title: [Manifestation of a malignant lymphoma of high grade malignancy in the terminal stage of mycosis fungoides. Enzyme-cytochemical and immunocytological investigations (author's transl)].
abstract: Report on a patient with mycosis fungoides, in whom after a long course the disease developed rapidly into a malignant lymphoma of high grade malignancy. The diagnosis was confirmed by cytomorphological and enzyme-cytochemical methods (demonstration of hydrolytic enzymes in cryostat sections, cutaneous smears and cell suspensions extracted from skin lesions), as well as by immunocytological methods (differentiation of lymphocyte sub-populations). In the tumour stage of mycosis fungoides, a polymorphous infiltrate composed of lymphocytoid and monocytoid cells prevailed, while a proliferation of lymphoblastic cells was present in the terminal stage of the disease. These cells showed no longer the properties of mature lymphocytes and differed also in their enzyme-cytochemical pattern.
mesh_terms: D006651:Histocytochemistry; D006801:Humans; D007158:Immunologic Techniques; D008223:Lymphoma / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000150:complications* / Q000473:pathology; D012867:Skin / Q000201:enzymology / Q000473:pathology*; D012878:Skin Neoplasms / Q000150:complications / Q000209:etiology* / Q000276:immunology / Q000473:pathology
vernacular_title: Manifestation eines malignen Lymphoms von hohem Malignitätsgrad im Spätstadium der Mycosis fungoides. Enzymzytochemische und immunzytologische Untersuchungen.