title: Mianserin potentiates responses to acetylcholine in the rat anococcygeus muscle.
abstract: In the rat anococcygeus muscle, mianserin (1 and 10 muM) increased the magnitude of the maximal contractile responses to acetylcholine and carbamylcholine without affecting the maximal responses to (--)-noradrenaline. The potentiating effect of mianserin on responses to acetylcholine was maintained in the presence of 5muM phentolamine, following 6-hydroxy dopamine incubation of the tissues (1 mM for 3h) and in the presence of 1 muM nortriptyline. It is suggested that mianserin increases the sensitivity to acetylcholine by an action at the level of, or distal to, the cholinergic receptor.
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D003984:Dibenzazepines / Q000494:pharmacology*; D004357:Drug Synergism; D006892:Hydroxydopamines / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D008803:Mianserin / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D009661:Nortriptyline / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D051381:Rats
chemical_list: D003984:Dibenzazepines; D006892:Hydroxydopamines; D008803:Mianserin; D002217:Carbachol; D009661:Nortriptyline; D000109:Acetylcholine; D009638:Norepinephrine; D010646:Phentolamine