title: The acute effects of various cytotoxic compounds injected into the prostate glands of dogs.
abstract: The acute effects of direct injections with various cytotoxic compounds into the prostates of adult dogs were studied microscopically. The effects remained localised to the site of injection, with no diffusion of the agents into other areas of the prostate. No systemic effects were observed despite the high concentrations used. The main histological changes consisted of local aseptic necrosis at the injection site surrounded by atrophy of the acinar epithelium.
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D003609:Dactinomycin / Q000009:adverse effects; D004285:Dogs; D005009:Ethoglucid / Q000009:adverse effects; D005472:Fluorouracil / Q000009:adverse effects; D007249:Inflammation / Q000209:etiology; D007267:Injections / Q000379:methods; D008297:Male; D008937:Mitomycins / Q000009:adverse effects; D009336:Necrosis / Q000209:etiology; D011467:Prostate / Q000187:drug effects*; D013852:Thiotepa / Q000009:adverse effects
chemical_list: D000970:Antineoplastic Agents; D008937:Mitomycins; D003609:Dactinomycin; D005009:Ethoglucid; D013852:Thiotepa; D005472:Fluorouracil