[The propagation of aminoglycoside transferases in gram negative bacteria].
Molecular genetic and enzymatic studies on Gram-negative bacteria from hospital specimens give the following picture on surveillance of aminoglycoside transferases: The most frequent enzymes inactivate streptomycin only, AAD- (3'') and APH-(3''). Only 15% of the isolated enzymes inactivate gentamycin, tobramycin, sisomycin or amikacin. The most frequent of these are AAD-(2'') with 7% and AAC-(6') IV with 3%, both enzymes inactivate a wide range of substrates. The high frequency of streptomycin inactivating enzymes is due to the high incidence of linked resistance markers. A plasmid rPB1 is described, that is present in about 10% of all clinical isolates of E. coli. It has a molecular weight of 4. 1 Mdal and typical restriction pattern.
D000617:Aminoglycosides / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D001419:Bacteria / Q000201:enzymology*; D004352:Drug Resistance, Microbial; D011815:R Factors; D013379:Substrate Specificity; D014166:Transferases / Q000378:metabolism*
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D014166:Transferases
Die Ausbreitung von Aminoglykosid-Transferasen bei gramnegativen Bakterien.