title: Potent antidopaminergic activity of estradiol at the pituitary level on prolactin release.
abstract: Prior incubation of rat anterior pituitary cells with 17beta-estradiol led to an almost complete reversal of the inhibitory effect of two dopamine agonists, dihydroergocornine and RU 24213, on both basal prolactin release and thyrotropin releasing hormone-induced prolactin release. These experiments thus demonstrate a direct interference of dopamine action by a peripheral hormone. Prolactin secretion by pituitary cells in primary culture could possibly serve as an easily accessible model of a system under dopaminergic control.
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D004088:Dihydroergotoxine / Q000037:antagonists & inhibitors; D018492:Dopamine Antagonists; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D010627:Phenethylamines / Q000037:antagonists & inhibitors; D010903:Pituitary Gland, Anterior / Q000187:drug effects* / Q000378:metabolism; D011388:Prolactin / Q000378:metabolism*; D051381:Rats; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology
chemical_list: D018492:Dopamine Antagonists; D010627:Phenethylamines; D004088:Dihydroergotoxine; D004958:Estradiol; D013973:Thyrotropin-Releasing Hormone; C016868:N-n-propyl-N-phenylethyl-4(3-hydroxyphenyl)ethylamine hydrochloride; D011388:Prolactin