Hypotensive activity of sodium nitroprusside and structurally related complexes of sodium pentacyanoamine ferrate with amylnitrite, butylnitrite and n-octylamine.
Complexes of sodium pentacyanoamine ferrate (TPF) with amylnitrite and with butylnitrite showed hypotensive activity equal to that of sodium nitroprusside, as tested intravenously, in unanesthetized , instrumented Rhesus, monkeys. The complex with n-octylamine, on the other hand, had significantly lower activity. These complexes produced only marginal hypotensive effects when administered orally in a dose of 10 mg/kg to spontaneously hypertensive rats.
D000284:Administration, Oral; D000588:Amines / Q000008:administration & dosage / Q000494:pharmacology*; D000680:Amyl Nitrite / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D003486:Cyanides / Q000008:administration & dosage / Q000494:pharmacology; D004338:Drug Combinations; D005292:Ferricyanides / Q000494:pharmacology*; D000882:Haplorhini; D007275:Injections, Intravenous; D008253:Macaca mulatta; D008297:Male; D009573:Nitrites / Q000008:administration & dosage / Q000494:pharmacology*; D009599:Nitroprusside / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats
D000588:Amines; D003486:Cyanides; D004338:Drug Combinations; D005292:Ferricyanides; D009573:Nitrites; D009599:Nitroprusside; D000680:Amyl Nitrite