title: Unstable transpositions of his4 in yeast.
abstract: Unstable transpositions in yeast have been selected in which the his4C gene from chromosome III is inserted into chromosome XII. This event is associated with the generation of a recessive lethal mutation, resulting from the integration of his4C into an essential gene. Strains with these transpositions are viable as diploids or aneuploids for chromosome XII. The event that generates the transpositions does not lead reciprocally to a deletion on chromosome III, implying that synthesis of a new copy of his4C and subsequent transposition may have occurred. The his4C transpositions are unstable and give rise to C- segregants at a high frequency, as a result of either precise excision of the his4C gene (restoring function of the gene into which insertion had occurred) or chromosome loss.
mesh_terms: D000429:Alcohol Oxidoreductases / Q000235:genetics; D000782:Aneuploidy; D002874:Chromosome Mapping; D004251:DNA Transposable Elements; D005796:Genes; D005804:Genes, Lethal; D008040:Genetic Linkage; D006639:Histidine / Q000235:genetics*; D006641:Histidinol; D012441:Saccharomyces cerevisiae / Q000235:genetics*
chemical_list: D004251:DNA Transposable Elements; D006639:Histidine; D006641:Histidinol; D000429:Alcohol Oxidoreductases