[Orthotopic liver transplantation in rats. Prolonging of survival time of allotransplants using cyclosporin A in an acute rejection model].
Livers from inbred DA rats were transplanted orthotopically into inbred BN rats. Within 15 days all animals died due to rejection of the transplant. However, when rats were treated with Cyclosporin A (four different regimens) they survived for at least 60 days, even if therapy was withdrawn at day 28. It could be shown that the histologic changes in the graft stood in an inverse relationship to the extent of immunosuppressive therapy.
D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001663:Bilirubin / Q000097:blood; D001835:Body Weight; D004195:Disease Models, Animal; D006084:Graft Rejection / Q000187:drug effects*; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D008099:Liver / Q000378:metabolism / Q000473:pathology; D016031:Liver Transplantation; D008297:Male; D010456:Peptides, Cyclic / Q000008:administration & dosage*; D051381:Rats; D011914:Rats, Inbred BN; D011919:Rats, Inbred Strains; D014184:Transplantation, Homologous
D007166:Immunosuppressive Agents; D010456:Peptides, Cyclic; D000469:Alkaline Phosphatase; D001663:Bilirubin
Orthotope Lebertransplantation bei der Ratte. Verlängerung der Uberlebenszeit von Allotransplantaten durch Cyclosporin A in einem starken Abstossungsmodell.