title: [Effect of a 49-day space flight on immunological reactivity indices and on the blood protein makeup in the crew of Saliut-5].
abstract: The prolonged 49-day space flight resulted in a significant inhibition of immunological reactivity of the Salyut-5 crewmembers which involved a decline in bactericidal activity of the serum and lysozyme activity of the saliva, and a decrease in the content of immunoglobulins in the saliva and tonsillary lacunae. After the flight recovery of reduced immunoreactivity took a longer time than after shorter-term flights. The prolonged space mission led to an increase of most globulin fractions and a decrease of albumin in blood. With respect to globulin fractions, a predominant increase in the content of C3c and C4-factors of the complement and immunoglobulins G, A, M was noted. Blood proteins returned to normal within a long period of time.
mesh_terms: D000937:Antigen-Antibody Reactions; D001798:Blood Proteins / Q000032:analysis*; D003165:Complement System Proteins / Q000032:analysis; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D014066:Palatine Tonsil / Q000276:immunology; D012463:Saliva / Q000276:immunology; D013026:Space Flight; D013997:Time Factors; D014586:USSR
chemical_list: D001798:Blood Proteins; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D003165:Complement System Proteins
vernacular_title: Vliianie 49-sutochnogo kosmicheskogo poleta na pokazateli immunologicheskoĭ reaktivnosti i belkovyĭ sostav krovi ékipazha "Saliut-5".