title: Familial occurrence of mitral valve prolapse in X-linked muscular dystrophy.
abstract: A high incidence of mitral valve prolapse (MVP) has been reported in patients with X-linked Duchenne muscular dystrophy. In our study MVP was present in six of 22 Duchenne dystrophy cases (27%) followed in the Maryland General Hospital Muscular Dystrophy Clinic. In addition, seven carriers of Duchenne and X-linked benign (Becker) dystrophy had evidence of MVP. Autosomal dominant transmission of MVP was present in four families. The unusually high prevalence of MVP in families with X-linked muscular dystrophy may have potential value in the recognition of the carrier trait.
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D008945:Mitral Valve Prolapse / Q000150:complications / Q000235:genetics*; D009136:Muscular Dystrophies / Q000150:complications / Q000235:genetics*; D010375:Pedigree; D012730:Sex Chromosomes; D014960:X Chromosome