title: Aurintricarboxylic acid (ATA) and DNA synthesis. II. Effect of ATA on structure and function of the crypts of the small intestine.
abstract: ATA affects only slightly DNA synthesis of continuously replicating cells. A single injection of the drug reduces the incorporation of (3H)-thymidine into DNA of crypt cells to only 62% of the control. The effect on DNA synthesis is preceded by a slight inhibition of protein synthesis, and by a partial decrease in the number of dividing cells. On the contrary, the incorporation of (3H)-uridine into RNA was enhanced. Electron microscopic studies revealed no cytologic abnormalities in ATA-treated animals. In view of the fact that ATA at the same concentration inhibits DNA synthesis of growth stimulated cells to 100% (Novi, 1976), it was suggested that the drug may become an useful tool in inducing a preferential inhibition of growth stimulation.
mesh_terms: D000818:Animals; D001312:Aurintricarboxylic Acid / Q000494:pharmacology*; D003509:Cyclohexanecarboxylic Acids / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis*; D005260:Female; D007413:Intestinal Mucosa / Q000378:metabolism / Q000648:ultrastructure; D051379:Mice; D008854:Microscopy, Electron; D008938:Mitosis / Q000187:drug effects; D012313:RNA / Q000096:biosynthesis; D012269:Ribosomal Proteins / Q000096:biosynthesis
chemical_list: D003509:Cyclohexanecarboxylic Acids; D012269:Ribosomal Proteins; D001312:Aurintricarboxylic Acid; D012313:RNA; D004247:DNA