Comparative study of mutagenic, inductive and transforming activities of ledakrin.
Mutagenic activity of Ledakrin in microbial testing as well as its inductive effect on the release of free phages in lysogenic bacteria were compared with its transforming ability in human cell system. It has been found that Ledakrin is highy mutagenic both without metabolic activation and when activated in vivo. Ledakrin induces the release of free phages in E. coli K12(lambda +), but does not transform human fibroblasts in cell cuture in vitro.
D000166:Acridines / Q000633:toxicity*; D000818:Animals; D001711:Biotransformation; D002471:Cell Transformation, Neoplastic; D004790:Enzyme Induction; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D051379:Mice; D009153:Mutagens; D009564:Nitracrine / Q000378:metabolism / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000187:drug effects
D000166:Acridines; D009153:Mutagens; D009564:Nitracrine