title: The chemiluminescence response and bactericidal activity of polymorphonuclear neutrophils from newborns and their mothers.
abstract: Chemiluminescence (CL) was measured in the polymorphonuclear neutrophils (PMN) of 18 normal term infants, their mothers, and controls during phagocytosis of opsonized zymosan particles. Chemiluminescence was significantly lower in the PMN of newborns in comparison with the PMN of their mothers and of the controls. Depressed bactericidal activity was demonstrated in newborn PMN, in comparison with the activity of the PMN of their mothers and controls, when challenged with Escherichia coli at large bacteria-PMN ratios. Uptake of radio-labeled bacteria by PMN was identical in newborns, mothers, and controls, which indicates that reduced CL was not a result of impaired ingestion. Therefore, PMN of normal term infants have both depressed oxidative metabolic responsiveness as measured by CL and depressed bactericidal capacity.
mesh_terms: D000328:Adult; D001770:Blood Bactericidal Activity; D004926:Escherichia coli; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009035:Mothers; D009504:Neutrophils / Q000502:physiology*; D009895:Opsonin Proteins / Q000502:physiology*; D010587:Phagocytosis; D013211:Staphylococcus aureus; D015054:Zymosan
chemical_list: D009895:Opsonin Proteins; D015054:Zymosan