Progressive hypogammaglobulinaemia in a child born to a mother with Hodgkin's disease.
A young woman developed Hodgkin's disease (nodular sclerosis) in pregnancy and gave birth to a boy who developed common variable immunodeficiency. Initially there was normal IgG with low IgA and IgM, and antibody deficiency. IgG levels fell progressively over 4 years. Cellular immunity was normal. We suggest that this is a further family with immune deficiency presenting with common variable immunodeficiency and lymphoid malignancy.
D000328:Adult; D000361:Agammaglobulinemia / Q000235:genetics*; D002648:Child; D005260:Female; D006689:Hodgkin Disease / Q000235:genetics*; D006801:Humans; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications