Mutagenicity of the halogenated olefin, 2-bromo-2-chloro-1,1-difluoroethylene, a presumed metabolite of the inhalation anesthetic halothane.
The presumed halothane metabolite, 2-bromo-1,1-difluoroethylene, produces both base substitution and frameshift mutations in Salmonella typhimurium. Direct mutagenesis of isolated DNA also was observed by using a Bacillus subtils transformation assay to score the production of mutagenic lesions in transforming DNA.
D001412:Bacillus subtilis / Q000187:drug effects / Q000235:genetics; D004269:DNA, Bacterial / Q000235:genetics; D005030:Ethylenes / Q000633:toxicity*; D006221:Halothane / Q000378:metabolism*; D006846:Hydrocarbons, Halogenated / Q000633:toxicity*; D009154:Mutation / Q000187:drug effects*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics
D004269:DNA, Bacterial; D005030:Ethylenes; D006846:Hydrocarbons, Halogenated; D006221:Halothane