[Effect of an intravenously administered phosphatidylserine emulsion on blood coagulation and blood system indices].
Experiments on white rats and rabbits showed that intravenous injection of phosphatidylethanol amine- and sphyngomyelin-stabilized phosphatidylserin emulsion produced hypocoagulemia. The effect was observed immediately after injection of the drug, reached a maximum after one hour and returned to normal following 24 hours. The changes became more intensive as the dose was increased and could be reproduced during repeated administrations over a period of ten days. The arterial blood pressure, velocity of the blood flow and volume of the circulating blood remained unchanged. There were no appreciable changes in the peripheral blood parameters or in bone marrow hemopoiesis on repeated administrations over a period of thirty days.
D000818:Animals; D001769:Blood / Q000187:drug effects*; D001777:Blood Coagulation / Q000187:drug effects*; D001780:Blood Coagulation Tests; D001853:Bone Marrow / Q000187:drug effects; D004338:Drug Combinations; D004655:Emulsions; D006410:Hematopoiesis / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D007275:Injections, Intravenous; D010714:Phosphatidylethanolamines / Q000494:pharmacology; D010718:Phosphatidylserines / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D013109:Sphingomyelins / Q000494:pharmacology; D013997:Time Factors
D004338:Drug Combinations; D004655:Emulsions; D010714:Phosphatidylethanolamines; D010718:Phosphatidylserines; D013109:Sphingomyelins
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