title: A simple test for autonomic neuropathy in juvenile diabetics.
abstract: The reproducibility of a simple method for determining the beat-to-beat variation during maximal respiration (duration of inspiration = duration of expiration = 5 sec), using an ordinary ECG apparatus and a ruler, was tested in 10 normals and 40 insulin-treated diabetics. The results were reproducible and beat-to-beat variation was found to be independent of a 25-minute period of rest. The method was subsequently applied to 126 insulin-treated diabetics and the results are in accordance with previous investigations on cardiac vagal neuropathy. The method is applicable as a clinical routine test for cardiac vagal neuropathy.
mesh_terms: D000328:Adult; D001146:Arrhythmia, Sinus / Q000175:diagnosis; D001341:Autonomic Nervous System / Q000503:physiopathology*; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D003929:Diabetic Neuropathies / Q000175:diagnosis*; D004562:Electrocardiography; D005260:Female; D006321:Heart / Q000294:innervation; D006339:Heart Rate; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D008297:Male; D008722:Methods; D008875:Middle Aged; D012119:Respiration; D014630:Vagus Nerve / Q000503:physiopathology
chemical_list: D007328:Insulin