Case-control study: soft-tissue sarcomas and exposure to phenoxyacetic acids or chlorophenols.
In 1977 a number of patients with soft-tissue sarcomas and previous exposure to phenoxyacetic acids were described. Following from these observations a matched case-control study was made. Exposure to chlorophenols was also included in this study. The results showed that exposure to phenoxyacetic acids or chlorophenols gave an approximately 6-fold increase in the risk for this type of tumour. It was not possible to determine, however, whether the carcinogenic effect was exerted by these compounds or by impurities such as chlorinated dibenzodioxins and dibenzofurans that in almost all cases were part of the commercial preparations.
D015085:2,4,5-Trichlorophenoxyacetic Acid / Q000009:adverse effects; D015084:2,4-Dichlorophenoxyacetic Acid / Q000009:adverse effects; D008456:2-Methyl-4-chlorophenoxyacetic Acid / Q000009:adverse effects; D000328:Adult; D000368:Aged; D002733:Chlorophenols / Q000009:adverse effects*; D003634:DDT / Q000009:adverse effects; D004147:Dioxins / Q000009:adverse effects; D004781:Environmental Exposure; D005663:Furans / Q000009:adverse effects; D006016:Glycolates / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012509:Sarcoma / Q000139:chemically induced* / Q000453:epidemiology; D012983:Soft Tissue Neoplasms / Q000139:chemically induced* / Q000453:epidemiology; D013548:Sweden
D002733:Chlorophenols; D004147:Dioxins; D005663:Furans; D006016:Glycolates; D015084:2,4-Dichlorophenoxyacetic Acid; D015085:2,4,5-Trichlorophenoxyacetic Acid; D003634:DDT; D008456:2-Methyl-4-chlorophenoxyacetic Acid