[Characteristics of the interaction of 9,10-dimethyl-1,2-benzanthracene with the hairy cells in the central nervous system].
The implantation of a pill containing carcinogen DMBA into the right hemisphere of the rat brain induces the formation of a capsule, the innermost layer of which is composed of "hairy" cells. Two principally different mechanisms of carcinogen penetration into the "hairy" cell were distinguished: ordinary phagocytosis and biochemical interaction of carcinogen with the cell membrane. It is supposed that in the second case there occurs formation of secondary carcinogenic products in the form of steroid hormone which could be morphologically identified as lipid-like structures of the "hairy" cell.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D001551:Benz(a)Anthracenes / Q000494:pharmacology*; D002273:Carcinogens; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D002490:Central Nervous System / Q000166:cytology* / Q000187:drug effects; D003593:Cytoplasm / Q000187:drug effects; D005260:Female; D010587:Phagocytosis / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013256:Steroids / Q000096:biosynthesis; D013997:Time Factors
D001551:Benz(a)Anthracenes; D002273:Carcinogens; D013256:Steroids; D015127:9,10-Dimethyl-1,2-benzanthracene
Nekotorye osobennosti vzaimodeĭstviia 9,10-dimetil, 1,2-benzantratsena s vorsinchatymi kletkami v tsentral' noĭ nervnoĭ sisteme.