Inhibition by itaconate of growth of methylotrophic bacteria.
The effects of the isocitrate lyase-directed growth inhibitor itaconate on the growth of certain methylotrophic organisms was investigated. It was found that growth of those organisms possessing the Icl(+)-serine pathway of one-carbon metabolism was inhibited during growth on methylamine and on acetate, but not on glucose. Organisms possessing the Icl(-)-serine pathway pathway were unaffected. Organism PAR, an Icl(-)-serine pathway type, was not specifically inhibited during growth on acetate. This finding further substantiates previous reports of the lack of isocitrate lyase in this organism, indicating a totally new pathway for acetate assimilation.
D000085:Acetates / Q000378:metabolism; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D007522:Isocitrate Lyase / Q000037:antagonists & inhibitors; D008744:Methylamines / Q000378:metabolism; D011549:Pseudomonas / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D013386:Succinates / Q000378:metabolism / Q000494:pharmacology*
D000085:Acetates; D008744:Methylamines; D013386:Succinates; D007522:Isocitrate Lyase; D005947:Glucose