title: Influence of various inhibitors on alkaline phosphatase in calicifying hamster molars, employing paranitrophenyl phosphate as substrate.
abstract: In mineralizing hamster molars, the influence of several inhibitors on p-NPP-ase has been demonstrated, and compared with their effect on PPi-ase, known to belong to the same enzyme. Whereas the latter activity is much more physiological, p-NPP is a better substrate to distinguish between the effects of bivalent cations on the enzyme or the substrate.
mesh_terms: D000469:Alkaline Phosphatase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000818:Animals; D006224:Cricetinae; D004164:Diphosphonates / Q000494:pharmacology; D004492:Edetic Acid / Q000494:pharmacology; D008963:Molar / Q000201:enzymology* / Q000502:physiology; D009596:Nitrophenols / Q000378:metabolism*; D009943:Organophosphorus Compounds / Q000378:metabolism; D014074:Tooth Calcification; D015032:Zinc / Q000494:pharmacology
chemical_list: D004164:Diphosphonates; D009596:Nitrophenols; D009943:Organophosphorus Compounds; D004492:Edetic Acid; D000469:Alkaline Phosphatase; D015032:Zinc