The use of IgM anti-D coated cells in the deliberate immunisation of Rh-negative male volunteers.
Attempts to produce anti-D in rhesus-negative men using reconstituted frozen rhesus-positive cells were unsuccessful. The use of cells coated with IgM anti-D for immunisation stimulates anti-D production, and a comparison between two groups, one having cells coated with IgM anti-D, and the other having identical cells without coating suggests that there is an enhancement of the immune response when IgM-coated cells are used.
D000917:Antibody Formation; D001793:Blood Preservation; D004912:Erythrocytes / Q000276:immunology; D006801:Humans; D007114:Immunization; D007117:Immunization, Secondary; D007075:Immunoglobulin M; D008297:Male; D010206:Papain; D012204:Rh-Hr Blood-Group System
D007075:Immunoglobulin M; D012204:Rh-Hr Blood-Group System; D010206:Papain