Lymphoid cells in endotoxin-induced production of the amyloid-related serum amyloid A protein.
Endotoxin-treated mice exhibit a rapid rise in the level of the serum amyloid A (SAA) protein, but this effect is not observed in endotoxin-resistant C3H/HeJ mice. To evaluate the role of lymphoid cells in the production of SAA protein, C3H/HeJ mice were adoptively transfused with endotoxin-sensitive (C3H/HeN) bone marrow cells. After such adoptive transfer, endotoxin treatment of C3H/HeJ mice resulted in high serum levels of SAA protein. The ability of chimeric mice to make SAA protein correlated with the presence of endotoxin-sensitive B lymphocytes and macrophages. These findings suggest that lymphocytes and/or macrophages play an important role in initiating SAA protein synthesis after endotoxin treatment and suggest a possible mechanism by which chronic infection or inflammation leads to amyloidosis.
D000682:Amyloid / Q000096:biosynthesis*; D000818:Animals; D001402:B-Lymphocytes / Q000502:physiology*; D016026:Bone Marrow Transplantation; D004731:Endotoxins / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008264:Macrophages / Q000502:physiology*; D051379:Mice; D008809:Mice, Inbred C3H; D000685:Serum Amyloid A Protein / Q000096:biosynthesis*; D014184:Transplantation, Homologous
D000682:Amyloid; D004731:Endotoxins; D008070:Lipopolysaccharides; D000685:Serum Amyloid A Protein