title: Loss of the Y chromosome from bone marrow cells of males with myeloproliferative disorders. Report of two cases and review of the literature.
abstract: Two additional cases of myeloproliferative disorders are described showing as the only chromosome abnormality a loss of the Y chromosome. Comparing these cases with cases reviewed from the literature indicates that a loss of the Y chromosome in Ph1-positive and Ph1-negative CML may cause only a somewhat longer life expectancy following diagnosis. The exact role of the Y chromosome, however, in the initiation or progression of a malignant disorder cannot be stated at this time.
mesh_terms: D000328:Adult; D000368:Aged; D001853:Bone Marrow / Q000648:ultrastructure*; D001854:Bone Marrow Cells; D002675:Child, Preschool; D002869:Chromosome Aberrations; D002904:Chromosomes, Human, 21-22 and Y; D006801:Humans; D007951:Leukemia, Myeloid / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012730:Sex Chromosomes