Immunochemical and ultrastructural investigations in a patient with cold-agglutinine-active monoclonal IgMK-gammopathy.
A patient with "chronic cold-agglutinin disease" is described. Initially, the process was a benign monoclonal gammopathy. After an intervall of 6 years clinical, cytomorphological and immunochemical studies showed progress towards malignancy. In the bone marrow intranuclear lipid-like inclusions appeared in the plasma cells.
D000373:Agglutinins; D001323:Autoantibodies; D001853:Bone Marrow / Q000648:ultrastructure; D003080:Cold Temperature; D006801:Humans; D006942:Hypergammaglobulinemia / Q000473:pathology; D007075:Immunoglobulin M; D007145:Immunoglobulin kappa-Chains; D008297:Male; D008854:Microscopy, Electron; D010265:Paraproteinemias / Q000473:pathology*; D010950:Plasma Cells
D000373:Agglutinins; D001323:Autoantibodies; D007075:Immunoglobulin M; D007145:Immunoglobulin kappa-Chains