title: Shock and resuscitation. III. Accurate refractometric COP determinations in hypovolemia treated with HALFD.
abstract: In 38 critically burned patients with symptomatic hypovolemia being treated by intravenous fluids, the accuracy of colloid oncotic pressure (COP) calculated from the refractometrically-determined serum total protein (TPRI) was compared with COP values determined by a commercially-available clinical oncometer. Sera were obtained randomly from seven patients receiving Ringer's lactate solution, five receiving a hypertonic solution (240 mOsm Na+) and 26 receiving a hypertonic solution containing albumin (12.5 gm/liter, HALFD method). There was poor correlation between COP measure and that calculated from RI in patients receiving colloid-free fluid, but high correlation (r = 0.925) in patients receiving HALFD. There was high correlation (r = 0.951) between measured COP and values calculated from TPRI in patients receiving hypertonic fluid, colloid containing hypertonic fluid, or no fluid:COP = 4.08 (TPRI)--4.61.
mesh_terms: D002056:Burns / Q000628:therapy; D003102:Colloids / Q000032:analysis*; D005440:Fluid Therapy; D006801:Humans; D006982:Hypertonic Solutions; D008722:Methods; D009997:Osmotic Pressure; D012769:Shock / Q000097:blood / Q000628:therapy*
chemical_list: D003102:Colloids; D006982:Hypertonic Solutions