Structural studies on the murine Ia alloantigens. IV. NH2-terminal sequence analysis of allelic products of the I-A and I-E/C subregions.
Murine Ia alloantigens encoded by the I-A and I-E/C subregions were isolated from radiolabeled splenic lysates and examined by NH2-terminal sequence analysis. Haplotype-associated sequence variation was detected in the beta, but not alpha, subunits of both the A and E/C alloantigens. The A beta-polypeptides from k and b haplotypes show four differences in the 12 positions compared, whereas the E/C beta-polypeptides from k and r haplotypes show two differences in the 13 positions compared. No sequence variation was detected between the Ak and Ab  alpha-chains (six positions compared) or between the E/Ck and E/Cr alpha-chains (11 positions compared). Homology relationships between these murine Ia alloantigens and the human Ia (DR) alloantigens are also presented.
D000483:Alleles; D000595:Amino Acid Sequence; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D004591:Electrophoresis, Polyacrylamide Gel; D007106:Immune Sera; D007519:Isoantigens / Q000235:genetics*; D008285:Major Histocompatibility Complex; D051379:Mice; D008805:Mice, Inbred A; D008810:Mice, Inbred C57BL; D014176:Protein Biosynthesis
D007106:Immune Sera; D007519:Isoantigens