Derivatives of side-chain hydroxylated nitrosamines direct acting mutagens in Salmonella typhimurium.
Methyl-(beta-tosyloxyethyl)nitrosamine and 3-methyl-4,5-dihydro-1,2,3-oxadiazolium tosylate are potent direct acting mutagens in the Ames assay, as is N-nitrosoprolinyl tosylate. These compounds are derived from beta-hydroxylated nitrosamines. The closely related methyl-(gamma-tosyloxypropyl)nitrosamine is not mutagenic without activation. These data are consistent with the chemical behavior of these substances, which suggest that suitable derivatives of beta-hydroxylated nitrosamines, such as O-sulfates, may be direct-acting biological alkylating agents.
D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005821:Genetic Techniques; D009153:Mutagens; D009602:Nitrosamines / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000235:genetics
D009153:Mutagens; D009602:Nitrosamines