Massive lymphadenopathy mimicking lymphoma in leukemic reticuloendotheliosis.
Leukemic reticuloendotheliosis is increasingly noted to have a spectrum of laboratory findings suggestive of both lymphocytes and monocytes. However, previous reports have not noted a clinical presentation which may be confused with lymphoma. This report documents a case of leukemic reticuloendotheliosis in a 29 year old man with clinical findings of diffuse lymphadenopathy, organomegaly and cutaneous involvement. As cytotoxic agents may be dysfunctional in leukemic reticuloendotheliosis, the ability to distinguish between the disorder and a lymphomatous process may be critical to the patient's management. Both morphologic examination of the "hairy-cell" and cytochemistry may not give an unequivocal differentiation between these two diseases. However, functional studies of the neoplastic cell, such as cell-marker analysis, phagocytic function and ultrastructural morphology, can define by noninvasive methods the correct diagnosis in the atypical presentation of leukemic reticuloendotheliosis.
D000328:Adult; D003937:Diagnosis, Differential; D006801:Humans; D007943:Leukemia, Hairy Cell / Q000175:diagnosis* / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D008223:Lymphoma / Q000175:diagnosis*; D008297:Male; D011947:Receptors, Antigen, B-Cell / Q000032:analysis; D012397:Rosette Formation
D011947:Receptors, Antigen, B-Cell