Plasma levels of tocopherol in sickle cell anemia subjects.
Plasma tocopherol levels of less than 0.8 microgram/g lipid were considered indicative of a vitamin E-deficient status. Based on this criterion, 10 out of 13 sickle cell anemia patients who were not in crisis, were considered deficient in vitamin E as compared to none of 24 normal control subjects. Sickle cell anemia patients treated with 150 IU vitamin E (dl-alpha-tocopheryl acetate) three times a day for 1 to 2 months had plasma tocopherol levels similar to control subjects. The possible role of vitamin E status on the manifestation of sickle cell anemia is discussed. The present study confirmed the vitamin E-deficient status of subjects with beta-thalassemia. Six of seven patients with beta-thalassemia had tocopherol levels of less than 0.8 mg/g lipid.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000755:Anemia, Sickle Cell / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D013789:Thalassemia / Q000097:blood / Q000150:complications; D014810:Vitamin E / Q000097:blood* / Q000627:therapeutic use; D014811:Vitamin E Deficiency / Q000150:complications
D008055:Lipids; D014810:Vitamin E