Phenothiazine-induced dystonia associated with an increase in serum creatine phosphokinase.
A transient but considerable rise in serum creatine phosphokinase (CPK) levels occurred in six boys aged between 8 and 11 years and suffering from phenothiazine-induced dystonia. In one boy (Case 4), after the CPK level had returned to normal after withdrawal of the drug, its reintroduction orally at lower dosage caused a slight increase in the level of CPK in the absence of any recurrence of the dystonia.
D002648:Child; D003402:Creatine Kinase / Q000097:blood*; D004421:Dystonia / Q000139:chemically induced* / Q000201:enzymology; D006801:Humans; D008297:Male; D010640:Phenothiazines / Q000009:adverse effects*
D010640:Phenothiazines; D003402:Creatine Kinase