title: [Pentoxifylline medication within the scope of leg-ulcer therapy. Results of a field study using Trental 400].
abstract: 513 patients with chronic ulcers of the leg were treated with Trental 400 orally in addition to local therapy. Regarding the reduction of the symptoms: ulcer extension, coldness of the leg, paraesthesia, resting pain and improvement of walking distance, 215 patients were classified as considerably improved, 195 distinctly improved, 53 slightly improved and 44 unchanged. Four cases worsened, two cases could not be classified. The possibility of combining oral therapy with local treatment and surgical measures (skin-flaps) is shown in three case reports. Gastro-intestinal tolerance of Trental 400 was good, interactions with concomitantly administered drugs were not reported.
mesh_terms: D000284:Administration, Oral; D000368:Aged; D004359:Drug Therapy, Combination; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D007871:Leg Ulcer / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010431:Pentoxifylline / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D013805:Theobromine / Q000031:analogs & derivatives*; D013997:Time Factors
chemical_list: D013805:Theobromine; D010431:Pentoxifylline
vernacular_title: Pentoxifyllin-Medikation im Rahmen der Ulcus cruris-Behandlung. Ergebnisse einer Feldstudie mit Trental 400.