[The biochemical activity of the aflatoxins (author's transl)].
Results of experiments with the Salmonella typhimurium-liver microsome technique make it evident that the mutagenic and carcinogenic metabolite of aflatoxin B1 is aflatoxin B1-2,3-oxide. This compound forms adducts with guanine in DNA. There is a close relationship between the mutagenic activity and the hepatocarcinogenic property of the different aflatoxin derivatives.
D000348:Aflatoxins / Q000378:metabolism*; D002273:Carcinogens; D009153:Mutagens; D012486:Salmonella typhimurium / Q000378:metabolism
D000348:Aflatoxins; D002273:Carcinogens; D009153:Mutagens
Die biochemische Wirkungsweise der Aflatoxine.