title: [Therapy of chronic arterial occlusive disease. Studies with an orally administered drug under ambulatory conditions].
abstract: The therapeutical effect of Defluina was studied in a selective open trial of 50 patients suffering from peripheral arterial occlusive diseases of different stages. All patients were treated with Defluina, 30 drops three times a day during a period of six weeks. Control parameters of 46 patients (18 males, 26 females, mean age of 59.8 +/- 1.7 years) were evaluated. After therapy a significant improvement of all applied parameters was observed. The positive effect of the Defluina-medication on the initial--partly severe--varicose ulcera, with gangrenous alterations, has to be pointed out. After 6 weeks the varicose ulcera were partly closed, at least they showed fresh granulations. During therapy no adverse reactions were registered. All patients estimated Defluina as very well tolerable. The therapeutic effect of Defluina on the carefully investigated group of 46 patients could be estimated in 38 cases with excellent/good, in 7 cases with good/moderate and only in 1 case with moderate.
mesh_terms: D000328:Adult; D000368:Aged; D001157:Arterial Occlusive Diseases / Q000188:drug therapy*; D048909:Diabetes Complications; D004087:Dihydroergotamine / Q000627:therapeutic use*; D004088:Dihydroergotoxine / Q000627:therapeutic use*; D004338:Drug Combinations; D004341:Drug Evaluation; D004879:Ergotamines; D005260:Female; D005734:Gangrene / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D007383:Intermittent Claudication / Q000188:drug therapy; D007871:Leg Ulcer / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D011674:Pulse / Q000187:drug effects; D015016:Yohimbine / Q000627:therapeutic use*
chemical_list: D004338:Drug Combinations; D004879:Ergotamines; D004088:Dihydroergotoxine; D015016:Yohimbine; D004087:Dihydroergotamine
vernacular_title: Zur Therapie der chronischen arteriellen Verschlusskrankheit Untersuchungen mit einem oral verabreichbaren Medikament unter ambulanten Bedingungen