[Result of the administration of high doses of bumetanide to patients with chronic renal failure who are on a program of hemodialysis (author's transl)].
High doses of furosemide were given to patients with chronic renal failure who were on a program of dialysis with the aim of achieving less frequent dialysis or a more liberal diet for these patients. The result of the oral administration of 12 mg of bumetanide per day in 12 patients with renal insufficiency submitted to periodic hemodialysis were evaluated. The residual renal function of these patients varied between 1.5 and 6 ml/min of creatinine clearance. A significant variation could not be established in the predialysis values of urea, creatinine or potassium, nor of the interdialysis weight increase, nor of the urinary excretion of Na and K. On the contrary, the predialysis natremia levels varied from 133 to 138 mEq/l (p less than 0.01) under the effect of the medication and this coincided with a significant increase of the diuresis. As secondary effect the authors frequently recorded myalgia of variable intensity without significant changes in the serum enzymes of muscular origin.
D000284:Administration, Oral; D000328:Adult; D002034:Bumetanide / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D004231:Diuresis / Q000187:drug effects; D004232:Diuretics / Q000008:administration & dosage*; D004341:Drug Evaluation; D005260:Female; D005665:Furosemide / Q000008:administration & dosage; D006801:Humans; D007676:Kidney Failure, Chronic / Q000188:drug therapy / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000139:chemically induced; D006435:Renal Dialysis
D004232:Diuretics; D002034:Bumetanide; D005665:Furosemide
Resultado de la administración de dósis elevadas de bumetanide en pacientes con insuficiencia renal crónica en programa de hemodiálisis.