title: [Cardiac output and central-hemodynamic parameter under bencyclan (author's transl)].
abstract: In 17 patients with peripheral arterial occlusive disease the influence of intra-veinously applicated Bencyclane (Fludilat) on cardiac output and central-hemodynamic parameter has been investigated. While 100 mg (n = 8) of Bencyclane almost do not influence cardiac output, 200 mg (n = 9) cause a significant decrease of minute-volume of the heart by-17.22% and of heartfrequency by-8.85%. With either dose there is also a significant increase of aortic pressure, pulmonary arterial pressure and pulmonary vessel resistance to be seen. These results correlate with the animal-experimental proof of a negative inotropy under Bencyclane, and they have to be considered in therapeutical use.
mesh_terms: D001157:Arterial Occlusive Diseases / Q000188:drug therapy; D001537:Bencyclane / Q000009:adverse effects / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects*; D003508:Cycloheptanes / Q000494:pharmacology*; D003864:Depression, Chemical; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D009200:Myocardial Contraction / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D003508:Cycloheptanes; D001537:Bencyclane
vernacular_title: Herzminutenvolumen und zentralhämodynamische Parameter unter Bencyclan (Fludilat).