Evidence for two homologous, but nonidentical, Ia molecules determined by the I-EC subregion.
Sequential immunoprecipitation, two-dimensional gel electrophoresis and peptide mapping analyses of B10A(3R), 35S-methionine-labeled, I-EC subregion products were performed. Evidence is presented here for the presence of two structurally homologous, but nonidentical, gene products of the I-EC subregion. These two Ia molecules are independently immunoprecipitable, identical in molecular size and charge, but differ by approximately equal to 20% in their peptides obtained by partial digestion with Staphylococcus aureus protease V8.
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D004587:Electrophoresis, Agar Gel; D006183:H-2 Antigens / Q000235:genetics*; D008285:Major Histocompatibility Complex; D051379:Mice; D008970:Molecular Weight
D000596:Amino Acids; D006183:H-2 Antigens