[Effect of fosfomycin-Na on reproductive performance of rats. III. Peri- and post-natal examination (author's transl)].
The peri- and post-natal study of fosfomycin-Na (FOM-Na) was undertaken in Wistar rats. FOM-Na was administered intraperitoneally at dose levels of 250, 750 and 1,500 mg/kg/day from day 14 of gestation to day 21 after delivery. It could be concluded that delivery rate in the 750 and 1,500 mg/kg groups decreased, but no influence of FOM-Na was found on postnatal development of offspring (F1) and neonate (F2) without maximum dose.
D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development; D000900:Anti-Bacterial Agents / Q000633:toxicity*; D005260:Female; D005298:Fertility / Q000187:drug effects; D005333:Fetus / Q000187:drug effects; D005578:Fosfomycin / Q000008:administration & dosage / Q000633:toxicity*; D007774:Lactation / Q000187:drug effects; D008297:Male; D011247:Pregnancy; D051381:Rats; D012098:Reproduction / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D005578:Fosfomycin