Intraocular pressure control with twice-daily pilocarpine in two vehicle solutions.
In a double-blind study no significant difference was found in intraocular pressure control, mean pressure or comparative binocular intraocular pressure difference between pilocarpine in Adsorbobase compared to pilocarpine in 0.5% hydroxypropl-methylcellulose solution. Intraocular pressure control was achieved on fewer than 60% of visits using pilocarpine twice daily in either of the 2 vehicles. While pilocarpine retained some residual hypotensive effect 12 hours after application, twice-daily dosage with the solutions tested gave inadequate control for clinical usefulness.
D000328:Adult; D000368:Aged; D001548:Benzalkonium Compounds; D002986:Clinical Trials as Topic; D003692:Delayed-Action Preparations; D004334:Drug Administration Schedule; D004492:Edetic Acid; D005069:Evaluation Studies as Topic; D005260:Female; D005901:Glaucoma / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008747:Methylcellulose / Q000031:analogs & derivatives; D008875:Middle Aged; D009883:Ophthalmic Solutions; D014677:Pharmaceutical Vehicles; D010862:Pilocarpine / Q000008:administration & dosage*; D011205:Povidone
D001548:Benzalkonium Compounds; D003692:Delayed-Action Preparations; D009883:Ophthalmic Solutions; D014677:Pharmaceutical Vehicles; D010862:Pilocarpine; C006420:adsorbobase; D008747:Methylcellulose; D004492:Edetic Acid; D011205:Povidone