title: Investigations with bioactivated polymethylmethacrylates.
abstract: Compound bone cement on a PMMA base with an additive of bioactive glass ceramic particles in different portions and different particle sizes are tested in animal experiments. The tissue reactions to extracorporal polymerized specimens and to in situ polymerized specimens are observed. The experiments with an implantation period up to six months demonstrate a tight bonding between the newly formed osseous tissue and the glass ceramic particles at the interface. The inflammatory reactions in the vicinity of the implant are small. It is the objective of the investigations to improve the adherance of the bone cement at the interface to achieve a more durable anchorage of bone cement in the tissue.
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001843:Bone Cements / Q000494:pharmacology*; D001861:Bone Regeneration; D001842:Bone and Bones / Q000033:anatomy & histology / Q000187:drug effects; D002516:Ceramics; D005898:Glass; D008768:Methylmethacrylates / Q000494:pharmacology*; D010316:Particle Size; D011108:Polymers; D051381:Rats; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D001843:Bone Cements; D008768:Methylmethacrylates; D011108:Polymers