title: Odontoblast metabolism in rats deficient in vitamin D and calcium I: A histochemical survey.
abstract: Different rat diets, deficient in calcium and/or vitamin D, were tested for varying experimental periods to obtain changes in serum calcium values, body weight gain and odontoblast-predentine morphology. One diet, R 25, used during a 14-day period, was found to induce lowered serum calcium values and an increased predentin width in incisor teeth. Rats fed this diet demonstrated an increase in alkaline phosphatase and ATP-splitting enzyme activity in dentinogenically active incisor odontoblasts. No other metabolic changes in these cells were demonstrated by the histochemical methods employed.
mesh_terms: D000818:Animals; D002118:Calcium / Q000097:blood / Q000172:deficiency*; D004032:Diet; D006651:Histocytochemistry; D008297:Male; D009804:Odontoblasts / Q000201:enzymology / Q000378:metabolism*; D010710:Phosphates / Q000097:blood; D051381:Rats; D014808:Vitamin D Deficiency / Q000378:metabolism*
chemical_list: D010710:Phosphates; D002118:Calcium