Levels of the serum amyloid A protein (SAA) in normal persons of different age groups.
Serum amyloid A (SAA) has been implicated by three independent studies to increase in concentration with ageing. The present study measured SAA concentration in 395 samples from 302 healthy individuals ranging in age from 21 to 100 years. The average SAA concentration was 20 microgram/ml, with only five serum samples falling below 5 microgram/ml. SAA concentrations are expressed in terms of cross-reactivity of purified, denatured SAA with anti-AA antibodies, rather than the purified, denatured amyloid fibril protein AA from tissues, which has been used in the past. No age-related increase in SAA concentration was observed in the present study. The average SAA concentration in these normal, healthy individuals was almost a hundred-fold less than values measured in acute phase human serum in a separate study with the same reagents.
D000328:Adult; D000368:Aged; D000375:Aging; D000682:Amyloid / Q000032:analysis*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D000685:Serum Amyloid A Protein / Q000032:analysis*
D000682:Amyloid; D000685:Serum Amyloid A Protein