title: Cytotoxic T-cell responses to H-Y: correlation with the rejection of syngeneic male skin grafts.
abstract: The ability of female mice to rapidly reject syngenic male skin grafts is largely determined by dominant genes in the IB region of the H-2b halotype, whereas the ability to produce anti-H-Y cytotoxic cells is determined by a dominant gene in the IA region the H-2b halotype, or by complementary genes in the IC region of some other haplotypes. Thus, it seems that H-2-retricted anti-H-Y cytotoxic T cells are not responsible for the rejection of syngeneic male skin grafts.
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D003602:Cytotoxicity, Immunologic; D005260:Female; D005799:Genes, Dominant; D005802:Genes, MHC Class II; D006084:Graft Rejection; D006183:H-2 Antigens / Q000235:genetics; D006649:Histocompatibility Antigens / Q000235:genetics*; D006824:Hybridization, Genetic; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D016038:Skin Transplantation; D013601:T-Lymphocytes / Q000276:immunology; D014184:Transplantation, Homologous; D014998:Y Chromosome
chemical_list: D006183:H-2 Antigens; D006649:Histocompatibility Antigens