Structural studies on the murine Ia alloantigens. V. Evidence that the structural gene for the I-E/C beta polypeptide is encoded within the I-A subregion.
The E/C alpha- and beta-subunits of intra-I-region recombinants were analyzed for primary structural variation by comparative tryptic peptide mapping. The E/C alpha-polypeptides from B10.A, B10.A (3R) and B10.A (5R) showed complete coincident elution of peptides; the E/C beta-chains from B10.A and 3R (or 5R) were approximately 40% different. This suggests that the structural gene for the E/C beta-polypeptide is within the I-A subregion.
D000595:Amino Acid Sequence; D000818:Animals; D000954:Antigens, Surface / Q000235:genetics*; D005796:Genes; D007519:Isoantigens / Q000235:genetics*; D046911:Macromolecular Substances; D008285:Major Histocompatibility Complex; D051379:Mice; D010446:Peptide Fragments / Q000032:analysis
D000954:Antigens, Surface; D007519:Isoantigens; D046911:Macromolecular Substances; D010446:Peptide Fragments