[Epithel regeneration inhibition in the treatment of Trifluorothymidin (F3TDR) (author's transl)].
After well-defined chemical and mechanical removal of the corneal epithelium from 38 rabbit eyes 19 right eyes were treated with F3TDR (Trifluorothymidine) 6 times daily, whereas the 19 left eyes were with physiologic NaCl-solution 6 times daily. The epithelial regeneration was compared with the contralateral controll-eye. No significant difference was found between both eye-series. The short-timed high dosage of F3TDR seems to have no delaying effect on epithelial regeneration.
D000818:Animals; D003315:Cornea / Q000187:drug effects*; D004848:Epithelium / Q000187:drug effects; D011817:Rabbits; D012038:Regeneration / Q000187:drug effects*; D013936:Thymidine / Q000031:analogs & derivatives*; D013997:Time Factors; D014271:Trifluridine / Q000008:administration & dosage / Q000494:pharmacology*
D014271:Trifluridine; D013936:Thymidine
Zur Frage der Epithelregenerationshemmung bei Trifluorothymidin-Behandlung (F3TDR).