title: [The sella turcica and pituitary function in congenital hypothyroidism due to thyroid ectopia or hypogenesis (author's transl)].
abstract: Nine patients suffering from hypothyroidism due to thyroid ectopia or hypogenesis, with a large sella turcica, were examined at adolescence or during adult life. TSH, prolactin and growth hormone function were studied. Basal plasma TSH, evaluated in 5 cases, was raised and responded explosively to stimulation with TRH. The administration of L-dopa was not associated with any notable changes in TSH. In one case, the chronic administration of l-T3 resulted in a fall followed by normalisation in plasma TSH levels. Basal plasma prolactin, explored in 6 patients, was high in 4 females and normal in 2 males. TRH stimulation resulted in a marked increased in prolactin in the female cases and a moderate increase in the male cases. L-dopa caused a fall only in high prolactin values. Stimulation of GH by argininehydrochloride, insulin hypoglycaemia and L-dopa gave variable responses. In one case, substitutive thyroid hormone therapy restored the GH response to L-dopa and arginine hydrochloride to normal. Paradoxically, GH increase following stimulation with TRH.
mesh_terms: D000293:Adolescent; D000328:Adult; D001120:Arginine; D002940:Circadian Rhythm; D003409:Congenital Hypothyroidism; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D007037:Hypothyroidism / Q000503:physiopathology; D007328:Insulin; D007980:Levodopa; D008297:Male; D008875:Middle Aged; D010901:Pituitary Function Tests; D010902:Pituitary Gland / Q000503:physiopathology*; D011388:Prolactin / Q000097:blood; D011859:Radiography; D012658:Sella Turcica / Q000000981:diagnostic imaging; D013961:Thyroid Gland / Q000002:abnormalities*; D013972:Thyrotropin / Q000097:blood; D013973:Thyrotropin-Releasing Hormone
chemical_list: D007328:Insulin; D007980:Levodopa; D013973:Thyrotropin-Releasing Hormone; D011388:Prolactin; D013972:Thyrotropin; D013006:Growth Hormone; D001120:Arginine
vernacular_title: Selle turcique et fonction hypophysaire au cours des hypothyroïdies congénitales par ectopie ou hypogénésie thyroïdienne.