Effects of eye removal on receptors of alpha-bungarotoxin in the optic lobes of chick brain.
The existence of receptors with high affinity for alpha-bungarotoxin and the pharmacologic properties of a nicotinic ACh receptor has been shown in the optic tectum of chick brain. In the present study eyes were removed from chicks at embryonic day 3 (E3), or at post-hatching day 3 (P3). In both cases, the total number of receptors for I125-alphaBT which developed in the deafferented optic lobe was about 50% of the number in normal lobes.
D000818:Animals; D002038:Bungarotoxins / Q000378:metabolism*; D002642:Chick Embryo; D003714:Denervation; D005123:Eye / Q000196:embryology*; D009475:Neurons, Afferent; D009899:Optic Lobe, Nonmammalian / Q000032:analysis / Q000196:embryology*; D011955:Receptors, Drug / Q000032:analysis*
D002038:Bungarotoxins; D011955:Receptors, Drug