[Effect of benzatropine on the O-methylation of striatal dopamine].
After treatment by nialamid, benztropine administered to Rats produced an increase in the level of 3-O-methyldopamine in the corpus striatum. It produced a slight increase in the level of striatal dopamine and no change in the level of norepinephrine. The monoamine oxydase and catechol-O-methyltransferase activities of remaining brain showed no variations by benztropine. The results suggest the possible involvement of striatal dopamine and its extraneuronally catabolism in the antiparkinsonian effect of benztropine.
D000818:Animals; D001590:Benztropine / Q000494:pharmacology*; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D003846:Deoxyepinephrine / Q000096:biosynthesis; D004298:Dopamine / Q000378:metabolism*; D008297:Male; D008745:Methylation; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D014326:Tropanes / Q000494:pharmacology*
D008996:Monoamine Oxidase Inhibitors; D014326:Tropanes; D001590:Benztropine; D003846:Deoxyepinephrine; D004298:Dopamine; D009638:Norepinephrine
Action de la benzatropine sur la O-méthylation de la dopamine striatale