ABO hemolytic disease of the newborn.
The charts of newborn infants with positive direct Coombs' test were studied. Only cases in which the mother's blood was group O and the infant's group A or group B were studied. There was no difference between group A and group B infants in the frequency and severity of the hemolytic process caused by maternal antibodies. In group B infants, monospecific antibodies (anti-B) were associated with more severe hemolytic process than cross-reacting antibodies (anti-A,B). In group A infants there was no difference in the severity of the disease between monospecific antibodies (anti-A) and cross reacting antibodies (anti-A,B). Even though there was no significant difference in the sex distribution of affected infants, there was a higher number of boys in the more severely affected group.
D000017:ABO Blood-Group System; D000906:Antibodies / Q000032:analysis; D001663:Bilirubin / Q000097:blood; D003298:Coombs Test; D004899:Erythroblastosis, Fetal / Q000097:blood* / Q000209:etiology / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D005312:Fetal Blood / Q000032:analysis; D006400:Hematocrit; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D012737:Sex Factors
D000017:ABO Blood-Group System; D000906:Antibodies; D001663:Bilirubin