title: [Testing the sterility of injection preparations of penicillin series antibiotics].
abstract: The efficiency of 3 variants of the method for determination of microbial flora was compared on the injection preparation of potassium benzylpenicillin artificially infected with Staph. aureus 209P and the spores of Bac. subtilis ATCC 6633 in different doses and with different amounts of the preparation in the vials. The procedure of the preparation dissolution in the vial with the thioglycol medium containing penicillinase proved to be most effective. The microbe detection amounted to 100 per cent. The procedure was less labour- and time-consuming since addition of penicillinase to each vial with the thioglycol medium was excluded. The risk of the medium occasional infection with microbial flora during the assay was decreased.
mesh_terms: D001412:Bacillus subtilis / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004340:Drug Contamination; D006018:Glycols; D007273:Injections, Intramuscular; D008722:Methods; D010400:Penicillin G / Q000494:pharmacology; D010406:Penicillins / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D006018:Glycols; D010406:Penicillins; D010400:Penicillin G
vernacular_title: K voprosu ispytaniia steril'nosti in'ektsionnykh preparatov antibiotikov penitsillinovogo riada.