Impaired pancreatic polypeptide release in chronic pancreatitis with steatorrhoea.
Pancreatic polypeptide (PP) is a newly discovered hormonal peptide localised in a distinct endocrine cell type in the pancreas. PP circulates in plasma and in normal subjects levels rise substantially on the ingestion of food (mean rise 138 pmol/l). In 10 patients with chronic pancreatitis with exocrine deficiency the PP response to a test breakfast was greatly reduced (mean rise 20 pmol/l, P less than 0.001). PP response to the meal was normal in 10 patients with active coeliac disease and 12 patients with acute tropical sprue with steatorrhoea.
D000328:Adult; D000368:Aged; D002446:Celiac Disease / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D002908:Chronic Disease; D006801:Humans; D008875:Middle Aged; D010191:Pancreatic Polypeptide / Q000097:blood / Q000378:metabolism*; D010195:Pancreatitis / Q000097:blood / Q000150:complications / Q000503:physiopathology*
D010191:Pancreatic Polypeptide