title: Disseminated intravascular coagulation: a review of its pathogenesis, manifestations and treatment.
abstract: Disseminated intravascular coagulation is a clinicopathologic process of man and animals which occurs secondary to many diseases. The process may manifest in a variety of clinical syndromes including medical shock, haemorrhage, haemolysis and organ failure. A diagnosis can be confirmed by detecting a deficiency of several haemostatic components and the presence of raised levels of circulating fibrinogen (fibrin) degradation products. Therapy of the disorder includes the removal of the initiating factors which have provoked the clotting process together with the use of anticoagulants. The disease processes in which disseminated intravascular coagulation is implicated in the dog are enumerated.
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000627:therapeutic use; D001777:Blood Coagulation; D001808:Blood Vessels / Q000502:physiology; D004211:Disseminated Intravascular Coagulation / Q000175:diagnosis / Q000209:etiology / Q000628:therapy / Q000662:veterinary*; D004283:Dog Diseases / Q000175:diagnosis*; D004285:Dogs; D004727:Endothelium / Q000502:physiology; D005343:Fibrinolytic Agents / Q000378:metabolism; D010973:Platelet Adhesiveness
chemical_list: D000925:Anticoagulants; D005343:Fibrinolytic Agents