Rate of disappearance in plasma of synthetic LH-RH intravenously injected in man.
The rate of disappearance of intravenously injected LH-RH was studied in 6 human volunteers. The blood samples were taken every 20 sec from the time of injection to time +5 min and every 30 sec from time +5 min to time +10 min. The half-life of LH-RH was calculated in the interval of 3-10 min, and was found to be 2.4 +/- 0.4 min. The amounts of LH-RH estimated in the vascular compartment were relatively low when compared to the total amount of injected LH-RH. This observation suggests a rapid and important passage towards the extravascular compartment.
D000328:Adult; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000097:blood*; D006207:Half-Life; D006728:Hormones / Q000097:blood; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D011863:Radioimmunoassay
D006728:Hormones; D007987:Gonadotropin-Releasing Hormone