Successful prophylaxis against rabies in mice and Rhesus monkeys: the interferon system and vaccine.
Addition of interferon to ineffective rabies virus vaccines by the local injection of either exogenous interferon or a potent interferon inducer (a complex of polyriboinosinic-polyribocytidylic acid containing poly-L-lysine and carboxymethylcellulose) into the footpads of mice previously challenged with rabies virus dramatically reduced the mortality rate. A significant reduction in mortality rate was also noted when the interferon system was administered to rhesus monkeys, but only when treatment was given 6 hr after challenge with rabies virus. Since the monkeys were given an overwhelming challenge of virus, the treatment had to be given quickly to obtain results comparable to those in mice.
D000818:Animals; D000914:Antibodies, Viral; D002266:Carboxymethylcellulose Sodium / Q000627:therapeutic use; D000882:Haplorhini; D007372:Interferons / Q000097:blood / Q000627:therapeutic use*; D008253:Macaca mulatta; D051379:Mice; D011070:Poly I-C / Q000627:therapeutic use; D011107:Polylysine / Q000627:therapeutic use; D011818:Rabies / Q000401:mortality / Q000517:prevention & control*; D011819:Rabies Vaccines; D011820:Rabies virus / Q000276:immunology
D000914:Antibodies, Viral; D011819:Rabies Vaccines; D011107:Polylysine; D007372:Interferons; D002266:Carboxymethylcellulose Sodium; D011070:Poly I-C