[Elective induction in mice of solid and ascitic carcinoma of the exocrine pancreas by the repeated doses of antibodies against a lipoprotein lipase fraction].
Small doses, repeated for months of anti-esterase-lipoprotein antibodies, from several antisera raised against a crude lipoprotein-lipase from Rabbit adipose tissue (2), induce exocrine pancreatic carcinomas in mice, without any specific barrier. This seems to be the first case of a quite elective carcinogenic process of the pancreas, by an immunological mechanism, with a very high incidence, up to 100%. Such carcinomas are highly metastatic, produce a pancreatic carcinomatous ascites, and are deadly. This immunological pathogeny is discussed., more particulary on an action of immuno-complexes in an abnormal physiological environment.
D000818:Animals; D000906:Antibodies / Q000494:pharmacology*; D002471:Cell Transformation, Neoplastic; D005260:Female; D008071:Lipoprotein Lipase / Q000276:immunology*; D008297:Male; D051379:Mice; D009362:Neoplasm Metastasis; D010190:Pancreatic Neoplasms / Q000209:etiology* / Q000473:pathology
D000906:Antibodies; D008071:Lipoprotein Lipase
Induction élective du carcinome du pancréas exocinr, solide et ascitique, chez la souris, par l'action entretenue d'anticorps antifraction lipoprotéine-lipase brute hétérologue