title: In vitro activity of sulphonamides as a function of their molar refractivity.
abstract: A significnat correlation has been found between the in vitro activity of 16 commonly employed sulphonamides and their molar refractivity. The molar refractivity has been shown to be a superior parameter for the description of the activity of sulphonamides than the sum of electronegativities of atoms making up a heterocyclic substituent in the sulphonamide molecule and molecular weight of the substituent.
mesh_terms: D001419:Bacteria / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008970:Molecular Weight; D012044:Regression Analysis; D013329:Structure-Activity Relationship; D013424:Sulfanilamides / Q000494:pharmacology; D013449:Sulfonamides / Q000494:pharmacology*
chemical_list: D013424:Sulfanilamides; D013449:Sulfonamides