title: [N-Acetyl-beta-hexosaminidases. Present knowledge regarding chemical characterization and genetic relationships (author's transl)].
abstract: In recent years considerable attempts have been directed towards the chemical characterization of lysosomal hexosaminidases. Hexosaminidase A had been shown to be a heterotetramer: alpha2 beta2 and hexosaminidase B a homotetramer: beta4. Studies of GM2 gangliosidosis supported this theory, in fact alpha and beta chains require genes on different chromosomes.
mesh_terms: D002554:Cerebrosides / Q000378:metabolism; D055598:Chemical Phenomena; D002621:Chemistry; D005732:Gangliosides / Q000378:metabolism; D005733:Gangliosidoses / Q000201:enzymology; D006596:Hexosaminidases / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008247:Lysosomes / Q000201:enzymology*; D011487:Protein Conformation
chemical_list: D002554:Cerebrosides; D005732:Gangliosides; D006596:Hexosaminidases
vernacular_title: Les N-acétyl-beta-hexosaminidases. Données actuelles de leur étude et corrélations pathologiques.