[Preferential differentiation of hematopoietic stem cells transferred to mice previously infected by BCG].
Following injection of bone marrow cells in lethally irradiated mice, previously infected with BCG regenerating hemopoietic cell populations differentiate along the leucocyte pathway to the detriment of erythroid lineage. Such a phenomenon persisting even if anemia of infected mice is increased by bleeding just before irradiation and reconstitution supports the hypothesis of preferential differentiation of stem cells.
D000818:Animals; D001500:BCG Vaccine; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D002417:Cattle; D004920:Erythropoiesis / Q000528:radiation effects; D005260:Female; D006410:Hematopoiesis; D007962:Leukocytes / Q000166:cytology*; D008297:Male; D051379:Mice; D009163:Mycobacterium bovis; D013154:Spleen / Q000166:cytology; D014184:Transplantation, Homologous; D014380:Tuberculosis, Bovine / Q000097:blood / Q000503:physiopathology*
D001500:BCG Vaccine
Différenciation préférentielle des cellules souches hématopoïétiques transférées chez des souris irradiées préalablement infectées par du BCG.