[Sensitivity of hexokinase and glucokinase to hormonal action during hepatocarcinogenesis].
Effects of hydrocortisone and insulin on activities of hexokinase and its isoenzymes and on glucokinase activity were studied in hepatocarcinogenesis, induced in rats by diethyl nitrosamine. After administration during 7 days of hydrocortisone into normal rats the hexokinase was inactivated by 25% due to decrease in activity of the II isoenzyme. In this case activity of glucokinase was decreased by 38% in young animals and--by 23% in older animals. Insulin, administered within 2 days, caused no effect on the hexokinase activity but the glucokinase was activated by 177%. In hepatocarcinogenesis the effect of hydrocortisone on the hexokinase activity (II isoenzyme) was distinctly decreased and with development of tumors the hormone showed a negligible efficiency. Influence of insulin on the glucokinase activity in hepatocarcinogenesis was similar to the effect found in normal liver tissue.
D000818:Animals; D002273:Carcinogens; D004052:Diethylnitrosamine; D005941:Glucokinase / Q000378:metabolism*; D006593:Hexokinase / Q000378:metabolism*; D006854:Hydrocortisone / Q000494:pharmacology*; D007328:Insulin / Q000494:pharmacology*; D008099:Liver / Q000201:enzymology*; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000201:enzymology; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000201:enzymology; D051381:Rats
D002273:Carcinogens; D007328:Insulin; D004052:Diethylnitrosamine; D006593:Hexokinase; D005941:Glucokinase; D006854:Hydrocortisone
Chuvstvitel'nost' geksokinazy i gliukokinazy k gormonal'nomu vozdeĭstviiu pri gepatokantserogeneze.