title: Breathing responses of unanesthetized man and guinea pigs to increased transrespiratory pressure.
abstract: We compared the breathing responses of unanesthetized men and guinea pigs to externally imposed shifts in lung volume produced by steady pressures applied to the body surface while the mouth remained near atmospheric pressure. Lung inflation caused no consistent or significant changes either in frequency or end-tidal CO2 in the three men. In contrast, during lung inflation the guinea pigs breathed at low frequencies and smaller tidal volumes and showed consistent increases in arterial PCO2 lasting up to 10 min. The changes seen immediately on application of pressure, namely apneic periods followed by breathing in which inspiratory duration was shortened while expiratory duration was substantially increased, indicates that conscious guinea pigs have active inflation reflexes. We concluded that the reflex responses rather than mechanical factors probably account for the underventilation in the guinea pigs and that guinea pigs are not nearly as well equipped as is man to defend gas exchange in the face of nonmetabolic shifts in lung volume.
mesh_terms: D000818:Animals; D006168:Guinea Pigs; D006801:Humans; D008297:Male; D011175:Positive-Pressure Respiration; D011187:Posture; D012018:Reflex / Q000502:physiology*; D012119:Respiration; D013045:Species Specificity; D013990:Tidal Volume; D013997:Time Factors