Conditions favouring the selection of either specific or non specific C. parvum-mediated, systemic antitumour immunity in mice.
Accumulated data suggest that one of two antitumour mechanisms of C. parvum may predominate depending on the route of injection of C. parvum and its distribution in relation to the tumour. After systemic C. parvum the mechanism is considered to be immunologically non specific (i.e. not requiring tumour specific antigens) and mediated by C. parvum activated macrophages. After local injection of C. parvum the interaction (direct or lymph node mediated) between C. parvum and tumour specific antigens has resulted in the generation of immunologically specific T-lymphocytes with antitumour activity.
D000818:Animals; D066298:In Vitro Techniques; D007263:Infusions, Parenteral; D007279:Injections, Subcutaneous; D012515:Mast-Cell Sarcoma / Q000276:immunology; D051379:Mice; D009369:Neoplasms / Q000276:immunology*; D011425:Propionibacterium acnes / Q000276:immunology*; D012513:Sarcoma, Experimental / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology