Behavior of somatic cells homozygous for zygotic lethals in Drosophila melanogaster.
The behavior in genetic mosaics of 86 EMS-induced sex-linked lethals has been studied. Seventy-five percent of them are autonomous in gynandromorphs. Forty-three lethals nonviable in sex mosaics have been analyzed in X-ray-induced spots in the abdominal tergites and the imaginal wing derivatives. Of the lethals, 90.7% are homozygous viable in mosaic spots, and only 9.3% have been classified as epidermal cell lethal. Thus, the fraction of the Drosophila genome essential for cell viability has been estimated to be about 420 genes. The phenotypes at the cellular level of some cell-viable mutations altering cell parameters (mitotic orientation, differentiation, etc.) are described.
D000818:Animals; D002470:Cell Survival; D002999:Clone Cells; D004331:Drosophila melanogaster / Q000166:cytology* / Q000196:embryology; D005260:Female; D005804:Genes, Lethal; D006720:Homozygote; D008297:Male; D008938:Mitosis; D009024:Morphogenesis; D009030:Mosaicism; D010641:Phenotype; D012730:Sex Chromosomes; D014921:Wings, Animal / Q000196:embryology; D015053:Zygote