Immunoglobulin production by human-mouse somatic cell hybrids.
Studies on immunoglobulin production in human-mouse somatic cell hybrids suggest: 1. The structural genes for heavy chain immunoglobulins are carried on chromsome 6, probably on the short arm or the proximal half of the long arm of the chromosome. 2. The structural gene for kappa light chain immunoglobulin may be carried on chromsome 11. 3. The occurrence of immunoglobulin molecules on the cell surface requires the presence of chromosome 2.
D000818:Animals; D002874:Chromosome Mapping; D002877:Chromosomes, Human; D005796:Genes; D006801:Humans; D006822:Hybrid Cells / Q000276:immunology*; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D007147:Immunoglobulin Light Chains / Q000235:genetics; D007136:Immunoglobulins / Q000096:biosynthesis / Q000235:genetics*; D008291:Malate Dehydrogenase / Q000235:genetics; D051379:Mice; D011947:Receptors, Antigen, B-Cell / Q000235:genetics; D013482:Superoxide Dismutase / Q000235:genetics
D007143:Immunoglobulin Heavy Chains; D007147:Immunoglobulin Light Chains; D007136:Immunoglobulins; D011947:Receptors, Antigen, B-Cell; D008291:Malate Dehydrogenase; D013482:Superoxide Dismutase