[An immunological enhancement phenomenon in different experimental bacterial infections].
To demonstrate that an enhancement phenomenon might be involved during the development of bacterial infections, one has to establish that specific humoral antibodies protect, in some way, microorganisms against the defence reations of the host. This report presents the evidence that specific antibodies could be evolved in assuming a certain survival of bacterial cells in host's tissue. (1) Homologues antistaphylococcal sera passively potentiated the development of experimental staphylococcal synovitis infection of chickens. The enhancement activity of the antisera was associated with a relatively high level of immune adherence antibodies and seemed not be correlated with their agglutinin titers. (2) The passive transfer of chicken anti-Brucella immune globulins promote the survival of B. abortus in the spleen of chickens infected with these bacteria. This enhancing effect was reduced significantly when the immune globulins were absorbed with heat-killed Brucella cells to remove all the anti-Brucella agglutinins and immune adherence antibodies. (3) The passive transfer of rabbit antimycobacterial immunoglobulins directed against either living or soluble extracts of Mycobacterium tuberculosis strain H37Rv, promotes the multiplication of the BCG stain of M. tuberculosis in the spleen of mice infected with low doses of this latter strain. This enhancing effect was reduced significantly when antisera were absorbed with living BCG. Morever, such treatment led to the removal of all haemagglutinating antibodies when antisera were tested aganist either BCG or H37Rv soluble extracts.
D000818:Animals; D000917:Antibody Formation; D001500:BCG Vaccine; D001424:Bacterial Infections / Q000276:immunology*; D002003:Brucella abortus / Q000276:immunology; D002645:Chickens; D006801:Humans; D051379:Mice; D009164:Mycobacterium Infections / Q000276:immunology; D009163:Mycobacterium bovis / Q000276:immunology; D013203:Staphylococcal Infections / Q000276:immunology; D013211:Staphylococcus aureus / Q000276:immunology*
D001500:BCG Vaccine
Rôle d'anticorps facilitants dans le développement de différentes infections bactériennes expérimentales