title: Experience in the laboratory detection of the carrier state of classic hemophilia.
abstract: The predictive odds for suspected carriers of hemophilia have been calculated using data derived from normal and known carrier populations. For each individual, the concentration of Factor VIII-related antigen and Factor VIII biological (procoagulant) activity was measured and the data were studied by linear discriminant analysis. Forty-five suspected carriers were evaluated, with 31 percent (14/45) classified as carriers. Using Factor VIII procoagulant activity alone, 18 percent (8/45) appeared as carriers, while the ratio method of activity level to antigen level showed 44 percent (20/45).
mesh_terms: D000293:Adolescent; D000328:Adult; D000941:Antigens / Q000032:analysis / Q000276:immunology; D001777:Blood Coagulation; D005169:Factor VIII / Q000032:analysis / Q000276:immunology / Q000502:physiology; D005260:Female; D006580:Genetic Carrier Screening; D006467:Hemophilia A / Q000097:blood / Q000175:diagnosis* / Q000235:genetics; D006801:Humans
chemical_list: D000941:Antigens; D005169:Factor VIII