title: [Pilocarpin eye drops with a novel Pilocarpin polymeric salt (author's transl)].
abstract: A new pilocarpin salt was obtained by chemically linking pilocarpin to a polymere substance. By galenic processing to the respective emulsion, eye drops containing this pilocarpin salt were produced, which enable a retarded pilocarpin delivery in vitro. With respect to glaucoma therapy, clinical tests showed that frequency of application can considerably be reduced. In the present investigations on a collective of 30 normal volunteers the effect of a commercial aqueous pilocarpin solution on the IOP, pupillary diameter and accommodation was compared with that of the novel pilocarpin drops.
mesh_terms: D000328:Adult; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D005901:Glaucoma / Q000188:drug therapy; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D009883:Ophthalmic Solutions; D010862:Pilocarpine / Q000494:pharmacology* / Q000627:therapeutic use; D011108:Polymers; D012996:Solutions; D014867:Water
chemical_list: D009883:Ophthalmic Solutions; D011108:Polymers; D012996:Solutions; D010862:Pilocarpine; D014867:Water
vernacular_title: Pilocarpin-Augentropfen mit einem neuartigen Pilocarpin-Polymersalz.