Regulation of differentiation in transformed erythroid cells.
Murine erythroleukemia cells provide a model for the study of erythropoietic differentiation uncoupled from the normal requirement for erythropoietin for cell proliferation. Evidence is presented which suggests that differentiation-inducing chemicals may have a number of cellular sites of action, including effects at the plasma membrane and on chromatin, but a common pathway may include a transient delay of the cell cycle in G1, alterations in chromatin structure, and the expression of a complex pattern of gene transcription responsible for the program of differentiation.
D000081:Acetamides / Q000494:pharmacology; D000818:Animals; D002454:Cell Differentiation; D002478:Cells, Cultured; D004912:Erythrocytes / Q000166:cytology* / Q000378:metabolism; D005622:Friend murine leukemia virus; D006454:Hemoglobins / Q000096:biosynthesis; D004915:Leukemia, Erythroblastic, Acute / Q000097:blood; D051379:Mice; D008811:Mice, Inbred DBA; D013997:Time Factors
D000081:Acetamides; D006454:Hemoglobins