Antitumor activity of a Brucella abortus preparation.
Mice injected intraperitoneally with sarcoma-180 cells develop ascites and eventually die. Intraperitoneal injection of a nonviable, aqueous... ether-extracted Brucella abortus preparation (BRU-PEL) as early as 7 days before or as late as 7 days after injection of tumor cells significantly inhibited development of ascites and protected against death. BRU-PEL was not effective if injected after ascites was grossly apparent. BRU-PEL was significantly more active than a Corynebacterium parvum preparation administered in the same way.
D000818:Animals; D000970:Antineoplastic Agents; D002003:Brucella abortus / Q000276:immunology*; D005260:Female; D051379:Mice; D011425:Propionibacterium acnes / Q000276:immunology; D012510:Sarcoma 180 / Q000517:prevention & control*; D014020:Tissue Extracts
D000970:Antineoplastic Agents; D014020:Tissue Extracts