Relevance of polyclonal antibody formation to the development of autoimmunity : the model of African trypanosomiasis.
There is an induction of anti-DNA antibodies in mice following the administration of bacterial lipopolysaccharides, Dextran sulfate and PPD, which is closely associated with the property of these substances to trigger a polyclonal B cell activation. In the experiments model of African trypanosomiasis there is also an intense polyclonal antibody synthesis paralleled by the formation of several autoantibodies: anti-DNA, anti-bromelain treated mouse red blood cells and antithymocyte antibodies.
D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis*; D001402:B-Lymphocytes / Q000276:immunology; D002999:Clone Cells / Q000276:immunology; D004247:DNA / Q000096:biosynthesis; D003911:Dextrans / Q000494:pharmacology; D004195:Disease Models, Animal; D006462:Hemolytic Plaque Technique; D008070:Lipopolysaccharides / Q000494:pharmacology; D051379:Mice; D008809:Mice, Inbred C3H; D008819:Mice, Nude; D011070:Poly I-C / Q000494:pharmacology; D013601:T-Lymphocytes / Q000276:immunology; D014353:Trypanosomiasis, African / Q000276:immunology*; D014373:Tuberculin / Q000276:immunology
D001323:Autoantibodies; D003911:Dextrans; D008070:Lipopolysaccharides; D014373:Tuberculin; D004247:DNA; D011070:Poly I-C