An unusual kappa immunoglobulin antigen present on the membrane of T and B lymphocytes.
Several K immunoglobulin antisera out of a large number studied showed the unique property of reacting with a membrane structure present on all T and B lymphocytes examined. This antigen was detected on lymphocytes by indirect fluorescence, direct fluorescence, and by cytotoxic analysis. Absorption of the antiserum by all K myeloma proteins, K Bence-Jones proteins, and kappa light chains removed the activity; L proteins had no effect. The possibility that the cross-reacting membrane antigen is part of the HL-A system was discussed.
D000918:Antibody Specificity; D001402:B-Lymphocytes / Q000276:immunology*; D002462:Cell Membrane / Q000276:immunology; D003601:Cytotoxicity Tests, Immunologic; D006680:HLA Antigens; D006801:Humans; D007106:Immune Sera; D007147:Immunoglobulin Light Chains / Q000032:analysis*; D007145:Immunoglobulin kappa-Chains / Q000032:analysis*; D009194:Myeloma Proteins / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D006680:HLA Antigens; D007106:Immune Sera; D007147:Immunoglobulin Light Chains; D007145:Immunoglobulin kappa-Chains; D009194:Myeloma Proteins