Rapid increase of fibrinolytic activity in pig and rat after exclusion of the liver from the circulation and its control by various organs.
Liver-bypass in the pig and the rat instantly results in a marked increase of fibrinolytic activity. Within 1--2 hours this increase is followed in rats by a normalization. A new increase can be obtained by intravenous Carbachol injection. Removal of organs results to various degrees -- most pronounced after bilateral nephrectomy -- in reduction of control value of fibrinolytic activity before liver-bypass. In rats with adrenalectomy plus splenectomy there is no normalization of liver-bypass-induced increased fibrinolytic activity.
D000315:Adrenalectomy; D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D005112:Extracorporeal Circulation; D005342:Fibrinolysis / Q000187:drug effects; D005343:Fibrinolytic Agents / Q000097:blood*; D008099:Liver / Q000601:surgery; D008102:Liver Circulation; D009392:Nephrectomy; D051381:Rats; D013156:Splenectomy; D013552:Swine
D005343:Fibrinolytic Agents; D002217:Carbachol