Mutagenic evaluation of clonazepam using in vitro and in vivo bacterial tests.
The mutagenicity of an anti-epileptic drug, clonazepam, and its metabolites was studied by three repair (rec, pol and uvr) assays and reversion (Ames') tests. No detectable induction of mutation could be found in any tests by them per se or via metabolism in rat and mouse.
D000818:Animals; D001412:Bacillus subtilis / Q000187:drug effects / Q000235:genetics; D001570:Benzodiazepinones / Q000494:pharmacology*; D002998:Clonazepam / Q000494:pharmacology*; D004260:DNA Repair / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics; D008297:Male; D051379:Mice; D009153:Mutagens / Q000494:pharmacology*; D009154:Mutation; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics
D001570:Benzodiazepinones; D009153:Mutagens; D002998:Clonazepam