The interaction of aquated cis-[(NH3)2Pt(II)]with nucleic acid constituents. II. Modified nucleosides.
The binding interaction of aquated cis-(NH3)2Pt(II) with 1-methylguanosine (1-MeGuo), 7-methylguanosine (7-MeGuo), 1-methyladenosine (1-MeAdo+) and protonated adenosine has been studied using UV difference spectroscopy. The magnitude of the binding constants for the 1 : 1 interaction of cis-(NH3)2Pt(II) with 1-MeDuo and 1-MeAdo are log K = 3.5 and 3.7, respectively. These data are presented and compared to other cis-(NH3)2Pt(II)-nucleoside interactions.
D000241:Adenosine / Q000031:analogs & derivatives; D001665:Binding Sites; D002945:Cisplatin / Q000378:metabolism*; D004247:DNA / Q000032:analysis*; D006151:Guanosine / Q000031:analogs & derivatives; D009705:Nucleosides / Q000378:metabolism*; D013056:Spectrophotometry, Ultraviolet
D009705:Nucleosides; D006151:Guanosine; C020770:1-methylguanosine; C016578:7-methylguanosine; D004247:DNA; D000241:Adenosine; D002945:Cisplatin