Pathogenesis of corneal damage from pseudomonas exotoxin A.
Pseudomonas aeruginosa exotoxin A was injected into rabbit corneas. Death of epithelial, endothelial, and stromal cells resulted, and necrosis of the cornea followed. Control eyes with exotoxin neutralized by specific antitoxin showed minimal damage. A dose-response pattern was evident. Antitoxin neutralization of pseudomonas exotoxin A in corneal ulcers may have possible therapeutic implications.
D000818:Animals; D001427:Bacterial Toxins / Q000008:administration & dosage*; D003315:Cornea / Q000473:pathology / Q000648:ultrastructure; D003320:Corneal Ulcer / Q000209:etiology* / Q000473:pathology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D011550:Pseudomonas aeruginosa; D011817:Rabbits
D001427:Bacterial Toxins