Effect of betamethasone on analysis of amniotic fluid in the rhesus-sensitized pregnancy.
Betamethasone was administered to six rhesus-sensitized pregnant women carrying seven fetuses in an attempt to accelerate fetal pulmonary maturation. A reduction in optical density of amniotic fluid at 450 mmu was observed in all cases following steroid therapy; however, only minimal changes were noted in the lecithin-sphingomyelin ratio. The implications of these findings for the management of rhesus-sensitized pregnancies are discussed.
D000649:Amniocentesis; D000653:Amniotic Fluid / Q000032:analysis*; D001623:Betamethasone / Q000494:pharmacology*; D001787:Blood Group Incompatibility / Q000378:metabolism*; D005260:Female; D006801:Humans; D008168:Lung / Q000196:embryology; D010713:Phosphatidylcholines / Q000032:analysis; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000378:metabolism*; D012204:Rh-Hr Blood-Group System; D013053:Spectrophotometry; D013109:Sphingomyelins / Q000032:analysis
D010713:Phosphatidylcholines; D012204:Rh-Hr Blood-Group System; D013109:Sphingomyelins; D001623:Betamethasone