Testicular cultivation of Treponema pallidum (Nichols strains) facilitated by sustained-release steroid administration.
Treponema pallidum cultivation is facilitated by substitution of methylprednisolone acetate suspension for hydrocortisone administration during rabbit testicular infection. Methylprednisolone suspension reduces testicular mononuclear cell infiltration and should benefit future studies of virulent T. pallidum.
D000818:Animals; D001431:Bacteriological Techniques; D006854:Hydrocortisone / Q000494:pharmacology; D008297:Male; D008775:Methylprednisolone / Q000494:pharmacology*; D011817:Rabbits; D013587:Syphilis / Q000382:microbiology*; D013737:Testis / Q000382:microbiology*; D014210:Treponema pallidum / Q000187:drug effects / Q000254:growth & development*
D006854:Hydrocortisone; D008775:Methylprednisolone