H-Y binding in the gonad: inhibition by a supernatant of the fetal ovary.
H-Y antigen, the product of mammalian testis-determining genes, is released in the free state by testicular cells. Molecules of free H-Y antigen are bound in vitro by dispersed cells of the adult ovary. The binding reaction is inhibited by specific H-Y antibody. It is also inhibited by a diffusible factor of the newly differentiated fetal ovary. These observations favor the view that testicular organogenesis depend upon dissemination and binding of H-Y molecules by cells of the undifferentiated gonad (XY or XX, both having H-Y receptors), and raise the question of whether ovarian organogenesis may be promoted by a "female" molecule corresponding to H-Y of the male.
D000818:Animals; D000937:Antigen-Antibody Reactions; D001665:Binding Sites; D005260:Female; D006182:H-Y Antigen; D008297:Male; D051379:Mice; D010053:Ovary / Q000196:embryology / Q000378:metabolism*; D012733:Sex Differentiation
D006182:H-Y Antigen