Combined therapy of leukemia La with Damvar and cytostatics.
The new cytostatic drug Damvar, delta-(2-amino-6-hydroxy-3,4-dihydro-4-oxo-5-pyrimidinyl)valeric acid, is not effective in La leukemia system. Damvar given in combination with 5-fluorouracil enhanced the anti-La effect of 5-Fu. There was also enhancement of the antileukemic effect of suboptimal and optimal doses of cyclophosphamide with the addition of Damvar.
D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage*; D003520:Cyclophosphamide / Q000008:administration & dosage*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005472:Fluorouracil / Q000008:administration & dosage*; D007942:Leukemia, Experimental / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011743:Pyrimidines / Q000008:administration & dosage*; D011744:Pyrimidinones
D000964:Antimetabolites, Antineoplastic; D011743:Pyrimidines; D011744:Pyrimidinones; C019161:damvar; D003520:Cyclophosphamide; D005472:Fluorouracil