The effect of duodenal acidification on gastric circulation and function in the dog.
The effect of acidification of duodenal contents on splanchnic bloodflow and gastric circulation was investigated in anaesthetized dogs by measuring electromagnetically portal venous and left gastric artery bloodflow and gastric mucosa bloodflow with pertechnetate clearance. Duodenal acidification increased portal venous bloodflow and reduced mesenteric inflow resistance. At the same time bloodflow in the gastric artery and (not significantly) in the mucosa were reduced in consequence of increased inflow resistances.
D000818:Animals; D004285:Dogs; D004386:Duodenum; D005753:Gastric Mucosa / Q000098:blood supply; D006851:Hydrochloric Acid / Q000494:pharmacology*; D007419:Intestinal Secretions; D008642:Mesenteric Veins / Q000187:drug effects; D011168:Portal System / Q000187:drug effects; D012039:Regional Blood Flow / Q000187:drug effects*; D013153:Splanchnic Nerves / Q000502:physiology; D013270:Stomach / Q000098:blood supply*
D006851:Hydrochloric Acid