[Selective inhibition of ribosomal RNA synthesis by rifampicin in E. coli cells].
Under partial inhibition of total RNA synthesis by rifampicin the formation of beta- and beta'-subunits of RNA polymerase is stimulated and the rRNA synthesis is selectively repressed. The differential rate of synthesis of the beta- and beta'-subunits increases from 1,15% up to 2,88% in the presence of 30 micrograms rifampicin per ml. Simultaneously the differential rate of rRNA synthesis decreases from 41% down to 10%. The degree of inhibition of rRNA synthesis by rifampicin depends on the cell growth rate.
D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism*; D046911:Macromolecular Substances; D012335:RNA, Ribosomal / Q000096:biosynthesis*; D012293:Rifampin / Q000494:pharmacology*; D014158:Transcription, Genetic / Q000187:drug effects
D046911:Macromolecular Substances; D012335:RNA, Ribosomal; D012321:DNA-Directed RNA Polymerases; D012293:Rifampin
Izbiratel'noe podavlenie sinteza ribosomnoĭ RNK rifampitsinom v kletkakh E. Coli.