Antileukemia activity in the Osillatoriaceae: isolation of Debromoaplysiatoxin from Lyngbya.
Chloroform extracts of several seaweeds, of the family Oscillatoriaceae, from Enewetak Atoll, Marshall Islands, display activity against P-388 lymphocytic mouse leukemia. A P-388 active compound, debromoaplysiatoxin, has been isolated from Lyngbya gracilis and characterized. This compound also has dermonecrotic activity and may be the dermatitis-producing substance in L. majuscula, the causative agent of "swimmers' itch" outbreaks in Hawaiian waters.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000458:Cyanobacteria / Q000032:analysis; D003877:Dermatitis, Contact / Q000209:etiology; D007942:Leukemia, Experimental / Q000188:drug therapy*; D007945:Leukemia, Lymphoid / Q000188:drug therapy*; D051379:Mice; D010936:Plant Extracts / Q000627:therapeutic use*; D014118:Toxins, Biological / Q000302:isolation & purification / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D010936:Plant Extracts; D014118:Toxins, Biological