B cell activity in rat bone marrow and spleen during primary and secondary response: dependence on strength of antigen.
B cell activity was studied in the spleen and the bone marrow of inbred rats after applying xenogeneic erythrocytes of different antigenic strength (mouse or sheep). The hemolytic plaque technique of Cunningham was used. In contrast to the studies of other authors with other species, these experiments showed that in the rat the kinetics of IgM and IgG responses in bone marrow and spleen are principally similar during a primary as well as during a secondary reaction, varying only with the strength of the antigen.
D000818:Animals; D000941:Antigens; D001402:B-Lymphocytes / Q000276:immunology*; D001853:Bone Marrow / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006462:Hemolytic Plaque Technique; D007075:Immunoglobulin M; D051379:Mice; D008809:Mice, Inbred C3H; D051381:Rats; D012756:Sheep; D013154:Spleen / Q000276:immunology*; D013997:Time Factors
D000941:Antigens; D007075:Immunoglobulin M