Ia antigens on indeterminate cells of the epidermis: immunoelectronmicroscopic studies of surface antigens.
An antiserum against human B-lymphoblastoid cell membrane alloantigens (Ia-like antigens) was used to study the presence of such antigens on dendritic cells in human epidermis. Only Langerhans cells and the majority (85%) of so-called indeterminate cells were positively stained, as shown by immuno-electron microscopy. Fifteen percent of the indeterminate cells were negative and were considered to be immature melanocytes. A relationship exists between the indeterminate cell and the Langerhans cell. A proposal is made concerning emigration of Langerhans cells in response to haptenic stimulation, and the immigration of indeterminate cells to restore the status quo.
D000954:Antigens, Surface / Q000032:analysis*; D004817:Epidermis / Q000276:immunology*; D006644:Histiocytes / Q000276:immunology; D006651:Histocytochemistry; D006801:Humans; D007120:Immunochemistry; D007519:Isoantigens / Q000032:analysis*; D007801:Langerhans Cells / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D008854:Microscopy, Electron
D000954:Antigens, Surface; D007519:Isoantigens