Effect of pimozide on the response of LH-RH in intact adult male rats.
The effect of Pimozide on serum and pituitary concentration of LH was studied in adult male intact rats. Also the release of LH under stimulation of exogenous LH-RH was measured. The treatment for 5 days with pimozide did not alter the serum LH levels, decreased the release of LH by exogenous LH-RH stimulation, and increased the pituitary LH concentration. These results would indicate that blocking the dopaminergic receptors alters pituitary LH release mechanism.
D000818:Animals; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology*; D007986:Luteinizing Hormone / Q000097:blood / Q000378:metabolism*; D008297:Male; D010868:Pimozide / Q000494:pharmacology*; D010902:Pituitary Gland / Q000378:metabolism; D051381:Rats
D010868:Pimozide; D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone