Carcinogenic effect of N-bis(2-hydroxypropyl)nitrosamine by a single administration in rats.
The carcinogenic effect of a single intraperitoneal injection of N-bis)2-hydroxypropyl)nitrosamine (BHP) was studied in male Wistar rats. Lung tumors (adenomas and adenocarcinomas) had the highest incidence (100%). Fewer neoplasms were induced in the thyroid (adenomas and adenocarcinomas, 36%), kidney (renal cell carcinomas, 8%), and the sigmoid colon (adenomas and adenocarcinomas, 9%). No pancreatic neoplasms were found.
D000230:Adenocarcinoma / Q000139:chemically induced; D000236:Adenoma / Q000139:chemically induced; D000818:Animals; D003110:Colonic Neoplasms / Q000139:chemically induced; D007274:Injections, Intraperitoneal; D007680:Kidney Neoplasms / Q000139:chemically induced; D008175:Lung Neoplasms / Q000139:chemically induced*; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009602:Nitrosamines / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D013964:Thyroid Neoplasms / Q000139:chemically induced
D009602:Nitrosamines