Antifertility effects of the steroid 5 alpha-stigmastane-3 beta, 5, 6 beta-triol 3-monobenzoate on mice.
The steroid 5 alpha-stigmastane-3 beta, 5, 6 beta-triol 3-monobenzoate at a dose of 40 mg/kg of body weight has 100% interceptive activity when administered orally in a single dose during 6-7 days of gestation but it has no action on pregnancy if treated on 10th, 13th or 16th day of pregnancy. The interceptive activity of the steroid is lost by simultaneous injection of prolactin, progesterone or LH.
D000019:Abortifacient Agents / Q000008:administration & dosage*; D000021:Abortifacient Agents, Steroidal / Q000008:administration & dosage*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D005298:Fertility / Q000187:drug effects*; D051379:Mice; D013261:Sterols / Q000008:administration & dosage*; D013997:Time Factors
D000019:Abortifacient Agents; D000021:Abortifacient Agents, Steroidal; D013261:Sterols