Inhibition of lymphocyte cytotoxicity and mitogen-induced transformation of lymphocytes by human skin homogenates.
Limitation of the inflammatory cascade has been demonstrated in man by an inhibitor(s) of the prostaglandin system and by inhibitor(s) for chemotaxis of leukocytes. Other factors may exist in vivo that inhibit other inflammatory sequences. In this report, homogenates from human skin interfered with 2 standard assays of lymphocyte function, mitogen-induced transformation and cytotoxicity while homogenates of human placenta did not. Differential centrifugation studies located inhibitory factor(s) primarily in the nuclear fractions. Therefore, reversible transitory depressions of the cell-mediated immune response that are observed concomitantly with chronic dermatoses may reflect release of inhibitory material dermatitic skin in vivo.
D003602:Cytotoxicity, Immunologic; D006801:Humans; D007962:Leukocytes / Q000276:immunology*; D008213:Lymphocyte Activation; D010924:Placental Extracts / Q000276:immunology; D012867:Skin / Q000032:analysis / Q000276:immunology* / Q000648:ultrastructure; D013347:Subcellular Fractions / Q000276:immunology; D014020:Tissue Extracts / Q000276:immunology*
D010924:Placental Extracts; D014020:Tissue Extracts