Methylxanthine-facilitated shock-induced aggression in the rat.
The methylxanthines caffeine and aminophylline, in daily doses of 100 mg/kg, facilitated shock-induced aggression in the rat. Under the limited parameters of this study, there was no induction of mouse-killing behavior or alteration of jump thresholds. Additional studies showed the optimal dose and time course for the facilitation of shock-induced aggression by caffeine to be 50 mg/kg administered i.p. 4 h prior to testing. Facilitation of a central adrenergic system may be the mechanism of action.
D000374:Aggression / Q000187:drug effects*; D000628:Aminophylline / Q000494:pharmacology*; D000818:Animals; D002110:Caffeine / Q000494:pharmacology*; D004597:Electroshock; D006801:Humans; D008297:Male; D051381:Rats; D013268:Stimulation, Chemical; D013997:Time Factors
D000628:Aminophylline; D002110:Caffeine