Investigations of the antiviral activity of some nitroso-urea derivatives. Inhibitory action of the IOB-252 nitroso-urea derivative on vaccinia virus incell cultures.
The nitroso-urea derivative IOB-252 was administrered in monkey kidney cell cultures in a concentration of 40 mug/ml 24 hours before inoculation of vaccinia virus and maintained afterwards in a concentration of 25 mug/ml. The drug inhibited vaccinia virus multiplication, hemagglutinin synthesis and late cytopathic effect, but did not prevent early cytopathic lesions. IOB-252 inhibited the synthesis of interferon initiated by a viral inductor and blocked the antiviral effect of an exogeneous interferon. The mechanism of action of the drug is discussed.
D000818:Animals; D002460:Cell Line; D002478:Cells, Cultured; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D000882:Haplorhini; D006389:Hemagglutinins, Viral; D066298:In Vitro Techniques; D007372:Interferons / Q000096:biosynthesis; D007668:Kidney; D009607:Nitrosourea Compounds / Q000494:pharmacology*; D014616:Vaccinia virus / Q000187:drug effects*; D014776:Virus Cultivation; D014779:Virus Replication / Q000187:drug effects
D006389:Hemagglutinins, Viral; D009607:Nitrosourea Compounds; D007372:Interferons