Failure of prolonged hypocapnia, hypothermia, or hypertension to favorably alter acute stroke in primates.
The effects of induced hypocapnia, hypothermia, and hypertension were surveyed in a primate model of acute stroke during and following a 48-hour period of intensive care. The results were compared to a group of nine control animals previously studied. Hypocapnia (PaCO2=25 torr) was examined in five animals and did not appear to alter the expected mortality, degree of neurological deficit, or frequency of infarction. There was, however, a suggestion that the size of infarction may be reduced. Hypothermia (29 degrees C) in five animals had a detrimental effect in that no animals survived following the intensive care period and all had infarction with massive edema. We speculate that hypothermia caused a sufficient increase in blood viscosity as to compromise collateral flow, thereby accounting for this detrimental effect. Induced hypertension (to 20% above control levels) was abandoned after three animals because of severe systemic effects (cardiac failure and pulmonary edema) resulting in death during the period of intensive care.
D000208:Acute Disease; D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001809:Blood Viscosity; D002245:Carbon Dioxide / Q000097:blood*; D002561:Cerebrovascular Disorders / Q000097:blood / Q000150:complications / Q000628:therapy*; D004195:Disease Models, Animal; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D000882:Haplorhini; D006973:Hypertension / Q000139:chemically induced*; D007036:Hypothermia, Induced; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology
D000804:Angiotensin II; D002245:Carbon Dioxide; D010656:Phenylephrine; D009638:Norepinephrine; D004837:Epinephrine