Hemiparkinsonism. A human model for studying dopaminergic supersensitivity.
The observation of a patient suffering from a parkinsonian syndrome, almost entirely expressed on the right side, and "on-off" attacks with rotatory movement of the trunk, led us to consider that the rotational model of animals may be reproduced in man. The symptoms presented by our patient may reflect a predominant degeneration in the nigrostriatal pathway of the left side. We suggest that his torsion behavior is due to hypersensitivity phenomenon of the dopaminergic receptors on this side.
D000818:Animals; D000978:Antiparkinson Agents / Q000627:therapeutic use*; D001971:Bromocriptine / Q000627:therapeutic use; D002230:Carbidopa / Q000627:therapeutic use; D003913:Dextroamphetamine / Q000627:therapeutic use; D004195:Disease Models, Animal; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009068:Movement; D010302:Parkinson Disease, Secondary / Q000175:diagnosis / Q000188:drug therapy* / Q000378:metabolism; D011954:Receptors, Dopamine / Q000187:drug effects*
D000978:Antiparkinson Agents; D011954:Receptors, Dopamine; D001971:Bromocriptine; D007980:Levodopa; D002230:Carbidopa; D003913:Dextroamphetamine