Serum mineral changes in alloxan diabetes before and after treatment with some hypoglycemic drugs.
In alloxan diabetes, serum zinc, copper, iron and magnesium were significantly higher than in normal rats, while the level of serum calcium, sodium, and potassium was lower than normal. Treatment with daonil or insulin led to a normalization, as expected of the level of serum glucose and most of the other elements, except for iron and potassium. When lycanol was used for treatment, the level of all elements returned to the normal except for blood glucose, zinc and potassium.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002118:Calcium / Q000097:blood; D003300:Copper / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000188:drug therapy; D005905:Glyburide / Q000627:therapeutic use; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000627:therapeutic use; D007501:Iron / Q000097:blood; D008297:Male; D008903:Minerals / Q000097:blood*; D011188:Potassium / Q000097:blood; D051381:Rats; D012964:Sodium / Q000097:blood; D015032:Zinc / Q000097:blood
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D008903:Minerals; D003300:Copper; D012964:Sodium; D007501:Iron; D015032:Zinc; D011188:Potassium; D005905:Glyburide; D002118:Calcium