Dantrolene and suxamethonium. The effect of pre-operative dantrolene on the action of suxamethonium.
A single oral dose of dantrolene (100--150 mg) given at least 2 hr pre-operatively has been found to reduce significantly the strength of muscular fasciculations, the hyperkalaemia and the incidence of muscle pains following suxamethonium (from 56 to 4%) in a series of forty-eight patients compared with controls. The biceps EMG of the fasciculations was unchanged by dantrolene; the incidence of troublesome side effects was low (9%) and there did not appear to be any alteration in the duration of action of suxamethonium.
D000328:Adult; D002986:Clinical Trials as Topic; D003620:Dantrolene / Q000627:therapeutic use*; D004347:Drug Interactions; D005207:Fasciculation / Q000139:chemically induced / Q000517:prevention & control*; D005260:Female; D006801:Humans; D006827:Hydantoins / Q000627:therapeutic use*; D009069:Movement Disorders / Q000517:prevention & control*; D010149:Postoperative Pain / Q000139:chemically induced / Q000517:prevention & control*; D011188:Potassium / Q000097:blood; D011229:Preanesthetic Medication; D011897:Random Allocation; D013390:Succinylcholine / Q000009:adverse effects*; D013997:Time Factors
D006827:Hydantoins; D003620:Dantrolene; D013390:Succinylcholine; D011188:Potassium