Pentamidine in chemoimmunisation of cattle against Babesia bigemina infection.
A single dose of 0.5 to 1 mg/kg of Pentamidine led to clinical recovery of splenectomised calves infected with Babesia bigemina. On the other hand as much as 5 mg/kg administered during patency did not destroy the carrier state in intact calves. The fact that the sterilising dose was at least five times as great as that needed for clinical recovery makes Pentamidine a promising agent for chemoimmunisation against B. bigemina infection.
D000578:Amidines / Q000008:administration & dosage*; D000818:Animals; D001404:Babesiosis / Q000628:therapy / Q000662:veterinary*; D002353:Carrier State / Q000628:therapy; D002417:Cattle; D002418:Cattle Diseases / Q000628:therapy; D005260:Female; D007114:Immunization / Q000662:veterinary*; D008297:Male; D010419:Pentamidine / Q000008:administration & dosage*; D013156:Splenectomy
D000578:Amidines; D010419:Pentamidine