title: Transfer of antibacterial immunity by "Immune" RNA from animals treated with pseudomonas lipopolysaccharide.
abstract: The humoral primary immune response to Pseudomonas aeruginosa lipopolysaccharide was studied. Mice immunized with various doses of LPS developed anti-LPS antibodies. Antibody activity was due to 19S and 7S immunoglobulins. Extracts rich in RNA from spleen cells of immune mice were able to transfer specific anti-LPS response to normal recipients. Immunogenic antigen contamination of RNA was ruled out by a variety of controls.
mesh_terms: D000818:Animals; D000917:Antibody Formation; D007116:Immunization, Passive; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008070:Lipopolysaccharides; D051379:Mice; D011135:Polysaccharides, Bacterial; D011550:Pseudomonas aeruginosa / Q000276:immunology; D012313:RNA; D013154:Spleen / Q000276:immunology
chemical_list: D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008070:Lipopolysaccharides; D011135:Polysaccharides, Bacterial; D012313:RNA