title: Hemodynamic assessment of the glutaraldehyde-preserved porcine heterograft in the aortic and mitral positions.
abstract: Although glutaraldehyde-preserved porcine heterograft (PH) valves may have a lowered incidence of thromboembolism compared to mechanical valves, data concerning postoperative function in PH valves are incomplete. Accordingly, 26 patients receiving PH in the aortic (AO) or mitral position (MIT) were studied at cardiac postoperative catheterization (mean 19 weeks). The 12 AO patients had an average peak systolic gradient of 19 mm Hg (range 3-52 mm Hg); mean valve area (VA) 1.33 cm2 (0.75-2.5; two patients had postoperative aortic insufficiency. The 14 MIT patients had a mean gradient of 7.9 mm Hg (0-13.1); VA 1.84 cm2 (0.70-3.2; postoperative mitral regurgitation occurred in two patients. AO stent diameter (SD) related to VA, r = 0.85; and peak gradient, r = -0.75. However, MIT SD did not relate to VA or peak gradient. At the 14-month follow-up examination 9 of 11 AO and 7 of 11 MIT patients improved by at least one functional class. Thus, with the advantage of reduced thromboembolism and generally satisfactory valve hemodynamics, further clinical trial of glutaraldehyde-preserved porcine heterografts is justified.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000447:Aldehydes; D000818:Animals; D001021:Aortic Valve / Q000503:physiopathology / Q000637:transplantation*; D006328:Cardiac Catheterization; D002302:Cardiac Output; D005260:Female; D005976:Glutaral; D006349:Heart Valve Diseases / Q000503:physiopathology / Q000601:surgery; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000503:physiopathology / Q000637:transplantation*; D009926:Organ Preservation; D013552:Swine; D014183:Transplantation, Heterologous
chemical_list: D000447:Aldehydes; D005976:Glutaral