Gold-induced thrombocytopenia responsive to cyclophosphamide.
Thrombocytopenia and nephrotic syndrome developed in a 51-year-old patient receiving gold therapy for rheumatoid arthritis. Marrrow findings and platelet infusion studies were consistent with a pattern of increased platelet destruction, known to occur in gold-induced thrombocytopenia. Improvement in the platelet count after therapy with dimercaprol was transient, and although steroids and splenectomy were not effective, a response was achieved with cyclophosphamide. The use of immunosuppressive drugs can be considered in refractory cases of gold-induced thrombocytopenia in which a significant hemorrhagic risk is present.
D006051:Aurothioglucose / Q000009:adverse effects*; D003520:Cyclophosphamide / Q000627:therapeutic use*; D006046:Gold / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000188:drug therapy
D006051:Aurothioglucose; D006046:Gold; D003520:Cyclophosphamide