Prolonging paracervical block anesthesia: addition of dextran to 2-chloroprocaine.
Forty parturient women received paracervical block (PCB) anesthetics during labor with 2-chloroprocaine (2-CP) and epinephrine in either normal saline or dextran. Thirty-six patients were though to have adequate anesthesia. Nineteen patients who recived 2-CP in saline had a mean duration of anesthesia lasting 55.4 min; one fetus developed post-PCB bradycardia. Seventeen patients who received 2-CP in dextran had a mean duration of anesthesia lasting 72.7 min; no fetal bradycardia was observed following PCB. Neonatal depression, expressed by 1 and 5 min Apgar scores below seven, was not observed in either group. The addition of dextran to 2-CP significantly prolongs the duration of PCB anesthesia and does not appear to compromise the fetus. The pain relief provided by a single PCB with 2-CP in dextran is still relatively short and would not persist throughout the active phase of labor in most parturient women.
D000293:Adolescent; D000328:Adult; D000772:Anesthesia, Local / Q000009:adverse effects; D000773:Anesthesia, Obstetrical / Q000009:adverse effects; D000779:Anesthetics, Local / Q000009:adverse effects; D001034:Apgar Score; D003911:Dextrans / Q000009:adverse effects; D004837:Epinephrine; D005260:Female; D005315:Fetal Diseases / Q000139:chemically induced / Q000517:prevention & control; D005318:Fetal Heart / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D010146:Pain / Q000188:drug therapy; D011247:Pregnancy; D011343:Procaine / Q000009:adverse effects / Q000031:analogs & derivatives*; D012965:Sodium Chloride; D013997:Time Factors
D000779:Anesthetics, Local; D003911:Dextrans; D012965:Sodium Chloride; D011343:Procaine; C004616:chloroprocaine; D004837:Epinephrine