A rhelogical separator for very large DNA molecules.
We present a rheological separation method for DNA molecules in which their deformability is used to advantage. This is the "radial migration method"; here we present experimental verification of the principle, theory having been reported elsewhere. The main conclusions are: (1) the theory is reasonably good; (2) radial migration is highly sensitive to the molecular weight, as predicted, and (3) intact T2 DNA (1.25 X 108 daltons) can be made to migrate about three centimeters in less than three hours.
D000818:Animals; D002417:Cattle; D004247:DNA / Q000302:isolation & purification*; D004279:DNA, Viral / Q000302:isolation & purification*; D004926:Escherichia coli / Q000032:analysis; D008722:Methods; D008970:Molecular Weight; D013604:T-Phages / Q000032:analysis; D013950:Thymus Gland / Q000032:analysis
D004279:DNA, Viral; D004247:DNA