title: Basal-cell tumors of the lumbar skin after radiotherapy for arthrosis.
abstract: Twenty-three cases of basal-cell tumor of the skin arising in the lumbar-sacral region after repeated irradiations in anti-inflammatory doses for arthrosis are discussed. The involved cutaneous region had been submitted to a number of roentgenotherapy cycles, varying from a minimum of 2 to a maximum of 10. The total dose absorbed at skin level varied between 14.4 and 72.0 Gy, administered over 2 to 6 years. Thirteen to 30 years (median, 19) had elapsed since the end of the irradiations. This observation compels a critical re-evaluation to be made concerning certain radiotherapy indications. The treatment of these lesions involves some problems: radiotherapy is made difficult by the coexistence of often serious dystrophic lesions on the surrounding skin, and surgery is often unsuccessful. The topic application of 5-fluorouracil ointment seems to achieve good results.
mesh_terms: D000287:Administration, Topical; D000368:Aged; D002280:Basal Cell Carcinoma / Q000209:etiology* / Q000628:therapy; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007592:Joint Diseases / Q000532:radiotherapy*; D008161:Lumbosacral Region; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000209:etiology* / Q000628:therapy; D009381:Neoplasms, Radiation-Induced / Q000628:therapy; D011879:Radiotherapy Dosage; D012878:Skin Neoplasms / Q000209:etiology* / Q000628:therapy; D013997:Time Factors
chemical_list: D005472:Fluorouracil