Comparative blanching activities of locally manufactured proprietary fluocinolone acetonide topical preparations.
The blanching activities and hence the bio-availabilities of the cream and ointment formulations of Synalar and Cortoderm (fluocinolone acetonide 0,025%) were evaluated using an occluded and unoccluded blanching assay. Statistical analysis showed significant differences between similar formulations of fluocinolone acetonide.
D000277:Adjuvants, Pharmaceutic / Q000494:pharmacology; D000287:Administration, Topical; D001682:Biological Availability; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D005446:Fluocinolone Acetonide / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans; D008297:Male; D012880:Skin Pigmentation / Q000187:drug effects*
D000277:Adjuvants, Pharmaceutic; D005446:Fluocinolone Acetonide