title: Aspects of bronchial reactivity to prostaglandins and aspirin in asthmatic patients.
abstract: The behaviour of bronchial reactivity to PGF2alpha was studied in asthmatic patients under various experimental conditions. Premedication with aminophylline, i.v., and, to a lesser extent, with DSCG afforded a partial protection, while beclomethasone dipropionate was inactive under this point of view. Diftalone, a new non-steroid anti-inflammatory agent, was well tolerated in 9 aspirin-intolerant asthmatic patients, and did not modify the bronchial response to PGF2alpha which was found to be generally lower then that of other aspirin-tolerant asthmatic patients. PGE 1-2 and DSCG prevented the bronchospasm induced by inhalation or ingestion of acetylsalicylic acid in a small group of patients. Good protection was also reached with PGE1-2 in the exercise-induced bronchospasm.
mesh_terms: D000293:Adolescent; D000328:Adult; D000336:Aerosols; D000628:Aminophylline / Q000008:administration & dosage; D001241:Aspirin / Q000009:adverse effects*; D001249:Asthma / Q000139:chemically induced* / Q000517:prevention & control; D001980:Bronchi / Q000187:drug effects*; D004205:Cromolyn Sodium / Q000008:administration & dosage; D004342:Drug Hypersensitivity / Q000209:etiology* / Q000517:prevention & control; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011292:Premedication; D011458:Prostaglandins E / Q000008:administration & dosage; D011460:Prostaglandins F / Q000008:administration & dosage / Q000009:adverse effects; D011465:Prostaglandins, Synthetic / Q000008:administration & dosage / Q000009:adverse effects*; D014213:Tretoquinol / Q000008:administration & dosage
chemical_list: D000336:Aerosols; D011458:Prostaglandins E; D011460:Prostaglandins F; D011465:Prostaglandins, Synthetic; D000628:Aminophylline; D014213:Tretoquinol; D004205:Cromolyn Sodium; D001241:Aspirin