[Aggravation of experimental dysentery in mice and acceleration of the process of multiplication of pathogenic and conditionally pathogenic bacteria under the effect of yeast RNA].
Simultaneous infection of mice with Sh. flexneri subtype 2a, culture, with various doses of RNA sodium salt (NaRNA) or administration of the preparation 3 hours prior to or 6, 12, and 18 hours after the infection was accompanied by aggravation of the experimental infection in mice. This was expressed in a greater number of animals which contracted the disease and died, and in increased blood and peritoneal exudate microbiol density. The same processes were noted in mice infected with equal doses of shigella cultures passaged four times through broth with NaRNA, in comparison with the animals infected with shigellae passaged through broth alone. Incubation of a number of pathogenic and conditionally pathogenic microbes in broth with NaRNA was accompanied by a significant increase in the bacterial biomass volume; at the same time other conditionally patoogenic microbes or even different strains of the same type of the microbes reacted to NaRNA but weakly. A possibility of realization of all of these processes in vivo and their influence on the origination of bacterial complications and development of the infection is supposed.
D000818:Animals; D003470:Culture Media; D004405:Dysentery, Bacillary / Q000150:complications / Q000382:microbiology*; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development / Q000472:pathogenicity; D066298:In Vitro Techniques; D051379:Mice; D011514:Proteus vulgaris / Q000187:drug effects / Q000254:growth & development / Q000472:pathogenicity; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000254:growth & development / Q000472:pathogenicity; D012313:RNA / Q000494:pharmacology*; D012477:Salmonella enteritidis / Q000187:drug effects / Q000254:growth & development / Q000472:pathogenicity; D012763:Shigella flexneri / Q000472:pathogenicity*; D012965:Sodium Chloride / Q000494:pharmacology*; D013210:Staphylococcus / Q000187:drug effects / Q000254:growth & development / Q000472:pathogenicity
D003470:Culture Media; D012965:Sodium Chloride; D012313:RNA
Utiazhenie eksperimental'noĭ dizenteriĭnoĭ infektsii u mysheĭ i uskorenie razmnozheniia patogennykh i uslovno-patogennykh bakteriĭ pod vliianien drozhzhevoĭ RNK.