Biological activity of metal complexes. I. Interaction of pt(II), pd(II) and rh(I) complexes with E. coli strains and with mice LS fibroblasts in vitro.
The effects of a number of Pt(II, Pd(II) and Rh(I) complexes against cultures of Escherichia coli (strains B, H10178, uvra-, recA-) and cultures of mice LS Fibroblasts were tested. Most of the compounds showed higher cytotoxic activity than the cis-Pt(NH3)2Cl2, the compound at present on clinical trial as antittumour drug. A new model of active compound is proposed.
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003603:Cytotoxins; D004926:Escherichia coli / Q000187:drug effects*; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D009942:Organometallic Compounds / Q000494:pharmacology*; D009944:Organoplatinum Compounds / Q000494:pharmacology*; D010165:Palladium / Q000494:pharmacology*; D012238:Rhodium / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D003603:Cytotoxins; D009942:Organometallic Compounds; D009944:Organoplatinum Compounds; D010165:Palladium; D012238:Rhodium