Role of protein binding and pharmacokinetics in the lack of correlation between in vitro inhibition of PG-synthetase and in vivo antiinflammatory activity of a homologous series of nonsteroidal antiinflammatory compounds.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000097:blood / Q000494:pharmacology*; D001095:Arachidonic Acids / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism; D002417:Cattle; D016861:Cyclooxygenase Inhibitors; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D006899:Mixed Function Oxygenases / Q000037:antagonists & inhibitors*; D011458:Prostaglandins E / Q000096:biosynthesis; D011485:Protein Binding; D051381:Rats; D012669:Seminal Vesicles / Q000201:enzymology; D012995:Solubility
D000893:Anti-Inflammatory Agents; D001095:Arachidonic Acids; D001798:Blood Proteins; D016861:Cyclooxygenase Inhibitors; D011458:Prostaglandins E; D006899:Mixed Function Oxygenases