Prospective chromosomal study of 30 patients undergoing 90Y synovectomy.
Chromosome studies were performed on 30 patients undergoing 90Y synovectomy before and after therapy. It was observed that overall there was a small but significant rise from 0.33% to 0.87% in the frequency of cells with specific chromosome aberrations following treatment. These findings agree well with those of other surveys. Analysis of individual results show that, of the 30 patients, only 10 showed chromosome damage that could be attributed unequivocally to the 90Y therapy.
D002869:Chromosome Aberrations; D002908:Chronic Disease; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure; D011446:Prospective Studies; D013585:Synovitis / Q000235:genetics / Q000532:radiotherapy*; D015021:Yttrium Radioisotopes / Q000009:adverse effects* / Q000627:therapeutic use
D015021:Yttrium Radioisotopes