[Changes in the transverse striated musculature during treatment with the pesticide, Neguvon, and TMB-4 reactivator].
The authors found that the contractile activity of isolated myofibers as-well as superprecipitation of myosin B were reduced after intoxication of white rats with 1/2 of dose of LD50 of neguvon. The reaktivator of cholinesterase TMB-4 (20 mg/kg) recovered the contractile capability of myofibres even on the third day after treatment, but superprecipitation of myosin B-after the twentieth day.
D000818:Animals; D002801:Cholinesterase Reactivators / Q000494:pharmacology*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009124:Muscle Proteins / Q000378:metabolism; D009132:Muscles / Q000187:drug effects*; D009210:Myofibrils / Q000187:drug effects; D010091:Oximes / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors; D014236:Trichlorfon / Q000494:pharmacology*; D014289:Trimedoxime / Q000494:pharmacology*
D002801:Cholinesterase Reactivators; D009124:Muscle Proteins; D010091:Oximes; D014289:Trimedoxime; D014236:Trichlorfon
Promeni v naprechnonabrazdenata muskulatura pri tretirane s pestitsida neguvon i reaktivatora TMB-4.