Nifurtimox-induced alterations in the cell-mediated immune response to PPD tin guinea-pigs.
Positive skin reactions to PPD in guinea-pigs immunized with Freund's complete adjuvant (FCA) were reversed after treatment with 10 mg/kg/day nifurtimox for 12 days. The in vitro migration of peripheral blood leucocytes from FCA-immunized guinea-pigs was inhibited with PPD, but it returned to normal values after nifurtimox treatment. Furthermore, the cell-free supernatant from PPD-stimulated lymphocytes from FCA-immunized nifurtimox-treated guinea-pigs did not inhibit the migration of normal cells. Thus the administration of nifurtimox impaired the specific cell-mediated immune response to PPD both in vivo and in vitro.
D000818:Animals; D002464:Cell Migration Inhibition; D014355:Chagas Disease / Q000188:drug therapy; D005620:Freund's Adjuvant / Q000008:administration & dosage; D006168:Guinea Pigs; D007111:Immunity, Cellular / Q000187:drug effects*; D007962:Leukocytes / Q000276:immunology; D009547:Nifurtimox / Q000494:pharmacology*; D009581:Nitrofurans / Q000494:pharmacology*; D012882:Skin Tests; D013601:T-Lymphocytes / Q000187:drug effects; D014373:Tuberculin
D009581:Nitrofurans; D014373:Tuberculin; D005620:Freund's Adjuvant; D009547:Nifurtimox