title: [Clinical effectiveness of carbenicillin in suppurative inflammatory processes of varying localization].
abstract: The study on sensitivity of clinical strains of the causative agents of purulent infections to carbenicillin showed that 34.6% of the staphylococcal strains, 48.1% of the E. coli strains and 40.3% of the Proteus strains were sensitive to the antibiotic. The strains of Ps. aeruginosa were characterized by moderate sensitivity to carbenicillin. The MTC for most of the isolates ranged within 25-128 microgram/ml. High therapeutic efficacy of carbenicillin in treatment of cases with purulent inflammatory processes of various localization was shown. Positive results were obtained in 82.5% of the adults and 76.2% of the premature infants treated with carbenicillin. A satisfactory therapeutic effect was observed in the cases with sepsis, diffuse purulent peritonitis and abscessing pneumonia treated with carbenicillin in combination with gentamicin.
mesh_terms: D000328:Adult; D000667:Ampicillin / Q000627:therapeutic use; D002228:Carbenicillin / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005839:Gentamicins / Q000627:therapeutic use; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000188:drug therapy; D007249:Inflammation / Q000188:drug therapy*; D008826:Microbial Sensitivity Tests; D013492:Suppuration / Q000188:drug therapy*
chemical_list: D005839:Gentamicins; D000667:Ampicillin; D002228:Carbenicillin
vernacular_title: Klinicheskaia éffektivnost' karbenitsillina pri gnoĭno-vospalitel'-nykh protsessakh razlichnoĭ lokalizatsii.