Transfer of bromocriptine across the blood-brain barrier in man.
The transfer of 14C-bromocriptine across the blood-brain barrier was studied in 10 patients using the double indicator single injection method. The extraction (E) of bromocriptine was 8 % (quartiles: 6 and 14 %). Based on the results the cerebral uptake velocity of bromocriptine was calculated assuming constant arterial drug concentration. Its T 1/2 was found to be 12--24 minutes, depending on the tissue-blood partition coefficient.
D000328:Adult; D000368:Aged; D001812:Blood-Brain Barrier; D001921:Brain / Q000378:metabolism; D001927:Brain Diseases / Q000188:drug therapy*; D001971:Bromocriptine / Q000097:blood / Q000378:metabolism* / Q000627:therapeutic use; D002250:Carbon Radioisotopes; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011865:Radioisotope Dilution Technique; D013997:Time Factors
D002250:Carbon Radioisotopes; D001971:Bromocriptine