title: Lack of ozone effects on oxygen hemoglobin affinity.
abstract: Ozone exposure has been shown to cause erythrocyte damage and thus may be affecting oxygen delivery by the red cell. Oxyhemoglobin affinity, heme-oxygen binding site interaction (Hill coefficient), and red cell 2,3-diphosphoglycerate concentrations were measured in a total of twenty-two New Zealand white rabbits exposed to ozone. Ozone exposures of 1 and 3 ppm for 4 hr in rabbits had no significant (P greater than .05) effect, immediate or delayed, on the parameters measured.
mesh_terms: D000818:Animals; D001665:Binding Sites / Q000187:drug effects; D004163:Diphosphoglyceric Acids / Q000097:blood; D004912:Erythrocytes / Q000032:analysis; D006418:Heme / Q000378:metabolism; D008297:Male; D010100:Oxygen / Q000097:blood; D010108:Oxyhemoglobins / Q000378:metabolism*; D010126:Ozone / Q000009:adverse effects*; D010313:Partial Pressure; D011817:Rabbits
chemical_list: D004163:Diphosphoglyceric Acids; D010108:Oxyhemoglobins; D006418:Heme; D010126:Ozone; D010100:Oxygen