title: Effect of oral estramustine phosphate on pituitary, gonadal, and adrenal function in the green monkey (Cercopithecus aethiops sabaeus).
abstract: We studied the effects of estramustine phosphate on pituitary, gonadal, and adrenal function in the green monkey. A 2-week course of estramustine phosphate (75 mg per day) reversibly suppressed the luteinizing hormone and testosterone response to luteinizing hormone-releasing hormone but did not affect pituitary-adrenal function assessed by the 11-deoxycorticosterone response to metyrapone. Treatment with oral estramustine phosphate also resulted in a significant increase in corticosteroid-binding globulin but did not affect a series of liver enzymes nor hematology. The results are consistent with a pure estrogen effect produced by hydrolysis of the carbamate-ester bona at a site distant from estrogen target tissues and could explain most of the reported in vivo effects of this compound.
mesh_terms: D000284:Administration, Oral; D000311:Adrenal Glands / Q000187:drug effects*; D000818:Animals; D002522:Chlorocebus aethiops; D003900:Desoxycorticosterone / Q000097:blood; D004961:Estramustine / Q000008:administration & dosage / Q000494:pharmacology*; D007987:Gonadotropin-Releasing Hormone; D000882:Haplorhini; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008797:Metyrapone; D009588:Nitrogen Mustard Compounds / Q000494:pharmacology*; D010902:Pituitary Gland / Q000187:drug effects*; D013737:Testis / Q000187:drug effects*; D013739:Testosterone / Q000097:blood; D014156:Transcortin / Q000032:analysis
chemical_list: D009588:Nitrogen Mustard Compounds; D007987:Gonadotropin-Releasing Hormone; D004961:Estramustine; D013739:Testosterone; D003900:Desoxycorticosterone; D007986:Luteinizing Hormone; D014156:Transcortin; D008797:Metyrapone