title: [Effect of potassium-hydrogen interaction in the excretory mechanism of the kidneys on the acid-base and other biochemical values of the blood and urine in calves].
abstract: The effect of the competitive relationship between potassium and hydrogen in the excretory mechanism of the kidneys on metabolism was studied in calves. The intraruminal exposure of calves to 5.6 meq potassium chloride (KCl) per kg per day has, in itself, only a slight acidotic effect ascribable to a slight reduction of the excretion of acid by the kidney. The same dose of ammonium chloride (NH4Cl) has a strong acidotic effect combined with a negative influence on weight gain. Both basic types of exposure increase the concentration of inorganic phosphorus and reduce the concentration of chlorine in the blood serum. The addition of 2.8 meq of potassium chloride per kg per day to the basic dose of ammonium chloride increases metabolic acidosis, worsens the health condition (being, at times, hazardeous to life) and leads to weight losses. The same amount of ammonium chloride added to the basic dose of ammonium chloride has a relatively small acidotic action on the blood, evoking only a slight and temporary potassium retention in the serum. The negative action on the weight gains and clinical symptoms are generally weaker than in the other group. The results indicate that the acidotic environment creates in ruminants a very dangerous situation if the organism is excessively exposed to the effect of potassium at the same time.
mesh_terms: D000136:Acid-Base Equilibrium / Q000187:drug effects*; D000643:Ammonium Chloride / Q000494:pharmacology; D000818:Animals; D001823:Body Composition / Q000187:drug effects; D002417:Cattle / Q000378:metabolism*; D006859:Hydrogen / Q000494:pharmacology*; D007668:Kidney / Q000378:metabolism*; D008297:Male; D011189:Potassium Chloride / Q000494:pharmacology*
chemical_list: D000643:Ammonium Chloride; D011189:Potassium Chloride; D006859:Hydrogen
vernacular_title: Vliv interakce draslíku a vodíku v exkrecním mechanismu ledvin na acidobazické a jiné biochemické hodnoty krve a moci telat.