[Role of epithelial basement membrane of the small intestine in providing immunologic homeostasis].
A morphometric method was used experimentally to prove the immune barrier function of the epithelial basal membrane of the small intestine mucous membrane. The epithelial basal membrane located on the border of the epithelium and connective tissue provides biochemical and immunological protection of the layer proper against penetrotion into it of antigens from the epithelium, being a barrier of immunological homeostasis. The damage of the epithelial membrane is accompanied by coming of the intestinal lumen antigens into the layer proper causing there a disturbance of immunological homeostasis. In response to this lymphoid cells migrate from the stroma to the epithelium towards the antigens, and lymphocytic reaction in the layer proper increases.
D000818:Animals; D001427:Bacterial Toxins / Q000276:immunology; D001485:Basement Membrane / Q000276:immunology* / Q000473:pathology; D004848:Epithelium / Q000276:immunology / Q000473:pathology; D006706:Homeostasis; D007082:Ileum / Q000276:immunology* / Q000473:pathology; D011817:Rabbits; D012482:Salmonella paratyphi A / Q000276:immunology; D012485:Salmonella typhi / Q000276:immunology; D012764:Shigella sonnei / Q000276:immunology
D001427:Bacterial Toxins
Rol' epitelial'noĭ bazal'noĭ membrany tonkoĭ kishki v obespechenii immunologicheskogo gomeostaza.