Glycophorin A as a cell surface marker of early erythroid differentiation in acute leukemia.
We show here that the leukemic blast cells from three patients of a total of 15 subsequently diagnosed as having acute leukemia express on their surface the major red cell sialoglycoprotein, glycophorin A (GP-A). This was demonstrated (1) by indirect immunofluorescence using rabbit anti GP-A anti-serum and (2) by immune precipitation of GP-A from surface radiolabelled leukemic cells. Since GP-A is exclusively present on erythroid cells and their precursors, these findings indicate that a higher proportion of the blast leukemias than previously recognized show features of early erythroid differentiation.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002454:Cell Differentiation; D004900:Erythroblasts / Q000032:analysis; D004910:Erythrocyte Membrane / Q000032:analysis*; D004912:Erythrocytes / Q000032:analysis*; D005260:Female; D005455:Fluorescent Antibody Technique; D006021:Glycophorins / Q000032:analysis*; D006801:Humans; D007945:Leukemia, Lymphoid / Q000097:blood*; D015470:Leukemia, Myeloid, Acute / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012795:Sialoglycoproteins / Q000032:analysis*
D006021:Glycophorins; D012795:Sialoglycoproteins