[Hypervitaminosis A and the state of the chromosome apparatus of the rat bone marrow cells].
In experiments on rats overdoses of vitamin A produced an increased frequency of cells with chromosomal aberrations and elevated number of polyploid cells. Still more pronounced disturbances were recorded in the structure and ploidity of chromosomes if hypervitaminosis A was accompanied by deficient protein nutrition.
D000782:Aneuploidy; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects*; D008677:Metaphase / Q000187:drug effects; D011123:Polyploidy; D051381:Rats; D013997:Time Factors; D014801:Vitamin A / Q000008:administration & dosage / Q000009:adverse effects*
D014801:Vitamin A
Gipervitaminoz A i sostoianie khromosomnogo apparata kletok kostnogo mozga u krys.