Histopathogenesis of skin and subcutaneous injury induced by adriamycin.
Extravasation of Adriamycin from an intravenous needle or catheter can produce a progressive skin necrosis and deep painful ulceration. The pathological changes which result in this ulceration were studied in a rabbit model. The earliest changes include vascular obliteration and necrobiosis of collagen. At no point were inflammatory cells found to play a primary role.
D000818:Animals; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects*; D007271:Injections, Intradermal; D008297:Male; D011817:Rabbits; D012867:Skin / Q000473:pathology*; D012883:Skin Ulcer / Q000139:chemically induced / Q000473:pathology; D014456:Ulcer / Q000139:chemically induced* / Q000473:pathology
D004317:Doxorubicin