title: [Proteolytic activity of blood plasma and hemolysed blood in dogs after acute chlorophos poisoning].
abstract: On dogs under Eunarkon anesthesia (0,03 ml Eunarkon/kg body weight) after one intramuscular lethal injection of phoschlor (500 mg/lg body weight = LD100) the proteolytic activity (APR) was estimated in the blood plasma at pH 3,5-APR-3,5 and in the hemolyzed blood at pH-7,4-APR-7,4. The results showed that heavy poisoning with phoschlor led to metabolic disturbances in the proteolytic system of the blood plasma and blood, the expression of which was increasing in the course of time a statistically important increase (alpha = 0,001) of APR-3,5 and APR-7,4. APR induction in blood is not a result of direct activation of enzymes by pesticides. It takes place outside the circulation system.
mesh_terms: D000208:Acute Disease; D000818:Animals; D004285:Dogs; D006461:Hemolysis; D010447:Peptide Hydrolases / Q000097:blood*; D014236:Trichlorfon / Q000506:poisoning*
chemical_list: D014236:Trichlorfon; D010447:Peptide Hydrolases
vernacular_title: Aktywność proteolityczna w osoczu krwi i krwi hemolizowanej u psów po ostrym zatruciu foschlorem.