Factors responsible for the functional pattern of cadaveric kidneys stored up to 25 hours before transplantation.
The functional outcome after the transplantation of 97 cadaveric kidneys stored up to 25 hours with simple hypothermia was analysed in relation to age of donor, extent of pre-agonal kidney damage, the length of warm, cold and standardised ischaemic times and the presence of multiple renal arteries. Analysis of various factors showed that the most important for function after transplantation were pre-agonal anoxic damage and the ratio of the cold/warm ischaemia time. Based on that observation, a diagram has been proposed which allows calculation of the safe cold storage time after retrieval of the kidney.
D000293:Adolescent; D000328:Adult; D002102:Cadaver; D006801:Humans; D007022:Hypotension / Q000503:physiopathology; D007511:Ischemia / Q000503:physiopathology; D007668:Kidney / Q000098:blood supply; D016030:Kidney Transplantation; D007683:Kidney Tubular Necrosis, Acute / Q000473:pathology; D008875:Middle Aged; D011309:Preservation, Biological; D012077:Renal Artery / Q000473:pathology; D013696:Temperature; D013997:Time Factors