title: Differences in localization of insulin receptors and adenylate cyclase in the human placenta.
abstract: The interactions of hormones with plasma membranes in the human placenta were characterized for specific fetal and maternal components. The microvillus brush border membrane, which is exposed to maternal blood in the intervillous space, was markedly enriched in specific insulin receptors but contained no hormone-sensitive adenylate cyclase. On the other hand, a basal plasma membrane fraction, which is presumably exposed more directly to fetal hormones, contained adenylate cyclase which was sensitive to prostaglandins, epinephrine, and fluoride but was not enriched in insulin receptors or other brush border markers. This study demonstrates separate fetal and maternal aspects of placental-hormone interactions. This separation and the relative impermeability of the placenta to hormones may allow for independent maternal and fetal components of the interaction of hormones with the placenta.
mesh_terms: D000262:Adenylyl Cyclases / Q000378:metabolism*; D002462:Cell Membrane / Q000201:enzymology; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D005459:Fluorides / Q000494:pharmacology; D006801:Humans; D008431:Maternal-Fetal Exchange; D008871:Microvilli / Q000201:enzymology / Q000378:metabolism; D010920:Placenta / Q000201:enzymology / Q000378:metabolism*; D011247:Pregnancy; D011458:Prostaglandins E / Q000494:pharmacology; D011460:Prostaglandins F / Q000494:pharmacology; D011972:Receptor, Insulin / Q000378:metabolism*
chemical_list: D011458:Prostaglandins E; D011460:Prostaglandins F; D011972:Receptor, Insulin; D000262:Adenylyl Cyclases; D005459:Fluorides; D004837:Epinephrine