Protein and RNA synthesis in kainic acid-injected striata.
Injections of kainic acid into rat neostriata destroy neuronal soma in the injected area. Kainic acid-injected neostriata show a significant increase (as compared with control) in the incorporation in vitro of label from radioactive leucine into the TCA-insoluble protein fraction at all time periods studied (from 1 to 80 days after the kainic acid injection), with the greatest stimulation ((6-7-fold) occurring between the third and eighth day. At 1-5 days there was also increased incorporation in vitro of label from uridine into RNA. The increased protein synthesis is probably due to the astrocytes which invade the injected area and are still seen in electron microscopic studies 2-3 months after the injections.
D000818:Animals; D002245:Carbon Dioxide / Q000378:metabolism; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D007608:Kainic Acid / Q000494:pharmacology*; D007930:Leucine / Q000378:metabolism; D008970:Molecular Weight; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D010101:Oxygen Consumption / Q000187:drug effects; D011759:Pyrrolidines / Q000494:pharmacology*; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D014529:Uridine / Q000378:metabolism
D009419:Nerve Tissue Proteins; D011759:Pyrrolidines; D002245:Carbon Dioxide; D012313:RNA; D007930:Leucine; D007608:Kainic Acid; D014529:Uridine