[Role of progesterone in the insulin-resistance during pregnancy in the rat (author's transl)].
Progesterone inhibits insulin action in vivo and in vitro. In vivo the hypoglycemic action of an intravenous injection of insulin is counteracted by a simultaneous injection of progesterone. In vitro, insulin effect on glucose uptake and on 14CO2 production from 14C-glucose is inhibited by progesterone in female rat diaphragme muscle, adipose tissue and isolated adipocytes. Thus, progesterone plays an important role in carbohydrate metabolism during pregnancy in the rat.
D000818:Animals; D005260:Female; D005947:Glucose / Q000378:metabolism*; D007329:Insulin Antagonists; D011247:Pregnancy; D011270:Pregnancy, Animal; D011374:Progesterone / Q000494:pharmacology*; D051381:Rats
D007329:Insulin Antagonists; D011374:Progesterone; D005947:Glucose
Rôle de la progestérone dans l'insulino-résistance pendant la gestation chez la rate]