Drug entrapment for controlled release in radiation-polymerized beads.
The preparation of beads including polymer, vinyl monomer, and drug was carried out by low temperature, radiation-induced polymerization. Complete spherical particles were obtained when ethanol was the precipitation medium Polymers such as polymethyl methacrylate and polystyrene were dissolved in various glass-forming monomers, and the drug was dispersed in the mixture. The mixture was dropped into cold precipitation media. The formed monomeric particle was irradiated at low temperatures to produce polymerization. The drug release profiles from polymerized particles were changed by varying the glass-forming monomer and the precipitation medium.
D003692:Delayed-Action Preparations; D005720:Gamma Rays; D005898:Glass; D008863:Microspheres; D011108:Polymers / Q000528:radiation effects; D011189:Potassium Chloride
D003692:Delayed-Action Preparations; D011108:Polymers; D011189:Potassium Chloride