title: Vitamin C prophylaxis in marine recruits.
abstract: A prospective, randomized, double-blind study was carried out to determine whether vitamin C prophylaxis, 2.0 g/day, vs placebo prophylaxis would reduce the incidence or morbidity of the common cold and other respiratory illnesses in 674 marine recruits during an eight-week period. Whole-blood ascorbic acid levels measured six weeks after initiation of the study were significantly higher in the vitamin C group. There was no difference between the two groups in the incidence or duration of colds. The vitamin C group rated their colds as being less severe, but this was not reflected in different symptom complexes or in fewer sick-call visits or training days lost. This study and the literature do not support the prophylactic use of vitamin C to prevent the common cold.
mesh_terms: D001205:Ascorbic Acid / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003139:Common Cold / Q000517:prevention & control*; D004311:Double-Blind Method; D004341:Drug Evaluation; D006801:Humans; D008297:Male; D009326:Naval Medicine
chemical_list: D001205:Ascorbic Acid