Testicular testosterone concentration following testicular vein ligation.
A rat model to study the local effects of testicular vein ligation is described. One hour after unilateral testicular vein ligation, the testicular concentration of testosterone was significantly greater (P less than 0.01) on the side that was ligated than in the contralateral testis (177.1 +/- 19.7 [SEM] ng/gm of tissue as compared with 108.8 +/- 11.8 ng/gm of tissue, respectively). This effect was not seen 1 week after the testicular vein ligation. The testosterone concentration in the ligated testis was also higher than that in sham-operated animals. These differences in testicular testosterone concentration were not associated with changes in peripheral serum testosterone levels.


CONCLUSIONS
ligation of the testicular vein causes an acute rise in the testicular concentration of testosterone and may thus mediate changes in testicular function.
D000818:Animals; D008026:Ligation; D008297:Male; D008954:Models, Biological; D051381:Rats; D013737:Testis / Q000098:blood supply*; D013739:Testosterone / Q000378:metabolism*; D014680:Veins / Q000502:physiology
D013739:Testosterone