title: Comparative nephrotoxicity of gentamicin and netilmicin: functional and morphological correlations with urinary enzyme activities.
abstract: An increase in urinary enzyme activities reflected biopsy confirmed aminoglycoside nephrotoxicity (proximal tubular injury) before changes in blood urea nitrogen, serum creatinine, urinary osmolality and urinary protein excretion. Netilmicin, a semisynthetic derivative of gentamicin, was less nephrotoxic than gentamicin.
mesh_terms: D000118:Acetylglucosaminidase / Q000652:urine; D000818:Animals; D004285:Dogs; D004798:Enzymes / Q000652:urine*; D005839:Gentamicins / Q000633:toxicity*; D005966:Glucuronidase / Q000652:urine; D007668:Kidney / Q000187:drug effects / Q000473:pathology*; D008297:Male; D009113:Muramidase / Q000652:urine; D009428:Netilmicin / Q000633:toxicity*; D011507:Proteinuria
chemical_list: D004798:Enzymes; D005839:Gentamicins; D009428:Netilmicin; D009113:Muramidase; D005966:Glucuronidase; D000118:Acetylglucosaminidase