Chimpanzee livers after infection with human hepatitis viruses A and B: Ultrastructural studies.
Electron microscopical studies were carried out on coded liver biopsy specimens from chimpanzees inoculated with human hepatitis A or B virus. Hepatitis B was recognized by the presence of hepatitis B core particles in hepatocellular nuclei. Hepatitis A was characterized by unidentified large, dense, and more irregular heterochromatin-like particles in hepatocellular nuclei coincidental with peak aminotransferase activities. As type A hepatitis illness became manifest in the chimpanzees, mitochondrial cristae were curled and attenuated, and clusters of endoplasmic reticulum were tightly packed. In contrast, the livers in viral hepatitis B showed mainly hypertrophy of tubular smooth endoplasmic reticulum. This suggested different pathogenetic mechanisms in A and B chimpanzee viral hepatitis.
D000818:Animals; D002467:Cell Nucleus / Q000648:ultrastructure; D002986:Clinical Trials as Topic; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D000882:Haplorhini; D006506:Hepatitis A / Q000473:pathology*; D006509:Hepatitis B / Q000473:pathology*; D006512:Hepatitis B Core Antigens / Q000648:ultrastructure; D008099:Liver / Q000648:ultrastructure*; D008247:Lysosomes / Q000648:ultrastructure; D008930:Mitochondria, Liver / Q000648:ultrastructure; D002679:Pan troglodytes
D006512:Hepatitis B Core Antigens