title: Mutational studies with diquat and paraquat in vitro.
abstract: Diquat and paraquat were assayed in the following tests. (1) Ames test in Salmonella typhimurium (strains TA1535, TA1537, TA1538, TA98 and TA100) with and without rat-liver microsomal fractions. (2) Resistance to 8-azaguanine in Salmonella typhimurium (strain hisG46, TA92 and TA1535. (3) Repair test in Salmonella typhimurium (strains TA1538 and TA1978). (4) Gene mutations in Aspergillus nidulans: 8-AG resistance and methionine suppression (meth A1 locus). (5) Lethal recessive damage in Aspergillus nidulans. (6) Unscheduled DNA synthesis (UDS) in human epithelial-like cells (EUE). Diquat and paraquat were positive in S. typhimurium (in the repair test and the 8-AG resistance system), in A. nidulans (for gene mutations and lethal recessive damage induction) and in EUE cells (UDS induction).
mesh_terms: D000818:Animals; D001233:Aspergillus nidulans / Q000187:drug effects*; D001375:Azaguanine; D002460:Cell Line; D004260:DNA Repair; D004178:Diquat / Q000378:metabolism / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D004848:Epithelium; D006801:Humans; D008862:Microsomes, Liver / Q000378:metabolism*; D009132:Muscles; D009154:Mutation / Q000187:drug effects*; D010269:Paraquat / Q000378:metabolism / Q000494:pharmacology*; D011726:Pyridinium Compounds / Q000494:pharmacology*; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects*; D012867:Skin
chemical_list: D011726:Pyridinium Compounds; D004178:Diquat; D010269:Paraquat; D001375:Azaguanine