[Problems in clinical testing of a psychotropic substance examplified by L-5-HTP-ester (author's transl)].
An i.v. injectable form of the serotonin-precursor L-5-hydroxytyptophan (Ro 3-5940) was investigated for its acute psychotropic effect. The difficulties are presented which had to be overcome as it was not known which effects could be expected. It was shown that for the intensive psychotropic effect found, it was not possible to use a long and detailed self-rating scale. The problem of informed consent is discussed.
D006916:5-Hydroxytryptophan / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D000928:Antidepressive Agents; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D006801:Humans; D011619:Psychotropic Drugs; D012107:Research Design
D000928:Antidepressive Agents; D011619:Psychotropic Drugs; D006916:5-Hydroxytryptophan
Probleme bei der klinischen Prüfung einer psychotropen Substanz am Beispiel eines L-5-HTP-esters