The effect of corticosteroids on in vitro endotoxin-induced microclots.
The in vitro endotoxin-induced fibrin microclots could be completely inhibited in blood by treating the patient with an oral dose of 30--60 mg prednisone 24 h before drawing the blood sample. When added to 100 ml blood in vitro, the minimal inhibiting dose of corticosteroid is 0.004 mg betamethasone or 0.5 mg hydrocortisone.
D001623:Betamethasone / Q000494:pharmacology; D001777:Blood Coagulation / Q000187:drug effects*; D004731:Endotoxins / Q000494:pharmacology*; D005337:Fibrin; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology; D066298:In Vitro Techniques; D011241:Prednisone / Q000494:pharmacology*; D012871:Skin Diseases / Q000097:blood*
D004731:Endotoxins; D005337:Fibrin; D001623:Betamethasone; D011241:Prednisone; D006854:Hydrocortisone