[Kidney transplantation in children].
Ten years' experience of renal transplantation in 40 children (aged 5--18 years) is reviewed. Including 3 second transplantations 40 cadaver grafts and 3 living donor grafts were transplanted. Mean graft survival was found to be 19 months, the longest being 8 years. At the time of last examination 24 children were alive wtith a functioning graft (mean serum creatinine level 1.5 mg/dl). After graft failure 9 children were again on intermittent hemodialysis. 7 children had died mainly because of infections or cardiovascular complications. Cumulative survival rate of patients and cadaver grafts after 2 years was 84 and 53% respectively. Growth velocity was variable but improved in the majority of patients compared to the previous dialysis period. Full social rehabilitation could be achieved in every case. Main complications were acute rejections (irreversible in 7 of 67), chronic rejections (irreversible in 6 of 10), side effects of immunosuppressive drugs (infections; hematologic, metabolic, and bone disorders), hypertension (60%), recurrence of primary renal disease (in 5 of 9 patients with focal segmental glomerulosclerosis) and surgical complications (28%). Therapeutic guide-lines are given emphasizing the role of specialized children's centres and the cooperation between pediatric nephrologists, immunologists, urologists and psychologists including the time before, during and after transplantation.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003141:Communicable Diseases / Q000209:etiology; D006084:Graft Rejection; D006801:Humans; D007165:Immunosuppression Therapy / Q000592:standards; D007166:Immunosuppressive Agents / Q000009:adverse effects; D007674:Kidney Diseases / Q000151:congenital; D007676:Kidney Failure, Chronic / Q000628:therapy*; D016030:Kidney Transplantation; D011379:Prognosis; D006435:Renal Dialysis; D012741:Sexual Maturation; D014184:Transplantation, Homologous
D007166:Immunosuppressive Agents
Nierentransplantation im Kindesalter.