Obstetric history of diabetics: its relevance to the aetiology of diabetes.
The birth weights of infants born to patients with insulin-dependent diabetes (IDD) and insulin-independent diabetes (IID) before the disease was diagnosed were compared. An appreciable excess of infants above the 90th centile for weight was found, the proportions being 27% of infants born to mothers with IDD and 30% of those born to mothers with IID. These findings suggest that many patients with both types of diabetes have a prolonged period of metabolic abnormality before overt symptoms of diabetes arise and that the apparent acute onset of the disease in patients who are insulin dependent is illusory.
D000328:Adult; D000368:Aged; D001724:Birth Weight; D003920:Diabetes Mellitus / Q000175:diagnosis / Q000209:etiology*; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008875:Middle Aged; D009765:Obesity; D011236:Prediabetic State / Q000378:metabolism*; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000378:metabolism; D013997:Time Factors; D006113:United Kingdom