Morphine and shuttle-box self-stimulation in the rat: a model for euphoria.
In a shuttle-box self-stimulation paradigm, analgesic doses of morphine increase the amount of time a rat leaves rewarding brain stimulation on, without altering average OFF times. This paradigm may serve as a model for the euphoria induced by narcotic drugs and as a useful tool for evaluating the reinforcing effects of drugs.
D000818:Animals; D004558:Electric Stimulation; D005059:Euphoria / Q000187:drug effects*; D005260:Female; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D051381:Rats; D012653:Self Stimulation / Q000187:drug effects*; D013997:Time Factors
D009020:Morphine