[Inhibition of DNA biosynthesis in human lymphocytes by alpha 1-antitrypsin].
Incorporation of tritiated thymidine into human lymphocytes from tonsils is markedly inhibited by purified alpha1-antitrypsin-preparations. This inhibitory effect is observed in lymphocytes stimulated by a mitogen factor (phytohemagglutinin) as in non stimulated lymphocytes.
D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis*; D006801:Humans; D037102:Lectins; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism*; D013936:Thymidine / Q000378:metabolism; D000515:alpha 1-Antitrypsin / Q000378:metabolism / Q000494:pharmacology*
D037102:Lectins; D000515:alpha 1-Antitrypsin; D004247:DNA; D013936:Thymidine
Inhibition de la biosynthèse du DNA chez les lymphocytes humains par l'effet de l'alpha1-antitrypsine.