title: Clinical studies of the interaction between tolmetin and glibenclamide.
abstract: Forty patients with diabetes mellitus and rheumatic disorders (rheumatoid arthritis, osteoarthritis, soft-tissue rheumatism) were included in a double-blind trial with the purpose of investigating whether the concomitant administration of tolmetin and glibenclamide leads to an interaction. No significant alterations of blood and urine glucose values could be found in comparison to placebo. Therefore it can be assumed that there is no interaction between these two substances.
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000188:drug therapy*; D004347:Drug Interactions; D005260:Female; D005905:Glyburide / Q000627:therapeutic use*; D006029:Glycosuria / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D011758:Pyrroles / Q000627:therapeutic use*; D012216:Rheumatic Diseases / Q000150:complications / Q000188:drug therapy*; D013997:Time Factors; D014046:Tolmetin / Q000627:therapeutic use*
chemical_list: D001786:Blood Glucose; D011758:Pyrroles; D014046:Tolmetin; D005905:Glyburide