Occupational lung cancer and smoking: a review in the light of current theories of carcinogenesis.
This paper considers modern theories of carcinogenesis as they apply to the induction of lung cancer by tobacco smoking and occupational exposure to carcinogens. Some of the known and postulated factors affecting carcinogenesis are discussed, with particular reference to syncarcinogenesis and thresholds. Factors affecting the intensity of smoking exposure are reviewed, and the generally accepted occupational lung carcinogens are listed. Relative risks for the various carcinogens according to smoking status (where known) are presented. The carcinogens are considered individually, and known or postulated interactions with smoking are discussed. It is concluded that the effects of lung carcinogens can be explained on the basis of current theories that support a rational definition of priorities for the prevention of occupational lung cancer.
D001151:Arsenic / Q000009:adverse effects; D001194:Asbestos / Q000009:adverse effects; D001725:Bis(Chloromethyl) Ether / Q000009:adverse effects; D002273:Carcinogens; D003033:Coal Tar / Q000009:adverse effects; D004357:Drug Synergism; D006801:Humans; D008175:Lung Neoplasms / Q000139:chemically induced / Q000209:etiology*; D009381:Neoplasms, Radiation-Induced; D009532:Nickel / Q000009:adverse effects; D009538:Nicotine / Q000009:adverse effects; D009784:Occupational Diseases / Q000209:etiology*; D012306:Risk; D012907:Smoking / Q000150:complications*
D002273:Carcinogens; D001194:Asbestos; D009538:Nicotine; D001725:Bis(Chloromethyl) Ether; D009532:Nickel; D003033:Coal Tar; D001151:Arsenic