Bullous dermatosis and systemic lupus erythematosus in a 15-year-old boy.
A 15-year-old boy had a bullous eruption suggestive of bullous pemphigoid and established systemic lupus erythematosus (SLE). Direct immunofluorescence studies of the bullae and adjacent skin revealed the linear deposition of IgG and complement localized to the basement membrane zone. Indirect immunofluorescence examination of the serum failed to reveal circulating basement membrane zone antibodies. The differential diagnosis of the bullous eruption is reviewed, and the problem of diagnosis in cases of coexistent bullous disease and SLE is discussed.
D000293:Adolescent; D001485:Basement Membrane / Q000276:immunology; D001706:Biopsy; D003165:Complement System Proteins / Q000032:analysis; D005921:Glomerulonephritis / Q000209:etiology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D011241:Prednisone / Q000627:therapeutic use; D012867:Skin / Q000473:pathology; D012872:Skin Diseases, Vesiculobullous / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy
D007074:Immunoglobulin G; D003165:Complement System Proteins; D011241:Prednisone