Lymphokine-supressing cells in patients after kidney transplantation.
Streptococcal antigens elicit Leukocyte Migration Inhibitory Factor (LMIF) production by sensitive human lymphocytes in vitro leading to an inhibition of leukocyte migration in agarose plates. When mononuclear cells isolated from peripheral blood of healthy donors are added to the assay system, no significant alteration of LMIF generation occurs. Likewise, cells from patients with kidney allografts obtained during an uneventful postoperative course did not influence lymphokine synthesis. Conversely, cells isolated from patients undergoing acute graft rejection abolished SKSD-induced LMIF production by normal lymphocytes. These results support our earlier report of the existence of lymphokine-suppressing cells in man and suggest that they may play yet poorly defined role in certain immunopathologic situations.
D006084:Graft Rejection; D006801:Humans; D007165:Immunosuppression Therapy; D016030:Kidney Transplantation; D008222:Lymphokines / Q000096:biosynthesis*; D009000:Monocytes / Q000276:immunology; D014184:Transplantation, Homologous
D008222:Lymphokines