Attachment of polymorphonuclear leukocytes to glomeruli with immune deposits.
A method for quantitative evaluation of a biological activity of immune complexes deposited in glomeruli is described. The activity reflects the activation of complement and is represented by the number of PMN attached to a glomerulus. It is possible to compare data from different individuals or different phases of glomerulonephritis. The complement component concerned is considered to be C3, activated through the classical or alternate pathway.
D000818:Animals; D000936:Antigen-Antibody Complex; D002452:Cell Count; D003167:Complement Activation; D005455:Fluorescent Antibody Technique; D005921:Glomerulonephritis / Q000276:immunology*; D007678:Kidney Glomerulus / Q000276:immunology*; D009504:Neutrophils / Q000166:cytology / Q000276:immunology*; D051381:Rats
D000936:Antigen-Antibody Complex