Jimpy mouse myelin revisited with freeze-fracture.
Corpus callosum, cerebellum, and spinal cord from Jimpy mice, and control littermates, 15 and 21 days old, were prepared for freeze-fracture in a "cryofract" apparatus. The few myelinated axons in the Jimpy exhibited a striking paucity of particles in myelin P faces, though tight junctions were present. In addition, small maculae of particles were found on these P faces. Peripheral myelin appeared normal, both for the quantity and disposition of particles on their P faces.
D000818:Animals; D001369:Axons / Q000648:ultrastructure; D002531:Cerebellum / Q000032:analysis; D003337:Corpus Callosum / Q000032:analysis; D005614:Freeze Fracturing; D007365:Intercellular Junctions; D051379:Mice; D008816:Mice, Jimpy / Q000378:metabolism*; D008818:Mice, Neurologic Mutants / Q000378:metabolism*; D008855:Microscopy, Electron, Scanning; D009185:Myelin Proteins / Q000032:analysis*; D013116:Spinal Cord / Q000032:analysis
D009185:Myelin Proteins