[Effect of physical overloads on the state of the cardiomyocytes in experimental autoimmune cardiomyopathy].
Morphology and energetic processes in the myocardium of rats suffering from autoimmune cardiomyopathy, and their changes under the influence of physical load were studied. Chronic cardiac insufficiency in autoimmune cardiomyopathy is explained by a decreased level of adenosin triphosphate (ATP) and creatinphosphate (CP), death of some cardiomyocytes, atrophy of contractile myofilaments in the working cells and disorders at the level of micro circulation bed. Physical load resulted in the appearance of ultrastructural signs of acute cardiac insufficiency without significant changes in the initial low content of ATP and CP, but with a high total creatinphosphokinase activity. Such a reaction of cardiomyocytes of the heart to physical load in autoimmune cardiomyopathy is due to the disorders in the process of energy transportation at the level of mitochondrial crystae.
D000818:Animals; D001327:Autoimmune Diseases / Q000378:metabolism / Q000473:pathology*; D009202:Cardiomyopathies / Q000378:metabolism / Q000473:pathology*; D007114:Immunization; D008854:Microscopy, Electron; D008931:Mitochondria, Muscle / Q000648:ultrastructure; D009206:Myocardium / Q000378:metabolism / Q000648:ultrastructure*; D005082:Physical Exertion; D051381:Rats; D013550:Swimming; D013997:Time Factors
Vliianie fizicheskikh peregruzok na sostoianie kardiomiotsitov pri éksperimental'noĭ autoimmunnoĭ kardioiopatii.