Induced helical conformation of ionic polypeptides by phospholipids solubilized in a nonionic surfactant solution.
Phosphatidylcholine that has been solubilized in hexadecylpoly (oxyethylene) ether can induce a coil-to-helix transformation for poly (L-glutamic acid) in neutral solution. Similarly, solubilized phosphatidylserine promotes a helical conformation of poly (L-lysine) at neutral pH through complex formation. The mixed micelles of a phospholipid and a nonionic surfactant are thermodynamically stable and do not separate on standing. The nonionic surfactant here has no effect on the conformation of the two polypeptides.
D000596:Amino Acids / Q000032:analysis; D055598:Chemical Phenomena; D002621:Chemistry; D008968:Molecular Conformation; D010455:Peptides / Q000032:analysis*; D010713:Phosphatidylcholines; D010718:Phosphatidylserines; D010743:Phospholipids / Q000032:analysis*
D000596:Amino Acids; D010455:Peptides; D010713:Phosphatidylcholines; D010718:Phosphatidylserines; D010743:Phospholipids