Effect of certain additives on the dissolution rate of chloramphenicol.
A study was conducted on the effect of certain additives on the dissolution rate of chloramphenicol. The effect of adsorbents, natural and synthetic surface active agents, diluents and lubricants was studied. Many of these additives increased the dissolution rate of chloramphenicol from capsules.
D000438:Alcohols; D002214:Capsules; D002241:Carbohydrates; D002626:Chemistry, Pharmaceutical; D002701:Chloramphenicol / Q000032:analysis*; D003080:Cold Temperature; D005079:Excipients; D012995:Solubility; D013228:Stearates; D013501:Surface-Active Agents; D013997:Time Factors
D000438:Alcohols; D002214:Capsules; D002241:Carbohydrates; D005079:Excipients; D013228:Stearates; D013501:Surface-Active Agents; D002701:Chloramphenicol