title: Effects of CCNU on hematopoiesis in rats.
abstract: The effect of orally administered CCNU on proliferating and cytokinetically "resting" bone marrow cells was studied in rats. The resting bone marrow cells were selectively labeled with 3H-thymidine by the "complete 3H-thymidine labeling method." The results show a reduction in the number of absolute bone marrow cells to about 40% of the original value in 3 days. Regeneration was completed only after 22 days. No difference was found in the destructive or the regenerative pattern of CFU-C, myelopoietic, erythropoietic, lymphatic, or megakaryocytic cells. Resting and proliferating cells of the bone marrow were equally affected by CCNU.
mesh_terms: D000818:Animals; D001773:Blood Cells / Q000187:drug effects; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D002455:Cell Division / Q000187:drug effects; D006410:Hematopoiesis / Q000187:drug effects*; D008130:Lomustine / Q000494:pharmacology*; D009607:Nitrosourea Compounds / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
chemical_list: D009607:Nitrosourea Compounds; D008130:Lomustine