Ionized calcium and magnesium: the effect of septic shock in the baboon.
Ionized calcium (Ca2+) and ionized magnesium (Mg2+) are important intracellular "second messengers" and control exictation-contraction coupling, excitation-secretion, oxidative phosphorylation, and mitochondrial acid-base balance. The present study examines the effect of septic shock on serum (Ca2+) and (Mg2+). Five adult female baboons were subjected to live E. coli septic shock and then resuscitated. Three baboons served as controls. Ca2+ was measured by the Orion SS-20 flow-through calcium electrode and Mg2+ calculated by the method of Killen. Other measurements included: total calcium, bound calcium, total magnesium, bound magnesium, phosphate, albumin, globulin, hemotocrit, and total protein. This study shows that there are significant disturbances of Ca2+ and Mg2+ during septic shock in the baboon. These disturbances may in part explain cellular dysfunction during shock including: decreased myocardial contractility, inappropriate secretion of endocrine cells, decrease in oxidative phosphorylation, and mitochondrial acidosis.
D000818:Animals; D002118:Calcium / Q000097:blood*; D000882:Haplorhini; D008274:Magnesium / Q000097:blood*; D010215:Papio; D012151:Resuscitation; D012709:Serum Albumin / Q000032:analysis; D012772:Shock, Septic / Q000097:blood*
D012709:Serum Albumin; D008274:Magnesium; D002118:Calcium