Allogeneic transplantation in low-grade malignant bone tumours. A new operative technique to avoid amputation.
A massive allografting of deep-frozen cadaver bone or hemi-joint was performed in 11 patients with tumours which were diagnosed as aggressive, low-grade malignancies. One patient died from a pre-existing hepatic insufficiency. The other 10 patients have been followed up from 1 to 8 years. These patients received two bone grafts and eight hemi-joint grafts around the knee joint. The operative procedure consisted of fixation of the graft by stable osteosynthesis, surrounding the graft-host junction with an autogeneic iliac chips cuff and, in cases of hemi-joint grafts, reconstruction of the ligaments. X-ray, scintigraphy and biopsy were used to judge the incorporation of the graft. The patients had to be prepared to face a considerable morbidity with long non-weight-bearing periods and possibly further operations. A full restitution of function was achieved in the bone graft cases. The patients with hemi-joint grafts were also able to retain their limb with a good or satisfactory function. No metastases or recurrences were experienced. The allograft procedure appears to be useful for younger adults, whose long life expectancy makes this operation justifiable, although the fate of cartilage still is unpredictable.
D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000601:surgery*; D016025:Bone Transplantation; D002356:Cartilage / Q000637:transplantation; D002804:Chondroblastoma / Q000601:surgery*; D005260:Female; D005354:Fibrosarcoma / Q000601:surgery*; D005500:Follow-Up Studies; D005870:Giant Cell Tumors / Q000601:surgery*; D006801:Humans; D008297:Male; D012516:Osteosarcoma / Q000601:surgery*; D011183:Postoperative Complications; D014184:Transplantation, Homologous