title: [Experiences with clindamycin in orthopedic surgery and traumatology].
abstract: 60 cases of orthopedic surgery and traumatology were treated 64 times altogether with an average dose of clindamycin of 3 X 300 mg/day. 40 patients were given clindamycin as preventive treatment. 12 patients were treated for acute infections of the locomotor system and other 8 patients 12 times for chronic osteitis. In the group having received preventive trqatment, infection occurred bu 1 out of 40 patients. As to the 12 cases of acute infections, 10 recovered, 1 improved and 1 patient got worse. Concerning the 12 treatments of 8 patients with chronic osteitis, in 1 case the inactivation of the infection was obtained. 9 cases showed significant improvement whereas in 2 cases an aggravation was noticed. In 5 patients the following side effects occurred: 2 cases of allergic exanthema, 2 cases of mild diarrhoe and 1 case of pyrosis. This study shows that clindamycin is an antibiotic with a broad field of application in orthopedic surgery.
mesh_terms: D000038:Abscess / Q000188:drug therapy; D001424:Bacterial Infections / Q000209:etiology / Q000517:prevention & control*; D002981:Clindamycin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D005597:Fractures, Open / Q000150:complications; D006230:Hand Injuries / Q000150:complications; D006406:Hematoma / Q000150:complications; D006801:Humans; D004204:Joint Dislocations / Q000150:complications; D010000:Osteitis / Q000188:drug therapy / Q000517:prevention & control*; D011183:Postoperative Complications / Q000188:drug therapy / Q000517:prevention & control; D013530:Surgical Wound Infection / Q000188:drug therapy / Q000517:prevention & control*; D014946:Wound Infection / Q000188:drug therapy / Q000517:prevention & control*
chemical_list: D002981:Clindamycin
vernacular_title: Erfahrungen mit Clindamycin in der orthopädisch-traumatologischen Chirurgie.