Pretransplant cytotoxic antibodies do not segregate kidney transplant recipients into responder and non-responder groups.
In a study of 687 primary cadaver transplants, we found no correlation between the degree of presensitisation and graft survival. Graft survival was adversely affected in non-transfused recipients and was significantly improved in trnasfused recipients, independent of the level of presensitisation (63%, 61%, 67% at one year for patients with 0-10%, 11-50%, and 51-100% preformed cytotoxic antibodies, respectively). Humoral presensitisation to HLA antigens does not reflect the immunoresponsiveness of the host to the renal allograft, but it may prolong the wait for a compatible donor kidney.
D000961:Antilymphocyte Serum; D001803:Blood Transfusion; D002102:Cadaver; D004306:Dose-Response Relationship, Immunologic; D006085:Graft Survival; D006650:Histocompatibility Testing; D006801:Humans; D016030:Kidney Transplantation; D013997:Time Factors; D014184:Transplantation, Homologous
D000961:Antilymphocyte Serum