Spectrophotometric analysis of binary mixtures of sulfonamides.
Different methods for analyzing binary mixtures by using 2 wavelengths are reviewed. The absorbance ratio calculated at 2 wavelengths, not including the isoabsorptive point, was a quadratic function of relative concentration. The curve-fitting process using orthogonal polynomials was applied to obtain the quadratic equation. An absorbance ratio can be used as a rapid purity index for sulfacetamide sodium in the presence of sulfanilamide. Sulfacetamide sodium has been determined in eye drop preparations.
D009883:Ophthalmic Solutions / Q000032:analysis; D013053:Spectrophotometry / Q000379:methods; D013449:Sulfonamides / Q000032:analysis*
D009883:Ophthalmic Solutions; D013449:Sulfonamides