Morphine ingestion: genetic control in mice.
C57BL/6J mice will drink large amounts of, and display a highly positive preference for, morphine sulfate when it is dissolved in an aqueous solution of sodium saccharin. In identical test situations DBA/2J mice will drink very little of, and display a strong avoidance toward, the morphine-saccharin solution. This clear separation between morphine-accepting and morphine-rejecting animals within a single species combined with a quick and simple method of inducing high levels of morphine ingestion could facilitate the discovery of causal factors in opiate addiction.
D000818:Animals; D005838:Genotype; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009020:Morphine / Q000008:administration & dosage*; D012439:Saccharin / Q000008:administration & dosage; D012646:Self Administration; D013045:Species Specificity; D013997:Time Factors
D009020:Morphine; D012439:Saccharin