Annulate lamellae in human tumor cells.
Annulate lamellae have been found in a primitive neuroectodermal tumor, a metastatic cerebellar tumor, a testicular seminoma, a retinoblastoma and three melanomas. These annulate lamellae are arranged in stacked parallel arrays in the cytoplasm of tumor cells. The number of annulate lamellae observed to comprise a single stack varies from 2--4 in the seminoma tumor to 5--18 in the cerebellar tumor. Although the functional significance of annulate lamallae is still unknown, in many instances they have been found to be continuous with rough-surfaced cisternae of the endoplasmic reticulum and ribosomes have been demonstrated on the surface of annulate lamellae. This may suggest that annulate lamellae participate in protein synthesis.
D002528:Cerebellar Neoplasms / Q000648:ultrastructure; D004407:Dysgerminoma / Q000648:ultrastructure; D005134:Eye Neoplasms / Q000648:ultrastructure; D006801:Humans; D008297:Male; D008545:Melanoma / Q000648:ultrastructure; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000648:ultrastructure*; D009940:Organoids / Q000648:ultrastructure*; D012175:Retinoblastoma / Q000648:ultrastructure; D012878:Skin Neoplasms / Q000648:ultrastructure; D013736:Testicular Neoplasms / Q000648:ultrastructure