title: Changes in pyruvate kinase isozymes of rat small intestine during development and the synergistic effect on them of thyroid and glucocorticoid hormones.
abstract: Pyruvate kinase isozymes in rat small intestine changed markedly during the postnatal period. The activities of type M2 subunits rapidly increased before weaning, while those of type L subunits decreased slightly. The administration of hydrocortisone induced normal changes prematurely, whereas the administration of thyroxine increased their extent. On simultaneous administration, the two hormones had synergistic effects.
mesh_terms: D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D000833:Animals, Suckling; D006854:Hydrocortisone / Q000494:pharmacology*; D007421:Intestine, Small / Q000201:enzymology* / Q000254:growth & development; D007527:Isoenzymes / Q000378:metabolism*; D011441:Propylthiouracil / Q000494:pharmacology; D011770:Pyruvate Kinase / Q000378:metabolism*; D051381:Rats; D013974:Thyroxine / Q000494:pharmacology*
chemical_list: D007527:Isoenzymes; D011441:Propylthiouracil; D011770:Pyruvate Kinase; D013974:Thyroxine; D006854:Hydrocortisone