Adrenal corticosteroids cause gastrin cell hyperplasia.
Chronic exogenous high dose adrenal cortical steroid administration to dogs resulted in a 137% increase in G-cell mass with an associated enhancement of peak serum gastrin levels. Adrenalectomy caused a halving of G-cell numbers without significant changes in serum gastrin levels. Adrenal cortical steroids appear to have an important trophic role for the G-cell.
D000305:Adrenal Cortex Hormones / Q000494:pharmacology*; D000315:Adrenalectomy; D000818:Animals; D002452:Cell Count; D004285:Dogs; D004435:Eating; D005215:Fasting; D005753:Gastric Mucosa / Q000166:cytology* / Q000378:metabolism; D005755:Gastrins / Q000097:blood / Q000378:metabolism*; D011706:Pyloric Antrum / Q000166:cytology* / Q000378:metabolism
D000305:Adrenal Cortex Hormones; D005755:Gastrins