[Calorimetric study of the effect of salicylate in man during heat exposure and exercise (author's transl)].
1. The effect of sodium acetylo-salicylate (2 g per os) on the thermoregulatory responses of 10 male subjects was studied by direct and indirect calorimetry during two tests : heat exposure at 37 degrees C and exercise (50 W) at 25 degrees C. Both test were performed twice : with salicylate treatment and with a placebo. 2. During heat exposure at 37 degrees C for 75 min, the rise in tympanic temperature (Tty) and in mean skin temperature Ts, the time course of heat losses by radiation (R), convection (C) and evaporation (E), and the metabolic rate (M), measured by oxygen consumption, were not altered by salicylate treatment. 3. During exercise, salicylate treatment did not affect the time course of Tty and Ts, (R + C) and M. However, salicylate treatment decreased the delay for triggering the evaporative response (E) to the thermal load; similarly, the increase in cutaneous blood flow was triggered sooner in subjected receiving salicylate than in controls. 4. In conclusion, these results suggest that, during exercise, the thermal controller triggers thermoregulatory responses during passive hyperthermia by heat exposure.
D000328:Adult; D001810:Blood Volume / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D001833:Body Temperature Regulation / Q000187:drug effects*; D002151:Calorimetry; D002986:Clinical Trials as Topic; D005334:Fever / Q000209:etiology* / Q000378:metabolism; D006358:Hot Temperature / Q000009:adverse effects*; D006801:Humans; D005082:Physical Exertion; D010919:Placebos; D012881:Skin Temperature / Q000187:drug effects; D012980:Sodium Salicylate / Q000008:administration & dosage / Q000494:pharmacology*
D010919:Placebos; D012980:Sodium Salicylate
Etude calorimétrique de l'effet du salicylate chez l'homme lors de l'hyperthermie induite par exposition au chaud ou par exercice musculaire.