A quantitative comparison of whole antibody and F(ab')2 in kidney allograft enhancement.
Whole antiserum, IgG, and a greater than 99% pure F(ab')2 preparation were compared for their ability to enhance Lewis renal allografts in DA recipients. Despite having unimpaired antigen-binding capacity, the DA anti-Lewis F(ab')2 was virtually ineffective at the highest dose tested, and was calculated to be a minimum of 100 times less effective than whole antibody. The administration of a 10-fold excess of F(ab')2 before an effective dose of IgG did not block the enhancing effect of the latter.
D000818:Animals; D000906:Antibodies / Q000276:immunology*; D000917:Antibody Formation; D003601:Cytotoxicity Tests, Immunologic; D006085:Graft Survival; D007106:Immune Sera / Q000494:pharmacology; D007140:Immunoglobulin Fab Fragments / Q000276:immunology*; D007668:Kidney / Q000473:pathology; D016030:Kidney Transplantation; D051381:Rats; D011917:Rats, Inbred Lew; D014184:Transplantation, Homologous
D000906:Antibodies; D007106:Immune Sera; D007140:Immunoglobulin Fab Fragments