In vivo bound pemphigus antibodies in a stillborn infant. Passive intrauterine transfer of pemphigus vulgaris?
Pemphigus vulgaris developed in a 23-year-old woman during the first trimester of pregnancy. In the 33d week she had a stillbirth of a female child who showed extensive skin lesions clinically suggestive of pemphigus. The application of direct immunofluorescence staining to skin tissue sections showed deposition of IgG in the intercellular spaces of the epidermis of both mother and child. Our findings raise the possibility of transplacentar passage of pemphigus antibody, which may have been responsible for the fetal skin lesions.
D000328:Adult; D000906:Antibodies / Q000032:analysis*; D001706:Biopsy; D003176:Complement C3; D005260:Female; D005313:Fetal Death / Q000276:immunology* / Q000473:pathology; D005315:Fetal Diseases / Q000276:immunology / Q000473:pathology; D005455:Fluorescent Antibody Technique; D006801:Humans; D007116:Immunization, Passive; D007074:Immunoglobulin G; D010392:Pemphigus / Q000276:immunology* / Q000473:pathology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology / Q000473:pathology; D012867:Skin / Q000473:pathology
D000906:Antibodies; D003176:Complement C3; D007074:Immunoglobulin G