Possible modification of scar tissue by biochemical methods.
This paper reviews some of the biochemical modifications involved in fibrous tissue formation and discusses possible ways of controlling fibrosis in clinical conditions. The lathyritic agents, beta-aminoproprionitrile (BAPN) and penicillamine, appear in certain situations to be able to control fibrosis by blocking the biosynthesis of collagen. There are no compounds that are yet known which are capable of reversing pre-existing fibrosis and future research may perhaps be more profitably directed towards the stimulation of collagen catabolism rather than the inhibition of its synthesis.
D000629:Aminopropionitrile / Q000627:therapeutic use; D000818:Animals; D002921:Cicatrix / Q000378:metabolism / Q000517:prevention & control*; D003094:Collagen / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D003348:Cortisone / Q000627:therapeutic use; D006801:Humans; D006901:Hydroxylysine / Q000378:metabolism; D006909:Hydroxyproline / Q000378:metabolism; D008103:Liver Cirrhosis / Q000517:prevention & control; D010396:Penicillamine / Q000627:therapeutic use; D011347:Procollagen / Q000378:metabolism; D051381:Rats; D014945:Wound Healing
D011347:Procollagen; D000629:Aminopropionitrile; D006901:Hydroxylysine; D003094:Collagen; D010396:Penicillamine; D006909:Hydroxyproline; D003348:Cortisone