title: [Clinical and biological manifestations following the interruption of prolonged treatment with clonidine].
abstract: In 7 out of 14 patients there were marked subjective symptoms following the interruption of prolonged treatment with clonidine. A significant increase in blood pressure, systolic and diastolic, heart rate and urinary catecholamine excretion was seen in the majority of cases. The clinical and biological manifestations would appear to reflect a phenomenon of derepression of sympathetic activity: the increase in urinary catecholamines is the biological result. The findings are of practical importance since they indicate that the interruption of anti-hypertensive therapy with clonidine must be under taken with caution, i.e. progressively.
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D003000:Clonidine / Q000008:administration & dosage* / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000652:urine; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000139:chemically induced; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000652:urine; D012083:Renin / Q000097:blood; D013610:Tachycardia / Q000139:chemically induced
chemical_list: D012083:Renin; D003000:Clonidine; D009638:Norepinephrine; D004837:Epinephrine
vernacular_title: Manifestations cliniques et biologiques  l'arrêt d'un traitement prolongé par la clonidine