title: Biologic assessment of copper-containing amalgams.
abstract: In order to reduce creep and avoid marginal fractures in amalgam restorations, new alloys containing higher proportions of copper have been introduced. Fillings of these materials were placed in cavities prepared in the deciduous teeth of monkeys or placed in polyethylene tubes and implanted subcutaneously in rats. Conventional silver/tin alloys and zinc oxide eugenol cement were used as reference materials. Despite limitations due to the varying depths of cavities and the small number of animals involved it was concluded that the high copper alloys caused more severe pulp damage than the other materials studied. In the implantation studies many of the high copper specimens were exfoliated before the end of the experimental period. It is concluded that in deep cavities these materials require the use of a non-toxic base or lining material although as they are commonly used in young children's teeth the placement of linings and the isolation of the cavity pose problems.
mesh_terms: D000818:Animals; D003300:Copper / Q000494:pharmacology*; D003723:Dental Amalgam / Q000494:pharmacology*; D003782:Dental Pulp / Q000187:drug effects*; D003804:Dentin / Q000187:drug effects; D000882:Haplorhini; D011671:Pulpitis; D012834:Silver / Q000494:pharmacology*; D014001:Tin / Q000494:pharmacology*; D014094:Tooth, Deciduous / Q000187:drug effects
chemical_list: D012834:Silver; D014001:Tin; D003300:Copper; D003723:Dental Amalgam