Increase of serum thyrotropin (TSH) os suckling rats after thyroliberin (TRH) injection to lactating mothers.
Injection of 50 microgram TRH to lactating rats 15 days after parturition was followed 4 h after treatment by an increase of serum TSH and a decrease of absolute and relative pituitary TSH content in suckling pups when compared to sucklings of saline-treated mothers. The weight of the pituitary and thyroid also decreased. Results indicate that TRH administered to lactating rats induces release of TSH from the pituitary of suckling pups. An increase of the variability of serum TSH and a decrease of pituitary TSH content at noon in pups of saline-treated mothers suggest the presence of diurnal variation of TSH secretion in 15-day-old rats.
D000818:Animals; D005260:Female; D007774:Lactation / Q000187:drug effects*; D010903:Pituitary Gland, Anterior / Q000378:metabolism; D011247:Pregnancy; D051381:Rats; D012636:Secretory Rate / Q000187:drug effects; D013972:Thyrotropin / Q000097:blood / Q000378:metabolism*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*; D014886:Weaning
D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin