[Endocrine sequela of radiation treatment of extracranial head and neck tumors].
A study of the thyroid and hypothalamo-pituitary functions was undertaken in 14 children having been irradiated for tumors of the neck and head. The following anomalies were found: S.T.H. deficiency: 8 cases, A.C.T.H. deficiency: 2 cases, T.S.H. deficiency: 4 cases, primary thyroid insufficiency: 4 cases. Growth was severely impaired since the height of 10 out of 14 patients was less than or equal to 2 S.D. These results emphasize the frequency of endocrine lesions related to radiotherapy, as the lesions were essentially extracranial. They also show a repercussion on growth, which worsen the long-term prognosis of these diseases.
D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000172:deficiency; D002648:Child; D002675:Child, Preschool; D005260:Female; D013006:Growth Hormone / Q000172:deficiency; D006258:Head and Neck Neoplasms / Q000532:radiotherapy*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology / Q000528:radiation effects*; D007049:Iatrogenic Disease / Q000209:etiology; D007223:Infant; D008297:Male; D011882:Radiotherapy, High-Energy / Q000009:adverse effects; D013959:Thyroid Diseases / Q000209:etiology; D013961:Thyroid Gland / Q000503:physiopathology / Q000528:radiation effects*; D013972:Thyrotropin / Q000172:deficiency
D000305:Adrenal Cortex Hormones; D013972:Thyrotropin; D013006:Growth Hormone
Sequelles endocriniennes des irradiations de la tete et du cou pour tumeurs extracraniennes.