title: Effect of sodium and osmolarity on renin secretion.
abstract: The effect of changes in sodium and osmolarity on renin secretion has been studied in the isolated perfused rat kidney. Perfusion with low sodium buffer (110 mM/l) produced a significant increase in renin secretion compared with control experiments (Na+:135 mM/l). Since the presence of tubules seems necessary for such an effect to take place, it suggests that the high renin secretion stimulated by a low sodium buffer centers in the Macula densa. Perfusion with high sodium buffer (170 mM/l; osmolarity 350 mOs/l) induces a stimulation on renin release. However, a greater rise in renin is achieved in control experiments if choline chloride increases the osmolarity from 300 to 350 mOs/l. All this suggests that high sodium buffer, independently of its osmotic effect, has an inhibitory role on renin release.
mesh_terms: D000818:Animals; D007668:Kidney / Q000187:drug effects; D009994:Osmolar Concentration; D010477:Perfusion; D051381:Rats; D012083:Renin / Q000378:metabolism*; D012964:Sodium / Q000494:pharmacology*; D013268:Stimulation, Chemical; D000092502:Renin Inhibitors
chemical_list: D012083:Renin; D012964:Sodium; D000092502:Renin Inhibitors