Treatment of gonorrhea with trimethoprim-sulfamethoxazole.
The following regimens were randomly administered to 271 men with gonococcal urethritis: 4.8 X 10(6) units of aqueous procaine penicillin G intramuscularly plus 1 g of probenecid orally (APPG); nine tablets of trimethoprim-sulfamethoxazole (TMP-SMZ; 720 mg of TMP and 3,600 mg of SMZ), orally as a single dose (TMP-SMZ-9); and 12 tablets of TMP-SMZ (960 mg of TMP and 4,800 mg of SMZ) orally as two doses of six tablets taken at a 6-hr interval (TMP-SMZ-12). The failure rates of the APPG, TMP-SMZ-9, and TMP-SMZ-12 regimens were 4%, 23%, and 19%, respectively. APPG was significantly more effective (P less than 0.05) than TMP-SMZ-9 or TMP-SMZ-12. Isolates of Neisseria gonorrhoeae from treatment failures as compared to those from treatment successes were significantly more resistant to SMZ (P less than 0.01) and to the TMP-SMZ combination in a ratio of 19 parts SMZ to one part TMP (P less than 0.05). Minimal inhibitory concentrations of SMZ, TMP, TMP-SMZ, and penicillin G showed positive correlation coefficients.
D000284:Administration, Oral; D002986:Clinical Trials as Topic; D004338:Drug Combinations; D006069:Gonorrhea / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects; D010402:Penicillin G Procaine / Q000627:therapeutic use; D013420:Sulfamethoxazole / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D014295:Trimethoprim / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*
D004338:Drug Combinations; D010402:Penicillin G Procaine; D014295:Trimethoprim; D013420:Sulfamethoxazole