[Haemoperfusion on coated activited charcoal. Experience in French anti-poison centres based upon 60 cases (author's transl)].
Sixty three sessions of haemoperfusion on coated activated charcoal were carried out in 60 cases of poisoning. The indications concerned 2 clinical situations: - massive poisoning with coma (by hypnotics or chlorine-containing solvents) with high extracellular concentrations of the toxic agent, with the aim of reducing the duration of the coma; - intoxications with a high mortality rate, such as those due to paraquat, colchicine, digitoxine, tricyclic antidepressants, and heavy metals, even when plasma levels were low in relation to the dose ingested. Such discordance may be related not only to predominantly intracellular fixation, but also to low intestinal absorption. The effectiveness of haemoperfusion was estimated in terms of the amount of toxic substance extracted, measured either indirectly by repeated calculation of the arteriovenous difference multiplied by the flow rate through the column, or directly by elution of the column. This method for the removal of toxic substances would not appear to be life-saving, is too costly for the extraction obtained and is not free from specific complications. Thrombocytopaenia remains an epiphenomenon, but the frequency of infection is significantly higher than with haemodialysis. An effective and safe method for the vascular extraction of poisons, particularly one favourising removal of toxic substances from intracellular localisation, remains to be found.
D000929:Antidepressive Agents, Tricyclic / Q000506:poisoning; D002606:Charcoal; D002698:Chloralose / Q000506:poisoning; D003078:Colchicine / Q000506:poisoning; D003128:Coma / Q000139:chemically induced / Q000628:therapy; D004074:Digitoxin / Q000506:poisoning; D005602:France; D006464:Hemoperfusion / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000506:poisoning; D010269:Paraquat / Q000506:poisoning; D011039:Poison Control Centers; D011041:Poisoning / Q000401:mortality / Q000628:therapy*
D000929:Antidepressive Agents, Tricyclic; D006993:Hypnotics and Sedatives; D002606:Charcoal; D002698:Chloralose; D004074:Digitoxin; D010269:Paraquat; D003078:Colchicine
L'hémoperfusion sur charbon activé enrobé expérience des centres anti-poisons français: 60 intoxications.