title: Drug interactions with oral sulphonylurea hypoglycaemic drugs.
abstract: The effect of the oral sulphonylurea hypoglycaemic drugs may be influenced by a large number of other drugs. Some of these combinations (e.g. phenylbutazone, sulphaphenazole) may result in cases of severe hypoglycaemic collapse. Tolbutamide and chlorpropamide should never be given to a patient without a prior careful check of which medicaments are already being given. Similarly, no drug should be given to a diabetic treated with tolbutamide and chlorpropamide without consideration of the possibility of interaction phenomena.
mesh_terms: D000493:Allopurinol / Q000494:pharmacology; D000700:Analgesics / Q000494:pharmacology; D000925:Anticoagulants / Q000494:pharmacology; D002701:Chloramphenicol / Q000494:pharmacology; D002747:Chlorpropamide / Q000494:pharmacology; D004221:Disulfiram / Q000494:pharmacology; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology; D005905:Glyburide / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D000960:Hypolipidemic Agents / Q000494:pharmacology; D007700:Kinetics; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D009675:Novobiocin / Q000494:pharmacology; D010653:Phenylbutazone / Q000494:pharmacology; D010672:Phenytoin / Q000494:pharmacology; D011339:Probenecid / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D012293:Rifampin / Q000494:pharmacology; D013449:Sulfonamides / Q000494:pharmacology; D013453:Sulfonylurea Compounds / Q000494:pharmacology*; D014044:Tolbutamide / Q000378:metabolism / Q000494:pharmacology
chemical_list: D000700:Analgesics; D000925:Anticoagulants; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D008996:Monoamine Oxidase Inhibitors; D013449:Sulfonamides; D013453:Sulfonylurea Compounds; D009675:Novobiocin; D000431:Ethanol; D010672:Phenytoin; D000493:Allopurinol; D002701:Chloramphenicol; D014044:Tolbutamide; D011433:Propranolol; D010653:Phenylbutazone; D011339:Probenecid; D005905:Glyburide; D004221:Disulfiram; D012293:Rifampin; D002747:Chlorpropamide