[Prolonged function time of xenogenic kidney transplants caused by the combined use of azathioprin and prednisolone].
The present publication reports about the delay of the rejection by unspecific medicamentous immuno suppression. This is the continuation of our earlier publication about the unaffected primary rejection of xenogenic kidney transplants in the closely related system fox - dog. The combined application of azathioprine and prednisolone leads to elongated function times of the kidney transplants and to the duplication of survival times of the recipients. Lymphocytotoxins, which are immuno-electrophoretic Ig G antibodies, appear two days later than in untreated recipients by hindrance of immunological reactivity. These obtain however then in consequence of the injured formation of antigen-antibody complexes a concentration increase which widely exceeds the increase of the control groups. The influence of azathioprin and prednisolone on the humoral respectively cellular immunity is talked about in the discussion. Morphological differences in the transplants are not observed in comparison with untreated recipients.
D000818:Animals; D001379:Azathioprine / Q000494:pharmacology; D004285:Dogs; D005589:Foxes; D006085:Graft Survival / Q000187:drug effects*; D007165:Immunosuppression Therapy; D016030:Kidney Transplantation; D011239:Prednisolone / Q000494:pharmacology; D014183:Transplantation, Heterologous
D011239:Prednisolone; D001379:Azathioprine
Verlängerte Funktionszeiten xenogener Nierentransplantate durch kombinierte Anwendung von Azathioprin und Prednisolon.