The polyene macrolide antibiotics.
The mode of action of the polyene antibiotics is reviewed together with the effect of genetic and environmental factors on sensitive organisms. The future prospects of polyenes in the treatment of systemic mycoses are considered.
D000666:Amphotericin B / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002176:Candida albicans / Q000187:drug effects / Q000648:ultrastructure; D002473:Cell Wall / Q000648:ultrastructure; D004352:Drug Resistance, Microbial; D005658:Fungi / Q000187:drug effects*; D006801:Humans; D011090:Polyenes / Q000494:pharmacology* / Q000627:therapeutic use; D012441:Saccharomyces cerevisiae / Q000187:drug effects
D000935:Antifungal Agents; D011090:Polyenes; D000666:Amphotericin B