Oxygen transport in a woman with hemoglobin Hope/beta+ thalassemia.
Because their blood may "unload" oxygen more readily than normal, people with hemoglobin of low oxygen affinity might be expected to be anemic. We have studied a woman with hemoglobin Hope/beta+ thalassemia, whose hemoglobin level was 10.4 to 12.3 gm/dl (normal 14 +/- 2) despite a P50 of 41 mm Hg (normal 26). Her cardiac index was normal, yielding a calculated mixed venous PO2 of 51 mm Hg (normal 34 to 49). Oxygen transport in patients with low oxygen affinity can be maintained by a variety of homeostatic responses, only one of which is altered erythropoiesis.
D000328:Adult; D001692:Biological Transport; D005260:Female; D006455:Hemoglobins, Abnormal; D006801:Humans; D010100:Oxygen / Q000097:blood*; D013789:Thalassemia / Q000097:blood*
D006455:Hemoglobins, Abnormal; D010100:Oxygen