Adriamycin in localized and metastatic uterine sarcomas.
Seventeen women with metastatic uterine sarcomas were treated with Adriamycin chemotherapy. Only one (6%) had an objective response. In addition, 12 patients with early uterine sarcomas were randomized to Adriamycin versus no adjuvant chemotherapy in order to evaluate the effect of Adriamycin in reducing the incidence of subsequent distant recurrences. Of those women receiving Adriamycin, two developed distant metastasis and two developed life-threatening congestive heart failure. Also, two of the six women who did not receive Adriamycin developed distant metastasis. Therefore, continuation of the randomized trial was considered unjustified.
D002986:Clinical Trials as Topic; D004317:Doxorubicin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D011446:Prospective Studies; D012509:Sarcoma / Q000188:drug therapy* / Q000556:secondary; D014594:Uterine Neoplasms / Q000188:drug therapy* / Q000556:secondary
D004317:Doxorubicin