title: [Vein substitution using PTFE prosthesis--results of animal experiments and initial clinical experiences].
abstract: The expanded PTFE prosthesis (Gore Tex), which has been used for 4 years as an artery substitute, was examined in the "low-pressure system" in dogs. In 23 dogs an infrarenal segment of the vena cava was resected and substituted by a Gore Tex prosthesis. In nine dogs an arteriovenous shunt between the right iliac artery and the corresponding vein was also performed. Phlebographic examinations were made 8 days after the operation and at monthly intervals thereafter. After a mean period of 233 days the dogs were killed and histopathologic and electron microscopic analyses performed. Patency was found in 89% of transplants with, and 86% of transplants without, the arteriovenous shunt. Aafter these experiments the Gore Tex prosthesis was implanted successfully in patients suffering from postthrombotic syndrome to serve as a substitute for the superior vena cava and iliac vein. It also acted as a substitute for the jugular vein after neck dissection.
mesh_terms: D000818:Animals; D001166:Arteriovenous Shunt, Surgical; D001807:Blood Vessel Prosthesis; D004285:Dogs; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007083:Iliac Artery / Q000601:surgery; D007084:Iliac Vein / Q000601:surgery; D007601:Jugular Veins / Q000601:surgery; D008297:Male; D010690:Phlebography; D011138:Polytetrafluoroethylene; D013927:Thrombosis / Q000601:surgery; D014682:Vena Cava, Inferior / Q000601:surgery*; D014683:Vena Cava, Superior / Q000601:surgery
chemical_list: D011138:Polytetrafluoroethylene
vernacular_title: Venenersatz durch PTFE-Prothese--tierexperimentelle Ergebnisse und erste klinische Erfahrungen.