Noradrenergic processes involved in the locomotor effects of ethanol.
Male albino Wistar rats were depleted of forebrain noradrenaline by intracerebral injection of 4 microgram of 6-hydroxydopamine into the noradrenaline bundles in the mesencephalon. The locomotor response was examined in response to intraperitoneal injection of ethanol. The locomotor stimulation by 0.1 g/kg ethanol was not altered by the lesion, whereas the sedation found in response to 1 g/kg in controls failed to occur in the lesioned rats and instead a stimulation was seen.
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D000431:Ethanol / Q000494:pharmacology*; D006892:Hydroxydopamines / Q000494:pharmacology; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D009638:Norepinephrine / Q000502:physiology*; D051381:Rats; D013997:Time Factors
D006892:Hydroxydopamines; D000431:Ethanol; D009638:Norepinephrine