title: Glycinothricin, a new streptothricin-class antibiotic from Streptomyces griseus.
abstract: Glycinothricin is a streptothricin-class antibiotic obtained for the first time from the culture broth of a strain of Streptomyces griseus. Glycinothricin, the deformimino derivative of antibiotic LL-AB664, gives N-methylstreptolidine, N-methyl-D-glucosamine and glycine on acid hydrolysis. In comparison with LL-AB664, glycinothricin is less active against gram-positive and gram-negative bacteria and less toxic to mice.
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification*; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D005285:Fermentation; D006868:Hydrolysis; D007928:Lethal Dose 50; D051379:Mice; D013305:Streptomyces griseus / Q000145:classification / Q000378:metabolism*; D013309:Streptothricins / Q000096:biosynthesis / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D013309:Streptothricins