Proline-rich polypeptide from ovine colostrum: its effect on skin permeability and on the immune response.
The effect of a proline-rich polypeptide from ovine colostrum on the humoral immune response in mice against sheep red blood cells (SRBC) was studied. It was shown that the polypeptide had a regulatory activity stimulating or suppressing the immune response. The proline-rich polypeptide also increased the permeability of skin vessels in guinea-pigs. Studies on the mechanism of the effect of the proline-rich polypeptide suggest that prostaglandins are involved in the activity of the polypeptide.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D002199:Capillary Permeability / Q000187:drug effects*; D002227:Carbazoles / Q000494:pharmacology; D003126:Colostrum / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006168:Guinea Pigs; D008297:Male; D051379:Mice; D010455:Peptides / Q000494:pharmacology*; D011392:Proline; D011448:Prostaglandin Antagonists / Q000494:pharmacology; D012756:Sheep; D012867:Skin / Q000098:blood supply; D013997:Time Factors
D002227:Carbazoles; D010455:Peptides; D011448:Prostaglandin Antagonists; D011392:Proline