Partial inhibition of postreplication repair and enhanced frequency of chemical transformation in rat cells infected with leukemia virus.
Postreplication repair of DNA and chemical transformation with the carcinogen 4-nitroquinoline-1-oxide were studied in rat cell lines either uninfected or infected with Rauscher leukemia virus. The results indicate that equivalent amounts of carcinogen are bound to the DNA initially and removed during excision repair. However, the lines differ in that the infected line alone exhibits both sensitivity to nitroquinoline-oxide-induced transformation and a partial inhibition of the postreplication repair process after notroquinoline oxide or UV treatment.
D015112:4-Nitroquinoline-1-oxide / Q000378:metabolism / Q000494:pharmacology / Q000528:radiation effects; D000818:Animals; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D004247:DNA / Q000096:biosynthesis / Q000378:metabolism / Q000528:radiation effects; D004260:DNA Repair / Q000187:drug effects / Q000528:radiation effects; D004305:Dose-Response Relationship, Drug; D008970:Molecular Weight; D009600:Nitroquinolines / Q000494:pharmacology; D011925:Rauscher Virus; D014412:Tumor Virus Infections / Q000378:metabolism*
D009600:Nitroquinolines; D015112:4-Nitroquinoline-1-oxide; D004247:DNA