[Effect of folic acid on metabolic processes in wounds].
In experiments on rats the effect of folic acid on the redox and energy-producing processes as well as upon the synthesis of collagen and protein fractions of the muscular tissue in the area of the wound was investigated. Low doses of folic acid are shown to intensify in the muscles of intact animals anaerobic, and in the wound muscles--aerobic processes. High doses of folic acid produce an opposite effect on the wound muscles, by intensifying anaerobic processes. Folic acid manifests itself as an activator of anabolic processes by intensifying the gluconeogenesis in the wound tissues, the biosynthesis of collagen in the muscles of intact animals, and to a lesser degree in the muscles of surgically treated animals.
D000818:Animals; D003094:Collagen / Q000096:biosynthesis; D005492:Folic Acid / Q000494:pharmacology*; D006003:Glycogen / Q000378:metabolism; D006097:Granulation Tissue / Q000187:drug effects* / Q000378:metabolism; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D009124:Muscle Proteins / Q000096:biosynthesis; D009132:Muscles / Q000293:injuries* / Q000378:metabolism; D051381:Rats; D012867:Skin / Q000293:injuries* / Q000378:metabolism; D014945:Wound Healing / Q000187:drug effects*
D007527:Isoenzymes; D009124:Muscle Proteins; D006003:Glycogen; D003094:Collagen; D005492:Folic Acid; D007770:L-Lactate Dehydrogenase
Osobennosti vliianiia folievoĭ kisloty na metabolicheskie protsessy v rane.