Inhibition of insulin secretion from the perfused pancreas of the rat by pizotifen.
1 In the perfused rat pancreas the effects of pizotifen on insulin release induced by 20 mM glucose were studied. 2 Pizotifen (10 and 100 muM) significantly reduced the insulin release during a 25 min perfusion period to 49% and 7% of the controls. 3 The same concentrations of the structurally related agents cyproheptadine, doxepin, and chlorpromazine produced a comparable inhibition.
D000818:Animals; D002746:Chlorpromazine / Q000494:pharmacology; D003533:Cyproheptadine / Q000494:pharmacology; D004316:Doxepin / Q000494:pharmacology; D005947:Glucose / Q000494:pharmacology; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010918:Pizotyline / Q000494:pharmacology*; D051381:Rats; D013876:Thiophenes / Q000494:pharmacology*
D007328:Insulin; D013876:Thiophenes; D010918:Pizotyline; D004316:Doxepin; D003533:Cyproheptadine; D005947:Glucose; D002746:Chlorpromazine