Antileukemic activity of substituted ureidothiazoles, ureidothiadiazoles, and related compounds.
A number of ureidothiazole and ureidothiadiazole derivatives related to ethyl 4-[[(2-thiazolylamino)carbonyl]-amino]benzoate were prepared and evaluated against the leukemia P-388 tumor system in mice. Preliminary structure-activity relationship study revealed that, among other considerations, active compounds of this series contain either an "isothioureido" [N-C(S-)=N-] or an "isothiosemicarbazono" [N-C(S-)=N-N=] structural unit.
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D007942:Leukemia, Experimental / Q000188:drug therapy; D051379:Mice; D013329:Structure-Activity Relationship; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D014508:Urea / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
D000970:Antineoplastic Agents; D013830:Thiadiazoles; D013844:Thiazoles; D014508:Urea