Dimethylformamide and alcohol intolerance.
Facial flushing and other symptoms were reported by 19 of a group of 102 men who worked with dimethylformamide (DMF). Twenty-six of the 34 episodes occurred after the workers had consumed alcoholic drinks. The metabolite N-methylformamide (MF) was detected in the urine on 45 occasions, the highest recorded concentration being 77 microliter/litre. The highest recorded concentration of DMF in air was 200 ppm. The DMF-ethanol reaction is possibly attributable to the inhibition of acetaldehyde metabolism, probably by MF.
D000395:Air Pollutants, Occupational / Q000009:adverse effects / Q000032:analysis; D004126:Dimethylformamide / Q000009:adverse effects* / Q000032:analysis / Q000378:metabolism; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology*; D005145:Face / Q000098:blood supply; D005559:Formamides / Q000652:urine; D006801:Humans; D008297:Male; D013997:Time Factors; D014664:Vasodilation / Q000187:drug effects
D000395:Air Pollutants, Occupational; D005559:Formamides; D000431:Ethanol; D004126:Dimethylformamide