[Cimetidine in the treatment of the active duodenal ulcer].
Thirty six patients with active duodenal ulcers were studied in this double blind work. 19 received placebo and 17 Cimetidine: 1 gr./day. The endoscopic control after 21 days, showed healing in 81,2% of the cases treated with Cimetidine and in 22,2% of those with placebo. After 42 days of continous treatment with Cimetidine the healing of duodenal ulcers was 82,3% against 50% with placebo; the difference being highly statestically significant; p less than 0.01. The symptoms improved with Cimetidine revealing less diurnal and nocturnal pain complete disappearance of nausea and vomit and a significant decreased ingestion of alkali tablets.
D000293:Adolescent; D000328:Adult; D002927:Cimetidine / Q000008:administration & dosage / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003404:Creatinine / Q000378:metabolism; D004311:Double-Blind Method; D004381:Duodenal Ulcer / Q000000981:diagnostic imaging / Q000188:drug therapy*; D004724:Endoscopy; D005750:Gastric Juice / Q000378:metabolism; D006146:Guanidines / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D010919:Placebos / Q000627:therapeutic use; D011859:Radiography; D000637:Transaminases / Q000378:metabolism
D006146:Guanidines; D010919:Placebos; D002927:Cimetidine; D003404:Creatinine; D000637:Transaminases
Cimetidina en el tratamiento de la úlcera duodenal activa.