The formation of altered enzymes in aging animals.
Evidence is accumulating which supports the idea that the alteration of enzymes is due to post-synthetic modifications rather than to sequence changes. Although unequivocal proof is still lacking, the idea that the changes in old enzymes are due to a subtle denaturation rather than to covalent changes is strengthened by recent work. That altered enzymes may result from a slowed protein turnover in old organisms appears to be a viable hypothesis.
D000375:Aging; D000595:Amino Acid Sequence; D000818:Animals; D004798:Enzymes / Q000378:metabolism; D006358:Hot Temperature; D006801:Humans; D008968:Molecular Conformation; D011489:Protein Denaturation; D011506:Proteins / Q000378:metabolism
D004798:Enzymes; D011506:Proteins