title: [Clinico-pathological correlations in lupus nephritis with reference to therapeutic and prognostic aspects (author's transl)].
abstract: Since 1970 in 27 out of 46 patients with the diagnosis of systemic lupus erythematosus (SLE) a renal biopsy could be taken. The morphological outcome was followed in 14 patients with a total of 18 repeated biopsies. By light- and electron microscopy renal involvement was demonstrable in all patients. Four histologic subgroups could be differentiated: Mesangio-proliferative (MESLN, 14), focal proliferative (FLN, 6), diffus proliferative (DLN, 6), and membranous lupus nephritis (MLN, 1). Some biopsies demonstrated linear deposits with IgG/IgA-specificity. 2/27 patients only showed a clinical deteriorating course with progressive renal insufficiency despite steroid or steroid-azathioprine therapy. One patient with DLN died in terminal renal failure. The morphological follow-up showed an unfavourable course in 3/14 patients only. One MESLN demonstrated a transition to DLN, one DLN an increase of proliferative lesions and a second DLN focal and local sclerosis. In our experience renal involvement in SLE can adequately characterised and controlled by repeated be clinico-pathological correlations an aggressive therapeutic regimen is not indicated and can be avoided.
mesh_terms: D001379:Azathioprine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology; D007668:Kidney / Q000473:pathology* / Q000648:ultrastructure; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008297:Male; D009393:Nephritis / Q000209:etiology / Q000628:therapy*; D011379:Prognosis; D013256:Steroids / Q000627:therapeutic use
chemical_list: D013256:Steroids; D001379:Azathioprine
vernacular_title: Klinisch-morphologische Korrleationen der Lupus Nephritis unter Berücksichtigung therapeutischer und prognostischer Aspekte.