Insulin receptors in human mononuclear leucocytes. I. Binding and degradation of insulin in normal subjects.
The binding and degradation of 125I-Insulin were investigated in mononuclear leukocytes of normal subjects. The binding data analysis show that the insulin degradation is strictly correlated with the binding of the hormone to its receptors: these data suggest that the binding of insulin to specific receptor is the possible first step for its degradation.
D000328:Adult; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D007962:Leukocytes / Q000378:metabolism*; D011972:Receptor, Insulin / Q000378:metabolism*
D007328:Insulin; D011972:Receptor, Insulin