3-Aminotetrahydrocarbazoles as a new series of central nervous system agents.
3-Dimethylamino-1,2,3,4-tetrahydrocarbazole, a structurally modified tryptamine, prevented amphetamine-induced stereotyped behavior in rats and prevented reserpine-induced ptosis in mice. Further study of this compound and a number of substituted derivatives indicated that either imipramine-like or chlorpromazine-like profiles were obtainable by changing substituents and their positions.
D000661:Amphetamine / Q000037:antagonists & inhibitors; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001763:Blepharoptosis / Q000139:chemically induced / Q000517:prevention & control; D002227:Carbazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D002490:Central Nervous System / Q000187:drug effects*; D000882:Haplorhini; D006801:Humans; D008253:Macaca mulatta; D008297:Male; D051379:Mice; D051381:Rats; D012110:Reserpine / Q000037:antagonists & inhibitors; D013239:Stereotyped Behavior / Q000187:drug effects; D013329:Structure-Activity Relationship; D014839:Vomiting / Q000139:chemically induced / Q000517:prevention & control
D002227:Carbazoles; D012110:Reserpine; D000661:Amphetamine; D001058:Apomorphine