The influence of chlordimeform on calcium and glucose homeostasis.
The effects of single and repeated administration of chlordimeform on calcium and glucose homeostasis were examined in the rat. A single injection of chlordimeform (100 mg/kg, i.p.) produced a rapid 15 percent decrease in plasma calcium and a 64 percent rise in plasma glucose. The administration of chlordimeform (75 mg/kg, i.p., twice daily) over a period of 7 days caused an 8 percent reduction in plasma calcium, a 50 percent decrease in duodenal calcium transport and a 20 percent decrease in body weight.
D000578:Amidines / Q000494:pharmacology*; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D001786:Blood Glucose / Q000378:metabolism; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism; D002118:Calcium / Q000097:blood / Q000378:metabolism*; D002742:Chlorphenamidine / Q000494:pharmacology*; D004386:Duodenum / Q000187:drug effects / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D006706:Homeostasis / Q000187:drug effects; D008297:Male; D051381:Rats; D013997:Time Factors
D000578:Amidines; D001786:Blood Glucose; D002742:Chlorphenamidine; D005947:Glucose; D002118:Calcium