[Pharmacogenetic aspects of the immunodepressive action of cyclophosphamide].
The alkylating and immunodepressive activity of the serum of CBA, BALB/c and DBA/2 mice was studied after the cyclophosphamide administration. The interstrain differences between the indices under study were revealed; no direct correlation was shown between them. DBA/2 mice were found to be the most sensitive to the immunodepressive action of cyclophosphamide, and had the highest blood serum immunodepressive activity.
D000478:Alkylation; D000818:Animals; D003520:Cyclophosphamide / Q000097:blood / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D007106:Immune Sera / Q000235:genetics / Q000276:immunology; D007125:Immunogenetics; D007165:Immunosuppression Therapy; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D013997:Time Factors
D007106:Immune Sera; D003520:Cyclophosphamide
Farmakogeneticheskie aspekty immunodepressivnogo deĭstviia tsiklofosfamida.