[Experimental studies on the schistosomicidal activity of the aminobenzaldehyde derivative 80.647 (author's transl)].
In a group of aminobenzaldehyde derivatives the 2-cholor-4-(1)-piperazinobenalazine showed to be highly active in golden hamsters (Mesocricetus auratus), Mastomys natalensis and capucine monkeys (Cebus capucinus capucinus) against Schistosoma mansoni, slightly active against S. mattheei and inactive against S. haematobium and S. japonicum. The D.c.m. in mice and hamsters was 50 mg/kg body weight after a single oral dose and 20 or 50 mg/kg body weight respectively when dosed once daily on 5 consecutive days.
D000818:Animals; D001547:Benzaldehydes / Q000627:therapeutic use*; D006224:Cricetinae; D000882:Haplorhini; D006826:Hycanthone / Q000627:therapeutic use; D008647:Mesocricetus; D051379:Mice; D009560:Niridazole / Q000627:therapeutic use; D010879:Piperazines / Q000627:therapeutic use; D012547:Schistosoma / Q000187:drug effects; D012548:Schistosoma haematobium / Q000187:drug effects; D012550:Schistosoma mansoni / Q000187:drug effects; D012556:Schistosomicides
D001547:Benzaldehydes; D010879:Piperazines; D012556:Schistosomicides; D006826:Hycanthone; D009560:Niridazole
Experimentelle Untersuchungen zum schistosomiziden Wirkprofil des Aminobenzaldehydderivates 80.647