Synthesis of the sultam analog of 11-deoxy PGE2.
As an extension of our work on the series of N-alkylmethanesulfonamidoheptanoic acids, we have prepared the cyclic-sulfonamide (sultam) analog of 11-deoxy PGE2. Although numerous publications have described the introduction of heteroatoms into the 5-membered ring of the prostaglandins, the cyclic-sulfonamides have remained a heretofore unexplored class. The synthetic scheme for the preparation of this unique PG analog is presented in this paper.
D055598:Chemical Phenomena; D002621:Chemistry; D011458:Prostaglandins E / Q000138:chemical synthesis*; D013449:Sulfonamides / Q000138:chemical synthesis*
D011458:Prostaglandins E; D013449:Sulfonamides