[Quantitative histochemical study of the effect of benzodiazepine tranquilizers on cerebral GABA-transaminase activity].
The effect of diazepam and nitrazepam (0.5, 1, 2.5, and 5 mg/kg) on GABA-transaminase activity in the rat cerebellar cortex and hippocampus was investigated by quantitative histochemistry. Both the drugs suppressed the enzyme activity in the hippocampus; the maximal effect was produced by diazepam. It is suggested that the observed alterations are caused by the enzyme inhibition and also by a decrease of GABA turnover rate.
D000612:4-Aminobutyrate Transaminase / Q000378:metabolism*; D000818:Animals; D002531:Cerebellum / Q000201:enzymology*; D003975:Diazepam / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006624:Hippocampus / Q000201:enzymology*; D006651:Histocytochemistry; D008297:Male; D009567:Nitrazepam / Q000494:pharmacology*; D051381:Rats; D000637:Transaminases / Q000378:metabolism*
D009567:Nitrazepam; D000637:Transaminases; D000612:4-Aminobutyrate Transaminase; D003975:Diazepam
Kolichestvennoe gistokhimicheskoe izuchenie vliianiia benzodiazepinovykh trankvilizatorov na aktivnost' GAMK-transaminazy mozga krys.