title: Lumbo-sacral radiculography with a new, water-soluble contrast medium: myelografin (meglumine ioserinate, SSH 239 AB).
abstract: The authors present the results of a clinical trial of a new water-soluble contrast medium for radiculography: meglumine ioserinate. This trial was conducted on eighty eight patients in the Orthopaedic Clinic of the University of Rome between 1975 and 1976. The patients were subdivided into two groups, one of fifty four in whom a single dose of 5 ml was injected, the other of thirty four who received a double dose of 10 ml of contrast medium. In the latter the medium was always injected undiluted. No disturbances following radiculography were reported by 58 per cent of the first group and 44 per cent of the second. The clinical side-effects encountered in the other patients are analysed. These side-effects were negligible in the majority of cases, and occurred less frequently than with meglumine iothalamate, and at least more often than with meglumine iocarmate. Finally, the findings in the cerebrospinal fluid are described, before and twenty four hours after the test, in a small group of these patients. The contrast and diffusibility were found to be excellent, as also was the tolerance, which has the advantage that the patient can be kept in the horizontal position after the examination. Despite this, because of some changes encountered in the cerebrospinal fluid, and because of a convulsive episode presented by one patient treated with the double dose, the authors advise diluting the contrast medium in distilled water, so as to lower the osmotic pressure.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D003287:Contrast Media / Q000009:adverse effects; D005260:Female; D006261:Headache / Q000139:chemically induced; D006801:Humans; D007463:Iodobenzoates; D008159:Lumbar Vertebrae / Q000294:innervation*; D008297:Male; D008536:Meglumine / Q000009:adverse effects; D008875:Middle Aged; D009192:Myelography / Q000379:methods*; D009207:Myoclonus / Q000139:chemically induced; D009437:Neuralgia / Q000139:chemically induced; D010292:Paresthesia / Q000139:chemically induced; D012447:Sacrum / Q000294:innervation*; D012995:Solubility; D013126:Spinal Nerve Roots / Q000000981:diagnostic imaging*; D014283:Triiodobenzoic Acids
chemical_list: D003287:Contrast Media; D007463:Iodobenzoates; D014283:Triiodobenzoic Acids; C013105:meglumine ioserinate; D008536:Meglumine