title: [Evaluation of the inhibiting action of virazole on the reproduction of the vaccinia virus in tissue culture].
abstract: Experimental data of the evaluation of the antiviral activity of virazole in tissue culture using the fluorescent antibody technique are presented. Administration of virazole in the maintenance medium in a concentration range of 800--6.25 microgram/ml immediately after vaccinia virus adsorption exerts a marked inhibiting effect reducing virus reproduction by 3.1--1.6 1g, respectively. The chemotherapeutic index of the drug is 128. In a one-cycle experiment, virazole in the minimal effective concentration had the same inhibiting effect as metizason in the maximal tolerable concentration.
mesh_terms: D000818:Animals; D000998:Antiviral Agents; D004305:Dose-Response Relationship, Drug; D005455:Fluorescent Antibody Technique; D008720:Methisazone / Q000494:pharmacology; D012254:Ribavirin / Q000494:pharmacology*; D012263:Ribonucleosides / Q000494:pharmacology*; D014616:Vaccinia virus / Q000187:drug effects*; D014776:Virus Cultivation; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D012263:Ribonucleosides; D012254:Ribavirin; D008720:Methisazone
vernacular_title: Otsenka ingibiruiushchego deĭstviia virazola na reproduktsiiu virusa ospovaktsiny v kul'ture tkani.