Lack of cytogenetic effects in mice or mutations in Salmonella receiving sodium fluoride.
We have examined the possible effect of fluoride intake on chromosome damage. There was no evidence of increased frequency of chromosomal aberration in bone marrow or testis cells of mice with either 50 ppm fluoride intake over several generations or 100 ppm intake for 6 weeks compared to animals drinking distilled water. Fluoride was not found to be mutagenic in a widely used bacterial mutagenesis assay over a range of 0.1 to as high as 2000 microgram fluoride per plate.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects; D004032:Diet; D004353:Drug Evaluation, Preclinical; D005459:Fluorides / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C / Q000235:genetics; D009153:Mutagens; D012486:Salmonella typhimurium / Q000187:drug effects; D012969:Sodium Fluoride / Q000494:pharmacology*; D013737:Testis / Q000187:drug effects
D009153:Mutagens; D012969:Sodium Fluoride; D005459:Fluorides