title: Alteration of oxygen tension and oxyhemoglobin saturation. A hazard of sodium bicarbonate administration.
abstract: The administration of sodium bicarbonate solution, which has been advocated for the treatment of metabolic acidosis, may have detrimental side effects. We evaluated oxyhemoglobin saturation and oxygen tensions in eight anesthetized swine before and after freshwater near-drowning and after a rapid intravenous infusion of 7.5% sodium bicarbonate solution (8 mEq/kg). After freshwater aspiration, arterial and venous oxygen tensions and oxyhemoglobin saturation decreased. Administration of sodium bicarbonate resulted in decreased venous and increased arterial, oxygen tensions. Arterial, but not venous, oxyhemoglobin saturation increased. These findings suggest that sodium bicarbonate caused a distinct leftward shift in the oxyhemoglobin dissociation curve, which could impair tissue oxygenation. Therefore, to avoid detrimental effects, sodium bicarbonate should be administered slowly and in a dose sufficient just to correct metabolic acidosis.
mesh_terms: D000138:Acidosis / Q000188:drug therapy; D000142:Acidosis, Respiratory / Q000188:drug therapy; D000818:Animals; D001639:Bicarbonates / Q000009:adverse effects* / Q000627:therapeutic use; D002245:Carbon Dioxide / Q000097:blood; D002302:Cardiac Output / Q000187:drug effects; D004912:Erythrocytes / Q000378:metabolism; D009994:Osmolar Concentration; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption; D010108:Oxyhemoglobins / Q000032:analysis*; D012964:Sodium / Q000009:adverse effects* / Q000627:therapeutic use; D013552:Swine
chemical_list: D001639:Bicarbonates; D010108:Oxyhemoglobins; D002245:Carbon Dioxide; D012964:Sodium; D010100:Oxygen