An inherited mild middle-aged adiposity in wild mice.
In a warfarin-resistant population of wild mice reared in the laboratory, a dominant gene for adiposity, Ad, was found to segregate. The onset of obesity is at 4--6 months, and adipose mice suffer from hyperinsulinaemia; the sexes differ in penetrance, males having greater penetrance then females. Linkage backcrosses show the gene to be situated on chromosome 7 with about 25% recombination with the closely linked warfarin-resistance genes War, and frizzy, fr. The finding of adipose in two other wild populations also carrying War is discussed as an ecological and physiological problem.
D000828:Animal Population Groups / Q000235:genetics*; D000818:Animals; D000835:Animals, Wild / Q000235:genetics*; D004351:Drug Resistance; D005260:Female; D005799:Genes, Dominant; D008040:Genetic Linkage; D008297:Male; D051379:Mice; D008820:Mice, Obese / Q000235:genetics*; D009765:Obesity / Q000235:genetics / Q000662:veterinary*; D014859:Warfarin / Q000494:pharmacology
D014859:Warfarin