title: [Administration of equally divided doses of propylthiouracil every two-eight hours in hyperthyroidism].
abstract: Serum propylthiouracil semi splitting occurs in 1.1 and 1.65 hours when administered in a single dose. In this work treatment for hyperthyroid patients is described; 350 mg were administered daily in divided doses, every two and eight hours. In group A fifteen patients received 50 mg every two hours from 8:00 to 20:00 hs. and in group B nine patients were administered 100, 100 and 150 mg at 8 hour intervals. The patients were hospitalized the first seven days and during this time circulating triiodothyronine and thyroxine concentrations were measured daily at 8:00 and 20:00 hrs. and then at 8:00 hrs. at days 8, 14, 21 and 28. After almost one week of treatment, in group "A", seven patients (46.6 per cent p 0.05) had normal concentration levels in both hormones. In group "B" only one patient reached normal levels in the first eight days. The administration of propylthiouracil every two hours is a useful procedure to attain the euthyroid state in less time than with other therapeutic patterns without undesirable side effects.
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011441:Propylthiouracil / Q000008:administration & dosage* / Q000627:therapeutic use; D013607:Tablets; D013997:Time Factors
chemical_list: D013607:Tablets; D011441:Propylthiouracil
vernacular_title: Administración de igual dosis de propiltiouracilo fraccionada cada dos y cada ocho horas en el hipertiroidismo.