Further evaluation of the effect of estrogen on tumor-associated immunity in prostatic cancer.
Reactivity of leukocytes to allogeneic extracts of malignant prostate from patients with prostatic cancer, as evaluated by antigen-induced leukocyte-adherence inhibtion, was significantly suppressed in the presence of diethylstilbestrol diphosphate. The observed suppression of tumor-associated immunity in the presence of exogenous estrogen provides further evidence supporting earlier studies that demonstrated estrogenic suppression of nonspecific cellular responsiveness, as evaluated by phytohemagglutinin-induced lymphocytic blastogenesis, and for the initally suggested concern over the efficacy of estrogenic therapy and its adverse effect on host cell-mediated immunologic responsiveness.
D000951:Antigens, Neoplasm / Q000276:immunology; D001943:Breast Neoplasms / Q000473:pathology; D002457:Cell Extracts / Q000276:immunology; D002478:Cells, Cultured; D003864:Depression, Chemical; D004054:Diethylstilbestrol / Q000494:pharmacology*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007957:Leukocyte Adherence Inhibition Test; D007962:Leukocytes / Q000276:immunology*; D008297:Male; D011471:Prostatic Neoplasms / Q000276:immunology* / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000473:pathology
D000951:Antigens, Neoplasm; D002457:Cell Extracts; D004054:Diethylstilbestrol