title: Genetics of F1 hybrid susceptibility to myeloma grafts.
abstract: The genetics of hybrid susceptibility of parental myeloma transplants in histocompatible F1 hybrids was investigated. Various inbred mouse strains and their descendant congenic lines were crossed with BALB/C mice to produce appropriate F1 hybrids. Genetic inferences were drawn from the comparison of the frequencies of tumor graft takes among congenic combinations. Hybrids containing the C57BL/10 genetic background were less susceptible to myeloma transplants than were hybrids of other genotypes. Both H-2-associated and non-H-2-associated genetic factors played significant roles in determining host susceptibility to the transplants. The D end of the major histocompatibility complex did not play a predominant role in determining hybrid susceptibility in C57BL-derived F1 hybrids.
mesh_terms: D000818:Animals; D006183:H-2 Antigens / Q000235:genetics; D006824:Hybridization, Genetic; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009101:Multiple Myeloma / Q000235:genetics*; D009368:Neoplasm Transplantation; D011995:Recombination, Genetic
chemical_list: D006183:H-2 Antigens