Applications of chromatography in the standardization and control of biological products.
The problems posed in the standardization of medicinal biological products and in the development of official specifications for such products, e.g., in pharmacopoeias, are outlined. Information derived from bioassay can be extended and complemented by that from physico-chemical studies. The role of chromatography, including gas--liquid, thin-layer and column methods, is assessed and illustrated with examples from the literature and from the author's studies on antibiotics and polypeptide hormones.
D000900:Anti-Bacterial Agents / Q000032:analysis*; D002845:Chromatography / Q000379:methods*; D002849:Chromatography, Gas / Q000379:methods; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D002855:Chromatography, Thin Layer / Q000379:methods; D006728:Hormones / Q000032:analysis*; D007328:Insulin / Q000032:analysis; D010121:Oxytocin / Q000032:analysis; D011863:Radioimmunoassay / Q000379:methods; D012015:Reference Standards
D000900:Anti-Bacterial Agents; D006728:Hormones; D007328:Insulin; D010121:Oxytocin