Insidious rifampin-associated renal failure with light-chain proteinuria.
A patient who was receiving rifampin treatment for tuberculosis developed heterogenous light-chain proteinuria and insidious renal failure after a period of fluid restriction. The renal damage was characterized pathologically by an interstitial nephritis with invasive tubular casts and an associated renal vein thrombosis. The possible role of the light-chain proteinuria in the pathogenesis of the renal failure is discussed.
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000473:pathology / Q000652:urine; D003681:Dehydration / Q000503:physiopathology; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000652:urine*; D008297:Male; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000139:chemically induced / Q000473:pathology; D011507:Proteinuria / Q000150:complications / Q000276:immunology*; D012293:Rifampin / Q000009:adverse effects*
D007147:Immunoglobulin Light Chains; D012293:Rifampin