[Role of lipid peroxidation and alpha-tocopherol in the conductivity of model membranes from phospholipids of the liver of rats with burns].
The membrane conductivity for K+ and Ca+2 ions was studied on bilayer phospholipid membranes formed by phospholipids extracted from the rat liver 1 hour, 1, 3, 7, and 15 days after burning. A pronounced increase in the membrane conductivity was noted. The most potent effects were seen by the 1t, 3d and 7th day of the experiment and the conductivity value varied depending on the medium pH. The process was accompanied by lipid peroxidation increase. Intraperitoneal administration of alpha-tocopherol at 1 mg/kg dose immediately after burning, followed by injections on the 3d, 7th and 12th day, normalized the characteristics studied. Bilayer membranes formed by healthy rat liver phospholipids previously added with an appropriate amount of methyl oleate or cumylhydroperoxide demonstrated higher conductivity as compared to the normal.
D000818:Animals; D001692:Biological Transport; D002056:Burns / Q000378:metabolism*; D002463:Cell Membrane Permeability; D008099:Liver / Q000378:metabolism*; D008297:Male; D008567:Membranes, Artificial; D008954:Models, Biological; D010545:Peroxides / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism; D051381:Rats; D012964:Sodium / Q000378:metabolism; D014810:Vitamin E / Q000378:metabolism*
D008567:Membranes, Artificial; D010545:Peroxides; D010743:Phospholipids; D014810:Vitamin E; D012964:Sodium; D011188:Potassium
Rol' lipidnoĭ peroksidatsii i alpha-tokoferola v provodimosti model'nykh membran iz fosfolipidov pecheni krys pri ozhogovoĭ bolezni.