Reflex adrenergic gastrin release evoked by unloading of carotid baroreceptors in cats.
Gastric acid and pepsin output in response to 0.10 and 6.0 microgram . kg-1h-1 of pentagastrin response to complete elimination of the carotid baroreceptor discharge by cutting the bilateral sinus nerves. Such unloading of the baroreceptors simulates a blood pressure drop to 50--60 mmHg, resulting in a pronounced reflex increase in the activity of the sympatho-adrenal system. Cutting the sinus nerves caused an increased level of immuno-reactive gastrin in the portal plasma, and this elevated gastrin concentration was virtually  extinguished by bilateral adrenalectomy. We conclude that the carotid baroreceptors can influence the gastrin release by a reflex adjustment of the release of adrenal catecholamines.
D000818:Animals; D000941:Antigens; D001794:Blood Pressure; D002395:Catecholamines / Q000378:metabolism; D002415:Cats; D005750:Gastric Juice / Q000378:metabolism; D005755:Gastrins / Q000097:blood / Q000378:metabolism*; D010418:Pentagastrin / Q000494:pharmacology; D010434:Pepsin A / Q000378:metabolism; D011311:Pressoreceptors / Q000502:physiology*; D012018:Reflex / Q000502:physiology*; D012636:Secretory Rate / Q000187:drug effects; D013564:Sympathetic Nervous System / Q000502:physiology
D000941:Antigens; D002395:Catecholamines; D005755:Gastrins; D010434:Pepsin A; D010418:Pentagastrin