Attempts to induce immunological enhancement for kidney allografts in rhesus monkeys.
Various rhesus alloantisera were tested for their capacity to induce enhancement of kidney allograft survival in D locus-incompatible rhesus monkeys. Six experimental groups were investigated: 1, ten allografted monkeys remained untreated; 2, six recipients were treated with Imuran and prednisolone; 3, eight rhesus monkeys were treated with a polyspecific "anti-SD" serum; 4, four animals were given oligospecific antikidney serum; 5, four monkeys were treated with oligospecific antiblood serum; and 6, nine recipients were given anti-Ia-like sera plus immunosuppressive treatment with Imuran and prednisolone. It was found that neither treatment with Imuran and prednisolone nor the administration of any of the alloantisera had a substantial effect on kidney graft survival. However, there appeared to be a difference in renal function among experimental groups. At 6 days after grafting, the mean blood urea level in the group treated with Ia-like antisera was found to be significantly lower than those of all other groups. It is discussed that this favourable effect is attributable to treatment with anti-Ia-like sera and not to the additional factors (conventional immunosuppression and partial matching for Ia-like antigens) occurring in this experimental group.
D000818:Animals; D000936:Antigen-Antibody Complex; D001379:Azathioprine / Q000494:pharmacology; D001402:B-Lymphocytes / Q000276:immunology*; D006085:Graft Survival / Q000187:drug effects; D000882:Haplorhini; D006649:Histocompatibility Antigens; D007106:Immune Sera; D007165:Immunosuppression Therapy / Q000379:methods*; D007518:Isoantibodies; D007519:Isoantigens; D007668:Kidney / Q000276:immunology; D016030:Kidney Transplantation; D008251:Macaca; D008253:Macaca mulatta; D011239:Prednisolone / Q000494:pharmacology; D014184:Transplantation, Homologous
D000936:Antigen-Antibody Complex; D006649:Histocompatibility Antigens; D007106:Immune Sera; D007518:Isoantibodies; D007519:Isoantigens; D011239:Prednisolone; D001379:Azathioprine