Tuberculous meningitis in children: a retrospective study of 79 patients, with an analysis of prognostic factors.
A study of 79 cases of tuberculous meningitis in children, with an emphasis on prognostic factors, was conducted by means of a review of hospital records and completion of a follow-up questionnaire. The survival rate was 62%. Stage 3 disease (with severe changes in the sensorium and often severe neurologic abnormalities) at the time of admission, age 3 years or less, associated miliary tuberculosis and delay in the initiation of therapy correlated significantly with poor outcome. Severe neurologic complications in the acute phase were also related to poor outcome and severe sequelae. General recommendations pertaining to treatment are made.
D000367:Age Factors; D000995:Antitubercular Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D005260:Female; D006760:Hospitalization; D006801:Humans; D007223:Infant; D008297:Male; D011379:Prognosis; D011792:Quebec; D012189:Retrospective Studies; D013256:Steroids / Q000627:therapeutic use; D014374:Tuberculin Test; D014390:Tuberculosis, Meningeal / Q000150:complications / Q000175:diagnosis / Q000401:mortality / Q000628:therapy; D014391:Tuberculosis, Miliary / Q000150:complications
D000995:Antitubercular Agents; D013256:Steroids