[Preparation and experimental antitumor activity of a new semi-synthetic antibiotic: 14-diethoxyacetoxy daunorubicin (R.P. 33 921)].
14-diethoxyacetoxy daunorubicin (R.P. 33 921) was chosen among a series of new daunorubicin analogues. Its preparation from daunorubicin and its biological activities are described. It displays an antitumoral activity in mice with a better chemotherapeutic index than daunorubicin and doxorubicin.
D000818:Animals; D000903:Antibiotics, Antineoplastic; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis; D003630:Daunorubicin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D004285:Dogs; D004317:Doxorubicin / Q000494:pharmacology; D009153:Mutagens; D009374:Neoplasms, Experimental / Q000188:drug therapy; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis; D011817:Rabbits
D000903:Antibiotics, Antineoplastic; D009153:Mutagens; D012313:RNA; D004317:Doxorubicin; D004247:DNA; D003630:Daunorubicin
Préparation et activité antitumorale expérimentale d'un nouvel antibiotique semi-synthétique : la diéthoxyacétoxy-14 daunorubicine (33 921 R.P,).