[Experiments on the mechanism of action of vascular spasmolytics. 4. Effect of nitroprusside sodium, nitroglycerin, prenylamine and verapamil on the calcium uptake of microsomes of the smooth bascular muscles].
Nitroprusside-sodium, nitroglycerol, and verapamil had no effect on the calcium uptake by microsomes from the carotid artery of cattle. Prenylamine reduced the passive binding and the active uptake and released already bound calcium. The basal Mg-dependendent ATPase and Ca-stimulatable Mg-ATPase were inhibited by prenylamine.
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002339:Carotid Arteries / Q000378:metabolism*; D002417:Cattle; D008861:Microsomes / Q000378:metabolism*; D009125:Muscle Relaxants, Central / Q000494:pharmacology*; D009130:Muscle, Smooth / Q000187:drug effects* / Q000378:metabolism; D005996:Nitroglycerin / Q000494:pharmacology; D009599:Nitroprusside / Q000494:pharmacology; D011299:Prenylamine / Q000494:pharmacology; D014700:Verapamil / Q000494:pharmacology
D009125:Muscle Relaxants, Central; D009599:Nitroprusside; D014700:Verapamil; D005996:Nitroglycerin; D011299:Prenylamine; D002118:Calcium
Versuche zum Wirkungsmechanismus von Gefässspasmolytika. 4. Wirkung von Nitrosprussid-Natrium, Nitroglyzerin, Prenylamin und Verapamil auf die Ca-Aufnahme von Mikrosomen aus glatter Gefässmuskulatur.