title: Necrotizing enterocolitis in the neonate.
abstract: Necrotizing enterocolitis has become the most common condition requiring emergency surgical treatment in the newborn infant, far surpassing all major congenital anomalies in number of presentations and in deaths after surgical treatment. No single cause for the disease is known. Necrotizing enterocolitis is characterized by ischemic necrosis of the intestine, with minimal inflammation. In 25 of 50 per cent of patients, surgical resection of gangrenous bowel is necessary. Operation is reserved for infants with intestinal perforation or grangrene. Recent refinements of indications for operation often permit surgical intervention to coincide with the advent of intestinal gangrene. At operation, expeditious resection of frankly necrotic bowel and exteriorization of the marginally viable ends is all that should be attempted. Special problems postoperatively consist of management of sepsis, maintenance of nutrition and vigilant observation for early and late complications, particularly the development of ischemic intestinal stricture.
mesh_terms: D000818:Animals; D001424:Bacterial Infections; D001808:Blood Vessels; D004195:Disease Models, Animal; D004630:Emergencies; D004761:Enterocolitis, Pseudomembranous / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D005260:Female; D006801:Humans; D007225:Infant Food / Q000009:adverse effects; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D008895:Milk, Human; D011182:Postoperative Care; D011183:Postoperative Complications; D011247:Pregnancy; D012039:Regional Blood Flow; D013035:Spasm / Q000150:complications; D013927:Thrombosis / Q000150:complications