[Mode of action and tolerance of a single weekly dose of 1 mg of L-thyroxine for the prevention of recurrence of goiter].
After resection of euthyroid goiter, different doses of thyroxine administration for prophylaxis against recurrence were tested and compared. Group 1 (n = 30) received 1 mg L-thyroxine weekly; group 2 (n = 31), 0.1 mg L-thyroxine daily. The intermittent, high-dose thyroxine turned out to be equally effective as the conventional daily intake and showed no negative side effects.
D005500:Follow-Up Studies; D006042:Goiter / Q000517:prevention & control* / Q000601:surgery; D006801:Humans; D012008:Recurrence; D013974:Thyroxine / Q000008:administration & dosage*
D013974:Thyroxine
Wirkungsweise und Verträglichkeit einer wöchentlichen Einzeldosis von 1 mg L-Thyroxin zur Kropfrezidivprophylaxe.