Influence of oil and Tween concentrations on enhanced endotoxin lethality in mice pretreated with emulsified trehalose-6,6'-dimycolate (cord factor).
Susceptibility to the lethal toxicity of endotoxin in mice pretreated with emulsified trehalose-6,6'-dimycolate was enhanced by (i) increasing the oil concentration while keeping the Tween concentration constant; and (ii) decreasing the Tween concentration, while keeping the oil concentration constant.
D000818:Animals; D001500:BCG Vaccine; D003311:Cord Factors / Q000008:administration & dosage / Q000276:immunology / Q000494:pharmacology*; D004655:Emulsions; D004731:Endotoxins / Q000633:toxicity*; D006017:Glycolipids / Q000494:pharmacology*; D051379:Mice; D009163:Mycobacterium bovis / Q000276:immunology; D009821:Oils / Q000494:pharmacology*; D011092:Polyethylene Glycols / Q000494:pharmacology*; D011136:Polysorbates / Q000494:pharmacology*
D001500:BCG Vaccine; D003311:Cord Factors; D004655:Emulsions; D004731:Endotoxins; D006017:Glycolipids; D009821:Oils; D011136:Polysorbates; D011092:Polyethylene Glycols