Expression of Fv-4r allele in hematopoietic cells from G mice resistant to Friend leukemia virus.
G mice carrying the Fv-4r resistant allele supported virus growth neither at an early nor a later (Kai et al., 1976) stage of infection with NB-tropic FLV. This resistance could not be abolished by treatment of G mice with cyclophosphamide or cortisone acetate. By bone-marrow or spleen-cell transplantation into irradiated mice, the resistan-e of G mice could be transferred to Fv-4-susceptible mice. Conversely, transfer of bone-marrow or spleen cells of Fv-4-susceptible mice rendered G mice susceptible. It could be concluded that, as assessed by the virus content in the spleen, helper LLV grows mainly in radiosensitive, bone-marrow-derived cells, and the Fv-4 gene is expressed in these cells.
D000483:Alleles; D000818:Animals; D016026:Bone Marrow Transplantation; D003348:Cortisone / Q000494:pharmacology; D003520:Cyclophosphamide / Q000494:pharmacology; D005260:Female; D005622:Friend murine leukemia virus / Q000254:growth & development / Q000302:isolation & purification; D006412:Hematopoietic Stem Cells / Q000648:ultrastructure*; D007942:Leukemia, Experimental / Q000235:genetics* / Q000276:immunology / Q000382:microbiology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D011828:Radiation Chimera; D013154:Spleen / Q000382:microbiology / Q000637:transplantation; D013163:Splenomegaly / Q000209:etiology; D014184:Transplantation, Homologous
D003520:Cyclophosphamide; D003348:Cortisone