The role of macrophages in leprosy as studied by protein synthesis of macrophages from resistant and susceptible hosts--a mouse and human study.
3H-leucine uptake by macrophages from swiss white and C57BL mice before and after M. leprae infection was studied. A depression in 3H-leucine uptake after infection was observed only in swiss white mice. 3H-leucine uptake was also studied in blood derived macrophages from normals, and LL and TT patients. A depression was obtained in 3H-leucine uptake after M. leprae infection in macrophages from LL patients.
D000818:Animals; D006801:Humans; D007111:Immunity, Cellular; D066298:In Vitro Techniques; D007918:Leprosy / Q000276:immunology / Q000378:metabolism* / Q000382:microbiology; D007930:Leucine / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism* / Q000382:microbiology; D051379:Mice; D008810:Mice, Inbred C57BL; D009166:Mycobacterium leprae / Q000302:isolation & purification; D009167:Mycobacterium lepraemurium / Q000302:isolation & purification
D007930:Leucine