title: Duplication of a spontaneously active neuron in Aplysia: electrical coupling and effects of a phosphodiesterase inhibitor.
abstract: An abdominal ganglion from an Aplysia californica is described, in which cell R15 has anomalously duplicated. The two cells exhibited a high degree of electrical coupling, assuring functional synchrony of output in the cells, which are characterized by a complex firing pattern. Exposure of this ganglion to the phosphodiesterase inhibitor IBMX caused a more altered firing rhythm in one of the cells, as well as an enhanced inhibitory component associated with the coupling potentials between cells, resulting in a loss of synchrony between the two cells.
mesh_terms: D000818:Animals; D001048:Aplysia / Q000502:physiology*; D004594:Electrophysiology; D005724:Ganglia / Q000187:drug effects / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology*; D014970:Xanthines / Q000494:pharmacology*
chemical_list: D010726:Phosphodiesterase Inhibitors; D014970:Xanthines