[Role of the Lewis (Le-le) and secretor (Se-se) systems in the rejection of kidney grafts].
ABH and Lewis antigens are secreted in distal convoluted and collector tubes of the kidney. The renal ABH secretion is genetically controlled by the Se-se system, while the Lewis specificities are controlled by the Le-le system. The secretory status of the recipient does not modify the probability of graft survival, while the Lewis phenotype seems to play a major role in rejection. The probability of graft survival at 2 years in le-le homozygous recipients (29%) is much lower than that of Le recipients (58%) p less than 0.01.
D000017:ABO Blood-Group System / Q000235:genetics*; D006084:Graft Rejection; D006801:Humans; D007668:Kidney / Q000276:immunology; D016030:Kidney Transplantation; D007983:Lewis Blood Group Antigens / Q000235:genetics; D012463:Saliva / Q000276:immunology; D014184:Transplantation, Homologous
D000017:ABO Blood-Group System; D007983:Lewis Blood Group Antigens
Rôle des systèmes Lewis (Le-le) et sécréteur (Se-se) dans le rejet des greffes rénales.