Synaptosomal accumulation of intracerebrally injected amino acids.
The distribution of the labels of [35S]taurine, [3H]lysine, [14C]glutamate and [14C]norleucine in mouse brain subcellular fractions was followed after intracerebral injection in vivo. [35S]taurine, [3H]lysine and [14C]glutamate and its metabolites accumulated in the nerve terminals, lysine and glutamate also occurring in the synaptic vesicles, while remained mainly in soluble synaptoplasm [14C] nor leucine penetrated the brain cell membranes slowly, but was still bound to the synaptic vesicles to a greater extent than taurine.
D000596:Amino Acids / Q000008:administration & dosage / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D005260:Female; D007276:Injections, Intraventricular; D051379:Mice; D013574:Synaptosomes / Q000378:metabolism*
D000596:Amino Acids