title: Heterogeneity of hemoglobin gamma chains in normal newborns and in cases of alpha and beta thalassemia.
abstract: The ratio of Ggamma to Agamma was studied in 13 normal healthy newborns and in eight neonates with hydrops fetalis due to homozygous alpha-thalassemia. The findings in the normal healthy newborns agreed with those of earlier reports. In homozygous alpha-thalassemia the Ggamma and Agamma ratio appeared generally lower than in healthy control newborns, but one of the hydrops fetalis cases had a very high Ggamma value. In all 13 normal healthy newborns, in 8 patients with homozygous alpha-thalassemia, and in 4 patients with homozygous beta-thalassemia, Tgamma chains with threonine at position 75 were detected in addition Igamma chains with isoleucine at position 75. In homozygous alpha-thalassemia, the Tgamma-to-Igamma ratio seemed lower and in homozygous beta-thalassemia higher than in normal newborns.
mesh_terms: D000409:Alanine / Q000378:metabolism; D003488:Cyanogen Bromide / Q000494:pharmacology; D005319:Fetal Hemoglobin / Q000235:genetics*; D005998:Glycine / Q000378:metabolism; D006720:Homozygote; D006801:Humans; D007231:Infant, Newborn; D010455:Peptides; D013789:Thalassemia / Q000097:blood* / Q000235:genetics; D014357:Trypsin / Q000494:pharmacology
chemical_list: D010455:Peptides; D005319:Fetal Hemoglobin; D014357:Trypsin; D000409:Alanine; D003488:Cyanogen Bromide; D005998:Glycine