Induction of microsomal drug-metabolizing enzymes caused by hexobarbital.
Hexobarbital was given to anaesthetized mice for a period of 7 h by repeated i. p. injection, first of 100 mg/kg,then several times of 50 mg/kg. A high level of hexobarbital was maintained in the liver. The activity of microsomal drug-metabolizing enzymes was induced by this treatment with hexobarbital. 30 min after a single i. p. injection of 100 mg/kg of hexobarbital, there was a significant inhibition of aminopyrine N-demethylase but none of cytochrome c and neotetrazolium reductases. Hexobarbital in vitro inhibits aminopyrine N-demethylase but not cytochrome c reductase.
D000633:Aminopyrine N-Demethylase / Q000096:biosynthesis; D000818:Animals; D004790:Enzyme Induction / Q000187:drug effects*; D006591:Hexobarbital / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D009246:NADH Tetrazolium Reductase / Q000096:biosynthesis; D009251:NADPH-Ferrihemoprotein Reductase / Q000096:biosynthesis; D004364:Pharmaceutical Preparations / Q000378:metabolism*
D004364:Pharmaceutical Preparations; D006591:Hexobarbital; D000633:Aminopyrine N-Demethylase; D009246:NADH Tetrazolium Reductase; D009251:NADPH-Ferrihemoprotein Reductase