[Role of planar cobalt chelate complexes as shunting agents in the electron transport chain of mitochondria].
It was shown that planar cobalt chelate complexes catalyze oxidation of NADH and hexahydroubiquinole Q4H2 by air oxygen. The most active agent--perchlorate of the cobalt complex 1, 2, 3, 7, 8, 12, 13, 17, 18, 19-decamethyloctadehydrocorrin--is capable of shunting the electron transfer chain of rat liver mitochondria and beef heart submitochondrial particles, catalyzing electron transfer from CoQ directly to the oxygen.
D000818:Animals; D002417:Cattle; D002614:Chelating Agents / Q000494:pharmacology; D003035:Cobalt / Q000494:pharmacology*; D004579:Electron Transport; D007700:Kinetics; D008928:Mitochondria / Q000378:metabolism*; D008929:Mitochondria, Heart / Q000187:drug effects / Q000378:metabolism*; D010084:Oxidation-Reduction; D013367:Submitochondrial Particles / Q000187:drug effects / Q000378:metabolism*
D002614:Chelating Agents; D003035:Cobalt
Ploskie khelatnye kompleksy kobal'ta kak shuntiruiushchie agenty v elektrontransportnoĭ tsepi mitokhondriĭ.