[Role of possible endotoxin contaminants present in some preparations of biological products and injectable drugs].
On the basis of personal contributions and of most recent data, the A. reports some observations and comments regarding the role of possible contaminating endotoxins demonstrated in some biological products and parenteral solutions used in clinical and experimental studies. Since endotoxins even in minute amounts have a variety of biological effects, the use of such contaminated preparations can lead to spurious results and erroneous conclusions. The Limulus assay appears to be a rapid, specific and sensitive method for detection and quantitation of endotoxin in various biological and pharmaceuticals products before they are used in clinical and experimental investigations.
D001688:Biological Products / Q000592:standards*; D004340:Drug Contamination; D004731:Endotoxins
D001688:Biological Products; D004731:Endotoxins
Osservazioni e commenti sul ruolo di possibili contaminanti endotossinici presenti in alcune preparazioni di prodotti biologici e di farmaci iniettabili.