Carbonic anhydrase isoenzyme B in erythrocytes of anemic and non-anemic uremic subjects.
A specific and quantitative immunological method for determination of human erythrocyte carbonic anhydrase isoenzyme B has been used to determine the contents of this enzyme in the erythrocytes from healthy persons and anemic and non-anemic subjects with renal insufficiency. The investigations have shown significant increase of carbonic anhydrase type B in the erythrocytes of patients with renal failure. The erythrocytes of anemic uremic patients have a significantly higher content of erythrocyte carbonic anhydrase isoenzyme B than the erythrocytes of non-anemic uremic subjects. Significant correlations were found between human erythrocyte carbonic anhydrase type B and hemoglobin and between it and plasma bicarbonate. No correlation was found between human erythrocyte carbonic anhydrase and plasma creatinine or creatinine clearance and serum zinc.
D000138:Acidosis / Q000097:blood; D000328:Adult; D000368:Aged; D000740:Anemia / Q000150:complications / Q000201:enzymology*; D002256:Carbonic Anhydrases / Q000097:blood*; D003404:Creatinine / Q000097:blood / Q000378:metabolism; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007527:Isoenzymes / Q000097:blood*; D008297:Male; D008875:Middle Aged; D014511:Uremia / Q000150:complications / Q000201:enzymology*; D015032:Zinc / Q000097:blood
D006454:Hemoglobins; D007527:Isoenzymes; D003404:Creatinine; D002256:Carbonic Anhydrases; D015032:Zinc