Stability of cephalosporins in horse serum.
The antibiotic activity of cephalothin, cephaloridine, cephalexin, cephaloglycin, cefazolin, and cefamandole was determined after storage for up to 30 days in horse serum at -10 and 4 degrees C. Cephalothin, cefamandole, cefazolin, and cephalexin were stable for at least 30 days at -10 degrees C, whereas cephaloridine lost 29% of its initial activity and cephaloglycin lost more than 50%. Cefamandole, cefazolin, and cephalexin could only be stored for 3 days at 4 degrees C without significant loss in activity, whereas cephalothin, cephaloridine, and cephaloglycin could be stored for only 1 day. Repeated freezing and thawing had a detrimental effect on the stability of cephaloridine.
D000818:Animals; D001412:Bacillus subtilis / Q000187:drug effects; D001769:Blood; D002511:Cephalosporins / Q000494:pharmacology*; D003470:Culture Media; D004355:Drug Stability; D006736:Horses; D012505:Sarcina / Q000187:drug effects; D013696:Temperature
D002511:Cephalosporins; D003470:Culture Media