Effect of Nocardia rubra cell-wall skeleton on the induction of lung cancer in ACI/N rats.
Administration of oil-attached Nocardia rubra cell-wall skeleton (N. rubra-CWS) was evaluated for the effect of the induction of lung cancers in ACI/N rats. Lung cancers were induced by 15 weekly intratracheal instillations of 3 mg benzo[a]-pyrene with 3 mg ferric oxide. After the 10th instillation of the carcinogen, rats received seven subcutaneous injections of 100 microgram of N. rubra-CWS at 2-week intervals. In the observation period of 56 weeks, the cumulative incidence of lung cancer was 71.4% in the control group and 48.0% in the N. rubra-CWS treated group. The latent period of tumor induction was prolonged in the group treated with N. rubra-CWS.
D000818:Animals; D001580:Benzopyrenes; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced* / Q000276:immunology / Q000517:prevention & control; D002473:Cell Wall / Q000276:immunology; D005354:Fibrosarcoma / Q000139:chemically induced* / Q000276:immunology; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000276:immunology / Q000517:prevention & control; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control; D009615:Nocardia / Q000276:immunology*; D051381:Rats; D011912:Rats, Inbred ACI
D001580:Benzopyrenes