[Long-term, complete remission in non-Hodgkin's lymphoma following high-dosage combination therapy with or without autologous bone marrow transplantation].
22 patients with malignant non-Hodgkin lymphoma resistant to conventional chemotherapy were treated with high-dose combination chemotherapy followed in the first 12 patients by infusion of their cryopreserved autologous bone marrow. The next 10 patients received chemotherapy alone. Four patients died shortly after chemotherapy. Four patients remain in unmaintained remission 40, 30, 20 and 8 months after treatment. Patients receiving cryopreserved marrow recovered leukocyte, granulocyte and platelet function significantly faster and had significantly fewer febrile days than did controls. These findings demonstrate that high dose combination chemotherapy may benefit some patients unresponsive to conventional chemotherapy, and that cryopreserved bone marrow can speed hematopoetic recovery and be of clinical benefit to the patient.
D000970:Antineoplastic Agents / Q000008:administration & dosage*; D016026:Bone Marrow Transplantation; D004359:Drug Therapy, Combination / Q000379:methods; D006801:Humans; D008223:Lymphoma / Q000188:drug therapy* / Q000601:surgery; D014182:Transplantation, Autologous
D000970:Antineoplastic Agents
Langdauernde, vollständige Remission bei Non-Hodgkin-Lymphomen nach hochdosierter Kombinations-Chemotherapie mit oder ohne autologe Knochenmarktransplantation.