The inhibitory effect of PGI2 (prostacyclin) on white platelet arterial thrombus formation.
Prostaglandins play an important role in the platelet-vessel wall interactions. Superfusion with PGI2 of arterial segments prepared in an in vivo model for thrombus induction resulted in a very marked dose-effect-related decrease of white arterial thrombus formation.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D001792:Blood Platelets / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D011464:Epoprostenol / Q000494:pharmacology*; D011453:Prostaglandins / Q000494:pharmacology*; D051381:Rats; D013927:Thrombosis / Q000139:chemically induced*
D011453:Prostaglandins; D000244:Adenosine Diphosphate; D011464:Epoprostenol