Sequence studies on the heavy chain of rabbit immunoglobulin A of different alpha-locus allotypes.
The amino acid sequence was determined of part of the variable region of heavy chain from rabbit immunoglobulin A of allotypes a1 and a3. Two corrections of the primary sequence of Aa1 gamma-chains are reported; most of the structural correlates of the alpha-locus allotypes are confirmed. The amino acid sequence of the N-terminal 20 residues of alpha-negative molecules was also determined and found to be homologous to the human VhIII subgroup. These molecules are present in a much higher proportion in the alpha-chain pool than in the gamma-chain.
D000595:Amino Acid Sequence; D000818:Animals; D001666:Binding Sites, Antibody; D007070:Immunoglobulin A; D007126:Immunoglobulin Allotypes; D007128:Immunoglobulin Fragments; D007143:Immunoglobulin Heavy Chains; D007135:Immunoglobulin Variable Region; D007137:Immunoglobulin alpha-Chains; D007142:Immunoglobulin gamma-Chains; D011817:Rabbits
D007070:Immunoglobulin A; D007126:Immunoglobulin Allotypes; D007128:Immunoglobulin Fragments; D007143:Immunoglobulin Heavy Chains; D007135:Immunoglobulin Variable Region; D007137:Immunoglobulin alpha-Chains; D007142:Immunoglobulin gamma-Chains