title: Reagin-mediated hypersensitivity reaction in the rat hindpaw and its inhibition by antianaphylactic drugs.
abstract: Immediate hypersensitivity reactions are usually studied locally by the passive cutaneous anaphylaxis method. In the present experiments reaginic antibody-induced hypersensitivity was produced in the rat hindpaw (passive paw anaphylaxis or PPA). Increased vascular permeability was determined by measuring the increase in paw volume. The reaction in the paw and its inhibition with antianaphylactic drugs was found to be similar to that in the skin. The PPA is fast and easy to perform and can be used to study hypersensitivity reactions in the rat.
mesh_terms: D000628:Aminophylline / Q000627:therapeutic use*; D000818:Animals; D004205:Cromolyn Sodium / Q000627:therapeutic use*; D003533:Cyproheptadine / Q000627:therapeutic use*; D004487:Edema / Q000517:prevention & control*; D006614:Hindlimb; D006969:Hypersensitivity, Immediate; D007158:Immunologic Techniques; D007545:Isoproterenol / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D011935:Reagins
chemical_list: D011935:Reagins; D000628:Aminophylline; D003533:Cyproheptadine; D007545:Isoproterenol; D004205:Cromolyn Sodium