title: Wells' syndrome. Recurrent granulomatous dermatitis with eosinophilia.
abstract: Two cases of granulomatous dermatitis with eosinophilla (Wells' syndrome) are reported. With Wells' original four cases, these two cases define a distinctive dermatosis with onset as cellulitis and formation of solid edema and either final spontaneous resolution or resolution with steroid therapy. Microscopic study showed diffuse tissue eosinophilia and fibrinoid flame figures, evolution of associated focal necrobiosis, and formation of focal microgranulomas associated with eosinophils. Biopsy of muscle and fascia showed comparable fasciitis and eosinophilic myositis. Immunofluorescence in one case disclosed fibrin in the dermis and lgM, lgA, and C3 in the blood vessels of the muscle. Recurrences of the lesions often appeared to be related to drug administration or surgery.
mesh_terms: D000368:Aged; D003176:Complement C3 / Q000032:analysis; D003872:Dermatitis / Q000150:complications* / Q000276:immunology / Q000473:pathology; D004802:Eosinophilia / Q000150:complications*; D005260:Female; D006099:Granuloma / Q000150:complications* / Q000276:immunology / Q000473:pathology; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008875:Middle Aged; D012008:Recurrence; D012867:Skin / Q000473:pathology; D013577:Syndrome
chemical_list: D003176:Complement C3; D007070:Immunoglobulin A; D007075:Immunoglobulin M