title: [Efficacy of mebendazole in sheep experimentally invaded with larvae of Haemonchus contortus and Trichostrongylus colubriformis in relation to the results of clinical examination].
abstract: A group of six lambs at the age of two months and of the average weight of 13 kg were invaded with the larvae Haemonchus contortus and Trichostrongylus colubriformis; the course of invasion was compared with that in a group of four control lambs. In regular ten-day intervals, some hematological indices, proteinemia. SGOT and SGPT activities, glucose level, sodium and potassium were studied in blood samples; at the same time egg elimination was observed in excrement samples. The invasion intensity was checked by helminthological dissection of an experimentally invaded lamb 35th day p.i.; 576 H. contortus adults and 398 T. colubriformis adults were determined. Egg number recalculated per 1 g excrements (E.P.G.) amounted to 3072. At that stage, both groups were administered mebendazole at a dose of 10 mg active substance per 1 kg live weight on three successive days. The efficacy of the treatment (IE) was 97.01 to 98.05%. According to the clinical examination the hematocrit level dropped statistically significantly on the ninth day p.i., the other indices under study showed no changes. The drug administration increased temporarily the erythrocyte count and decreased MCV and MCH. Although mebendazole mainly inhibited glucose metabolism in the nematodes, the drug administration did not influence the glucose level of the host's blood serum.
mesh_terms: D000818:Animals; D001562:Benzimidazoles / Q000627:therapeutic use*; D004195:Disease Models, Animal; D006188:Haemonchiasis / Q000097:blood / Q000662:veterinary*; D008463:Mebendazole / Q000494:pharmacology / Q000627:therapeutic use*; D012756:Sheep; D012757:Sheep Diseases / Q000097:blood / Q000188:drug therapy*; D000637:Transaminases / Q000097:blood; D014252:Trichostrongyloidiasis / Q000097:blood / Q000662:veterinary*
chemical_list: D001562:Benzimidazoles; D008463:Mebendazole; D000637:Transaminases
vernacular_title: Ucinnost mebendazolu u ovcí experimentálnĕ invadovaných larvami Haemonchus contortus a Trichostrongylus colubriformis ve vztahu k vysledkúm klinického vysetŕení.