Inosine: clinical results of ischaemic renal surgery.
Ten patients requiring ischaemic renal surgery for calculus or tumour were operated on with the kidney protected by perfusion with a room temperature solution of inosine. The warm ischaemic times ranged from 35 to 75 min (mean 57.1 min). Post-operative recovery was uneventful in all patients. No adverse cardiodynamic effects due to inosine were noted. There was only moderate transient depression in renal function as assessed by gamma camera renography and serum creatinine estimations. Three of the 10 patients have now been followed for over a year. The results with inosine perfusion are comparable to those obtained with hypothermic protection.
D000328:Adult; D000368:Aged; D000818:Animals; D002986:Clinical Trials as Topic; D003404:Creatinine / Q000097:blood; D004285:Dogs; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007288:Inosine / Q000627:therapeutic use*; D007511:Ischemia; D007668:Kidney / Q000098:blood supply*; D007669:Kidney Calculi / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011866:Radioisotope Renography
D007288:Inosine; D003404:Creatinine