title: Lead poisoning from a gunshot wound. Report of a case and review of the literature.
abstract: A man was hospitalized on three occasions for symptoms of lead intoxication 20 to 25 years after a gunshot wound that resulted in retention of a lead bullet in his hip joint. The potential for lead toxicity as a complication of a lead missile injury appears to be related to (1) the surface area of lead exposed for dissolution, (2) the location of the lead projectile, and (3) the length of time during which body tissues are exposed to absorbable lead. Cases of lead poisoning of immediate onset resulting from lead shot have been reported in Europe, but all documented cases of ammunition-related plumbism reported in the United States have involved synovial fluid dissolution of a single lead bullet over many years. The solvent characteristics of synovial fluid and associated local arthritis are apparently important factors in the dissolution and absorption of lead from projectiles located in joints. Awareness that lead intoxication can be a complication of retained lead projectiles should allow rapid institution of appropriate diagnostic and therapeutic modalities when such a clinical situation arises.
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced / Q000175:diagnosis; D000293:Adolescent; D000328:Adult; D000743:Anemia, Hemolytic / Q000139:chemically induced / Q000175:diagnosis; D001168:Arthritis / Q000150:complications; D001927:Brain Diseases / Q000139:chemically induced / Q000175:diagnosis; D003937:Diagnosis, Differential; D005547:Foreign Bodies / Q000150:complications; D025981:Hip Injuries; D006801:Humans; D007855:Lead Poisoning / Q000175:diagnosis / Q000209:etiology*; D008297:Male; D014948:Wounds, Gunshot / Q000150:complications*