[Recipient conditioning with beagle plasma and beagle liver: prolongation of kidney-graft function without preoperative lymphocytotoxic antibody formation].
Donorspecific recipient conditioning in the non-related beagle produces prolonged kidney-graft survival without any postoperative immunosuppression. Besides 2 donor blood injections on days--18 and--11 followed by a 6-day preoperative immunosuppressive pulse (Procarbazine, ATS) donor plasma and a donor liver preparation are equally active. Additional long-term low dose preoperative immunosuppression with azathioprine tends to strengthen the effect. Lymphocytotoxic antibody formation is avoided in the recipient where no whole blood is used.
D000818:Animals; D001379:Azathioprine / Q000627:therapeutic use; D001803:Blood Transfusion; D004285:Dogs; D006084:Graft Rejection; D006085:Graft Survival; D006649:Histocompatibility Antigens / Q000008:administration & dosage; D007165:Immunosuppression Therapy / Q000379:methods*; D007166:Immunosuppressive Agents; D016030:Kidney Transplantation; D008099:Liver / Q000276:immunology; D016031:Liver Transplantation; D011344:Procarbazine / Q000627:therapeutic use; D014184:Transplantation, Homologous
D006649:Histocompatibility Antigens; D007166:Immunosuppressive Agents; D011344:Procarbazine; D001379:Azathioprine
Empfängerkonditionierung mit Spenderplasma und Spenderleber: Verlängerung der Nierentransplantatfunktion ohne präoperative Bildung lymphozytotoxischer Antikörper.