Cytogenetic studies in patients treated with penicillamine.
Cytogenetic studies were performed on bone-marrow cells from 11 patients with rheumatoid arthritis treated with penicillamine. One of the patients was studied while developing a granulocytopenia and thrombocytopenia. The findings show that penicillamine had no chromosome-damaging effect as estimated by the micronucleus test and by the number of structural chromosomal aberrations.
D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D001853:Bone Marrow / Q000648:ultrastructure; D002869:Chromosome Aberrations; D002877:Chromosomes, Human / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005821:Genetic Techniques; D006801:Humans; D008297:Male; D010396:Penicillamine / Q000494:pharmacology* / Q000627:therapeutic use
D010396:Penicillamine