Nephrotic syndrome in procainamide induced lupus nephritis.
We report a case of the nephrotic syndrome occurring in a patient with procainamide induced LE. It was associated with bilateral pleural effusions, pericarditis, fever, positive LE cell preparation and a high titer of antinuclear antibodies. No anti-DNA antibodies were found. Renal biopsy showed mesangial proliferation with few IgM and C3 deposits and interstitial infiltrates; electron microscopy revealed subendothelial deposits. Clinical improvement occured after steroid therapy and there was no recurrence 24 months after withdrawal of prednisone.
D000368:Aged; D005260:Female; D006801:Humans; D007668:Kidney / Q000473:pathology; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D009393:Nephritis / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D009404:Nephrotic Syndrome / Q000139:chemically induced*; D011241:Prednisone / Q000627:therapeutic use; D011342:Procainamide / Q000009:adverse effects*; D013577:Syndrome
D011342:Procainamide; D011241:Prednisone