[Mutagenic action of platinum and palladium compounds on bacteria].
Platinum complex compounds are shown to cause mutations in S. typhimurium strains, TA-100 and TA-98 bearing plasmid pKM-101 but not in isogenic strains TA-1535 and TA-1538 lacking the plasmid. The mutagenic action depended on the ligand nature in the complex and did not depend on the extent of the central atom oxidation. No mutagenic activity of the palladium compounds tested was found.
D002945:Cisplatin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D009153:Mutagens; D010165:Palladium / Q000494:pharmacology*; D010957:Plasmids / Q000187:drug effects; D010984:Platinum / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000187:drug effects*
D009153:Mutagens; D010984:Platinum; D010165:Palladium; D002945:Cisplatin
Izuchenie mutagennogo deĭstviia soedineniĭ platiny i palladiia na bakterii.