Inhibition of protein synthesis in ischaemic liver from phenobarbitone-treated rat.
Both ribosomal factors and cytosolic inhibitors are involved in the reduction of the rate of protein synthesis which occurs in the ischaemic hepatocyte from control and phenobarbitone-treated livers. Of these 2 factors it is the latter which seems to play a major role in determining the irreversible impairment of protein synthesis. Phenobarbitone administration has no effect on the rate of protein synthesis of ischaemic and post-ischaemic hepatocyte.
D000818:Animals; D003600:Cytosol / Q000378:metabolism; D007511:Ischemia / Q000378:metabolism*; D008099:Liver / Q000098:blood supply* / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010634:Phenobarbital / Q000494:pharmacology*; D014176:Protein Biosynthesis; D051381:Rats; D012270:Ribosomes / Q000378:metabolism
D010634:Phenobarbital