title: Study of the combined and separate administration of doxorubicin and coenzyme Q10 on mouse cardiac enzymes.
abstract: Administration of an acutely toxic dose of doxorubicin to mice did not increase, but rather decreased the percent deficiency of coenzyme Q10 (CoQ10) as calculated according to the coenzyme-apoenzyme system principle. The date indicate that doxorubicin may occupy CoQ10-empty receptors on the apoenzyme, with or without some destruction of enzyme-menbrane structure close to the receptor. Data from mice receiving both CoQ10 and doxorubicin indicated that CoQ10 may protect against doxorubicin. CoQ10 alone corrected the pre-existing deficiency found in control mice.
mesh_terms: D000818:Animals; D004317:Doxorubicin / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008929:Mitochondria, Heart / Q000187:drug effects / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology*; D013385:Succinate Dehydrogenase / Q000172:deficiency / Q000378:metabolism*; D014451:Ubiquinone / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D014451:Ubiquinone; D004317:Doxorubicin; D013385:Succinate Dehydrogenase