Ia antigen expression on the developing mouse embryo and placenta.
The expression of I region controlled antigens on the mouse embryo and placenta has been investigated using immuno-peroxidase labelling and a mixed haemadsorption assay. The results indicate that Ia antigens are absent from selected pre- and post-implantation embryonic and trophoblastic tissues and from the trophoblast of the definitive placenta. In contrast, cells derived from the peri-placental maternal decidual tissues are Ia antigen-positive. The findings are discussed in relation to the allograft status of the conceptus and the identity and functional significance of the Ia-bearing maternal cells at the foeto-maternal interface.
D000818:Animals; D004622:Embryo, Mammalian / Q000276:immunology*; D005260:Female; D006382:Hemadsorption; D000949:Histocompatibility Antigens Class II; D007124:Immunoenzyme Techniques; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010920:Placenta / Q000166:cytology / Q000276:immunology*; D011247:Pregnancy; D011947:Receptors, Antigen, B-Cell; D011961:Receptors, Fc; D012397:Rosette Formation
D000949:Histocompatibility Antigens Class II; D011947:Receptors, Antigen, B-Cell; D011961:Receptors, Fc