Optimum fractionation for irradiation of carcinoma of the bladder. Experiments based on one case.
A patient with multiple metastases of transitional cell carcinoma of the bladder to the skin and subcutaneous tissues proved a model where most of the biologic and host-related factors were constant. The effects of varying the physical factors of radiation dose and time were observed. The results indicate that fractionated irradiation at intervals of 48 h was more effective than at intervals of 24 h and that superfractionation (intervals of 5 h) was not an effective method for the treatment of this tumor. The possible reasons for this effect and the implication for the treatment of bladder carcinoma are discussed.
D002295:Carcinoma, Transitional Cell / Q000532:radiotherapy*; D002470:Cell Survival / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D008875:Middle Aged; D008954:Models, Biological; D009362:Neoplasm Metastasis; D011879:Radiotherapy Dosage; D012878:Skin Neoplasms / Q000532:radiotherapy; D001749:Urinary Bladder Neoplasms / Q000532:radiotherapy*