[Effect of some phosphonic amino acids on the activity of central neurons].
Microiontophoretic applications of DL-2-amino-3-phosphonopropionic, DL-3-amino-4-phosphonobutyric, aminomethylphosphonic, 2-aminoethylphosphonic and 3-aminopropylphosphonic acids in the course of extracellular recordings of central neurons in the Rat resulted in effects which appeared similar to those observed with their carboxylic analogs. The involvement of the same post-synaptic receptors is suggested.
D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D002531:Cerebellum / Q000502:physiology; D002540:Cerebral Cortex / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D063065:Organophosphonates / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D000596:Amino Acids; D063065:Organophosphonates; D005680:gamma-Aminobutyric Acid
Effets de quelques acides aminés phosphoniques sur l'activité de neurones centraux.