1,25-Dihydroxyvitamin D3 increases the activity of the intestinal phosphatidylcholine deacylation-reacylation cycle.
The activity of the intestinal phosphatidylcholine deacylation-reacylation cycle has been found to be stimulated by 1,25-dihydroxy-vitamin D3. The stimulation of this cycle thus provides a possible mechanism for the reported retailoring of the fatty acid composition of phosphatidylcholine in intestinal cell membranes by 1,25-dihydroxy-vitamin D3 and its analogue, 1alpha-hydroxyvitamin D3.
D000214:Acyl Coenzyme A / Q000378:metabolism; D000215:Acylation; D000818:Animals; D004100:Dihydroxycholecalciferols / Q000494:pharmacology*; D004386:Duodenum / Q000187:drug effects / Q000378:metabolism*; D006887:Hydroxycholecalciferols / Q000494:pharmacology*; D008297:Male; D008871:Microvilli / Q000187:drug effects / Q000378:metabolism; D010713:Phosphatidylcholines / Q000378:metabolism*; D051381:Rats
D000214:Acyl Coenzyme A; D004100:Dihydroxycholecalciferols; D006887:Hydroxycholecalciferols; D010713:Phosphatidylcholines