title: Kinetics of fluphenazine after fluphenazine dihydrochloride, enanthate and decanoate administration to man.
abstract: 1 Fluphenazine (1,2-ethanol 14C) was administered to seven human subjects as the dihydrochloride and as the enanthate and decanoate esters. 2 The subjects had previously been treated with fluphenazine injections for at least 6 months. 3 Fluphenazine was separated from its radioactive metabolites by selective solvent extraction. Plasma concentrations were measured for up to 21 days after dosing. 4 The preparations showed differences in peak concentrations, times of the peaks and half-times of the elimination phase. The longest half-times occurred with the decanoate and the shortest with the dihydrochloride. 5 It is postulated that the differences in kinetics relate principally to the release of the compound from the site of injection. 6 There was no evidence for presence of the esters in plasma, urine or faeces.
mesh_terms: D000328:Adult; D002712:Chlorides / Q000378:metabolism; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D003651:Decanoates / Q000378:metabolism; D005476:Fluphenazine / Q000031:analogs & derivatives / Q000097:blood / Q000378:metabolism*; D006207:Half-Life; D006537:Heptanoates / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D002712:Chlorides; D003651:Decanoates; D006537:Heptanoates; D005476:Fluphenazine