In vitro mutagenicity and cell transformation screening of caprolactam.
Caprolactam was tested for genetic activity in bacterial and mammalian screens. It was inactive in the following tests: a) Salmonella/microsome mutagenicity; b) Chinese hamster ovary cell mutagenicity (induction of 6-thioguanine mutants); c) Enhancement of SA7 virus transformation of primary hamster embryo cells, when administered before or after virus, and; d) Chemical transformation of secondary hamster embryo cells.
D000818:Animals; D001381:Azepines / Q000494:pharmacology*; D002209:Caprolactam / Q000494:pharmacology*; D002460:Cell Line; D002472:Cell Transformation, Viral; D006224:Cricetinae; D003412:Cricetulus; D005260:Female; D009152:Mutagenicity Tests; D009153:Mutagens; D010053:Ovary; D012486:Salmonella typhimurium / Q000235:genetics
D001381:Azepines; D009153:Mutagens; D002209:Caprolactam