Estimation of haplotype frequency and linkage disequilibrium parameter in the HLA system.
Conventional formulae currently employed were extended to calculate the haplotype frequency and the corresponding variance for an arbitrary number (n) of loci when unrelated individuals were investigated. A formula is presented for the variance for the degree of three locus linkage disequilibrium.
D002874:Chromosome Mapping; D003201:Computers; D005787:Gene Frequency; D008040:Genetic Linkage; D005821:Genetic Techniques; D006680:HLA Antigens; D006801:Humans
D006680:HLA Antigens