Spectrofluorometric assay of chlorpromazine, half-life and pharmacokinetics of chlorpromazine in goats of different ages.
The pharmacokinetics studies in 48 experiments on the animals of different ages showed that the half-life of CPZ in kids (new born, 1 week and 3 weeks old) and goats (3 months old and adult animals) ranged from 1.47 to 1.86 hour while distribution half-life was only 0.11 to 0.17 hour. Volume of distribution of CPZ in kids and goats was much higher than 1 which indicated that the drug was extensively localized in the tissues. The elimination of CPZ was more rapid in the adult goats than in the kids. The half-life of CPZ was short and elimination was rapid in the goats as compared to the literature values for man, rat and dog. The differences are attributed primarily to the more rapid metabolism of CPZ in the goats than in the kids or man, rat and dog.
D000367:Age Factors; D000818:Animals; D002746:Chlorpromazine / Q000097:blood / Q000378:metabolism*; D004285:Dogs; D006041:Goats / Q000378:metabolism*; D006207:Half-Life; D006801:Humans; D007202:Indicators and Reagents; D051381:Rats; D013045:Species Specificity; D013050:Spectrometry, Fluorescence; D013454:Sulfoxides / Q000378:metabolism
D007202:Indicators and Reagents; D013454:Sulfoxides; D002746:Chlorpromazine