Carcinogenicity testing for control of environmental tumor development in man.
After briefly reviewing the present status of carcinogenicity testing as an aid to the control of environmental carcinogenesis in man, and discussing in somewhat more detail the relative advantages and limitations of animal testing and the two most widely used short-term assays--the Ames test and in vitro carcinogenesis--special attention is given to two points: 1) the difficulties inherent in extrapolating from the results of experimental tests an index of potential carcinogenic hazards in man; 2) the urgent need for additional testing procedures for the detection of associated factors (such as, cocarcinogenic factors and promoting agents) operating in human carcinogenesis.
D000818:Animals; D002274:Carcinogens, Environmental; D002471:Cell Transformation, Neoplastic; D005188:False Negative Reactions; D005189:False Positive Reactions; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis / Q000517:prevention & control*
D002274:Carcinogens, Environmental