Conductivity and hardness changes in aged compacts.
Batches of sodium, potassium, and ammonium chloride tablets containing no excipients and spray-dried lactose tablets containing 0.5% magnesium stearate were stored at 20 and 76% relative humidity. Electrical resistance and hardness measurements were made within 1 hr after compression and at intervals during a 45-day period. Hardness values of sodium, potassium, and ammonium chloride tablets stored at 20% relative humidity increased from 70 to 200% at 45 days, while conductances decreased 10-fold. Tablets stored at 76% relative humidity showed no increases or slight decreases in hardness with slight increases in conductance. Lactose tablets decreased slightly in hardness with corresponding increases in conductance.
D000643:Ammonium Chloride; D004339:Drug Compounding; D004356:Drug Storage; D004553:Electric Conductivity; D006244:Hardness; D006813:Humidity; D007785:Lactose; D011189:Potassium Chloride; D012965:Sodium Chloride; D013607:Tablets; D013997:Time Factors
D013607:Tablets; D000643:Ammonium Chloride; D012965:Sodium Chloride; D011189:Potassium Chloride; D007785:Lactose