3-hydrazinopyridazine derivatives as inhibitors of the copper containing amine oxidases.
A series of 3-hydrazine derivatives with antihypertensive properties were studied as inhibitors of the copper containing amine oxidases. All the compounds with a free hydrazino group were found to be strong-non-competitive inhibitors. Some of them had an inhibitory activity of the same order as that of hydralazine.
D006631:Amine Oxidase (Copper-Containing) / Q000037:antagonists & inhibitors; D000818:Animals; D000959:Antihypertensive Agents; D001595:Benzylamine Oxidase / Q000037:antagonists & inhibitors; D003300:Copper / Q000037:antagonists & inhibitors; D005260:Female; D006801:Humans; D007202:Indicators and Reagents; D008930:Mitochondria, Liver / Q000201:enzymology; D008996:Monoamine Oxidase Inhibitors; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000037:antagonists & inhibitors*; D011247:Pregnancy; D011724:Pyridazines / Q000494:pharmacology*; D051381:Rats; D013552:Swine
D000959:Antihypertensive Agents; D007202:Indicators and Reagents; D008996:Monoamine Oxidase Inhibitors; D011724:Pyridazines; D003300:Copper; D001595:Benzylamine Oxidase; D006631:Amine Oxidase (Copper-Containing); D000587:Oxidoreductases Acting on CH-NH Group Donors