Dosage schedule for intravenous aminophylline in apnoea of prematurity, based on pharmacokinetic studies.
15 preterm infants were treated for recurrent apnoea with theophylline. 5 were given oral choline theophyllinate, but this was erratically absorbed. 14 were given IV aminophylline on 23 occasions. Apparent volume of distribution of theophylline in 12 infants was 0.71 +/- 0.18 1/kg (mean +/- SD). Plasma clearance rate measured in 11 infants at steady state was 18.6 +/- 4.8 ml/kg per hour. Calculations show that a loading dose of 6.2 mg/kg aminophylline intravenously and maintenance of 4.4 mg/kg per day would produce serum levels of between 6 and 12 mg/l in all but one of the infants studied, with no infant having toxic levels.
D000628:Aminophylline / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use; D001049:Apnea / Q000097:blood / Q000188:drug therapy*; D004334:Drug Administration Schedule; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000097:blood / Q000188:drug therapy*; D007263:Infusions, Parenteral; D008657:Metabolic Clearance Rate; D013806:Theophylline / Q000627:therapeutic use
D000628:Aminophylline; D013806:Theophylline