Hemophiliac with hemolytic anemia resulting from factor VIII concentrate.
Bilateral herniorrhaphy was successfully performed on a group AB hemophiliac with cirrhosis of the liver. Adequate hemostasis was maintained with infusions of commercial factor VIII concentrates and fresh frozen plasma. An anti-A antibody mediated hemolytic reaction occurred in the postoperative period. Hemolysis subsided after the cessation of commercial factor VIII infusions. The risk of such hemolytic reactions could be eliminated through the use of group-specific cryoprecipitated factor VIII.
D000017:ABO Blood-Group System; D000743:Anemia, Hemolytic / Q000209:etiology* / Q000276:immunology; D001787:Blood Group Incompatibility; D005169:Factor VIII / Q000009:adverse effects* / Q000276:immunology / Q000627:therapeutic use; D006467:Hemophilia A / Q000628:therapy*; D006552:Hernia, Inguinal / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged
D000017:ABO Blood-Group System; D005169:Factor VIII