title: Cognitive and affective responses to lithium in patients with organic brain syndrome.
abstract: The authors describe a series of patients with organic brain syndrome who showed a dramatic clinical response to lithium carbonate therapy. None of the patients had been diagnosed as manic-depressive. Most had extensive psychiatric treatment experiences and had been given both affective and cognitive diagnoses. Six of the eight patients also qualified for the diagnosis of alcoholism. They had been treated with a wide variety of psychotherapeutic medications. Lithium was found to be rapidly and dramatically effective in patients with static lesions of the central nervous system who showed a combination of dementia and agitated depression.
mesh_terms: D000339:Affect / Q000187:drug effects*; D000425:Alcohol Amnestic Disorder / Q000188:drug therapy; D001714:Bipolar Disorder / Q000188:drug therapy; D001925:Brain Damage, Chronic / Q000150:complications; D002561:Cerebrovascular Disorders / Q000150:complications; D003071:Cognition / Q000187:drug effects*; D006801:Humans; D008094:Lithium / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000187:drug effects; D019965:Neurocognitive Disorders / Q000188:drug therapy*; D011595:Psychomotor Agitation / Q000188:drug therapy; D011604:Psychoses, Alcoholic / Q000188:drug therapy
chemical_list: D008094:Lithium