Equilibration of peritoneal dialysis solutions during long-dwell exchanges.
There is an increasing interest in CAPD for the treatment of chronic uremia. This technique uses long-dwell peritoneal exchanges lasting 4 hr or more. We have determined equilibration curves for multiple solutes during long exchanges with commercially available 1.5% and 4.25% dextrose dialysis solutions. For small solutes, rates of change of D/P ratios fall off dramatically after 3 hr of dwell time. For larger solutes, D/P ratios change more linearly. Some concentration gradients for net removal by diffusion persist well beyond 4 hr for all but the most highly diffusible solutes. Previously reported net sieving of sodium and chloride during hypertonic exchanges is still evident after many hours.
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D003404:Creatinine / Q000378:metabolism; D005260:Female; D006801:Humans; D007444:Inulin / Q000378:metabolism; D007676:Kidney Failure, Chronic / Q000628:therapy; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis; D012964:Sodium / Q000378:metabolism; D012996:Solutions; D013997:Time Factors; D014508:Urea / Q000378:metabolism
D001786:Blood Glucose; D012996:Solutions; D014508:Urea; D007444:Inulin; D012964:Sodium; D003404:Creatinine; D002118:Calcium