title: [The biological effect of purely synthetic human insulin in patients with diabetes mellitus].
abstract: Six patients with diabetes were treated with fully synthetic human insulin (CGP 12 831) for durations of 3 days (4 patients), 4 days and 13 days (1 patient each). In every case, clinical signs of hypoglycemia were registered and measured by blood sugar determinations. Two patients with insulin-dependent diabetes were maintained on synthetic insulin. Ketoacidosis was corrected in 1 patient. In a hyperglycemic diabetic with failing response to oral antidiabetics, synthetic insulin normalized the hyperglycemia. In 2 juveniles with recent onset of diabetes, every injection of synthetic insulin was followed by a fall in blood sugar. In a normal individual, hypoglycemia developed after a single injection of 8 units. The synthetic human insulin was well tolerated. The 6 diabetics showed evidence of full biological action of the fully synthetic insulin, as was expected from animal experiments.
mesh_terms: D000328:Adult; D000368:Aged; D002026:Buformin / Q000627:therapeutic use; D002747:Chlorpropamide / Q000627:therapeutic use; D003920:Diabetes Mellitus / Q000188:drug therapy*; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy; D005260:Female; D006728:Hormones / Q000627:therapeutic use*; D006801:Humans; D007328:Insulin / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged
chemical_list: D006728:Hormones; D007328:Insulin; D002026:Buformin; D002747:Chlorpropamide
vernacular_title: Die biologische Wirkung von vollsynthetischem humanem Insulin bei Patienten mit Diabetes mellitus.