Ames test of 1-(X-phenyl)-3,3-dialkyltriazenes. A quantitative structure-activity study.
The mutagenicity of 1-(X-phenyl)-3,3-dialkyltriazenes was tested in the Ames test using Salmonella typhimurium TA92. The following quantitative structure-activity relationship (QSAR) was formulated: log 1/C = 1.09 log P -1.63 sigma+ + 5.58. In this expression, C is the molar concentration of triazene producing 30 mutations/10(8) bacteria above background. This equation is based on 17 congeners and has a correlation coefficient of 0.974. The QSAR for mutagenicity is compared with QSAR for antileukemia action and toxicity (LD50) in mice. The mutagenicity of aflatoxin B (log 1/C = 9.5) and DTIC (log 1/C = 3.0) have also been determined.
D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity; D001711:Biotransformation; D002273:Carcinogens; D005260:Female; D066298:In Vitro Techniques; D007939:Leukemia L1210 / Q000188:drug therapy; D051379:Mice; D008862:Microsomes, Liver / Q000378:metabolism; D008954:Models, Biological; D009153:Mutagens; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D013329:Structure-Activity Relationship; D014226:Triazenes / Q000378:metabolism / Q000494:pharmacology / Q000633:toxicity*
D000970:Antineoplastic Agents; D002273:Carcinogens; D009153:Mutagens; D014226:Triazenes