The effect of cerebellar stimulation on focal seizure activity and spasticity in monkeys.
Experiments were carried out in awake, unmedicated monkeys to determine the effect of application of current to the cerebellar hemispheres on electrically induced focal motor seizures and surgically induced spasticity. Application of current at various frequencies and pulse amplitudes did not significantly alter focal motor seizures but did significantly reduce spasticity. Analysis of evoked potential recordings carried out during various experimental procedures suggests that application of current to the cerebellar hemispheres may reduce cortical neuronal responsiveness.
D000818:Animals; D002525:Cerebellar Cortex / Q000503:physiopathology*; D004056:Differential Threshold / Q000187:drug effects; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects; D000882:Haplorhini; D008251:Macaca; D009128:Muscle Spasticity / Q000503:physiopathology* / Q000628:therapy; D010672:Phenytoin / Q000494:pharmacology; D012640:Seizures / Q000503:physiopathology*; D013003:Somatosensory Cortex / Q000503:physiopathology
D010672:Phenytoin