HLA in populations: an approach for genetical susceptibility to cancer.
The geographical correlations between the incidence of various cancers and the HLA and ABO antigen frequencies are studied. There is, for example, a positive correlation between breast and colorectal carcinoma and AI, B8 and B12 antigens, and a negative one between prostate carcinoma and B12. The role of the HLA system itself or other genes involved in these associations is discussed. This study gives some evidence of a possible genetic background of susceptibility or resistance to cancer.
D000017:ABO Blood-Group System / Q000235:genetics; D000349:Africa; D044466:Asian People; D001315:Australia; D044383:Black People; D005060:Europe; D005260:Female; D005787:Gene Frequency; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000235:genetics / Q000276:immunology*; D009656:North America; D013020:South America; D044465:White People
D000017:ABO Blood-Group System; D006680:HLA Antigens