Rank order of sarcoma susceptibility among mouse strains reverses with low concentrations of carcinogen.
Ten mouse strains in which aryl hydrocarbon hydroxylase can be induced, or F1 hybrids of these strains, were ranked according to their sarcoma susceptibility when exposed to a high concentration (5 percent) of the chemical carcinogen 3-methylcholanthrene. This rank order was reversed when the concentration of 3-methylcholanthrene was reduced to 0.05 percent.
D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D005796:Genes; D008297:Male; D008748:Methylcholanthrene; D051379:Mice; D008815:Mice, Inbred Strains / Q000502:physiology*; D012513:Sarcoma, Experimental / Q000139:chemically induced* / Q000276:immunology
D008748:Methylcholanthrene; D001189:Aryl Hydrocarbon Hydroxylases