title: Experimental lepromatous leprosy in the white-handed gibbon (Hylobatus lar): successful inoculation with leprosy bacilli of human origin.
abstract: Leprosy bacilli of human origin were inoculated into a white-handed gibbon by the i.v. and i.p. routes, and also locally into ears, testis and around an ulnar nerve. The animal was observed closely during a period of nearly 15 years and did not exhibit any clinical evidence of cutaneous or neurological disease. At death, a wide range of tissues was taken for bacterial counts and histological examination, and a disseminated and progressive infection was demonstrated. Acid-fast bacilli were found in many sites; their morphological appearance distribution in nerves, and pattern of multiplication in mouse foot-pads, and also the presence of anti-mycobacterial antibody in the serum and the absence of specific lymphocyte transformation were all in keeping with an infection by Mycobacterium leprae, at an early lepromatous stage. This is probably the first fully documented report of experimental lepromatous infection in a primate. The findings are discussed in relation to the long incubation period of le promatous leprosy and the difficulties of diagnosing the disease at an early stage in man.
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D004195:Disease Models, Animal; D006614:Hindlimb / Q000473:pathology; D015186:Hominidae / Q000033:anatomy & histology*; D006922:Hylobates / Q000033:anatomy & histology*; D007918:Leprosy / Q000276:immunology / Q000473:pathology*; D008297:Male; D009167:Mycobacterium lepraemurium / Q000302:isolation & purification / Q000472:pathogenicity; D014459:Ulnar Nerve / Q000473:pathology
chemical_list: D000907:Antibodies, Bacterial