[Effect of a poly I-poly C complex with poly-L-lysine on experimental tick-borne encephalitis].
The influence of the poly(I)-poly(C) complex with poly-l-lysine on the development and course of experimental tick-borne encephalitis was studied in Macaca rhesus monkeys. Prophylactic administration of the substance under study, although not preventing the disease, modified its course and facilitated recovery of the animals. Poly(I)-poly(C) and its complex with poly-l-lysine were shown to have no effect on production of infectious virus or its antigen demonstrable by the immunofluorescence procedure in HEp-2 cells chronically infected with tick-borne encephalitis virus.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D002478:Cells, Cultured; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D004675:Encephalitis, Tick-Borne / Q000188:drug therapy*; D000882:Haplorhini; D066298:In Vitro Techniques; D007369:Interferon Inducers; D007372:Interferons / Q000097:blood; D008251:Macaca; D010455:Peptides / Q000627:therapeutic use*; D011070:Poly I-C / Q000627:therapeutic use*; D011107:Polylysine / Q000627:therapeutic use*; D013997:Time Factors
D004338:Drug Combinations; D007369:Interferon Inducers; D010455:Peptides; D011107:Polylysine; D007372:Interferons; D011070:Poly I-C
Vliianie kompleksirovannogo poliI-poliTs s poli-L-lizinom na éksperimental'nyĭ kleshchevoĭ éntsefalit.