Incidence, etiology, and outcome of pulseless idioventricular rhythm treated with dexamethasone during advanced CPR.
The cardiac resuscitation records of 458 patients who received advanced cardiac life support at Detroit General Hospital during the last two years were reviewed to identify patients who had pulseless idioventricular rhythm (PIVR) recognized and treated with dexamethasone. Twenty-five cases were identified. The initial successful resuscitation rate of 52% in these patients contrasts sharply with other published data indicating 100% failure with the use of conventional chronotropic drugs. The most common etiology of cardiac arrest in our patients who display PIVR during resuscitation is hypoperfusion shock. Dexamethasone may counteract the lethal arrhythmia by causing the release of aditional adenosine triphosphate into the cytoplasm from the mitochondria.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000328:Adult; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000150:complications / Q000188:drug therapy*; D003907:Dexamethasone / Q000494:pharmacology / Q000627:therapeutic use*; D004285:Dogs; D005260:Female; D006323:Heart Arrest / Q000150:complications / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008929:Mitochondria, Heart / Q000378:metabolism; D009201:Myocardial Depressant Factor / Q000097:blood; D010101:Oxygen Consumption; D012151:Resuscitation; D012770:Shock, Cardiogenic / Q000097:blood
D009201:Myocardial Depressant Factor; D003907:Dexamethasone; D000255:Adenosine Triphosphate