Membranous glomerulonephritis in congenital syphilis.
The glomerulonephritis of congenital syphilis is thought to be immune-complex mediated. We describe a case of C. S. in whom the only manifestation was a glomerulonephritis. Immunopathogenic studies allowed the identification of treponemal antigen in glomeruli. The elution of immunoglobulins from renal tissue showed that glomerular deposits contained antitreponemal antibodies. Cryoglobulins with antitreponemal activity were also isolated from the patient's serum.
D000907:Antibodies, Bacterial / Q000276:immunology; D000936:Antigen-Antibody Complex; D000942:Antigens, Bacterial / Q000276:immunology; D003165:Complement System Proteins / Q000276:immunology; D003450:Cryoglobulins / Q000276:immunology; D005260:Female; D005921:Glomerulonephritis / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007223:Infant; D007668:Kidney / Q000276:immunology / Q000473:pathology; D013590:Syphilis, Congenital / Q000276:immunology* / Q000473:pathology; D014210:Treponema pallidum / Q000276:immunology
D000907:Antibodies, Bacterial; D000936:Antigen-Antibody Complex; D000942:Antigens, Bacterial; D003450:Cryoglobulins; D003165:Complement System Proteins