Degradation of hypothalamic hormones.
The enzymatic fragmentation of TRH (pyroGlu-His-Pro-NH2) by serum, hypothalamic and hypophyseal tissue was investigated. As primary cleavage product only His-Pro-NH2 was detected when TRH was incubated with serum while with the tissue preparations the formation of His-Pro-NH2, deamido-TRH and prolineamide could be detected as enzymatically formed primary fragments.
D000818:Animals; D006868:Hydrolysis; D007031:Hypothalamus / Q000201:enzymology; D010902:Pituitary Gland / Q000201:enzymology; D051381:Rats; D013973:Thyrotropin-Releasing Hormone / Q000378:metabolism*
D013973:Thyrotropin-Releasing Hormone