The metabolic fate of N-isopropyl-N-phenyloxamic acid in the rat and the milk goat.
Rats excreted the 14C from a single oral dose of N-isopropyl-N-[14C]phenyloxamic acid [I, a soil metabolite from 2-chloro-N-isopropylacetanilide (propachlor)] in approximately equal quantities in the urine (49.2%) and feces (48.2%). A milking goat given daily oral doses of [14C]-I (1 mg of I three times daily) excreted more 14C in the feces (56.6%) than it excreted in the urine. From both species, I accounted for 97 to 100% of the urinary 14C, and all of the 14C that was extractable from the feces (73 to 75% of the 14C in feces was extractable with methanol). Goat milk samples collected 16 hr after the last dose contained no detectable 14C. Tissue residues of 14C were determined.
D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D001711:Biotransformation; D005260:Female; D006041:Goats; D010072:Oxamic Acid / Q000031:analogs & derivatives / Q000378:metabolism* / Q000652:urine; D051381:Rats; D013045:Species Specificity; D013997:Time Factors; D014018:Tissue Distribution
D000596:Amino Acids; D010072:Oxamic Acid