Prevention of immune graft rejection after corneal transplantation.
The effectiveness of fluorometholone was compared to dexamethasone phosphate and prednisolone acetate in preventing the immune corneal graft reaction in rabbits. Clear corneal grafts were obtained. Rejection was induced after skin from the corneal donor animal was grafted subcutaneously in the host animal and the animals were randomized into four treatment groups. Rejection occurred in eight of nine rabbits in the control group; one of eight in the dexamethasone phosphate group; one of eight in the fluorometholone group; and one of ten in the prednisolone acetate group. Histologic examination confirmed the above findings. In this animal study fluorometholone prevented immune graft rejection in a percentage similar to that of prednisolone acetate and dexamethasone phosphate.
D000287:Administration, Topical; D000818:Animals; D016039:Corneal Transplantation; D003907:Dexamethasone / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D005469:Fluorometholone / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D006084:Graft Rejection / Q000187:drug effects*; D007165:Immunosuppression Therapy / Q000379:methods*; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D011817:Rabbits; D016038:Skin Transplantation; D014184:Transplantation, Homologous
D003907:Dexamethasone; D011239:Prednisolone; D005469:Fluorometholone