Dextranomer: a review of its general properties and therapeutic efficacy.
Dextranomer is a hydrophilic dextran polymer advocated as a 'cleansing agent' for various types of exudating wounds or ulcers, including stasis (venous) ulcers and decubitus ulcers. It appears to exert its effect by a capillary action which absorbs wound exudate, as well as wound debris and micro-organisms, into the dextranomer beads or into the spaces between the beads, thus removing such products from the wound surface. Dextranomer is an aid to wound or ulcer management, and does not directly affect tissue repair in such ulcers, but as with other 'cleansing' agents or techniques, removal of debris (and possibly micro-organisms) from the wound could be expected to promote natural healing. Reports of its effectiveness in open studies, often in patients with seemingly resistant lesions, have been encouraging. Similarly, in comparative trials results have usually favoured dextranomer, but a clear indication of the relative efficacy and benefits as compared with other treatments used for exudating lesions has not yet emerged. Further well designed comparative studies are needed to provide such information.
D000818:Animals; D002056:Burns / Q000188:drug therapy; D002845:Chromatography; D003911:Dextrans / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D005122:Exudates and Transudates / Q000378:metabolism; D006801:Humans; D007871:Leg Ulcer / Q000188:drug therapy; D003668:Pressure Ulcer / Q000188:drug therapy; D014945:Wound Healing / Q000187:drug effects
D003911:Dextrans