title: Soluble artifical tear inserts.
abstract: This article reports a new concept in the treatment of tear film abnormalities. Solubilization of an artifical tear insert provides a continuous flow of polymer into the tear film in place of intermittent drop therapy. The physiochemical properties of succinylated collagen were studied in vitro and compared favorably with presently available tear substitutes. The use of this polymer as a solid solubilizable insert was evaluated in normal patients. It was found to be comfortable, resulted in no blurring of vision, and prolonged the tear film breakup time.
mesh_terms: D002482:Cellulose / Q000031:analogs & derivatives / Q000627:therapeutic use; D003094:Collagen / Q000627:therapeutic use*; D004338:Drug Combinations; D004492:Edetic Acid / Q000627:therapeutic use; D005128:Eye Diseases / Q000628:therapy*; D006801:Humans; D008747:Methylcellulose / Q000627:therapeutic use; D009883:Ophthalmic Solutions / Q000627:therapeutic use; D011108:Polymers; D011142:Polyvinyl Alcohol / Q000627:therapeutic use; D011205:Povidone / Q000627:therapeutic use; D012995:Solubility; D013666:Tears; D013849:Thimerosal / Q000627:therapeutic use; D013997:Time Factors; D014783:Viscosity
chemical_list: D004338:Drug Combinations; D009883:Ophthalmic Solutions; D011108:Polymers; D013849:Thimerosal; D011142:Polyvinyl Alcohol; D002482:Cellulose; D008747:Methylcellulose; D003094:Collagen; D004492:Edetic Acid; D011205:Povidone