[Reactogenicity and immunological effectiveness of an oral cholera chemical vaccine in a limited controlled experiment with human revaccination].
Oral cholera chemical vaccine in the doses tested (2 and 3 tablets) proved to be areactogenic, harmless and immunologically effective in a controlled limited trial in 150 volunteers. By the results of titration of specific antitoxins and vibriocidal antibodies in the blood serum, as well as of coproantibodies a dose of 2 tablets was chosen as the optimal one.
D000284:Administration, Oral; D000328:Adult; D000907:Antibodies, Bacterial / Q000096:biosynthesis*; D000992:Antitoxins / Q000032:analysis; D022121:Cholera Vaccines / Q000008:administration & dosage / Q000276:immunology*; D002986:Clinical Trials as Topic; D004306:Dose-Response Relationship, Immunologic; D004341:Drug Evaluation; D006801:Humans; D007117:Immunization, Secondary; D007277:Injections, Jet; D013607:Tablets; D013997:Time Factors; D014121:Toxoids / Q000276:immunology; D014611:Vaccination; D014734:Vibrio cholerae / Q000276:immunology*
D000907:Antibodies, Bacterial; D000992:Antitoxins; D022121:Cholera Vaccines; D013607:Tablets; D014121:Toxoids
Reaktogennost' i immunologicheskaia éffektinost' oral'noĭ kholernoĭ khimicheskoĭ vaktsiny v ogranichennom kontroliruemom opyte revaktsinatsii liudeĭ.