On the pathogenesis of stone formation in stone-eliminating patients.
The clinical peculiarities, and the etiological and pathogenetic factors of urolithiasis in 296 patients suffering from spontaneous stone elimination were studied. It was established that 209 patients eliminated stones consisting of uric acid, sodium salts and ammonium salts. Moderate hypocalcemia and hyperphosphatemia and also hyperuricemia and hyperuricuria were present. There were 39 'eliminators' of calcium stones. Their blood calcium content was higher, hypercalciuria, inorganic phosphorus and normal uric acid, were noted. Compound stones were present in 48 observations. When carrying out additional biochemical tests in 57 patients with calcium and compound stones, primary hyperparathyroidism was diagnosed in 34 observations; and parathyroidectomy was successfully performed.
D000328:Adult; D002118:Calcium / Q000378:metabolism; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000150:complications; D008297:Male; D008875:Middle Aged; D010070:Oxalates / Q000378:metabolism; D010756:Phosphoric Acids / Q000378:metabolism; D012492:Salts; D014527:Uric Acid / Q000096:biosynthesis / Q000378:metabolism; D014545:Urinary Calculi / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism
D010070:Oxalates; D010756:Phosphoric Acids; D012492:Salts; D014527:Uric Acid; D002118:Calcium