Lack of ozone effects on oxygen hemoglobin affinity.
Ozone exposure has been shown to cause erythrocyte damage and thus may be affecting oxygen delivery by the red cell. Oxyhemoglobin affinity, heme-oxygen binding site interaction (Hill coefficient), and red cell 2,3-diphosphoglycerate concentrations were measured in a total of twenty-two New Zealand white rabbits exposed to ozone. Ozone exposures of 1 and 3 ppm for 4 hr in rabbits had no significant (P greater than .05) effect, immediate or delayed, on the parameters measured.
D000818:Animals; D001665:Binding Sites / Q000187:drug effects; D004163:Diphosphoglyceric Acids / Q000097:blood; D004912:Erythrocytes / Q000032:analysis; D006418:Heme / Q000378:metabolism; D008297:Male; D010100:Oxygen / Q000097:blood; D010108:Oxyhemoglobins / Q000378:metabolism*; D010126:Ozone / Q000009:adverse effects*; D010313:Partial Pressure; D011817:Rabbits
D004163:Diphosphoglyceric Acids; D010108:Oxyhemoglobins; D006418:Heme; D010126:Ozone; D010100:Oxygen