title: Anti-inflammatory and PG inhibitory effects of phenacetin and acetaminophen.
abstract: Although acetaminophen and phenacetin do not inhibit PG synthesis when added directly to isolated rat platelets and when given orally, both drugs inhibit carrageenan-induced hindpaw edema--a widely used inflammatory assay method. It does not appear that the anti-inflammatory effects of these non-steroidal drugs (unlike other well-known non-steroidal drugs) can be explained on the basis of PG-synthetase inhibition.
mesh_terms: D000082:Acetaminophen / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents; D001241:Aspirin / Q000494:pharmacology; D001792:Blood Platelets / Q000378:metabolism; D002351:Carrageenan / Q000037:antagonists & inhibitors; D016861:Cyclooxygenase Inhibitors; D007249:Inflammation / Q000139:chemically induced; D008297:Male; D010615:Phenacetin / Q000494:pharmacology*; D011448:Prostaglandin Antagonists; D011453:Prostaglandins / Q000096:biosynthesis; D051381:Rats
chemical_list: D000893:Anti-Inflammatory Agents; D016861:Cyclooxygenase Inhibitors; D011448:Prostaglandin Antagonists; D011453:Prostaglandins; D000082:Acetaminophen; D002351:Carrageenan; D010615:Phenacetin; D001241:Aspirin