[Changes in the immunologis status of the body during carcinogenesis detected by the physico-chemical characteristics of cells of the immunocompetent system].
The state of cell population of the lymph nodes and the thymus was studied on a model of rat sarcoma of the hip(induced by dimethlbenzanthracene) by the method of fluorescent sounds. Statistically significant changes of incorporation of the negatively charged sound 1-anilino-8-naphthalinosulfonate (ANS) into cell suspension, depending on the stage of sarcoma development, were detected. The appearance of cell forms with a lesser hydrophobic character of the surface and with less binding points for the ANS were noted at the early carcinogenesis periods. It is supposed that these cells were referred to immature ones. A conclusion was drawn on the applicability of the method of fluorescent sound for recording changes in the immunological state of the organism in carcinogenesis.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000817:Anilino Naphthalenesulfonates / Q000378:metabolism*; D000818:Animals; D001665:Binding Sites; D008198:Lymph Nodes / Q000378:metabolism; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D051381:Rats; D012513:Sarcoma, Experimental / Q000139:chemically induced / Q000276:immunology*; D013601:T-Lymphocytes / Q000378:metabolism; D013848:Thigh
D000817:Anilino Naphthalenesulfonates; D015127:9,10-Dimethyl-1,2-benzanthracene
Izmeneniia immunologicheskogo statusa organizma pri kantserogeneze, vyiavliaemye po fiziko-khimicheskim kharakteristikam kletok immunokompetentnoĭ sistemy