Active immunisation of mice against muscle damage mediated by Candida albicans.
The effect of active immunisation on muscle damage after systemic infection with Candida albicans was examined in a murine model. Mice were successfully immunised against acute muscle damage by vaccines of viable, nonviable, or disrupted C. albicans. In addition, markedly enhanced survival of immunised mice was demonstrated over a 4-week interval. There was protection against muscle damage in immunised mice without a reduction in the number of organisms present in cardiac tissue. The data indirectly implicate the role of humoral immunity in the protection afforded by immunisation.
D000818:Animals; D002176:Candida albicans / Q000276:immunology*; D002177:Candidiasis / Q000276:immunology* / Q000473:pathology; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D005657:Fungal Vaccines; D007114:Immunization; D051379:Mice; D009132:Muscles / Q000473:pathology; D014613:Vaccines, Attenuated
D005657:Fungal Vaccines; D014613:Vaccines, Attenuated; D003402:Creatine Kinase