Cerebrospinal fluid dynamics in patients with pseudotumor cerebri.
CSF dynamics were determined as a function of intracranial pressure in patients with pseudotumor cerebri. Servocontrolled variable rate lumbar infusions were used to determine net CSF-absorptive capacities and resting pressures in 10 patients; serial studies were done in 5 of the patients. Nearly all of the patients had abnormally low CSF-absorptive capacities. On the other hand, marked elevations in resting pressure were not a constant feature of the disease. Concurrent changes in the cerebrovascular bed could introduce errors into this manometric determination of CSF dynamics; the significance of this potential artifact is examined. The results of this study suggest that the CSF compartment may be of etiological importance in the pathophysiology of pseudotumor cerebri.
D000293:Adolescent; D000328:Adult; D002560:Cerebrovascular Circulation; D002648:Child; D003936:Diagnosis, Computer-Assisted; D005260:Female; D006801:Humans; D006850:Hydrocephalus, Normal Pressure / Q000134:cerebrospinal fluid; D007427:Intracranial Pressure; D008297:Male; D008875:Middle Aged; D009862:Online Systems; D011559:Pseudotumor Cerebri / Q000134:cerebrospinal fluid* / Q000503:physiopathology