Role of 5-hydroxytryptamine in the vasoconstrictor action of compound 48/80 in the rat femoral vasculature.
1. The effect of compound 48/80 on the rat femoral vasculature was examined by means of a cross-circulation technique. 2. Intra-arterial injection of increasing doses (1.5 to 15 microgram) of compound 48/80 caused dose-dependent vasoconstriction preceded by transient vasodilatation. The vasoconstriction was significantly reduced in reserpine-treated preparations and converted to vasodilatation by methysergide. 3. When the vasoconstrictor response to a large dose (300 microgram) of adenosine was abolished by repeated administration, the response to compound 48/80 remained unaltered. 4. The present results indicate that the femoral arterial vasoconstriction by compound 48/80 in the rat is mediated by the release of 5-hydroxytryptamine (5-HT); this 5-HT may be liberated from a different storage site from that released by adenosine.
D000241:Adenosine / Q000494:pharmacology; D000818:Animals; D005269:Femur / Q000098:blood supply; D006614:Hindlimb / Q000098:blood supply; D066298:In Vitro Techniques; D008297:Male; D008784:Methysergide / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D012039:Regional Blood Flow / Q000187:drug effects; D012110:Reserpine / Q000494:pharmacology; D012701:Serotonin / Q000502:physiology*; D013997:Time Factors; D014439:Tyramine / Q000494:pharmacology; D014662:Vasoconstrictor Agents; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology*
D014662:Vasoconstrictor Agents; D012701:Serotonin; D003189:p-Methoxy-N-methylphenethylamine; D012110:Reserpine; D000241:Adenosine; D009638:Norepinephrine; D014439:Tyramine; D008784:Methysergide