Blood group D antigen content of nucleated red cell precursors.
The D antigen content of nucleated red cell precursors in human bone marrow was estimated using autoradiography and 125I-anti-D. D antigen first appeared in the pronormoblast, and the quantity of antigen progressively increased during red cell maturation. Maximal anti-D binding occurred on mature red blood cells. Pronormoblasts, basophilic normoblasts, polychromatophilic normoblasts, and orthochromatic normoblasts, respectively, had approximately 1/4, 1/2, 2/3, and 3/4 the quantity of antigen found on mature red cells. None of the other cell types were found in bone marrow labeled with anti-D.
D001345:Autoradiography; D002648:Child; D004900:Erythroblasts / Q000276:immunology*; D004910:Erythrocyte Membrane / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology*; D006801:Humans; D007945:Leukemia, Lymphoid / Q000276:immunology; D012204:Rh-Hr Blood-Group System
D012204:Rh-Hr Blood-Group System