[Effect of lead microparticles introduced into the respiratory system of the sensitivity of mice to Pasteurella multocida infection via aerosol].
Lead microparticles, resulting from the pyrolysis of organic lead used as an anti-knock agent in gasoline, were introduced into the lungs of Mice, during a short single exposure. When 6 microgram of lead were retained in the lungs (mean value per Mouse), the phagocytic ability of the pulmonary alveolar macrophages harvested 6 and 18 hrs. later, was significantly reduced. It was observed, in the same conditions, that the resistance of Mice to experimental infection by aerosolized Pasteurella multocida, was significantly reduced. When 3 microgram of lead were retained in the lungs, there was no significant difference between control and intoxicated Mice.
D000336:Aerosols; D000818:Animals; D005260:Female; D007854:Lead / Q000008:administration & dosage / Q000633:toxicity*; D008168:Lung; D008264:Macrophages / Q000187:drug effects / Q000502:physiology; D051379:Mice; D010325:Pasteurella / Q000472:pathogenicity*; D010587:Phagocytosis / Q000187:drug effects
D000336:Aerosols; D007854:Lead
Effet du plomb microparticulaire, introduit dans l'appareil respiratoire, sur la sensibilité de la Souris à l'infection par aérosol de Pasteurella multocida.