title: Effect of bovine pancreatic polypeptide on basal pancreatic and biliary outputs in man.
abstract: Basal pancreatic and biliary outputs were examined in seven healthy volunteers during intravenous infusion of bovine pancreatic polypeptide (BPP) at a mean dose of 320 pmol/kg/hr. BPP significantly (P less than 0.02) inhibited outputs of trypsin and bilirubin, without affecting bicarbonate. These studies suggest the possibility that pancreatic polypeptide may have a role in the regulation of biliary and pancreatic enzyme secretion in man.
mesh_terms: D000328:Adult; D001639:Bicarbonates / Q000378:metabolism; D001646:Bile / Q000032:analysis / Q000378:metabolism*; D001663:Bilirubin / Q000378:metabolism*; D005704:Gallbladder / Q000187:drug effects; D006801:Humans; D007263:Infusions, Parenteral; D008875:Middle Aged; D010179:Pancreas / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D010189:Pancreatic Juice / Q000201:enzymology / Q000378:metabolism*; D010191:Pancreatic Polypeptide / Q000008:administration & dosage / Q000494:pharmacology*; D012636:Secretory Rate / Q000187:drug effects; D014357:Trypsin / Q000378:metabolism*
chemical_list: D001639:Bicarbonates; D010191:Pancreatic Polypeptide; D014357:Trypsin; D001663:Bilirubin