Autoimmune hemolytic anemia. 1. Warm antibody type.
Diagnosis of the idiopathic warm antibody type of autoimmune hemolytic anemia requires evidence for hemolysis and autoimmunity against RBC's ie, a positive direct antihuman globulin test. In addition, underlying disease states and drug therapy must be excluded as causative factors. Therapeutic measures are aimed at suppression of autoantibody production and include steroids (usually prednisone in tapering dosage), splenectomy, and less commonly, immunosuppressive agents.
D000368:Aged; D000744:Anemia, Hemolytic, Autoimmune / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy; D000918:Antibody Specificity; D001323:Autoantibodies / Q000032:analysis*; D003298:Coombs Test; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D013156:Splenectomy
D001323:Autoantibodies; D006454:Hemoglobins; D011241:Prednisone