A decongestant-antihistamine mixture in the prevention of otitis media in children with colds.
One hundred four preschool-age patients in a private pediatric practice were treated prospectively during colds with either decongestant-antihistamine or placebo to determine if the decongestant-antihistamine mixture was effective in the prevention of otitis media. Each child received a standard dosage of the study medicine according to a double-blind, crossover design. Otitis media was diagnosed on the basis of clinical criteria. Fifteen (6.4%) of 234 colds treated with placebo and 14 (5.8%) of 241 colds treated with the study drug were followed by otitis. The decongestant-antihistamine mixture was not useful in preventing development of otitis media in children with colds.
D001977:Brompheniramine / Q000627:therapeutic use*; D002675:Child, Preschool; D003139:Common Cold / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D006801:Humans; D007223:Infant; D010033:Otitis Media / Q000175:diagnosis / Q000517:prevention & control*; D010665:Phenylpropanolamine / Q000627:therapeutic use*; D011725:Pyridines / Q000627:therapeutic use*
D011725:Pyridines; D010665:Phenylpropanolamine; D001977:Brompheniramine