Posttransplant hypersplenism.
Posttransplant hypersplenism, manifested by leukopenia and azathioprine intolerance, can be diagnosed with a high degree of accuracy and promptly reversed by emergency splenectomy. Functioning cadaver kidney homograft survival rates in patients undergoing posttransplant splenectomy are equal to that of patients undergoing pretransplant splenectomy and are statistically superior (p less than 0.01) to recipients who have never had their spleens removed. However, mortality (21%) for posttransplant splenectomy is excessively high when compared to our mortality (1.3%) for pretransplant splenectomy.
D001379:Azathioprine / Q000627:therapeutic use; D004361:Drug Tolerance; D006085:Graft Survival; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods; D007668:Kidney / Q000276:immunology; D016030:Kidney Transplantation; D007958:Leukocyte Count; D013156:Splenectomy; D013163:Splenomegaly / Q000601:surgery*; D013997:Time Factors; D014184:Transplantation, Homologous
D006680:HLA Antigens; D001379:Azathioprine