Diazinon and porphyria cutanea tarda.
Cutaneous application of diazinon to rats over a period of 12 weeks gives rise to a condition biochemically indistinguishable from porphyria cutanea tarda. Faecal porphyrin levels are elevated with the appearance of isocoproporphyrin in the faeces. Oral administration of diazinon does not appear to cause any disturbance of porphyrin metabolism.
D000284:Administration, Oral; D000818:Animals; D003976:Diazinon / Q000378:metabolism / Q000633:toxicity*; D005243:Feces / Q000032:analysis; D005260:Female; D007306:Insecticides / Q000633:toxicity*; D009824:Ointments; D011164:Porphyrias / Q000139:chemically induced* / Q000378:metabolism; D011166:Porphyrins / Q000032:analysis / Q000652:urine; D051381:Rats
D007306:Insecticides; D009824:Ointments; D011166:Porphyrins; D003976:Diazinon