[Acute acoustic trauma. The therapeutic effect of bencyclan in a controlled clinical trial (author's transl)].
In a retrospective study 103 patients with acute acoustic trauma (AAT) were investigated. The control group (53 patients) was treated with Dextran 40 (10% solution), neurotrop vitamins and Betahistin. Bencyclan was administered additionally in the test group (50 patients). Statistical analysis of the audiometric data showed the following results: 1. Mean hearing levels of the test group showed better improvement of threshold shifts, if the therapy started within 2 days or after more than 10 days after the AAT. 2. Regression-and correlation coefficients, however, in a regression analysis of absolute hearing gains and hearing losses before therapy, did not indicate a substantial effect of Bencyclan. 3. Neither did statistical tests with relative hearing gains show any significant differences between test-and control groups. Consequently Bencyclan is not likely to have a positive effect in AAT, if it is administered in the above mentioned way.
D000293:Adolescent; D000328:Adult; D001299:Audiometry; D001537:Bencyclane / Q000627:therapeutic use*; D001621:Betahistine / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003508:Cycloheptanes / Q000627:therapeutic use*; D003911:Dextrans / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006317:Hearing Loss, Noise-Induced / Q000188:drug therapy*; D006801:Humans; D008472:Medazepam / Q000627:therapeutic use; D012189:Retrospective Studies; D012996:Solutions; D014801:Vitamin A / Q000627:therapeutic use; D014810:Vitamin E / Q000627:therapeutic use
D003508:Cycloheptanes; D003911:Dextrans; D012996:Solutions; D014801:Vitamin A; D014810:Vitamin E; D001537:Bencyclane; D008472:Medazepam; D001621:Betahistine
Akutes akustisches Trauma: Die therapeutische Wirksamkeit von Bencyclan im kontrollierten klinischen Vergleich.