The effects of psychotropic drugs and diuretics on blood glucose levels in diabetes mellitus.
It has been clearly established that most diuretics and most tranquilizers can raise blood glucose levels in diabetics, while antidepressants can lower them. The extent of these effects is variable but can be highly significant clinically. Chlorpromazine has very likely been responsible for a considerable increase in the prevalence of diabetes in hospitalized psychotics, while antidepressants can produce useful improvement of diabetic control, especially in brittle diabetics.
D001786:Blood Glucose / Q000378:metabolism*; D002746:Chlorpromazine / Q000009:adverse effects; D003920:Diabetes Mellitus / Q000097:blood*; D006801:Humans; D006943:Hyperglycemia / Q000139:chemically induced; D007003:Hypoglycemia / Q000139:chemically induced; D011619:Psychotropic Drugs / Q000009:adverse effects*; D014149:Tranquilizing Agents / Q000009:adverse effects
D001786:Blood Glucose; D011619:Psychotropic Drugs; D014149:Tranquilizing Agents; D002746:Chlorpromazine