Effects of RMI 12,936 on some reproductive processes in the female golden hamster.
A single subcutaneous injection of 2 mg RMI 12,936 (17 beta-hydroxy-7 alpha-methylandrost-5-en-3-one) given a day after estrus disrupted estrous cycle for over 30 days and inhibited ovulation in 100 percent of treated Golden hamsters. Administration of RMI 12,936 (2 mg) on Day 6 of pregnancy caused termination of pregnancy within 4 days of treatment. In association with the termination of pregnancy was a significant reduction in the concentrations of progesterone and estradiol-17 beta together with an elevated testosterone level. After termination of pregnancy by RMI 12,936, the hamsters remained sexually receptive for 4 weeks but failed to conceive. It is concluded that RMI 12,936 causes termination of pregnancy due to an induction of functional luteolysis.
D000022:Abortion, Spontaneous / Q000139:chemically induced; D000818:Animals; D006224:Cricetinae; D004958:Estradiol / Q000097:blood; D004970:Estrone / Q000097:blood; D004971:Estrus / Q000187:drug effects*; D005260:Female; D008297:Male; D008647:Mesocricetus; D008696:Methandrostenolone / Q000009:adverse effects / Q000494:pharmacology*; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D012726:Sexual Behavior, Animal / Q000187:drug effects; D013739:Testosterone / Q000097:blood
D004970:Estrone; D013739:Testosterone; D011374:Progesterone; D004958:Estradiol; D008696:Methandrostenolone