[Evidence of an ileal hormone inhibiting pancreatic secretion (ACP anticholecystokinine peptide)].
The contact of long and medium chain fatty acids with the ileal mucosa inhibits basal or stimulated pancreatic protein secretion of Man, Dog, Cat and Rat. This inhibition is due to an inhibitory factor transmitted by cross-circulation. We isolated from partially purified extracts of Pig ileum a peptide which inhibits strongly volume and protein pancreatic output of the conscious Rat. We propose to call this factor ACP, anticholecystokinine peptide.
D000818:Animals; D002415:Cats; D002766:Cholecystokinin / Q000037:antagonists & inhibitors* / Q000378:metabolism; D004285:Dogs; D006728:Hormones / Q000502:physiology*; D006801:Humans; D007082:Ileum / Q000502:physiology*; D007413:Intestinal Mucosa / Q000502:physiology; D010179:Pancreas / Q000378:metabolism*; D010455:Peptides / Q000502:physiology*; D051381:Rats
D006728:Hormones; D010455:Peptides; D002766:Cholecystokinin
Mise en évidence d'une hormone iléale inhibitrice de la sécrétion pancréatique (ACP: aticholécystokininepeptide).