A two and one half year clinical experience with a mechanical left ventricular assist pump in the treatment of profound postoperative heart failure.
A sac-type paracorporeal left ventricular assist pump was implanted in 9 patients suffering from profound left ventricular failure following open heart surgery. Two patients had good recovery of left ventricular function and were weaned from assist. One survived 14 months postoperatively. Primary causes of death among the remaining patients were (1) primary right ventricular failure, (2) assist pump inlet cannula obstruction and (3) excessive bleeding. The strategies developed or proposed to deal with these problems include, respectively: (1) biventricular assist for patients with concomitant right ventricular failure; (2) cannulation of the left atrium to avoid inlet cannula obstruction by the left ventricular wall and intraventricular septum; (3) more rapid selection of left assist candidates and more rapid implantation techniques to reduce the coagulopathy associated with prolonged cardiopulmonary bypass, and an effective autotransfusion system to augment blood replacement.
D000328:Adult; D000368:Aged; D000818:Animals; D001243:Assisted Circulation / Q000295:instrumentation*; D002315:Cardiopulmonary Bypass / Q000009:adverse effects; D002417:Cattle; D005260:Female; D006333:Heart Failure / Q000503:physiopathology / Q000601:surgery*; D006352:Heart Ventricles / Q000503:physiopathology / Q000601:surgery; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D013599:Systole