title: Ulcer risk in a duodeno-gastric antireflux operation in dogs.
abstract: Duodenogastric reflux is a possible pathogenetic mechanism in some type I gastric ulcers. An antireflux operation is therefore a logical procedure but involves the risk of marginal ulceration. To examine this risk, the following study was performed: 18 dogs were divided into 3 groups of 6. One group had an antireflux operation performed (AR), one had AR plus parietal cell vagotomy (AR + PCV), and the third was a control group that was given daily injections of 40 mg repository histamine. All control dogs developed ulcers after 7-84 days, mean 37 days, of histamine. Three dogs in the AR group developed ulcers spontaneously 55-92 days postoperatively, whereas none of the AR + PCV group developed ulcers spontaneously 72-108 days postoperatively. After histamine injection two of the remaining three AR dogs developed ulcers after 3-4 days of stimulation, and three of the six AR + PCV dogs developed ulcers after 4-5 days of stimulation. It is concluded that the AR operation is heavily ulcer-prone and that PCV does not protect sufficiently against ulceration.
mesh_terms: D000818:Animals; D004285:Dogs; D004386:Duodenum / Q000601:surgery*; D005746:Gastric Emptying; D005756:Gastritis / Q000209:etiology / Q000517:prevention & control; D006632:Histamine; D007583:Jejunum / Q000601:surgery*; D012306:Risk; D013276:Stomach Ulcer / Q000139:chemically induced / Q000209:etiology* / Q000517:prevention & control; D013997:Time Factors; D014628:Vagotomy
chemical_list: D006632:Histamine