Lactic acidosis complicating diabetic ketosis in a patient with hyperthyroidism.
The present report describes a patient with insulin-dependent diabetes who developed simultaneously lactic acidosis and ketoacidosis following insulin deprivation. Administration of insulin at low doses rapidly corrected both ketosis and lactic acidosis. There had been neither circulatory collapse, nor phenformin intake, and hepatic function was normal. The development of lactic acidosis in this case was possibly precipitated by hyperthyroidism. A review of the literature indicates that lactic acidosis is a very rare complication of diabetic ketosis per se.
D000138:Acidosis / Q000209:etiology; D000368:Aged; D001639:Bicarbonates / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000188:drug therapy; D016883:Diabetic Ketoacidosis / Q000150:complications* / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005990:Glycerol / Q000097:blood; D006801:Humans; D006885:Hydroxybutyrates / Q000097:blood; D006980:Hyperthyroidism / Q000150:complications*; D007328:Insulin / Q000627:therapeutic use; D007773:Lactates / Q000378:metabolism; D011188:Potassium / Q000097:blood
D001639:Bicarbonates; D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D006885:Hydroxybutyrates; D007328:Insulin; D007773:Lactates; D005990:Glycerol; D011188:Potassium