Inhibition of prostaglandin biosynthesis by c-5,c-8,c-11-eicosatrienoic acid.
The enzyme prostaglandin H leads to E-isomerase (EC 5.3.99.3), which is present in sheep vesicular gland and needs glutathione as cofactor, is inhibited by c-5,c-8,c-11-eicosatrienoic acid, the fatty acid accumulating during essential fatty acid deficiency. The EFA-deficiency syndrome can partly be explained from a prostaglandin deficiency caused by lack of precursors. The present finding indicates that 5,8,11-eicosatrienoic acid could well be an additional factor in modifying the symptoms of EFA-deficiency.
D000468:Alkalies / Q000494:pharmacology; D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism / Q000494:pharmacology*; D016861:Cyclooxygenase Inhibitors; D005228:Fatty Acids, Essential / Q000172:deficiency; D005978:Glutathione / Q000494:pharmacology; D007535:Isomerases / Q000037:antagonists & inhibitors*; D008297:Male; D008861:Microsomes / Q000201:enzymology / Q000378:metabolism; D011449:Prostaglandin Endoperoxides / Q000096:biosynthesis*; D011458:Prostaglandins E / Q000096:biosynthesis*; D011463:Prostaglandins H / Q000096:biosynthesis*; D012756:Sheep
D000468:Alkalies; D001095:Arachidonic Acids; D016861:Cyclooxygenase Inhibitors; D005228:Fatty Acids, Essential; D011449:Prostaglandin Endoperoxides; D011458:Prostaglandins E; D011463:Prostaglandins H; D007535:Isomerases; D005978:Glutathione