[Pharmacological activity and toxicity of neurotropic agents in experimental hypodynamia].
Comparison of ED50, the indices of pharmacological range, LD50, risk coefficients, the size of the area of toxic activity, maximal tolerated and absolute lethal doses showed in acute experiments on intact and "hypodynamic" mice that under conditions of a short-term tension-producing hypodynamia in the animals, the pharmacological activity of the test neurotropic agents exhibiting a central action changes, whereas their toxicity remains unchanged.
D000818:Animals; D002491:Central Nervous System Agents / Q000494:pharmacology* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D012149:Restraint, Physical; D013997:Time Factors
D002491:Central Nervous System Agents
Farmakologicheskaia aktivnost' i toksichnost' nekotorykh neĭrotropnykh sredstv v usloviiakh éksperimental'noĭ gipodinamii.