Comparison of one daily injection of NPH and crystalline PZI insulins on urinary glucose in diabetic children.
Two one-injection insulin regimens--a combination of intermediate-action NPH insulin with regular insulin and a combination of long-acting PZI insulin with regular insulin, all of porcine origin and manufactured by Nordisk Insulin Laboratories--were compared to a group of 10 juvenile diabetics, each child serving as his own control. The results of thrice daily urine tests were recorded for periods of 3 months during each regimen and the incidence of glucosuria of less than 1% constituted the index used for metabolic control. Although the total insulin dose was almost the same with both schemes, it was found that less glucose was excreted during the night and early morning with the PZI regimen than the NPH regimen, indicating that a single injection of NPH is insufficient for good diabetic control.
D000293:Adolescent; D002648:Child; D002986:Clinical Trials as Topic; D003460:Crystallization; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D006029:Glycosuria; D006801:Humans; D007267:Injections; D007328:Insulin / Q000008:administration & dosage*; D049528:Insulin, Long-Acting / Q000008:administration & dosage* / Q000378:metabolism; D010179:Pancreas / Q000378:metabolism
D007328:Insulin; D049528:Insulin, Long-Acting