The influence of thyroxine administered in vivo on the transmembrane protonic electrochemical potential difference in rat liver mitochondria.
When mitochondria from normal and thyroxine-treated rats were energized by incubation with succinate, phosphate and MgCl2, it was found that the hormone treatment increased the transmembrane protonic electrochemical potential difference by 16mV and the respiration rate by 46%. Other experiments show these changes to be associated with increases in the intramitochondrial K+ and phosphate concentrations.
D000818:Animals; D004563:Electrochemistry; D007425:Intracellular Membranes / Q000187:drug effects / Q000502:physiology; D007477:Ions; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D013974:Thyroxine / Q000494:pharmacology*
D007477:Ions; D013974:Thyroxine