[Comparison of the analgesic effect of nicomorphine in two different solutions (author's transl)].
The analgesic effect of nicomorphine in two different solutions was tested in 120 patients after cholecystectomy. The patients were divided into three groups: group I was given nicomorphine diluted with water, group II nicomorphine diluted with propylenglykol, group III propylenglykol alone. The degree of pain sensation was determined by interrogation. Pulse, respiratory rate, blood pressure as well as capillary pO2 and pCO2 were measured 10 and 30 minutes after medication. No difference in pain relief could be established in the two groups receiving nicomorphine. Respiratory depression with a significant decrease of respiratory rate together with an increase of pCO2 was observed in the two nicomorphine groups. In the placebo group there was no significant change in the tested parameters. A small decrease of pO2 was observed in all patients after laparotomy.
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood; D002763:Cholecystectomy; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D009022:Morphine Derivatives / Q000008:administration & dosage*; D009539:Nicotinic Acids / Q000008:administration & dosage; D010100:Oxygen / Q000097:blood; D010149:Postoperative Pain / Q000188:drug therapy*; D011409:Propylene Glycols; D011674:Pulse / Q000187:drug effects; D012119:Respiration / Q000187:drug effects; D012996:Solutions; D014867:Water
D009022:Morphine Derivatives; D009539:Nicotinic Acids; D011409:Propylene Glycols; D012996:Solutions; D014867:Water; D002245:Carbon Dioxide; D010100:Oxygen; C008549:nicomorphine
Vergleich der analgetischen Wirkung von Nicomorphin in zwei verschiedenen Lösungen.