[Investigations about the influence of halothane and enflurane on the nuclear metabolism of bronchial mucosa cells of the dog (author's transl)].
The influence of halothane and enflurane on the nuclear metabolism of bronchial mucosa cells was investigated over ten hours on 5 dogs each anaesthetized with halothane or enflurane. Desoxyribonucleinic acid (DNS) and, for the arginine and lysine-rich histone fraction the basic amino-acids arginine and lysine were measured. During the ten hours of anesthesia there was a decrease of all patterns, reversible in a control 48 hours after the end of anesthesia. The decrease of DNS and arginine was similar to each other, but that of lysine was delayed. The results indicate a reversible retardation of the nuclear metabolism. The site of action is probably in the activated zone of nucleus.
D000818:Animals; D001120:Arginine / Q000032:analysis; D001980:Bronchi / Q000166:cytology; D002467:Cell Nucleus / Q000378:metabolism*; D004247:DNA / Q000032:analysis; D004285:Dogs; D004737:Enflurane / Q000494:pharmacology*; D004847:Epithelial Cells; D006221:Halothane / Q000494:pharmacology*; D008239:Lysine / Q000032:analysis; D008297:Male; D008738:Methyl Ethers / Q000494:pharmacology*
D008738:Methyl Ethers; D004247:DNA; D004737:Enflurane; D001120:Arginine; D008239:Lysine; D006221:Halothane
Untersuchungen über den Einfluss der Inhalationsanaesthetika Halothane und Enflurane auf den Stoffwechsel im Zellkern des Bronchialepithels beim Hund.