title: [Standardization of chemical cholerogen-toxoid cholera vaccine according to the content of somatic O-antigen].
abstract: The authors discuss the results of studies on the choice of highly-reproducible and sufficiently informative methods of 9-antigen standardization in a new chemical vaccine against cholera (cholerogen-toxoid); materials were collected under conditions of controlled epidemilogical trial. Titration of O-antigen in industrial batches of the preparation with the aid of precipitation in gel against standard O-cholera serum could be used for its standardization. Quantitative limits of O-antigen responsible for the formation of vibration (antimicrobial) antibodies in the persons vaccinated were found by studying the immunogenicity and reactogenicity of a number of cholerogen-toxoid batches contrast by O-antigen content described by means of the precipitation test.
mesh_terms: D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D000942:Antigens, Bacterial / Q000032:analysis; D002771:Cholera / Q000517:prevention & control; D022121:Cholera Vaccines / Q000009:adverse effects / Q000032:analysis / Q000592:standards*; D006801:Humans; D005779:Immunodiffusion; D012703:Serotyping; D013045:Species Specificity; D014121:Toxoids / Q000032:analysis / Q000592:standards; D014611:Vaccination
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D022121:Cholera Vaccines; D014121:Toxoids
vernacular_title: Standartizatsiia khimicheskoĭ kholernoĭ vaksiny kholerogen-anatoksin po soderzhaniiu somaticheskogo O-antigena