title: The rate of action of cyclic ammonium and sulfonium analogues of acetylcholine.
abstract: The rate of action of cyclic acetylcholine analogues in the 4-acetoxypiperidine and 4-acetoxythiacyclohexane series has been determined by using the isolated left guinea-pig atrium. The kinetic data obtained has been correlated with the experimental ED50-value on the muscarinic receptor.
mesh_terms: D000109:Acetylcholine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D003510:Cyclohexanes / Q000494:pharmacology*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008968:Molecular Conformation; D009200:Myocardial Contraction / Q000187:drug effects; D009861:Onium Compounds / Q000494:pharmacology*; D010880:Piperidines / Q000494:pharmacology*; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*; D011950:Receptors, Cholinergic / Q000187:drug effects*; D011976:Receptors, Muscarinic / Q000187:drug effects*; D013329:Structure-Activity Relationship; D013452:Sulfonium Compounds / Q000494:pharmacology*
chemical_list: D003510:Cyclohexanes; D009861:Onium Compounds; D010880:Piperidines; D000644:Quaternary Ammonium Compounds; D011950:Receptors, Cholinergic; D011976:Receptors, Muscarinic; D013452:Sulfonium Compounds; D000109:Acetylcholine