Clinical studies on human pancreatic deoxyribonuclease I.
Duodenal juice collected after administration of Boot's pancreozymin and secretin to patients with various pancreatic diseases was subjected to deoxyribonuclease I (DNase I) assay, as well as measurements of total volume, amylase output and maximum bicarbonate concentration. It was observed that the DNase I output is well correlated with each of three factors. The DNase I output was much lower in patients with chronic pancreatitis or pancreatic cancer than in control subjects, and DNase I output was even found to be low in patients suspected of having chronic pancreatitis, who did not give abnormal resulsts with other assay methods. These results imply that DNase I output may be a good indicator of exocrine function of the pancreas, and thus may be useful for early detection of pancreatic diseases.
D000681:Amylases / Q000032:analysis; D001639:Bicarbonates / Q000378:metabolism; D002908:Chronic Disease; D003851:Deoxyribonucleases / Q000032:analysis*; D004386:Duodenum / Q000378:metabolism; D006801:Humans; D010179:Pancreas / Q000201:enzymology*; D010182:Pancreatic Diseases / Q000201:enzymology*; D010190:Pancreatic Neoplasms / Q000201:enzymology
D001639:Bicarbonates; D003851:Deoxyribonucleases; D000681:Amylases