[Prophylaxis of Rh-sensitisation by intravenous IgG anti-D (author's transl)].
During 1971 and 1972 1109 rh-negative mothers with an Rh-positive child were treated with an intravenous standard dose of 80-120 microng of IgG anti-D. To achieve complete elimination of fetal erythrocytes within 72 hours after the first immunoglobulin injection this standard dose had to be increased in 14% of the women. In 1973 and 1974 1138 rh-negative mothers of Rh-positive children were treated with an intravenous standard dose of 240 microng of IgG anti-D. This dose was insufficient in only 1.2% of the rh-negative mothers. More than 98.8% of all women are protected by a standard intravenous dose of 240 microng of IgG anti-D and a single erythrocyte elimination control 72 hours after the birth. It appears that the results after intravenous immunoglobulin are as a whole significantly better than after intramuscular IgG anti-D.
D000017:ABO Blood-Group System; D004899:Erythroblastosis, Fetal / Q000517:prevention & control*; D005260:Female; D005312:Fetal Blood; D005319:Fetal Hemoglobin; D006801:Humans; D007112:Immunity, Maternally-Acquired; D007117:Immunization, Secondary; D007074:Immunoglobulin G / Q000008:administration & dosage* / Q000627:therapeutic use; D007231:Infant, Newborn; D007275:Injections, Intravenous; D011247:Pregnancy; D012204:Rh-Hr Blood-Group System
D000017:ABO Blood-Group System; D007074:Immunoglobulin G; D012204:Rh-Hr Blood-Group System; D005319:Fetal Hemoglobin
Prophylaxe der Rhesus-Sensibilisierung durch intravenöse Gabe von Immunglobulin G Anti-D