Long-term actions of sulfonylureas on (pro-) insulin biosynthesis and secretion: I. Lack of evidence for a compensatory increase in (pro-) insulin biosynthesis after exposure of isolated pancreatic rat islets to tolbutamide and glibenclamide in vitro.
D000818:Animals; D005947:Glucose / Q000494:pharmacology; D005905:Glyburide / Q000494:pharmacology*; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects* / Q000378:metabolism; D011384:Proinsulin / Q000096:biosynthesis*; D051381:Rats; D013997:Time Factors; D014044:Tolbutamide / Q000494:pharmacology*
D007328:Insulin; D011384:Proinsulin; D014044:Tolbutamide; D005947:Glucose; D005905:Glyburide