[Progestagen and contraceptive activity of a 16alpha-methylene derivative of progesterone].
Data of experimental character reflecting the pharmacological activity of 16alpha-methylene derivative of progesterone--melengesterol acetate--are presented. A high progestagenic activity of the preparation was revealed in a series of tests, namely, the appearance of secretory changes in the uterine endometrium of infantile female rabbits and persistence of pregnancy in ovariectomized rabbits. A high contraceptive activity not accompanied by suppression of ovulation was found in administration of the preparation in low doses combined with mestranol.
D000818:Animals; D000831:Animals, Newborn; D002369:Castration; D003276:Contraceptives, Oral; D003278:Contraceptives, Oral, Hormonal; D004717:Endometrium / Q000187:drug effects; D005260:Female; D006065:Gonadotropins, Pituitary / Q000032:analysis; D008552:Melengestrol Acetate / Q000008:administration & dosage / Q000494:pharmacology*; D008656:Mestranol / Q000008:administration & dosage; D010903:Pituitary Gland, Anterior / Q000032:analysis; D011245:Pregnadienes / Q000494:pharmacology*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects; D045167:Progesterone Congeners; D011817:Rabbits; D051381:Rats
D003276:Contraceptives, Oral; D003278:Contraceptives, Oral, Hormonal; D006065:Gonadotropins, Pituitary; D011245:Pregnadienes; D045167:Progesterone Congeners; D008552:Melengestrol Acetate; D008656:Mestranol
Progestagennaia i kontratseptivnaia aktivnost' 16alpha-metilenproizvodnogo progesterona.