Objective and subjective assessment of ephedrine combinations in asthmatic outpatients.
11 asthmatic outpatients were treated with placebo, ephedrine + theophylline + hydroxyzine, ephedrine + theophylline, and ephedrine + hydroxyzine, orally t.i.d. for 4 days each in random order. Both objective (PEF rates) and subjective (ranking list) assessments demonstrated the efficacy of the triple combination over placebo. The combination of two drugs proved objectively or subjectively somewhat less acceptable.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000553:Ambulatory Care; D001249:Asthma / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004338:Drug Combinations; D004809:Ephedrine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006919:Hydroxyzine / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010366:Peak Expiratory Flow Rate; D010919:Placebos; D013806:Theophylline / Q000627:therapeutic use*
D004338:Drug Combinations; D010919:Placebos; D006919:Hydroxyzine; D013806:Theophylline; D004809:Ephedrine