Whole antilymphocyte serum: a potent safe immunosuppressive agent for intravenous use in man.
Fifty-one renal and marrow graft recipients have been treated with whole, absorbed rabbit anti-human-lymphocyte serum. Such sera are potent nontoxic immunosuppressive agents. Preexisting sensitivity can be erased, and early rejection episodes are essentially eliminated. Prolonged treatment is necessary and safe, and it ensures a sustained depression in circulating T cells. Adaptation between kidney graft and host then occurs, so that the combination of prednisone and Imuran alone can sustain graft viability.
D000818:Animals; D000961:Antilymphocyte Serum / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006085:Graft Survival; D000882:Haplorhini; D006801:Humans; D007111:Immunity, Cellular; D007166:Immunosuppressive Agents; D007275:Injections, Intravenous; D008253:Macaca mulatta; D011817:Rabbits; D016038:Skin Transplantation; D013601:T-Lymphocytes / Q000276:immunology; D014184:Transplantation, Homologous
D000961:Antilymphocyte Serum; D007166:Immunosuppressive Agents