[Action of nonachlazine on thrombocyte aggregation induced by adrenaline].
Nonachlazine at concentrations 10(-6)--10(-4)M inhibited platelet aggregation in rabbits induced by adrenalin in vitro. The same concentrations of the drug produced an appreciable increase in aggregation reversibility. Intravenous injection of nonachlazine into the rabbit 50 minutes prior to adrenalin protected the platelets against the aggregation activity of adrenalin but did not affect deaggregation.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004837:Epinephrine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D066298:In Vitro Techniques; D009628:Nonachlazine / Q000494:pharmacology*; D010640:Phenothiazines / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D011817:Rabbits
D010640:Phenothiazines; D009628:Nonachlazine; D004837:Epinephrine
Issledovanie deĭstviia nonakhlazina na agregatsiiu trombotsitov, indutsirovannuiu adrenalinom.