[The influence of humoral immune mechanisms on metastasizing tumors in humans (author's transl)].
Long-continued stimulation of the immune system by chronic infections or tumors leads to dysfunction of the immunoregulation. Different types of antibody, anti-antibody and immunocomplex point to the fact that it is not a matter of the weakening of the patient's immune defense but that these antibodies are important regulating mechanisms for the immune system. While antibodies directed against a tumor have a useful function for the patient with dissemination of metastasizing tumors, the anti-antibodies and antigenotypic antibodies represent a counterregulation which, in the advanced stage of the disease, eliminates the initial control.
D000888:Antibodies, Anti-Idiotypic; D000912:Antibodies, Neoplasm; D000936:Antigen-Antibody Complex; D006801:Humans; D008207:Lymphatic Metastasis / Q000276:immunology; D009362:Neoplasm Metastasis / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology*; D009360:Neoplastic Cells, Circulating
D000888:Antibodies, Anti-Idiotypic; D000912:Antibodies, Neoplasm; D000936:Antigen-Antibody Complex
Einfluss humoraler Immunmechanismen auf die Metastasierung menschlicher Tumoren.