Inversion duplication of chromosome 6 with trisomic codominant expression of HLA antigens.
Trisomic codominant expression of the HLA antigens was observed in an infant with duplication of a part of 6p occurring as a result of crossing over within a paternally transmitted pericentric inversion. The HLA-A and B loci were linked absolutely with the inversion chromosome in a four generation pedigree.
D000328:Adult; D007446:Chromosome Inversion; D002906:Chromosomes, Human, 6-12 and X; D005260:Female; D005799:Genes, Dominant; D006680:HLA Antigens / Q000032:analysis / Q000235:genetics*; D006801:Humans; D007223:Infant; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D010375:Pedigree; D014314:Trisomy
D006680:HLA Antigens