Thyroid activity in response to some gonadal steroids in methallibure-treated Heteropneustes fossilis (Bloch).
Methallibure treatment is as effective as hypophysectomy in reducing thyroid activity in H. fossilis. Sex steroids (TP and EB) administration restored thyroid activity in methallibure-treated females to normal level, but failed to elicit any response in males. This drug seems to block TSH secretion and thyroid hormone synthesis in H. fossilis.
D000818:Animals; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D005399:Fishes / Q000502:physiology*; D007016:Hypophysectomy; D008297:Male; D008693:Methallibure / Q000494:pharmacology*; D013739:Testosterone / Q000494:pharmacology; D013890:Thiourea / Q000031:analogs & derivatives*; D013961:Thyroid Gland / Q000378:metabolism*; D013963:Thyroid Hormones / Q000096:biosynthesis; D013972:Thyrotropin / Q000494:pharmacology
D013963:Thyroid Hormones; D013739:Testosterone; D004958:Estradiol; D013972:Thyrotropin; D013890:Thiourea; D008693:Methallibure