[Effect of tetracycline group antibiotics on the barrier properties of the small intestine epithelium].
The effect of 5 tetracyclines on the barrier and transport properties of the small intestine epithelium was studied. The barrier properties were estimated by a change in the ionic selectivity and conductivity of the epithelium, as well as by enterocyte linkage. The current of the short circuit served the characteristics of the Na transport system state. Dimethylchlortetracycline, methacycline and oxytetracycline in concentrations of 10(-7) g/ml decreased the epithelium conductivity and increased the cell linkage. Tetracycline and methacycline in concentrations of 10(-9) g/ml had an analogous effect. The effect was observed 10--20 minutes after the start of incubation with the substance. No effect on the current of the short circuit was observed within the concentrations of 10(-4) to 10(-9) g/ml. It is suggested that the decreased conductivity and increased linkage are due to adsorption of the tetracycline molecules in the region of close cell contacts.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002463:Cell Membrane Permeability / Q000187:drug effects; D004848:Epithelium / Q000187:drug effects; D066298:In Vitro Techniques; D007421:Intestine, Small / Q000187:drug effects*; D007473:Ion Channels / Q000187:drug effects; D007700:Kinetics; D051381:Rats; D012964:Sodium / Q000378:metabolism; D013754:Tetracyclines / Q000494:pharmacology*; D013997:Time Factors
D007473:Ion Channels; D013754:Tetracyclines; D012964:Sodium
Vliianie antibiotikov gruppy tetratsiklinov na bar'ernye svoĭstva épiteliia tonkoĭ kishki.