title: Retinomotor activity and the c-wave of the hypoxic trout retina.
abstract: The teleost retina exhibits retinomotor activity in response to changing light intensity. We have shown that hypoxia interfers with normal retinomotor activity in the dark-adapted rainbow trout, so that the retina assumes an essentially light-adapted configuration with the cones contracted, the rods extended toward the pigmented epithelium, and epithelial pigment expanded. These cell movements appear to be correlated with the marked increase in ERG c-wave amplitude which we consistently observe during hypoxia in trout. Since the a-wave is not immediately affected by hypoxia, this increase in c-wave amplitude may be related to the movement of the rods toward the pigmented epithelium, which would cause a greater than normal change in extracellular [K+] near the apical membrane in response to a light stimulus, leading to an increase in c-wave amplitude.
mesh_terms: D000818:Animals; D002465:Cell Movement; D003623:Dark Adaptation; D004596:Electroretinography; D005399:Fishes; D000860:Hypoxia / Q000473:pathology / Q000503:physiopathology*; D008029:Lighting; D010507:Periodicity; D010786:Photoreceptor Cells / Q000473:pathology; D010857:Pigment Epithelium of Eye / Q000473:pathology; D012160:Retina / Q000473:pathology / Q000503:physiopathology*