Effect of a quinazolinone derivative on the metabolism of Streptococcus faecalis--R (ATCC-8043).
2-methyl-3(3'-methyl-2'-pyridyl)-4 (3H) quinazolinone (SRC-820) and methaqualone inhibited the growth of Streptococcus faecalis-R (ATCC-8043). Phosphoenolpyruvate formation from 3-phosphoglycerate by an enzyme extract of S. faecalis was inhibited by SRC-820. With edetate or fluoride, an additive inhibitory effect by SRC-820 was observed.
D003864:Depression, Chemical; D013293:Enterococcus faecalis / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects; D011725:Pyridines / Q000494:pharmacology*; D011799:Quinazolines / Q000494:pharmacology*; D013997:Time Factors
D011725:Pyridines; D011799:Quinazolines