[Optically active barbiturates. Synthesis, configuration and pharmacological effects (author's transl)].
Optically active N-alkylated barbiturates are synthesized from disubstituted cyanoacetates. The configuration of the synthesized compounds is determined by chemical and chiroptical procedures and by X-ray analysis. In animals the barbiturates show a different anesthetic activity, in some cases the CNS activity is opposed, one enantiomer is anesthetically active, the other is a convulsive agent. In their pharmacokinetic behaviour the enantiomers show remarkable differences.
D000777:Anesthetics; D000818:Animals; D001463:Barbiturates / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D002490:Central Nervous System / Q000187:drug effects; D003292:Convulsants; D007700:Kinetics; D013053:Spectrophotometry; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014961:X-Ray Diffraction
D000777:Anesthetics; D001463:Barbiturates; D003292:Convulsants
Optisch aktive Barbituarte. Synthese, Konfiguration und pharmakologische Wirkung.