[Effect of the carbon/nitrogen ratio on the antibiotic activity of prodigiosin].
The antibacterical activity of prodigiosin varies according to the C/N ratio in the cultural media for S. marcescens. In organic media, as nutrient agar, peptone or soytone, the optimal ratio lies between 4 and 5, and higher values are required for "mineral media" where the nitrogen source is essentially an ammonium salt. The separate C source would be probably used as "acetate source" for the synthesis of the terminal alkylpyrrole.
D002244:Carbon / Q000032:analysis; D003470:Culture Media; D009584:Nitrogen / Q000032:analysis; D011353:Prodigiosin / Q000096:biosynthesis / Q000494:pharmacology*; D011758:Pyrroles / Q000378:metabolism; D012706:Serratia marcescens / Q000254:growth & development / Q000378:metabolism; D013329:Structure-Activity Relationship
D003470:Culture Media; D011758:Pyrroles; D002244:Carbon; D009584:Nitrogen; D011353:Prodigiosin
Influenza del rapporto carbonio azoto sull'attività' antibiotica della prodigiosina.