title: Salt, diuretics and pregnancy.
abstract: This article reviews the homeostasis of water and salt in normal and pre-eclamptic pregnancy. During pre-eclampsia there is a decrease in circulating plasma volume, which the administration of diuretics reduces still further. There is no proof that diuretics have a beneficial effect on prevention or treatment of toxemia of pregnancy. They should thus be regarded as contraindicated, except in cases of cardiac insufficiency and certain renal diseases.
mesh_terms: D000450:Aldosterone / Q000378:metabolism; D000804:Angiotensin II / Q000502:physiology; D000818:Animals; D001581:Benzothiadiazines; D004232:Diuretics; D005260:Female; D005919:Glomerular Filtration Rate; D006706:Homeostasis; D006801:Humans; D010953:Plasma Volume; D011225:Pre-Eclampsia / Q000188:drug therapy / Q000378:metabolism*; D011247:Pregnancy; D012083:Renin / Q000502:physiology; D012965:Sodium Chloride / Q000172:deficiency / Q000378:metabolism*; D049993:Sodium Chloride Symporter Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D014882:Water-Electrolyte Balance
chemical_list: D001581:Benzothiadiazines; D004232:Diuretics; D049993:Sodium Chloride Symporter Inhibitors; D000804:Angiotensin II; D012965:Sodium Chloride; D000450:Aldosterone; D012083:Renin