Effects of isoproterenol and dopamine on the myocardial hexose monophosphate shunt.
Long-term exposure of rats to isoproterenol and dopamine resulted in an increase of glucose-6-phosphate dehydrogenase activity and a greater availability of 5-phosphoribosyl-l-pyrophosphate in the myocardium. These results are interpreted to indicate an enhanced flow through the hexose monophosphate shunt.
D000227:Adenine Nucleotides / Q000378:metabolism; D000818:Animals; D004298:Dopamine / Q000494:pharmacology*; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D006321:Heart / Q000187:drug effects; D006600:Hexosephosphates / Q000378:metabolism*; D007545:Isoproterenol / Q000494:pharmacology*; D009206:Myocardium / Q000378:metabolism*; D010754:Phosphoribosyl Pyrophosphate / Q000378:metabolism; D051381:Rats
D000227:Adenine Nucleotides; D006600:Hexosephosphates; D010754:Phosphoribosyl Pyrophosphate; D005954:Glucosephosphate Dehydrogenase; D007545:Isoproterenol; D004298:Dopamine