title: Development and reversal of a proteoglycan aggregation defect in normal canine knee cartilage after immobilization.
abstract: Healthy adult dogs were studied for a defect in proteoglycan aggregation by immobilizing one limb for varying periods of time. Immobilization for 6 days resulted in a 41% reduction in proteoglycan synthesis by articular cartilage from the restrained knee compared with the contralateral control knee. After 3 weeks of immobilization, proteoglycan aggregation was no longer demonstrable in cartilage from the constrained limb. The aggregation defect was rapidly reversible and aggregates were again normal size 2 weeks after removal of a cast that had been worn for 6 weeks.
mesh_terms: D000818:Animals; D002357:Cartilage Diseases / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D002358:Cartilage, Articular / Q000378:metabolism* / Q000473:pathology; D002499:Centrifugation, Density Gradient; D002850:Chromatography, Gel; D004285:Dogs; D007103:Immobilization; D007719:Knee Joint / Q000378:metabolism / Q000473:pathology; D011509:Proteoglycans / Q000096:biosynthesis / Q000302:isolation & purification / Q000378:metabolism*; D013997:Time Factors
chemical_list: D011509:Proteoglycans