Denervation supersensitivity to noradrenaline in the guinea-pig vas deferens in vivo: absence of the postjunctional component.
The effects of denervation and cocaine on the responsiveness of the guinea-pig vas deferens to noradrenaline (NA) were studied. The magnitude of the denervation supersensitivity differed in vivo and in vitro. Cocaine-induced supersensitivity to NA was similar in vivo and in vitro. Only denervation increased the maximum response in experiments in vitro. It is suggested that in the guinea-pig vas deferens the postjunctional component of denervation supersensitivity to NA could result from the experimental conditions involving the isolation procedure.
D000818:Animals; D003042:Cocaine / Q000494:pharmacology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009121:Muscle Denervation; D009130:Muscle, Smooth / Q000187:drug effects*; D009469:Neuromuscular Junction / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology*; D014649:Vas Deferens / Q000187:drug effects / Q000294:innervation
D003042:Cocaine; D009638:Norepinephrine