title: In vitro effects of melanocytolytic agents and other compounds upon dominant human melanoma tyrosinase activity.
abstract: The activity of dominant human melanoma tyrosinase isozyme was greatly decreased by certain reducing agents. The number and geometry of phenolic groups as well as free--SH group appear important for enzymic inhibition.
mesh_terms: D004156:Catechol Oxidase / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D007527:Isoenzymes / Q000378:metabolism; D008545:Melanoma / Q000201:enzymology*; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D010636:Phenols / Q000494:pharmacology; D013438:Sulfhydryl Compounds / Q000494:pharmacology
chemical_list: D007527:Isoenzymes; D010636:Phenols; D013438:Sulfhydryl Compounds; D004156:Catechol Oxidase; D014442:Monophenol Monooxygenase