Effects of Cannabis sativa on ultrastructure of the synapse in monkey brain.
Electron microscopic study of brain tissues of monkeys chronically exposed to psychoactive Cannabis showed widening of the synaptic cleft, electron opaque material in the cleft and in pre- and postsynaptic regions, and some "clumping" of synaptic vesicles. In contrast, tissues of control monkeys showed no ultrastructural changes.
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000648:ultrastructure; D013759:Dronabinol / Q000008:administration & dosage / Q000633:toxicity*; D000882:Haplorhini; D007275:Injections, Intravenous; D008854:Microscopy, Electron; D013569:Synapses / Q000187:drug effects* / Q000648:ultrastructure
D013759:Dronabinol