Presence of alpha-1-antitrypsin on mitogen-stimulated human lymphocytes.
Human lymphocytes that have undergone concanavalin A-induced blastogenetic transformation demonstrate surface alpha-1-antitrypsin by immunofluorescence when examined after 72 hr of culture, whereas unstimulated cells do not. These results may indicate a role for alpha-1-antitrypsin in lymphocyte blastogenesis.
D003208:Concanavalin A / Q000494:pharmacology; D005455:Fluorescent Antibody Technique; D006801:Humans; D007106:Immune Sera / Q000494:pharmacology; D007141:Immunoglobulin Fc Fragments; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D008934:Mitogens / Q000494:pharmacology*; D011947:Receptors, Antigen, B-Cell; D000515:alpha 1-Antitrypsin / Q000276:immunology*
D007106:Immune Sera; D007141:Immunoglobulin Fc Fragments; D008934:Mitogens; D011947:Receptors, Antigen, B-Cell; D000515:alpha 1-Antitrypsin; D003208:Concanavalin A