[Ultrastructural and autoradiographic analysis of the cellular reactivity of the exo- and endocrine epithelium of the frog pancreas under the action of cobalt chloride].
The frog pancreatic epithelium was studied using morphometry, autoradiography and electron microscopy during the treatment with cobalt chloride (10 mg/100 g body wieght). In response to this treatment, generative changes in some exocrine cells were revealed. At the same time, those of cells, whose nuclei were in the state of DNA synthesis, increased in number. Cobalt chloride resulted in endocrine A-cells damage. A compensation of the broken endocrine A-cell function was maintained in a transformation of the exocrine epithelium into endocrine A-cells and in the appearance of intermediate acinar-islet cells, as well as in islet A-cell hyperplasia.
D000818:Animals; D001001:Anura; D001345:Autoradiography; D003035:Cobalt / Q000494:pharmacology*; D004848:Epithelium / Q000187:drug effects / Q000648:ultrastructure; D007515:Islets of Langerhans / Q000187:drug effects* / Q000648:ultrastructure; D008938:Mitosis / Q000187:drug effects; D010179:Pancreas / Q000187:drug effects* / Q000648:ultrastructure; D011896:Rana temporaria
D003035:Cobalt
Ul'trastrukturnyĭ i avtoradiograficheskiĭ analiz reaktivnosti kletok ékzo-i éndokrinnogo épiteliia podzheludochnoĭ zhelezy liagushki pri deĭstvii khloristogo kobal'ta.