Cyanide-insensitive respiration in Schizophyllum commune.
Two mutants of the hymenomycete Schizophyllum commune, unable to use acetate as the sole carbon source for growth, were isolated. Growth of the mutants on a glucose minimal medium was only slightly inhibited by sodium azide. Genetic analysis revealed mutations in different chromosomal genes in the respective mutants. Both these mutants exhibited a high cyanide-insensitive endogenous respiration. The inhibition of the respiration by 8-hydroxyquinoline showed the mutants to respire predominantly by an alternative respiratory pathway observed in many fungal species, but not in the hymenomycetes so far. An enhanced cyanide-insensitive respiration was also found in a wild-type strain of Schizophyllum commune grown in the presence of sodium azide.
D000085:Acetates / Q000378:metabolism; D000363:Agaricales / Q000378:metabolism*; D001386:Azides / Q000494:pharmacology; D003486:Cyanides / Q000494:pharmacology*; D005808:Genes, Recessive; D005947:Glucose / Q000378:metabolism; D009154:Mutation; D010101:Oxygen Consumption / Q000187:drug effects*; D015125:Oxyquinoline / Q000494:pharmacology; D012567:Schizophyllum / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*
D000085:Acetates; D001386:Azides; D003486:Cyanides; D015125:Oxyquinoline; D005947:Glucose