Bacterial metabolism of corticoids with particular reference to the 21-dehydroxylation.
Clostridium paraputrificum, an obligate anaerobe recovered from human feces, reduces the alpha,beta-unsaturated carbonyl of deoxycorticosterone, corticosterone, cortisone, and cortisol. The same steroids are 21-dehydroxylated by Culture 116, recently isolated from human feces, and by a closely related organism, Eubacterium lentum. The 21-dehydroxylase has no effect on hydroxyl groups at carbon atoms 11 and 17.
D000305:Adrenal Cortex Hormones / Q000378:metabolism*; D001419:Bacteria / Q000378:metabolism; D003013:Clostridium / Q000378:metabolism*; D005051:Eubacterium / Q000378:metabolism*; D005243:Feces / Q000382:microbiology; D006801:Humans; D013058:Mass Spectrometry; D013250:Steroid Hydroxylases / Q000378:metabolism*
D000305:Adrenal Cortex Hormones; D013250:Steroid Hydroxylases