Turtle-dove ovomucoid, a glycoprotein proteinase inhibitor with P1-blood-group antigen activity.
Ovomucoid from the egg white of turtle-dove (Streptopelia risoria) was purified and shown to be a glycoprotein of mol. wt. 29 400, with valine as N-terminal residue. It is an inhibitor of both trypsin and chymotrypsin, but has a lower affinity for trypsin than has hen ovomucoid. Turtle-dove ovomucoid contains antigenic activity cross-reacting with the blood-group-P1 antigen of human erythrocytes. Hen ovomucoid has no detectable blood group-P1 activity. The carbohydrate composition of turtle-dove ovomucoid differs from hen ovomucoid in having substantially higher galactose content. The possible relationship between carbohydrate composition and antigenic activity is discussed.
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D001789:Blood Group Antigens; D002241:Carbohydrates / Q000032:analysis; D002848:Chromatography, DEAE-Cellulose; D002918:Chymotrypsin / Q000037:antagonists & inhibitors; D010856:Columbidae / Q000276:immunology*; D004527:Egg Proteins / Q000276:immunology*; D007525:Isoelectric Focusing; D009439:Neuraminidase; D010059:Ovomucin / Q000276:immunology* / Q000302:isolation & purification / Q000494:pharmacology; D010127:P Blood-Group System; D013056:Spectrophotometry, Ultraviolet; D014361:Trypsin Inhibitors
D000596:Amino Acids; D001789:Blood Group Antigens; D002241:Carbohydrates; D004527:Egg Proteins; D010127:P Blood-Group System; D014361:Trypsin Inhibitors; D010059:Ovomucin; D009439:Neuraminidase; D002918:Chymotrypsin