Synthesis and biological effect of the C-terminal pentapeptide amide of avian pancreatic hormone III (APP).
Model building studies and analogies drawn from peptides of similar biological activity have indicated that the C-terminus of avian pancreatic hormone III may possess significant biological information. To test this hypothesis, the C-terminal pentapeptide amide sequence has been synthesized by the Merrifield method. The synthesis, purification and characterization of this compound are reported here in detail. In vivo studies indicate that this synthetic segment possesses none of the secretogogic activity of the parent hormone; rather, it reduces "gastric" secretion levels even in the presence of the intact hormone.
D000577:Amides / Q000138:chemical synthesis* / Q000494:pharmacology; D000595:Amino Acid Sequence; D000818:Animals; D002645:Chickens; D005260:Female; D005750:Gastric Juice / Q000378:metabolism*; D010187:Pancreatic Hormones / Q000138:chemical synthesis*; D010455:Peptides / Q000138:chemical synthesis* / Q000494:pharmacology; D012636:Secretory Rate / Q000187:drug effects
D000577:Amides; D010187:Pancreatic Hormones; D010455:Peptides