[Dynamics of components of the kallikrein-kinin system in the arterial and venous blood and cerebrospinal fluid of patients with severe cranio-cerebral injuries].
Comparative study of the activity dynamics of the components of the kallikrein-kinin system in portions of blood flowing to the brain and draining from it and in the cerebrospinal fluid was carried out in 26 patients with a severe craniocerebral trauma. It was found that activation of the system is displayed by a considerable increase in spontaneous esterase activity, a fall in the activity of kallikrein inhibitors, and a decrease in the content of prekallikrein and kininogen. The degree of activation depends on the severity of the lesion, reaches the maximum level by the 3rd--4th day of the development of the pathological process, and is manifested most fully in blood draining from the brain.
D000328:Adult; D001158:Arteries; D001930:Brain Injuries / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D004950:Esterases / Q000032:analysis*; D006801:Humans; D007610:Kallikreins / Q000032:analysis* / Q000037:antagonists & inhibitors*; D007704:Kininogens / Q000032:analysis*; D008875:Middle Aged; D011288:Prekallikrein / Q000032:analysis*; D012886:Skull / Q000293:injuries*; D014680:Veins
D007704:Kininogens; D011288:Prekallikrein; D004950:Esterases; D007610:Kallikreins
Dinamika komponentov kallikrein-kininovoĭ sistemy v arterial'noi, venoznoĭ krovi i likvore u bol'nykh s tiazheloĭ cherepno-mozgovoĭ travmoĭ.