Genetic control of anti-DNP response to DNP-BSA given by continuous infusion technique.
Ten inbred strains of mice were administrated with dinitrophenyl-bovine serum albumin (DNP-BSA) at a dose of 30 or 300 microgram/day by continuous infusion technique. Anti-DNP plaque-forming cells (PFC) in their spleens were assayed 10 to 12 days after the beginning of the infusion. NZB, BALB/c, C3H/He and NC strains were high responders to both doses of DNP-BSA. KK, SII and TES strains were low responders at both doses. SJL/J, C57B1/6 and DDD strains were intermediate responders: the antibody response was low to the dose of 30 microgram/day, and high to the dose of 300 microgram/day. Breeding tests between high responder BALB/c and intermediate responder DDD mice indicated that the immune response was largely controlled by a gene linked to the H-2 complex. Similar studies with high responder NZB and low responder TES mice suggested an involvement of a few genes: at least one of the controlling genes may be linked to the H-2 complex.
D000818:Animals; D000917:Antibody Formation; D000941:Antigens; D004136:Dinitrobenzenes / Q000276:immunology*; D006462:Hemolytic Plaque Technique; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D009578:Nitrobenzenes / Q000276:immunology*; D010641:Phenotype; D012710:Serum Albumin, Bovine / Q000276:immunology*
D000941:Antigens; D004136:Dinitrobenzenes; D009578:Nitrobenzenes; D012710:Serum Albumin, Bovine