title: Airway response to hair spray in normal subjects and subjects with hyperreactive airways.
abstract: Short-term 20-second exposure to hair sprays A and B failed to show significant decreases in maximum expiratory flow rates at low pulmonary volumes in normal subjects; however, significant decreases were observed with hair spray B in eight subjects with hyperractive airways (abnormal response to inhalation of methacholine). On the partial flow-volume curves, flows at 40 percent and 25 percent of forced vital capacity decreased 8.9 to 10.3 percent and 14 to 18.7 percent, respectively. The hair sprays differed in their content of perfume and plasticizer, and since the latter is generally considered nontoxic at room temperature, the perfume may be the responsible agent. It would appear from this study that normal healthy individuals are at little risk, at least from brief exposure to hair spray; however, in the presence of hyperreactive airways, as seen in asthmatic subjects and in some people with allergic rhinitis and viral respiratory infections, an immediate response of the airways may result from exposure to some hair sprays.
mesh_terms: D000336:Aerosols; D001249:Asthma / Q000503:physiopathology; D001980:Bronchi / Q000187:drug effects*; D003358:Cosmetics / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008449:Maximal Expiratory Flow-Volume Curves; D008688:Methacholine Compounds; D012130:Respiratory Hypersensitivity / Q000503:physiopathology*; D012141:Respiratory Tract Infections / Q000503:physiopathology; D006255:Rhinitis, Allergic, Seasonal / Q000503:physiopathology; D014777:Virus Diseases / Q000503:physiopathology
chemical_list: D000336:Aerosols; D003358:Cosmetics; D008688:Methacholine Compounds