Swine influenza virus vaccine: potentiation of antibody responses in rhesus monkeys.
Polyriboinosinic-polyribocytidylic acid stabilized with poly-L-lysine and carboxymethylcellulose [poly(ICLC)] enhances the antibody response in rhesus monkeys immunized with swine influenza virus subunit vaccine. Monkeys given the vaccine-adjuvant combination had earlier and significantly (P less than .05) higher titers by 14 days compared to those that received vaccine alone. The potentiation of the antibody response of young monkeys given a split-virus vaccine in combination with poly(ICLC) suggests that this vaccine-adjuvant combination may similarly provide a potentially useful alternative approach to the immunization of pediatric and young adult age groups against swine influenza.
D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000009:adverse effects; D000367:Age Factors; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D002266:Carboxymethylcellulose Sodium; D005260:Female; D005334:Fever / Q000139:chemically induced; D000882:Haplorhini; D009980:Influenza A virus / Q000276:immunology*; D007252:Influenza Vaccines / Q000008:administration & dosage; D008253:Macaca mulatta; D008297:Male; D010455:Peptides / Q000276:immunology; D011070:Poly I-C / Q000276:immunology
D000276:Adjuvants, Immunologic; D000914:Antibodies, Viral; D007252:Influenza Vaccines; D010455:Peptides; D002266:Carboxymethylcellulose Sodium; D011070:Poly I-C