The effect of turpentine on hamster cheek pouch mucosa: a model of epithelial hyperplasia and hyperkeratosis.
Hamster cheek pouches were painted thrice weekly with 50% v/v turpentine in liquid paraffin over periods ranging from 1 day to 16 weeks. Pouch mucosa was examined histologically for changes and measurements of epithelial thickness were made with a calibrated eyepiece micrometer. An increase in epithelial thickness was first observed 48 hrs. after a single painting and was accompanied by inflammatory changes in both epithelium and connective tissue. Maximal epithelial thickening occurred after 9 weeks of thrice weekly painting. Cheek pouches of animals left without further treatment for up to 1 year following 9 weeks painting were indistinguishable from controls. The epithelial response to treatment with turpentine is that of a reversible benign epithelial hyperplasia with hyperkeratosis.
D000818:Animals; D003238:Connective Tissue / Q000473:pathology; D006224:Cricetinae; D004848:Epithelium / Q000473:pathology; D006965:Hyperplasia; D007633:Keratins; D007642:Keratosis / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D008954:Models, Biological; D009061:Mouth Mucosa / Q000187:drug effects* / Q000473:pathology; D013280:Stomatitis / Q000139:chemically induced; D013997:Time Factors; D014425:Turpentine / Q000494:pharmacology*
D007633:Keratins; D014425:Turpentine