title: [Use of simethicone in the prevention of postoperative abdominal discomfort and gastrointestinal distension after cesarean section].
abstract: A double blind trial was performed in patients with Cesarean section in order to study the effect of Simeticon (Stuart Pharmaceutical Company, Pasadena, California) on the occurrence of subjective and objective signs of gas distress during the immediate postoperative period. The results obtained with Simeticon show a highly significant reduction of the analysed subjective complaints (nausea, vomiting, meteorism, discomfort in the stomach, abdominal pains) in relation to placebo. Peristaltic movements in patients treated with Simeticon appeared in the first two days in 100% of cases and only in 30% in the placebo group. Flatulence also appeared in all the patients receiving Simeticon, in contrast to only 20% in the placebo group. There was no difference in spontanous defecation between the groups. On the basis of the results obtained, and considering the non-toxicity of the drug, its chemical inertnees, good tolerance, and simple use, the authors consider simeticon very useful for the prevention and therapy of postoperative discomfort due to gas accumulation and gastro-intestinal distention after Cesarean section.
mesh_terms: D000005:Abdomen; D002585:Cesarean Section; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D005740:Gases; D006801:Humans; D007422:Intestines / Q000502:physiology; D010149:Postoperative Pain / Q000517:prevention & control*; D011183:Postoperative Complications / Q000517:prevention & control*; D011247:Pregnancy; D012828:Silicones / Q000627:therapeutic use*; D012841:Simethicone / Q000627:therapeutic use*
chemical_list: D005740:Gases; D012828:Silicones; D012841:Simethicone
vernacular_title: Prevencija postoperativnih abdominalnih tegoba i gastrointestinalne distenzije posle carskog reza simeticonom.