CSF copper in schizophrenia.
The authors measured copper levels in the cerebrospinal fluid of 8 schizophrenic subjects and 6 controls. The schizophrenic subjects had significantly lower CSF copper values than the controls, which is consistent with the hypothesis that there is reduced central activity of copper-dependent enzymes in schizophrenia. These enzymes, tyrosine hydroxylase and dopamine-beta-hydroxylase, are involved in the synthesis and catabolism of dopamine.
D003300:Copper / Q000134:cerebrospinal fluid*; D004298:Dopamine / Q000378:metabolism; D006801:Humans; D012559:Schizophrenia / Q000134:cerebrospinal fluid*
D003300:Copper; D004298:Dopamine