The role of antiandrogenic action in cyproterone acetate-induced morphologic and biochemical changes in human semen.
Following the daily administration of 10 mg of cyproterone acetate to three normal fertile human volunteers for 12 to 16 weeks, there was a marked decrease in the count, motility, and cervical mucus-penetrating ability of spermatozoa, with a concomitant increase in abnormal and immature forms. The levels of seminal acid phosphatase and glycerylphosphoryl choline were also significantly decreased. Subsequently, concurrent daily administration of 75 mg of mesterolone increased the count, motility, and cervical mucus-penetrating ability of spermatozoa and stimulated the seminal biochemical constituents. The results indicate that the effects of a low dose of cyproterone acetate are due mainly to peripheral androgen deprivation.
D000135:Acid Phosphatase; D000328:Adult; D000726:Androgen Antagonists / Q000494:pharmacology*; D001219:Aspartate Aminotransferases / Q000097:blood; D002452:Cell Count; D003534:Cyproterone / Q000494:pharmacology*; D005997:Glycerylphosphorylcholine; D006801:Humans; D008297:Male; D008655:Mesterolone / Q000494:pharmacology; D012661:Semen / Q000032:analysis / Q000187:drug effects*; D013081:Sperm Motility / Q000187:drug effects; D013094:Spermatozoa
D000726:Androgen Antagonists; D008655:Mesterolone; D005997:Glycerylphosphorylcholine; D003534:Cyproterone; D001219:Aspartate Aminotransferases; D000135:Acid Phosphatase