Circulating Clq binding complexes in inflammatory bowel diseases.
To determine whether circulating immune complexes are present in the sera of patients with inflammatory bowel disease (IBD), a 125I-Clq binding assay was performed. Of the 55 IBD serum samples tested, the 24 ulcerative colitis samples demonstrated significant binding (33.1 +/- 8.3%, p = 0.02), whereas the 31 Crohn's samples bound essentially normal amounts (29.2 +/- 7.4%). A positive control group consisting of 27 patients with rheumatoid arthritis was also studied. Sera from 4 patients wiht IBD and colonic cancer when tested, bound 40.2 +/- 8.0% of the available 125I-Clq, while 10 patients with previous colectomies and ileostomies gave results similar to those of 15 healthy controls and 11 patients with irritable colon.
D000936:Antigen-Antibody Complex; D003093:Colitis, Ulcerative / Q000276:immunology*; D003110:Colonic Neoplasms / Q000276:immunology; D003172:Complement C1 / Q000032:analysis; D003424:Crohn Disease / Q000276:immunology*; D006801:Humans
D000936:Antigen-Antibody Complex; D003172:Complement C1