Interferon enhances the fragility of lysosomes in L-929 mouse fibroblasts.
Infection of interferon-treated L-929 mouse fibroblasts with vaccinia WR virus is followed by severe cytolysis within 3 to 4 h. It is shown that this cytolysis cannot be caused by enzymes released from lysosomes into the cytosol. However, there is evidence that homologous interferon has a noxious effect on lysosomes. This phenomenon appears to be another aspect of the anticellular functions of interferon.
D000818:Animals; D003588:Cytopathogenic Effect, Viral; D003851:Deoxyribonucleases / Q000378:metabolism; D005966:Glucuronidase / Q000378:metabolism; D007372:Interferons / Q000494:pharmacology*; D007739:L Cells; D008247:Lysosomes / Q000187:drug effects* / Q000201:enzymology; D051379:Mice; D014616:Vaccinia virus / Q000254:growth & development*; D001616:beta-Galactosidase / Q000378:metabolism
D007372:Interferons; D003851:Deoxyribonucleases; D001616:beta-Galactosidase; D005966:Glucuronidase