Effect of dichloromethane on the sciatic motor conduction velocity of rats.
There is a correlation between dichloromethane dosis (X) of 1--6 mmole/kg administered i.p. to rats and the sciatic motor conduction velocity (Y): Y = 57.1--1.091 X. The correlation coefficient 'r' is 0.437 (p less than 0.01). Presumably, the decrease of nerve conduction velocity is caused by the endogenous carbon monoxide production due to dichloromethane biotransformation.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D006843:Hydrocarbons, Chlorinated / Q000494:pharmacology*; D008297:Male; D008752:Methylene Chloride / Q000097:blood / Q000494:pharmacology*; D009431:Neural Conduction / Q000187:drug effects*; D051381:Rats; D012584:Sciatic Nerve / Q000187:drug effects* / Q000502:physiology
D006843:Hydrocarbons, Chlorinated; D008752:Methylene Chloride