Delayed rejection of cardiac xenografts in C6-deficient rabbits.
Puppy hearts were engrafted to C6-deficient rabbits, and also to complement-sufficient animals in order to determine the influence of the sixth component of complement on xenograft rejection. Delayed rejection was observed in the puppy hearts engrafted to the C6-deficient animals indicating that complement sufficiency of C6 is required for hyperacute xenograft rejection.
D000818:Animals; D001783:Blood Flow Velocity; D003183:Complement C6 / Q000172:deficiency*; D003326:Coronary Circulation; D004285:Dogs; D006084:Graft Rejection; D016027:Heart Transplantation; D009200:Myocardial Contraction; D011817:Rabbits; D013997:Time Factors; D014183:Transplantation, Heterologous
D003183:Complement C6