title: Effects of ischemia on the oxygen diffusion coefficients in the brain cortex (studies on Macaca irus).
abstract: In this series of experiments changes in oxygen diffusion coefficients were measured in waking primates undergoing focal middle cerebral artery ischemia; Ligation of the middle cerebral artery followed by a decrease of the oxygen diffusion coefficient in the areas supplied by that vessel to levels ten to twenty per cent below normal by twenty-five minutes following onset of ischemia. Following release and re-perfusion diffusion coefficient gradually increases and reaches a super normal peak value three hours after release of ligation. This is followed by a gradual reduction in diffusion coefficient with stabilization at preocclusion levels. In the three experiments described these changes following re-perfusion corresponded with clinical improvement of the neurological status of the monkeys;
mesh_terms: D000818:Animals; D001692:Biological Transport; D002540:Cerebral Cortex / Q000098:blood supply*; D004058:Diffusion; D000882:Haplorhini; D002546:Ischemic Attack, Transient / Q000378:metabolism*; D007700:Kinetics; D008251:Macaca; D010100:Oxygen / Q000032:analysis; D010101:Oxygen Consumption
chemical_list: D010100:Oxygen