Synthesis of substituted 2-aminopyrrole analogs of lidocaine I.
The synthesis, local anesthetic, and antiarrhythmic properties of nine 2-diethylaminoacetamido-3-cyano-4-methyl-5-substituted pyrroles are described. All compounds showed local anesthetic activity by the guinea pig wheal test and antiarrhythmic activity for chloroform-induced ventricular arrhythmias in mice.
D000779:Anesthetics, Local / Q000138:chemical synthesis; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis; D006168:Guinea Pigs; D008012:Lidocaine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D008722:Methods; D051379:Mice; D011758:Pyrroles / Q000138:chemical synthesis / Q000494:pharmacology
D000779:Anesthetics, Local; D000889:Anti-Arrhythmia Agents; D011758:Pyrroles; D008012:Lidocaine