Effects of subminimal inhibitory concentrations of antibiotics on adhesiveness of Escherichia coli in vitro.
The adhesion of radiolabeled Escherichia coli (strain SS142) to monolayers of Intestine 407, a human epithelioid tissue culture cell line, was investigated. In this assay the adhesion of bacteria grown in the presence of subminimal inhibitory concentrations of tetracycline, clindamycin,, or trimethoprim-sulfametrole was reduced in a manner that was dose dependent. In contrast, at such concentrations nalidixic acid enhanced the adhesion of this bacterial strain, and other antibiotics-e.g., penicillin G, ampicillin, mecillinam, cephacetrile, cephalexin, cefotaxime, chloramphenicol, and streptomycin-did not affect its adhesiveness.
D000268:Adhesiveness; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002478:Cells, Cultured; D002981:Clindamycin / Q000008:administration & dosage; D004848:Epithelium / Q000382:microbiology; D004926:Escherichia coli / Q000187:drug effects* / Q000472:pathogenicity; D006801:Humans; D066298:In Vitro Techniques; D007422:Intestines / Q000382:microbiology; D009268:Nalidixic Acid / Q000008:administration & dosage; D010400:Penicillin G / Q000008:administration & dosage; D013424:Sulfanilamides / Q000008:administration & dosage; D013752:Tetracycline / Q000008:administration & dosage; D014295:Trimethoprim / Q000008:administration & dosage
D000900:Anti-Bacterial Agents; D013424:Sulfanilamides; D009268:Nalidixic Acid; D002981:Clindamycin; D014295:Trimethoprim; C012047:sulfametrole; D013752:Tetracycline; D010400:Penicillin G