Effects of a plasticizer leached from polyvinyl chloride on the subhuman primate: a consequence of chronic transfusion therapy.
The effects of di-2-ethylhexyl phthalate (DEHP) on hepatic function and histology were evaluated in the rhesus monkey undergoing chronic transfusion. DEHP was solubilized as a result of leaching by platelets or plasma stored in polyvinyl chloride (PVC) blood bags. The average cumulative amount of DEHP infused in 1 year was 69.3 mg., or 21.3 mg./kg. Comparable amounts of DEHP are received by patients who undergo chronic transfusions with whole blood, packed cells, platelets, and plasma in the same time period. Four of the seven PVC-transfused monkeys had abnormal 99mTc liver-spleen scan ratios, four of the seven demonstrated abnormal BSP clearance, and six of the seven had abnormal liver histopathology upon completion of transfusion therapy. These findings persisted in a majority of the monkeys throughout the follow-up period. DEHP persisted in the tissues for up to 14 months after transfusion. The nontransfused monkeys and those transfused with platelets processed in polyethylene containers were normal.
D000818:Animals; D001792:Blood Platelets; D001793:Blood Preservation / Q000295:instrumentation*; D004051:Diethylhexyl Phthalate / Q000633:toxicity*; D000882:Haplorhini; D006801:Humans; D008099:Liver / Q000187:drug effects*; D008253:Macaca mulatta; D010795:Phthalic Acids / Q000633:toxicity*; D010968:Plasticizers / Q000633:toxicity*; D011095:Polyethylenes / Q000633:toxicity; D011143:Polyvinyl Chloride / Q000633:toxicity; D013997:Time Factors; D065227:Transfusion Reaction
D010795:Phthalic Acids; D010968:Plasticizers; D011095:Polyethylenes; D011143:Polyvinyl Chloride; D004051:Diethylhexyl Phthalate