Chromosome mutations and chromosome stability in children treated with different regimes of immunosuppressive drugs.
The chromosome mutations and the number of sister chromatid exchanges induced by different kinds of immunosuppressive treatment were investigated in children and adults with certain types of renal diseases. The aim of the study was to find among the treatment schedules those promising good therapeutic results with the least mutagenic effects. A slightly decreased chromosome stability was found in the patients treated by cyclophosphamide therapy.
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002699:Chlorambucil / Q000009:adverse effects / Q000627:therapeutic use; D002842:Chromatids / Q000187:drug effects; D002869:Chromosome Aberrations; D003520:Cyclophosphamide / Q000009:adverse effects / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D015122:Mercaptopurine / Q000009:adverse effects / Q000627:therapeutic use; D009153:Mutagens; D009404:Nephrotic Syndrome / Q000188:drug therapy / Q000235:genetics; D011239:Prednisolone / Q000009:adverse effects / Q000627:therapeutic use; D014747:Vinblastine / Q000009:adverse effects / Q000627:therapeutic use
D007166:Immunosuppressive Agents; D009153:Mutagens; D002699:Chlorambucil; D014747:Vinblastine; D003520:Cyclophosphamide; D011239:Prednisolone; D015122:Mercaptopurine