title: A natural outbreak of transmissible murine colonic hyperplasia in A/J mice.
abstract: Transmissible murine colonic hyperplasia was diagnosed in 6-month-old A/J mice kept under standard laboratory conditions. Bacterial cultures revealed the presence of Citrobacter freundii (4280). Clinical signs included rough coats, feces adhering to the anus, slight dehydration and rectal prolapses. A nonclotting sanquinous intestinal fluid and gross colonic thickening were frequently seen at necropsy. Morbidity was approximately 50%; mortality approximately 25%. Tetracycline appeared to be effective in controlling the disease.
mesh_terms: D000818:Animals; D003108:Colonic Diseases / Q000175:diagnosis / Q000209:etiology / Q000662:veterinary*; D004756:Enterobacteriaceae Infections / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D005260:Female; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D012376:Rodent Diseases / Q000175:diagnosis* / Q000188:drug therapy; D013752:Tetracycline / Q000627:therapeutic use
chemical_list: D013752:Tetracycline