[Comparison of the effects of ethidium bromide and of the ethidium bromide-deoxyribonucleic acid complex in Ehrlich tumor cells].
When injected into the peritoneal cavity, ethidium bromide can strongly inhibit the multiplication of mouse Ehrlich ascites tumour cells. This antitumour effect is increased when ethidium bromide is linked to DNA and also injected into the peritoneal cavity. The cellular alterations are identical after a treatment with E.B. either free or bound to DNA. However, when the cells are treated with E.B.-DNA they contain E.B. for a longer period than after a treatment with E.B.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000473:pathology; D004247:DNA / Q000627:therapeutic use*; D004996:Ethidium / Q000031:analogs & derivatives / Q000378:metabolism / Q000627:therapeutic use*; D005260:Female; D051379:Mice; D008938:Mitosis / Q000187:drug effects; D013329:Structure-Activity Relationship
D004247:DNA; D004996:Ethidium
Comparaison des effets du bromure d'éthidium et du complexe bromure d'éthidium-acide désoxyribonucléique dans des cellules tumorales d'Ehrlich.