Structure of the human fetal globin gene locus.
We have derived a 'map' of restriction enzyme sites in and around the human gamma-globin genes. This has enabled us to show that there are two gamma-globin genes per haploid set, that the genes contain 'introns' within the same regions of DNA as the human beta and delta-globin genes, and that the genes are 3,500 base pairs apart. We conclude that the correct gene organisation of the human beta-like globin locus is GgammaAgammadeltabeta.
D002874:Chromosome Mapping; D004262:DNA Restriction Enzymes; D005319:Fetal Hemoglobin / Q000235:genetics*; D005796:Genes; D008040:Genetic Linkage; D005914:Globins / Q000235:genetics*; D006801:Humans; D014158:Transcription, Genetic
D005914:Globins; D005319:Fetal Hemoglobin; D004262:DNA Restriction Enzymes