Enhancement of radioresponse of a mouse mammary carcinoma to combined treatments with hyperthermia and radiosensitizer misonidazole.
The regrowth delay of a transplanted syngeneic mouse mammary carcinoma designated MT2 was used to estimate the effects of three-fold combination treatments: X-irradiation; hyperthermia and radiosensitizer; and misonidazole (Ro-07-0582). The experiment entailed five groups of experimental mice: untreated control; X-rays alone; X-rays plus hyperthermia (42--43 degrees); X-rays plus misonidazole; and X-rays plus hyperthermia plus misonidazole. X-Ray treatments consisted of 4000 rads administered locally to the tumors in two equal fractions at a 48-hr interval. Misonidazole (0.67 mg per g body weight) was injected i.p. 30 min before exposure to X-irradiation. Hyperthermia was administered 10 min prior to and for 17 min during irradiation. The regrowth delay factor of 3.9 was obtained by administering combined treatments of the three agents (X-rays plus hyperthermia plus misonidazole). The enhancing effect on a syngeneic mouse mammary adenocarcinoma by the modality of treatment herein described lends support to the usefulness of combining X-rays with other agents in the treatment of neoplasms.
D000230:Adenocarcinoma / Q000473:pathology / Q000628:therapy*; D000818:Animals; D006358:Hot Temperature / Q000627:therapeutic use*; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000473:pathology / Q000628:therapy*; D051379:Mice; D008920:Misonidazole / Q000008:administration & dosage*; D009593:Nitroimidazoles / Q000008:administration & dosage*; D011836:Radiation Tolerance; D012075:Remission, Spontaneous; D013997:Time Factors; D014965:X-Rays
D009593:Nitroimidazoles; D008920:Misonidazole