Effect of dipyridamole on prostaglandin-induced ocular hypertension in rabbits.
The effect of intraperitoneal injections of dipyridamole on the elevations of intraocular pressure and anterior chamber aqueous humor protein produced by topical application of prostaglandin E2 was studied in rabbits. Pretreatment with 100 mg/kg dipyridamole inhibited the prostaglandin E2--induced ocular hypertension and rise of aqueous humor protein. Systemic administration of dipyridamole did not alter the responses of the eye to instilled nitrogen mustard. Topical instillation of dipyridamole was ineffective. Dipyridamole, a clinically available drug, may be useful in the treatment of ocular inflammatory disease.
D000287:Administration, Topical; D000818:Animals; D001082:Aqueous Humor / Q000032:analysis / Q000187:drug effects; D004176:Dipyridamole / Q000008:administration & dosage / Q000494:pharmacology*; D005136:Eye Proteins / Q000032:analysis; D007274:Injections, Intraperitoneal; D007429:Intraocular Pressure / Q000187:drug effects*; D008466:Mechlorethamine / Q000494:pharmacology; D011458:Prostaglandins E / Q000494:pharmacology*; D011817:Rabbits
D005136:Eye Proteins; D011458:Prostaglandins E; D008466:Mechlorethamine; D004176:Dipyridamole