title: Molecular forms of cobalt-activated acylase in human tissues and serum of patients with viral hepatitis.
abstract: Two molecular forms of cobalt-activated acylase present in human tissues and one or three in sera of patients with viral hepatitis were noted. They have different substrate specificity. Only form 2 is strongly inhibited by alpha-hydroxyisocaproyl-tyrosine and -phenylalanine. Electrophoretic migrations of all enzyme forms are different from those of aminoacylase. Immunoglobulin antiform 2 of the acylase does not precipitate other forms of cobalt-activated acylase or aminoacylase.
mesh_terms: D000626:Aminopeptidases / Q000378:metabolism*; D000818:Animals; D000906:Antibodies; D003035:Cobalt / Q000494:pharmacology*; D004591:Electrophoresis, Polyacrylamide Gel; D005971:Glutamates; D006525:Hepatitis, Viral, Human / Q000201:enzymology*; D006801:Humans; D008099:Liver / Q000276:immunology; D008970:Molecular Weight
chemical_list: D000906:Antibodies; D005971:Glutamates; D003035:Cobalt; D000626:Aminopeptidases