title: Transferable plasmids mediating multiple-antibiotic resistance in Streptococcus faecalis subsp. liquefaciens.
abstract: In strain HK187 (Streptococcus faecalis subsp. liquefaciens) four plasmids were isolated. The molecular weights, as analyzed in neutral sucrose gradients and by electron microscopy, were found to be about 36 x 10(6), 31 x 10(6), 26 x 10(6), and 4 x 10(6). Plasmid 3, also designated pFK14, with a molecular weight of 26 x 10(6), was found to be responsible for resistance to chloramphenicol and erythromycin and also for high-level resistance to streptomycin and lincomycin. In mixed cultures these four resistances could be transferred with high frequency to a plasmid-free recipient, S. faecalis strain JH2-2.
mesh_terms: D004269:DNA, Bacterial / Q000032:analysis; D004352:Drug Resistance, Microbial; D013293:Enterococcus faecalis / Q000187:drug effects* / Q000648:ultrastructure; D005111:Extrachromosomal Inheritance; D008826:Microbial Sensitivity Tests; D008854:Microscopy, Electron; D008970:Molecular Weight; D010957:Plasmids; D014461:Ultracentrifugation
chemical_list: D004269:DNA, Bacterial