title: The cyclic relationship of estrogen sulfurylation to the nuclear receptor level in human endometrial curettings.
abstract: Human endometrial curettings were selected principally from patients undergoing tubal ligations for elective sterilization. Specimens were analyzed for the metabolism of 17beta-[6,7-3H]estradiol and Na2 35SO4; assayed for the nuclear receptor content with 17beta-[6,7-3H]estradiol; and examined for the cytosol receptor content with 17beta-[2,4,6,7-3H]estradiol. The results of these experiments demonstrated that a) estrogen sulfotransferase activity is greatly stimulated during the secretory phase; b) although estrogen dehydrogenase is active throughout the menstrual cycle, the formation of estrone is elevated in concert with sulfurylation; and c) this increased metabolism of 17beta-estradiol is accompanied by a decreased nuclear uptake of the estrogen receptor complex. The importance of this endometrial estrogen metabolism in the maintenance of a secretory tissue is discussed.
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D004717:Endometrium / Q000378:metabolism*; D004958:Estradiol / Q000378:metabolism*; D005260:Female; D006801:Humans; D008598:Menstruation; D009215:Myometrium / Q000378:metabolism; D010088:Oxidoreductases / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism*; D013464:Sulfuric Acids / Q000378:metabolism*; D013466:Sulfurtransferases / Q000378:metabolism; D013552:Swine
chemical_list: D011960:Receptors, Estrogen; D013464:Sulfuric Acids; D004958:Estradiol; D010088:Oxidoreductases; D013466:Sulfurtransferases