title: Quantitative studies on in vitro transformation of hamster chondrocytes.
abstract: Hamster chondrocytes could be transformed in a quantitative assay system which used X-irradiated feeder layer cells. Morphological transformation occurred on addition of, 4NQO, but not in control cultures. Differentiation was classified into 3 types (good, poor and none); normal and transformed colonies contained similar proportions of the 3 types.
mesh_terms: D015112:4-Nitroquinoline-1-oxide / Q000494:pharmacology*; D000818:Animals; D000831:Animals, Newborn; D002356:Cartilage / Q000166:cytology* / Q000187:drug effects / Q000528:radiation effects; D002454:Cell Differentiation / Q000187:drug effects / Q000528:radiation effects; D002471:Cell Transformation, Neoplastic; D006224:Cricetinae; D066298:In Vitro Techniques; D009600:Nitroquinolines / Q000494:pharmacology*; D014965:X-Rays
chemical_list: D009600:Nitroquinolines; D015112:4-Nitroquinoline-1-oxide