Cholelithiasis in a male rhesus monkey (Macaca mulatta) fed a cholesterol-containing diet.
In this report we describe the development of cholelithiasis in a male rhesus monkey fed a cholesterol-containing diet for 24 months. This represents the only case of cholelithiasis in this species of nonhuman primate that we have observed out of a population of over 500 rhesus monkeys fed similar cholesterol-containing diets. Associated with the appearance of gallstones was the production of bile saturated with cholesterol, and the excretion of bile with an abnormal bile acid composition.
D000818:Animals; D001646:Bile / Q000378:metabolism; D002769:Cholelithiasis / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D002784:Cholesterol / Q000378:metabolism; D002791:Cholesterol, Dietary / Q000009:adverse effects*; D000882:Haplorhini; D006937:Hypercholesterolemia / Q000209:etiology / Q000662:veterinary; D008251:Macaca; D008253:Macaca mulatta; D008297:Male; D008992:Monkey Diseases / Q000209:etiology* / Q000473:pathology
D002791:Cholesterol, Dietary; D002784:Cholesterol