[An investigation on bacampicillin granules (author's transl)].
We investigated bacampicillin (BAPC) granules in the field of pediatrics. 1) Average serum levels after administration of BAPC granules at a dose of 10 mg/kg as ABPC were 6.8 mug/ml at 1 hour, 1.4 mug/ml at 6 hours. Average urinary excretion rate till 6 hours was 84.5%. Those results were almost same as those obtained with BAPC tablet. 2) We treated patients with acute tonsillitis, lacunar tonsillitis and acute bronchitis by BAPC granules at a dose of 30 approximately 40 mg potency/kg for 3 approximately 5 days, and excellent results were obtained. 3) In the case of streptococcal infections including scarlet fever, pharyngeal streptococci disappeared 1 approximately 2 days after administration and did not reappeared. 4) BAPC granules were easy to intake for children and no abnormal laboratory finding was observed. 5) BAPC granules seem to be useful for treatment of pediatric infections.
D000208:Acute Disease; D000667:Ampicillin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism; D001991:Bronchitis / Q000188:drug therapy / Q000378:metabolism; D004304:Dosage Forms; D006801:Humans; D012541:Scarlet Fever / Q000188:drug therapy / Q000378:metabolism; D014069:Tonsillitis / Q000188:drug therapy / Q000378:metabolism
D004304:Dosage Forms; D000667:Ampicillin; C011674:bacampicillin