Combined oral L-dopa and propranolol for growth hormone provocation.
A convenient test of growth hormone (GH) provocation using oral doses of L-dopa and propranolol (L + P) is compared with insulin-induced hypoglycemia (IIH) in 28 children and adolescents with short stature. In eight of these children, growth hormone deficiency was diagnosed when GH failed to rise above 7 ng/ml. The GH levels of the remaining GH-responsive children were significantly higher after administration of L + P (P less than .05) when compared with IIH given before L + P on the same morning or on a separate day.
D002648:Child; D013006:Growth Hormone / Q000172:deficiency / Q000378:metabolism*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007003:Hypoglycemia; D007328:Insulin / Q000494:pharmacology; D007980:Levodopa / Q000008:administration & dosage / Q000494:pharmacology*; D011433:Propranolol / Q000008:administration & dosage / Q000494:pharmacology*
D007328:Insulin; D007980:Levodopa; D013006:Growth Hormone; D011433:Propranolol; D006854:Hydrocortisone