title: [Bone lesions in a case of heavy chain alpha disease (author's transl)].
abstract: Specific bone lesions are not usually found in heavy chain alpha disease we report a case in which images identical to those seen in Parker and Jackson's sarcoma (bone lymphoma) were found. The malignant lymphomatous nature of the lesion could not be confirmed as a bone biopsy was not made, but its regression under chemotherapy makes the diagnosis almost certain. Indirectly, arguments in favour of this hypothesis can be drawn from the common cellular origin of bone lymphomas and monoclonal gammopathies. Furthermore, it is logical to assume that heavy chain alpha disease, as with most other immuno-proliferative syndromes, can be associated with malignant lymphomatous changes in the skeleton.
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000276:immunology*; D006362:Heavy Chain Disease / Q000150:complications* / Q000000981:diagnostic imaging; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000032:analysis; D007137:Immunoglobulin alpha-Chains / Q000032:analysis; D008223:Lymphoma / Q000000981:diagnostic imaging / Q000276:immunology*; D008297:Male; D011859:Radiography
chemical_list: D007143:Immunoglobulin Heavy Chains; D007137:Immunoglobulin alpha-Chains
vernacular_title: Lésions osseuses dans une maladie des chaînes lourdes alpha. A propos d'une observation.