Modification of kidney immunogenicity with standard Concanavalin A and its subfractions.
Pretreatment of kidneys with purified Concanavalin A (25 mg/L) allowed for a significant prolongation of survival after allotransplantation in minimally immunosuppressed mongrel dogs. Kidneys pretreated with standard Concanavalin A, impure fraction or the lipopolysaccharide had no prolongation of survival. In fact, the impure fraction and the lipopolysaccharide showed a diminished transplant kidney survival. These studied confirm the beneficial effect of Concanavalin A when the purified form is utilized in modifying kidney allograft survival.
D000818:Animals; D003208:Concanavalin A / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D006085:Graft Survival; D016030:Kidney Transplantation; D008297:Male; D011309:Preservation, Biological; D013997:Time Factors; D014184:Transplantation, Homologous
D003208:Concanavalin A