Diurnal 18-hydroxy-11-deoxycorticosterone pattern in human stable hypertension.
Diurnal 18-hydroxy-11-deoxycorticosterone (18-OH-DOC) pattern was studied with RIA technique in 33 hypertensive patients in supine position and on normal sodium diet. The compound was evaluated every 2 h from 0800-2000 h. Simultaneously, plasma aldosterone and cortisol were measured. Abnormal 18-OH-DOC behavior was observed in only 2 out of 4 patients with Cushing's disease, while sporadic and slight elevations, synchronous with F, were seen in 5 out of 24 stable essential hypertensive patients [1 with normal plasma renin activity (PRA), 1 with low PRA, and 3 with high PRA]. 18-OH-DOC was normal in 2 cases of hypertension due to renal artery stenosis, in 1 patient with nephrosclerosis, and in 1 patient with horseshoe kidney. From these results, 18-OH-DOC does not seem to play an important pathogenetic role in stable essential hypertension, considering also the low mineralocorticoid activity of the compound.
D015070:18-Hydroxydesoxycorticosterone / Q000097:blood*; D000293:Adolescent; D000328:Adult; D000450:Aldosterone / Q000097:blood; D002940:Circadian Rhythm; D003480:Cushing Syndrome / Q000150:complications; D003900:Desoxycorticosterone / Q000031:analogs & derivatives*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D006973:Hypertension / Q000097:blood* / Q000209:etiology; D007674:Kidney Diseases / Q000150:complications; D008297:Male; D009400:Nephrosclerosis / Q000150:complications; D012078:Renal Artery Obstruction / Q000150:complications; D012083:Renin / Q000097:blood
D015070:18-Hydroxydesoxycorticosterone; D003900:Desoxycorticosterone; D000450:Aldosterone; D012083:Renin; D006854:Hydrocortisone