Porphyrin-inducing activity of alfaxolone and alfadolone acetate in chick embryo liver cells.
The two steroid components of Alfathesin, alfaxolone and alfadolone acetate, have been tested for porphyrin-inducing activity in chick embryo liver cell culture and for hepatic ALA-synthetase-inducing activity in the 17-day-old chick embryo. In cell culture alfoxolone was shown to have potency comparable to that of thiopental, while alfadolone acetate had low potency. In the 17-day-old chick embryo alfaxolone has a third the potency of thiopental; alfadolone acetate showed low potency. The authors conclude that an induction dose of Alfathesin would be less likely than a comparable dose of thiopental to increase ALA-synthetase activity in a patient with hereditary hepatic porphyria.
D000530:Alfaxalone Alfadolone Mixture / Q000494:pharmacology*; D000502:Allylisopropylacetamide / Q000494:pharmacology; D000818:Animals; D002642:Chick Embryo; D006418:Heme / Q000096:biosynthesis; D008099:Liver / Q000187:drug effects*; D011166:Porphyrins; D011277:Pregnanediones / Q000494:pharmacology*; D013874:Thiopental / Q000494:pharmacology
D011166:Porphyrins; D011277:Pregnanediones; D000502:Allylisopropylacetamide; D006418:Heme; D000530:Alfaxalone Alfadolone Mixture; D013874:Thiopental