[Effect of alpha-mercaptopropionylglycine (alpha-MPG) and sodium dipropylacetate (DPA) on antibody formation (III) (author's transl)].
Mechanisms of the immunostimulative activity. In the present paper, an investigation was carried out to clarify the mechanisms regarding immunostimulative activity of alpha-MPG and DPA. Phagocytosis of peritoneal macrophage was enhanced by high concentration of alpha-MPG, but was unaffected with DPA in vitro. Mice were immunized with an i.v. injection of sheep erythrocytes and 3 days later spleen cells were isolated and incubated with alpha-MPG and DPA FOR 24 HR. Although neither drug affected the number of recovered and living cells, hemolytic plaque forming cells were increased with alpha-MPG and there was a tendency to increase with DPA. Phytohemagglutinin-P and/or lipopolysacchride E. coli-induced blast formation was not reinforced by either drug in spleen cells of mice, and no mitogenic activity was found in the spleen cells. In the early stage of immuno-response to polyvinylpyrrolidone as a T cell independent antigen, the titre of antibody showed no increase after either drug. alpha MPG and DPA apparently act as potentiators in antigen modifications of macrophages.
D000603:Amino Acids, Sulfur / Q000494:pharmacology*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D008213:Lymphocyte Activation / Q000187:drug effects; D008264:Macrophages / Q000276:immunology; D008297:Male; D051379:Mice; D010587:Phagocytosis / Q000187:drug effects; D010835:Phytohemagglutinins / Q000494:pharmacology; D011205:Povidone / Q000276:immunology; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013268:Stimulation, Chemical; D008625:Tiopronin / Q000494:pharmacology*; D014635:Valproic Acid / Q000494:pharmacology*
D000603:Amino Acids, Sulfur; D010835:Phytohemagglutinins; D014635:Valproic Acid; D008625:Tiopronin; D011205:Povidone