Effect of intracellular injection of La3+ and Mn2+ on electrical coupling of heart cells.
The effect of intracellular injection of La3+ and Mn2+ on the electrical coupling of canine Purkinje cells investigated. It was found that La3+ causes cell decoupling in about 100 sec, increased the input resistance of the injected cell too. Mn2+ injection reduced drastically the coupling coefficient but did not abolish cell communication. Intracellular injection of La3+ or Mn2+ also caused shortening of the action potential and hyperpolarized the the heart cells. La3+ seems to be as effective as Ca or even stronger than Ca in suppressing intercellular communication in heart fibres.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002450:Cell Communication / Q000187:drug effects; D003584:Cytological Techniques; D004285:Dogs; D006168:Guinea Pigs; D006329:Heart Conduction System / Q000187:drug effects*; D007267:Injections; D007811:Lanthanum / Q000494:pharmacology*; D008345:Manganese / Q000494:pharmacology*; D008564:Membrane Potentials / Q000187:drug effects; D011690:Purkinje Fibers / Q000187:drug effects* / Q000502:physiology
D008345:Manganese; D007811:Lanthanum