title: Reactions of cysteine, its derivatives, glutathione coenzyme A, and dihydrolipoic acid with isothiocyanates.
abstract: Isothiocyanates react with deprotonated SH groups of investigated compounds to give the esters of N-monosubstituted dithiocarbamic acid. In the presence of the SH and NH2 groups (Cys, GSH), isothiocyanates react primarily with the SH groups. The reactions are dependent on the pKa SH values.
mesh_terms: D055598:Chemical Phenomena; D002621:Chemistry; D003065:Coenzyme A; D003545:Cysteine; D005978:Glutathione; D007700:Kinetics; D013438:Sulfhydryl Compounds; D008063:Thioctic Acid / Q000031:analogs & derivatives*; D013861:Thiocyanates
chemical_list: D013438:Sulfhydryl Compounds; D013861:Thiocyanates; D008063:Thioctic Acid; D005978:Glutathione; D003545:Cysteine; D003065:Coenzyme A