Autoimmune hemolytic anemia associated with IgG auto anti-N.
A second case of autoimmune hemolytic anemia mediated by an IgG auto Anti-N is described. The patient's red blood cells were sensitized with both IgG and complement. The serum antibody was not inactivated by 2-mercaptoethanol treatment, and reacted by indirect antiglobulin test at 37 C with monospecific anti-IgG. The IgG antibody eluted from the red blood cells and in the serum showed anti-N specificity. The patient was thought to have systemic lupus erythematosus. Following steroid therapy, the hemolytic anemia resolved with disappearance of the anti-N.
D000328:Adult; D000744:Anemia, Hemolytic, Autoimmune / Q000150:complications / Q000276:immunology*; D001323:Autoantibodies / Q000032:analysis; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D008180:Lupus Erythematosus, Systemic / Q000150:complications; D008951:MNSs Blood-Group System; D013156:Splenectomy
D001323:Autoantibodies; D007074:Immunoglobulin G; D008951:MNSs Blood-Group System