Sleep deprivation deficits and their reversal by d- and l-amphetamine.
Vigilance performance, waking EEG patterns and mood were studied before and after one night of sleep deprivation in normal males. The effects of d-amphetamine 10 mg, l-amphetamine 10 mg and placebo on these measures were compared. Changes were found in all three measures after one night of sleep-deprivation. d-Amphetamine was more powerful than l-amphetamine in reversing sleep deprivation effects on vigilance and on waking EEG.
D000328:Adult; D000661:Amphetamine / Q000494:pharmacology*; D001288:Attention / Q000187:drug effects; D003913:Dextroamphetamine / Q000494:pharmacology*; D004569:Electroencephalography; D004644:Emotions / Q000187:drug effects; D006801:Humans; D008297:Male; D012892:Sleep Deprivation; D013997:Time Factors
D000661:Amphetamine; D003913:Dextroamphetamine