Single versus fractionated doses of X-radiation and their effect on mammary carcinoma in the rat.
Selective destruction of neoplastic tissue by X-radiation, delivered as a single pulse or as a series of fractions, was investigated in transplanted DMBA-induced rat mammary tumors. Dosage was based on Strandqvist's fractionation curve, and compared with nominal standard doses. Tumor growth was most effectively inhibited when radiation was divided into three fractions. These results are consistent with predictions based on the NSD formula, rather than with the expected isoeffect of Strandqvist's curve. The higher doses of the three fractions were significantly more effective.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology / Q000532:radiotherapy*; D009368:Neoplasm Transplantation; D011879:Radiotherapy Dosage; D051381:Rats; D014184:Transplantation, Homologous; D014965:X-Rays
D015127:9,10-Dimethyl-1,2-benzanthracene