[Immunodepressive action of carminomycin and rubomycin derivatives].
The immunodepressive effects of carminomycin and its 3 semi-synthetic derivatives, as well as rubomycin and its derivative R-103 were compared. It was found that 14-hydroxycarminomycin was much superior to the other substances in the experiments with synthesis induction suppression of antibodies against sheep red cells in mice. Suppression of the rejection of the skin allogenic grafts in the mice by carminomycin was higher as compared to that by the other substances. Probably different populations of the immune competent cells have selective sensitivity to separate anthracyclines.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000276:immunology*; D000917:Antibody Formation / Q000187:drug effects; D002360:Carubicin / Q000031:analogs & derivatives / Q000276:immunology*; D003630:Daunorubicin / Q000031:analogs & derivatives* / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D007109:Immunity / Q000187:drug effects; D007166:Immunosuppressive Agents; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D016038:Skin Transplantation; D014181:Transplantation Immunology / Q000187:drug effects; D014184:Transplantation, Homologous
D000903:Antibiotics, Antineoplastic; D007166:Immunosuppressive Agents; D002360:Carubicin; D003630:Daunorubicin
Immunodepressivnoe deĭstvie proizvodnykh karminomitsina i rubomitsina.