title: Failure of anticholinergic drugs to antagonize the increase in dopamine seen after gammahydroxybutyric acid and axotomy.
abstract: The increase in dopamine (DA) seen either 30 or 90 min after injection of gammahydroxybutyric acid or 90 min after axotomy of the nigrostriatal DA-fibers was not affected by i.p. injections of either atropine sulfate or atropine methyl nitrate or benztropine. These increases in DA are most probably due to feedback-mechanisms which do not involve cholinergic neurons.
mesh_terms: D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D001369:Axons / Q000378:metabolism; D001590:Benztropine / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism*; D003342:Corpus Striatum / Q000378:metabolism; D004298:Dopamine / Q000096:biosynthesis* / Q000378:metabolism; D006885:Hydroxybutyrates / Q000494:pharmacology*; D008297:Male; D009434:Neural Pathways / Q000378:metabolism; D051381:Rats; D013378:Substantia Nigra / Q000378:metabolism; D014326:Tropanes / Q000494:pharmacology*
chemical_list: D006885:Hydroxybutyrates; D014326:Tropanes; D001590:Benztropine; D001285:Atropine; D004298:Dopamine