Chemical sterilization of male langurs: synergistic action of alpha-chlorohydrin (U-5897) with methallibure (ICI, 33828) on the testes and epididymides of Presbytis entellus entellus Dufresne.
1. Synergistic action of alpha-chlorohydrin with methallibure (ICI, 33828) on the testicular function of Presbytis entellus entellus Dufresne has been studied. 2. Chronic administration of alpha-chlorohydrin alone (140 mg/day for 40 days) caused testicular lesion resulting in a massive atrophy of the spermatogenic elements. Epididymal epithelium was regressed and the lumen was devoid of spermatozoa. 3. alpha-Chlorohydrin inhibited the synthesis of RNA and sialic acid in the testes and epididymides. Total cholesterol per gram of testis and alkaline phosphatase activity were increased after alpha-chlorohydrin administration. 4. These effects could be achieved with a lower dose of alpha-chlorohydrin (1/4) when administered in combination with a gonadotrophin inhibitor, i. e. ICI, 33828 (Methallibure). Methallibure alone (200 mg/kg: total dose) has no damaging effects on the testes and epididymides. But it altered testicular cholesterol and enzyme activity. 5. In conclusion, an effective inhibition of spermatogenesis could be achieved by synergistic action of the two different drugs i. e. alpha-chlorohydrin and ICI, 33828 (Methallibure).
D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002728:Chlorohydrins / Q000494:pharmacology*; D002784:Cholesterol / Q000378:metabolism; D004357:Drug Synergism; D004822:Epididymis / Q000187:drug effects / Q000502:physiology*; D000882:Haplorhini; D006651:Histocytochemistry; D007985:Leydig Cells / Q000187:drug effects / Q000502:physiology; D008297:Male; D008693:Methallibure / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D012671:Seminiferous Tubules / Q000187:drug effects / Q000502:physiology; D012794:Sialic Acids / Q000378:metabolism; D013245:Sterilization, Reproductive; D013737:Testis / Q000187:drug effects / Q000502:physiology*; D013890:Thiourea / Q000031:analogs & derivatives*; D000517:alpha-Chlorohydrin / Q000494:pharmacology*
D002728:Chlorohydrins; D012794:Sialic Acids; D000517:alpha-Chlorohydrin; D002784:Cholesterol; D000469:Alkaline Phosphatase; D013890:Thiourea; D008693:Methallibure