Immunological properties of synthetic human parathyroid hormone 53--84 fragment.
The immunological properties of a synthetic peptide comprising the carboxyl-terminal 53--84 region of human parathyroid hormone (PTH) have been studied. The immunoreactivity of the synthetic human PTH-(53--84) peptide paralleled that of a 53--84 fragment of the native human hormone prepared by enzymic digestion, in both a standard radioimmunoassay, which was not region-specific, and also a radioimmunoassay specific for the carboxyl-terminal region of PTH. However, in both types of radioimmunoassay the synthetic human PTH-(53--84) peptide was four to five times more reactive than the native human PTH-(53--84) fragment.
D006728:Hormones / Q000276:immunology*; D006801:Humans; D010281:Parathyroid Hormone / Q000276:immunology*; D010446:Peptide Fragments / Q000276:immunology; D011863:Radioimmunoassay
D006728:Hormones; D010281:Parathyroid Hormone; D010446:Peptide Fragments