Circulating platelet aggregates and thrombocytopenia induced by intravenous infusions of arachidonic and lauric acids in guinea pigs.
Slow intravenous infusion of Na laurate (NaL) into guinea pigs caused a rapid appearance of platelet aggregates in the arterial blood and a precipitous fall in platelet counts. During the infusion of Na arachidonate (NaA) thrombocytopenia developed slowly, and few and smaller platelet aggregates appeared in the arterial blood. Considerably more guinea pigs died during or after the NaA infusion than after administration of NaL. The possibility that arachidonic acid and other long-chain fatty acids may play a role in the development of thrombosis and thromboembolism is discussed.
D000818:Animals; D001095:Arachidonic Acids / Q000008:administration & dosage / Q000494:pharmacology*; D001772:Blood Cell Count; D006168:Guinea Pigs; D007263:Infusions, Parenteral; D007850:Lauric Acids / Q000008:administration & dosage / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D013921:Thrombocytopenia / Q000139:chemically induced*
D001095:Arachidonic Acids; D007850:Lauric Acids