title: Practical aspects of selection of streptomyces mutants.
abstract: The methods of industrial strains selection on the basis of some regulatory mechanisms are presented. The selection of the producing S. erythreus mutants exhibiting higher activity for transformation of erythromycin C to erythromycin A is one of the examples for the practical use of the presented method. Some new techniques including isotopic methods are presented.
mesh_terms: D001431:Bacteriological Techniques; D003470:Culture Media; D004917:Erythromycin / Q000096:biosynthesis*; D008034:Lincomycin / Q000096:biosynthesis*; D009154:Mutation; D011422:Propionates / Q000494:pharmacology; D013302:Streptomyces / Q000235:genetics* / Q000378:metabolism
chemical_list: D003470:Culture Media; D011422:Propionates; D004917:Erythromycin; D008034:Lincomycin