Heparinized styrene-butadiene-styrene elastomers.
A heparinized high-strength elastomer has been developed which is potentially useful as a nonthrombogenic vascular prosthesis. A surface hydroxylated styrene-butadiene-styrene (SBS) block copolymer with at least 40% extent of reaction after glow-discharge cleaning was coated with a 20% acetylated polyvinyl alcohol/heparin mixture containing glutaraldehyde and magnesium chloride. After curing at 80 degrees C for 100 min, the polyvinyl alcohol, heparin, and hydroxylated SBS were covalently bound to each other by acetal bridges. The effects of the various substrate and coating parameters were optimized to achieve very strong adhesion between the coating layer and the surface hydroxylated SBS. Heparin was not leached from the surface of the new material using 3M saline at pH 7.4 despite a detection limit of 10(-5) micrograms heparin/cm2 min. Prolonged partial thromboplastin times of greater than 1200 sec were observed (control: PTT = 120 sec). Preliminary ex vivo testing using a simple arteriovenous shunt in the leg of a rabbit showed good thromboresistance. The heparinized SBS shunt chamber remained patent for more than two hours without desorption of heparin. It was concluded that surface hydroxylated SBS heparinized by acetal coupling owed its thromboresistance to the heparin covalently bound to the surface and not to a microenvironment of heparin in solution at the blood/material interface.
D001672:Biocompatible Materials; D001769:Blood; D001807:Blood Vessel Prosthesis; D002070:Butadienes; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004548:Elasticity; D006493:Heparin; D006801:Humans; D006900:Hydroxylation; D010973:Platelet Adhesiveness; D011137:Polystyrenes; D013314:Stress, Mechanical; D013343:Styrenes; D013499:Surface Properties; D013925:Thromboplastin / Q000502:physiology; D013927:Thrombosis / Q000517:prevention & control*
D001672:Biocompatible Materials; D002070:Butadienes; D011137:Polystyrenes; D013343:Styrenes; D006493:Heparin; D013925:Thromboplastin