Metabolic control in diabetic patients. Effect of insulin-secretory reserve (measured by plasma C-peptide levels) and circulating insulin antibodies.
We measured circulating hemoglobin A1 (HbA1) and fasting plasma C-peptide concentrations in 100 diabetic patients. Pancreatic insulin reserve showed a negative correlation with HbA1 concentrations in nonobese, insulin-treated patients but not in obese patients, whether they were treated with insulin, oral agent, or diet alone. Patients with fasting C-peptide concentrations above 0.1 pmol/ml had significantly better metabolic control than did those with lower values. Anti-insulin antibodies were measured in 37 patients. There was no correlation between metabolic control and the affinity constants or binding capacities of these antibodies.
D000328:Adult; D000368:Aged; D002096:C-Peptide / Q000097:blood*; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000378:metabolism*; D006027:Glycosides / Q000097:blood; D006441:Hemoglobin A / Q000032:analysis; D006801:Humans; D007328:Insulin / Q000378:metabolism / Q000627:therapeutic use; D007330:Insulin Antibodies / Q000032:analysis*; D008875:Middle Aged; D009765:Obesity; D010455:Peptides / Q000097:blood*
D002096:C-Peptide; D006027:Glycosides; D007328:Insulin; D007330:Insulin Antibodies; D010455:Peptides; D006441:Hemoglobin A