Female sex hormone receptors and their importance in clinical practice.
We now know a great deal about the early steps in the induction of a steroid hormone response at the cellular level. This helps to explain some of the observed clinical responses and also the development of some congenital anomalies. The importance of progesterone as a balance to the proliferative effects of extrogen both in hormone replacement therapy and in the hormone-sensitive tumors is clear. It is hoped that further studies will guide us to ways in which we might enhance these benefits.
D000328:Adult; D013734:Androgen-Insensitivity Syndrome / Q000503:physiopathology; D001667:Binding, Competitive; D004967:Estrogens / Q000627:therapeutic use; D005260:Female; D005833:Genital Neoplasms, Female / Q000503:physiopathology; D012739:Gonadal Steroid Hormones / Q000378:metabolism; D006801:Humans; D008593:Menopause / Q000187:drug effects; D008875:Middle Aged; D011374:Progesterone / Q000627:therapeutic use; D011944:Receptors, Androgen / Q000502:physiology*; D011960:Receptors, Estrogen / Q000502:physiology*; D011980:Receptors, Progesterone / Q000502:physiology*; D011987:Receptors, Steroid / Q000502:physiology*
D004967:Estrogens; D012739:Gonadal Steroid Hormones; D011944:Receptors, Androgen; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D011987:Receptors, Steroid; D011374:Progesterone