[The molecular biology of aging -- 15: Structure and function of the genetic apparatus in aging. II. Synthesis and metabolism of RNA].
With aging in different organs there are similar or tissue specific changes of the ribonucleic acids in respect of the quantity, the spectrum of different RNA species and the metabolism of RNA. Among these processes the template function of the chromatin and the behaviour of the RNA polymerases are important influencing factors. In aging the sensitivity of the RNA synthesis against hormonal stimulation is decreased in the most cases. A survey about the results of many in vivo and in vitro experiments of the literature is given. The opinion is advocated that the problems of the gene regulation and gene expression are a important field of work in the experimental gerontology.
D000305:Adrenal Cortex Hormones / Q000502:physiology; D000375:Aging; D000818:Animals; D002843:Chromatin / Q000378:metabolism; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology; D066298:In Vitro Techniques; D051379:Mice; D012313:RNA / Q000096:biosynthesis / Q000378:metabolism*; D051381:Rats
D000305:Adrenal Cortex Hormones; D002843:Chromatin; D012313:RNA; D006854:Hydrocortisone
Zur Molekularbiologie des Alterns -- 15. Mitteilung: Struktur und Funktion des genetischen Apparates im Alternsgang. II. Synthese und Stoffwechsel der RNS.