Effect of toloxatone on behaviour of primates.
1. The effects of (3-methyl)-3-phenyl-5-hydroxy-methyl-2-oxazolidinone (toloxatone) were studied on the behaviour of three species of primates: baboon, rhesus monkeys and chimpanzee. 2. The activity against reserpine-induced depression is observed in baboon as in rodents. 2. The administration of toloxatone induces three effects which probably have the same origin: suppression of feeding inhibition of the subordinate baboon, improvement of escape reaction in the conditioned chimpanzee, increase in general activity and the active component of social behaviour in grouped rhesus monkeys. These three effects can be interpreted as resulting from the stimulating effect of toloxatone, or more precisely from a disinhibiting effect. 4. Contrary to amphetamine, toloxatone does not induce, even at high or repeated doses, behavioural disturbances.
D000284:Administration, Oral; D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001066:Appetite / Q000187:drug effects; D001067:Appetite Depressants; D001522:Behavior, Animal / Q000187:drug effects*; D004924:Escape Reaction / Q000187:drug effects; D005247:Feeding Behavior; D000882:Haplorhini; D007273:Injections, Intramuscular; D008253:Macaca mulatta; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D010080:Oxazoles / Q000008:administration & dosage / Q000494:pharmacology*; D002679:Pan troglodytes; D010215:Papio; D012890:Sleep / Q000187:drug effects
D001067:Appetite Depressants; D010080:Oxazoles; D000661:Amphetamine