[Modifying effect of DDT and of its various metabolites on the toxic effect of 7,12-dimethylbenz(alpha)anthracene].
In rats a preliminary three times injection of DDT in doses of 10 and 100 mg/Kg eliminated completely DMBA (30 mg/per 100 g of weight) lethal effect and prevented or decreased the development of adrenal necrosis. Among the metabolites under study (DDT, DDON, DDMU, DDE, DDA, DVR) DDE was found to render the strongest protective action in its single administration in a dose of 10 mg/Kg a day before the exposure to DMBA.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000037:antagonists & inhibitors / Q000633:toxicity*; D000307:Adrenal Gland Diseases / Q000139:chemically induced / Q000517:prevention & control; D000818:Animals; D001551:Benz(a)Anthracenes / Q000633:toxicity*; D056486:Chemical and Drug Induced Liver Injury; D003634:DDT / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology*; D003633:Dichlorodiphenyl Dichloroethylene / Q000494:pharmacology; D003632:Dichlorodiphenyldichloroethane / Q000494:pharmacology; D004336:Drug Antagonism; D005260:Female; D008107:Liver Diseases / Q000517:prevention & control; D009336:Necrosis; D051381:Rats
D001551:Benz(a)Anthracenes; D003633:Dichlorodiphenyl Dichloroethylene; D015127:9,10-Dimethyl-1,2-benzanthracene; D003634:DDT; D003632:Dichlorodiphenyldichloroethane
Modifitsiruiushchee deĭstvie DDT i nekotorykh ego metabolitov na toksicheskiĭ effekt 7,12-dimetilbenz(alpha)antratsena.