[Effect of carminomycin on the energy metabolism of the liver in rats].
The effect of carminomycin on the liver energetic metabolism was studied experimentally on rats in dynamics after its intraperitoneal administration in a single LD50 and the therapeutic doses for a treatment course. It was found that changes in the rat liver tissues on the part of the energetic metabolism occurred irrespective of the antibiotic dose and the administration multiplicity. Mainly they were of reversible nature: the balance of consumption and resynthesis of the phosphate macroergs was impaired, the glycolytic processes increased, shifts in the activity of the enzymes of the pentose phosphate pathway of oxydation were observed. The level of the above changes was more pronounced when carminomycin was administered in LD50. The adrenal system played an important role in the mechanism of the shifts noted.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D002360:Carubicin / Q000494:pharmacology*; D002395:Catecholamines / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004734:Energy Metabolism / Q000187:drug effects*; D006019:Glycolysis / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008112:Liver Glycogen / Q000378:metabolism; D051381:Rats; D013997:Time Factors
D000903:Antibiotics, Antineoplastic; D002395:Catecholamines; D008112:Liver Glycogen; D002360:Carubicin
Issledovanie vliianiia karminomitsina na énergetickeskiĭ metabolizm pecheni krys.