Prostaglandin-like substances in Propionibacterium acnes. III. Differential contractile effects on smooth muscle layers of the human utero-tubal junction.
The biological activity of a lipid fraction extracted from P. acnes was tested on isolated smooth muscle strips from the human utero-tubal junction. The bioassay experiments support the concept that prostaglandin-like substances (PLS) occur in P. acnes. However, in the bioassay system used, the effect of PLS was different from that of PGF2 alpha and PGI2 but similar, although not identical, to that of arachidonic acid and PGE2.
D011464:Epoprostenol / Q000494:pharmacology; D005260:Female; D006801:Humans; D011424:Propionibacterium / Q000032:analysis*; D011453:Prostaglandins / Q000302:isolation & purification*; D011458:Prostaglandins E / Q000494:pharmacology; D011460:Prostaglandins F / Q000494:pharmacology; D014590:Uterine Contraction / Q000187:drug effects*
D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; D011464:Epoprostenol