2,4-diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline (tmq), a potent non-classical folate antagonist inhibitor--I effect on dihydrofolate reductase and growth of rodent tumors in vitro and in vivo.
D000818:Animals; D000970:Antineoplastic Agents; D005493:Folic Acid Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D066298:In Vitro Techniques; D007939:Leukemia L1210 / Q000188:drug therapy / Q000201:enzymology; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy; D011799:Quinazolines / Q000494:pharmacology* / Q000627:therapeutic use
D000970:Antineoplastic Agents; D005493:Folic Acid Antagonists; D011799:Quinazolines