Congenital glaucoma: genetic models.
Modes of inheritance of congenital glaucoma have been studied. Two methods of analysis, complex segregation analysis and frequency of congenital glaucoma in second- and third-degree relatives, did not permit one to retain a unitary mode of inheritance ofthis malformation. Genetic heterogeneity of congenital glaucoma is proposed. Recurrence risks and guidelines for genetic counseling in specified situations are given.
D000328:Adult; D000483:Alleles; D002648:Child; D002874:Chromosome Mapping; D005260:Female; D005799:Genes, Dominant; D005808:Genes, Recessive; D005817:Genetic Counseling; D005901:Glaucoma / Q000151:congenital* / Q000235:genetics; D006801:Humans; D008297:Male; D008954:Models, Biological; D010375:Pedigree; D012306:Risk; D012744:Sex Ratio