Effects in bacterial systems of Pt(II) complexes with antitumour activity.
A series of alicyclic amine complexes of the cis-Pt(am)2Cl2 type, showed specific antitumour activity against various animal tumours. We have tested these compounds in a number of bacterial systems indicative of their interaction with bacterial DNA.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002945:Cisplatin / Q000494:pharmacology*; D003503:Cyclobutanes / Q000494:pharmacology; D003514:Cyclohexylamines / Q000494:pharmacology; D003517:Cyclopentanes / Q000494:pharmacology; D004260:DNA Repair / Q000187:drug effects*; D004269:DNA, Bacterial / Q000378:metabolism*; D004353:Drug Evaluation, Preclinical; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics; D007939:Leukemia L1210 / Q000188:drug therapy; D009153:Mutagens; D010954:Plasmacytoma / Q000188:drug therapy; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000235:genetics; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D003503:Cyclobutanes; D003514:Cyclohexylamines; D003517:Cyclopentanes; D004269:DNA, Bacterial; D009153:Mutagens; D002945:Cisplatin