title: [Effect of sodium aurothiomalate in acute toxic hepatitis].
abstract: The effect of lysosomotropic agent--sodium aurothiomalate on liver damage and lysosomal changes during acute toxic hepatitis was studied. Combined administration of sodium aurothiomalete led to less extensive necrosis and to widening dystrophic areas in the hepatic parenchyma. Solubilization of the acid RNA-ase activity was decreased, and nonsedimentable activities of beta-galactosidase, cathepsin D were the same as in acute CCl4-hepatitis.
mesh_terms: D000208:Acute Disease; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy* / Q000473:pathology; D002403:Cathepsins / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000473:pathology; D005696:Galactosidases / Q000378:metabolism; D006052:Gold Sodium Thiomalate / Q000627:therapeutic use*; D008099:Liver / Q000648:ultrastructure; D008247:Lysosomes / Q000201:enzymology; D008297:Male; D051381:Rats; D012260:Ribonucleases / Q000378:metabolism
chemical_list: D006052:Gold Sodium Thiomalate; D012260:Ribonucleases; D005696:Galactosidases; D002403:Cathepsins
vernacular_title: Osobennosti deĭstviia aurotiomalata natriia pri ostrom toksicheskom gepatite.