Inhibition of aflatoxin B1-induced cytotoxicity and binding to DNA in cultured rat liver cells by naturally occurring flavones.
For naturally occurring flavones, quercetin, fisetin, nobiletin, and tangeritin, protect cultured rat liver epithelial-like cells against aflatoxin B1-induced cytotoxicity and inhibit the binding of [3H] aflatoxin B1 to cellular DNA. The methoxy-substituted flavones, nobiletin and tangeritin, show greater protection against cytotoxicity than do the hydroxy-substituted compounds, quercetin and fisetin.
D000348:Aflatoxins / Q000037:antagonists & inhibitors* / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004247:DNA / Q000378:metabolism*; D004847:Epithelial Cells; D005419:Flavonoids / Q000494:pharmacology*; D008099:Liver / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051381:Rats; D013997:Time Factors
D000348:Aflatoxins; D005419:Flavonoids; D004247:DNA