[Synthesis of beta, beta'-subunits of RNA-polymerase in E. coli cells starved for an essential amino acid].
The differential rate of RNA-polymerase beta,beta'-subunits synthesis in E. coli rel+ and rel- cells starved for an essential amino acid, i. e. leucine, is decreased. Inhibition of the rpo BC genes expression proceeds faster in the rel A strain. Guanosine tetraphosphate within the concentration range of 0,2--0,6 mM specifically inhibits lambda drifd18 DNA directed beta,beta'-subunits synthesis in vitro. rpo BC genes are believed to be subject to a weak "stringent control".
D012321:DNA-Directed RNA Polymerases / Q000096:biosynthesis*; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology*; D006159:Guanosine Tetraphosphate / Q000494:pharmacology; D007700:Kinetics; D007930:Leucine / Q000378:metabolism*; D046911:Macromolecular Substances; D009154:Mutation; D013045:Species Specificity; D014158:Transcription, Genetic
D046911:Macromolecular Substances; D006159:Guanosine Tetraphosphate; D012321:DNA-Directed RNA Polymerases; D007930:Leucine
Sintez beta, Beta'-sub'edinits RNK-polimerazy v kletkakh E. Coli pri defitsite neobkhodimoĭ aminokisloty.