Clastogenic effects of frusemide on human leukocytes in culture.
The clastogenic effects of frusemide were investigated in vitro for 24 and 72 h. A mitodepressive activity was observed at both times. Chromosomal anomalies showed a dose response. There was a propensity for chromatid abnormalities. The chromosome mutational property of the drug is discussed in the light of earlier studies in vivo by the authors.
D002478:Cells, Cultured; D002869:Chromosome Aberrations; D002877:Chromosomes, Human / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005665:Furosemide / Q000494:pharmacology*; D006801:Humans; D007962:Leukocytes / Q000648:ultrastructure; D008297:Male; D008938:Mitosis / Q000187:drug effects
D005665:Furosemide