Studies on the enhancement of rat islet allografts.
Attempts to improve the induction of immunological enhancement of (AS X August)F1 pancreatic islet allografts in diabetic AS rats have been carried out. First, by treating the diabetic AS recipient with enhancing serum obtained from AS rats with functioning enhanced (AS X August)F1 islet allografts. In these rats on 1 of 5 islet allografts had a prolonged survival, the other 4 being rejected by 2 days. Second, by transplanting (AS X August)F1 islet allografts into diabetic AS rats bearing functioning enhanced (AS X August)F1 cardiac allografts. All of these islet allografts were rejected by 2 days.
D000818:Animals; D005260:Female; D006085:Graft Survival; D016027:Heart Transplantation; D007106:Immune Sera; D007165:Immunosuppression Therapy / Q000379:methods*; D016381:Islets of Langerhans Transplantation; D007518:Isoantibodies; D008297:Male; D051381:Rats; D014184:Transplantation, Homologous
D007106:Immune Sera; D007518:Isoantibodies