title: The effect of zinc tape upon wound healing. A biochemical, histochemical and histological study in rats.
abstract: The healing of excisional wounds in rats, which were treated with zinc tape, gauze sponge or porcine skin, was studied. Wound closure was completed earlier in zinc-tape-treated wounds than in wounds treated with a gauze sponge or porcine skin. Wound contraction was more pronounced in gauze- and porcine skin-treated wounds than in zinc-tape-treated wounds. More foreign body giant cells were seen 14 days after operation in gauze-treated contra zinc tape-treated wounds, whereas hydroxyproline concentration was higher in tape-treated wounds. Histochemically the acid phosphatase activity was pronounced in macrophages, foreign body giant cells and fibroblasts. The alkaline phosphatase activity was pronounced in granulocytes and fibroblasts. Quantitatively a reduction in alkaline phosphatase activity was seen in gauze-treated wounds from 7 to 14 days. A decrease was seen in albumin concentration in gauze- as well as zinc-tape-treated animals which was most pronounced after 7 days in the gauze-treated animals.
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism; D000287:Administration, Topical; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D002921:Cicatrix / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D006651:Histocytochemistry; D006909:Hydroxyproline / Q000378:metabolism; D008297:Male; D051381:Rats; D012709:Serum Albumin / Q000032:analysis; D012867:Skin / Q000473:pathology; D016038:Skin Transplantation; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects*; D015032:Zinc / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D012709:Serum Albumin; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D015032:Zinc; D006909:Hydroxyproline