Effect of ethynodiol diacetate with ethinyl estradiol on the mammary glands of rhesus monkeys: a preliminary report.
The oral contraceptive combination of ethynodiol diacetate with ethinyl estradiol (Demulen) was given cyclically to 48 female rhesus monkeys for 5 years. Doses employed were 1, 10, and 50 times the human dose. Treatment did not induce palpable breast nodules, and there were no deaths from mammary gland cancer.
D000818:Animals; D004347:Drug Interactions; D004997:Ethinyl Estradiol / Q000008:administration & dosage / Q000009:adverse effects*; D005040:Ethynodiol Diacetate / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D000882:Haplorhini; D008253:Macaca mulatta; D008321:Mammary Glands, Animal / Q000187:drug effects* / Q000378:metabolism; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced*; D013997:Time Factors
D004997:Ethinyl Estradiol; D005040:Ethynodiol Diacetate