Scurvy and vitamin C deficiency in Crohn's disease.
A case of scurvy presenting in a patient with Crohn's disease is reported. A normal response to replacement therapy is seen. Vitamin C (ascorbic acid) deficiency was found in 7 out of 10 patients with clinically quiescent Crohn's disease, 4 of whom had an adequate oral intake of vitamin C. There was no significant difference in oral intake between patients with Crohn's disease and matched controls but there was a significant difference (P less than 0.001) in leucocyte ascorbic acid levels. It is recommended that patients with Crohn's disease be screened for vitamin C deficiency and receive prophylactic vitamin C supplements daily.
D000328:Adult; D001205:Ascorbic Acid / Q000097:blood / Q000627:therapeutic use; D001206:Ascorbic Acid Deficiency / Q000209:etiology*; D003424:Crohn Disease / Q000097:blood / Q000150:complications*; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000378:metabolism; D008297:Male; D012614:Scurvy / Q000188:drug therapy / Q000209:etiology*
D001205:Ascorbic Acid