Accidental self-inoculation with killed Mycobacterium tuberculosis in Freund's complete adjuvant.
The case is described of a laboratory worker who was carrying out an animal immunological experiment and accidentally punctured the palm of his hand with Freund's complete adjuvant which contained heat-killed M. tuberculosis in a paraffin emulsion. A serious localised chronic tuberculoid granulomatous reaction developed which persisted for nine months. The significance of this phenomenon is discussed and the importance of the prevention of such an occurrence is emphasized.
D000062:Accidents, Occupational; D000328:Adult; D005620:Freund's Adjuvant / Q000506:poisoning*; D006099:Granuloma / Q000209:etiology; D006801:Humans; D008297:Male; D009169:Mycobacterium tuberculosis; D014375:Tuberculoma / Q000209:etiology
D005620:Freund's Adjuvant