Detection of circulating immune complexes in alcoholic liver disease.
Sera of twenty-five patients with alcoholic liver disease and forty normal control sera were screened for circulating immune complexes by means of the anti-antibody neutralization test and by Raji-cell membrane immunofluorescence assay. IgG-containing immune complexes were detected in thirteen out of twenty-five patients with alcoholic liver diseases and in one out of forty normal individuals; in addition, IgA-containing complexes were demonstrated in seven out of thirteen sera positive for IgG complexes. The presence of immune complexes was restricted to alcoholic hepatitis and active cirrhosis, thus indicating a relationship with disease severity.
D000936:Antigen-Antibody Complex; D005455:Fluorescent Antibody Technique; D006519:Hepatitis, Alcoholic / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D008104:Liver Cirrhosis, Alcoholic / Q000276:immunology; D008108:Liver Diseases, Alcoholic / Q000276:immunology*; D009500:Neutralization Tests
D000936:Antigen-Antibody Complex; D007070:Immunoglobulin A; D007074:Immunoglobulin G