title: [Behaviour of the ST segment under stress by atrial frequency and digitalis in latent coronary insufficiency (author's transl)].
abstract: Therapeutic doses of digitalis may give rise to depressions and abnormities of the ST segment. In coronary patients this is occasionally also associated with anginal complaints. In 7 patients the ST segment was investigated at rest and under increasing stress by atrial frequency without and with digitalis at increasing therapeutic dosage. In all patients a glycoside-induced, linearly intensifying depression of the ST segment was demonstrated as a regular and dose-dependent pattern the onset of which was already recognizable at an average effective level of 0,59 mg digoxin. The opinion is held that glycoside-induced ST depressions in the ECG are not in general of insignificant nature but may be the reflection of myocardial ischemia.
mesh_terms: D000368:Aged; D000787:Angina Pectoris / Q000139:chemically induced; D003327:Coronary Disease / Q000175:diagnosis / Q000503:physiopathology*; D004077:Digoxin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D004562:Electrocardiography; D005260:Female; D006321:Heart / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption / Q000187:drug effects
chemical_list: D004077:Digoxin
vernacular_title: Verhalten der ST-Strecke unter Frequenzbelastung und Digitalis bei latenter Koronarinsuffizienz