title: A new chemical series active against African trypanosomes: benzyltriphenylphosphonium salts.
abstract: Antitrypanosomal activity for benzyltriphenylphosphonium salts is reported for the first time. Testing was conducted using Trypanosoma rhodesiense infected mice. Of 70 phosphorus-containing compounds tested, 21 were active. Sixteen of these active chemical species were benzyltriphenylphosphonium salts. Four were nonbenzyl triphenyl compounds. The remaining active drug was a benzyldiphenylphosphonium salt.
mesh_terms: D009861:Onium Compounds / Q000494:pharmacology; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013730:Terphenyl Compounds / Q000494:pharmacology / Q000627:therapeutic use; D014344:Trypanocidal Agents / Q000627:therapeutic use; D014353:Trypanosomiasis, African / Q000188:drug therapy
chemical_list: D009861:Onium Compounds; D009943:Organophosphorus Compounds; D013730:Terphenyl Compounds; D014344:Trypanocidal Agents