A multicentre pilot study of parenteral and rectal administration of domperidone in the treatment of severe vomiting in children.
A small scale pilot study among 41 children with severe vomiting, showed that a single administration of domperidone either intravenously, intramuscularly or rectally, effectively controlled the symptom within 3 hours in 36 (88%) patients. The excellent results together with the safety of this new drug indicate its potential value in these patients.
D000293:Adolescent; D000932:Antiemetics / Q000008:administration & dosage / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D007223:Infant; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D008297:Male; D010865:Pilot Projects; D010880:Piperidines / Q000627:therapeutic use*; D012007:Rectum; D013997:Time Factors; D014839:Vomiting / Q000188:drug therapy*
D000932:Antiemetics; D001562:Benzimidazoles; D010880:Piperidines