title: [Treatment of advanced breast cancer with alkylating agents].
abstract: The results obtained in 26 patients suffering from metastatic cancer of the breast no longer sensitive to hormone treatment are reported. The patients were treated with ciclophosphamide (CTX) (500 mg i.v.) once a week and triethylenethiophosphamide (20-30 mg i.m.) (TSPA) every 4 weeks associated with cyclophosphamide as follows: CTX--CTX--CTX--CTX+TSPA. 9 objective regressions (34.6%) were observed. Those with objective regression lived 28 months on average (SD 23.45) and those without lived on average 11.41 months (SD 9.89). The difference is statistically significant. Side effects of various types were observed in 7 patients (27%).
mesh_terms: D000328:Adult; D000368:Aged; D000477:Alkylating Agents / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D003520:Cyclophosphamide / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008875:Middle Aged; D009362:Neoplasm Metastasis; D012075:Remission, Spontaneous; D013852:Thiotepa / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D000477:Alkylating Agents; D003520:Cyclophosphamide; D013852:Thiotepa
vernacular_title: Trattamento con alchilanti del carcinoma mammario in fase avanzata]