Effects of suloctidil on lipid metabolism in experimental animals.
A novel potent vasoactive agent, 1-(4-isopropyl-thiophenyl)-2-n-octylaminopropanol (suloctidil, Sulocton), lowers excess of plasma cholesterol and tends to normalize the plasma hyperbetalipoproteinemia of Rhesus monkeys fed a high-cholesterol, high-fat diet. The drug shows an inhibitory effect on the cholesterol biosynthesis in rat liver homogenates.
D000818:Animals; D002784:Cholesterol / Q000096:biosynthesis / Q000097:blood; D005227:Fatty Acids / Q000097:blood; D000882:Haplorhini; D066298:In Vitro Techniques; D050356:Lipid Metabolism; D008074:Lipoproteins / Q000097:blood; D008099:Liver / Q000378:metabolism; D008253:Macaca mulatta; D008297:Male; D010743:Phospholipids / Q000097:blood; D011412:Propanolamines / Q000494:pharmacology*; D051381:Rats
D005227:Fatty Acids; D008074:Lipoproteins; D010743:Phospholipids; D011412:Propanolamines; D002784:Cholesterol