Extracorporeal perfusion without anticoagulation and the response to endotoxin.
The results of this study show that an extracorporeal perfusion system without anticoagulation can be established in the dog under certain conditions. The exact mechanisms merit further investigation. It also points to a model to study the effects of endotoxin without heparin interference and as another model for studying the canine blood coagulation system.
D000818:Animals; D000925:Anticoagulants / Q000008:administration & dosage*; D001776:Blood Circulation Time; D001777:Blood Coagulation / Q000187:drug effects; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D004285:Dogs; D004731:Endotoxins / Q000494:pharmacology*; D004926:Escherichia coli; D005112:Extracorporeal Circulation / Q000379:methods*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006400:Hematocrit; D006614:Hindlimb / Q000098:blood supply; D008297:Male
D000925:Anticoagulants; D001786:Blood Glucose; D004731:Endotoxins