title: Effects of Cannabis sativa on ultrastructure of the synapse in monkey brain.
abstract: Electron microscopic study of brain tissues of monkeys chronically exposed to psychoactive Cannabis showed widening of the synaptic cleft, electron opaque material in the cleft and in pre- and postsynaptic regions, and some "clumping" of synaptic vesicles. In contrast, tissues of control monkeys showed no ultrastructural changes.
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000648:ultrastructure; D013759:Dronabinol / Q000008:administration & dosage / Q000633:toxicity*; D000882:Haplorhini; D007275:Injections, Intravenous; D008854:Microscopy, Electron; D013569:Synapses / Q000187:drug effects* / Q000648:ultrastructure
chemical_list: D013759:Dronabinol