Immunofluorescence studies in transient acantholytic dermatosis (Grover's disease).
Abnormalities were found by immunofluorescence in five of 11 (45%) patients with transient acantholytic dermatosis. There was no consistent pattern to the abnormalities; for example, they were circulating antibodies to intercellular and basal cell antigens in a third. Deposits of Ig and/or C3 were present in lesions of three patients and C3 was present in the intercellular substance in the lesions of a fourth patient. These findings suggest that different immune mechanisms may be involved in the pathogenesis of transient acantholytic dermatosis.
D000051:Acantholysis / Q000276:immunology* / Q000473:pathology; D003176:Complement C3 / Q000276:immunology; D005455:Fluorescent Antibody Technique; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D012871:Skin Diseases / Q000276:immunology*
D003176:Complement C3; D007074:Immunoglobulin G; D007075:Immunoglobulin M