title: Randomized steroid therapy of human kidney transplant rejection.
abstract: This randomized, double-blind study failed to show any therapeutic benefit of a 30-mg/kg bolus over a 3-mg/kg bolus of methylprednisolone for the treatment of acute kidney transplant rejection. Since there was a slight associated increase in infections and septic mortality, routine use of high-dose methylprednisolone bolus therapy is not recommended or justified.
mesh_terms: D004311:Double-Blind Method; D006084:Graft Rejection / Q000187:drug effects*; D006801:Humans; D016030:Kidney Transplantation; D008775:Methylprednisolone / Q000627:therapeutic use*; D011897:Random Allocation
chemical_list: D008775:Methylprednisolone