[Effect of phenobarbital on the embryotoxic action of 2-methyl-4-chlorophenoxyacetic acid].
Single administration of 2-methyl-4-chlorophenoxyacetic acid (2M-4C) to albino rats on the 9th and 10th day of gestation produces a teratogenic and embryotoxic action. A preliminary administration of phenobarbital in a dose of 80 mg/kg for 3 days largely reduced the embryotoxic effect of the drug, this manifesting itself in a lower general embryonal and post-implantation mortality, greater size and mass of the fetuses. It is suggested that the stimulation of the microsomal oxidation with phenobarbital led to a higher speed of the 2M-4C molecule decomposition and, consequently, to its lessened embryotoxic effect.
D008456:2-Methyl-4-chlorophenoxyacetic Acid / Q000037:antagonists & inhibitors*; D000014:Abnormalities, Drug-Induced / Q000517:prevention & control*; D000818:Animals; D005260:Female; D005313:Fetal Death / Q000517:prevention & control*; D005327:Fetal Resorption / Q000517:prevention & control; D006016:Glycolates / Q000037:antagonists & inhibitors*; D010634:Phenobarbital / Q000494:pharmacology*; D011247:Pregnancy; D013723:Teratogens / Q000037:antagonists & inhibitors*
D006016:Glycolates; D013723:Teratogens; D008456:2-Methyl-4-chlorophenoxyacetic Acid; D010634:Phenobarbital
Vliianie fenobarbitala na émbriotoksicheskoe deĭstvie 2-metil-4-khlorfenoksiuksusnoĭ kisloty.