Inhibition of spermatogenesis in the rat by treatment with [D-Ala6, Des-Gly-NH210] LHRH ethylamide.
The effect of treatment with a potent LHRH agonist, [D-Ala6, Des-Gly-NH210]LHRH ethylamide, injected at the low dose of 100 ng, twice a week, was evaluated on spermatogenesis in the rat. Significant degenerative changes of seminiferous tubules could be observed after two weeks of treatment. These changes were progressive and led to a marked inhibition of spermatogenesis after four to eight weeks of treatment. Testis weight was decreased to approximately 50% of control after eight weeks of treatment.
D000818:Animals; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology; D006728:Hormones / Q000494:pharmacology; D007985:Leydig Cells / Q000187:drug effects / Q000502:physiology; D008297:Male; D051381:Rats; D012671:Seminiferous Tubules / Q000187:drug effects / Q000502:physiology; D013091:Spermatogenesis / Q000187:drug effects*
D006728:Hormones; D007987:Gonadotropin-Releasing Hormone