Effect of aspirin and vitamins C and E on synovial rheumatoid arthritic and other cells.
Normal and rheumatoid arthritic human synovial cells, normal rat muscle and bone cells, were cultured with combinations of aspirin (acetylsalicytic acid), vitamins C and E. Aspirin reduced percent growth of all cells by about 1/5 relative to controls. High vitamin C eradicated arthritic cells. In combinations, vitamin C was most important in eradicating arthritic cells. A low-vitamin C combination was most effective in reducing arthritic cell populations, while having little effect on normal cells. Vitamin E retarded but did not prevent the action of vitamin C.
D001172:Arthritis, Rheumatoid / Q000473:pathology*; D001205:Ascorbic Acid / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology*; D001842:Bone and Bones / Q000166:cytology; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006801:Humans; D009132:Muscles / Q000166:cytology; D013582:Synovial Fluid / Q000166:cytology*; D014810:Vitamin E / Q000494:pharmacology*
D014810:Vitamin E; D001205:Ascorbic Acid; D001241:Aspirin