Mutagenic effects of cadmium on mammalian oocyte chromosomes.
When female golden hamsters were treated with cadmium chloride at the oogenesis stages of diakinesis/metaphase I to metaphase II, oocytes with the chromosomal complements of hyperhaploidy and diploidy, as well as oocytes at the anaphase-I stage, were observed. Oocytes of this species were especially sensitive to cadmium. Chromosome analysis of metaphase-II oocytes seems to be a useful method for the screening of mutagenicity of environmental contaminants in mammalian germ cells in vivo.
D000818:Animals; D002104:Cadmium / Q000494:pharmacology*; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects; D006224:Cricetinae; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D005260:Female; D005821:Genetic Techniques; D009153:Mutagens; D009865:Oocytes / Q000648:ultrastructure
D009153:Mutagens; D002104:Cadmium