Bowen's disease and squamous cell carcinoma. Occurrence in a patient with psoriasis after topical, systemic, and PUVA therapy.
Multiple lesions of Bowen's disease and squamous cell carcinoma on the penis and pubic areas developed in a 32-year-old patient with psoriasis who was undergoing treatment with psoralen and long-wave ultraviolet radiation (PUVA). A cumulative dose of more than 3,700 joules/sq cm of UVA had been administered over a three-year period. This case may be an early warning of possible carcinogenicity of PUVA therapy, alone or as part of sequential therapy with other agents.
D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000209:etiology*; D003033:Coal Tar / Q000009:adverse effects; D003043:Cocarcinogenesis; D005938:Glucocorticoids / Q000009:adverse effects; D006801:Humans; D006918:Hydroxyurea / Q000009:adverse effects; D008297:Male; D008727:Methotrexate / Q000009:adverse effects; D008730:Methoxsalen / Q000009:adverse effects; D010412:Penile Neoplasms / Q000209:etiology*; D010778:Photochemotherapy / Q000009:adverse effects; D011565:Psoriasis / Q000188:drug therapy*; D012878:Skin Neoplasms / Q000209:etiology*; D014801:Vitamin A / Q000009:adverse effects
D005938:Glucocorticoids; D014801:Vitamin A; D003033:Coal Tar; D008730:Methoxsalen; D006918:Hydroxyurea; D008727:Methotrexate