Active E rosette-forming cells in the peripheral blood of patients with chronic active hepatitis.
E rosette-forming cells (E-RFC) and active E-RFC were studied in the peripheral blood in patients with chronic active hepatitis (CAH), chronic persistent hepatitis (CPH), and in control subjects. A significant reduction in active E-RFC (a subpopulation of T lymphocytes considered actively involved in cell-mediated immune reactions) was found in patients with untreated CAH, both HBSAg positive or negative. In contrast, patients with immunosuppressive-treated CAH showed an increased relative number of active E-RFC. A significant increase in active E-RFC was demonstrable in other immunosuppressive-treated chronic inflammatory disorders. In CPH active E-RFC were not different from normal controls. The number of E-RFC showed a relative and absolute decrease in both CPH and untreated CAH. These studies demonstrate an increase in active E-RFC in immunosuppressive-treated CAH and suggest that prednisone and azathioprine may have a differential effect on T lymphocyte subpopulations.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002908:Chronic Disease; D006505:Hepatitis / Q000276:immunology*; D006801:Humans; D007165:Immunosuppression Therapy; D008103:Liver Cirrhosis / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D008875:Middle Aged; D012397:Rosette Formation