The risk of streptococcal infections in rheumatic and non-rheumatic families: an application of Greenwood's chain-binomial model.
Infectious transmission of streptococci in families has been demonstrated to follow Greenwood's chain-binomial model in its simplest form which did not need beta transformation to correct for differences in susceptibility between families. Following the application of this model, an estimate of the risk of acquisition of M-typable group A beta-hemolytic streptococci is given (p = 0.05--0.06). The risk is the same among siblings of rheumatic fever patients and children from non-rheumatic families. This emphasizes that the familial aggregation associated with rheumatic fever is not due to increased susceptibility of such families to streptococcal infections.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D008962:Models, Theoretical; D011446:Prospective Studies; D012213:Rheumatic Fever / Q000209:etiology*; D012306:Risk; D013290:Streptococcal Infections / Q000150:complications* / Q000635:transmission; D013297:Streptococcus pyogenes