title: [Effect of urethane and penthobarbital on the behaviour of the renin-angiotensin-system in rat (author's transl)].
abstract: The behaviour of the renin-angiotensin-system was investigated after urethane and penthobarbital anaesthesia in rats. The recent results support the early observation that urethane increases the plasma-renin-activity and the haematocrit. It was further shown that urethane in the customary anaesthetic dose causes hypoproteinaemia and a decrease in the pressor response to angiotensin and in renin substrate concentration. Based on these results, its use as an anaesthetic in experiments connected with the renin-angiotensin-system does not appear to be appropriate.
mesh_terms: D000758:Anesthesia; D000804:Angiotensin II / Q000097:blood* / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology*; D011311:Pressoreceptors / Q000187:drug effects; D051381:Rats; D012083:Renin / Q000097:blood*; D014520:Urethane / Q000494:pharmacology*
chemical_list: D000804:Angiotensin II; D014520:Urethane; D012083:Renin; D010424:Pentobarbital
vernacular_title: Vergleichende Untersuchungen des Renin-Angiotensin-Systems nach Urethan- und Penthobarbitalnarkose.