title: Determination of glomerular function in advanced renal failure.
abstract: In 15 children with advanced chronic renal failure, glomerular filtration rate was determined by different methods. Inulin clearance correlated well with the mean of creatinine and urea clearance, and also with 51-chromium edetic acid (EDTA) clearance measured over 24 hours. The absolute values of creatinine clearance and of 51Cr-EDTA clearance measured up to 8 hours were higher than inulin clearance. In advanced renal failure both the 51Cr-EDTA clearance measured over 24 hours, and the mean of creatinine and urea clearance, provide acceptable estimates of true glomerular filtration rate.
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000652:urine; D004492:Edetic Acid / Q000378:metabolism; D005919:Glomerular Filtration Rate; D006801:Humans; D007444:Inulin / Q000652:urine; D007676:Kidney Failure, Chronic / Q000503:physiopathology*; D008722:Methods; D014508:Urea / Q000652:urine
chemical_list: D014508:Urea; D007444:Inulin; D004492:Edetic Acid; D003404:Creatinine