Iproniazid-induced biochemical changes in mice.
Single doses of iproniazid to Swiss-Webster mice caused a prolonged hypoglycemic reaction and transient biphasic changes in liver triglycerides. In contrast, the same dose of iproniazid in mice on a pyridoxine deficient diet elevated plasma glucose and FFA and liver FFA and TGL. Administration of the same dose of ipioniazid for 30 days elevated liver TGL in Swiss-Webster, C57/B1, DBA, and AKR mice; this effect was reversed in all but the AKR mice when the animals were maintained on a pyrodoxine-deficient diet.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000097:blood / Q000378:metabolism; D007490:Iproniazid / Q000494:pharmacology*; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013997:Time Factors; D014280:Triglycerides / Q000378:metabolism; D026681:Vitamin B 6 Deficiency / Q000378:metabolism
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D014280:Triglycerides; D007490:Iproniazid