[Acceleration of the speed of neuronal growth by a new neurotropic substance: N-isopropyl-amino-2-pyrimidine].
16 hrs. after per os administration of 14C N-isopropyl-amino-2-pyrimidine (IAP) in the Rat, radioactivity of the sciatic nerve is significantly higher than in plasma and other organs. In vitro IAP (base, orthophosphate or dichloracetate) accelerates neurite outgrowth of explained spinal ganglion after 48 hrs. of incubation in nutritive medium. Results suggest that IAP incorporated in nerve cell acts on cellular mechanisms controlling nerve growth.
D000818:Animals; D046508:Culture Techniques; D005727:Ganglia, Spinal / Q000254:growth & development*; D051379:Mice; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D011743:Pyrimidines / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats
D011743:Pyrimidines
Accélération de la vitesse de croissance du neruone par une nouvelle substance neurotrope: le N-isopropyl-amino-2-pyrimidine.