title: Acute leukemia and preleukemia in eight males in a family: an X-linked disorder?
abstract: Eight males in a family died of acute leukemia or a potentially preleukemic blood disease. Three patients were descendants of a man through his first wife, and the other five through his second wife. The pattern of disease in the family suggests X-linked inheritance through the two wives, although other mechanisms cannot be excluded. No detectable action of environmental leukemogens was observed in this family disorder.
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000368:Aged; D005260:Female; D006801:Humans; D007938:Leukemia / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D011289:Preleukemia / Q000235:genetics*; D012729:Sex Chromosome Aberrations; D014960:X Chromosome