Chronic autoimmune neutropenia due to anti-NA1 antibody.
A 12-month-old child neutropenic since the age of 8 months, was referred to our institute for a sepsis from Candida albicans. On exploring the cause of neutropenia, an anti-NA1 antibody could be detected in the patient's serum. This antibody seemed to be responsible for the neutropenia because the child's PMN type was NA1+. The reactivity of the autoantibody with the patient's own granulocytes was confirmed by direct and indirect immunofluorescence studies performed on blood and marrow cells. A reduced number of T lymphocytes with poor PHA responsivity has been interpreted as the possible cause of the autoimmune disease. Steroid therapy did not cure the neutropenia but the child's general condition improved.
D000380:Agranulocytosis / Q000276:immunology*; D001323:Autoantibodies; D001327:Autoimmune Diseases / Q000150:complications*; D001789:Blood Group Antigens; D001853:Bone Marrow / Q000473:pathology; D002908:Chronic Disease; D005260:Female; D005455:Fluorescent Antibody Technique; D006098:Granulocytes / Q000276:immunology; D006801:Humans; D007223:Infant; D008213:Lymphocyte Activation; D009503:Neutropenia / Q000150:complications / Q000209:etiology / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D001323:Autoantibodies; D001789:Blood Group Antigens