title: Prophylactic chelation therapy in occupational lead poisoning: a review.
abstract: Chelating agents are useful in the therapy of acute overexposure to lead. However, prophylactic use of chelating agents, particularly under conditions of continued exposure to lead can be harmful to health. Potential adverse effects include kidney damage, symptomatic lead poisoning, increased absorption of lead from the gastrointestinal tract and disruption in the metabolism of trace metals other than lead. Prophylactic chelation is an unacceptable medical practice which cannot be condoned.
mesh_terms: D000328:Adult; D000818:Animals; D002648:Child; D004357:Drug Synergism; D004492:Edetic Acid / Q000009:adverse effects / Q000627:therapeutic use*; D005243:Feces / Q000032:analysis; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects; D007854:Lead / Q000378:metabolism; D007855:Lead Poisoning / Q000188:drug therapy* / Q000378:metabolism / Q000517:prevention & control; D008297:Male; D009784:Occupational Diseases / Q000139:chemically induced*
chemical_list: D007854:Lead; D004492:Edetic Acid