[Thyroid activity in patients with myasthenia].
In 27 patients with myasthenia thyroid function tests were done using radioassay methods. The levels of thyroxine (T4), triiodothyronine (T3), thyroxine-binding protein (BT4) and thyrotrophic hormone (TSH) were determined simultaneously in the serum. In 4 myasthenics the levels of T3 and T4 were determined after administration of exogenous TSH (Ambinon). The control group comprised 13 subjects without thyroid function disturbances. The investigations demonstrated a statistically significant decrease of T4 (at p less than 0.05) and T3 (at p less than 0.01) in myasthenia as compared with the control group. Administration of TSH raised the T3 level by 40% and that of T4 by 6%. The results obtained by the authors indicate presence of secondary hypothyroidism in myasthenia possibly due, to failure of the hypophyseo-hypothalamic system.
D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D007037:Hypothyroidism / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000503:physiopathology*; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000503:physiopathology*; D013972:Thyrotropin / Q000378:metabolism; D013974:Thyroxine / Q000378:metabolism; D013975:Thyroxine-Binding Proteins / Q000378:metabolism; D014284:Triiodothyronine / Q000378:metabolism
D013975:Thyroxine-Binding Proteins; D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine
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