Delirium associated with combined fluphenazine-clonidine therapy.
The authors report a case of acute organic brain syndrome in a patient being treated with clonidine and fluphenazine that cleared when clonidine was discontinued. Theoretical considerations of dopamine-norephinephrine interactions are discussed in the context of the drug-drug interaction.
D000328:Adult; D003000:Clonidine / Q000009:adverse effects* / Q000627:therapeutic use; D003693:Delirium / Q000139:chemically induced*; D004359:Drug Therapy, Combination; D005476:Fluphenazine / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008297:Male; D011618:Psychotic Disorders / Q000188:drug therapy
D003000:Clonidine; D005476:Fluphenazine