6-Hydroxydopamine reduces preference for conspecific but not other familiar odors in rat pups.
Rat pups injected subcutaneously with 6-hydroxydopamine (6-OHDA) showed reduced preference for a familiar combination of conspecific and botanical odors when subsequently tested in a two-choice situation. However, drug treatment did not influence preference for the simple botanical odor. 6-OHDA also reduced norepinephrine (NE) concentrations in the forebrain and the olfactory bulbs. The data implicate NE in the ontogeny of the acquired responses to conspecific odors.
D000375:Aging; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D002755:Choice Behavior / Q000187:drug effects*; D004837:Epinephrine / Q000032:analysis; D006892:Hydroxydopamines / Q000494:pharmacology*; D009812:Odorants; D051381:Rats
D006892:Hydroxydopamines; D004837:Epinephrine