Morquio's disease and the hearing organ.
Histopathologic evidence offered by a case of Morquio's disease and observed in the hearing organ showed widespread collagen damage, possibly initiated by the general hemorrhageous tendency, while the family history bore evidence of a genetic source. The clinical manifestations comprise striking dwarfism, beaking of the lumbar spine, sternal bulging, flaring of the rib cage, falt vertebrae, marked osteoporosis, prominent joints, semi-crouching stance, short nose. Roentgenograms showed retarded ossification.
D002356:Cartilage / Q000473:pathology; D002675:Child, Preschool; D003638:Deafness / Q000150:complications / Q000473:pathology; D005260:Female; D006801:Humans; D007223:Infant; D009085:Mucopolysaccharidosis IV / Q000150:complications / Q000473:pathology*; D013701:Temporal Bone / Q000473:pathology*