[The effect of unconjugated bile salts on the intestinal absorption of electrolytes and water in the proximal jejunum. Studies in conscious rats (author's transl)].
With an in vivo-perfusion-technique the influence of unconjugated bile salts (cholate, desoxycholate) on the net electrolyte and volume absorption is studied in the jejunum of conscious rats. The applied doses correspond to physiological concentrations in the intestine of rats. Control experiments were performed in the same animal. Cholate and desoxycholate diminish the net electrolyte and volume absorption resp. cause a net secretion. The effects are largely reversible. The extent of net volume absorption depends on the applied dose of each bile salt. The possible mode of action of unconjugated bile salts on the electrolyte and water absorption in the small intestine is discussed.
D000818:Animals; D001647:Bile Acids and Salts / Q000502:physiology*; D002793:Cholic Acids / Q000502:physiology; D003840:Deoxycholic Acid / Q000502:physiology; D005260:Female; D007408:Intestinal Absorption; D007583:Jejunum / Q000378:metabolism*; D051381:Rats; D014882:Water-Electrolyte Balance
D001647:Bile Acids and Salts; D002793:Cholic Acids; D003840:Deoxycholic Acid
Die Wirkung unkonjugierter Gallensäuren auf die Elektrolyt- und Wasserabsorption im proximalen Jejunum. Perfusionsversuche an der wachen Ratte.