Transient monoclonal immunoglobulin G with anti-dextran activity.
A patient with regional enteritis had received iron dextran for treatment of iron deficiency. Subsequently he developed a large (3.1 g/100 ml) IgG-K serum spike which had precipitin activity against dextran sulfate but not a variety of other antigens. There has been no evidence of multiple myeloma and the spike gradually disappeared spontaneously over the course of 2 years. We speculate that the monoclonal protein may have developed as a response to the iron dextran injections under the immunologic stress of a chronic inflammatory disease.
D000328:Adult; D003424:Crohn Disease / Q000276:immunology*; D006801:Humans; D006942:Hypergammaglobulinemia / Q000139:chemically induced*; D007074:Immunoglobulin G; D007505:Iron-Dextran Complex / Q000276:immunology*; D008297:Male
D007074:Immunoglobulin G; D007505:Iron-Dextran Complex