A rapid, sensitive technique to assay penicillamine levels in blood and urine.
We have used a rapid, sensitive technique to assay penicillamine and its disulphide metabolites in body fluids. Penicillamine in serum is rapidly oxidized and the serum levels of the reduced material found in a pilot study of 10 patients ranged between 0.07 to 0.28 mg%. This technique may prove useful in allowing closer monitoring of therapy with this agent.
D001172:Arthritis, Rheumatoid / Q000097:blood / Q000188:drug therapy / Q000378:metabolism* / Q000652:urine; D004912:Erythrocytes / Q000201:enzymology*; D006801:Humans; D007668:Kidney / Q000378:metabolism; D008722:Methods; D010396:Penicillamine / Q000378:metabolism* / Q000627:therapeutic use; D010865:Pilot Projects; D013997:Time Factors
D010396:Penicillamine