Comparative evaluation of human leukocyte and fibroblast interferon in the prevention of herpes simplex virus keratitis in a monkey model.
The prophylactic potency of topically applied human leukocyte interferon and human fibroblast interferon was compared in a monkey model with herpes simplex virus type 1-induced keratitis. Both interferons effectively prevented keratitis at 1.9 X 10(6) U of activity per ml but were ineffective at 1.9 X  10(3) U/ml. Slight differences between human leukocyte interferon and human fibroblast interferon observed at the level of 1.9 X 10(5) U/ml were not statistically significant.
D000818:Animals; D046508:Culture Techniques; D004195:Disease Models, Animal; D005347:Fibroblasts / Q000378:metabolism; D000882:Haplorhini; D006801:Humans; D007372:Interferons / Q000009:adverse effects / Q000096:biosynthesis / Q000627:therapeutic use*; D007635:Keratitis, Dendritic / Q000517:prevention & control*; D007962:Leukocytes / Q000378:metabolism
D007372:Interferons