title: Carcinogenicity of oil shale tars, some of their components, and commercial products.
abstract: Bioassays for carcinogenicity of various primary processing products (crude oils or tars) and commercial products obtained from Estorian oil shale have been carried out since 1951. The products (undiluted or diluted) were painted twice weekly 50 times on the interscapular area of the skin of random-bred or CC57Br mice. The products processed at high temperatures have a higher carcinogenic activity. Blends of products containing over 10% of high temperature crude oil (chamber furnace oil) have about the same carcinogenic activity as the latter. There is no strict correlation between the concentration of benzo(a)pyrene (BP) in oil shale products and their carcinogenic activity. Determination of BP in such products can serve as an approximate estimate of carcinogenic properties. The results of animal experiments with chromatographic fractions of the high temperature shale oil demonstrated the presence of compounds which lengthen the latency period of the carcinogenic effect of BP in the aromatic fraction of this oil as well as other carcinogens and compounds enhancing the activity of carcinogenic compounds. Under industrial conditions, contact of workers with carcinogenic shale oils can be reduced by means of coking the carcinogenic oils, which results in production of solid coke and of distillate which is recycled. Medical vaseline potentiates the carcinogenic action of BP and similar compounds. Dilution of shale oils with oils containing aliphatic hydrocarbons cannot be considered as diminution of the carcinogenic potency of these products.
mesh_terms: D000818:Animals; D001681:Biological Assay; D002273:Carcinogens; D004957:Estonia; D005648:Fuel Oils; D006358:Hot Temperature; D051379:Mice; D010578:Petroleum; D012878:Skin Neoplasms / Q000139:chemically induced*; D013638:Tars; D013997:Time Factors
chemical_list: D002273:Carcinogens; D005648:Fuel Oils; D010578:Petroleum; D013638:Tars