[Ca++-dependent immunosuppressive effect of ethylenediaminetetraacetic acid (EDTA)].
Subcutaneous injection of a sum total dose of 6.44.10(-5) M of ethylenediaminetetraacetic acid (EDTA), which binds divalent cations, inhibits the process of accumulation of antibody-forming cells in the spleen of mice (CBA X C57BL) F1 hybrids, immunizated with sheep red blood cells. In a dose of 5.2.10(-5) M CaCl2 eliminated the immunodepressive effect of EDTA almost completely. It was assumed that EDTA action was produced through the Ca++-controlled regulation mechanism of one of the following processes:  the interaction between T- and B-lymphocytes; proliferation and differentiation of T- and B-cells in the course of the immune response to sheep red blood cells. A more complex mechanism of EDTA action on the above-mentioned processes is not excluded, however.
D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects*; D001402:B-Lymphocytes / Q000166:cytology / Q000187:drug effects; D002122:Calcium Chloride / Q000494:pharmacology*; D002452:Cell Count; D002455:Cell Division / Q000187:drug effects; D003864:Depression, Chemical; D004336:Drug Antagonism; D004492:Edetic Acid / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D007166:Immunosuppressive Agents; D051379:Mice; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects
D007166:Immunosuppressive Agents; D004492:Edetic Acid; D002122:Calcium Chloride
Ca++-zavisimyĭ immunodepressivnyĭ (effekt) etilendiamintetrauksusnoĭ kisloty (EDTA).