Negative effects of oral fatty acid supplementation on sweat chloride in cystic fibrosis.
Essential fatty acid supplementation with oral safflower oil (1 gm/kg/day) to 11 cystic fibrosis patients (aged 6 months to 14 years) for one year produced no significant change in sweat chloride concentration (mEq/liter) or sweat rate (gm/min/m2), Addition of vitamin E (10 mg/kg/day) to the safflower oil had no effect on sweat chloride concentration or rate compared to placebo. No clinical improvement could be detected compared to a control group. These results do not support previous reports of the effects of fatty acid supplementation on sweat electrolyte concentrations in cystic fibrosis.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000097:blood / Q000188:drug therapy / Q000378:metabolism*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009821:Oils / Q000494:pharmacology*; D011458:Prostaglandins E / Q000097:blood; D011460:Prostaglandins F / Q000097:blood; D012450:Safflower Oil / Q000494:pharmacology*; D012965:Sodium Chloride / Q000032:analysis*; D013542:Sweat / Q000032:analysis* / Q000187:drug effects
D009821:Oils; D011458:Prostaglandins E; D011460:Prostaglandins F; D012965:Sodium Chloride; D012450:Safflower Oil