The effect of banol and paraoxon on the NADPH-cytochrome c reductase activity and cytochrome P-450 content in rats.
We investigated the effect of banol and paraoxon on the activity of NADPH-cytochrome c reductase and cytochrome P-450 concentration in microsomes of rats treated in vivo with these compounds alone, or in the presence of phenobarbitone. The results showed that banol reduced the NADPH-cytochrome c reductase activity and the concentration of cytochrome P-450, while paraoxon reduced the activity of NADPH-cytochrome c reductase, but increased the cytochrome P-450 concentration. Phenobarbitone stimulated an increased NADPH-cytochrome c reductase activity and cytochrome P-450 concentration. When applied with banol and paraoxon, phenobarbitone lowered their inhibitory effect.
D000818:Animals; D002219:Carbamates; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D003579:Cytochrome Reductases / Q000378:metabolism*; D004347:Drug Interactions; D005260:Female; D066298:In Vitro Techniques; D007306:Insecticides / Q000494:pharmacology*; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D009251:NADPH-Ferrihemoprotein Reductase / Q000378:metabolism*; D010261:Paraoxon / Q000494:pharmacology*; D010634:Phenobarbital / Q000494:pharmacology; D011506:Proteins / Q000378:metabolism; D051381:Rats; D014992:Xylenes / Q000494:pharmacology
D002219:Carbamates; D007306:Insecticides; D011506:Proteins; D014992:Xylenes; D003577:Cytochrome P-450 Enzyme System; D003579:Cytochrome Reductases; D009251:NADPH-Ferrihemoprotein Reductase; C000241:carbanolate; D010261:Paraoxon; D010634:Phenobarbital