Cytoenzymologic activities of some oxidreductases in thyreopathies.
The authors studied in cryostat sections and in smears from thyroid aspirates the cytoenzymic pattern of the following thyreopathies: euthyroid goitre, GRAVES' disease, hyperthyroidized goitre, HASHIMOTO's thyroiditis and folliculo-papillary carcinoma. A biochemical study was simultaneously performed. According to the investigated thyreopathies the highest enzymic activity was found in the GRAVES' disease especially for peroxidase, glucose-6-phosphate dehydrogenase and succinate dehydrogenase. Lactate dehydrogenase showed a great activity in thyroid cancer. The lowest activity was found in the HASHIMOTO's thyroiditis with strong fibrosclerosis. The same pattern was found in thyroid smears from fine needle aspirates. The biochemical analysi revealed a strong parallelism with cytoenzymic results. The isozymic pattern of lactate dehydrogenase showed no significant differences between the thyreopathies.
D005260:Female; D006801:Humans; D008297:Male; D010088:Oxidoreductases / Q000378:metabolism*; D013959:Thyroid Diseases / Q000201:enzymology*; D013961:Thyroid Gland / Q000201:enzymology
D010088:Oxidoreductases