title: [Sex factor F of Escherichia coli K12 and its participation in mobilizing bacterial chromosomes].
abstract: The structural and functional organization of F-factor reviewed and the physical map of F DNA, supplemented with a list of genetic markers, is presented. The DNA transfer during the conjugation is considered and especial attention is given to F-gene functions involved in this process. The special sequences of F DNA, homologous to resident insertion sequences in bacterial DNA are described and its participation in plasmido-chromosomal recombinant events both dependent and independent on recA function is discussed. The mechanism for chromosome mobilization by F-Factor are reviewed. A possibility of chromosome transfer without F DNA insertion is considered. In a latter case it proposed that spontaneous single-strand breaks may serve as the origins for initiation of chromosomal transfer.
mesh_terms: D055598:Chemical Phenomena; D002621:Chemistry; D002874:Chromosome Mapping; D002876:Chromosomes, Bacterial / Q000502:physiology*; D003227:Conjugation, Genetic; D004261:DNA Replication; D004269:DNA, Bacterial; D004926:Escherichia coli / Q000235:genetics* / Q000648:ultrastructure; D005144:F Factor; D005796:Genes; D010957:Plasmids; D011995:Recombination, Genetic; D014178:Translocation, Genetic
chemical_list: D004269:DNA, Bacterial
vernacular_title: Polovoi faktor F Escherichia coli K12 i ego uchatie v mobilizatsii bakterial'noĭ khromosomy.