The effect of alpha adrenergic blockade on spinal cord autoregulation in the monkey.
Spinal cord blood flow (SCBF) was measured over a wide range of artificially varied mean systemic arterial blood pressures (MAP) in a group of monkeys with alpha adrenergic receptors blocked by the intravenous administration of phenoxybenzamine (Dibenzyline). The SCBF was found to vary linearly with changes in MAP. Autoregulation appeared to have been abolished. These data are cited as evidence for a dominant role of the sympathetic nervous system in control of the spinal circulation.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002200:Capillary Resistance / Q000187:drug effects; D005260:Female; D000882:Haplorhini; D006706:Homeostasis; D008252:Macaca fascicularis; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D010643:Phenoxybenzamine / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000187:drug effects; D013116:Spinal Cord / Q000098:blood supply*
D010643:Phenoxybenzamine; D009638:Norepinephrine