Penicillin levels in blood and CSF achieved by treatment of syphilis.
Treponemicidal levels of penicillin in the CSF were not obtained following intramuscular (IM) injections of 600,000 IU of penicillin G procaine along with 2% aluminum monostearate (PAM). Treponemicidal levels of penicillin in the CSF were achieved in 31 patients by probenecid, 500 mg/6 hr by mouth, with penicillin G, 500,000 IU by IM injection, and by probenecid every six hours by mouth and IM injections of penicillin G procaine once a day in two of three patients following injections of 600,000 IU, in four of five following 1.2 million IU, and in three (now all nine) following 2.4 million IU.
D000284:Administration, Oral; D006801:Humans; D007273:Injections, Intramuscular; D010400:Penicillin G / Q000097:blood / Q000134:cerebrospinal fluid; D010402:Penicillin G Procaine / Q000097:blood / Q000134:cerebrospinal fluid / Q000494:pharmacology; D010403:Penicillin Resistance; D010406:Penicillins / Q000097:blood* / Q000134:cerebrospinal fluid*; D011339:Probenecid / Q000097:blood / Q000134:cerebrospinal fluid; D013587:Syphilis / Q000188:drug therapy*; D013590:Syphilis, Congenital / Q000188:drug therapy; D013592:Syphilis, Latent / Q000188:drug therapy; D014210:Treponema pallidum / Q000187:drug effects
D010406:Penicillins; D010402:Penicillin G Procaine; D011339:Probenecid; D010400:Penicillin G