title: Incidence of polyspermy in mouse eggs fertilized in vivo and in vitro after administration of progesterone and oestradiol.
abstract: Female mice, induced to superovulate, were injected subcutaneously with progesterone or oestradiol near the time when hCG was given. The incidence of polyspermy in first-cleavage embryos following mating or in-vitro fertilization was then determined. There were no detectable differences in the incidence or degree of polyspermy between treated and control in either the in-vitro or in-vivo groups, although the mean incidence of polyspermy was higher in vitro than in vivo. Furthermore, there was no detectable acceleration of egg transport after administration of either hormone.
mesh_terms: D000818:Animals; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D005306:Fertilization; D005307:Fertilization in Vitro / Q000187:drug effects*; D051379:Mice; D011374:Progesterone / Q000494:pharmacology*; D013480:Superovulation
chemical_list: D006063:Chorionic Gonadotropin; D011374:Progesterone; D004958:Estradiol