Some biophysical and biochemical properties of poly(phthaloyl L-lysine) microcapsules containing hemolysate.
Measurements of oxygen equilibrium, zeta-potential, resistance to flow, carbonic anhydrase activity, and catalase activity were made on sheep erythrocyte hemolysate-loaded poly(phthaloyl L-lysine) microcapsules (artificial red blood cells) prepared by an interfacial polycondensation technique. The measurements revealed that oxygen dissociation equilibrium, zeta-potential, and carbonic anhydrase activity of the microcapsules are almost the same as those of sheep erythrocytes, while the microcapsules have a higher resistance to flow and a lower catalase activity than the erythrocytes. Possible ways of improving the properties of the microcapsules were suggested.
D000818:Animals; D002214:Capsules; D002256:Carbonic Anhydrases / Q000097:blood; D002374:Catalase / Q000097:blood; D004912:Erythrocytes / Q000201:enzymology / Q000502:physiology*; D007700:Kinetics; D008954:Models, Biological; D010100:Oxygen / Q000097:blood; D010455:Peptides / Q000097:blood; D011107:Polylysine / Q000031:analogs & derivatives; D012756:Sheep; D014783:Viscosity
D002214:Capsules; D010455:Peptides; D011107:Polylysine; D002374:Catalase; D002256:Carbonic Anhydrases; D010100:Oxygen