Failure of trimethoprim/sulfamethoxazole in invasive Nocardia asteroides infection.
A case of pulmonary nocardiosis occurred with progressive involvement of the pleura, pericardium, mediastinum, and sternum. Surgical resection and drainage procedures followed by administration of the drug combination, trimethoprim/sulfamethoxazole, over a six-month period led to clinical recovery. Discontinuation of drug therapy, however, was followed by relapse and further invasion by the same organism. A literature survey of Nocardia asteroides infections treated with trimethoprim/sulfamethoxazole disclosed that posttreatment follow-up is often too brief or unknown, making the ultimate success of therapy uncertain.
D000284:Administration, Oral; D000328:Adult; D004322:Drainage; D004338:Drug Combinations; D006801:Humans; D008171:Lung Diseases / Q000188:drug therapy* / Q000601:surgery; D008297:Male; D009617:Nocardia Infections / Q000188:drug therapy* / Q000601:surgery; D009616:Nocardia asteroides / Q000302:isolation & purification; D012008:Recurrence; D013420:Sulfamethoxazole / Q000008:administration & dosage / Q000627:therapeutic use*; D014295:Trimethoprim / Q000008:administration & dosage / Q000627:therapeutic use*
D004338:Drug Combinations; D014295:Trimethoprim; D013420:Sulfamethoxazole