Evaluation of antigen-induced buffy coat leucocyte aggregation as a simple test of allergic reactivity.
The phenomenon of antigen-induced aggregation of human buffy coat leucocytes correlates well with skin testing using purified protein derivative of tuberculin as the antigen and in this system appears to be a simple, sensitive test of cell-mediated immunity. The same phenomenon may, however, be used as an indicator of humoral immunity. In addition antigen-induced buffy coat leucocyte aggregation is suppressed by serum from patients with Hodgkin's disease and sarcoidosis. The possible uses and also the limitations of this test are discussed.
D000818:Animals; D000917:Antibody Formation; D002449:Cell Aggregation; D005069:Evaluation Studies as Topic; D006433:Hemocyanins; D006689:Hodgkin Disease / Q000276:immunology; D007111:Immunity, Cellular; D007158:Immunologic Techniques; D007962:Leukocytes / Q000276:immunology*; D012204:Rh-Hr Blood-Group System; D014374:Tuberculin Test
D012204:Rh-Hr Blood-Group System; D006433:Hemocyanins