In vitro and in vivo stability of anthramycin-DNA conjugate and its potential application as an anthramycin prodrug.
D000818:Animals; D000876:Anthramycin / Q000008:administration & dosage* / Q000378:metabolism* / Q000494:pharmacology; D001570:Benzodiazepinones / Q000008:administration & dosage* / Q000378:metabolism*; D002460:Cell Line; D004247:DNA / Q000008:administration & dosage* / Q000378:metabolism; D018736:DNA Adducts; D004260:DNA Repair / Q000187:drug effects; D004338:Drug Combinations; D005347:Fibroblasts; D006801:Humans; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy; D009691:Nucleic Acid Denaturation; D012890:Sleep / Q000187:drug effects; D014018:Tissue Distribution
D001570:Benzodiazepinones; D018736:DNA Adducts; D004338:Drug Combinations; C020204:anthramycin-DNA; D000876:Anthramycin; D004247:DNA