[An introduction to synthetic progestogens pharmacology (author's transl)].
Synthetic progestins differ in their progestomimetic and other endocrine effects. Their affinities for different steroid hormone receptors have been measured and their pharmacological activities (progestomimetic, uterotrophic, anti-estrogenic, androgen and anti-gonadotrophic) have been evaluated concomitantly. Derivatives of the pregnane series are basically progestomimetic only, whereas derivatives of the norandrostane series have distinctly androgenic and anti-estrogenic properties. A knowledge of these various activities facilitates the choice of an appropriate therapy.
D000726:Androgen Antagonists / Q000494:pharmacology; D000818:Animals; D002369:Castration; D003600:Cytosol / Q000378:metabolism; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D007700:Kinetics; D008297:Male; D051379:Mice; D045167:Progesterone Congeners / Q000494:pharmacology; D011467:Prostate / Q000187:drug effects / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D011960:Receptors, Estrogen / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000187:drug effects / Q000378:metabolism*; D013329:Structure-Activity Relationship; D014018:Tissue Distribution; D014599:Uterus / Q000187:drug effects / Q000378:metabolism
D000726:Androgen Antagonists; D045167:Progesterone Congeners; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D004958:Estradiol
Introduction â la pharmacologie des progestatifs de synthése.