title: Maternal anticonvulsants and optic nerve hypoplasia.
abstract: Seven patients with optic nerve hypoplasia, born of epileptic mothers, are presented. All the mothers took anticonvulsants during pregnancy. The possibility that maternal anticonvulsant therapy may play a role in the genesis of optic nerve hypoplasia is discussed in the light of what is known about the teratogenicity of these agents.
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D002648:Child; D002675:Child, Preschool; D004830:Epilepsy, Tonic-Clonic / Q000188:drug therapy; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009900:Optic Nerve / Q000002:abnormalities*; D010672:Phenytoin / Q000009:adverse effects* / Q000627:therapeutic use; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy; D014786:Vision Disorders / Q000209:etiology
chemical_list: D010672:Phenytoin