Antibody-dependent and spontaneous lympholysis in urologic cancer patients.
To evaluate cytotoxic function mediated by killer lymphocytes and macrophages in urological cancer patients, we examined antibody-dependent and spontaneous lympholysis of chicken erythrocyte target cells, which is mediated by macrophages. Our results demonstrate a discordance between cytotoxic mechanisms in cancer patients, killer-cell function being impaired whilst macrophage-mediated cytotoxicity was increased.
D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity; D006801:Humans; D007694:Killer Cells, Natural / Q000502:physiology; D007958:Leukocyte Count; D008214:Lymphocytes / Q000502:physiology*; D008264:Macrophages / Q000276:immunology; D010587:Phagocytosis; D014571:Urologic Neoplasms / Q000276:immunology*