title: Copper and inflammation.
abstract: Bonta, Sorenson and others have shown that Cu(II) derivatives are effective anti-inflammatory agents. Some chemical and pharmacological properties of Cu(I) and metallic Cu are discussed. Thio complexes of Cu(I) were prepared and shown to be useful anti-inflammatory agents in rats. Hypotheses are stated concerning the possible therapeutic value of copper in its various oxidation states.
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000266:history; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001169:Arthritis, Experimental / Q000188:drug therapy; D002621:Chemistry; D003300:Copper / Q000266:history / Q000494:pharmacology* / Q000633:toxicity; D005260:Female; D006046:Gold / Q000494:pharmacology; D006052:Gold Sodium Thiomalate / Q000138:chemical synthesis; D049690:History, Ancient; D007509:Irritants; D008297:Male; D051381:Rats; D013870:Thiomalates / Q000138:chemical synthesis
chemical_list: D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D007509:Irritants; D013870:Thiomalates; D006052:Gold Sodium Thiomalate; D006046:Gold; D003300:Copper