Effect of insulin on immunological phagocytosis by macrophages.
It was shown that, in physiological concentrations, insulin enhances, in vitro, the immunological phagocytosis of sensitized sheep erythrocytes by cultured mouse peritoneal macrophages. Insulin seems to stimulate macrophage phagocytosis as a cholinomimetic agonist by increasing the intracellular levels of cyclic GMP.
D000818:Animals; D001665:Binding Sites; D005260:Female; D007328:Insulin / Q000494:pharmacology*; D007329:Insulin Antagonists; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology / Q000502:physiology; D051379:Mice; D009712:Nucleotides, Cyclic / Q000378:metabolism; D010587:Phagocytosis / Q000187:drug effects*; D013268:Stimulation, Chemical
D007328:Insulin; D007329:Insulin Antagonists; D009712:Nucleotides, Cyclic