[Prolongation of the mitotic life span of diploid human glia cells in a quantitative cell culture system by centrophenoxine (author's transl)].
The accumulation of lipofuscin in postmitotic and reversible postmitotic cells of animals and man is an age correlated process. The mechanism of the lipofuscin accumulation and the function of lipofuscin in the aging cell is not fully understood. The accumulation of lipofuscin in vivo and in vitro can be slowed down by the action of centrophenoxine (Helfergin). Diploid cells are the only reversible postmitotic cells of man that have a genetically determined limited cell division capacity and accumulate lipofuscin in the process of the cellular aging in a quantitative cell culture system in vitro. The treatment of diploid human glia cells with centrophenoxine results in increasing the cell division capacity by 30--40% in vitro. The data demonstrate that the centrophenoxine induced inhibition of lipofuscin accumulation has a positive influence on the cell metabolism and the mitotic division capacity and causes a delay of the cellular aging of the human glia cells in vitro.
D002478:Cells, Cultured; D004171:Diploidy; D005347:Fibroblasts / Q000187:drug effects; D006016:Glycolates / Q000494:pharmacology*; D006801:Humans; D008062:Lipofuscin / Q000378:metabolism; D002504:Meclofenoxate / Q000494:pharmacology*; D008938:Mitosis / Q000187:drug effects*; D009457:Neuroglia / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D013997:Time Factors
D006016:Glycolates; D008062:Lipofuscin; D002504:Meclofenoxate
Verlängerung der mitotischen Lebensspanne menschlicher Glia-Zellen in einem quantitativen Zellkultursystem durch Centrophenoxin.