title: Blood glucose changes during neurosurgery.
abstract: Blood glucose levels were studied prospectively in 40 patients undergoing elective major craniotomy. A significant (p less than 0.01) hyperglycaemic response was noted after scalp infiltration with adrenaline and incision (0.5 mmol/l) and with continued surgery (0.9 mmol/l). Patients aged 50 years and under showed a significantly greater rise with adrenaline and incision than older patients (0.8 compared with 0.4 mmol/l p less than 0.01). Preoperative high dose steroid therapy did not modify the response. Blood glucose changes were unrelated to sex, obesity, a family history of diabetes, the duration of starvation, intraoperative body temperature, anaesthetic technique, induced hypotension or blood loss.
mesh_terms: D000328:Adult; D000368:Aged; D000758:Anesthesia; D001786:Blood Glucose / Q000378:metabolism*; D003399:Craniotomy; D004837:Epinephrine / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011229:Preanesthetic Medication; D011446:Prospective Studies; D012535:Scalp; D013256:Steroids / Q000008:administration & dosage
chemical_list: D001786:Blood Glucose; D013256:Steroids; D004837:Epinephrine