A radioreceptor assay for diazepam and its metabolites in serum.
A radioreceptor method is described for the estimation of serum concentrations of diazepam and its metabolites. The technique is simple, rapid and suitable for batch analysis. Ad advantage of the technique is that it gives a measure of the total pharmacological activity of the serum samples towards the benzodiazepine receptor and is thus directly applicable to benzodiazepines other than diazepam. The results obtained by the radioreceptor assay and by a GLC technique are correlated.
D000818:Animals; D001569:Benzodiazepines / Q000378:metabolism; D002417:Cattle; D002462:Cell Membrane / Q000378:metabolism; D002540:Cerebral Cortex; D002849:Chromatography, Gas; D003975:Diazepam / Q000097:blood*; D006801:Humans; D011869:Radioligand Assay; D011955:Receptors, Drug / Q000378:metabolism
D011955:Receptors, Drug; D001569:Benzodiazepines; D003975:Diazepam