title: Residues of carcinogenic animal drugs in food: difficulties in evaluation of human safety.
abstract: The indisputable need to intensify animal production in order to provide an adequate food supply for the world population involves the use of substances that are highly potent pharmacologically and toxicologically. The history of regulatory action with regard to such additives is similar to that for other substances: first, no regulation; next, an over-reaction; and now decisions based on judicious evaluation of scientific facts. One factor that differentiates the chemicals used in animal production from other food additives is that both the parent compounds and their metabolites appear in edible products, posing problems both for the analytical detection and safety evaluation of such residues. It would be unrealistic to propose 'zero' tolerances for these additives, even if they are carcinogenic. The benefits gained from drugs that cure and prevent infections and parasitic diseases in food-producing animals, and the fact that analytical methods can now detect very small quantities make the presence of low levels of these substances in food unobjectionable.
mesh_terms: D000821:Animal Feed / Q000009:adverse effects; D000822:Animal Husbandry; D000818:Animals; D002273:Carcinogens; D005503:Food Additives / Q000494:pharmacology; D005504:Food Analysis / Q000592:standards; D005506:Food Contamination / Q000032:analysis* / Q000517:prevention & control; D006801:Humans
chemical_list: D002273:Carcinogens; D005503:Food Additives