[Behavior modifications induced by unilateral administration of picrotoxin into rat substantia nigra].
Intranigral injection of picrotoxin in Rats induced contralateral rotation and stereotyped behaviour. These responses were significantly altered following neuroleptic treatment (haloperiod, pimozide) or ipsilateral striatal electrolytic destruction. The present results provide behavioural evidence for gamma-aminobutyric acid-mediated inhibition of the dopaminergic nigrostriatal pathway.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D006220:Haloperidol / Q000494:pharmacology; D006801:Humans; D008297:Male; D010852:Picrotoxin / Q000008:administration & dosage* / Q000494:pharmacology; D010868:Pimozide / Q000494:pharmacology; D051381:Rats; D012399:Rotation; D013239:Stereotyped Behavior / Q000187:drug effects; D013378:Substantia Nigra / Q000187:drug effects / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D006220:Haloperidol; D010852:Picrotoxin; D010868:Pimozide; D005680:gamma-Aminobutyric Acid
Modifications de comportement provoquées par administration unilatérale de picrotoxine dans la substance noire du rat.