Effects of aresenite and oxamate on the in vitro functional activity of estrogen-dominated rate uterine horns.
Arsenite but not oxamate produce in vitro a distinct depression of estrogen-dominated uterine motility, both in the absence of substrate as well as in the presence of exogenous glucose or lactate. The addition of oxamate to preparations suspended in a medium with lactate as the sole external substrate ameliorates the depression of uterine motility elicited by arsenic.
D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D001151:Arsenic / Q000494:pharmacology*; D018053:Arsenites; D002952:Citric Acid Cycle / Q000187:drug effects; D003864:Depression, Chemical; D004967:Estrogens / Q000494:pharmacology; D005260:Female; D005947:Glucose / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000037:antagonists & inhibitors; D007773:Lactates / Q000378:metabolism; D010072:Oxamic Acid / Q000494:pharmacology*; D010121:Oxytocin / Q000494:pharmacology; D051381:Rats; D014590:Uterine Contraction / Q000187:drug effects*; D014599:Uterus / Q000378:metabolism
D000596:Amino Acids; D018053:Arsenites; D004967:Estrogens; D007773:Lactates; D010121:Oxytocin; D007770:L-Lactate Dehydrogenase; D005947:Glucose; C015001:arsenite; D001151:Arsenic; D010072:Oxamic Acid