title: Baroreceptor and chemoreceptor responses to umbilical cord occlusion in fetal lambs.
abstract: 11 fetal lambs with gestational age of 116-135 days were studied while connected to a membrane-oxygenator replacing the ventilatory function of the placenta. Progressive increase in arterial oxygen tension from 20 to 220 mm Hg resulted in progressive decrease in baseline heart rate and baseline arterial blood pressure indicating presence of chemoreceptor activity over this wide range of arterial oxygen tension. The effect of 60 sec complete umbilical cord occlusion was studied at progressively higher arterial oxygen tension and it was concluded that the chemoreceptor activity at fetal normoxic condition is very brisk and is markedly attenuated at hyperoxic levels. Although it was not possible to completely separate baroreceptor and chemoreceptor reflexes involved in cardiovascular response to umbilical cord occlusion, it is postulated that the chemoreceptor and baroreceptor reflexes are complimentary during cardiovascular responses to umbilical cord occlusion.
mesh_terms: D000818:Animals; D001794:Blood Pressure; D002628:Chemoreceptor Cells / Q000502:physiology*; D005260:Female; D005333:Fetus / Q000502:physiology*; D005865:Gestational Age; D006339:Heart Rate; D010106:Oxygenators; D010313:Partial Pressure; D011247:Pregnancy; D011311:Pressoreceptors / Q000502:physiology*; D012756:Sheep; D014470:Umbilical Cord