title: Labyrinth and cerebral-spinal fluid pressure changes in guinea pigs and monkeys during simulated zero G.
abstract: This study was undertaken to explore the hypothesis that shifts of body fluids from the legs and torso toward the head contribute to the motion sickness experienced by astronauts and cosmonauts. The shifts in body fluids observed during zero-G exposure were simulated by elevating guinea pigs' and monkeys' torsos and hindquarters. Cerebral-spinal fluid pressure was recorded from a transducer located in a brain ventricle; labyrinth fluid pressure was recorded from a pipette cemented in a hole in a semicircular canal. An anticipated divergence in cerebral-spinal fluid pressure and labyrinth fluid pressure during torso elevation was not observed. The results of this study do not support a fluid shift mechanism of zero-G-induced motion sickness. However, a more complete test of the fluid shift mechanism would be obtained if endolymph and perilymph pressure changes were determined separately; we have been unable to perform this test to date.
mesh_terms: D000818:Animals; D001826:Body Fluids / Q000502:physiology; D002555:Cerebrospinal Fluid / Q000502:physiology*; D006112:Gravitation; D006168:Guinea Pigs; D000882:Haplorhini; D007761:Labyrinthine Fluids / Q000502:physiology*; D008253:Macaca mulatta; D009041:Motion Sickness / Q000503:physiopathology; D011187:Posture; D011312:Pressure; D013997:Time Factors