Intravenous thyrotropin releasing hormone (TRH) enhances the excitatory actions of acetylcholine (ACh) on rat cortical neurons.
I.v. administered TRH (1.25--10 mg/kg) enhanced the excitatory actions of iontophoretically applied ACh on spontaneously active cerebral cortical neurons of pentobarbital-anaesthetized rats. These observations are consistent with the hypothesis of a cholinergic-link in the anti-anaesthetic actions of exogenously administered TRH.
D000109:Acetylcholine / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects*; D004357:Drug Synergism; D005260:Female; D007275:Injections, Intravenous; D007478:Iontophoresis; D009474:Neurons / Q000187:drug effects*; D010424:Pentobarbital; D051381:Rats; D013973:Thyrotropin-Releasing Hormone / Q000008:administration & dosage / Q000494:pharmacology*
D013973:Thyrotropin-Releasing Hormone; D010424:Pentobarbital; D000109:Acetylcholine