Uptake studies of taurine in vivo and its effects on the course of experimental focal epilepsy in rats.
The passage of orally administered taurine across the intestinal wall to the blood plasma and target sites of neuromuscular excitability has been studied. This has been correlated with the effect of repeated oral dosing on the manifestations of cobalt-induced epilepsy in the rat. The blood-brain barrier and the organ distribution of taurine uptake have important implications in testing its effect on hyperexcitability phenomena.
D000818:Animals; D001812:Blood-Brain Barrier; D002540:Cerebral Cortex / Q000187:drug effects; D003035:Cobalt; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004828:Epilepsies, Partial / Q000139:chemically induced / Q000188:drug therapy*; D005260:Female; D009132:Muscles / Q000187:drug effects; D051381:Rats; D013654:Taurine / Q000378:metabolism* / Q000627:therapeutic use
D013654:Taurine; D003035:Cobalt