title: Sodium cyanate-induced ocular lesions in the beagle.
abstract: Ocular lesions secondary to sodium cyanate administration in the beagle are described. Fifteen dogs were given sodium cyanate at doses of 30 to 170 mg/kg/day, 5 days per week. Fourteen developed cataracts which were generally posterior and subcapsular. Five animals developed corneal lesions. Control beagles and cyanate-treated rats and monkeys did not develop lesions. The one drug-treated beagle without ocular lesions received a maximum dose of 30 mg/kg/day of sodium cyanate for 19 months and achieved a mean carbamylatin of 0.39 residue of cyanate per mol of hemoglobin. Animals developing cataracts received a maximum dose of 119+/-23 mg/kg/day for 28+/-10 months and achieved a mean carbamylation of 0.69+/-0.13 residue/mol. Animals developing corneal lesions received a maximum dose of 113+/-22 mg/kg/day for 36+/-7 months and achieved a mean carbamylation of 0.78+/-0.09 residue/mol. Younger animals appeared more susceptible to the cataractogenic effects of the drug than older ones. Lens intracellular sodium was increased by 100% in the cataractous lenses while potassium was significantly decreased in the lenses with the greatest opacity. Extracellular space was increased in the cataractous lenses by 61%. Reduced glutathione levels were decreased by 34% and lactate leakage into the medium was increased by 12%. Rubidium-86 uptake was increased by 26% in the cataractous lenses, probably reflecting an inadequate compensatory response to increased passive fluxes of cations resulting from a structural or enzymatic lesion.
mesh_terms: D000367:Age Factors; D000818:Animals; D002386:Cataract / Q000139:chemically induced* / Q000378:metabolism; D003315:Cornea / Q000187:drug effects*; D003316:Corneal Diseases / Q000139:chemically induced; D003485:Cyanates / Q000009:adverse effects*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005110:Extracellular Space / Q000187:drug effects; D005123:Eye / Q000648:ultrastructure; D005260:Female; D005978:Glutathione / Q000378:metabolism; D000882:Haplorhini; D006801:Humans; D007908:Lens, Crystalline / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051381:Rats; D012413:Rubidium / Q000378:metabolism; D013045:Species Specificity
chemical_list: D003485:Cyanates; D005978:Glutathione; D012413:Rubidium