title: Subcorneal pustular dermatosis and crippling arthritis.
abstract: A 25-year-old woman has suffered with subcorneal pustular dermatosis and a rheumatoid-like arthritis for the past 11 years. Both her skin lesions and arthralgia have abated with institution of dapsone administration and have worsened with interruption or reduction of the dose. The coexistence of arthritis  and subcorneal pustular dermatosis and the response of both to therapy suggest a probable association.
mesh_terms: D000328:Adult; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D003622:Dapsone / Q000627:therapeutic use; D005260:Female; D006801:Humans; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000150:complications* / Q000188:drug therapy / Q000473:pathology
chemical_list: D003622:Dapsone