Comparison of the cardiovascular toxicity of three tricyclic antidepressant drugs: imipramine, amitriptyline, and doxepin.
Experiments were conducted on puppies to compare the cardiovascular toxicity of imipramine, amitriptyline, and doxepin. The drugs were infused at weekly intervals to produce arrhythmias and/or hypotension. Imipramine was less arrhythmogenic and caused less fall in blood pressure for a given dose than amitriptyline or doxepin.
D000639:Amitriptyline / Q000009:adverse effects*; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D002319:Cardiovascular System / Q000187:drug effects*; D004285:Dogs; D004316:Doxepin / Q000009:adverse effects*; D007022:Hypotension / Q000139:chemically induced; D007099:Imipramine / Q000009:adverse effects*; D007263:Infusions, Parenteral
D004316:Doxepin; D000639:Amitriptyline; D007099:Imipramine