Angiogenesis: a marker for neoplastic transformation of mammary papillary hyperplasia.
Mouse mammary papillomas elicit new formation of vessels when transplanted onto the rabbit iris. This angiogenic capacity is a property of carcinomas but not of the resting mammary gland. In mouse papillary hyperplasias, however, this property appears much earlier than any morphological or clinical sign of carcinoma. A test for angiogenic capacity may reveal a step in the progression toward clinical malignancy and thus could be used to screen for neoplastic potential of hyperplastic epithelium in biopsy tissues.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D005260:Female; D006965:Hyperplasia / Q000139:chemically induced / Q000473:pathology; D007498:Iris / Q000098:blood supply; D008325:Mammary Neoplasms, Experimental / Q000098:blood supply* / Q000139:chemically induced; D051379:Mice; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation; D010212:Papilloma / Q000098:blood supply*; D014183:Transplantation, Heterologous; D014520:Urethane
D014520:Urethane; D015127:9,10-Dimethyl-1,2-benzanthracene