title: [Absorption and hematologic effect of streptokinase-streptodornase (varidase) after intracavital or oral administration].
abstract: A series of patients who received intracavitary streptokinase/streptodornase after thoracotomy or laparotomy were compared with a control group. They showed a highly significant increase in plasma streptokinase tolerance, indicating absorption of the streptokinase from the cavity. Changes in blood coagulation, plasma cell count and immunoglobulins were not observed. In a series of patients with leg ulcers treated with streptokinase/streptodornase by mouth, no increase in plasma streptokinase tolerance was observed, indicating that orally administered streptokinase is not absorbed from the gastro-intestinal tract.
mesh_terms: D000005:Abdomen; D000042:Absorption; D000284:Administration, Oral; D000287:Administration, Topical; D000368:Aged; D000917:Antibody Formation; D001773:Blood Cells; D001798:Blood Proteins / Q000032:analysis; D004322:Drainage; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D007871:Leg Ulcer / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D013299:Streptodornase and Streptokinase / Q000008:administration & dosage* / Q000494:pharmacology; D013909:Thorax
chemical_list: D001798:Blood Proteins; D013299:Streptodornase and Streptokinase
vernacular_title: Absorption und hämatologische Wirkungen von intrakavitär und oral applizierter Streptokinase-Streptodornase (Varidase).