The modulatory effect of exogenously added prostaglandin E1 or E2 on the delayed-type hypersensitivity reaction of normal or tumored mice.
The effect of exogenously added prostaglandin (PG) E1 or E2 over concentration ranges of from 1 x 10(-4) to 1 x 10(-9)M were studied in order to determine their effect on the delayed-type hypersensitivity (DtH) reaction of normal or tumored mice. PGE1 or PGE2 generally caused a stimulation over the control values of normal mice as detected by the footpad swelling assay. However, PGE1 or PGE2 at all concentrations tested were found to significantly inhibit the DtH reaction of CD2F1 tumored mice.
D000527:Alprostadil / Q000494:pharmacology*; D000818:Animals; D015232:Dinoprostone / Q000494:pharmacology*; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000276:immunology*
D000527:Alprostadil; D015232:Dinoprostone