Diabetes and cancer: a postulated relationship.
Diabetes leads to periodic fluctuations in levels of nutrients and cyclic nucleotides in plasma and various tissues. Variations in cyclic nucleotide levels, periods of nutrient elevation and surges of insulin combine to stimulate growth. Growth stimulation may be associated with the promotional phase of carcinogenesis. Diabetes should therefore predispose the individual to carcinogenesis and limited epidemiological data available suggest that it does.
D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D002453:Cell Cycle / Q000187:drug effects; D002642:Chick Embryo; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000378:metabolism; D006128:Growth; D006801:Humans; D007328:Insulin / Q000378:metabolism / Q000627:therapeutic use*; D051379:Mice; D008954:Models, Biological; D009369:Neoplasms / Q000209:etiology* / Q000378:metabolism; D009712:Nucleotides, Cyclic / Q000378:metabolism; D051381:Rats
D000596:Amino Acids; D007328:Insulin; D009712:Nucleotides, Cyclic