Effect of ethanol on membranes: a fluorescent probe study.
Using fluorescence techniques to study changes in membrane structure as a function of ethanol concentration and alcoholism, it was found that ethanol primarily affects probes located at the membrane-water interface. Changes in the lipid composition of membranes during alcoholism were detected by fluorescent probes that partition into the hydrophobic interior of the membrane.
D000437:Alcoholism / Q000503:physiopathology; D000777:Anesthetics / Q000494:pharmacology; D002784:Cholesterol / Q000378:metabolism; D004910:Erythrocyte Membrane / Q000187:drug effects; D000431:Ethanol / Q000494:pharmacology*; D005453:Fluorescence; D006801:Humans; D066298:In Vitro Techniques; D008563:Membrane Lipids / Q000378:metabolism; D008566:Membranes / Q000187:drug effects*; D010743:Phospholipids / Q000378:metabolism
D000777:Anesthetics; D008563:Membrane Lipids; D010743:Phospholipids; D000431:Ethanol; D002784:Cholesterol