2',3'-Bis(2-chloroethyl)aminophosphoryl-3'-amino-3'-deoxyadenosine: a cyclic nucleotide with antitumor activity.
The synthesis of the title compound from 3'-amino-3'-deoxyadenosine in 40% yield is reported. 3'-Amino-3'-deoxyadenosine was made by an improved synthesis in 12 steps from inexpensive D-xylose in 15% overall yield. Both isomers of the title compound, separated by column chromatography, possess confirmed activity against KB tumor cell cultures.
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D003838:Deoxyadenine Nucleotides / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D066298:In Vitro Techniques; D007939:Leukemia L1210 / Q000188:drug therapy; D008722:Methods; D051379:Mice; D009712:Nucleotides, Cyclic / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D010752:Phosphoramide Mustards / Q000138:chemical synthesis* / Q000627:therapeutic use
D003838:Deoxyadenine Nucleotides; D009712:Nucleotides, Cyclic; D010752:Phosphoramide Mustards; C020230:2',3'-bis(2-chloroethyl)aminophosphoryl-3'-amino-3'-deoxyadenosine