6-substituted 1-methylquinolinium-2-dithioacetic acid zwitterions: antileukemia activity.
Condensation of the anhydro bases derived from 6-substituted 1-methylquinaldinium iodides with carbon disulfide provided the 2-dithioacetic acid zwitterions. Since 1.6-dimethylquinolinium-2-dithioacetic acid zwitterion previously showed appreciable activity against P-388 lymphocytic leukemia in mice, a series of analogs with other 6-substituents was synthesized to assess the importance of substitution in this position. Both electron-donating and electron-attracting 6-substituents gave compounds with antileukemia activity. The 6-unsubstituted analog had only marginal activity.
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D007942:Leukemia, Experimental / Q000188:drug therapy; D008722:Methods; D051379:Mice; D011806:Quinolinium Compounds / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D011806:Quinolinium Compounds