[Has the calculation of the rate of tumor growth clinical significance?].
In 142 circular lung foci of 78 patients we determined the tumor doubling times (13 bronchial carcinomas, 7 benign pulmonary tumors, and 122 pulmonary metastases). They fluctuated between + 12 and + 8,863 days of tumor growth and a diminuation of -1,810 days of half-life. 44% of all pulmonary metastases doubled their volumes within 60 to 250 days. During the observation period the times of tumor growth varied not only in different pulmonary metastases of the same patient, but also in solitary circular lung foci of the same person considerably. There is no connexion between tumor doubling time and histological tumor type as well as the interval between surgery of the primary tumor and occurrence of pulmonary metastases. Though we found in patients of 10 to 30 years of age only quickly growing pulmonary metastases with a tumor doubling time of less than 60 days a corrlation between time of tumor growth and age could not be proved. By the determination of the tumor doubling time neither binding statements on the nature of a circular lung focus can be made nor clinical consequences for diagnostics or therapy be drawn.
D000293:Adolescent; D001984:Bronchial Neoplasms / Q000503:physiopathology; D002277:Carcinoma / Q000503:physiopathology; D002822:Choriocarcinoma / Q000503:physiopathology; D005260:Female; D005266:Femoral Neoplasms / Q000503:physiopathology; D006801:Humans; D008175:Lung Neoplasms / Q000503:physiopathology* / Q000556:secondary; D008297:Male; D008433:Mathematics; D008875:Middle Aged; D011247:Pregnancy; D013736:Testicular Neoplasms / Q000503:physiopathology; D013997:Time Factors; D014594:Uterine Neoplasms / Q000503:physiopathology
Hat die Berechnung der Geschwindigkeit des Geschwulstwachstums klinische Bedeutung?