[Therapy of so-called shock lung. Experimental animal studies of the lung in shock].
1. Under hemorrhagic-traumatic shock conditions the depression of the flow and the pressure in pulmonary arteria and of the pressure in the left atrium was significant. The elevation of the pulmonary vessel resistance was significant, the pulmonary circulation time was longer. The depression of the oxygen partial pressure in arterial and venous blood was significant. 2. In comparison to single re-transfusion of the taken blood, the re-transfusion and application of 6-Methylprednisolone (Urbason; 30 mg/kg) could raise the pulmonary pressure and the flow in the pulmonary arteria and the oxygen pressure in the arterial and venous blood over their basic level. 3. After re-transfusion and simultaneous addition of phenoxybenzamine a renewing shock took place caused by a relative hypovolemia. 4. The hemodynamic circulation in the pulmonary and peripherial vessels was restored by hemodilution. While a single infusion of Haemaccel intensified the hypoxemia in comparison to shock conditions, the infusion of albumin (4%) caused no change in measured values. The application of Urbason (30 mg/kg) combined with Haemaccel-infusions raised the arterial and venous oxygen pressure significantly, in comparison to the hypotonic-phase they exceeded the basic values.
D000818:Animals; D001804:Blood Transfusion, Autologous; D004285:Dogs; D006438:Hemodilution; D006439:Hemodynamics; D008775:Methylprednisolone / Q000627:therapeutic use; D010100:Oxygen / Q000097:blood; D010643:Phenoxybenzamine / Q000494:pharmacology; D011175:Positive-Pressure Respiration; D011652:Pulmonary Circulation; D012128:Respiratory Distress Syndrome / Q000209:etiology / Q000628:therapy*; D012771:Shock, Hemorrhagic / Q000503:physiopathology / Q000628:therapy*; D012774:Shock, Traumatic / Q000503:physiopathology / Q000628:therapy
D010643:Phenoxybenzamine; D010100:Oxygen; D008775:Methylprednisolone
Zur Therapie der sog. Schock-Lunge. Tierexperimentelle Untersuchungen zur lunge im Schock.