title: Bumetanide in heart failure in infancy.
abstract: The effect of bumetanide in infants with congenital heart disease presenting with cardiac failure was studied. The study was divided into acute (3 days) and long-term (mean 10.5 weeks) cases. A total of 12 male infants was included in the acute study and 13 cases were evaluated in the long-term study. The dose used in the acute study (0.015 mg/kg) was suboptimal; notwithstanding it was found to cause significant natriuresis and chloruresis. Bumetanide in doses varying in different infants from as little as 0.015 mg/kg on alternate days to as much as 0.10 mg/kg daily was shown to be an effective diuretic for long-term use. No side effects were observed in either study.
mesh_terms: D000208:Acute Disease; D002034:Bumetanide / Q000494:pharmacology / Q000627:therapeutic use*; D004231:Diuresis / Q000187:drug effects; D004232:Diuretics / Q000627:therapeutic use*; D006330:Heart Defects, Congenital / Q000188:drug therapy*; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008134:Long-Term Care; D008297:Male; D009994:Osmolar Concentration; D014556:Urine / Q000032:analysis
chemical_list: D004232:Diuretics; D002034:Bumetanide