[Factors that control the differentiation of stem cells. I. The change in direction of hematopoietic stem cell differentiation under the effect of differentiating T-lymphocytes].
A mixed transplantation of bone marrow cells, and lymph nodes or thymic cells of mice CBA strain into lethally irradiated hybrid recipients (CBAXC57B1)F1 is accompanied with changes in the differentiation pattern from a mainly erythroid to a mainly granuloid way. Thymectomy of either donor of bone marrow cells or recipients, or both, destroys the stem cell differentiation in the direction of granulopoieseis. Intact syngeneic lymphocytes normalize differentiation of the stem cells, but in the presence of tissue antigens these provide for the stem cell differentiation mainly in the direction of granulopoiesis. The differentiation of stem haemopoietic cells is accomplished under the thymic and lymphocyte control. T-differentiating lymphocytes (Td) are the lymphocytes controlling the stem cell differentiation.
D000818:Animals; D001402:B-Lymphocytes / Q000637:transplantation; D001853:Bone Marrow / Q000528:radiation effects; D016026:Bone Marrow Transplantation; D002454:Cell Differentiation / Q000528:radiation effects; D005720:Gamma Rays; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006649:Histocompatibility Antigens / Q000276:immunology; D008198:Lymph Nodes / Q000528:radiation effects; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013601:T-Lymphocytes / Q000166:cytology* / Q000637:transplantation; D013934:Thymectomy; D013950:Thymus Gland / Q000528:radiation effects; D014185:Transplantation, Isogeneic
D006649:Histocompatibility Antigens
Faktory, kontroliruiushchie differentsirovku stvolovykh kletok. I. Izmenenie napravlenie differentsirovki stvolovykh krovetvornykh kletok pod vliianiem differentsiruiushchikh T-limfotsitov.