In vitro anti-mycobacterial activity of some new amino-glycoside antibiotics.
Four new aminoglycoside antibiotics, namely gentamycin, amikacin, tobramycin and sisiomycin were tested against several pathogenic strains of so-called 'typical' and 'atypical' mycobacteria. Only amikacin exhibited considerable in vitro anti-mycobacterial activity against Mycobacterium tuberculosis and not against other mycobacterial pathogens. None of the other three antibiotics exhibited activity against any of the mycobacteria at low concentrations.
D000583:Amikacin / Q000494:pharmacology*; D005839:Gentamicins / Q000494:pharmacology; D007612:Kanamycin / Q000031:analogs & derivatives*; D009161:Mycobacterium / Q000187:drug effects*; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D009170:Nontuberculous Mycobacteria / Q000187:drug effects; D012853:Sisomicin / Q000494:pharmacology; D014031:Tobramycin / Q000494:pharmacology
D005839:Gentamicins; D007612:Kanamycin; D000583:Amikacin; D014031:Tobramycin; D012853:Sisomicin