Electrophysiological effects soon after intravenous beta-methyldigoxin.
The digitalis derivative beta-methyldigoxin has been shown to be quickly and well absorbed from the gut and, in hemodynamic studies, to start acting rapidly after intravenous administration. However, when tested on 6 patients suffering from paroxysmal reciprocating atrioventricular tachycardia, or having an accessory pathway who might develop this disorder, there was no effect on induced tachycardias or on AV conduction during rapid atrial pacing or the extrastimulus test. One of the 6 patients showed some increase in refractoriness of conduction through the AV node within 25 min after the injection. Beta-methyldigoxin does not appear to be a satisfactory alternative to other effective agents available for the prompt correction of paroxysmal reciprocating atrioventricular tachycardia.
D000293:Adolescent; D000328:Adult; D002304:Cardiac Pacing, Artificial; D004077:Digoxin / Q000031:analogs & derivatives*; D004562:Electrocardiography; D004594:Electrophysiology; D006329:Heart Conduction System / Q000187:drug effects* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008520:Medigoxin / Q000494:pharmacology / Q000627:therapeutic use*; D008875:Middle Aged; D013614:Tachycardia, Paroxysmal / Q000188:drug therapy* / Q000503:physiopathology; D014927:Wolff-Parkinson-White Syndrome / Q000188:drug therapy* / Q000503:physiopathology
D004077:Digoxin; D008520:Medigoxin