The effects of metiamide on cell-mediated immune reactions in the guinea-pig.
1 The effects of the H2-receptor antagonist, metiamide, on two types of cell-mediated immune response in vivo was investigated in the guinea-pig, in a test of the hypothesis that H2-receptor antagonists would result in 'runaway' unregulated hypersensitivity reactions. 2 Metiamide in doses of 5 mg-125 mg/kg given by 6-hourly injection during sensitization and challenge did not modify the delayed hypersensitivity reaction to tuberculin. 3 Metiamide in doses of 25-125 mg/kg given by injection, 6-hourly throughout sensitization to dinitrofluorobenzene (DNFB) and subsequent challenge six days later, did not modify the contact sensitivity reaction to DNFB. 4 It is concluded that metiamide, given during these cell-mediated immune reactions in the guinea-pig, does not enhance cell-mediated hypersensitivity responses.
D000818:Animals; D004139:Dinitrofluorobenzene / Q000276:immunology; D005260:Female; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000503:physiopathology; D007111:Immunity, Cellular / Q000187:drug effects*; D008785:Metiamide / Q000494:pharmacology*; D009169:Mycobacterium tuberculosis / Q000276:immunology; D012882:Skin Tests; D013890:Thiourea / Q000031:analogs & derivatives*
D008785:Metiamide; D004139:Dinitrofluorobenzene; D013890:Thiourea