Malignant transformation of polyostotic fibrous dysplasia.
We have described an unusual case of polyostotic fibrous dysplasia in a 25-year-old white woman who had malignant transformation into a mesenchymal tumor with widespread metastases and features of rhabdomyosarcoma. Masculinization also occurred with high plasma testosterone levels. A mechanism for the development of masculinizing features is discussed.
D000328:Adult; D001859:Bone Neoplasms / Q000209:etiology / Q000473:pathology*; D002471:Cell Transformation, Neoplastic; D005260:Female; D005357:Fibrous Dysplasia of Bone / Q000473:pathology*; D005359:Fibrous Dysplasia, Polyostotic / Q000150:complications / Q000473:pathology*; D006621:Hip Joint; D006801:Humans; D012208:Rhabdomyosarcoma / Q000209:etiology / Q000473:pathology; D014770:Virilism / Q000209:etiology