ABH and Lewis antigens on lymphocytes: screening of pregnant women's sera with the B-cell cytotoxicity test.
Five phenotypes related to the ABH-Lewis substances were defined by the B-cell lymphocytotoxic test. These five antigens are built up in a stepwise fashion by the action of the glycosyl transferases specified by the Le, H, and the A, B genes onto the same ABO percursor molecules. The comparison of their chemical structures with the cluster analysis obtained by cytotoxicity suggests that antibodies reacting with large antigenic structures (pentasaccharides) have a more restricted specificity than antibodies reacting only with smaller antigenic determinants (trisaccharides).
D000017:ABO Blood-Group System / Q000276:immunology*; D000961:Antilymphocyte Serum / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D005189:False Positive Reactions; D005260:Female; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D016030:Kidney Transplantation; D007983:Lewis Blood Group Antigens / Q000276:immunology*; D009844:Oligosaccharides / Q000276:immunology; D010641:Phenotype; D011247:Pregnancy; D013601:T-Lymphocytes / Q000276:immunology; D014312:Trisaccharides / Q000276:immunology
D000017:ABO Blood-Group System; D000961:Antilymphocyte Serum; D006680:HLA Antigens; D007983:Lewis Blood Group Antigens; D009844:Oligosaccharides; D014312:Trisaccharides