title: Cryofibrinogenemia, monoclonal gammopathy, and purpura. Report of a case and review of the literature.
abstract: A patient with purpura, acral blisters, and ulcerations was evaluated and found to have cryofibrinogenemia and an IgG K light chain monoclonal gammopathy. No other systemic illness was found. The overall incidence of significant cryofibrinogenemia include neoplastic, thrombotic, infectious, and miscellaneous disorders. The patient described was not easily classified. This case is probably best considered primary or idiopathic cryofibrinogenemia.
mesh_terms: D000328:Adult; D003080:Cold Temperature; D005340:Fibrinogen; D005533:Foot Dermatoses / Q000209:etiology; D006801:Humans; D006942:Hypergammaglobulinemia / Q000473:pathology*; D007868:Leg Dermatoses / Q000209:etiology; D008297:Male; D011694:Purpura, Hyperglobulinemic / Q000473:pathology*; D012867:Skin / Q000473:pathology*; D012883:Skin Ulcer / Q000209:etiology
chemical_list: D005340:Fibrinogen