title: Guard against unpredictable drug responses in the aging.
abstract: Altered and unexpected responses to treatment can be caused by physiologic changes that occur with aging. These changes can affect the absorption, distribution, metabolism, and elimination of drugs. Changes in renal function, body composition, and the gastrointestinal tract are variables influencing a drug's mechanism of action. To avoid therapeutic problems, understanding these variables is essential.
mesh_terms: D000042:Absorption; D000368:Aged; D000639:Amitriptyline / Q000009:adverse effects; D001463:Barbiturates / Q000009:adverse effects; D002400:Cathartics / Q000009:adverse effects; D004088:Dihydroergotoxine / Q000009:adverse effects; D004347:Drug Interactions; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D005853:Geriatrics; D006801:Humans; D008297:Male; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000378:metabolism; D011955:Receptors, Drug
chemical_list: D001463:Barbiturates; D002400:Cathartics; D004364:Pharmaceutical Preparations; D011955:Receptors, Drug; D004088:Dihydroergotoxine; D000639:Amitriptyline