Human blood-group A- and H-specified glycosyltransferase levels in the sera of newborn infants and their mothers.
The level of blood-group A1-specified alpha,3'-N-acetyl-D-galactosaminyl-transferase in the serum of recently-delivered women was found to be appreciably lower than the level of this enzyme in the serum of non-pregnant adults and of newborn infants; a similar but less striking decrease was observed in the levels of the A2-specified alpha,3'-N-acetyl-D-galactosaminyltransferase and the H-specified alpha,2'-L-fucosyltransferase. Although the red cells of newborn infants are known to have relatively few A and H antigen sites, the serum of neonates was found to have a level of A1- and A2-dependent N-acetylgalactosaminyltransferases and H-dependent fucosyltransferase as high as, if not higher than, the serum of non-pregnant adults. This finding is compatible with the fact that the haemopoietic tissue contributes only about 20% of the serum transferase level.
D000017:ABO Blood-Group System; D005260:Female; D005312:Fetal Blood; D005646:Fucosyl Galactose alpha-N-Acetylgalactosaminyltransferase / Q000097:blood*; D005796:Genes; D006602:Hexosyltransferases / Q000097:blood*; D006801:Humans; D007231:Infant, Newborn; D007700:Kinetics; D008345:Manganese / Q000494:pharmacology; D010641:Phenotype; D011247:Pregnancy
D000017:ABO Blood-Group System; D008345:Manganese; D006602:Hexosyltransferases; D005646:Fucosyl Galactose alpha-N-Acetylgalactosaminyltransferase