Prejudices in pharmacology and pharmacotherapy: reserpine as a model for experimental research in depression.
The choice of reserpine as practically the sole model substance used in research in depression over two decades was not dictated by rational considerations alone: hypothetical notions, prospects of the rapid realization of experimental research aims and the fascination of the exotic origin of this "natural" drug made a significant contribution.
D002395:Catecholamines / Q000378:metabolism; D003863:Depression / Q000139:chemically induced*; D004195:Disease Models, Animal; D049673:History, 20th Century; D006801:Humans; D011600:Psychopharmacology / Q000379:methods*; D012107:Research Design; D012110:Reserpine / Q000266:history / Q000494:pharmacology*
D002395:Catecholamines; D012110:Reserpine