Short-term tissue culture of human breast cancer: presence of estrogen receptors and 17 beta-estradiol stimulation of RNA synthesis.
The stimulation of RNA synthesis induced by estradiol has been studied on 60 breast cancers in short-term cultures. In the same tumors the estrogen receptor (ER) assay was carried out. In 35% of the cases studied the stimulating effect by estradiol in vitro was observed. The frequency of response to in vitro hormone treatment was higher (42%) in ER+ cancers and lower (25%) in ER- cancers. The specificity of the in vitro test was assessed by the use of tamoxifen.
D001943:Breast Neoplasms / Q000378:metabolism* / Q000628:therapy; D004702:Endocrine Glands / Q000187:drug effects; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D009376:Neoplasms, Hormone-Dependent / Q000378:metabolism* / Q000628:therapy; D012334:RNA, Neoplasm / Q000096:biosynthesis*; D011960:Receptors, Estrogen / Q000187:drug effects*; D013629:Tamoxifen / Q000494:pharmacology
D012334:RNA, Neoplasm; D011960:Receptors, Estrogen; D013629:Tamoxifen; D004958:Estradiol