Capsimycin, a new antibiotic. I. Production, isolation and properties.
Capsimycin is a new antifungal antibiotic produced by a strain of Streptomyces sp. C 49--87. The active substance in the fermented broth was isolated by solvent extraction followed by silica gel column chromatography. The antibiotic melts at 186 degrees C (decomp.) and has a molecular formula C30H40N2O6. It exhibits marked inhibitory activity against Phytophthora capsici (Leaf blight disease of cucumber) and Pythium debaryanum (Damping-off disease of cucumber).
D000818:Animals; D000935:Antifungal Agents / Q000032:analysis / Q000096:biosynthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005658:Fungi / Q000187:drug effects; D007928:Lethal Dose 50; D051379:Mice; D008970:Molecular Weight
D000935:Antifungal Agents