[Gas chromatographic determination of the solubility coefficient for volatile anaesthetics (author's transl)].
For the determination of the solubility coefficient of volatile anaesthetics in Schindler's liquid culture, modified by Karzel, a gas-chromatographic analysis with direct-injection-method was used. A well defined volume with a known concentration of the anaesthetic was added to a vessel with known volume. After equilibration the concentration of the inhalational anaesthetics was determined in the liquid at various temperatures. The solubility coefficient and the temperature coefficient were then calculated from these data. We obtained the following solubility coefficients at -4 degrees C (37 degrees): for halothane 1,07 (0,77), for enflurane 1,14 (0,70), for methoxyflurane 4,92 (3,23) and for isoflurane 1,13 (0,82). In Schindler's liquid culture modified by Karzel the values at 24 degrees (37 degrees) were: for halothane 1,33 (0,92), for enflurane 1,32 (0,87), for methoxyflurane 6,61 (4,48) and for isoflurane 1,19 (0,98). The temperature coefficient for this temperature range were in water (in Schindler's liquid culture) for halothane: -2,31 . 10(-2) K(-1) (-3,15 . 10(-2) K(-1)), for methoxyflurane: -13,0 . 10(-2) K(-1) (-16,48 . 10(-2) K(-1)), for enflurane: -3,38 . 10(-2) K(-1) (-3,46 . 10(-2) K(-1)) and for isoflurane: -2,38 . 10(-2) K(-1) (-1,62 . 10(-2) K(-1)).
D000777:Anesthetics / Q000032:analysis*; D002849:Chromatography, Gas; D004737:Enflurane / Q000032:analysis; D006221:Halothane / Q000032:analysis; D066298:In Vitro Techniques; D007530:Isoflurane / Q000032:analysis; D008733:Methoxyflurane / Q000032:analysis; D012995:Solubility; D013696:Temperature
D000777:Anesthetics; D008733:Methoxyflurane; D004737:Enflurane; D007530:Isoflurane; D006221:Halothane
Gaschromatographische Bestimmung des Verteilungskoeffizienten für volatile Anaesthetika.