title: [Nature of the intermediate compound formed during catalysis by pepsin].
abstract: The applicability of the free energies linearity principle to catalysis by pepsin may indicate that the mechanism of formation of a covalent pepsin intermediate with the second (amine or alcohol) part of the hydrolyzed substrate is a true one. The choice has been made from consideration of three possible types of mechanisms covalent binding, complex with a nonionized NH2-group and the absence of an activated intermediate.
mesh_terms: D004789:Enzyme Activation; D007700:Kinetics; D008433:Mathematics; D010434:Pepsin A / Q000378:metabolism*; D011485:Protein Binding; D013816:Thermodynamics
chemical_list: D010434:Pepsin A
vernacular_title: O prirode promezhutochnogo soedineniia v pepsinovom katalize.