title: Propranolol effects on acute marihuana intoxication in man.
abstract: To investigate the possible interaction of a beta adrenergic blocking agent and marihuana, six healthy experienced marihuana smokers received the two drugs separately and in combination. Propranolol (120 mg per os) reduced resting HR and BP; there were no changes in performance on tasks designed to test psychomotor speed, attention, memory and learning. Marihuana (10 mg delta9-THC), administered in smoke, induced the typical subjective state ("high") with marked increases in HR, BP and conjunctival injection; it impaired performance on a learning test without significantly affecting attention. Pre-treatment with propranolol blocked effectively the cardiovascular effects of marihuana; it prevented the learning impairment and, to a lesser degree, the characteristic subjective experience.
mesh_terms: D000293:Adolescent; D000328:Adult; D001288:Attention / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D002188:Cannabis; D003228:Conjunctiva / Q000187:drug effects; D004347:Drug Interactions; D004644:Emotions / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007858:Learning / Q000187:drug effects; D008297:Male; D008568:Memory / Q000187:drug effects; D009048:Motor Skills / Q000187:drug effects; D011433:Propranolol / Q000494:pharmacology*; D013647:Task Performance and Analysis; D013997:Time Factors
chemical_list: D011433:Propranolol