Morphologic effects of thio-TEPA on mouse urothelium.
The urothelial changes induced by intravesical instillation of thio-TEPA into experimental animals were studied by cytologic, light microscopic, and electron microscopic techniques. Cells and tissue from treated and untreated groups were compared using a total of 54 discriminators. There were few consistent differences. Cells with marked nuclear atypia were not identified. The results indicate that thio-TEPA has little effect on non-diseased bladders. The atypical cells occasionally present in specimens from thio-TEPA treated bladders apparently do no emanate from normal urothelium.
D000818:Animals; D005260:Female; D051379:Mice; D008854:Microscopy, Electron; D013852:Thiotepa / Q000494:pharmacology*; D001743:Urinary Bladder / Q000166:cytology / Q000187:drug effects* / Q000648:ultrastructure
D013852:Thiotepa