The detection of various nitrosamines in the hepatocyte primary culture/DNA repair test.
Evaluation of 6 carcinogenic nitrosamines in the hepatocyte primary culture/DNA repair test revealed that all were active. Three non-carcinogenic analogs were negative. This sensitivity to nitrosamines, together with considerations concerning the metabolic capability and end point of this assay, indicates that it will be a useful addition to screening batteries that include bacterial mutagenesis assays.
D000818:Animals; D002273:Carcinogens; D004260:DNA Repair / Q000187:drug effects*; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D009153:Mutagens; D009602:Nitrosamines / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D013936:Thymidine / Q000008:administration & dosage; D013997:Time Factors
D002273:Carcinogens; D009153:Mutagens; D009602:Nitrosamines; D013936:Thymidine