Metabolism of arylacetic acids. 2. The fate of [14C]hydratropic acid and its variation with species.
1. (+/-)-[methyl-14C]-Hydratropic acid was administered to man, rhesus monkey, cat, rabbit and fruit bat. 2. All species excreted 60-100% of administered 14C in the urine in 24 h, and unchanged hydratropic acid accounted for 0-17% of the dose. 3. In man, the urinary 14C consisted of a very small quantity (1%) of unchanged hydratropic acid with the remainder as hydratropylglucuronide. 4. Hydratropylglucuronide was the major urinary excretion product in the 4 animal species, while the glycine conjugate was present in the urine of cat and rat. Additionally, cats excreted the taurine conjugate of hydratropic acid. 5. Bile-duct cannulated rats excreted 20-30% of an injected dose of [14C] hydratropic acid in the bile in 3 h mainly as hydratropylglucuronide.
D000818:Animals; D001646:Bile / Q000378:metabolism; D002415:Cats; D005965:Glucuronates / Q000652:urine; D005973:Glutamine / Q000652:urine; D005998:Glycine / Q000652:urine; D000882:Haplorhini; D006801:Humans; D008253:Macaca mulatta; D010666:Phenylpropionates / Q000378:metabolism*; D011817:Rabbits; D051381:Rats; D013045:Species Specificity; D013654:Taurine / Q000652:urine
D005965:Glucuronates; D010666:Phenylpropionates; D005973:Glutamine; D013654:Taurine; D005998:Glycine