title: Depression treated with imipramine and ECT: the DeCarolis study reconsidered.
abstract: The authors reevaluate a large prospective Italian study (437 patients) that compared high-dose imipramine with ECT treatment in the treatment of depression. The superiority of ECT was evident among patients with endogenous depression, and especially evident among those with delusional depression (83% improved with ECT versus 40% with imipramine) and depressions defined as severe (83% versus 35%).
mesh_terms: D000275:Adjustment Disorders / Q000628:therapy; D000341:Affective Disorders, Psychotic / Q000628:therapy; D001714:Bipolar Disorder / Q000628:therapy; D003702:Delusions / Q000628:therapy; D003863:Depression / Q000628:therapy*; D004305:Dose-Response Relationship, Drug; D004565:Electroconvulsive Therapy; D005260:Female; D006801:Humans; D007099:Imipramine / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D019965:Neurocognitive Disorders / Q000628:therapy; D012559:Schizophrenia / Q000628:therapy
chemical_list: D007099:Imipramine