title: [Role of cellular organelles in the reproduction of the influenza virus].
abstract: Virus-cell interaction may result in changes of both cell population and the original properties of the persisting virus. The elucidation of infectious RNA localization is of undoubtful interest in the light of the investigation of the mechanism of chronic influenza infection. The studies were aimed at comparing chronic and acute infections on the model of influenza virus. Particularly important were the studies on comparative distribution of the virus infectious activity among cell organoids. The investigation of virus accumulation in subcellular fractions in chronic infection revealed infectivity in the lysosomal fraction. This fact led to an important hypothesis on possible lysosomal virus carrier state. It has also been shown that activation and redistribution of the acid phosphatase activity occurs in virus infection of cells. The activity of the enzyme in cell juice was absent in the chronic and present in the acute infection.
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D002478:Cells, Cultured; D002642:Chick Embryo; D004789:Enzyme Activation; D006387:Hemagglutination, Viral; D006801:Humans; D009980:Influenza A virus / Q000472:pathogenicity / Q000502:physiology*; D008247:Lysosomes / Q000382:microbiology; D009439:Neuraminidase / Q000378:metabolism; D009940:Organoids / Q000382:microbiology*; D014779:Virus Replication
chemical_list: D000135:Acid Phosphatase; D009439:Neuraminidase
vernacular_title: O roli kletochnykh organell v reproduktsii virusa grippa.