[Dynamics of cellular and humoral immunologic reactions following insulin administration to guinea pigs].
Prolonged daily insulin administration to guinea pigs induced humoral and cellular immunological reactions to insulin; the earliest phenomena were reactions of lymphocyte blast-cell transformation and delayed skin hypersensitivity. Inhibition of macrophage migration and immediate skin hypersensitivity, as well as circulating insulin antibodies appeared later. Following prolonged 3--6 month insulin administration the blast-cell transformation reaction to insulin becomes negative; as to other immunological reactions under study--they displayed sensitization to insulin.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D002465:Cell Movement / Q000187:drug effects; D004342:Drug Hypersensitivity; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed; D006969:Hypersensitivity, Immediate; D007328:Insulin / Q000276:immunology / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects; D011485:Protein Binding; D012867:Skin / Q000276:immunology
D007328:Insulin
Dinamika kletochnykh i gumoral'nykh immunologicheskikh reaktsii pri vvedenii insulina morskim svinkam.