[Activity of the principal alkaloids of Polyalthia oliveri Engler (Annonaceac) on the central nervous system and the cardiovascular system].
Polyalthia oliveri leaf alkaloid, oliveroline, shows in Mice antiparkinsonian properties which decrease or disappear with the alkaloïds extracted from the bark of the trunk, oliveridine and oliverine. The latter alkaloid has an antihypertensive effect which is not found in oliveridine, only hypotensive by a relaxant close to papaverine action on vascular smooth muscles.
D000470:Alkaloids / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology; D000978:Antiparkinson Agents / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects*; D002490:Central Nervous System / Q000187:drug effects*; D051379:Mice; D010946:Plants, Medicinal / Q000032:analysis*; D011817:Rabbits; D051381:Rats; D014665:Vasodilator Agents / Q000494:pharmacology
D000470:Alkaloids; D000959:Antihypertensive Agents; D000978:Antiparkinson Agents; D014665:Vasodilator Agents
Activité des principaux alcaloïdes de Polyalthia oliveri Engler (Annonacées) sur le système nerveux central et le systéme cardio-vasculaire