Reflex and neuro-humoral pressor action of the hypertonic solutions.
The intraarterial injections of 50% urea or 20% NaCl induced a rise of the systemic arterial blood pressure simultaneously with a constriction of the vessels of the legs. The mechanism which is responsible for these phenomena is very complex. It includes a reflex arising from the arterial wall, which is mediated through the spinal cord, the release of catecholamines and of some still nonidentified pressor substances and a central component which is normally masked by the depressor sinus reflex.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004285:Dogs; D006982:Hypertonic Solutions / Q000494:pharmacology*; D012018:Reflex / Q000187:drug effects*; D012462:Saline Solution, Hypertonic / Q000494:pharmacology; D013116:Spinal Cord / Q000187:drug effects; D014508:Urea / Q000494:pharmacology; D014666:Vasomotor System / Q000187:drug effects*
D006982:Hypertonic Solutions; D012462:Saline Solution, Hypertonic; D014508:Urea