title: Influence of primary prostaglandins, prostacyclin and arachidonic acid on mesenteric hemodynamics in the pig.
abstract: In anesthetized young pigs the influence of intraarterial infusion of prostaglandin E2, prostacyclin, prostaglandin F2 alpha, and arachidonic acid on mesenteric vascular resistance was studied. Infusion of PGE2 and prostacyclin induced a dose-dependent direct decrease in resistance. Infusion of PGF2 alpha resulted in a dose-dependent difference in response. Infusion of lower doses provoked a decrease in mesenteric vascular resistance, whereas infusion of higher doses resulted in an increase. Lower doses of arachidonic acid induced a gradual decrease in resistance, while higher doses provoked biphasic or triphasic responses. After previous blockade of the PG synthetase and lipoxygenase pathways with indomethacin and ETA, arachidonic acid only provoked a decrease in vascular resistance. The resultssuggest a possible role of prostaglandins and their precursors in autoregulation of mesenteric blood flow in the pig.
mesh_terms: D000818:Animals; D001095:Arachidonic Acids / Q000494:pharmacology*; D001783:Blood Flow Velocity; D001794:Blood Pressure / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D011464:Epoprostenol / Q000494:pharmacology; D005260:Female; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D008638:Mesenteric Arteries / Q000187:drug effects*; D011453:Prostaglandins / Q000494:pharmacology*; D011458:Prostaglandins E / Q000494:pharmacology; D011460:Prostaglandins F / Q000494:pharmacology; D013552:Swine / Q000502:physiology*; D014655:Vascular Resistance / Q000187:drug effects*
chemical_list: D001095:Arachidonic Acids; D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; D011464:Epoprostenol; D007213:Indomethacin