title: Estimation of haplotype frequency and linkage disequilibrium parameter in the HLA system.
abstract: Conventional formulae currently employed were extended to calculate the haplotype frequency and the corresponding variance for an arbitrary number (n) of loci when unrelated individuals were investigated. A formula is presented for the variance for the degree of three locus linkage disequilibrium.
mesh_terms: D002874:Chromosome Mapping; D003201:Computers; D005787:Gene Frequency; D008040:Genetic Linkage; D005821:Genetic Techniques; D006680:HLA Antigens; D006801:Humans
chemical_list: D006680:HLA Antigens