Acceleration of plasma bicarbonate conversion to carbon dioxide by pulmonary carbonic anhydrase.
In isolated rabbit lungs perfused with solutions containing little or no carbonic anhydrase activity, nearly complete equilibration between H14CO3- and 14CO2 occurs during a single circulation. This equilibration can be inhibited by blocking pulmonary carbonic anhydrase with acetazolamide.
D000086:Acetazolamide / Q000494:pharmacology; D000818:Animals; D001639:Bicarbonates / Q000097:blood* / Q000378:metabolism; D002245:Carbon Dioxide / Q000097:blood*; D002256:Carbonic Anhydrases / Q000378:metabolism*; D008168:Lung / Q000201:enzymology* / Q000378:metabolism; D010477:Perfusion; D011817:Rabbits
D001639:Bicarbonates; D002245:Carbon Dioxide; D002256:Carbonic Anhydrases; D000086:Acetazolamide