Biochemical changes of the human semen produced by chlorambucil, testosterone propionate and human chorionic gonadotropin administration.
Biochemical analysis and morphological studies were carried out in six patients with lymphomas during and after withdrawal treatment with chlorambucil, testosterone propionate (TP) and human chorionic gonadotropins (HCG). In the course of the treatment with chlorambucil patients developed severe oligozoospermia or azoospermia. The spermatogenesis recovered after a variable period of time following suspension of treatment. During the drug administration seminal fructose and citric acid concentrations increase but the recovery after withdrawal takes a longer period of time. Simultaneous treatment with HCG or TP normalized the biochemical parameters without restoring spermatogenesis.
D000293:Adolescent; D000328:Adult; D002452:Cell Count; D002699:Chlorambucil / Q000009:adverse effects*; D006063:Chorionic Gonadotropin / Q000009:adverse effects*; D002951:Citrates / Q000378:metabolism; D005632:Fructose / Q000378:metabolism; D006801:Humans; D008223:Lymphoma / Q000188:drug therapy*; D008297:Male; D009845:Oligospermia / Q000139:chemically induced; D012661:Semen / Q000378:metabolism*; D013091:Spermatogenesis / Q000187:drug effects*; D013739:Testosterone / Q000009:adverse effects*
D006063:Chorionic Gonadotropin; D002951:Citrates; D002699:Chlorambucil; D005632:Fructose; D013739:Testosterone