Ureterosigmoidostomy in rats: a model for the study of bladder tumour carcinogenesis and cocarcinogenesis.
A modified Coffey I ureterosigmoidostomy has been developed in rats as a model of urinary diversion for studying bladder carcinogenesis and co-carcinogenesis. Diverted and sham-operated animals were killed at 1, 3 and 6 months. Excretory urograms revealed minimal hydroureteronephrosis in most diverted animals. Upper tract bacterial colonisation was 9 times more frequent in diverted animals. Approximately one-third of the diverted animals had focal cortical scarring; however, renal function was normal in all groups as assessed by serum creatinine and electrolytes. These studies indicate that ureterosigmoidostomy in rats is a satisfactory model of urinary diversion for studying carcinogenesis.
D000818:Animals; D003043:Cocarcinogenesis; D012809:Colon, Sigmoid / Q000601:surgery; D005200:FANFT; D008297:Male; D051381:Rats; D014513:Ureter / Q000601:surgery; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced*; D014547:Urinary Diversion
D005200:FANFT