RNA polymerase III transcriptional units are interspersed among human non-alpha-globin genes.
Cloned human DNA fragments containing globin genes are transcribed in vitro to form discrete RNA species. One transcription unit is located approximately 1500 base pairs upstream from the G-gamma-globin gene. This transcript is partially homologous to a polymerase III template located approximately 1000 base pairs upstream from the delta-globin gene and to DNA located a short distance downstream from the beta-globin gene.
D003001:Cloning, Molecular; D004274:DNA, Recombinant / Q000378:metabolism*; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism*; D004926:Escherichia coli / Q000378:metabolism; D005796:Genes; D005914:Globins / Q000096:biosynthesis*; D006367:HeLa Cells / Q000378:metabolism; D006801:Humans; D010957:Plasmids; D012320:RNA Polymerase III / Q000378:metabolism*; D014158:Transcription, Genetic
D004274:DNA, Recombinant; D005914:Globins; D012321:DNA-Directed RNA Polymerases; D012320:RNA Polymerase III