Actinic keratoses treated with a combination of topical 5-fluorouracil and dinitrochlorobenzene.
A comparative study of topical 5-fluorouracil (5FU) alone and 5FU with dinitrochlorobenzene (DNCB) therapy in the treatment of actinic keratoses of the upper limbs is described. 5 out of 10 patients had better results with a combination of the two medications, while there was no difference in the results in 4 of the patients. Complications in the form of contact dermatitis to DNCB was experienced in 5 patients. Therapy of actinic keratoses of the upper limbs is recommended for a 6- to 8-week period with 5FU alone because of the difficulties associated with DNCB usage.
D000287:Administration, Topical; D001132:Arm; D003877:Dermatitis, Contact / Q000209:etiology; D004137:Dinitrochlorobenzene / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007642:Keratosis / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D009578:Nitrobenzenes / Q000627:therapeutic use*; D012867:Skin / Q000473:pathology
D004137:Dinitrochlorobenzene; D009578:Nitrobenzenes; D005472:Fluorouracil