title: Unconjugated estriol and 15alpha-hydroxyestriol in complicated pregnancies.
abstract: Simultaneous determinations of unconjugated estriol and 15alpha-hydroxyestriol (E4) levels in maternal serum were studied serially to ascertain the relative usefulness of these estrogens as indicators of fetal welfare. Complicated pregnancies included 16 patients with pre-eclampsia and/or hypertension, six patients with severe Rh-isoimmunization, 12 patients with diabetes mellitus, of which four had vascular disease, three patients with fetal death in utero, and three twin pregnancies. Retrospective analysis failed to indicate a clinically useful role for serum E4 determinations in the evaluation of fetal welfare during high-risk pregnancies.
mesh_terms: D000917:Antibody Formation; D002849:Chromatography, Gas; D002853:Chromatography, Liquid; D002940:Circadian Rhythm; D003925:Diabetic Angiopathies / Q000276:immunology / Q000378:metabolism; D004964:Estriol / Q000031:analogs & derivatives* / Q000378:metabolism*; D005260:Female; D005313:Fetal Death / Q000276:immunology / Q000378:metabolism; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology / Q000378:metabolism*; D011254:Pregnancy in Diabetics / Q000276:immunology / Q000378:metabolism; D011272:Pregnancy, Multiple; D012204:Rh-Hr Blood-Group System; D014427:Twins
chemical_list: D012204:Rh-Hr Blood-Group System; D004964:Estriol