title: Infection of glutaraldehyde-preserved porcine valve heterografts.
abstract: Gross, histologic and ultrastructural changes associated with bacterial infection are described in four porcine valve heterografts that had been in place in patients for 6 days to 28 months. In one patient, culture of the aortic tissue tag included in the heterograft container grew Mycobacterium chelonei; however, examination of the heterograft, recovered at necropsy 6 days after implantation, revealed small colonies of bacteria that differed morphologically from mycobacteria. A second heterograft was the site of staphylococcal infection associated with extensive destruction of collagen in the leaflets. Similar destruction was observed in a third heterograft, which was found to have organisms on ultrastructural study even though bacterial cultures of the valve were negative. The fourth heterograft, from a patient who died of coronary embolism secondary to dislodgment of vegetative material, contained structures resembling lysed bacteria. Observations in these 4 patients and review of published reports of infection involving 43 other patients with porcine valve heterografts indicates that infection in these valves: (1) develops in the fibrin layer that covers the cusps, (2) can involve the collagen in the leaflets, and (3) is uncommonly (three patients) associated with valve ring abscesses.
mesh_terms: D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000382:microbiology / Q000473:pathology; D001705:Bioprosthesis / Q000009:adverse effects*; D003094:Collagen; D005260:Female; D006349:Heart Valve Diseases / Q000382:microbiology / Q000473:pathology; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006351:Heart Valves / Q000382:microbiology / Q000473:pathology / Q000648:ultrastructure; D006801:Humans; D008297:Male; D008875:Middle Aged; D013203:Staphylococcal Infections / Q000473:pathology; D013210:Staphylococcus / Q000648:ultrastructure
chemical_list: D003094:Collagen