title: Cancer of the pancreas in Olmsted County, Minnesota, 1935-1974.
abstract: All confirmed cases of pancreatic carcinoma in bona fida residents of Olmsted County, Minnesota, from 1935 through 1974 were identified and reviewed. The average annual age-adjusted incidence rates were 7.4 for males and 3.5 for females per 100,000 population. Rates increased with age for both sexes and increased slightly over the 40-year period of study, with lower incidence rates observed for rural inhabitants in the first 2 decades. At the time of diagnosis, almost 75% of patients were 60 years of age or older and adenocarcinoma was histologically identified in 92% of the cases. One-year survival was 11%, and all patients died within 3 years of the initial diagnosis. An association between pancreatic carcinoma and diabetes was noted. There does not appear to be a clear association with cholelithiasis or chronic pancreatitis. There was a high percentage (20%) of multiple primary carcinomas and an overrepresentation of metal workers observed among patients with pancreatic carcinoma.
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology* / Q000401:mortality; D000328:Adult; D000367:Age Factors; D000368:Aged; D000437:Alcoholism / Q000150:complications; D002769:Cholelithiasis / Q000150:complications; D048909:Diabetes Complications; D004785:Environmental Pollutants / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008910:Minnesota; D009378:Neoplasms, Multiple Primary / Q000453:epidemiology; D010190:Pancreatic Neoplasms / Q000453:epidemiology* / Q000401:mortality; D010195:Pancreatitis / Q000150:complications; D012424:Rural Population; D012737:Sex Factors; D014505:Urban Population
chemical_list: D004785:Environmental Pollutants