Interaction between narcotic antagonist (naloxone) and lysergic acid diethylamide (LSD) in the rat.
LSD administration in rats elicited a diphasic reaction consisting of a brief excitable period ( up to 8 min) followed by a prolonged catalepsy (8 min-1 h). While the cataleptic response was antagonized by a single injection of naloxone (given 30 min after LSD administration), pretreatment with naloxone shortened the excitable phase and potentiated the catalepsy.
D000818:Animals; D002375:Catalepsy / Q000139:chemically induced*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008238:Lysergic Acid Diethylamide / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D009270:Naloxone / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D009270:Naloxone; D008238:Lysergic Acid Diethylamide