The effect of a proteolytic enzyem mixture (Orenzyme-Forte) on experimentally induced pulpitis.
A proteolytic enzyme mixture, Orenzyme-Forte, containing trypsin, chymotrypsin, and ribonuclease was used to treat experimentally induced pulpitis in the teeth of three monkeys. Assessment by means of the criteria of Stanley showed that the enzyme mixture induced better healing than a zinc oxide--eugenol dressing. When the two were used simultaneously, a synergistic effect was seen. We suggest that this enzyme mixture may be useful in clinical practice in the treatment of pulpitis.
D000818:Animals; D002521:Cercopithecus; D002918:Chymotrypsin / Q000627:therapeutic use*; D004338:Drug Combinations; D000882:Haplorhini; D011671:Pulpitis / Q000188:drug therapy* / Q000473:pathology; D012260:Ribonucleases / Q000627:therapeutic use*; D012390:Root Canal Therapy; D014357:Trypsin / Q000627:therapeutic use*; D015035:Zinc Oxide-Eugenol Cement
D004338:Drug Combinations; D015035:Zinc Oxide-Eugenol Cement; D012260:Ribonucleases; D002918:Chymotrypsin; D014357:Trypsin