Quantitative ultrastructural features of maturing mononuclear phagocytes in rat peritoneal fluids.
Ultrastructural features of the in vivo transformation of macrophage congeners in resident and adjuvant-induced peritoneal populations are evaluated by sterological methods. Maturation involves an increase in cell size by the differential hypertrophy of subcellular compartments, notably remaining cytoplasm, nucleus and lysosome-like granules. Larger cells have more and larger granules, more mitochondria and a greater plasmalemmal surface. In contrast, adjuvant activation tends to produce fewer granules and a nett loss of surface membrane.
D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology*; D002462:Cell Membrane / Q000648:ultrastructure; D003593:Cytoplasm / Q000648:ultrastructure; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D006056:Golgi Apparatus / Q000648:ultrastructure; D008264:Macrophages / Q000502:physiology / Q000648:ultrastructure*; D009940:Organoids / Q000648:ultrastructure; D051381:Rats