Experimental toxemia in the pregnant primate.
In order to develop a model for the study of eclamptogenic toxemia, a series of experiments were carried out on 31 female baboons. In Group 1, consisting of 10 animals, metal clips were placed around the uterine arteries in order to partially occlude them, and the ovarian vessels were transected. The animals were subsequently mated. Nine developed hypertension and proteinuria, and one aborted. The renal lesions in these animals were indistinguishable from those described in human toxemia. Group 2 consisted of three of the 10 baboons from Group 1, which became pregnant a second time. They again developed hypertension and proteinuria. In Group 3, three baboons at 100 days of gestation were treated as in Group 1 with similar results. Groups 4 and 5 served as pregnant (3) and nonpregnant (15) controls. It is concluded that a toxemia model has been developed in a subhuman primate. This model will prove useful in the further study of eclamptogenic toxemia.
D000818:Animals; D001706:Biopsy; D001794:Blood Pressure; D002302:Cardiac Output; D004195:Disease Models, Animal; D004727:Endothelium / Q000648:ultrastructure; D004847:Epithelial Cells; D004848:Epithelium / Q000648:ultrastructure; D005260:Female; D005455:Fluorescent Antibody Technique; D000882:Haplorhini; D007511:Ischemia; D007678:Kidney Glomerulus / Q000473:pathology; D010215:Papio; D010920:Placenta / Q000098:blood supply*; D011225:Pre-Eclampsia / Q000150:complications / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D011247:Pregnancy; D011507:Proteinuria / Q000209:etiology; D014599:Uterus / Q000098:blood supply*; D014655:Vascular Resistance