Experimental pancreatic islet transplantation.
Transplantation of isolated islets of Langerhans has been suggested as a treatment of certain forms of diabetes mellitus. Injection of 200-400 syngeneic pancreatic islets isolated by collagenase digestion into the pancreas or submandibular gland of diabetic rats rendered most of the hosts nearly normoglycaemic. Blood glucose determinations were monitored for 2 months after islet transplantation. Although intrapancreatic and intrasubmandibular implantation reduced hyperglycaemia and polyuria in these animals, consistent normal values were rarely achieved.
D000818:Animals; D001786:Blood Glucose; D001835:Body Weight; D003920:Diabetes Mellitus / Q000628:therapy; D016381:Islets of Langerhans Transplantation; D010179:Pancreas / Q000601:surgery; D051381:Rats; D011917:Rats, Inbred Lew; D013363:Submandibular Gland / Q000601:surgery; D014185:Transplantation, Isogeneic
D001786:Blood Glucose