[Study of the antiviral activity of a poly I : poly-C complex with poly-L-lysine in monkeys].
Antiviral activity of poly-I-poly-C complex with poly-L-lysine was studied on macaco rhesus. The complex bifilamentous polyribonucleotide induced active production of serum interferon and provided pronounced protection of the monkeys infected intracutaneously with the variolovaccine virus (10 LD50 for the monkeys in intracutaneous infection). The effectiveness of the protective effect depended on the scheme and route of the drug administration. The highest prophylactic and therapeutic effect was provided by local administration of the complex in a dose of I mg per I kg of the body weight, the incubation period being increased 2--3 times and the period of the skin affections being decreased approximately 2 times. The results of the studies on the effect of poly-I-poly-C complex with poly-L-lysine were evident of definite prophylactic activity of the drug against experimental vernal encephalitis in the monkeys. The animals not treated with the inductor died on the 16th or 17th day after infection because of the paralysis of the trunc and extremities muscles. The clinical evidences of the disease in the animals treated with the drug were not uniform: from complete health to death.
D000818:Animals; D000998:Antiviral Agents; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D004675:Encephalitis, Tick-Borne / Q000188:drug therapy; D000882:Haplorhini; D007369:Interferon Inducers; D008251:Macaca; D010455:Peptides / Q000627:therapeutic use*; D011070:Poly I-C / Q000627:therapeutic use*; D011107:Polylysine / Q000627:therapeutic use*; D013997:Time Factors; D014615:Vaccinia / Q000188:drug therapy
D000998:Antiviral Agents; D004338:Drug Combinations; D007369:Interferon Inducers; D010455:Peptides; D011107:Polylysine; D011070:Poly I-C
Izuchenie protivovirusnoĭ aktivnosti kompleksa poli-I : poli-Ts s poli-L-lizinom u obez'ian