Vertebral end-plate depression: report of two patients without hemoglobinopathy.
Center vertebral end-plate depression was originally reported to be pathognomonic for sickle cell disease. Two patients without hemoglobinopathy were found to have this deformity. One patient has congenital hereditary spherocytosis; the other has no blood dyscrasia but is osteopenic. Therefore, although this deformity is usually due to sickle cell disease, it is not pathognomonic.
D005260:Female; D006453:Hemoglobinopathies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011859:Radiography; D013103:Spherocytosis, Hereditary / Q000473:pathology; D013122:Spinal Diseases / Q000000981:diagnostic imaging; D013904:Thoracic Vertebrae / Q000000981:diagnostic imaging*