Pharmacokinetics/pharmacodynamics of furosemide in man: a review.
The pharmacokinetics of furosemide and the attempt to correlate biological fluid measurements with diuretic response have been the subject of a large number of studies since the original reports of Hajdú, Rupp, and coworkers in the mid-1960s. This article attempts to critically review these studies under seven different sections: furosemide pharmacokinetics in normal volunteers, furosemide pharmacokinetics in patients with decreased renal function, furosemide pharmacokinetics in patients with congestive heart failure, furosemide metabolism and assay methods, furosemide bioavailability, dose-response relationships, and the role of inhibitors and mediators on furosemide effects. The literature is reviewed through August 1978.
D001682:Biological Availability; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005665:Furosemide / Q000378:metabolism* / Q000494:pharmacology; D006333:Heart Failure / Q000378:metabolism; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology; D007674:Kidney Diseases / Q000378:metabolism; D007700:Kinetics; D011339:Probenecid / Q000494:pharmacology
D005665:Furosemide; D011339:Probenecid; D007213:Indomethacin