Phosphonate analogue of 2'-deoxy-5-fluorouridylic acid.
The phosphonate analogue (6) of 2'-deoxy-5-fluorouridylic acid has been prepared via a Pfitzner--Moffatt oxidation and Witting reaction. This compound was found to inhibit thymidylate synthetase from three sources and to be cytotoxic to H.Ep.-2 cells in culture.
D000970:Antineoplastic Agents / Q000138:chemical synthesis; D003856:Deoxyuracil Nucleotides / Q000138:chemical synthesis*; D005468:Fluorodeoxyuridylate / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D013940:Thymidylate Synthase / Q000037:antagonists & inhibitors
D000970:Antineoplastic Agents; D003856:Deoxyuracil Nucleotides; D005468:Fluorodeoxyuridylate; D013940:Thymidylate Synthase