Ascending infection following cervicovaginal exposure to herpesvirus hominis type II.
An animal model is presented that demonstrates that following cervicovaginal inoculation, infective doses of herpesvirus hominis type II induce a form of herpetic encephalitis. Immunofluorescent results indicate that there is both neural and hematogenous spread of the herpes infection. The possible role of a latent viral infection in the genesis of an acute disease of the central nervous system is investigated in this experimental system.
D000818:Animals; D002540:Cerebral Cortex / Q000473:pathology; D002584:Cervix Uteri / Q000382:microbiology*; D004195:Disease Models, Animal; D004660:Encephalitis / Q000382:microbiology / Q000473:pathology / Q000635:transmission*; D005260:Female; D005455:Fluorescent Antibody Technique; D006561:Herpes Simplex / Q000382:microbiology / Q000473:pathology / Q000635:transmission*; D051381:Rats; D014621:Vagina / Q000382:microbiology*