Failure of luteinizing hormone-releasing hormone and insulin to further augment thyrotrophin release in primary hypothyroidism.
The effect of luteinizing hormone-releasing hormone (LH-RH) and insulin-induced hypoglycaemia on the release of thyrotrophin (TSH) was studied in five patients with primary hypothyroidism. All five patients had elevated TSH levels with an exaggerated rise in response to thyrotrophin-releasing hormone (TRH). No rise over control values was found after LH-RH or insulin indicating that despite the augmentation of TSH release in primary hypothyroidism there is no alteration of the specificity of the thyrotroph response.
D000328:Adult; D000368:Aged; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology*; D006801:Humans; D007037:Hypothyroidism / Q000503:physiopathology*; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D013972:Thyrotropin / Q000097:blood / Q000378:metabolism*; D013973:Thyrotropin-Releasing Hormone
D007328:Insulin; D007987:Gonadotropin-Releasing Hormone; D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin