title: Electron microscopic study of macrophages appearing in a stab wound of the brain of rats following intravenous injection of carbon particles.
abstract: Colloidal carbon was introduced intravenously into young rats to label circulating monocytes before the stabbing of the brain. The rats were sacrificed 1 to 14 days after the stab wound. In the rats sacrificed between 3 to 7 days after the stabbing, numerous phagocytic cells were present in the needle wound. Electron microscope study showed that some of these phagocytic cells carried intracytoplasmic carbon particles. These carbon-labelled cells showed features either of a monocyte, full-blown macrophages, or typical microglia. It is believed that they are all derived from circulating monocytes which have ingested carbon particles in circulation and thereafter invaded the stab wound.
mesh_terms: D000818:Animals; D002244:Carbon; D002540:Cerebral Cortex / Q000293:injuries* / Q000473:pathology; D003337:Corpus Callosum / Q000293:injuries* / Q000473:pathology; D007275:Injections, Intravenous; D008264:Macrophages / Q000648:ultrastructure*; D008854:Microscopy, Electron; D009000:Monocytes / Q000648:ultrastructure; D051381:Rats; D014951:Wounds, Stab / Q000473:pathology*
chemical_list: D002244:Carbon