Effect of vitamin A deficiency on rat hepatic and colon epoxide hydrase.
Rat liver microsomes and homogenized mucosal linings prepared from vitamin A-supplemented and deficient male rats were used in metabolic studies of 7-3H-styrene oxide. The colon tissue in deficient animals exhibits a significantly higher value of Vmax than the same tissue from vitamin-supplemented animals. The implications of this finding in addition to our earlier observation 10 is discussed in relation to colon carcinoma.
D000818:Animals; D002277:Carcinoma / Q000209:etiology; D003106:Colon / Q000201:enzymology*; D003110:Colonic Neoplasms / Q000209:etiology; D004851:Epoxide Hydrolases / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000201:enzymology; D007700:Kinetics; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D051381:Rats; D014802:Vitamin A Deficiency / Q000150:complications / Q000201:enzymology*
D004851:Epoxide Hydrolases