title: Measurement of regional cerebral blood flow by intravenous injection of Xe133.
abstract: Clearance of Xenon 133 following intravenous injection has been used to perform atraumatic measurements of regional cerebral blood flow (rCBF). rCBF was computed by a two-compartmental analysis of the clearance curves associated with a correction for Xenon recirculation based on the end-tidal tracer concentration. Direct comparison was made between the results of this method and those obtained from the reference intracarotid method. A systematic analysis has shown that the results of the non-invasive method depend on the part of the clearance curves chosen for computation of rCBF. The best concordance with the intra-carotid method was found when the analysed part of the curve was situated between 3 and 11 min. after the beginning of the injection. Under these conditions, the differences between the results from the two methods did not exceed 10% of the flow values even for low flows. Such precision makes the atraumatic measurements of rCBF by intravenous injection of Xenon valuable for clinical applications.
mesh_terms: D002560:Cerebrovascular Circulation; D003201:Computers; D006801:Humans; D007275:Injections, Intravenous; D008433:Mathematics; D008954:Models, Biological; D014980:Xenon Radioisotopes
chemical_list: D014980:Xenon Radioisotopes