Is sulphated blood-group substance in pancreas a factor in cystic fibrosis?
The present study showed that the pancreas of two monkey species contained sulphated blood-group substance. Such strongly anionic molecules are known to bind calcium, and their solutions form gels in the presence of cations. It is suggested that such a mechanism may be involved in cystic fibrosis.
D000818:Animals; D001345:Autoradiography; D001789:Blood Group Antigens; D002118:Calcium / Q000097:blood; D002521:Cercopithecus; D003550:Cystic Fibrosis / Q000097:blood*; D006023:Glycoproteins / Q000097:blood*; D000882:Haplorhini; D008252:Macaca fascicularis; D010179:Pancreas / Q000378:metabolism; D013431:Sulfates / Q000378:metabolism
D001789:Blood Group Antigens; D006023:Glycoproteins; D013431:Sulfates; D002118:Calcium