Recurrence of dense deposits in transplanted kidneys: I. Sequential survey of the lesions.
Serial specimens from transplanted kidneys were obtained in 11 patients with dense deposit disease (DDD). The recurrence of DDD was obvious in 9 patients and appeared very early after grafting. Three different types of evolution of the lesions were observed. In 4 patients no modification of the lesions occurred with time, and in 2 of them the dense alteration alone persisted without any other glomerular changes. In 3 patients a progression of the lesions was observed, whereas a regression occurred in 1 other patient. From these observations the following sequence of the morphologic changes can be proposed: the dense alteration appears first and constitutes the specific marker of that disease; the C3 deposition in the kidney occurs later following the appearance of the dense lesion.
D001485:Basement Membrane / Q000473:pathology / Q000648:ultrastructure; D001706:Biopsy; D003176:Complement C3 / Q000276:immunology; D005455:Fluorescent Antibody Technique; D006651:Histocytochemistry; D006801:Humans; D007668:Kidney / Q000473:pathology / Q000648:ultrastructure; D007674:Kidney Diseases / Q000473:pathology / Q000601:surgery*; D007678:Kidney Glomerulus / Q000276:immunology / Q000473:pathology / Q000648:ultrastructure; D016030:Kidney Transplantation; D008854:Microscopy, Electron; D012008:Recurrence; D013997:Time Factors; D014184:Transplantation, Homologous
D003176:Complement C3