Antibacterial activity of antibiotics in acrylic bone cement.
The release of various penicillins and other antibiotics from two brands of polymerised bone cement has been studied in vitro and in vivo in mice. Bone cement plugs containing antibiotics demonstrated antibacterial activity as a result of diffusion of antibiotic from the plugs into the surrounding medium. With all antibiotics tested, from 2-5 to 10 per cent of the antibiotic in the cement was released in vitro in active form within twenty-four hours. Most of the activity appeared within three hours of the start of the test, but in some cases low levels of activity were detected after four days. Antibiotic cement plugs implanted in mice and rats produced low concentrations of antibiotic in the blood up to two hours after implantation, but activity was seldom detected subsequently. In general, penicillins and non-penicillin antibiotics showed similar diffusion characteristics, and the pattern of release in vitro and in vivo was consistent with the leaching of antibiotic from, or near, the surface of the bone cement.
D000180:Acrylic Resins; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001419:Bacteria / Q000187:drug effects*; D001843:Bone Cements; D002509:Cephaloridine / Q000494:pharmacology; D002981:Clindamycin / Q000494:pharmacology; D004058:Diffusion; D004926:Escherichia coli / Q000187:drug effects; D005839:Gentamicins / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D010406:Penicillins / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D051381:Rats; D013211:Staphylococcus aureus / Q000187:drug effects; D013997:Time Factors
D000180:Acrylic Resins; D000900:Anti-Bacterial Agents; D001843:Bone Cements; D005839:Gentamicins; D010406:Penicillins; D002981:Clindamycin; D002509:Cephaloridine