[Investigations on the antimicrobial activity of amin-aldehyde-condensates. 2. Communication: unsymmetrically substituted animals of formaldehyde (author's transl)].
In the scope of our research about the antimicrobial activity of aldehyde-amin-condensates a number of partly new unsymmetrically substituted animals was synthesized by reaction of formaldehyde with different secondary amines. Structures and physically constants are shown in the tables 1 and 2. The antimicrobial activity is demonstrated by the results of the disktest (table 3), of the minimal inhibition concentration (MIC, table 4) and the suspension and area disinfecting tests following the method of the DGHM (tables 5 and 6). For this testing a standardized formulation was used to eliminate the different solubility effects of the various animals. This formulation does not influence the test results. It may be shown, that unsymmetrically substituted animals have both germistatic activity mainly versus Staphylococcus aureus and Bacillus subtilis and germicidal activity especially versus Pseudomonas aeruginosa, Proteus vulgaris, Trichophyton mentagrophytes and Micosporum gypseum.
D001412:Bacillus subtilis / Q000187:drug effects; D001419:Bacteria / Q000187:drug effects*; D005557:Formaldehyde / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D008864:Microsporum / Q000187:drug effects; D011514:Proteus vulgaris / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D014249:Trichophyton / Q000187:drug effects
D005557:Formaldehyde
Untersuchungen zur antimikrobiellen Wirksamkeit von Amin-Aldehydkondensaten. 2. Mitteilung: Unsymmetrisch substituierte Formaldehydaminale.