title: Failure of thiopental to modify global anoxic injury.
abstract: To corroborate thiopental protection from cerebral anoxia after cardiopulmonary arrest, 23 sedated, curarized, adult dogs were asphyxiated by plugging the endotracheal tube. Cardiopulmonary resuscitation (CPR) was started 7 minutes after electrocortical silence. Twelve animals received no other treatment (controls), 10 regained consciousness and spontaneous respirations, but remained decerebrate, blind, unable to drink or feed. Two dogs returned to a normal neurologic state. Ten dogs were treated with thiopental after CPR, 7 received 15 mg/kg the first minute, followed by 23 mg/kg over 1 hour; 3 received 60 mg/kg in the first 3 minutes, followed by 30 mg/kg over 1 hour. Except for 1 dog in the low-dose group that recovered neurologically, thiopental-treated dogs showed no neurological or survival improvement over the controls.
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000473:pathology; D003128:Coma / Q000401:mortality; D003655:Decerebrate State / Q000473:pathology; D004285:Dogs; D006324:Heart Arrest, Induced; D002534:Hypoxia, Brain / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D009410:Nerve Degeneration / Q000187:drug effects; D013874:Thiopental / Q000627:therapeutic use*
chemical_list: D013874:Thiopental