Influence of hypoxia on the composition of isolated edema fluid in cold-induced brain edema.
The isolation of edema fluid from cats with cold-induced cerebral edema allowed the study of changes of Na+ and K+ content, lactate dehydrogenase and creatine phosphokinase activity, colloid osmotic pressure and the level of intravenously administered 99mTc-albumin in the edema fluid during a period of hypoxia. The changes consisted of an increase of all mentioned parameters, except Na+; and could be interpreted as a concentration of solutes (but for Na+) in the extracellular edema fluid, concomitant to a reduction of the extracellular space, as the oxygen deficiency caused improper functioning of the cellular Na+-K+ pump, with a resulting shift of fluid (including Na+) into the cellular elements.
D000418:Albumins / Q000032:analysis; D000818:Animals; D001826:Body Fluids / Q000032:analysis*; D001929:Brain Edema / Q000134:cerebrospinal fluid / Q000150:complications / Q000378:metabolism*; D002415:Cats; D003080:Cold Temperature; D003102:Colloids; D003402:Creatine Kinase / Q000032:analysis; D000860:Hypoxia / Q000150:complications / Q000378:metabolism*; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D009997:Osmotic Pressure; D011188:Potassium / Q000032:analysis; D012964:Sodium / Q000032:analysis
D000418:Albumins; D003102:Colloids; D012964:Sodium; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase; D011188:Potassium