Is human arterial smooth muscle cell proliferation regulated by prostacyclin?
Activated smooth muscle cells exhibit a statistically significant (p less than 0.025) higher prostacyclin production than the contractiles. It is concluded, that the proliferation of the metabolically activated cells, which is an early event in atherogenesis, could be due to prostacyclin regulation.
D000328:Adult; D001161:Arteriosclerosis / Q000209:etiology; D002455:Cell Division; D003094:Collagen / Q000096:biosynthesis; D004549:Elastin / Q000096:biosynthesis; D011464:Epoprostenol / Q000096:biosynthesis / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009131:Muscle, Smooth, Vascular / Q000166:cytology* / Q000378:metabolism; D011453:Prostaglandins / Q000502:physiology*; D013157:Splenic Artery
D011453:Prostaglandins; D003094:Collagen; D004549:Elastin; D011464:Epoprostenol