title: Optic atrophy after irrigation of the lacrimal ducts with chloramphenicol.
abstract: A case is presented of permanent visual loss and optic atrophy following irrigation of the lower canaliculus after probing, with a 20% solution of chloramphenicol. A false passage had apparently been created allowing the solution to gain access to the orbital tissues. The ensuing orbital edema probably caused a central retinal artery occlusion. This is a previously unreported complication of a common ophthalmologic procedure.
mesh_terms: D000328:Adult; D001157:Arterial Occlusive Diseases / Q000150:complications / Q000209:etiology; D001766:Blindness / Q000139:chemically induced*; D002701:Chloramphenicol / Q000009:adverse effects*; D004487:Edema / Q000139:chemically induced / Q000150:complications; D005260:Female; D006801:Humans; D007767:Lacrimal Duct Obstruction / Q000188:drug therapy*; D009883:Ophthalmic Solutions; D009896:Optic Atrophy / Q000139:chemically induced*; D009915:Orbit; D012161:Retinal Artery; D007507:Therapeutic Irrigation / Q000009:adverse effects*
chemical_list: D009883:Ophthalmic Solutions; D002701:Chloramphenicol