Metabolic activation and hepatotoxicity. Effect of cysteine, N-acetylcysteine, and methionine on glutathione biosynthesis and bromobenzene toxicity in isolated rat hepatocytes.
D000111:Acetylcysteine / Q000494:pharmacology*; D000818:Animals; D001711:Biotransformation; D001969:Bromobenzenes / Q000494:pharmacology*; D003545:Cysteine / Q000378:metabolism / Q000494:pharmacology*; D005978:Glutathione / Q000096:biosynthesis*; D066298:In Vitro Techniques; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008298:Maleates / Q000494:pharmacology; D008715:Methionine / Q000378:metabolism / Q000494:pharmacology*; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats
D001969:Bromobenzenes; D008298:Maleates; D008715:Methionine; D005978:Glutathione; D003545:Cysteine; D000111:Acetylcysteine; D010634:Phenobarbital