Modern management of tetanus neonatorum.
Five infants with neonatal tetanus were managed with neuromuscular blockade and positive pressure ventilation. All survived. Tetanus was frequently confused with neonatal seizures at time of presentation. All infants were delivered at home. Mean age of onset of symptoms of poor suck, hypertonicity, and generalized spasms was 5.4 days with hospital admission at 6.4 days. Mean duration of mechanical ventilation was 34 days. Although hospital management of tetanus neonatorum may be expected to have a satisfactory outcome, it represents a costly and complex approach to a preventable disease.
D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000188:drug therapy / Q000451:nursing / Q000628:therapy*; D007385:Intermittent Positive-Pressure Ventilation; D008297:Male; D010197:Pancuronium / Q000008:administration & dosage; D013742:Tetanus / Q000188:drug therapy / Q000451:nursing / Q000628:therapy*; D013743:Tetanus Antitoxin / Q000627:therapeutic use
D006993:Hypnotics and Sedatives; D013743:Tetanus Antitoxin; D010197:Pancuronium