The effect of cerulenin and exogenous fatty acids on triacylglycerol accumulation in an inositol-deficient yeast, Saccharomyces carlsbergensis.
Cerulenin inhibits fatty acid synthesis in yeast; supplementation with exogenous fatty acids is required to maintain cell growth. In the presence of cerulenin and exogenous fatty acids inositol-deficient cells accumulate triacylglycerols to almost the same extent as normally grown deficient cells, indicating that increased fatty acid synthesis is not primarily responsible for triacylglycerol accumulation.
D000935:Antifungal Agents / Q000494:pharmacology*; D002569:Cerulenin / Q000494:pharmacology*; D005227:Fatty Acids / Q000378:metabolism / Q000494:pharmacology*; D007294:Inositol / Q000172:deficiency*; D012440:Saccharomyces / Q000187:drug effects / Q000378:metabolism*; D014280:Triglycerides / Q000378:metabolism*
D000935:Antifungal Agents; D005227:Fatty Acids; D014280:Triglycerides; D002569:Cerulenin; D007294:Inositol