title: Synthesis of 3-hydroxy-3-phenacyloxindole analogs.
abstract: Substituted isatins and substituted acetophenones were condensed to give analogs of 3-hydroxy-3-phenacyloxindole. These alcohols were dehydrated, and the alkene was reduced. None of the products had the level of anticonvulsant activity exhibited by the parent compound.
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis; D004597:Electroshock; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D000078183:Oxindoles; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D010648:Phenylacetates / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D000927:Anticonvulsants; D007211:Indoles; D000078183:Oxindoles; D010648:Phenylacetates; C019188:3-hydroxy-3-phenacyloxindole; D010433:Pentylenetetrazole