Thrombocytosis and platelet aggregates in the circulation of adjuvant arthritic rats.
A marked increase in platelet count was observed in adjuvant-induced polyarthritic rats. Elevation of platelet count was still significant 3 months after onset of disease. Increased number and larger size of platelets reflect an increase in the rate of platelet production. By means of the platelet-count ratio technique, circulating platelet aggregates were demonstrated in rats with severe arthritis. Aspirin treatment prevented thrombocytosis and formation of platelet aggregates.
D000818:Animals; D001168:Arthritis / Q000097:blood*; D001169:Arthritis, Experimental / Q000097:blood* / Q000188:drug therapy; D001241:Aspirin / Q000627:therapeutic use; D001772:Blood Cell Count; D001792:Blood Platelets / Q000473:pathology; D002452:Cell Count; D005620:Freund's Adjuvant; D008297:Male; D009169:Mycobacterium tuberculosis; D010974:Platelet Aggregation; D051381:Rats; D013922:Thrombocytosis / Q000209:etiology*
D005620:Freund's Adjuvant; D001241:Aspirin