Microbial formation of 4-thiouracil.
A soil organism identified as Streptomyces libani var. soldani was found to produce 4-thiouracil. The product was isolated in a yield of 150 mug/ml of filtered beer and characterized by C-13 magnetic resonance and high-resolution mass spectroscopy. The product has a broad antibacterial spectrum but low specific activity.
D001412:Bacillus subtilis / Q000187:drug effects; D005285:Fermentation; D008826:Microbial Sensitivity Tests; D013302:Streptomyces / Q000378:metabolism*; D013889:Thiouracil / Q000096:biosynthesis* / Q000494:pharmacology
D013889:Thiouracil