[Contribution to the study of ontogeny of the cells synthetizing IgE class immunoglobulins (author's transl)].
It is known that a treatment, initiated with birth, of repeated injections of anti-mu heavy chain sera leads in mice to considerable decrease of the serum level of the various classes of immunoglobulins : IgM, IgA, IgG1, IgG2. A similar treatment led to similar results in rats but, in addition, made it clear that the IgE serum level was also decreased by the treatment. Moreover, a series of injections of an anti-rat IgD serum also produced a significative decrease of the IgE serum level. The results suggest that the precursor cells of the IgE plasma cells are bearing molecules of IgM and IgD classes on their membrane.
D000818:Animals; D007111:Immunity, Cellular; D007070:Immunoglobulin A; D007072:Immunoglobulin D; D007073:Immunoglobulin E / Q000096:biosynthesis*; D007143:Immunoglobulin Heavy Chains; D007075:Immunoglobulin M; D051379:Mice; D011817:Rabbits; D051381:Rats
D007070:Immunoglobulin A; D007072:Immunoglobulin D; D007143:Immunoglobulin Heavy Chains; D007075:Immunoglobulin M; D007073:Immunoglobulin E
Contribution à l'étude de l'ontogenèse des cellules synthétisant les immunoglobulines de classe IgE.