title: High steady-state levels of uric acid produced in rats by dietary training and potassium oxonate.
abstract: To reduce the inherent variability in serum uric acid levels of animals allowed ad libitum exposure to food containing potassium oxonate and uric acid, male Sprague-Dawley rats were trained to eat their daily food allotment in a 1.25-hr period each morning. After training the rats were fed a food mixture containing 5% potassium oxonate and 2% uric acid (w/w each). Serum blood levels of uric acid reached a steady state within 2 hr; these levels were maintained for an additional 4 hr. It is believed that the stomach emptying rate is a zero-order process under these experimental conditions.
mesh_terms: D000818:Animals; D004032:Diet; D004195:Disease Models, Animal / Q000139:chemically induced*; D005247:Feeding Behavior; D008297:Male; D010094:Oxonic Acid / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors; D014227:Triazines / Q000494:pharmacology*; D014527:Uric Acid / Q000097:blood* / Q000494:pharmacology
chemical_list: D014227:Triazines; D014527:Uric Acid; D010094:Oxonic Acid