Forssman glycolipid variants of dog gastric mucosa. Structure of a branched ceramide octasaccharide.
A fucose-containing ceramide octasaccharide exhibiting Forssman antigenic activity, and reacting in human H anti-H and anti-A systems, was isolated from water-soluble glycolipids of dog gastric mucosa. Defucosylation of the glycolipid resulted in the loss of H-activity, but had no effect on its Forssman nor blood-group A antigenic activity. The branched structure of glycolipid was identified by partial acid hydrolysis, sequential degradation with specific glycosidases and comparison of the permethylation products of the native and enzyme-degraded compound. The structure of this glycolipid is proposed to be: formula.
D000818:Animals; D002241:Carbohydrates / Q000032:analysis; D002518:Ceramides; D004285:Dogs; D005577:Forssman Antigen; D005643:Fucose / Q000032:analysis; D005753:Gastric Mucosa / Q000276:immunology*; D006017:Glycolipids / Q000276:immunology; D006386:Hemagglutination Tests; D005779:Immunodiffusion; D008968:Molecular Conformation
D002241:Carbohydrates; D002518:Ceramides; D006017:Glycolipids; D005643:Fucose; D005577:Forssman Antigen