The relationship between disturbed metabolism of vitamin D and bone disease in chronic renal failure.
Following the discovery that the kidney is involved in the metabolism of vitamin D, a causal relationship has been sought between defective production of 1,25-dihydroxy vitamin D3 and bone disease in chronic renal failure. This paper reviews some of the clinical evidence for and against such a relationship, and considers the possible role of other vitamin D metabolites in the pathophysiology of renal bone disease.
D001847:Bone Diseases / Q000150:complications*; D007668:Kidney / Q000201:enzymology; D007676:Kidney Failure, Chronic / Q000150:complications*; D008099:Liver / Q000378:metabolism; D010018:Osteomalacia / Q000209:etiology; D010710:Phosphates / Q000097:blood; D014807:Vitamin D / Q000096:biosynthesis / Q000378:metabolism*
D010710:Phosphates; D014807:Vitamin D