title: [Mastocyte osteoporosis].
abstract: We present five cases of severe osteoporosis accompanied by a skin and/or bone mastocytosis. The rarity of mastocytosis demonstrates that these cases are not the result of simple coincidence, especially since none of them involves other general of phospho-calcium anomalies that could explain the demineralization. The latter is accompanied by a high level of histaminemia or histaminuria, a non-specific anomaly. Mastocyte osteoporosis involves a great many unknown factors on the physiopathological level, but in practice it is necessary to look for a mastocytosis when confronted with a severe osteoporosis that appears to be primary. Cytostatic treatment (chlorambucil, cyclophosphamide) seems capable of improving the evolution of the bone disease.
mesh_terms: D000328:Adult; D000368:Aged; D001842:Bone and Bones / Q000503:physiopathology; D002118:Calcium / Q000378:metabolism; D003404:Creatinine / Q000378:metabolism; D005260:Female; D006632:Histamine / Q000378:metabolism; D006801:Humans; D008297:Male; D008407:Mast Cells / Q000502:physiology*; D008875:Middle Aged; D010024:Osteoporosis / Q000175:diagnosis / Q000503:physiopathology*; D010710:Phosphates / Q000378:metabolism; D012867:Skin / Q000503:physiopathology
chemical_list: D010710:Phosphates; D006632:Histamine; D003404:Creatinine; D002118:Calcium
vernacular_title: L'ostéoporose mastocytaire.