Mitogenic effect in mouse liver induced by a hypolipidemic drug, nafenopin.
The mitogenic effect of Nafenopin, a hypolipidemic hepatic peroxisome proliferator, in mouse liver has been studied in acute and chronically treated mice. After 1, 6 and 32 weeks of treatment, the total hepatic DNA was increased 1.5-2.0-fold over controls. Mitotic and labeling indices were also increased 3-4 fold after 5 days, 6 weeks and 32 weeks of treatment. The increased mitotic activity in nafenopin fed animals was not associated with liver cell necrosis. The nafenopin induced hepatomegaly therefore appears to arise from a combination of cell proliferation, as well as, cellular hypertrophy, which is associated with peroxisome proliferation.
D000818:Animals; D006965:Hyperplasia; D006984:Hypertrophy; D008099:Liver / Q000187:drug effects* / Q000648:ultrastructure; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008830:Microbodies / Q000187:drug effects; D008934:Mitogens; D009255:Nafenopin / Q000494:pharmacology*; D011422:Propionates / Q000494:pharmacology*
D008934:Mitogens; D011422:Propionates; D009255:Nafenopin