[Chronologic study of free T3 and T4, of responses to TRH and of the suppression test during treatment of Basedow's disease].
32 patients with Graves' Disease were investigated before treatment, during ATD therapy and after recovery with a normal T3 suppression test. Before treatment, TRH response was negative with elevated values of plasma TT4, AFT4, TT3 and AFT3. The 3d, 6 - 9 and 12-18 months and after recovery, several patients remained unresponders to TRH despite normal AFT4 and AFT3 in serum. In an opposite way some patients were responders, 1 month after ATD withdrawal, at the 6-9 month, with elevated values of AFT4 or AFT3. The discrepancy between TRH response and T3 suppression test is pointed out after recovery. The unresponsiveness of TSH to TRH unexplained by serum AFT4 or AFT3 may be due to : 1) a decrease in pituitary TSH stores. 2) an unknown factor inhibiting TSH release during Graves' disease 3) an hypersensitivity of thyreotrop cells to T3.
D006111:Graves Disease / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D010903:Pituitary Gland, Anterior / Q000503:physiopathology; D013961:Thyroid Gland / Q000503:physiopathology*; D013972:Thyrotropin / Q000378:metabolism*; D013973:Thyrotropin-Releasing Hormone; D013974:Thyroxine / Q000097:blood*; D014284:Triiodothyronine / Q000097:blood*
D014284:Triiodothyronine; D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin; D013974:Thyroxine
Etude chronologique de la T3 et de la T4 libres, des réponses à la TRH et du test de freinage, au cours de la maladie de Basedow traitée.