[Cancerostatic effect of some fluorenone azomethines tested against leukemia L 1210 (author's transl)].
Eight of fifteen Fluorenone-Azomethines without alkylating function have been found effective against the leukemia L 1210. Little modifications concerning the structure of the compounds caused loss of effectiveness. It seems remarkably that one corresponding derivative with a nitrogen mustard group (4) was ineffective. Correlations between chemical structure and biological effect have not yet been found.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D005260:Female; D005449:Fluorenes / Q000627:therapeutic use*; D007939:Leukemia L1210 / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008811:Mice, Inbred DBA; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D005449:Fluorenes
Ergebnisse der Prüfung einiger Azomethine des Fluorenons auf kanzerostatische Wirkung an der Leukämie L 1210.