title: [Therapy of the metastasizing adenocarcinoma of the thyroid gland using 131-I. Experiences with 103 patients from 1963 to 1977 (author's transl)].
abstract: Results of 131-I therapy in 103 patients with metastatic thyroid cancer are analyzed. Therapy included: elimination of the thyroid or residual thyroid in case of previous surgery by application of about 80 mCi of 131-I and hormone substitution. About two months later, the hormone substitution was stopped. exogenous thyrotropine wsa given and 150--300 mCi of 131-I were applicated. Two days later, the thyroid medication was reinstituted, and a week later, the patient was studied by scintigraphy and other measures. In case of an iodine-metabolizing tumorous tissue, further 131-I applications were given. In the patients with distant metastases, the ten-year survival rate is about 22%. Small masses of papillary cancer can be eradicated in the majority by means of 131-I, whereas large tumor masses (several 100 g), can not be eliminated by 131-I. In well-differentiated follicular cancer, the recovery rate obtained by 131-I is lower than in papillary cancer. Manifestations of follicular cancer with anaplastic parts, or follicular cancer with eosinophilic cells or Hürthle-cell cancers could not be eradicated by 131-I. Treatment-induced mortality lies between 2 and 3% and is acceptable in view of the recovery rate and the serious nature of the disease.
mesh_terms: D000328:Adult; D000368:Aged; D005500:Follow-Up Studies; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011182:Postoperative Care; D013964:Thyroid Neoplasms / Q000532:radiotherapy* / Q000601:surgery
chemical_list: D007457:Iodine Radioisotopes
vernacular_title: Therapie des metastasierenden Schilddrüsenadenokarzinoms mit 131-Jod. Erfahrungen bei 103 Patienten aus dem Zeitraum 1963 bis 1977.