title: [Genetic effects of N-nitroso-N-methylurea on Saccharomyces cerevisiae yeasts. I. The influence of radiosensitivity mutations on lethal and recombinogenic effects].
abstract: Effect of mutations rad2 and rad54 in homozygous state on survival, mitotic segregation and crossing-over induced by NMU in yeast was studied. Mutation rad2 did not influence on these effects of NMU. The mutation rad54 increased sensitivity to the lethal effect, the frequencies of NMU-induced segregation and crossing-over were decreased in the strain rad54 rad54. The recombinogenic effect of NMU on yeast was lower than under the action of UV and gamma rays.
mesh_terms: D003434:Crossing Over, Genetic / Q000187:drug effects; D004171:Diploidy; D005804:Genes, Lethal / Q000187:drug effects; D006238:Haploidy; D008770:Methylnitrosourea / Q000494:pharmacology*; D008938:Mitosis / Q000187:drug effects; D009154:Mutation; D009607:Nitrosourea Compounds / Q000494:pharmacology*; D011836:Radiation Tolerance; D011995:Recombination, Genetic / Q000187:drug effects; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000235:genetics* / Q000528:radiation effects
chemical_list: D009607:Nitrosourea Compounds; D008770:Methylnitrosourea
vernacular_title: Izuchenie geneticheskikh éffektov N-nitrozo-N-metilmocheviny na drozhzhi Saccharomyces cerevisiae. Soobshchenie I. Vliianie mutatsiĭ radiochuvstvitel'nosti na letal'nyĭ i rekombinagennyĭ éffekty.