Study of platelet aggregation in vivo: IV Effect of pyrimido-pyrimidine derivatives.
Two pyrimido-pyrimidine derivatives (RA 233  and VK 744) were found effective aggregation inhibitors in vitro of human and monkey platelets and in vivo in stumptailed monkeys and chimpanzees. They also inhibited thrombotic occlusion of metal screens inserted into arteriovenous shunts.
D000818:Animals; D000882:Haplorhini; D008251:Macaca; D009012:Mopidamol / Q000494:pharmacology*; D009025:Morpholines / Q000494:pharmacology*; D002679:Pan troglodytes; D010974:Platelet Aggregation / Q000187:drug effects*; D011743:Pyrimidines / Q000494:pharmacology*
D009025:Morpholines; D011743:Pyrimidines; C001572:VK 744; D009012:Mopidamol