[Increase of force of concentration under hypoxic conditions by glucose-insulin. Experiments in isolated papillary muscles of the guinea pig (author's transl)].
The minimally remaining force of contraction under the influence of hypoxia was measured in isolated right-ventricular papillary muscles of the guinea-pig, incubated in hypoxic (pO2 90 mm Hg) and oxygenated (pO2 630 mm Hg) buffer solution. With insulin (0.05 IE/ml) and elevated glucose (300 mg% compared to 100 mg%) the force of contraction fell to only 70 +/- 9% minimally instead of 38 +/- 11% (control, p less than 0,001). Elevated glucose or insulin alone had less pronounced effects which were not statistically significant for insulin. The results show an increase of tolerance against hypoxia of isolated papillary muscles under the influence of glucose and insulin.
D000818:Animals; D005947:Glucose / Q000494:pharmacology*; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects; D000860:Hypoxia / Q000503:physiopathology*; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology*; D009200:Myocardial Contraction / Q000187:drug effects*; D010100:Oxygen / Q000097:blood; D013997:Time Factors
D007328:Insulin; D005947:Glucose; D010100:Oxygen
Steigerung der myokardialen Kontraktionskraft unter Hypoxiebedingungen durch Glucose-Insulin. Untersuchungen am isolierten Papillarmuskel des Meerschweinchenherzens.