Occupational effect of phosfolan insecticide on spraymen during field exposure.
Phosfolan (Cyolane), 2-(diethoxy phosphinylimino)-1,3-dithiolane is one of the widely used insecticides in Egypt specially to protect cotton plants. The hazard of exposure of the spray workers team in the field was estimated in terms of the amount of Phosfolan insecticide retained on workmen body pads during field spraying. The health effect of such exposure was determined through recording of the AChE inhibition in the red blood cells at different intervals after exposure. The calculated percentage of the toxic dose received per every spraying day for each worker varied with the type of job in the range of 0.008 to 0.03 percent. The body of the mixer received the maximum exposure with 10 to 12 fold that of the assistants. The highly exposed group of workers suffered from 31 to 44 percent RBC's AChE inhibition. About half of the inhibited enzyme activity recovered after 48 hours. Then it took more than 3-4 weeks to reach complete recovery. Thus the RBC's AChE activity can be recommended as a criterion for the level of exposure to organophosphorous insecticides.
D000110:Acetylcholinesterase / Q000097:blood; D000382:Agricultural Workers' Diseases / Q000139:chemically induced* / Q000378:metabolism; D004912:Erythrocytes / Q000201:enzymology; D006801:Humans; D007306:Insecticides / Q000378:metabolism / Q000506:poisoning*; D009946:Organothiophosphorus Compounds; D012869:Skin Absorption; D013997:Time Factors
D007306:Insecticides; D009946:Organothiophosphorus Compounds; C002301:phosfolan; D000110:Acetylcholinesterase