RNase levels in golden hamster with DHPN induced pancreatic cancer.
Twenty Syrian golden hamsters recieved weekly injections of pancreatic cancer inducing DHPN. Their Poly (U) specific serum RNase levels were significantly elevated when compared to the control levels. Following salt fractionation, Poly (U) specific activity was present in both the 40% and 50% salt saturated fractions. Tissue assays showed that Poly (U) specific RNase was present in both pancreas and liver tissue extract, although the liver tissue RNase had a different pH maximum than that of the serum RNase.
D000230:Adenocarcinoma / Q000139:chemically induced / Q000201:enzymology*; D000818:Animals; D006224:Cricetinae; D008099:Liver / Q000201:enzymology; D008297:Male; D008647:Mesocricetus; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000201:enzymology; D009602:Nitrosamines; D010179:Pancreas / Q000201:enzymology; D010190:Pancreatic Neoplasms / Q000139:chemically induced / Q000201:enzymology*; D011437:Propylamines; D012260:Ribonucleases / Q000032:analysis*
D009602:Nitrosamines; D011437:Propylamines; C012457:diisopropanolnitrosamine; D012260:Ribonucleases