[Antiandrogenic effects of 4-nitro-3-trifluoromethylisobutyrylanilide (niftolide) in prepubertal male rats during stimulation with exogenous gonadotropins].
Nonsteroid antiandrogen 4-nitro-3-trifluoromethylisobutyranilide (10 mg/kg per os from the 26th to the 37th day after birth) decreased the weight of the accessory sex organs, and levator ani muscle. DNA, RNA, and protein content in the ventral prostate and the seminal vesicles, the thickness of the secretory cell epithelium of the ventral prostate under conditions of stimulation of prepubertal male rat gonads with human gonadotropin (100 Units/kg subcutaneously from the 21st to the 37th day after birth). The mentioned effects were observed against the background of hyperplasia and hypertrophy of Leidig's cells and increase of the activity of steroid-delta5-3beta-ol-dehydrogenase of the testes activity. A conclusion was made that niftolide was capable of preventing or delaying the development of some signs of premature sexual maturation.
D015096:3-Hydroxysteroid Dehydrogenases / Q000378:metabolism; D000726:Androgen Antagonists; D000813:Anilides / Q000008:administration & dosage*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D006063:Chorionic Gonadotropin / Q000008:administration & dosage*; D004247:DNA / Q000032:analysis; D005485:Flutamide / Q000008:administration & dosage*; D005837:Genitalia, Male / Q000187:drug effects*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011467:Prostate / Q000032:analysis; D011506:Proteins / Q000032:analysis; D012313:RNA / Q000032:analysis; D051381:Rats; D012669:Seminal Vesicles / Q000032:analysis; D012741:Sexual Maturation / Q000187:drug effects*; D013737:Testis / Q000201:enzymology
D000726:Androgen Antagonists; D000813:Anilides; D006063:Chorionic Gonadotropin; D011506:Proteins; D012313:RNA; D005485:Flutamide; D004247:DNA; D015096:3-Hydroxysteroid Dehydrogenases
Antiandrogennye éffekty 4-nitro-3-triftormetilizobutiranilida (niftolida) u samtsov krys prepubertatnogo vozrasta v usloviiakh ékzogennoĭ gonadotropnoĭ stimuliatsii.