Microbial production of vitamin B12 antimetabolites. III Compound 102804 from Bacillus cereus.
A basic compound with empirical formula C12H16N2O5 was isolated from Bacillus cereus 102804 fermentations of a soybean meal-glucose medium. The inhibitory activity of compound 102804 on growth of Gram-positive and Gram-negative bacteria growing in a chemically defined medium was reversed by vitamin B12, by L-methionine, and by D-methionine. It has no inhibitory activity for Escherichia coli (Davis 113-3) when grown in media containing L-methionine. The biosynthesis of 102804 coincides with the sporulation of the B. cereus, and the compound is not produced in the absence of sporulation.
D000963:Antimetabolites / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology; D001409:Bacillus cereus / Q000254:growth & development / Q000378:metabolism*; D001419:Bacteria / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003470:Culture Media; D008826:Microbial Sensitivity Tests; D013997:Time Factors; D014805:Vitamin B 12 / Q000037:antagonists & inhibitors*
D000963:Antimetabolites; D003470:Culture Media; D014805:Vitamin B 12