Terpenoid biotransformation in mammals. II: Biotransformation of dl-camphene in rabbits.
The biotransformation of dl-camphene in rabbits was investigated. Four neutral metabolites, 6-exo-hydroxycamphene, 10-hydroxycamphene, and diastereoisomers of camphene-2,10-glycol, were identified and two alcohols, 7-hydroxycamphene and 3-hydroxytricyclene, were estimated by IR, UV, NMR, and mass spectra and chemical degradations. The formation of these compounds can be explained through a homoallylic oxidation or an epoxide formation.
D000818:Animals; D001711:Biotransformation; D001892:Camphanes / Q000378:metabolism* / Q000652:urine; D008297:Male; D011817:Rabbits
D001892:Camphanes