Distribution of 14C-formaldehyde after pulpotomy with formocresol.
Pulpotomies were performed on rhesus monkeys with use of formocresol to determine if there was uptake of 14C-formaldehyde into the systemic circulation after formocresol pulpotomies. Five-minute exposure of pulpal tissue to the 14C-formocresol resulted in the systemic absorption of approximately 1% of the dose. Two hours of exposure of pulp tissue to the 14C-formocresol did not increase the systemic absorption. Multiple sequential pulpotomies resulted in proportionately higher systemic absorption of 14C-formaldehyde. Application of 131I to pulpotomy sites indicated that formocresol compromises the microcirculation of the dental pulp. Autoradiography disclosed extensive concentrations of 14C-formaldehyde in the pulp, dentin, periodontal ligament, and bone.
D000042:Absorption; D000818:Animals; D001345:Autoradiography; D002250:Carbon Radioisotopes / Q000378:metabolism; D005260:Female; D005557:Formaldehyde / Q000097:blood / Q000378:metabolism* / Q000652:urine; D005566:Formocresols / Q000378:metabolism / Q000627:therapeutic use*; D000882:Haplorhini; D007457:Iodine Radioisotopes / Q000097:blood / Q000378:metabolism; D008253:Macaca mulatta; D008297:Male; D011672:Pulpotomy; D013997:Time Factors
D002250:Carbon Radioisotopes; D005566:Formocresols; D007457:Iodine Radioisotopes; D005557:Formaldehyde