Complement activation by rat platelets: its significance to inflammation in the rat.
Generation of chemotactic activity in rat plasma or serum by aggregated rat platelets or by an extract of lysed platelets has been demonstrated. Chemotactic activity was not generated from serum either in the absence of an intact complement system or by platelet lysate pre-incubated with soya bean trypsin inhibitor. The significance of these observations is discussed in relation to some recent work on the role of platelets in inflammation.
D000818:Animals; D001792:Blood Platelets / Q000502:physiology*; D002634:Chemotaxis, Leukocyte; D003167:Complement Activation; D003182:Complement C5 / Q000378:metabolism*; D005260:Female; D007249:Inflammation / Q000097:blood / Q000276:immunology*; D051381:Rats
D003182:Complement C5