Marchiafava-Bignami disease.
Marchiafava-Bignami disease was diagnosed postmortem in a 39-year-old man who drank excessive amounts of white port wine. This is the fifth report of the disease in a native North-American with no Italian ancestry. The lesion involved the corpus callosum and hippocampal commissure but spared the anterior commissure, middle cerebellar peduncles, optic chiasm, and centrum semiovale. Wernicke-Korsakoff encephalopathy and pellagroid neuronal changes were also present.
D000328:Adult; D000437:Alcoholism / Q000150:complications* / Q000473:pathology; D003337:Corpus Callosum / Q000473:pathology*; D003711:Demyelinating Diseases / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008297:Male; D008326:Mammillary Bodies / Q000473:pathology; D009044:Motor Cortex / Q000473:pathology