title: [Bacteriological in vitro investigations with cefaclor. Correlation of inhibition zone diameter and minimal inhibitory concentration (author's transl)].
abstract: A comparison of the minimal inhibitory concentrations (MIC) of cefaclor and cephalexin shows that cefaclor is noticeably superior against Citrobacter. Enterobacter and Proteus mirabilis. Only slight differences are seen against other enterobacteria and Staphylococcus aureus. Both cefaclor and cephalexin are completely ineffective against enterococci and Pseudomonas aeruginosa. Regression analysis to correlate the inhibition zone diameter and MIC of cefaclor produced a very good correlation (r = -0.9741). Using 30 mcg discs on DST agar, inhibition zones of more than 20 mm are to be interpreted as "sensitivity" and zones of less than 13 mm as "resistance".
mesh_terms: D001419:Bacteria / Q000187:drug effects*; D002433:Cefaclor / Q000494:pharmacology*; D002506:Cephalexin / Q000031:analogs & derivatives* / Q000494:pharmacology; D002954:Citrobacter / Q000187:drug effects; D004352:Drug Resistance, Microbial; D004754:Enterobacter / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011513:Proteus mirabilis / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D002433:Cefaclor; D002506:Cephalexin
vernacular_title: Bakteriologische in-vitro-Untersuchungen mit Cefaclor. Korrelation von Hemmhofdurchmesser und minimaler Hemmkonzentration.