[Effect of DMBA and benz (alpha) anthracene on the biogenic amine level in the rat brain].
Thirty minutes after the administration of DMBA (5 mg i. v.) to rats the level of norepinephrine, dopamine, serotonine (5-HT) and 5-IIIAA in the hypothalamus was decreased, while monoamines levels in the brain stem and hemispheres was unchanged. After benz(a) anthracene (5 mg i.v.) treatment the level of 5-HT in rat hypothalamus was decreased, but catecholamines and 5-HIAA levels were not changed. Pretreatment with L-DOPA abolished the elevation of the threshold of hypothalamic sensitivity to estrogen suppression, induced by 20-methylcholanthrene in rats, and alpha-methyl-DOPA enhanced. It is suggested that the central (hypothalamic) mechanisms participate in the release of the carcinogenic effect of polycylic hydrocarbons in rats.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000494:pharmacology*; D000818:Animals; D001551:Benz(a)Anthracenes / Q000494:pharmacology*; D001679:Biogenic Amines / Q000378:metabolism*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002369:Castration; D004054:Diethylstilbestrol / Q000494:pharmacology; D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives / Q000494:pharmacology; D004361:Drug Tolerance; D005260:Female; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism; D007980:Levodopa / Q000494:pharmacology; D008297:Male; D008748:Methylcholanthrene / Q000494:pharmacology; D051381:Rats; D013997:Time Factors
D001551:Benz(a)Anthracenes; D001679:Biogenic Amines; D007980:Levodopa; D008748:Methylcholanthrene; D015127:9,10-Dimethyl-1,2-benzanthracene; D004295:Dihydroxyphenylalanine; D004054:Diethylstilbestrol
Vliianie DMBA i benz(al'fa)antratsena na uroven' biogennykh aminov v golovnom mozge krys.