Time factors in total body irradiation.
The role of time dose factors in the irradiation effect of the bone marrow has been investigated in mice by assessing the lethal dose 50% as a function of fraction number and dose rate. It is compared to the time dose effect in intestinal mucosa and lung, considered as critical tissues, for discussing the differential effect between these tissues.
D000818:Animals; D001853:Bone Marrow / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D006412:Hematopoietic Stem Cells / Q000528:radiation effects; D007413:Intestinal Mucosa / Q000528:radiation effects; D008168:Lung / Q000528:radiation effects; D051379:Mice; D013997:Time Factors