Sustained drug delivery systems. I. The permeability of poly(epsilon-caprolactone), poly(DL-lactic acid), and their copolymers.
The maximum steady state flux, diffusion coefficients, and solubilities of five contraceptive steroids in homopolymers and copolymers of epsilon-caprolactone and DL-lactic acid were determined. The permeabilities of polymers of epsilon-caprolactone were comparable to silicone rubber and, by inference, are suitable for the construction of drug delivery devices. Poly(DL-lactic acid) was 10(4) times less permeable, although its permeability was significantly enhanced by additives.
D003692:Delayed-Action Preparations; D004058:Diffusion; D007773:Lactates / Q000008:administration & dosage*; D007783:Lactones / Q000008:administration & dosage; D008567:Membranes, Artificial; D010539:Permeability; D014677:Pharmaceutical Vehicles; D011091:Polyesters; D011108:Polymers / Q000008:administration & dosage*; D011374:Progesterone; D013739:Testosterone
D003692:Delayed-Action Preparations; D007773:Lactates; D007783:Lactones; D008567:Membranes, Artificial; D014677:Pharmaceutical Vehicles; D011091:Polyesters; D011108:Polymers; C016240:polycaprolactone; D013739:Testosterone; D011374:Progesterone