[Pharmacokinetics of lidocaine after intramuscular injection in patients with acute myocardial infarction (author's transl)].
The kinetics of lidocaine after i.m. injection (M. deltoideus) of 300 mg were studied in patients with acute myocardial infarction in the course of 4 hrs.; another patient received this i.m. dose after being pretreated with 100 mg lidocaine i.v. The antiarrhythmically effective threshold concentration in plasma (1.5 mg/l) was reached after an average time of 5.5 min by 9 out of 10 patients. The mean value of maximum concentration after 30 min was 3.6 mg/l in 10 patients and the mean duration for exceeding the threshold (1.5 mg/l) was about 2 hrs. The elimination half-life for lidocaine valued 1.77 hrs. The toxic threshold concentration of 6 mg/l was exceeded for a short time by 3 patients without any side effects; in three other patients suffering from side-effects no relation to high plasma levels of lidocaine was observed.
D000208:Acute Disease; D001145:Arrhythmias, Cardiac / Q000188:drug therapy; D006207:Half-Life; D006801:Humans; D007273:Injections, Intramuscular; D008012:Lidocaine / Q000008:administration & dosage / Q000009:adverse effects / Q000097:blood / Q000378:metabolism* / Q000627:therapeutic use*; D009203:Myocardial Infarction / Q000188:drug therapy
D008012:Lidocaine
Pharmakokinetik von Lidocain nach intramuskulärer Injektion bei Patienten mit akutem Myokardinfarkt.