The effect of polysaccharide-protein complex isolated from Candida albicans on regional blood flow in rats.
After i.v. administration to rats of polysaccharide-protein complex, isolated from Candida albicans, a decrease of cardiac output was observed from 20 sec to 240 min postinjection, followed by a recovery at 360 min. Concomitantly the regional blood flow was maintained in heart and lungs, moderately decreased in intestine, liver and adrenals and markedly reduced in skin, muscle, spleen and kidney.
D000818:Animals; D001775:Blood Circulation / Q000187:drug effects*; D002176:Candida albicans; D002302:Cardiac Output / Q000187:drug effects*; D003326:Coronary Circulation / Q000187:drug effects; D005656:Fungal Proteins / Q000494:pharmacology*; D007422:Intestines / Q000098:blood supply; D007668:Kidney / Q000098:blood supply; D008102:Liver Circulation / Q000187:drug effects; D008297:Male; D011134:Polysaccharides / Q000494:pharmacology*; D011652:Pulmonary Circulation / Q000187:drug effects; D051381:Rats; D012039:Regional Blood Flow / Q000187:drug effects; D013154:Spleen / Q000098:blood supply
D005656:Fungal Proteins; D011134:Polysaccharides