[Modeling modification of chemical mutagenesis in human cells. 1. Elimination of chromosomal aberrations].
Elimination of chromosome aberrations was studied in populations of dividing cells. For this purpose, on the basis of the corresponding theory of Carrano-Heddle assuming the Poisson distribution, a theory is advanced by the authors based on geometrical distribution, describing the distribution of lesions caused by the action of tioTEF. Parameters of elimination are obtained observed in case of addition of a protector, aminopropy-laminoethylthiophosphoric acid (APAETF) in a lymphocyte culture of human peripheral blood. It is shown that the addition of the protector diminishes the probability of the transmission of chromosome aberrations to daughter cells.
D002478:Cells, Cultured; D002872:Chromosome Deletion; D006801:Humans; D008214:Lymphocytes; D008433:Mathematics; D008954:Models, Biological; D063086:Organothiophosphates / Q000494:pharmacology*; D009946:Organothiophosphorus Compounds / Q000494:pharmacology*; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D013852:Thiotepa / Q000037:antagonists & inhibitors*
D063086:Organothiophosphates; D009946:Organothiophosphorus Compounds; D011837:Radiation-Protective Agents; D013852:Thiotepa
Modelirovanie modifikatsii khimicheskogo mutageneza v kletkakh cheloveka. Soobshchenie I. Eliminatsiia aberratsiĭ khromosom.