title: [Various blood-foreign body reactions in the heart-lung machine in heart valve replacement and aortocoronary bypass operations].
abstract: Blood-foreign material interaction in the pump oxygenator was studied by means of scanning electron microscopy in 3 patients undergoing heart valve replacement (HVR) and 3 patients undergoing coronary bypass operation (CBO). While polyvinyl tubes show an average deposit of 60 thrombi/mm2 with 20--40 microns in size in CBO, bloodgas interface during HVR causes increasing thrombotic deposits (375 Mcthr/nm2, 25--50 microns in size). Distal to the pump the volume of particles may rise up 250 micrometer in HVR and up to 80 micrometer in CBO. In a 35 micrometer pore arterial-line-filter (Pall-Corporation) platelet clumps up to 1 mm in size are removed from circulating blood in HVR, and up to 300 micrometer thrombi in CBO. According to different platelet deposit proximal to the filter, more and larger thrombi can pass through the filter in HVR. Distal to the pump thromboemboli of 30--60 (maximum 90) micrometer in size can be observed in HVR. Particles of 20--35 (maximum 60) micrometer in size may pass through the filter and enter into the patient's circulation in CBO. As the results suggest, extracorporal circulation is more harmful for patients undergoing HVR than for those undergoing CBO.
mesh_terms: D001773:Blood Cells / Q000648:ultrastructure; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D005112:Extracorporeal Circulation / Q000295:instrumentation; D005549:Foreign-Body Reaction / Q000150:complications* / Q000473:pathology; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006801:Humans; D010974:Platelet Aggregation; D011145:Polyvinyls; D013927:Thrombosis / Q000209:etiology* / Q000473:pathology
chemical_list: D011145:Polyvinyls
vernacular_title: Unterschiedliche Blutfremdkörperreaktion in der Herzlungenmaschine bei Herzklappenersatz- und aortocoronaren Bypass-Operationen.