Inhibition of tumor growth by the peptidoglycan from Bacillus megaterium.
When injected in admixture with tumor cells, the peptidoglycan extracted from Bacillus megaterium inhibited the growth of a chemically induced fibrosarcoma in syngeneic rats. In some instances, the tumor growth was totally suppressed. Animals rejecting mixed inocula exhibited a tumor-specific immunity. Peptidoglycan was not cytotoxic for tumor cells; it rendered macrophages nonspecifically cytotoxic.
D000818:Animals; D001410:Bacillus megaterium / Q000276:immunology*; D002470:Cell Survival / Q000187:drug effects; D005260:Female; D005354:Fibrosarcoma / Q000188:drug therapy; D007109:Immunity / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects; D008297:Male; D010457:Peptidoglycan / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012513:Sarcoma, Experimental / Q000188:drug therapy* / Q000276:immunology
D010457:Peptidoglycan