The effect of delta 9-tetrahydrocannabinol, cannabidiol, and cannabinol on the anaesthesia induced by various anaesthetic agents in mice.
delta 9-Tetrahydrocannabinol (2.5-80.0 mg/kg) significantly prolonged the anaesthesia induced by ketamine, pentobarbitone, thiopentone, propanidid, and Alfathesin in a dose-dependent manner. Cannabinol and cannabidiol (both 5.0-80.0 mg/kg) were essentially inactive, except that cannabidiol prolonged pentobarbitone-induced anaesthesia. The interaction of delta 9-tetrahydrocannabinol with the anaesthetic agents was postulated to be due to a centrally mediated action, whereas the effect of cannabidiol on pentobarbitone-induced anaesthesia probably depended on a metabolic interaction. The interaction between the cannabinoids in influencing anaesthesia induced by the above agents was examined, and the interactions were found to be complex.
D000530:Alfaxalone Alfadolone Mixture / Q000037:antagonists & inhibitors; D000777:Anesthetics / Q000037:antagonists & inhibitors*; D000818:Animals; D002186:Cannabinoids / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D013759:Dronabinol / Q000494:pharmacology; D004347:Drug Interactions; D005260:Female; D007649:Ketamine / Q000037:antagonists & inhibitors; D051379:Mice; D010424:Pentobarbital / Q000037:antagonists & inhibitors; D011410:Propanidid / Q000037:antagonists & inhibitors; D013874:Thiopental / Q000037:antagonists & inhibitors
D000777:Anesthetics; D002186:Cannabinoids; D007649:Ketamine; D013759:Dronabinol; D000530:Alfaxalone Alfadolone Mixture; D011410:Propanidid; D010424:Pentobarbital; D013874:Thiopental