Dry coating of intraocular lenses with bovine submaxillary mucin.
Uncoated intraocular lenses caused extensive corneal endothelial cell damage after in vitro contact (mean, 30.9% cell loss), whereas lenses coated with bovine submaxillary mucin type 1 caused minimal cell loss (mean 4.3%). No observable in vivo toxicity in the eye occurred when 0.1 ml of 3, 6, or 9% solution was injected into the anterior chamber. Mucin-coated lenses can be sterilized by ethylene oxide with no measurable adsorbence into the coating. Scanning electron microscopy confirmed the results from vital staining.
D000818:Animals; D003316:Corneal Diseases / Q000517:prevention & control*; D004727:Endothelium / Q000187:drug effects; D005123:Eye / Q000187:drug effects; D007910:Lenses, Intraocular / Q000592:standards*; D008689:Methacrylates; D008855:Microscopy, Electron, Scanning; D009077:Mucins / Q000494:pharmacology / Q000627:therapeutic use* / Q000633:toxicity; D011817:Rabbits; D013499:Surface Properties
D008689:Methacrylates; D009077:Mucins