title: [Pathophysiology of kidney lesions after temporary ischemia and measures for their prevention].
abstract: The efficacy of the so-called "hyperosmolar kidney preservation" is pointed out with respect to protecting the kidney from the otherwise lethal effect of protracted periods of normothermic ischemia. Furthermore the protective effect of various pharmacologic agents against 2 and 3 hours of normothermic ischemia is investigated and the morphology and pathophysiology of renal ischemic damage is pointed out. In further experiments extracorporeal renal operations were performed in 12 dogs to determine the efficacy of a new renal preservation method.
mesh_terms: D000818:Animals; D002746:Chlorpromazine / Q000494:pharmacology; D003404:Creatinine / Q000097:blood; D004285:Dogs; D004487:Edema / Q000209:etiology; D004573:Electrolytes; D005665:Furosemide / Q000494:pharmacology; D006493:Heparin / Q000494:pharmacology; D007035:Hypothermia; D007511:Ischemia / Q000150:complications*; D007668:Kidney / Q000473:pathology*; D007684:Kidney Tubules / Q000503:physiopathology*; D008353:Mannitol / Q000494:pharmacology; D009926:Organ Preservation; D009994:Osmolar Concentration; D010477:Perfusion; D011817:Rabbits
chemical_list: D004573:Electrolytes; D008353:Mannitol; D005665:Furosemide; D006493:Heparin; D003404:Creatinine; D002746:Chlorpromazine
vernacular_title: Pathophysiologie der Nierenschädigung nach temporärer Ischämie und Massnahmen zu deren Verhinderung.