title: [Pharmacokinetics and results of clinical administration of CS-1170. I. Pharmacokinetics of CS-1170 (author's transl)].
abstract: (1) When 20.8 approximately 34.7 mg/kg body weight of CS-1170 were instilled intravenously for 30 minutes to one hour, peak levels were obtained on completion of the intravenous drip in the range 85.7 approximately 1,117.3 microgram/ml. (2) The half life was 22 approximately 49 minutes which is very rapid. (3) The kidney clearance was 6.8 approximately 104.8 ml/min. (4) The total clearance was 5.9 approximately 111.5 ml/min, showing correlation with the kidney clearance. (5) The apparent distributional capacity was 0.3 approximately 4.3 liters, showing a strong correlation with body weight.
mesh_terms: D001424:Bacterial Infections / Q000188:drug therapy; D002511:Cephalosporins / Q000378:metabolism*; D002513:Cephamycins / Q000008:administration & dosage / Q000378:metabolism* / Q000652:urine; D002648:Child; D002675:Child, Preschool; D005260:Female; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D008297:Male; D013997:Time Factors
chemical_list: D002511:Cephalosporins; D002513:Cephamycins