title: Effects of systemic hypothermia on myocardial metabolism and coronary blood flow in the fibrillating heart.
abstract: Ventricular fibrillation during normothermic cardiopulmonary bypass is deleterious to the myocardium. This study was undertaken to determine if moderate systemic hypothermia would protect the myocardium during ventricular fibrillation. Fourteen mongrel dogs were subjected to 1 hour, 15 minutes of total cardiopulmonary bypass. Ventricular fibrillation was induced by a continuous electrical alternating current applied at the beginning of bypass and lasting for 1 hour. Six animals were maintained at normothermia (Group I), and eight were cooled to 30 degrees C. for 1 hour (Group II). The hypothermic group (Group II) demonstrated lower myocardial oxygen consumption and metabolism, decreased coronary blood flow, and less myocardial lactate production during ventricular fibrillation than did Group I. It is concluded that hypothermia does offer some protection, although not complete, against the deleterious effects of ventricular fibrillation described previously.
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001794:Blood Pressure; D002302:Cardiac Output; D009202:Cardiomyopathies / Q000209:etiology* / Q000517:prevention & control; D003326:Coronary Circulation; D004285:Dogs; D005069:Evaluation Studies as Topic; D007036:Hypothermia, Induced; D007773:Lactates / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D010101:Oxygen Consumption; D014693:Ventricular Fibrillation / Q000378:metabolism / Q000503:physiopathology*
chemical_list: D007773:Lactates; D000255:Adenosine Triphosphate