Increased release of lymphokines by allografted mouse spleen cells following concanavalin A stimulation.
Using a test proposed in this laboratory for following macrophage "activation" (intracellular beta-glucuronidase content) and quantitative dilution studies, we have shown that lymphocytes from mice presensitized by a skin allograft release far more macrophage activating lympholines than do normal lymphocytes when non-specifically stimulated by concanavalin A. This difference may be due to latent metabolic changes of sensitized lymphocytes, but it may also express a modified balance among the various lymphocyte subpopulations within the spleen of grafted mice.
D000818:Animals; D003208:Concanavalin A / Q000276:immunology; D004791:Enzyme Inhibitors; D005966:Glucuronidase / Q000378:metabolism; D007114:Immunization; D008214:Lymphocytes / Q000276:immunology*; D008222:Lymphokines / Q000032:analysis*; D008264:Macrophages / Q000201:enzymology; D051379:Mice; D016038:Skin Transplantation; D013154:Spleen / Q000166:cytology; D014184:Transplantation, Homologous
D004791:Enzyme Inhibitors; D008222:Lymphokines; D003208:Concanavalin A; D005966:Glucuronidase