Effect of colicin E3 on leukemia cells P388 in vitro.
Proliferation of murine leukemia cells P388 is stimulated by less than 1.0 mg/ml colicin E3, while being inhibited by higher concentrations. By 1.6 mg/ml colicin E3, uptake of thymidine into cold TCA-precipitable fraction is decreased by 59% during 24 h, uptake of uridine by 29%.
D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D003087:Colicins / Q000494:pharmacology*; D004273:DNA, Neoplasm / Q000096:biosynthesis*; D004305:Dose-Response Relationship, Drug; D051379:Mice; D012334:RNA, Neoplasm / Q000096:biosynthesis*; D013936:Thymidine / Q000378:metabolism; D014529:Uridine / Q000378:metabolism
D003087:Colicins; D004273:DNA, Neoplasm; D012334:RNA, Neoplasm; D013936:Thymidine; D014529:Uridine