Mutagenic and alkylating metabolites of halo-ethylenes, chlorobutadienes and dichlorobutenes produced by rodent or human liver tissues. Evidence for oxirane formation by P450-linked microsomal mono-oxygenases.
D000475:Alkenes / Q000378:metabolism / Q000494:pharmacology; D000477:Alkylating Agents; D000818:Animals; D001711:Biotransformation; D002070:Butadienes / Q000378:metabolism / Q000494:pharmacology; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D005027:Ethylene Oxide / Q000378:metabolism* / Q000494:pharmacology; D005030:Ethylenes / Q000378:metabolism / Q000494:pharmacology; D005260:Female; D006801:Humans; D006846:Hydrocarbons, Halogenated / Q000378:metabolism* / Q000494:pharmacology; D051379:Mice; D008862:Microsomes, Liver / Q000378:metabolism*; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D009153:Mutagens; D010088:Oxidoreductases / Q000378:metabolism*; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects; D013997:Time Factors
D000475:Alkenes; D000477:Alkylating Agents; D002070:Butadienes; D005030:Ethylenes; D006846:Hydrocarbons, Halogenated; D009153:Mutagens; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D010088:Oxidoreductases; D005027:Ethylene Oxide