Endocrine abnormalities in thalassemia major.
Endocrine function evaluations in 16 patients with beta-thalassemia indicate that hypogonadotropic hypogonadism, hypoparathyroidism, and reduced adrenocorticotropic hormone reserve occur frequently, whereas reduced growth hormone and thyroid reserve are less common manifestations. Hemosiderosis-induced damage of the endocrine glands seems to be the main cause for endocrine dysfunction in the patients studied.
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004702:Endocrine Glands / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D006066:Gonads / Q000503:physiopathology; D006128:Growth; D006801:Humans; D007223:Infant; D008099:Liver / Q000473:pathology; D008297:Male; D010280:Parathyroid Glands / Q000503:physiopathology; D010902:Pituitary Gland / Q000503:physiopathology; D010913:Pituitary-Adrenal System / Q000503:physiopathology; D013789:Thalassemia / Q000473:pathology / Q000503:physiopathology*; D013961:Thyroid Gland / Q000503:physiopathology