The significance of a low amniotic fluid creatinine and a mature lecithin/sphingomyelin ratio.
Creatinine levels were measured in 546 specimens of amniotic fluid with a lecithin/sphingomyelin ratio of 2.5 or more. With amniotic fluid creatinine levels below the normal range, 3 of 6 infants had major congenital abnormalities and two had severe rhesus isoimmunization; 3 of the infants died. Of 514 cases with amniotic fluid creatinine levels within the normal range (mean +/- 2 SD), 13 babies (2.5%) had major congenital abnormalities but only one of the babies died, giving a perinatal mortality rate of 0.2%. The significance of these findings is discussed.
D000653:Amniotic Fluid / Q000032:analysis*; D001787:Blood Group Incompatibility / Q000175:diagnosis; D000013:Congenital Abnormalities / Q000175:diagnosis; D003404:Creatinine / Q000032:analysis*; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis*; D006801:Humans; D010713:Phosphatidylcholines / Q000032:analysis*; D011247:Pregnancy; D012204:Rh-Hr Blood-Group System; D013109:Sphingomyelins / Q000032:analysis*
D010713:Phosphatidylcholines; D012204:Rh-Hr Blood-Group System; D013109:Sphingomyelins; D003404:Creatinine