Inhibition of Escherichia coli biodegradative threonine dehydratase by pyruvate.
Pyruvate inhibits Escherichia coli K-12 biodegradative threonine dehydratase activity by a mechanism distinct from product inhibition by alpha-ketobutyrate and catabolite inactivation by intermediary metabolites.
D000249:Adenosine Monophosphate / Q000378:metabolism; D001673:Biodegradation, Environmental; D002087:Butyrates / Q000494:pharmacology; D002474:Cell-Free System; D004926:Escherichia coli / Q000201:enzymology*; D011773:Pyruvates / Q000494:pharmacology*; D013912:Threonine / Q000378:metabolism; D013913:Threonine Dehydratase / Q000037:antagonists & inhibitors* / Q000378:metabolism
D002087:Butyrates; D011773:Pyruvates; D013912:Threonine; D000249:Adenosine Monophosphate; D013913:Threonine Dehydratase