title: Scintigraphic assessment of technetium 99m-diphosphonate uptake, vascularity and vessel permeability in human bone tumours.
abstract: Differences in the rate of uptake of 99Tcm-diphosphonate were found in 20 human bone tumours investigated. As some tumours have a slow rate of uptake it is suggested that the time used for routine scintigraphy at 3 hours is not always optimal and a further study should be performed in some cases. Various degrees of tumour vascularity and vessel permeability were found. The rate of diphosphonate uptake correlates with the vascularity, while it does not correlate with permeability which is generally increased as compared to normal bone.
mesh_terms: D001859:Bone Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging / Q000378:metabolism*; D002199:Capillary Permeability; D004164:Diphosphonates / Q000378:metabolism*; D006801:Humans; D009362:Neoplasm Metastasis; D011877:Radionuclide Imaging; D013667:Technetium / Q000378:metabolism*; D013997:Time Factors
chemical_list: D004164:Diphosphonates; D013667:Technetium