Effects of diphenylhydantoin and chloroquine on monkey liver microsomal mixed-function oxidases.
Sixteen adult male squirrel monkeys (Saimiri sciureus) were randomly divided into three treatment groups and one control group. Each treatment group received 10 mg/kg oral doses of diphenylhydantoin and/or chloroquine. Following sacrifice, in vitro assays for activity of liver microsomal mixed-function oxidases were run. The assays confirmed diphenylhydantoin as a potent inducer of mixed-function oxidases. Chloroquine administration had little affect on the enzymes assayed and did not inhibit the diphenylhydantoin induction.
D000818:Animals; D002738:Chloroquine / Q000494:pharmacology*; D004347:Drug Interactions; D000882:Haplorhini; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D009929:Organ Size / Q000187:drug effects; D010088:Oxidoreductases / Q000378:metabolism*; D010672:Phenytoin / Q000494:pharmacology*; D012453:Saimiri
D010672:Phenytoin; D002738:Chloroquine; D006899:Mixed Function Oxygenases; D010088:Oxidoreductases