Inhibition of transpeptidase activity in Escherichia coli by thienamycin.
Thienamycin was shown to be a more potent inhibitor than ampicillin of the enzyme peptidoglycan transpeptidase from Escherichia coli.
D000217:Acyltransferases / Q000037:antagonists & inhibitors*; D000667:Ampicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects* / Q000201:enzymology; D007769:Lactams / Q000494:pharmacology; D010457:Peptidoglycan; D010458:Peptidyl Transferases / Q000037:antagonists & inhibitors*; D013845:Thienamycins
D000900:Anti-Bacterial Agents; D007769:Lactams; D010457:Peptidoglycan; D013845:Thienamycins; D000667:Ampicillin; D000217:Acyltransferases; D010458:Peptidyl Transferases; C015537:thienamycin