Homocitrate synthase as the crucial site of the lysine effect on penicillin biosynthesis.
Homocitrate reverses the lysine inhibition of penicillin bisynthesis. Since lysine is known to inhibit homocitrate synthase, reversal by the reaction product identifies this enzyme as the crucial site of the lysine effect.
D008239:Lysine / Q000494:pharmacology*; D007652:Oxo-Acid-Lyases / Q000378:metabolism*; D010406:Penicillins / Q000096:biosynthesis*; D010407:Penicillium / Q000201:enzymology*; D010408:Penicillium chrysogenum / Q000201:enzymology* / Q000378:metabolism; D013997:Time Factors
D010406:Penicillins; D007652:Oxo-Acid-Lyases; D008239:Lysine