[An acellular vaccine from Pseudomonas aeruginosa. II. -- Estimate of immuneserum protective effect by measure of bacterial clearance (author's transl)].
The protective antibodies obtained in mice with an acellular vaccine P2 from Pseudomonas aeruginosa have been titered in vivo by a bacterial clearance technique. The kinetics of the bacterial disappearance from the circulating blood were compared in mice which had been vaccinated or had received injection of specific serum, and in normal mice. The following results were obtained; (a) the disappearance of the bacteria from the blood is quicker in immunized animals; (b) the rate of bacteria in the blood depends on doses of injected serum; (c) the titers of protective antibodies expressed by 99% clearance dose is directly in relation with the vaccinating dose.
D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis*; D001428:Bacterial Vaccines / Q000008:administration & dosage; D008297:Male; D051379:Mice; D011552:Pseudomonas Infections / Q000517:prevention & control*; D011550:Pseudomonas aeruginosa / Q000276:immunology*; D018805:Sepsis / Q000382:microbiology; D014611:Vaccination
D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines
Vaccin acellulaire de Pseudomonas aeruginosa. II. -- Estimation du pouvoir protecteur d'un immunsérum par une mesure de la clairance bactérienne.