Surfactant in the amniotic fluid and bromhexine metabolite VIII.
The effect of metabolite VIII of bromhexine on surfactant content in the amniotic fluid was investigated in a double blind study. Administration of 100 and 200 mg NA-872 daily for 5 days to pregnant women ranging in gestational age from 196 to 243 days was not followed by a significant rise in the L/S ratio.
D000551:Ambroxol / Q000494:pharmacology*; D000653:Amniotic Fluid / Q000032:analysis*; D001964:Bromhexine / Q000031:analogs & derivatives*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D005865:Gestational Age; D006801:Humans; D007556:Isoxsuprine / Q000627:therapeutic use; D007752:Obstetric Labor, Premature / Q000517:prevention & control; D010713:Phosphatidylcholines / Q000032:analysis; D011247:Pregnancy; D011663:Pulmonary Surfactants / Q000032:analysis*; D013109:Sphingomyelins / Q000032:analysis
D010713:Phosphatidylcholines; D011663:Pulmonary Surfactants; D013109:Sphingomyelins; D000551:Ambroxol; D001964:Bromhexine; D007556:Isoxsuprine