title: The effect of pantothenate on sulfate metabolism and sulfur isotope fractionation by Saccharomyces cerevisiae.
abstract: Growth of Saccharomyces cerevisiae in minimal salts-glucose-SO4(2-) medium with varying concentrations of pantothenate (0-1000 microgram/L) produced changes in the cellular lipid content and in the ratio of saturated to unsaturated fatty acids. Substantial differences in SO4(2-) diffusion were also observed with changes in pantothenate concentration. During sulfate reduction, the delta 34S value of the evolved sulfide varied with the pantothenate concentration ranging from -31% in the absence of pantothenate to 0% at 400-1000 microgram/L pantothenate. The isotope selectivity is related to the effect of pantothenate concentration on cellular metabolism.
mesh_terms: D005227:Fatty Acids / Q000096:biosynthesis; D005231:Fatty Acids, Unsaturated / Q000096:biosynthesis; D008055:Lipids / Q000096:biosynthesis; D008670:Metals / Q000494:pharmacology; D010205:Pantothenic Acid / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000378:metabolism; D013431:Sulfates / Q000378:metabolism*; D013440:Sulfides / Q000378:metabolism; D013460:Sulfur Isotopes
chemical_list: D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D008055:Lipids; D008670:Metals; D013431:Sulfates; D013440:Sulfides; D013460:Sulfur Isotopes; D010205:Pantothenic Acid