[Anthracycline antibiotic, beromycin. The formation of complexes with DNA and the suppresion of nucleic acid biosynthesis].
Beromycin, an antitumor anthracycline antibiotic formed in vitro complexes with native and denaturated DNA and ribosomal RNA. Beromycin had a comparatively low constant of DNA binding and to a less extent increased the melting temperature and viscosity of DNA than the other anthracycline antibiotics. A peculiar property of beromycin was very slow binding with DNA, the complex formation was completed in 60 minutes. Beromycin had a selective inhibitory effect on synthesis of nucleic acids in bacterial and tumor cells. Beromycin inhibited synthesis of RNA in the DNA-dependent RNA-polymerase reaction when both the native and denaturated DNA were used as the template. A lower biological activity of beromycin as compared to the other anthracycline antibiotics, such as rubomycin or carminomycin may be explained by lower affinity of this antibiotic to DNA.
D000818:Animals; D004247:DNA / Q000037:antagonists & inhibitors; D004269:DNA, Bacterial / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004273:DNA, Neoplasm / Q000037:antagonists & inhibitors; D003630:Daunorubicin / Q000494:pharmacology; D004926:Escherichia coli; D007700:Kinetics; D008223:Lymphoma / Q000188:drug therapy; D051379:Mice; D008837:Micrococcus; D009374:Neoplasms, Experimental / Q000188:drug therapy; D010404:Penicillin V / Q000494:pharmacology*; D011119:Polynucleotides / Q000494:pharmacology; D011485:Protein Binding / Q000187:drug effects; D012313:RNA / Q000037:antagonists & inhibitors*; D012329:RNA, Bacterial / Q000037:antagonists & inhibitors; D012334:RNA, Neoplasm / Q000037:antagonists & inhibitors
D004269:DNA, Bacterial; D004273:DNA, Neoplasm; D011119:Polynucleotides; D012329:RNA, Bacterial; D012334:RNA, Neoplasm; D012313:RNA; D004247:DNA; D010404:Penicillin V; D003630:Daunorubicin
Antratsiklinovyĭ antibiotik beromitsin. Obrazovanie kompleksov s DNK i podavlenie biosinteza nukleinovykh kislot.