A specific GT1 ganglioside-luteinizing hormone interaction induces conductance changes in lipid bilayers.
A specific interaction was demonstrated between GT1 gangliosides incorporated in bilayer membranes and luteinizing hormone. This interaction would allow the penetration of a hormone subunit in the membrane. The results are discussed in terms of adenylate cyclase activation.
D000262:Adenylyl Cyclases / Q000378:metabolism; D004553:Electric Conductivity; D004789:Enzyme Activation; D005677:G(M1) Ganglioside / Q000502:physiology; D005732:Gangliosides / Q000502:physiology*; D007986:Luteinizing Hormone / Q000502:physiology*; D008567:Membranes, Artificial
D005732:Gangliosides; D008567:Membranes, Artificial; D005677:G(M1) Ganglioside; D007986:Luteinizing Hormone; D000262:Adenylyl Cyclases