Brain distribution of propranolol in the rat.
The distribution and kinetics of D,L-propranolol in rat brain were examined after an intravenous injection of the drug. Measurements in brain areas and blood were performed by means of a sensitive and specific gas liquid chromatographic method. The disappearance rate in cortical areas paralleled that in blood. However D,L-propranolol decreased at a slower rate in hypothalamic and medullary nuclei. Since propranolol is believed to have central hypotensive effects, its retention by certain central nuclei involved in blood pressure regulation is of interest.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D006207:Half-Life; D007700:Kinetics; D008297:Male; D011433:Propranolol / Q000097:blood / Q000378:metabolism*; D051381:Rats
D011433:Propranolol