title: The effect of intracarotid infusion of dexamethasone and 5-hydroxytryptamine on cerebral blood flow and metabolism in baboons.
abstract: The effect of intracarotid infusion of dexamethasone on cerebral blood flow and cerebral oxygen utilization was measured in baboons using the xenon-133 clearance technique. The cerebrovascular response to intracarotid infusion of 5-hydroxytryptamine (5-ht) was then determined during simultaneous infusion of the steroid. Infusion of dexamethasone alone and infusion with 5-HT produced no significant change in cerebral blood flow or cerebral oxygen utilization when compared to baseline values. The study indicates that neither dexamethasone nor 5-HT with dexamethasone modify cerebral blood flow when infused via the internal carotid artery.
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D002342:Carotid Artery, External; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D003907:Dexamethasone / Q000008:administration & dosage / Q000494:pharmacology*; D000882:Haplorhini; D007261:Infusions, Intra-Arterial; D010101:Oxygen Consumption / Q000187:drug effects*; D010215:Papio; D012701:Serotonin / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D012701:Serotonin; D003907:Dexamethasone