[State of several rat hematopoietic organs following total and subtotal irradiation and after bone marrow autotransplantation].
Hemopoiesis was studied in rats after x-ray irradiation. Lethal doses of 800--820 R were applied totally, with screening the shin and with subsequent autotransplantation of bone marrow taken from noninjured hemopoietic tissue. Survival of the animals and status of hemopoietic organs (quantitative indices of the peripheral blood, bone marrow and the spleen, as well as morphological changes in hemopoietic organs) served as tests. All totally irradiated animals died by the 20th day, the 30th day in the group of screened animals 32% survived, in the group with autotransplantation of bone marrow--62%. According to the indices studied restoration of hemopoiesis proceeded more quickly and completely in the group with autotransplantation of bone marrow and somewhat slower in the group with screening the shin (but without autotransplantation); this was accompanied by repopulation of bone marrow comparing with the totally irradiated animals. Restoration of the hemopoietic organs was followed by a comparatively rapid increase in the number of myeloid cells, while the number of lymphoid cells increased more slowly.
D000818:Animals; D001772:Blood Cell Count; D001853:Bone Marrow / Q000528:radiation effects; D016026:Bone Marrow Transplantation; D002452:Cell Count; D006410:Hematopoiesis / Q000528:radiation effects*; D011833:Radiation Injuries, Experimental / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D051381:Rats; D013154:Spleen / Q000528:radiation effects; D013997:Time Factors; D014182:Transplantation, Autologous; D014965:X-Rays
Sostoianie nekotorykh organov krovetvoreniia krys pri total'nom i subtotal'nom obluchenii i pri autotransplantatsii kostnogo mozga.