Simultaneous determination of isosorbide dinitrate and its mononitrates in human plasma by capillary column GLC.
A previously described electron-capture GLC method for determination of isosorbide dinitrate in human plasma was adapted for the simultaneous determination of isosorbide dinitrate, isosorbide 2-mononitrate, and isosorbide 5-mononitrate using a capillary column. Quantitation was done with two internal standards. The lower limits of detection were approximately 0.5 ng/ml of plasma for isosorbide dinitrate, 2 ng/ml for isosorbide 2-mononitrate, and 20 ng/ml for isosorbide 5-mononitrate.
D001711:Biotransformation; D002849:Chromatography, Gas; D006801:Humans; D007547:Isosorbide / Q000097:blood; D007548:Isosorbide Dinitrate / Q000097:blood*; D008722:Methods; D009566:Nitrates / Q000097:blood
D009566:Nitrates; D007548:Isosorbide Dinitrate; D007547:Isosorbide