[Mode of action at the cellular level of new thiopyrimidines with antimitotic properties].
New thiopyrimidine derivatives have been synthesized. Among them, several inhibit the multiplication of Chick embryo cells cultivated in vitro: they provoke strong nucleolar alterations, prevent the cells from entering into mitosis and can give rise to cell polyploidisation as to DNA.
D000818:Animals; D002466:Cell Nucleolus / Q000187:drug effects; D002478:Cells, Cultured; D002642:Chick Embryo; D004247:DNA / Q000378:metabolism; D008938:Mitosis / Q000187:drug effects*; D011123:Polyploidy; D011506:Proteins / Q000378:metabolism; D011725:Pyridines / Q000494:pharmacology*; D011743:Pyrimidines / Q000494:pharmacology; D012313:RNA / Q000378:metabolism; D013329:Structure-Activity Relationship
D011506:Proteins; D011725:Pyridines; D011743:Pyrimidines; D012313:RNA; D004247:DNA
Mode d'action au niveau cellulaire de nouvelles substances pyrimidiques soufrées à propriétés antimitotiques9h