Effect of massive bowel resection on enteroinsular axis.
Pancreatic endocrine function was studied in 13 patients who had undergone massive bowel resection. The patients were divided into two groups: one month after operation (short-term group), and three or more months after operation (long-term group). Oral administration of glucose caused a persistent low insulin secretion in almost all the patients and the glucose tolerance curve showed a diabetic pattern in four. In contrast, the insulin response to intravenously infused arginine was impaired in the short-term group, but was at an approximately normal level in the long-term group. Pancreatic glucagon response to intravenous arginine, however, remained unchanged in both groups. Interruption of the enteroinsular axis as the result of massive bowel resection probably plays a major part in this discrepancy of the behaviour of insulin in the long-term group.
D000328:Adult; D000368:Aged; D001120:Arginine; D001786:Blood Glucose / Q000032:analysis; D005260:Female; D005934:Glucagon / Q000097:blood / Q000378:metabolism; D005951:Glucose Tolerance Test; D006801:Humans; D007082:Ileum / Q000601:surgery*; D007328:Insulin / Q000097:blood / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000378:metabolism*; D007583:Jejunum / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period
D001786:Blood Glucose; D007328:Insulin; D005934:Glucagon; D001120:Arginine