Fatal iron intoxication with multiple coagulation defects and degradation of factor VIII and factor XIII.
A severe iron intoxication in a 15-year-old girl resulted in profound damage to vital organs and multiple clotting defects, but no haemorrhagic diathesis. Investigation revealed not only impaired synthesis of coagulation factors but also abnormal proteolysis by plasmin as well as by other proteolytic enzymes liberated from leucocytes and damaged tissue cells affecting especially factor VIII and factor XIII.
D000293:Adolescent; D001778:Blood Coagulation Disorders / Q000139:chemically induced*; D004587:Electrophoresis, Agar Gel; D005169:Factor VIII / Q000032:analysis; D005176:Factor XIII / Q000032:analysis; D005260:Female; D006801:Humans; D007123:Immunoelectrophoresis, Two-Dimensional; D007501:Iron / Q000506:poisoning*; D007962:Leukocytes / Q000201:enzymology; D010447:Peptide Hydrolases / Q000097:blood
D005169:Factor VIII; D005176:Factor XIII; D007501:Iron; D010447:Peptide Hydrolases