Role of the H-2 complex in the homing affinity of injected lymphoid cells to the host's lymph nodes.
The role of H-2 and non-H-2 gene products was studied in a model of non-immune cell-cell interactions which underlie the homing affinity to lymph nodes of injected 51Cr-labelled lymph node cells. The effect of various donor-recipient combinations was tested by comparing the allogeneic/syngeneic ratio of radioactivity recovered from the lymph nodes. The homing affinity was reduced to about 50% when the donor-recipient incompatibility extended over the whole H-2 chromosome. When confined to a single region (H-2K, I or D) H-2 incompatibility caused no significant allogeneic inhibition of the homing affinity. The cumulative effect of two partial incompatibilities (K + I or D + I) was, however, reflected in a significant allogeneic inhibition. Non-H-2 incompatibilities had, as a rule, a weak effect; the non-H-2 gene products may not be directly involved in the cell interactions under test.
D000818:Animals; D001803:Blood Transfusion; D016026:Bone Marrow Transplantation; D002465:Cell Movement; D005260:Female; D006183:H-2 Antigens / Q000235:genetics*; D008198:Lymph Nodes / Q000166:cytology* / Q000637:transplantation; D017710:Lymphocyte Transfusion; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000235:genetics; D010641:Phenotype; D013154:Spleen / Q000637:transplantation; D014181:Transplantation Immunology
D006183:H-2 Antigens