Reduced dose of Rh immunoglobulin following first trimester pregnancy termination.
The efficacy and safety of a 50-microgram dose of Rh immune globulin for prevention of Rh isosensitization following first trimester vacuum abortion are evaluated in this study. A total of 1027 women undergoing abortion at three outpatient facilities participated in the study; 755 (73.5%) completed follow-up serologic screening 6 months after termination of pregnancy. None showed serologic evidence of Rh sensitization at the time of followup. No serious adverse reactions to the drug were observed.
D000028:Abortion, Induced; D000022:Abortion, Spontaneous; D000293:Adolescent; D000328:Adult; D000917:Antibody Formation; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007136:Immunoglobulins / Q000008:administration & dosage*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D012204:Rh-Hr Blood-Group System; D014620:Vacuum Extraction, Obstetrical
D007136:Immunoglobulins; D012204:Rh-Hr Blood-Group System