Immunotherapy of guinea pig line 10 hepatoma with nonliving BCG cells in aqueous medium.
Killed BCG cells suspended in 1.5% carboxymethylcellulose cured guinea pigs with established line 10 tumors in a high percentage of cases. The bacterial preparation of BCG in carboxymethylcellulose displayed a stronger tumor regressive activity and the process of healing was accelerated when endotoxin from a rough (Re) strain of Salmonella typhimurium was added to the BCG bacilli.
D000818:Animals; D001500:BCG Vaccine / Q000627:therapeutic use*; D001427:Bacterial Toxins / Q000627:therapeutic use; D002266:Carboxymethylcellulose Sodium / Q000627:therapeutic use; D004731:Endotoxins / Q000627:therapeutic use; D006168:Guinea Pigs; D008114:Liver Neoplasms, Experimental / Q000628:therapy*; D012486:Salmonella typhimurium
D001500:BCG Vaccine; D001427:Bacterial Toxins; D004731:Endotoxins; D002266:Carboxymethylcellulose Sodium