[Contribution to the clinicopharmacological fundamentals of the orthostasis syndrome (author's transl)].
We have carried out therapeutic trials in 20 orthostatic patients (ages ranging between 20 and 35 years) with unequivocal signs of a static-labile circulatory disturbance. The test programme was used three days per week over a three-week period (medication of Amphodyn-retard). The test programme consisted of measurements of the systolic and diastolic blood pressure, the pulse pressure and the pulse rate at one-minute intervals during a resting, loading (standing) and recovery phase, each covering seven minutes; further measurements of the flicker fusion threshold (FFT) in each case in the 3rd and 4th minute in each of the three study phases. Compensation of disturbances of orthostatic regulation was observed as a result of the treatment: Unchanged systolic and diastolic blood pressure during loading, narrowing of the pulse pressure did not occur, and the pulse rate increased only slightly. There was an increase in the flicker fusion threshold as an expression of the stabilization which was slightly significant. The associated subjective symptoms improved.
D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D003692:Delayed-Action Preparations; D004311:Double-Blind Method; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007024:Hypotension, Orthostatic / Q000188:drug therapy*; D008297:Male; D011187:Posture; D011674:Pulse / Q000187:drug effects; D013997:Time Factors
D000959:Antihypertensive Agents; D003692:Delayed-Action Preparations
Beitrag zu den klinisch-pharmakologischen Grundlangen des Orthostasessyndroms.