GABA involvement in memory consolidation: evidence from posttrial amino-oxyacetic acid.
In order to assess the possible effects of central GABA activation on the consolidation of shock avoidance, the GABA-T inhibitor amino-oxyacetic acid (AOAA) was administered posttrial to adult male rats. Learning was assessed over nine widely spaced sessions of 20 trials each. AOAA-treated animals showed learning within sessions and a lack of consolidation across sessions. Controls, on the other hand, showed learning both within and across sessions. This evidence agrees with previous reports suggesting GABA involvement in memory processes.
D000085:Acetates / Q000494:pharmacology*; D000613:Aminobutyrates / Q000502:physiology*; D000625:Aminooxyacetic Acid / Q000494:pharmacology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D004597:Electroshock; D008297:Male; D008568:Memory / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D000085:Acetates; D000613:Aminobutyrates; D000625:Aminooxyacetic Acid; D005680:gamma-Aminobutyric Acid