[Segregation of HLA haplotypes in a family with infants having spina bifida].
The search for HLA association in spina bifida is particularly interesting since this condition can be associated with the effect of the T locus in mice. Gene and haplotype frequencies in 32 unrelated patients suffering from spina bifida were studied. Patients and families were examined clinically and radiologically. A high frequency of spina bifida occulta and other vertebral abnormalities was found suggesting genetic determinism but no evidence of linkage with HLA genes or haplotypes was found.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D005796:Genes; D008040:Genetic Linkage; D005838:Genotype; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D007223:Infant; D008297:Male; D010641:Phenotype; D016136:Spina Bifida Occulta / Q000235:genetics*
D006680:HLA Antigens
Recherche d'une segregation des haplotypes HLA dans une etude familiale d'enfants atteints de spina bifida.