[R 33812 (domperidon) i.v. and orally as antiemetic adjuvans for short anaesthetics induced with etomidate. A comparative study (author's transl)].
R 33812 is being studied as an antiemetic adjuvant to anaesthesia for minor gynecological surgery. 150 patients received 10 mg Diazepam orally as a premedication and of these 3 groups of 50 received R 33812 in doses of 4 mg or 8 mg i.v. before anaesthesia or 10 mg orally together with premedication. Between series I and II a dose-related trend p = 0,065 was observed. No side effects were reported. The pharmacological interdependence of this combination is discussed as well as the consequences for general practice especially for the improved form of oral medication with R 33812.
D000759:Adjuvants, Anesthesia; D000284:Administration, Oral; D000932:Antiemetics / Q000008:administration & dosage / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000627:therapeutic use*; D003975:Diazepam; D004107:Dilatation and Curettage; D004347:Drug Interactions; D005045:Etomidate; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D010880:Piperidines / Q000627:therapeutic use*; D011292:Premedication
D000759:Adjuvants, Anesthesia; D000932:Antiemetics; D001562:Benzimidazoles; D010880:Piperidines; D003975:Diazepam; D005045:Etomidate
R 33812 (Domperidon) intravenös und oral als antiemetisches Adjuvans bei Etomidate-induzierten Kurznarkosen.