Paradoxical intraocular pressure response to pilocarpine. A proposed mechanism and treatment.
A patient with unilateral angle-recession glaucoma had an ipsilateral increased intraocular pressure (IOP) with miotics despite open angles, and decreased IOP with cycloplegics. The following mechanism is proposed to explain these findings: Pilocarpine hydrochloride has been demonstrated experimentally to increase trabecular outflow and decrease uveoscleral outflow. In this eye with a severely compromised and unresponsive trabecular outflow, miotics served to impair uveoscleral outflow and cause a net rise in IOP. Similarly, an increase in uveoscleral outflow with cycloplegics served to decrease IOP. The use of atrophine sulfate in these rate cases may be of therapeutic value in lieu of systemic or surgical therapy.
D001285:Atropine / Q000627:therapeutic use; D003519:Cyclopentolate / Q000494:pharmacology; D004456:Echothiophate Iodide / Q000494:pharmacology; D005901:Glaucoma / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D010656:Phenylephrine / Q000494:pharmacology; D010862:Pilocarpine / Q000009:adverse effects*
D010862:Pilocarpine; D010656:Phenylephrine; D001285:Atropine; D004456:Echothiophate Iodide; D003519:Cyclopentolate