[The evidence capacity of the lymphocyte-transformation-test and the quantitative immunoglobulin-determination in sarcoidosis (author's transl)].
In 50 patients suffering from a cytologically or histologically confirmed sarcoidosis the unspecific transformation rate by PHA in the lymphocyte-transformation-test (LTT) and the immunoglobulins IgA, IgG, IgM and IgD have been determined by the help of a simple radial immunodiffusion. The evaluation of the LTT took place morphologically. 600 cells were counted each set-up (3 different smears each PHA-set-up). For the purpose of a better morphological presentation of lymphoblasts in the LTT a smear of alkalineous hydrolysis was fixed and followed by a colouring according to PAPPENHEIM. There was a decreased PHA-transformation-rate in sarcoidosis as a symptom for a partial defect within the cellular immune area. The levels of immunoglobulins showed no deviations as against to standard values.
D006801:Humans; D005779:Immunodiffusion; D007136:Immunoglobulins / Q000378:metabolism*; D037102:Lectins / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects*; D011239:Prednisolone / Q000494:pharmacology / Q000627:therapeutic use; D012507:Sarcoidosis / Q000188:drug therapy / Q000276:immunology*
D007136:Immunoglobulins; D037102:Lectins; D011239:Prednisolone
Aussagefähigkeit des Lymphozytentransformationstestes und der quantitativen Immunglobulinbestimmung bei Sarkoidose.