Heparin monitoring and thrombosis.
The activated parial thromboplastin time is susceptible to changing concentrations of factor VII even in the presence of heparin. Heparin delays, but does not abolisn, thrombin generation, and this delay is obviated by factor VIII. It is not known if activated parial thromboplastin time shortened by increased factor VIII demands an increase in heparin administration.
D001777:Blood Coagulation / Q000187:drug effects*; D005169:Factor VIII / Q000494:pharmacology*; D005340:Fibrinogen / Q000494:pharmacology; D006493:Heparin / Q000494:pharmacology* / Q000627:therapeutic use; D013917:Thrombin / Q000378:metabolism; D013925:Thromboplastin; D013927:Thrombosis / Q000188:drug therapy*
D005169:Factor VIII; D005340:Fibrinogen; D006493:Heparin; D013925:Thromboplastin; D013917:Thrombin