Synthesis and biological activity of some derivatives of thiochroman-4-one and tetrahydrothiapyran-4-one.
A small series of pyrazoles and isoxazoles derived from thiochroman-4-one has been synthesized and characterized. The compounds were examined for their in vitro inhibitory activity against Bacillus subtilis and Pseudomonas fluorescens. Among the tested compounds the pyrazole derivative from thiochroman-4-one was found to be the most effective inhibitor of growth of B. subtilis. Extensive H NMR analysis was recorded for all compounds.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D001412:Bacillus subtilis / Q000187:drug effects; D001578:Benzopyrans / Q000138:chemical synthesis*; D002478:Cells, Cultured; D002839:Chromans / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D003609:Dactinomycin / Q000627:therapeutic use; D004357:Drug Synergism; D006571:Heterocyclic Compounds / Q000138:chemical synthesis*; D007939:Leukemia L1210 / Q000188:drug therapy; D008297:Male; D051379:Mice; D008937:Mitomycins / Q000627:therapeutic use; D011551:Pseudomonas fluorescens / Q000187:drug effects; D011714:Pyrans / Q000494:pharmacology / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D001578:Benzopyrans; D002839:Chromans; D006571:Heterocyclic Compounds; D008937:Mitomycins; D011714:Pyrans; D003609:Dactinomycin