title: Cryoprecipitate: its use and effects in canine coagulum pyelolithotomy.
abstract: A fibrin clot forming an extractable cast or "coagulum" of the pyelocalyceal system was developed and characterized using a blood product not previously described--single donor type specific cryoprecipitate. The physical properties of the cryoprecipitate coagulum were investigated and compared with other described formulations. Simulated coagulum pyelolithotomy was performed in vivo in 11 canine kidneys with no adverse effect upon creatinine clearance or anatomic integrity. The advantages of the cryoprecipitate are detailed and a new, simplified operative technique is described.
mesh_terms: D000818:Animals; D001831:Body Temperature; D003404:Creatinine / Q000097:blood; D004285:Dogs; D005169:Factor VIII / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005340:Fibrinogen / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007669:Kidney Calculi / Q000097:blood / Q000601:surgery*; D007682:Kidney Pelvis / Q000601:surgery; D008722:Methods; D013696:Temperature; D013718:Tensile Strength
chemical_list: D005169:Factor VIII; D005340:Fibrinogen; D003404:Creatinine