Monitoring of rejection.
Rejection in non-identical pairs is both antibody- and cell-mediated. Measurements of CDC and LMC specific for the donor can be useful clinical tools in confirming rejection, detecting periods of likely rejection, and helping to predict responses to therapy. In particular, the LMC assay appears to have excellent temporal correlations with graft status. Rejection in the HLA-identical sibling transplant is directed against a non-MHC antigen, is cell-mediated, and can be typed for using CTL.
D000906:Antibodies; D000920:Antibody-Dependent Cell Cytotoxicity; D003165:Complement System Proteins / Q000502:physiology; D003601:Cytotoxicity Tests, Immunologic; D004727:Endothelium / Q000276:immunology; D006084:Graft Rejection; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D007111:Immunity, Cellular; D007141:Immunoglobulin Fc Fragments; D007957:Leukocyte Adherence Inhibition Test; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology; D008263:Macrophage Migration-Inhibitory Factors / Q000032:analysis; D008934:Mitogens; D012397:Rosette Formation; D014181:Transplantation Immunology
D000906:Antibodies; D006680:HLA Antigens; D007141:Immunoglobulin Fc Fragments; D008263:Macrophage Migration-Inhibitory Factors; D008934:Mitogens; D003165:Complement System Proteins