[Change in the metabolism of 7,12-dimethylbenz(a)anthracene under the influence of vitamin A].
The in vitro metabolism of 7,12-dimethylbenz(a)anthracene in its incubation with the liver microsomes, the liver and mammary gland homogenates of rats, kept on vitamin A-enriched diet, was studied. Vitamin A inhibited the formation of lipophilic metabolites and increased the generation of water-soluble metabolites. The amount of lipophilic metabolites extracted from the microsomes and the liver and mammary gland homogenates were decreased by a factor of 2.2 and 5, respectively. The amount of unmetabolized DMBA in the liver microsomes was the same in control and experimental animals.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000378:metabolism*; D000818:Animals; D001551:Benz(a)Anthracenes / Q000378:metabolism*; D005260:Female; D008321:Mammary Glands, Animal / Q000378:metabolism* / Q000648:ultrastructure; D008861:Microsomes / Q000378:metabolism*; D008862:Microsomes, Liver / Q000378:metabolism; D051381:Rats; D014801:Vitamin A / Q000494:pharmacology*
D001551:Benz(a)Anthracenes; D014801:Vitamin A; D015127:9,10-Dimethyl-1,2-benzanthracene
Izmenenie metabolizma 7,12-dimetilbenz(a)antratsena pod vliianiem vitamina A.