A novel interaction involving a polypeptide chain (P33) in covalent linkage with IgM on the surface of a Burkitt lymphoma cell line (Daudi).
The surface IgM of Daudi Burkitt lymphoma cells has been shown to consist of mu chains and kappa chains covalently linked, by disulfide bonding, to a novel polypeptide chain of approximate molecular weight 33,000. This novel polypeptide chain (P33) is similar in several properties to the heavy chain of the Ia antigen: glycoprotein nature; apparent molecular weight; isoelectric behavior and cysteine content. The linkage of P33 to surface immunoglobulin has not been observed with any other human lymphoma or lymphoblastoid cell lines.
D001665:Binding Sites; D002051:Burkitt Lymphoma / Q000276:immunology*; D002460:Cell Line; D055598:Chemical Phenomena; D011232:Chemical Precipitation; D002621:Chemistry; D003545:Cysteine; D004220:Disulfides / Q000494:pharmacology; D006801:Humans; D007075:Immunoglobulin M; D007457:Iodine Radioisotopes; D007930:Leucine / Q000378:metabolism; D010455:Peptides; D011947:Receptors, Antigen, B-Cell
D004220:Disulfides; D007075:Immunoglobulin M; D007457:Iodine Radioisotopes; D010455:Peptides; D011947:Receptors, Antigen, B-Cell; D007930:Leucine; D003545:Cysteine