Synthesis and analgetic activity of 1,2,3,4,5,6-hexahydro-1,6-methano-3-benzozocines.
1,2,3,4,5,6-Hexahydro-1,6-methano-3-benzazocine (1) has been synthesized via a four-step sequence from benzo-norbornadiene. This compound and its N-methyl derivative are more active than codeine in the mouse hot-plate antinociceptive assay and will not suppor morphine dependence in Rhesus monkeys.
D000700:Analgesics / Q000138:chemical synthesis*; D000818:Animals; D001392:Azocines / Q000138:chemical synthesis* / Q000494:pharmacology; D000882:Haplorhini; D006801:Humans; D008253:Macaca mulatta; D051379:Mice; D009021:Morphine Dependence / Q000503:physiopathology; D011930:Reaction Time / Q000187:drug effects; D013375:Substance Withdrawal Syndrome / Q000517:prevention & control
D000700:Analgesics; D001392:Azocines