title: [Comparison of the effects of lofepramin and mianserin in depressed patients in a double blind trial].
abstract: The therapeutic efficacy of two newly developed anti-depressants lofepramine and mianserin was compared in a double-blind clinical trial in 30 depressed inpatients. During the treatment period of 4 weeks the depressive symptoms assessed by the Hamilton Rating Scale for Depression decreased in both groups. In this trial a stronger influence of lofepramine on the factor 'retarded depression' could be demonstrated (p = 0.08). In addition lofepramine showed a significantly better reduction of anxious reactions than mianserin (p less than 0.01). Concerning tolerance, no difference between the two drugs was observed.
mesh_terms: D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D003863:Depression / Q000188:drug therapy*; D003984:Dibenzazepines / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008127:Lofepramine / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008803:Mianserin / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales
chemical_list: D003984:Dibenzazepines; D008803:Mianserin; D008127:Lofepramine
vernacular_title: Wirkungsvergleich von Lofepramin und Mianserin an depressiven Patienten unter Doppelblind-Bedingungen.