Endometrial histology and post-partum mares treated with progesterone and synthetic GnRH (AY-24,031).
Foal heat was significantly delayed in 15 Thoroughbred and Quarter-horse mares by 200 mg progesterone in oil from Days 5--14 post partum. Nine of these mares subsequently received daily i.v. injections of 2 mg of a synthetic GnRH preparation (AY-24,031) from Day 2 of the progesterone-delayed oestrus but this treatment did not significantly shorten oestrus or hasten ovulation. Uterine biopsies taken on Day 15 post partum from all the mares showed a mixed endometrial morphology having both oestrous and dioestrous characteristics. There was an increased proliferation of endometrial glands in these animals at the time of ovulation compared to control mares having a normal foal heat.
D000818:Animals; D004717:Endometrium / Q000166:cytology* / Q000187:drug effects; D004971:Estrus / Q000187:drug effects; D005260:Female; D005298:Fertility / Q000187:drug effects; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology*; D006728:Hormones / Q000494:pharmacology; D006736:Horses / Q000502:physiology*; D010060:Ovulation / Q000187:drug effects; D049590:Postpartum Period / Q000187:drug effects*; D011247:Pregnancy; D011374:Progesterone / Q000494:pharmacology*; D014599:Uterus / Q000382:microbiology
D006728:Hormones; D007987:Gonadotropin-Releasing Hormone; D011374:Progesterone