Endotoxin-challenged monkeys and rats.
Studies in our laboratory with both the monkey and the rat showed that, after three hours of endotoxemia, there was a significant decrease in the number of circulating platelets, total hemolytic complement (CH 50 units), and blood serotonin (5-HT) levels. Administration of dexamethasone sodium phosphate in the clinical dose range at the time of endotoxin challenge significantly attenuated the decrease in blood 5-HT levels when compared to the untreated groups in both the monkey and the rat experiments. In the monkey, CH 50 units remained at a higher level when dexamethasone was administered; however, the difference between the treated and untreated groups was not statistically significant. The number of circulating white blood cells and platelets did not appear to be significantly altered by corticosteroid treatment. It is suggested that glucocorticoids may interfere with lipopolysaccharide-induced alterations in complement components or factors regulating hemostasis that influence platelet 5-HT release.
D000818:Animals; D001792:Blood Platelets / Q000187:drug effects; D003165:Complement System Proteins / Q000032:analysis; D003907:Dexamethasone / Q000494:pharmacology*; D004347:Drug Interactions; D006088:Gram-Negative Aerobic Bacteria / Q000187:drug effects*; D000882:Haplorhini; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007958:Leukocyte Count; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008297:Male; D051381:Rats; D012701:Serotonin / Q000097:blood*; D013997:Time Factors
D008070:Lipopolysaccharides; D012701:Serotonin; D003907:Dexamethasone; D003165:Complement System Proteins