title: Chlorpromazine treatment of blood-brain barrier dysfunction. A quantitative and fluorescence microscopical study on small cerebral stab wounds in the rat.
abstract: The extravasation of albumin around small cerebral stab wounds in the rat frontal cortex was studied by fluorescence microscopy after i.v. injection of Evans blue-labeled albumin and by quantitative immunoelectrophoresis after i.v. injection of bovine albumin, in both nonintoxicated and ethanol-intoxicated rats. The extravasion of albumin was enhanced in ethanol-intoxicated compared to nonintoxicated rats, as studied both by immunoelectrophoresis and by fluorescence microscopy. Administration of chloropromazine (2 mg/kg body weight i.v.) 16 h after inflicting cerebral stab wounds decreased the area around the wound showing extravasation of Evans blue-labeled albumin as studied by fluorescence microscopy both in nonintoxicated and in ethanol-intoxicated rats. Quantitative studies showed a significanct decrease in the amount of extravasated albumin around cerebral stab wounds in ehtnaol-entoxicated rats, while the extravasation in nonintoxicated rats was not significantly changed by chlorpromizine treatment.
mesh_terms: D000418:Albumins / Q000032:analysis; D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects*; D001930:Brain Injuries / Q000473:pathology*; D002540:Cerebral Cortex / Q000293:injuries; D002746:Chlorpromazine / Q000494:pharmacology*; D000431:Ethanol / Q000494:pharmacology; D005625:Frontal Lobe / Q000293:injuries; D008297:Male; D051381:Rats; D013997:Time Factors
chemical_list: D000418:Albumins; D000431:Ethanol; D002746:Chlorpromazine