Effect of synthetic polynucleotides on the growth of transplantable tumours in BALB/c mice.
The effect of BALB/c mice pretreatment with tumour cells (a mammary adenocarcinoma, ADK-1t and an IgA secreting plasmocytoma, MOPC-315) adsorbed with poly I:C, poly I and poly C is examined. Only mice pretreated with cells of both tumours adsorbed with poly I:C and poly C proved to be extensively protected against challenge by homologous untreated tumour cells, whereas this was not so in the case of poly I. A possible explanation of this phenomenon is discussed.
D000818:Animals; D006084:Graft Rejection / Q000187:drug effects; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000473:pathology; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000276:immunology / Q000473:pathology*; D010954:Plasmacytoma / Q000473:pathology; D011066:Poly C / Q000494:pharmacology; D011069:Poly I / Q000494:pharmacology; D011070:Poly I-C / Q000494:pharmacology; D011131:Polyribonucleotides / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D011131:Polyribonucleotides; D011069:Poly I; D011066:Poly C; D011070:Poly I-C