title: Metabolic response to isologous transplantation of small numbers of isolated islets of Langerhans in the rat.
abstract: Pancreatic islets from adult donors were transplanted intraportally into 32 inbred, adult AGUS rats with streptozotocin diabetes. The islets were isolated with collagenase and counted individually. A relationship between the number of islets transplanted and the metabolic response could be demonstrated. Transplantation of less than 200 islets did not change the diabetic state. Rats receiving 200-220 improved, while recipients of 240-800 islets all exhibited normal values of blood glucose, plasma insulin, urine volume and urine glucose. The glucose tolerance, however, remained abnormal in all animals.
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000628:therapy*; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006029:Glycosuria; D007328:Insulin / Q000097:blood; D016381:Islets of Langerhans Transplantation; D008297:Male; D051381:Rats; D014185:Transplantation, Isogeneic
chemical_list: D001786:Blood Glucose; D007328:Insulin; D005947:Glucose