Analysis of anaphase in cell culture: an adequate test system for the distinction between compounds which selectively alter the chromosome structure or the mitotic apparatus.
A system of anaphase analysis is presented as an adequate test to detect aberrations in chromosome structure and alterations in the mitotic apparatus. Particular emphasis is placed on those data which suggest that proteins may be the preferred targets of chemical compounds that induce aneuploidy.
D000705:Anaphase / Q000187:drug effects*; D000818:Animals; D002453:Cell Cycle / Q000187:drug effects*; D002460:Cell Line; D002869:Chromosome Aberrations; D006224:Cricetinae; D003412:Cricetulus; D004353:Drug Evaluation, Preclinical; D005260:Female; D005821:Genetic Techniques; D008938:Mitosis / Q000187:drug effects; D008940:Mitotic Index; D009153:Mutagens; D010053:Ovary / Q000473:pathology
D009153:Mutagens