Postinflammatory and malignant protein patterns in aqueous humour.
Normal aqueous humour and the aqueous humour of patients with cataract is virtually protein-free. Patients having retinoblastoma and non-malignant postinflammatory lesions show significantly high quantities of proteins in the aqueous humour. Retinoblastoma is associated with an increase in the globulin content and an albumin/globulin ratio below unity, while non-malignant postinflammatory intraocular conditions show a rise of the albumin fraction with an albumin/globulin ratio above unity. It seems likely that the leakage of protein into the aqueous is different in the two conditions, and a transcellular route is postulated as being the cause in malignant conditions. The estimation of protein patterns in the aqueous humour may be of value in the diagnosis of intraocular malignancy.
D001082:Aqueous Humor / Q000032:analysis* / Q000201:enzymology; D002386:Cataract / Q000378:metabolism; D005128:Eye Diseases / Q000378:metabolism*; D005131:Eye Injuries / Q000378:metabolism; D005134:Eye Neoplasms / Q000032:analysis*; D005136:Eye Proteins / Q000032:analysis*; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D009363:Neoplasm Proteins / Q000032:analysis*; D012175:Retinoblastoma / Q000032:analysis*
D005136:Eye Proteins; D009363:Neoplasm Proteins; D007770:L-Lactate Dehydrogenase