title: Pigmentoarchitectonic pathology of the isocortex in juvenile neuronal ceroid-lipofuscinosis: axonal enlargements in layer IIIab and cell loss in layer V.
abstract: Pigment preparations of 800 micrometer thickness and Golgi studies of the isocortex in juvenile neuronal ceroid-lipofuscinosis, morphologically proven by electron microscopy, revealed: 1. giant axonal dilatations of IIIab-pyramids. These expansions exceeded by far those found in pyramidal cell axons of other isocortical layers. 2. severe numerical reduction of neurons in the ganglionic layer.
mesh_terms: D000293:Adolescent; D001369:Axons / Q000648:ultrastructure; D002540:Cerebral Cortex / Q000473:pathology / Q000648:ultrastructure; D002566:Ceroid; D006801:Humans; D008064:Lipidoses / Q000473:pathology*; D008062:Lipofuscin; D008297:Male; D009474:Neurons / Q000648:ultrastructure
chemical_list: D002566:Ceroid; D008062:Lipofuscin