Adenylate cyclase from human decidua parietalis.
Adenylate cyclase (EC 4.6.1.1) activity was demonstrated in membrane fractions of human decidua parietalis. Adenylate cyclase activity was associated with membrane fractions of decidua but not chorion or amnion. Prostaglandins PGE1 and PGE2 but neither PGD2 nor PGF2 alpha stimulated this activity at gestational ages 18 to 40 weeks. Fluoride and guanosine triphosphate stimulated decidual adenylate cyclase; however, epinephrine-stimulated adenylate cyclase activity was demonstrable only in the presence of guanosine triphosphate. The possible roles of adenylate cyclase activity in the decidua are discussed.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000650:Amnion / Q000201:enzymology; D002823:Chorion / Q000201:enzymology; D003656:Decidua / Q000187:drug effects / Q000201:enzymology*; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000494:pharmacology; D000431:Ethanol / Q000494:pharmacology; D005260:Female; D005459:Fluorides / Q000494:pharmacology; D006160:Guanosine Triphosphate / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D011247:Pregnancy; D011453:Prostaglandins / Q000494:pharmacology
D011453:Prostaglandins; D000431:Ethanol; D006160:Guanosine Triphosphate; D000262:Adenylyl Cyclases; D005459:Fluorides; D004837:Epinephrine