title: Benign epithelioid cell nevi of the iris.
abstract: Two benign acquired melanocytic lesions of the iris stroma had distinctive clinical and pathologic features. One tumor was loculated and polypoid, suggesting ectopic glandular tissue, while the other was a flat tumor with a rich surface capillarity. Both lesions histologically were composed of mononucleated, binucleated, and multinucleated hypopigmented epithelioid and elongated "myoid" cells, widely separated in a finely fibrillar eosinophilic stroma. The ultrastructural features of one case included hyperconvoluted nuclei, conspicuous cytoplasmic filaments are rare, filamentary-striated (leptomeric) structures, scant organelles and inclusions except for numerous mitochondria and glycogen granules, small and infrequent melanosomes, and a fibrillary extracellular matrix focally organized into banded basement membrane material.
mesh_terms: D000328:Adult; D002386:Cataract / Q000150:complications; D005134:Eye Neoplasms / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007498:Iris / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D009508:Nevus, Pigmented / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure; D014603:Uveal Diseases / Q000473:pathology / Q000601:surgery