Experimental production of arachnoiditis with water-soluble myelographic media.
After myelography with either metrizamide (300mg l/ml) or meglumine iocarmate (280 mg l/ml), mild to severe arachnoid fibrosis was demonstrated radiographically and histologically in primates. Intrathecal injections of metrizamide (170 mg l/ml) or autologous cerebrospinal fluid produced less arachnoiditis. The risk of arachnoiditis is probably minimized by the use of reduced volumes and concentrations of water-soluble media. Controlled studies of arachnoiditis following myelography are probably more reliable in the primate model  than in other experimental animals.
D000818:Animals; D001100:Arachnoiditis / Q000139:chemically induced* / Q000473:pathology; D004195:Disease Models, Animal; D000882:Haplorhini; D007463:Iodobenzoates; D007482:Iothalamate Meglumine; D007483:Iothalamic Acid / Q000031:analogs & derivatives; D008251:Macaca; D008793:Metrizamide; D009192:Myelography; D012995:Solubility; D014867:Water
D007463:Iodobenzoates; D014867:Water; D007483:Iothalamic Acid; D008793:Metrizamide; D007482:Iothalamate Meglumine