title: Premature multiple Bowen's disease in poikiloderma congenitale with warty hyperkeratoses.
abstract: A constant gradual malignant degeneration of verrucous hyperkeratoses was observed in a now 16-year-old poikiloderma congenitale patient although topical immunotherapy of the warty lesions was partially successful and led to an improvement of T-cell functions.
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D001913:Bowen's Disease / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D002294:Carcinoma, Squamous Cell / Q000209:etiology*; D004137:Dinitrochlorobenzene / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications / Q000276:immunology / Q000628:therapy; D007167:Immunotherapy; D007642:Keratosis / Q000150:complications* / Q000473:pathology / Q000628:therapy; D009578:Nitrobenzenes / Q000627:therapeutic use*; D012162:Retinal Degeneration / Q000150:complications; D011038:Rothmund-Thomson Syndrome / Q000150:complications* / Q000276:immunology; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000150:complications*; D014860:Warts / Q000150:complications* / Q000473:pathology / Q000628:therapy
chemical_list: D004137:Dinitrochlorobenzene; D009578:Nitrobenzenes