title: Craniofacial growth following experimental craniosynostosis and craniectomy in rabbits.
abstract: Premature fusion of the coronal suture was produced in 9-day-old rabbits by immobilization of the suture area bilaterally with methyl-cyanoacrylate adhesive. The effects of suture fusion and its surgical release on suture growth and on skull morphology were evaluated by radiographic cephalometry. Immobilization resulted in significant changes in the angular dimensions in the vault toward an anteroposterior shortening. No permanent deformity was observed in the angular relationship between the cranial base and the facial skeleton. Craniectomy at 30 days, when a skull deformity had been established, resulted in rapid separation of the bones at the suture site which returned the deformed skull to a normal configuration by 90 days of age. Surgical removal of a normal suture in a control group also resulted in accelerated separation of the bones at the excised suture site, but it was less than after removal of an immobilized suture. The experimental data indicate that premature fusion of rapidly growing sutures results in consistent skull deformity. Early release of the fusion, when this is the primary abnormality, will result in spontaneous correction of the deformity.
mesh_terms: D000367:Age Factors; D000818:Animals; D002508:Cephalometry; D003398:Craniosynostoses / Q000150:complications*; D003487:Cyanoacrylates; D004195:Disease Models, Animal; D008445:Maxillofacial Development; D011817:Rabbits; D011859:Radiography; D012886:Skull / Q000000981:diagnostic imaging / Q000254:growth & development* / Q000601:surgery; D014014:Tissue Adhesives
chemical_list: D003487:Cyanoacrylates; D014014:Tissue Adhesives