title: Pharmacokinetics of amoxicillin: Dosage nomogram for patients with impaired renal function.
abstract: Amoxicillin pharmacokinetics after intravenous administration were studied in patients with normal renal function, with impaired renal function, and during hemodialysis. The average urinary recovery was 68% in patients with normal renal function. Serum half-life was highly correlated (r = 0.967) with creatinine clearance corrected for body weight. Expected half-life was 71 min for a corrected creatinine clearance of 100 ml/min per 70 kg and 16 h in the anephric patient. Average amoxicillin half-life on hemodialysis was 3.6 h. We present a dosage nomogram for making appropriate adjustments to loading dose based on patient weight and maintenance dose based on corrected creatinine clearance.
mesh_terms: D000658:Amoxicillin / Q000008:administration & dosage / Q000378:metabolism*; D000667:Ampicillin / Q000031:analogs & derivatives*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007275:Injections, Intravenous; D007676:Kidney Failure, Chronic / Q000378:metabolism*; D007677:Kidney Function Tests
chemical_list: D000667:Ampicillin; D000658:Amoxicillin