Studies on oral adjuvants against murine salmonellosis.
1) Attempts were made to develop oral adjuvants against murine salmonellosis. 2) Streptomycin, levamisole and PHA show potential immunoenhancing properties against salmonella infection. 3) The mode of action of these agents remain to be elucidated. Observed results of PHA enhancement may be related to its blastogenic effects in the splenic T-cells. 4) Decrease in certain bacterial flora resulting in less antigenic competition may be the mode of action of streptomycin as adjuvant when added to oral salmonella vaccine.
D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000284:Administration, Oral; D000818:Animals; D001428:Bacterial Vaccines / Q000276:immunology; D001608:Beryllium / Q000276:immunology; D005260:Female; D007978:Levamisole / Q000276:immunology; D051379:Mice; D010567:Pertussis Vaccine / Q000276:immunology; D010835:Phytohemagglutinins; D012481:Salmonella Infections, Animal / Q000276:immunology* / Q000517:prevention & control; D012486:Salmonella typhimurium / Q000276:immunology; D013154:Spleen / Q000276:immunology; D013307:Streptomycin / Q000276:immunology
D000276:Adjuvants, Immunologic; D001428:Bacterial Vaccines; D010567:Pertussis Vaccine; D010835:Phytohemagglutinins; D007978:Levamisole; D001608:Beryllium; D013307:Streptomycin