[Effect of alpha-tocopherol acetate and sodium selenite on the change in ATP content and the RNA synthesis rate in the ischemic myocardium].
The effect of preliminary administration of alpha-tocopherol acetate (1 mg/kg) and sodium selenite (1 mg/kg) on RNA synthesis rate and changes in the macroergic content in ischemic myocardium was studied. It was shown to be conducive to ATP level maintenance after 30- and 60-minute heart ischemia. A statistically significant accumulation of RNA by the myocardium following I-hour ischemia as well as this polynucleotide synthesis activation were recorded. Preservation of the energetic resources by the cell along with RNA metabolism returning to normal contributes to inhibiting the emergence of irreversible cell damage and increases regenerative potentialities of the myocardium.
D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D003327:Coronary Disease / Q000188:drug therapy* / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D004734:Energy Metabolism / Q000187:drug effects; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D012643:Selenium / Q000627:therapeutic use*; D013997:Time Factors; D014810:Vitamin E / Q000627:therapeutic use*
D014810:Vitamin E; D012313:RNA; D000255:Adenosine Triphosphate; D012643:Selenium
Vliianie al'fa-tokoferolatsetata i selenita natriia na izmenenie soderzhaniia ATF i skorosti sinteza RNK v ishemizirovannom miokarde.