[Effect of thiamine on the activity of liver endoplasmic reticulum enzymes metabolizing drugs].
Experiments on mongrel albino male rats have shown that a single subcutaneous administration of thiamine in a dose of 200 mg/kg raises in the liver microsomes the level of cytochromes P-450 and B5 and increases the activity of aniline-n-hydroxylase ethylmorphine and aminopyrine-N-demethylase. Administration of the vitamin in a dose of 30 mg/kg for 64 days forces down the cytochrome P-450 and the aniline-n-hydroxylase and ethylmorphine-N-demethylase levels. In vitro tests the P-450 and B5 cytocrome levels and the activity of ethylmorphine-N-demethylase in the liver microsomes start to decrease at the thiamine concentration of 1 mM and of aminopyrine-N-demethylase of 4 mM.
D000633:Aminopyrine N-Demethylase / Q000378:metabolism; D000818:Animals; D001711:Biotransformation / Q000187:drug effects; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D003580:Cytochromes / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004721:Endoplasmic Reticulum / Q000187:drug effects / Q000201:enzymology; D005037:Ethylmorphine-N-Demethylase / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D051381:Rats; D013831:Thiamine / Q000494:pharmacology*
D003580:Cytochromes; D003577:Cytochrome P-450 Enzyme System; D000633:Aminopyrine N-Demethylase; D005037:Ethylmorphine-N-Demethylase; D013831:Thiamine
Deĭstvie tiamina na aktivnost' fermentov éndoplazmaticheskogo retikuluma pecheni, metaboliziruiushchikh lekarstvennye veshchestva.