Hypnoticlike effects of cannabidiol in the rat.
The actions of cannabidiol (CBD), one of the cannabis constituents, were assessed on the sleep-wakefulness cycle of male Wistar rats. During acute experiments, single doses of 20 mg/kg CBD decreased slow-wave sleep (SWS) latency. After 40 mg/kg SWS time was significantly increased while wakefulness was decreased. REM sleep was not significantly modified. Following the once-daily injections of 40 mg/kg CBD for a period of 15 days, tolerance developed to all the above-mentioned effects.
D000818:Animals; D002185:Cannabidiol / Q000494:pharmacology*; D002186:Cannabinoids / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004361:Drug Tolerance; D006993:Hypnotics and Sedatives; D008297:Male; D051381:Rats; D012890:Sleep / Q000187:drug effects*; D014851:Wakefulness / Q000187:drug effects*
D002186:Cannabinoids; D006993:Hypnotics and Sedatives; D002185:Cannabidiol