Comparative dilator effect of verapamil and sodium nitroprusside in forearm arterial bed and dorsal hand veins in man: functional differences between vascular smooth muscle in arterioles and veins.
Verapamil and sodium nitroprusside induce a dose dependent dilatation in the forearm arterial bed and preconstricted dorsal hand vein in man. Verapamil is about twenty times more effective in dilating arterioles than veins; sodium nitroprusside is about ten times more effective in veins than arterioles. These differences can be related to functional differences between the two types of vessel.
D000328:Adult; D001158:Arteries / Q000187:drug effects*; D001160:Arterioles / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005292:Ferricyanides / Q000494:pharmacology*; D005542:Forearm / Q000098:blood supply; D006225:Hand / Q000098:blood supply; D006801:Humans; D008297:Male; D008875:Middle Aged; D009130:Muscle, Smooth / Q000187:drug effects; D009599:Nitroprusside / Q000494:pharmacology*; D014664:Vasodilation / Q000187:drug effects*; D014680:Veins / Q000187:drug effects*; D014700:Verapamil / Q000494:pharmacology*
D005292:Ferricyanides; D009599:Nitroprusside; D014700:Verapamil