[Hyperacute rejection of renal xenografts after presensitization of the recipients induced by treatment with donor species-specific spleen antigen (author's transl)].
This paper reports about experimental xenografting of kidneys in closely related species (fox/dog) modifying primary graft rejection by pretreatment of the recipients with semisoluble donor species-specific spleen antigen. This kind of pretreatment does not induce immunological enhancement which protects the graft from damage, but causes presensitization of the recipients and subsequently the hyperacute rejection of the transplants. Arteriovenous gradients of platelets and leukocytes as well as those of fibrinogen and clotting factors II, V, VIII, and IX suggest a greater degree of intravascular coagulation within the first minutes after revascularization. Hemagglutinating antibodies induced by pretreatment of the recipients with donor species-specific spleen extract seem to be responsible for the rapidity of rejection and for the reduction of survival time.
D000818:Animals; D000941:Antigens / Q000008:administration & dosage*; D004285:Dogs; D005260:Female; D005589:Foxes / Q000276:immunology*; D006084:Graft Rejection; D006789:Host vs Graft Reaction; D016030:Kidney Transplantation; D008297:Male; D013045:Species Specificity; D013154:Spleen / Q000276:immunology; D014184:Transplantation, Homologous
D000941:Antigens
Hyperakute Abstossung xenogener Nierentransplantate durch Vorsensibilisierung der Empfänger mit spenderspeziesspezifischem Milzantigen.