[Implication of GABA in the spatial organization of the receptive fields of retinal ganglia cells of frogs].
An histoautoradiographic study of the Chicken and Frog retinae was made following an intravitreal injection if tritiated GABA. This amino acid was especially fixed at the amacrine and horizontal cell level. It has been suggested (Werblin, 1974) that horizontal cells might be responsible for the spatial organization of the receptive fields of retinal ganglion cells. GABA could thus be involved in bringing about of the centre-surround arrangement of the latter receptive fields. We have shown that picrotoxin, a specific GABA-antagonist, does indeed provoke marked changes in the activity of retinal ganglion cells. It provokes a decrease in the response threshold, a facilitation of spontaneous activities, and a marked increase in the receptive field area of the ON-OFF ganglion cells: from 12 at the start, it reaches 24 under the effect of picrotoxin.
D000613:Aminobutyrates / Q000494:pharmacology*; D000818:Animals; D001001:Anura; D001345:Autoradiography; D001665:Binding Sites; D002645:Chickens; D018756:GABA Antagonists; D005724:Ganglia / Q000187:drug effects; D009433:Neural Inhibition / Q000187:drug effects; D010852:Picrotoxin / Q000494:pharmacology; D011896:Rana temporaria; D012160:Retina / Q000187:drug effects* / Q000378:metabolism; D014794:Visual Fields / Q000187:drug effects*; D014795:Visual Pathways / Q000187:drug effects; D014796:Visual Perception / Q000187:drug effects; D005680:gamma-Aminobutyric Acid / Q000378:metabolism / Q000494:pharmacology*
D000613:Aminobutyrates; D018756:GABA Antagonists; D010852:Picrotoxin; D005680:gamma-Aminobutyric Acid
Implication du gaba dans l'organisation spatiale des champs récepteurs des cellules ganglionnaires de la rétine de grenouille