Ly phenotype and mechanism of action of mouse neonatal suppressor T cells.
Neonatal suppressor T cells were isolated from the thymuses of 10- to 14-day old BDF mice infected at birth with mouse thymic virus. Such cells were enriched for suppressive activity directed against antibody formation by adult B cells and represented a relatively homogenous population of outer cortical cells. Their surface antigen phenotype was found to be: Ly 1+, Ly 2+, TL+, Thy 1+, and H-2+. The cells were larger and contained more DNA than thymocytes from age-matched controls. These findings identify neonatal suppressor T cells as a unique subpopulation separate from most inducible suppressor cells in the adult mouse. The mechanism of action of neonatal suppressor T cells seems to be a reduction in the number of B cells initially triggered by antigen.
D000818:Animals; D000831:Animals, Newborn; D000917:Antibody Formation; D000921:Antibody-Producing Cells; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D005362:Ficoll / Q000276:immunology; D006462:Hemolytic Plaque Technique; D006649:Histocompatibility Antigens; D007106:Immune Sera; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D008934:Mitogens / Q000494:pharmacology; D010641:Phenotype; D013154:Spleen / Q000166:cytology; D013489:Suppression, Genetic; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000166:cytology; D014301:Trinitrobenzenes / Q000276:immunology; D014713:Viruses, Unclassified
D006649:Histocompatibility Antigens; D007106:Immune Sera; D008934:Mitogens; D014301:Trinitrobenzenes; D005362:Ficoll