title: Bicyclic pyrazolines, potential central nervous system depressants and antiinflammatory agents.
abstract: The synthesis and CNS activity of a series of 34 substituted bicyclic pyrazolines are described. Ten of these compounds were also screened for antiinflammatory activity. One of the compounds (15) exhibited significant antiinflammatory activity in the carrageenan-induced edema test.
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis*; D002351:Carrageenan; D002492:Central Nervous System Depressants / Q000138:chemical synthesis*; D004487:Edema / Q000139:chemically induced / Q000503:physiopathology; D005260:Female; D008297:Male; D051379:Mice; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced; D013329:Structure-Activity Relationship
chemical_list: D000893:Anti-Inflammatory Agents; D002492:Central Nervous System Depressants; D011720:Pyrazoles; D002351:Carrageenan