Demonstration of steroid-producing gonadal tumors by external scanning with the use of NP-59.
Bilateral testicular Leydig cell tumors in a patient with Nelson's syndrome and a Leydig cell tumor of the ovary in a woman with a virilizing syndrome were successfully imaged with [6beta-131I]iodomethyl-19-norcholest-5(10)-en-3beta-ol (NP-59). Uptake by these tumors was comparable to uptake by adrenal glands in patients with funtioning adrenal tumors or bilateral hyperplasia. Scanning the gonads with NP-59 may be a helpful imaging procedure in localizing possible sites for exploratory surgery in certain cases of gonadal neoplasia.
D000301:Adosterol; D000311:Adrenal Glands / Q000000981:diagnostic imaging; D000328:Adult; D005260:Female; D006729:Hormones, Ectopic / Q000096:biosynthesis; D006801:Humans; D007457:Iodine Radioisotopes; D007984:Leydig Cell Tumor / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D009347:Nelson Syndrome / Q000150:complications; D010051:Ovarian Neoplasms / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D013261:Sterols; D013736:Testicular Neoplasms / Q000000981:diagnostic imaging*; D014770:Virilism / Q000150:complications
D006729:Hormones, Ectopic; D007457:Iodine Radioisotopes; D013261:Sterols; D000301:Adosterol