title: The effects and significance of subminimal inhibitory concentrations of antibiotics.
abstract: Subminimal inhibitory concentrations of antibiotics cause structural alterations in gram-positive and gram-negative bacteria and, in certain instances, reduce growth of bacteria, enhance phagocytosis, increase the bactericidal activity of human serum, and induce production of beta-lactamase from gram-negative bacilli. Extrapolation of these in vitro effects to infection in humans is difficult but appears to be most appropriate in patients who receive synergistic combinations of antibiotics.
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001419:Bacteria / Q000187:drug effects* / Q000648:ultrastructure; D018407:Bacterial Physiological Phenomena; D009391:Nephelometry and Turbidimetry; D010406:Penicillins / Q000494:pharmacology; D011513:Proteus mirabilis / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D010406:Penicillins