Cell population kinetic profile of the mouse thymus, and the changes induced by prednisolone.
The cell population kinetic parameters of the thymus in BALB/c mice have been estimated using stathmokinetic and [3H]TdR techniques in both control animals and animals treated with prednisolone. FLM data were analysed by computer using the Gilbert program. The study showed that prednisolone had an inhibitory effect mainly in the DNA synthesis phase and in G1. Stathmokinetic data also showed a decrease in the cell birth rate and an increase in the apparent cell cycle time (or potential doubling time) after treatment. The labelling index, the mitotic index and the growth fraction were also decreased. The study also shows a good agreement between the data obtained by stathmokinetic and [3H]TdR techniques.
D000818:Animals; D002453:Cell Cycle / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis; D005260:Female; D007700:Kinetics; D008433:Mathematics; D051379:Mice; D008807:Mice, Inbred BALB C; D008940:Mitotic Index / Q000187:drug effects; D011239:Prednisolone / Q000494:pharmacology*; D013950:Thymus Gland / Q000166:cytology* / Q000187:drug effects
D004247:DNA; D011239:Prednisolone