Airway mucosal permeability in the Ascaris suum-sensitive rhesus monkey.
The permeability of the airways to technetium 99m-labeled albumin was measured in Ascaris suum-sensitive rhesus monkeys. All 8 animals were skin-sensitive to Ascaris suum (AA) antigen, 4 being respiratory responders (R) and 4 nonresponders (NR) to aerosolized antigen. In the absence of antigen challenge there were no differences in the accumulation in the blood of radioactive material from the tracheobranchial tree between the R and NR animals. After a five-minute challenge with aerosolized AA, there was a threefold increase in the rate of accumulation of radioactive material in the blood over control for the R group with no effect noted in the NR group. Gel filtration data indicated that the radioactivity in the blood most likely represented low molecular weight albumin fragments, resulting from spontaneous degradation of Tc-albumin, that crossed the mucosa and partially bound to circulating albumin. It is concluded that hyperpermeability of the airway mucosa probably is not a factor that contributes to the selective responsiveness of the R group to aerosolized antigen, and that airway permeability is increased consequent to the allergic reaction mediating acute bronchoconstriction.
D000336:Aerosols; D000818:Animals; D000941:Antigens; D001200:Ascaris; D002463:Cell Membrane Permeability; D004195:Disease Models, Animal; D005919:Glomerular Filtration Rate; D000882:Haplorhini; D006967:Hypersensitivity / Q000276:immunology; D007328:Insulin / Q000097:blood; D008251:Macaca; D009092:Mucous Membrane / Q000276:immunology*; D012137:Respiratory System / Q000276:immunology*; D012709:Serum Albumin / Q000378:metabolism*
D000336:Aerosols; D000941:Antigens; D007328:Insulin; D012709:Serum Albumin