The effects of reserpine on microcirculatory flow in rat flaps.
A model flap was developed in the rat which allowed us to quantitate microcirculatory blood flow within a flap, and to correlate the flow with the length of flap eventually surviving. A critical flow of 0.02 and 0.03 ml/min/gm (measured during the first 24 hours after flap elevation by radioactive microspheres) appears to be necessary for tissue survival. Reserpine, in a dose of 5 mg/kg, did not increase blood flow in the flap or the length of flap surviving in this model.
D000818:Animals; D002302:Cardiac Output / Q000187:drug effects; D005260:Female; D006085:Graft Survival / Q000187:drug effects*; D008833:Microcirculation / Q000187:drug effects; D008863:Microspheres; D051381:Rats; D012039:Regional Blood Flow / Q000187:drug effects; D012110:Reserpine / Q000494:pharmacology*; D012867:Skin / Q000098:blood supply / Q000473:pathology; D016038:Skin Transplantation; D014182:Transplantation, Autologous
D012110:Reserpine