In vitro effects of melanocytolytic agents and other compounds upon dominant human melanoma tyrosinase activity.
The activity of dominant human melanoma tyrosinase isozyme was greatly decreased by certain reducing agents. The number and geometry of phenolic groups as well as free--SH group appear important for enzymic inhibition.
D004156:Catechol Oxidase / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D007527:Isoenzymes / Q000378:metabolism; D008545:Melanoma / Q000201:enzymology*; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D010636:Phenols / Q000494:pharmacology; D013438:Sulfhydryl Compounds / Q000494:pharmacology
D007527:Isoenzymes; D010636:Phenols; D013438:Sulfhydryl Compounds; D004156:Catechol Oxidase; D014442:Monophenol Monooxygenase