Early intermediates in the biosynthesis of ansamycins. II. Isolation and identification of proansamycin B-M1 and protorifamycin i-M1.
Proansamycin B-M1 and protorifamycin I-M1 were isolated as minor compounds from fermentations of the protorifamycin I producing strain Nocardia mediterranei F 1/24, identified by means of chemical and spectroscopic methods and shown to be degradation products of the hypothetical proansamycin B postulated in part I of this series of papers and of protorifamycin I, respectively.
D000900:Anti-Bacterial Agents / Q000032:analysis / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001711:Biotransformation; D002176:Candida albicans / Q000187:drug effects; D005285:Fermentation; D047029:Lactams, Macrocyclic; D009615:Nocardia / Q000378:metabolism
D000900:Anti-Bacterial Agents; D047029:Lactams, Macrocyclic