Immunochemical studies on free lipid A from Proteus mirabilis 1959.
The chemical composition and serological activity of free lipid A from Proteus were studied. Only two fatty acids: myristic acid and 3-hydroxymyristic acid were detected. When calculated for glucosamine disaccharide unit, 2 moles of ester-linked and 1 mole of amide-linked fatty acid are present. Amino group of glucosaminyl residue is substituted by 3-hydroxymyristic acid. The occurence of an uncommon (4-aminoarabinose) substituent, attached outside the backbone, was noticed. The results of serological investigation indicate the great similarity between antigenic determinants of Proteus lipid A and Salmonella-type of lipid.
D000942:Antigens, Bacterial / Q000032:analysis*; D003429:Cross Reactions; D005227:Fatty Acids / Q000032:analysis; D007115:Immunization Schedule; D008050:Lipid A / Q000032:analysis / Q000276:immunology*; D008070:Lipopolysaccharides / Q000276:immunology*; D011513:Proteus mirabilis / Q000276:immunology*; D013045:Species Specificity
D000942:Antigens, Bacterial; D005227:Fatty Acids; D008050:Lipid A; D008070:Lipopolysaccharides