title: Pre-estrogen breast irradiation for patients with carcinoma of the prostate: a critical review.
abstract: We studied 38 patients with prostatic cancer who received breast irradiation before oral estrogen administration. Our data are combined with those from other institutions to determine the effectiveness of pre-estrogen breast irradiation in minimizing gynecomastia and/or pain. Based on our review the incidence of estrogen-induced breast changes is 70%. Irradiation given before estrogen administration can prevent or minimize these changes in 89.3% of the treated patients. Histologic changes of gynecomastia are reviewed and recommendations for optimum radiation therapy technique are included.
mesh_terms: D001940:Breast / Q000528:radiation effects*; D004054:Diethylstilbestrol / Q000009:adverse effects* / Q000627:therapeutic use; D005069:Evaluation Studies as Topic; D006177:Gynecomastia / Q000139:chemically induced* / Q000517:prevention & control; D006801:Humans; D008297:Male; D010146:Pain; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D011829:Radiation Dosage; D013997:Time Factors
chemical_list: D004054:Diethylstilbestrol