A study of HLA antigen distribution in families with atopic dermatitis.
Seventeen children presenting with atopic dermatitis were HLA typed together with their parents and siblings. A total of 89 individuals was studied. No close link between HLA antigen distribution and clinical expression of atopy was demonstrated, and 14 HLA identical but disease-free siblings were identified. An increase in the A1 B8 haplotype was observed in the families as a whole by comparison with a large control series.
D000328:Adult; D002648:Child; D003876:Dermatitis, Atopic / Q000235:genetics* / Q000276:immunology; D005260:Female; D005838:Genotype; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D008297:Male
D006680:HLA Antigens; D007073:Immunoglobulin E