Aurosomes produced in the synovial membrane by the oral administration of a gold compound SK & F 36914.
Chlorotriethylphosphine gold (SK & F 36914) administered orally to rabbits produced aurosomes in the synovial membrane. These aurosomes were similar to aurosomes produced by parenteral or intra-articular injections of soluble gold salts such as sodium aurothiomalate and aurothioglucose. This study shows, (1) that an orally administered gold compound is capable of producing gold deposits in the synovial membrane, and (2) that such compounds may have a future in the treatment of rheumatoid arthritis.
D000284:Administration, Oral; D000818:Animals; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000473:pathology; D006046:Gold / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008247:Lysosomes / Q000187:drug effects*; D008854:Microscopy, Electron; D009943:Organophosphorus Compounds / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D011817:Rabbits; D013583:Synovial Membrane / Q000187:drug effects* / Q000473:pathology
D009943:Organophosphorus Compounds; D006046:Gold