Iron deficiency prevents liver toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin.
The compound 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes hepatocellular damage and porphyria in C57B1/6J mice, among a wide range of toxic effects. We compared the effect of TCDD toxicity in iron-deficient mice with that in mice receiving a normal diet. Porphyria did not develop in the iron-deficient animals, and these animals were also protected from hepatocellular damage and certain other toxic effects of TCDD.
D000818:Animals; D004147:Dioxins / Q000633:toxicity*; D004790:Enzyme Induction; D000090463:Iron Deficiencies; D008099:Liver / Q000473:pathology; D051379:Mice; D008862:Microsomes, Liver / Q000201:enzymology; D006899:Mixed Function Oxygenases / Q000378:metabolism; D000072317:Polychlorinated Dibenzodioxins / Q000633:toxicity*; D011164:Porphyrias / Q000139:chemically induced*; D014575:Uroporphyrinogen Decarboxylase / Q000378:metabolism
D004147:Dioxins; D000072317:Polychlorinated Dibenzodioxins; D006899:Mixed Function Oxygenases; D014575:Uroporphyrinogen Decarboxylase