title: Cephalosporin derivatives with 2- and 4-pyridone groups at carbon-3.
abstract: Two compounds, analogues of cephalexin with 2- and 4-pyridone groups at C-3, were prepared. Biological evaluation found the compounds to exhibit activity against Gram-positive and Gram-negative organisms in vitro and in vivo. The compounds were only active in vivo on subcutaneous administration.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002506:Cephalexin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use; D007279:Injections, Subcutaneous; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D013290:Streptococcal Infections / Q000188:drug therapy; D013297:Streptococcus pyogenes
chemical_list: D002506:Cephalexin