Synthesis and antimicrobial action of some bis-thiazolidines.
alpha, delta-Bis(thiazolidinidione-2,4-hydrazone-4-yl-3)butane (1) was reacted with heterocyclic and aromatic aldehydes in boiling glacial acetic acid, where the corresponding analogs of alpha, delta-bis (thiazolidindione-2,4-N-arylidenehydrazone-4-yl-3)butane (2) were separated. While with some other heterocyclic and aromatic aldehydes, and under the same conditions, the corresponding analogs of alpha, delta-bis(thiazolidinidione-2,4-N-arylidenehydrazone-4-arylidene-5-yl-3) butane (3) were obtained. The synthesized compounds exhibit antimicrobial activity.
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis*; D001419:Bacteria / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D013844:Thiazoles