Location of brown recluse venom attachment sites on human erythrocytes by the firritin-labeled antibody technique.
Brown recluse spider (loxosceles reclusa) venom has been demonstrated by a ferritin-labeled antibody technique to attach to human erythrocyte cell membranes. The number of individual attachment sites per cell is proportional to the concentration of the venom used to sensitize the erythrocytes. Structural changes in the red cell membrane are associated with the venom attachment. These sites may be related to the red cell hemolysis which sometimes occurs in the human as a result of the spider bite.
D000818:Animals; D001180:Arthropod Venoms / Q000276:immunology*; D001666:Binding Sites, Antibody; D002462:Cell Membrane / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D004912:Erythrocytes / Q000276:immunology* / Q000648:ultrastructure; D005260:Female; D005293:Ferritins; D006801:Humans; D007158:Immunologic Techniques; D013111:Spider Venoms / Q000276:immunology*; D013112:Spiders
D001180:Arthropod Venoms; D013111:Spider Venoms; D005293:Ferritins