Effect of cobra venom factor on the response of Wistar-Furth rats to the Gross-virus-induced (C58NT)D lymphoma.
Wistar-Furth rats were injected with the anticomplementary cobra venom factor at the time of challenge with the Gross-virus-induced (C58NT)D lymphoma. Complement depletion and/or activation of the complement system in these animals led to the following findings: Multiplication of the tumor cells in vivo was accelerated and mortality rates were enhanced. In addition, serum levels of the immunoglobulins which mediate antibody-dependent cellular cytotoxicity were depressed.
D000406:AKR murine leukemia virus; D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity; D002471:Cell Transformation, Neoplastic; D003176:Complement C3 / Q000172:deficiency; D004546:Elapid Venoms / Q000494:pharmacology*; D008223:Lymphoma / Q000276:immunology* / Q000401:mortality; D008297:Male; D051381:Rats; D011920:Rats, Inbred WF; D013997:Time Factors
D003176:Complement C3; D004546:Elapid Venoms