[HLA groups in the infantile psychoses during development, and hypothesis for an enzyme defect].
The HLA typing (loci A and B) of a series of fifteen psychotic children has shown an increase of the frequency of both HLA-A9 and B5 antigens. These preliminary data and previous biochemical findings in psychotic patients lead the authors to postulate the hypothesis of a qualitative or quantitative anomaly of the superoxide dismutase (SOD-2), the gene of which is situated on the same chromosome (sixth) as the HLA complex.
D002657:Child Development; D002665:Child Psychiatry; D002675:Child, Preschool; D002900:Chromosomes, Human, 1-3; D008040:Genetic Linkage; D006680:HLA Antigens / Q000032:analysis*; D006649:Histocompatibility Antigens / Q000032:analysis*; D006801:Humans; D007223:Infant; D011618:Psychotic Disorders / Q000201:enzymology / Q000276:immunology*; D013482:Superoxide Dismutase
D006680:HLA Antigens; D006649:Histocompatibility Antigens; D013482:Superoxide Dismutase
Etude des groupes HLA dans les psychoses infantiles de développement et hypothèse d'une enzymopathie.