title: [Sniffing addiction: chronic solvent abuse with neurotoxic effects in children and juveniles (author's transl)].
abstract: 25 cases of clinically severe toxic polyneuropathy were observed among young people in Berlin who were addicted to sniffing methylethylketone-containing solvents. The peripheral motor defects took 2 1/2 to 3 years to regress. In severe cases there were additional spastic signs. This form of neurotoxic effect can be reproduced in animals. It is due to a disorder of axonal transport which destroys peripheral and central axons.
mesh_terms: D000293:Adolescent; D000336:Aerosols; D001554:Benzene; D001604:Berlin; D005260:Female; D005860:Germany, West; D006801:Humans; D006838:Hydrocarbons; D008297:Male; D009133:Muscular Atrophy / Q000139:chemically induced; D009422:Nervous System Diseases / Q000139:chemically induced; D012903:Smell; D012924:Social Conditions; D012997:Solvents; D019966:Substance-Related Disorders / Q000150:complications / Q000453:epidemiology
chemical_list: D000336:Aerosols; D006838:Hydrocarbons; D012997:Solvents; D001554:Benzene
vernacular_title: Schnüffelsucht. Chronischer Lösungsmittelmissbrauch bei Kindern und Jugendlichen mit neurotoxischen Folgen.