[Anti-infective activity of anti-influenza antibodies from human colostrum].
Antibodies against influenza virus of A, B serological types and PC-virus were detected in the colostrum collected after an epidemic. These antibodies belonged to the secretory IgA form. The secretory antibodies preparation made of colostrum, and its IgA fraction instilled intransally to mice and rats prevented the development of infection caused by 100--10 ID50/0.1 ml of the influenza A virus. The protective action of the antibodies of IgA class was due to its capacity to become fixed on the surface of the cells of the mucosal epithelium of the respiratory tract.
D000327:Adsorption; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis / Q000276:immunology*; D003126:Colostrum / Q000276:immunology*; D005260:Female; D006801:Humans; D007114:Immunization; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007251:Influenza, Human / Q000276:immunology*; D051379:Mice; D009975:Orthomyxoviridae / Q000276:immunology; D011247:Pregnancy; D051381:Rats
D000914:Antibodies, Viral; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M
Ob antiinfektsionnoĭ aktivnosti protivogrippoznykh antitel zhenskogo moloziva.