Functional and morphological recovery of the T-cell compartment in lethally irradiated and reconstituted mice.
The recovery of the T-cell compartment in mice after lethal irradiation and reconstitution was studied using functional and morphological parameters. T-helper cell activity, determined by the direct SRBC-plaque-forming cell (PFC) response, recovers in a similar fashion as T-memory function which was studied by adoptive transfer of carrier-primed cells. Both functions return to control levels in 2.5-3 months. Using immunoperoxidase staining of frozen sections with anti-T cell serum, the morphological recovery of the T-cell dependent areas in the white pulp of the spleen could be studied and compared with the functional recovery.
D000818:Animals; D000961:Antilymphocyte Serum; D006462:Hemolytic Plaque Technique; D007116:Immunization, Passive; D007124:Immunoenzyme Techniques; D007156:Immunologic Memory; D051379:Mice; D013154:Spleen / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology* / Q000473:pathology / Q000528:radiation effects
D000961:Antilymphocyte Serum