[A case of melanoderma erroneously considered to be addisonian].
A case characterized by a dark pigmentation of the skin with an initial hypotension and a lung tuberculosis in the remote anamnesis is described. The skin pigment was formed by lipofuscin and emosiderin, but only the former was found in the liver biopsy. Anyway, the pigment was not melanine and the surrenalic function of the patient was completely normal; therefore, an Addisonism syndrome is excluded. The patient was treated for a very long time with DOCA: this caused hypertension, probably supported by the hypervolemia triggered by the DOCA depending retenction of sodium and water. A sure diagnosis of the case was not made, but an Addisonism syndrome was certainly excluded.
D000224:Addison Disease / Q000175:diagnosis*; D000328:Adult; D003900:Desoxycorticosterone / Q000009:adverse effects / Q000627:therapeutic use; D003937:Diagnosis, Differential; D003951:Diagnostic Errors; D005260:Female; D006801:Humans; D006973:Hypertension / Q000139:chemically induced; D010859:Pigmentation Disorders / Q000175:diagnosis* / Q000188:drug therapy; D012880:Skin Pigmentation
D003900:Desoxycorticosterone
Un caso di melanodermia erroneamente considerata addisoniana.