Prostaglandins and thromboxanes in burn injury in man.
The main urine metabolite of prostaglandin F2 alpha (5 alpha, 7 alpha-dihydroxy-11-ketotetranor-phostane-1, 16-dioic acid, PGF-metabolite) was determined by mass spectrometry (MS) and radioimmunoassay (RIA) in burned patients treated under routine conditions. The amount of the PGF-metabolite as determined by MS was 130 and 67 microgram/24 h (normal value 24 +/- 17 microgram/24 h) on days 3 and 5 respectively in one patient. In serial determinations using RIA the urine level of the PGF-metabolite was within normal values during the first days and rose to a broad peak 1-4 weeks after the injury. Thromboxane B2 (TXB2) was identified and quantitated in burn blister fluid. The amount of TXB2 was 1.7 ng/ml.
D000328:Adult; D002056:Burns / Q000378:metabolism*; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D008875:Middle Aged; D011460:Prostaglandins F / Q000378:metabolism* / Q000652:urine; D011863:Radioimmunoassay; D013929:Thromboxane B2 / Q000032:analysis / Q000378:metabolism*; D013931:Thromboxanes / Q000378:metabolism*; D013997:Time Factors
D011460:Prostaglandins F; D013931:Thromboxanes; D013929:Thromboxane B2