Nocardicin A, a new monocyclic beta-lactam antibiotic IV. Factors influencing the in vitro activity of Nocardicin A.
Factors influencing the in vitro antimicrobial activity of nocardicin A against Pseudomonas aeruginosa and Proteus mirabilis were investigated. Sodium chloride was identified as a major inhibitor. Some of the amino acids, sugars and divalent cations were found to be minor inhibitors. The presence of potassium phosphates enhanced nocardicin A activity against P. aeruginosa, but antagonized the activity against P. mirabilis.
D000596:Amino Acids / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000037:antagonists & inhibitors*; D002118:Calcium / Q000494:pharmacology; D003470:Culture Media; D005947:Glucose / Q000494:pharmacology; D008274:Magnesium / Q000494:pharmacology; D010710:Phosphates / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology; D011513:Proteus mirabilis / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012965:Sodium Chloride / Q000494:pharmacology; D047090:beta-Lactams / Q000037:antagonists & inhibitors*
D000596:Amino Acids; D000900:Anti-Bacterial Agents; D003470:Culture Media; D010710:Phosphates; D047090:beta-Lactams; D012965:Sodium Chloride; D008274:Magnesium; D005947:Glucose; D011188:Potassium; D002118:Calcium