[Respective effects on locomotor activity of injections of 5, 7-DHT in median raphe nucleus and of 6-OHDA in the mesolimbic dopaminergic group area in the rat].
This experiment was performed in order to demonstrate that the locomotor hyperactivity provoked by a radiofrequency lesion of the ventral mesencephalic tegmentum-A10 DA group area was not due to a 5-HT fiber damage. Four groups of Rats were used. First groups II and IV received a 5, 7-DHT injection in the median raphe; groups I and III received the vehicle. Locomotor activity was measured in a circular corridor 10 and 30 days; no hyperactivity was obtained. Then the same groups received a 6-OHDA injection, bilaterally in the A 10 area (groups III and IV) or the vehicle (groups I and II); the activity was measured 10 days later: significant hyperactivity was obtained with groups III and IV, without statistical differences between these two groups. In conclusion (i) 5-HT neurons are not directly involved in the VMT-hyperactivity, (ii) the DA A 10 neurons seem to be a critical anatomical target for this symptom.
D000818:Animals; D006801:Humans; D006892:Hydroxydopamines / Q000494:pharmacology*; D006948:Hyperkinesis; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D011846:Radio Waves; D051381:Rats; D011954:Receptors, Dopamine; D012154:Reticular Formation / Q000187:drug effects / Q000502:physiology; D013681:Tegmentum Mesencephali / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D014363:Tryptamines / Q000494:pharmacology*
D006892:Hydroxydopamines; D011954:Receptors, Dopamine; D014363:Tryptamines
Effets respectifs sur l'activité locomotrice de l'injection de 5. 7-DHT dans le noyau raphé médian, et de 6-OHDA dans l'aire du groupe dopaminergique mésolimbique du Rat