Inhibitory effect of cytokinins on PHA-induced human lymphocyte stimulation.
The inhibitory effect of various purine derivatives on PHA-induced human lymphocyte blast formation was studied. Two nucleoside cytokinins, N6-benzyladenosine and N6-isopentenyladenosine, inhibited blast formation at concentrations as low as 10(-6) M. However, the other cytokinins, which lacked the ribosyl residue at N9 position, had to be at the higher molar concentration of 10(-4) before they could induce the same inhibitory effect.
D000241:Adenosine / Q000031:analogs & derivatives / Q000494:pharmacology; D003583:Cytokinins / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis; D006801:Humans; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000187:drug effects*; D010835:Phytohemagglutinins / Q000037:antagonists & inhibitors*; D010937:Plant Growth Regulators / Q000494:pharmacology*; D011685:Purine Nucleotides / Q000494:pharmacology; D011687:Purines / Q000494:pharmacology
D003583:Cytokinins; D010835:Phytohemagglutinins; D010937:Plant Growth Regulators; D011685:Purine Nucleotides; D011687:Purines; D004247:DNA; D000241:Adenosine