title: [Multivariate investigation of reactions to tranquilizers dependent on personality variables (author's transl)].
abstract: 5 mg of diazepam as well as 2.5, 5, and 10 mg of a substance from the thienodiazepine series (Bay g 5653) were compared with a placebo, following a double-blind procedure. The 149 male student volunteers were classified into introverts and extraverts. For 17 test variables including subjective and physiological measures, as well as psychomotoric and cognitive achievement variables, a 2 x 5-factorial MANOVA was computed. Effects of medication and of interactions between introversion/extraversion and medication were highly significant. Correlations of test variables with composite scores indicated that medication effects could be shown best with objective tests, while the interactions between introversion/extraversion and medication could be shown better with subjective variables. Results were discussed together with those of an earlier univariate analysis of the data using emotional stability/lability as a personality variable.
mesh_terms: D000328:Adult; D002986:Clinical Trials as Topic; D003071:Cognition / Q000187:drug effects; D003975:Diazepam / Q000494:pharmacology; D004311:Double-Blind Method; D005120:Extraversion, Psychological; D006801:Humans; D007439:Introversion, Psychological; D008297:Male; D009048:Motor Skills / Q000187:drug effects; D010551:Personality; D014149:Tranquilizing Agents / Q000494:pharmacology*
chemical_list: D014149:Tranquilizing Agents; D003975:Diazepam
vernacular_title: Multivariate Erfassung von Tranquilizerreaktionen in Abhängigkeit von Persönlichkeitsmerkmalen.