Carbohydrate and lipid studies in women using the progesterone intrauterine device for one year.
Carbohydrate and lipid metabolism was evaluated in 31 women before and after 1 year's use of a progesterone-releasing intrauterine device. The studies involved measuring blood glucose and plasma insulin levels during a 3-hour oral glucose tolerance test and also measuring fasting cholesterol and triglyceride levels. There was no change in the cholesterol levels, whereas the triglyceride concentration was lower at the 1-year test. The blood glucose values were unchanged at four of the time periods, whereas the 3-hour value was elevated at the 1-year test. The plasma insulin values were increased in the fasting, 0.5-, and 3-hour samples at the 1-year test. The increased insulin secretion needed to maintain the blood glucose concentration suggests that the released progesterone may have a systemic effect.
D000328:Adult; D002241:Carbohydrates / Q000097:blood*; D002784:Cholesterol / Q000097:blood; D005215:Fasting; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D007436:Intrauterine Devices, Medicated; D008055:Lipids / Q000097:blood*; D011374:Progesterone / Q000008:administration & dosage*; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
D002241:Carbohydrates; D007328:Insulin; D008055:Lipids; D014280:Triglycerides; D011374:Progesterone; D002784:Cholesterol