Effect of thiamine hydrochloride on the blood level of 2-formyl 1-methyl pyridinium oxime chloride (2-PAM.C1) in rats.
The biological half-life of 2-PAM.C1 was found to increase in female rats pretreated with thiamine hydrochloride (10 mg/kg i.m.). No such effect was observed in the male rats.
D000818:Animals; D005260:Female; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D011220:Pralidoxime Compounds / Q000097:blood*; D051381:Rats; D012737:Sex Factors; D013831:Thiamine / Q000494:pharmacology*
D011220:Pralidoxime Compounds; D013831:Thiamine