Partial characterization of a malaria mitogen.
Supernatants from 24-hour cultures of Plasmodium falciparum-infected human red blood cells stimulated lymphocytes from both malaria immune and malaria non-immune donors. Both T and B lymphocytes responded. Amalaria parasite-derived mitogen may play some part in the pathogenesis of the hypergammaglobulinaemia characteristic of malaria.
D002648:Child; D002675:Child, Preschool; D004912:Erythrocytes / Q000276:immunology; D006801:Humans; D006942:Hypergammaglobulinemia / Q000209:etiology; D007075:Immunoglobulin M / Q000096:biosynthesis; D007223:Infant; D007376:Interleukin-2 / Q000032:analysis* / Q000494:pharmacology; D008214:Lymphocytes / Q000378:metabolism; D008222:Lymphokines / Q000032:analysis*; D008288:Malaria / Q000150:complications / Q000276:immunology*; D010835:Phytohemagglutinins / Q000494:pharmacology; D010963:Plasmodium falciparum
D007075:Immunoglobulin M; D007376:Interleukin-2; D008222:Lymphokines; D010835:Phytohemagglutinins