Mitochondrial biogenesis: inhibitors of mitochondrial protein synthesis.
The effects of erythromycin, chloramphenicol, cycloheximide, pyrimethamine, chromate, cadmium, lead, nickel, 4-nitro-quinoline-1-oxide and thioacetamide on yeast and human cells were studied. Inhibition of the synthesis of mitochondrial proteins resulted in the loss of cytochromes as well as in morphological changes in the cellular membranes and mitotic arrest. The data are discussed.
D015112:4-Nitroquinoline-1-oxide / Q000494:pharmacology; D002104:Cadmium / Q000494:pharmacology; D002701:Chloramphenicol / Q000494:pharmacology; D002840:Chromates / Q000494:pharmacology; D003513:Cycloheximide / Q000494:pharmacology; D003580:Cytochromes / Q000096:biosynthesis; D004917:Erythromycin / Q000494:pharmacology; D007854:Lead / Q000494:pharmacology; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D009532:Nickel / Q000494:pharmacology; D014176:Protein Biosynthesis / Q000187:drug effects*; D011739:Pyrimethamine / Q000494:pharmacology; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000378:metabolism*; D013053:Spectrophotometry; D013853:Thioacetamide / Q000494:pharmacology
D002840:Chromates; D003580:Cytochromes; D002104:Cadmium; D013853:Thioacetamide; D007854:Lead; D015112:4-Nitroquinoline-1-oxide; D004917:Erythromycin; D002701:Chloramphenicol; D009532:Nickel; D003513:Cycloheximide; D011739:Pyrimethamine