title: Adriamycin instillation therapy for bladder tumors.
abstract: Topical instillation of Adriamycin, 40 mg in 20 ml sterilized distilled water, was performed in 20 cases of bladder tumors every day for two weeks. In 8 cases (40%) the tumors disappeared completely, while in 5 cases (25%) tumors were reduced in size, but in 7 cases (35%) there was no effect. Therefore, the rate of effectiveness was 65%. The local bladder reaction and urethral pain were noted in all cases, as a result of which the therapy was interrupted in 2 cases. Abnormal values of red blood cells, white blood cells and platelets were not observed. In 3 cases the serum level of Adriamycin was only trace 1 or 2 hr after instillation. In conclusion, Mitomycin C was thought to be superior to Adriamycin as far as the effectiveness and irritability on the normal bladder epithelium were concerned.
mesh_terms: D000287:Administration, Topical; D002291:Carcinoma, Papillary / Q000188:drug therapy*; D004317:Doxorubicin / Q000008:administration & dosage* / Q000097:blood; D006801:Humans; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy*; D014546:Urinary Catheterization
chemical_list: D004317:Doxorubicin