[Diaplacental transfer of verapamil in guinea pigs (author's transl)].
Verapamil (1--50 mcg/kg/min) was given to guinea pigs by intravenous infusion for 30 minutes. The average clinical dosage amounts to 1 (0,5--2) mcg/kg/min. At doses of 1--10 mcg/kg/min we could not find pharmacologically effective concentrations of verapamil in plasma, although concentrations in mother rose corresponding to administered doses. Only at dosage 50 mcg/kg/min we found comparatively to the mother low, but clearly measurable concentrations also in fetal plasma. That means: Verapamil, administered to guinea pigs--hemomonochorial placentation like man--in dosage, given for tocolysis does not appear in fetal plasma with pharmacologically effective concentration.
D000818:Animals; D005260:Female; D006168:Guinea Pigs; D007261:Infusions, Intra-Arterial; D008431:Maternal-Fetal Exchange; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D014700:Verapamil / Q000008:administration & dosage / Q000378:metabolism*
D014700:Verapamil
Untersuchungen zur Plazentapassage von Verapamil beim Meerschweinchen.