title: Self-therapy for haemophilia in Norway. Effect on transfusion frequency and days lost from work.
abstract: During the years 1975--77, 35 patients with haemophilia A or B (factor level of 1% or less) were instructed to administer concentrates of the deficient factor (mean dose 14 U/kg) i.v. in case of episodic, uncomplicated bleedings without prior consultation with a physician. At Dec. 1977, 33 of these patients (29 with haemophilia A, 4 with B) were taking part in the program. They represent 35% of all Norwegian patients above 7 years of age with severe haemophilia in whom high-titered antibodies have not been demonstrated. For 13 patients, records from 2 years on self-therapy have been compared with records from the last year before self-therapy. During the first year on self-therapy the number of days lost from work dropped by 77%, while the number of transfusions increased by 22%. During the second year, days lost from work were still low (68% decrease compared to the year preceding self-therapy) and the transfusion frequency remained unchanged. Significant side-effects of antihaemophilic concentrates were not observed and vein damage was not a problem. Joint motion studies did not indicate progress of haemophilic arthropathy during self-therapy. Properly supervised self-therapy is practical and safe and improves considerably to quality of life.
mesh_terms: D000041:Absenteeism; D000293:Adolescent; D000328:Adult; D001803:Blood Transfusion; D002648:Child; D005069:Evaluation Studies as Topic; D005164:Factor IX / Q000008:administration & dosage* / Q000627:therapeutic use; D005169:Factor VIII / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006467:Hemophilia A / Q000628:therapy*; D002836:Hemophilia B / Q000628:therapy; D006509:Hepatitis B / Q000209:etiology; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006801:Humans; D007275:Injections, Intravenous / Q000009:adverse effects; D008297:Male; D009664:Norway; D010353:Patient Education as Topic; D012646:Self Administration; D013997:Time Factors
chemical_list: D006514:Hepatitis B Surface Antigens; D005169:Factor VIII; D005164:Factor IX