Enhancement of deoxyribonucleic acid polymerase I-directed repair synthesis in toluene-treated Escherichia coli after growth in the presence of low levels of N-methyl-N'-nitro-N-nitrosoguanidine.
Deoxyribonucleic acid polymerase I-directed repair synthesis can be selectively measured in toluene-treated Escherichia coli cells exposed to alkylating chemicals such as N-methyl-N'-nitro-N-nitrosoguanidine. Prior growth of the cells in the presence of a low dose of N-methyl-N'-nitro-N-nitrosoguanidine results in an enhanced deoxyribonucleic acid polymerase I-directed repair synthesis and an increase in single-strand breaks.
D004256:DNA Polymerase I / Q000378:metabolism*; D004260:DNA Repair / Q000187:drug effects*; D004269:DNA, Bacterial / Q000096:biosynthesis*; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism*; D004926:Escherichia coli / Q000187:drug effects* / Q000378:metabolism; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology*; D014050:Toluene / Q000494:pharmacology
D004269:DNA, Bacterial; D008769:Methylnitronitrosoguanidine; D014050:Toluene; D004256:DNA Polymerase I; D004259:DNA-Directed DNA Polymerase