The insomnia of 'sleeping in a strange place': effects of l-tryptophane.
Forty-two normal human subjects were studied in the sleep laboratory for one night each. Fourteen were given placebo at bedtime, 14 took l-tryptophane 1 g, and 14 took l-tryptophane 3 g. Both tryptophane groups had significantly lower sleep latency than the placebo group. The usually discarded 'first laboratory night' produces a mild situational insomnia in normal persons and thus can be useful in certain sleep studies.
D000223:Adaptation, Psychological; D000328:Adult; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D010919:Placebos; D012890:Sleep / Q000187:drug effects; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D013997:Time Factors; D014364:Tryptophan / Q000627:therapeutic use*
D010919:Placebos; D014364:Tryptophan