Effect of the LRF-antagonist [D-pGlu1, D-Phe2, D-Trp3,6]-LRF on pregnancy in the rat.
The potent LRF-antagonist [D-pGlu1, D-Phe2, D-Trp3,6]-LRF (Antag.) has been examined for its effect in mated female rats. While 1.25 mg Antag. given b.i.d. for 7 days after mating prolongs pregnancy, the administration of 2.5 mg Antag. b.i.d. for the same period results in the complete absence of developing fetuses.
D000818:Animals; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors*; D009842:Oligopeptides / Q000494:pharmacology*; D011247:Pregnancy / Q000187:drug effects*; D011255:Pregnancy Maintenance / Q000187:drug effects*; D051381:Rats
D009842:Oligopeptides; D007987:Gonadotropin-Releasing Hormone