title: Localization of 99mTc-methylene diphosphonate in skin lesions of pseudoxanthoma elasticum.
abstract: Increased uptake of 99mTc-methylene diphosphonate (MDP) is demonstrated in a patient with pseudoxanthoma elasticum (PXE) at the affected site. PXE is a hereditary disease with variable expression. Calification of dermal elastic fibers is a characteristic feature of affected skin. Recently, apatite crystals were identified in the affected skin of the patients with PXE. The mechanism of uptake of 99mTc-MDP is probably related to chemisorption of the tracer onto hydroxyapatite crystals in the affected dermis.
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D011561:Pseudoxanthoma Elasticum / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D012867:Skin / Q000000981:diagnostic imaging; D013667:Technetium
chemical_list: D013667:Technetium