title: Gynaecomastia in two prepubertal boys with congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency.
abstract: Two male children with congenital adrenal hyperplasia due to a 11-beta-hydroxylase defect are described, in whom gynaecomastia developed before institution of therapy, or when the treatment was inadequate. Cortisone in appropriate doses caused the gynaecomastia to disappear.
mesh_terms: D000293:Adolescent; D000312:Adrenal Hyperplasia, Congenital; D000308:Adrenocortical Hyperfunction / Q000150:complications; D003348:Cortisone / Q000627:therapeutic use; D006177:Gynecomastia / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D007223:Infant; D008297:Male; D006899:Mixed Function Oxygenases / Q000172:deficiency*
chemical_list: D006899:Mixed Function Oxygenases; D003348:Cortisone