[Biological activity of exogenous DNA in rat thymocytes].
The thymocyte's viability and hybridization of one fraction thymocyte RNA with exogenous DNA have been studied after the incubation of cells with this DNA. The exogenous DNA decreases the number of viable cells and increases the hybridization percentage of pulse-labeled RNA. The above changes failed to be induced after the incubation of these cells with the complex DNA with actinomycin D, despite the fact that this complex penetrates into the cells as easily as does the free DNA.
D000818:Animals; D002417:Cattle; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004247:DNA / Q000378:metabolism / Q000494:pharmacology*; D003609:Dactinomycin / Q000494:pharmacology; D004347:Drug Interactions; D066298:In Vitro Techniques; D009693:Nucleic Acid Hybridization; D011485:Protein Binding / Q000187:drug effects; D011489:Protein Denaturation; D012313:RNA / Q000378:metabolism; D051381:Rats; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects* / Q000528:radiation effects
D003609:Dactinomycin; D012313:RNA; D004247:DNA
Biologicheskaia aktivnost' ékzogennoĭ DNK v timotsitakh krys.