Parapsoriasis with hyper-IgE.
A 56-year-old black man had generalized chronic dermatitis for two years before parapsoriasis en plaque (large type) with hyper-IgE (12,000-22,000 ng/ml) was diagnosed. Lymphocyte cultures showed decreased response to mitogens. Direct immunofluorescence of involved skin showed epidermal and dermal mast cells with bound IgE. Parapsoriasis with hyper-IgE may represent a form of "hypersensitive immunosurveillance" allowing a patient to reject a clone of malignant cells and retard transformation from a benign state (parapsoriasis) to a malignant state (mycosis fungoides).
D005455:Fluorescent Antibody Technique; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis*; D007136:Immunoglobulins / Q000032:analysis; D007158:Immunologic Techniques; D008297:Male; D008407:Mast Cells / Q000276:immunology; D008875:Middle Aged; D010267:Parapsoriasis / Q000175:diagnosis / Q000276:immunology*; D012397:Rosette Formation; D012882:Skin Tests
D007136:Immunoglobulins; D007073:Immunoglobulin E