Role of lipids in the immune response. II. An enhancer of antibody production (APS) that is a lipid closely associated with lymphocyte mitogenic factor (LMF).
Lymphocyte mitogenic factor (LMF) is a lymphokine produced by dividing T cells. An activity coeluting with LMF from a Sephadex resin is extractable from LMF with chloroform-methanol. It enhances but does not initiate antibody formation measured by generation of plaque-forming cells (PFC). It does not cause proliferation of B cells. This activity elutes from a silicic acid column and produces a pattern on thin layer chromatography that suggests that the compound(s) responsible for the activity is a polar lipid.
D000917:Antibody Formation; D001402:B-Lymphocytes; D002457:Cell Extracts / Q000276:immunology; D002855:Chromatography, Thin Layer; D005688:Galactosamine / Q000378:metabolism; D005690:Galactose / Q000378:metabolism; D005944:Glucosamine / Q000378:metabolism; D006462:Hemolytic Plaque Technique; D006801:Humans; D008055:Lipids / Q000276:immunology*; D008213:Lymphocyte Activation; D008222:Lymphokines / Q000494:pharmacology*; D012824:Silicic Acid / Q000494:pharmacology
D002457:Cell Extracts; D008055:Lipids; D008222:Lymphokines; D012824:Silicic Acid; D005688:Galactosamine; D005944:Glucosamine; D005690:Galactose