Does 15-hydroxy prostaglandin dehydrogenase contribute to prostaglandin inactivation in brain?
15-Methyl prostaglandin E2, a compound which is not a substrate for 15-hydroxy prostaglandin dehydrogenase, is a more potent pyretic agent than prostaglandin E2 when injected into the third ventricle of conscious cats. This finding raises the possibility that 15-hydroxy prostaglandin dehydrogenase contributes to prostaglandin inactivation in brain, notwithstanding its low activity.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001921:Brain / Q000201:enzymology / Q000378:metabolism*; D002415:Cats; D004305:Dose-Response Relationship, Drug; D005260:Female; D006911:Hydroxyprostaglandin Dehydrogenases / Q000378:metabolism / Q000502:physiology*; D007276:Injections, Intraventricular; D008297:Male; D011458:Prostaglandins E / Q000008:administration & dosage / Q000378:metabolism* / Q000494:pharmacology; D011459:Prostaglandins E, Synthetic / Q000008:administration & dosage / Q000378:metabolism* / Q000494:pharmacology
D011458:Prostaglandins E; D011459:Prostaglandins E, Synthetic; D006911:Hydroxyprostaglandin Dehydrogenases