title: [Patterns of the cytogenetic changes in the peripheral blood lymphocytes of children immunized against smallpox and parotitis].
abstract: A positive correlation between the frequency of acrocentric chromosome associations (AChA) and the accumulation of antibody titers in children immunized against smallpox and parotiditis has been discovered. The decrease of AChA in proliferating lymphocytes is accompanied with the lowering of D/G ratio due to group G predomination in AChA. The aberration frequency was kept unchanged throughout the whole observation of children immunized against parotiditis. A lower degree of cytogenic alterations in lymphocytes and accumulation of titers of antibodies in children immunized against paratiditis, as compared with those in the other group, may suggest a weak immunological effect of the given inoculative preparation.
mesh_terms: D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D002901:Chromosomes, Human, 13-15 / Q000648:ultrastructure; D002904:Chromosomes, Human, 21-22 and Y / Q000648:ultrastructure; D006801:Humans; D007111:Immunity, Cellular; D007114:Immunization; D007125:Immunogenetics; D008214:Lymphocytes / Q000648:ultrastructure*; D009107:Mumps / Q000235:genetics*; D009108:Mumps Vaccine / Q000008:administration & dosage; D012899:Smallpox / Q000235:genetics*; D012900:Smallpox Vaccine / Q000008:administration & dosage; D013997:Time Factors
chemical_list: D009108:Mumps Vaccine; D012900:Smallpox Vaccine
vernacular_title: Nekotorye zakonomernosti tsitogeneticheskikh izmeneniĭ v limfotsitakh perifericheskoĭ krovi u deteĭ, immunizirovannykh protiv ospy i parotita.