[Cytochemical analysis of nucleic acid and protein synthesis in fibroblasts treated in vitro by trimethoprim].
Chick embryo fibroblasts cultivated in vitro are treated with trimethoprim. The mitotic activity is strongly depressed. DNA and overall RNA and protein syntheses are inhibited. However, these effects are observed only when the concentration of the drug in the culture medium is relatively high.
D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts; D006651:Histocytochemistry; D008938:Mitosis / Q000187:drug effects; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis*; D014295:Trimethoprim / Q000494:pharmacology*
D012313:RNA; D004247:DNA; D014295:Trimethoprim
Analyse cytochimique des synthèses d'acides nucléiques et de protéines dans des fibroblastes traités in vitro par la triméthoprime