title: The secretory process in the pancreatic exocrine cell.
abstract: Recent findings that contribute to an understanding of the secretory process in the pancreatic exocrine cell are reviewed. These include (1) the separation, identification, and characterization of secreted proteins by two-dimensional gel electrophoresis, (2) the intracellular route and timetable of movement of secretory proteins from one intracellular compartment to another, (3) the mechanism by which presecretory proteins are thought to be transported across the lipid bilayer of the rough endoplasmic reticulum (the transport peptide hypothesis), and (4) the importance of accessory peptide domains that determine the ultimate location and site-specific function of exportable proteins.
mesh_terms: D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001692:Biological Transport; D004721:Endoplasmic Reticulum / Q000378:metabolism; D004792:Enzyme Precursors; D006168:Guinea Pigs; D008565:Membrane Proteins / Q000378:metabolism; D008861:Microsomes / Q000378:metabolism; D010179:Pancreas / Q000201:enzymology / Q000378:metabolism* / Q000648:ultrastructure; D010455:Peptides / Q000378:metabolism; D014176:Protein Biosynthesis; D011506:Proteins / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism
chemical_list: D000596:Amino Acids; D004792:Enzyme Precursors; D008565:Membrane Proteins; D010455:Peptides; D011506:Proteins; D012333:RNA, Messenger