Effect of chronic combined glucocorticoid and estrogen on serum androgens and androgen binding in hirsutism.
Forth-six patients with hirsutism are presented herein. Twenty-four of these patients had menstrual irregularities. Treatment with 5 mg prednisone at bedtime, and 0.625 to 1.25 mg conjugated estrogens daily except during menses resulted in a signficant decrease in serum 17 beta-ol androgens, and an even more statistically significant increase in serum androgen binding. Thus the biochemical abnormalities associated with hirsutism were improved and no apparent side effects were observed.
D000293:Adolescent; D000328:Adult; D000728:Androgens / Q000097:blood*; D013196:Dihydrotestosterone / Q000097:blood; D004359:Drug Therapy, Combination; D045166:Estradiol Congeners / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006628:Hirsutism / Q000188:drug therapy*; D006801:Humans; D011241:Prednisone / Q000494:pharmacology* / Q000627:therapeutic use; D013739:Testosterone / Q000097:blood
D000728:Androgens; D045166:Estradiol Congeners; D013196:Dihydrotestosterone; D013739:Testosterone; D011241:Prednisone