Trans-4-hydroxy-3-methoxycinnamic acid (ferulic acid) inhibits the effect of androgens on the rat prostate.
Trans-4-hydroxy-3-methoxycinnamic acid (ferulic acid, FA) antagonized the effect of exogenous androgens on the ventral prostate (VP) in castrated rats as well as the effect of endogenous androgens in intact rats. FA, however, had no effect on the seminal vesicles (SV) and levator ani muscle (LAM), nor oestrogenic effect in female rats and mice. FA did not antagonize the receptor binding of testosterone nor inhibit the conversion of testosterone into 5 alpha-dihydrotestosterone (DHT).
D000596:Amino Acids / Q000378:metabolism; D000726:Androgen Antagonists; D000818:Animals; D002369:Castration; D002934:Cinnamates / Q000494:pharmacology*; D003373:Coumaric Acids / Q000494:pharmacology*; D005260:Female; D008297:Male; D009132:Muscles / Q000187:drug effects / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D011467:Prostate / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D012669:Seminal Vesicles / Q000187:drug effects / Q000378:metabolism; D013739:Testosterone / Q000378:metabolism; D014599:Uterus / Q000187:drug effects
D000596:Amino Acids; D000726:Androgen Antagonists; D002934:Cinnamates; D003373:Coumaric Acids; D013739:Testosterone