[Primary liver carcinoma: deficiency of alpha 1-antitrypsin].
A preliminary study involving 12 subjects suffering from carcinoma of the liver indicates the value of the estimation of alpha-1 antitrypsin and the determination of its phenotype by bidimensional electrophoresis. Alpha-1 antitrypsin was greater than 3.3 g/l in all cases, with a normal of 2.5 g/l. The MZ phenotype was found in 9 cases out of 12, the MM phenotype in the three recent cases and in particular in the only case of secondary carcinoma. In the Pi system, the Z trait would seem to be a genetic risk factor in primary carcinoma of the liver. Determination of the phenotype of alpha-1 antitrypsin may aid in its laboratory diagnosis.
D006514:Hepatitis B Surface Antigens / Q000302:isolation & purification; D006801:Humans; D005779:Immunodiffusion; D008113:Liver Neoplasms / Q000150:complications*; D010641:Phenotype; D019896:alpha 1-Antitrypsin Deficiency
D006514:Hepatitis B Surface Antigens
Cancer primitif du foie: incidence du déficit en alpha-1-antitrypsine.