Inhibition of the growth of Lewis lung carcinoma in syngeneic mice by Salmonella antigens.
Administration of a protein antigen preparation from Salmonella enteritidis 11RX at the site of challenge with Lewis lung carcinoma inhibited tumour development in mice previously immunised with live bacteria, but not control mice. The kinetics of tumour growth indicated that the inhibition of tumour development was due to a reduction of the initial tumour inoculum rather than the development of specific anti-tumour immunity.
D000818:Animals; D000942:Antigens, Bacterial / Q000008:administration & dosage*; D002277:Carcinoma / Q000276:immunology / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009362:Neoplasm Metastasis; D009374:Neoplasms, Experimental / Q000276:immunology / Q000517:prevention & control*; D012477:Salmonella enteritidis / Q000276:immunology*
D000942:Antigens, Bacterial