[Brain catecholamine participation in etimizol activation of the hypophyseal-adrenal cortex system].
In the experiments on rats the influence of aethimizol on the blood plasma 11-corticosteroids level and the brain catecholamines content was studied. It is established that an hour after the aethimizol injection (10 mg/kg) the blood corticosteroids concentration increases and the hypothalamic norepinephrine and dophamine levels decrease. The pituitary-adrenal system stimulating effect of aethimizol is blocked to a great extent by the intraventricular injection of 6-hydroxydophamine (250 microgram, twice), but is not prevented by the intraperitoneal reserpine treatment (1.5 mg/kg, twice). Aethimizol potentiates the behavioral effects of L-dioxyphenylalanine in mice. It is suggested that the stimulating action of aethimizol on the pituitary-adrenal system may be attributed to its activation of the catecholamines release and their uptake by the hypothalamus.
D015062:11-Hydroxycorticosteroids / Q000097:blood; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000502:physiology*; D002395:Catecholamines / Q000502:physiology*; D004347:Drug Interactions; D005042:Etimizol / Q000494:pharmacology*; D006892:Hydroxydopamines / Q000008:administration & dosage; D007093:Imidazoles / Q000494:pharmacology*; D007980:Levodopa / Q000008:administration & dosage; D008297:Male; D051379:Mice; D010913:Pituitary-Adrenal System / Q000187:drug effects*; D051381:Rats; D012110:Reserpine / Q000008:administration & dosage; D013997:Time Factors
D015062:11-Hydroxycorticosteroids; D002395:Catecholamines; D006892:Hydroxydopamines; D007093:Imidazoles; D007980:Levodopa; D012110:Reserpine; D005042:Etimizol
Uchastie katekholaminov mozga v aktivatsii étimizolom sistemy gipofiz-kora nadpochechnikov.