Cellular immunity in asbestosis.
A highly statistically significant correlation was found between asbestosis and impaired responsiveness in skin reaction to intermediate and second strength tuberculin and SK-SD. Considering ANA incidence these antibodies were found with higher frequency in asbestos workers who lacked a cutaneous response to the recall antigens. In asbestosis cases peripheral blood lymphocyte profiles are also abnormal demonstrating low proportions of E-RFC. Moreover, MIF test results showed the impairment of this cytokine generation when lymphocytes were stimulated with SK-SD, PPD and PHA in asbestosis cases. The lymphocyte transformation study documents an impaired response mainly to a lower dose of PHA and ConA in asbestosis cases and in asbestos workers with ANA.
D000974:Antibodies, Antinuclear / Q000032:analysis; D001195:Asbestosis / Q000276:immunology*; D002464:Cell Migration Inhibition; D006801:Humans; D007111:Immunity, Cellular; D037102:Lectins / Q000494:pharmacology; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D008263:Macrophage Migration-Inhibitory Factors / Q000096:biosynthesis; D012397:Rosette Formation; D012882:Skin Tests
D000974:Antibodies, Antinuclear; D037102:Lectins; D008263:Macrophage Migration-Inhibitory Factors