[Immunosuppression, bone marrow infusion and low dose androgens, successful therapy of severe aplastic anemia].
18 patients with severe aplastic anemia (SAA) but without an HLA-identical sibling were treated by antilymphocyte globulin (ALG) followed by infusion of marrow cells from a semi-compatible family donor. 13 of these received low dose androgens after ALG: 11 (85%) achieved stable remission without transfusion requirement. One patient relapsed after 4 months, one patient with only partial remission died from infection. None of the 4 patients who did not receive androgens after ALG achieved remission. ALG, marrow and low-dose androgens represent a promising therapy for SAA and can be favorably compared with allogeneic bone marrow transplantation.
D000293:Adolescent; D000328:Adult; D000741:Anemia, Aplastic / Q000628:therapy*; D000961:Antilymphocyte Serum / Q000627:therapeutic use*; D016026:Bone Marrow Transplantation; D006648:Histocompatibility; D006801:Humans; D007165:Immunosuppression Therapy; D008875:Middle Aged; D009639:Norethandrolone / Q000627:therapeutic use; D010110:Oxymetholone / Q000627:therapeutic use
D000961:Antilymphocyte Serum; D010110:Oxymetholone; D009639:Norethandrolone
Immunosupression, Knochenmarkinfusion und niedrig dosierte Androgene, eine erfolgreiche Therapie der schweren aplastischen Anämie.