Phototoxicity. The neglected factor.
Ignorance of phototoxicity by the general biomedical community constitutes a health hazard. Certain food colorants and dyes proposed for use in angiography produce lethal effects in cells and whole organisms on light exposure but not in the dark. Yet-light-relatedness is usually neglected in toxicity studies. We urge that the specific involvement of light be considered whenever the toxicity of a light-absorbing substance is assessed.
D000818:Animals; D002273:Carcinogens; D004285:Dogs; D005451:Fluorescein Angiography; D005452:Fluoresceins / Q000009:adverse effects; D005456:Fluorescent Dyes / Q000009:adverse effects; D005505:Food Coloring Agents / Q000009:adverse effects*; D006415:Hematoporphyrins / Q000009:adverse effects; D006801:Humans; D008027:Light / Q000009:adverse effects*; D010787:Photosensitivity Disorders / Q000139:chemically induced
D002273:Carcinogens; D005452:Fluoresceins; D005456:Fluorescent Dyes; D005505:Food Coloring Agents; D006415:Hematoporphyrins