Predictability of warfarin dose requirements: theoretical considerations.
The theoretical basis of the predictability of warfarin maintenance dose requirements was evaluated using computer-generated hypothetical patient responses to a 10-mg/day "loading" dose regimen. Correlations between these responses and projected maintenance dose requirements were evaluated statistically, and a significant relationship was identified.
D004334:Drug Administration Schedule; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D011516:Prothrombin / Q000378:metabolism; D014859:Warfarin / Q000008:administration & dosage* / Q000378:metabolism / Q000494:pharmacology
D014859:Warfarin; D011516:Prothrombin