Histaminase release from human eosinophils.
Phagocytosis of opsonized zymosan by human eosinophils results in a dose-dependent noncytotoxic release of histaminase as well as arylsulfatase and beta-glucuronidase. The calcium ionophore A23187 also stimulates release of eosinophil histaminase at concentrations of ionophore which barely release arylsulfatase and beta-glucuronidase. Zymosan-induced histaminase release from eosinophils but not from neutrophils was abolished or markedly reduced in the presence of cytochalasin B, suggesting a difference in the mechanisms of histaminase release from the two granulocyte cell types.
D006631:Amine Oxidase (Copper-Containing) / Q000378:metabolism*; D001192:Arylsulfatases / Q000378:metabolism; D000001:Calcimycin / Q000494:pharmacology; D003571:Cytochalasin B / Q000494:pharmacology; D004804:Eosinophils / Q000378:metabolism*; D005966:Glucuronidase / Q000378:metabolism; D006801:Humans; D009895:Opsonin Proteins; D015054:Zymosan / Q000494:pharmacology
D009895:Opsonin Proteins; D000001:Calcimycin; D003571:Cytochalasin B; D015054:Zymosan; D006631:Amine Oxidase (Copper-Containing); D001192:Arylsulfatases; D005966:Glucuronidase