Chemical mediators of immediate hypersensitivity reactions.
The investigation of the mast cell-basophil products has progressed from studies directed solely at implicating histamine or serotonin in allergic diseases to molecular definitions of pathways to target cell activation and mediator release. In addition, within the last several years the detection and molecular characterization of the many other mediators of immediate hypersensitivity have begun. This area should continue to prove a fruitful arena in the future. Identification of the physiologic importance of these mediators in the heaves syndrome or other potential equine allergic syndromes may contribute both to the basic understanding of the pathogenesis of allergy, as well as suggest possible avenues for control.
D000818:Animals; D000937:Antigen-Antibody Reactions; D001491:Basophils / Q000276:immunology; D006493:Heparin / Q000502:physiology; D006632:Histamine / Q000502:physiology; D006734:Horse Diseases / Q000276:immunology*; D006736:Horses; D007073:Immunoglobulin E / Q000032:analysis; D007249:Inflammation; D008407:Mast Cells / Q000276:immunology; D011969:Receptors, Histamine H1 / Q000378:metabolism; D011970:Receptors, Histamine H2 / Q000378:metabolism; D012130:Respiratory Hypersensitivity / Q000276:immunology / Q000662:veterinary*; D013189:SRS-A / Q000502:physiology
D011969:Receptors, Histamine H1; D011970:Receptors, Histamine H2; D013189:SRS-A; D007073:Immunoglobulin E; D006632:Histamine; D006493:Heparin