title: A review of the renin-angiotensin system: historical and methodological perspectives.
abstract: It is apparent that early studies of the renin-AII system utilized measurement of blood pressure and organ bath techniques. More recent methods of electrophoresis, RIA and binding studies are continuing to add to our knowledge. Future studies will involve receptor isolation and understanding of the post-receptor mechanism of transduction of the AII response. With the recent advances in our knowledge of peptide hormone-receptor interaction, particularly new findings that peptide hormones can enter the cell, it is apparent that intracellular actions of AII will provide a new field of discovery.
mesh_terms: D000804:Angiotensin II / Q000037:antagonists & inhibitors / Q000266:history / Q000494:pharmacology / Q000502:physiology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects; D006321:Heart / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D049673:History, 20th Century; D006801:Humans; D007477:Ions / Q000378:metabolism; D009130:Muscle, Smooth / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D009994:Osmolar Concentration; D012083:Renin / Q000266:history / Q000502:physiology*
chemical_list: D007477:Ions; D000804:Angiotensin II; D012083:Renin