Free amino acids in motor cortex of amyotrophic lateral sclerosis.
Free amino acids were estimated quantitatively in the motor cortex from 3 patients with amyotrophic lateral sclerosis (ALS) and 11 control subjects. Among 7 amino acids which showed statistically significant changes, taurine was the only one which was increased constantly and most markedly in the motor cortex of all the 3 ALS cases. It was suggested that the metabolism of sulfur amino acids might be affected in comparatively early stages of ALS.
D000328:Adult; D000368:Aged; D000596:Amino Acids / Q000378:metabolism*; D000690:Amyotrophic Lateral Sclerosis / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000166:cytology / Q000378:metabolism*; D013654:Taurine / Q000378:metabolism
D000596:Amino Acids; D013654:Taurine