Hepatic clearance measurements and pharmacokinetics.
This review emphasizes the need for well-defined models for hepatic pharmacokinetics and discusses the interpretation of hepatic clearance measurements. Such recent approaches are subjected to theoretical and experimental comparisons. The pharmacokinetic consequences, including a classification of drugs according to hepatic clearance, are outlined.
D006801:Humans; D007700:Kinetics; D008099:Liver / Q000378:metabolism*; D008102:Liver Circulation; D008107:Liver Diseases / Q000378:metabolism; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000378:metabolism*
D004364:Pharmaceutical Preparations