Inhibition of prostaglandin synthesis and leucocyte migration by flurbiprofen.
The carrageenan air pouch technique in the rat was used to investigate the effects of flurbiprofen, a non-steroidal anti-inflammatory agent, on prostaglandin production and leucocyte migration. tthere is a suggestion that flurbiprofen was capable of inhibiting prostaglandin synthesis at doses lower than those which were effective in reducing leucocyte migration. Therefore, these two effects may reflect independent actions of the drug. The possible clinical relevance of these experiments has been noted since the effects of flurbiprofen on prostaglandin synthesis and leucocyte migration are produced in the rat at peak plasma concentrations which are less than those found in man after a single dose of 50 mg.
D000818:Animals; D002351:Carrageenan; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D016861:Cyclooxygenase Inhibitors; D004305:Dose-Response Relationship, Drug; D005122:Exudates and Transudates / Q000166:cytology / Q000187:drug effects; D005480:Flurbiprofen / Q000494:pharmacology*; D008297:Male; D011422:Propionates / Q000494:pharmacology*; D011458:Prostaglandins E / Q000096:biosynthesis*; D051381:Rats
D016861:Cyclooxygenase Inhibitors; D011422:Propionates; D011458:Prostaglandins E; D005480:Flurbiprofen; D002351:Carrageenan