[Efficacy of the per os immunization and reimmunization of man with staphylococcal anatoxin].
By double immunization of 72 persons and single reimmunization of 38 persons per os with tablets containing 100 BU of purified concentrated staphylococcus toxoid (PCST) it was revealed that this immunization was harmless and the immunological response was adequate. The tablets were intended for application through the oral mucosa (oral) or the intestinal tract (enteral); the immunological response depended on the dose of the preparation and the scheme of administration. A high sensitization of healthy persons examined to staphylococcus was found. There was a tendency to reduction of hypersensitivity after the immunization with staphylococcus toxoid (examination in 6 months) and activation of reactions after the antigen administration (examination in 14 days).
D000284:Administration, Oral; D000328:Adult; D000992:Antitoxins / Q000032:analysis; D002986:Clinical Trials as Topic; D004306:Dose-Response Relationship, Immunologic; D004341:Drug Evaluation; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology; D007114:Immunization; D007117:Immunization, Secondary; D008875:Middle Aged; D013208:Staphylococcal Toxoid / Q000008:administration & dosage*; D013607:Tablets; D013608:Tablets, Enteric-Coated; D013997:Time Factors
D000992:Antitoxins; D013208:Staphylococcal Toxoid; D013607:Tablets; D013608:Tablets, Enteric-Coated
Effektivnost' immunizatsii i reimmunizatsii liudeĭ per os stafilokokkovym anatoksinom.