["In vitro" activity of gentamicin, sisomicin and tobramycin against "pseudomonas aeruginosa" strains from hospital sources (author's transl)].
The in vitro activity of two amynoglicosidic antibiotics, tobramycin and sisomicin, against 215 strains of Pseudomonas aeruginosa isolated from clinical specimens during the years 1972-1975, was evaluated in comparison with that of gentamicin. Tobramycin showed a greater activity than sisomicin and gentamicin. At the concentration of 5 mu/ml tobramycin resulted inhibitory on 94% of strains and sisomicin and gentamicin on 78.6% and 49.8% of strains respectively. The susceptibility of Pseudomonas aeruginosa strains to gentamicin decreased from 1972 to 1975, with an increasing of resistant strains of 23%. In an evaluation of possible cross-resistance of 14 strains of Pseudomonas aeruginosa highly resistant (MIC greater than or equal to 25 gamma/ml) to gentamicin, 13 showed a high degree of resistance also to sisomicin; on the other hand 7 strains highly resistant to gentamicin was sensitive to tobramycin at concentration less than or equal to 10 gamma/ml.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002648:Child; D003428:Cross Infection / Q000382:microbiology*; D004352:Drug Resistance, Microbial; D005839:Gentamicins / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D012853:Sisomicin / Q000494:pharmacology*; D014031:Tobramycin / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D014031:Tobramycin; D012853:Sisomicin
Attivita "in vitro" di gentamicina, sisomicina e tobramicina su stipiti di "Pseudomonas aeruginosa" di provenienza ospedaliera.