leukocytes / Q000502:physiology; D009447:Neuroblastoma / Q000188:drug therapy*; D012075:Remission, Spontaneous
D007372:Interferons