Effect of proteinases on EA (IgG)-binding receptors of rat macrophages.
Pronase, trypsin and delta-chymotrypsin deplete rat alveolar peritoneal macrophages of EA (IgG)-binding activity. Trypsin and delta-chymotrypsin show an initially--under certain conditions and lasting--enhancement of receptor activity. Cycloheximide, an inhibitor of protein biosynthesis, accelerated the loss of Fc-receptors and inhibited their reappearance. There are differences between alveolar and peritoneal macrophages in the rate of loss as well as of regeneration of Fc-receptors.
D000818:Animals; D002918:Chymotrypsin / Q000494:pharmacology; D003513:Cycloheximide / Q000494:pharmacology; D010450:Endopeptidases / Q000494:pharmacology*; D004912:Erythrocytes / Q000276:immunology*; D007074:Immunoglobulin G; D008264:Macrophages / Q000276:immunology*; D008297:Male; D011402:Pronase / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D011961:Receptors, Fc / Q000187:drug effects; D014357:Trypsin / Q000494:pharmacology
D007074:Immunoglobulin G; D011961:Receptors, Fc; D003513:Cycloheximide; D010450:Endopeptidases; D002918:Chymotrypsin; D014357:Trypsin; D011402:Pronase