Levels of exfoliatin antitoxin in pooled human serum globulin.
The potential value of human serum globulin for treatment of patients with the staphylococcal scalded-skin syndrome was determined by measuring the exfoliatin antitoxin content of globulin pools. Of 16 lots tested, only four had detectable antitoxin activity, and in these the levels were minimal. These findings suggest that pooled serum globulin is not a practical source of exfoliatin antitoxin.
D000818:Animals; D000992:Antitoxins / Q000494:pharmacology* / Q000627:therapeutic use; D001427:Bacterial Toxins / Q000037:antagonists & inhibitors*; D001681:Biological Assay; D005083:Exfoliatins / Q000037:antagonists & inhibitors* / Q000276:immunology; D006801:Humans; D051379:Mice; D011817:Rabbits; D012712:Serum Globulins / Q000276:immunology / Q000494:pharmacology* / Q000627:therapeutic use; D012874:Skin Diseases, Infectious / Q000188:drug therapy; D013203:Staphylococcal Infections / Q000188:drug therapy
D000992:Antitoxins; D001427:Bacterial Toxins; D005083:Exfoliatins; D012712:Serum Globulins