Distribution and origin of acetylcholinesterase activity in the capillaries of the brain.
Areas containing AChE-positive capillaries were mapped in the brain of the cat and the guinea pig. Regions with AChE-positive capillaries mostly also contain neuronal elements with AChE activity. Electron-microscopical cytochemistry revealed localization of AChE in basement membranes of endothelial cells and pericytes very often in continuity with activity of the extracellular space. Intraendothelial AChE activity was seen only in pinocytic vesicles. The vascular AChE is thought to be of neuronal origin since no cytochemical evidence has been obtained for a synthesis of this enzyme in endothelial or other non-neuronal cells in the CNS.
D000110:Acetylcholinesterase / Q000032:analysis*; D000818:Animals; D001921:Brain / Q000098:blood supply*; D002196:Capillaries / Q000201:enzymology*; D002415:Cats; D006168:Guinea Pigs; D006651:Histocytochemistry; D014018:Tissue Distribution
D000110:Acetylcholinesterase