[Experimental characteristics of the antileishmaniasis action of amphotericin B].
The efficacy of amphotericin B powder of the Soviet production was studied as a therapeutic agent in experimental zoonotic leishmaniosis of the skin form of mice and hamsters. Amphotericin B was administered per os and its action was compared with that of monomycin injected subcutaneously (50 mg/kg). Amphotericin B in a dose of 150 mg/kg administered for 30 days protected 96+/-0.07 and 76.4+/-0.9 per cent of the mice and hamsters respectively from development of the leishmaniosis clinical signs, 68.8+/-0.04 per cent of the animals being cured (in the treatment experiments). The effect of the antibiotic was analogous to that of monomycin administered parenterally. The study of the kinetics of amphotericin B showed that the antibiotic was well absorbed from the digestive tract of the animals into the blood which provided the chemotherapeutic effect.
D000666:Amphotericin B / Q000627:therapeutic use*; D000818:Animals; D000981:Antiprotozoal Agents; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D015643:Erythromycin Ethylsuccinate / Q000627:therapeutic use; D007700:Kinetics; D007896:Leishmaniasis / Q000188:drug therapy*; D008297:Male; D008647:Mesocricetus; D051379:Mice; D013997:Time Factors
D000981:Antiprotozoal Agents; D015643:Erythromycin Ethylsuccinate; D000666:Amphotericin B
Eksperimental'naia kharakteristika protivoleĭshmanioznogo deĭstviia amfoteritsina B.