Effect of levamisole on the auto-antibody formation in nude mice.
The effects of levamisole on the formation of antibody to double-stranded DNA (ds-DNA), an auto-antibody, and to some thymus-dependent antigens were studied in nude (nu/nu) mice. The antibody titre to ds-DNA in nu/nu mice treated with levamisole was lower than that in control animals. The number of Thy-1-antigen-positive (Thy-1+) cells in the spleen from nu/nu mice treated with levamisole was higher than that from non-treated animals. It is suggested that the Thy-1+ cells were induced by levamisole in nu/nu mice and these cells suppressed the formation of antibody to ds-DNA, whereas the formation of antibody to a DNP-conjugate (OVA) and SRBC, thymus-dependent antigens, was not evoked in nu/nu mice after the treatment with levamisole.
D000818:Animals; D000917:Antibody Formation; D000941:Antigens; D001323:Autoantibodies; D004247:DNA / Q000276:immunology; D004136:Dinitrobenzenes / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D007073:Immunoglobulin E; D007075:Immunoglobulin M; D007978:Levamisole / Q000494:pharmacology*; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D008819:Mice, Nude; D010047:Ovalbumin / Q000276:immunology; D012756:Sheep
D000941:Antigens; D001323:Autoantibodies; D004136:Dinitrobenzenes; D007075:Immunoglobulin M; D007978:Levamisole; D007073:Immunoglobulin E; D010047:Ovalbumin; D004247:DNA