[Effect of hypokinesia on the resistance of animals to the action of chemical substances].
Resistance of rats exposed to 20-day hypokinesia to high concentrations of vapors of ethylacetate, dioxan, and liquid fluorochlorocarbon was studied. As compared with controls, lethality of the hypokinetic animals increased upon ethylacetate and dioxan breathing and decreased upon intoxication with liquid fluorochlorocarbon. The hypokinetic animals showed decreased resistance to chronic effects of ethylacetate and perfluorated ester vapors (at a concentration of 10 and 100 mg/m3 for 90 and 30 days, respectively). This was suggested by functional and pathomorphological studies.
D000085:Acetates / Q000633:toxicity; D000818:Animals; D004146:Dioxanes / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance; D004781:Environmental Exposure; D005466:Fluorocarbons / Q000633:toxicity; D006846:Hydrocarbons, Halogenated / Q000633:toxicity; D008297:Male; D051381:Rats; D012149:Restraint, Physical / Q000009:adverse effects*; D013997:Time Factors
D000085:Acetates; D004146:Dioxanes; D005466:Fluorocarbons; D006846:Hydrocarbons, Halogenated
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