[Strophanthin sensitivity in disorders of cardiac blood supply, altered immunologic reactivity and under the influence of several pharmacologic agents].
Tests conducted with 125 cats demonstrated that occlusion of the coronary artery causes a higher sensitivity to the bathmotropic action of strophanthin, but does not have any effect on the magnitude of its lethal dose. The efficaciousness of potassium orotate and also of Na2EDTA in combinations with anapriline and isadrine, as regulators of the sensitivity to the toxic effect of strophanthin, was investigated. Immunization of cats with a homocardiac antigen was found to produce biphasic changes in the sensitivity to the toxic effect of strophanthin associated with the duration of antigenic stimulation.
D000818:Animals; D002415:Cats; D003327:Coronary Disease / Q000150:complications; D004492:Edetic Acid / Q000008:administration & dosage; D007114:Immunization; D007545:Isoproterenol / Q000008:administration & dosage; D009206:Myocardium / Q000276:immunology; D009963:Orotic Acid / Q000008:administration & dosage; D011433:Propranolol / Q000008:administration & dosage; D013328:Strophanthins / Q000037:antagonists & inhibitors / Q000633:toxicity*
D013328:Strophanthins; D009963:Orotic Acid; D004492:Edetic Acid; D011433:Propranolol; D007545:Isoproterenol
Chuvstvitel'nost' k strofantinu pri narushennom krovosnabzhenii miokarda, izmenennoĭ immunologicheskoĭ reaktivnosti i pod vliianiem nekotorykh farmakologicheskikh sredstv