title: The effects of graded experimental trauma on cerebral blood flow and responsiveness to CO2.
abstract: The effects of graded mechanical cerebral trauma on cerebrovascular reactivity to CO2 was studied in 26 cats. A fluid-wave percussion model was employed which delivered an epidural trauma of fixed duration and variable amplitude. The animals were maintained at arterial normoxia, with constant monitoring of intracranial and systemic arterial pressures, electroencephalograms, and end-tidal CO2. Following trauma, cerebral blood flow was measured using the H2 ion clearance technique at PaCO2 levels ranging sequentially from 20 to 60 mm Hg. Cerebrovascular reactivity for control animals (uninjured) was 2.7%. In the group with mild trauma (0.76 to 1.90 atm) reactivity was impaired (1.7%), and it was abolished in the severely injured group (2.90 to 4.60 atm). Mild injuries did not alter resting blood flows, while severe trauma resulted in a significant decrease in cerebrovascular resistance. Intracranial and systemic arterial pressures were altered proportionately to the level of cerebral injury. The authors propose that trauma to the brain-stem vasoregulatory centers accounts for these findings.
mesh_terms: D000818:Animals; D001794:Blood Pressure; D001921:Brain / Q000473:pathology; D001930:Brain Injuries / Q000473:pathology / Q000503:physiopathology*; D002245:Carbon Dioxide / Q000097:blood*; D002415:Cats; D002560:Cerebrovascular Circulation; D006259:Craniocerebral Trauma / Q000503:physiopathology; D007427:Intracranial Pressure; D010313:Partial Pressure; D014655:Vascular Resistance
chemical_list: D002245:Carbon Dioxide