Molecular connectivity analysis of hallucinogenic mescaline analogs.
The hallucinogenic (psychotomimetic) potency of 10 mescaline analogs was examined by molecular connectivity analysis. Potencies could be described by a two-term relating equation, which explained 94% of the variance in activity, on the basis of structural variation, 2,5-Dimethoxy substitution as well as the nature of the 4-position substituent played an important role in determining hallucinogenic potency. With the relating equation, reasonable potency predictions were made for six compounds not included in the initial investigation.
D006213:Hallucinogens; D006801:Humans; D008635:Mescaline / Q000031:analogs & derivatives* / Q000494:pharmacology; D008968:Molecular Conformation; D010627:Phenethylamines / Q000494:pharmacology; D013329:Structure-Activity Relationship
D006213:Hallucinogens; D010627:Phenethylamines; D008635:Mescaline