Mediation by serotonin of gold thioglucose-induced necrosis of the ventromedial hypothalamus.
Agents that lower serotonin levels or inhibit serotonin action prevent GTG-indurea and that such damage leads to abnormally increased capillary permeability. Since the VMH is rich in serotonin and since serotonin is a potent oedema-producing agent mice, these findings indicate that the production of necrosis by GTG is mediated by release of serotonin from the damaged pericapillary processes.
D000818:Animals; D006051:Aurothioglucose / Q000494:pharmacology*; D001812:Blood-Brain Barrier / Q000187:drug effects; D001929:Brain Edema / Q000139:chemically induced / Q000517:prevention & control; D005260:Female; D006046:Gold / Q000494:pharmacology*; D007031:Hypothalamus / Q000187:drug effects*; D007033:Hypothalamus, Middle / Q000187:drug effects*; D007490:Iproniazid / Q000494:pharmacology; D051379:Mice; D009336:Necrosis; D011985:Receptors, Serotonin / Q000187:drug effects; D012701:Serotonin / Q000502:physiology*; D012702:Serotonin Antagonists / Q000494:pharmacology
D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D006051:Aurothioglucose; D012701:Serotonin; D006046:Gold; D007490:Iproniazid