Procainamide-induced agranulocytosis and thrombocytopenia.
Procainamide therapy has frequently been reported as a cause of agranulocytosis, but severe thrombocytopenia associated with the use of this drug has been noted only once. We report a case of simultaneously occurring agranulocytosis and profound thrombocytopenia in a patient receiving procainamide hydrochloride. Different mechanisms appeared to be responsible for the two cytopenias.
D000368:Aged; D000380:Agranulocytosis / Q000139:chemically induced*; D001161:Arteriosclerosis / Q000188:drug therapy; D006801:Humans; D008297:Male; D011342:Procainamide / Q000009:adverse effects* / Q000627:therapeutic use; D013921:Thrombocytopenia / Q000139:chemically induced*
D011342:Procainamide