title: Biochemical and behavioural effects of hypoxic hypoxia in rats: study of the protection afforded by ergot alkaloids.
abstract: The conditioned avoidance response and the cerebral levels of dopamine and noradrenaline have been studied in control rats and in rats submitted to a hypobaric hypoxia. A protection against the effects of hypoxia was induced by both dihydroergocornine (20 microgram/kg) and dihydroergocryptine (100 microgram/kg), and the noradrenaline level did not decrease. This stabilization of cerebral noradrenaline level seems to be the main protection factor observed.
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001921:Brain / Q000378:metabolism; D002395:Catecholamines / Q000378:metabolism*; D004088:Dihydroergotoxine / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004877:Ergoloid Mesylates / Q000494:pharmacology*; D005260:Female; D002534:Hypoxia, Brain / Q000378:metabolism* / Q000517:prevention & control; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats
chemical_list: D002395:Catecholamines; D004088:Dihydroergotoxine; D004877:Ergoloid Mesylates; D004298:Dopamine; D009638:Norepinephrine