Atrioventricular conduction in dogs during anesthesia with isoflurane.
The effects of 1.25, 2.0, and 2.5 MAC isoflurane on atrioventricular conduction were studied by His-bindle electrocardiography during atrial pacing in ten dogs. No effect upon atrioventricular conduction as evidenced by changes in A--H interval (the time of conduction from low right atrium to His-bundle, representing primary AV nodal conduction) was found at these concentrations. Atrial pacing to 200 beats/min did not influence the A--H interval at the three anesthetic concentrations. The stability of cardiac rhythm observed clinically with isoflurane may be related to this lack of effect upon the AV node.
D000777:Anesthetics; D000818:Animals; D001283:Atrioventricular Node / Q000502:physiology*; D001784:Blood Gas Analysis; D001794:Blood Pressure / Q000187:drug effects; D002036:Bundle of His / Q000502:physiology; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D005260:Female; D006329:Heart Conduction System / Q000502:physiology*; D007530:Isoflurane; D008297:Male; D008738:Methyl Ethers
D000777:Anesthetics; D008738:Methyl Ethers; D007530:Isoflurane