Glucagon release from rat pancreatic islets. A combined morphological and functional approach.
The release of glucagon induced in isolated rat islets by arginine or by calcium deprivation has been subjected to combined functional and morphological quantifications. Arginine-stimulated glucagon release was associated with a significant increase of morphological events linked to exocytosis. By contrast, the paradoxical events linked to exocytosis. By contrast, the paradoxical release of glucagon provoked by calcium deprivation, although accompanied by a significant loss of granule stores, was not associated with an increase of morphologically detectable exocytosis.
D000818:Animals; D001120:Arginine / Q000494:pharmacology; D002118:Calcium / Q000494:pharmacology; D005089:Exocytosis; D005614:Freeze Fracturing; D005934:Glucagon / Q000378:metabolism*; D005947:Glucose / Q000494:pharmacology; D005905:Glyburide / Q000494:pharmacology; D066298:In Vitro Techniques; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D008854:Microscopy, Electron; D051381:Rats
D005934:Glucagon; D001120:Arginine; D005947:Glucose; D005905:Glyburide; D002118:Calcium