[Effect of lithium oxybutyrate on the polypeptide and noradrenaline content in the rat hypothalamus].
It was established that single administration to rats of 200 mg/kg of lithium hydroxybutyrate releases noradrenalin from the terminals of hypothalamus adrenergic fibers and increases output of polypeptides in the neurons of supraoptic and paraventricular nuclei of the hypothalamus. After repeated administration of the drug (200 mg/kg) once a day over 6 days) the nuclei showed depressed output of polypeptides.
D000818:Animals; D006885:Hydroxybutyrates / Q000494:pharmacology*; D007031:Hypothalamus / Q000187:drug effects* / Q000378:metabolism; D008094:Lithium / Q000494:pharmacology*; D008297:Male; D009474:Neurons / Q000187:drug effects; D009638:Norepinephrine / Q000378:metabolism*; D010286:Paraventricular Hypothalamic Nucleus / Q000187:drug effects; D010455:Peptides / Q000378:metabolism*; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects; D013495:Supraoptic Nucleus / Q000187:drug effects; D013997:Time Factors
D006885:Hydroxybutyrates; D010455:Peptides; D011941:Receptors, Adrenergic; D008094:Lithium; D009638:Norepinephrine
Vliianie litiia oksibutirata na soderzhanie polipeptidov i noradrenalina v gipotalamuse krys.