Creatine kinase MB isoenzyme in the evaluation of myocardial infarction.
The measurement of serum CK-MB isoenzyme is a very sensitive and specific indication of myocardial injury since only myocardium has substantial amounts of CK-MB. Serum CK-MB levels are most helpful clinically when the total creatine kinase is nonspecifically elevated, as with intramuscular injections, cardiac catheterization, stroke, noncardiac surgery and electric cardioversion. Elevations of serum CK-MB occurring in Duchenne's muscular dystrophy and other neuromuscular disorders may be due to the presence of abnormal regenerative skeletal muscle fibers, which are known to contain large amounts of CK-MB isoenzyme. These examples emphasize that under normal, nonregenerative conditions, elevations of serum CK-MB are rare in the absence of myocardial injury.
D000818:Animals; D002845:Chromatography; D004796:Clinical Enzyme Tests; D003402:Creatine Kinase / Q000097:blood*; D004586:Electrophoresis; D005188:False Negative Reactions; D005189:False Positive Reactions; D006801:Humans; D007527:Isoenzymes; D008722:Methods; D009132:Muscles / Q000201:enzymology; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology; D011863:Radioimmunoassay; D012016:Reference Values
D007527:Isoenzymes; D003402:Creatine Kinase