[Prophylaxis of peritoneal adhesions with streptokinase and streptodornase (Varidase). An experimental study in animals (author's transl)].
Animal experiments on 40 Wistar rats show that intraperitoneal application of Varidase can reduce or prevent the formation of adhesions after intra-abdominal interventions. This effect is interpreted as the sequel to a local increase in fibrinolytic activity which leads to the accelerated breakdown of fibrinous pseudo-membranes. The healing of intestinal sutures appears not to be impaired by Varidase.
D000818:Animals; D003238:Connective Tissue / Q000473:pathology; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects; D007415:Intestinal Obstruction / Q000209:etiology; D007422:Intestines / Q000473:pathology; D007813:Laparotomy / Q000009:adverse effects; D008297:Male; D010532:Peritoneal Diseases / Q000517:prevention & control*; D051381:Rats; D013299:Streptodornase and Streptokinase / Q000494:pharmacology / Q000627:therapeutic use*; D000267:Tissue Adhesions; D014945:Wound Healing / Q000187:drug effects
D013299:Streptodornase and Streptokinase
Zur Prophylaxe peritonealer Verwachsungen mit Streptokinase und Streptodornase (Vardiase). Eine tierexperimentelle Studie