Balance of DNA and protein syntheses, processes of stabilization and repair of breaks in DNA strands, and cell viability.
The dependence of the stabilization and repair of breaks in the DNA strands on the balance of the syntheses of DNA and protein and the relationship of these processes to the viability of E. coli cells were experimentally substantiated. It was established that equilibrium of the rates of DNA and protein syntheses is a necessary condition for the functioning of processes of DNA repair. "Imbalanced" breaks in the DNA strands in vivo are a consequence of a sharp decrease in the effectiveness of DNA repair processes.
D001426:Bacterial Proteins / Q000096:biosynthesis*; D002470:Cell Survival; D004260:DNA Repair; D004269:DNA, Bacterial / Q000096:biosynthesis*; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism* / Q000528:radiation effects; D005720:Gamma Rays; D008741:Methyl Methanesulfonate / Q000494:pharmacology; D009268:Nalidixic Acid / Q000494:pharmacology; D009691:Nucleic Acid Denaturation; D013941:Thymine / Q000378:metabolism
D001426:Bacterial Proteins; D004269:DNA, Bacterial; D009268:Nalidixic Acid; D008741:Methyl Methanesulfonate; D013941:Thymine