[Interrelationships between the virulence and the presence of M-protein in hemolytic streptococcus group A].
Experiments on mice demonstrated that of hemolytic streptococci A M types 2, 3, 12, 22, 46, and 49 characteristic is the absence of parallelism between their virulence for mice and the presence of M+-colonies in the microbial population. There was also a greater virulence for mice of M-variants. The established changes in serological properties of the cultures passaged in vitro were brought to the acquisition of polyagglutinability by the passage cultures, and to the loss of type-specific protection by the immune sera against these cultures. A possibility of acquisition by passage cultures of a factor determining their high virulence for mice, nonidentical to M-protein, is discussed.
D000818:Animals; D001426:Bacterial Proteins / Q000276:immunology / Q000494:pharmacology*; D014644:Genetic Variation; D006386:Hemagglutination Tests; D007106:Immune Sera / Q000008:administration & dosage; D051379:Mice; D011817:Rabbits; D012703:Serotyping; D013290:Streptococcal Infections / Q000382:microbiology; D013297:Streptococcus pyogenes / Q000276:immunology / Q000472:pathogenicity*; D014774:Virulence
D001426:Bacterial Proteins; D007106:Immune Sera
Vzaimootnosheniia mezhdu virulentnost'iu i nalichiem M-belka u gemoliticheskikh streptokokkov gruppy A.