Sister chromatid exchanges and aging. III. The effect of donor age on mutagen-induced sister chromatid exchange in human diploid fibroblasts.
Although baseline levels of SCE appear to be similar in metaphase cells derived from young and old human skin fibroblast cultures, a significant decline in both MMC- and AAAF-induced sister chromatid exchanges was observed in the older cell populations. Considerable variation exists in the levels of MMC-induced SCE between individual cell cultures. However, parallel examination of several cell strains from young and old donors confirmed the decrease in mutagen-induced SCE frequencies in older cell populations.
D000099:Acetoxyacetylaminofluorene / Q000494:pharmacology; D000328:Adult; D000368:Aged; D000375:Aging; D001973:Bromodeoxyuridine; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D002877:Chromosomes, Human / Q000187:drug effects; D003434:Crossing Over, Genetic; D006801:Humans; D008937:Mitomycins / Q000494:pharmacology; D009153:Mutagens / Q000494:pharmacology*; D012867:Skin / Q000166:cytology / Q000648:ultrastructure
D008937:Mitomycins; D009153:Mutagens; D000099:Acetoxyacetylaminofluorene; D001973:Bromodeoxyuridine