[Pharmacology of oral anticoagulants].
The present view on the mechanism of vitamin K-dependent synthesis of the clotting factors II, VII, IX and X in the liver and its inhibition by 4-hydroxycoumarine and 1,3-indandione-type anticoagulants is given. The discovery of gamma-carboxyglutamyl residues in intact clotting factors and the role of this amino acid as the calcium-binding principle is pointed out. After general considerations on the pharmacokinetics of coumarine-type anticoagulants detailed information on the pharmacokinetics of phenprocoumon, almost exclusively used in the GDR, is presented. The importance of pharmacokinetic aspects for control of oral anticoagulation is emphasized. As a possible tool for evaluation of individual pharmacokinetic parameters during already ongoing medication the additional administration of a single dose of radioactively labelled anticoagulant is proposed. Toxic effects in case of overdosage, untoward reactions and interference with oral anticoagulants by comedication are described.
D000284:Administration, Oral; D000925:Anticoagulants / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D003374:Coumarins / Q000008:administration & dosage / Q000494:pharmacology / Q000633:toxicity; D005164:Factor IX / Q000096:biosynthesis; D005167:Factor VII / Q000096:biosynthesis; D005170:Factor X / Q000096:biosynthesis; D006801:Humans; D007189:Indans / Q000008:administration & dosage / Q000494:pharmacology / Q000633:toxicity; D008099:Liver / Q000378:metabolism; D011516:Prothrombin / Q000096:biosynthesis; D013329:Structure-Activity Relationship; D014812:Vitamin K / Q000037:antagonists & inhibitors
D000925:Anticoagulants; D003374:Coumarins; D007189:Indans; D014812:Vitamin K; D005167:Factor VII; D011516:Prothrombin; D005164:Factor IX; D005170:Factor X
Pharmakologie der oralen Antikoagulantien.