Tetrapyrrole biosynthesis from 4,5-dioxovaleric acid in rhodopseudomonas spheroides.
Prophyrin biosynthesis from 4,5-dioxovaleric acid was studied in cell suspensions of R. spheroides. The experiments show that 4,5-dioxovaleric acid is a far precursor of porphyrins through delta amino laevulinic acid formation in a transmination reaction involving also l-alanine. It differs radically from the classical delta aminolaevulinic acid synthesis using glycine and succinyl CoA as substrates.
D000409:Alanine / Q000378:metabolism; D000622:Aminolevulinic Acid / Q000378:metabolism; D011166:Porphyrins / Q000096:biosynthesis*; D012241:Rhodopseudomonas / Q000378:metabolism*; D014631:Valerates / Q000378:metabolism
D011166:Porphyrins; D014631:Valerates; D000622:Aminolevulinic Acid; D000409:Alanine