Immune interferon produced in vitro as a quantitative indicator of cell-mediated immunity.
The present study was constructed to provide some information on the possibility of utilizing immune interferon as a quantitative indicator of cell-mediated immunity and to clarify some of the nature of immune interferon-producing cells (IIPC). When spleen cells derived from L cell-sensitized mice were co-cultivated with L cells, interferon appeared in the culture fluid. It was shown by additional experiments that the cells responsible for immune interferon production in this system were T-lymphocytes assisted by macrophages. The pattern of kinetics of immune interferon production in vitro was similar to that of migration inhibitory factor or T cell-mediated cytotoxicity.
D000818:Animals; D003602:Cytotoxicity, Immunologic; D006968:Hypersensitivity, Delayed; D007111:Immunity, Cellular; D007372:Interferons / Q000096:biosynthesis*; D007739:L Cells; D007961:Leukocyte Migration-Inhibitory Factors / Q000096:biosynthesis; D008264:Macrophages / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism
D007961:Leukocyte Migration-Inhibitory Factors; D007372:Interferons