Antimicrobial susceptibility of gentamicin-resistant Pseudomonas aeruginosa.
The susceptibility of 41 strains of gentamicin-resistant Pseudomonas aeruginosa to tobramycin, sisomicin, netilmicin, amikacin, and carbenicillin was determined. Amikacin and carbenicillin exhibited the greatest activity against these strains and especially against those with a high level of resistance to gentamicin. Netilmicin exhibited little activity, whereas tobramycin and sisomicin were active against approximately two-thirds of the strains. Cross-resistance to tobramycin, sisomicin, and netilmicin was frequent.
D000583:Amikacin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002228:Carbenicillin / Q000494:pharmacology; D005839:Gentamicins / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D011552:Pseudomonas Infections / Q000188:drug therapy*; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D012853:Sisomicin / Q000031:analogs & derivatives / Q000494:pharmacology; D014031:Tobramycin / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D000583:Amikacin; D002228:Carbenicillin; D014031:Tobramycin; D012853:Sisomicin