The effect of TRH and a related tripeptide, L-N-(2-oxopiperidin-6-yl-carbonyl)-L-histidyl-L-thiazolidine-4-carboxamide (MK-771, OHT), on the depressant action of barbiturates and alcohol in mice and rats.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001463:Barbiturates / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D007858:Learning / Q000187:drug effects*; D008723:Methohexital / Q000494:pharmacology; D051379:Mice; D010424:Pentobarbital / Q000494:pharmacology; D051381:Rats; D012890:Sleep / Q000187:drug effects*; D013973:Thyrotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology*
D001463:Barbiturates; D000431:Ethanol; D013973:Thyrotropin-Releasing Hormone; D008723:Methohexital; D010424:Pentobarbital