The role of histamine in implantation in the rabbit.
When disodium cromoglycate, an inhibitor of histamine release, was instilled into the uterine lumen on Days 5 or 6 of pregnancy, the number of blastocysts implanting was significantly (P less than 0.002) reduced. Simultaneous instillation of histamine and disodium cromoglycate prevented the effect.
D000818:Animals; D004205:Cromolyn Sodium / Q000494:pharmacology; D003864:Depression, Chemical; D010064:Embryo Implantation / Q000187:drug effects; D005260:Female; D006632:Histamine / Q000494:pharmacology / Q000502:physiology*; D011247:Pregnancy; D011817:Rabbits / Q000502:physiology*
D006632:Histamine; D004205:Cromolyn Sodium