Failure of growth hormone-suppressing agents to affect TSH-releasing hormone- and LH-releasing hormone-induced growth hormone release in acromegaly.
In patients with acromegaly whose basal plasma GH levels were suppressed with 9 mg/day of dexamethasone for 2 days, TRH-(6 cases) and LHRH-(1 case) induced GH release were unaffected when the responses were compared to the basal levels. Phentolamine infusion, 70 mg in 150 min, or hyperglycemia induced by iv infusion of 700 ml of 50% glucose solution also did not suppress TRH-induced GH release in 2 acromegalic patients whose basal GH levels were lowered with these agents alone. These results seem to indicate that dexamethasone does not affect TRH- or LHRH-induced GH release per se, but affects the basal state which determines the absolute level of response. They also support the concept that TRH and LHRH act directly on pituitary tumor cells to release GH in acromegaly.
D000172:Acromegaly / Q000097:blood* / Q000188:drug therapy; D003907:Dexamethasone / Q000627:therapeutic use; D005947:Glucose / Q000494:pharmacology; D007987:Gonadotropin-Releasing Hormone; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use; D010646:Phentolamine / Q000627:therapeutic use; D013973:Thyrotropin-Releasing Hormone
D007987:Gonadotropin-Releasing Hormone; D013973:Thyrotropin-Releasing Hormone; D003907:Dexamethasone; D013006:Growth Hormone; D005947:Glucose; D006854:Hydrocortisone; D010646:Phentolamine