Gastric hypersecretion after formation of small bowel conduits: a common factor in several clinical states.
As a preliminary step in studying the effect on gastric acid secretion in dogs following biliary diversion through isolated intestinal conduits, blind-ended intestinal conduits were constructed and the biliary channel was left undisturbed at this time. The results were surprising in that a significant absolute increase in gastric acid secretion occurred in all dogs, within the range of 65-286%, by merely disconnecting a segment of small bowel from the mainstream of flow of intestinal contents. This effect may be due to the "intestinal phase of gastric secretion hormone" and may in itself provide a partial explanation for the well-documented increase in gastric acid production caused by the Exalto-Mann-Williamson procedure and by choledochoenterostomy utilizing a Roux loop.
D000818:Animals; D001646:Bile; D003135:Common Bile Duct / Q000601:surgery; D004285:Dogs; D004386:Duodenum / Q000601:surgery; D005750:Gastric Juice / Q000378:metabolism*; D006801:Humans; D007421:Intestine, Small / Q000601:surgery*; D007583:Jejunum / Q000601:surgery; D008722:Methods; D009765:Obesity / Q000628:therapy; D011183:Postoperative Complications