Comparative study of chromogenesis and endotoxin production from pathogenic Pseudomonas aeruginosa strains, isolated from neoplastic processes.
Several differences in relation to the chromogenesis and the production of endotoxins were found in Ps. aeruginosa strains, isolated from tumors. The strains isolated from neoplastic processes showed a higher amount of chromogenic fractions as compared with the control strains. Phenazinic compounds presented the main differences. Using two common methods of isolation and purification of Gram-negative endotoxin, we found a higher yield of these molecules in the case of tumor-isolated strains.
D000818:Animals; D004731:Endotoxins / Q000096:biosynthesis* / Q000633:toxicity; D006801:Humans; D007928:Lethal Dose 50; D008070:Lipopolysaccharides / Q000096:biosynthesis / Q000633:toxicity; D051379:Mice; D009369:Neoplasms / Q000382:microbiology* / Q000532:radiotherapy; D010619:Phenazines / Q000378:metabolism; D010860:Pigments, Biological / Q000096:biosynthesis*; D011135:Polysaccharides, Bacterial / Q000096:biosynthesis / Q000633:toxicity; D011550:Pseudomonas aeruginosa / Q000378:metabolism*; D011817:Rabbits; D013045:Species Specificity
D004731:Endotoxins; D008070:Lipopolysaccharides; D010619:Phenazines; D010860:Pigments, Biological; D011135:Polysaccharides, Bacterial