title: Subcutaneous Corynebacterium parvum in bladder cancer: a controlled study of its immunological effects.
abstract: Fourteen out of 26 patients with invasive bladder cancer were randomly assigned to receive weekly subcutaneous injections of Corynebacterium parvum (CP) in addition to standard treatment. Peripheral blood T lymphocyte percentage, K cell activity, mitogen responsiveness, and monocyte and polymorph leucotaxis were measured at intervals over a period of 1 to 2 years. The only consistent difference between the CP-treatment patients and the controls was a slightly higher level of K cell activity in the former, who, however, fared rather worse than the controls in terms of survival.
mesh_terms: D002470:Cell Survival; D002478:Cells, Cultured; D002634:Chemotaxis, Leukocyte; D002986:Clinical Trials as Topic; D006801:Humans; D007279:Injections, Subcutaneous; D008214:Lymphocytes / Q000276:immunology; D008934:Mitogens / Q000494:pharmacology; D009000:Monocytes / Q000276:immunology; D009504:Neutrophils / Q000276:immunology; D011425:Propionibacterium acnes / Q000276:immunology*; D001743:Urinary Bladder / Q000601:surgery; D001749:Urinary Bladder Neoplasms / Q000276:immunology / Q000628:therapy*
chemical_list: D008934:Mitogens