[Ultrastructure of "villose cells" in the early stages of their formation in the process of chemical carcinogenesis in the CNS].
Early stages of redistribution of cellular elements around the pill of carcinogenic agent DMBA introduced into the right hemisphere of the brain of female SHK albino rats were studied. Precursors of the ciliated cells were established to appear in the perivascular tissue within 12 h. Within 24 h they accumulate around the pill bed, and within 48 h a cellular edging is formed around DMBA. The cytoplasm of ciliated cells become richer in organelles. The main marker in identification of cells in all periods of experiment were lipoid inclusions in the cytoplasm which are different from lipids of usual macrophages occurring both in experiments and in control, in a polygonal shape and sinuous contour. Within 48 h the cytoplasm of ciliated cells form long lancet-shaped spiculae with upright walls. The cytoplasm of macrophages gives only short, somewhat sinuous processes.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D001932:Brain Neoplasms / Q000139:chemically induced / Q000648:ultrastructure*; D005260:Female; D008264:Macrophages / Q000648:ultrastructure*; D051381:Rats
D015127:9,10-Dimethyl-1,2-benzanthracene
Ul'trastruktura "vorsinchatykh kletok" na rannikh étapakh ikh formirovaniia v protsesse khimicheskogo kantserogeneza v TsNS.