title: Effect of cimetidine on chronic gastric ulcers produced experimentally in rats.
abstract: The authors have studied the effects of cimetidine on the healing of chronic gastric ulcers induced in rats. Gastric ulcers were produced by topical application of 60% acetic acid to the serosal surface of the lesser curvature of the stomach. Oral administration of cimetidine, 150 mg/kg daily, in two divided doses for a maximum of 14 days failed to produce any significant acceleration of healing.
mesh_terms: D000085:Acetates; D000284:Administration, Oral; D000818:Animals; D002908:Chronic Disease; D002927:Cimetidine / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D004848:Epithelium / Q000502:physiology; D006146:Guanidines / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D012038:Regeneration / Q000187:drug effects; D013270:Stomach / Q000502:physiology; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000085:Acetates; D006146:Guanidines; D002927:Cimetidine