title: Nephrotic syndrome associated with methimazole therapy.
abstract: Thionamide drugs are widely used in the management of hyperthyroidism and are infrequently associated with adverse reactions. We report the development of the nephrotic syndrome during methimazole (Tapazole) therapy in a young man with Graves' disease. His proteinuria remitted promptly with discontinuance of the drug, and renal histologic features bore a striking resemblance to the toxic nephrosis induced in animals by the aminonucleoside of puromycin. In view of the histologic similarities, we propose that methimazole acted as a direct glomerular toxin, inducing the nephrotic syndrome in this patient.
mesh_terms: D000328:Adult; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy; D008297:Male; D008713:Methimazole / Q000009:adverse effects* / Q000627:therapeutic use; D009404:Nephrotic Syndrome / Q000139:chemically induced* / Q000473:pathology
chemical_list: D008713:Methimazole