Cross-idiotypic reactions among anti-Rh (D) antibodies.
In a series of experiments several idiotype-specific rabbit antisera produced against different IgG anti-Rh (D) antibodies reacted with other anti-Rh (D) antibodies and thus showed cross-idiotypic reactions. Some of the antisera agglutinated almost all types of anti-D-sensitized erythrocytes, whereas other idiotype-specific antisera agglutinated only a few anti-D-sensitized erythrocytes. Anti-D-antibodies showed several different cross-idiotypic reaction patterns. The cross-idiotypic antigens were, in most instances, localized to the heavy chains only. In a few cases, however, the cross-idiotypic antigens were dependent on the interaction between heavy and light chains.
D003429:Cross Reactions; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007106:Immune Sera; D007074:Immunoglobulin G; D007143:Immunoglobulin Heavy Chains; D007147:Immunoglobulin Light Chains; D007518:Isoantibodies; D011247:Pregnancy; D012204:Rh-Hr Blood-Group System
D007106:Immune Sera; D007074:Immunoglobulin G; D007143:Immunoglobulin Heavy Chains; D007147:Immunoglobulin Light Chains; D007518:Isoantibodies; D012204:Rh-Hr Blood-Group System