Modification by dipyrone (noramidopyrine methanesulphonate) of stone-induced ureteric hyperperistalsis in the dog.
Implantation of a stone in the ureter of the dog by ureterotomy results in focal hyperperistalsis which is accentuated by administration of norepinephrine, and reduced by administration of phenoxybenzamine or isoproterenol. Administration of dipyrone reduces the hyperperistalsis, but this action does not appear to be that of either a beta-agonist of an alpha-antagonist.
D000632:Aminopyrine / Q000031:analogs & derivatives*; D000818:Animals; D004177:Dipyrone / Q000627:therapeutic use*; D004285:Dogs; D004837:Epinephrine / Q000494:pharmacology; D007545:Isoproterenol / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D010276:Parasympatholytics / Q000627:therapeutic use*; D010643:Phenoxybenzamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D014513:Ureter / Q000187:drug effects*; D014514:Ureteral Calculi / Q000150:complications*
D010276:Parasympatholytics; D000632:Aminopyrine; D010643:Phenoxybenzamine; D004177:Dipyrone; D011433:Propranolol; D007545:Isoproterenol; D009638:Norepinephrine; D004837:Epinephrine