title: Effect of estrogen on rate of 59Fe uptake by hemopoietic tissue in Japanese quail.
abstract: Injection of 2 mg estradiol valerate into male Japanese quail caused the rate of 59Fe uptake by the skeleton to drop 70% within 48 h. This phenomenon was due to an increase in the iron-binding capacity of the plasma induced by estrogen that caused a substantial decline in the availability of the label for hematopoiesis and to partial inhibition of hematopoiesis by estrogen directly. The changes in 59Fe uptake induced by estrogen were accompanied by a significant drop in circulating red blood cell concentration and a substantial rise in plasma volume. These altered physiological conditions were similar to those normally found in the laying hen.
mesh_terms: D000818:Animals; D001810:Blood Volume; D001853:Bone Marrow / Q000378:metabolism; D001842:Bone and Bones / Q000378:metabolism; D003370:Coturnix / Q000378:metabolism; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D006413:Hematopoietic System / Q000378:metabolism*; D007501:Iron / Q000378:metabolism*; D007504:Iron Radioisotopes; D008099:Liver / Q000378:metabolism; D008297:Male; D013154:Spleen / Q000378:metabolism
chemical_list: D007504:Iron Radioisotopes; D004958:Estradiol; D007501:Iron