Cupro-zinc superoxide dismutase: a possible biologic marker for alcoholism (studies in black patients).
Cupro-zinc superoxide dismutase (SOD-1) was measured by competition radioimmune assay of erythrocyte lysates of alcoholic and control subjects. Normal amounts of SOD-1 were found in the extract from control subjects (815 ng/mg Hb) and from white alcoholics (874 ng/mg Hb). However, the level of SOD-1 in lysates from black alcoholics (1033 ng/mg Hb) was significantly increased (p = 0.0001, rank sum test) compared with black and white controls. This increase was not related to any other observed hematologic disorder or to any historical, demographic, or laboratory value examined.
D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000097:blood / Q000175:diagnosis / Q000201:enzymology*; D044383:Black People; D003300:Copper / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013482:Superoxide Dismutase / Q000378:metabolism*; D014481:United States; D044465:White People; D015032:Zinc / Q000378:metabolism; D001741:Black or African American
D003300:Copper; D013482:Superoxide Dismutase; D015032:Zinc