Cardiac dysfunction in a patient with familial hypokalemic periodic paralysis.
A 19-year-old white man with familial hypokalemic periodic paralysis developed evidence of cardiac dysfunction during a episode of flaccid paralysis. This consisted of elevated total creatine phosphokinase (CPK), an increased myocardial fraction of CPK (myocardial band), alteration in the lactic dehydrogenase isoenzyme pattern, severe bradycardia, and evidence of left ventricular dysfunction. These findings, in conjunction with selected cases from the literature, suggest the possibility that cardiomyopathy may be a heretofore unrecognized complication of this disorder.
D000328:Adult; D001919:Bradycardia / Q000209:etiology; D009202:Cardiomyopathies / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D003402:Creatine Kinase / Q000097:blood; D004452:Echocardiography; D004562:Electrocardiography; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D007008:Hypokalemia / Q000150:complications* / Q000503:physiopathology; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D008943:Mitral Valve / Q000503:physiopathology; D009200:Myocardial Contraction; D010245:Paralyses, Familial Periodic / Q000150:complications* / Q000503:physiopathology; D010701:Phonocardiography; D011674:Pulse; D013599:Systole
D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase