title: Dysfunction of small airways following pulmonary injury due to nitrogen dioxide.
abstract: Serial physiologic studies were performed to characterize both the immediate and delayed effects of a single occupational exposure to nitrogen dioxide in a nonsmoker. During the initial acute stage of pulmonary edema, the abnormal static pressure-volume curve and decreased static compliance corresponded to a reduction in pulmonary volume. During the delayed acute stage, elastic recoil and properties of resistance to flow were normal, but dynamic compliance was reduced and dependent on respiratory frequency, and oxygen transport was abnormal during exercise, which is consistent with dysfunction of the small airways.
mesh_terms: D005540:Forced Expiratory Flow Rates; D005541:Forced Expiratory Volume; D006801:Humans; D008171:Lung Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009585:Nitrogen Dioxide / Q000506:poisoning*; D009784:Occupational Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D011654:Pulmonary Edema / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D012120:Respiration Disorders / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D014109:Total Lung Capacity; D014797:Vital Capacity
chemical_list: D009585:Nitrogen Dioxide