[Inhibition of lymphocyte blastogenesis by diazepam, meprobamate, and other psychotropic drugs].
Imipramine, diazepam, chlordiazepoxide, and meprobamate inhibit incorporation of 3H-thymidine in human lymphocytes in culture. For the first three drugs, 50% inhibition occurs at a concentration of 5 X 10(-5) M, and for meprobamate at a concentration of 10(-3 M. Ethanol has no action up to 10(-1) M.
D002707:Chlordiazepoxide / Q000494:pharmacology*; D003975:Diazepam / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D013759:Dronabinol / Q000494:pharmacology; D000431:Ethanol / Q000494:pharmacology; D006801:Humans; D007099:Imipramine / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects*; D008620:Meprobamate / Q000494:pharmacology*
D000431:Ethanol; D002707:Chlordiazepoxide; D013759:Dronabinol; D008620:Meprobamate; D007099:Imipramine; D003975:Diazepam
Inhibition de la blastogenèse lymphocytaire par le diazépam, le méprobamate et d'autres drogues psychotropes