title: Slow build-up of optokinetic nystagmus associated with downbeat nystagmus.
abstract: Eye movement recordings in two patients with downbeat nystagmus demonstrated an unusual finding of severely impaired smooth pursuit and relatively unimpaired optokinetic nystagmus (OKN). OKN was characterized by a remarkable, slow build-up of slow-component velocity, similar to that found in afoveate animals. Optokinetic after-nystagmus (OKAN), or transient persistence of nystagmus after cessation of visual stimulation, typical of the optokinetic response of normal human subjects, was also preserved in these patients. These observations suggest that the normal contribution of smooth pursuit to the ocular motor response to rotation of the visual environment can be selectively removed by a lesion at the level of the craniocervical junction.
mesh_terms: D000328:Adult; D001139:Arnold-Chiari Malformation / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D001927:Brain Diseases / Q000150:complications*; D004172:Diplopia / Q000150:complications; D004244:Dizziness / Q000150:complications; D004585:Electrooculography; D005133:Eye Movements; D005260:Female; D006801:Humans; D008875:Middle Aged; D009759:Nystagmus, Pathologic / Q000150:complications* / Q000503:physiopathology; D012438:Saccades