title: [Multiple effects of resorcinol on thyroid function (author's transl)].
abstract: In rats, I.V. injected resorcinol led to a decrease in thyroid radioiodine uptake and labelled iodothyronine/iodotyrosine ratio with no changes in the percent of thyroidal labelled iodide or radioiodine release. When thyroid lobes were incubated in vitro with radioiodine, resorcinol concentrations from 10(-3)M to 10(-6)M gave an increase in the percent of thyroidal labelled iodide and iodotyrosine/iodothyronine ratio. In animals fed 5% resorcinol for 2 weeks we observed an increase in thyroid weight, a decrease in plasma T4, no change in the percent of free T4, a decrease in T4 half life and no significant changes in T3 half life. Thyroidal labelled MIT/DIT and T3/T4  atios increased. Resorcinol, given in diet during 5 days to rats which had a low thyroidal thyroglobulin content after PTU administration for 2 weeks, gave, in comparison with rats fed PTU only, an increase in thyroidal thyroglobulin/DNA ratio and a decrease in thyroidal radioiodine release contrasting with an increase in plasma TSH. These differences did not exist when resorcinol was given for one month.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D066298:In Vitro Techniques; D007275:Injections, Intravenous; D007455:Iodine / Q000378:metabolism; D051381:Rats; D012118:Resorcinols / Q000008:administration & dosage / Q000494:pharmacology*; D013961:Thyroid Gland / Q000187:drug effects* / Q000378:metabolism
chemical_list: D012118:Resorcinols; D007455:Iodine
vernacular_title: Effets multiples du resorcinol sur la fonction thyroïdienne.