The use of tetracyclines on the chemotherapy of experimental East Coast Fever (theileria parva infection of cattle).
In a series of experiments, groups of cattle, undergoing patent East Coast fever (ECF) reactions induced by the inoculation of tick-derived stabilates of Theileria parva infective particles, were treated by parenteral administration of 2 tetracyclines. Ten cattle were treated with n-pyrrolidinomethyl tetracycline at 15 mg/kg for 5 days, starting on the first day macroschizonts were detected in lymph node biopsy smears. Nine of these treated cattle survived ECF reactions induced by an inoculum which killed 7 of 10 untreated controls. The same tetracycline, at 10 mg/kg daily for 5 days from the first day of febrile response had no effect on the disease. Oxytetracycline was administered at 15 mg/kg daily for 5 days to 2 groups of cattle infected with ECF. All 5 cattle survived which were treated on the first day parasites were seen. Four of 5 survived in which treatment was delayed till the onset of febrile response. All 5 untreated controls in this experiment died.
D000818:Animals; D016782:Apicomplexa / Q000187:drug effects; D002417:Cattle; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D013754:Tetracyclines / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D013801:Theileriasis / Q000188:drug therapy*
D013754:Tetracyclines