Stability studies on horse antithymocyte globulin.
Two equine antithymocyte globulin preparations were studied with respect to their relative rosette inhibition activity after storage at 4 and 25 C. After storage at 4 C for 48 months no activity loss was observed; 25 C storage resulted in fragmentation and eventual loss of relative rosette inhibition activity. A third preparation was studied by monkey skin graft prolongation. During a 1-year period, there was no loss of immunosuppressive activity as measured by this method and the rosette inhibition assay.
D000818:Animals; D000961:Antilymphocyte Serum / Q000032:analysis*; D002499:Centrifugation, Density Gradient; D004355:Drug Stability; D006085:Graft Survival; D000882:Haplorhini; D006736:Horses; D007158:Immunologic Techniques; D007166:Immunosuppressive Agents / Q000032:analysis; D008253:Macaca mulatta; D016038:Skin Transplantation; D013601:T-Lymphocytes / Q000276:immunology*; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous
D000961:Antilymphocyte Serum; D007166:Immunosuppressive Agents