title: Corneal staining subsequent to sequential fluorescein instillations.
abstract: Liquid fluorescein (2%) was instilled into the inferior cul-de-sac and the precorneal tear film and the cornea were observed utilizing a specialized examination routine. Following the initial fluorescein instillation and observations, sequential fluorescein instillations were performed at five-minute intervals six additional times. The incidence of corneal staining (200 corneas) following the initial instillation of fluorescein was 19%. An additional 23% exhibited staining as a result of the sequential staining process. Five types of staining were classified; the most common forms were those associated with the lid margins. Severe degrees of staining appear to be clinically significant, as suggested by a correlation between severe degrees of staining and contact lens intolerance.
mesh_terms: D003261:Contact Lenses / Q000009:adverse effects*; D003315:Cornea / Q000473:pathology*; D005452:Fluoresceins / Q000008:administration & dosage*; D006801:Humans; D013997:Time Factors
chemical_list: D005452:Fluoresceins