The effect of inhibitors of prostaglandin synthesis in primary dysmenorrhea studied with hysterometry.
The technique called hysterometry has been used for the quantitative evaluation of effect of naproxen sodium and naproxen on myometrial tension in vivo during dysmenorrhea. It was observed that "uterine tonicity" - the datum arrived at after hysterometric recording - decreased significantly during naproxen medication in comparison with placebo treatment. Decrease in uterine tonicity was well correlated with relief of pain.
D000293:Adolescent; D000328:Adult; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004341:Drug Evaluation; D004412:Dysmenorrhea / Q000188:drug therapy* / Q000378:metabolism; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D008598:Menstruation; D008722:Methods; D009129:Muscle Tonus / Q000187:drug effects; D009288:Naproxen / Q000097:blood / Q000627:therapeutic use*; D010919:Placebos; D011374:Progesterone / Q000097:blood; D011453:Prostaglandins / Q000096:biosynthesis*; D014590:Uterine Contraction / Q000187:drug effects
D010919:Placebos; D011453:Prostaglandins; D011374:Progesterone; D004958:Estradiol; D009288:Naproxen