Regulation of the expression of autoimmunity in NZB x NZW F1 mice by sex hormones.
This study examines the role of sex hormones in modulating the expression of autoimmunity in NZB x NZW F1 mice. Male sex hormones were found to retard disease. Differences were noted between prepubertally and postpubertally altered males and females. The presence of male sex hormones prepubertally was associated with marked retardation of the development of antibodies to DNA. Prepubertal but not postpubertal castration of males led to significant acceleration in anti-DNA production. Nevertheless, administration of male sex hormones to females retarded the development of fatal glomerulonephritis, even when given postpubertally. These results suggest that manipulation of sex hormones may be used to modify the expression of autoimmunity.
D000818:Animals; D001327:Autoimmune Diseases / Q000235:genetics*; D005260:Female; D005786:Gene Expression Regulation; D012739:Gonadal Steroid Hormones / Q000502:physiology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains
D012739:Gonadal Steroid Hormones