title: [Levamisol in the treatment of recurrent urinary tract infections].
abstract: Levamisole, a widely used antihelminthic drug, possesses immunotropic properties. It has been proved that children with recurrent infections of the respiratory tract who were given the drug, were capable of preventing the repetition of the infections. Twenty-seven (27) children with recurrent urinary tract infections without structural malformations were studied and in all of them, a diminished cellular immunity was detected (blastic transformation of lymphocytes, rosettes of T lymphocytes and the skin tests). The drug was administered in doses of 2.5 mg/k/day, twice a week, for eight months. During the period of study, in 21 children repetition of the infections were not detected and in 13, a significant improvement of the cellular immunity was achieved. In some children it was possible to prove a rise of the IgA secretary in the urine.
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects*; D007978:Levamisole / Q000494:pharmacology / Q000627:therapeutic use*; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D012008:Recurrence; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000187:drug effects; D014552:Urinary Tract Infections / Q000188:drug therapy*
chemical_list: D007978:Levamisole
vernacular_title: Levamisol en el tratamiento de las infecciones urinarias recurrentes.