[Hypoglycemic activity of aromatic sulfohydrazides and their derivatives].
Tests on rabbits revealed the aromatic sulfohydrazides and their derivatives to display hypoglycemic action. A number of compounds superior to butamide by their sugar-lowering action and of low toxicity were discovered. The relationship between the chemical structure of the study substances and their hypoglycemic action is discussed.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D004353:Drug Evaluation, Preclinical; D006834:Hydrazines / Q000494:pharmacology*; D007004:Hypoglycemic Agents; D008297:Male; D011817:Rabbits; D013450:Sulfones / Q000494:pharmacology*; D013997:Time Factors; D014044:Tolbutamide / Q000494:pharmacology
D001786:Blood Glucose; D006834:Hydrazines; D007004:Hypoglycemic Agents; D013450:Sulfones; D014044:Tolbutamide
Gipoglikemicheskaia aktivnost' aromaticheskikh sul'fogidrazidov i ikh proizvodnykh.