[Effect of alpha-tocopherol on phospholipid concentration and lipid peroxidation in rat brain tissue following a burn injury].
Studies of the lipid peroxides and phospholipid content in the rat brain in different periods after burns showed that the total phospholipid content in all the periods is decreased. The daily intraperitoneal administration of alpha-tocopherol in a dose of 100 mg/kg against a background of the burn decreases sharply the phospholipid content. alpha-Tocopherol in a dose of 1 mg/kg, administered immediately after the trauma and then 3, 7, 12 and 17 days after burns restores the phospholipid content to normal. The described changes were connected mainly with the lecithin and phosphatidylethanolamine fractions.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry; D002056:Burns / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D050356:Lipid Metabolism; D010545:Peroxides / Q000096:biosynthesis; D010743:Phospholipids / Q000032:analysis; D051381:Rats; D013997:Time Factors; D014810:Vitamin E / Q000627:therapeutic use*
D010545:Peroxides; D010743:Phospholipids; D014810:Vitamin E
Deĭstvie alpha-tokoferola na soderzhanie fosfolipidov i perekisnoe okislenie lipidov v tkani mozga krys posle ozhogovoĭ travmy.