Immunologic mechanisms in nephritogenesis.
At least two different immunopathologic pathways that together account for most clinical nephritis have been delineated. Most common is the situation in which antigen-antibody complexes form in the circulation and lodge in renal basement membranes. The second involves antibodies to specific kidney structures. Both may initiate inflammatory injuries that adversely alter glomerular and tubular function.
D000906:Antibodies; D000936:Antigen-Antibody Complex; D001485:Basement Membrane / Q000276:immunology; D005921:Glomerulonephritis / Q000276:immunology; D006801:Humans; D009393:Nephritis / Q000276:immunology*
D000906:Antibodies; D000936:Antigen-Antibody Complex