title: [Current developments on the physiology of the cardiac atrial pacemaker an excitation conduction of the left atrium].
abstract: According to recent developments the atrial pacemaker area and the right atrium show a peculiar morpho-functional organization, i.e.: 1) The pacemaker area is formed of clusters of cells containing relatively few myofibrils and showing embryologic characteristics. Such cells are known as nodal cells and between these and the atrial muscles are in general situated transitional cells. Each cluster is separated from the other by collagenous boundaries. The resistance of the membranes to the current flow seems to be relatively low between the cells of the same cluster but the collagenous boundaries are, according to TRAUTWEIN e UCHIZONO (1963), very poor conductors. The pacemaker activity seems to originate inside the various clusters. 2) The functional relationships between the sinoatrial node and the atrioventricular node as well as the interatrial relationship would take place through preferential pathways. These pathways corresponding approximately to the tracts described by JAMES (1966) (anterior, posterior and middle internodal tracts) and to the interatrial or Bachmann bundle, seems to show a higher velocity conduction. In general the fibres of which the tracts are composed are neither morphologically nor functionally isolated from the atrial muscle. The functional consequences of the above mentioned nodal and atrial organization seems to be: a) The possible conditioning of the pacemaker functions by the various clusters activity i.e. the dominance of one cluster over another. b) The shifting of the pacemaker activity from one cluster to anothr due to the arrival of nervous stimuli or chemical substances, etc. According to some Authors as a consequence of the shift the pacemaker area can sometimes move out side the nodal tissue and settle inside an area belonging to the internodal pathways. c) Another consequence of the shift can be the different involvement of the conducting pathways which can lead to a change in the dynamics of the atrial invasion by the excitement.
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001283:Atrioventricular Node / Q000166:cytology* / Q000502:physiology; D003599:Cytoskeleton / Q000648:ultrastructure; D004285:Dogs; D006321:Heart / Q000294:innervation / Q000502:physiology; D006325:Heart Atria / Q000294:innervation; D006329:Heart Conduction System / Q000033:anatomy & histology / Q000166:cytology* / Q000502:physiology*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008564:Membrane Potentials / Q000187:drug effects; D008929:Mitochondria, Heart / Q000648:ultrastructure; D009638:Norepinephrine / Q000494:pharmacology; D011817:Rabbits; D051381:Rats
chemical_list: D000109:Acetylcholine; D009638:Norepinephrine
vernacular_title: Aggiornamenti sulla fisiologia del "pacemaker" atriale cardiaco e sulla conduzione dell'eccitamento nell'atrio destro.