title: Circulating anticoagulant against factor XI and thrombocytopenia with platelet aggregation inhibition in systemic lupus erythematosus.
abstract: In a patient with systemic lupus erythematosus, anticoagulant activity directed against factor XI was found together with thrombocytopenia. In the serum globulin fraction, antiplatelet antibodies and an activity-inhibiting platelet aggregation could also be found. A possible correlation between the inhibition of platelet aggregation and the anticoagulant activity directed against factor XI is discussed.
mesh_terms: D000328:Adult; D000906:Antibodies; D001777:Blood Coagulation; D001792:Blood Platelets / Q000276:immunology; D005172:Factor XI; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood*; D010974:Platelet Aggregation; D013921:Thrombocytopenia
chemical_list: D000906:Antibodies; D005172:Factor XI