[Organ tolerance and incomplete bone marrow chimera in dogs].
Cyclophosphamide-induced chimeras develop organ tolerance as do radiation chimeras, as long as hemopoietic cells of donor origin are detectable, independent of the degree of chimerism (n = 7). 4 of 7 dogs with reversion of chimerism rejected their kidney grafts within 11 to 29 days. Three of them, however, retained their kidney grafts permanently indicating that a transient chimerism of a few months duration may be sufficient for induction of tolerance to marrow donor organs in Cy-chimeras. The results suggest that the reversion of chimerism in Cy-chimeras may be due to different mechanisms either immunological rejection or a non-immunological substitution of the grafted marrow by the host's own hemopoiesis.
D000818:Animals; D016026:Bone Marrow Transplantation; D002678:Chimera / Q000187:drug effects*; D003520:Cyclophosphamide / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D006084:Graft Rejection; D006410:Hematopoiesis; D007108:Immune Tolerance; D016030:Kidney Transplantation; D008213:Lymphocyte Activation; D008297:Male; D014181:Transplantation Immunology; D014184:Transplantation, Homologous
D003520:Cyclophosphamide
Organtoleranz und inkompletter Knochenmarkchimärismus beim Hund.