(+)Nortrachelogenin, a new pharmacologically active lignan from Wikstroemia indica.
A new lignan, (+)-nortrachelogenin (I), and a known compound, daphnoretin were isolated from Wikstroemia indica C.A. Meyer (Thymelaeaceae). The structure of (+)-nortrachelogenin was established as 8(R)8'-4,4',8'-trihydroxy-3,3'-dimethoxylignan-olid, (9,9') on the basis of spectroscopic evidence and comparison with its enantiomer, (-)-nortrachelogenin. +-nortrachelogenin(I) showed effects on the central nervous system producing depression in rabbits.
D000818:Animals; D002490:Central Nervous System / Q000187:drug effects; D005663:Furans / Q000032:analysis; D006139:Guaiacol / Q000031:analogs & derivatives* / Q000032:analysis; D008694:Methamphetamine / Q000037:antagonists & inhibitors; D051379:Mice; D010946:Plants, Medicinal / Q000032:analysis*; D011817:Rabbits; D013237:Stereoisomerism; D013874:Thiopental / Q000494:pharmacology
D005663:Furans; D008694:Methamphetamine; D006139:Guaiacol; D013874:Thiopental