Inhibitor(s) of prostaglandin biosynthesis and epidermal injury.
Inhibition of the activity of sheep vesicular gland prostaglandin synthetase (a rare limiting enzyme in the biosynthesis of prostaglandins) was demonstrated in the presence of homogenates prepared from skin lesions characterized histologically by epidermal disruption. These inhibitory effects were not observed in homogenates of skin lesions characterized by a lack of epidermal disruption.
D000818:Animals; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*; D011453:Prostaglandins / Q000096:biosynthesis*; D012756:Sheep; D012867:Skin / Q000201:enzymology*; D012871:Skin Diseases / Q000201:enzymology / Q000378:metabolism*; D012883:Skin Ulcer / Q000201:enzymology
D011453:Prostaglandins; D006899:Mixed Function Oxygenases; D011451:Prostaglandin-Endoperoxide Synthases