Ultrastructure of experimentally produced subcutaneous haematomas in the rabbit.
Haematomas were produced in rabbits by subcutaneous injection of autologous blood. Clotting and marked lysis of erythrocytes was noted in these haematomas, but there was no evidence of fragmentation of erythrocytes prior to or after ingestion by macrophages as has been reported in other sites such as the peritoneal cavity and the joint cavity. The phagocytosis of intact erythrocytes, lysed erythrocytes and haemoglobin led to the formation of three main types of lysosomal bodies; (1) myelinosomes containing whorled osmiophilic membranes, (2) siderosomes containing haemosiderin, and (3) myelinosiderosomes containing a mixture of osmiophilic membranes and haemosiderin.
D000818:Animals; D003238:Connective Tissue / Q000473:pathology; D004195:Disease Models, Animal; D004912:Erythrocytes / Q000648:ultrastructure; D006406:Hematoma / Q000473:pathology*; D008247:Lysosomes / Q000648:ultrastructure; D008264:Macrophages / Q000502:physiology / Q000648:ultrastructure; D010587:Phagocytosis; D011817:Rabbits; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000473:pathology*