title: Effect of insulin on immunological phagocytosis by macrophages.
abstract: It was shown that, in physiological concentrations, insulin enhances, in vitro, the immunological phagocytosis of sensitized sheep erythrocytes by cultured mouse peritoneal macrophages. Insulin seems to stimulate macrophage phagocytosis as a cholinomimetic agonist by increasing the intracellular levels of cyclic GMP.
mesh_terms: D000818:Animals; D001665:Binding Sites; D005260:Female; D007328:Insulin / Q000494:pharmacology*; D007329:Insulin Antagonists; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology / Q000502:physiology; D051379:Mice; D009712:Nucleotides, Cyclic / Q000378:metabolism; D010587:Phagocytosis / Q000187:drug effects*; D013268:Stimulation, Chemical
chemical_list: D007328:Insulin; D007329:Insulin Antagonists; D009712:Nucleotides, Cyclic