title: Mitosis of type B alveolar cells in the early hyperplastic response to Freund's adjuvant.
abstract: Numerous areas of granulomatous inflammation develop in the lungs of rabbits following the intravenous injection of Freund's complete adjuvant (FCA). Within a few days after FCA injection, hyperplasia of type B (type I) alveolar cells is present on the surface of the septa in which an inflammatory reaction is developing. Mitosis of type B cells is detected 12 h after FCA injection and is common over the next 120 h. In addition, there are morphologic changes that are consistent with migration of these cells. The type B cells in mitosis extend across alveolar septa as well as along the alveolar surface. The extension of type B cells through alveolar septa is not limited to cells in mitosis, but is also observed in non-mitotic type B cells. Stimulation of mitosis and hyperplasia of type B cells is discussed in relation to the focal tissue injury and inflammatory response.
mesh_terms: D000818:Animals; D002465:Cell Movement; D004847:Epithelial Cells; D005620:Freund's Adjuvant; D006965:Hyperplasia; D008854:Microscopy, Electron; D008938:Mitosis; D011650:Pulmonary Alveoli / Q000473:pathology*; D011817:Rabbits
chemical_list: D005620:Freund's Adjuvant