[Stability of the immunogenic properties of plague vaccine strain EV, Research Institute of Epidemiology and Hygiene line, during long-term storage].
The experiments in guinea pigs showed that the immunogenic properties of plague vaccine strain EV, line NIIEG, freeze-dried in 1947 and stored under vacuum without animalization, remained unchanged for 30 years. The subcultures prepared from this train showed, after three passages in guinea pigs, good immunogenic properties which preserved for 6--10 years (the term of observation). After 30-years storage the stock culture of strain EV, line NIIEG, can be used for the preparation of NIIS live plague vaccine.
D000818:Animals; D001428:Bacterial Vaccines / Q000276:immunology*; D003470:Culture Media; D004306:Dose-Response Relationship, Immunologic; D004355:Drug Stability; D004356:Drug Storage; D006168:Guinea Pigs; D007114:Immunization; D011309:Preservation, Biological; D013997:Time Factors; D014586:USSR
D001428:Bacterial Vaccines; D003470:Culture Media
Stabil'nost' immunogennykh svoĭstv chumnogo vaktsinnogo shtamma EV linii NIIEG v usloviiakh dlitel'nogo khraneniia.