Production of 3-acetoxyscirpene-4,15-diol from anguidine (4,15-diacetoxyscirpene-3-ol) by Fusarium oxysporum f.sp. vasinfectum.
Growing cells of Fusarium oxysporum f.sp. vasinfectum (ATCC 7808) formed 3-acetoxyscirpene-4,15-diol from anguidine (4,15-diacetoxyscirpene-3-ol) by way of the intermediates triacetoxyscirpene, 3,4-diacetoxyscirpene-15-ol and 3,15-diacetoxyscirpene-4-ol. The new 3-acetoxy analog was found to be less active than anguidine and the other monoacetoxy derivatives when tested against a series of fungal strains and against HeLa cells in vitro.
D000903:Antibiotics, Antineoplastic / Q000378:metabolism*; D055598:Chemical Phenomena; D002621:Chemistry; D005658:Fungi / Q000187:drug effects; D005670:Fusarium / Q000378:metabolism*; D006367:HeLa Cells / Q000187:drug effects; D013045:Species Specificity; D014255:Trichothecenes
D000903:Antibiotics, Antineoplastic; D014255:Trichothecenes; C019233:3-acetoxyscirpene-4,15-diol