Variable attenuation of amphetamine effects by lithium.
In an open study of 8 subjects, approximately half showed some attenuation of CNS stimulant effects of amphetamine after pretreatment with lithium. Two showed specific blockade of euphoria, with persistence of some CNS stimulant effects. In 3 subjects lithium did not appear to affect the response to amphetamine. Lithium caused significant attenuation of the amphetamine-induced increase in systolic blood pressure for the group as a whole.
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D003913:Dextroamphetamine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D005059:Euphoria / Q000187:drug effects; D005260:Female; D006801:Humans; D008094:Lithium / Q000097:blood / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D011292:Premedication; D014705:Verbal Behavior / Q000187:drug effects
D008094:Lithium; D003913:Dextroamphetamine