title: Distribution of PNMT and epinephrine in the medulla oblongata of normotensive and spontaneous hypertensive rats.
abstract: The distribution of the Epinephrine forming enzyme (PNMT) activity and Epinephrine (E) levels was investigated in the medulla oblongata of spontaneous hypertensive rats (SH-rats) and in two normotensive strains, namely Wistar Kyoto rats (WK-rats) and Wistar rats. The PNMT activity increases progressively from the caudal to rostral parts in the C1 and C2 regions of the medulla oblongata. The enzyme activity and the E levels are in all parts of the C1 and C2 regions higher in Wistar rats than in WK-rats. The PNMT activity in all parts of the C2 region (with the exception of the caudal region), and in the middle part of the C1 region is higher in SH-rats than in WK-rats. The E levels in the SH-rats are higher than in WK-rats in the mediocaudal parts of the C2 and C1 regions.
mesh_terms: D000818:Animals; D001794:Blood Pressure; D004837:Epinephrine / Q000032:analysis / Q000378:metabolism*; D006973:Hypertension / Q000378:metabolism*; D008297:Male; D008526:Medulla Oblongata / Q000378:metabolism*; D010625:Phenylethanolamine N-Methyltransferase / Q000032:analysis / Q000378:metabolism*; D051381:Rats
chemical_list: D010625:Phenylethanolamine N-Methyltransferase; D004837:Epinephrine