Diabetogenic action of human growth hormone. Synthesis and activity of C-terminal fragments.
Three peptides corresponding to the C-terminal region of human growth hormone have been synthesized by the solid-phase method: HGH-(177--191), HGH-(178--191) and HGH-(179--191). The diabetogenic activities of these synthetic peptides are reported. The data indicate that extension of HGH-(179--191) at its NH2-terminus is required for in vivo activity. The reduced and S-carbamidomethylated form of HGH-(177--191) was also active, indicating that the disulphide bond is possibly not a prerequisite for biological activity.
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D005951:Glucose Tolerance Test; D013006:Growth Hormone / Q000138:chemical synthesis* / Q000494:pharmacology; D010084:Oxidation-Reduction; D010446:Peptide Fragments; D051381:Rats
D000596:Amino Acids; D001786:Blood Glucose; D010446:Peptide Fragments; D013006:Growth Hormone