title: Membrane phospholipid composition and anaphylactical response of cardiac and smooth muscle fibers in the Rh (D) system.
abstract: The anaphylactical response of sensitized smooth and cardiac papillary muscle fibers as target organs was induced by the stimulation of the complement systems in the antigen-antibody reaction of albumin and anti-albumin. However in the Rh (D) system anaphylaxis was only elicited on smooth muscle segments with the corresponding antigen. This discrepancy between both immune systems cannot be explained only by the fact the Rh (D) anti-D reaction does not stimulate the complement activity. Since this antigen-antibody reaction requires a protein phospholipid interaction, the failure of anaphylactical response on cardiac muscle fibers may be due to its phospholipid environment which differed considerably from that of the smooth muscle fibers. Besides the differences in composition and amount of the phospholipids the fatty acid distribution of phosphatidylethanolamine, phosphatidylcholine, sphingomyelin, cardiolipin derived from cardiac or smooth muscle membranes varied clearly. This may influence the protein phospholipid interaction which is essential for the antigen-antibody reaction of the Rh (D) system.
mesh_terms: D000707:Anaphylaxis / Q000276:immunology / Q000503:physiopathology*; D000818:Animals; D002849:Chromatography, Gas; D005227:Fatty Acids / Q000032:analysis; D005260:Female; D006168:Guinea Pigs; D006321:Heart / Q000503:physiopathology; D007082:Ileum / Q000032:analysis; D066298:In Vitro Techniques; D008566:Membranes / Q000032:analysis; D009119:Muscle Contraction; D009130:Muscle, Smooth / Q000032:analysis / Q000276:immunology* / Q000503:physiopathology; D009200:Myocardial Contraction; D009206:Myocardium / Q000032:analysis / Q000276:immunology*; D010210:Papillary Muscles / Q000032:analysis; D010743:Phospholipids / Q000032:analysis*; D012204:Rh-Hr Blood-Group System; D014590:Uterine Contraction; D014599:Uterus / Q000032:analysis
chemical_list: D005227:Fatty Acids; D010743:Phospholipids; D012204:Rh-Hr Blood-Group System