Use and abuse of systemic corticosteroid therapy.
Steroid-responsive acute dermatoses should be treated with a single morning dose of prednisone for approximately 2 weeks. It is necessary to "taper" a short course of oral prednisone given by this method. Chronic dermatoses should be treated whenever possible with prednisone used in the morning and on alternate days. This method is effective, is free of most side effects, and suppresses the HPA axis minimally. There are few real advantages in using intramuscular corticosteroids. TAC is an unusually strong suppressor of the HPA axis. For chronic dermatoses, a less suppressive preparation might best be chosen if the physician feels that the intramuscular route is the most reasonable one. In any event TAC should never be used more often than every two months. Finally, the time-course of HPA recovery following short courses of steroids is presently unknown. Nonetheless, some astute critics of steroid metabolism have felt obliged to advise us that individuals who have received from 1 to 4 weeks of suppressive steroid treatment should be suspect as to the integrity of their HPA axis in stressful situations for up to one year. The withdrawal from, as well as the use of, systemic corticosteroids requires a creative and critical physician.
D000305:Adrenal Cortex Hormones / Q000494:pharmacology / Q000627:therapeutic use*; D003872:Dermatitis / Q000188:drug therapy*; D004334:Drug Administration Schedule; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000503:physiopathology; D010913:Pituitary-Adrenal System / Q000187:drug effects / Q000503:physiopathology; D011241:Prednisone / Q000494:pharmacology; D013375:Substance Withdrawal Syndrome; D014222:Triamcinolone Acetonide / Q000494:pharmacology
D000305:Adrenal Cortex Hormones; D014222:Triamcinolone Acetonide; D011241:Prednisone