Myelin deficiency (md): a neurologic mutant in the Wistar rat.
Myelin deficiency (md), a newly discovered neurologic mutation in the Wistar rat, is transmitted by an X-linked, recessive lethal gene. Male rats are affected, and the first symptom is a head tremor recognizable at 12 to 15 days of age. The tremors become generalized within a few days and disappear when the animal is at rest. In the later stages, from 17 to 21 days of age, the slightest disturbance will precipitate a generalized seizure. Pups die within 30 days after birth. The only gross postmortem change is a gray color of the spinal cord instead of its normally white appearance. Microscopic findings reveal total lack of myelin formation at all levels of the central nervous system.
D000818:Animals; D002490:Central Nervous System / Q000473:pathology; D005260:Female; D008297:Male; D009154:Mutation; D009185:Myelin Proteins / Q000235:genetics; D009186:Myelin Sheath / Q000235:genetics*; D009422:Nervous System Diseases / Q000175:diagnosis / Q000235:genetics; D051381:Rats / Q000235:genetics*
D009185:Myelin Proteins