title: [Effect of various kanamycin dosage forms in experimental nonpenetrating infected injuries to the cornea].
abstract: Animals with experimental non-penetrating local wound of the cornea of the type of erosion infected with highly virulent strains of Staph. aureus were treated at various periods, i.e. in 15 minutes, 2, 6 and 9 hours with kanamycin solution (10000 gamma/ml) and kanamycin imbibized films. The therapeutic effect of the kanamycin solution on the non-penetrating infected wound of the cornea was higher when the treatment was started at earlier periods after infection with Staph. aureus. At later periods when the inflammatory process was highly developed the effect of the kanamycin solution on the wound was lower. As for the use of the kanamycin films the regularity was the reverse: they had a higher therapeutic effect in pronounced inflammation and highly developed infection of the eye.
mesh_terms: D000818:Animals; D065306:Corneal Injuries; D004353:Drug Evaluation, Preclinical; D007612:Kanamycin / Q000008:administration & dosage*; D011817:Rabbits; D013997:Time Factors; D014946:Wound Infection / Q000188:drug therapy*; D014949:Wounds, Nonpenetrating / Q000188:drug therapy*
chemical_list: D007612:Kanamycin
vernacular_title: Vliianie razlichnykh lekarstvennykh form kanamitsina pri nepronikaiushchikh infitsirovannykh povrezhdeniiakh rogovitsy v éksperimente.