title: Nutritional effects of field bean (Vicia faba L.) proteinase inhibitors fed to rats.
abstract: 1. Weanling rats were fed on purified-casein diets containing active and inactive (autoclaved) field bean (Vicia faba L.) proteinase inhibitors (PI) at levels of 1.25, 2.5, 5.0 and 10 g/kg. Diets containing raw- and autoclaved-field-bean meal (FBM) were also given. The body-weight gain, protein efficiency ratio (PER); i.e. the ratio of the live weight gain in g/g of protein consumed and apparent nitrogen digestibility were determined 7, 14 and 21 d after the start of the trial. 2. Significant growth depression (P less than 0.001) was observed in rats given diets containing 2.5 g/kg PI (27--35%). In rats fed on raw FBM growth depression was severe after 7 d (57%). 3. Food intake was depressed at PI inclusion levels of 5 g/kg and higher between 14 and 21 d. 4. PER was depressed significanlty (33-44%) in rats given diets containing the active PI at all levels after 7 d. The protein utilization of all casein diets was higher than that of the FBM diets. 5. Apparent N digestibility was depressed in rats fed on diets containing 10 g/kg PI by 9 and 7% at 14 and 21 d respectively. The N digestibility of both raw and heated FBM was similar at approximately 84%. 6. It was concluded that the PI are not the main factors responsible for the growth depression observed when raw FBM is fed to rats.
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D003864:Depression, Chemical; D004032:Diet; D004044:Dietary Proteins / Q000378:metabolism; D004063:Digestion; D004435:Eating / Q000187:drug effects; D007887:Fabaceae / Q000378:metabolism*; D008297:Male; D010946:Plants, Medicinal; D011480:Protease Inhibitors / Q000494:pharmacology*; D051381:Rats
chemical_list: D004044:Dietary Proteins; D011480:Protease Inhibitors