[Effect of pesticides on cholinesterase activity in the nervous elements of the heart in pregnant animals and fetuses].
Cholinestarase activity in the cardiac neural elements of pregnant animals and in their offspring was studied under the effect of chlororganic pesticide -- polychlorcamphen and phosphororganic pesticide -- valexone. The substances in question were demonstrated to produce variously pronounced unidirected changes in cholinesterase activity in neural structures that testifies to interconnection and dependence of the changes in the system mother -- fetus. The alterations observed in nonsynaptic (trophic) cholinesterase make it possible to speak about the disorder of cholinergic innervation and about the importance of acetilcholinesterase trophic function as a regulator of cellular processes, an inhibitory index of differentiation during embryogenesis.
D000818:Animals; D002800:Cholinesterase Inhibitors; D005260:Female; D005318:Fetal Heart / Q000294:innervation; D006321:Heart / Q000294:innervation*; D007306:Insecticides / Q000494:pharmacology*; D008431:Maternal-Fetal Exchange; D009474:Neurons / Q000201:enzymology; D009946:Organothiophosphorus Compounds; D011247:Pregnancy; D051381:Rats; D014112:Toxaphene / Q000494:pharmacology*
D002800:Cholinesterase Inhibitors; D007306:Insecticides; D009946:Organothiophosphorus Compounds; C003135:phoxim; D014112:Toxaphene
Deĭstvie pestitsidov na aktivnost' kholinésterazy v nervnykh élementakh serdtsa beremennykh zhivotnykh i poldov.