Peritoneal anaphylaxis in the rat after sensitization with mouse antiserum.
Passive peritoneal anaphylaxis in rats, sensitized with mouse antiserum, had characteristics of an IgE-mediated reaction, in that the serum was heat-labile and pretreatment of the rats with disodium cromoglycate (DSCG), or sodium nivimedone, inhibited the release of both histamine and slow-reacting substance of anaphylaxis (SRS-A). Sodium nivimedone was more potent than DSCG as an inhibitor of histamine release. Peak concentrations of histamine and SRS-A in the peritoneal fluids of the rats, were reached within 2 min of antigen challenge and fell to control levels after 20-30 min.
D000707:Anaphylaxis; D000818:Animals; D001202:Ascitic Fluid / Q000276:immunology*; D004396:Coloring Agents; D004205:Cromolyn Sodium / Q000494:pharmacology; D006632:Histamine; D007106:Immune Sera / Q000494:pharmacology; D008297:Male; D051379:Mice; D009504:Neutrophils / Q000276:immunology; D051381:Rats; D013189:SRS-A; D013997:Time Factors
D004396:Coloring Agents; D007106:Immune Sera; D013189:SRS-A; D006632:Histamine; D004205:Cromolyn Sodium