Immunologic phenomena in herpes gestationis.
Immunofluorescence studies were performed in 12 cases of herpes gestations. Direct IF staining (performed in 10 of them) revealed a highly characteristic pattern, notably 1) Constantly BMZ deposits of complement component C3, 2) In most biopsy specimens also C4 and C5, 3) Deposits of C4, C5, properdin and IgG variable in different specimens of given patients. About half of the specimens examined contained properdin and about one third stained for IgG, 4) Findings of IgM, IgA, IgD and IgE were consistently negative, 5) Serum findings of BMZ antibodies in given cases were variable. In two cases circulating BMZ antibodies were detected in one of the samples examined. On the base of these findings it seems that HG is related to BP.
D001327:Autoimmune Diseases / Q000276:immunology; D001485:Basement Membrane / Q000276:immunology; D003176:Complement C3 / Q000032:analysis; D003165:Complement System Proteins / Q000032:analysis; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000276:immunology; D006559:Pemphigoid Gestationis / Q000276:immunology*; D010392:Pemphigus / Q000276:immunology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology*; D011414:Properdin / Q000032:analysis; D012872:Skin Diseases, Vesiculobullous / Q000276:immunology*
D003176:Complement C3; D007074:Immunoglobulin G; D007136:Immunoglobulins; D011414:Properdin; D003165:Complement System Proteins