title: Antacid therapy and nutritional supplementation in the prevention of Curling's ulcer.
abstract: The incidence of clinically evident Curling's ulcer among 109 potentially salvageable severely burned patients was reviewed. These patients, who had greater than a 40 per cent body surface area burn, received one of these three treatment regimens: antacids hourly until autografting was complete, antacids hourly during the early postburn period followed by nutritional supplementation with Vivonex until autografting was complete or no antacids during the early postburn period but subsequent nutritional supplementation with Vivonex until autografting was complete. Clinically evident Curling's ulcer occurred in three patients. This incidence approximates the lowest reported among severely burned patients treated prophylactically with acid-reducing regimens to minimize clinically evident Curling's ulcer. In addition to its protective effect on Curling's ulcer, Vivonex, when used in combination with a high protein, high caloric diet, meets the caloric needs of the severely burned patient. Probably, Vivonex, which has a pH range of 4.5 to 5.4 protects against clinically evident Curling's ulcer by a dilutional alkalinization of gastric secretion.
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D000863:Antacids / Q000627:therapeutic use*; D002056:Burns / Q000150:complications* / Q000178:diet therapy / Q000188:drug therapy; D002648:Child; D005260:Female; D005526:Food, Formulated; D006471:Gastrointestinal Hemorrhage / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000178:diet therapy / Q000188:drug therapy / Q000517:prevention & control*; D016038:Skin Transplantation; D014182:Transplantation, Autologous
chemical_list: D000863:Antacids