The effects of the polyene antibiotic mepartricin on polymorphonuclear leucocyte function: an in-vitro study.
Mepartricin, a polyene antibiotic with candidacidal and trichomonicidal activity, was found to be without toxic effects for human polymorphonuclear leucocytes; the drug seems to be unable to enter the human cells. Some synergism between the antifungal activities of mepartricin and of human leucocytes is seen if Candida cells are pre-incubated with sub-lethal concentrations of the drug.
D002175:Candida / Q000187:drug effects / Q000502:physiology; D002478:Cells, Cultured; D005947:Glucose / Q000378:metabolism; D006801:Humans; D008613:Mepartricin / Q000494:pharmacology*; D009504:Neutrophils / Q000187:drug effects* / Q000502:physiology; D009580:Nitroblue Tetrazolium; D010084:Oxidation-Reduction; D010587:Phagocytosis / Q000187:drug effects; D011090:Polyenes / Q000494:pharmacology*
D011090:Polyenes; D008613:Mepartricin; D009580:Nitroblue Tetrazolium; D005947:Glucose