The effect of mannitol infusion on retinal function and oxygen tension.
Mannitol administered intravenously in rhesus monkeys resulted in a temporary recovery of the visual evoked response (VER) after its decrease due to elevation of the intraocular pressure. Mannitol infusion caused an immediate, albeit transitory, increase in retinal oxygen tension. These changes were independent of the ocular hypotensive effect of mannitol, and we conclude that the drug is a far better agent for the treatment of acute glaucoma than heretofore believed.
D000818:Animals; D002339:Carotid Arteries / Q000502:physiology; D005071:Evoked Potentials / Q000187:drug effects; D005901:Glaucoma / Q000188:drug therapy; D000882:Haplorhini; D007263:Infusions, Parenteral; D008253:Macaca mulatta; D008353:Mannitol / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D010100:Oxygen; D010313:Partial Pressure; D012039:Regional Blood Flow / Q000187:drug effects; D012160:Retina / Q000187:drug effects / Q000502:physiology*; D014793:Visual Cortex / Q000502:physiology
D008353:Mannitol; D010100:Oxygen