Effects of cortisone and thyroxine on intestinal trehalase activity in infant mouse.
Cortisone acetate (25 microgram/g b.wt/day) administration to 8-day-old suckling mice induces a premature increase of trehalase activity along the entire small intestine. On the other hand, thyroxine (1 microgram/g b.wt/day) in unable to provoke a precocious increase of trehalase activity. Trehalase appears to be the only brush border membrane disaccharidase controlled solely by glucocorticoid hormones during the postnatal maturation of the intestine.
D000818:Animals; D003348:Cortisone / Q000494:pharmacology*; D007421:Intestine, Small / Q000187:drug effects / Q000201:enzymology*; D051379:Mice; D013393:Sucrase / Q000378:metabolism; D013974:Thyroxine / Q000494:pharmacology*; D014198:Trehalase / Q000378:metabolism*; D000520:alpha-Glucosidases / Q000378:metabolism
D000520:alpha-Glucosidases; D014198:Trehalase; D013393:Sucrase; D013974:Thyroxine; D003348:Cortisone