Rapid, stability-indicating, high-pressure liquid chromatographic determination of theophylline, guaifenesin, and benzoic acid in liquid and solid pharmaceutical dosage forms.
Theophylline, guaifenesin, and benzoic acid were determined by reversed-phase high-pressure liquid chromatography without interference from active and/or vehicle decomposition. A degradation product of sucrose, 5-hydroxymethylfurfural, can be identified and quantified in liquid samples simultaneously.
D001565:Benzoates / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D004338:Drug Combinations; D004355:Drug Stability; D006140:Guaifenesin / Q000032:analysis*; D008722:Methods; D012996:Solutions / Q000032:analysis; D013607:Tablets / Q000032:analysis; D013806:Theophylline / Q000032:analysis*
D001565:Benzoates; D004338:Drug Combinations; D012996:Solutions; D013607:Tablets; D006140:Guaifenesin; D013806:Theophylline