title: Drug-induced blood dyscrasias. A ten-year material from the Swedish Adverse Drug Reaction Committee.
abstract: Drug-induced dyscrasias (agranulocytosis, aplastic anemia, hemolytic anemia and thrombocytopenia) in Sweden during a 10-year period (1966-75) have been analyzed. The overall occurrence is remarkably constant, although marked changes have occurred with regard to offending drugs. Drug-induced thrombocytopenia and agranulocytosis are about twice as common as hemolytic anemia, which in turn is twice as common as aplastic anemia. There is a marked increase with age in the incidence of all drug-induced cytopenias. Women predominate and make up close to 70% of the material. With regard to responsible drugs, the most remarkable finding is the high frequency with which sulfonamides appear as responsible for all types of drug-induced cytopenia.
mesh_terms: D000367:Age Factors; D000380:Agranulocytosis / Q000139:chemically induced / Q000453:epidemiology; D000741:Anemia, Aplastic / Q000139:chemically induced / Q000453:epidemiology; D000743:Anemia, Hemolytic / Q000139:chemically induced / Q000453:epidemiology; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006402:Hematologic Diseases / Q000139:chemically induced*; D006801:Humans; D008297:Male; D012737:Sex Factors; D013449:Sulfonamides / Q000009:adverse effects / Q000627:therapeutic use; D013548:Sweden; D013921:Thrombocytopenia / Q000139:chemically induced / Q000453:epidemiology
chemical_list: D013449:Sulfonamides