An immunoglobulin heavy chain variable region (VH) marker associated with cross-reactive idiotypes in man.
The VH specificities of two rabbit antisera raised against the H chains of two human IgM cold agglutinins were studied with the aid of proteins on which the VH sequence data are available. They were found to recognize a new VH antigen (VHMar), which may represent a subgroup of VHI. This antigen is found on anti-Ii antibodies which have cross-reactive idiotypes. It is moderately well-expressed in normal gamma globulin and strongly expressed on 8% of unselected myeloma and macroglobulinaemia proteins. There is evidence to suggest that a proportion of the cross-reactive idiotypes among the anti-Ii antibodies involve this VH antigen.
D000373:Agglutinins; D000595:Amino Acid Sequence; D000918:Antibody Specificity; D000941:Antigens; D001666:Binding Sites, Antibody; D003080:Cold Temperature; D003429:Cross Reactions; D006801:Humans; D007048:I Blood-Group System; D007074:Immunoglobulin G; D007143:Immunoglobulin Heavy Chains; D007135:Immunoglobulin Variable Region; D009194:Myeloma Proteins / Q000276:immunology
D000373:Agglutinins; D000941:Antigens; D007048:I Blood-Group System; D007074:Immunoglobulin G; D007143:Immunoglobulin Heavy Chains; D007135:Immunoglobulin Variable Region; D009194:Myeloma Proteins