[Effects of salicylate on the electrical properties of the proximal convoluted tubule of Necturus maculosus].
The effects of peritubular salicylate for chloride substitution were studied in the isolated perfused Necturus kidney. This substitution resulted in changes of cell membrane p.d., varying from tubule to tubule; the withdrawal of the test-anion invariably produced a steep and prolonged depolarization. Exposure of the tissue to salicylate brought about, in addition, electrical uncoupling of junctional membranes, which was not related to concomitant changes of membrane p.d.
D000818:Animals; D002462:Cell Membrane / Q000502:physiology; D007687:Kidney Tubules, Proximal / Q000187:drug effects / Q000502:physiology*; D008564:Membrane Potentials / Q000187:drug effects; D012980:Sodium Salicylate / Q000494:pharmacology*; D014562:Caudata
D012980:Sodium Salicylate
Effets du salicylate sur les propriétés électriques du tube contourné proximal du Necturus maculosus.