[Kinetics of beta-methyl-digoxin in different degrees of renal function (author's transl)].
Creatinine clearance was evaluated in individuals with varying degrees of renal function following the administration of beta-methyl-digoxin. From the results of the experiment it can be deduced that significantly increased hematic values and renal clearance values definitely lower than normal appear only in patients of a creatinine clearance of less than 50 ml/min. Furthermore, a positive correlation between creatinine clearance values and beta-methyl-digoxin levels was noticed. This correlation was in proportion to the amount of serum albumin. The degree of distribution of free digitalis and digitalis bound to proteins within the vascular system played an important role in the complex kinetics of digoxin. This relationship is suggested as an indirect index of the proportions of free beta-methyl-digoxin and of beta-methyl-digoxin bound to plasma proteins.
D003404:Creatinine / Q000652:urine; D004077:Digoxin / Q000031:analogs & derivatives*; D006801:Humans; D007668:Kidney / Q000187:drug effects; D007674:Kidney Diseases / Q000503:physiopathology*; D007677:Kidney Function Tests; D008520:Medigoxin / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology* / Q000652:urine; D011485:Protein Binding; D013997:Time Factors
D004077:Digoxin; D003404:Creatinine; D008520:Medigoxin
Cinética de la beta-metil-digoxina en los diversos grados de funcionalismo renal.