Reduction of postoperative infection in elective colon surgery with preoperative administration of kanamycin and erythromycin.
The results of a randomized prospective preoperative antibiotic study in colon surgery is presented. Antibiotics were given by mouth for 2 days prior to operation: kanamycin (1 gm four times a day) and erythromycin (750 mg three times a day). Kanamycin combined with erythromycin significantly reduced wound infection as compared to kanamycin with a placebo (three of 38 vs. 16 of 39, P less than 0.001). Thus oral aminoglycoside given alone appears to be inadequate to offer protection against postoperative infection in elective colon surgery.
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D003082:Colectomy; D003125:Colostomy; D004311:Double-Blind Method; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D004917:Erythromycin / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007612:Kanamycin / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D010919:Placebos; D011300:Preoperative Care; D013530:Surgical Wound Infection / Q000517:prevention & control*
D010919:Placebos; D007612:Kanamycin; D004917:Erythromycin