Effects of gamma-aminobutyric acid and histamine on prolactin secretion in the rat.
Histamine releases prolactin (PRL) in estrogen-progesterone primed male rats after both iv and intracisternal (ic) injection, but does not affect in vitro PRL secretion. This stimulatory effect is reversed by the alpha-adrenergic antagonist phenoxybenzamine and the histamine antagonist diphenhydramine, gamma-Amino butyric acid (GABA), which has little in vivo effect of its own, interferes with the activity of histamine and a variety of other stimulators of PRL secretion. These results suggest the involvement of the naturally-occurring substances histamine and GABA in the central regulation of PRL secretion.
D000613:Aminobutyrates / Q000494:pharmacology*; D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D002478:Cells, Cultured; D003000:Clonidine / Q000494:pharmacology; D004155:Diphenhydramine / Q000494:pharmacology; D004298:Dopamine / Q000494:pharmacology; D004347:Drug Interactions; D004967:Estrogens / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology; D006632:Histamine / Q000494:pharmacology*; D008297:Male; D009020:Morphine / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D009419:Nerve Tissue Proteins / Q000494:pharmacology; D010643:Phenoxybenzamine / Q000494:pharmacology; D010902:Pituitary Gland / Q000187:drug effects* / Q000378:metabolism; D011374:Progesterone / Q000494:pharmacology; D011388:Prolactin / Q000097:blood / Q000378:metabolism*; D051381:Rats; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D000613:Aminobutyrates; D004967:Estrogens; D009419:Nerve Tissue Proteins; D010643:Phenoxybenzamine; D009270:Naloxone; D011374:Progesterone; D005680:gamma-Aminobutyric Acid; D013973:Thyrotropin-Releasing Hormone; D009020:Morphine; D006632:Histamine; D004155:Diphenhydramine; D011388:Prolactin; D006220:Haloperidol; D003000:Clonidine; D004298:Dopamine; D001640:Bicuculline