Comparison of human and bovine protoporphyria.
Protoporphyria (PP) is an inherited disorder of porphyrin metabolism in man in which there is excessive accumulation and excretion of protoporphyrin. Recently, a similar disorder has been described in cattle. In this report, the clinical, biochemical, and genetic features of bovine and human PP are compared. Human and bovine PP are characterized by photosensitivity and elevation of erythrocyte and fecal protoporphyrin levels. In both disorders, a deficiency of heme synthase activity is present in all tissues which have been examined. The diseases differ clinically in that hepatobiliary disease has been found thus far only in human PP. They also have different inheritance patterns. Human PP is an autosomal dominant disease, while initial studies strongly suggest that there is an autosomal recessive pattern of inheritance in bovine PP.
D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000201:enzymology / Q000235:genetics*; D003580:Cytochromes / Q000235:genetics; D004195:Disease Models, Animal; D006418:Heme / Q000235:genetics; D006420:Hemeproteins / Q000235:genetics; D006455:Hemoglobins, Abnormal / Q000235:genetics; D006801:Humans; D008107:Liver Diseases / Q000378:metabolism; D011164:Porphyrias / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D011166:Porphyrins / Q000235:genetics; D011524:Protoporphyrins / Q000378:metabolism
D003580:Cytochromes; D006420:Hemeproteins; D006455:Hemoglobins, Abnormal; D011166:Porphyrins; D011524:Protoporphyrins; D006418:Heme