Prevention by coenzyme Q10 of the electrocardiographic changes induced by adriamycin in rats.
The administration of adriamycin (ADM) to rats has consistently caused a widening of the QRS complex of the electrocardiogram. When coenzyme Q10 was also administered, beginning two days before ADM, this widening of the QRS complex and the elongation of the Q-T interval were reduced or totally prevented, depending upon conditions. ADM alone or with coenzyme Q10 did not alter the P-R interval. Some control by coenzyme Q10 of the cardiotoxicity of adriamycin in cancer patients is promising.
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000517:prevention & control*; D001835:Body Weight; D004317:Doxorubicin / Q000037:antagonists & inhibitors*; D004562:Electrocardiography; D008297:Male; D051381:Rats; D014451:Ubiquinone / Q000494:pharmacology*
D014451:Ubiquinone; D004317:Doxorubicin