title: Identification of a lobe in the adult human pancreas rich in pancreatic polypeptide.
abstract: Systematic sampling of human necropsy pancreases has revealed that pancreatic polypeptide (PP) cells are not distributed equally in the gland. PP-cells are the most abundant cell type in the posterior part of the pancreatic head while they are scarce or absent in the remainder of the gland. The PP-rich part of the head can be separated by blunt dissection from the pancreas as a discrete lobe. This lobe probably originates from the ventral pancreatic bud during embryogenesis. A quantitative study of the immunofluorescent endocrine cell types (insulin, glucagon, somatostatin and pancreatic polypeptide cells) in PP-rich and PP-poor regions of pancreases in 8 subjects with ages ranging from 33 fetal weeks to 80 years, showed that the proportions of the cell types were different in youngs and adults.
mesh_terms: D000328:Adult; D000368:Aged; D001344:Autopsy; D002648:Child; D005260:Female; D005333:Fetus; D005934:Glucagon / Q000032:analysis; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007328:Insulin / Q000032:analysis; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000032:analysis* / Q000473:pathology; D010191:Pancreatic Polypeptide / Q000032:analysis*; D011247:Pregnancy; D013004:Somatostatin / Q000032:analysis
chemical_list: D007328:Insulin; D013004:Somatostatin; D010191:Pancreatic Polypeptide; D005934:Glucagon