PA-learning in young rats with dorsal hippocampal- and hippocampo-entorhinal atropine.
Twenty-one-day-old rats injected with atropine into dorsal hippocampus and trained on a white-black step-through passive avoidance task, did not perform differently from their controls in acquisition or extinction. In contrast, when atropine was administered into the ventral hippocampo-entorhinal area, the animals displayed a passive avoidance deficit. The results support the finding that the posteroventral but not the anterodorsal part of the hippocampal complex is implicated in passive avoidance learning and suggest a cholinergic mediation of this effect.
D000818:Animals; D001285:Atropine / Q000008:administration & dosage / Q000494:pharmacology*; D001362:Avoidance Learning / Q000187:drug effects*; D005108:Extinction, Psychological / Q000187:drug effects; D005260:Female; D006624:Hippocampus / Q000033:anatomy & histology; D007267:Injections; D008297:Male; D051381:Rats
D001285:Atropine