Embryopathic effect of ophthalmic EDTA.
Studies on the potential teratogenic effect of topically applied EDTA (0.1% and 3%) were undertaken because of its proven teratogenic effects when administered systemically and because of its wide use as an ophthalmic drug. Although no teratogenic effect was found for either 0.1% or 3% solution of EDTA, 3% EDTA applied topically to the eye six times a day has a significant embryopathic effect, with only 30% of the progeny remaining normal.
D000287:Administration, Topical; D000818:Animals; D004492:Edetic Acid / Q000008:administration & dosage / Q000009:adverse effects*; D004622:Embryo, Mammalian / Q000187:drug effects*; D005260:Female; D009883:Ophthalmic Solutions; D011247:Pregnancy; D011817:Rabbits; D013723:Teratogens
D009883:Ophthalmic Solutions; D013723:Teratogens; D004492:Edetic Acid