title: Low molecular weight (7S) IgM and free light chains in the sera of patients with the tropical splenomegaly syndrome.
abstract: The presence of naturally occurring LMW (7S) IgM was suspected on Sephadex G-200 filtration of a serum pool from patients with tropical splenomegaly syndrome (TSS). It was found in nineteen out of thirty-one sera from these patients using a polyacrylamide/agarose gel-diffusion  method, and in fifteen of the sera after precipitation of the 19S IgM with 10% polyethylene glycol (PEG). Free K-light chains was detected in twenty-five out of thirty-one sera from patients with the TSS while free lambda-light chains was detected in four. The presence of 7S IgM and free light chains in sera of these patients is in keeping with our hypothesis that there is a disorder of control of immunoglobulin production in the tropical splenomegaly syndrome.
mesh_terms: D002850:Chromatography, Gel; D006801:Humans; D005779:Immunodiffusion; D007147:Immunoglobulin Light Chains / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis*; D008970:Molecular Weight; D013163:Splenomegaly / Q000276:immunology*; D014329:Tropical Climate
chemical_list: D007147:Immunoglobulin Light Chains; D007075:Immunoglobulin M