[Effect of prostaglandin E2 (PgE2) on the biosynthesis and metabolism of noradrenaline (NA) in the isolated and perfused rabbit heart].
In isolated perfused rabbit heart, Pg E2 at concentrations ranging from 1.10(-8) to 1.10(-4) M has shown no significant action either on the biosynthesis or on the metabolism of NA. But it inhibited NA uptake, nevertheless this action was weak.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D006321:Heart / Q000187:drug effects*; D009206:Myocardium / Q000378:metabolism; D009638:Norepinephrine / Q000096:biosynthesis / Q000378:metabolism*; D010477:Perfusion; D011458:Prostaglandins E / Q000494:pharmacology*; D011817:Rabbits; D013564:Sympathetic Nervous System / Q000502:physiology
D011458:Prostaglandins E; D009638:Norepinephrine
Etude de l'action de la prostaglandine E2 (PgE2) sur la biosynthèse et la destinée de la noradrénaline (NA) au niveau du coeur isolé et perfusé de lapin.