Activation of complement by radiographic contrast media: generation of chemotactic and anaphylatoxin activities.
Iodinated radiographic contrast media such as methylglucamine diatrizoate and sodium ioglycamate activate serum complement in vitro. This was shown by a dose-, time-, and temperature-dependent decrease of total hemolytic complement activity in normal human serum, consumption of C4 and C6 activity, conversion of C3 to C3b, and generation of C5-derived chemotactic and smooth muscle contracting activity. Complement activation was achieved even in sera depleted of immunoglobulin and properdin, which may indicate that contrast media induce complement activation by mechanisms different from the classical or alternative pathway.
D000706:Anaphylatoxins / Q000096:biosynthesis*; D002633:Chemotaxis / Q000187:drug effects*; D003176:Complement C3; D003181:Complement C4; D003183:Complement C6; D003165:Complement System Proteins / Q000378:metabolism; D003287:Contrast Media / Q000494:pharmacology*; D003974:Diatrizoate Meglumine / Q000494:pharmacology; D004492:Edetic Acid / Q000494:pharmacology; D004533:Egtazic Acid / Q000494:pharmacology; D006801:Humans; D007471:Ioglycamic Acid / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D010452:Peptide Biosynthesis
D000706:Anaphylatoxins; D003176:Complement C3; D003181:Complement C4; D003183:Complement C6; D003287:Contrast Media; D003974:Diatrizoate Meglumine; D004533:Egtazic Acid; D003165:Complement System Proteins; D004492:Edetic Acid; D007471:Ioglycamic Acid