title: Seizure severity and acquisition and performance of operant tasks in a monkey model.
abstract: Several studies utilizing an alumina-gel monkey model demonstrated a relationship between degree of epileptic activity and learning difficulty. Three operant tasks were employed: single-unit, gross-motor positive reinforcement, and avoidance conditioning. The data indicated that the number of hours needed to learn any one of the tasks increased with seizure frequency and/or number of EEG interictal bursts. The learning impairment appeared to be a function of the relevance of the required response to the site of the epileptogenic focus.
mesh_terms: D000818:Animals; D001362:Avoidance Learning; D003216:Conditioning, Operant; D000882:Haplorhini; D008253:Macaca mulatta; D012054:Reinforcement, Psychology; D012640:Seizures; D013647:Task Performance and Analysis