Identification of urinary catechol and methylated catechol metabolites of phenytoin in  humans, monkeys, and dogs by GLC and GLC-mass spectrometry.
A catechol metabolite, 5-(3,4-dihydroxyphenyl)-5-phenylhydantoin, and a methylated catechol metabolite, 5-(3-methoxy-4-hydroxyphenyl)-5-phenylhydantoin, were identified as urinary metabolites in humans, monkeys, and dogs following the administration of phenytoin. These metabolites were separated from each other and from other known metabolites of phenytoin as n-butyl derivatives by GLC and positively identified by combined GLC-mass spectrometry.
D000818:Animals; D001711:Biotransformation; D002396:Catechols / Q000652:urine*; D002849:Chromatography, Gas; D004285:Dogs; D000882:Haplorhini; D006801:Humans; D008253:Macaca mulatta; D008297:Male; D013058:Mass Spectrometry; D010672:Phenytoin / Q000378:metabolism*
D002396:Catechols; D010672:Phenytoin