title: [Physicochemical aspects of the mechanism of the mineralization of epiphyseal cartilage in enchondral osteogenesis].
abstract: Mechanism of epiphysial cartliage mineralization is considered in terms of ion exchange concepts. Chondroitin-sulfate of matrix, which is a polyelectrolyte, served as a donor od calcium ions. Pericellular zone of matrix is considered as a semipermeable membrane. The energetic basis of the process is provided by interacellular glycogenolysis in chondrocytes, entering the zone of mineralization. High concentration of glucose in lacunas of chondrocytes led to osmotic transport of water from matrix to lacunas, causing an increase in concentration of ions in free volume of the matrix. Due to ion exchange release of calcium ions occurred from the phase of polyelectrolyte into the free volume, where the state of saturation was achieved and dicalcium phosphate CaHPO4 was precipitated. Stereologic studies of epiphysial cartilage, simulation experiments and calculations corroborate the mechanism of mineralization advanced.
mesh_terms: D001857:Bone Matrix / Q000378:metabolism; D002122:Calcium Chloride / Q000378:metabolism; D002356:Cartilage / Q000378:metabolism*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002809:Chondroitin Sulfates / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004838:Epiphyses / Q000378:metabolism*; D007474:Ion Exchange; D008954:Models, Biological; D010012:Osteogenesis; D012965:Sodium Chloride / Q000378:metabolism; D012996:Solutions
chemical_list: D012996:Solutions; D012965:Sodium Chloride; D002809:Chondroitin Sulfates; D002122:Calcium Chloride
vernacular_title: Fiziko-khimicheskie aspekty mekhanizma mineralizatsii épifizarnogo khriashcha pri énkhondral'nom osteogeneze.