title: [Effect of diphtheria toxin on the release and extractability of histones from the liver cell nuclei of guinea pigs].
abstract: The release and extraction of histones from the nuclei of guinea pig liver under the influence of diphteria  toxin was investigated in vivo and in vitro. A considerable loss of nuclear histones, increase of easily extracted arginine-rich histones and a more complete extraction of lysine-rich ones have been shown. A possible role of histones in the development of diphteria intoxication is discussed.
mesh_terms: D000818:Animals; D001120:Arginine; D002467:Cell Nucleus / Q000187:drug effects; D004167:Diphtheria Toxin / Q000494:pharmacology*; D006168:Guinea Pigs; D006657:Histones / Q000302:isolation & purification*; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects*; D008239:Lysine; D011485:Protein Binding / Q000187:drug effects
chemical_list: D004167:Diphtheria Toxin; D006657:Histones; D001120:Arginine; D008239:Lysine
vernacular_title: Vliianie difteriĭnogo toksina na vykhod i ékstragiruemost' gistonov iz iader kletok pecheni morskikh svinok.