title: Stability of antimicrobials in Schaedler's anaerobic and brain heart infusion broths stored at --20 degrees C.
abstract: Penicillin-like drugs are found to be unstable in SCHAEDLER'S broth in forzen storage (--20 degrees C). Chloramphenicol, clindamycin and tetracycline remained at original potency to 45 days. No detectable antimicrobial decay was found in two formulations of supplemented BHI broth. Antimicrobial potency was measured by quality control organism endpoints, bioassays and MIC changes in use at four clinical microbiology laboratories.
mesh_terms: D000693:Anaerobiosis; D000900:Anti-Bacterial Agents / Q000032:analysis; D001439:Bacteroides / Q000378:metabolism; D003013:Clostridium / Q000378:metabolism; D003470:Culture Media / Q000032:analysis; D004355:Drug Stability; D013293:Enterococcus faecalis / Q000378:metabolism; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D003470:Culture Media