Studies on pyrazine derivatives. Part XIII. synthesis and tuberculostatic activity of some 6-alkyl-amino- and 6-dialkylhydrazinopyrazine-2-carboxylic acids derivatives.
6-RNH- and 6-R2NNH-pyrazine-2-carbothioamides 1--3, 5, 6, 9 and 14 were obtained from 2-cyano-6-chloropyrazine. In the in vitro screening the thioamides were active against Myc. tuber. H37Rv at the conc. range of 15.6--250 microgram/cm3. The most active thioamides 1 and 8, however, do not act in experimental tuberculosis in guinea pigs.
D000588:Amines / Q000627:therapeutic use; D000818:Animals; D002626:Chemistry, Pharmaceutical; D006834:Hydrazines / Q000627:therapeutic use; D051379:Mice; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D011719:Pyrazines / Q000627:therapeutic use*; D014376:Tuberculosis / Q000188:drug therapy*
D000588:Amines; D006834:Hydrazines; D011719:Pyrazines