[Increase in the non-specific resistance to infection in mice after oral administration of 2 synthetic glycopeptides with adjuvant activity].
Two synthetic glycopeptides (MurNAc-L-Ala-D-isoGln and MurNAc-L-Ala-D-Glu), having adjuvant activity, were shown to enhance non-specific resistance to infection against K. pneumoniae. These compounds were active by various routes including oral administration and even if administered after the challenge. Two steroisomers lacking adjuvant activity did not protect the infected Mice.
D000276:Adjuvants, Immunologic; D000284:Administration, Oral; D000818:Animals; D006020:Glycopeptides / Q000008:administration & dosage / Q000627:therapeutic use*; D007710:Klebsiella Infections / Q000517:prevention & control*; D007711:Klebsiella pneumoniae; D051379:Mice; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000276:Adjuvants, Immunologic; D006020:Glycopeptides
Augmentation de la résistance non spécifique à l'infection de la souris après administration orale de deux glycopeptides synthétiques doués d'activité adjuvante