Chemotherapeutic effects of 4-isothiocyanato-4'-nitrodiphenylamine (C9333-Go/CGP 4540) on infections with Nematospiroides dubius, Hymenolepis diminuta, Hymenolepis nana and Spirometra mansonoides.
4-Isothiocyanato-4'-nitrodiphenylamine possessed anthelmintic activity against Nippostrongylus dubius and Hymenolepis nana in mice and H. diminuta in rats as determined by both egg counts and recovery of parasites at autopsy. No activity was detected against the cestode. Spirometra mansonoides, in cats.
D000814:Aniline Compounds / Q000627:therapeutic use*; D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D002415:Cats; D002590:Cestode Infections / Q000188:drug therapy*; D004159:Diphenylamine / Q000031:analogs & derivatives / Q000627:therapeutic use*; D006926:Hymenolepis; D017879:Isothiocyanates; D051379:Mice; D009349:Nematode Infections / Q000188:drug therapy*; D010270:Parasite Egg Count; D051381:Rats; D013146:Spirometra; D013861:Thiocyanates / Q000627:therapeutic use*
D000814:Aniline Compounds; D000871:Anthelmintics; D017879:Isothiocyanates; D013861:Thiocyanates; D004159:Diphenylamine; C012391:amoscanate