Antifungal activity of transferrin.
Inhibitory effects of transferrin on fungal growth were successfully estimated by measuring fungal ATP content. By this method, it was demonstrated that both human and rabbit transferrin possessed the inhibitory effect in the absence of any other factor on yeast-like and filamentous fungi. However, rabbit stimulation factor enhanced the inhibitory effect. The inhibitory effect of transferrin was nonspecific and correlated with unsaturated iron binding capacity (UIBC) of transferrin. Human transferrin was more inhibitory than rabbit transferrin.
D000818:Animals; D000935:Antifungal Agents; D002175:Candida / Q000254:growth & development; D002176:Candida albicans / Q000254:growth & development; D003455:Cryptococcus neoformans / Q000254:growth & development; D005658:Fungi / Q000187:drug effects / Q000254:growth & development*; D006801:Humans; D008864:Microsporum / Q000254:growth & development; D011817:Rabbits; D013045:Species Specificity; D014168:Transferrin / Q000494:pharmacology*; D014249:Trichophyton / Q000254:growth & development
D000935:Antifungal Agents; D014168:Transferrin