Platinum(II) complexes generate frame-shift mutations in test strains of Salmonella typhimurium.
cis-Diamminodichloroplatinum(II) (cis-PDD) and diaquoethylenediamineplatinum(II) induce histidine revertants in Salmonella typhimurium strains TA98 (frame-shift mutation) and TA100 (base-pair substitution mutation). A linear dose--response relationship is found with cis-PDD acting on TA98 and TA100. Salmonella typhimurium strains TA1535, TA1537 and TA1538 are not sensitive to the mutagenic action of cis-PDD. All 5 strains are sensitive to the toxic effect of cis-PDD. Platinum(II) complexes induce mutations (frame-shift or base-pair substitution) only in strains carrying the R-factor plasmid.
D002945:Cisplatin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005029:Ethylenediamines / Q000494:pharmacology; D009153:Mutagens; D009944:Organoplatinum Compounds; D010984:Platinum / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000254:growth & development; D013045:Species Specificity
D005029:Ethylenediamines; D009153:Mutagens; D009944:Organoplatinum Compounds; D010984:Platinum; C020886:diaquoethylenediamineplatinum(II); D002945:Cisplatin