title: Non-parallel secretion of pancreatic enzymes. Effect of parenteral amino acid administration and intestinal reinfusion of bilio-pancreatic juice.
abstract: Chronic drainage of pancreatic juice in rats results in a non-parallel secretion of digestive enzymes. The concentration of trypsinogen, chymotrypsinogen, procarboxypeptidase B and lipase increases continuously whereas that of amylase drops. An amino acid mixture given intravenously does not affect this dissociation. Reinfusion of bilio-pancreatic juice into the duodenum on the contrary influences the relative enzyme release: the increase in concentration of the three proteolytic enzymes and of lipase is less pronounced over the 72-hour study period; amylase concentration remains unaffected. In the absence of an intravenous amino acid feeding the pancreatic protein output is more than halved and a negative nitrogen balance is observed. Reinfusion of bilio-pancreatic juice does not alter the total protein output. This report confirms the persistance of a dissociation in the rate of enzyme release in rats with chronic pancreatic fistula despite sufficient protein administration and intestinal reintroduction of bilio-pancreatic juice.
mesh_terms: D000596:Amino Acids / Q000008:administration & dosage / Q000494:pharmacology*; D000681:Amylases / Q000378:metabolism*; D000818:Animals; D002919:Chymotrypsinogen / Q000378:metabolism*; D004386:Duodenum; D010450:Endopeptidases / Q000378:metabolism*; D007263:Infusions, Parenteral; D007583:Jejunum; D008049:Lipase / Q000378:metabolism*; D008297:Male; D010179:Pancreas / Q000201:enzymology / Q000378:metabolism*; D010189:Pancreatic Juice / Q000201:enzymology*; D051381:Rats; D012636:Secretory Rate; D014362:Trypsinogen / Q000378:metabolism*
chemical_list: D000596:Amino Acids; D014362:Trypsinogen; D002919:Chymotrypsinogen; D008049:Lipase; D000681:Amylases; D010450:Endopeptidases