The relationship of Schwann cell migration in vitro to injury, using normal, Wobbler, and dystrophic mice.
A quantitative in vitro study of the cellular outgrowth from mouse sciatic nerve explants has been carried out using both normal untreated nerves and nerves taken at various times after the in vivo application of trauma. The results obtained have been compared with the results for outgrowth from sciatic nerve of two neurological mutants: 'the Wobbler mouse' and the 'ReJ 129 Dystrophic mouse'. It has been shown that the in vitro response to peripheral injury does reflect the activity known to occur in vivo. Outgrowth from explants of mutant mouse nerves, although differing from normal has been found to be less profuse than that occurring after mechanical nerve injury.
D000818:Animals; D002452:Cell Count; D002465:Cell Movement; D002478:Cells, Cultured; D005347:Fibroblasts / Q000166:cytology; D051379:Mice; D008818:Mice, Neurologic Mutants; D008938:Mitosis; D009137:Muscular Dystrophy, Animal / Q000503:physiopathology*; D009409:Nerve Crush; D009416:Nerve Regeneration; D012583:Schwann Cells / Q000166:cytology*; D012584:Sciatic Nerve / Q000166:cytology* / Q000293:injuries