Metoprolol and the peripheral platelet count.
An acute oral administration of 50 mg metoprolol (a selective beta-1-receptor antagonist) to 18 healthy volunteers induced a significant increase in the peripheral platelet concentration lasting more than 4 h. It is suggested that this increment in the platelet count originates from the exchangeable splenic platelet pool. The mechanism by which metoprolol exerts its effect remains to be established.
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D001772:Blood Cell Count; D001792:Blood Platelets / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008790:Metoprolol / Q000008:administration & dosage / Q000494:pharmacology*; D008875:Middle Aged; D011412:Propanolamines / Q000494:pharmacology*; D013997:Time Factors
D011412:Propanolamines; D008790:Metoprolol