The effect of tablet formulation on the haemodynamic properties of glyceryl trinitrate.
A non-invasive haemodynamic study was carried out in 13 normal subjects to compare the pharmacodynamics of glyceryl trinitrate when formulated as a moulded tablet ('Nitrostat') rather than as a generic compressed tablet. The glyceryl trinitrate moulded tablet, with a much more rapid and predictable dissolution time, produced an earlier onset of systolic blood pressure fall (p less than 0.01) and a greater maximum percentage change in peripheral blood flow (p less than 0.02). No other significant differences in effect on pulse rate, blood pressure or peripheral blood flow were noted.
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D004355:Drug Stability; D005260:Female; D005542:Forearm / Q000098:blood supply; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D005996:Nitroglycerin / Q000008:administration & dosage* / Q000494:pharmacology; D010919:Placebos; D011674:Pulse / Q000187:drug effects; D012039:Regional Blood Flow / Q000187:drug effects; D013607:Tablets
D010919:Placebos; D013607:Tablets; D005996:Nitroglycerin