title: Cell proliferation in the rat pituitary gland: a mechanism of control in prolactin cells.
abstract: We investigated the relationship between prolactin content and DNA replication in the anterior pituitary gland. Thymidine incorporation in pregnant rats is significantly lower than in virgin controls. This is accompanied by a decreased activity of DNA polymerase. Sulpiride administration to pregnant rats enhances thymidine incorporation to levels similar to virgin controls. The results indicate a negative feedback between prolactin content and DNA synthesis in the rat anterior pituitary gland.
mesh_terms: D000818:Animals; D002455:Cell Division; D004247:DNA / Q000096:biosynthesis; D004261:DNA Replication; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism; D004720:Endonucleases / Q000378:metabolism; D005260:Female; D010903:Pituitary Gland, Anterior / Q000166:cytology* / Q000378:metabolism; D011247:Pregnancy; D011388:Prolactin / Q000378:metabolism / Q000502:physiology*; D051381:Rats; D013937:Thymidine Kinase / Q000378:metabolism
chemical_list: D011388:Prolactin; D004247:DNA; D013937:Thymidine Kinase; D004259:DNA-Directed DNA Polymerase; D004720:Endonucleases