Anti-idiotypic antibodies induce formation of anti-H-2 sera and of idiotypes.
Alloantisera could be induced in parental strain recipients either by means of alloantigen (skin allografting) or by injecting anti-idiotypic (anti-T cell receptor) sera. The resulting sera displayed activity against H-2 antigens; they also contained soluble isiotypic structures. With these sera anti-idiotypic sera could be provoked in F1 hybrid hosts. If antibody cycles initiated with alloantigen were carried through four runs, specificity appeared to be preserved and titers obtained corresponded to those found in conventionally raised anti-idiotypic sera and in alloantisera.
D000818:Animals; D000906:Antibodies / Q000008:administration & dosage*; D006183:H-2 Antigens / Q000008:administration & dosage / Q000276:immunology*; D006824:Hybridization, Genetic; D007518:Isoantibodies / Q000096:biosynthesis*; D051379:Mice; D008815:Mice, Inbred Strains; D016038:Skin Transplantation; D013601:T-Lymphocytes / Q000276:immunology; D014184:Transplantation, Homologous
D000906:Antibodies; D006183:H-2 Antigens; D007518:Isoantibodies