Report on carcinogenesis bioassay of 1,2-dibromoethane (EDB).
In a carcinogenesis bioassay of the brominated hydrocarbon 1,2-dibromoethane (also called ethylene dibromide or EDB), a gasoline and antiknock additive and soil and grain fumigant, oral administration by stomach tube caused cancers in rats and mice. In both sexes of both species, EDB induced squamous cell carcinomas of the forestomach. Blood vessel cancers in male rats, liver cancers in female rats, and lung cancers in male and female mice also were attributed to EDB dosage.
D000818:Animals; D001681:Biological Assay; D004305:Dose-Response Relationship, Drug; D015946:Ethylene Dibromide / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006842:Hydrocarbons, Brominated / Q000009:adverse effects*; D008297:Male; D051379:Mice; D009369:Neoplasms / Q000139:chemically induced*; D051381:Rats
D006842:Hydrocarbons, Brominated; D015946:Ethylene Dibromide