[Antibacterial effect of Ankerplast Spray].
The diffusion test yielded no satisfactory results. In the tube test, both the spray and the solvent (in a dilution of 1:4 and 1:8, respectively) proved to be bacteriostatically active against enterococci, Staphylococcus aureus, Escheria coli, Proteus, and Pseudomonas aeruginosa. These germs were killed within 30 minutes in the test for bactericidal activity, whereas the reference substance (1% phenol) required 1--2 hours, except against the last-named germ. Even the copolymer exerted a bactericidal effect, it is true, but only within 8 or 24 hours. The following results were obtained from the spray test with agar plate cultures: Streptococcus viridans species, streptococci, Diplococcus pneumoniae, Escheria coli, and Proteus were killed, whereas others survived under the plastic film for up to 9 days. Klebsiella and Pseudomonas aeruginosa had grown through the film within 7 days. In vivo experiments demonstrated a very potent antibacterial activity on the skin under the spray film.
D000085:Acetates / Q000494:pharmacology; D000179:Acrylates / Q000494:pharmacology*; D000336:Aerosols; D001419:Bacteria / Q000187:drug effects*; D002986:Clinical Trials as Topic; D004338:Drug Combinations; D004341:Drug Evaluation; D006801:Humans; D008689:Methacrylates / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests / Q000379:methods; D009779:Occlusive Dressings; D012867:Skin / Q000382:microbiology; D013997:Time Factors
D000085:Acetates; D000179:Acrylates; D000336:Aerosols; D004338:Drug Combinations; D008689:Methacrylates
Uber die antibakterielle Wirkung von Ankerplast-Spray.