Lidoflazine and physical training in the treatment of stable angina pectoris.
An additive effect in the treatment of angina pectoris by combining lidoflazine and physical training was postulated. Twenty-four patients were randomly divided into placebo and drug groups and subsequently underwent a 6-month physical training program. The drug group had a significantly greater reduction in submaximal heart rate than the placebo group. Similar improvements in symptom-limited exercise capacity were observed in both groups. Resting and maximal exercise coronary sinus blood flow and left ventricular oxygen consumption were not significantly changed with training in either group. Physical training and lidoflazine appear to influence exercise tolerance in the same manner.
D000787:Angina Pectoris / Q000175:diagnosis / Q000188:drug therapy / Q000628:therapy*; D001794:Blood Pressure; D006328:Cardiac Catheterization; D002986:Clinical Trials as Topic; D003326:Coronary Circulation; D004311:Double-Blind Method; D006339:Heart Rate; D006801:Humans; D008013:Lidoflazine / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010806:Physical Education and Training; D005082:Physical Exertion; D010809:Physical Fitness; D010879:Piperazines / Q000627:therapeutic use*; D010919:Placebos
D010879:Piperazines; D010919:Placebos; D008013:Lidoflazine