The effects of methaqualone on the seizure susceptibility of mice.
Methaqualone produces dose- and time-dependent decreases in susceptibility to electrically, chemically, and sound-induced seizures. The antagonism of methaqualone to electroconvulsive shock can be dissociated from its effects on temperature regulation and plasma corticosterone. Studies with SKF525A, a drug known to block enzymes in the liver that metabolize drugs, suggest that methaqualone, rather than a metabolite produced in the liver, is responsible for its anticonvulsant effects. Tolerance to the anticonvulsant effects of methaqualone is also demonstrated.
D000161:Acoustic Stimulation; D000818:Animals; D000927:Anticonvulsants; D001831:Body Temperature / Q000187:drug effects; D003345:Corticosterone / Q000097:blood; D004361:Drug Tolerance; D004597:Electroshock; D008702:Methaqualone / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D011335:Proadifen / Q000494:pharmacology
D000927:Anticonvulsants; D008702:Methaqualone; D011335:Proadifen; D003345:Corticosterone; D010433:Pentylenetetrazole