[The influence of dopamine of kidney function during continuous positive-pressure ventilation (PEEP) (author's transl)].
In a group of 20 patients the influence of continuous positive-pressure Ventilation (PEEP) on cardiac output, kidney function and renal and intrarenal hemodynamics was investigated. During ventilation with PEEP 10 ccm H2O a reduction of cardiac output, glomerular filtrationrate, sodium excretion and urinary output was observed. Renal blood flow, especially the cortical fraction, also decreased. Dopamine infusion, in a dose of 4 ng.kg-1.min-1, during continuous PEEP-ventilation, induced an increase of cardiac output, glomerular filtrationrate, renal sodium excretion and diuresis. The decreased renal cortical perfusion particularly was improved by Dopamine application.
D000368:Aged; D002302:Cardiac Output / Q000187:drug effects; D004231:Diuresis / Q000187:drug effects; D004298:Dopamine / Q000627:therapeutic use*; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D007385:Intermittent Positive-Pressure Ventilation; D007668:Kidney / Q000098:blood supply / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D012131:Respiratory Insufficiency / Q000188:drug therapy*; D012964:Sodium / Q000652:urine
D012964:Sodium; D004298:Dopamine
Der Einfluss von Dopamin auf die Nierenfunktion während kontinuierlicher Uberdruckbeatmung (PEEP).