title: [11-azasteroids. V. Hormonal properties of 11-azaestranes].
abstract: Experiments were conducted on sexually-immature female rats, ovariectomized mice and castrated male rats. Hormonal properties of some 11-azaestran were studied. As shown, introduction of azafunction into the position of the 11 molecule of the steroid sharply reduced the hormonal activity, irrespective of other functions in the molecule determining the reference of the steroid to the estron, estradiol, or 19-nortestosterone series.
mesh_terms: D045930:Anabolic Agents; D000818:Animals; D001378:Azasteroids / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000494:pharmacology; D004962:Estranes / Q000494:pharmacology*; D004965:Estrogen Antagonists; D004970:Estrone / Q000494:pharmacology; D005260:Female; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D013260:Steroids, Heterocyclic / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D045165:Testosterone Congeners; D014599:Uterus / Q000187:drug effects*; D014621:Vagina / Q000187:drug effects*
chemical_list: D045930:Anabolic Agents; D001378:Azasteroids; D004962:Estranes; D004965:Estrogen Antagonists; D013260:Steroids, Heterocyclic; D045165:Testosterone Congeners; D004970:Estrone; D004958:Estradiol
vernacular_title: 11-azasteroids. V. Hormonal properties of 11-azaéstranes.