Mutagenic and colicine-inducing activity of two antioxidants: pyrogallol and purpurogallin.
The antioxidants pyrogallol and its oxidative derivative, purpurogallin, both induce colicine E2 as well as base substitution and frameshift mutations. Because of the bactericidal effect of purpurogallin, its mutagenicity could be best demonstrated by short-term exposure followed by dilution on the test plates. The colicine-inducing potential of purpurogallin was also observed when tested directly on the plates.
D000609:Aminoacridines / Q000494:pharmacology; D000818:Animals; D001567:Benzocycloheptenes / Q000494:pharmacology*; D001580:Benzopyrenes / Q000494:pharmacology; D003087:Colicins / Q000096:biosynthesis*; D008099:Liver / Q000378:metabolism; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology; D009154:Mutation / Q000187:drug effects*; D011748:Pyrogallol / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000378:metabolism
D000609:Aminoacridines; D001567:Benzocycloheptenes; D001580:Benzopyrenes; D003087:Colicins; D011748:Pyrogallol; D008769:Methylnitronitrosoguanidine; C026133:purpurogallin