Active enhancement of dog kidney allografts using ALG and donor platelets.
The results of the studies indicate that platelets can be used as donor specific antigen in protocols of "biological suppression". Administration of donor specific platelets 10 days after transplantation to unmatched mongrel dogs treated for a brief period with ALG resulted in a marked prolongation of kidney allograft survival. Acute rejection of a second kidney from an indifferent donor suggests that a state of specific unresponsiveness was achieved by recipients pretreatment with ALG and donor antigen challenge.
D000818:Animals; D000961:Antilymphocyte Serum; D001792:Blood Platelets / Q000276:immunology*; D004285:Dogs; D006084:Graft Rejection; D006085:Graft Survival; D006649:Histocompatibility Antigens; D007165:Immunosuppression Therapy; D007668:Kidney / Q000473:pathology; D016030:Kidney Transplantation; D013268:Stimulation, Chemical; D013601:T-Lymphocytes / Q000276:immunology; D014184:Transplantation, Homologous
D000961:Antilymphocyte Serum; D006649:Histocompatibility Antigens