The effect of dietary amino acids on immune reactivity.
The plaque-forming cell response and serum antibody titres to sheep red blood cells (SRBC) were enhanced in mice fed diets moderately deficient in the amino acids phenylalanine-tyrosine. These diets sustained normal growth during a 4 week study period. More severe limitation of phenylalanine-tyrosine or multiple essential amino acid restriction gave rise to a slight increas in the delayed hypersensitivity reaction to SRBC. These latter diets usually limit growth; nevertheless the humoral immune response to SRBC was not significantly depressed except in the mice fed a diet (diet 7) with severe restriction of seven essential amino acids. These results suggest that dietary restriction may suppress the production or function of an inhibitory cell, such as a suppressor T cell, whilst not affecting the effector cell to the same degree.
D000596:Amino Acids / Q000172:deficiency*; D000601:Amino Acids, Essential / Q000172:deficiency; D000818:Animals; D000906:Antibodies / Q000032:analysis; D000917:Antibody Formation; D004032:Diet; D006462:Hemolytic Plaque Technique; D006968:Hypersensitivity, Delayed; D007111:Immunity, Cellular; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009929:Organ Size; D010649:Phenylalanine / Q000172:deficiency; D013154:Spleen / Q000033:anatomy & histology; D014443:Tyrosine / Q000172:deficiency
D000596:Amino Acids; D000601:Amino Acids, Essential; D000906:Antibodies; D014443:Tyrosine; D010649:Phenylalanine