Indolizine derivatives with biological activity IV: 3-(2-Aminoethyl)-2-methylindolizine, 3-(2-aminoethyl)-2-methyl-5,6,7,8-tetrahydroindolizine, and their N-alkyl derivatives.
In a continuing search for new biologically active agents derived from indolizine, 3-(2-aminoethyl)-2-methylindolizine, 3-(2-aminoethyl)-2-methyl-5,6,7,8-tetrahydroindolizine, and some mono- and di-N-substituted derivatives were prepared. Initial pharmacological screening showed that these compounds possess anti-5-hydroxytryptamine, antihistamine, antiacetylcholine, and CNS-depressant activities.
D000109:Acetylcholine / Q000037:antagonists & inhibitors; D000818:Animals; D002492:Central Nervous System Depressants / Q000138:chemical synthesis; D005260:Female; D006168:Guinea Pigs; D006633:Histamine Antagonists / Q000138:chemical synthesis; D066298:In Vitro Techniques; D007212:Indolizines / Q000138:chemical synthesis* / Q000494:pharmacology; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D051381:Rats; D012702:Serotonin Antagonists / Q000138:chemical synthesis
D002492:Central Nervous System Depressants; D006633:Histamine Antagonists; D007212:Indolizines; D012702:Serotonin Antagonists; D000109:Acetylcholine