Mutagenicity of nitrosamines formed from nitrosation of spermidine.
5 nitrosamines formed from the nitrosation of spermidine were investigated for mutagenicity using various strains of Salmonella typhimurium in the presence and absence of S9 mix. Using the plate incorporation method, 3-butenyl-(2-propenyl)-N-nitrosamine, 3-hydroxybutyl (2-hydroxypropyl)-N-nitrosamine, 4-hyroxybutyl-(2-hydroxypropyl)-N-nitrosamine, 4 hydroxybutyl-(3-hydroxypropyl)-N-nitrosamine, and in the liquid test 3-hydroxybutyl-(3-hydroxypropyl)-N-nitrosamine were mutagenic in the absence of S9 mix.
D004305:Dose-Response Relationship, Drug; D009154:Mutation / Q000187:drug effects*; D009602:Nitrosamines / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000187:drug effects*; D013095:Spermidine / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D009602:Nitrosamines; D013095:Spermidine