Immunologic protection against the Legionnaires' disease bacterium in the AKR/J mouse.
Female AKR/J mice were challenged with the Washington strain of Legionnaires' disease (LD) bacteria. Nonimmunized mice inoculate intraperitoneally with 2 x 10(8) colony forming units became ill within 4 h and died within 24 h. Progressive histopathologic changes initiated as early as 2 h after inoculation involved the lymphoid organs, the crypts of the small intestine, and the liver. Necrosis with minimal inflammatory cell reaction was the primary lesion. Immunization with a soluble LD bacterial antigen failed to prevent illness but protected against death and development of abnormal histologic changes.
D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology*; D000942:Antigens, Bacterial / Q000008:administration & dosage*; D001419:Bacteria / Q000276:immunology*; D004195:Disease Models, Animal; D005260:Female; D007114:Immunization; D007421:Intestine, Small / Q000473:pathology; D007877:Legionnaires' Disease / Q000276:immunology* / Q000473:pathology; D007958:Leukocyte Count; D008099:Liver / Q000473:pathology; D051379:Mice; D008806:Mice, Inbred AKR / Q000276:immunology*; D009336:Necrosis; D013154:Spleen / Q000473:pathology; D013950:Thymus Gland / Q000473:pathology
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial