Biphasic endotoxin fever in the newborn rabbit.
Rabbits aged 6-10 days responded to 20 or 50 microgram/kg i. p. or i. v. E. coli endotoxin with characteristic biphasic fever, whereas 0-3-day-old rabbits reacted with monophasic fever which coincided with the first-phase rise of the older group. In the rabbit, the mechanisms responsible for the first-phase and the second-phase febrile temperature rises appear separately in ontogenesis in the first week of extrauterine life.
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D004731:Endotoxins / Q000633:toxicity*; D004926:Escherichia coli; D005334:Fever / Q000209:etiology*; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D011817:Rabbits
D004731:Endotoxins