New bioassay for screening immunotoxic agents.
A new bioassay for evaluation of compounds potentially toxic for the immune system is described. It is suitable for the measurement of enhancement of primary antibody response and of enhancement and inhibition of memory development in vivo. It utilizes immunoenzymatic techniques which can readily be automated and thus allow the screening of many compounds at relatively low cost. It can provide answers regarding the safety or danger of each compound tested within 30-45 days.
D000818:Animals; D000917:Antibody Formation; D004353:Drug Evaluation, Preclinical; D007109:Immunity; D007156:Immunologic Memory; D007158:Immunologic Techniques; D007165:Immunosuppression Therapy; D008198:Lymph Nodes / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL / Q000276:immunology; D013154:Spleen / Q000276:immunology; D014116:Toxicology