Influence of dopamine and thyrotropin releasing hormone on the volume of nuclei of prolactin cells in rat adenohypophysis in vitro.
The effect of dopamine and TRH on the volume of prolactin cells nuclei in the rat anterior pituitary cultured in vitro has been investigated. A significant increase of volume of prolactin cells nuclei exposed to TRH has been shown. Dopamine had no significant influence on the volume of the nuclei of prolactin cells. The prolactin cells exposed to dopamine showed clearly an increased granulation. The obtained results suggest that dopamine exerts a stronger inhibiting effect on the release of prolactin than on its synthesis.
D000818:Animals; D002467:Cell Nucleus / Q000502:physiology*; D002478:Cells, Cultured; D004298:Dopamine / Q000494:pharmacology*; D005260:Female; D006651:Histocytochemistry; D010903:Pituitary Gland, Anterior / Q000187:drug effects / Q000502:physiology*; D011388:Prolactin / Q000378:metabolism*; D051381:Rats; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*
D013973:Thyrotropin-Releasing Hormone; D011388:Prolactin; D004298:Dopamine