Relation of HVH-II to carcinoma of the cervix.
An animal model is described that demonstrates the development of varying degrees of basal cell hyperplasia, metaplasia, and dysplasia following cervicovaginal herpesvirus hominis type II (HVH-II) infection. Although the study spanned a period of 30 months, the equivalent of 60 human years, there was no evidence of anaplasia. These results are considered in relation to the role of HVH-II as an initiator in the multistep process leading to cervical carcinoma.
D000818:Animals; D002584:Cervix Uteri / Q000473:pathology; D004195:Disease Models, Animal; D005260:Female; D006561:Herpes Simplex / Q000150:complications* / Q000473:pathology; D006965:Hyperplasia; D008679:Metaplasia; D011230:Precancerous Conditions; D051381:Rats; D002577:Uterine Cervical Diseases / Q000150:complications / Q000473:pathology; D002578:Uterine Cervical Dysplasia / Q000209:etiology; D002583:Uterine Cervical Neoplasms / Q000209:etiology* / Q000473:pathology; D014623:Vaginal Diseases / Q000150:complications / Q000473:pathology