The toxicity of 1-amino-3-chloro-2-propanol hydrochloride (CL88,236) in the rhesus monkey.
The toxicity of 1-amino-3-chloro-2-propanol is associated with acute histopathological change in the medulla oblongata, characterised lesions of focal oedema. Continued administration results in neurological scars. Lesions can be induced at dose levels of 50 mg . kg-1 day-1. Clinical manifestations of neurological involvement are periods of slight incoordination and loss of balance in a few animals only.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000187:drug effects; D003272:Contraceptive Agents, Male / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D000882:Haplorhini; D008253:Macaca mulatta; D008297:Male; D011412:Propanolamines / Q000633:toxicity*
D003272:Contraceptive Agents, Male; D011412:Propanolamines