Medical treatment of endometriosis: a comparative trial.
In a comparison of danazol, and mestranol with norethynodrel (Enavid, Searle) in the treatment of endometriosis danazol was shown to be superior. Danazol is however relatively ineffective when large tumours or extensive adhesions are present and such patients will usually need a surgical operation. Women who have completed their families and who have severe symptoms will be better treated by hysterectomy. Treatment with danazol is indicated for young women with mild or moderate endometriosis. Danazol treatment may also be given postoperatively after conservative operations.
D001835:Body Weight / Q000187:drug effects; D002986:Clinical Trials as Topic; D003613:Danazol / Q000009:adverse effects / Q000627:therapeutic use*; D004338:Drug Combinations; D004715:Endometriosis / Q000188:drug therapy*; D005260:Female; D005833:Genital Neoplasms, Female / Q000188:drug therapy*; D006801:Humans; D008656:Mestranol / Q000627:therapeutic use; D009641:Norethynodrel / Q000627:therapeutic use; D011245:Pregnadienes / Q000627:therapeutic use*
D004338:Drug Combinations; D011245:Pregnadienes; D009641:Norethynodrel; D008656:Mestranol; D003613:Danazol