Suppressed development of experimental glomerulonephritis in lactating rats.
Five of six lactating rats did not develop proteinuria after an injection of nephrotoxic serum, whereas four out of five non-lactating, non-pregnant rats showed the usual proteinuric response (P = 0.06). The amount of heterologous IgG deposits was similar in both groups, but the lactating rats had significantly less autologous IgG (P = 0.004) in the glomerular basal membrane. It is suggested that hormonal factors influence the development of experimental glomerulonephritis in lactating rats.
D000818:Animals; D001485:Basement Membrane / Q000276:immunology; D005260:Female; D005455:Fluorescent Antibody Technique; D005921:Glomerulonephritis / Q000209:etiology* / Q000276:immunology; D007106:Immune Sera; D007074:Immunoglobulin G / Q000032:analysis; D007678:Kidney Glomerulus / Q000276:immunology; D007684:Kidney Tubules / Q000276:immunology; D007774:Lactation; D011247:Pregnancy; D011507:Proteinuria / Q000209:etiology; D011817:Rabbits; D051381:Rats
D007106:Immune Sera; D007074:Immunoglobulin G