title: [4-Thiouridine and photoprotection in Escherichia coli K 12].
abstract: A high level of protection is observed in the Escherichia coli K 12 strain AB 1157 rec A 1 nuv+ whose transfer RNA contains 4-thiouridine. In contrast, the photoprotection level is low and observed at higher doses in a strain which differs from the former by a single mutation, nuv-, (lack of 4-thiouridine). This nucleoside is therefore an important chromophore leading to photoprotection. This conclusion is corroborated by the similarity of the action spectra for 8-13 link formation in tRNA and for photoprotection.
mesh_terms: D002470:Cell Survival / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D004926:Escherichia coli / Q000187:drug effects / Q000528:radiation effects*; D009154:Mutation; D012343:RNA, Transfer / Q000378:metabolism; D013891:Thiouridine / Q000378:metabolism / Q000494:pharmacology*; D014466:Ultraviolet Rays
chemical_list: D013891:Thiouridine; D012343:RNA, Transfer
vernacular_title: 4-Thiouridine et photoprotection dans Escherichia coli K 12.