title: Enzymic reactions of phosphate analogs.
abstract: A variety of phosphonates (XPO32-; X = H-, CH3-, CL3C-, CH3CH2-, and phenyl-) as well as methylarsonate have been shown to be suitable phosphate analogs for the reactions catalyzed by yeast glyceraldehyde-3-phosphate dehydrogenase and calf spleen purine nucleoside phosphorylase. The reactivity of the phosphate analogs with these two enzymes is independent of the pKa of the analog.
mesh_terms: D000818:Animals; D001149:Arsenates; D001151:Arsenic; D002417:Cattle; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000378:metabolism*; D063065:Organophosphonates; D010430:Pentosyltransferases / Q000378:metabolism*; D010710:Phosphates; D011683:Purine-Nucleoside Phosphorylase / Q000378:metabolism*; D012441:Saccharomyces cerevisiae; D013154:Spleen / Q000201:enzymology; D013329:Structure-Activity Relationship
chemical_list: D001149:Arsenates; D063065:Organophosphonates; D010710:Phosphates; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases; D010430:Pentosyltransferases; D011683:Purine-Nucleoside Phosphorylase; D001151:Arsenic