Studies on pyrazine derivatives. Part VII. Synthesis and tuberculostatic activity of some pyrazine amidines and amidoximes.
In the reaction of 2-cyano-6-alkylaminopyrazines with sec. amines in the presence of anhyd. AlCl3 amidines 1-13 were obtained. From pyrazine-2-imidoesters, 2-cyano-pyrazines and pyrazine-2-carbothioamides and hydroxylamine, amidoximes 14-49 were easily prepared. These new compounds were, however, of little tuberculostatic activity (MIC between 31.5-2000 mug/cm3).
D000578:Amidines / Q000138:chemical synthesis / Q000494:pharmacology; D000995:Antitubercular Agents / Q000138:chemical synthesis*; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D010091:Oximes / Q000138:chemical synthesis / Q000494:pharmacology; D011719:Pyrazines / Q000138:chemical synthesis* / Q000494:pharmacology
D000578:Amidines; D000995:Antitubercular Agents; D010091:Oximes; D011719:Pyrazines