A facile one-step synthesis of cysteinyldopas using mushroom tyrosinase.
A convenient one-step procedure, based upon the tyrosinase co-oxidation of dopa and cysteine, is reported for the synthesis of 5-S-cysteinyldopa (I) in 74% yield. Secondary products of the reaction turned out to be 2-S-cysteinyldopa (II, 14%), 2,5-S, S-dicysteinyldopa (iv, 5%), and the hitherto unknown 6-S-cysteinyldopa (III, approximately 1%).
D003548:Cysteinyldopa / Q000138:chemical synthesis*; D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives*; D014442:Monophenol Monooxygenase
D003548:Cysteinyldopa; D004295:Dihydroxyphenylalanine; D014442:Monophenol Monooxygenase