[Action of sustained release nitroglycerin on a pulmonary artery pressure in coronary heart disease (author's transl)].
In 12 patients with coronary heart disease and increased left ventricular filling pressure the pressure lowering effect of an oral long-acting nitroglycerin preparation (Sustac-Retard forte) was investigated at rest (n = 6) and during exercise (n = 6). The systolic and end-diastolic pulmonary artery pressure decreased significantly for up to 6 hours after the ingestion of 6.5 mg of nitroglycerin. The most marked pressure changes in the pulmonary circulation occurred 2 to 4 hours after ingestion of the tablets. All patients noticed reduction of dyspnoea and (or) anginal pain.
D000368:Aged; D000787:Angina Pectoris; D001794:Blood Pressure / Q000187:drug effects*; D003327:Coronary Disease / Q000188:drug therapy*; D003692:Delayed-Action Preparations; D004417:Dyspnea; D006801:Humans; D008875:Middle Aged; D005996:Nitroglycerin / Q000494:pharmacology* / Q000627:therapeutic use; D011651:Pulmonary Artery; D013997:Time Factors
D003692:Delayed-Action Preparations; D005996:Nitroglycerin
Wirkung von Retard-Nitroglycerin auf den Pulmonalarteriendruck bei koronarer Herzkrankheit.