Endogenous inhibitor of prostaglandin synthetase.
Mammalian serum and plasma contain an endogenous inhibitor of prostaglandin synthetase (EIPS). Human plasma fractions rich in EIPS show anti-inflammatory activity in vivo. In rats, glucocorticoids raise EIPS activity of plasma and serum. These findings suggest the existence of a natural mechanism of controlling prostaglandin synthesis, possibly related to corticosteroid action.
D000305:Adrenal Cortex Hormones / Q000494:pharmacology; D000403:Airway Resistance / Q000187:drug effects; D000818:Animals; D001095:Arachidonic Acids / Q000037:antagonists & inhibitors; D001169:Arthritis, Experimental / Q000201:enzymology; D001681:Biological Assay; D002417:Cattle; D016861:Cyclooxygenase Inhibitors; D004791:Enzyme Inhibitors / Q000097:blood*; D006801:Humans; D008297:Male; D011458:Prostaglandins E / Q000096:biosynthesis; D011460:Prostaglandins F / Q000096:biosynthesis; D012669:Seminal Vesicles / Q000201:enzymology
D000305:Adrenal Cortex Hormones; D001095:Arachidonic Acids; D016861:Cyclooxygenase Inhibitors; D004791:Enzyme Inhibitors; D011458:Prostaglandins E; D011460:Prostaglandins F