Age-related decrease of ultraviolet light-induced DNA repair synthesis in human peripheral leukocytes.
The capacity for ultraviolet light-induced DNA repair synthesis, studied in peripheral leukocytes from 58 healthy subjects 13 to 94 years old, was found to vary greatly between individuals. A negative, statistically significant correlation was obtained between age and this synthesis, indicating a decrease in repair capacity with age. An age-related decrease in DNA repair may increase the susceptibility of cells to agents causing DNA damage, i.e. carcinogens and certain cytostatic drugs.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging; D004247:DNA / Q000096:biosynthesis; D004260:DNA Repair / Q000528:radiation effects*; D006801:Humans; D007962:Leukocytes / Q000378:metabolism* / Q000528:radiation effects; D008214:Lymphocytes / Q000378:metabolism / Q000528:radiation effects; D008875:Middle Aged; D014466:Ultraviolet Rays
D004247:DNA