title: [Bone diseases due to long-term administration of anticonvulsants during the age of growth].
abstract: On the basis of literature and 2 own observations a survey is given concerning the modern knowledge of bone changes as concomitant effect by long-term treatment with anticonvulsive drugs (diphenyl hydantoin and primidon) at the age of growth (osteopathia antiepileptica). The discussion of arising actual questions is demonstrated on instructive cases with consequences important for practice.
mesh_terms: D000293:Adolescent; D000328:Adult; D000469:Alkaline Phosphatase / Q000378:metabolism; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D002118:Calcium / Q000097:blood; D004827:Epilepsy / Q000188:drug therapy*; D005264:Femoral Fractures / Q000139:chemically induced; D005592:Fracture Fixation; D006801:Humans; D008297:Male; D010018:Osteomalacia / Q000139:chemically induced* / Q000601:surgery; D013977:Tibia / Q000601:surgery
chemical_list: D000927:Anticonvulsants; D000469:Alkaline Phosphatase; D002118:Calcium
vernacular_title: Osteopathien unter Dauermedikation mit Antikonvulsiva im Wachstumsalter.