title: [In vitro effect of fosfomycin against Pseudomonas aeruginosa compared to carbenicillin, gentamycin and polymyxin B].
abstract: The activity of fosfomycin against Pseudomonas aeruginosa (78 serotyped strains isolated from clinical specimens) is considerably more dependent on test conditions than that of carbenicillin, polymyxin B or gentamicin. Using a degree of standardization of the micro-serial dilution test and agar diffusion test (Iso-Sensitest broth and agar), which yields a high degree of correlation between the values of both techniques with carbenicillin and gentamicin, a moderate degree of correlation is obtained with fosfomycin. In regard to minimal inhibitory concentration (MIC) values in human serum and human urine, fewer "false" results are obtained in Iso-Sensitest broth than in Mueller Hinton broth and in particular glucose caseinhydrolysate broth. On the basis of MIC values in Iso-Sensitest broth P. aeruginosa is much more sensitive to polymyxin B, carbenicillin and gentamicin than to fosfomycin.
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002228:Carbenicillin / Q000494:pharmacology; D005578:Fosfomycin / Q000494:pharmacology*; D005839:Gentamicins / Q000494:pharmacology; D066298:In Vitro Techniques; D011112:Polymyxin B / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; D005578:Fosfomycin; D002228:Carbenicillin; D011112:Polymyxin B
vernacular_title: In-vitro-Wirksamkeit von Fosfomycin gegen Pseudomonas aeruginosa im Vergleich zu Carbenicillin, Gentamicin und Polymyxin B.