Malignant melanoma of choroid in a case of nevus of Ota.
A white woman with unilateral nevus of Ota presented with visual loss and an intraocular mass resembling a choroidal melanoma. Indirect ophthalmoscopy, fluorescein angiography, ultrasonography, and radioactive phosphorus uptake corroborated the clinical impression and surgery was advised. Following enucleation, the specimen was examined with light microscopy, which revealed a mixed cell type malignant melanoma of the choroid. Electron microscopy disclosed the presence of premelanosomes in the episclera, indicating that the episcleral pigmentation is a result of melanocytic evolution. This paper represents the tenth report in the literature of choroidal melanoma occurring in a patient with nevus of Ota, and the first electron-microscopic study of an eye with this association of lesions.
D000368:Aged; D002830:Choroid Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D005123:Eye / Q000000981:diagnostic imaging / Q000648:ultrastructure; D005260:Female; D006801:Humans; D008545:Melanoma / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D009508:Nevus, Pigmented / Q000150:complications*; D013508:Ophthalmologic Surgical Procedures; D011877:Radionuclide Imaging; D012878:Skin Neoplasms / Q000150:complications*; D014463:Ultrasonography