Safety of cefoxitin: an approach to the analysis of laboratory data.
The safety of cefoxitin, in terms of values obtained in laboratory tests during and after therapy, was estimated by three methods for analysis of data derived from controlled clinical comparisons of cephalothin and cefoxitin. Both antibiotics were found to be safe with respect to hematologic, renal, and hepatic function and did not differ significantly from each other. Laboratory data confirmed by tests performed serially and by paired related tests were analyzed by a novel method of comparison.
D002440:Cefoxitin / Q000009:adverse effects* / Q000627:therapeutic use; D002512:Cephalothin / Q000009:adverse effects* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008297:Male
D002440:Cefoxitin; D002512:Cephalothin