Induction of hapten-specific cell-mediated immunity in rhesus monkeys treated with adsorbent purified antilymphocyte antibody.
Rhesus monkeys were treated with sufficient amounts of rabbit antilymphocyte sera and immunoadsorbent purified antilymphocyte antibody to retain full-thickness skin grafts 23 and 29 days respectively. During this immunosuppressed period hapten-specific cell-mediated immunity was induced in six of seven rhesus monkeys immunized with p-azophenylarsono-N-acetyltyrosine (R-tyr) in complete Freund's adjuvant. These observations suggest that in rhesus monkeys different populations of T cells may be responsible for cutaneous sensitization to antigen and rejection of skin grafts.
D000818:Animals; D000936:Antigen-Antibody Complex; D000961:Antilymphocyte Serum / Q000494:pharmacology*; D002417:Cattle; D000882:Haplorhini; D006241:Haptens; D007111:Immunity, Cellular; D007164:Immunosorbents; D008213:Lymphocyte Activation; D008253:Macaca mulatta; D011817:Rabbits; D012710:Serum Albumin, Bovine / Q000276:immunology; D014373:Tuberculin; D014443:Tyrosine / Q000276:immunology
D000936:Antigen-Antibody Complex; D000961:Antilymphocyte Serum; D006241:Haptens; D007164:Immunosorbents; D014373:Tuberculin; D012710:Serum Albumin, Bovine; D014443:Tyrosine