title: Familial (genetic) subtypes of pure depressive disease.
abstract: The author reviewed data from five studies and found that depressed patients with a history of depression in a parent or child have more sibships containing depression than depressed patients without this family history. Thus, there is a clustering of depressions in certain families. Sporadic pure depressive disease (PDD), where no depressive illness exists in a first-degree family member of a depressed proband, is associated with a later age of onset than familial PDD, where depressive illness does exist in a first-degree relationship. The possibility exists that familial PDD and sporadic PDD are autonomous illnesses. The presence of a family history of depression may be predictive to some extent of a good response to adequate tricyclic medication or ECT.
mesh_terms: D000328:Adult; D000367:Age Factors; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000235:genetics; D003863:Depression / Q000235:genetics* / Q000628:therapy; D003865:Major Depressive Disorder / Q000235:genetics; D004565:Electroconvulsive Therapy; D005260:Female; D006801:Humans; D008297:Male; D010290:Parents; D012559:Schizophrenia / Q000235:genetics
chemical_list: D000929:Antidepressive Agents, Tricyclic