On the interaction of drugs with the cholinergic nervous system. II. Cross-tolerance between phencyclidine derivatives and cholinergic drugs.
A symmetrical cross-tolerance was found between two phencyclidine derivatives--phencyclidine and cyclohexamine--and also between two cholinergic drugs--physostigmine and oxotremorine. On the other hand, mice rendered tolerant to the phencyclidine derivatives showed cross-tolerance to these cholinergic drugs, but no cross-tolerance was observed in the opposite direction. The applicability of such experiments to the elucidation of neurochemical interactions of centrally acting drugs is discussed.
D000818:Animals; D004361:Drug Tolerance; D005260:Female; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010275:Parasympathetic Nervous System / Q000187:drug effects*; D010277:Parasympathomimetics / Q000494:pharmacology*; D010622:Phencyclidine / Q000031:analogs & derivatives* / Q000494:pharmacology
D010277:Parasympathomimetics; D010622:Phencyclidine