Mitochondrial mutagenesis in Saccharomyces cerevisiae. III. Nitrous acid.
Nitrous acid (NA) induced mutations efficiently in mitDNA, conferring resistance to erythromycin and weakly induces mit- mutations. In some strains of yeast it also enhanced rho- mutations. The frequencies of nuclear and mitochondrial mutations induced with NA are compared.
D004271:DNA, Fungal / Q000235:genetics*; D004272:DNA, Mitochondrial / Q000235:genetics*; D004352:Drug Resistance, Microbial; D004917:Erythromycin / Q000494:pharmacology; D005787:Gene Frequency; D009153:Mutagens; D009154:Mutation; D009573:Nitrites / Q000494:pharmacology*; D009608:Nitrous Acid / Q000494:pharmacology*; D010641:Phenotype; D012441:Saccharomyces cerevisiae / Q000235:genetics*
D004271:DNA, Fungal; D004272:DNA, Mitochondrial; D009153:Mutagens; D009573:Nitrites; D004917:Erythromycin; D009608:Nitrous Acid