Production of pancreatic acinar cell carcinoma by combined administration of 4-hydroxyaminoquinoline 1-oxide and azaserine in partial pancreatectomized rats.
The effect of azaserine on the pancreatic tumorigenesis of 4-hydroxyaminoquinoline 1-oxide (4-HAQO) after partial pancreatectomy in rats was studied. Pancreatic acinar cell carcinomas were produced in 7 out of 10 rats (70%), which received 7 mg/kg body wt. 4-HAQO 3 days after partial pancreatectomy, followed by 10 weekly injections of 30 mg/kg body wt. azaserine. Partial pancreatectomy enhanced the carcinogenesis of 4-HAQO, which was further promoted by azaserine.
D015108:4-Hydroxyaminoquinoline-1-oxide / Q000633:toxicity*; D000634:Aminoquinolines / Q000633:toxicity*; D000818:Animals; D001377:Azaserine / Q000633:toxicity*; D002277:Carcinoma / Q000139:chemically induced* / Q000473:pathology; D004357:Drug Synergism; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced; D010179:Pancreas / Q000502:physiology; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000139:chemically induced* / Q000473:pathology; D051381:Rats; D012038:Regeneration
D000634:Aminoquinolines; D015108:4-Hydroxyaminoquinoline-1-oxide; D001377:Azaserine