[Antitumor effects of keto-nucleosides. Study of the antitumor activity of y(3'-O-acetyl-4', 6'-dideoxy-beta-L-glycero-hex-3'-eno-pyranosyl) theophylline and 1(4'-keto-2'-3'-O-isopropylidene-alpha-L-''rhamnosyl''O thymine against L 1210 leukemia in mice].
The effects of two keto-nucleosides on survival time of Mice with i.p. L 1210 leukemia were studied. The purine unsaturated keto-nucleoside was shown to be much more active than the pyrimidine keto-nucleoside.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D007939:Leukemia L1210 / Q000188:drug therapy*; D051379:Mice; D009705:Nucleosides / Q000627:therapeutic use* / Q000633:toxicity; D013329:Structure-Activity Relationship; D013806:Theophylline / Q000031:analogs & derivatives / Q000627:therapeutic use; D013941:Thymine / Q000031:analogs & derivatives
D009705:Nucleosides; D013806:Theophylline; D013941:Thymine
Effet antitumoral de céto-nucléosides. Etude de l'action de (O-acétyl-3' didésoxy-4'. 6'-beta-L-glycéro-hexene-3'-pyrannosulosyl)-7 théophylline et de la (O-isopropylidène-2'. 3'-alpha-L-lyxo-hexopyrannosulos-4'-yl)-1 thymine sur la leucémie L 1210 de la souris.