[Disorders of oxidative deamination of biogenic amines in the myocardium in experimental atherosclerosis].
Statistically significant inhibition of oxidative deamination of several biogenic amines was found in mitochondrial fraction of heart muscle from rabbits and rats with experimental atherosclerosis and hypercholesterolemia, caused by various methods. Sensitivity of oxidative deamination of tryptamine to inhibitory effect of clorgyline (selective inhibitor of mitochondrial monoamine oxidases) was unaltered in rats with experimental hypercholesterolemia. The rate of oxidative deamination of beta-phenyl ethylamine, tryptamine, benzylamine as well as histamine and putrescine was inhibited after treatment of the mitochondrial fragments from healthy rabbit and rat heart muscles with preparations of oxidized linoleic and linolenic acids, concentration of which was increased in tissues under conditions of atherosclerosis.
D000818:Animals; D001596:Benzylamines / Q000378:metabolism; D001679:Biogenic Amines / Q000378:metabolism*; D003010:Clorgyline / Q000494:pharmacology; D003327:Coronary Disease / Q000378:metabolism*; D003641:Deamination; D006632:Histamine / Q000378:metabolism; D006937:Hypercholesterolemia / Q000378:metabolism; D008041:Linoleic Acids / Q000494:pharmacology; D008042:Linolenic Acids / Q000494:pharmacology; D008297:Male; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D009206:Myocardium / Q000378:metabolism*; D010627:Phenethylamines / Q000378:metabolism; D011700:Putrescine / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D012642:Selegiline / Q000494:pharmacology; D014363:Tryptamines / Q000378:metabolism
D001596:Benzylamines; D001679:Biogenic Amines; D008041:Linoleic Acids; D008042:Linolenic Acids; D008996:Monoamine Oxidase Inhibitors; D010627:Phenethylamines; D014363:Tryptamines; D012642:Selegiline; D006632:Histamine; D003010:Clorgyline; D011700:Putrescine
Narushenie okislitel'nogo dezaminirovaniia biogennykh aminov v serdechnoĭ myshtse pri éksperimental'nom ateroskleroze.