The pedicle in neurofibromatosis.
Three cases of von Recklinghausen's disease (neurofibromatosis) are described, one with agenesis of a pedicle, another with multiple hypoplastic pedicles, and a third with bilateral hypoplastic pedicles producing a spondylolistesis. These peidcle deficiencies are manifestations of mesodermal dysplasia. Agenesis of the pedicle most likely represents a defect in chondrification. Hypoplasia probably represents a partial lack of development of the pedicle and the ipsilateral arch. Hypoplasia or agenesis of a pedicle should suggest the possibility of underlying neurofibromatosis.
D000293:Adolescent; D001848:Bone Diseases, Developmental / Q000000981:diagnostic imaging / Q000209:etiology*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D009456:Neurofibromatosis 1 / Q000150:complications* / Q000000981:diagnostic imaging; D011859:Radiography; D013131:Spine / Q000002:abnormalities* / Q000000981:diagnostic imaging; D013168:Spondylolisthesis / Q000000981:diagnostic imaging / Q000209:etiology