Transmitter-specific retrograde labeling in the striato-nigral and raphe-nigral pathways.
Injecting radioactive transmitters into the rat substantia nigra led to retrograde neuronal labeling either in the dorsal raphe nucleus, after 3H-labeled serotonin injection, or in the caudoputamen, after 3H-labeled gamma-aminobutyric acid injection. This differential labeling in projections whose transmitter has been established provides the basis for a histochemical tracing method indicating both connectivity and transmitter specificity of neural pathways.
D000818:Animals; D001933:Brain Stem / Q000502:physiology*; D002421:Caudate Nucleus / Q000166:cytology; D003342:Corpus Striatum / Q000166:cytology / Q000502:physiology*; D005260:Female; D009434:Neural Pathways; D011699:Putamen / Q000166:cytology; D011903:Raphe Nuclei / Q000166:cytology / Q000502:physiology*; D051381:Rats; D012701:Serotonin; D013378:Substantia Nigra / Q000166:cytology / Q000502:physiology*; D005680:gamma-Aminobutyric Acid
D012701:Serotonin; D005680:gamma-Aminobutyric Acid