[Change of toxic and antineoplastic properties of ftorafur by means of action on nonspecific microsomal oxidase].
The inducers of microsomal hydroxylases, phenobarbitone and methylcholanthrene, inhibited the development of neurotoxic shock provoked by high doses of ftorafur in mice, but stimulated the animal mortality on the 4th-8th day after the drug administration. The opposite effect on both toxicity manifestations has been obtained under the action of the inhibitor SKF 525-A. Pretreatment of the animals with phenobarbitone or phenobarbitone-methylcholanthrene combination markedly increased the antineoplastic activity of ftorafur determined by a loss of the spleen weight in mice infected with Rauscher's leukemia.
D000818:Animals; D004336:Drug Antagonism; D004357:Drug Synergism; D004790:Enzyme Induction; D005472:Fluorouracil / Q000031:analogs & derivatives*; D007942:Leukemia, Experimental / Q000188:drug therapy*; D008748:Methylcholanthrene / Q000627:therapeutic use; D051379:Mice; D008861:Microsomes / Q000201:enzymology*; D010088:Oxidoreductases / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D010634:Phenobarbital / Q000627:therapeutic use; D011292:Premedication; D011335:Proadifen / Q000627:therapeutic use; D011925:Rauscher Virus; D013154:Spleen / Q000473:pathology*; D005641:Tegafur / Q000633:toxicity*
D005641:Tegafur; D008748:Methylcholanthrene; D011335:Proadifen; D010088:Oxidoreductases; D005472:Fluorouracil; D010634:Phenobarbital
Izmenenie toksicheskikh i protivoopukholevykh svoĭstv ftorafura putem vozdeĭstviia na nespetsificheskie oksidazy mikrosom.