[Immunostimulating activity of certain subcellular fractions of Escherichia coli O138:K81:H19].
A 24-hour culture of Escherichia coli 0138:K81:H19 was used to isolate a soluble cytoplasmic fraction, an O antigen, and an unsolube cell ingredient. Their immunogenic action was followed up through subcutaneous vaccination of mice and the production of humoral antibodies in rabbits. It was found that the cytoplasmic ingredient was a slightly toxic protective antigen forming considerable immunity in mice and a comparatively high titer of antibodies in rabbit sera. The unsoluble cell ingredient and the O antigen proved comparatively toxic and did not produce favourable immune response. Discussed in the use of the cytoplasmic ingredient as a vaccine as well as the type of the immunoglobulins produced.
D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D001428:Bacterial Vaccines / Q000276:immunology* / Q000633:toxicity; D004926:Escherichia coli / Q000276:immunology*; D004927:Escherichia coli Infections / Q000517:prevention & control*; D051379:Mice; D011817:Rabbits; D013347:Subcellular Fractions / Q000276:immunology; D014611:Vaccination
D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines
Imunostimulirashta aktivnost na niakoi subkletuchni fraktsii ot Escherichia coli O138:K81:H19.