Effect of diclofenac and naproxen on gastroduodenal mucosa.
The increases in medan scoresfluence on gastroduodenal mucosa of naproxen, 500 mg/day, and diclofenac, 100 mg/day, for 1 wk was investigated in 14 subjects in a double-blind randomized crossover study. Endoscopic examination of the gastroduodenal mucosa was carried out before and after each drug with regard to gastritis and hemorrhagic and erosive lesions. A 20-cm visual analogue scale was used for grading severity of mucosal changes. Naproxen caused statistically significant increases inmedian scores for all 3 variables, and 10 subjects showed a score increase in at least 1 variable; reaction to diclofenac occurred in only 4 subjects and the changes in median scores were not significant.
D000328:Adult; D002986:Clinical Trials as Topic; D004008:Diclofenac / Q000009:adverse effects*; D004311:Double-Blind Method; D004386:Duodenum / Q000473:pathology*; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D005756:Gastritis / Q000139:chemically induced / Q000473:pathology; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced / Q000473:pathology; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000473:pathology; D008297:Male; D009288:Naproxen / Q000009:adverse effects*; D010648:Phenylacetates / Q000009:adverse effects*; D010919:Placebos
D010648:Phenylacetates; D010919:Placebos; D004008:Diclofenac; D009288:Naproxen