Effects of pure chlorobiphenyls (2,4',5-trichlorobiphenyl or 2,2',4,4',5,5'-hexachlorobiphenyl) on the disappearance of 14C from the  blood plasma after intravenous injection of 4-14C-progesterone and on the hepatic drug metabolizing system in the female rat.
Effects of two pure chlorobiphenyls (2,4',5-trichlorobiphenyl or 2,2',4,4',5,5'-hexachlorobiphenyl) on the hepatic drug metabolizing system and on the elimination rate of 14C from the blood after intravenous injection of 4(-14)C- progesterone have been studied in the female rat. The results obtained show that females pre-treated with small amounts of 2,2',4,4'5,5'-hexachlorobiphenyl (o.5 mg/day for 14 consecutive days) have significantly higher elimination rates of 14C (originating from intravenous injection of 4(-14C-progesterone) from the blood plasma, significantly higher content of hepatic cytochrome P-450 and significantly heavier livers than control females. On the other hand, trichlorobiphenyl (0.5 mg/day for 14 consecutive days) do not differ significantly from the results obtained from control females.
D000284:Administration, Oral; D000818:Animals; D002250:Carbon Radioisotopes; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005260:Female; D006207:Half-Life; D007275:Injections, Intravenous; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D009929:Organ Size / Q000187:drug effects; D011078:Polychlorinated Biphenyls / Q000008:administration & dosage / Q000494:pharmacology*; D011374:Progesterone / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D002250:Carbon Radioisotopes; D011374:Progesterone; D003577:Cytochrome P-450 Enzyme System; D011078:Polychlorinated Biphenyls