Adrenergic inputs to the amygdala and the control of gonadotrophin release.
Drugs able to mimic or to antagonize the action of catecholamines have been implanted bilaterally into the basomedial region of the amygdala of adult castrated female rats. The animals were killed at different intervals after the implantation of the different drugs, and serum levels of LH and FSH were measured by radioimmunoassay. The results have shown that the intra-amygdalar implantation of the alpha-adrenergic blocker phenoxybenzamine induces a significant increase of the release both of LH and FSH. The implantation of the beta-adrenergic blocker propranolol brings about a rise of LH only. The dopamine receptor blocker pimozide stimulates the release of LH and exerts a biphasic effect (stimulation followed by inhibition) of FSH secretion. The alpha-receptor stimulant clonidine and the dopaminergic drug 2-Br-alpha-ergocryptine were without significant effects. From these observations it is suggested that the adrenergic signals reaching the basomedial area of the amygdala (possibly from the brain stem) may be involved in the modulation of gonadotrophin secretion.
D000320:Adrenergic Fibers / Q000187:drug effects / Q000502:physiology*; D000679:Amygdala / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology; D002369:Castration; D003000:Clonidine / Q000494:pharmacology; D004343:Drug Implants; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood / Q000378:metabolism*; D007986:Luteinizing Hormone / Q000097:blood / Q000378:metabolism*; D010643:Phenoxybenzamine / Q000008:administration & dosage / Q000494:pharmacology; D010868:Pimozide / Q000008:administration & dosage / Q000494:pharmacology; D011433:Propranolol / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects
D004343:Drug Implants; D011954:Receptors, Dopamine; D010643:Phenoxybenzamine; D010868:Pimozide; D001971:Bromocriptine; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D011433:Propranolol; D003000:Clonidine