Antimitogenic activity of homogenates and culture filtrates of actinomycetes.
Filtrates of cells homogenates and culture supernatants of some strains of Nocardia inhibited phytohemagglutinin-induced transformation of horse blood lymphocytes. The most active preparation that inhibited transformation by over 90% were obtained from strains of Nocardia asteroides N 668, N. asteroides N 1, N. amarae Se 6, N. amarae Se 97, and N. erythropolis N 11. Concentrations of the active factor were probably low since antimitogenic activity disappeared after 10-fold dilution of the preparations.
D003470:Culture Media; D008213:Lymphocyte Activation; D008938:Mitosis; D009616:Nocardia asteroides / Q000276:immunology*; D010835:Phytohemagglutinins
D003470:Culture Media; D010835:Phytohemagglutinins