title: [Synopsis of psychopathological, electroencephalographical, and pharmacokinetic variables during antidepressive treatment with viloxazine (author's transl)].
abstract: In order to achieve a more differentiated assessment of the profile and time course of treatment with a new antidepressant drug, several psychiatric, neurophysiological, and biochemical parameters were examined in a double-blind study (viloxazine versus amitriptyline). Special attention was directed to the use of a time-blind audiovisual technique. The TV technique allowed to demonstrate an earlier onset of the therapeutic effect under viloxazine, which is in good agreement with the cross-sectional and longitudinal profile of viloxazine as regards pharmacokinetics and EEG.
mesh_terms: D000639:Amitriptyline / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003863:Depression / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D004311:Double-Blind Method; D004569:Electroencephalography; D006801:Humans; D007700:Kinetics; D009025:Morpholines / Q000627:therapeutic use*; D013997:Time Factors; D014743:Videotape Recording; D014745:Viloxazine / Q000378:metabolism / Q000627:therapeutic use*
chemical_list: D009025:Morpholines; D000639:Amitriptyline; D014745:Viloxazine
vernacular_title: Synopsis psychopathologischer, elektroenzephalographischer und pharmakokinetischer Parameter unter einer antidepressiven Therapie mit Viloxazin.