title: A study of the reaction of human tissue to proplast.
abstract: The femoral stems of Thompson prostheses coated with a polytetrafluoroethylene/carbon fiber composite (proplast) were studied using conventional histological examination, scanning electron microscopy and electron probe microanalysis in "successful" firm implants and in a "loose" clinically unsuccessful implant. Ingrowth was found throughout the coatings of the successful prostheses. In the most firmly fixed prosthesis the ingrowth consisted of fibrous tissue with abundant giant cells; however, no bone ingrowth was detected. There was less composite pore infilling in the unsuccessful implant. From both clinical, radiological and the studies described above, it is concluded that fibrous tissue ingrowth was a secondary stabilizing phenomenon in the proplast-coated prostheses studied.
mesh_terms: D000368:Aged; D001672:Biocompatible Materials / Q000032:analysis / Q000494:pharmacology*; D001853:Bone Marrow / Q000033:anatomy & histology / Q000187:drug effects* / Q000648:ultrastructure; D002118:Calcium / Q000032:analysis; D002244:Carbon / Q000032:analysis / Q000494:pharmacology*; D004577:Electron Probe Microanalysis; D005260:Female; D005269:Femur / Q000033:anatomy & histology / Q000187:drug effects*; D006621:Hip Joint; D006801:Humans; D007595:Joint Prosthesis; D008297:Male; D010758:Phosphorus / Q000032:analysis; D011138:Polytetrafluoroethylene / Q000032:analysis / Q000494:pharmacology*; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D010758:Phosphorus; D002244:Carbon; D011138:Polytetrafluoroethylene; D002118:Calcium