title: [Study of pharmacological activity of potassium glutamate in an experiment on young and old animals].
abstract: It was established that potassium glutaminate is a little toxic compound (LD50 amounts to 4500 mg/kg on administration to white mice by mouth) and shows a marked pharmacological activity. Administration of potassium glutaminate to white rats in a dose 500 mg/kg raises intracellular potassium level in the tissues, makes the acid-balance equilibrium return to normal after unilateral nephrectomy and acid load, activates bile-forming and choleretic liver function, exerts a moderate diuretic effect. The compound potentiates the activity of succinate dehydrogenase and cytochromoxidase in the tissues of old rats.
mesh_terms: D000136:Acid-Base Equilibrium / Q000187:drug effects; D000284:Administration, Oral; D000375:Aging / Q000187:drug effects*; D000818:Animals; D001646:Bile / Q000187:drug effects; D004231:Diuresis / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation / Q000187:drug effects; D005260:Female; D005971:Glutamates / Q000494:pharmacology*; D007424:Intracellular Fluid / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D011189:Potassium Chloride / Q000494:pharmacology; D051381:Rats; D013997:Time Factors; D014882:Water-Electrolyte Balance / Q000187:drug effects
chemical_list: D005971:Glutamates; D011189:Potassium Chloride
vernacular_title: Izuchenie farmakologicheskoĭ aktivnosti kaliia glutaminata v éksperimente na molodykh i starykh zhivotnykh.