title: Activation of initial wound healing responses in rat corneas in organ culture by mesodermal growth factor.
abstract: In organ culture, mesodermal growth factor (MGF) from mouse submaxillary glands stimulates fibroblast formation, mitosis, and migration of cells into the dead-cell zone adjacent to the wound edge of rat corneal buttons. A classic dose-response relationship between the width of the stromal fibroblast zone and the dose of MGF suggests that fibroblast zone width may be used as a measure for screening agents which influence the initial stages of corneal wound healing.
mesh_terms: D000818:Animals; D003315:Cornea / Q000502:physiology*; D005260:Female; D005347:Fibroblasts / Q000187:drug effects; D006133:Growth Substances / Q000494:pharmacology*; D008297:Male; D008648:Mesoderm / Q000502:physiology; D008938:Mitosis / Q000187:drug effects; D009924:Organ Culture Techniques; D051381:Rats; D013363:Submandibular Gland / Q000502:physiology; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D006133:Growth Substances