Methotrexate for psoriasis-revisited.
If maximum medical management-hospitalization, tar and sunlight therapy, topical steroids with plastic-wrap occlusion--is not effective, and PUVA is not available, methotrexate therapy should be considered, especially in a patient with severe psoriatic arthritis. It should be used if systemic steroids are inadvisable and if the patient has a normal liver biopsy and no history of alcohol excess. The least toxic and most effective method of administration is three divided doses every 12 hours, once a week.
D000328:Adult; D001168:Arthritis / Q000150:complications; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000627:therapeutic use*; D011565:Psoriasis / Q000188:drug therapy*
D008727:Methotrexate