Volatile N-nitrosamines in the urine of normal donors and of bladder cancer patients.
Volatile N-nitrosamines were detected in the urine of male volunteers with gas-liquid and high-pressure liquid chromatography interfaced to the thermal energy analyzer. Of 50 samples from normal males, 10 contained nitrosodimethylamine (0.02 to 0.10 micrograms/liter), 6 contained nitrosodiethylamine (0.02 to 3.10), 9 contained nitrosomorpholine (0.006 to 0.67), and none contained nitrosodibutylamine. Of 4 samples from bladder cancer patients, 2 contained nitrosodibutylamine (0.35 and 0.66). Cigarette smoking did not appear to be related to the pattern or amount of urinary volatile N-nitrosamines. The possibility that the N-nitrosamines arise from the diet or from endogenous production is considered.
D000328:Adult; D000368:Aged; D002851:Chromatography, High Pressure Liquid; D004052:Diethylnitrosamine / Q000378:metabolism; D004128:Dimethylnitrosamine / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009602:Nitrosamines / Q000032:analysis / Q000378:metabolism*; D012907:Smoking / Q000503:physiopathology; D001749:Urinary Bladder Neoplasms / Q000652:urine*
D009602:Nitrosamines; D004052:Diethylnitrosamine; D004128:Dimethylnitrosamine