[Effect of the respiratory chain redox state on mitochondrial membrane permeability for K+ ions].
Transport of Pi into mitochondrial matrix induces K+-permeability of the membranes, which results from the addition of DNP. This induction of K+ efflux is eliminated by some agents causing the respiratory chain reduction (e.g. succinate, rotenone, antimycin A). It was shown that the abolition of the membrane potential is not sufficient for K+ efflux induction. The latter process is necessary for the energy-linked formation of the K+-transporting system. The lipid fraction containing lecithin and monophosphoinositol was extracted from the mitochondria after preincubation with Pi. The artificial bilayer membranes formed from these lipids are permeable for K+.
D000818:Animals; D007425:Intracellular Membranes / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D008563:Membrane Lipids / Q000502:physiology; D008930:Mitochondria, Liver / Q000378:metabolism*; D010084:Oxidation-Reduction; D010101:Oxygen Consumption; D010539:Permeability; D010710:Phosphates / Q000494:pharmacology; D010743:Phospholipids / Q000502:physiology; D011188:Potassium / Q000378:metabolism*; D051381:Rats
D008563:Membrane Lipids; D010710:Phosphates; D010743:Phospholipids; D011188:Potassium
Vliianie redoks-sostoianiia dykhatel'noĭ tsepi na pronitsaemost' membrany mitokhondriĭ dlia ionov kaliia.