[The efficacy of praziquantel against experimental cysticercosis and hydatidosis (author's transl)].
Praziquantel is active against cysticerci in experimentally infected mice, rabbits, sheep and cattle. After single or repeated application the infectious stages of Hymenolepis nana, Cysticercus fasciolaris, C. pisiformis, C. tennuicollis and C. bovis were killed. The compound is more active against older than against younger stages as demonstrated with H. nana-cystecercoids and C. fasciolaris in mice. Against the tetrahyridia of Mesocestoides corti in mice praziquantel is only effective after an intraperitoneal application of an oily suspension. Praziquantel shows also activity in rodents against the infectious protoscolices of Echinococcus multilocularis but failed to inhibit the growth of the hydatid cysts.
D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000627:therapeutic use*; D002417:Cattle; D003551:Cysticercosis / Q000188:drug therapy*; D004285:Dogs; D004341:Drug Evaluation; D004443:Echinococcosis / Q000188:drug therapy*; D000882:Haplorhini; D007546:Isoquinolines / Q000008:administration & dosage / Q000627:therapeutic use*; D051379:Mice; D011719:Pyrazines / Q000008:administration & dosage / Q000627:therapeutic use; D051381:Rats; D012756:Sheep
D000871:Anthelmintics; D007546:Isoquinolines; D011719:Pyrazines
Zur Wirksamkeit von Praziquantel bei der experimentellen Cysticercose und Hydatidose.