A preliminary report on the treatment of intestinal schistosomiasis with oxamniquine.
Oxamniquine proved to be an efficient drug for the treatment of Schistosoma mansoni in adults. The cure rate obtained with a single oral dose of 15 mg/kg was 81.3 per cent. With 15 mg given b.d. for a single day the cure rate was 90 per cent. Post-treatment reduction of egg count was 93.7 and 95 per cent respectively within three months follow-up period. The drug, given by the oral route, was well tolerated, non-toxic, and side-effects were evanescent. Further studies are needed to indicate its use for mass treatment and control of schistosomiasis.
D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009600:Nitroquinolines / Q000627:therapeutic use*; D010073:Oxamniquine / Q000009:adverse effects / Q000627:therapeutic use*; D012550:Schistosoma mansoni; D012552:Schistosomiasis / Q000188:drug therapy*
D009600:Nitroquinolines; D010073:Oxamniquine