Synergistic action of vincristine and adriamycin in the treatment of experimental rat leukemia L5222.
The therapeutic effect of different ratios of a combination of vincristine and Adriamycin was compared to monotherapy with both substances in advanced rat leukemia L5222. The combination therapy proved to by synergistic. In the upper dose range, no additive toxicity was observed. The combination of 25% vincristine plus 75% Adriamycin effected the best results. In a clinically relevant dose range, the superiority of this ratio was observed independent of the application sequence of the two substances and independent of the time interval between the applications within an 11-hr investigation period.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000008:administration & dosage*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D007942:Leukemia, Experimental / Q000188:drug therapy*; D051381:Rats; D014750:Vincristine / Q000008:administration & dosage*
D014750:Vincristine; D004317:Doxorubicin