Effects of trimeprazine and trimipramine on nocturnal scratching in patients with atopic eczema.
Twelve men with severe and long-standing atopic eczema were admitted to a double-blind trial to establish the effects of trimeprazine tartrate, trimipramine maleate, and placebo on nocturnal scratching. Neither of the drugs altered the likelihood of a scratching bout beginning in wakefulness or in any stage of sleep. However, both drugs, especially trimipramine, made sleep less broken, and the reduced time spent in stage 1 of sleep accounted for a modest reduction in the overall amount of scratching during the night.
D000328:Adult; D002986:Clinical Trials as Topic; D003984:Dibenzazepines / Q000627:therapeutic use*; D004311:Double-Blind Method; D004485:Eczema / Q000150:complications*; D006801:Humans; D008297:Male; D010919:Placebos; D011537:Pruritus / Q000188:drug therapy* / Q000209:etiology; D012894:Sleep Stages / Q000187:drug effects*; D014291:Trimeprazine / Q000494:pharmacology / Q000627:therapeutic use*; D014299:Trimipramine / Q000494:pharmacology / Q000627:therapeutic use*
D003984:Dibenzazepines; D010919:Placebos; D014299:Trimipramine; D014291:Trimeprazine