title: Premalignant lesions of the stomach.
abstract: The histopathogenesis of the three major types of gastric carcinoma--intestinal, diffuse and indeterminate--is reviewed, considering normal and abnormal cell kinetics of the gastric mucosa. Intestinalization is a precursor of intestinal-type carcinoma and is related to environmental factors. Diffuse gastric carcinoma originates from dysplasia of the neck of the gland and is of nonenvironmental, probably genetic, origin.
mesh_terms: D002277:Carcinoma / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D005753:Gastric Mucosa / Q000166:cytology / Q000473:pathology; D006801:Humans; D007414:Intestinal Neoplasms / Q000473:pathology; D008679:Metaplasia / Q000473:pathology; D011230:Precancerous Conditions / Q000473:pathology*; D013274:Stomach Neoplasms / Q000473:pathology*