Miconazole prolongs murine skin graft survival.
The effects of miconazole, a broad spectrum anti-fungal compound, on the immune response was studied in mice. At the non-toxic dose of 300 mg/kg per day, there was minimal suppression of the antibody response to sheep red blood cells. In contrast, there was a marked prolongation of skin graft survival from 13.6 +/- 1.8 days (mean +/- s.d.) in untreated mice to 18.6 +/- 3.5 dyas in the treated group. Miconazole may be of use in clinical transplantation.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D006085:Graft Survival / Q000187:drug effects*; D007093:Imidazoles / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008825:Miconazole / Q000494:pharmacology*; D016038:Skin Transplantation; D013997:Time Factors; D014184:Transplantation, Homologous
D007093:Imidazoles; D008825:Miconazole