Plasma cinnarizine levels resulting from oral administration as capsule or tablet formulation investigated by gas-liquid chromatography.
1 A gas chromatographic assay for the estimation of therapeutic concentrations of cinnarizine in plasma is described. 2 Cinnarizine (75 mg) was administered orally to twelve healthy subjects in the form of capsules and tablets on two separate occasions. No difference was found in the plasma levels or absorption of cinnarizine from these formulations. 3 The mean plasma elimination half-life of cinnarizine was 3.24 h.
D000284:Administration, Oral; D000328:Adult; D002214:Capsules; D002849:Chromatography, Gas; D002936:Cinnarizine / Q000008:administration & dosage / Q000097:blood*; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D008722:Methods; D010879:Piperazines / Q000097:blood*; D013607:Tablets; D013997:Time Factors
D002214:Capsules; D010879:Piperazines; D013607:Tablets; D002936:Cinnarizine