title: Production of endogenous D-glucaric acid and oxidative N-demethylation of amidopyrine in man: lack of correlation.
abstract: In adult male subjects there was no positive correlation between the 24-hr urinary excretion of D-glucaric acid (D-GA) and the metabolic formation of 4-aminoantipyrine (AAP) from amidopyrine. It is concluded that in man the urinary D-GA excretion rate cannot be regarded in general as an indirect measure of the activity of microsomal drug conversion by means of mixed-function oxidases (MFO). Normal urinary value for D-GA: 16.3 +/- 1.5 (mean +/- SEM) mumols saccharo-1,4-lactone/24 hr as equivalent.
mesh_terms: D000328:Adult; D000632:Aminopyrine / Q000378:metabolism*; D000633:Aminopyrine N-Demethylase / Q000378:metabolism; D003640:Dealkylation; D005937:Glucaric Acid / Q000378:metabolism* / Q000652:urine; D006801:Humans; D008297:Male; D010084:Oxidation-Reduction; D013400:Sugar Acids / Q000378:metabolism*; D013997:Time Factors
chemical_list: D013400:Sugar Acids; D000632:Aminopyrine; D000633:Aminopyrine N-Demethylase; D005937:Glucaric Acid