[Metabolism of proliferating and resting cells].
This review concerns the modern trends and experimental approaches to the study of cell cycle (cell population kinetics, cell structure and functions at various steps of the cycle,, etc.) and their input into the current views of cell proliferation controls. The resting state of the cell is considered and metabolic features of proliferating and resting cells are compared. Evidence is presented that resting cells are metabolically active and less resistant to the damaging factors that it has been previously supposed. The importance of this finding for biology and medicine, especially for cancer chemotherapy, is discussed.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D001692:Biological Transport; D002453:Cell Cycle / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002471:Cell Transformation, Neoplastic / Q000187:drug effects / Q000378:metabolism; D002477:Cells / Q000187:drug effects / Q000378:metabolism*; D002843:Chromatin / Q000378:metabolism; D004789:Enzyme Activation; D046911:Macromolecular Substances; D009369:Neoplasms / Q000378:metabolism; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D002843:Chromatin; D046911:Macromolecular Substances
Metabolizm proliferiruiushchikh i pokoiashchikhsia kletok.