title: Methotrexate analogues. 8. Synthesis and biological evaluation of bisamide derivatives as potential prodrugs.
mesh_terms: D000577:Amides / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology; D002478:Cells, Cultured; D002855:Chromatography, Thin Layer; D005493:Folic Acid Antagonists; D006801:Humans; D007780:Lacticaseibacillus casei / Q000201:enzymology; D007939:Leukemia L1210 / Q000378:metabolism; D007942:Leukemia, Experimental / Q000378:metabolism; D007945:Leukemia, Lymphoid / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008727:Methotrexate / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology; D051379:Mice; D051381:Rats
chemical_list: D000577:Amides; D000970:Antineoplastic Agents; D005493:Folic Acid Antagonists; D008727:Methotrexate