[Ultrastructural study of rat liver after administration of an aminated steroid (author's transl)].
The administration of amino-3 beta hydroxy-20 beta pregnene-5, to the male Wistar rat, per os, at doses of 100 and 200 mg/kg/24 h, induce the development of a chronic active hepatitis. The ultrastructural observation shows slight changes only in perilobular hepatocytes at the beginning of treatment; then hepatocellular alterations progressively increase and may be observed in the whole lobule after 40 and 80 days of treatment; the progression of hepatocellular damage is associated with collagen increase and bile duct proliferation. The interest of this experimental hepatitis, as a model analogous to human chronic active hepatitis, is discussed.
D000818:Animals; D001652:Bile Ducts / Q000473:pathology; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology; D004195:Disease Models, Animal; D006520:Hepatitis, Animal / Q000139:chemically induced* / Q000473:pathology; D008099:Liver / Q000473:pathology / Q000648:ultrastructure*; D008297:Male; D011283:Pregnenes / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats
D011283:Pregnenes
Etude ultrastructurale du tissu hépatique chez le rat, après administration d'un stéroïde aminé.