Autologous bone marrow transplantation in patients with cancer.
Ten patients with non-leukemic neoplasms received intensive, marrow-lethal doses of drugs and radiation followed by rescue with autologous cryopreserved bone marrow (nine) or marrow from an identical twin as part of a phase 1-2 study. Nine patients had extensive disease that was unresponsive to conventional therapy. Marrow engraftment was documented in all evaluable cases and most patients had a substantial anti-tumor response. Three patients are alive from 4 to 10 months following transplantation without evidence of disease.
D016026:Bone Marrow Transplantation; D005615:Freezing; D006801:Humans; D007109:Immunity; D009369:Neoplasms / Q000628:therapy*; D011309:Preservation, Biological