title: [Effect of arginine ketoglutarate on the detoxifying capacity of the liver in cirrhosis of the liver (author's transl)].
abstract: According to the present studies it is shown that arginine ketoglutarate in sufficiently high dosage (3x3 g daily by mouth) produces a significant lowering of plasma ammonia and free serum phenols with a high-protein diet in patients with liver cirrhosis, compared to a previous day without this substance. The ammonia reduction can be explained by a significant increase in urea synthesis, measured by the urea nitrogen content of the 24-hour urine. The simultaneous lowering of pathologically raised serum levels of free phenols can be explained by an improved oxidative decomposition of these substances. No stimulation of insulin secretion worthy of note occurred after oral administration of 9 g arginine ketoglutarate.
mesh_terms: D000328:Adult; D000368:Aged; D000641:Ammonia / Q000097:blood; D001120:Arginine / Q000494:pharmacology*; D001711:Biotransformation / Q000187:drug effects; D001806:Blood Urea Nitrogen; D002940:Circadian Rhythm; D004044:Dietary Proteins; D005260:Female; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications / Q000378:metabolism; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008103:Liver Cirrhosis / Q000150:complications / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010636:Phenols / Q000097:blood; D014508:Urea / Q000096:biosynthesis / Q000652:urine
chemical_list: D004044:Dietary Proteins; D007328:Insulin; D010636:Phenols; D000641:Ammonia; D014508:Urea; D001120:Arginine
vernacular_title: Wirkung von Argininketoglutarat auf die Entgiftungsleistung der Leber bei Leberzirrhose