A comparative trial of the anthelminthic efficacy of pyrantel pamoate (Combantrin) and thiabendazole (Mintezol).
The anthelminthic efficacy of pyrantel pamoate (Combantrin) in a single dose of 10 mg/kg body weight was compared with that of thiabendazole (Mintezol) in two doses each of 25 mg/kg body weight in a controlled trial. Follow-up examination, 6 weeks after treatment with Combantrin gave cure rates of 93.8%, and 29.1% for infection with Ascaris and the Hookworm respectively, and 44.3% and 27.3% in those treated with Mintezol. The reduction in hookworm egg counts was higher in patients treated with Combantrin than with Mintezol, and Combantrin was better tolerated. Neither drug was effective against the Trichuris. The results are compared with those from other parts of the world.
D000293:Adolescent; D001196:Ascariasis / Q000188:drug therapy; D002648:Child; D006725:Hookworm Infections / Q000188:drug therapy; D006801:Humans; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy; D011715:Pyrantel / Q000031:analogs & derivatives*; D011716:Pyrantel Pamoate / Q000627:therapeutic use*; D013322:Strongyloidiasis / Q000188:drug therapy; D013827:Thiabendazole / Q000627:therapeutic use*; D014257:Trichuriasis / Q000188:drug therapy
D011715:Pyrantel; D011716:Pyrantel Pamoate; D013827:Thiabendazole