title: Plasma renin activity during the development of paracetamol (acetaminophen) induced acute renal failure in man.
abstract: Plasma renin activity has been measured daily in 36 patients suffering from self poisoning with acetaminophen. In 3 developing porto-systemic encephalopathy terminal renal failure developed with high plasma renin activity. In 2 who developed acute renal failure without porto-systemic encephalopathy, plasma renin activity was noted to rise before serum creatinine and to return to initial levels after 3 or 4 days while renal failure persisted. Six other patients with similar hepatic damage showed comparable rises in renin without developing renal failure. Our findings are consistent with but do not establish a pathogenetic role for renin in acetaminophen-induced acute renal failure. It is suggested that other factors may act with renin to bring about renal failure.
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects*; D058186:Acute Kidney Injury / Q000097:blood / Q000139:chemically induced* / Q000473:pathology; D000293:Adolescent; D000328:Adult; D003404:Creatinine / Q000097:blood; D006501:Hepatic Encephalopathy / Q000150:complications; D006801:Humans; D007668:Kidney / Q000473:pathology; D008875:Middle Aged; D012083:Renin / Q000097:blood*
chemical_list: D000082:Acetaminophen; D003404:Creatinine; D012083:Renin