Gastin cells and fasting gastrin levels in duodenal ulcer patients: a quantitative study based on multiple biopsy specimens.
The number of gastrin-producing cells in biopsy specimens from the gastric and duodenal mucosae in 19 duodenal ulcer patients was quantitated using a morphometric method. The level of immunoreactive gastrin in a sample of fasting serum obtained at the time of the biopsy was measured by radioimmunoassay. The results show no significant difference when compared with those from a group of normal control volunteers. Moreover, there was no correlation between the numbers of gastrin-producing cells and the fasting serum gastrin level in either controls or duodenal ulcer patients.
D000293:Adolescent; D000328:Adult; D001706:Biopsy; D002452:Cell Count; D004381:Duodenal Ulcer / Q000097:blood / Q000473:pathology*; D004386:Duodenum / Q000473:pathology; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology*; D005755:Gastrins / Q000096:biosynthesis / Q000097:blood*; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology; D008297:Male; D008875:Middle Aged
D005755:Gastrins