Antiviral and interferon-inducing properties of 1,5-diamino anthraquinones.
A series of anthraquinones with amino substituents at the 1,5 positions were found to induce interferon in mice. A prototype compound, 1,5-bis[(3-morpholinopropyl)amino]-anthraquinone (Ia), was an effective antiviral agent when administered either orally or parenterally. Peak interferon titers were found 12 to 24 h after drug treatment. The minimum oral dose of Ia required to induce serum interferon or to protect mice against a lethal virus infection was 62 mg/kg. Mice tolerated an oral dose of at least 30 times this minimum effective dose. A single dose of Ia given up to 6 days prior to infection had significant protective activity. Biological properties of Ia were compared with those of three other 1,5-diamino anthraquinones, which also induced interferon and demonstrated antiviral activity in mice. The most active compound was 1,5-bis[[2-(diethylamino)ethyl]amino]-anthraquinone (Ib), which protected mice against virus infection at a dose as low as 8 mg/kg (less than 1/60 its maximum tolerated dose). Mice developed hyporeactivity to interferon induction if the same inducer was injected daily, although by alternating between different inducers the loss of interferon responsiveness could be avoided.
D000818:Animals; D000880:Anthraquinones / Q000494:pharmacology*; D000998:Antiviral Agents; D004305:Dose-Response Relationship, Drug; D006736:Horses; D006801:Humans; D007369:Interferon Inducers; D007372:Interferons / Q000097:blood; D051379:Mice
D000880:Anthraquinones; D000998:Antiviral Agents; D007369:Interferon Inducers; D007372:Interferons