Treatment of methapyrilene toxicity with physostigmine.
Methypyrilene, 40 mg/kg, was administered to male mongrel dogs, resulting in both central and peripheral anticholinergic effects. Physostigmine in doses of 0.5 to 1.0 mg was effective in reversing the central effects completely and the peripheral effects to a limited degree.
D000631:Aminopyridines / Q000506:poisoning*; D000818:Animals; D002493:Central Nervous System Diseases / Q000139:chemically induced / Q000188:drug therapy; D004285:Dogs; D008297:Male; D008701:Methapyrilene / Q000037:antagonists & inhibitors / Q000506:poisoning*; D010830:Physostigmine / Q000627:therapeutic use*
D000631:Aminopyridines; D010830:Physostigmine; D008701:Methapyrilene