Use of hyaluronidase in the central nervous system.
Hyaluronidase, an enzyme which depolymerizes the mucopolysaccharide hyaluronic acid, appears to be tolerated by the human central nervous system and in the anterior chamber of the rabbit eye. Two patients with hydrocephalus and meningomyelocele had their condition curtailed by intraventricular injections of hyaluronidase, and in a third patient its use permitted delay of shunting. It was apparently effective in preventing a reaccumulation of cystic fluid in an intramedullary neurofibroma, and in reversing adverse effects of adhesive arachnoiditis of the spinal cord. Hylauronidase seems worthy of further investigation in disorders of the central nervous system.
D000328:Adult; D000368:Aged; D001100:Arachnoiditis / Q000188:drug therapy; D002493:Central Nervous System Diseases / Q000188:drug therapy*; D005260:Female; D006801:Humans; D006821:Hyaluronoglucosaminidase / Q000008:administration & dosage / Q000627:therapeutic use*; D006849:Hydrocephalus / Q000188:drug therapy; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008591:Meningomyelocele / Q000188:drug therapy / Q000601:surgery; D009442:Neurilemmoma / Q000188:drug therapy / Q000601:surgery; D013120:Spinal Cord Neoplasms / Q000188:drug therapy / Q000601:surgery
D006821:Hyaluronoglucosaminidase