title: [Inhibition of biological methylations by t,t-farnesylacetone, a constituant of the androgenic gland of the male crab, Carcinus maenas].
abstract: t, t-farnesylacetone 1 and hexahydrofarnesylacetone 2 have been previously identified in extracts from the androgenic gland of the male Crab Carcinus maenas. These compounds inhibit in vitro the methylation of E. coli B tRNA and of Calf thymus histones with S-adenosylmethionine methyl-14C as methyl donor and methylases from Crab testis. Rat liver or a 1-adenine methylase from a Mouse plasmocytoma (1 is approximately 200 times more active than 2).
mesh_terms: D000818:Animals; D003386:Brachyura; D006657:Histones / Q000378:metabolism; D007659:Ketones / Q000494:pharmacology; D008099:Liver / Q000201:enzymology; D008297:Male; D008780:Methyltransferases / Q000037:antagonists & inhibitors*; D051379:Mice; D012343:RNA, Transfer / Q000378:metabolism; D051381:Rats; D012436:S-Adenosylmethionine / Q000378:metabolism; D013729:Terpenes / Q000494:pharmacology*; D013737:Testis / Q000201:enzymology
chemical_list: D006657:Histones; D007659:Ketones; D013729:Terpenes; D012436:S-Adenosylmethionine; D012343:RNA, Transfer; D008780:Methyltransferases
vernacular_title: Inhibition de méthylations biologiques par ia t,t-farnésylacétone, constituant de la glande androgène du crabe mâle Carcinus maenas.