Sertoli cells of adult rats in vitro. II. Effect of different steroid precursors on estradiol 17 beta-synthesis.
The estradiol 17 beta-synthesis by delta 4 pathway has been studied in homogenous cultures of Sertoli cells isolated from adult rat testes. The data reported clearly demonstrate that progesterone, androstenedione, testosterone and estrone induce an increase of the estradiol 17 beta-production.
D000735:Androstenedione / Q000494:pharmacology; D000818:Animals; D002478:Cells, Cultured; D004958:Estradiol / Q000096:biosynthesis*; D004970:Estrone / Q000494:pharmacology; D008297:Male; D011374:Progesterone / Q000494:pharmacology; D051381:Rats; D012708:Sertoli Cells / Q000187:drug effects / Q000378:metabolism*; D013739:Testosterone / Q000494:pharmacology
D004970:Estrone; D013739:Testosterone; D000735:Androstenedione; D011374:Progesterone; D004958:Estradiol