title: Meningiomas in five members of a family over two generations, in one member simultaneously with acoustic neurinomas.
abstract: Despite four reports of familial occurrence of meningiomas, the inheritance of this tumor remains an open question. We describe a family in which four members in two generations had meningiomas without evidence of neurofibromatosis. Another member of the family, however, had multiple meningiomas and bilateral acoustic neurinomas, while yet another had multiple café-au-lait spots. We suspect that a highly unusual presentation of neurofibromatosis explains this otherwise very unlikely occurrence.
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000150:complications / Q000235:genetics*; D008579:Meningioma / Q000150:complications / Q000235:genetics*; D008875:Middle Aged; D009456:Neurofibromatosis 1 / Q000235:genetics; D009464:Neuroma, Acoustic / Q000150:complications*; D010375:Pedigree; D013120:Spinal Cord Neoplasms / Q000235:genetics