Hypotensive response in spontaneously hypertensive rats following microinjection of alpha-methylnoradrenaline in the caudal brain-stem.
Local microinjection of 1.25 nmol (-)-alpha-methylnoradrenaline in the A2-region of the nucleus tractus solitarii (NTS) caused a decrease of blood pressure and heart rate in both spontaneous hypertensive rats (SHR) and Wistar-Kyoto (W/K) rats. Although the maximal responses in both strains did not differ, the decrease in blood pressure lasted longer in the SHR. These results do not support the concept of a diminished sensitivity of catecholaminergic receptors in the NTS of SHR to alpha-methylnoradrenaline.
D000818:Animals; D001794:Blood Pressure; D006339:Heart Rate; D006973:Hypertension / Q000503:physiopathology*; D008526:Medulla Oblongata / Q000503:physiopathology*; D008845:Microinjections; D009434:Neural Pathways / Q000503:physiopathology; D008771:Nordefrin / Q000008:administration & dosage; D009638:Norepinephrine / Q000031:analogs & derivatives*; D051381:Rats; D011919:Rats, Inbred Strains; D014630:Vagus Nerve / Q000503:physiopathology
D008771:Nordefrin; D009638:Norepinephrine