Expression of MHC antigens by mouse thymic dendritic cells.
Thymic epithelial cells express MHC antigens in several different patterns. I-A is present throughout the thymic cortex on dendritic cells. The remainder of the I region and H-2K/D are expressed on dendritic cells apparently only variably in the cortex (at least in some haplotypes). All MHC antigens tested are present in the medulla on epithelial cells; expression on medullary lymphocytes cannot be evaluated. Monoclonal anti-MHC antibodies confirm these results. The significance of these findings to T cell maturation is discussed.
D000818:Animals; D000961:Antilymphocyte Serum / Q000494:pharmacology; D002999:Clone Cells / Q000276:immunology; D003712:Dendrites / Q000276:immunology*; D004848:Epithelium / Q000276:immunology; D005455:Fluorescent Antibody Technique; D006649:Histocompatibility Antigens / Q000276:immunology*; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008979:Moloney murine leukemia virus / Q000276:immunology; D011817:Rabbits; D013950:Thymus Gland / Q000276:immunology*; D014764:Viral Proteins / Q000276:immunology
D000961:Antilymphocyte Serum; D006649:Histocompatibility Antigens; D014764:Viral Proteins