Effects of anti-inflammatory drugs on platelet aggregation in rabbits.
Effects of non-steroidal anti-inflammatory drugs (aspirin, indimethacin, flufenamic acid, tiaramide and HG-70) on rabbit platelet aggregation were studied using Evans aggoregometer and a modified form of Chandler's loop method. Tiaramide in 10(-4) and 10(-5)M inhibited effectively the aggregation caused by ADP in the optical density method and accelerated the restoration of the time course of disaggregation in the loop method. The other 4 drugs were ineffective. In collagen-induced aggregation all 5 drugs inhibited the aggregation. Among them tiaramide was most potent. Only tiaramide prolonged the time taken to induce snow storm and aggregates in the loop method.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D052160:Benzothiazoles; D003094:Collagen / Q000494:pharmacology; D004347:Drug Interactions; D066298:In Vitro Techniques; D008297:Male; D008722:Methods; D010879:Piperazines / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects*; D011817:Rabbits; D013844:Thiazoles / Q000494:pharmacology
D000893:Anti-Inflammatory Agents; D052160:Benzothiazoles; D010879:Piperazines; D013844:Thiazoles; D000244:Adenosine Diphosphate; D003094:Collagen; C003468:tiaramide