Intestinal dilatation associated with phenothiazine therapy: a case report and literature review.
The authors describe a fatal episode of intestinal dilatation associated with chlorpromazine therapy. A total of 26 similar cases associated with phenothiazine or tricyclic antidepressant therapy, including 9 fatalities, has been reported in the literature. The authors cite experimental evidence supporting this association. They emphasize the difficulty of recognizing this syndrome in the psychotic patient; careful evaluation is indicated in the constipated patient who exhibits vomiting, abdominal pain, distension, or tenderness.
D000328:Adult; D001590:Benztropine / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000188:drug therapy; D002746:Chlorpromazine / Q000009:adverse effects* / Q000627:therapeutic use; D004108:Dilatation, Pathologic / Q000139:chemically induced / Q000473:pathology; D004359:Drug Therapy, Combination; D005769:Gastrointestinal Motility / Q000187:drug effects; D006801:Humans; D007410:Intestinal Diseases / Q000139:chemically induced* / Q000473:pathology; D007422:Intestines / Q000473:pathology; D008094:Lithium / Q000627:therapeutic use; D008297:Male
D001590:Benztropine; D008094:Lithium; D002746:Chlorpromazine