Effects of endogenous prostaglandin E on intestinal motility.
The role of endogenous prostaglandin E (PGE) in the regulation of intestinal motility in situ was studied in cats anesthetized with pentobarbital. The basal concentration of PGE in the ileum was found by radioimmunoassay to be 3.3 +/- 0.6 ng PGE per g wet wt (chi +/- SE, n = 12). Intramesenteric arterial infusion of acetylcholine (ACh) (100 microgram/min) increased intestinal motility, and PGE concentration rose to 6.7 +/- 0.8 ng/g. Intravenous infusion of indomethacin (4 mg/kg) enhanced spontaneous and ACh-induced motility and abolished the ACh-induced rise in ileal PGE concentration. We conclude that basal PGE synthesis limits the motility of the resting and ACh-stimulated cat ileum.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D016861:Cyclooxygenase Inhibitors; D004347:Drug Interactions; D005769:Gastrointestinal Motility / Q000187:drug effects; D007082:Ileum / Q000378:metabolism; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D008638:Mesenteric Arteries / Q000187:drug effects; D011458:Prostaglandins E / Q000378:metabolism / Q000502:physiology*; D012039:Regional Blood Flow / Q000187:drug effects
D016861:Cyclooxygenase Inhibitors; D011458:Prostaglandins E; D000109:Acetylcholine; D007213:Indomethacin