Characterization of furosemide-induced activation of the renal prostaglandin system.
A detailed time course of changes in plasma renin activity (PRA), urinary prostaglandin (PG) E2, PGF2 alpha, thromboxane (TX) B2 and sodium excretion rates following furosemide was obtained in 7 women. PRA increased within the first 15 min and remained elevated all through the experiment. PGE2, PGF2 alpha, TXB2 and sodium increased simultaneously, reached a peak between 15 and 45 min after furosemide and declined thereafter. It is concluded that furosemide induces a generalized activation of the renal PG system temporally related to the increase of renin release and natriuresis.
D000328:Adult; D005260:Female; D005665:Furosemide / Q000494:pharmacology*; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D011453:Prostaglandins / Q000502:physiology* / Q000652:urine; D012083:Renin / Q000097:blood; D012964:Sodium / Q000652:urine; D013929:Thromboxane B2 / Q000652:urine; D013997:Time Factors
D011453:Prostaglandins; D013929:Thromboxane B2; D005665:Furosemide; D012964:Sodium; D012083:Renin