[Reduction of efferent renal nerve activity by propranolol in rabbits].
During intravenous infusion of propranolol (0.3--0.8 mg/kg) in the Rabbit, systolic arterial pressure is decreased (-6.5 +/- 4.2 mmHg) and electrical activity recorded from central end of the renal nerve is reduced significantly (-8.7 +/- 14.-%) with regard to the activity obtained, at the same pressure levels, by hemorrhage (+7.9 +/- 6.4%; p less than 0.25) or by intravenous infusion of the peripheral vasodilator sodium nitroprusside (+14.1 +/- 9.9%; p less than 0.01).
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001815:Bloodletting / Q000009:adverse effects; D007022:Hypotension / Q000139:chemically induced / Q000209:etiology / Q000503:physiopathology; D007668:Kidney / Q000294:innervation*; D008564:Membrane Potentials / Q000187:drug effects; D009476:Neurons, Efferent / Q000187:drug effects / Q000502:physiology; D009599:Nitroprusside; D011433:Propranolol / Q000494:pharmacology*; D011817:Rabbits; D013153:Splanchnic Nerves / Q000187:drug effects* / Q000502:physiology
D009599:Nitroprusside; D011433:Propranolol
Réduction de l'activité efférente du nerf rénal sous l'action du propranolol chez le Lapin.