Cytogenetic and immunoglobulin markers of human leukemic B-cell lines.
This study describes the establishment of two permanent leukemic B-cell lines (BALM-1 and -2) originating from the blood cells of a patient with a B-cell type of acute lymphoblastic leukemia. The cells of BALM-1 and -2 exhibited cell surface markers compatible with B-cell origin. The identity between the leukemic cells in vivo and those of the BALM lines was established on the basis of the karyotypic picture, including marker chromosomes 14q+ and t(12;17;?) and cell surface immunoglobulins (K, delta, and mu chain determinants).
D000951:Antigens, Neoplasm; D001402:B-Lymphocytes / Q000276:immunology* / Q000648:ultrastructure; D002460:Cell Line; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000648:ultrastructure; D002901:Chromosomes, Human, 13-15; D002902:Chromosomes, Human, 16-18; D002906:Chromosomes, Human, 6-12 and X; D006801:Humans; D007072:Immunoglobulin D; D007075:Immunoglobulin M; D007138:Immunoglobulin delta-Chains; D007145:Immunoglobulin kappa-Chains; D007148:Immunoglobulin mu-Chains; D007945:Leukemia, Lymphoid / Q000235:genetics* / Q000276:immunology*; D009374:Neoplasms, Experimental / Q000235:genetics / Q000276:immunology; D011947:Receptors, Antigen, B-Cell; D014178:Translocation, Genetic
D000951:Antigens, Neoplasm; D007072:Immunoglobulin D; D007075:Immunoglobulin M; D007138:Immunoglobulin delta-Chains; D007145:Immunoglobulin kappa-Chains; D007148:Immunoglobulin mu-Chains; D011947:Receptors, Antigen, B-Cell