Successful treatment of pseudomonas aeruginosa--ventriculitis with intraventricular gentamicin in a child with hydrocephalus.
A hydrocephalic child, who was operated with a ventriculo-peritoneal shunt at the age of 1 month, developed ventriculitis due to Pseudomonas aeruginosa at 8 months. After removal of the shunt and successively increasing intramuscular and intraventricular doses of gentamicin the patient was cured and a new shunt could be inserted. As high 24-hour gentamicin level in the cerebrospinal fluid as 76 microgram/ml was reached without any apparent toxic signs.
D002557:Cerebrospinal Fluid Shunts; D004660:Encephalitis / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage / Q000134:cerebrospinal fluid / Q000627:therapeutic use*; D006801:Humans; D006849:Hydrocephalus / Q000601:surgery*; D007223:Infant; D007273:Injections, Intramuscular; D007276:Injections, Intraventricular; D011183:Postoperative Complications / Q000188:drug therapy; D011552:Pseudomonas Infections / Q000188:drug therapy*; D011550:Pseudomonas aeruginosa
D005839:Gentamicins