The respiratory effects of dezocine and pentazocine in man.
The respiratory effects of dezocine and pentazocine were studied in five volunteers. Based on their effects over a 3-hour period, it was found that dezocine was 8.6 times as potent as pentazocine in terms of their respiratory depressant effects. The clinical significance of these findings remains to be determined.
D000700:Analgesics / Q000494:pharmacology*; D001952:Bridged-Ring Compounds / Q000494:pharmacology*; D002245:Carbon Dioxide / Q000378:metabolism; D003516:Cycloparaffins / Q000494:pharmacology*; D003864:Depression, Chemical; D006801:Humans; D008297:Male; D009292:Narcotic Antagonists / Q000494:pharmacology*; D010423:Pentazocine / Q000494:pharmacology*; D012119:Respiration / Q000187:drug effects*; D013997:Time Factors
D000700:Analgesics; D001952:Bridged-Ring Compounds; D003516:Cycloparaffins; D009292:Narcotic Antagonists; D002245:Carbon Dioxide; D010423:Pentazocine