title: Placental histopathology of midtrimester termination.
abstract: Placentas spontaneously passed after second-trimester terminations of pregnancy using either hypertonic sodium chloride or hyperosmolar urea plus prostaglandin F2alpha (PGF2alpha) were examined to determine histologic characteristics. The placentas of hypertonic sodium chloride terminations demonstrated a type of "coagulation necrosis" that has been described previously, while placentas of pregnancies terminated by hyperosmolar urea plus PGF2alpha showed a similar pattern in about one half the cases but a histologic pattern of less severe damage in the remaining cases. The 2 groups showed no significant differences when characteristics such as injection-abortion interval or estimated hypertonicity of the fluid were examined.
mesh_terms: D000028:Abortion, Induced; D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D009994:Osmolar Concentration; D010920:Placenta / Q000473:pathology*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011460:Prostaglandins F / Q000627:therapeutic use; D012462:Saline Solution, Hypertonic / Q000627:therapeutic use; D014508:Urea / Q000627:therapeutic use
chemical_list: D011460:Prostaglandins F; D012462:Saline Solution, Hypertonic; D014508:Urea