Changes in pituitary gonadotropins during the amenorrhoea-galactorrhoea syndrome due to sulpiride.
Sulpiride, a dopamine receptor blocker which raises prolactin, was given to six women with idiopathic amenorrhoea for 10 days and to eleven women with regular cycles for 3 to 6 months. The latter group developed galactorrhoea and amenorrhoea during treatment. Basal LH AND FSH concentrations showed no significant changes. At 3 months but not at 10 days (amenorrhoea group) or 6 months (regular menses group) the area-under-the-curve of LH response to LHRH was increased. FSH responses to LHRH was not altered. The significance of these results to the hyperprolactinaemia-amenorrhoea syndromes are discussed.
D000568:Amenorrhea / Q000139:chemically induced*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D005687:Galactorrhea / Q000139:chemically induced*; D007987:Gonadotropin-Releasing Hormone; D006065:Gonadotropins, Pituitary / Q000097:blood*; D006801:Humans; D007775:Lactation Disorders / Q000139:chemically induced*; D007986:Luteinizing Hormone / Q000097:blood; D008598:Menstruation / Q000187:drug effects; D010902:Pituitary Gland / Q000187:drug effects; D011247:Pregnancy; D013469:Sulpiride / Q000494:pharmacology*; D013577:Syndrome
D006065:Gonadotropins, Pituitary; D007987:Gonadotropin-Releasing Hormone; D013469:Sulpiride; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone