The effects of administrations of HCl, NH4Cl and NH4HCO3 on the excretion of urea and ammonium in man.
In man, HCl acidosis reduces blood and urinary urea with a concomitant rise in ammonium (NH4+) excretion. Significantly less urea is excreted following NH4Cl administration than following equimolar ingestion of NH4 HCO3. The results of these alterations in nitrogen excretion are interpreted in terms of bicarbonate utilization and production.
D000328:Adult; D000643:Ammonium Chloride / Q000494:pharmacology*; D001639:Bicarbonates / Q000494:pharmacology*; D006801:Humans; D006851:Hydrochloric Acid / Q000494:pharmacology*; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology / Q000652:urine*; D014508:Urea / Q000378:metabolism*
D001639:Bicarbonates; D000644:Quaternary Ammonium Compounds; D000643:Ammonium Chloride; D014508:Urea; D006851:Hydrochloric Acid