[Studies on the mechanism of action of vascular spasmolytics. 3. Effect of nitroprusside sodium, nitroglycerin, prenylamine and verapamil on the fluoride-induced contracture of the isolated coronary artery].
On isolated coronary arteries of cattle, nitroprusside-sodium, nitroglycerol, prenylamine, and verapamil were studied for their spasmolytic effects on a contracture induced by fluoride ions. With this contracture model, which is independent of extracellular calcium, nitroprosside-sodium and nitroglycerol showed strong spasmolytic action. Verapamil proved ineffective, and the effectiveness of prenylamine was strongly reduced. The results lend support to earlier findings suggesting that nitroglycerol and nitroprusside-sodium are endowed with a relaxation mechanism different from that of verapamil and analogously acting compounds.
D000818:Animals; D001158:Arteries / Q000187:drug effects*; D002417:Cattle; D003331:Coronary Vessels / Q000187:drug effects; D005292:Ferricyanides / Q000494:pharmacology*; D005459:Fluorides / Q000037:antagonists & inhibitors*; D005996:Nitroglycerin / Q000494:pharmacology*; D009599:Nitroprusside / Q000494:pharmacology*; D011299:Prenylamine / Q000494:pharmacology*; D014661:Vasoconstriction / Q000187:drug effects*; D014700:Verapamil / Q000494:pharmacology*
D005292:Ferricyanides; D009599:Nitroprusside; D014700:Verapamil; D005996:Nitroglycerin; D011299:Prenylamine; D005459:Fluorides
Versuche zum Wirkungsmechanismus von Gefässspasmolytika. 3. Wirkung von Nitroprussid-Natrium, Nitroglyzerin, Prenylamin und Verapamil an der Fluorid-induzierten Kontraktur isolierter Koronararterien.