[Pathologic processes as factors influencing the genotypic structure of populations].
Pathological processes, which take place in a population, can play an important role in the determination of the genotypical structure of the population. It is demonstrated by the analysis of a relation between blood genotypical markers and children lethality. It is found that the summary elimination of A+A+AB phenotypes with respect to O phenotype in ABO system reliably differs only within 1--6 months, and in MN system (the elimination of M phenotype)--only within the period of mortinatality. Certain preference of heterozygous genotypes for the MN system at this period is observed, which is the first case studied for normal features of humans. The elimination of rhesus-negative phenotypes is observed for the rhesus system at all the ontogenesis stages studied. A problem of isolating a genotypical component, which takes place on children lethality, is discussed. It solution will open an efficient prophylaxis of children lethality.
D000017:ABO Blood-Group System; D001789:Blood Group Antigens; D002648:Child; D002675:Child, Preschool; D005828:Genetics, Population; D006801:Humans; D007223:Infant; D007226:Infant Mortality; D007231:Infant, Newborn; D008951:MNSs Blood-Group System; D009026:Mortality; D012204:Rh-Hr Blood-Group System
D000017:ABO Blood-Group System; D001789:Blood Group Antigens; D008951:MNSs Blood-Group System; D012204:Rh-Hr Blood-Group System
Patologicheskie protsessy kak faktor, vliiaiushchiĭ na genotipicheskuiu strukturu populiatsii.