Penetration of oximes across the blood-brain barrier. A histochemical study of the cerebral cholinesterases reactivation.
The comparison of the effects of 4 oximes upon the cerebral cholinesterases reactivation after intoxication with paraoxon shows that the best results are obtained with toxogonine and 1574 [(carbaldoxime-4 pyridinium)-1(methyl-1 imidazolium-3)-3 propane]. The reactivation power of this latter compound seems due to the ease with which it can pass through the blood-brain barrier.
D000818:Animals; D001812:Blood-Brain Barrier; D001921:Brain / Q000201:enzymology*; D002802:Cholinesterases / Q000378:metabolism*; D010091:Oximes / Q000378:metabolism* / Q000494:pharmacology; D010261:Paraoxon / Q000037:antagonists & inhibitors; D051381:Rats; D013329:Structure-Activity Relationship
D010091:Oximes; D002802:Cholinesterases; D010261:Paraoxon