Chemistry and pharmacology of homologs of 6-acetyl-and 3,6-diacetylmorphine.
3,6-Diformyl- and 3,6-dipropanoylmorphine and 6-formyl- and 6-propanoylmorphine were prepared to obtain longer acting, heroin-like compounds. The 6-acylated compounds were more potent than heroin subcutaneously and were orally effective, and their duration of action was at least two to three times greater than that of heroin in monkey species.
D000107:Acetylation; D000700:Analgesics; D000818:Animals; D000882:Haplorhini; D003932:Heroin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D051379:Mice; D009021:Morphine Dependence / Q000503:physiopathology*; D009022:Morphine Derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D013997:Time Factors
D000700:Analgesics; D009022:Morphine Derivatives; D003932:Heroin