[Dependence of the viability and mutability of Escherichia coli K-12 cells on the balance of DNA and protein syntheses. II. The effect of disturbance in the balance of DNA and protein syntheses on the cellular mutability and viability of rec+ and rec- strains treated with nalidixic acid].
The changes in the survival and mutagenesis of rec+ and rec- Escherichia coli K-12 strains, treated with the selective inhibitor of DNA synthesis, nalidixic acid, are found to be due to the processes of the stabilization and repair of the metabolic gaps in DNA chains, which depend on the balance of DNA and protein synthesis. The various character is observed of the relation between the survival and the mutagenesis and the balance of DNA and protein syntheses in cells which are valuable (rec+) and defective (rec-) for the processes of DNA repair.
D001426:Bacterial Proteins / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D002701:Chloramphenicol / Q000494:pharmacology; D004260:DNA Repair / Q000187:drug effects; D004269:DNA, Bacterial / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D009154:Mutation; D009268:Nalidixic Acid / Q000494:pharmacology*
D001426:Bacterial Proteins; D004269:DNA, Bacterial; D009268:Nalidixic Acid; D002701:Chloramphenicol
Zavisimost' zhiznesposobnosti i mutabil'nosti kletok Escherichia coli K-12 ot balansa sintezov DNK i belka. Soobshchenie II. Vliianie narusheniia balansa sintezov DNK i belka na mutabil'nost' i zhiznesposobnost' kletok rec+ i rec- -shtammov, obrabotannykh nalidiksovoĭ kislotoĭ.