[Chenodeoxycholic acid therapy and colorectal carcinoma--an experimental approach (author's transl)].
With respect to the potential significance of bile acids in the pathogenesis of colorectal cancer the effect of continuous oral administration of chenodeoxycholic acid--which is used for conservative therapy of radiolucent gallstones--on the rate of colonic tumors was examined. In rats treated with chenodeoxycholic acid a higher incidence of 1,2-dimethylhydrazine induced adenocarcinomas was detected. On the basis of these results it is postulated that all patients treated with chenodeoxycholic acid due to gallstones are registered systematically in order to gain definite information about its possible role as tumor promoter.
D000818:Animals; D002277:Carcinoma / Q000139:chemically induced* / Q000473:pathology; D002635:Chenodeoxycholic Acid / Q000009:adverse effects*; D003110:Colonic Neoplasms / Q000139:chemically induced* / Q000473:pathology; D004127:Dimethylhydrazines; D004357:Drug Synergism; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology; D051381:Rats; D012004:Rectal Neoplasms / Q000139:chemically induced* / Q000473:pathology; D013997:Time Factors
D004127:Dimethylhydrazines; D002635:Chenodeoxycholic Acid
Orale Chenodesoxycholsäuretherapie und kolorektales Karzinom--eine experimentelle Studie.