Nerve-growth promoting action of isaxonine in rat.
After sciatic nerve lesion by freezing, the length of the most rapidly regenerating fibres was significantly increased by i.p. injection of isaxonine (N-isopropyl-amino-2-pyrimidine orthophosphate) in the rat. A dose-effect relationship was demonstrated. Both sensory and motor function returned earlier in treated animals.
D000818:Animals; D008297:Male; D009416:Nerve Regeneration / Q000187:drug effects*; D009420:Nervous System / Q000187:drug effects / Q000254:growth & development*; D011743:Pyrimidines / Q000494:pharmacology*; D051381:Rats; D012584:Sciatic Nerve / Q000187:drug effects / Q000254:growth & development; D013268:Stimulation, Chemical; D013997:Time Factors
D011743:Pyrimidines; C020375:isaxonine