Effect of anti-mu-chain-specific immunosuppression on Chikungunya virus encephalitis of mice.
Mice neonatally immunosuppressed with anti-mu antiserum failed to produce circulating antibodies to sheep erythrocytes and showed a marked decrease in circulating immunoglobulins. However, when they were intracerebrally infected with Chikungunya virus (a group A togavirus), they showed a mortality rate consistently lower than non-immunosuppressed control mice. Several possible explanations for this finding are discussed.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000008:administration & dosage*; D000914:Antibodies, Viral / Q000096:biosynthesis; D002646:Chikungunya virus; D004671:Encephalitis, Arbovirus / Q000276:immunology* / Q000401:mortality; D005260:Female; D007143:Immunoglobulin Heavy Chains; D007148:Immunoglobulin mu-Chains; D007165:Immunosuppression Therapy; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C
D000888:Antibodies, Anti-Idiotypic; D000914:Antibodies, Viral; D007143:Immunoglobulin Heavy Chains; D007148:Immunoglobulin mu-Chains