Prevention of protein extravasation in the brain by an anion transport inhibitor in acute experimental hypertension in rats.
Acute experimental hypertension induces protein leakage in the brain. The protein is thought to be, at least to a great extent, transported through the endothelial cells by pinocytosis. An anion transport inhibitor, 4 acetamido-4-isothiocyano-stilbene-2,2'-disulfonic acid, markedly reduced adrenaline or bicuculline-induced leakage of 125IHSA and Evans blue-albumin in all areas of the rat brain. The preventive effect of dexamethasone was less pronounced and no effect was seen of haloperidol.
D000208:Acute Disease; D000818:Animals; D000838:Anions; D001640:Bicuculline / Q000494:pharmacology; D001798:Blood Proteins / Q000378:metabolism*; D001812:Blood-Brain Barrier / Q000187:drug effects; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis; D003907:Dexamethasone / Q000494:pharmacology; D004727:Endothelium / Q000378:metabolism; D004837:Epinephrine / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology; D006973:Hypertension / Q000378:metabolism*; D008297:Male; D010873:Pinocytosis / Q000187:drug effects; D051381:Rats; D012711:Serum Albumin, Radio-Iodinated / Q000134:cerebrospinal fluid; D013267:Stilbenes / Q000494:pharmacology*
D000838:Anions; D001798:Blood Proteins; D002556:Cerebrospinal Fluid Proteins; D012711:Serum Albumin, Radio-Iodinated; D013267:Stilbenes; D003907:Dexamethasone; D006220:Haloperidol; D001640:Bicuculline; D004837:Epinephrine