Identification and processing of proglucagon in pancreatic islets.
Immunoprecipitation and tryptic peptide analysis of newly synthesized proteins from rat islets have identified an 18,000 molecular weight (MW) protein as proglucagon. Conversion of this precursor was kinetically similar to the conversion of proinsulin and resulted in the formation of both pancreatic glucagon and a 10,000-MW protein lacking this hormonal sequence.
D000818:Animals; D005934:Glucagon / Q000096:biosynthesis* / Q000276:immunology; D007515:Islets of Langerhans / Q000378:metabolism*; D007700:Kinetics; D008970:Molecular Weight; D010446:Peptide Fragments / Q000378:metabolism; D011498:Protein Precursors / Q000276:immunology / Q000378:metabolism*; D051381:Rats
D010446:Peptide Fragments; D011498:Protein Precursors; D005934:Glucagon