Effects of calcitonin and other hormones on bile calcium excretion in thyroparathyroidectomized rats.
The effects of calcitonin (CT) and other hormones on the bile calcium excretion after a single intraperitoneal administration of calcium (4.0 mg/100 g BW) was investigated in thyroparathyroidectomized rats. Porcine, salmon, and synthetic eel CT (80 MRCmU/100 g BW, respectively) markedly increased the bile calcium excretion in comparison with that of calcium-administered rats. Tetragastrin (7.5 microgram/100 g BW), and insulin (50 mU/100 g BW) did not alter significantly the bile calcium excretion, while epinephrine (100 microgram/100 g BW), glucagon (50 microgram/100 g BW), and parathyroid hormone (25 U/100 g BW) increased significantly. The increasable effect of CT on the bile calcium excretion was significantly prevented by epinephrine (10 and 100 microgram/100 g BW). The present results suggest that the bile calcium excretion may be increased by the hormones which causes the elevation of cyclic AMP in the liver cells of rats.
D000818:Animals; D001646:Bile / Q000032:analysis*; D002116:Calcitonin / Q000494:pharmacology*; D002118:Calcium / Q000032:analysis*; D004837:Epinephrine / Q000494:pharmacology; D008297:Male; D010280:Parathyroid Glands / Q000601:surgery*; D010281:Parathyroid Hormone / Q000494:pharmacology; D051381:Rats; D013965:Thyroidectomy
D010281:Parathyroid Hormone; D002116:Calcitonin; D002118:Calcium; D004837:Epinephrine