title: Relative positions of chromosome 1 loci Fy, PGM1, Sc, UMPK, Rh, PGD and ENO1 in man.
abstract: Ongoing linkage studies of red cell antigens and enzymes in many families along with concentration on a large Mennonite kindred segregating for Sc have resulted in lods, recombinant: nonrecombinant counts and multi-point information which support an order with approximate recombination fractions as measured in the male as follows: Fy--.25--PGM1--.20--Sc--less than .05--UMPK--.15--Rh--.20--PGD, with ENO1 close to PGD. The insertion of Sc and UMPK between PGM1 and Rh allows the recognition of double crossing-over between the latter pair; indications are that this is not a rare event in the female. In the male no evidence of double crossing-over was found in the similar distances PGM1--Rh and Sc--PGD in 13 and 19 opportunities respectively.
mesh_terms: D001789:Blood Group Antigens; D002874:Chromosome Mapping; D002900:Chromosomes, Human, 1-3; D004375:Duffy Blood-Group System; D005260:Female; D005796:Genes; D006801:Humans; D008297:Male; D010375:Pedigree; D010733:Phosphoglucomutase / Q000235:genetics; D010734:Phosphogluconate Dehydrogenase / Q000235:genetics; D010751:Phosphopyruvate Hydratase / Q000235:genetics; D012204:Rh-Hr Blood-Group System; D014541:Uridine Kinase / Q000235:genetics
chemical_list: D001789:Blood Group Antigens; D004375:Duffy Blood-Group System; D012204:Rh-Hr Blood-Group System; D010734:Phosphogluconate Dehydrogenase; D014541:Uridine Kinase; D010751:Phosphopyruvate Hydratase; D010733:Phosphoglucomutase