Effects of atropine and toxogonine on metabolism of the isolated rat liver changed by diisopropylofluorophosphate (DEP).
Effects of atropine and toxogonine on metabolism of the isolated rat liver changed by diisopropylofluorophosphate (DFP). Acta Physiol., 1979, 30 (2): 289--294. In the investigations on isolated rat liver it was found that DFP in a dose corresponding to 1/2 of the LD50 inhibited the activity of AChE, caused hypoglycaemia, decreased the level or pyruvate and increased that of lactate and hepatic glycogen, and increased the activity of transaminases. Atropine and toxogonine administered separately in a concentration of 0.5 mg/100 ml reduced the pyruvate level without changing the other parameters. Administered together with DFP they reactivated the activity of AChE, abolished hypoglycaemia and antagonized in part the effect of DFP on lactate level and transaminase activity.
D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D001786:Blood Glucose / Q000032:analysis; D007531:Isoflurophate / Q000037:antagonists & inhibitors*; D007773:Lactates / Q000097:blood; D008099:Liver / Q000378:metabolism*; D008112:Liver Glycogen / Q000032:analysis; D008297:Male; D009768:Obidoxime Chloride / Q000494:pharmacology*; D010091:Oximes / Q000494:pharmacology*; D011773:Pyruvates / Q000097:blood; D051381:Rats; D000637:Transaminases / Q000097:blood
D001786:Blood Glucose; D007773:Lactates; D008112:Liver Glycogen; D010091:Oximes; D011773:Pyruvates; D007531:Isoflurophate; D009768:Obidoxime Chloride; D001285:Atropine; D000637:Transaminases