title: Determinant of efficiency of a monomeric enzyme: acceleration by site-specific molecules for trypsin.
abstract: The interaction of a specific ligand at substrate binding site was shown to be responsible for the catalytic efficiency of trypsin. The reasoning of 'induced fit' theory was refined by kinetic analysis of characteristic properties of 'inverse' substrates.
mesh_terms: D001550:Benzamidines / Q000494:pharmacology; D001665:Binding Sites; D002384:Catalysis; D004789:Enzyme Activation / Q000187:drug effects; D007700:Kinetics; D008024:Ligands; D011487:Protein Conformation; D013329:Structure-Activity Relationship; D014357:Trypsin / Q000378:metabolism*
chemical_list: D001550:Benzamidines; D008024:Ligands; D014357:Trypsin