Effect of non-steroidal antiinflammatory drugs on some biological activities dependent on complement activation.
The paper presents the results of a study on the action of five non-steroidal antiinflammatory agents (phenylbutazone, indometacin, acetylsalicylic acid, niflumic and flufenamic acids) on two biological activities which are dependent on complement activation: opsonization of bacteria and membrane damage, the latter evaluated both with the classic immunohemolytic system and with a bactericidal assay. The three biological assays differ for complement sequences involved. Flufenamic and niflumic acids showed high inhibitory activity in the lytic assays. Human complement was more sensitive to inhibition than guinea-pig complement. Phagocytic test confirmed the inhibitory activity of flufenamic acid on complement dependent opsonization.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects; D003167:Complement Activation; D003165:Complement System Proteins / Q000502:physiology*; D004926:Escherichia coli / Q000187:drug effects; D006168:Guinea Pigs; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D010587:Phagocytosis / Q000187:drug effects; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D003165:Complement System Proteins