[Effect of methotrexate on glycolysis of leukemia L 1210 cells cultivated in vitro].
Methotrexate, at non lethal doses, alters the glycolysis of leukaemic L 1210 cells. Glucose uptake and lactate excretion are increased but lactate/glucose ratio remains constant. The activity of glycolytic enzymes in the cytoplasm is increased and the level of intracellular ATP is greatly enhanced.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D005947:Glucose / Q000378:metabolism; D006019:Glycolysis / Q000187:drug effects*; D007773:Lactates / Q000378:metabolism; D007939:Leukemia L1210 / Q000378:metabolism*; D008727:Methotrexate / Q000494:pharmacology*
D007773:Lactates; D000255:Adenosine Triphosphate; D005947:Glucose; D008727:Methotrexate
Action du méthotrexate sur la glycolyse des cellules leucémiques L 1210 cultivées in vitro.