[Studies in the BALB/c mouse of the efficiency of spraying as compared to other inoculation ways for immunostimulant (author's transl)].
The of efficiency of spraying as compared to intranasal and digestive ways was tested on Balb/c mouse by using on the one hand an immunostimulant product and on the other various types of test : Myxovirus influenzae by aerosol, Streptococcus pyogenes intranasally, Klebsiella pneumoniae intraperitoneally. Results showed that in the case of influenza virus the immunostimulant inhaled as liquid aerosol or powder aerosol, or deposited on the nasal mucosa was very active. When the test germ was Streptococcus and the contamination intra-nasal, only the homologous way was efficient. When the test germ was Klebsiella pneumonia all inoculation forms except powder aerosol were effective. The comparative study of aerosols granulometry helps grasping this phenomenon.
D000336:Aerosols; D000818:Animals; D005260:Female; D007114:Immunization / Q000379:methods*; D009980:Influenza A virus / Q000276:immunology*; D007711:Klebsiella pneumoniae / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D013297:Streptococcus pyogenes / Q000276:immunology*
D000336:Aerosols
Etude, chez la souris Balb/c, de l'efficacité de la voie aérosol comparativement à d'autres voies d'inoculation, dans le cas d'un immunostimulant.