[Cerebral blood flow reactions to hypo- and hypercapnia during indomethacin inhibition of prostaglandin biosynthesis].
Acute experiments on cats demonstrated a suppression of the cerebral vessels reaction to hypercapnia under condithacin, while the reaction to hypocapnia persisted. It is assumed that the effects of hypo- and hypercapnia on the cerebral vessels were realized by different mechanisms, i. e. reduction of prostaglandin concentration decreased the cerebral vessels sensitivity to hypercapnia and increased their sensitivity to hypocapnia.
D000136:Acid-Base Equilibrium; D000818:Animals; D002245:Carbon Dioxide / Q000097:blood*; D002415:Cats; D002555:Cerebrospinal Fluid / Q000378:metabolism; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004285:Dogs; D006935:Hypercapnia / Q000503:physiopathology*; D006985:Hyperventilation / Q000503:physiopathology; D007213:Indomethacin / Q000494:pharmacology*; D010313:Partial Pressure; D011453:Prostaglandins / Q000096:biosynthesis*
D011453:Prostaglandins; D002245:Carbon Dioxide; D007213:Indomethacin
Reaktsii mozgovogo krovotoka na gipo- i giperkapniiu v usloviiakh ingibirovaniia biosinteza prostaglandinov indometatsinom.