title: Juvenile dermatitis herpetiformis: an immunoelectron microscopic study.
abstract: Three children with persistent maculopapular and urticarial lesions and vesicles at the predilection sites of dermatitis herpetiformis (DH) were shown to exhibit typical granular, papillary IgA and C3 deposits in the tips of the dermal papillae, as demonstrated by direct immunofluorescence. By immunoelectron microscopy, the IgA deposits were associated with the microfibrils of the elastic fibres as has been described in DH of the adult. C3 deposits were scattered throughout the papillary dermis. Despite the similarity of the clinical appearance, history with regard to gluten sensitive enteropathy (GSE) varied in these three cases. In one child, the skin lesions appeared following faults in the gluten free diet on which he was kept for coeliac disease. Another child developed the skin lesions during a gluten free diet which was not strictly followed; no recurrences of gastrointestinal symptoms accompanied the eruption of DH. In the third case, no evidence for GSE in patient's history or in jejunal biopsies was present at the time of onset of DH.
mesh_terms: D002446:Celiac Disease / Q000150:complications; D002648:Child; D002675:Child, Preschool; D003176:Complement C3 / Q000032:analysis; D003874:Dermatitis Herpetiformis / Q000150:complications / Q000276:immunology* / Q000473:pathology; D005260:Female; D005455:Fluorescent Antibody Technique; D005983:Glutens; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D008297:Male; D008854:Microscopy, Electron; D012867:Skin / Q000276:immunology / Q000648:ultrastructure
chemical_list: D003176:Complement C3; D007070:Immunoglobulin A; D005983:Glutens