title: [Therapy of duodenal ulcer with cimetidine, pirenzipine and placebo: report on a double-blind randomized study].
abstract: A double-blind randomized controlled study with pirenzepine (75 mg/day), cimetidine (1 g/day) and placebo was performed in 50 consecutive out-patients with duodenal ulcer. The patients also received an antacid containing aluminium hydroxide. Pirenzepine, cimetidine and placebo had similar effects on the 4-week healing rate. Dryness of the mouth was more frequent with pirenzepine than with the other two types of treatment. The incidence of other side effects did not differ in the three groups. A tendency towards more rapid disappearance of subjective symptoms in the patients treated with pirenzepine was not statistically significant. In conclusion, pirenzepine and cimetidine were not superior to placebo in the treatment of duodenal ulcer.
mesh_terms: D000328:Adult; D000863:Antacids / Q000627:therapeutic use; D001570:Benzodiazepinones / Q000009:adverse effects / Q000627:therapeutic use*; D002927:Cimetidine / Q000009:adverse effects / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004341:Drug Evaluation; D004381:Duodenal Ulcer / Q000188:drug therapy*; D005260:Female; D006146:Guanidines / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000009:adverse effects / Q000627:therapeutic use*; D010919:Placebos; D013997:Time Factors
chemical_list: D000863:Antacids; D001570:Benzodiazepinones; D006146:Guanidines; D010879:Piperazines; D010919:Placebos; D002927:Cimetidine
vernacular_title: Therapie des Ulcus duodeni mit Cimetidin, Pirenzepin und Placebo: Bericht über eine doppeltblinde, randomisierte Studie.