Mechanism of hycanthone mutagenesis: the induction of temperature-sensitive mutations in Drosophila melanogaster.
A total of 358 sex-linked recessive lethals induced by hycanthone methane sulphonate (HMS) were checked for temperature sensitivity, along with 239 EMS-induced lethals as a positive control. Only about 1-2% of the HMS-induced lethals were temperature-sensitive, in contrast to about 7-8% for EMS-induced lethals. This can be reasonably explained by assuming that in Drosophila, HMS mainly acts by inducing frame-shift mutations or deletions.
D000818:Animals; D004331:Drosophila melanogaster / Q000187:drug effects / Q000502:physiology; D005804:Genes, Lethal; D006826:Hycanthone / Q000494:pharmacology*; D009154:Mutation / Q000187:drug effects*; D013696:Temperature; D013892:Thioxanthenes / Q000494:pharmacology*
D013892:Thioxanthenes; D006826:Hycanthone