[Activity of Krebs cycle oxidative enzymes in the brain in hypothermia].
Cooling of rats down to the rectal temperature of 33--35 degrees without the use of narcotic and neuroplegic drugs did not cause distinct alterations in activity of the oxidative enzymes of tricarboxylic acid cycle--isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase, malate-, succinate- and pyruvate dehydrogenases in brain tissue. At the same time, inhibition of the activity of these dehydrogenases occurred in profound hypothermia (cooling to 19--20 degrees). In this case the activity of succinate dehydrogenase was decreased less distinctly as compared with the activity of NAD-dependent dehydrogenases. Succinic acid appears to be an especially important substrate for oxidation in brain of the chilled rats.
D000818:Animals; D001831:Body Temperature; D001921:Brain / Q000201:enzymology*; D002952:Citric Acid Cycle; D004789:Enzyme Activation; D007035:Hypothermia / Q000201:enzymology*; D007521:Isocitrate Dehydrogenase / Q000378:metabolism; D007655:Ketoglutarate Dehydrogenase Complex / Q000378:metabolism; D008291:Malate Dehydrogenase / Q000378:metabolism; D010088:Oxidoreductases / Q000378:metabolism*; D011768:Pyruvate Dehydrogenase Complex / Q000378:metabolism; D051381:Rats; D013385:Succinate Dehydrogenase / Q000378:metabolism
D011768:Pyruvate Dehydrogenase Complex; D010088:Oxidoreductases; D008291:Malate Dehydrogenase; D007521:Isocitrate Dehydrogenase; D007655:Ketoglutarate Dehydrogenase Complex; D013385:Succinate Dehydrogenase
Aktivnost' okislitel'nykh fermentov tsikla Krebsa v golovnom mozge pri gipotermii.