Inhibition of 3H-thymidine incorporation into the DNA of developing rat brain by amphetamine treatment.
1. The incorporation of labelled thymidine into the brain of 10 day-old rats, used as the index of mitotic activity, was decreased two hours after administration of 20-40 mg/kg doses of amphetamine phosphate. 2. The entry of precursor from the blood to the brain tissue was not disturbed. 3. The observed elevation of plasma corticosterone levels did not appear to mediate the effect. 4. Changes in the normal balance of tissue norepinephrine and dopamine levels are considered as possible inhibitory factors in glial cell proliferation.
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D004247:DNA / Q000378:metabolism*; D003864:Depression, Chemical; D005260:Female; D008297:Male; D051381:Rats; D013936:Thymidine / Q000378:metabolism*
D004247:DNA; D000661:Amphetamine; D013936:Thymidine