[Influence of the age of the recipient on the manifestation of the effect of allogeneic inhibition].
The expression of allogenic inhibition was studied when transplanting 10(5) cells of bone marrow of C57BL mice to the lethally irradiated recipients (CBA X C57BL) F1 of different age (2 to 11 months). In the control experiments the bone marrow cells at the same dose were introduced to the lethally irradiated syngenic (C57BL) mice. The most pronounced inhibition of the parental stem cells proliferation was registered in 2 months old recipients F1 (4.7 times), it was somewhat weakened in 3 months old and animal in 4--11 months old recipients (1.1 to 1.8 times). The thymectomy of adult recipients F1 did not eliminate the expression of allogenic inhibition.
D000375:Aging; D000818:Animals; D016026:Bone Marrow Transplantation; D003114:Colony-Forming Units Assay; D005260:Female; D006084:Graft Rejection; D006824:Hybridization, Genetic; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011830:Radiation Effects; D013934:Thymectomy; D014184:Transplantation, Homologous
Vliianie vozrasta retsipientov na proiavlenie éffekta allogennoĭ ingibitsii.