Evidence for natural antibodies (IgG) to polyamines in human sera.
Human sera contain IgGs that react with latex-putrescine spheres. Identification of the IgGs has been achieved by polyacrylamide gel electrophoresis and their reaction with peroxidase-labeled antihuman gamma-chain-specific antibodies. The inhibition of IgG fixation to latex-putrescine spheres by free spermine and putrescine provides evidence that these IgGs are specific for polyamines.
D000918:Antibody Specificity; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007113:Immunity, Innate; D007074:Immunoglobulin G / Q000032:analysis*; D009369:Neoplasms / Q000276:immunology / Q000378:metabolism; D011073:Polyamines / Q000276:immunology* / Q000378:metabolism; D011700:Putrescine / Q000276:immunology; D013096:Spermine / Q000276:immunology
D007074:Immunoglobulin G; D011073:Polyamines; D013096:Spermine; D011700:Putrescine