Evaluation of vaginal antifungal formulations in vivo.
Relatively simple and rapid procedures have been developed for evaluating the local efficacy of vaginal antifungal agents in vivo in a vaginal candidiasis model in ovariectomized rats. The results of this investigation indicate that the model and methods described are quite suitable for screening potential antifungal substances and for assessing the chemotherapeutic effectiveness of new antifungal agents and formulations before carrying out clinical studies.
D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D002176:Candida albicans / Q000302:isolation & purification; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy* / Q000382:microbiology; D003022:Clotrimazole / Q000627:therapeutic use; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005260:Female; D008825:Miconazole / Q000627:therapeutic use; D009761:Nystatin / Q000627:therapeutic use; D051381:Rats; D014621:Vagina / Q000382:microbiology
D000935:Antifungal Agents; D009761:Nystatin; D008825:Miconazole; D003022:Clotrimazole