Effect of flavoxate on hyperactive detrusor muscle.
The effect of Flavoxate on hyperactive detrusor contraction was studied in 37 patients, including 11 patients in whom the drug was administered intravenously during the urodynamic study. Beside the evaluation of frequency, nocturia and enuresis, the amplitude and the onset of uninhibited detrusor contraction (in correlation to bladder volume) was registered. The results showed subjective improvement in 61.3%. The complaints mentioned above improved in approximately 50%. The urodynamic data showed diminishing of the mean pressure during uninhibited detrusor contraction by almost 50% and the delay of the onset by 80% of bladder capacity. However, average bladder capacity increase was only 19%. It finally became obvious that the effect of Flavoxate was markedly worse in the neurogenic bladder group in comparison to the motoric urge patients.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D005419:Flavonoids / Q000494:pharmacology*; D005422:Flavoxate / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D009135:Muscular Diseases / Q000188:drug therapy; D001743:Urinary Bladder / Q000187:drug effects*; D001750:Urinary Bladder, Neurogenic / Q000188:drug therapy; D014555:Urination Disorders / Q000188:drug therapy; D014563:Urodynamics / Q000187:drug effects
D005419:Flavonoids; D005422:Flavoxate