title: Pagetoid reticulosis. A further case report with a review of the literature.
abstract: A further case of pagetoid reticulosis (PR) was studied, and the findings were compared with 18 previous case reports in the literature. There seem to be two variants: The generalized type (Ketron-Goodman) with disseminated lesions and a poor prognosis, and the localized type (Woringer-Kolopp), with a single lesion usually located on the extremities with a good prognosis (if the lesion can be totally cleared by excision or highdose-radiation). The basic criterion of diagnosis is a very strong cellular infiltrate within the epidermis, but usually weak in the upper dermis. The etiology of PR remains unclear: In some cases a T-cell lymphoma seems a likely interpretation. In others, epidermal infiltrating cells are not typically lymphoid, but remain morphologically unclassifiable.
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007158:Immunologic Techniques; D008206:Lymphatic Diseases / Q000648:ultrastructure*; D009182:Mycosis Fungoides / Q000648:ultrastructure*; D012867:Skin / Q000378:metabolism / Q000648:ultrastructure*; D012878:Skin Neoplasms / Q000378:metabolism / Q000648:ultrastructure*; D013577:Syndrome