title: An unusual case of carbamazepine poisoning with a near-fatal relapse after two days.
abstract: A severe case of carbamazepine is described in which the drug and its major metabolite were monitored by means of HPLC. After 2 days of treatment a dramatic rise in plasma concentration of carbamazepine and its metabolite was observed, accompanied by a relapse into deep coma, then followed by a rapid elimination of the drugs and complete recovery within 4 days. The possible mechanisms underlying these phenomena and potential therapeutic measures are discussed.
mesh_terms: D000328:Adult; D002220:Carbamazepine / Q000097:blood / Q000494:pharmacology / Q000506:poisoning*; D005260:Female; D005751:Gastric Lavage; D005769:Gastrointestinal Motility / Q000187:drug effects; D006801:Humans; D007408:Intestinal Absorption; D013997:Time Factors
chemical_list: D002220:Carbamazepine