IgE in patients with glomerulonephritis and minimal-change nephrotic syndrome.
Serum levels of IgE were studied in 30 children with minimal-change nephrotic syndrome and 32 children with mesangioproliferative glomerulonephritis during different stages of the disease and treatment. In addition, tissue obtained by renal biopsy was investigated by immunofluorescence histology; no deposits of IgE could be found. The serum IgE levels, however, were increased, particularly in patients with minimal-change nephrotic syndrome. It is concluded that IgE does not play a pathogenic role in the development of the renal disease, but that increased IgE levels are an indication of a disturbance of the immune system.
D000293:Adolescent; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D005260:Female; D005455:Fluorescent Antibody Technique; D005921:Glomerulonephritis / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis*; D007668:Kidney / Q000473:pathology; D008297:Male; D009402:Nephrosis, Lipoid / Q000276:immunology* / Q000473:pathology; D009404:Nephrotic Syndrome / Q000276:immunology* / Q000473:pathology
D007073:Immunoglobulin E