title: IgA deficiency in juvenile chronic polyarthritis.
abstract: Immunoglobulins measured sequentially in 582 juvenile chronic polyarthritis patients revealed 12 with persistently absent IgA and 15 consistently below 20 mg/dl. There was an increased presentation with pauciarticular onset but systemic disease was the same as in the whole group. Follow-up showed that 9 of the 12 without IgA developed polyarthritis as have 11 of the 15 with low IgA; in contrast to previous studies, the disease has been severe in at least half of the patients.
mesh_terms: D000293:Adolescent; D001171:Arthritis, Juvenile / Q000150:complications* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D004406:Dysgammaglobulinemia / Q000150:complications* / Q000276:immunology; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007223:Infant; D008297:Male
chemical_list: D007070:Immunoglobulin A