title: Ultrastructural and electrophysiological features of meningioma whorls in tissue culture.
abstract: Cultured cells derived from a psammomatous meningioma were induced to from whorls in vitro by deprivation of nutrients. The ultrastructural features of desmosomes and junctional complexes were similar to sections from the surgical specimen; also prominent were 9-10 nm cytoplasmic filaments. Microelectrode recording of whorled cells showed a larger resting membrane potential than that of similar isolated meningioma cells in culture. Whorl formation seen in this tumor may be a result of relative nutritional deprivation and the need for metabolic cooperation among tumor cells.
mesh_terms: D002478:Cells, Cultured; D003896:Desmosomes / Q000648:ultrastructure; D006801:Humans; D007365:Intercellular Junctions / Q000648:ultrastructure; D008564:Membrane Potentials; D008577:Meningeal Neoplasms / Q000648:ultrastructure*; D008579:Meningioma / Q000648:ultrastructure*; D008854:Microscopy, Electron