Chromosomes and causation of human cancer and leukemia: XXXI. Dq- deletions and their significance in proliferative disorders.
Three cases with myeloproliferative disorders associated with Dq- deletions (13q- and 15q-) in their marrow cells are described. In addition, a summary of the experience with 14 cases of Dq- at Leuven, Belgium and the cases in the literature is presented. The findings indicate frequent involvement and susceptibility to deletion of the long arms of chromosomes No. 13 and No. 15 in lympho- and myeloproliferative disorders, thus adding these chromosomes to the list of those involved nonrandomly in human neoplasia.
D000328:Adult; D000368:Aged; D001854:Bone Marrow Cells; D002872:Chromosome Deletion; D002901:Chromosomes, Human, 13-15; D005260:Female; D006801:Humans; D007621:Karyotyping; D008214:Lymphocytes / Q000648:ultrastructure; D008232:Lymphoproliferative Disorders / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000235:genetics*; D009369:Neoplasms / Q000209:etiology