title: An ultrastructural study of the testis and epididymis of the rat after treatment with prostaglandins E2 and F2 alpha (PGE2 and PGF2 alpha).
abstract: Intratesticular injections of PGE2 and PGF2 alpha caused damage to germ cells and exfoliation of part of the damaged germinal epithelium into the epididymis. Membrane-bound granular bodies and localized swellings were also seen in some of the myoid cells in experimental animals. However, the Sertoli cells and Leydig cells remained unaffected.
mesh_terms: D000818:Animals; D003593:Cytoplasm / Q000648:ultrastructure; D004305:Dose-Response Relationship, Drug; D004822:Epididymis / Q000187:drug effects / Q000648:ultrastructure*; D008297:Male; D008854:Microscopy, Electron; D011458:Prostaglandins E / Q000494:pharmacology*; D011460:Prostaglandins F / Q000494:pharmacology*; D051381:Rats; D013094:Spermatozoa / Q000187:drug effects; D013737:Testis / Q000187:drug effects / Q000648:ultrastructure*
chemical_list: D011458:Prostaglandins E; D011460:Prostaglandins F