[Immunochemical study of serum in the diagnosis of mu-chain disease].
An abnormal protein revealed in the serum of a patient with an unknown lymphoproliferative disorder proved to be micron-paraprotein: micron-heavy chain complexes of various molecular weight totally lacking light chains. The results of immunochemical analysis of this case are compared with the published data on micron-chain disease. The following immunochemical features typical for micron-chain disease were observed in this patient: anodal mobility of paraprotein, failure to reveal it by serum electrophoresis, that is, absence of M-gradient, and presence of Bence Jones protein, type x in the urine and the serum. The peculiarity of the case consists in a high tendency of free x-chains to form complexes, and therefore in their marked electrophoretic heterogeneity giving a false impresssion of the ability of micron-paraprotein to react with the anti-x serum, thus complicating the diagnosis. Possible causes of a defect in the IgM assembly are discussed.
D001536:Bence Jones Protein / Q000652:urine; D055598:Chemical Phenomena; D002621:Chemistry; D002850:Chromatography, Gel; D002852:Chromatography, Ion Exchange; D005260:Female; D006362:Heavy Chain Disease / Q000175:diagnosis / Q000276:immunology*; D006801:Humans; D005779:Immunodiffusion; D007122:Immunoelectrophoresis; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007143:Immunoglobulin Heavy Chains / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis; D007148:Immunoglobulin mu-Chains / Q000032:analysis* / Q000302:isolation & purification; D007163:Immunosorbent Techniques
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007143:Immunoglobulin Heavy Chains; D007075:Immunoglobulin M; D007148:Immunoglobulin mu-Chains; D001536:Bence Jones Protein
Immunokhimicheskoe issledovanie syvorotki v diagnostike bolezni mu-tsepeĭ