An objective comparison of the effects of parenterally administered drugs in patients suffering from detrusor instability.
Cystometric changes produced by 3 parenterally administered drugs, flavoxate hydrochloride, emepronium bromide and imipramine hydrochloride, have been evaluated in 15 female patients with detrusor instability. Each patient was given 2 of the 3 drugs and cystometric recordings were done 10 and 30 minutes after the administration of each drug. Emepronium bromide was found to be the only drug to cause a significant improvement in bladder capacity and reduction in detrusor pressure.
D000328:Adult; D000368:Aged; D004629:Emepronium / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005419:Flavonoids / Q000627:therapeutic use*; D005422:Flavoxate / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007099:Imipramine / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D000644:Quaternary Ammonium Compounds / Q000627:therapeutic use*; D001743:Urinary Bladder / Q000187:drug effects; D014555:Urination Disorders / Q000188:drug therapy*
D005419:Flavonoids; D000644:Quaternary Ammonium Compounds; D004629:Emepronium; D005422:Flavoxate; D007099:Imipramine