The influence of pre- and perinatal malnutrition on sulphated glycosaminoglycans in rat brain.
Pre- and perinatal malnutrition of rats was achieved by restricting the intake of food to 50% during lactation and pregnancy. After 40 days offspring were injected with Na2(35)SO4 before being killed. Lipid-free brain material was now hydrolysed with papain and glycosaminoglycan samples chromatographed on DEAE-cellulose. After chemical characterisation studies 2.5 times more chondroitin sulphate was detected in tissue from the ill-fed animals. Little variation in heparan sulphate content was observed. The marked increase in the concentration as well as qualitative changes in sulphated glycosaminoglycans during pre- and perinatal malnutrition as compared to the normal are discussed in relation to brain maturation.
D000818:Animals; D001921:Brain / Q000196:embryology / Q000254:growth & development / Q000378:metabolism*; D002809:Chondroitin Sulfates / Q000378:metabolism; D005260:Female; D006025:Glycosaminoglycans / Q000378:metabolism*; D006497:Heparan Sulfate / Q000378:metabolism; D009748:Nutrition Disorders / Q000378:metabolism*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism*; D051381:Rats
D002809:Chondroitin Sulfates; D006025:Glycosaminoglycans; D006497:Heparan Sulfate