title: Meningococcus group A vaccine in children three months to five years of age. Adverse reactions and immunogenicity related to endotoxin content and molecular weight of the polysaccharide.
abstract: Vaccination of 21,007 children between the ages of three months and five years was completed with five different lots of the meningococcal group A capsular polysaccharide vaccine. A correlation was found between the frequency and severity of adverse reactions and the endotoxin content of the vaccine lots. All vaccine lots elicited a serum antibody response. The endotoxin content of the vaccines did not correlate with the serum antibody response.
mesh_terms: D000907:Antibodies, Bacterial; D000917:Antibody Formation; D001428:Bacterial Vaccines / Q000009:adverse effects*; D002675:Child, Preschool; D004731:Endotoxins / Q000009:adverse effects*; D006801:Humans; D007109:Immunity; D007223:Infant; D008970:Molecular Weight; D009345:Neisseria meningitidis / Q000276:immunology*; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D014611:Vaccination / Q000009:adverse effects*
chemical_list: D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D004731:Endotoxins; D011135:Polysaccharides, Bacterial