The effect of penicillamine on radiation-induced pulmonary lethality in mice.
The collagen inhibitor D-penicillamine was evaluated as a potential radiation reaction preventive agent by studying its effect on deaths attributed to pulmonary damage in mice. Long-term administration of D-penicillamine at a rate of 100 mg/kg/day had no significant effect on the LD50/160 in mice following pulmonary irradiation.
D000818:Animals; D004032:Diet; D008168:Lung / Q000528:radiation effects*; D051379:Mice; D010396:Penicillamine / Q000494:pharmacology*; D011658:Pulmonary Fibrosis / Q000209:etiology / Q000517:prevention & control*; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents; D011878:Radiotherapy / Q000009:adverse effects
D011837:Radiation-Protective Agents; D010396:Penicillamine