Evaluation of the efficacy and safety of guanabenz versus clonidine.
The antihypertensive efficacy and safety of guanabenz were evaluated against clonidine in two groups of 18 patients with uncomplicated essential hypertension. Both compounds reduced systolic and diastolic blood pressure at the doses used, whether pressures were measured in the supine or standing positions. Side-effects, such as dry mouth and drowsiness, were similar in both groups of patients. No postural hypotension occurred.
D000328:Adult; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D003000:Clonidine / Q000008:administration & dosage* / Q000009:adverse effects; D004341:Drug Evaluation; D006143:Guanabenz / Q000008:administration & dosage* / Q000009:adverse effects; D006146:Guanidines / Q000008:administration & dosage*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008875:Middle Aged; D011674:Pulse / Q000187:drug effects
D000959:Antihypertensive Agents; D006146:Guanidines; D006143:Guanabenz; D003000:Clonidine