Prolongation of murine skin allografts across a major histocompatibility locus using supernatants from con-A activated spleen cells.
Supernatants from Concanavalin A-activated mouse spleen cell cultures have been found to prolong skin graft survival across the H-2 locus in the mouse. There exist in these supernatants non-specific factors synthesized by suppressor T cells which have been activated by sub-optimal concentrations of Concanavalin A in vitro. The possible nature of these factors is discussed.
D000818:Animals; D003208:Concanavalin A / Q000494:pharmacology*; D006085:Graft Survival / Q000187:drug effects*; D008285:Major Histocompatibility Complex; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D016038:Skin Transplantation; D013154:Spleen / Q000166:cytology / Q000187:drug effects*; D014184:Transplantation, Homologous
D003208:Concanavalin A