Human Ia-like antigens in non-lymphoid organs.
Human Ia-like antigens in liver and kidney were shown by the immunofluorescence assay to be present mostly in the endothelial-mesenchymal cells of these organs. The parenchymal cells apparently contained no human Ia-like antigens. The antigens in liver and kidney were purified and shown to have the same subunit structure as human Ia-like antigens of cultured B-lymphoid cells. The human Ia-like antigens in non-lymphoid organs, not only in liver and kidney but also in testis, heart, muscle and brain, carried all the xenoantigenic characteristics of human Ia-like antigens expressed on lymphoid cells of B-cell lineage.
D000937:Antigen-Antibody Reactions; D001402:B-Lymphocytes / Q000276:immunology; D004591:Electrophoresis, Polyacrylamide Gel; D005455:Fluorescent Antibody Technique; D006649:Histocompatibility Antigens / Q000302:isolation & purification*; D006801:Humans; D007668:Kidney / Q000276:immunology*; D008099:Liver / Q000276:immunology*; D012157:Mononuclear Phagocyte System / Q000276:immunology
D006649:Histocompatibility Antigens