Prevention of muscle necrosis in an experimental neurovascular island muscle flap by a vasodilator drug--isoxsuprine.
We report an experiment that demonstrates one means to prevent necrosis in an experimental island muscle flap. The results imply that necrosis of skeletal muscle in a clinical flap could be prevented by treatment with isoxsuprine.
D000818:Animals; D005452:Fluoresceins; D007274:Injections, Intraperitoneal; D007556:Isoxsuprine / Q000494:pharmacology / Q000627:therapeutic use*; D009132:Muscles / Q000098:blood supply / Q000473:pathology / Q000601:surgery*; D009336:Necrosis / Q000517:prevention & control*; D011817:Rabbits; D012039:Regional Blood Flow / Q000187:drug effects
D005452:Fluoresceins; D007556:Isoxsuprine