Cryptogenic cirrhosis associated with methyldopa.
A 55-year-old woman developed cirrhosis with portal hypertension while taking methyldopa. No other cause for the cirrhosis was evident. In view of the known hepatotoxic effects of methyldopa, a causal relationship is implied. Possible mechanisms of drug toxicity include both immunologic reactions and direct hepatocellular damage by the drug or its metabolites.
D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008103:Liver Cirrhosis / Q000139:chemically induced* / Q000473:pathology; D008750:Methyldopa / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged
D008750:Methyldopa