title: [Acute primary plasma cell leukemia (author's transl)].
abstract: The sudden onset of plasma cell leukemia with IgG-lambda-paraproteinaemia is reported in a 59-year-old patient. In the year before clinical manifestation of the disease the patient was examined and treated for a duodenal ulcer and a head injury on three separate occasions in different wards of the hospital without detection of any sign of disease of the haemopoetic system. The clinical features and course of the disease resembled those of acute leukaemia, the maximum percentage of plasma cells in the peripheral blood being 72 and in the bone marrow 98. Osteolytic bone lesions were not observed and there was no renal insufficiency. Therapy with mephelan-prednisolone and cyclophosphamide-prednisolone was not successful in influencing the fatal outcome of the disease.
mesh_terms: D000208:Acute Disease; D003520:Cyclophosphamide / Q000627:therapeutic use; D006801:Humans; D007074:Immunoglobulin G; D007146:Immunoglobulin lambda-Chains; D007952:Leukemia, Plasma Cell; D008297:Male; D008875:Middle Aged; D010265:Paraproteinemias / Q000209:etiology*; D011239:Prednisolone / Q000627:therapeutic use
chemical_list: D007074:Immunoglobulin G; D007146:Immunoglobulin lambda-Chains; D003520:Cyclophosphamide; D011239:Prednisolone
vernacular_title: Akutes Auftreten einer primären Plasmazell-Leukämie