Malignant fibrosarcomatous mesothelioma and benign pleural fibroma (localized fibrous mesothelioma) in tissue culture: a comparison of the in vitro pattern of growth in relation to the cell of origin.
Two cases of fibrous mesothelioma are presented. The first is a malignant tumor containing bundles of spindle-shaped cells with a dense reticulin network and nests of epithelial-like cells. The second is a benign tumor made up of spindle-shaped cells arranged in bundles with abundant reticulin and collagen fibers. Tissue culture in the first case revealed plagues similar to those formed by epithelial tumors. The second case had a fibroblastic pattern with single isolated spindle-shaped cells. These findings confirmed the mesothelial nature of fibrosarcomatous mesothelioma and supported the view that the so-called localized fibrous mesotheliomas could be fibroblastic neoplasms derived from the submesothelial connective tissue.
D000328:Adult; D046508:Culture Techniques; D005260:Female; D006801:Humans; D008297:Male; D008654:Mesothelioma / Q000473:pathology*; D008875:Middle Aged; D010997:Pleural Neoplasms / Q000473:pathology*