title: Tooth staining effects of an alexidine mouthwash.
abstract: The primary purpose of this study was to determine the amount of tooth staining produced by an alexidine mouthrinse. One hundred and eighty subjects rinsed twice daily for 1 month with either 15 ml of alexidine (0.035%) or a placebo solution. Prior to the study, the subjects were classified according to their smoking, coffee and tea drinking habits and these factors were subsequently considered in the analysis of the stain scores. Additionally, the effects on staining of a prior prophylaxis and the use of a fluoridated toothpaste during the study were determined. Upon termination of the study, subjects utilizing the active mouthrinse manifested a greater degree of staining than placebo users. The amount and intensity of the stain due to alexidine were not influenced (increased) by smoking, tea or coffee drinking habits. A prior prophylaxis did not reduce the staining propensity of alexidine users. The method of scoring developed can be used to assess the degree of tooth staining induced by antiplaque agents.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001645:Biguanides / Q000009:adverse effects*; D002986:Clinical Trials as Topic; D003069:Coffee / Q000009:adverse effects; D003773:Dental Plaque / Q000517:prevention & control; D003777:Dental Prophylaxis; D004311:Double-Blind Method; D005260:Female; D005459:Fluorides / Q000494:pharmacology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009067:Mouthwashes / Q000009:adverse effects*; D010919:Placebos; D012907:Smoking / Q000150:complications; D013662:Tea / Q000009:adverse effects; D014075:Tooth Discoloration / Q000139:chemically induced* / Q000209:etiology; D014100:Toothpastes / Q000494:pharmacology
chemical_list: D001645:Biguanides; D003069:Coffee; D009067:Mouthwashes; D010919:Placebos; D013662:Tea; D014100:Toothpastes; D005459:Fluorides