Mutagenicity of resin acids identified in pulp and paper mill effluents using the Salmonella/mammalian-microsome assay.
Ten resin acids which have been identified as constituents of pulp and paper mill effluents have been examined for potential mutagenicity in the Salmonella/mammalian-microsome assay. Only neoabietic acid has been found to be mutagenic. Neoabietic acid showed dose-related increases in mutagenicity in strains TA1535, TA100, TA1538, and TA98, but not in strain TA1537. Metabolic activation with a preparation of Aroclor 1254-induced liver homogenate (S9) slightly reduced the mutagenic responses. Negative responses were found for abietic acid, dehydroabietic acid, levopimaric acid, 7-oxodehydroabietic acid, monochlorodehydroabietic acid, dichlorodehydroabietic acid, pimaric acid, isopimaric acid, and sandaracopimaric acid.
D000143:Acids / Q000494:pharmacology; D007220:Industrial Waste; D009152:Mutagenicity Tests; D009153:Mutagens; D010209:Paper; D012117:Resins, Synthetic / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000235:genetics; D014874:Water Pollutants, Chemical / Q000032:analysis
D000143:Acids; D007220:Industrial Waste; D009153:Mutagens; D012117:Resins, Synthetic; D014874:Water Pollutants, Chemical