Cold agglutinins in a case of chronic lymphatic leukaemia. A study of the lymphocyte surface.
A case of chronic lymphatic leukaemia with cold agglutinins is presented in which peripheral blood lymphocytes of varying maturity appeared to possess T- and B-cell markers. A cold agglutinin IgM in type is identified in the serum and at the cell surface. This seems to be responsible for the spontaneous rosetting of sheep red blood cells (SRBC); A single clonal origin of these cells is suggested with maturation arrest. It is also suggested that with configurational change in lymphocyte surface cryoglobulins may sometimes produce spontaneous rosetting with SRBC.
D000373:Agglutinins; D001323:Autoantibodies; D002462:Cell Membrane / Q000276:immunology; D003080:Cold Temperature; D005455:Fluorescent Antibody Technique; D006801:Humans; D007104:Immune Adherence Reaction; D007075:Immunoglobulin M; D007945:Leukemia, Lymphoid / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D008875:Middle Aged
D000373:Agglutinins; D001323:Autoantibodies; D007075:Immunoglobulin M