Presence of mast cell precursors in peripheral blood of mice demonstrated by parabiosis.
The presence of mast cell precursors in peripheral blood was examined. The beige C57BL/6 (bgj/bgj, Chediak-Higashi syndrome) mouse was parabiosed with the normal C57BL/6 mouse. Mast cells containing giant granules and originating in the beige partner appeared in the normal parabiont. A comparable proportion of normal-mouse-type mast cells developed in the beige parabiont as well. In spite of the low radiosensitivity of mature mast cells, irradiation of the normal parabiont reduced the proportion of normal-mouse-type mast cells appearing in the beige partner. It was concluded, therefore, that the precursors of mast cells can migrate through the bloodstream.
D000818:Animals; D002465:Cell Movement; D003594:Cytoplasmic Granules / Q000502:physiology; D008407:Mast Cells / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009504:Neutrophils / Q000502:physiology; D010227:Parabiosis