title: [Interaction of 2,6-dimethyl-3,5-dicarbethoxy-1,4-dihydropyridine with enzymes of the NADP.H2-specific electron transport chain of rat liver microsomes].
abstract: 2,6-Dimethyl-3,5-dicarboethoxy-1,4-dihydropyridine (DHP) interacts with NADPH-dependent electron transfer system of rat liver microsomes: it forms a complex with the terminal oxidase-cytochrome P-450, according to type I, and inhibits clearly the activity of NADPH-cytochromes c-reductase and mitindione dimethylesterase. DHP repeatedly administered in vivo rendered no inducing influence upon the microsomal enzymes.
mesh_terms: D000815:Aniline Hydroxylase / Q000378:metabolism; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D003579:Cytochrome Reductases / Q000037:antagonists & inhibitors*; D003580:Cytochromes / Q000378:metabolism*; D003997:Dicarbethoxydihydrocollidine / Q000031:analogs & derivatives; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology* / Q000378:metabolism; D009251:NADPH-Ferrihemoprotein Reductase / Q000037:antagonists & inhibitors*; D011725:Pyridines / Q000494:pharmacology*; D051381:Rats
chemical_list: D003580:Cytochromes; D011725:Pyridines; C015160:etidin; D003997:Dicarbethoxydihydrocollidine; D003577:Cytochrome P-450 Enzyme System; D000815:Aniline Hydroxylase; D003579:Cytochrome Reductases; D009251:NADPH-Ferrihemoprotein Reductase
vernacular_title: Vzaimodeĭstvie 2,6-dimetil-3,5-dikarbetoksi-1,4-digidropiridina s fermentami NADF.H2-spetsifichnoĭ tsepi perenosa élektronov mikrosom pecheni krys.