Prostacyclin: a potent activator of human colonic adenylate cyclase activity.
Prostacyclin and its stable catabolite 6-keto-prostaglandin F1 alpha were tested on the human colonic mucosal adenylate cyclase which represents the key enzyme in the secretory process in this organ. Prostacyclin was able to activate dose-dependently the human cyclase system. Saturating concentrations of prostacyclin and 6-keto-prostaglandin F1 alpha (each 0.28 mM) increased the enzyme activity 2.5-fold and only 1.4-fold, respectively. The presence of prostacyclin receptor sites in human colonic mucosa suggests a physiological role of this novel prostaglandin in human colonic function.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D003106:Colon / Q000201:enzymology*; D004789:Enzyme Activation / Q000187:drug effects; D011464:Epoprostenol / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000201:enzymology; D007651:Keto Acids / Q000494:pharmacology; D008297:Male; D011453:Prostaglandins / Q000494:pharmacology*; D011460:Prostaglandins F / Q000494:pharmacology; D011982:Receptors, Prostaglandin / Q000187:drug effects
D007651:Keto Acids; D011453:Prostaglandins; D011460:Prostaglandins F; D011982:Receptors, Prostaglandin; D011464:Epoprostenol; D000262:Adenylyl Cyclases