Effect of platinum compounds on murine lymphocyte mitogenesis.
Polyclonal activation of T and B lymphocytes by concanavalin A and lipopolysaccharide mitogens, respectively, was used to study the effect of iv injection of the following platinum compounds: cis-dichlorodiammine platinum, dichloro 1,2 benzenediamine N,N' platinum, cis-dichlorobis(cyclohexylamine) platinum, and cis-dichlorobis(cyclopentylamine) platinum, on murine T and B splenic lymphocytes. The results indicated that platinum compounds were more toxic to T-lymphocyte function than to B-lymphocyte function. These results were from both single-dose-time-course analysis and dose-response studies.
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology* / Q000187:drug effects; D003208:Concanavalin A / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D008070:Lipopolysaccharides / Q000494:pharmacology; D051379:Mice; D008938:Mitosis / Q000187:drug effects*; D010984:Platinum / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000166:cytology* / Q000187:drug effects; D013997:Time Factors
D008070:Lipopolysaccharides; D003208:Concanavalin A; D010984:Platinum