Anti-i cold agglutinins in choriocarcinomatosis: trophoblastic i antigen.
The fetal antigen i has been demonstrated by indirect immunofluorescence on cord erythrocytes and placental trophoblast. A patient with disseminated choriocarcinoma developed high-tire anti-i cold agglutinins, and minor elevation of anti-i titres was seen in four out of six further patients with treated choriocarcinoma. In normal pregnant women, 6% showed similar increases in anti-i titres.
D000328:Adult; D000373:Agglutinins / Q000032:analysis*; D001323:Autoantibodies / Q000032:analysis*; D001789:Blood Group Antigens; D002822:Choriocarcinoma / Q000097:blood / Q000276:immunology*; D003080:Cold Temperature; D005260:Female; D005312:Fetal Blood / Q000276:immunology; D005455:Fluorescent Antibody Technique; D006801:Humans; D007048:I Blood-Group System; D011247:Pregnancy; D014327:Trophoblasts / Q000276:immunology; D014594:Uterine Neoplasms / Q000097:blood / Q000276:immunology*
D000373:Agglutinins; D001323:Autoantibodies; D001789:Blood Group Antigens; D007048:I Blood-Group System