[Effect of droperidol, aminazine and diazepam on the analgesic activity of leucine-enkephalin].
In experiments on rats it was shown that the neuroleptics droperidol (0.6 mg/kg) and aminazin (10 mg/kg) can potentiate the analgetic action of the endogenous morphine-like pentapeptide leucin-enkephalin administered into the brain ventricles at a dose of 50 micrograms. A statistically significant increase in the analgetic activity lf leucin-enkephalin given at a dose of 100 micrograms was induced only by droperidol. The tranquilizer diazepam (5 mg/kg) had no effect on the action lf leucin-enkephalin. Naloxon (2 mg/kg) removed the analgetic effect of leuchin-enkephalin administered both alone and after a preliminary injection od droperidol or aminazin.
D000818:Animals; D002746:Chlorpromazine / Q000008:administration & dosage*; D003975:Diazepam / Q000008:administration & dosage*; D004329:Droperidol / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D004723:Endorphins / Q000008:administration & dosage*; D004745:Enkephalins / Q000008:administration & dosage* / Q000037:antagonists & inhibitors; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D009270:Naloxone / Q000008:administration & dosage; D010146:Pain / Q000188:drug therapy*; D051381:Rats
D004723:Endorphins; D004745:Enkephalins; D009270:Naloxone; D004329:Droperidol; D003975:Diazepam; D002746:Chlorpromazine
Vliianie droperidol, aminazina i diazepama na anal'geticheskuiu aktivnost' leĭtsin-énkefalina.