Altered neuroanatomical organization in the central nervous system of the genetically obese (ob/ob) mouse.
Genetically obese (C57BL/6J ob/ob) mice have significantly reduced brain weights (-14.6%) and cortical brain volumes (-7.9%) compared to lean control mice (C57BL/6J +/+). Morphometric analyses of soma cross-sectional areas of individual neurons in select brain region also reveals significant alterations in the ob/ob mouse. Neurons from 8 out of 9 brain regions, including the ventromedial hypothalamic nucleus, show significantly decreased soma cross-sectional areas in ob/ob mice compared to controls. Only lateral hypothalamic area neurons have equivalent soma cross-sectional areas for these two mouse strains. The decreased brain weight and volume coupled with the observed morphometric changes in individual neuronal soma size suggest that the ob/ob mouse brain differs considerably from that of controls. These differences may underlie some of the endocrine abnormalities seen in this genetic obesity syndrome.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001921:Brain / Q000033:anatomy & histology*; D001933:Brain Stem / Q000033:anatomy & histology; D002452:Cell Count; D002540:Cerebral Cortex / Q000033:anatomy & histology; D004027:Diencephalon / Q000033:anatomy & histology; D007328:Insulin / Q000097:blood; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese / Q000235:genetics*; D009474:Neurons / Q000166:cytology; D009929:Organ Size
D001786:Blood Glucose; D007328:Insulin