Nutritional state and endotoxin fever of newborn rabbits.
At thermoneutral environments 6-10 day-old well-fed rabbits responded to 20 microgram/kg I.V. E. coli endotoxin with biphasic fever: temperature peaks at 60 and 120-150, and a transient fall between 60 and 90 min after endotoxin injection. In rabbits starved for 24 hours, and in runt rabbits body temperature did not rise, but a decline started 60 min after endotoxin administration, corresponding to the transient fall observed in well-fed animals and continuing until about the 100-120th min; thereafter body temperature tended to stabilize at the low level.
D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D000831:Animals, Newborn; D001831:Body Temperature / Q000187:drug effects; D001833:Body Temperature Regulation / Q000187:drug effects; D004731:Endotoxins / Q000633:toxicity*; D004926:Escherichia coli; D005334:Fever / Q000139:chemically induced*; D007275:Injections, Intravenous; D008070:Lipopolysaccharides / Q000633:toxicity*; D011817:Rabbits; D013217:Starvation
D004731:Endotoxins; D008070:Lipopolysaccharides