[Immunologic factors and platelet vessel wall interactions (author's transl)].
Platelet subendothelium interaction is an essential step in thrombosis and hemostasis which can be modulated by immunoglobulins, immune complexes, complement, and leukocytes. Antiplatelet antibodies can induce thrombocytopenia which is accompanied by a reduced vascular wall thickness and an increased fenestration. Antigen-antibody complexes can activate platelets inducing platelet release and aggregation. This reaction is amplified by the first component of complement C1q. Cytotoxic antibodies directed against endothelial cells have been observed in transplantation. These antibodies can be directed against HL-A antigens or specific endothelial antigens. Anticollagen antibodies have been detected in patients with leprosy. The C1q component can inhibit adhesion of platelets to collagen and platelet aggregation induced by collagen. The association of acquired or congenital C1q deficiency and vasculitis has been reported. C3a is taken up by endothelial cells and metabolized. C3a and C5a can modify vessel wall permeability and activate granulocytes which can become toxic for endothelial cells. Leukocyte cationic protein can reduce platelet aggregation. An anti-von Willebrand antibody could be the origin of hemostatic abnormalities and endothelial lesions. The involvement of immunologic factors in platelet vessel wall interactions is complex. Immune complexes and some antibodies seem capable of promoting thrombosis, while a component of complement (C1q) may also have an antithrombotic role.
D000906:Antibodies; D000936:Antigen-Antibody Complex; D001779:Blood Coagulation Factors / Q000276:immunology; D001792:Blood Platelets / Q000276:immunology*; D001808:Blood Vessels / Q000276:immunology*; D002450:Cell Communication; D003165:Complement System Proteins / Q000276:immunology; D004727:Endothelium / Q000166:cytology / Q000276:immunology; D006801:Humans; D007962:Leukocytes / Q000276:immunology
D000906:Antibodies; D000936:Antigen-Antibody Complex; D001779:Blood Coagulation Factors; D003165:Complement System Proteins
Facteurs immunologiques et interactions entre plaquettes et paroi vasculaire.