Studies on polypeptides. XXIX. Synthesis of the N-terminal tetradecapeptide sequence of ribonuclease A, incorporating beta-(3-pyridyl)-L-alanine at position 12.
A description is given of the synthesis by fragment condensation of 12-(3-Pyd) Ala S-peptide (1--14), the 1--14 peptide sequence of ribonuclease A in which the histidine-12 residue is replaced by beta-(3-pyridyl)-L-alanine. The peptide binds strongly and stoichiometrically to S-protein; the resulting complex is enzymatically inactive.
D000409:Alanine; D000595:Amino Acid Sequence; D010446:Peptide Fragments; D010455:Peptides / Q000138:chemical synthesis*; D012260:Ribonucleases / Q000138:chemical synthesis*
D010446:Peptide Fragments; D010455:Peptides; D012260:Ribonucleases; D000409:Alanine