title: [Behavior of the serum titer after treatment with mebendazole in guinea-pigs infected with trichinella spiralis (author's transl)].
abstract: The behavior of the IFT serum titer in 80 guinea-pigs, experimentally infected with Trichinella spiralis, was tested before and after treatment with mebendazole for 6 months. For 14 consecutive days each animal was drenched with 40 mg mebendazole/kg bw on the 25th, 35th and 45th day after infection. After the 2 weeks therapy, living trichinella larvae were not found in any of the 3 treated groups of guinea-pigs. On the other hand even after 6 months viable larvae were found in the muscular tissue of the control animals. Within the first two months p.i. the titers were rising equally in both treated and untreated animals. Only then did the titer in the treated animals decrease markedly, whereas it fell gradually in the controls. After 6 months both groups were negative in the IFT.
mesh_terms: D000818:Animals; D001562:Benzimidazoles / Q000627:therapeutic use*; D005455:Fluorescent Antibody Technique; D006168:Guinea Pigs; D006386:Hemagglutination Tests; D008463:Mebendazole / Q000494:pharmacology / Q000627:therapeutic use*; D013997:Time Factors; D014234:Trichinella / Q000187:drug effects / Q000276:immunology*; D014235:Trichinellosis / Q000188:drug therapy
chemical_list: D001562:Benzimidazoles; D008463:Mebendazole
vernacular_title: Serumtiterverlauf bei Trichinella-spiralis-infizierten Meerschweinchen nach Behandlung mit Mebendazol.