Rubella in Jerusalem. 2. Clinical and serologic findings in children with congenital rubella.
Forty-eight children born with clinical and serologic manifestations of congenital rubella were followed for a three-year period. Expanded rubella syndrome, multiple anomalies and single defects were found, mostly in the child's first year of life. Some new organic problems were found at a later age in children who had initially been healthy but who had been followed up because of their high antibody levels to rubella. Of the 48 children, 15 (31%) were born to mothers who had had clinically and serologically diagnosed rubella during pregnancy. In 33 children (69%) the mother had had asymptomatic rubella. These findings emphasize the need to identify and immunize seronegative women before pregnancy.
D000015:Abnormalities, Multiple / Q000209:etiology; D000328:Adult; D000914:Antibodies, Viral / Q000302:isolation & purification; D000013:Congenital Abnormalities / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007557:Israel; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000635:transmission; D012409:Rubella / Q000150:complications / Q000151:congenital* / Q000453:epidemiology / Q000635:transmission; D012412:Rubella virus / Q000276:immunology; D014504:Urban Health
D000914:Antibodies, Viral