title: Experimental allergic sialoadenitis. X. Chronic destructive parotitis induced in immunized rats by daily intraductal challenges with antigen.
abstract: The right parotid duct of rats was instilled five to eight times with bovine serum albumin at daily intervals. Acute parotitis developed in non-sensitized animals, while chronic destructive sialoadenitis ensued in preimmunized rats. The morphological changes were reminiscent of those found in the salivary glands of patients with Sjögren's syndrome.
mesh_terms: D000208:Acute Disease; D000818:Animals; D002908:Chronic Disease; D005260:Female; D006967:Hypersensitivity / Q000473:pathology; D007114:Immunization; D008297:Male; D010306:Parotid Gland / Q000276:immunology*; D010309:Parotitis / Q000276:immunology* / Q000473:pathology; D051381:Rats; D012466:Salivary Gland Diseases / Q000276:immunology*; D012710:Serum Albumin, Bovine; D012793:Sialadenitis / Q000209:etiology / Q000276:immunology* / Q000473:pathology
chemical_list: D012710:Serum Albumin, Bovine