Primate model for long-term study of intraventricularly or intrathecally administered drugs and intracranial pressure.
Meaningful pharmacokinetic investigations require animal systems which approximate the human situation. This report describes a primate model in which silicone catheters are placed into the fourth ventricle and the spinal subarachnoid space and connected to subcutaneous cerebrospinal fluid without tissue damage, prod, enables spinoventricular perfusion, and permits ventricular cerebrospinal fluid sampling over extended periods in unanethetized rhesus monkeys. This animal system may provide intraventricular pressure recordings and pharmacokinetic data similar to that obtained in man.
D000818:Animals; D001702:Biopharmaceutics; D002404:Catheterization / Q000379:methods; D002552:Cerebral Ventricles / Q000502:physiology; D000882:Haplorhini; D007276:Injections, Intraventricular / Q000379:methods*; D007278:Injections, Spinal / Q000379:methods*; D007427:Intracranial Pressure; D008253:Macaca mulatta; D008727:Methotrexate / Q000134:cerebrospinal fluid; D013346:Subarachnoid Space / Q000502:physiology
D008727:Methotrexate