Prostaglandin regulation of colony-stimulating factor production by lipopolysaccharide-stimulated murine leukocytes.
The production of colony-stimulating factor by lipopolysaccharide-stimulated murine peritoneal leukocytes and their adherent subpopulations (greater than 80% macrophages) was markedly enhanced by indomethacin at concentrations sufficient to block prostaglandin E synthesis. Addition of physiological concentrations of E-series prostaglandins reversed this enhancing effect of indomethacin in a dose-dependent manner. These results indicate that colony-stimulating factor production by stimulated leukocytes is regulated by E-series prostaglandins and suggest that prostaglandins function to limit myelopoiesis by inhibiting colony-stimulating factor production and concomitantly the induction of cell proliferation.
D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology; D002478:Cells, Cultured; D003115:Colony-Stimulating Factors / Q000096:biosynthesis*; D004926:Escherichia coli / Q000276:immunology; D007213:Indomethacin / Q000494:pharmacology; D007962:Leukocytes / Q000276:immunology / Q000378:metabolism*; D008070:Lipopolysaccharides / Q000276:immunology*; D008264:Macrophages / Q000378:metabolism; D008297:Male; D051379:Mice; D011453:Prostaglandins / Q000494:pharmacology; D011458:Prostaglandins E / Q000502:physiology*
D003115:Colony-Stimulating Factors; D008070:Lipopolysaccharides; D011453:Prostaglandins; D011458:Prostaglandins E; D007213:Indomethacin