Effect of dexamethasone and testosterone propionate on LH response to gonadoliberin (LRH) in young post-pubertal bulls.
LH and testosterone responses to gonadoliberin (LRH) were studied after previous dexamethasone and testosterone propionate combined treatment (treated group) compared with a single dexamethasone previous treatment (control group) in 12 Montbéliarde bulls aged 15 months. This experiment was performed on two occaisions 6 months apart according to the same schedule. They included each time 6 bulls, treated with intramuscular injections of 400 mg testosterone propionate and 6 hours later 0.25 mg gonadoliberin together with the other 3 bulls. Testosterone propionate did not influence the mean LH response to gonadoliberin although mean testosterone levels before gonadoliberin injection was very low in the controls. These data suggest that (1) the previously reported depressing effect of dexamethasone on LH is not mediated by the low peripheral testosterone level and (2) under the conditions of this study, there is no short term effect of testosterone at the pituitary level.
D000818:Animals; D002417:Cattle; D003907:Dexamethasone / Q000494:pharmacology*; D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D013739:Testosterone / Q000097:blood / Q000494:pharmacology*
D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D003907:Dexamethasone; D007986:Luteinizing Hormone