Resistance of transplantation tolerance to X-irradiation.
With regard to the previous finding that suppressor cells participating in the state of transplantation tolerance were radiosensitive, the possibility was investigated whether tolerance can be abolished by irradiation. In the rat model used (AVN recipients, Lewis donors), both neonatally induced tolerance and tolerance induced in adult life by the transfer of suppressor cells were found to be radioresistant.
D000375:Aging; D000818:Animals; D000831:Animals, Newborn / Q000276:immunology; D006084:Graft Rejection / Q000528:radiation effects*; D007108:Immune Tolerance / Q000528:radiation effects*; D051381:Rats; D016038:Skin Transplantation; D013601:T-Lymphocytes / Q000276:immunology / Q000528:radiation effects / Q000637:transplantation; D014184:Transplantation, Homologous