Poor response to oral indomethacin therapy for persistent ductus arteriosus in very low birthweight infants.
Administration of oral indomethacin to treat cardiorespiratory failure in 7 low birthweight infants, after failure of conventional therapy, produced an improvement in only 2 infants. These infants had a higher birthweight than the group as a whole. Surgical ligation, rather than oral indomethacin, may be the treatment of choice for persistent ductus arteriosus in very low birthweight infants.
D004374:Ductus Arteriosus, Patent / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D006801:Humans; D006819:Hyaline Membrane Disease / Q000150:complications; D007213:Indomethacin / Q000627:therapeutic use*; D007223:Infant; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature
D007213:Indomethacin