Extended survival of pancreatic islet allografts in the testis of guinea-pigs.
1. Pancreatic islets, isolated from the guinea-pig pancreas by microdissection and transplanted as allografts to the testis, may survive for 11 weeks, some 5 times the maximum survival of orthotopic skin grafts. 2. Intratesticular islet cell allografts appear not to provoke a systemic immunity such as might be detected by the behaviour of a subsequent orthotopic skin allograft from the same donor. 3. Intratesticular islet cell allografts succumb (in 'second set' fashion) to a pre-existing immunity generated by a prior orthotopic skin allograft. 4. Further experimental work is necessary to determine the relative importance of graft dosage, graft antigenicity, graft site and 'graft adaptation' in determining this extended survival.
D000818:Animals; D006085:Graft Survival; D006168:Guinea Pigs; D016381:Islets of Langerhans Transplantation; D008297:Male; D016038:Skin Transplantation; D013737:Testis / Q000601:surgery*; D013997:Time Factors; D014181:Transplantation Immunology; D014184:Transplantation, Homologous