Improved delivery of methoxsalen.
Significant improvement in the effective bioavailability of methoxsalen was achieved when it was administered to rats and dogs in a solution as compared to a suspension. Much earlier and higher peak levels were observed for the solution in both animals. The possible impact of these observations on current use of this agent for psoriasis treatment is discussed.
D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D002214:Capsules; D002851:Chromatography, High Pressure Liquid; D004285:Dogs; D007275:Injections, Intravenous; D008297:Male; D008730:Methoxsalen / Q000008:administration & dosage* / Q000097:blood; D008954:Models, Biological; D051381:Rats; D012996:Solutions; D013535:Suspensions
D002214:Capsules; D012996:Solutions; D013535:Suspensions; D008730:Methoxsalen