title: PRL-8-53: enhanced learning and subsequent retention in humans as a result of low oral doses of new psychotropic agent.
abstract: The effect of 3-(2-benzylmethylaminoethyl) benzoic acid methyl ester hydrochloride (PRL-8-53) on learning and on retention of verbal information in human subjects was investigated. Using the serial anticipation method under double-blind conditions it was found that PRL-8-53 causes slight improvement of acquisition. Retinetion of verbal information was found improved to a statistically significant degree (most P values better than 0.01, some better than 0.001). No significant changes were found for either visual reaction time or motor control after drug when compared with placebo values.
mesh_terms: D001565:Benzoates / Q000009:adverse effects / Q000494:pharmacology*; D005021:Ethylamines / Q000009:adverse effects / Q000494:pharmacology; D006801:Humans; D007858:Learning; D008568:Memory / Q000187:drug effects*; D009048:Motor Skills / Q000187:drug effects; D011619:Psychotropic Drugs / Q000009:adverse effects / Q000494:pharmacology*; D011930:Reaction Time / Q000187:drug effects; D012153:Retention, Psychology / Q000187:drug effects*; D013268:Stimulation, Chemical; D013997:Time Factors
chemical_list: D001565:Benzoates; D005021:Ethylamines; D011619:Psychotropic Drugs; C006732:PRL-8-53