[Immune hemolytic anemia and thrombocytopenia after peroral therapy with a penicillin derivative (phenoxymethylpenicillin)].
A previously apparently healthy male patient developed Coombs-positive haemolytic anaemia and thrombocytopenia during phenoxymethylpenicilline intake. A drug dependent IgG red cell antibody was demonstrated in patient's serum. In vitro tests with patient's serum suggested formation of complexes involving penicilline which by complement mediated mechanisms were able to agglutinate red cells in saline medium. Platelet agglutinins were demonstrated in patient's serum but their drug dependence has not been fully elucidated. The mechanism of drug mediated autoantibody synthesis might have been involved in the pathogenesis of thrombocytopenia.
D000328:Adult; D000744:Anemia, Hemolytic, Autoimmune / Q000139:chemically induced* / Q000276:immunology; D003165:Complement System Proteins / Q000032:analysis; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D009304:Nasopharyngitis / Q000188:drug therapy; D010404:Penicillin V / Q000009:adverse effects* / Q000627:therapeutic use; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000276:immunology
D007074:Immunoglobulin G; D003165:Complement System Proteins; D010404:Penicillin V
Imuna hemoliticka anemija i trombocitopenija u toku lecenja penicilinskim derivatom za peroralnu upotrebu (fenoksimetilpenicilin).