[Study of muscle hemodynamics during exercise: Physiological and pathological variations in Xe 133 elimination: A new method of interpretation (author's transl)].
Muscle blood flow measurements are of physiological (and pathological) significance only during effort. For this reason, the authors used Xe 133, which has been known since 1964, to measure regional muscle blood flow after its injection into the muscle, to quantify results during effort (pedalling). Effort is controlled by two measurable parameters: the weight lifted by the pedal and the frequency of movements. Curves showing the reduction in intramuscular Xe 133 levels cannot be mathematically formulated. It is easy, however, to measure their areas and thus define a mean elimination time (Tm) between times T1 and T2, beginning and end of effort, corresponding to activities A1 and A2 such that: formula: (see text). Normal Tm value, measured in 58 normal subjects with variable frequencies and weights lifted is: Tm = 1.70 +/- 0.38 min. The values in 70 patients with arteritis were significantly longer and can be greater than 3.5 min. This objective test could be of value in quintifying the effects of so-called vasodilators, both in patients with arteritis and venous insufficiency.
D006801:Humans; D008433:Mathematics; D008954:Models, Biological; D009132:Muscles / Q000098:blood supply*; D005082:Physical Exertion; D011865:Radioisotope Dilution Technique; D012039:Regional Blood Flow; D014980:Xenon Radioisotopes
D014980:Xenon Radioisotopes
Etude de l'hémodynamique musculaire au cours de l'exercice. Variations physiologiques et pathologiques de l'élimination du 133 Xe. Nouveau modèle d'interprétation.