Respiratory distress syndrome and the value of amniotic fluid phospholipids in predicting such complications before birth.
The amniotic fluid study of 80 samples from 40 patients, obtained by amniocentesis between 28 and 40 weeks of pregnancy, was carried out. It was noted that L/S (Lecithin/Sphingomyelin) ratio was significantly different at 36-38 weeks of pregnancy when compared with values in pregnancies of less than 36 weeks gestation (P less than 0001). No cases of RDS occurred when the L/S ratio was mature 4 or more. A brief review of recent developments in etiology of RDS are also presented.
D000649:Amniocentesis; D000653:Amniotic Fluid / Q000032:analysis* / Q000378:metabolism; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D010713:Phosphatidylcholines / Q000032:analysis* / Q000096:biosynthesis / Q000378:metabolism; D011247:Pregnancy; D011296:Prenatal Diagnosis; D012127:Respiratory Distress Syndrome, Newborn / Q000175:diagnosis*; D013109:Sphingomyelins / Q000032:analysis* / Q000378:metabolism
D010713:Phosphatidylcholines; D013109:Sphingomyelins