Effects of enantiomeric homogeneity on the in vitro metabolism and in vivo anticancer activity of (+)- and (-)-cyclophosphamide.
D000171:Acrolein / Q000378:metabolism; D000478:Alkylation; D000818:Animals; D000970:Antineoplastic Agents; D003520:Cyclophosphamide / Q000378:metabolism / Q000494:pharmacology*; D003600:Cytosol / Q000378:metabolism; D066298:In Vitro Techniques; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism; D010752:Phosphoramide Mustards / Q000378:metabolism; D051381:Rats; D013237:Stereoisomerism
D000970:Antineoplastic Agents; D010752:Phosphoramide Mustards; D000171:Acrolein; D003520:Cyclophosphamide