title: Cardiac lesions in intravenous drug addicts.
abstract: Postmortem findings in 25 intravenous addicts of centrally stimulating amines and centrally depressive narcotics (opiates) have been analysed with special reference to the presence of pathologic findings in the heart, and the cause of death. Most cases exhibited myocardial lesions of varying age, consistent with various phases of myofibrillar degeneration, such as hemorrhages, contraction bands, focal necroses, granulation tissue, stromal condensation, and scarring, indicating an active chronic process in the myocardium and the subendocardium, with a bias toward the conduction system of the heart. The lesions have been found in drug addicts who died immediately following an injection of narcotics as well as in those who, irrespective of their drug influence, have died following intervening injuries or disease. Cardiac lesions in drug addicts seem to have a variety of causative factors: infections, toxic influence, hypersensitivity, influence of catecholamines and general hypoxia. The authors feel that the two latter suggested causes appear most regularly and deserve special attention. The significance of these heart lesions seems to vary, but at times they may be the determining factor in the fatal outcome of a case.
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000150:complications; D000662:Amphetamines / Q000008:administration & dosage / Q000009:adverse effects*; D001344:Autopsy; D009202:Cardiomyopathies / Q000139:chemically induced* / Q000473:pathology; D004699:Endocardium / Q000473:pathology; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008694:Methamphetamine / Q000008:administration & dosage / Q000009:adverse effects*; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage / Q000009:adverse effects*; D009206:Myocardium / Q000473:pathology*; D019966:Substance-Related Disorders / Q000473:pathology*
chemical_list: D000662:Amphetamines; D008694:Methamphetamine; D009020:Morphine