Effect of oral contraceptives on folate economy--a study in female rats.
Daily administration of one tenth of a tablet of Ovulen-50 (ethinodiol diacetate, 1 mg, ethinylestradiol, 50 microgram) to adult female rats resulted in an increase in the liver and kidney folate levels, increased urinary excretion of folate and a fall in serum folate while red blood cell folate levels remained unaffected. The tissue folate levels did not indicate adverse effect of OCA on folate economy of the body.
D000818:Animals; D001835:Body Weight; D003276:Contraceptives, Oral / Q000494:pharmacology*; D003280:Contraceptives, Oral, Synthetic / Q000494:pharmacology*; D004912:Erythrocytes / Q000378:metabolism; D004997:Ethinyl Estradiol / Q000494:pharmacology; D005040:Ethynodiol Diacetate / Q000494:pharmacology; D005260:Female; D005492:Folic Acid / Q000097:blood / Q000378:metabolism* / Q000652:urine; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D051381:Rats
D003276:Contraceptives, Oral; D003280:Contraceptives, Oral, Synthetic; D004997:Ethinyl Estradiol; D005040:Ethynodiol Diacetate; D005492:Folic Acid