Inhibition of prostaglandin synthesis by indoprofen.
Many non-steroidal anti-inflammatory, analgesic drugs appear to produce their effects by inhibiting prostaglandin synthesis. These investigations were undertaken to determine whether a new anti-inflammatory compound, indoprofen, inhibited prostaglandin synthesis in vitro when present in incubation medium or following systemic administration. The results indicated that indoprofen effectively inhibited prostaglandin synthesis in kidney and uterus. Indoprofen was equally effective as indomethacin and aspirin in inhibiting prostaglandin synthesis. The relative potency of the drug was intermediate between indomethacin and aspirin.
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D016861:Cyclooxygenase Inhibitors; D003864:Depression, Chemical; D005260:Female; D066298:In Vitro Techniques; D007211:Indoles / Q000494:pharmacology; D007679:Kidney Medulla / Q000187:drug effects / Q000378:metabolism; D010666:Phenylpropionates / Q000494:pharmacology*; D011458:Prostaglandins E / Q000096:biosynthesis*; D051381:Rats; D014599:Uterus / Q000187:drug effects / Q000378:metabolism
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D007211:Indoles; D010666:Phenylpropionates; D011458:Prostaglandins E