Effect of gastrin on the exocrine pancreas. A review.
Studies in animals demonstrate a gastric hormonal phase of pancreatic exocrine secretion. Endogenous or exogenous gastrin causes a marked elevation in the pancreatic enzymes and a lesser increase in the pancreatic volume and bicarbonate. It is possible that these "gastrin" effects may be the basis of a "cephalic" phase of pancreatic secretion. These observations have been only partially confirmed in human subjects with and without the Zollinger-Ellison syndrome. The physiologic importance of these ecbolic actions as well as a possible trophic effect remains to be elucidated.
D000818:Animals; D001639:Bicarbonates / Q000378:metabolism; D002415:Cats; D004285:Dogs; D004435:Eating; D005402:Fistula; D005755:Gastrins / Q000502:physiology*; D006801:Humans; D010179:Pancreas / Q000187:drug effects / Q000201:enzymology / Q000294:innervation / Q000378:metabolism*; D010418:Pentagastrin / Q000494:pharmacology; D051381:Rats; D013270:Stomach / Q000294:innervation; D014357:Trypsin / Q000378:metabolism; D014628:Vagotomy; D014630:Vagus Nerve / Q000502:physiology; D015043:Zollinger-Ellison Syndrome / Q000503:physiopathology
D001639:Bicarbonates; D005755:Gastrins; D014357:Trypsin; D010418:Pentagastrin