Hemodynamic adjustments in hypertensive patients developing circulatory congestion during beta-adrenergic blockade.
In the course of chronic treatment with a cardioselective beta-blocking agent (atenolol) 6 patients out of a series of 38 hypertensives developed signs of circulatory congestion. In spite of this, maximal exercise capacity was maintained. This resulted from hemodynamic readjustments at rest and exercise, where an increase in stroke volume played a major role.
D000328:Adult; D000368:Aged; D001262:Atenolol / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D004341:Drug Evaluation; D005260:Female; D006333:Heart Failure / Q000139:chemically induced*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007773:Lactates / Q000097:blood; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption / Q000187:drug effects; D005082:Physical Exertion; D011412:Propanolamines / Q000009:adverse effects*; D014655:Vascular Resistance / Q000187:drug effects
D007773:Lactates; D011412:Propanolamines; D001262:Atenolol