title: Juvenile dermatitis herpetiformis.
abstract: Juvenile dermatitis herpetiformis occurred in a 20-month-old girl. She had granular lgA, C3, and fibrin bound to the basement membrane zone of the skin by direct immunofluorescence and negative serum antibodies against the skin on indirect immunofluorescence. The HLA typing of peripheral lymphocytes was A1, Aw30, B8, Bw51 without clinical evidence of malabsorption syndrome. A rapid improvement was observed on dapsone therapy. These findings strongly suggest that juvenile dermatitis hepetiformis is a disease entity different from chronic bullous dermatosis of childhood.
mesh_terms: D001485:Basement Membrane / Q000276:immunology / Q000378:metabolism; D003176:Complement C3 / Q000032:analysis; D003874:Dermatitis Herpetiformis / Q000276:immunology* / Q000378:metabolism; D005260:Female; D005337:Fibrin / Q000378:metabolism; D005455:Fluorescent Antibody Technique; D006680:HLA Antigens / Q000032:analysis*; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007223:Infant; D010641:Phenotype; D012867:Skin / Q000276:immunology
chemical_list: D003176:Complement C3; D006680:HLA Antigens; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D005337:Fibrin