[Effectiveness of terrilytin in the treatment of experimental pulmonary vascular thrombosis].
The thrombolytic effect of Aspergillus terricola proteinase terrilytin was studied in 24-hour experimental pulmonary vascular thrombosis of rabbits. The drug was dissolved in polyvinylpyrrolidon and injected into the blood flow in doses of 175 and 220 PU/kg by two routes: locally (into the thrombosed vessel) and systemically. The drug produced a high thrombolytic effect irrespective of the administration and dosage; however, the effect was more marked in local infusion of terrilytin in a dose of 220 PU/kg. No side effects were observed.
D000681:Amylases; D000818:Animals; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D005343:Fibrinolytic Agents; D006439:Hemodynamics / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects; D010447:Peptide Hydrolases / Q000627:therapeutic use*; D011652:Pulmonary Circulation / Q000187:drug effects; D011655:Pulmonary Embolism / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology; D011817:Rabbits
D004338:Drug Combinations; D005343:Fibrinolytic Agents; C009402:amylase, phosphates, proteases drug combinations; D000681:Amylases; D010447:Peptide Hydrolases
Ob éffektivnosti terrilitina pri lechenii tromboza legochnykh sosudov v éksperimente.