A double-blind comparison of domperidone and metoclopramide suppositories in the treatment of nausea and vomiting in children.
In a double-blind trial in 60 children suffering from gastroenteritis complicated by vomiting, it was found that suppositories of domperidone (30 mg) were more effective than either metoclopramide (10 mg) or placebo in reducing the severity of vomiting, nausea and other symptomatic parameters. No side effects were reported throughout the 24 hour period of the trial and the results suggest that domperidone suppositories may well prove to be the drug of choice in such cases of paediatric vomiting.
D000932:Antiemetics / Q000008:administration & dosage / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D005759:Gastroenteritis / Q000150:complications; D006801:Humans; D008297:Male; D008787:Metoclopramide / Q000627:therapeutic use*; D009325:Nausea / Q000188:drug therapy*; D010880:Piperidines / Q000627:therapeutic use*; D013488:Suppositories; D014839:Vomiting / Q000188:drug therapy*
D000932:Antiemetics; D001562:Benzimidazoles; D010880:Piperidines; D013488:Suppositories; D008787:Metoclopramide