title: [Iron or combined iron-folic acid-vitamin B12 therapy during pregnancy? (author's transl)].
abstract: 128 women with mild anemias below 12 g% Hb received 100 mg iron or 100 mg iron, 0.44 mg folic acid and 0.66 mg vitamin B12 daily from the 20th to the 24th weeks of pregnancy until confinement. With pure iron therapy the maternal hemoglobin, erythrocyte, hematocrit and serum levels rose significantly, whereas in the placebo group (37 pregnant women) they fell markedly. Iron-folic acid-vitamin B12 administration led to no improvement in the hemoglobin regeneration or in the serum iron. After 60 days' treatment with the combined iron preparation, a rise in the serum and erythrocyte folate levels had already been achieved in the pregnancy women.
mesh_terms: D000747:Anemia, Hypochromic / Q000188:drug therapy*; D004338:Drug Combinations; D004912:Erythrocytes; D005260:Female; D005312:Fetal Blood / Q000032:analysis; D005492:Folic Acid / Q000097:blood / Q000627:therapeutic use*; D006454:Hemoglobins; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D007501:Iron / Q000009:adverse effects / Q000378:metabolism / Q000627:therapeutic use*; D010919:Placebos; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000188:drug therapy*; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D011446:Prospective Studies; D014805:Vitamin B 12 / Q000627:therapeutic use*
chemical_list: D004338:Drug Combinations; D006454:Hemoglobins; D010919:Placebos; D005492:Folic Acid; D007501:Iron; D014805:Vitamin B 12
vernacular_title: Eisen oder kombinierte Eisen-Folsäure-Vitamin-B12-Behandlung in der Schwangerschaft?