Effect of 1-(2,4-dichlorobenzyl)-indazole-3-carboxylic acid on sperm tails in rhesus monkeys.
Large numbers of spermatozoa with bent or coiled tails were found in the ejaculates of rhesus monkeys treated with 1-(2,4-dichlorobenzyl-indazole-3-carboxylic acid (DICA) (50 or 500 mg/kg for various periods). The defect appeared only in spermatozoa in the cauda epididymidis and consisted of axoneme disarrangement and loss of the fibre doublets. The coil was completely enclosed in a membrane.
D000818:Animals; D005298:Fertility / Q000187:drug effects; D000882:Haplorhini; D007191:Indazoles / Q000494:pharmacology*; D008253:Macaca mulatta; D008297:Male; D008854:Microscopy, Electron; D011720:Pyrazoles / Q000494:pharmacology*; D013082:Sperm Tail / Q000187:drug effects* / Q000648:ultrastructure; D013094:Spermatozoa / Q000187:drug effects*
D007191:Indazoles; D011720:Pyrazoles