Creutzfeldt-Jakob disease--alteration in ganglioside sphingosine in the brain of a patient.
Gangliosides isolated from the brain of patients with Creutzfelt-Jakob (C-J) disease were analyzed. The ganglioside current was abnormally low, and the percentage distributions of individual gangliosides and the long-chain base compositions were abnormal. The C20-sphingosine contents of all the ganglioside fractions were low. Abnormalities in ganglioside long-chain bases in adult human brain have been reported previously only in patients with inherited metabolic disorders. These abnormalities in C-J disease seem to be closely related to the cause of the disease.
D001923:Brain Chemistry; D055598:Chemical Phenomena; D002621:Chemistry; D007562:Creutzfeldt-Jakob Syndrome / Q000378:metabolism*; D005260:Female; D005732:Gangliosides / Q000032:analysis*; D006801:Humans; D008875:Middle Aged; D013110:Sphingosine / Q000032:analysis
D005732:Gangliosides; D013110:Sphingosine