Preparation and properties of derivatives of virginiamycin S.
Reduction of virginiamycin S with sodium borohydride produces allo- and normal-dihydro-virginiamycin S. Reduction of the tosylhydrazone of virginiamycin S with sodium cyanoborohydride affords deoxyvirginiamycin S. These compounds are less active than virginiamycin S. Like virginiamycin S they enhance the activity of virginiamycin M1.
D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D004352:Drug Resistance, Microbial; D004357:Drug Synergism; D006868:Hydrolysis; D010084:Oxidation-Reduction; D013329:Structure-Activity Relationship; D014769:Virginiamycin / Q000494:pharmacology
D014769:Virginiamycin