title: [Glomerulopathy during Behçet's syndrome. Immunofluorescent and electron microscopy studies (author's transl)].
abstract: Full renal investigation were conducted in 11 patients with Behçet's syndrome. Biological tests revealed the presence of mild proteinuria in 5 of them. Needle biopsy showed extra-membranous or mesangial fibrinoid deposits in 6 cases, associated in 1 case with segmental and focal glomerulitis lesions. Immunofluorescence studies demonstrated glomerular deposits of mesangial and extra-membranous C3, sometimes with immunoglobulins (IgA-AgG). Ultrastructural examination was carried out in 7 cases and showed "hump" deposits attached to the external face of the basal membrane and rounded nodules of 7 to 15 mu included in the mesangium. The presence of immune complexes in the renal glomeruli, therefore, is not all unusual in this disease, which is probably auto-immune in nature, and in fact appears to be a quite frequent occurrence. These deposits, which were probably well-tolerated by most of the patients in this series, might be involved in the production of progressive glomerulopathies in chronic cases, as observed in one of the cases studied.
mesh_terms: D000293:Adolescent; D000328:Adult; D000936:Antigen-Antibody Complex; D001528:Behcet Syndrome / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D005455:Fluorescent Antibody Technique; D005921:Glomerulonephritis / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007678:Kidney Glomerulus / Q000276:immunology / Q000473:pathology / Q000648:ultrastructure*; D008297:Male; D011507:Proteinuria / Q000209:etiology
chemical_list: D000936:Antigen-Antibody Complex
vernacular_title: Glomérulopathies du syndrome de Behçet. Etude en immunofluorescence et microscopie électronique.