Environmental hydrocarbons produce degeneration in cat hypothalamus and optic tract.
2,5-Hexanedione, the principal neurotoxic metabolite of the industrial solvents n-hexane and methyl n-butyl ketone causes axonal degeneration in the mammillary body and visual nuclei of cats. Prolonged, low-level exposure to hydrocarbons in the environment may cause premature deterioration in areas of the human brain vital for perception and behavior.
D000818:Animals; D001369:Axons / Q000473:pathology; D002415:Cats; D004785:Environmental Pollutants / Q000633:toxicity*; D005829:Geniculate Bodies / Q000187:drug effects; D006588:Hexanones / Q000633:toxicity*; D007659:Ketones / Q000633:toxicity*; D008326:Mammillary Bodies / Q000187:drug effects* / Q000473:pathology; D009410:Nerve Degeneration / Q000187:drug effects*; D013477:Superior Colliculi / Q000473:pathology; D014795:Visual Pathways / Q000187:drug effects* / Q000473:pathology
D004785:Environmental Pollutants; D006588:Hexanones; D007659:Ketones