[Effect of methotrexate on the expression of alloantigens in the population of murine lymph node cells].
The effect of methotrexate given intraperitoneally to (CBA X C57BL/6j) F1 mice on the expression of alloantigens in the lymphatic node cell population was investigated. For this purpose cells from intact or methotrexate-treated F1 mice were injected into the foot-pad of CBA mice. The reaction was estimated as an increase of the regional popliteal lymphatic node in comparison with contralateral (intact) one. The injection of methotrexate in doses of 50 and 75 mg/kg significantly increased the alloantigenicity of the F1 mouse lymphatic node cell population.
D000818:Animals; D002478:Cells, Cultured; D005260:Female; D007519:Isoantigens / Q000276:immunology*; D008198:Lymph Nodes / Q000166:cytology*; D008214:Lymphocytes / Q000276:immunology*; D008727:Methotrexate / Q000494:pharmacology*; D051379:Mice
D007519:Isoantigens; D008727:Methotrexate
Vliianie metotreksata na ékspressiiu alloantigenov v populiatsii kletok limfaticheskikh uzlov mysheĭ.