Potentiation of PG effects on the intraocular muscles of the cat by inhibition of PG synthesis.
Various PG synthesis inhibitors potentiate the effects of PGE1, E2 and F2 alpha on isolated sphincter, dilator and ciliary muscles of the cat when added to the bath or injected intravenously. Potentiation depends on dose and type of PG synthetase inhibitor. A hypothesis for the potentiation is discussed.
D000818:Animals; D002415:Cats; D002924:Ciliary Body / Q000187:drug effects*; D016861:Cyclooxygenase Inhibitors; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D005480:Flurbiprofen / Q000494:pharmacology; D007052:Ibuprofen / Q000494:pharmacology; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D007498:Iris / Q000187:drug effects*; D006899:Mixed Function Oxygenases / Q000037:antagonists & inhibitors*; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D011453:Prostaglandins / Q000494:pharmacology*; D011458:Prostaglandins E / Q000494:pharmacology; D011460:Prostaglandins F / Q000494:pharmacology
D016861:Cyclooxygenase Inhibitors; D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; D005480:Flurbiprofen; D006899:Mixed Function Oxygenases; D007052:Ibuprofen; D007213:Indomethacin