[Comparative immunochemical study of the hemagglutinins of Cl. botulinum A and B].
The authors demonstrated an incomplete indentity of Cl. botulinum hemagglutinins of types A and B in the double diffusion reaction in agar gel, and their difference by electrophoretic mobility. Some differences in the interaction of hemagglutinins A and B with human erythrocytes were found by the hemagglutination inhibition method; apparently, of the principal significance in the relization of the reaction of human erythrocyte hemagglutination with hemagglutinins of Cl. botulinum, types A and B, was the OH-group position in the C4 galactose of the mucopolysaccharides of the erythrocyte cell wall. Apart from C4, apparently, for hemagglutinin of types A of significance was the reactive capacity of C1 and C2 galactose atoms, whereas for hemagglutinin of type B--free OH-group in C2 galactose atom.
D000373:Agglutinins / Q000302:isolation & purification*; D002241:Carbohydrates / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D003014:Clostridium botulinum / Q000276:immunology*; D003864:Depression, Chemical; D006384:Hemagglutination / Q000187:drug effects; D006386:Hemagglutination Tests; D006388:Hemagglutinins / Q000302:isolation & purification*; D005779:Immunodiffusion; D007122:Immunoelectrophoresis
D000373:Agglutinins; D002241:Carbohydrates; D006388:Hemagglutinins
Sravnitel'noe immunokhimicheskoe izuchenie gemaggliutininov Cl. botulinum A i B