Urinary hypoxanthine, xanthine and uric acid excretion in newborn infants with perinatal complications.
The concentration of hypoxanthine, xanthine and uric acid in the first 24-h urine of 105 newborn infants was measured densitometrically by thin-layer chromatography. 45 of them had moderate or severe perinatal complications. Among these newborns, 26 infants with perinatal complications (58%) and 4 infants without perinatal complications (7%) had an elevated urinary excretion rate of hypoxanthine. Urinary xanthine was not increased, uric acid was slightly higher in the group of infants with perinatal complication. It seems that a crucial mark is involved, if the rate of hypoxanthine exceed 15% of the total urinary oxypurine excretion, or, if related to urinary creatinine, more than 0.075 mumol hypoxanthine/mumol creatinine. Apparently, with hypoxic newborns increased values of urinary hypoxanthine excretion can be used to quantify the lack of oxygen retrospectively.
D002855:Chromatography, Thin Layer; D003404:Creatinine / Q000652:urine; D003720:Densitometry; D005260:Female; D005311:Fetal Hypoxia / Q000175:diagnosis* / Q000652:urine; D006801:Humans; D007042:Hypoxanthines / Q000652:urine*; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000652:urine*; D009994:Osmolar Concentration; D010288:Parenteral Nutrition; D011247:Pregnancy; D014527:Uric Acid / Q000652:urine*; D014970:Xanthines / Q000652:urine*
D007042:Hypoxanthines; D014970:Xanthines; D014527:Uric Acid; D003404:Creatinine