title: Epidemiological and serological study of scrub typhus among Chinese military in the Pescadores islands of Taiwan.
abstract: An outbreak of 69 cases of scrub typhus occurred among Chinese military personnel stationed in the Pescadores Islands, Taiwan Province, Republic of China between May and November 1975. A retrospective epidemiological study of this outbreak indicated that military personnel over 40 were more likely to have scrub typhus than those under 40. High risk groups included the Garrison Force (home guard), anti-aircraft gunners and infantry and armoured units stationed at Hsing-jen. The onset of symptoms in 69% occurred within one year of residence in the Pescadores. The clinical course of scrub typhus and the serological response to infection were also studied. Eschar formation, fever, headache chills and lymph node enlargement were the predominant clinical manifestations noted. The indirect immunofluorescent antibody test (IFAT) demonstrated diagnostic (four-fold) rises in antibody titres to Rickettsia tsutsugamushi reference strains in 36 of 41 paired sera tested. 11 of 19 patients from whom only single sera were obtained had IFA titres presumptive of scrub typhus (greater than or equal to 1:160). Of 19 patients experiencing possible primary infections, 13 (68%) responded with antibodies directed against more than one reference strain of R. tsutsugamushi. These results suggest that several antigenically diverse strains of R. tsutsugamushi may be active in the Pescadores.
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D002681:China / Q000208:ethnology; D006801:Humans; D008297:Male; D051379:Mice; D008889:Military Personnel; D012285:Orientia tsutsugamushi / Q000276:immunology*; D012612:Scrub Typhus / Q000453:epidemiology* / Q000276:immunology; D013624:Taiwan
chemical_list: D000907:Antibodies, Bacterial