The identification of 5beta,7alpha-dihydroxy-11-oxotetranor-prostane-1,16-dioic acid as a urinary metabolite of prostaglandin F2alpha in the rat.
5beta,7alpha-Dihydroxy-11-oxotetranor-prostane-1,16-dioic acid has been identified by gas chromatography-mass spectrometry as a urinary metabolite of [9beta-3H]prostaglandin F2alpha in the rat. This tetranor prostaglandin F derivative, which is the 5beta epimer of the major urinary metabolite of prostaglandin F2alpha, accounted for at least 2% of the total dose. Absence from the metabolite of tritium label at the C-5 position indicated the existence of a minor, previously unknown metabolic pathway by which prostaglandin Falpha derivatives may be converted by oxido-reduction into prostaglandins of Fbeta stereochemistry.
D000818:Animals; D002849:Chromatography, Gas; D005227:Fatty Acids / Q000652:urine*; D013058:Mass Spectrometry; D011460:Prostaglandins F / Q000652:urine*; D011466:Prostanoic Acids / Q000652:urine*; D051381:Rats
D005227:Fatty Acids; D011460:Prostaglandins F; D011466:Prostanoic Acids