Lack of effect of butylated hydroxytoluene on dimethylhydrazine-induced colon carcinogenesis in rats.
Rats were given 6600 ppm of butylated hydroxytoluene (BHT) in the diet along with 10 weekly oral doses of dimethylhydrazine (DMH, 30 MG/KG). The incidence and mean number of colonic tumors produced were similar to that of rats given DMH alone. Thus, BHT did not provide any protective effect against colon carcinogenesis.
D000230:Adenocarcinoma / Q000139:chemically induced*; D000818:Animals; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D003110:Colonic Neoplasms / Q000139:chemically induced*; D003408:Cresols / Q000494:pharmacology; D004127:Dimethylhydrazines / Q000037:antagonists & inhibitors; D004379:Duodenal Neoplasms / Q000139:chemically induced; D008297:Male; D008763:Methylhydrazines / Q000037:antagonists & inhibitors; D009374:Neoplasms, Experimental / Q000139:chemically induced; D051381:Rats
D003408:Cresols; D004127:Dimethylhydrazines; D008763:Methylhydrazines; D002084:Butylated Hydroxytoluene