In situ formation of antigen-antibody complexes in the mouse glomerulus.
Intravenous administration of heat-aggregated bovine serum albumin (BSA) to mice resulted in localization of micro-particulate BSA in the mesangial region of the glomerulus. Subsequent intravenous administration of rabbit anti-BSA antibody at a time when no free antigen remained in the circulation produced localization of antibody and fixation of mouse complement within the glomerulus in a pattern corresponding to that of the heat-aggregated BSA. This apparent in situ formation of immune complexes in the glomerulus is similar to that of the classical Arthus phenomenon in the skin.
D000818:Animals; D000906:Antibodies / Q000276:immunology; D000936:Antigen-Antibody Complex; D000941:Antigens / Q000276:immunology; D003176:Complement C3 / Q000276:immunology; D004195:Disease Models, Animal; D005455:Fluorescent Antibody Technique; D005921:Glomerulonephritis / Q000276:immunology; D007678:Kidney Glomerulus / Q000276:immunology*; D051379:Mice; D008808:Mice, Inbred CBA; D012710:Serum Albumin, Bovine / Q000276:immunology
D000906:Antibodies; D000936:Antigen-Antibody Complex; D000941:Antigens; D003176:Complement C3; D012710:Serum Albumin, Bovine