Mutagenicity of four hair dyes in Drosophila melanogaster.
The hair dye constituents p-phenylenediamine, 2,4-diaminoanisole sulfate, 2,4-diaminotoluene and 4-nitro-0-phenylenediamine were tested for mutagenicity in Drosophila melanogaster. The compounds were given orally to adult males. The induction of sex-linked recessive lethal mutation was used as a measure of mutagenicity. All four of the dyes tested were mutagenic with a peak mutagenic activity in metabolically active germ cells (spermatids and spermatocytes).
D000818:Animals; D000840:Anisoles / Q000633:toxicity; D003358:Cosmetics / Q000633:toxicity*; D004331:Drosophila melanogaster / Q000187:drug effects*; D005260:Female; D005808:Genes, Recessive; D008297:Male; D009153:Mutagens; D010655:Phenylenediamines / Q000633:toxicity*; D013087:Spermatids / Q000187:drug effects; D013090:Spermatocytes / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects; D014050:Toluene / Q000031:analogs & derivatives / Q000633:toxicity
D000840:Anisoles; D003358:Cosmetics; D009153:Mutagens; D010655:Phenylenediamines; D014050:Toluene; C007294:4-methoxy-3-phenylenediamine; C010914:2,4-diaminotoluene