title: [Differentiation of an achromatic metastatic human melanoma. Development in vitro and tumorigenicity in nude mice].
abstract: The evolution of the phenotypic expression in vitro of unpigmented human metastatic melanocytes is accompanied by the transitionary disappearance of specific morphological structures, a variation in the mode and ploidy of the cells and a modification in their tumorigenicity.
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D007621:Karyotyping; D008545:Melanoma / Q000235:genetics / Q000473:pathology* / Q000648:ultrastructure; D008547:Melanophores / Q000648:ultrastructure; D051379:Mice; D008875:Middle Aged; D009368:Neoplasm Transplantation; D010858:Pigmentation; D014183:Transplantation, Heterologous
vernacular_title: Différenciation d'un mélanome métastatique achromique humain. Evolution in vitro et tumorigénicité chez la souris "nude".