Light and electron microscopic studies of thyrotrophin releasing hormone-induced growth hormone and prolactin release in hypophysectomized rats bearing an ectopic pituitary gland.
A light microscopic and ultrastructural study of anterior pituitary glands transplanted under the kidney capsule of hypophysectomized rats was performed, in basal conditions and after stimulation with thyrotrophin releasing hormone, at various intervals (24 h-2 months) after transplantation. Confirming previous biochemical findings, the results suggest that with time, somatotrophs acquire sensitivity to thyrotrophin releasing hormone and respond with increased exocytosis at doses that were found ineffective in pituitary glands in situ. Thyrotrophin releasing hormone stimulation did not seem to influence the morphology of prolactin cells, which were already highly active under basal conditions at all time intervals.
D000818:Animals; D005089:Exocytosis / Q000187:drug effects; D005260:Female; D013006:Growth Hormone / Q000378:metabolism; D007016:Hypophysectomy; D010902:Pituitary Gland / Q000648:ultrastructure*; D010903:Pituitary Gland, Anterior / Q000187:drug effects / Q000637:transplantation / Q000648:ultrastructure*; D011388:Prolactin / Q000378:metabolism; D051381:Rats; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*; D013997:Time Factors; D014184:Transplantation, Homologous
D013973:Thyrotropin-Releasing Hormone; D011388:Prolactin; D013006:Growth Hormone