[Interactions between macromolecular adjuvants and drugs. Part 17: On the effect of macromolecular adjuvants on the dissolution rate of chlorpromazine from dosage forms (author's transl)].
The determination of the dissolution rate of chlorpromazine from tablets and triturations containing macromolecular adjuvants by means of a modification of the flow-through type cell according to Langenbucher evidenced a decrease in the dissolution rate produced by polyvinylpyrrolidone, methyl-cellulose and hydroxyethyl-cellulose. It was found that the decrease in the dissolution rate is not due to the confirmed, relatively marked tendency of chlorpromazine to form complexes, but to gel formation.
D000277:Adjuvants, Pharmaceutic; D002482:Cellulose; D002746:Chlorpromazine; D007700:Kinetics; D046911:Macromolecular Substances; D011205:Povidone; D012995:Solubility; D013607:Tablets; D013997:Time Factors; D014783:Viscosity
D000277:Adjuvants, Pharmaceutic; D046911:Macromolecular Substances; D013607:Tablets; D002482:Cellulose; D011205:Povidone; D002746:Chlorpromazine
Wechselwirkungen zwishchen makromolekularen Hilfsstoffen und Arzneistoffen 17. Mitteilung: Zum Einfluss von makromolekularen Hilfsstoffen auf die Auflösungsgeschwindigkeit des Chlorpromazins aus Arzneiformen.