title: A comparison of immunologic profiles and their influence on bacteremia in surgical patients with a high risk of infection.
abstract: Prospective sequential studies of the antibacterial function of neutrophils, lymphocyte responsiveness, opsonic capacity of serum and serum levels of C3(B), properdin, factor B, IgG, and albumin were made in 32 patients with severe burn injury (greater than or equal to 45%), 21 patients with severe multisystem traumatic injury, 20 high-risk, infected patients, and 22 renal transplant patients. Fifty-five episodes of bacteremia occurred in 37 of the 95 patients. Abnormal neutrophil function was clearly associated as a predisposing factor to these episodes, whereas there was no association between bacteremia and low serum levels of C3, IgG, factor B, or properdin. C3, factor B, and IgG usually rose following bacteremia as acute phase proteins, but there was evidence of a consumptive opsoninopathy in 11% of episodes. Defective opsonization was associated with a high risk of bacteremia only when there was a coexisting abnormality of neutrophil function (88% of such patients became bacteremic). None of 27 nonburned patients tested with delayed hypersensitivity antigens responded normally, and there was regularly depression of lymphocyte responsiveness to phytohemagglutinin-A and concanavalin-A in a whole blood assay related to serum immunosuppressive factors, but poor responsiveness was not associated with bacteremia.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000276:immunology; D002056:Burns / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D003179:Complement C3b / Q000032:analysis; D011415:Complement Factor B / Q000032:analysis; D006801:Humans; D007158:Immunologic Techniques; D007165:Immunosuppression Therapy; D016030:Kidney Transplantation; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology; D009895:Opsonin Proteins / Q000276:immunology*; D011446:Prospective Studies; D012306:Risk; D018805:Sepsis / Q000276:immunology*; D014184:Transplantation, Homologous; D014947:Wounds and Injuries / Q000276:immunology*
chemical_list: D009895:Opsonin Proteins; D003179:Complement C3b; D011415:Complement Factor B