Liposome entrapped desferrioxamine and iron transporting ionophores: a new approach to iron chelation therapy.
Liposome-entrapped desferrioxamine was administered to iron-over-loaded 59Fe lavelled mice. When given orally or intraperitoneally entrapment did not enhance the effect of the chelator, but given intravenously liposomal desferrioxamine doubled the 59Fe excretion for a given dose of the drug, and excretion after a single dose continued for up to 3 d. In addition, liposomes containing ionophore A23187 administered concurrently with DTPA caused an excretion of 59Fe, whereas DTPA alone had no effect.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003676:Deferoxamine / Q000008:administration & dosage* / Q000494:pharmacology; D007275:Injections, Intravenous; D007501:Iron / Q000652:urine*; D007502:Iron Chelating Agents / Q000008:administration & dosage; D007832:Lasalocid / Q000494:pharmacology*; D008081:Liposomes; D051379:Mice; D004369:Pentetic Acid / Q000008:administration & dosage
D000900:Anti-Bacterial Agents; D007502:Iron Chelating Agents; D008081:Liposomes; D004369:Pentetic Acid; D007501:Iron; D003676:Deferoxamine; D007832:Lasalocid