title: Oxytocic activity of two dihydrogenated ergot peptide alkaloids on the rabbit uterus in situ.
abstract: The effect of two recently synthetized dihydrogenated ergot peptide alkaloids has been investigated on the rabbit uterus in situ. The method is described in detail. 6-Nor-6-isopropyl-9,10-dihydro-2'beta-methyl-5'alpha-benzyl-ergopeptine (DZ 26-474) and 6-nor-6-idopropyl-9,10-dihydro2'8-methyl-5'alpha-isopropyl-ergopeptine (28-377) possess 33% and 59%, respectively, of the oxytocic activity of methylergometrine (Methergine). The uterotonic effect of DZ 26-474 and 28-377 can be completely abolished by pretreatment with alpha-adrenoceptor blocking drugs, indicating involvement of alpha-adrenoceptors. Results obtained are discussed in relation to the concept that dihydrogenated ergot peptide alkaloids usually inhibit spontaneous contractions of the uterus and contractions induced by methylergometrine.
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004877:Ergoloid Mesylates / Q000494:pharmacology*; D005260:Female; D010120:Oxytocics; D010643:Phenoxybenzamine / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D011817:Rabbits
chemical_list: D010120:Oxytocics; D010643:Phenoxybenzamine; D004877:Ergoloid Mesylates; D010646:Phentolamine