Cytogenetic investigation of occupational exposure to epichlorohydrin.
Cytogenetic evaluation of peripheral lymphocytes from 93 workers currently exposed to epichlorohydrin has revealed an increase in aberration rates as compared to that of a 75-person group seen for preemployment examination. Statistically significant differences were found in the distribution of individuals with chromatid breaks, chromosome breaks, severely damaged cells, and total abnormal cells. These results confirm the observations of Kucerova et al. in a similar occupational group.
D000328:Adult; D002728:Chlorohydrins / Q000009:adverse effects*; D002842:Chromatids / Q000187:drug effects; D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D004811:Epichlorohydrin / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure; D008297:Male; D008452:Maximum Allowable Concentration; D008875:Middle Aged; D009153:Mutagens; D009784:Occupational Diseases / Q000139:chemically induced*
D002728:Chlorohydrins; D009153:Mutagens; D004811:Epichlorohydrin