title: Nonepithelial tumors of the nasal cavity, paranasal sinuses and nasopharynx: a clinicopathologic study. X. Malignant lymphomas.
abstract: In our series of 256 nonepithelial tumors involving the nasal cavity, paranasal sinuses and nasopharynx, 21 were apparently primary malignant lymphomas, including 17 ordinary lymphomas and 4 cases of "midline malignant reticulosis." Of the 15 patients who had ordinary lymphomas and had adequate follow-up, 8 died of lymphoma, 4 were living with disseminated disease, 1 died of other causes with persistent lymphoma and only 2 (13%) had no evidence of recurrence at 8 and 9 years after diagnosis. The tumor was controlled in its primary site by radiotherapy in 13 of 14 patients; however, all but 2 of these patients eventually developed disseminated disease. Of the 3 patients who had midline malignant reticulosis (MMR) and had adequate follow-up, all died of disease. MMR represents an unusual variant of malignant lymphoma and often produces the clinical picture of lethal midline granuloma.
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006103:Granuloma, Lethal Midline / Q000473:pathology; D006801:Humans; D008206:Lymphatic Diseases / Q000473:pathology / Q000628:therapy; D008223:Lymphoma / Q000473:pathology* / Q000628:therapy; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009296:Nasal Cavity; D009303:Nasopharyngeal Neoplasms / Q000473:pathology* / Q000628:therapy; D009669:Nose Neoplasms / Q000473:pathology* / Q000628:therapy; D010255:Paranasal Sinus Neoplasms / Q000473:pathology* / Q000628:therapy; D011379:Prognosis