[Improved method for the diagnosis of diabetes mellitus (author's transl)].
Based on a sample of 953 subjects without known metabolic abnormalities and a sample of 186 diabetics a classification rule was developed by a quadratic discriminant analysis. The measurements of blood glucose 1 and 2 h after the oral administration of 100 g oligosaccharids are used to classify the patients into the categories of "healthy", "suspect" and "diabetic". The rates of false positive and false negative classification were estimated from a second sample of 128 non-diabetic and 73 diabetics. By administration of 100 g oligosaccharids these rates were found to be 3.1% and 0%, respectively. An analogous study for the administration of 100 g glucose was based on a different sample of N = 472, 99 diabetics included. Misclassification rates were found to be 1.6% and 2.7%, respectively. For practical application of the rules two-dimensional netplanes are given.
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D003920:Diabetes Mellitus / Q000175:diagnosis*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D008297:Male; D008722:Methods; D008875:Middle Aged; D009844:Oligosaccharides / Q000008:administration & dosage / Q000378:metabolism
D001786:Blood Glucose; D009844:Oligosaccharides
Verbessertes Diagnoseverfahren zur Erkennung des Diabetes mellitus.