Systemic response to mydriatic eyedrops in neonates: mydriatics in neonates.
During routine dilation of 48 newborns, systemic responses and pupil dilation were monitored. Both 10 percent aqueous and viscous phenylephrine caused blanching around the eyes and produced considerable rise in blood pressure. Dilatation average 4.7 mm. In a double blind study, a 2.5 percent solution caused no skin blanching and no change in pressure or heart rate. Average dilation was 4.5 mm. No blood pressure changes were observed with either one percent cyclopentolate or one percent tropicamide. Average dilatations were 5.0 mm and 5.3 mm respectively. The above agents, used individually for a total dosage of three drops in each eye did not provide adequate dilation for a thorough funduscopic examination. Our protocol at United Hospitals Medical Center is a safe combination of drugs and provides excellent dilatation averaging greater th an 7 mm. No skin blanching or change in heart rate was observed.
D001724:Birth Weight; D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D003519:Cyclopentolate / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005865:Gestational Age; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007231:Infant, Newborn; D009184:Mydriatics / Q000494:pharmacology*; D010656:Phenylephrine / Q000494:pharmacology; D011680:Pupil / Q000187:drug effects*; D012867:Skin / Q000098:blood supply / Q000187:drug effects; D014331:Tropicamide / Q000494:pharmacology
D009184:Mydriatics; D010656:Phenylephrine; D003519:Cyclopentolate; D014331:Tropicamide