[Biosynthesis and cellular localization of betal-g-globulin in the human placenta].
Pregnancy-specific beta1-globulin (beta1-GP) described by Tatarinov and Masyukevich, 1970) was shown by means of immunodiffusion in agar gel to be similar to specific pregnancy beta1-glycoprotein of Bohn (1971) as well as to pregnancy associated plasma protein-C of Lin et al (1974). It was found that in immature placenta (6-12 weeks of pregnancy) incorporation of 14S-amino acids into beta1-GP took place. Studies on immunofluorescence showed that beta1-GP was localized in cytoplasma of trophoblastic cells of placenta chorion. Beta1-GP production apparently begins in Langhans cells and proceeds in syncytiotrophoblastic cells, but at lower activity and secretory scale.
D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D005779:Immunodiffusion; D007122:Immunoelectrophoresis; D009928:Organ Specificity; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D011863:Radioimmunoassay; D012712:Serum Globulins / Q000032:analysis / Q000096:biosynthesis*
D012712:Serum Globulins
Izuchenie biosinteza i kletochnoĭ lokalizatsii betal-g-globulina v platsente cheloveka