Screening hallucinogenic drugs II. Systematic study of two behavioral tests.
The effects of hallucinogenic and nonhallucinogenic drugs were studied on two behavioral tests: (1) discriminated Sidman avoidance, using modified Bovet-Gatti profiles, which have been proposed as specific in detecting hallucinogenic activity and (2) a drug discrimination experiment. By the first method, the "hallucinogenic profile" was obtained with both hallucinogenic and nonhallucinogenic drugs and, at least as used here, was not a suitable screening method. In the drug discrimination experiment, data from the present study along with other available evidence suggest the potential value of this method for drug screening procedures.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects*; D003216:Conditioning, Operant / Q000187:drug effects; D004193:Discrimination Learning / Q000187:drug effects; D004192:Discrimination, Psychological / Q000187:drug effects; D013759:Dronabinol / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005793:Generalization, Psychological / Q000187:drug effects; D006213:Hallucinogens / Q000494:pharmacology*; D008297:Male; D051381:Rats
D006213:Hallucinogens; D013759:Dronabinol