Levamisole inhibits mineral mobilisation, lactate production and lysosomal enzyme release from cultured bones.
Levamisole added to cultured calvarial bones inhibited spontaneous bone resorption, as indicated by reduced release of calcium and inorganic phosphate to the medium. In addition, levamisole reduced lactate production and release of lysosomal enzymes.
D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D001862:Bone Resorption / Q000187:drug effects*; D001842:Bone and Bones / Q000201:enzymology / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D046508:Culture Techniques; D005947:Glucose / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D007773:Lactates / Q000378:metabolism; D007978:Levamisole / Q000494:pharmacology*; D008247:Lysosomes / Q000201:enzymology; D051379:Mice; D010710:Phosphates / Q000378:metabolism
D007773:Lactates; D010710:Phosphates; D007978:Levamisole; D007770:L-Lactate Dehydrogenase; D000410:Alanine Transaminase; D005947:Glucose; D002118:Calcium