[Environmental carcinogens: mechanisms of action and occurrence. Some aspects (author's transl)].
New aspects on the mechanism of action of known environmental carcinogens are described. These compounds are not active as such, but are bioactivated in the mammalian metabolism via chemically reactive intermediates to electrophilic reactants, forming with information-bearing biopolymeres covalent bonds. This change in the genetic code is in agreement with the mutation hypothesis of carcinogenesis. Aflatoxin B1, N-nitroso compounds and benzo(a)pyrene are taken as examples. "Threshold levels", e.g. no-effect-levels derived from animal experiments with all their inherent limitations, are compared with data from human exposure to benzo(a)pyren, aflatoxine, N-nitroso compounds and vinyl chloride. The difficulties of such risk evaluations are discussed.
D000348:Aflatoxins / Q000009:adverse effects; D000818:Animals; D002274:Carcinogens, Environmental / Q000378:metabolism / Q000494:pharmacology*; D004247:DNA / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D000882:Haplorhini; D006801:Humans; D008113:Liver Neoplasms / Q000139:chemically induced; D051379:Mice; D009154:Mutation; D009603:Nitroso Compounds / Q000009:adverse effects; D011083:Polycyclic Compounds / Q000302:isolation & purification; D051381:Rats; D014329:Tropical Climate; D014752:Vinyl Chloride / Q000009:adverse effects
D000348:Aflatoxins; D002274:Carcinogens, Environmental; D009603:Nitroso Compounds; D011083:Polycyclic Compounds; D004247:DNA; D014752:Vinyl Chloride
Umwelt-Karzinogene: Wirkmechanismen und Vorkommen. Einige Aspekte.