Radiation from tritiated thymidine perturbs the cell cycle progression of stimulated lymphocytes.
Tritiated thymidine was found to affect the cell cycle progression of phytohemagglutinin-stimulated human lymphocytes. By means of flow cytometry a statistically significant increase in the G2 and M phases of the cell cycle was observed in cultures with low concentrations of tritiated thymidine added 18 hours before the cultures were harvested.
D002453:Cell Cycle / Q000187:drug effects / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008213:Lymphocyte Activation / Q000528:radiation effects*; D008214:Lymphocytes / Q000528:radiation effects*; D008938:Mitosis / Q000528:radiation effects; D010835:Phytohemagglutinins / Q000494:pharmacology; D013936:Thymidine / Q000494:pharmacology; D013997:Time Factors; D014316:Tritium
D010835:Phytohemagglutinins; D014316:Tritium; D013936:Thymidine