A new animal model for testing the effectiveness of chemotherapeutic agents on renal adenocarcinoma.
A renal cell endocarcinoma that arose spontaneously in a Wistar-Lewis rat has been used to screen various chemotherapeutic agents for effectiveness against this tumor. Of the agents so far tested, cyclophosphamide (Cytoxan) and vinblastine have displayed very considerable anti-tumor activity. Adriamycin was marginal, and fluorouracil (5-FU) and Cis-dichlorodiammine Platinum (II) were ineffective.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002292:Carcinoma, Renal Cell / Q000188:drug therapy*; D004195:Disease Models, Animal; D004354:Drug Screening Assays, Antitumor; D007680:Kidney Neoplasms / Q000188:drug therapy*; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew; D011919:Rats, Inbred Strains
D000970:Antineoplastic Agents