Long-term treatment of onchocerciasis in children with low doses of diethylcarbamazine.
Two groups of children were treated daily with 12.5 or 25 mg diethylcarbamazine for five months and a further group with 12.5 mg daily for seven weeks; 88 children completed the course. The trial was under constant supervision and ophthalmic and parasitological examinations were carried out at approximately one-month intervals. The acceptability of the drug was poor owing to adverse reactions, but the clinical response to treatment good.
D002648:Child; D002986:Clinical Trials as Topic; D003318:Corneal Opacity / Q000473:pathology; D004049:Diethylcarbamazine / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D005123:Eye / Q000469:parasitology; D005869:Ghana; D006801:Humans; D008134:Long-Term Care; D009855:Onchocerciasis / Q000188:drug therapy*; D012867:Skin / Q000469:parasitology; D014792:Visual Acuity
D004049:Diethylcarbamazine