Preparation and antidiabetic activity of some sulfonylurea derivatives of 3,5-disubstituted pyrazoles.
Four series of p-[3,5-dimethyl- (and 5-methyl-3-carboxy-) pyrazole-1]benzenesulfonylureas, thioureas, 2-thiohydantions, and 5,6-dihydro-4(3H)-oxo-2(1H)-pyrimidinethiones were prepared for evaluation as hypoglycemic agents. Biological testing of these compounds showed that some possessed antidiabetic activity.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D055598:Chemical Phenomena; D002621:Chemistry; D004347:Drug Interactions; D005260:Female; D007004:Hypoglycemic Agents / Q000138:chemical synthesis*; D051379:Mice; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D013453:Sulfonylurea Compounds / Q000138:chemical synthesis* / Q000494:pharmacology
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D011720:Pyrazoles; D013453:Sulfonylurea Compounds