Myotonia, potassium and taurine. A preliminary report.
The effect of taurine administration upon potassium-induced muscular hyperexcitability was studied in patients affected with dystrophic myotonia and in normal volunteers. Intra-arterial infusions of increasing concentrations of potassium chloride were given and venous potassium levels simultaneously monitored. Taurine prevented or remarkably reduced the electric signs of muscular hyperexcitability. Potassium chloride and taurine effects upon muscular excitability are discussed in terms of changes of membrane conductance, particularly for potassium ions.
D000200:Action Potentials; D002463:Cell Membrane Permeability; D006801:Humans; D009132:Muscles / Q000503:physiopathology*; D009223:Myotonic Dystrophy / Q000188:drug therapy* / Q000503:physiopathology; D011188:Potassium; D013654:Taurine / Q000627:therapeutic use*
D013654:Taurine; D011188:Potassium