Effect of pemphigus antibodies on desmosomal structure in vitro.
Changes in desmosomes were noted in nonacantholytic regions of skin explants cultured in the presence of intercellular antibodies. These changes included dissociation of desmosomes, as well as a "selective loss" of desmosomal components in one or both of neighboring cells.
D000051:Acantholysis / Q000276:immunology / Q000473:pathology; D000818:Animals; D000906:Antibodies / Q000008:administration & dosage*; D002450:Cell Communication / Q000187:drug effects; D003896:Desmosomes / Q000187:drug effects / Q000276:immunology / Q000648:ultrastructure*; D000882:Haplorhini; D006801:Humans; D008253:Macaca mulatta; D010392:Pemphigus / Q000276:immunology* / Q000473:pathology; D012867:Skin / Q000276:immunology / Q000648:ultrastructure
D000906:Antibodies