[Analysis of urinary proteins from 50 patients with multiple myeloma by discelectrophoresis (author's transl)].
Urinary proteins from 50 patients with multiple myeloma (37 Ig G, 6 Ig A, 7 Bence Jones) were investigated by discelectrophoresis in polyacrylamidgels containing sodium dodecylsulfat. All samples were also characterized by immunelectrophoresis. Quantitatively and qualitatively normal proteinuria was found in 13 patients (26%). 22 patients (44%) had  monoclonal free light chains in the urine, kappachains were eliminated mainly in the monomeric form, lambdachains in all samples in the dimeric form. In 2 patients were found to exist light chains as monomers and dimers. 11 other patients (22%) had peaks of monoclonal Ig G or Ig A in the urine, always associated with the elimination of other nonmonoclonal proteins. Non-specific proteinuria was found in the remaining 4 patients. The clinical validity of the findings is discussed.
D004589:Electrophoresis, Disc; D005260:Female; D006801:Humans; D007122:Immunoelectrophoresis; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000652:urine; D010954:Plasmacytoma / Q000652:urine*; D011507:Proteinuria / Q000175:diagnosis*
D007070:Immunoglobulin A; D007074:Immunoglobulin G
Analyse der Urinproteine von 50 Patienten mit Plasmozytom durch die Diskelektrophorese.