Lymphokine activity in the aqueous humour and in the subretinal fluid in various ophthalmic diseases.
The aqueous humour and the subretinal fluid were studied for migration-inhibition factor (MIF) activity by the capillary migration technique. The retrospective conclusions are based on the results obtained with 15-fold dilutions of aqueous humour and subretinal fluid of 12 patients. Under the conditions of the experiment a MIF activity over 30% was regarded as indicative of an active cell-mediated immune reaction. In case of a lower activity, the process was in general amenable to local treatment. In the light of further clinical observations, study of MIF activity is likely to prove a useful indicator of the local immune status and to provide therapeutic guidelines in various syndromes. In retinal detachment due to inflammatory uveitis it may furnish clues to the optimum time for surgery.
D000328:Adult; D001082:Aqueous Humor / Q000276:immunology*; D001834:Body Water / Q000276:immunology; D005128:Eye Diseases / Q000276:immunology*; D005129:Eye Foreign Bodies / Q000276:immunology; D005260:Female; D006801:Humans; D007961:Leukocyte Migration-Inhibitory Factors / Q000032:analysis*; D008222:Lymphokines / Q000032:analysis*; D008297:Male; D014605:Uveitis / Q000276:immunology
D007961:Leukocyte Migration-Inhibitory Factors; D008222:Lymphokines