Mutagenicity of polycyclic hydrocarbons. V. Induction of sister-chromatid exchanges in vivo.
The potency of polycyclic hydrocarbons to induce SCEs in vivo was analysed. The most potent SCE-inducing compound was benzo[a]pyrene. Benzanthracene, benzo[b]fluoranthene, benzo[e]pyrene, phenanthrene, chrysene and dibenzanthracene enhanced the SCE frequency to a smaller extent. The number of anthracene-induced SCEs per metaphase was not increased as compared with the controls.
D000818:Animals; D002869:Chromosome Aberrations; D006224:Cricetinae; D003434:Crossing Over, Genetic / Q000187:drug effects; D005260:Female; D008297:Male; D009153:Mutagens; D011083:Polycyclic Compounds / Q000494:pharmacology*
D009153:Mutagens; D011083:Polycyclic Compounds