Chemical modification of neamine.
The aminocyclitol antibiotic neamine has been modified chemically by removing one or two hydroxyl groups from the 2-deoxystreptamine moiety to give 5- and 6- deoxyneamines (5 and 10), as well as 5,6-dideoxyneamine (15). Their antimicrobial activities were determined against several microorganisms, including kanamycin-resistant strains.
D001412:Bacillus subtilis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D007711:Klebsiella pneumoniae / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008722:Methods; D008826:Microbial Sensitivity Tests; D009161:Mycobacterium / Q000187:drug effects; D009355:Neomycin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D009904:Optical Rotation; D013045:Species Specificity; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship
D009355:Neomycin