Mode of action of the 2-nitroimidazole derivative benznidazole.
Using cultures of Trypanosoma cruzi cells in a liquid medium, the mode of action of the 2-nitroimidazole derivative benznidazole was examined. Benznidazole inhibits protein synthesis and RNA synthesis in T. cruzy. The DNA synthesis is only slightly decreased and no effect on the aerobic respiration of T. cruzi was observed.
D000818:Animals; D014355:Chagas Disease / Q000188:drug therapy; D055598:Chemical Phenomena; D002621:Chemistry; D004247:DNA / Q000096:biosynthesis; D051379:Mice; D009593:Nitroimidazoles / Q000494:pharmacology* / Q000627:therapeutic use; D010101:Oxygen Consumption; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis; D014349:Trypanosoma cruzi / Q000187:drug effects* / Q000378:metabolism
D009593:Nitroimidazoles; D012313:RNA; D004247:DNA