Antischistosomal effects of 5-(2,4,5-trichlorophenyl)hydantoin and related compounds.
5-(2,4,5-Trichlorophenyl)hydantoin and several analogues effected an 80-90% reduction of live schistosomes in infected mice at doses ranging from 265 to 329 mg/kg per day when administered orally in the diet for 14 days. The sodium salt of 5-(2,4,5-trichlorophenyl)hydantoin, when given by gavage to rhesus monkeys infected with Schistosoma mansoni at 200 mg/kg/day for 5 or 10 days, removed all but a few live worms with no evidence of intolerance.
D000818:Animals; D000882:Haplorhini; D006827:Hydantoins / Q000138:chemical synthesis* / Q000494:pharmacology; D008253:Macaca mulatta; D051379:Mice; D012550:Schistosoma mansoni; D012552:Schistosomiasis / Q000503:physiopathology; D012556:Schistosomicides / Q000138:chemical synthesis*; D013329:Structure-Activity Relationship
D006827:Hydantoins; D012556:Schistosomicides