Activation of peritoneal macrophages by oil-attached cell-wall skeleton of BCG and Nocardia rubra.
The effect of oil-attached cell-wall skeletons of BCG (BCG-CWS) and Nocardia rubra (N. rubra-CWS) on macrophage functions was examined regarding phagocytosis of zymosan particles, uptake of 2-deoxy-D-glucose (2-dG), and cytostatic activity against syngeneic tumor cells. A single intraperitoneal injection of either BCG-CWS or N. rubra-CWS in mice resulted in accumulation of a large number of macrophages in the peritoneal cavity. They demonstrated, in vitro, a significant cytostatic effect on target cells as well as increase in phagocytic activity and uptake of 2-dG. These results suggest that one of underlying mechanisms for the antitumor activity of BCG-CWS and N. rubra-CWS is possibly the activated macrophage-mediated system.
D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology / Q000276:immunology; D001500:BCG Vaccine / Q000494:pharmacology* / Q000627:therapeutic use; D001428:Bacterial Vaccines / Q000494:pharmacology* / Q000627:therapeutic use; D002473:Cell Wall; D005260:Female; D008264:Macrophages / Q000276:immunology / Q000502:physiology*; D051379:Mice; D008809:Mice, Inbred C3H; D009163:Mycobacterium bovis / Q000648:ultrastructure; D009374:Neoplasms, Experimental / Q000628:therapy; D009615:Nocardia / Q000648:ultrastructure; D010954:Plasmacytoma / Q000628:therapy
D001500:BCG Vaccine; D001428:Bacterial Vaccines