Mass spectrometric peptide sequencing: cyclochlorotine.
A potent toxin isolated from Penicillium islandicum Sopp was found to have the composition C24H31N5O7Cl2. Mass spectrometric investigation of a partial acid hydrolyzate showed that it has the structure of cyclochlorotine. The mass spectral characteristics of polyamino alcohol-related derivatives of peptides containing beta-phenylalanine, alpha-amino butyric acid and dichloroproline were determined in the course of this work.
D000595:Amino Acid Sequence; D000613:Aminobutyrates / Q000032:analysis; D001427:Bacterial Toxins / Q000032:analysis; D002713:Chlorine / Q000032:analysis; D013058:Mass Spectrometry; D009183:Mycotoxins / Q000032:analysis*; D010407:Penicillium; D010456:Peptides, Cyclic / Q000032:analysis*; D010649:Phenylalanine / Q000032:analysis; D011392:Proline / Q000031:analogs & derivatives / Q000032:analysis
D000613:Aminobutyrates; D001427:Bacterial Toxins; D009183:Mycotoxins; D010456:Peptides, Cyclic; D010649:Phenylalanine; D002713:Chlorine; D011392:Proline