title: Rank order of sarcoma susceptibility among mouse strains reverses with low concentrations of carcinogen.
abstract: Ten mouse strains in which aryl hydrocarbon hydroxylase can be induced, or F1 hybrids of these strains, were ranked according to their sarcoma susceptibility when exposed to a high concentration (5 percent) of the chemical carcinogen 3-methylcholanthrene. This rank order was reversed when the concentration of 3-methylcholanthrene was reduced to 0.05 percent.
mesh_terms: D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D005796:Genes; D008297:Male; D008748:Methylcholanthrene; D051379:Mice; D008815:Mice, Inbred Strains / Q000502:physiology*; D012513:Sarcoma, Experimental / Q000139:chemically induced* / Q000276:immunology
chemical_list: D008748:Methylcholanthrene; D001189:Aryl Hydrocarbon Hydroxylases