Microsomal hexose-6-phosphate dehydrogenase in injured liver.
Hexose-6-phosphate dehydrogenase (H6PD) in rat liver microsomes was clearly differentiated kinetically, immunologically and electrophoretically from glucose-6-phosphate dehydrogenase (G6PD) localized in liver supernatants. Although the soluble G6PD activity increased upon liver injuries induced by CCl4 and thioacetamide, the H6PD activity decreased markedly 1-2 days following administrations of these hepatotoxins. The specific activity of H6PD remained fairly constant under other experimental conditions where the levels of the soluble G6PD activity increased.
D000429:Alcohol Oxidoreductases / Q000378:metabolism*; D000818:Animals; D000937:Antigen-Antibody Reactions; D002237:Carbohydrate Dehydrogenases; D002252:Carbon Tetrachloride Poisoning / Q000201:enzymology*; D002729:Chloromercuribenzoates / Q000494:pharmacology; D005333:Fetus; D005615:Freezing; D005690:Galactose; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism*; D006600:Hexosephosphates; D005779:Immunodiffusion; D007700:Kinetics; D008115:Liver Regeneration; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D008970:Molecular Weight; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats
D002729:Chloromercuribenzoates; D006600:Hexosephosphates; D000429:Alcohol Oxidoreductases; D002237:Carbohydrate Dehydrogenases; C020552:galactose-6-phosphate dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D005690:Galactose; D010634:Phenobarbital