title: Protection of pregnant mice with phospholipase C and with Arvin against foetal death induced by bacterial lipopolysaccharide.
abstract: Injection of bacterial lipopolysaccharide into pregnant mice resulted in fibrinogen accumulation, thrombosis and haemorrhage in the placental tissue and foetal death. Depletion of circulating fibrinogen by a thrombin-like enzyme from the venom of Malayan pit viper, Arvin, prevents foetal death. Foetal protection was also obtained by treating the mothers with a preparation of phospholipase C from Bacillus cereus known to inactivate tissue thromboplastin. It is suggested the lipopolysaccharide causes foetal death by inducing thrombosis as a consequence of activation of placental thromboplastin.
mesh_terms: D000721:Ancrod / Q000627:therapeutic use*; D000818:Animals; D005260:Female; D005313:Fetal Death / Q000209:etiology / Q000517:prevention & control*; D005340:Fibrinogen / Q000037:antagonists & inhibitors; D008070:Lipopolysaccharides / Q000633:toxicity; D051379:Mice; D010740:Phospholipases / Q000627:therapeutic use*; D010920:Placenta / Q000473:pathology; D011247:Pregnancy; D013927:Thrombosis / Q000139:chemically induced
chemical_list: D008070:Lipopolysaccharides; D005340:Fibrinogen; D010740:Phospholipases; D000721:Ancrod