title: Ultrastructural study of normal and leukaemic leucocyte processes.
abstract: Cellular processes of leucocytes from both normal and leukaemic subjects were studied at the ultrastructural level. By high voltage transmission electron microscopy without a metal coating, more surface features could be seen in the cells than were observed by either scanning electron microscopy or conventional transmission electron microscopy. The technique was shown to be especially useful as it allows direct visualisation of the cell surface structure at high resolution without artefact-inducing preparative processes. Demonstrating receptor sites with this technique opens up the possibility of studying lymphocyte microvilli in greater detail.
mesh_terms: D001665:Binding Sites; D002462:Cell Membrane / Q000648:ultrastructure; D006801:Humans; D007124:Immunoenzyme Techniques; D007938:Leukemia / Q000097:blood*; D007962:Leukocytes / Q000648:ultrastructure*; D008854:Microscopy, Electron