title: [Action of cyclophosphane on the formation of hemagglutinins and of nonspecific immunoglobulins in a microbe-free state].
abstract: A total of 39 germ-free and 28 conventional germ-free Fisher rats were used to study cyclophosphamide-induced specific (hemagglutinins) and nonspecific (IgG2) immunosuppression. Most pronounced effect of the drug was observed in germ-free animals. 180 mg/kg of cyclophosphamide completely suppressed hemagglutinin formation for at least 8 weeks.
mesh_terms: D000373:Agglutinins / Q000096:biosynthesis*; D000818:Animals; D001798:Blood Proteins / Q000032:analysis; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000276:immunology* / Q000633:toxicity; D004306:Dose-Response Relationship, Immunologic; D005856:Germ-Free Life / Q000187:drug effects*; D006388:Hemagglutinins / Q000096:biosynthesis*; D007074:Immunoglobulin G / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D012709:Serum Albumin / Q000032:analysis
chemical_list: D000373:Agglutinins; D001798:Blood Proteins; D006388:Hemagglutinins; D007074:Immunoglobulin G; D012709:Serum Albumin; D003520:Cyclophosphamide
vernacular_title: Deĭstvie tsiklofosfana na obrazovanie gemaggliutininov i nespetsificheskikh immunoglobulinov pri stause bezmikrobnosti.