The release of enterokinase following secretin and cholecystokinin-pancreozymin in man.
The release of enterokinase into human duodenal fluid was studied after intravenous injections of secretin and cholecystokinin-pancreozymin (CCK-PZ). In five control subjects there was a significant release of the enzyme after stimulation with either hormone. A similar release of enterokinase was observed after hormonal stimulation in three patients with total biliary obstruction and in four patients with pancreatic exocrine insufficiency. These results suggest that the hormone-mediated release of enterokinase is independent of bile salts and trypsin in man. This release of enterokinase into duodenal fluid may be physiologically important in protein digestion.
D001647:Bile Acids and Salts / Q000032:analysis; D001660:Biliary Tract Diseases / Q000503:physiopathology; D002766:Cholecystokinin / Q000494:pharmacology*; D004386:Duodenum / Q000502:physiology*; D010450:Endopeptidases / Q000378:metabolism*; D004765:Enteropeptidase / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D007419:Intestinal Secretions / Q000032:analysis / Q000201:enzymology*; D010179:Pancreas / Q000503:physiopathology; D010182:Pancreatic Diseases / Q000503:physiopathology; D012633:Secretin / Q000494:pharmacology*; D014357:Trypsin / Q000032:analysis
D001647:Bile Acids and Salts; D012633:Secretin; D002766:Cholecystokinin; D010450:Endopeptidases; D014357:Trypsin; D004765:Enteropeptidase