Malabsorption of hydrochlorothiazide following intestinal shunt surgery.
Hydrochlorothiazide 775mg was administered orally to 5 patients who had undergone intestinal shunt operations for obesity 1.5 to 6 years previously. Postoperative weight loss averaged 53.4kg. The concentrations of hydrochlorothiazide in plasma and urine were determined with gas/liquid chromatography. The mean area under the plasma concentration time curve during 9h in 4 of the patients was 889ng/ml.h. Mean total urinary recovery of hydrochlorothiazide amounted to 23.0mg in the 5 patients, which corresponds to approximately half that seen in healthy volunteers. The gastrointestinal hydrochlorothiazide appears to be substantially reduced after intestinal shunt surgery.
D000328:Adult; D001835:Body Weight; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000097:blood / Q000378:metabolism* / Q000652:urine; D007408:Intestinal Absorption; D007422:Intestines / Q000601:surgery*; D007700:Kinetics; D008297:Male; D013997:Time Factors
D006852:Hydrochlorothiazide