Single-dose therapy of falciparum malaria with mefloquine or pyrimethamine-sulfadoxine.
A single oral dose (1.5 g) of mefloquine hydrochloride cured all of 37 patients with falciparum malaria, and a single dose of pyrimethamine (75 mg) plus sulfadoxine (1.5 g) cured 34 of 38 patients. The rates at which parasitaemia and fever abated were similar for the two regimens but mefloquine was associated with a higher incidence of gastrointestinal side effects.
D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D006801:Humans; D008288:Malaria / Q000188:drug therapy*; D010880:Piperidines / Q000008:administration & dosage; D010963:Plasmodium falciparum; D011739:Pyrimethamine / Q000008:administration & dosage*; D011804:Quinolines / Q000008:administration & dosage*; D013413:Sulfadoxine / Q000008:administration & dosage*; D013424:Sulfanilamides / Q000008:administration & dosage*; D013607:Tablets
D010880:Piperidines; D011804:Quinolines; D013424:Sulfanilamides; D013607:Tablets; D013413:Sulfadoxine; D011739:Pyrimethamine