title: Mutagenicity of organic extracts from Canadian drinking water in the Salmonella/mammalian-microsome assay.
abstract: Organic extracts of chlorinated Ontario drinking water samples have been found to induce mutation and lethality in the Salmonella/mammalian-microsome histadine reversion assay. Collections of water were made at water treatment plants in five municipalities in June 1978. To determine the reproducibility of the positive mutagenic effects found, a second sampling at the same plants was performed in September 1978. Preparation of extracts involved passing 200 liter samples through XAD-2 resin columns which were eluted with a mixture of hexane and acetone, and the eluent was evaporated to dryness. For those extracts with sufficient organic matter, dose-related increases in mutagenicity were observed. Extracts of untreated water from a river and a well were weakly mutagenic.
mesh_terms: D004305:Dose-Response Relationship, Drug; D009152:Mutagenicity Tests; D009153:Mutagens; D009864:Ontario; D012486:Salmonella typhimurium / Q000235:genetics; D014873:Water Pollutants / Q000032:analysis*; D014874:Water Pollutants, Chemical / Q000032:analysis*; D014881:Water Supply / Q000032:analysis*
chemical_list: D009153:Mutagens; D014873:Water Pollutants; D014874:Water Pollutants, Chemical