Interferon induction in mice by uniform salt forms of Shigella sonnei lipopolysaccharide and its components.
Interferon-inducing capacity of uniform salts of Shigella sonnei lipopolysaccharide (LPS), its polysaccharide component and lipid A were compared. Low-molecular-weight triethylamine and ethanolamine salt forms of the lipopolysaccharide were most active in interferon production. It was confirmed that lipid part of LPS is responsible for interferon-inducing activity.
D000818:Animals; D005227:Fatty Acids / Q000276:immunology; D005615:Freezing; D006358:Hot Temperature; D007369:Interferon Inducers; D007372:Interferons / Q000096:biosynthesis*; D008050:Lipid A / Q000276:immunology; D008070:Lipopolysaccharides / Q000276:immunology*; D051379:Mice; D011135:Polysaccharides, Bacterial / Q000276:immunology; D012492:Salts; D012764:Shigella sonnei / Q000276:immunology*; D013329:Structure-Activity Relationship
D005227:Fatty Acids; D007369:Interferon Inducers; D008050:Lipid A; D008070:Lipopolysaccharides; D011135:Polysaccharides, Bacterial; D012492:Salts; D007372:Interferons