[Endotoxin recognition with myelopoiesis of monocytes and macrophages].
Cells from the monocyte-macrophage pathway release colony-stimulating factors. The release of colony-stimulating activity is increased upon endotoxin activation in the presence of fresh serum. Heat-inactivation of serum (56 degrees C, 30 minutes) abolishes the endotoxin-mediated activation of macrophages. Decomplementation with zymosan, iodipamide and the use of commercially serum deficient in C3 provide indirect evidence for a complement dependence of the endotoxin-macrophage interaction, which leads to release of colony-stimulating activity.
D003114:Colony-Forming Units Assay; D003115:Colony-Stimulating Factors / Q000276:immunology*; D004731:Endotoxins / Q000276:immunology*; D006098:Granulocytes / Q000276:immunology; D006801:Humans; D008214:Lymphocytes / Q000276:immunology; D008264:Macrophages / Q000276:immunology*; D009000:Monocytes / Q000276:immunology*; D012486:Salmonella typhimurium
D003115:Colony-Stimulating Factors; D004731:Endotoxins
Untersuchungen über die Erkennung von Endotoxin mit nachfolgender Umwandlung in einen myelopoetischen Stimulus durch Monozyten und Makrophagen.