title: Absence of tight junctions in endothelium of marrow sinuses: possible significance for marrow cell egress.
abstract: The nature of contact between endothelial cells in rat marrow sinuses was studied. Colloidal lanthanum permeated freely into the interendothelial space. Moreover, using freeze-fracture technique, we failed to show junctional structures where these endothelial cells came into contact. With thin sectioning electron microscopy, we observed occasional submembranous densities but the interendothelial distance measured 20 nm and no membrane fusion was seen. Absence of tight junctions between endothelial cells of marrow sinuses may serve a function in marrow cell egress by permitting these cells to slide over each other, thereby changing the luminal size. Within the fixed volume of marrow, an increase in luminal size results in displacement of haemopoietic cells into the lumen.
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000648:ultrastructure*; D004727:Endothelium / Q000648:ultrastructure; D005614:Freeze Fracturing; D007365:Intercellular Junctions / Q000648:ultrastructure*; D008297:Male; D051381:Rats