title: Frequency of IgA deficiency in blood donors and Rh negative women in Iceland.
abstract: Sera from 6,842 individuals were tested for IgA deficiency, using double and radial immunodiffusion. Sera containing less than 1 mg/100 ml of IgA were classified as deficient. The frequency of selective IgA deficiency among 4,799 blood donors investigated was 1:533, but 1:340 among 1,017 Rh negative women screened and 1:485 for both groups combined. One of the nine IgA deficient blood donors detected belonged to a 1st cousin marriage family previously investigated, in which the mother also was deficient in IgA. One IgA deficient recipient was found among 704 hospital patients screened for this abnormality.
mesh_terms: D000293:Adolescent; D000328:Adult; D001782:Blood Donors; D003241:Consanguinity; D004406:Dysgammaglobulinemia / Q000453:epidemiology* / Q000235:genetics; D005260:Female; D006801:Humans; D007055:Iceland; D005779:Immunodiffusion; D007070:Immunoglobulin A / Q000032:analysis; D007153:Immunologic Deficiency Syndromes / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D012204:Rh-Hr Blood-Group System
chemical_list: D007070:Immunoglobulin A; D012204:Rh-Hr Blood-Group System