title: Clinical trial of Debrisan in superficial ulceration.
abstract: A total of thirty cases of sacral ana leg uleration, burns, and infected sinuses were treated with Debrisan in glycerine (4/1 v/v), after removal of adherent necrotic tissue surgically. The preparation was effective in cleansing the wound, in most cases reducing the bacterial colonization, and lessening the local inflammation and oedema. Production of healthy granulation tissue resulted and the lesions healed faster than expected. One-third of the lesions failed to respond to treatment, and the reasons for this are discussed. With some patient selection, this preparation proved to be valuable in the treatment of superficial ulcers and surgical wounds, in those lesions with sufficient exudate to enable Debrisan to act.
mesh_terms: D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000517:prevention & control; D001458:Bandages; D002056:Burns / Q000628:therapy; D002986:Clinical Trials as Topic; D003911:Dextrans / Q000008:administration & dosage* / Q000627:therapeutic use; D004811:Epichlorohydrin / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D005990:Glycerol; D006801:Humans; D007871:Leg Ulcer / Q000382:microbiology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D003668:Pressure Ulcer / Q000628:therapy; D012445:Sacrococcygeal Region; D012883:Skin Ulcer / Q000382:microbiology / Q000628:therapy*; D014946:Wound Infection / Q000628:therapy
chemical_list: D003911:Dextrans; D004811:Epichlorohydrin; D005990:Glycerol