title: Tetracyclines and host defence mechanisms. Doxycyclinepolymethaphosphate sodium complex (DMSC) compared to doxycycline with regard to influence on some host defence mechanisms.
abstract: A new doxycycline preparation, doxycycline polymethaphosphate sodium complex (DMSC), was compared to doxycycline in a cross-over study on six volunteers. The serum levels attained were of the same magnitude, but DMSC was shown to influence the serum bactericidal effect to a lesser degree. In vitro investigations of the influence on chemotaxis showed that DMSC even in high concentrations did not interfere with the spontaneous or induced migration to the same extent as doxycycline.
mesh_terms: D001770:Blood Bactericidal Activity / Q000187:drug effects*; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D004318:Doxycycline / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology*; D004926:Escherichia coli / Q000276:immunology; D005260:Female; D006801:Humans; D008297:Male; D009504:Neutrophils / Q000187:drug effects
chemical_list: D004318:Doxycycline