Formation of cross-linked molecules during vaccinia DNA replication.
The appearance of cross-linked DNA molecules during the replication of vaccinia virus DNA was investigated. Conversion of full size DNA molecules to cross-linked molecules occurs several hours after completion of DNA synthesis. Inhibition of RNA synthesis by actinomycin D did not prevent this transition; however, interruption of protein synthesis by streptovitacin A resulted in partial inhibition of the process.
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D003513:Cycloheximide / Q000031:analogs & derivatives / Q000494:pharmacology; D004261:DNA Replication; D004279:DNA, Viral / Q000096:biosynthesis*; D003609:Dactinomycin / Q000494:pharmacology; D007739:L Cells; D009690:Nucleic Acid Conformation; D014616:Vaccinia virus / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D004279:DNA, Viral; D003609:Dactinomycin; C005257:streptovitacin A; D003513:Cycloheximide