Hyperplastic alveolar nodules of the rat mammary gland: tumor-producing capability in vivo and in vitro.
Carcinogen-induced hyperplastic alveolar nodules failed to form tumors after transplantation into isologous female rats; instead they developed ductal or ductal-alveolar outgrowths. Mammary glands from mid-pregnant female rats showed similar outgrowths following transplantation to the isologous hosts. In vitro and in vivo studies failed to demonstrate that subcarcinogenic doses of 7,12-dimethylbenz(a)anthracene can induce mammary tumorigenesis in the hyperplastic alveolar nodules. Our observations suggest that carcinogen-induced hyperplastic alveolar nodules are not 'preneoplastic' lesions in mammary carcinogenesis in the rat.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000008:administration & dosage; D000818:Animals; D005260:Female; D006965:Hyperplasia; D008321:Mammary Glands, Animal / Q000637:transplantation; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000209:etiology*; D009924:Organ Culture Techniques; D011230:Precancerous Conditions / Q000473:pathology; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D014185:Transplantation, Isogeneic
D015127:9,10-Dimethyl-1,2-benzanthracene