Clinical pharmacological studies of tandamine, a potential antidepressive drug.
Tandamine hydrochloride, a thiopyranoindole, was more active than desmethylimipramine in inhibiting the tyramine pressor response after single oral doses in human volunteers. When compared with a placebo, tandamine was found to possess significant anticholinergic activity, to reduce appetite and to produce sedation. Compared with clomipramine, it caused a smaller inhibition of 5-HT but a more marked inhibition of dopamine uptake into human platelets. Further clinical and pharmacological studies with tandamine may help to elucidate the respective roles of different monoamines in depression, sedation and appetite.
D000328:Adult; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D001066:Appetite / Q000187:drug effects; D001143:Arousal / Q000187:drug effects; D001792:Blood Platelets / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D002997:Clomipramine / Q000494:pharmacology; D003891:Desipramine / Q000494:pharmacology; D004298:Dopamine / Q000097:blood; D005260:Female; D006801:Humans; D007211:Indoles / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D010275:Parasympathetic Nervous System / Q000187:drug effects; D011680:Pupil / Q000187:drug effects; D012463:Saliva / Q000378:metabolism; D012701:Serotonin / Q000097:blood; D014439:Tyramine / Q000037:antagonists & inhibitors
D000929:Antidepressive Agents, Tricyclic; D007211:Indoles; D012701:Serotonin; D002997:Clomipramine; D003891:Desipramine; D004298:Dopamine; D014439:Tyramine