title: Transmission of allosteric effects in DNA.
abstract: Binding of distamycin induces a cooperative transition of calf thymus DNA to a new form with higher affinity for the drug and altered structural properties.
mesh_terms: D000494:Allosteric Regulation; D000818:Animals; D001665:Binding Sites; D002417:Cattle; D002942:Circular Dichroism; D004247:DNA; D004269:DNA, Bacterial; D004214:Distamycins / Q000494:pharmacology*; D004926:Escherichia coli; D004996:Ethidium / Q000378:metabolism; D007700:Kinetics; D008970:Molecular Weight; D009690:Nucleic Acid Conformation / Q000187:drug effects; D011758:Pyrroles / Q000494:pharmacology*; D013950:Thymus Gland
chemical_list: D004269:DNA, Bacterial; D004214:Distamycins; D011758:Pyrroles; D004247:DNA; D004996:Ethidium