title: [Mechanism of action of serum globulin preparations].
abstract: Experiments on mice demonstrated that serum homologous globulin preparations containing normal autoantibodies caused induction of autoantibodies in subcutaneous injection to intact animals; this was recorded on the basis of increase of the blood autoantibody level and of the plaque-forming cells content in the spleen tissue. This activation was seen as soon as the first hours--24 hours after the administration of the preparation and failed to disappear in 7 days, persisting in repeated administration of the preparation.
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D001323:Autoantibodies / Q000032:analysis; D004306:Dose-Response Relationship, Immunologic; D007112:Immunity, Maternally-Acquired / Q000187:drug effects; D007158:Immunologic Techniques; D008297:Male; D051379:Mice; D012397:Rosette Formation; D012712:Serum Globulins / Q000276:immunology*; D013997:Time Factors
chemical_list: D001323:Autoantibodies; D012712:Serum Globulins
vernacular_title: O mekhanizme deĭstviia preparatov syvorotochnykh globulinov.