Effect of NTA and EDTA on calcium metabolism of chickens and Coturnix.
Five experiments were conducted in which various levels of nitrilotriacetic acid (NTA or its salt, Na2NTA) disodium ethylenediaminetetraacetic acid (Na2EDTA) and calcium (Ca) were fed to young chicks, young quail and adult quail. The duration of trials was from 1 to 28 days of age for chicks, 7 to 49 for young quail and 167 to 210 for adult quail. Feeding 0.71% NTA or an equimolar level of Na2NTA caused a moderate decrease in chicks weight and Na2EDTA caused a drastic decrease in body weight of chicks and adult quail. Feeding Na2EDTA caused greater mortality in chicks receiving a low Ca diet than a higher level of Ca. Plasma Ca levels were significantly increased by NTA in young quail and by Na2NTA in adult quail, in contrast, they were significantly decreased by Na2EDTA in adult quail. Dietary NTA promoted greater tibia mineralization (ash/dry matter) in growing chicks. Dietary NTA increased the deposition of zinc (Zn) and manganese (Mn) in the chicks tibia, but, it decreased magnesium (Mg). On the other hand, Na2EDTA caused a significant decrease in Zn and Fe in the chicks tibia and a significant increase in Mn. Coturnix are less sensitive than chickens in responding to dietary chelates.
D000085:Acetates / Q000494:pharmacology*; D000375:Aging; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001842:Bone and Bones / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D002645:Chickens / Q000378:metabolism*; D003370:Coturnix / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004492:Edetic Acid / Q000494:pharmacology* / Q000633:toxicity; D005260:Female; D008297:Male; D008903:Minerals / Q000378:metabolism; D009571:Nitrilotriacetic Acid / Q000494:pharmacology* / Q000633:toxicity; D011784:Quail / Q000378:metabolism*; D013045:Species Specificity
D000085:Acetates; D008903:Minerals; D004492:Edetic Acid; D009571:Nitrilotriacetic Acid; D002118:Calcium