Rhizopus osteomyelitis. A case report and review.
Mucormycosis osteomyelitis has previously been described exclusively in association with contiguous infections of rhinocerebral mucormycosis. In a patient with corticosteroid-dependent neutropenia and anemia osteomyelitis of the femur developed caused by the Mucoraceae Rhizopus. Although a primary focus was not identified, we believe this infection was hematogenous in origin. Mitogen stimulation to phytohemagglutinin (PHA) of the patient's lymphocytes revealed depressed cellullar immunity; however, there was specific response to Rhizopus extract. Treatment with systemic amphotericin B prevented further progression of the infection. A review of mucormycosis osteomyelitis is presented.
D000293:Adolescent; D002648:Child; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D009091:Mucormycosis / Q000188:drug therapy / Q000276:immunology; D010019:Osteomyelitis / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D012233:Rhizopus