Transfer of antibacterial immunity by "Immune" RNA from animals treated with pseudomonas lipopolysaccharide.
The humoral primary immune response to Pseudomonas aeruginosa lipopolysaccharide was studied. Mice immunized with various doses of LPS developed anti-LPS antibodies. Antibody activity was due to 19S and 7S immunoglobulins. Extracts rich in RNA from spleen cells of immune mice were able to transfer specific anti-LPS response to normal recipients. Immunogenic antigen contamination of RNA was ruled out by a variety of controls.
D000818:Animals; D000917:Antibody Formation; D007116:Immunization, Passive; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008070:Lipopolysaccharides; D051379:Mice; D011135:Polysaccharides, Bacterial; D011550:Pseudomonas aeruginosa / Q000276:immunology; D012313:RNA; D013154:Spleen / Q000276:immunology
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008070:Lipopolysaccharides; D011135:Polysaccharides, Bacterial; D012313:RNA