Changes in the red blood cell membrane in protein-calorie malnutrition.
Ten children with protein-calorie malnutrition (five with kwashiorkor, three with marasmus, and two with marasmic-kwashiorkor) were studied at hospital admission and during recovery for evidence of changes in red blood cell lipids, osmotic fragility, and chromium survival. On admission, the children had significantly higher-than-normal red blood cell membrane cholesterol and phospholipid, and an elevated cholesterol:phospholipid ratio. Both red blood cell osmotic fragility and red cell survivals were depressed. These measurements returned to normal limits with recovery.
D002675:Child, Preschool; D002784:Cholesterol / Q000097:blood; D002857:Chromium / Q000097:blood; D004905:Erythrocyte Aging; D004910:Erythrocyte Membrane / Q000502:physiology*; D004912:Erythrocytes / Q000502:physiology*; D006801:Humans; D007223:Infant; D007501:Iron / Q000097:blood; D009996:Osmotic Fragility; D010743:Phospholipids / Q000097:blood; D011502:Protein-Energy Malnutrition / Q000097:blood*
D010743:Phospholipids; D002857:Chromium; D002784:Cholesterol; D007501:Iron