Silicosis and tuberculosis.
Two subjects had silicosis complicated by tuberculosis. In both patients, there was a relapse of the tuberculosis after chemotherapy was discontinued, in one case after 13 years of therapy with isoniazid and p-aminosalicylic acid. It would appear that the risk of tuberculosis in subjects with silicosis persists for life, and the suggestion is made that chemotherapy should be continued indefinitely.
D000328:Adult; D010131:Aminosalicylic Acid / Q000008:administration & dosage / Q000627:therapeutic use; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004977:Ethambutol / Q000008:administration & dosage / Q000627:therapeutic use; D005000:Ethionamide / Q000627:therapeutic use; D006801:Humans; D007538:Isoniazid / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011718:Pyrazinamide / Q000627:therapeutic use; D011859:Radiography; D012008:Recurrence; D012830:Silicotuberculosis / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D013307:Streptomycin / Q000627:therapeutic use; D013997:Time Factors
D000995:Antitubercular Agents; D011718:Pyrazinamide; D010131:Aminosalicylic Acid; D004977:Ethambutol; D005000:Ethionamide; D007538:Isoniazid; D013307:Streptomycin