The metabolism of ftorafur in the beagle dog and rhesus monkey.
1. Ftorafur, a fluorinated pyrimidine nucleoside antimetabolite, is metabolized by the beagle dog and rhesus monkey to 5-fluorouracil, which is subsequently biotransformed to the corresponding nucleosides, to alpha-fluoro-beta-ureidopropionic acid, to urea and to CO2. 2. In the dog, urea was the primary urinary metabolite while in the monkey, alpha-fluoro-beta-ureidopropionic acid predominated. 3. The dog and monkey excrete about 35 percent of the recovered dose as CO2. 4. The possibility that ftorafur is a relatively inactive transport form of 5-fluorouracil is discussed.
D000818:Animals; D001711:Biotransformation; D004285:Dogs; D005472:Fluorouracil / Q000031:analogs & derivatives*; D000882:Haplorhini; D008253:Macaca mulatta; D008297:Male; D005641:Tegafur / Q000097:blood / Q000378:metabolism* / Q000652:urine; D013997:Time Factors
D005641:Tegafur; D005472:Fluorouracil