[Antiarrhythmic and electrophysiological properties of etmozin and its diethylamine analog].
Effects of antiarrhythmic drug etmosin and its diethylamine analogue (etmosin DAA) were compared in dogs with the ventricular rhythm disturbances induced by coronary artery ligation according to Harris' method. As demonstrated, both drugs stopped ventricular rhythm disturbances, but etmosin DAA had a more rapid and prolonged effect. Electrophysiological properties of etmosin and etmosin DAA were studied by the method of potential fixation on trabeculae of frog atria. Both drugs proved to reduce rapid sodium inflow, etmosin DAA acting more intensively and longer. Taking into account the high antiarrhythmic activity of etmosin DAA it is believed that this drug had good prospects for further investigation.
D000818:Animals; D000889:Anti-Arrhythmia Agents; D001001:Anura; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004594:Electrophysiology; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects; D008564:Membrane Potentials / Q000187:drug effects; D009025:Morpholines / Q000627:therapeutic use*; D009203:Myocardial Infarction / Q000188:drug therapy; D010640:Phenothiazines / Q000627:therapeutic use*; D011898:Ranidae; D012964:Sodium / Q000378:metabolism; D013997:Time Factors; D014693:Ventricular Fibrillation / Q000188:drug therapy
D000889:Anti-Arrhythmia Agents; D007473:Ion Channels; D009025:Morpholines; D010640:Phenothiazines; D012964:Sodium
Antiaritmicheskie i élektrofiziologicheskie svoĭstva étmozina i ego diétilsminovogo analoga.