Further investigations on possible correlation between agglutinability and osteoinductive properties of established cell lines.
Various cell lines, including SV40 virus-transformed human and mouse fibroblasts, established fibroblastic and epithelial cell lines, as well as their hybrids were tested for osteoinductive properties versus presence of Concanavalin A receptors. No correlation was found between the presence of these receptors and osteoinductive properties of cells. So far, however, no osteoinductive cell line was found without Concanavalin A receptors. Thus, the significance of surface properties of cells in transmission of osteoinductive signal(s) remains an open question. None of the fibroblastic lines exhibits osteoinductive potential, in contrast to the HT-40 and WISH epithelial lines.
D000818:Animals; D001846:Bone Development; D002449:Cell Aggregation / Q000187:drug effects; D002460:Cell Line; D002462:Cell Membrane / Q000502:physiology; D003208:Concanavalin A / Q000494:pharmacology; D006801:Humans; D051379:Mice; D010835:Phytohemagglutinins / Q000494:pharmacology; D011952:Receptors, Concanavalin A / Q000032:analysis*; D011955:Receptors, Drug / Q000032:analysis*
D010835:Phytohemagglutinins; D011952:Receptors, Concanavalin A; D011955:Receptors, Drug; D003208:Concanavalin A