Lead-induced leukocytosis in female mice.
Lead acetate was shown to stimulate a striking leukocytosis in young adult female mice. The effect was manifest 4 days after lead injection and continued throughout the following 4 days. At the higher treatment level, lead induced an increase of 300% for both monocytes and neutrophils. The leukocytosis was due primarily to the elevated levels of neutrophils as suggested by a decrease in the ratios of peripheral agranulocytes to granulocytes. No differences from normal leukocyte cytology were observed in blood samples collected from animals receiving lead.
D000818:Animals; D005260:Female; D007854:Lead / Q000494:pharmacology*; D007958:Leukocyte Count; D007964:Leukocytosis / Q000139:chemically induced*; D051379:Mice; D008813:Mice, Inbred ICR; D013997:Time Factors
D007854:Lead