title: Adaptation of a single injection clearance method to physiological and pathophysiological facts. A review of data obtained in infancy and childhood.
abstract: A retrospective analysis of 395 51Chromiumethylenediaminotetraacetate single injection clearances performed in infants and children is presented. In 61% of infants and 30% of the children the clearance values were calculated on the basis of a plasma disappearance half time of the reference substance, which was longer than the standard study, i.e. on the basis of extrapolated data. Plasma creatinine and urea levels were found to be appropriate indicators for predicting the plasma disappearance half time of the marker substance. 14 additional patients were studied prospectively with a duration of the study predicted by means of the plasma creatinine and urea levels.  In these patients, separate determinations of the clearances using either the data obtained during the standard time of procedure only, or the data of the entire study, clearly demonstrated that the clearances obtained by means of the standard procedure overestimated glomerular filtration rate. The analysis of the data in infants show that the plasma urea level is a reasonably good indicator for predicting the time schedule of the study whereas plasma creatinine should not be used. Additionally the retrospective data indicate that a prolongation of the study should be recommended in all infants. This study demonstrates the necessity and offers means of adapting the time schedule of isotope single injection clearances to physiological and pathophysiological facts.
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002860:Chromium Radioisotopes; D003404:Creatinine / Q000097:blood; D004492:Edetic Acid / Q000097:blood; D005919:Glomerular Filtration Rate; D006207:Half-Life; D006801:Humans; D007223:Infant; D007674:Kidney Diseases / Q000175:diagnosis*; D008657:Metabolic Clearance Rate; D011446:Prospective Studies; D012189:Retrospective Studies; D013557:Switzerland; D014508:Urea / Q000097:blood
chemical_list: D002860:Chromium Radioisotopes; D014508:Urea; D004492:Edetic Acid; D003404:Creatinine