[Effect of vitamins on permeability of cells, mitochondria and lysosomes under conditions of graviation overloading].
The gravitaiton overloading causes in experimental animals a decrease in stability of erythrocytes to NaCl hypotonic solutions and liver mitochondria to the effect of triton X=100. Under these conditions permeability of erythrocytes and leucocytes membranes as well as of the liver and brain mitochondria increases for [14C] nicotinate, [35S] lipoate, riboflavin and flavin mononucleotide, the total activity and the activity of the unprecipitable protinase of the liver cell lysosomas rise. Hydrocortisone, pyruvate, ATP, water- and fatty-soluble vitamins in the in vivo and in vitro experiments weaken the effect of overloading on the stability and permeability of the structures under study. Vitamin E applied separately and in combination with vitamin B, flavin mononucleotide and nicotinamide is more effective in this respect.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D001921:Brain / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D002463:Cell Membrane Permeability / Q000187:drug effects*; D004910:Erythrocyte Membrane / Q000378:metabolism; D007425:Intracellular Membranes / Q000187:drug effects / Q000378:metabolism*; D007962:Leukocytes / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008247:Lysosomes / Q000378:metabolism*; D051379:Mice; D008928:Mitochondria / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000378:metabolism; D010539:Permeability; D051381:Rats; D012965:Sodium Chloride / Q000378:metabolism; D014815:Vitamins / Q000494:pharmacology*
D014815:Vitamins; D012965:Sodium Chloride
Vliianie vitaminov na pronitsaemost' kletok, mitokhondriĭ i lizosom v usloviiakh gravitatsionnoĭ peregruzki.