Red cell inclusion bodies in a case of preleukaemia.
A 26-year-old female patient is reported in whom red cell inclusion bodies (Hb-H) and thrombocytopenia appeared more than 5 years before the emergence of atypical chr. myeloid leukaemia. Attention is drawn to the fact that the recently uncovered mechanism of acquisition of Hb-H (absence of transcription of specific genes) has previously been implicated in other biochemical changes typical of leukaemia.
D000328:Adult; D004908:Erythrocyte Inclusions; D005260:Female; D006447:Hemoglobin H / Q000032:analysis; D006801:Humans; D011289:Preleukemia / Q000097:blood* / Q000235:genetics; D013921:Thrombocytopenia / Q000097:blood; D014158:Transcription, Genetic
D006447:Hemoglobin H