[Quantitative analysis of conditional-optimal doses of succilep and trimetin in the treatment of children and adolescents with minor forms of epilepsy].
On the basis of a study of 156 patients the authors with the aid of a computer convened a dispersion analysis of interaction found in the process of treatment by conditional optimal doses of trimetin and succilep with 23 clinical parameters of the disease. It was established that on a statistically significant level the largest dose of trimetin (per 1 kg of body weight) was required in the treatment of myoclonic forms of seizures, with duration less that one year, pathological changes in the craniogram, signs of hypertension and the absence of prenatal noxious factors and pathology in the neurological state. The interaction of optimal doses of succilep with the cliniel characteristics is less expressed than for Trimetin and on a significant level is detected only for two of them: a larger dosage in longer duration of the disease and in the existence of prenatal noxious factors in the past history. It was established that with years the used amount of trimetin adn saccilep (per 1 kg of body weight) declines, while the therapeutical effectiveness does not drop.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004832:Epilepsy, Absence / Q000188:drug therapy*; D006801:Humans; D013388:Succinimides / Q000008:administration & dosage* / Q000627:therapeutic use; D014293:Trimethadione / Q000008:administration & dosage
D013388:Succinimides; D014293:Trimethadione
Kolichestvennyĭ analiz uslovno-optimal'nykh doz suksilepa i trimetina pri lechenii malykh form épilepsii u deteĭ i podrostkov.