Lymphocyte subpopulations in man: characterization of human killer cells against allogeneic targets sensitized with HLA antibodies.
Human killer cells mediating antibody-dependent cytotoxicity against allogeneic lymphoblasts presensitized with HLA antibodies have been studied by rosette fractionation experiments. Enriched and/or depleted cell suspensions have been tested in dose-response studies. Two different populations can act as killer cells. The major cytotoxic capacity is retained among T cells with high-avidity Fc receptors, whereas a minor cytotoxic capacity was found among non-T cells with high-avidity Fc receptors. These two populations have different dose-response curves, indicating different effector mechanisms.
D003601:Cytotoxicity Tests, Immunologic; D004306:Dose-Response Relationship, Immunologic; D005455:Fluorescent Antibody Technique; D006680:HLA Antigens; D006801:Humans; D007141:Immunoglobulin Fc Fragments; D007518:Isoantibodies; D007694:Killer Cells, Natural / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology*; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology
D006680:HLA Antigens; D007141:Immunoglobulin Fc Fragments; D007518:Isoantibodies