The role of plasma amine oxidase, platelet monoamine oxidase, and red cell catechol-O-methyl transferase in severe behavioral reactions to disulfiram.
The authors assayed platelet monoamine oxidase (MAO), plasma amine oxidase (AO), and red cell catechol-O-methyl transferase (COMT) in 32 male alcoholics before they began disulfiram treatment. Seven subjects developed psychotic reactions to disulfiram; these 7 had significantly lower pretreatment MAO and AO levels and significantly higher COMT than the patients who had no adverse reactions to disulfiram, which suggests that severe behavioral reactions to disulfiram are associated with differences in enzyme activities.
D000293:Adolescent; D000328:Adult; D000437:Alcoholism / Q000534:rehabilitation; D001792:Blood Platelets / Q000201:enzymology*; D002394:Catechol O-Methyltransferase / Q000097:blood*; D004221:Disulfiram / Q000009:adverse effects* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000201:enzymology*; D006801:Humans; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000097:blood*; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000097:blood*; D011605:Psychoses, Substance-Induced / Q000201:enzymology* / Q000209:etiology; D012189:Retrospective Studies
D008995:Monoamine Oxidase; D000587:Oxidoreductases Acting on CH-NH Group Donors; D002394:Catechol O-Methyltransferase; D004221:Disulfiram