Hv(1), a variable-region genetic marker of human immunoglobulin heavy chains.
A new antigenic determinant was discovered with a hemagglutination-inhibition assay system. Designated Hv(1), it is located in the variable region of human immunoglobulin heavy chains of the G, M, and A classes. Pedigree and population analyses suggest that it has an autosomal dominant mode of inheritance. This represents the first description of an allotypic determinant in the variable region of human immunoglobulins.
D001666:Binding Sites, Antibody; D005796:Genes; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000235:genetics; D007141:Immunoglobulin Fc Fragments / Q000235:genetics; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D007135:Immunoglobulin Variable Region; D010375:Pedigree
D007140:Immunoglobulin Fab Fragments; D007141:Immunoglobulin Fc Fragments; D007143:Immunoglobulin Heavy Chains; D007135:Immunoglobulin Variable Region