Release of slow-reacting substance from anaphylactic lung tissue and its modification by beta-sympathomimetics.
Anaphylactic release of slow-reacting substance of anaphylaxis (SRS-A) from chopped guinea pig lung was studied. The antibodies mediating the anaphylactic reaction were classified as IgG antibodies by PCA technique. Isoprenaline was found to inhibit the release of SRS-A in the concentration range 10-8-10-6M, while the beta2-selective agonist terbutaline showed inhibition in the concentration range 10-6-10-5M. The beta1-selective beta-agonist tazolol was ineffective when tested in the concentration range 10-7-10-5M. The rank order of inhibitory potency of the compounds on SRS-A release agree with that for histamine release.
D000818:Animals; D005260:Female; D007082:Ileum / Q000502:physiology; D007545:Isoproterenol / Q000494:pharmacology; D008168:Lung / Q000473:pathology*; D008297:Male; D051379:Mice; D009119:Muscle Contraction; D010323:Passive Cutaneous Anaphylaxis; D013189:SRS-A / Q000378:metabolism*; D013566:Sympathomimetics / Q000494:pharmacology*; D013726:Terbutaline / Q000494:pharmacology
D013189:SRS-A; D013566:Sympathomimetics; D007545:Isoproterenol; D013726:Terbutaline