Collagen-induced arthritis in rats. Comparison of vitreous and cartilage-derived collagens.
An oil emulsion of purified type II collagen from bovine articular cartilage when injected intradermally into rats induced an inflammatory polyarthritis in 4 of 12 animals. When similarly injected, collagen purified from bonve vitreous induced arthritis in 6 of 12 animals. Studies of humoral and cell-mediated immunity to both collagen preparations demonstrated complete cross-reactivity. It is concluded that vitreous collagen shares the arthritogenic property of cartilage-derived type II collagen and that collagen from the two sources is indistinguishable in arthritogenic and immunologic properties.
D000818:Animals; D000917:Antibody Formation; D001168:Arthritis; D001169:Arthritis, Experimental; D002358:Cartilage, Articular / Q000276:immunology*; D002417:Cattle; D003094:Collagen / Q000008:administration & dosage / Q000276:immunology* / Q000302:isolation & purification; D005260:Female; D006385:Hemagglutination Inhibition Tests; D006386:Hemagglutination Tests; D007114:Immunization; D007271:Injections, Intradermal; D008213:Lymphocyte Activation / Q000187:drug effects; D008722:Methods; D051381:Rats; D014822:Vitreous Body / Q000276:immunology*
D003094:Collagen