title: Prolactin deficiency in pseudohypoparathyroidism.
abstract: Because thyrotropin deficiency may occur in pseudohypoparathyroidism, we studied pituitary function in two families with this condition. Six of eight patients had impaired pituitary prolactin secretion after administration of thyrotropin-releasing hormone and chlorpromazine, with preservation of other anterior pituitary functions. Peak serum prolactin levels after thyrotropin-releasing hormone and chlorpromazine in the prolactin-deficient patients were significantly lower than normal. Administration of diethylstilbestrol for five days, which normally enhances prolactin responses to thyrotropin-releasing hormone, had no effect on prolactin secretion in these patients. Although antilactotroph antibodies were not demonstrable, hypothyroidism or decreased thyroid reserve in four and antithyroid and antiparietal-cell antibodies in several family members suggest that an associated autoimmune process may be responsible for the prolactin deficiency.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D002746:Chlorpromazine; D004054:Diethylstilbestrol / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010901:Pituitary Function Tests; D011388:Prolactin / Q000172:deficiency* / Q000378:metabolism; D011547:Pseudohypoparathyroidism / Q000175:diagnosis / Q000276:immunology / Q000503:physiopathology*; D011972:Receptor, Insulin; D012636:Secretory Rate / Q000187:drug effects; D013954:Thyroglobulin / Q000276:immunology; D013960:Thyroid Function Tests; D013973:Thyrotropin-Releasing Hormone
chemical_list: D001323:Autoantibodies; D013973:Thyrotropin-Releasing Hormone; D004054:Diethylstilbestrol; D011388:Prolactin; D013954:Thyroglobulin; D011972:Receptor, Insulin; D002746:Chlorpromazine