Sodium nitroprusside induced hypotension and isovolemic hemodilution in dogs.
Hypotension at 70 mm Hg was induced with sodium nitroprusside in 6 hemodiluted and 6 control dogs. In contrast to the control dogs, the reduction in mean arterial pressure was not primarily due to the peripheral resistance reduction, but the result of a hazardous fall in cardiac output.
D000136:Acid-Base Equilibrium / Q000187:drug effects; D000818:Animals; D001784:Blood Gas Analysis; D001794:Blood Pressure / Q000187:drug effects*; D002302:Cardiac Output / Q000187:drug effects; D002986:Clinical Trials as Topic; D003911:Dextrans / Q000008:administration & dosage; D004285:Dogs; D005292:Ferricyanides / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006400:Hematocrit; D006438:Hemodilution; D006454:Hemoglobins; D007022:Hypotension / Q000139:chemically induced*; D009599:Nitroprusside / Q000494:pharmacology*; D013997:Time Factors
D003911:Dextrans; D005292:Ferricyanides; D006454:Hemoglobins; D009599:Nitroprusside