Diagnosis of haematological disease using anti-i. I. Disorders with lymphocytosis.
Using cytotoxicity and antibody-binding tests, the i antigen was measured on the blood lymphocytes of normal subjects and of patients in whom a diagnosis of chronic lymphocytic leukemia (CLL) was considered because of a slight lymphocytosis in the blood and bone marrow. Among 25 patients, 15 had a normal amount of i antigen; in 10 there was a marked reduction in i antigen, such as is found in typical CLL. Similar studies were done on lymphocytes from 15 patients with clinical and morphological findings usually associated with lymphosarcoma cell leukemia (LSL). Nine had a normal amount of i antigen; in six there was a marked reduction of i antigen, suggesting a diagnosis of CLL. A study of the subsequent clinical course and final diagnosis in these patients suggests that the reduction in lymphocyte i antigen characteristic of typical CLL occurs in patients with early CLL who have only slight lymphocytosis, but not in patients with slight lymphocytosis from other causes. Similarly, a reduction in lymphocyte i antigen is found in patients with morphologically atypical CLL but not in patients with LSL.
D000937:Antigen-Antibody Reactions; D000941:Antigens / Q000032:analysis; D001789:Blood Group Antigens; D003602:Cytotoxicity, Immunologic; D003937:Diagnosis, Differential; D006801:Humans; D007048:I Blood-Group System; D007938:Leukemia / Q000175:diagnosis; D007945:Leukemia, Lymphoid / Q000175:diagnosis*; D008214:Lymphocytes / Q000276:immunology; D008218:Lymphocytosis / Q000175:diagnosis*
D000941:Antigens; D001789:Blood Group Antigens; D007048:I Blood-Group System