The activity of 7-methylbenz(a)anthracene metabolites in an in vitro-in vivo carcinogenicity test using mouse lung tissue.
7-Methylbenz(a)anthracene (7-MBA) and its 5,6-oxide and trans-5,6- and trans-8,9-dihydrodiol were tested for carcinogenic activity in a system in which mouse lung tissue was incubated in the presence of a test compound for 1 h and then implanted into isologous mice. All four compounds gave small yields of adenomas and in addition the 5,6-oxide gave two carcinomas.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000031:analogs & derivatives / Q000378:metabolism / Q000633:toxicity; D000230:Adenocarcinoma / Q000139:chemically induced; D000236:Adenoma / Q000139:chemically induced; D000818:Animals; D001551:Benz(a)Anthracenes / Q000031:analogs & derivatives; D002273:Carcinogens; D002471:Cell Transformation, Neoplastic; D005260:Female; D066298:In Vitro Techniques; D008175:Lung Neoplasms / Q000139:chemically induced*; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000139:chemically induced; D014185:Transplantation, Isogeneic
D001551:Benz(a)Anthracenes; D002273:Carcinogens; D015127:9,10-Dimethyl-1,2-benzanthracene