The role of prostaglandins in platelet-vessel wall interaction.
Flurbiprofen, a cyclooxygenase inhibitor, and tranylcypromine, a PGI2 synthetase inhibitor, in topical superfusion over an arterial segment respectively decrease and increase ADP-induced local white platelet thrombus formation. Superfusion of the arterial segment with PGI2 demonstrates a dose-response related inhibition of ADP-induced thrombosis.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D001792:Blood Platelets / Q000502:physiology*; D001808:Blood Vessels / Q000502:physiology*; D011464:Epoprostenol / Q000494:pharmacology; D005480:Flurbiprofen / Q000494:pharmacology; D066298:In Vitro Techniques; D008861:Microsomes / Q000378:metabolism; D011453:Prostaglandins / Q000502:physiology*; D051381:Rats; D014191:Tranylcypromine / Q000494:pharmacology
D011453:Prostaglandins; D014191:Tranylcypromine; D005480:Flurbiprofen; D000244:Adenosine Diphosphate; D011464:Epoprostenol