No elevated sister chromatid exchange in Alzheimer's disease.
Chromosomal abnormalities have been reported earlier in Alzheimer-type dementia. Sister chromatid exchange (SCE) was studied in four patients with Alzheimer's disease and five control subjects. The sensitive method to detect chromosomal damage showed no elevated number of SCEs in Alzheimer's disease.
D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics*; D002478:Cells, Cultured; D002842:Chromatids / Q000648:ultrastructure*; D003704:Dementia / Q000235:genetics*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure; D008297:Male; D008677:Metaphase; D008875:Middle Aged