The structure of permetin A, a new polypeptin type antibiotic produced by Bacillus circulans.
The structure of permetin A(I), an antibiotic substance produced by Bacillus circulans AJ 3902, has been elucidated as a cyclic acyl peptide by means of the mass and nuclear magnetic resonance spectroscopic techniques. (Formula: see text.) The structure was found to be the same as polypeptin A(II) except that L-Thr in II is replaced by L-Ser in I. Details of the structural determination are given for the permetin A itself as well as for the hydrolyzed permetin A. (Formula: see text.)
D000900:Anti-Bacterial Agents / Q000096:biosynthesis; D001407:Bacillus / Q000378:metabolism; D055598:Chemical Phenomena; D002621:Chemistry; D005227:Fatty Acids / Q000032:analysis; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008968:Molecular Conformation; D010456:Peptides, Cyclic / Q000096:biosynthesis; D012694:Serine / Q000032:analysis
D000900:Anti-Bacterial Agents; D005227:Fatty Acids; D010456:Peptides, Cyclic; D012694:Serine