[State of the erythrocyte surface (echinocytosis) in experimental carcinogenesis].
Characteristic red cell deformation, echinocytosis peculiar to mammary tumour susceptible C3H mice, were revealed by a comparative study of erythrocytes in animals with a different natural resistance to spontaneous carcinogenesis. 58.6% of spiny red cells was found at the early latent period (at the age of 3-4 months) and reached 91.1% at the late latent period (at the age of 11-12 months). In the blood of intact C57BL/6 mice resistant to mammary carcinogenesis, at the same ages the echinocyte count ranged from 16.0 to 18.7%. The tumour growth (spontaneous tumour in C3H mice and transplantable Ehrlich adenocarcinoma in C57BL/6 mice was accompanied by an increase in the echynocyte count and in the expression of echinocytosis (up to 96.6 and 65.3%, respectively). Possible pathogenetic mechanisms of echinocytosis in carcinogenesis are discussed.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000097:blood* / Q000473:pathology; D004913:Erythrocytes, Abnormal / Q000473:pathology*; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000097:blood* / Q000473:pathology; D051379:Mice; D009367:Neoplasm Staging
Sostoianie poverkhnosti éritrotsitov (ékhinotsitoz) pri éksperimental'nom kantserogeneze.