The effect of luteinizing hormone releasing hormone (LH-RH) and oestrogen on RNA synthesis in anterior pituitary and different brain regions of rats.
Oestradiol-17beta caused a marked reduction of RNA content in the cortex, hippocampus, brain stem, hypothalamus and RNA synthesis in the pituitary. LH-RH had facilitatory effect on the cortical and inhibitory influence on the hypothalamic RNA synthesis in vitro, and suppressed the pituitary RNA synthesis both in vivo and in vitro. The possible regulatory role of the LH-RH in the nucleic acid metabolism in discussed.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D001933:Brain Stem / Q000378:metabolism; D002369:Castration; D002540:Cerebral Cortex / Q000378:metabolism; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology*; D006624:Hippocampus / Q000378:metabolism; D007031:Hypothalamus / Q000378:metabolism; D010903:Pituitary Gland, Anterior / Q000187:drug effects / Q000378:metabolism*; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D014529:Uridine / Q000378:metabolism
D007987:Gonadotropin-Releasing Hormone; D004958:Estradiol; D012313:RNA; D014529:Uridine