6-Hydroxydopamine inhibits some effects of mescaline centrally administered to rabbits.
The narcotic antagonist naloxone does not antagonize antinociception elicited in the rabbit by 100 microgram/kg of mescaline centrally administered, whereas pretreatment with 6-hydroxydopamine (6-OHDA) inhibits this mescaline effect. Stereotyped behavior of rabbits following central mescaline administration is also prevented by 6-hda pretreatment. Since 6-OHDA in known to produce a degeneration of catecholamine containing nerve terminals, a crucial role of catecholamines is suggested in the complex of effects seen in the rabbit after central administration of the hallucinogen.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D006892:Hydroxydopamines / Q000008:administration & dosage / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D008635:Mescaline / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D009270:Naloxone / Q000008:administration & dosage / Q000494:pharmacology; D011817:Rabbits
D006892:Hydroxydopamines; D009270:Naloxone; D008635:Mescaline