Schistosoma mansoni: activity responses in vitro to praziquantel.
The effects of praziquantel, a novel antischistosomal compound, on the activity of adult Schistosoma mansoni (Liverpool strain) in vitro were investigated. Worm activity was modified at all concentrations of praziquantel. High concentrations (above 0.5 microgram/ml) produced rapid paralysis, whilst low concentrations of praziquantel stimulated worm activity. It is concluded that such activity modification could lead to worm displacement in vivo.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D007546:Isoquinolines / Q000494:pharmacology*; D011719:Pyrazines / Q000494:pharmacology*; D012550:Schistosoma mansoni / Q000187:drug effects*; D012556:Schistosomicides / Q000494:pharmacology*; D012996:Solutions; D013997:Time Factors
D007546:Isoquinolines; D011719:Pyrazines; D012556:Schistosomicides; D012996:Solutions