The effect of azathioprine, hydrocortisone and trimethazone on the occurrence of active lymphocytes in liver of endotoxin treated rabbits.
After the administration of azathioprine, hydrocortisone and trimethazone to endotoxin-treated rabbits, the percentage of active lymphocytes (determined by means of the nucleolar test) decreased in the liver, while the lymphocytes in the peripheral blood were not affected. The assumption that in endotoxemia the liver may be a target organ for active lymphocytes and that autoimmune processes may participate in liver damage is discussed.
D000284:Administration, Oral; D000818:Animals; D001323:Autoantibodies / Q000276:immunology; D001379:Azathioprine / Q000494:pharmacology*; D004731:Endotoxins; D004926:Escherichia coli; D005260:Female; D006854:Hydrocortisone / Q000494:pharmacology*; D007273:Injections, Intramuscular; D008099:Liver / Q000276:immunology* / Q000502:physiology; D008214:Lymphocytes / Q000187:drug effects*; D010653:Phenylbutazone / Q000031:analogs & derivatives* / Q000494:pharmacology*; D011720:Pyrazoles / Q000494:pharmacology*; D011817:Rabbits
D001323:Autoantibodies; D004731:Endotoxins; D011720:Pyrazoles; C100215:tribuzone; D010653:Phenylbutazone; D001379:Azathioprine; D006854:Hydrocortisone