Pre-estrogen breast irradiation for patients with carcinoma of the prostate: a critical review.
We studied 38 patients with prostatic cancer who received breast irradiation before oral estrogen administration. Our data are combined with those from other institutions to determine the effectiveness of pre-estrogen breast irradiation in minimizing gynecomastia and/or pain. Based on our review the incidence of estrogen-induced breast changes is 70%. Irradiation given before estrogen administration can prevent or minimize these changes in 89.3% of the treated patients. Histologic changes of gynecomastia are reviewed and recommendations for optimum radiation therapy technique are included.
D001940:Breast / Q000528:radiation effects*; D004054:Diethylstilbestrol / Q000009:adverse effects* / Q000627:therapeutic use; D005069:Evaluation Studies as Topic; D006177:Gynecomastia / Q000139:chemically induced* / Q000517:prevention & control; D006801:Humans; D008297:Male; D010146:Pain; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D011829:Radiation Dosage; D013997:Time Factors
D004054:Diethylstilbestrol