[Activation of the anticoagulation system following intravenous administration of beta-thrombin].
Beta-thrombin possessing high esterase activity and tracing coagulating ability, being product of limited proteolysis of alpha-thrombin in vitro, accelerates recalcification time and thrombin generation in plasma, but not the conversion of prothrombin to enzyme. Thus, beta-thrombin is the activator of early stages of blood coagulation, does not possess fibrinolytic activity and does not activate plasminogen. The i. v. administration of beta-thrombin to rats induces changes in blood coagulability which are accompanied by an increase in plasma recalcification time, total fibrinolytic activity and non-enzymatic fibrinolysis. Nothing of the kind occurs after administration alpha-thrombin, having tracing clotting activity similar to R-thrombin activity. The data obtained suggest the possibility of reflex activation of the anticoagulating system by beta-thrombin or undirectly by alpha-thrombin generated by beta-thrombin activation at early stages of blood coagulation.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D005342:Fibrinolysis / Q000187:drug effects; D007275:Injections, Intravenous; D008297:Male; D051381:Rats; D013917:Thrombin / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
D013917:Thrombin
Aktivatsiia protivosvertyvaiushcheĭ sistemy posle vnutrivennego vvedeniia beta-trombina.