Treatment and follow-up of patients with infertility due to spermagglutinins.
A therapeutic trial based on pharmacologically induced azoospermia followed by the administration of corticosteroids was carried out in 48 patients with infertility due to spermagglutinins. Three types of responses were observed: type A, no modifications in the blood and spermagglutinating (SA) titer (19 cases); type B, disappearance or significant decrease in SA titer during treatment, with return to normal values upon resumption of spermatogenesis (7 cases); and type C, disappearance or significant decrease in SA titer for at least 1 year after stopping treatment (22 cases). Within the 1st year after stopping therapy only men who responded in type C fashion were able to impregnate partners, three pregnancies ended in abortion and nine in normal births.
D001323:Autoantibodies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007248:Infertility, Male / Q000209:etiology / Q000276:immunology / Q000628:therapy*; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D009845:Oligospermia / Q000188:drug therapy; D011247:Pregnancy; D013073:Sperm Agglutination; D013094:Spermatozoa / Q000276:immunology; D013739:Testosterone / Q000627:therapeutic use
D001323:Autoantibodies; D013739:Testosterone; D008775:Methylprednisolone