Comparison of in vitro effects of normal IgG and of a monoclonal IgG on the rheological behaviour of erythrocytes.
Erythrocyte sedimentation, viscosity, electrophroetic mobility, and osmotic fragility were measured in a study of the rheological behaviour of the erythrocyte in vitro. In comparison with physiological saline solution, a suspending medium containing a gamma2lambda2 monoclonal IgG from a patient with multiple myeloma caused rheological changes 2-3 times as great as a medium with normal IgG. Our results demonstrate the existence of nonimmunological interactions between erythrocytes and normal or monoclonal immunoglobulins, and they raise questions about the widely held assumption that paraproteins are structurally 'normal'.
D001809:Blood Viscosity; D004586:Electrophoresis; D004912:Erythrocytes / Q000502:physiology*; D006461:Hemolysis; D006801:Humans; D007074:Immunoglobulin G; D066298:In Vitro Techniques; D009101:Multiple Myeloma / Q000276:immunology; D009996:Osmotic Fragility; D012212:Rheology
D007074:Immunoglobulin G