Bile acid inhibition of Clostridium botulinum.
Bile acids and their glycine and taurine conjugates were tested in vitro for inhibition of Clostridium botulinum types A and B. Cholic acid inhibited most strains at 2 mg/ml, whereas chenodeoxycholic acid inhibited all strains at 0.4 mg/ml. Deoxycholic acid inhibited one strain at 0.08 mg/ml and other strains at 0.4 and 2 mg/ml. Lithocholic acid inhibited all strains at 0.016 mg/ml. Glycine conjugates also showed considerable inhibition of some strains, whereas taurine conjugates were inactive.
D001647:Bile Acids and Salts / Q000494:pharmacology*; D002793:Cholic Acids / Q000494:pharmacology; D003014:Clostridium botulinum / Q000187:drug effects* / Q000254:growth & development; D006801:Humans; D013654:Taurine / Q000494:pharmacology
D001647:Bile Acids and Salts; D002793:Cholic Acids; D013654:Taurine