In vivo behaviour of neuraminidase-treated rabbit erythrocytes and reticulocytes.
51Cr rabbit erythrocytes were treated with different amount of neuraminidase and reinjected into the animal. The survival curves after the removal of more than 50% membrane sialic acid show a characteristic behaviour: after a rapid decrease, blood radioactivity increases again reaching a maximum level 50-80 h after reinjection, then tends to decrease with a slope similar to that of control curves. Liver radioactivity determined before the rise of blood radioactivity is evidently higher than the value determined after radioactivity elevation. Similar results were obtained with phenylhydrazine-induced young erythrocytes.
D000818:Animals; D001804:Blood Transfusion, Autologous; D004905:Erythrocyte Aging / Q000187:drug effects; D004910:Erythrocyte Membrane / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects*; D008099:Liver; D009439:Neuraminidase / Q000494:pharmacology*; D011817:Rabbits; D012156:Reticulocytes / Q000187:drug effects*; D012794:Sialic Acids / Q000097:blood; D013154:Spleen; D013997:Time Factors
D012794:Sialic Acids; D009439:Neuraminidase