[Interaction of streptidin-dependent Actinomyces streptomycini (Streptomyces griseus) mutants No. 170 and 145 with mutants having blocks at various stages of streptomycin biosynthesis].
In complementation analysis of low active streptidine dependent strains of Act. streptomycini, 170 and 145 with mutants having different blocks in biosynthesis of streptomycin it was found that these strains were the donors of some thermostable substances and could reduce the biosynthesis of streptomycin in the mutants having impairements in biosynthesis of streptidine and streptobiosamine, as well as in a number of strains with unknown blocks. It is supposed that the substances produced by mutants 170 and 145 were intermediate products in streptomycin biosynthesis.
D003511:Cyclohexanols / Q000096:biosynthesis; D005816:Genetic Complementation Test; D006146:Guanidines / Q000096:biosynthesis*; D006595:Hexosamines; D008968:Molecular Conformation; D009154:Mutation / Q000187:drug effects*; D013305:Streptomyces griseus / Q000235:genetics / Q000378:metabolism*; D013307:Streptomycin / Q000037:antagonists & inhibitors* / Q000096:biosynthesis
D003511:Cyclohexanols; D006146:Guanidines; D006595:Hexosamines; C005733:streptidine; D013307:Streptomycin
Izuchenie vzaimodeĭstviia streptidin-zavisimykh mutantov Actinomyces streptomycini (Streptomyces griseus) No. 170 i 145 s mutantami, imeiushchimi bloki na razlichnykh étapakh biosinteza streptomitsina.