[Role of the thymus in regulation of the macrophage migration inhibitory factor production in mice of different genotypes].
The influence of the thymus on the production of the macrophage migration inhibitory factor (MIF) was studied in C57BL and CBA mice thymectomized at 4--6 weeks of age. On the 1--21st day after the operation they were immunized intraperitoneally with complete Freund's adjuvant. MIF production stimulated by tuberculin was determined on the maximum of the immune response. MIF production was abolished in mice of both lines already during the first days. To elucidate a relationship between MIF production and the presence of the thymus the former was investigated in the thymectomized "nude" mice. The mice showed no MIF production. It was found as well that thymectomy can interrupt the immune response in early stages of its development and completely eliminates MIF production the first days after immunization. Moreover, thymectomy in adult mice also changes spontaneous migration of macrophages both in immunized and non-immunized mice. These changes were more pronounced in C57BL mice.
D000818:Animals; D000917:Antibody Formation; D008263:Macrophage Migration-Inhibitory Factors / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013045:Species Specificity; D013934:Thymectomy; D013950:Thymus Gland / Q000276:immunology*
D008263:Macrophage Migration-Inhibitory Factors
Rol' timusa v reguliatsii produktsii faktora, ugnetaiushchego migratsiiu makrofagov, u mysheĭ raznykh genotipov.