Extrapituitary action of gonadotropin-releasing hormone: direct inhibition ovarian steroidogenesis.
Gonadotropin-releasing hormone (GnRH) and its agonistic analogs inhibited the follicle-stimulating hormone (FSH)-induced increase of estrogen and progesterone production in vitro by rat ovarian granulosa cells. Likewise, GnRH analogs inhibited FSH-induced changes in ovarian function in hypophysectomized rats in vivo. These results indicate that GnRH, in addition to its well-known gonadotropin-releasing action in the pituitary, exerts a direct inhibition of ovarian steroidogenesis.
D000818:Animals; D002478:Cells, Cultured; D004967:Estrogens / Q000096:biosynthesis*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000037:antagonists & inhibitors*; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology*; D006107:Granulosa Cells / Q000187:drug effects; D007016:Hypophysectomy; D010053:Ovary / Q000187:drug effects* / Q000378:metabolism; D011372:Progestins / Q000096:biosynthesis*; D051381:Rats
D004967:Estrogens; D011372:Progestins; D007987:Gonadotropin-Releasing Hormone; D005640:Follicle Stimulating Hormone