[Experimental study of the myelotoxic effect of tomizine].
In tests conducted on 220 rats with transplantable sarcoma M-1 and intact animals acute toxicity, antineoplastic effect and the action on the blood system of tomizine, a new neoplastic drug of the group of the folic acid antagonists, were studied. Investigation involved a single intraperitoneal injection of the drug in DL50/30 and MTD. The compound is shown to exert an inhibiting action on the development of sarcoma M-1 and lengthens the survival of the tumour-stricken animals, without producing any pronounced myelotoxic effect. The disclosed shifts on the level of the periphedal blood and marrow were short-lived and concerned mainly the erythroid germ cells.
D000741:Anemia, Aplastic / Q000139:chemically induced* / Q000473:pathology; D000818:Animals; D001853:Bone Marrow / Q000473:pathology; D005493:Folic Acid Antagonists / Q000009:adverse effects / Q000633:toxicity*; D051381:Rats; D012513:Sarcoma, Experimental / Q000188:drug therapy*; D013843:Thiazines / Q000633:toxicity*; D013997:Time Factors
D005493:Folic Acid Antagonists; D013843:Thiazines; C012066:tomizine
K izucheniiu mielotoksicheskogo deĭstviia tomizina v éksperimente.