Genetic rescue of a lethal "null" activity allele of 6-phosphogluconate dehydrogenase in Drosophila melanogaster.
While a null activity mutant allele of the structural gene for 6-phosphogluconate dehydrogenase in Drosophila melanogaster is lethal, a similar mutation for glucose-6-phosphate dehydrogenase is not. Double mutant combinations lacking both enzyme activities, obtained either by recombination or by mutagen treatment of a chromosome bearing the lethal allele, result in a restoration of viability. The indispensability of the pentose phosphate shunt in Drosophila appears to depend upon the specific position of the block within the pathway.
D000483:Alleles; D000818:Animals; D004331:Drosophila melanogaster / Q000201:enzymology* / Q000378:metabolism; D005796:Genes; D005804:Genes, Lethal; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000235:genetics*; D009154:Mutation; D010428:Pentosephosphates / Q000378:metabolism; D010734:Phosphogluconate Dehydrogenase / Q000172:deficiency*
D010428:Pentosephosphates; D010734:Phosphogluconate Dehydrogenase