Disturbed fat absorption following infectious gastroenteritis in children.
Fat absorption was studied in 10 patients recovering from an episode of acute infectious gastroenteritis who failed to gain weight despite adequate caloric intake. Three patients restudied after clinical improvement and three other infants with failure to thrive, unrelated to gastrointestinal problems, served as control subjects. Fat balance studies during the ingestion of a formula containing long-chain fatty acids demonstrated significant degrees of steatorrhea in patients (mean CFA 70.6 +/- 10.7 compared to 90.3 +/- 2.4 in control subjects). The administration of a test meal demonstrated a marked deficiency of duodenal bile acid concentration and of fat incorporation into the micellar phase in patients. Fecal bile acid excretion was significantly increased in patients (mean 33.9 +/- 11.6 microM/kg/day) as compared to control subjects (mean 13.5 +/- 3.1 microM/kg/day). Bacterial overgrowth and abnormalities of the small intestinal mucosa were not constant. Ileal dysfunction and associated bile acid loss are possible causes of disturbed fat assimilation following acute intestinal infection in children.
D000208:Acute Disease; D001647:Bile Acids and Salts / Q000032:analysis; D001826:Body Fluids / Q000032:analysis; D002766:Cholecystokinin; D003968:Diarrhea, Infantile / Q000150:complications; D004041:Dietary Fats / Q000378:metabolism*; D004386:Duodenum; D004927:Escherichia coli Infections / Q000150:complications*; D005243:Feces / Q000032:analysis; D005759:Gastroenteritis / Q000150:complications*; D006801:Humans; D007223:Infant; D007408:Intestinal Absorption; D050356:Lipid Metabolism; D008055:Lipids / Q000032:analysis; D008286:Malabsorption Syndromes / Q000209:etiology*; D008823:Micelles; D012480:Salmonella Infections / Q000150:complications*; D012486:Salmonella typhimurium
D001647:Bile Acids and Salts; D004041:Dietary Fats; D008055:Lipids; D008823:Micelles; D002766:Cholecystokinin