title: The Nb rat: prostatic adenocarcinoma model.
abstract: The Noble rat prostatic adenocarcinoma is an animal model which is used to study human prostatic carcinoma. It mimics the human condition in histology, in biochemistry with the production of acid phosphatase, and in tumor growth which is relatively constant. Additionally, it is hormonally dependent and metastasizes. This animal model should provide an avenue for the evaluation of cytotoxic chemotherapeutic agents heretofore receiving little attention from the urologic community.
mesh_terms: D000230:Adenocarcinoma / Q000139:chemically induced / Q000201:enzymology / Q000473:pathology*; D000728:Androgens / Q000378:metabolism; D000818:Animals; D004195:Disease Models, Animal; D004967:Estrogens / Q000378:metabolism; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation; D011471:Prostatic Neoplasms / Q000139:chemically induced / Q000201:enzymology / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D000728:Androgens; D004967:Estrogens