Latent expression of a Cgamma gene.
Rabbit 136 represented the first instance whereby more than two alleles for any immunoglobulin locus are detected phenotypically in a single animal. This was reported as the acquisition of the a2 and b6 markers in the animal nominally typed a1a3, b4b5 after intensive immunization. Follow-up studies indicate that another immunoglobulin marker, notably d11, also appeared in the postimmune serum. The d11 specificity was detected serologically by the hemagglutination-inhibition assay and chemically by analysis of the CNBr digestion products involving a strategic methionine.
D000818:Animals; D003488:Cyanogen Bromide / Q000494:pharmacology; D005796:Genes; D006385:Hemagglutination Inhibition Tests; D007106:Immune Sera; D007126:Immunoglobulin Allotypes; D007074:Immunoglobulin G; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D007142:Immunoglobulin gamma-Chains / Q000235:genetics*; D011817:Rabbits; D013997:Time Factors
D007106:Immune Sera; D007126:Immunoglobulin Allotypes; D007074:Immunoglobulin G; D007143:Immunoglobulin Heavy Chains; D007142:Immunoglobulin gamma-Chains; D003488:Cyanogen Bromide