A simple plate test for screening colicine-inducing substances as a tool for the detection of potential carcinogens.
A simple and rapid plate test is described for screening substances that induce colicine E2. By using chemicals activated with microsomal enzymes and a permeable (rfa) tester bacterium that is also deficient in DNA repair (uvrB), the range of inducing substances that can be detected has been extended. The possible correlation between colicine-inducing substances and carcinogens is discussed.
D001431:Bacteriological Techniques; D002273:Carcinogens / Q000494:pharmacology*; D003087:Colicins / Q000096:biosynthesis*; D003227:Conjugation, Genetic; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D004926:Escherichia coli; D012486:Salmonella typhimurium
D002273:Carcinogens; D003087:Colicins