Heterogeneity of prolactin and TSH response to TRH in hypotonadotropic hypogonadism.
To evaluate prolactin and TSH secretion in isolated gonadotropin deficiency, thyrotropin-releasing hormone (TRH), in a dose of 500 microgram, was administered iv to fifteen male subjects with this disorder. In 4 out of 8 untreated patients, TRH-mediated prolactin release was significantly blunted and this attenuated response was not improved in one patient after treatment with testosterone for 1 year. In 7 patients who were treated with testosterone for 2 to 8 years, four failed to show a normal prolactin response after TRH injection. TRH-induced TSH secretion, on the other hand, was attenuated in two out of 8 untreated and in two of 8 treated patients with hypogonadotropic hypogonadism. The decreased TSH reserve was not necessarily associated with the poor prolactin response to TRH. It was concluded that heterogeneity exists in TRH-mediated prolactin and TSH release in "isolated" gonadotropin deficiency syndrome.
D000293:Adolescent; D000328:Adult; D005640:Follicle Stimulating Hormone / Q000097:blood / Q000172:deficiency*; D006801:Humans; D007006:Hypogonadism / Q000097:blood* / Q000188:drug therapy; D007700:Kinetics; D007986:Luteinizing Hormone / Q000097:blood / Q000172:deficiency*; D008297:Male; D011388:Prolactin / Q000097:blood*; D013739:Testosterone / Q000627:therapeutic use; D013972:Thyrotropin / Q000097:blood*; D013973:Thyrotropin-Releasing Hormone
D013739:Testosterone; D013973:Thyrotropin-Releasing Hormone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin