Occurrence of haemoglobin H in leukaemia: a further case of erythroleukaemia.
Erythroleukaemia in an elderly Caucasian male was associated with the presence of 15% of haemoglobin H (Hb-H; Hb-beta4) in the haemolysate, identified by electrophoretic analysis, isolation and 'finger-printing'. The peripheral blood picture was dimorphic, with 40% of hypochromic and morphologically abnormal red cells. Inclusion bodies indicative of the presence of Hb-H occurred in 30% of the red cells after supravital staining. The rare occurrence of Hb-H in leukaemic conditions and its distribution in the red cells is discussed in relation to the possible clonal origin of leukaemia and the involvement of red cell precursors.
D000368:Aged; D004912:Erythrocytes / Q000648:ultrastructure; D006447:Hemoglobin H / Q000032:analysis; D006801:Humans; D004915:Leukemia, Erythroblastic, Acute / Q000097:blood*; D008297:Male
D006447:Hemoglobin H