title: Benign sickle cell anemia in Israeli-Arabs with high red cell 2,3 diphosphoglycerate.
abstract: Arabs living near the Sea of Galilee were found to be homozygous for hemoglobin S. Studies of solubility, mechanical precipitability, electrophoretic mobility on starch-gel and citrate agar media, minimum gelling concentration, and peptide mapping of the hemoglobin beta-chain confirmed complete identity of the hemoglobin with that found in Afro-American hemoglobin S homozygotes. A comparison of Arab Hb S homozygotes with Afro-American Hb S patients showed no significant differences in hemoglobin levels, red cell indices or morphology. Hb F averaged 4.4% in Arab patients. The 2,3 diphosphoglycerate levels were increased approximately twofold in Arabs, whereas in Afro-Americans, it was increased by only 7% in females and 20% in males.
mesh_terms: D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000097:blood / Q000453:epidemiology*; D044383:Black People; D004163:Diphosphoglyceric Acids / Q000097:blood*; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006451:Hemoglobin, Sickle / Q000032:analysis; D006801:Humans; D007557:Israel; D008297:Male; D012529:Saudi Arabia / Q000208:ethnology; D012737:Sex Factors
chemical_list: D004163:Diphosphoglyceric Acids; D006451:Hemoglobin, Sickle