Action of cinnarizine on the hyperviscosity of blood in patients with peripheral obliterative arterial disease.
Cinnarizine, a drug capable of improving blood flow, was studied for its action on blood viscosity and its main components in patients affected by peripheral obliterative arterial diseases (POAD). Both acute and chronic administration of the drug diminished the increased whole-blood viscosity in patients, without affecting plasma and serum viscosity, hematocrit, plasma fibrinogen concentration, and plasma osmolality. Since cinnarizine also led to a significant increase of peripheral muscular blood flow, it was hypothesized that this action may be due to an increased deformability of the red cells, and may play a considerable role in the therapeutic approach to POAD.
D001157:Arterial Occlusive Diseases / Q000097:blood*; D001809:Blood Viscosity / Q000187:drug effects*; D002936:Cinnarizine / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000494:pharmacology*
D010879:Piperazines; D002936:Cinnarizine