Reversible defect of neutrophil chemotaxis and random migration in primary hyperparathyroidism.
Chemotactic and random migrations of neutrophils derived from four patients with primary hyperparathyroidism were found to be defective. These abnormalities improved significantly in parallel with the decrease in serum calcium and parathormone and with the increase in serum phosphorus concentration after surgical removal of the adenoma. These observation suggest a possible role for parathormone phosphorus and calcium in the motility of neutrophils.
D000293:Adolescent; D000328:Adult; D002118:Calcium / Q000097:blood; D002633:Chemotaxis; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000502:physiology*; D010281:Parathyroid Hormone / Q000097:blood; D010758:Phosphorus / Q000097:blood
D010281:Parathyroid Hormone; D010758:Phosphorus; D002118:Calcium