title: Preparation of type-specific anti-M streptococcal sera by ummunization with acid-hydrolyzed cells.
abstract: The present study describes a method which simplifies the preparation of type-specific anti-M streptococcal sera. The procedure is based on vaccination with acid-hydrolyzed cells. The method makes possible the preparation of antisera from M strains which are problematic by conventional vaccination and is very useful for preparing all anti-M sera. The antisera obtained by the above method are devoid or almost devoid of cross-reactive antibodies.
mesh_terms: D000907:Antibodies, Bacterial; D000918:Antibody Specificity; D003429:Cross Reactions; D007106:Immune Sera; D005779:Immunodiffusion; D007158:Immunologic Techniques; D013291:Streptococcus / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial; D007106:Immune Sera