Synergism of penicillin and gentamicin against Listeria monocytogenes in ex vivo hemodialysis culture.
A new technique of ex vivo hemodialysis culture was used to study the effects against Listeria monocytogenes of penicillin G and gentamicin administered intra-muscular, singly and in combination, in the goat. Bactericidal synergism of the combination was detected despite rapidly diminishing concentrations of the drugs in the blood plasma and dialysate.
D000818:Animals; D004357:Drug Synergism; D005839:Gentamicins / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D006041:Goats; D007273:Injections, Intramuscular; D008089:Listeria monocytogenes / Q000187:drug effects*; D010400:Penicillin G / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D006435:Renal Dialysis; D013997:Time Factors
D005839:Gentamicins; D010400:Penicillin G