Cerebral arterial spasm: part 10. Reversal of acute and chronic spasm in dogs with orally administered nifedipine.
In vivo experiments in dogs demonstrated angiographically that the subarachnoid injection of blood produced cerebral arterial apasm both immediately after the injection of blood and 2 days later. The sublingual adminstration of nifedipine reversed both the acute and the delayed cerebral arterial spasm. In addition, sublingual administration of nifedipine 20 minutes before the subarachnoid injection of blood prevented the acute spasm.
D000208:Acute Disease; D000284:Administration, Oral; D000818:Animals; D002539:Cerebral Arterial Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology / Q000517:prevention & control; D002908:Chronic Disease; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D005260:Female; D008297:Male; D009543:Nifedipine / Q000008:administration & dosage* / Q000627:therapeutic use; D011725:Pyridines / Q000008:administration & dosage*; D011859:Radiography; D013035:Spasm / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology / Q000517:prevention & control; D013345:Subarachnoid Hemorrhage / Q000150:complications; D013997:Time Factors
D011725:Pyridines; D009543:Nifedipine