Neurotoxicities of current leukemia therapy.
While major advances have been made in the treatment of acute leukemia, complications of therapy are significant. One of the most worisome complications is the neurotoxicity which is related to both central nervous system prophylaxis (cranial irradiatif neurotoxicity may be acute or delayed, and may range in severity from mild headaches ann of treatment-related neurotoxicity is important since this may permit amelioration of otherwise irreversible neurological sequelae in some patients. We review the clinical, phyh irradiation and chemotherapy, and offer recommendations for monitoring, evaluating and treating patients with potential or proven neurotoxicity.
D000970:Antineoplastic Agents / Q000009:adverse effects*; D001853:Bone Marrow / Q000187:drug effects / Q000528:radiation effects; D001927:Brain Diseases / Q000175:diagnosis / Q000209:etiology*; D002493:Central Nervous System Diseases / Q000517:prevention & control; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007275:Injections, Intravenous; D007278:Injections, Spinal / Q000009:adverse effects; D007938:Leukemia / Q000188:drug therapy*; D007945:Leukemia, Lymphoid / Q000532:radiotherapy; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects / Q000134:cerebrospinal fluid / Q000627:therapeutic use; D009420:Nervous System / Q000187:drug effects / Q000528:radiation effects; D011832:Radiation Injuries / Q000175:diagnosis*; D011878:Radiotherapy / Q000009:adverse effects*; D013129:Spinal Puncture / Q000009:adverse effects
D000970:Antineoplastic Agents; D008727:Methotrexate