Islet cell transplantation in treatment of diabetes.
Transplantation of isolated islets in volunteer patients with functioning renal allografts reduced their insulin requirements for up to 18 months. These trials were based on experiments with rats with induced diabetes in which plasma glucose levels and glucosuria were decreased, and retinal and renal complications prevented or reversed. The approach may make possible correction of the carbohydrate metabolism defect.
D000328:Adult; D000818:Animals; D003920:Diabetes Mellitus / Q000601:surgery*; D003921:Diabetes Mellitus, Experimental / Q000601:surgery; D003928:Diabetic Nephropathies / Q000601:surgery; D005069:Evaluation Studies as Topic; D005260:Female; D006650:Histocompatibility Testing; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000378:metabolism; D016381:Islets of Langerhans Transplantation; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D051381:Rats; D014184:Transplantation, Homologous
D007328:Insulin