Secretion of "inhibin" by rat granulosa cells in vitro.
Rat granulosa cells secrete a substance in vitro that acts directly upon cultured rat pituitary cells to preferentially suppress FSH production. It is inferred from these results that the granulosa cell is a source of ovarian "inhibin" and that the pituitary gonadotroph is a site of "inhibin" action.
D000818:Animals; D002478:Cells, Cultured; D003470:Culture Media; D005260:Female; D005640:Follicle Stimulating Hormone / Q000037:antagonists & inhibitors / Q000378:metabolism*; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors*; D006107:Granulosa Cells / Q000378:metabolism*; D066298:In Vitro Techniques; D007986:Luteinizing Hormone / Q000378:metabolism; D010903:Pituitary Gland, Anterior / Q000187:drug effects / Q000378:metabolism; D010905:Pituitary Hormone Release Inhibiting Hormones / Q000037:antagonists & inhibitors*; D051381:Rats
D003470:Culture Media; D010905:Pituitary Hormone Release Inhibiting Hormones; D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone