Erroneous thyroid-stimulating hormone radioimmunoassay results due to interfering antibovine thyroid-stimulating hormone antibodies.
Apparent elevation of serum thyroid-stimulating hormone (TSH) levels was found in a case of a patient receiving adequate replacement therapy after thyroidectomy for a follicular carcinoma. This was an artifact due to interference with the radioimmunoassay by circulating antibovine TSH antibodies. The double-antibody technic showed spuriously elevated levels, and the single-antibody technic showed low levels of serum TSH by radioimmunoassay in the presence of antibodies.
D000818:Animals; D000906:Antibodies; D002417:Cattle; D005260:Female; D006041:Goats; D006801:Humans; D007158:Immunologic Techniques; D007457:Iodine Radioisotopes; D008875:Middle Aged; D011817:Rabbits; D011863:Radioimmunoassay; D013972:Thyrotropin / Q000276:immunology*
D000906:Antibodies; D007457:Iodine Radioisotopes; D013972:Thyrotropin