Placental uptake and transfer of lipid in the postterm rabbit.
Gonadotropin-injected pregnant rabbits were delivered by cesarean section near term (30 days after conception (term, 31 days) and 3 1/2 and 4 days post term. Lipid metabolism of the postterm and near-term fetus was compared. Fetal and placental uptake of radioactivity and rate of lipid entry into the fetus, as well as fetal and maternal plasma free fatty acid (FFA) specific activities (at equilibrium) were determined following a single maternal injection of [1-14C]palmitate (50 muCi) administered at cesarean section. Evidence of placental malfunction in the postterm period includes decreased placental uptake and transport of labeled FFA occurring while maternal and fetal FFA dynamics (half times) remain unchanged and a loss in "organization": The strong positive correlation (p less than 0.001) between placental uptake and transfer to the fetus at 30 days' gestation is lost 5 days later. A comparison of maternal and fetal plasma FFA specific activities indicates a substantial (62%) near-term fetal contribution to its own circulating FFA pool. Total plasma FFA is elevated in the postterm fetus concomitant with a decreasing maternal supply. A postterm fetus must therefore contribute lipid from its own reserves (probably liver) in excess of amounts attributed to a near-term fetus, i.e., greater than 62%.
D000818:Animals; D001692:Biological Transport; D002250:Carbon Radioisotopes; D005260:Female; D005333:Fetus / Q000378:metabolism*; D006207:Half-Life; D007553:Isotope Labeling; D008099:Liver / Q000378:metabolism; D008431:Maternal-Fetal Exchange; D010169:Palmitic Acids / Q000097:blood / Q000378:metabolism*; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D011273:Pregnancy, Prolonged; D011817:Rabbits
D002250:Carbon Radioisotopes; D010169:Palmitic Acids