[Decorporation of radionuclides investigations on the pharmacokinetics of DTPA by means of its decorporating effect on 144Cer (author's transl)].
The influence of Zn-DTPA on the retention of 144Cer in several organs of the rat was investigated 4 days after 144Cer application either with intact or with prevented renal excretion. As the 144Cer activity mobilized from the liver is recovered in gut and faeces an excretion of DTPA bount 144Cer with the bile can be assumed. In animals with impeded renal function an amount of 144Cer is accumulated in blood and extracellular water which corresponds to that mobilized from the skeleton and is normally excreted with the urine.
D000818:Animals; D001769:Blood; D002565:Cerium Radioisotopes / Q000378:metabolism*; D005110:Extracellular Space / Q000032:analysis; D005243:Feces / Q000032:analysis; D005260:Female; D007676:Kidney Failure, Chronic / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D004369:Pentetic Acid / Q000494:pharmacology*; D051381:Rats
D002565:Cerium Radioisotopes; D004369:Pentetic Acid
Dekorporation von Radionukliden. Uber die Eliminierung von inkorporiertem 144Cer mittels Zn-DTPA bei normaler und gestörter Nierenfunktion.