Possible beta-lactamase activities detectable in infective clinical specimens.
Biological beta-lactam antibiotic-inactivating activities were detected in bacteriuria and suppurating pleural fluids. Clinical specimens were sterilized with membrane filters and the amounts of ampicillin and/or cephalothin which were being inactivated by 1 ml of each filtrate were determined. In general, filtrates which originally yielded Klebsiella sp. tended to show activity against ampicillin; whereas those yielding Enterobacter sp. and Pseudomonas aeruginosa showed activity against cephalothin.
D000581:Amidohydrolases / Q000378:metabolism*; D000667:Ampicillin / Q000037:antagonists & inhibitors; D001437:Bacteriuria / Q000201:enzymology* / Q000382:microbiology; D002510:Cephalosporinase / Q000378:metabolism*; D002512:Cephalothin / Q000037:antagonists & inhibitors; D004755:Enterobacteriaceae / Q000201:enzymology*; D010405:Penicillinase / Q000378:metabolism*; D010996:Pleural Effusion / Q000201:enzymology* / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000201:enzymology*; D013211:Staphylococcus aureus / Q000201:enzymology
D000667:Ampicillin; D000581:Amidohydrolases; D002510:Cephalosporinase; D010405:Penicillinase; D002512:Cephalothin