Typhoid: clinical picture and response to chloramphenicol. Prospective study in Bombay (1972).
The clinical picture of 78 cases with proven typhoid and 18 cases with proven paratyphoid A fever is presented. The diagnosis was made by isolating the organisms from the blood. The Widal test could not be used as a diagnostic criterion. By means of chemotherapy with chloramphenicol (initial dose 30-40 mg/kg body weight) defervescence was achieved within an average of 4.5 days. The course of the disease was generally mild; one patient with typhoid fever died. The average hospital stay was 19 days. Four patients of the typhoid fever group were readmitted with a relapse. The laboratory examinations included blood clot culture, phage typing, Widal test, haemoglobin, leucocyte count, transaminases, serum bilirubin, and routine examination and culture of stool and urine. Forty-two patients were infected with intestinal parasites and 25 with Shigella organism. The findings are discussed and compared with findings of similar studies of enteric fever.
D000293:Adolescent; D000328:Adult; D002648:Child; D002701:Chloramphenicol / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D010284:Paratyphoid Fever / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D011446:Prospective Studies; D014435:Typhoid Fever / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy
D002701:Chloramphenicol