Ethanol-inhibited platelet prostaglandin synthesis in vitro.
Inhibition of human platelet malonyldialdehyde (an indicator of platelet prostaglandin synthesis) in platelet-rich plasma, not found after 100 mg of ethanol per 100 ml in vitro, was dose-related at 200, 400 and 750 mg per 100 ml.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000328:Adult; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D003094:Collagen / Q000494:pharmacology; D003864:Depression, Chemical; D004837:Epinephrine / Q000494:pharmacology; D000431:Ethanol / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008315:Malondialdehyde / Q000097:blood; D010974:Platelet Aggregation / Q000187:drug effects; D011453:Prostaglandins / Q000096:biosynthesis* / Q000097:blood
D011453:Prostaglandins; D000431:Ethanol; D008315:Malondialdehyde; D000244:Adenosine Diphosphate; D003094:Collagen; D004837:Epinephrine