title: The regulation of stable RNA synthesis in the blue-green alga Anacystis nidulans: effect of leucine deprivation and 5-methyltryptophan inhibition.
abstract: The expression of phenomena associated with the bacterial function controlling RNA synthesis was studied in leucine-deprived or 5-methyltryptophan-treated cultures of Anacystis nidulans. Both procedures retarded cell growth, RNA and protein accumulation, elicited the accumulation of high intracellular concentrations of guanosine 5'-diphosphate-3'-diphosphate(ppGpp)and guanosine5'-triphosphate-3'-diphosphate(pppGpp),and promoted a regime of non-coordinate synthesis of stable and messenger RNA. The rate of polymerization of nascent RNA chains did not appear to be retarded in the growth-limited cultures.
mesh_terms: D000458:Cyanobacteria / Q000378:metabolism*; D007930:Leucine / Q000378:metabolism*; D010940:Plant Proteins / Q000096:biosynthesis; D012313:RNA / Q000096:biosynthesis*; D012333:RNA, Messenger / Q000378:metabolism; D012343:RNA, Transfer / Q000378:metabolism; D014364:Tryptophan / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: D010940:Plant Proteins; D012333:RNA, Messenger; D012313:RNA; D014364:Tryptophan; D012343:RNA, Transfer; D007930:Leucine