title: Lymphocyte subpopulations in man: relationship between four subpopulations identified by membrane markers.
abstract: The interrelationship between four subpopulations of human lymphocytes was studied in eight normal persons. Double marking and fractionation experiments established that lymphocytes with receptors for AET-treated sheep erythrocytes constitute a population complementary to cells that carry surface membrane immunoglobulins as they are identified by polyvalent rabbit anti-human immunoglobulin; the latter includes nearly all cells with complement receptors. Two functionally different receptors for antigen-bound IgG are identified by their binding avidity for rabbit-antibody-sensitized ox erythrocytes, defining populations of lymphocytes with high-avidity and low-avidity receptors, indicating two valuable differentiation markers.
mesh_terms: D000915:Antibody Affinity; D001666:Binding Sites, Antibody; D005591:Chemical Fractionation; D003165:Complement System Proteins; D006801:Humans; D007141:Immunoglobulin Fc Fragments; D007158:Immunologic Techniques; D008214:Lymphocytes / Q000276:immunology*; D010587:Phagocytosis; D011947:Receptors, Antigen, B-Cell; D012397:Rosette Formation
chemical_list: D007141:Immunoglobulin Fc Fragments; D011947:Receptors, Antigen, B-Cell; D003165:Complement System Proteins