title: [Soluble mediators as a means of communication between lymphozytes in immune reactions (author's transl)].
abstract: Soluble mediators play an important role in the positive and negative regulation of immune reactions. This has been particularly well documented for T-B-cooperation in the humoral immune response to T-dependent antigens. T-helper cells produce a T-cell replacing Factor (TRF) upon mitogenic or antigenic stimulation. It provides the signal to antigen triggered B-cells to begin with active antibody synthesis and secretion and thus it is a positively regulating mediator. Additional functional and some structural characteristics of TRF are described. Antigen specific and non-specific suppressor factors seem to be involved in the negative regulation of immune responses. Thus, the communication between cells of the immune system is largely conducted via soluble signal substances.
mesh_terms: D000917:Antibody Formation; D000941:Antigens; D001402:B-Lymphocytes / Q000276:immunology*; D002454:Cell Differentiation; D004912:Erythrocytes / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D007075:Immunoglobulin M; D007156:Immunologic Memory; D008213:Lymphocyte Activation; D008222:Lymphokines / Q000502:physiology*; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000941:Antigens; D007075:Immunoglobulin M; D008222:Lymphokines
vernacular_title: Mediatorstoffe als Kommunikationsmittel von Lymphocyten bei der Immunreaktion.