Islet of Langerhans allotransplantation in the rat.
Normoglycemia in rats allotransplanted with islets of Langerhans was studied. It was found that pretreatment with donor liver extract and pertussis followed by a short course of ALS treatment results in much better overall survival of functioning islets of Langerhans allotransplants than with other forms of immunosuppression tested.
D000818:Animals; D000961:Antilymphocyte Serum / Q000494:pharmacology; D001786:Blood Glucose / Q000032:analysis; D006085:Graft Survival; D007166:Immunosuppressive Agents; D016381:Islets of Langerhans Transplantation; D008297:Male; D011239:Prednisolone / Q000494:pharmacology; D051381:Rats; D011917:Rats, Inbred Lew; D011920:Rats, Inbred WF; D014184:Transplantation, Homologous; D014185:Transplantation, Isogeneic
D000961:Antilymphocyte Serum; D001786:Blood Glucose; D007166:Immunosuppressive Agents; D011239:Prednisolone