Cis-platinum(II) diamine dichloride causes mutation, transformation, and sister-chromatid exchanges in cultured mammalian cells.
The anti-tumor agent cis-platinum(II) diamine dichloride caused dose-dependent toxicity in V79 Chinese hamster cells and in secondary Syrian hamster embryo cells. Chromosome aberrations were induced and positive dose--response relationships were observed for induction of sister-chromatid exchanges and 6-thioguanine-resistant mutations in V79 cells and morphologic transformation of secondary Syrian hamster embryo cells. The findings suggest that this chemical is a potential human carcinogen.
D000818:Animals; D002460:Cell Line; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects*; D002945:Cisplatin / Q000494:pharmacology*; D006224:Cricetinae; D003434:Crossing Over, Genetic; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004622:Embryo, Mammalian; D008647:Mesocricetus; D009153:Mutagens
D009153:Mutagens; D002945:Cisplatin