The effect of age on IgE production in rats.
Inbred BN-rats were immunized at different ages with a standardized amount of ovalbumin and a1(OH)3. The specific IgE antibody response and total serum IgE levels were significantly influenced by age. The IgE antibody response increased to a maximum in 2-month-old rats and decreased progressively at a more advanced age. Total serum IgE levels increased progressively from the age of 1 month to the age of 5 months and decreased again at the age of one year.
D000375:Aging; D000818:Animals; D007117:Immunization, Secondary; D007073:Immunoglobulin E / Q000096:biosynthesis*; D051381:Rats; D011914:Rats, Inbred BN
D007073:Immunoglobulin E