title: Growth mechanisms in skulls with facial clefts. Descriptive and experimental studies on the facial skeleton.
abstract: During postnatal growth, skulls of patients with untreated unilateral clefts of the alveolus and palate develop additional anomalies of the facial skeleton. Similar anomalies--a deviation of the upper jaw to the non-cleft side and retropositioning of the maxilla on the cleft side--develop in rabbits with the same type of cleft, surgically produced in the fourth week after birth. Based on a quantitative study of the postnatal growth of the rabbit skull under normal and various experimental conditions, a mechanisms is proposed for the late developement of anomalies of the facial skeleton in cleft-affected skulls.
mesh_terms: D000015:Abnormalities, Multiple / Q000209:etiology; D000367:Age Factors; D000539:Alveolar Process / Q000002:abnormalities*; D000818:Animals; D002972:Cleft Palate / Q000150:complications*; D008437:Maxilla / Q000002:abnormalities*; D008445:Maxillofacial Development; D010159:Palate / Q000002:abnormalities*; D011817:Rabbits