title: Physiological cell death of secretory ameloblasts in the rat incisor.
abstract: The migration of the ameloblasts in the continuously erupting incisors of the rat is accompanied by cell loss. Ameloblasts degenerate near the mesial and lateral cemento-enamel junctions in the secretory zone and in the middle two thirds of the region of postsecretory transition, degeneration being most marked where these areas merge. These findings support the hypothesis that the prism decussation in the enamel results from alternating transverse rows of secretory ameloblasts sliding past each other whilst elaborating their rods. The distribution of the degenerating cells suggests, however, that the sliding cell rows are not exactly transverse but arcuate, with the opening facing incisally. The progress of structural alterations of the nuclei in the degenerating ameloblasts appears to follow the pattern earlier described in vinblastine-damaged ameloblasts.
mesh_terms: D000565:Ameloblasts / Q000648:ultrastructure*; D000818:Animals; D002465:Cell Movement; D002467:Cell Nucleus / Q000648:ultrastructure; D002470:Cell Survival; D007180:Incisor / Q000648:ultrastructure*; D008854:Microscopy, Electron; D051381:Rats