Inhibition of iron uptake and deoxyribonucleic acid synthesis by Desferal in a mutant strain of Bacillus subtilis.
In the Bacillus subtilis mutant 1D-4, the hydroxamate Desferal inhibited growth, iron uptake, and deoxyribonucleic acid synthesis but did not quantitatively affect synthesis of ribonucleic acid and protein.
D001412:Bacillus subtilis / Q000187:drug effects* / Q000378:metabolism; D001426:Bacterial Proteins / Q000096:biosynthesis; D001692:Biological Transport / Q000187:drug effects; D004269:DNA, Bacterial / Q000096:biosynthesis*; D006877:Hydroxamic Acids / Q000494:pharmacology*; D007501:Iron / Q000378:metabolism*; D012329:RNA, Bacterial / Q000096:biosynthesis
D001426:Bacterial Proteins; D004269:DNA, Bacterial; D006877:Hydroxamic Acids; D012329:RNA, Bacterial; D007501:Iron