Effects of 1 alpha,25-dihydroxycholecalciferol on disuse osteoporosis in the dog: a histomorphometric study.
Disuse osteoporosis was produced in dogs by immobilization of the left rear limb in a plaster cast. The trabecular bone volume of the calcaneus was then determined following treatment with 1 alpha,25-dihydroxycholecalciferol for 4 weeks with oral dosages of 60 to 240 ng/kg of body weight. The trabecular bone volume percentage of the immobilized calcaneus was in direct relation to the dosage of 1 alpha,25-dihydroxycholecalciferol.
D000818:Animals; D002111:Calcaneus / Q000473:pathology; D002118:Calcium / Q000097:blood; D004100:Dihydroxycholecalciferols / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy* / Q000473:pathology; D004285:Dogs; D006887:Hydroxycholecalciferols / Q000627:therapeutic use*; D010024:Osteoporosis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*
D004100:Dihydroxycholecalciferols; D006887:Hydroxycholecalciferols; D002118:Calcium