Antibody responses to vaccination with WRL 105 strain live influenza vaccine in previously vaccinated and unvaccinated volunteers.
Intranasal vaccination with a single 0.5 ml dose of 10(7.0) EID 50 WRL 105 strain live influenza vaccine elicited four-fold or greater increases in circulating homotypic haemagglutinating inhibiting (HAI) antibody in 60 (64.5%) of 93 volunteers, or in 58 (74.4%) of 78 volunteers with HAI antibody titres before vaccination of less than or equal to 1/20. In comparison, in a group of volunteers vaccinated 9 months previously re-vaccination elicited antibody responses in only 4 (6.9%) of 58 volunteers, or in 3 (14.3%) of 21 volunteers with antibody titres before vaccination of less than or equal to 1/20. Titres of vaccine-induced antibody and antibody resulting from earlier natural infection appeared to fall slowly and at equivalent rates over a 9 month period.
D000328:Adult; D000914:Antibodies, Viral / Q000302:isolation & purification*; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D009980:Influenza A virus / Q000276:immunology; D007252:Influenza Vaccines / Q000276:immunology*; D008875:Middle Aged; D009975:Orthomyxoviridae / Q000276:immunology*; D013997:Time Factors
D000914:Antibodies, Viral; D007252:Influenza Vaccines