[Glucose tolerance and muscular efficiency (author's transl)].
Glucose tolerance and insulin secretion were studied in 15 male patients suffering from muscular dystrophies. Creatinine excretion was used as a measure of functioning muscle mass. The decrease in glucose tolerance correlated significantly with the injury of muscular efficiency. Despite impaired glucose tolerance, very high levels of circulating insulin were reached, as in obese diabetics. The observations do not simply reflect the decrease in distribution volume of glucose. They can be explained by an altered proportion of muscle mass to adipose and connective tissue. Decreased glucose tolerance may signalize the myopathic reaction following an endocrine disorder or a malignant disease.
D000293:Adolescent; D000328:Adult; D002648:Child; D003404:Creatinine / Q000652:urine; D005947:Glucose / Q000378:metabolism*; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000503:physiopathology*; D009136:Muscular Dystrophies / Q000378:metabolism / Q000503:physiopathology*
D007328:Insulin; D003404:Creatinine; D005947:Glucose
Glucosetoleranz und Funktionstüchtigkeit der Muskulatur.