[Combined action of antiblastoma preparations on lysozyme activity in animal organs].
The lysozyme activity in the spleen, kidneys and lungs of the mice treated with neocid, sarcolysine or Tio-Fef in therapeutic doses increased or remained at the control level by the 5th or 10th day after the drug administration. The use of sarcolysine per se or in combination with neocid increased the activity of lysozyme in the spleen, kidneys and lungs during the whole period of the experiment as compared to the control. The values of the lysozyme activity in the spleen and lungs of the animals treated with neocid in combination with sarcolysine were higher for 5 days, and in all organs examined were higher by the 10the day as compared to the animals treated with neocid alone. Increased lysozyme activity in the spleen, kidneys and lungs was observed under the effect of neocid in combination with sarcolysine as compared to the lysozyme activity in mice treated with sarcolysine per se (assay on the 10th day). Decreased lysozyme activity was determined in the spleen, kidneys and lungs by the 5th day and in the kidneys by the 10th day in the mice treated with sarcolysine in combination with Tio-Tel and in the spleen and lungs by the 5th and 10th days in the animals treated with neocid in combination with sarcolysine or Tio-Tef as compared to the animals treated with sarcolysine. The lysozyme activity in the kidneys under the effect of sarcolysine combination with Tio-Tef was lower by the 5th days and higher by the 10th day as compared to that under the effect of Tio-Tef.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D003634:DDT / Q000494:pharmacology; D004347:Drug Interactions; D004789:Enzyme Activation / Q000187:drug effects; D007113:Immunity, Innate / Q000187:drug effects; D007668:Kidney / Q000201:enzymology; D008168:Lung / Q000201:enzymology; D008558:Melphalan / Q000494:pharmacology*; D051379:Mice; D009113:Muramidase / Q000378:metabolism*; D013154:Spleen / Q000201:enzymology; D013852:Thiotepa / Q000494:pharmacology*; D013997:Time Factors
D000903:Antibiotics, Antineoplastic; D013852:Thiotepa; D003634:DDT; D009113:Muramidase; D008558:Melphalan
Kombinirovannoe deĭstvie antiblastomykh preparatov na aktivnost' lizotsima v organakh zhivotnykh.