[Enflurane anaesthesia and plasma cortisol (author's transl)].
The influence of enflurane on adrenocortical function was investigated by determining the concentration of plasma cortisol by a radioimmunoassay during general anaesthesia and abdominal operations. Thirty minutes after the start of anaesthesia with enflurane 0.8--2.0%, N2O:O2 (2:1) and pancuronium, the plasma cortisol decreased slightly in the preoperative period; it increased markedly and continuously during the intra- and postoperative period. There was no correlation between plasma concentrations of enflurane, determined by gas chromatography, and cortisol.
D000302:Adrenal Cortex / Q000187:drug effects; D000328:Adult; D000768:Anesthesia, General; D004737:Enflurane / Q000097:blood / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D008738:Methyl Ethers / Q000494:pharmacology*; D008875:Middle Aged
D008738:Methyl Ethers; D004737:Enflurane; D006854:Hydrocortisone
Enflurane-Narkose und Plasma-Cortisol.