A family with allo-immune neonatal neutropenia: group-specific pathogenicity of maternal antibodies.
A family is presented, in which the mother developed strong neutrophil granulocyte-specific antibodies with the specificity anti-NA. The first and third children, both NA1-positive, suffered from severe transient neonatal neutropenia, but the second child, NA1-negative, did not. Anti-NA1 antibodies were detectable in the serum of one affected child and the antibody level was directly related to the extent of neutropenia. The incidence of granulocyte-specific antibodies in 198 pregnant women was determined and found to be low.
D000380:Agranulocytosis / Q000276:immunology*; D000918:Antibody Specificity; D001789:Blood Group Antigens; D005260:Female; D005455:Fluorescent Antibody Technique; D006098:Granulocytes / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000276:immunology*; D007518:Isoantibodies; D007958:Leukocyte Count; D008297:Male; D009503:Neutropenia / Q000276:immunology*; D009504:Neutrophils; D010375:Pedigree; D011247:Pregnancy
D001789:Blood Group Antigens; D007074:Immunoglobulin G; D007518:Isoantibodies