A defect in neutrophil motility in two siblings with recurrent infections and a remarkable family history.
Two siblings with recurrent infections were found to have impaired neutrophil motility. The same association of infections (otitis media, bronchitis, chronic diarrhoea) has caused seven fatalities in the paternal side of the family, suggesting genetic implications.
D001424:Bacterial Infections / Q000235:genetics* / Q000503:physiopathology; D002634:Chemotaxis, Leukocyte; D002648:Child; D003967:Diarrhea / Q000235:genetics; D005260:Female; D006801:Humans; D007223:Infant; D007558:Italy; D008297:Male; D009504:Neutrophils / Q000502:physiology; D010033:Otitis Media / Q000235:genetics; D010375:Pedigree; D012008:Recurrence; D012141:Respiratory Tract Infections / Q000235:genetics