Liquid storage of bone marrow.
A program of nonfrozen autologous bone marrow rescue was used to treat patients with refractory nonhematological neoplasms. In vitro storage of bone marrow cells and CFU-C suggests that storage at 4 degrees or 10 degrees for periods up to five days can be undertaken with only minor loss of CFU-C. However, since the loss occurred in a gradual fashion, shorter duration of storage would probably be better. Hematological recovery after high dose chemotherapy occurred faster in patients given more CFU-C and those with shortest duration of storage prior to reinfusion.
D001853:Bone Marrow / Q000502:physiology*; D016026:Bone Marrow Transplantation; D003080:Cold Temperature; D003114:Colony-Forming Units Assay; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D011309:Preservation, Biological / Q000379:methods*; D013997:Time Factors