Tumor promotion and the induction of epidermal ornithine decarboxylase activity in mechanically stimulated mouse skin.
Wounding by incision was a promoting stimulus in mouse skin previously initiated with 7,12-dimethylbenz-(a)anthracene. Skin massage elicited a marked proliferative response in skin but was not a promoting stimulus. Wounding mouse skin, either by multiple scalpel incisions or by stripping with silicon carbide paper, led to a marked induction of ornithine decarboxylase activity. In both instances activity was maximal between 20 and 26 hr after wounding, with a secondary rise at 72 hr. Skin massage did not lead to a detectable increase in ornithine decarboxylase activity over the same time period.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D002262:Carboxy-Lyases / Q000096:biosynthesis*; D002455:Cell Division; D005260:Female; D051379:Mice; D009374:Neoplasms, Experimental / Q000209:etiology; D009955:Ornithine Decarboxylase / Q000096:biosynthesis*; D010212:Papilloma / Q000209:etiology*; D010812:Physical Stimulation; D012867:Skin / Q000166:cytology / Q000201:enzymology*; D012878:Skin Neoplasms / Q000209:etiology*
D015127:9,10-Dimethyl-1,2-benzanthracene; D002262:Carboxy-Lyases; D009955:Ornithine Decarboxylase