Bioavailability of conventional and slow-release oxprenolol in fasted and nonfasted individuals.
1 The influence of food and plasma levels of oxprenolol was examined in healthy female volunteers using both conventional and slow-release formulations. 2 There were no significant trends in plasma drug profiles due to food with either formulation. Elimination half-lives were longer after food with conventional tablets, presumably due to continued absorption. The opposite effect was seen with slow-release tablets. 3 Slow-release oxprenolol is, under the conditions of this study, a reliable and convenient dosage form, providing similar plasma-drug profiles in fasted and nonfasted individuals.
D000328:Adult; D001682:Biological Availability; D003692:Delayed-Action Preparations; D005215:Fasting; D005260:Female; D006801:Humans; D007700:Kinetics; D010096:Oxprenolol / Q000008:administration & dosage / Q000378:metabolism*; D013997:Time Factors
D003692:Delayed-Action Preparations; D010096:Oxprenolol