title: The relevance of the structural co-factor (chemogenic lesion) in adverse and toxic reactions of neuropsychotropic agents.
abstract: 1. Multidisciplinary methodologies in human and experimental investigations revealed that neuropsychotropic agents display multiple neural and extraneural "targets" or bioreceptors. 2. The adverse and toxic reactions would be, in essence, the expression of a reversible or irreversible "chemogenic lesion" resulting from the molecular interactions among the chemical agents and the morpho-chemical correlates of the organism at any level of the structural organization. 3. In pathogenic terms, this "chemogenic lesion" appears as a patho-chemical condition or a dynamic state of interacting chemical and biological mechanisms rather than a single cause.
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology; D001923:Brain Chemistry; D006651:Histocytochemistry; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D008854:Microscopy, Electron; D011619:Psychotropic Drugs / Q000009:adverse effects*; D013045:Species Specificity
chemical_list: D011619:Psychotropic Drugs