title: [Clinical studies on PC-904 in biliary tract diseases (author's transl)].
abstract: The clinical effects of PC-904, a new semisynthetic penicillin, were studied in patients with biliary tract diseases, and the results were as follows: 1) PC-904 showed an average peak serum level of 40.7 +/- 11.6 microgram/ml 2 hours after an intravenous drip infusion of 1 g of the agent. The biliary level showed a peak value of 126.5 +/- 85.4 microgram/ml 2 hours to 3 hours after the infusion. 2) Isolated organisms from bile before the treatment were E. coli, Klebsiella, Proteus, Pseudomonas, Enterococcus and Bacteroides. MIC of PC-904 on 18 strains of isolated organisms was almost 6.25 microgram/ml or less. All isolated organisms except one strain of Klebsiella oxytoca disappeared after the treatment. 3) Six patients with cholelithiasis were medicated with PC-904 to prevent post-operative infections. The clinical effects were good in 4, poor in 1 and unknown in 1 case. 4) As to side effects no adverse reactions and allergic reactions were noted. Also no significant abnormalities of laboratory findings were observed.
mesh_terms: D000667:Ampicillin / Q000031:analogs & derivatives* / Q000032:analysis / Q000494:pharmacology / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects; D001646:Bile / Q000032:analysis / Q000382:microbiology; D001659:Biliary Tract / Q000032:analysis; D001660:Biliary Tract Diseases / Q000188:drug therapy*; D006801:Humans; D009287:Naphthyridines / Q000032:analysis / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D009287:Naphthyridines; C012122:apalcillin; D000667:Ampicillin