Effect of acetylsalicylate on surgical bleeding, postoperative mortality and allograft survival in rats undergoing heart transplantation.
18 rats were treated with L-ASA before heart transplantation and daily thereafter until death or rejection. 22 animals acted as controls. A significantly higher post-operative mortality rate, without any significant modification of the transplant survival time, was found in L-ASA-treated group.
D000818:Animals; D001241:Aspirin / Q000494:pharmacology* / Q000627:therapeutic use; D001777:Blood Coagulation / Q000187:drug effects; D005260:Female; D006084:Graft Rejection / Q000187:drug effects*; D016027:Heart Transplantation; D006470:Hemorrhage / Q000139:chemically induced*; D009206:Myocardium / Q000276:immunology; D011183:Postoperative Complications / Q000139:chemically induced* / Q000517:prevention & control; D051381:Rats; D014184:Transplantation, Homologous
D001241:Aspirin