In vitro stimulation of primate hemoglobin synthesis by L-thyroxine.
Bone marrow cells from adult and abortus primates (marmosets) were incubated in vitro to determine their responsiveness to L-thyroxine. 3H-leucine incorporation into purified globin chains was the parameter assayed to determine responsiveness. Bone marrow from spontaneously aborted animals consistently was stimulated by the presence of physiologic levels of L-thyroxine. Bone marrow cells from adult animals were unaffected by the hormone.
D000818:Animals; D001853:Bone Marrow / Q000032:analysis; D002143:Callitrichinae; D005260:Female; D005914:Globins / Q000096:biosynthesis; D000882:Haplorhini; D006454:Hemoglobins / Q000096:biosynthesis*; D011247:Pregnancy; D013268:Stimulation, Chemical; D013974:Thyroxine / Q000494:pharmacology*; D013997:Time Factors
D006454:Hemoglobins; D005914:Globins; D013974:Thyroxine