[Identification of hepatitis A antigen and antibody for the diagnosis of hepatitis A infection (author's transl)].
The maximal shedding of hepatitis A antigen (HA Ag) was found about one week before the appearance of icterus. In the first week after the appearance of jaundice, it was demonstrable in 57%, and in 22% in the second week. Since no persistent shedders of antigen have been found so far, in some cases a recent hepatitis A can be detected by identification of HA Ag in a stool sample obtained as soon as possible after the onset of the disease. The reliability of the investigation for antibodies against HA Ag (Anti-HAV) was tested with respect to 892 samples sent for diagnostic evaluation. Anti-HAV could be demonstrated regularly at the onset of the disease. It increased rapidly in the first two weeks after the appearance of jaundice.
D000208:Acute Disease; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis*; D000956:Antigens, Viral / Q000032:analysis*; D002648:Child; D005243:Feces / Q000032:analysis; D006506:Hepatitis A / Q000175:diagnosis*; D006801:Humans; D007118:Immunoassay / Q000379:methods; D007075:Immunoglobulin M; D007565:Jaundice / Q000097:blood; D008854:Microscopy, Electron; D011863:Radioimmunoassay / Q000379:methods; D013997:Time Factors
D000914:Antibodies, Viral; D000956:Antigens, Viral; D007075:Immunoglobulin M
Nachweis von Hepatitis-A-Antigen und -Antikörpern zur Diagnose der Hepatitis-A-Infektion.