title: The effect of tetracycline and/or scaling on human periodontal disease.
abstract: The objective of this study was to test the efficacy of scaling and root planing with or without adjunctive tetracycline therapy in the treatment of periodonitis in humans. The presence of plaque, gingival inflammation, probing depths and attachment levels was assessed for all teeth in 12 patients with chronic, advanced periodontitis. After an initial examination all patients were given detailed oral hygiene instructions. The teeth in one-half of each arch were then scaled and root planed. The teeth in the contralateral half were not treated. Six patients were given tetracycline (1 gm/day) during the first and second weeks and the seventh and eighth weeks of the trial. The study thus included four different treatment groups: 1) no treatment, 2) scaling and root planing alone, 3) tetracycline administration alone, and 4) scaling and root planing combined with tetracycline administration. All patients were reexamined at 8 and 25 weeks subsequent to the initiation of therapy. Both PlI and GI scores decreased significantly in all groups. The GI scores were significantly lower in the scaled and root planed areas as compared to the contralateral sides at both the 8- and 25-week examinations. The PlI score was lower in the scaled and root planed areas only at the 25-week interval. The gingival probing depths were reduced in all groups. A significantly greater decrease in probing depth, however, was noted in scaled and root planed areas. There was a trend to gain of attachment in the treated areas but the magnitude of the gain was very small. The findings of the trail also revealed that the administration of tetracycline had only a minor effect on the parameters examined.
mesh_terms: D000328:Adult; D002986:Clinical Trials as Topic; D003773:Dental Plaque; D003777:Dental Prophylaxis; D012534:Dental Scaling; D005260:Female; D006801:Humans; D008297:Male; D009910:Oral Hygiene; D010512:Periodontal Index; D010518:Periodontitis / Q000188:drug therapy / Q000628:therapy*; D012390:Root Canal Therapy; D013752:Tetracycline / Q000627:therapeutic use*
chemical_list: D013752:Tetracycline