Screening of organic acids in urine by chemical ionization mass spectrometry.
A method has been developed for qualitative screening of carboxylic acids in human urine. The method uses direct chemical inoization mass spectrometry with isobutane as reagent gas. The carboxylic acids are separated from the urine samples by ion exchange. Normal carboxylic acid profiles have been determined and are compared with the profiles of patients suffering from certain metabolic disorders.
D000596:Amino Acids / Q000652:urine; D002264:Carboxylic Acids / Q000652:urine*; D002648:Child; D002675:Child, Preschool; D002852:Chromatography, Ion Exchange; D006801:Humans; D006880:Hydroxy Acids / Q000652:urine; D007231:Infant, Newborn; D008375:Maple Syrup Urine Disease / Q000652:urine; D013058:Mass Spectrometry / Q000379:methods*; D010661:Phenylketonurias / Q000652:urine; D012202:Reye Syndrome / Q000652:urine
D000596:Amino Acids; D002264:Carboxylic Acids; D006880:Hydroxy Acids