title: Cancer of endocrine glands and target organs: genetic considerations.
abstract: The pathogenesis of cancer in general is influenced by many factors, genetic and environmental. Epidemiological studies demonstrate familial aggregation of cancer in a significant proportion of cases. Many of these familial cancer syndromes contain endocrine hormone-related components. The etiology of endocrine-related cancers is complex, as is that of other cancers. Tumors of endocrine glands and target organs are subject to the same influences as other cancers; an additional variable is that of hormone-responsiveness.
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000235:genetics; D001943:Breast Neoplasms / Q000235:genetics; D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D005260:Female; D006801:Humans; D008297:Male; D010051:Ovarian Neoplasms / Q000235:genetics; D010190:Pancreatic Neoplasms / Q000235:genetics; D009384:Paraneoplastic Endocrine Syndromes / Q000235:genetics*; D010911:Pituitary Neoplasms / Q000235:genetics; D013736:Testicular Neoplasms / Q000235:genetics; D013964:Thyroid Neoplasms / Q000235:genetics; D014594:Uterine Neoplasms / Q000235:genetics