title: Detoxification from heroin using self vs physician regulation of methadone dose.
abstract: Self-regulation of methadone dose during detoxification was compared to a fixed dose schedule. Self-regulators tended to maintain themselves on a stable methadone dose until forced to detoxify, but used less heroin and remained in treatment longer than the control group. The results suggest that a longer initial period of methadone stabilization may be useful in enabling addicts to detoxify successfully.
mesh_terms: D000328:Adult; D000553:Ambulatory Care; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005069:Evaluation Studies as Topic; D005260:Female; D006556:Heroin Dependence / Q000453:epidemiology / Q000534:rehabilitation*; D006801:Humans; D008297:Male; D008691:Methadone / Q000008:administration & dosage* / Q000627:therapeutic use; D010352:Patient Dropouts; D012057:Reinforcement, Verbal; D012646:Self Administration
chemical_list: D008691:Methadone