title: Research related to the herbicide buvinol, especially for possible carcinogenicity.
abstract: The Budapest Chemical Works (Hungary) has conducted a study on a new herbicide called 'Buvinol', containing 2,4,5-trichlorophenoxyethanol (TCPE). In long-term carcinogenicity testing, the oral administration of the maximum tolerated dose of TCPE (70 mg/kg), containing 0.1 ppm 2,3,7,8-tetrachlorodibenzo-para-dioxin, increased the incidence of liver tumours in male mice, while smaller doses (1/10 and 1/100) did not. Dioxin in the dose range used (0.1--10 ppm) did not influence tumour frequency. Exposure of workers to TCPE during its production or use should be controlled and reduced.
mesh_terms: D015085:2,4,5-Trichlorophenoxyacetic Acid / Q000009:adverse effects* / Q000378:metabolism; D000818:Animals; D002273:Carcinogens; D004147:Dioxins / Q000009:adverse effects*; D005260:Female; D008113:Liver Neoplasms / Q000139:chemically induced*; D008297:Male; D008452:Maximum Allowable Concentration; D051379:Mice
chemical_list: D002273:Carcinogens; D004147:Dioxins; D015085:2,4,5-Trichlorophenoxyacetic Acid