title: Topical tretinoin therapy and oral lichen planus.
abstract: The treatment of severe forms of oral lichen planus is still relatively unsatisfactory. In this controlled study, 0.1% tretinoin in an adhesive base was used in 23 patients. Fifteen other control patients were similarly treated with the vehicle alone. In the tretinoin-treated group, 71% of the atrophic-erosive lesions improved while 29% improved from the vehicle (P less than .05). Reticular-plaque lesions improved in 74% from tretinoin and in 15% from the vehicle (P less than .001). Irritation from tretinoin occurs and thorough usage information is mandatory.
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D002610:Cheek; D005260:Female; D006801:Humans; D008010:Lichen Planus / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000188:drug therapy; D009061:Mouth Mucosa / Q000187:drug effects; D014212:Tretinoin / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D014801:Vitamin A / Q000031:analogs & derivatives*
chemical_list: D014801:Vitamin A; D014212:Tretinoin