Autoimmune hemolytic anemia in association with monoclonal IgM(kappa) with anti-i activity.
A patient with a warm autoimmune hemolytic anemia with an immunoglobulin G (IgG) panagglutinin, also had monocional IgM(kappa) cold agglutinin with anti-i activity. Ninety per cent of the peripheral blood lymphocytes had surface immunoglobulin and the number of T cells was diminished. A subpopulation of the patient's lymphocytes formed rosettes with cord (i) erythrocytes and not with adult (l) erythrocytes. The finding of increased lymphocytes bearing i-binding sites and a monoclonal antibody with anti-i activity could be related to shared idiotypic determinants between antigen-binding sites and serum antibody. The occurrence of two autoantibodies in this patient suggests an immune regulatory disorder.
D000744:Anemia, Hemolytic, Autoimmune / Q000097:blood* / Q000276:immunology; D001789:Blood Group Antigens; D006801:Humans; D007048:I Blood-Group System; D007147:Immunoglobulin Light Chains / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis*; D007145:Immunoglobulin kappa-Chains / Q000032:analysis*; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D008875:Middle Aged
D001789:Blood Group Antigens; D007048:I Blood-Group System; D007147:Immunoglobulin Light Chains; D007075:Immunoglobulin M; D007145:Immunoglobulin kappa-Chains