title: The histological effects of composite resin materials on the pulps of monkey teeth.
abstract: Pulpal response of three bis glycol methacrylate composite resins, Smile, Simulate and Experimental Composite no. 2 were tested on primary and permanent monkey teeth using zinc oxide eugenol (ZOE) and silicate as controls. All materials were placed in Class V cavity preparations in Rhesus monkey teeth and evaluated at 3 days and 5 and 8 weeks. The materials were randomly placed in anterior and posterior teeth utilizing 75 primary and 75 permanent teeth. Following perfusion the teeth were prepared by routine histological procedures. The 3 day response of the composite resins was moderate, characterized by disruption of the odontoblasts, vacuolization and mild inflammatory response underlying the cavity. At 5 weeks the formation of reparative dentin and a decrease in the inflammatory response was similar for all resins observed. At 8 weeks a slight increase in reparative dentin and continued decrease in inflammation was noted when compared to the 5 weeks responses. At all time intervals ZOE produced the least pulpal response while silicate produced the most severe response.
mesh_terms: D000818:Animals; D003188:Composite Resins / Q000494:pharmacology*; D003737:Dental Cavity Preparation; D003782:Dental Pulp / Q000187:drug effects*; D003804:Dentin / Q000187:drug effects; D003809:Dentin, Secondary; D000882:Haplorhini; D008253:Macaca mulatta; D008689:Methacrylates / Q000494:pharmacology; D009804:Odontoblasts / Q000187:drug effects; D012823:Silicate Cement / Q000494:pharmacology; D015035:Zinc Oxide-Eugenol Cement / Q000494:pharmacology
chemical_list: D003188:Composite Resins; D008689:Methacrylates; D015035:Zinc Oxide-Eugenol Cement; D012823:Silicate Cement