The insulin receptor and insulin of the Atlantic hagfish. Extraordinary conservation of binding specificity and negative cooperativity in the most primitive vertebrate.
D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D002645:Chickens; D003847:Deoxyglucose / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism; D005399:Fishes / Q000378:metabolism*; D006196:Hagfishes / Q000378:metabolism*; D007328:Insulin / Q000378:metabolism* / Q000494:pharmacology; D007700:Kinetics; D051381:Rats; D011972:Receptor, Insulin / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013552:Swine
D007328:Insulin; D003847:Deoxyglucose; D011972:Receptor, Insulin