title: [Bactericidal kinetics of cefazolin, cefoxitin and amikacin alone and in combination (author's transl)].
abstract: The in vitro activity of cefazolin, cefoxitin und amikacin alone and in combination was determined via membrane filtration against E. coli (n = 2), K. pneumoniae (n = 2) and of cefoxitin and amikacin against Proteus vulgaris (n = 1). Therapeutically achievable concentrations of cefazolin (10 micrograms/ml), cefoxitin (10 micrograms/ml) and amikacin (10 micrograms/ml) lead to a rapid bactericidal effect against all of our strains. The combination of cefazolin (10 micrograms/ml) and amikactin (5 micrograms/ml) and cefoxitin (10 micrograms/ml and amikacin (5 micrograms/ml) was synergistic against only one of the 2 K. pneumoniae strains. Cefoxitin and amikacin were antagonistic against the P. vulgaris strain but synergistic against both E. coli strains.
mesh_terms: D000583:Amikacin / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D001424:Bacterial Infections / Q000382:microbiology; D002437:Cefazolin / Q000494:pharmacology*; D002440:Cefoxitin / Q000494:pharmacology*; D002511:Cephalosporins / Q000494:pharmacology*; D004357:Drug Synergism; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D007612:Kanamycin / Q000031:analogs & derivatives*; D007711:Klebsiella pneumoniae / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011514:Proteus vulgaris / Q000187:drug effects; D013997:Time Factors
chemical_list: D002511:Cephalosporins; D007612:Kanamycin; D002440:Cefoxitin; D000583:Amikacin; D002437:Cefazolin
vernacular_title: Kinetik der Bakterizidie von Cefazolin, Cefoxitin und Amikacin allein und in Kombination.