[Comparison of the clinical and immunological indices in children with diabetes mellitus and obesity].
Complex clinical and laboratory research of nonspecific immunobiological reactivity was conducted in 86 children (35 with diabetes mellitus, 25 with obesity, and 26 healthy children), aged from 3 to 14 years. Lysozyme activity and complement titre were studied during the disease. Reduced reactive possibilities of the organism were demonstrated in diabetic children; reduction of these parameters was directly proportional to the severity of the main process and the extent of decompensation. In obese patients the parameters of nonspecific reactivity tests were higher than in healthy children, and glucose tolerance was disturbed; this was apparently connected with stress of the compensatory-defense mechanisms of the organism. A distinct reduction of the parameters in this group of children under the effect of unfavourable factors pointed to exhaustion of the compensatory mechanisms. Obese patients should be referred to the group of children will increased risk, both in respect to diabetes mellitus and to other diseases. The indices under study could  be applied as tests characterizing not only the immunobiological reactivity and the defense-adaptive mechanisms of the organism, but also the severity and phase of the disease.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003165:Complement System Proteins / Q000032:analysis; D003920:Diabetes Mellitus / Q000276:immunology*; D005951:Glucose Tolerance Test; D006029:Glycosuria / Q000652:urine; D006801:Humans; D007113:Immunity, Innate; D009113:Muramidase / Q000097:blood; D009765:Obesity / Q000276:immunology*; D011236:Prediabetic State / Q000276:immunology
D003165:Complement System Proteins; D009113:Muramidase
Sopostavalenie kliniko-immunologicheskikh pokazateleĭ u deteĭ, bol'nykh sakharnym diabetom i ozhireniem.