[Effect of EDTA on the activity of aminolevulinic dehydratase in vitro and in vivo].
To blood samples taken from persons who are not exposed to the effect of lead, ions Pb++ were added. Then lowering of the activity of aminolevulinic dehydratase (ALAD) in proportion to an amount of lead added was observed. Parallel introduction of ions Pb++ and EDTA prevented a significant lowering of ALAD activity. The persons who were exposed to chronic effect of lead, with a lowered activity of ALAD, were given EDTA, as a treatment. Significant increase in the form of doubled activity of the enzyme occurred in the period between 8-16 day of treatment.
D004492:Edetic Acid / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D006836:Hydro-Lyases / Q000097:blood*; D007854:Lead / Q000037:antagonists & inhibitors; D007855:Lead Poisoning / Q000188:drug therapy / Q000201:enzymology; D000623:Porphobilinogen Synthase / Q000097:blood*
D007854:Lead; D004492:Edetic Acid; D006836:Hydro-Lyases; D000623:Porphobilinogen Synthase
Wpływ EDTA na aktywność dehydratazy aminolewulinianowej w warunkach in vitro i in vivo.