[Cerebrospinal fluid pressure studies after the intravenous administration of the steroid narcotic, alphaxolone + alphadolone acetate (Althesin)].
The effect of alphaxalon + alphadolon-acetate on cerebrospinal fluid pressure (CSFP), mean arterial blood pressure (MPA), heart rate (BMP) and blood gases was investigated in 18 patients. Cerebral perfusion pressure (CPP) was calculated from the difference MAP minus CSFP. Alphaxalon + alphadolon-acetate lowered the normal CSFP and normalized ketamin induced increase of CSFP. Premedication with alphaxalon + alphadolon-acetate delayed the ketamin induced increase of CSFP, which returned to norm after a second dose of alphaxalon + alphadolon-acetate. This effect was seen despite elevation of pCO2 in all patients breathing spontaneously.
D000328:Adult; D000368:Aged; D000530:Alfaxalone Alfadolone Mixture / Q000008:administration & dosage*; D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D006801:Humans; D007275:Injections, Intravenous; D007427:Intracranial Pressure / Q000187:drug effects*; D007649:Ketamine; D008875:Middle Aged; D010313:Partial Pressure; D011674:Pulse / Q000187:drug effects
D007649:Ketamine; D000530:Alfaxalone Alfadolone Mixture
Liquordruckuntersuchungen nach intravenöser Gabe des Steroid-Narkotikums Alphaxalon + Alphadolon-Azetat (Althesin).