[Effects of Tabermanthe iboga H. Bn. alkaloids on the isolated organ responses to catecholamines and the role of calcium exchanges. Tabernanthine].
Using isolated Rat duodenum previously decalcified, the authors have investigated the effect of tabernanthine on the increase of tonus brought about by addition of calcium ions at different concentrations. The observed potentiating effect of tabernanthine towards the calcium responses may be pointed out concerning the mechanism of sensitizing effect of this alkaloid on the responses of isolated organs to catecholamines such as noradrenaline and dopamine.
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D001692:Biological Transport; D002118:Calcium / Q000378:metabolism* / Q000494:pharmacology; D004298:Dopamine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004386:Duodenum / Q000187:drug effects / Q000378:metabolism*; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology*; D010946:Plants, Medicinal; D051381:Rats
D000470:Alkaloids; D002118:Calcium; D004298:Dopamine; D009638:Norepinephrine
Effets des alcaloïdes du Tabernanthe Iboga H. Bn. sur les réponses des organes isolés aux catécholamines et rôle des échanges de calcium. Cas de la tabernanthine.