Serum phenytoin, phenobarbital, carbamazepine, albumin; and plasma estradiol, progesterone concentrations during the menstrual cycle in women with epilepsy.
Six menstrual cycles and three 1-month periods were studied in seven patients with epilepsy. The patients all had had anti-epileptic treatment for a long time. In each case, the dosages had been costant for at least 1 month prior to the start of the investigation. Blood samples were taken every second day. Phenytoin, phenobarbital, carbamazepine, estradiol and pregesterone were analyzed. The serum levels of the anti-epileptic drugs were correlated to the plasma hormone concentrations. No correlations were obtained between the plasma hormone concentrations and the serum levels of the anti-epileptic drugs. There is, therefore, no evidence that the relationship between the seizure frequency and plasma hormone concentrations, shown in a previous study (Bäckström 1976)) was related to a change in serum levels of the anti-epileptic drugs.
D000328:Adult; D002220:Carbamazepine / Q000008:administration & dosage / Q000097:blood* / Q000627:therapeutic use; D004827:Epilepsy / Q000097:blood* / Q000188:drug therapy; D004958:Estradiol / Q000097:blood*; D005260:Female; D006801:Humans; D008598:Menstruation; D010634:Phenobarbital / Q000008:administration & dosage / Q000097:blood* / Q000627:therapeutic use; D010672:Phenytoin / Q000008:administration & dosage / Q000097:blood* / Q000627:therapeutic use; D011374:Progesterone / Q000097:blood*; D012709:Serum Albumin / Q000032:analysis
D012709:Serum Albumin; D002220:Carbamazepine; D011374:Progesterone; D004958:Estradiol; D010672:Phenytoin; D010634:Phenobarbital