Thromboxane B-2 in the plasma and amniotic fluid of late pregnant and periparturient sheep.
The concentration of thromboxane (TX) B-2 was similar in plasma from all sources but was significantly greater (P less than 0.01) in amniotic fluid. Fetal hypophysectomy was without effect on maternal or fetal levels of TXB-2 (P greater than 0.1). Neither normal parturition at term nor prematurely induced delivery was associated with any significant trend in TXB-2 levels. During late pregnancy (105--145 days of gestation) the concentrations of TXB-2 and 13, 14-dihydro-15-keto-prostaglandin F (PGFM) in maternal and fetal plasma were significantly correlated (P less than 0.001). There was, however, no correlation between TXB-2 and PGFM levels in samples taken during the 36 h before delivery. These data suggest that thromboxanes play little part in the mechanism of parturition in sheep.
D000653:Amniotic Fluid / Q000032:analysis*; D000818:Animals; D005260:Female; D005312:Fetal Blood / Q000032:analysis; D007016:Hypophysectomy; D007743:Labor, Obstetric; D010902:Pituitary Gland / Q000196:embryology; D011247:Pregnancy; D011270:Pregnancy, Animal; D011460:Prostaglandins F / Q000097:blood; D011863:Radioimmunoassay; D012756:Sheep / Q000378:metabolism*; D013929:Thromboxane B2 / Q000032:analysis* / Q000097:blood; D013931:Thromboxanes / Q000032:analysis*
D011460:Prostaglandins F; D013931:Thromboxanes; D013929:Thromboxane B2