Mutagenicity of pyrrolizidine alkaloids in the Salmonella/mammalian-microsome test.
The mutagenicities of 7 pyrrolizidine alkaloids to Salmonella typhimurium TA100 were demonstrated by a modified Ames's method. The pyrrolizidine alkaloids found to be mutagenic were clivorine, fukinotoxin, heliotrine, lasiocarpine, ligularidine, LX201 and senkirkine. Pre-incubation of these alkaloids with S9 mix and bacteria in a liquid medium was essential for demonstration of their mutagenicities.
D000818:Animals; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D008099:Liver / Q000378:metabolism; D008862:Microsomes, Liver / Q000378:metabolism*; D009154:Mutation / Q000187:drug effects*; D011759:Pyrrolidines / Q000378:metabolism; D011763:Pyrrolizidine Alkaloids / Q000494:pharmacology*; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects*; D013329:Structure-Activity Relationship
D011759:Pyrrolidines; D011763:Pyrrolizidine Alkaloids