Alternative pathway of complement activation by Candida albicans.
Activation of the alternative pathway of complement by Candida albicans was examined using a chemotactic assay. Two serologically defined strains and eight clinical isolates of Candida albicans were used in these experiments. The results showed that all ten strains of Candida albicans were capable of alternative complement pathway activation. These findings may provide an insight into host resistance to this infection.
D002176:Candida albicans / Q000276:immunology*; D002634:Chemotaxis, Leukocyte; D003167:Complement Activation; D003175:Complement C2 / Q000172:deficiency; D003176:Complement C3 / Q000096:biosynthesis; D003182:Complement C5 / Q000096:biosynthesis; D003170:Complement Pathway, Alternative; D046508:Culture Techniques; D006801:Humans; D009504:Neutrophils / Q000276:immunology
D003175:Complement C2; D003176:Complement C3; D003182:Complement C5