title: Endocarditis related to transvenous pacemakers. Syndromes and surgical implications.
abstract: Two cases of microbial endocarditis related to transvenous pacemakers illustrate syndromes whose pathogenesis we consider to be distinctive. Acute Pseudomonas aeruginosa endocarditis related to a pacemaker developed in a 75-year-old man, an event which to our knowledge has not been previously described. There was no evidence of generator site infection, and the sequence of events indicated metastatic implantation of bacteria on traumatized endothelium. A 76-year-old women with a 3 year history of local generator site infection and recurrent fever was found to have extensive vegatative Staphylococcus epidermidis endocarditis at cardiotomy. The sequence of events indicated gradual spread of infection locally, related to the contaminated foreign body. Awareness of these separate pathogenetic mechanisms should facilitate recognition and appropriate management. Removal of the entire pacing system and prolonged antibiotic therapy were considered to be essential to cure of infection in both instances.
mesh_terms: D000368:Aged; D002228:Carbenicillin / Q000627:therapeutic use; D002506:Cephalexin / Q000627:therapeutic use; D002512:Cephalothin / Q000627:therapeutic use; D004697:Endocarditis, Bacterial / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D010138:Pacemaker, Artificial / Q000009:adverse effects*; D011552:Pseudomonas Infections / Q000188:drug therapy / Q000209:etiology*; D011550:Pseudomonas aeruginosa; D018805:Sepsis / Q000209:etiology; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000209:etiology*; D014031:Tobramycin / Q000627:therapeutic use
chemical_list: D002228:Carbenicillin; D002506:Cephalexin; D002512:Cephalothin; D014031:Tobramycin