Beneficial actions of prostacyclin in traumatic shock.
Prostacyclin (PGI2) infused at a rate of 350 ng/kg/min significantly increased survival time in rats subjected to Noble-Collip drug trauma from 2.7 +/- 0.3 to 4.6 +/- 0.2 h (p less than 0.01) compared with traumatized rats given only the vehicle (Tris buffer). Moreover, PGI2 treated rats exhibited significantly lower circulating cathepsin D and myocardial depressant factor (MDF) activities, indicative of lower lysosomal disruption and lower toxic factor formation. PGI2 induced vasodilation in rats as well as these other protective effects.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002403:Cathepsins / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D011464:Epoprostenol / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D008954:Models, Biological; D009201:Myocardial Depressant Factor / Q000378:metabolism; D011453:Prostaglandins / Q000627:therapeutic use*; D051381:Rats; D012774:Shock, Traumatic / Q000188:drug therapy* / Q000401:mortality
D009201:Myocardial Depressant Factor; D011453:Prostaglandins; D011464:Epoprostenol; D002403:Cathepsins