[Analysis of the types of chromosome aberrations in the combined action of chemical mutagens].
Types of chromosome aberrations were studied in human lymphocyte cultures in combined action of different concentrations of thiophosphamide and dipine in different proportions. The mutagens acted at the Go stage. The range of the concentrations studied was from 3.17-10(-5) M to22.19-10(-5) M. As compared with dipine, the equimolar concentrations of thiophosphamide induced more chromatid exchanges and less sister (isolocus) unions, and also a greater part of single breaks and the part of breaks in the chromatid exchanges of the total number of chromosomal breaks. Both absolute and relative frequencies of chromosome aberrations depended on the mutagens concentration. A change of the thiophosphamide and dipine proportion with a constant total number of molecules of the two mutagens at different concentration levels led to the effect, the level of which was between the effect of action of equimolar concentrations of pure mutagens. This effect depended upon the part of each mutagen in combined treatment. A conclusion was drawn on the additivity of thiophosphamide and dipine action.
D001388:Aziridines / Q000494:pharmacology; D002478:Cells, Cultured; D002842:Chromatids / Q000187:drug effects; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004347:Drug Interactions; D006801:Humans; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000187:drug effects; D009153:Mutagens / Q000494:pharmacology*; D010879:Piperazines / Q000494:pharmacology; D012996:Solutions; D013852:Thiotepa / Q000494:pharmacology
D001388:Aziridines; D004338:Drug Combinations; D009153:Mutagens; D010879:Piperazines; D012996:Solutions; D013852:Thiotepa
Analiz tipov khromosomnykh aberratsiĭ pri sovmestnom deĭstvii khimicheskikh mutagenov.