Studies on the ionophorous antibiotics. XI. The artifacts and the degradation products of lysocellin.
Lysocellin is a new polyether antibiotic produced by Streptomyces cacaoi var. asoensis and is characterized as a broad spectrum ionophore having a higher complexation affinity for divalent cations than for monovalents and also having an ability to transport biological amines. The structures of two artifacts designated L1 and M1 have been elucidated based on spectral evidence, and the formation mechanism of these compounds was discussed with respect to the reactivity of the antibiotic. In addition, a number of degradation and modified products were prepared in order to examine their biological activity and to utilize as the model compounds for 13C-NMR assignment.
D000107:Acetylation; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D004987:Ethers / Q000032:analysis / Q000494:pharmacology; D008401:Gas Chromatography-Mass Spectrometry; D007476:Ionophores / Q000032:analysis / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D004987:Ethers; D007476:Ionophores