Biochemical and behavioural effects of hypoxic hypoxia in rats: study of the protection afforded by ergot alkaloids.
The conditioned avoidance response and the cerebral levels of dopamine and noradrenaline have been studied in control rats and in rats submitted to a hypobaric hypoxia. A protection against the effects of hypoxia was induced by both dihydroergocornine (20 microgram/kg) and dihydroergocryptine (100 microgram/kg), and the noradrenaline level did not decrease. This stabilization of cerebral noradrenaline level seems to be the main protection factor observed.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001921:Brain / Q000378:metabolism; D002395:Catecholamines / Q000378:metabolism*; D004088:Dihydroergotoxine / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004877:Ergoloid Mesylates / Q000494:pharmacology*; D005260:Female; D002534:Hypoxia, Brain / Q000378:metabolism* / Q000517:prevention & control; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats
D002395:Catecholamines; D004088:Dihydroergotoxine; D004877:Ergoloid Mesylates; D004298:Dopamine; D009638:Norepinephrine