A pathogenic hypothesis of malformation caused by amniocentesis.
The role of amniocentesis in producing fetal malformations has been investigated in the rat. Relevant uterine contractions were observed after amniocentesis. The pathogenetic mechanism of fetal malformations is discussed on the basis of the present results.
D000649:Amniocentesis / Q000009:adverse effects*; D000650:Amnion / Q000502:physiology*; D000818:Animals; D000013:Congenital Abnormalities / Q000209:etiology*; D005260:Female; D006874:Hydrostatic Pressure; D011247:Pregnancy; D051381:Rats; D014599:Uterus / Q000502:physiology