title: [Antibiotic resistance of Shigella in different regions of the USSR].
abstract: Shigella were most sensitive to polymyxin ceporin, ampicillin, neomycin and furazolidone and resistant to chloramphenicol, tetracycline and streptomycin. Shigella resistant simultaneously to two or three drugs mainly to tetracycline + chloramphenicol, tetracycline + streptomycin and tetracycline + chloramphenicol + streptomycin were most frequent. The frequency of the Shigella strains carrying R-plasmids increased from 28 per cent in 1969--1970 to 72.6 per cent in 1977. The Shigella strains isolated during the dysentery outbreak in 1973--1977 carried the R-factor controlling resistance to tetracycline + chloramphenicol, tetracycline + chloramphenicol + streptomycin, tetracycline + chloramphenicol + streptomycin + neomycin. Interaction between separate biochemical types, colicinogenicity and drug resistance classes was found in the Shigella isolates. The data on the effect of antibiotic (tetracyclines) intensive use in stock-raising defining wide spread of the R-plasmids controlling resistance to these drugs were obtained.
mesh_terms: D000900:Anti-Bacterial Agents / Q000037:antagonists & inhibitors*; D004352:Drug Resistance, Microbial; D011815:R Factors / Q000187:drug effects; D012760:Shigella / Q000187:drug effects*; D012763:Shigella flexneri / Q000187:drug effects; D012764:Shigella sonnei / Q000187:drug effects; D014586:USSR
chemical_list: D000900:Anti-Bacterial Agents
vernacular_title: Antibiotikorezistentnost' shigell na razlichnykh territoriakh strany.