Normal anterior endoderm corrects the heart defect in cardiac mutant salamanders (Ambystoma mexicanum).
Recessive mutant gene c in axolotl embryos results in an absence of heart function. Normal (+/+) anterior endoderm cultured with mutant (c/c) hearts totally corrects the defect.
D000557:Ambystoma / Q000196:embryology* / Q000235:genetics; D000818:Animals; D046508:Culture Techniques; D004627:Embryonic Induction; D004707:Endoderm / Q000502:physiology; D005808:Genes, Recessive; D006321:Heart / Q000196:embryology*; D009154:Mutation; D009206:Myocardium / Q000648:ultrastructure