Antioxidants reduce the mutagenic effect of malonaldehyde and beta-propiolactone. Part IX. Antioxidants and cancer.
Increasing concentrations of malonaldehyde and beta-propiolactone were increasingly mutagenic with 7 mutants of Salmonella typhimurium, 5 of which mutated bya frameshift mechanism and 2 of which mutated through base-pair substitution. The antioxidants vitamin C, vitamin E, selenium and butylated hydroxytoluene (BHT) at 3 logarithmic concentrations markedly reduced mutagenesis in those strains which mutated by frameshift mechanism.
D001205:Ascorbic Acid / Q000494:pharmacology; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005821:Genetic Techniques; D007783:Lactones / Q000494:pharmacology*; D008314:Malonates / Q000494:pharmacology*; D008315:Malondialdehyde / Q000494:pharmacology*; D009153:Mutagens / Q000037:antagonists & inhibitors; D011420:Propiolactone / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000235:genetics; D012643:Selenium / Q000494:pharmacology; D014810:Vitamin E / Q000494:pharmacology
D007783:Lactones; D008314:Malonates; D009153:Mutagens; D014810:Vitamin E; D002084:Butylated Hydroxytoluene; D008315:Malondialdehyde; D011420:Propiolactone; D012643:Selenium; D001205:Ascorbic Acid