title: Prevention of protein extravasation in the brain by an anion transport inhibitor in acute experimental hypertension in rats.
abstract: Acute experimental hypertension induces protein leakage in the brain. The protein is thought to be, at least to a great extent, transported through the endothelial cells by pinocytosis. An anion transport inhibitor, 4 acetamido-4-isothiocyano-stilbene-2,2'-disulfonic acid, markedly reduced adrenaline or bicuculline-induced leakage of 125IHSA and Evans blue-albumin in all areas of the rat brain. The preventive effect of dexamethasone was less pronounced and no effect was seen of haloperidol.
mesh_terms: D000208:Acute Disease; D000818:Animals; D000838:Anions; D001640:Bicuculline / Q000494:pharmacology; D001798:Blood Proteins / Q000378:metabolism*; D001812:Blood-Brain Barrier / Q000187:drug effects; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis; D003907:Dexamethasone / Q000494:pharmacology; D004727:Endothelium / Q000378:metabolism; D004837:Epinephrine / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology; D006973:Hypertension / Q000378:metabolism*; D008297:Male; D010873:Pinocytosis / Q000187:drug effects; D051381:Rats; D012711:Serum Albumin, Radio-Iodinated / Q000134:cerebrospinal fluid; D013267:Stilbenes / Q000494:pharmacology*
chemical_list: D000838:Anions; D001798:Blood Proteins; D002556:Cerebrospinal Fluid Proteins; D012711:Serum Albumin, Radio-Iodinated; D013267:Stilbenes; D003907:Dexamethasone; D006220:Haloperidol; D001640:Bicuculline; D004837:Epinephrine