title: Chromosomal damage by alcohol in vitro and in vivo.
abstract: Alcohol has no damaging effects on human chromosomes in vitro. The chromosomes of alcoholics, however, show a significant elevation of aberrations. Alcohol inhibits cellular and cell free RNA synthesis. One possible reason for the mutagenic activity of alcohol in vivo may be an inhibition of cellular repair.
mesh_terms: D000328:Adult; D000375:Aging; D000434:Alcoholic Beverages; D000437:Alcoholism / Q000235:genetics; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D012321:DNA-Directed RNA Polymerases / Q000037:antagonists & inhibitors; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D011502:Protein-Energy Malnutrition / Q000235:genetics; D012737:Sex Factors
chemical_list: D000431:Ethanol; D012321:DNA-Directed RNA Polymerases