Spiro[isobenzofuran-1(3H),4'-piperidines]. 3. Diuretic and antihypertensive properties of compounds containing a sulfur attached to nitrogen.
The synthesis and antihypertensive and diuretic activity of several N-sulfur derivatives of 3-phenylspiro[isobenzofuran-1(3H),4'-piperidine] are reported. Benzenesulfenamide 3 possessed marked, species-specific diuretic and antihypertensive activity in rats.
D000818:Animals; D000928:Antidepressive Agents / Q000138:chemical synthesis; D000959:Antihypertensive Agents / Q000138:chemical synthesis*; D002490:Central Nervous System / Q000187:drug effects; D003864:Depression, Chemical; D004232:Diuretics / Q000138:chemical synthesis*; D004285:Dogs; D005260:Female; D000882:Haplorhini; D006973:Hypertension / Q000503:physiopathology; D008253:Macaca mulatta; D010880:Piperidines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D012964:Sodium / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000928:Antidepressive Agents; D000959:Antihypertensive Agents; D004232:Diuretics; D010880:Piperidines; D012964:Sodium