Cholinesterase in the atherosclerotic intima and in fibroblast cultures.
Cholinesterase activity was present in the atheromatous plaque of the rabbit's atherosclerotic aorta. Cholinesterase activity was significantly increased in rat fibroblast cultures grown in the presence of hypercholesterolemic serum. Cholesterol ester synthesis in these cultures was inhibited by neostigmine, a cholinesterase inhibitor.
D000818:Animals; D001161:Arteriosclerosis / Q000201:enzymology*; D001769:Blood; D002478:Cells, Cultured; D002788:Cholesterol Esters / Q000096:biosynthesis; D002802:Cholinesterases / Q000378:metabolism*; D003470:Culture Media; D006937:Hypercholesterolemia / Q000097:blood; D009388:Neostigmine / Q000494:pharmacology; D011817:Rabbits; D051381:Rats
D002788:Cholesterol Esters; D003470:Culture Media; D009388:Neostigmine; D002802:Cholinesterases