title: [5-hydroxytryptamine-sensitive adenylate cyclase activity in brain synaptosomal membrane preparations].
abstract: A serotonine-sensitive adenylate cyclase system has been observed in horse brain membrane preparations. In crude mitochondrial fraction two types of activation sites were characterized, the Ka being = 2 nM and 1 micrometer. In purified synaptosomal membranes, a single adenylate cyclase activation was observed corresponding to the highest apparent affinity (KD = 2nM). This activation site might be related to the high affinity binding site (KD = 2NM) were previously described in the same membrane preparations.
mesh_terms: D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology*; D004789:Enzyme Activation / Q000187:drug effects; D006736:Horses; D007700:Kinetics; D008566:Membranes / Q000201:enzymology; D012701:Serotonin / Q000494:pharmacology*; D013574:Synaptosomes / Q000201:enzymology*
chemical_list: D012701:Serotonin; D000262:Adenylyl Cyclases
vernacular_title: Activation adénylcyclasique sensible à la 5-hydroxytryptamine sur des préparations membranaires synaptosomales de cerveau.