Study of platelet aggregation in vivo. III. Effect of pentoxifylline.
Pentoxifylline (Trental) a new vasoactive agent was shown to be a powerful inhibitor of ADP and serotonin induced platelet aggregation of monkey platelets in vivo. A linear dose response curve was demonstrated between 6 and 24 mg/kg of i.v. pentoxifylline.
D000244:Adenosine Diphosphate / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology; D000818:Animals; D000925:Anticoagulants; D004305:Dose-Response Relationship, Drug; D005260:Female; D000882:Haplorhini; D008251:Macaca; D010431:Pentoxifylline / Q000008:administration & dosage / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D012701:Serotonin / Q000008:administration & dosage / Q000494:pharmacology; D012702:Serotonin Antagonists; D013805:Theobromine / Q000031:analogs & derivatives*
D000925:Anticoagulants; D012702:Serotonin Antagonists; D012701:Serotonin; D000244:Adenosine Diphosphate; D013805:Theobromine; D010431:Pentoxifylline