title: Experimental pulmonary infection of mice by tracheal intubation of Pseudomonas aeruginosa: the use of antineoplastic agents to overcome natural resistance.
abstract: Tracheal intubation of viable Pseudomonas aeruginosa ATCC 19660 into the lungs of mice had no significant effect on the animals even with administration of organisms as high as 5.0 X 10(9) CFU. Animals treated with a single injection of an antineoplastic drug were, however, susceptible to bacterial challenge into the lungs. LD50 values of 4.1 X 10(7), 4.8 X 10(7), and 1.0 X 10(8) CFU were obtained when animals were simultaneously infected and treated with methotrexate, vincristine sulfate, or cytosine arabinoside, respectively.
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D003561:Cytarabine / Q000494:pharmacology; D005260:Female; D007109:Immunity; D007442:Intubation, Intratracheal; D007928:Lethal Dose 50; D008171:Lung Diseases / Q000276:immunology / Q000473:pathology; D008727:Methotrexate / Q000494:pharmacology; D051379:Mice; D011552:Pseudomonas Infections / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D014750:Vincristine / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D003561:Cytarabine; D014750:Vincristine; D008727:Methotrexate