title: Interaction of topical and oral timolol in glaucoma.
abstract: The interaction of oral and topical timolol maleate was studied in patients with open-angle glaucoma. The oral and topical preparations given separately produced a significant and comparable reduction of the intraocular pressure, but no additive effect was observed when both preparations were given together. Pulse- and blood pressure-lowering effects of oral timolol were not enhanced by the application of topical timolol. These systemic effects were not found in those patients using topical timolol alone.
mesh_terms: D000284:Administration, Oral; D000287:Administration, Topical; D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005901:Glaucoma / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008875:Middle Aged; D011412:Propanolamines / Q000627:therapeutic use*; D011674:Pulse / Q000187:drug effects; D013999:Timolol / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D011412:Propanolamines; D013999:Timolol