[Role of vacuolar apparatus overload in lysosomal changes in liver cells in acute toxic hepatitis].
Physical and chemical properties of the rat liver lysosomes with single Triton WR 1339 overloading were studied during the administration of a detergent to intact rats and those with acute toxic hepatitis. Administration of the latter to intact animals was accompanied by a reduction of the floating density of the particles, solubilization of the lysosome enzymes and by increased fragility of the particles in the hypotonic medium. Lysosomes of the hepatocytes in rats with toxic hepatitis also displayed signs of overloading of the vacuolar apparatus with the preparation administered. The most pronounced solubilization of the lysosomal enzymes beta-galactosidase, acid RNA-ase, cathepsin D--was noted in case of combined action of CCl4 and Triton WR 1339 24, 48, 72 hours and 7 days after the CCl4 poisoning. Possible consequences of overloading of the vacuolar apparatus of the rat hepatocytes are discussed.
D000208:Acute Disease; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000503:physiopathology; D056486:Chemical and Drug Induced Liver Injury / Q000503:physiopathology*; D004789:Enzyme Activation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000648:ultrastructure*; D008247:Lysosomes / Q000187:drug effects*; D008297:Male; D009940:Organoids / Q000187:drug effects*; D009996:Osmotic Fragility / Q000187:drug effects; D011092:Polyethylene Glycols / Q000494:pharmacology; D051381:Rats; D012995:Solubility; D013997:Time Factors; D014617:Vacuoles / Q000187:drug effects*
D011092:Polyethylene Glycols
Rol' peregruzki vakuoliarnogo apparata v izmeneniiakh lizosom kletok pecheni pri ostrom toksicheskom gepatite.