The enhancing effect of multiple sclerosis brain homogenates on the active E-rosette forming lymphocytes in neurological disorders.
Peripheral blood lymphocytes from 23 out of 27 (85%) patients with multiple sclerosis responded to MS brain homogenates by increased formation of active E-rosettes. Lymphocytes from only six out of 78 (8%) patients with other neurological diseases responded to MS brain homogenates. The possible value of the test in the diagnosis of MS is discussed.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000941:Antigens; D001921:Brain / Q000276:immunology*; D002493:Central Nervous System Diseases / Q000175:diagnosis / Q000276:immunology*; D003937:Diagnosis, Differential; D006801:Humans; D008214:Lymphocytes / Q000276:immunology*; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000276:immunology*; D012397:Rosette Formation / Q000295:instrumentation
D000941:Antigens