[Macrophage origin of platelet activating factor].
Platelet-activating factor (P.A.F.) is a mediator of anaphylaxis released from human and Rabbit basophils which causes aggregation of platelets and release of their vasoactive amines. We have induced the release of P.A.F. from Rat peritoneal cells (P.C.) with ionophore A 23187. After fractionation of P.C. on 5-15% Ficoll gradients, P.A.F. was obtained from macrophage-rich but not from mastocyte-rich fractions and from adherent cells but not from non adherent cells. These data suggest an important new function for the macrophage: aggregation of platelets and release of their vasoactive amines and others mediators of inflammation.
D000818:Animals; D000001:Calcimycin / Q000494:pharmacology; D005260:Female; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010715:Phosphatidylglycerols / Q000378:metabolism* / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects*; D051381:Rats
D010715:Phosphatidylglycerols; D000001:Calcimycin
Le facteur d'activation des plaquettes originaire des macrophages.