title: [Pathogenicity of aerobically sporulating microorganisms: Bacillus subtilis].
abstract: Bioassays were made on white mice and rats to find the potential pathogenicity of B. subtilis and its metabolites. The peroral and intraperitoneal application of several strains of B. subtilis to white mice did not cause any changes either in the behaviour or health condition of the animals until the first to seventh day after test. B. subtilis cultures or cellular suspensions on the one hand and non-cellular filtrates of cultures represented by the B. subtilis metabolism products on the other hand were given to the animals. No changes in the health condition of the mice and rats were observed when feed artificially infected with B. subtilis was fed. Dissection did not reveal any macroscopic changes on the organs of the abdominal and thoracic cavity. Cultures from the individual body organs (liver, spleen, kidneys, parts of the small and large intestines, stomach) perorally infected with B. subtilis showed the presence of the microbe only in parts of the digestive tracts.
mesh_terms: D000332:Aerobiosis; D000818:Animals; D001412:Bacillus subtilis / Q000472:pathogenicity*; D001681:Biological Assay; D003470:Culture Media; D005516:Food Microbiology; D051379:Mice; D051381:Rats; D013171:Spores, Bacterial
chemical_list: D003470:Culture Media
vernacular_title: Patogenita aerobnĕ sporulujících mikcroorganismú: Bacillus subtilis.