A mechanism for the hydroperoxide-mediated inactivation of prostacyclin synthetase.
Hydroxyl radical generation was demonstrated during heme-catalyzed decomposition of 15-hydroperoxy arachidonic acid. The hydroperoxide-mediated inactivation of prostacyclin synthetase seems to be related to the generation of this highly reactive species. A relationship between hydroperoxides and the hydroxyl radical may be important in the modulation of prostacyclin synthesis in diseased states.
D000818:Animals; D001095:Arachidonic Acids / Q000494:pharmacology*; D002417:Cattle; D003577:Cytochrome P-450 Enzyme System; D011464:Epoprostenol / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D005030:Ethylenes / Q000096:biosynthesis; D006454:Hemoglobins / Q000378:metabolism; D019746:Intramolecular Oxidoreductases; D008706:Methemoglobin / Q000378:metabolism; D010545:Peroxides / Q000494:pharmacology*; D011448:Prostaglandin Antagonists
D001095:Arachidonic Acids; D005030:Ethylenes; D006454:Hemoglobins; D010545:Peroxides; D011448:Prostaglandin Antagonists; D008706:Methemoglobin; D003577:Cytochrome P-450 Enzyme System; D011464:Epoprostenol; D019746:Intramolecular Oxidoreductases; C022461:prostacyclin synthetase