Incorporation of H3-leucine in the mouse kidney in thrombocytopenia. Attempt to demonstrate thrombopoietin production.
Light and dark field autoradiography of semithin sections prepared 6 h after a treatment with APS showed that the incorporation of H3-leucine into the cells of the convoluted tubules of the kidney was increased in mice. There was no difference in the H3-leucine incorporation in the liver, either in thrombocytopenic or in untreated animals. The increased incorporation of leucine in the kidney in APS-induced thrombocytopenia showed coincidence with increased thrombopoietin production.
D000818:Animals; D001792:Blood Platelets / Q000276:immunology; D006023:Glycoproteins / Q000096:biosynthesis*; D007668:Kidney / Q000378:metabolism*; D007930:Leucine / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D013921:Thrombocytopenia / Q000209:etiology / Q000378:metabolism*; D013926:Thrombopoietin / Q000096:biosynthesis*
D006023:Glycoproteins; D013926:Thrombopoietin; D007930:Leucine