Metabolism of 5-methyltetrahydrofolate by Lactobacillus casei.
The metabolism of 5-[Me-14 C]methyltetrahydrofolate in Lactobacillus casei proceeded oxidatively with incorporation of label into purine and thymidylate derivatives. No labelled methionine was formed. (l)-5-Methyltetrahydrofolate, the natural isomer, was not a substrate for the L. casei folylpoly-gamma-glutamate synthetase although the unnatural (d)-isomer was slowly metabolized to the diglutamate form.
D005971:Glutamates / Q000378:metabolism; D007780:Lacticaseibacillus casei / Q000378:metabolism*; D008715:Methionine / Q000378:metabolism; D011687:Purines / Q000378:metabolism; D011743:Pyrimidines / Q000378:metabolism; D013763:Tetrahydrofolates / Q000378:metabolism*
D005971:Glutamates; D011687:Purines; D011743:Pyrimidines; D013763:Tetrahydrofolates; D008715:Methionine