Unconjugated hyperbilirubinemia during treatment with chenodeoxycholic acid.
The authors describe a slight but significant increase in the serum levels of indirect-reacting bilirubin in gallstone patients after 3 and 6 mo of treatment with chenodeoxycholic acid. A return to pretreatment values was noted at 9 mo. The mechanism of this abnormality remains unclear. Two explanations are theoretically possible: a subclinical hemolysis or a modification of the hepatic transport and/or the conjugation of bilirubin.
D002635:Chenodeoxycholic Acid / Q000009:adverse effects* / Q000627:therapeutic use; D002769:Cholelithiasis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D006932:Hyperbilirubinemia / Q000139:chemically induced*; D008297:Male; D013997:Time Factors
D002635:Chenodeoxycholic Acid