Thyroid hormone influence on the susceptibility of mice to audiogenic seizures.
Serum thyroxine levels peak earlier and are significantly higher in audiogenic seizure-susceptible DBA/2J mice than in seizure-resistant C57BL/6J mice during early postnatal life. The seizure susceptibility of DBA/2J mice is suppressed by administration of an antithyroid drug or by radiothyroidectomy, while the seizure susceptibility of C57BL/6J mice is enhanced by treatment with excess thyroxine.
D000161:Acoustic Stimulation; D000818:Animals; D006980:Hyperthyroidism / Q000097:blood; D007037:Hypothyroidism / Q000097:blood; D051379:Mice; D008815:Mice, Inbred Strains; D011441:Propylthiouracil; D012640:Seizures / Q000097:blood*; D013974:Thyroxine / Q000097:blood* / Q000494:pharmacology
D011441:Propylthiouracil; D013974:Thyroxine