[Effect of non-antibiotic stimulators on laboratory rats].
The stimulative effect of Carbadox, Nitrovin and Glypondin substances was tested on juvenile rats. A stimulative effect relative to physical weight was proved only with Carbadox at a dose of 2 mg kg-1 and Nitrovin (only in males) in doses of 10 and 50 mg kg-1 p. o. An overdosing of Carbadox revealed rather a negative effect, because already a dose ten times higher had a negative effect on physical growth and a dose fifty times higher caused obvious toxical symptoms. Glypondin was ineffective in each of the tested doses. The consumption of food per unit of weight increase was reduced after supplying carbadox dosed at 2 mg kg-1 by 25.6% in males and by 10.8% in females. After Nitrovin the intake of food was reduced most after a dose of 10 mg kg-1 in both sexes (8.6 and 8.4% respectively). The most frequent effect on the change of physical weight was the relative reduction in weight of the thyroid gland. For the screening of stimulators laboratory rats are not very suitable.
D000818:Animals; D001823:Body Composition / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects*; D002218:Carbadox / Q000494:pharmacology; D005260:Female; D006133:Growth Substances / Q000494:pharmacology; D008297:Male; D009610:Nitrovin / Q000494:pharmacology; D051381:Rats; D013268:Stimulation, Chemical
D006133:Growth Substances; D009610:Nitrovin; D002218:Carbadox
Působení neantibiotických stimulátrů na laboratorní krysy.