title: Skin necrosis after warfarin therapy.
abstract: A rare but potentially lethal complication of coumarin and its congeners is skin necrosis. A case of skin necrosis due to warfarin is reported and the literature is reviewed. It is suggested that if necrosis develops, the coumarin therapy should be terminated, and the patient should immediately be heparinized. Heparin, which never causes necrosis, can be used freely if further anticoagulation therapy is required, and may well prevent necrosis due to the thrombotic process.
mesh_terms: D000293:Adolescent; D005260:Female; D006801:Humans; D009336:Necrosis; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced*; D014859:Warfarin / Q000009:adverse effects*
chemical_list: D014859:Warfarin