Reduction of the renal toxicity of cis-dichlorodiammineplatinum(II) by probenecid.
Probenecid, when administered sc to F344 rats 1 hour prior to an iv LD50 dose of cis-dichlorodiammineplatinum(II) (CDPP), reduced significantly the peak BUN and serum creatinine levels which occurred 4 days following CDDP. Renal histopathology was similarly reduced by probenecid pretreatment. In BDF, mice, the LD50 value of CDDP administered ip without probenecid pretreatment was 17 mg/kg; the LD50 dose with probenecid was increased to greater than 19 mg/kg. Probenecid pretreatment did not influence the therapeutic response to CDDP when the letter was administered to BDF mice bearing L1210 leukemia.
D000818:Animals; D001806:Blood Urea Nitrogen; D002509:Cephaloridine / Q000494:pharmacology; D002945:Cisplatin / Q000009:adverse effects*; D003404:Creatinine / Q000097:blood; D003864:Depression, Chemical; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D011339:Probenecid / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344; D010130:p-Aminohippuric Acid / Q000378:metabolism
D003404:Creatinine; D002509:Cephaloridine; D011339:Probenecid; D002945:Cisplatin; D010130:p-Aminohippuric Acid