Inhibition by ether of glucose-stimulated insulin secretion in isolated pieces of rat pancreas.
Addition of glucose (16.7 mM) to isolated pieces of rat pancreas increased insulin secretion 5.4-fold over basal secretion rates. Ether at 1, 1.5 and 2 MAC inhibited this insulinogenic effect of glucose in a dose-related manner by 5, 18 (P less than 0.01) and 29 (P less than 0.01) per cent, respectively.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004986:Ether / Q000494:pharmacology*; D005019:Ethyl Ethers / Q000494:pharmacology*; D005947:Glucose / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D010179:Pancreas / Q000378:metabolism*; D051381:Rats
D005019:Ethyl Ethers; D007328:Insulin; D004986:Ether; D005947:Glucose