Genetic linkage relations of the sixth component of complement (C6).
Linkage relations between the C6 and 33 other genetic marker loci have been analyzed in Norwegian pedigrees, including 114 matings with 388 informative children, by use of the MOSM computer program. No suggestion of linkage was found. Very close or close linkage (theta less than 0.06) has been ruled out for males between C6 and the following 19 marker loci: GPT, HLA + Bf, Rh, C3, Hp, PGM3, Km, Gm, Fy, Gc, ABO Jk, GLO1, K, MNSs, PTC, ACP1, PGM1, and Pi. For several of the relations even loose-linkage is unlikely.
D000328:Adult; D001789:Blood Group Antigens / Q000235:genetics; D002648:Child; D003183:Complement C6 / Q000235:genetics*; D003201:Computers; D004798:Enzymes / Q000235:genetics; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D005796:Genes; D008040:Genetic Linkage; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D007136:Immunoglobulins / Q000235:genetics; D007962:Leukocytes / Q000201:enzymology; D008297:Male; D009664:Norway
D001789:Blood Group Antigens; D003183:Complement C6; D004798:Enzymes; D006680:HLA Antigens; D007136:Immunoglobulins