title: The acquisition of antigens in the intercellular substance of mouse skin by schistosomula of Schistosoma mansoni.
abstract: Serum from patients suffering from the autoimmune skin disease pemphigus vulgaris has been used to demonstrate the presence of intercellular substance (ICS) on the surface of these chistosomula of Schistosoma mansoni which has penetrated mouse skin in vitro or during a percutaneous infection. ICS was absent from mechanically transformed schistosomula or those formed in the peritoneal cavity of mice. Schistosomula which penetrated mouse skin rapidly in vitro acquired very little of the ICS. It was found during a percutaneous infection that schistosomula recovered from the skin after 10 min had no detectable ICS, while those recovered after 2 hr and 24 hr gained increasing quantities of the material. It is concluded that schistosomula which are delayed in their exit from the skin acquire more ICS. However, this material must be shed during subsequent migration since schistosomula from lung and liver, and 7-week-old worms do not posses it. The implications of the findings are discussed.
mesh_terms: D000818:Animals; D000941:Antigens / Q000032:analysis*; D004817:Epidermis / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D006801:Humans; D051379:Mice; D010392:Pemphigus / Q000276:immunology; D012550:Schistosoma mansoni / Q000254:growth & development / Q000276:immunology*; D012552:Schistosomiasis / Q000469:parasitology; D012867:Skin / Q000469:parasitology; D012876:Skin Diseases, Parasitic / Q000469:parasitology; D013997:Time Factors
chemical_list: D000941:Antigens