Comparison of susceptibility of Neisseria meningitidis to sodium sulphadiazine and sodium fusidate in vitro.
Out of 100 strains of meningococci examined 62 were resistant to 1 mg/l or more of sodium sulphadiazine, including 82% of group W135 strains and 69% of group B strains. All strains were sensitive in vitro to 0.5 mg/l of sodium fusidate. Sodium fusidate should be considered as a chemoprophylactic agent for those who may be at risk of meningococcal disease.
D004352:Drug Resistance, Microbial; D005672:Fusidic Acid / Q000494:pharmacology*; D009345:Neisseria meningitidis / Q000187:drug effects*; D012703:Serotyping; D013411:Sulfadiazine / Q000494:pharmacology*
D013411:Sulfadiazine; D005672:Fusidic Acid