title: [Search for translocation heterozygous female mice among the progeny from males subjected to chemical mutagen (thioTHEPA) exposure].
abstract: C57Bl/6Y male mice were intraperitoneally injected with thioTEPA at a dose of 1.25 mg/kg. The male mice were crossed with F1CD hybrid females during the second week after the treatment. 122 females F1 obtained from this cross were examined. The embryonic lethality was studied and preparations of meiotic metaphases I in oocytes were found among the progeny F1. Among F1 females 41 (33.6%) "semisterile" and sterile ones were found. Translocations were cytogenetically confirmed only in 8 females out of 38 investigated.
mesh_terms: D000818:Animals; D002869:Chromosome Aberrations; D020964:Embryo Loss / Q000139:chemically induced; D005260:Female; D006579:Heterozygote; D006824:Hybridization, Genetic / Q000187:drug effects; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009153:Mutagens; D009865:Oocytes / Q000187:drug effects; D011247:Pregnancy; D012737:Sex Factors; D013094:Spermatozoa / Q000187:drug effects; D013852:Thiotepa / Q000494:pharmacology*; D014178:Translocation, Genetic / Q000187:drug effects*
chemical_list: D009153:Mutagens; D013852:Thiotepa
vernacular_title: Poisk geterozigotnykh po translokatsiiam samok mysheĭ sredi potomkov ot samtsov, podvergnutykh vozdeĭstviiu khimicheskogo mutagena (tioTEF).