[The biochemical mechanism of action of proquazone with special reference to the metabolism of connective tissue (biochemical studies for the determination of antiinflammatory effectiveness)].
A method is proposed to determine the specific radioactivity of proteokeratan sulfate and proteochondroitin sulfate after incorporation of 35SO4 and 3H-glucosamine. Proquazone inhibits the incorporation of 35SO4 in proteochondroitin sulfate and also in proteokeratan sulfate. Also the incorporation of 3H-glucosamine in proteokeratan sulfate and proteochondroitin sulfate is inhibited. A mechanism is proposed in which Proquazon inhibits the core protein synthesis of proteoglycans and the secondary biosynthesis of the glycosaminoglycan chains. In our opinion the action of an anti-inflammatory drug is based on the inhibition of the proteoglycan synthesis in the anabolic phase of the inflammation.
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D000893:Anti-Inflammatory Agents; D002417:Cattle; D011508:Chondroitin Sulfate Proteoglycans / Q000378:metabolism; D003238:Connective Tissue / Q000378:metabolism*; D003315:Cornea / Q000187:drug effects*; D005688:Galactosamine / Q000032:analysis; D005944:Glucosamine / Q000032:analysis; D006025:Glycosaminoglycans / Q000032:analysis; D007632:Keratan Sulfate / Q000378:metabolism; D011799:Quinazolines / Q000494:pharmacology*
D000596:Amino Acids; D000893:Anti-Inflammatory Agents; D011508:Chondroitin Sulfate Proteoglycans; D006025:Glycosaminoglycans; D011799:Quinazolines; C011385:proquazone; D005688:Galactosamine; D007632:Keratan Sulfate; D005944:Glucosamine
Zum biochemischen Wirkungsmechanismus von Proquazon unter besonderer Berücksichtigung des Bindegewebsstoffwechsels (Biochemische Untersuchungen zur Prüfung der antiphlogistischen Wirksamkeit).