Control of elevated pulmonary vascular resistance in neonatal swine with prostacyclin (PGI2).
Three groups of neonatal piglets were anesthetised and base-line hemodynamic measurements were made. The piglets were then subjected to hypoxia and hypercapnea to raise pulmonary vascular resistance (PVR) and further hemodynamic measurements were made over a period of at least 100 minutes. During the last 80 minutes of this period the control group received an infusion of 0.05M Tris buffer [the vehicle for prostacyclin (PGI2)], the second group received an infusion of 0.5 microgram/kg/min PGI2, and the third group received an infusion of 1.0 microgram/kg/min PGI2.
D000818:Animals; D000831:Animals, Newborn; D011464:Epoprostenol / Q000494:pharmacology*; D006935:Hypercapnia / Q000503:physiopathology; D000860:Hypoxia / Q000503:physiopathology; D011453:Prostaglandins / Q000494:pharmacology*; D011465:Prostaglandins, Synthetic / Q000494:pharmacology; D011652:Pulmonary Circulation / Q000187:drug effects*; D013552:Swine; D014655:Vascular Resistance / Q000187:drug effects*; D014664:Vasodilation / Q000187:drug effects
D011453:Prostaglandins; D011465:Prostaglandins, Synthetic; D011464:Epoprostenol