title: [Clinical studies on apalcillin treatment for bile duct infections (author's transl)].
abstract: The clinical effects of apalcillin (APPC) treatment for 7 patients with bile duct infections were investigated and the following results were obtained. 1) Clinical effectiveness: Of 7 patients treated with APPC, the results were good in 5 cases, fair in 1 case and poor in 1 case. 2) Absorption and excretion of APPC: One g of APPC was administered with one shot intravenously to 4 patients of which 2 were malignant tumor cases and the remaining 2 non tumor cases. A peak of APPC level in serum and bile was 79 microgram/ml and 140 microgram/ml respectively in malignant tumor cases and 96 microgram/ml and 180 microgram/ml respectively in non tumor cases. 3) Side effects of APPC: No significant side effects were observed in 7 patients treated with APPC, except abnormal elevation of S-GOT and S-GPT levels occurred transiently in 2 of 7 cases.
mesh_terms: D000328:Adult; D000368:Aged; D000667:Ampicillin / Q000031:analogs & derivatives* / Q000378:metabolism / Q000627:therapeutic use; D001424:Bacterial Infections / Q000188:drug therapy*; D001660:Biliary Tract Diseases / Q000188:drug therapy*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D000667:Ampicillin