title: Synthesis of methyl 1-(3,4-dichlorobenzyl)-hexahydro-2,3-dioxo-4-pyridinecarboxylate.
abstract: Methyl 1-(3,4-dichlorobenzyl)-hexahydro-2,3-dioxo-4-pyridinecarboxylate was prepared by alkylation of methyl hexahydro-2,3-dioxo-4-pyridinecarboxylate with alpha,3,4-trichlorotoluene. The compound showed significant antifungal activity when challenged by a spectrum of pathogenic yeast species in a minimum inhibitory concentration test. It was active against some dermatophytic fungi and Aspergillus niger.
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis*; D002722:Chlorobenzenes / Q000138:chemical synthesis / Q000494:pharmacology; D008722:Methods; D008826:Microbial Sensitivity Tests; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D002722:Chlorobenzenes; D011725:Pyridines