Mitochondrial, nuclear and smooth-muscle antibodies in intrahepatic cholestasis of pregnancy.
Serum mitochondrial, nuclear and smooth-muscle antibodies were assayed by the immunofluorescence method in a series of 42 patients with intrahepatic cholestasis of pregnancy and a control series of 15 normal pregnant subjects. None of the subjects examined had mitochondrial antibodies, and nuclear antibodies were only found in one patient with intrahepatic cholestasis of pregnancy. Smooth-muscle antibodies were noted altogether in four patients with intrahepatic cholestasis of pregnancy, in three at a titre of 1 : 40 and in one at 1 : 80; in two controls at titres of 1 : 20, and in two at 1 : 40. In the differential diagnosis of intrahepatic cholestasis of pregnancy the smooth-muscle antibodies particularly may be helpful in differentiating viral hepatitis and intrahepatic cholestasis of pregnancy.
D000293:Adolescent; D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis; D001323:Autoantibodies / Q000032:analysis; D001797:Blood Protein Electrophoresis; D001798:Blood Proteins / Q000032:analysis; D002779:Cholestasis / Q000175:diagnosis / Q000276:immunology*; D003937:Diagnosis, Differential; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D008928:Mitochondria / Q000276:immunology*; D009130:Muscle, Smooth / Q000276:immunology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis / Q000276:immunology*
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D001798:Blood Proteins