title: [Determination of plasmatic C-peptide and its clinical uses].
abstract: Physiopathological basis and methodological implications of the radioimmunological estimation of plasma C-peptide, as a test of beta cell secretory activity, are reviewed. Personal results are reported concerning C-peptide assay, both in basal and stimulative conditions, in insulindependent long-and short-term diabetes. In 1 case of organic, and 2 cases of functional hyperinsulinism, the test gave useful clinical information. The method of L. Heding-Novo Research Institute, Bagsvaerd, Denmark-, with previous elimination of proinsulin and insulinantibody in patients with high values of IgG insulin binding, proved to be suitable to endocrinological routine.
mesh_terms: D002096:C-Peptide / Q000032:analysis / Q000097:blood*; D003920:Diabetes Mellitus / Q000175:diagnosis / Q000503:physiopathology*; D006801:Humans; D006946:Hyperinsulinism / Q000503:physiopathology*; D007328:Insulin / Q000378:metabolism*; D007330:Insulin Antibodies / Q000302:isolation & purification; D007333:Insulin Resistance; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000502:physiology* / Q000503:physiopathology; D010186:Pancreatic Function Tests; D010455:Peptides / Q000097:blood*; D011863:Radioimmunoassay
chemical_list: D002096:C-Peptide; D007328:Insulin; D007330:Insulin Antibodies; D010455:Peptides
vernacular_title: Determinazione del C-peptide plasmatico e sue applicazioni cliniche.