title: Synthesis of iodine-131 labeled 6 beta-iodomethyl-19-norsitost-5(10)-en-3 beta-ol and 19-iodositost-5-en-3 beta-ol for adrenal imaging.
abstract: 6 BETA-Iodomethyl-19-norsitost-5(10)-en-3 beta-ol (V) was synthesized by homoallylic rearrangement of 19-iodositost-5-en-3 beta-ol (IV), which was obtained by the hydrolysis of 19-iodositost-5-en-3 beta-ol acetate (III) derived from the displacement of sitost-5-ene-3 beta, 19-diol 3-acetate 19-p-toluenesulfonate (I) with sodium iodide in isopropanol. The radioiodinated IV and V were prepared by isotope exchange with sodium iodide-I-131.
mesh_terms: D000311:Adrenal Glands / Q000000981:diagnostic imaging; D007457:Iodine Radioisotopes; D008722:Methods; D011859:Radiography; D012855:Sitosterols / Q000138:chemical synthesis*
chemical_list: C019437:6 beta-iodomethyl-19-norsitost-5(10)-en-3 beta-ol; D007457:Iodine Radioisotopes; D012855:Sitosterols; C008153:19-iodositosterol