title: High-performance liquid chromatographic determination of cephacetrile.
abstract: A rapid and accurate quantitative determination of cephacetrile in finished bulk and dosage forms is reported. The high-performance liquid chromatographic method is free of interference by acetyl hydrolysis products and synthesis by-products. The assay can be performed in about 15 min, affording less than 0.7% coefficients of variation within and between days. The chromatographic results are in good agreement with the microbiological assay requested by the "Code of Federal Regulations" for certification of cephacetrile sodium.
mesh_terms: D002505:Cephacetrile / Q000032:analysis*; D002511:Cephalosporins / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D003640:Dealkylation; D005069:Evaluation Studies as Topic; D008722:Methods
chemical_list: D002511:Cephalosporins; D002505:Cephacetrile