title: Sperm count depression in pesticide applicators exposed to dibromochloropropane.
abstract: Male pesticide applicators who worked with the nematocide dibromochloropropane (DBCP) were examined to determine the possible testicular toxicity from this exposure. Infertility and azoospermia which were first noted among factory workers exposed to DBCP were not observed among the applicators. Sperm count depression, however, was associated with the duration of exposure in the current year but not with exposure in past years. The extent of exposure to DBCP in the current year was also associated with an elevation of serum follicle stimulating hormone (FSH) but not of luteinizing hormone (LH). Sperm count depression was limited to applicators involved in irrigation setup work and in the calibration of equipment. These results suggest that the testicular toxicity of DBCP for men may occur in a shorter period than was previously reported, that the effect may be reversible in men with mild sperm count depression, and that public health measures might be directed at controlling specific application techniques.
mesh_terms: D000969:Antinematodal Agents / Q000009:adverse effects*; D002140:California; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D006846:Hydrocarbons, Halogenated / Q000009:adverse effects*; D007248:Infertility, Male / Q000139:chemically induced*; D007306:Insecticides / Q000009:adverse effects*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009784:Occupational Diseases / Q000139:chemically induced*; D011407:Propane / Q000009:adverse effects / Q000031:analogs & derivatives*; D013091:Spermatogenesis / Q000187:drug effects*
chemical_list: D000969:Antinematodal Agents; D006846:Hydrocarbons, Halogenated; D007306:Insecticides; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; C007318:1,2-dibromo-3-chloropropane; D011407:Propane