[Effects of alpha-tocopherol derivatives on natural quinone levels in the tissues of vitamin E deficient rats].
The effects of alpha-tocopherol and its derivatives (alpha-tocopherylquinone, its short-chained analog--alpha-tocopheronolactone--and short-chained alpha-tocopherylacetate) on the levels of ubiquinone, its cyclic isomer--ubichromenol--and vitamin E in the liver and heart of vitamin E-deficient rats were studied. After injection of alpha-tocopherol derivatives the levels of ubichromenol and ubiquinone in rat liver and heart were increased, while their ratio was decreased. alpha-Tocopheronolactone was found to exert the strongest action, which is probably due to its direct effect on ubiquinone metabolism in rat tissues.
D000818:Animals; D006321:Heart / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D011809:Quinones / Q000378:metabolism*; D051381:Rats; D013329:Structure-Activity Relationship; D014810:Vitamin E / Q000378:metabolism / Q000494:pharmacology*; D014811:Vitamin E Deficiency / Q000378:metabolism*
D011809:Quinones; D014810:Vitamin E
Deĭstvie proizvodnykh al'fa-tokoferola na soderzhanie prirodnykh khinonov v tkaniakh vitamin E-nedostatochnykh krys.