Immunological studies with aortic and venous tissue antigens. III. Examination of cell-mediated and humoral immune response induced by human vascular antigens.
The effects of human vascular antigens on the cell-mediated and the humoral immune response were studied in guinea pigs. In animals immunized with buffer extracts of aortic and venous wall a well measurable cell-mediated and humoral immune response were developed. Between the two kinds of vascular extracts in the skin tests, migration inhibition tests and antibody-production tests a cross-reactivity was observed, whereas the induction of desoxyribonucleic acid-synthesis proved to be specific. No cellular or humoral immune response to vascular extracts was detectable in the control animals. Analysing the time-kinetics of the cell-mediated and humoral immune response it was found, that with the increased production of antibodies the cellular immune reactions did not cease until the ninth week.
D000818:Animals; D000917:Antibody Formation; D000941:Antigens; D001011:Aorta / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis; D001324:Autoantigens; D001808:Blood Vessels / Q000276:immunology*; D002464:Cell Migration Inhibition; D003429:Cross Reactions; D005260:Female; D006168:Guinea Pigs; D006386:Hemagglutination Tests; D006801:Humans; D007111:Immunity, Cellular; D005779:Immunodiffusion; D007962:Leukocytes / Q000276:immunology; D008297:Male; D012882:Skin Tests; D013997:Time Factors; D014680:Veins / Q000276:immunology
D000941:Antigens; D001323:Autoantibodies; D001324:Autoantigens