Antihypertensive effect of prazosin in combination with methyldopa, clonidine, or propranolol.
Seventeen hypertensive out-patients, more or less unresponsive to previous treatment with antihypertensive drugs, were treated in a cross-over fashion with placebo, prazosin (Pz), methyldopa (MD), Pz + MD, Pz + clonidine (C) and Pz + propranolol. The antihypertensive responses to Pz 2 mg t.i.d. and MD 250 mg t.i.d. were poor, and only modest when the drugs were combined. The combination of Pz with low doses of C was about as effective as Pz + MD, and some patients failed to respond to it. Nor was the combination of Pz + propranolol effective in those cases but the addition of a diuretic produced good responses in all patients. Side effects were few. It is concluded that a combination of central and peripheral sympathetic blockade does not necessarily produce normotension, and that a diuretic added to this combination greatly improves the response.
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D003000:Clonidine / Q000627:therapeutic use*; D004338:Drug Combinations; D004341:Drug Evaluation; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008750:Methyldopa / Q000627:therapeutic use*; D008875:Middle Aged; D010919:Placebos; D011224:Prazosin / Q000627:therapeutic use*; D011433:Propranolol / Q000627:therapeutic use*; D011799:Quinazolines / Q000627:therapeutic use*
D004338:Drug Combinations; D010919:Placebos; D011799:Quinazolines; D008750:Methyldopa; D011433:Propranolol; D003000:Clonidine; D011224:Prazosin