Possible role of dopamine in central effects of cocaine as measured by apomorphine gnawing test in mice.
Apomorphine (10mg/kg, s.c.) does not induce in mice a compulsion to gnaw, but pretreatment with cocaine (10-40 mg/kg, i.p.) caused gnawing activity. This effect of cocaine was inhibited by pretreatment with alpha-methyl-p-tyrosine, haloperidol, and physostigmine, but not with FLA-63, phenoxybenzamine and tetrabenazine. These findings would suggest that dopaminergic mechanism plays a significant role in the potentiation of apomorphine gnawing activity by cocaine and also support the view that inhibition of dopamine uptake is responsible for the stimulatory action of cocaine.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001519:Behavior / Q000187:drug effects*; D003042:Cocaine / Q000494:pharmacology*; D004298:Dopamine / Q000502:physiology*; D004357:Drug Synergism; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D009638:Norepinephrine / Q000502:physiology; D013239:Stereotyped Behavior / Q000187:drug effects*; D013997:Time Factors
D003042:Cocaine; D001058:Apomorphine; D004298:Dopamine; D009638:Norepinephrine