[Characterization and comparison of the clinical and morphological changes in adriamycin cardiomyopathy].
Through comparative clinical and pathological findings a dose-response relationship for the cardiotoxic effect of adriamycine could be proved. A myocardial damage without clinical relation could already be seen at a dose of 125 mg/m2 body surface by patho-histological examination. Therefore, all patients being treated with adriamycine should be regularly and carefully cardiologically supervised in order to avoid an irreversible cardiomyopathy.
D000328:Adult; D001344:Autopsy; D009202:Cardiomyopathies / Q000139:chemically induced* / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology; D013997:Time Factors
D004317:Doxorubicin
Charakterisierung und Vergleich der klinischen und morphologischen Veränderungen bei der Adriamycin-Kardiomyopathie.