Sister chromatid exchange and chromosome aberration analysis with the use of several carcinogens and noncarcinogens.
Several chemical carcinogens and noncarcinogens were tested for their ability to induce sister chromatid exchanges (SCE) and structural chromosome aberrations in cultured V79-4 Chinese hamster cells. All of the direct-acting carcinogens induced a large increase in SCE frequency. Two chemicals, which are mutagenic in microorganisms but whose carcinogenicity is poorly documented, also increased the frequency of SCE. Carcinogenic polycyclic hydrocarbons caused an increased incidence of SCE only when a metabolizing feeder layer was used, whereas no increase was observed with noncarcinogenic polycyclic hydrocarbons. The other noncarcinogens also did not influence the SCE frequency. Although some chemicals increased the frequency of structural chromosome aberrations, no correlation was found between the frequencies of SCE and aberrations.
D015073:2-Acetylaminofluorene / Q000494:pharmacology; D015112:4-Nitroquinoline-1-oxide / Q000494:pharmacology; D015127:9,10-Dimethyl-1,2-benzanthracene / Q000494:pharmacology; D000166:Acridines / Q000494:pharmacology; D001580:Benzopyrenes / Q000494:pharmacology; D002273:Carcinogens / Q000494:pharmacology*; D002460:Cell Line; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects*; D004353:Drug Evaluation, Preclinical; D006918:Hydroxyurea / Q000494:pharmacology; D008748:Methylcholanthrene / Q000494:pharmacology; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology; D010616:Phenanthrenes / Q000494:pharmacology; D011083:Polycyclic Compounds / Q000494:pharmacology; D011721:Pyrenes / Q000494:pharmacology
D000166:Acridines; D001580:Benzopyrenes; D002273:Carcinogens; D010616:Phenanthrenes; D011083:Polycyclic Compounds; D011721:Pyrenes; D008769:Methylnitronitrosoguanidine; D008748:Methylcholanthrene; D015112:4-Nitroquinoline-1-oxide; D015127:9,10-Dimethyl-1,2-benzanthracene; D015073:2-Acetylaminofluorene; D006918:Hydroxyurea