title: Clinical considerations of the ratio of myocardial oxygen demand to available supply.
abstract: Myocardial oxygen demand is the relationship between the inherent needs of the heart and the available oxygenated blood reaching the myocardial tissue. The system is controlled by two different, yet not wholly uncomplementary, mechanisms. The first, coronary blood flow, appears to be regulated primarily by tissue oxygen tension. The second, the determinants of myocardial oxygen consumption, is controlled more by the heart's mechanical performance than the tissue oxygen tension. Currently available antianginal drugs and physical training affect these two mechanisms and may alter angina pectoris.
mesh_terms: D003326:Coronary Circulation / Q000187:drug effects; D003327:Coronary Disease / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D009206:Myocardium / Q000378:metabolism*; D005996:Nitroglycerin / Q000494:pharmacology / Q000627:therapeutic use; D010100:Oxygen; D010101:Oxygen Consumption; D010313:Partial Pressure; D011433:Propranolol / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D011433:Propranolol; D005996:Nitroglycerin; D010100:Oxygen