[Intercellular information transfer in the process of immunogenesis. VI. The induction of antiphage antibody synthesis in the cells of rat transplantable lymphosarcoma under the influence of splenic RNA from rats and mice immunized with phage T2].
It has been proved that nuclear and cytoplasmic RNAs, isolated from spleens of T2 phage immunized rats and mice, can induce T2 phage antibodies in cells of the transplantable rat lymphosarcoma. With the nuclear RNA from rat spleens, the effect is persisting in a number of subsequent cell generations. The data presented are principally in accord with results of the authors' previous studies in which lymphosarcoma cells were treated with RNA extracted from spleens of rat immunized with sheep red cells. These results well compare with the authors' earlier advanced hypothesis suggesting a possible involvement of RNA in deblockation of genes responsible for the synthesis of the antibodies in question.
D000818:Animals; D000912:Antibodies, Neoplasm / Q000096:biosynthesis; D000914:Antibodies, Viral / Q000096:biosynthesis*; D000917:Antibody Formation; D001433:Bacteriolysis; D003090:Coliphages / Q000276:immunology*; D004926:Escherichia coli; D007111:Immunity, Cellular; D007112:Immunity, Maternally-Acquired; D007114:Immunization; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology*; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000276:immunology; D012313:RNA / Q000276:immunology*; D051381:Rats; D013154:Spleen / Q000276:immunology*; D013997:Time Factors
D000912:Antibodies, Neoplasm; D000914:Antibodies, Viral; D012313:RNA
O mezhkletochnoĭ peredache informatsii v protsesse immunogeneza. VI. Induktsiia sinteza antifagovykh antitel v kletkakh perevivnoĭ limfosarkomy krys pod vliianiem RNK selezenki krys i mysheĭ, immunizirovannykh fagom T2.