title: Metabolism of arylacetic acids. 1. The fate of 1-naphthylacetic acid and its variation with species and dose.
abstract: 1. [Carboxy-14C]-1-Naphthylacetic acid has been administered to man, 6 primate species and 4 other mammalian species and the urinary metabolites examined by radiochromatogram scanning and reverse isotope dilution. Animals all received a dose of 100 mg/kg and man received 5 mg, orally. 2. Most species excreted at least 60% of the 14C in the urine in 48 h. Unchanged acid was a minor (0-17% dose) excretion product in all species except the cynomolgus monkey (35%). 3. In man, in 24 h 95% of 14C was excreted as 1-naphthylacetyl-glucuronide and 5% as 1-naphthylacetyltaurine. 4. 1-Naphthylacetylglucuronide was the major excretion product in all species except the bushbaby (21% dose) and the cat, which did not form this conjugate. 5. 1-Naphthylacetylglutamine was formed only by the cynomolgus, squirrel and capuchin monkeys and marmoset, and in no case accounted for more than 3% dose. 6. 1-Naphthylacetylglycine was found in the urines of 4 primate and 3 non-primate species, and was the major metabolite in the squirrel monkey, bushbaby and cat. 7. 1-Naphthylacetyltaurine was excreted by all species except the rabbit and the fruit bat. It was a major excretion product in the squirrel and capuchin monkeys, the marmoset and the cat. 8. The influence of dose on the pattern of metabolism and excretion of 1-naphthylacetic acid has been investigated in the rat.
mesh_terms: D000818:Animals; D002143:Callitrichinae; D002415:Cats; D002685:Chiroptera; D004305:Dose-Response Relationship, Drug; D005701:Galago; D005965:Glucuronates / Q000652:urine; D005973:Glutamine / Q000652:urine; D005998:Glycine / Q000652:urine; D000882:Haplorhini; D006801:Humans; D008252:Macaca fascicularis; D008253:Macaca mulatta; D009280:Naphthaleneacetic Acids / Q000378:metabolism*; D011817:Rabbits; D051381:Rats; D012453:Saimiri; D013045:Species Specificity; D013654:Taurine / Q000652:urine
chemical_list: D005965:Glucuronates; D009280:Naphthaleneacetic Acids; D005973:Glutamine; D013654:Taurine; D005998:Glycine