Heterologous growth of human ovarian cancer. A new in vivo testing system.
Successful heterotransplantation of ovarian cancer in the mouse mutant, nude is described, with serial transmission, in one case to date. Light and electron microscopic examination of this tumour, a poorly differentiated adenocarcinoma, has not revealed any alteration in its morphology after six passages. Tumour-bearing mice have been treated with ThioTEPA or 5-Fluoro-Uracil, in an attempt to see if they show a similar effect to that seen in the patient. ThioTEPA resulted in a marked regression, whilst there was no effect from 5-Fluoro-Uracil, on tumour growth--confirming the ThioTEPA effect seen in the patient.
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000648:ultrastructure; D000818:Animals; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007273:Injections, Intramuscular; D007274:Injections, Intraperitoneal; D051379:Mice; D008819:Mice, Nude; D008854:Microscopy, Electron; D008875:Middle Aged; D009368:Neoplasm Transplantation; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000648:ultrastructure; D013852:Thiotepa / Q000008:administration & dosage / Q000627:therapeutic use*; D014183:Transplantation, Heterologous
D013852:Thiotepa; D005472:Fluorouracil