[On the molecular mechanism of action of (+)-cyanidanol-3 (author's transl)].
The pharmacological actions of (+)-cyanidanol-3 [(+)-flavan-3,3',4',5,7-pentol, (+)-catechin, Catergen) in various experimental liver diseases are described according to the recent available literature. On this basis the hepatoprotective activity of the drug is due to its stabilizing effect on biological membranes and its specific inhibitory activity on the Fe-ADP-, CCl4- and CBrCl3- stimulated lipoperoxidation in vitro and in vivo.
D000818:Animals; D001578:Benzopyrans / Q000494:pharmacology*; D002392:Catechin / Q000494:pharmacology* / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy / Q000378:metabolism; D005688:Galactosamine / Q000494:pharmacology; D008054:Lipid Peroxides / Q000096:biosynthesis; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008107:Liver Diseases / Q000188:drug therapy / Q000378:metabolism; D008566:Membranes / Q000187:drug effects; D010590:Phalloidine / Q000506:poisoning
D001578:Benzopyrans; D008054:Lipid Peroxides; D010590:Phalloidine; D005688:Galactosamine; D002392:Catechin
Zum molekularen Wirkungsmechanismus von (+)-Cyanidanol-3.