Low dose steroid from the day following renal transplantation.
Azathioprine combined with a low dose of steroid (20mg of prednisolone) commencing the day following transplantation has been used for immunosuppression for 151 consecutive renal transplants in 141 patients (146 cadaver grafts, 5 living related donor grafts). Immunosuppression was satisfactory as 109 grafts function from 6 months to 10 years, 17 of 42 grafts lost failed from rejection. No patient died from infection before 90 days, 4 died later from infection, 2 associated with anti-rejection therapy. Seven patients developed gastrointestinal complications, 1 died; 4 developed diabetes, all survived; only 1 patient developed avascular necrosis of bone.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001379:Azathioprine / Q000627:therapeutic use; D002493:Central Nervous System Diseases / Q000401:mortality; D002648:Child; D003110:Colonic Neoplasms / Q000401:mortality; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005767:Gastrointestinal Diseases / Q000401:mortality; D006084:Graft Rejection; D006331:Heart Diseases / Q000401:mortality; D006621:Hip Joint / Q000503:physiopathology; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use; D007166:Immunosuppressive Agents; D016030:Kidney Transplantation; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use*; D011655:Pulmonary Embolism / Q000401:mortality; D013997:Time Factors
D007166:Immunosuppressive Agents; D011239:Prednisolone; D001379:Azathioprine; D006854:Hydrocortisone