title: [Use of substances modifying serotonin metabolism in the treatment of narco-cataplexy (considerations on 5 cases)].
abstract: The AA., after a critical analysis of the new proposed treatments for the narco-cataplexy, report their experience about the therapeutic possibilities of this syndrome with particular manipulations of cerebral serotonin (5-HT). In 5 patients they tried to act on the two sides of the sleeping-waking cycle by using a diurnal administration of Methysergide (5-HT inhibitor) and an evening loading of L-Tryptophan combined with Benserazide (dopa-decarboxilase inhibitor). The immediate and long term results on the nercoleptic as well as cataplectic symptoms can be considered good. Conversely treatments with Clomipramine alone exerted poor beneficial effects in these patients. The AA. discuss the physiopathogenetic mechanisms which are thought to be involved in this disease.
mesh_terms: D000328:Adult; D001545:Benserazide / Q000627:therapeutic use*; D002385:Cataplexy / Q000188:drug therapy* / Q000378:metabolism; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006834:Hydrazines / Q000627:therapeutic use*; D008297:Male; D008784:Methysergide / Q000627:therapeutic use*; D009290:Narcolepsy / Q000188:drug therapy* / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism*; D014364:Tryptophan / Q000627:therapeutic use*
chemical_list: D006834:Hydrazines; D012701:Serotonin; D001545:Benserazide; D014364:Tryptophan; D008784:Methysergide
vernacular_title: L'uso di sostanze modificanti il metabolismo della serotonina nel trattamento della narco-cataplessia (considerazioni su 5 casi).