Acute intoxication with verapamil.
A healthy 18-year-old man was admitted to our unit two hours after a suicidal ingestion of 2 gm of verapamil. There was mild hypotension, depression of the sinus node, atrioventricular dissociation, changes of repolarization, and first-degree intranodal atrioventricular block (the His bundle electrogram revealed an atrio-His [A-H] interval of 155 msec). Twenty-four hours after ingestion, the patient was well, and the electrocardiogram was completely normal. This case gave us a good opporturnity to study the electrocardiologic effects of a huge oral dose of verapamil on a healthy young heart.
D000284:Administration, Oral; D000293:Adolescent; D001283:Atrioventricular Node / Q000187:drug effects; D004562:Electrocardiography; D006321:Heart / Q000187:drug effects*; D006327:Heart Block / Q000139:chemically induced* / Q000503:physiopathology; D006329:Heart Conduction System / Q000187:drug effects / Q000503:physiopathology; D006801:Humans; D008297:Male; D013406:Suicide, Attempted; D014700:Verapamil / Q000008:administration & dosage / Q000506:poisoning*
D014700:Verapamil