The relationship of cellular respiration inhibition activity of 7-substituted 4-hydroxyquinoline-3-carboxylic acids with van der Waals volume.
The cellular respiratory inhibition activity of 7-substituted 4-hydroxyquinoline-3-carboxylic acids recently designed by Shah and Coats is found by regression analysis to be significantly correlated with van der Waals volume (V(w)). A parabolic correlation is obtained in case of ascites cell inhibition and a linear correlation in case of malate dehydrogenase inhibition. The correlation of both types of inhibition with a single parameter, V(w), makes the process of substituent selection in designing more potent inhibitors of whole respiratory cell much simpler.
D001202:Ascitic Fluid / Q000166:cytology; D006912:Hydroxyquinolines / Q000494:pharmacology*; D008291:Malate Dehydrogenase / Q000037:antagonists & inhibitors; D008954:Models, Biological; D010101:Oxygen Consumption / Q000187:drug effects*; D011789:Quantum Theory; D013329:Structure-Activity Relationship
D006912:Hydroxyquinolines; D008291:Malate Dehydrogenase