[Mechanism of increasing the effect of antineoplastic agents by hydrazine sulfate].
The results of the in vivo and in vitro experiments indicated that hydrazine sulphate is a new potent inhibitor of the biotransformation of physiologically active compounds, including those with an antitumor effect. It is suggested that hydrazine sulphate renders an inhibitory effect by retarding the access of xenobiotics to microsomal enzymes active centers metabolizing them. The retardation of antitumor compounds biotransformation effected by hydrazine sulphate in vitro enabled the explanation of the enhanced effect of cytostatics, used in combination with hydrazine sulphate in vivo. This fact seems to speak in favour of the perspective clinical application of hydrazine sulphate for potentiation of the antitumor effect of cytostatics.
D000818:Animals; D001711:Biotransformation / Q000187:drug effects; D004357:Drug Synergism; D006834:Hydrazines / Q000494:pharmacology*; D066298:In Vitro Techniques; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000188:drug therapy / Q000473:pathology; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000473:pathology; D051381:Rats; D013852:Thiotepa / Q000494:pharmacology* / Q000627:therapeutic use
D006834:Hydrazines; D013852:Thiotepa
O mekhanizme usileniia deĭstviia protivoopukholevykh veshchestv gidrazinsul'fatom.