title: Clinical pharmacology of tobramycin in infants.
abstract: Tobramycin was used in the treatment of severe infections in infants, mostly newborns and prematures. Serum half-life of the drug was 3.5 h in infants older than one week and above 2,500 g, and 8.0 h in infants below one week and less than 2,500 g. Apparent volume of distribution was similar in both groups, 0.24 l/kg. Intravenous infusions of the drug gave considerably higher plasma levels than intramuscular infections. Particularly in the newborn and premature group intramuscular injections gave fairly unpredictable plasma concentrations.
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy*; D001835:Body Weight; D002675:Child, Preschool; D004341:Drug Evaluation; D006207:Half-Life; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000188:drug therapy; D007235:Infant, Premature, Diseases / Q000188:drug therapy; D014031:Tobramycin / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D014031:Tobramycin