title: [Duration and intensity of postvaccinal immunity to plague in experimental animals].
abstract: Experiments were conducted on guinea pigs and Papio hamadryas; it was shown that a reduction of the intensity of postvaccinal immunity occurred at various periods after a single vaccination. In inhalation method of immunization in guinea pigs it decreased in 6 months 135 times, in monkeys in one year--133 times. However, at the mentioned periods vaccination provided protection of 50% of the animals from infection with Past. pestis in a dose constitutin 20 to 25 aerosol LD50 for nonimmunized animals. Despite the more pronounced (57--640 times) reduction of the intensity of immunity than in the animals vaccinated by inhalation, in the subcutaneously vaccinated guinea pigs in subcutaneously infected with Past. pestis protection level remained high (resistance index in 3 and 6 months constituted 37.10(6) and 3-3-10(6), respectively).
mesh_terms: D000336:Aerosols; D000818:Animals; D006168:Guinea Pigs; D000882:Haplorhini; D007109:Immunity; D007279:Injections, Subcutaneous; D010215:Papio; D010930:Plague / Q000276:immunology / Q000517:prevention & control*; D010931:Plague Vaccine / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D000336:Aerosols; D010931:Plague Vaccine
vernacular_title: Dlitel'nost' i napriazhennost' postvaktsinal'nogo immuniteta k chume v eksperimente na zhivotnykh.