title: Effect of pimozide on the response of LH-RH in intact adult male rats.
abstract: The effect of Pimozide on serum and pituitary concentration of LH was studied in adult male intact rats. Also the release of LH under stimulation of exogenous LH-RH was measured. The treatment for 5 days with pimozide did not alter the serum LH levels, decreased the release of LH by exogenous LH-RH stimulation, and increased the pituitary LH concentration. These results would indicate that blocking the dopaminergic receptors alters pituitary LH release mechanism.
mesh_terms: D000818:Animals; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology*; D007986:Luteinizing Hormone / Q000097:blood / Q000378:metabolism*; D008297:Male; D010868:Pimozide / Q000494:pharmacology*; D010902:Pituitary Gland / Q000378:metabolism; D051381:Rats
chemical_list: D010868:Pimozide; D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone