Haemostatic factors in Black and White diabetics.
Haemostatic factors in 33 Black and 32 White maturity-onset diabetics were analysed and compared with those in 19 normal Black and 19 White subjects. The Black-White diabetic group comparisons revealed depressed antithrombin (AT) III functional activity, a raised factor VII level and a raised factor V level in females in the White diabetic group. On comparing the White diabetics with their respective controls a rise in factor VIII and fibrinogen activity was demonstrated. These changes are suggestive of a hypercoagulable state in the White maturity-onset diabetic. In contrast, Black diabetics have higher functional AT III levels than their respective controls. This may indicate a protective reaction which would explain in part the reported lower incidence of occlusive vascular disease in this group. Platelet hyperactivity was not demonstrated in the majority of White and Black diabetics. Black diabetics and controls demonstrated higher factor VIII levels than the corresponding White groups, confirming previous observations of raised factor VIII levels among Blacks and suggesting that this feature is a racial characteristic.
D000328:Adult; D000368:Aged; D044383:Black People; D001779:Blood Coagulation Factors / Q000032:analysis*; D001786:Blood Glucose / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D003925:Diabetic Angiopathies / Q000503:physiopathology*; D005169:Factor VIII / Q000032:analysis; D005260:Female; D005340:Fibrinogen / Q000097:blood; D006487:Hemostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D013019:South Africa; D014280:Triglycerides / Q000097:blood; D044465:White People
D001779:Blood Coagulation Factors; D001786:Blood Glucose; D014280:Triglycerides; D005169:Factor VIII; D005340:Fibrinogen; D002784:Cholesterol