Attenuation of stereotyped behaviour by sex steroids.
Effects of sex steroids, testosterone, progesterone, and estradiol on PEA-induced stereotyped behaviour (SB) has been studied in normal, castrated, and ovariectomised mice. Effects of sex steroids on amphetamine-induced sterotypy and hyperactivity are also described. In castrated and ovariectomised mice B-phenylethylamine (PEA) increased SB. Pretreatment with sex steroids attenuated PEA-induced stereotypy in normal, castrated, and ovarietomised mice. Sex steroid pretreatment significantly inhibited PEA- and amphetamine-induced SB, but failed to alter increased motor activity due to amphetamine or PEA. The possible effect of sec steroids on SB through changes in central neurotransmitters are discussed.
D000818:Animals; D001519:Behavior / Q000187:drug effects*; D002369:Castration; D005260:Female; D012739:Gonadal Steroid Hormones / Q000494:pharmacology*; D006801:Humans; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010293:Pargyline / Q000494:pharmacology; D010627:Phenethylamines / Q000494:pharmacology; D013239:Stereotyped Behavior / Q000187:drug effects*
D012739:Gonadal Steroid Hormones; D010627:Phenethylamines; D010293:Pargyline