Therapeutic trial of the combination in an eye lotion of adrenaline (0.5 or 1%) and guanethidine (3 or 5%) in cases of open-angle glaucoma.
Treatment of open-angle glaucoma has always been problematical, either because of the lack of efficacy, the inconvenience of multiple medication (handled by the patient with difficulty), or due to the high incidence of side effects. This study showed that an association of adrenaline and guanethidine in drop form, used in cases of open-angle glaucoma, achieved a rapid and lasting stabilisation of intraocular pressure. The main advantage of this form is the combination of two active ingredients for instillation twice daily. In addition, the pH and the nature and concentration of the ingredients are such that side effects, if they occur, do so at the beginning of treatment and are of short duration.
D002986:Clinical Trials as Topic; D004338:Drug Combinations; D004341:Drug Evaluation; D004837:Epinephrine / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D005901:Glaucoma / Q000188:drug therapy*; D006145:Guanethidine / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D009883:Ophthalmic Solutions; D014792:Visual Acuity / Q000187:drug effects
D004338:Drug Combinations; D009883:Ophthalmic Solutions; D004837:Epinephrine; D006145:Guanethidine