Histocompatibility antigens and genetic control of the immune response in guinea-pigs. V. Evidence from further breeding studies for the polygenic control of the cellular immune response to structurally unrelated antigens in the guinea-pig.
Further breeding studies were carried out to investigate the polygenic control of the cellular immune response in the guinea-pig to low doses of aspirin anhydride (ASAN), penicilloylated bovine immunoglobulin (BPO-BGG) and to the multi-chain copolymer (T, G)-A-L. Although responsiveness to these three antigens is controlled by three independently segregating loci, at least one gene required for these responses is linked to the strain 13 haplotype.
D000818:Animals; D000941:Antigens; D001241:Aspirin / Q000276:immunology; D001947:Breeding; D002417:Cattle; D004306:Dose-Response Relationship, Immunologic; D005802:Genes, MHC Class II; D006168:Guinea Pigs / Q000235:genetics; D006649:Histocompatibility Antigens; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007111:Immunity, Cellular; D007074:Immunoglobulin G; D010455:Peptides / Q000276:immunology
D000941:Antigens; D006649:Histocompatibility Antigens; D007074:Immunoglobulin G; D010455:Peptides; D001241:Aspirin