title: Unilateral catecholamine depletion of the corpus striatum and amphetamine-induced turning: an ontogenetic study.
abstract: Unilateral intrastriatal microinjections of alpha-methyl-p-tyrosine followed by systemic amphetamine treatment produced turning ipsilateral to the side of the injection in rats from 12 days of age to maturity, but not in rats younger than 12 days. These results are consistent with other findings that indicate rapid development of the striatal dopaminergic system and dopaminergic component  of the amphetamine stereotypy in the second postnatal week.
mesh_terms: D000375:Aging; D000818:Animals; D001519:Behavior / Q000187:drug effects*; D002395:Catecholamines / Q000378:metabolism*; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D003913:Dextroamphetamine / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007267:Injections; D008297:Male; D008781:Methyltyrosines / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects*
chemical_list: D002395:Catecholamines; D008781:Methyltyrosines; D003913:Dextroamphetamine