Effect of otolith end organ ablation on pendular rotation nystagmus in squirrel monkeys.
Damped pendular rotation nystagmus was studied in squirrel monkeys before and after otolith end organ ablation (two-stage operations). After each operation, the nystagmic slow phase eye speed toward the operated side was reduced (to about 73% of that before the operation) and that to the non-operated side did not show any marked change. A few subjects showed spontaneous nystagmus with amphetamine administration but only in dark (could not be found in light) immediately after the operation, and it disappeared rapidly. Therefore, this post-ablative reduction of the slow phase eye speed is considered to result from the loss of inputs from the otolith end organs.
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D007758:Ear, Inner / Q000187:drug effects / Q000294:innervation* / Q000601:surgery; D004584:Electronystagmography; D005133:Eye Movements; D005260:Female; D000882:Haplorhini; D008297:Male; D008566:Membranes / Q000601:surgery; D012444:Saccule and Utricle / Q000601:surgery; D012453:Saimiri; D011984:Sensory Receptor Cells / Q000502:physiology* / Q000601:surgery
D000661:Amphetamine