Effect of penicillin on streptomycin production by Streptomyces griseus.
The correlation between the biosynthesis of the cell wall and the formation of streptomycin (SM) in Streptomyces griseus, influenced by a specific inhibitor of cell wall synthesis, was investigated. Penicillin, in subinhibitory concentrations (1 to 5 mug/ml), was added to cultures of S. griseus in different stages of its life cycle. The inhibitor decreased SM production, when young cultures were treated; however, there was an increase in SM formation when penicillin was added to older cultures. The explanation for these findings is discussed in detail.
D002473:Cell Wall / Q000187:drug effects / Q000378:metabolism; D010400:Penicillin G / Q000494:pharmacology*; D013305:Streptomyces griseus / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D013307:Streptomycin / Q000096:biosynthesis*; D013997:Time Factors
D010400:Penicillin G; D013307:Streptomycin