[Effect on the body of rats of rations varying in protein content in acrylomitrile poisoning].
The effect of protein of isocaloric rations (10, 18 and 30 per cent of the total calorific value) differing in its proportion on the course of a subacute poisoning provoked by the acrylic acid nitrile (AAN) in a concentration of 9.7 +/- 2.8 mg/m3 was studied. A comparative study of the results obtained showed that a protein-rich ration produced a more pronounced protective effect. Against its background the AAN metabolites were eliminated from the organism more intensively. This effect could have been occasioned by an excessive supply to the organism together with the additional protein of free sulphur and of SH-group necessary for rendering the cyanides harmless. Considering the results obtained and with the view of a more effective prevention of the AAN poisoning it is advisable to recommend providing workers with a protein-rich medico-prophylactic ration containing an assortment of food products rich in sulphur-containing elements.
D000181:Acrylonitrile / Q000506:poisoning*; D000208:Acute Disease; D000818:Animals; D004044:Dietary Proteins / Q000008:administration & dosage* / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D004781:Environmental Exposure; D004789:Enzyme Activation / Q000187:drug effects; D009570:Nitriles / Q000506:poisoning*; D051381:Rats; D013997:Time Factors
D004044:Dietary Proteins; D009570:Nitriles; D000181:Acrylonitrile
Izuchenie vliianiia na organizm krys razlichnykh po soderzhaniiu belka ratsionov pri intoksikatsii nitrilom akrilovoĭ kisloty.