Pyridoxine treatment of chemical diabetes in pregnancy.
Thirteen women with chemical diabetes diagnosed in late pregnancy were found to excrete excessive amounts of urinary xanthurenic acid after a tryptophan load, indicative of a relative pyridoxine (vitamin B6) deficiency. Treatment with 100 mg pyridoxine daily for 14 to 23 days restored the urinary xanthurenic acid excretion to normal in all patients. Improvement of glucose tolerance was observed in only two of the patients studied, deterioration in six, and no significant change in the remaining five. The insulin response to glucose was unaltered during pyridoxine therapy.
D000328:Adult; D005260:Female; D006801:Humans; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000150:complications / Q000188:drug therapy*; D011736:Pyridoxine / Q000627:therapeutic use*; D026681:Vitamin B 6 Deficiency / Q000150:complications
D011736:Pyridoxine