Lymphocyte fluorescent profiles (LFP): a possible screening technique in neoplasia.
A technique involving fluorescent protein staining and microfluorometry has been developed for measuring the lymphocyte fluorescent profile (LFP) of peripheral blood lymphocytes. In contrast to normal humans who display a regular bell-shaped curve, the profile from patients with cancer is irregular, showing a bimodal distribution of fluorescence, with a significant population of cells fluorescing at a higher relative intensity. It is suggested that this elevation in protein concentration is due to an immune response to the presence of a neoplasm, and thus this technique may prove to be a useful indicator of malignancy.
D000328:Adult; D000368:Aged; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000032:analysis*; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis*; D009369:Neoplasms / Q000032:analysis / Q000175:diagnosis* / Q000517:prevention & control; D013050:Spectrometry, Fluorescence
D009363:Neoplasm Proteins