Tissue persistence of gentamicin in man.
A two-compartment pharmcokinetic model was used to caracterize serum concentrations and to predict tissue accumulation of gentamicin in 47 treated patients. Postmortem tissues were obtained in six cases; in each instance, tissues yielded the predicted amount of drug. Slow release of tissue-bound gentamicin accounts for its prolonged retention in the body. The two-compartment model adequately predicts gentamicin accumulation from serum concentrations and explains why this antibiotic persists in serum and urine.
D000328:Adult; D000368:Aged; D001412:Bacillus subtilis / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D001681:Biological Assay; D005839:Gentamicins / Q000097:blood / Q000378:metabolism* / Q000627:therapeutic use; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008875:Middle Aged
D005839:Gentamicins