title: [Meconium aspiration syndrome with severe hypoxemia. Treatment with a pulmonary vasodilator (tolarzoline) (author's transl)].
abstract: Three patients with Meconium Aspiration Syndrome (S.A.M.) and severe hypoxemia are reported. From the first hours of life they needed mechanical ventilation, showing no improvement in PaO2 in spite of usual respiratory support measures. In one case, pulmonary hypertension and ductal right to left shunt through ductus arteriosus and foramen ovale was objetivated by cardiac catheterization. Following intravenous prefusion of a pulmonary vasodilator (Tolazoline) patients showed a clinical amelioration and a definite increase in PaO2. Results and evolution with the use of this drug are commented.
mesh_terms: D004374:Ductus Arteriosus, Patent / Q000150:complications; D005260:Female; D006801:Humans; D006819:Hyaline Membrane Disease / Q000150:complications / Q000188:drug therapy*; D006976:Hypertension, Pulmonary / Q000188:drug therapy* / Q000209:etiology; D000860:Hypoxia / Q000188:drug therapy* / Q000209:etiology; D007231:Infant, Newborn; D007275:Injections, Intravenous; D008297:Male; D008470:Meconium / Q000187:drug effects; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D014043:Tolazoline / Q000008:administration & dosage*
chemical_list: D014043:Tolazoline; D010100:Oxygen
vernacular_title: Síndrome de aspiración meconial con hipoxemia grave. Tratamiento con un vasodilatador pulmonar (tolazolina).