[Ultrastructural study of the hypothalamic region after administration of aurothioglucose in mice].
Aurothioglucose dose of 1 mg g-1 1. w. was applied intraperitoneally to experimental female mice. After 24 hours the animals were decapitated and samples for ultrastructural examination were immediately taken from the region of the hypothalamic ventromedial nucleus. The following findings were obtained from the study of 243 electronograms of 8 experimental animals: 1. dense round particles 0.034 to 0.016 mu in size, representing the gold of aurothioglucose; 2. parenchymatous dystrophy of the mitochondria; 3. peeling off of the individual layers of myelin sheath and the granularity of these layers corresponding to the disintegration of nerve fibres.
D000818:Animals; D006051:Aurothioglucose / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006046:Gold / Q000494:pharmacology*; D007031:Hypothalamus / Q000187:drug effects* / Q000648:ultrastructure; D051379:Mice; D008928:Mitochondria / Q000648:ultrastructure; D009186:Myelin Sheath / Q000648:ultrastructure; D009457:Neuroglia / Q000648:ultrastructure
D006051:Aurothioglucose; D006046:Gold
Ultrastruktúrne pozorovanie hypotalamickej oblasti po aplikácii aurothioglukózy u mysí.