Sugar derivatives and liver mitochondria. I. - Effect of methyl-3,5-di-O-benzyl-2-chloro-2-deoxy-D-arabinofuranoside.
Effect of fifteen sugar derivatives on oxygen uptake and oxidative phosphorylation by liver mitochondria were tested. Full details of the possible mechanism of action of methyl-3,5-di-O-benzyl-2-chloro-2-deoxy-D-arabinofuranoside (VI) was presented. This sugar derivative seems to act as inhibitor of the electron transport in the respiratory chain and as an uncoupler.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001089:Arabinose / Q000031:analogs & derivatives* / Q000494:pharmacology; D004140:Dinitrophenols / Q000494:pharmacology; D066298:In Vitro Techniques; D007656:Ketoglutaric Acids / Q000378:metabolism; D008759:Methylglycosides / Q000494:pharmacology*; D008929:Mitochondria, Heart / Q000187:drug effects / Q000378:metabolism; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism; D008933:Mitochondrial Swelling / Q000187:drug effects; D010084:Oxidation-Reduction / Q000187:drug effects; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D013386:Succinates / Q000378:metabolism
D004140:Dinitrophenols; D007656:Ketoglutaric Acids; D008759:Methylglycosides; D013386:Succinates; C019474:methyl-3,5-di-O-benzyl-2-chloro-2-deoxy-D-arabinofuranoside; D000255:Adenosine Triphosphate; D001089:Arabinose