Ceruletide-assisted cholecystography: a clinical assessment.
The cholecystokinetic effect of ceruletide, a synthetic decapeptide similar in action to cholecystokinin, was examined in both a randomized and nonrandomized study in 81 patients scheduled for routine oral cholecystograms. Intramuscular injection of ceruletide in a dose of 0.3 microgram/kg resulted in a mean maximum contraction of the gallbladder of 68% and a mean time until maximum contraction of 28 minutes. Visualization of the cystic duct occurred in 57 patients (70%); the common duct was seen in 67 (83%). Ceruletide demonstrated superior gallbladder contraction when compared to fatty meals and demonstrated no interference with a subsequent upper gastrointestinal series.
D000328:Adult; D000368:Aged; D002108:Ceruletide / Q000008:administration & dosage / Q000494:pharmacology; D002765:Cholecystography / Q000379:methods*; D003135:Common Bile Duct / Q000000981:diagnostic imaging; D003549:Cystic Duct / Q000000981:diagnostic imaging; D005260:Female; D005704:Gallbladder / Q000187:drug effects / Q000503:physiopathology; D005705:Gallbladder Diseases / Q000000981:diagnostic imaging; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects
D002108:Ceruletide