[Effect of surface-active agents on Mycobacterium tuberculosis and Mycobacterium bovis. Obtaining chromogenic mycobacteria].
In 18 strains of M. tuberculosis and M. bovis it has been possible to demonstrate the existence, in pure cultures, of elements able to grow in vitro in scotochromogenic mycobacteria. The experimental method used includes a dispersion, under shaking, of organisms in different surface-active agents. The chromogenic strains isolated during the experimentation are eugonic, and PAS- and INH-resistant. Their experimental virulence is different from that of tubercle bacillus. We discuss the signification of this dissociation phenomenon inductible by surface-active agents.
D000818:Animals; D006168:Guinea Pigs; D009161:Mycobacterium / Q000302:isolation & purification*; D009163:Mycobacterium bovis / Q000187:drug effects* / Q000378:metabolism / Q000472:pathogenicity; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000378:metabolism / Q000472:pathogenicity; D009170:Nontuberculous Mycobacteria / Q000302:isolation & purification* / Q000378:metabolism / Q000472:pathogenicity; D010860:Pigments, Biological / Q000096:biosynthesis; D012967:Sodium Dodecyl Sulfate / Q000494:pharmacology; D013501:Surface-Active Agents / Q000494:pharmacology*; D014774:Virulence
D010860:Pigments, Biological; D013501:Surface-Active Agents; D012967:Sodium Dodecyl Sulfate
Effet de substances tensio-actives sur Mycobacterium tuberculosis et Mycobacterium bovis. Obtention de mycobactéries chromogénes.