title: Suppressive effects of indomethacin on thermally induced neovascularization of rabbit corneas.
abstract: In 16 rabbits with bilateral corneal burns, indomethacin was administered topically to one eye on each day after the lesion was made to determine the effect of a prostaglandin inhibitor on the corneal neovascular response to experimental thermal burns. Comparison of the two eyes showed a reduction of both hyperemia and neovascularization in indomethacin-treated eyes during the first five days after injury. Histologic observations during this period showed a reduction in polymorphonuclear cell infiltration in the treated corneas. Inhibition of prostaglandin synthesis by indomethacin apparently led to a reduction in the inflammatory response and the subsequent corneal neovascularization.
mesh_terms: D000818:Animals; D002196:Capillaries / Q000187:drug effects; D003315:Cornea / Q000098:blood supply / Q000187:drug effects* / Q000503:physiopathology; D005126:Eye Burns / Q000188:drug therapy* / Q000503:physiopathology; D006940:Hyperemia / Q000188:drug therapy / Q000503:physiopathology; D007213:Indomethacin / Q000494:pharmacology / Q000627:therapeutic use*; D011448:Prostaglandin Antagonists / Q000494:pharmacology; D011817:Rabbits; D014945:Wound Healing / Q000187:drug effects
chemical_list: D011448:Prostaglandin Antagonists; D007213:Indomethacin