[Reactive immunologic changes during intraarterial methotrexate therapy in patients with carcinoma of the oropharynx (author's transl)].
The immunity deficiency as colateral effect of intra arterial therapy with methotrexate in oropharynx carcinoma was measured by lymphocyte stimulation tests. Ten patients taken in two groups were treated with different doses of methotrexate and citrovorum factor. In determined stages of the cellular cycle an extensive reactive trauma to the lymphocytes was detected. This is not the case in the usual measurement of the number of lymphocytes, leucocytes and thrombocytes. This method seems to be appropriate in order to establish the doses, period of time and frequency for application of the intra arterial perfusion with methotrexate.
D000328:Adult; D000368:Aged; D006801:Humans; D007165:Immunosuppression Therapy; D007958:Leukocyte Count; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D008727:Methotrexate / Q000494:pharmacology / Q000627:therapeutic use*; D008875:Middle Aged; D008934:Mitogens / Q000494:pharmacology; D009062:Mouth Neoplasms / Q000188:drug therapy / Q000276:immunology*; D010610:Pharyngeal Neoplasms / Q000188:drug therapy / Q000276:immunology*; D013268:Stimulation, Chemical
D008934:Mitogens; D008727:Methotrexate
Veränderungen der immunologischen Reaktivität bei Patienten mit Oropharynxkarzinomen unter intra-arterieller Methotrexattherapie.