[Investigations on the antimicrobial activity of amin-aldehydecondensates. 1. (Communication:) Symmetrically substituted animals of formaldehyde (author's transl)].
In the scope of our research about the antimicrobial activity of aldehyde-amin-condenates a number of partly new aminals was synthesized by reaction of formaldehyde with various secondary amines. Structures and physically constants are shown in the tables 1 and 2. The antimicrobial activity is demonstrated by the results of the disk-test (table 3), of the minimal inhibition concentration (MIC, talbe 4) and the suspension and area disinfecting test following the method of the DGHM (tables 5 and 6). Standardized formulations were developed to eliminate the different solubility effects of the various aminals. These formulations do not influence the test results. It may be shown, that aminals have both germistatic activity mainly versus Staphylococcus aureus, Bacillus subtilis, Aspergillus niger and Penicillium glaucum and germicidal activity especially versus Pseudomonas aeruginosa, Trichophyton mentagrophytes and Microsporium gypseum.
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D001234:Aspergillus niger / Q000187:drug effects; D001412:Bacillus subtilis / Q000187:drug effects; D001419:Bacteria / Q000187:drug effects*; D002176:Candida albicans / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D003959:Diamines / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D005658:Fungi / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D010407:Penicillium / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D003959:Diamines
Untersuchungen zur antimikrobiellen Wirksamkeit von Amin-Aldehydkondensaten 1. Mitteilung: Symmetrisch substituierte Formaldehydaminale.