A potent antinociceptive cannabinoid which lacks opiate substitution properties in monkeys.
(-)-9-Nor-9beta-hydroxy-hexahydrocannabinol[(-)-9-nor-9beta-OH-HHC] produced hypotension and bradycardia in anesthetized dogs, was a potent antinociceptive agent in the mouse tail-flick and p-phenylquinone abdominal-stretching tests, but did not reverse the effects of morphine withdrawal in dependent monkeys.
D000700:Analgesics; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002186:Cannabinoids / Q000494:pharmacology*; D004285:Dogs; D013759:Dronabinol / Q000494:pharmacology; D000882:Haplorhini; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D051379:Mice; D009020:Morphine / Q000494:pharmacology; D011930:Reaction Time / Q000187:drug effects; D013237:Stereoisomerism; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology*
D000700:Analgesics; D002186:Cannabinoids; D009020:Morphine; D013759:Dronabinol