Plasma levels of progesterone, provera, oestradiol-17beta, and 13,14-dihydro-15-keto-prostaglandin F in cows treated with provera-impregnated intravaginal sponges.
Plasma concentrations of progesterone and Provera were measured daily in 3 cows during 21 days of treatment with Provera-impregnated intravaginal sponges. Plasma concentrations of oestradiol-17beta and 13,14-dihydro-15-keto-prostaglandin F (PGFM) were measured hourly from 5 h before until 62 h after sponge removal. The profile of progesterone concentrations indicated that luteolysis occurred at the expected time (Days 19 to 23 of the cycle), even though plasma Provera concentrations were 150-250 pg/ml. The occurrence of peaks of PGFM after sponge withdrawal suggests that PGF-2alpha release is stimulated by falling levels of progestagen.
D000818:Animals; D002417:Cattle; D003338:Corpus Luteum / Q000187:drug effects*; D004958:Estradiol / Q000097:blood*; D005260:Female; D003341:Luteolysis; D008525:Medroxyprogesterone / Q000031:analogs & derivatives* / Q000494:pharmacology; D011374:Progesterone / Q000097:blood*; D045167:Progesterone Congeners / Q000097:blood; D011460:Prostaglandins F / Q000097:blood*
D045167:Progesterone Congeners; D011460:Prostaglandins F; D011374:Progesterone; D004958:Estradiol; D008525:Medroxyprogesterone