title: An active center tryptophan residue in dihydrofolate reductase: chemical modification, sequence surrounding the critical residue, and structural homology considerations.
mesh_terms: D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D001665:Binding Sites; D001974:Bromosuccinimide / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D007780:Lacticaseibacillus casei / Q000187:drug effects / Q000201:enzymology*; D008727:Methotrexate / Q000494:pharmacology; D013762:Tetrahydrofolate Dehydrogenase / Q000378:metabolism; D014364:Tryptophan / Q000032:analysis*
chemical_list: D000596:Amino Acids; D014364:Tryptophan; D013762:Tetrahydrofolate Dehydrogenase; D001974:Bromosuccinimide; D008727:Methotrexate