title: Enhancement and suppression in production of IgM-antibody in mice treated with purified saponins.
abstract: Effects of purified saponins on antibody production against SRBC antigen were investigated in adult mice by using the direct hemolytic plaque technique of Cunningham and Szenberg. Intravenous injection of ginsenoside-Rb1, -Rc, senegin-III, -IV or platycodin-D caused increase in antibody-producing cells. However, the same treatment with ophiopogonin-D, ginsenoside-Rd or glycoside-H2 suppressed antibody production. Immuno-suppression due to the latter three substances seemed not to be associated with cytocidal effect. Ophiopogonin-B and platycodin-C had no effects.
mesh_terms: D000818:Animals; D002452:Cell Count; D004912:Erythrocytes / Q000276:immunology; D006462:Hemolytic Plaque Technique; D007075:Immunoglobulin M / Q000096:biosynthesis*; D008297:Male; D051379:Mice; D012503:Saponins / Q000494:pharmacology* / Q000633:toxicity; D012756:Sheep / Q000276:immunology; D013154:Spleen / Q000166:cytology
chemical_list: D007075:Immunoglobulin M; D012503:Saponins