Marijuana, alcohol, and combined drug effects on the time course of glare recovery.
The time course of light adaptation after intense light exposure is significantly delayed by alcohol, marijuana, and a combined dose of alcohol and marijuana. These effects were found in a double blind experiment, using 10 subjects. The experimental treatments were placebo, 0.75 ml/kg of 95% ethanol, 8 and 15 mg of delta9 tetrahydrocannabinol (THC). and 0.75 ml/kg of 95% ethanol together with 15 mg of THC. The marijuana-induced delay in recovery is doserelated. Both drugs produce delayed recovery for at least 2 h after drug ingestion. The combined alcohol and marijuana treatment produces little more than the effect produced by either drug alone, suggesting some antagonism between the drugs--a suggestion supported by a significantly lower blood alcohol level for the alcohol dose when combined with marijuana than when taken alone.
D000221:Adaptation, Ocular / Q000187:drug effects*; D000328:Adult; D002188:Cannabis; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology*; D006801:Humans; D008297:Male; D011680:Pupil / Q000187:drug effects; D013997:Time Factors
D000431:Ethanol