Cholinergic inhibition of methylphenidate-induced stereotypy: oxotremorine.
Lethality of orally administered oxotremorine for female mice required 250 times the dose that was effective for inhibiting methylphenidate-induced stereotypy. A number of lines of evidence indicate that increasing central cholinergic activity may be useful in various psychiatric syndromes and movement disorders. A relatively safe oral cholinomimetic would be clinically useful. Oxotremorine may be such an agent.
D000818:Animals; D001519:Behavior / Q000187:drug effects*; D005260:Female; D006801:Humans; D007928:Lethal Dose 50; D008774:Methylphenidate / Q000037:antagonists & inhibitors*; D051379:Mice; D010095:Oxotremorine / Q000494:pharmacology* / Q000633:toxicity; D013239:Stereotyped Behavior / Q000187:drug effects*; D013997:Time Factors
D008774:Methylphenidate; D010095:Oxotremorine