Stereotypy and hyperactivity in rats receiving ethanol and a monoamine oxidase inhibitor.
The combined administration of tranylcypromine (TCP) and ethanol to rats produced both a marked increase in general locomotion such as walking and running and the appearance of repetitive stereotyped head and trunk weaving, forepaw padding, and circling movements. Pretreatment with p-chlorophenylalanine (pCPA) abolished the stereotyped behaviors. In contrast, animals pretreated with alpha-methyl-p-tyrosine (AMPT) were virtually indistinguishable from those receiving only TCP + ethanol, except for a decrease in running behaviors. The above results are consistent with a serotonergic mediation of these specific stereotypes. The mechanisms by which TCP + ethanol might produce these effects are discussed.
D000818:Animals; D001519:Behavior / Q000187:drug effects*; D000431:Ethanol / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects*; D014191:Tranylcypromine / Q000494:pharmacology*
D008781:Methyltyrosines; D014191:Tranylcypromine; D000431:Ethanol