Structure--activity studies on tetrahydro- and hexahydrocannabinol derivatives.
A series of tetrahydro- and hexahydrocannabinol derivatives was prepared in which the substituents at position 9 were varied. These compounds were evaluated in mice for their effects on locomotor acitivty, body temperature, muscle tone, and analgesia. Depression of body temperature and locomotor function was demonstrated by several compounds, but all were devoid of any significant analgesic activity.
D000700:Analgesics / Q000138:chemical synthesis; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D002186:Cannabinoids / Q000138:chemical synthesis / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D013759:Dronabinol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D008297:Male; D051379:Mice; D009048:Motor Skills / Q000187:drug effects; D013329:Structure-Activity Relationship
D000700:Analgesics; D002186:Cannabinoids; D013759:Dronabinol