Cyclophosphamide and collagen. The effect of cyclophosphamide on the biochemistry of collagen in granulation tissue, skin, and aorta. Experimental studies in rats and a discussion of the relevance of the observed results in relation to rheumatic diseases.
D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000378:metabolism; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D003094:Collagen / Q000302:isolation & purification / Q000378:metabolism*; D003238:Connective Tissue / Q000187:drug effects* / Q000378:metabolism; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004591:Electrophoresis, Polyacrylamide Gel; D006097:Granulation Tissue / Q000187:drug effects / Q000378:metabolism; D006900:Hydroxylation; D006909:Hydroxyproline / Q000378:metabolism; D008239:Lysine / Q000378:metabolism; D008297:Male; D011392:Proline / Q000378:metabolism; D051381:Rats; D012867:Skin / Q000187:drug effects / Q000378:metabolism; D013217:Starvation; D013997:Time Factors
D003520:Cyclophosphamide; D003094:Collagen; D011392:Proline; D008239:Lysine; D006909:Hydroxyproline