Uricosuric properties of diflunisal in man.
1 The uricosuric effect of diflunisal was studied in eleven normal subjects. 2 Urine and serum uric acid levels were measured and used to assess the effect. 3 Diflunisal caused statistically significant decreases in serum uric acid levels and increases in uric acid clearance at 250 and 375 mg twice daily. 4 Diflunisal taken on an empty stomach caused epigastric discomfort in the high dose group which was obviated when the drug was taken with meals. 5 Diflunisal caused no abnormalities in the measured haematological, urological or biochemical parameters.
D000328:Adult; D000700:Analgesics / Q000009:adverse effects / Q000494:pharmacology*; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D010919:Placebos; D012459:Salicylates / Q000009:adverse effects / Q000494:pharmacology*; D013997:Time Factors; D014527:Uric Acid / Q000097:blood; D014528:Uricosuric Agents
D000700:Analgesics; D010919:Placebos; D012459:Salicylates; D014528:Uricosuric Agents; D014527:Uric Acid