Recombinogenicity and mutagenicity of saccharin in Saccharomyces cerevisiae.
Diploid yeast grown in the presence of a commercial lot of saccharin exhibited reproducible, dose-dependent increases in intergenic and intragenic recombination, and mutation. Cells grew to nearly the same titer in media without saccharin and containing 2 or 20 mg saccharin/ml, although cell viability was somewhat reduced in saccharin-containing media. At the high test dose of 100 mg/ml, titers and cell viability were more markedly lowered. Differences between this study and previous (negative) tests of saccharin in yeast are described.
D004305:Dose-Response Relationship, Drug; D008938:Mitosis; D009154:Mutation / Q000187:drug effects*; D011995:Recombination, Genetic / Q000187:drug effects*; D012439:Saccharin / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000254:growth & development
D012439:Saccharin