Brominated benzene induction of hepatic porphyria.
Unlike the highly porphyrinogenic fungicide hexachlorobenzene, hexabromobenzene was a poor inducer of porphyria. Similarly, 1,2-dibromobenzene and 1,2,4-tribromobenzene, while causing small increases in hepatic porphyrins, did not increase ALA synthetase or the urinary excretion of porphobilinogen (PBG), aminolevulinic acid (ALA) or porphyrins.
D000622:Aminolevulinic Acid / Q000378:metabolism; D000818:Animals; D001969:Bromobenzenes; D005260:Female; D008099:Liver / Q000378:metabolism; D011164:Porphyrias / Q000139:chemically induced*; D011166:Porphyrins / Q000378:metabolism / Q000652:urine; D051381:Rats; D013329:Structure-Activity Relationship
D001969:Bromobenzenes; D011166:Porphyrins; D000622:Aminolevulinic Acid