Modulation by malaria infection of the induction of T lymphocyte-dependent delayed-type hypersensitivity and antibody formation to sheep erythrocytes in mice.
A profound alteration of the inductive phase of delayed-type hypersensitivity and antibody formation to SRBC was found in malaria infected mice when sensitization with this antigen was performed intravenously at a critical time of the disease, but not after subcutaneous immunization, suggesting a major role for the spleen in the mechanism of immunodepression.
D000818:Animals; D000917:Antibody Formation; D004306:Dose-Response Relationship, Immunologic; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006388:Hemagglutinins; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D008288:Malaria / Q000276:immunology*; D051379:Mice; D010962:Plasmodium berghei / Q000276:immunology; D012756:Sheep; D013601:T-Lymphocytes / Q000276:immunology*
D006388:Hemagglutinins