title: [Monoamine oxidase activity of the brain of Locusta migratoria in normal conditions and after intoxication by two insecticides: chlordimeform and dieldrin].
abstract: Our investigations have shown up an MAO activity in locust brain, by the use of a radio-isotopic method, as much at larval as at adult stage. This MAO activity is in a sample of 34,3 dpm/mg of brain tissue (wet weight). Investigations have also been undertaken on effects of dieldrin and chlordimeform poisoning on this MAO activity. Even at sublethal dosages, chlordimeform causes a significant inhibition of MAO activity in vivo. This finding is in accordance with Beeman and Matsumura's work in vitro. Moreover, acute poisoning by dieldrin produces more than 60% of inhibition of MAO, 3 hours after administration of 115 microng of this insecticide by injection in the hoemocelian cavity.
mesh_terms: D000578:Amidines / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000201:enzymology; D002742:Chlorphenamidine / Q000494:pharmacology*; D004026:Dieldrin / Q000494:pharmacology*; D005260:Female; D006110:Grasshoppers / Q000187:drug effects*; D007814:Larva; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology
chemical_list: D000578:Amidines; D008996:Monoamine Oxidase Inhibitors; D008995:Monoamine Oxidase; D002742:Chlorphenamidine; D004026:Dieldrin
vernacular_title: Sur l'activité monoaminoxydasique du cerveau de Locusta migratoria dans les conditions normales et après intoxication par deux insecticides: le chlordiméform et la diéldrine.