title: Synthesis and pharmacological screening of certain N-substituted amides structurally related to some local anesthetics.
abstract: Diphenylacetyl chloride and pivaloyl chloride have been condensed with a wide variety of amines. Some of the resulting amides showed local anesthetic properties higher than those of procaine hydrochloride.
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000494:pharmacology; D000779:Anesthetics, Local / Q000138:chemical synthesis*; D000818:Animals; D003315:Cornea / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D005260:Female; D006168:Guinea Pigs; D008297:Male; D012867:Skin / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000577:Amides; D000779:Anesthetics, Local