Macroglobulinaemia in an Icelandic family.
Macroglobulinaemia in an Icelandic family is presented. A woman had Waldenström's macroglobulinaemia, and two of her brothers had monoclonal macroglobulinaemia of the benign form. One was asymptomatic, but the other had polyneuropathy and IgM deposits in peripheral nerves. A third brother of these siblings died of a lymphoreticular disease, which presented with a widespread neuropathy. A second sister had polyclonal increase in serum IgA and two other brothers of this sibship had IgM slightly elevated. A study of all descendants (45 in all and 19 spouses) revealed seven individuals with elevated IgM levels. No other immunoglobulin abnormalities were detected.
D000368:Aged; D005260:Female; D006801:Humans; D007055:Iceland; D007070:Immunoglobulin A / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D010375:Pedigree; D008258:Waldenstrom Macroglobulinemia / Q000235:genetics* / Q000276:immunology
D007070:Immunoglobulin A; D007075:Immunoglobulin M