Different types of beta-thalassemia intermedia. A genetic study in 20 patients.
20 patients with beta-thalassemia intermedia classified according to the results of genetic studies are presented. (1) 9 patients with beta-thalassemia intermedia homozygous for beta-thalassemia with increased Hb-A2 are reported. (2) 8 patients with beta-thalassemia intermedia, 3 homozygous for beta-thalassemia with normal levels of Hbs.A2 and F, 5 heterozygous for both this and beta-thalassemia with increased Hb-A2 are presented. (3) 2 families with beta-thalassemia intermedia heterozygous for both beta-thalassemia with increased HbA2 and 'silent" beta-thalassemia are reported. Two different varieties are presented.
D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D014644:Genetic Variation; D006441:Hemoglobin A / Q000032:analysis; D006455:Hemoglobins, Abnormal / Q000032:analysis; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D013789:Thalassemia / Q000235:genetics*
D006455:Hemoglobins, Abnormal; D006441:Hemoglobin A