Appearance of a variant of MOPC 104E which does not react with dextran B-1355s.
MOPC 104E is a mouse plasmacytoma which produces an IgM (lambda) myeloma protein. This IgM protein has a binding specificity for dextran B-135s. This report describes a variant of the MOPC 104E tumor which secretes a myeloma protein which does not react with the dextran. The apparent variant of MOPC 104E arose spontaneously during routine passage of the MOPC 104E tumors in Balb/C mice and appears to be stable.
D000818:Animals; D002846:Chromatography, Affinity; D003911:Dextrans / Q000494:pharmacology*; D014644:Genetic Variation; D005779:Immunodiffusion; D007164:Immunosorbents / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D009194:Myeloma Proteins / Q000302:isolation & purification; D010954:Plasmacytoma / Q000276:immunology*
D003911:Dextrans; D007164:Immunosorbents; D009194:Myeloma Proteins