title: Early detection of high risk subjects in affective disorders.
abstract: 1. Family, twin and linkage studies indicate that genetic factors are involved in the etiology of major affective disorders. 2. Recent clinical and biological research suggest that affective disorders are an heterogeneous group of illnesses, with variable genetic determination. 3. Since Lithium carbonate has been proven to be an effective prophylactic treatment in affective disorders, the question arises whether early detection of affective illness is possible and what are the implications for genetic counseling and primary prevention of affective illness.
mesh_terms: D001714:Bipolar Disorder / Q000235:genetics / Q000523:psychology; D004200:Diseases in Twins; D004777:Environment; D005260:Female; D006801:Humans; D008094:Lithium / Q000627:therapeutic use; D008297:Male; D019964:Mood Disorders / Q000175:diagnosis* / Q000188:drug therapy / Q000517:prevention & control / Q000523:psychology; D012307:Risk Factors
chemical_list: D008094:Lithium