Electrophysiological actions of chlorimipramine on guinea-pig ventricular fibres.
Chlorimipramine (CMI, 1 x 10(-5)M to 7 X 10(-5)M) decreased the amplitude, overshoot and rate of rise of ventricular action potentials and abolished the Ca-mediated action potentials elicited in guinea-pig papillary muscles. These results indicates that CMI inhibits the rise in sodium and calcium conductances during the cardiac action potential.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002118:Calcium / Q000378:metabolism; D002997:Clomipramine / Q000494:pharmacology*; D003984:Dibenzazepines / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004553:Electric Conductivity; D006168:Guinea Pigs; D006352:Heart Ventricles / Q000187:drug effects*; D007545:Isoproterenol / Q000494:pharmacology; D016276:Ventricular Function
D003984:Dibenzazepines; D007545:Isoproterenol; D002997:Clomipramine; D002118:Calcium