Toxicity of Pseudomonas aeruginosa exotoxin A for human macrophages.
Pseudomonas aeruginosa exotoxin A was toxi in vitro for human peripheral blood macrophages. Cytotoxicity, manifested by morphological evidence of cell death and inhibition of [3H]thymidine uptake, followed exposure to as little as 10 ng of exotoxin per ml for 1 h. In addition, phagocytosis of heat-killed Candida albicans by macrophages exposed to sublethal concentrations of exotoxin was impaired. This cytotoxicity was neutralizable with antiexotoxin serum.
D000992:Antitoxins / Q000494:pharmacology; D001427:Bacterial Toxins / Q000633:toxicity*; D003603:Cytotoxins / Q000633:toxicity; D005098:Exotoxins / Q000633:toxicity*; D006801:Humans; D008264:Macrophages / Q000187:drug effects*; D010587:Phagocytosis / Q000187:drug effects; D011550:Pseudomonas aeruginosa; D013936:Thymidine / Q000378:metabolism
D000992:Antitoxins; D001427:Bacterial Toxins; D003603:Cytotoxins; D005098:Exotoxins; D013936:Thymidine