A comparative trial of liquid lomotil and mist kaolin in childhood diarrhoea.
Lomotil liquid in a dose of 0.3 mg/kg/day has been compared with plain mist kaolin in controlling acute diarrhoea in young children aged 6 weeks to 2 years. Lomotil was found to stop the diarrhoea faster and significantly shorten the period of hospital admission than kaolin (P less than 0.05) in children whose diarrhoea was complicated by moderate dehydration. In those with mild dehydration lomotil had no advantage over kaolin. Children with severe dehydration treated with lomotil spent on the average much shorter period in hospital than those on kaolin, but the numbers were too small to allow for useful comparison. There was no adverse effect observed in any of subjects at the dose of lomotil used.
D000208:Acute Disease; D003681:Dehydration / Q000209:etiology; D003968:Diarrhea, Infantile / Q000150:complications / Q000188:drug therapy*; D004157:Diphenoxylate / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007223:Infant; D007540:Isonipecotic Acids / Q000627:therapeutic use*; D007616:Kaolin / Q000627:therapeutic use*; D008297:Male
D007540:Isonipecotic Acids; D007616:Kaolin; D004157:Diphenoxylate