title: Heterologous growth of human ovarian cancer. A new in vivo testing system.
abstract: Successful heterotransplantation of ovarian cancer in the mouse mutant, nude is described, with serial transmission, in one case to date. Light and electron microscopic examination of this tumour, a poorly differentiated adenocarcinoma, has not revealed any alteration in its morphology after six passages. Tumour-bearing mice have been treated with ThioTEPA or 5-Fluoro-Uracil, in an attempt to see if they show a similar effect to that seen in the patient. ThioTEPA resulted in a marked regression, whilst there was no effect from 5-Fluoro-Uracil, on tumour growth--confirming the ThioTEPA effect seen in the patient.
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000648:ultrastructure; D000818:Animals; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007273:Injections, Intramuscular; D007274:Injections, Intraperitoneal; D051379:Mice; D008819:Mice, Nude; D008854:Microscopy, Electron; D008875:Middle Aged; D009368:Neoplasm Transplantation; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000648:ultrastructure; D013852:Thiotepa / Q000008:administration & dosage / Q000627:therapeutic use*; D014183:Transplantation, Heterologous
chemical_list: D013852:Thiotepa; D005472:Fluorouracil