Mammary tumor and leukemia in male Sprague-Dawley rats evoked by a series of intragastric administration of 7,12-dimethylbenz(a)anthracene.
A series of administration of 7,12-dimethylbenz[a]anthracene given at biweekly intervals by gastric intubation of juvenile male rats of the Sprague-Dawley strain elicited considerable number of mammary carcinomas, leukemias, and ear duct tumors. The evoked leukemia shared two main types; 51.6% of erythroblastic stem cell and 48.4% of myelogenous.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000231:Adenocarcinoma, Papillary / Q000139:chemically induced; D000818:Animals; D001551:Benz(a)Anthracenes; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced; D004428:Ear Neoplasms / Q000139:chemically induced; D006412:Hematopoietic Stem Cells; D007942:Leukemia, Experimental; D007951:Leukemia, Myeloid / Q000139:chemically induced*; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced*; D010212:Papilloma / Q000139:chemically induced; D051381:Rats
D001551:Benz(a)Anthracenes; D015127:9,10-Dimethyl-1,2-benzanthracene