Some properties of monoclonal cryoglobulin M appearing in the course of malignant lymphoma with macroglobulinemia.
Monoclonal cryoglobulin IgM was separated from the serum of a patient with malignant lymphoma and macroglobulinemia. The purified cryoglobulin in immunoelectrophoresis formed the precipitin lines with anti-mu and anti-kappa serum and showed an abnormal electrophoretic mobility due to large aggregate formation. In comparison to normal IgM preparations a significantly lower content of hydroxyproline was found in the cryoglobulin studied. The possible role of hydroxyproline-containing peptides in the formation of the oligomeric structure of the IgM molecule is discussed.
D003450:Cryoglobulins / Q000302:isolation & purification / Q000378:metabolism; D006801:Humans; D007122:Immunoelectrophoresis; D007075:Immunoglobulin M / Q000378:metabolism; D008223:Lymphoma / Q000097:blood* / Q000150:complications; D008258:Waldenstrom Macroglobulinemia / Q000097:blood* / Q000150:complications
D003450:Cryoglobulins; D007075:Immunoglobulin M