Influence of epinephrine and propranolol on transmembrane K transfer in anuric dogs with hyperkalemia.
In anuric dogs K loaded by infusion of 2 mEq of KCl per kg per hr the quantity of K transferred to intracellular fluid in ureter-ligated animals is considerably less than in nephrectomized ones; the combination of ureter ligation and hyperkalemia seems to suppress transmembrane K transfer. In the present investigation we found that treatment of K loaded ureter-ligated dogs with epinephrine markedly increased the animals' ability to transfer K to intracellular fluid, and that administration of propranolol (with and without epinephrine) reduced K transfer capacity below the control level. Further, we found that propranolol treatment of K-loaded nephrectomized dogs produced a striking diminution of K transfer ability. The data suggest that beta adrenergic receptors are importantly involved in the transmembrane K transfer of K-loaded anuric dogs, and that ureter ligation and hyperkalemia suppress K transfer capacity by blocking beta receptors.
D000818:Animals; D001002:Anuria / Q000150:complications / Q000378:metabolism*; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D004285:Dogs; D004347:Drug Interactions; D004837:Epinephrine / Q000494:pharmacology*; D005260:Female; D006947:Hyperkalemia / Q000150:complications / Q000378:metabolism*; D008026:Ligation; D008297:Male; D009392:Nephrectomy; D010180:Pancreatectomy; D011188:Potassium / Q000378:metabolism*; D011433:Propranolol / Q000494:pharmacology*; D014513:Ureter / Q000502:physiology
D011433:Propranolol; D011188:Potassium; D004837:Epinephrine