Thyrotropin-releasing hormone: stimulation of colonic activity following intracerebroventricular administration.
Intraventricularly administered thyrotropin-releasing hormone in rabbits elicited an increase in intraluminal pressure changes, a response commonly associated with muscular activity of the colon. The response appears to be central in origin with peripheral expression relying primarily on cholinergic receptors.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002714:Chlorisondamine / Q000494:pharmacology; D003106:Colon / Q000294:innervation / Q000502:physiology*; D005769:Gastrointestinal Motility; D006874:Hydrostatic Pressure; D007275:Injections, Intravenous; D007276:Injections, Intraventricular; D008297:Male; D010275:Parasympathetic Nervous System / Q000502:physiology; D011817:Rabbits; D011976:Receptors, Muscarinic / Q000187:drug effects; D013973:Thyrotropin-Releasing Hormone / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*
D011976:Receptors, Muscarinic; D013973:Thyrotropin-Releasing Hormone; D001285:Atropine; D002714:Chlorisondamine