title: Influence on the depth of inhalation on the effect of the beta 2-receptor-stimulating drug fenoterol hydrobromide (berotec).
abstract: Study of the influence of different modes of administration of 200 microgram of fenoterol showed that in a selected group of patients, two thirds of the maximal obtainable decrease in airway resistance could be achieved within 3 min of local application of 200 microgram fenoterol onto the nasal mucosa, without inhalation into the lower airways. Aspects of the potential pathways by which inhaled substances reach their receptor or target sites are discussed.
mesh_terms: D000284:Administration, Oral; D000336:Aerosols; D000403:Airway Resistance / Q000187:drug effects*; D004983:Ethanolamines / Q000008:administration & dosage*; D005260:Female; D005280:Fenoterol / Q000008:administration & dosage*; D005541:Forced Expiratory Volume; D006321:Heart / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008168:Lung / Q000502:physiology; D008297:Male; D012119:Respiration; D013268:Stimulation, Chemical; D013990:Tidal Volume; D014797:Vital Capacity
chemical_list: D000336:Aerosols; D004983:Ethanolamines; D005280:Fenoterol