Metabolism of 2-amino-3-phosphonopropionic acid in rats.
The metabolism of 2-amino-3-phosphono-[2-(14)C]propionic acid or 2-amino-3-phosphono-[3-(14)C]propionic acid in rats was studied in vivo and in vitro. The radioactivity in expired CO2 from the [3-(14)C]-labelled compound indicated the cleavage of the carbon-phosphorus (C-P) bond. A small amount of the [2-(14)C]-labelled compound and the [3-(14C]-labelled compound was incorporated into 2-aminoethylphosphonic acid, and polar lipid of the liver and kidney contained the 2-aminoethylphosphonic acid. The 2-amino-3-phosphonopropionic acid was not detected at the lipid level. Incorporation of the [3-(14)C]-labelled compound into a variety of metabolites including 3-phosphonopyruvic acid and 2-phosphonoacetaldehyde suggests the transamination reaction as a decomposition mechanism of 2-amino-3-phosphonopropionic acid in mammals.
D000409:Alanine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000652:urine; D000596:Amino Acids / Q000378:metabolism; D000615:Aminoethylphosphonic Acid / Q000378:metabolism; D000818:Animals; D002245:Carbon Dioxide / Q000378:metabolism; D002952:Citric Acid Cycle; D006019:Glycolysis; D066298:In Vitro Techniques; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D009928:Organ Specificity; D009943:Organophosphorus Compounds / Q000378:metabolism* / Q000652:urine; D051381:Rats
D000596:Amino Acids; D009943:Organophosphorus Compounds; D002245:Carbon Dioxide; D000615:Aminoethylphosphonic Acid; D000409:Alanine