Experimental model for scleritis.
Rabbits were sensitized over a prolonged period to ovalbumin by intradermal injection. Ovalbumin was then injected into the limbus of the eye. A corneoscleral lesion, similar to necrotizing scleritis in humans, was produced. The clinical progression of the lesion is described and its histologic appearance discussed in relation to the human disease.
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D007249:Inflammation / Q000209:etiology / Q000473:pathology; D008297:Male; D010047:Ovalbumin / Q000276:immunology; D011817:Rabbits; D012590:Sclera / Q000276:immunology / Q000473:pathology
D010047:Ovalbumin