title: Microbiological and pharmacological evaluation, in mice and rats, of a new nitrofuran: 2-amino-4-methyl-6-(2-ethinyl-5-nitrofuryl)-pyrimidine (nifurpyrimidine).
abstract: 2-Amino-4-methyl-6-(2-ethinyl-5-nitrofuryl)-pyrimidine (nifurpyrimidine) is a new furan derivative. Its spectrum of activity is wide and includes both gram-positive and gram-negative microorganisms and fungi; moreover, it inhibits the growth of multiple-drug resistant salmonellae. The minimal inhibitory concentrations ranged from 0.25 to 10 microgram/ml. Resistance was developed in vitro in a step-wise manner and was partially reversed after 7-10 passages in drug-free media. The pharmacological study of the drug was carried out in rats and mice and gave the following results: (1) no acute toxicity was demonstrable following oral administration; (2) no intestinal absorption occurred and virtually the whole dose of nifurpyrimidine administered by oral route was recovered in the intestinal content; (3) the presence of urine, plasma or feces did not modify the antibacterial activity of the compound.
mesh_terms: D000818:Animals; D001419:Bacteria / Q000187:drug effects*; D004353:Drug Evaluation, Preclinical; D004352:Drug Resistance, Microbial; D005658:Fungi / Q000187:drug effects*; D007408:Intestinal Absorption; D051379:Mice; D008826:Microbial Sensitivity Tests; D009581:Nitrofurans / Q000378:metabolism / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats
chemical_list: D009581:Nitrofurans