A case of lambda type tetramer Bence-Jones proteinemia.
A 50-year-old woman was found to have an extramedullary plasmacytoma of the thoracic vertebrae and a bone marrow plasmacytosis of 72%. In the serum of this myeloma patient, M-bow percipitin line was seen only with anti-lambda chain serum, but not with antisera against mu, alpha, gamma, delta, ipsilon and kappa chains. Gel filtration of the serum on the Sephadex G-200 column demonstrated the monoclonal lambda chain in the A-fraction along with transferrin and suggests a molecular weight of 88,000 and a tetrameric light chain. Bence-Jones protein has never been detected in the patient's urine.
D001536:Bence Jones Protein / Q000097:blood*; D002850:Chromatography, Gel; D005260:Female; D006801:Humans; D007146:Immunoglobulin lambda-Chains / Q000032:analysis; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood*; D013125:Spinal Neoplasms / Q000097:blood
D007146:Immunoglobulin lambda-Chains; D001536:Bence Jones Protein