title: Research related to validation of treatment modalities by large-scale clinical trials.
abstract: The history of randomized, controlled, clinical trials is reviewed. Cooperative clinical trials are reviewed and summarized, and specific needs for future trials are identified. Improved policy on resource allocation decisions for clinical trials vs other forms of research is necessary, particularly as such trials begin to translate improved therapeutic knowledge into community level disease control.
mesh_terms: D000572:American Heart Association / Q000266:history; D001161:Arteriosclerosis / Q000628:therapy; D002986:Clinical Trials as Topic / Q000266:history / Q000379:methods*; D049673:History, 20th Century; D006801:Humans; D006973:Hypertension / Q000628:therapy; D009316:National Institutes of Health (U.S.) / Q000266:history; D012106:Research / Q000266:history; D012306:Risk; D014481:United States