Alcoholic liver damage is provoked by 4-methylpyrazole, which prolongs the influence of ethanol but reduces acetaldehyde levels.
Rats chronically fed ethanol developed liver injury only if they also received low doses of the alcohol dehydrogenase inhibitor, 4-methylpyrazole, suggesting that the consistency of the influence of ethanol and its metabolism, rather than the level of acetaldehyde or the degree of the metabolic effects, contributes to the pathogenesis of alcoholic liver damage.
D000079:Acetaldehyde / Q000097:blood*; D000818:Animals; D004347:Drug Interactions; D000431:Ethanol / Q000097:blood / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008108:Liver Diseases, Alcoholic / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D008297:Male; D011720:Pyrazoles / Q000494:pharmacology*; D051381:Rats
D011720:Pyrazoles; D000431:Ethanol; D000079:Acetaldehyde