title: Mode of action of colicins Ia, E1 and K.
abstract: Addition of colicins Ia, E1 or K to sensitive Escherichia coli leads to inhibition of macromolecular synthesis and an uncoupling of electron transport from active transport. Recent results indicate that these colicins affect energy metabolism by interacting directly with the cytoplasmic membrane. This results in a transmembrane flow of ions leading to membrane depolarization. It is proposed that the function of the outer membrane colicin receptor is to mediate access of the colicin molecule to the cytoplasmic membrane.
mesh_terms: D001693:Biological Transport, Active / Q000187:drug effects; D002258:Carbonyl Cyanide m-Chlorophenyl Hydrazone / Q000494:pharmacology; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D003087:Colicins / Q000378:metabolism / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism; D008081:Liposomes / Q000378:metabolism; D008564:Membrane Potentials / Q000187:drug effects; D008954:Models, Biological; D011955:Receptors, Drug / Q000378:metabolism
chemical_list: D003087:Colicins; D008081:Liposomes; D011955:Receptors, Drug; D002258:Carbonyl Cyanide m-Chlorophenyl Hydrazone