title: Variant angina in the setting of hypothyroidism and beta blockade: a proposed mechanism.
abstract: Coronary artery spasm can occur in the presence of excessive alpha-adrenergic tone. A decrease in protective coronary vasodilator substance and enhanced alpha-adrenergic responsiveness, which occurs in the setting of hypothroidism and beta blockade, predisposes to coronary artery spasm. The case presented supports these concepts.
mesh_terms: D000368:Aged; D000787:Angina Pectoris / Q000139:chemically induced* / Q000188:drug therapy; D000788:Angina Pectoris, Variant / Q000139:chemically induced* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000150:complications* / Q000503:physiopathology; D011433:Propranolol / Q000009:adverse effects*
chemical_list: D011433:Propranolol