The influence of daunomycin on development of Yoshida sarcoma after nonspecific stimulation of the immunologic system.
Injection of BCG in rats inoculated with Yoshida sarcoma had no influence on the development of the tumor or survival time of the rats in comparison with the control group. On the other hand, survival time was increased more than threefold in a group of rats injected with daunomycin in a single dose of 1 mg/kg i.p. Longest survival and lowest mortality were observed in a group of rats treated with daunomycin and BCG, in which survival time was six times longer than in the controls, and mortality after 50 days was 30% lower, and after 100 days even 50% lower than in the group of rats that were treated only with daunomycin.
D000818:Animals; D001500:BCG Vaccine; D003630:Daunorubicin / Q000627:therapeutic use*; D005260:Female; D007167:Immunotherapy; D009163:Mycobacterium bovis / Q000276:immunology; D051381:Rats; D012517:Sarcoma, Yoshida / Q000276:immunology / Q000628:therapy*
D001500:BCG Vaccine; D003630:Daunorubicin