Neuropharmacological actions of labetalol.
Labetalol, an alpha- and beta- adrenoceptor antagonist was investigated for its central nervous system effects in rats and mice. A marked reduction in the spontaneous motor activity with no concomittant muscle weakness was produced. The drug caused closure of eyelids in rats. Labetalol caused hypothermia and prolonged the pentobarbitone-induced hyposis. In animals trained for conditioned avoidance response the drug blocked the SCR in all the animals and CAR in a few number of animals. The drug did  not protect the animals against electroshock convulsions. From the results it appears that labetalol is a central nervous system depressant.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects*; D003216:Conditioning, Operant / Q000187:drug effects; D003864:Depression, Chemical; D004357:Drug Synergism; D004983:Ethanolamines / Q000494:pharmacology*; D005260:Female; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D007741:Labetalol / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010424:Pentobarbital / Q000494:pharmacology; D051381:Rats; D012640:Seizures / Q000517:prevention & control
D004983:Ethanolamines; D006993:Hypnotics and Sedatives; D010424:Pentobarbital; D007741:Labetalol