title: Antianaphylactic agents. 1. 2-(Acylamino)oxazoles.
abstract: The synthesis and biological properties of 35 2-(acylamino)oxazoles are described. The majority of the compounds inhibit the release of slow-reacting substance of anaphylaxis (SRS-A) in vitro from sensitized guinea pig chopped lung. In addition, several of the compounds inhibited the release of SRS-A from passively sensitized human chopped lung and protected guinea pigs from the effects of anaphylaxis in a modified Herxheimer test.
mesh_terms: D000707:Anaphylaxis / Q000188:drug therapy*; D000818:Animals; D001986:Bronchial Spasm / Q000276:immunology / Q000517:prevention & control; D002199:Capillary Permeability / Q000187:drug effects; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D066298:In Vitro Techniques; D008168:Lung / Q000187:drug effects / Q000276:immunology; D008297:Male; D010080:Oxazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D051381:Rats; D013189:SRS-A / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D010080:Oxazoles; D013189:SRS-A