Colchicine-estrogen interactions.
Colchicine does not block estrogen-induced recognition of uterine blood vessel surface by eosinophils, but interfers with their migration through endothelial lining and therefore blocks estrogen-induced uterine eosinophilia and edema.
D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D003078:Colchicine / Q000494:pharmacology*; D004487:Edema / Q000209:etiology; D004804:Eosinophils / Q000187:drug effects*; D004958:Estradiol / Q000494:pharmacology*; D004965:Estrogen Antagonists; D005260:Female; D009215:Myometrium / Q000166:cytology; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D014599:Uterus / Q000033:anatomy & histology / Q000187:drug effects*
D004965:Estrogen Antagonists; D004958:Estradiol; D003078:Colchicine