Elevated prostaglandin production in cultured cells from a patient with fibrodysplasia ossificans progressiva.
Prostaglandin E production was measured in cells cultured from both a fibromatoid lesion and a normal area of skin in a patient with fibrodysplasia ossificans progressiva. The synthesis of prostaglandin E-like material (iPGE) was ten- to twenty-fold greater in cells cultured from the patient's fibromatoid lesion than in fibroblasts obtained from her normal skin. Addition of indomethacin in vitro resulted in a greater than 95% reduction of iPGE production in both cell cultures. These observations appear to warrant further investigation in additional patients, with this disease.
D002478:Cells, Cultured; D012968:Etidronic Acid / Q000494:pharmacology; D005260:Female; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology; D007223:Infant; D009221:Myositis Ossificans / Q000378:metabolism*; D011458:Prostaglandins E / Q000096:biosynthesis* / Q000378:metabolism; D012636:Secretory Rate / Q000187:drug effects
D011458:Prostaglandins E; D012968:Etidronic Acid; D007213:Indomethacin