Somatostatin inhibits the mitogenic effect of thyroliberin.
The effect of somatostatin and of thyroliberin on the mitotic incidence in the organ-cultured anterior pituitary lobe of the rat was investigated, using the colchicine metaphase-arrest technique. It was found that somatostatin added to the culture medium, together with thyroliberin, blocked the mitogenic effect of the latter.
D000818:Animals; D003864:Depression, Chemical; D008297:Male; D008938:Mitosis / Q000187:drug effects*; D009924:Organ Culture Techniques; D010903:Pituitary Gland, Anterior / Q000166:cytology / Q000187:drug effects; D051381:Rats; D013004:Somatostatin / Q000494:pharmacology*; D013973:Thyrotropin-Releasing Hormone / Q000037:antagonists & inhibitors*
D013004:Somatostatin; D013973:Thyrotropin-Releasing Hormone