title: The presence and significance of the Thomsen-Friedenreich antigen in mammary gland. II. Its topochemistry in normal, hyperplastic and carcinoma tissue of the breast.
abstract: Normal tissue as well as various benign and malignant lesions of the breast were histochemically examined for the presence of the Thomsen-Friedenreich (TF)-antigen. Fluorescein- or 3H-labelled peanut agglutinin was used for this purpose, a lectin that is known to have a high affinity for the TF-antigen. The occurrence of this TF-antigen seemed in all cases, even in the carcinoma lobulare in situ that is regarded as being derived from myoepithelial cells by some authors, to be associated with a secretory condition. Its presence (free and neuraminic acid covered) in normal, hyperplastic and malignant breast tissue, however, cannot be considered a specific tumour associated antigen as has been previously assumed. Furthermore the investigations have shown that the intensity of fluorescence for peanut agglutinin (PNA)-receptors was generally stronger in differentiated carcinomas than in undifferentiated carcinomas of the breast. The histochemical findings are discussed with regard to diagnostical and immunotherapeutical aspects.
mesh_terms: D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D001940:Breast / Q000276:immunology* / Q000473:pathology; D001941:Breast Diseases / Q000276:immunology; D001943:Breast Neoplasms / Q000276:immunology*; D002278:Carcinoma in Situ / Q000276:immunology; D005260:Female; D006801:Humans; D006965:Hyperplasia; D007120:Immunochemistry; D037102:Lectins; D009439:Neuraminidase
chemical_list: D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D037102:Lectins; D009439:Neuraminidase