Introduction of iron transport by a potent inducer of aryl hydrocarbon hydroxylase, 2, 3, 7, 8--tetrachlorodibenzo-p-dioxin.
A potent enzymatic inducer, 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin, stimulates iron transport in the intestine of the rat. The stimulatory site in the intestine is more available to the inducer given orally than parenterally. Effects on intestinal absorptive mechanisms may be additional public health hazards of enzyme inducers such as 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin.
D000284:Administration, Oral; D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000378:metabolism*; D001693:Biological Transport, Active / Q000187:drug effects; D004147:Dioxins / Q000494:pharmacology*; D004386:Duodenum / Q000378:metabolism*; D004790:Enzyme Induction / Q000187:drug effects; D005982:Glutathione Transferase / Q000378:metabolism; D007274:Injections, Intraperitoneal; D007408:Intestinal Absorption / Q000187:drug effects; D007501:Iron / Q000378:metabolism*; D008099:Liver / Q000201:enzymology; D008297:Male; D000072317:Polychlorinated Dibenzodioxins / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats
D004147:Dioxins; D000072317:Polychlorinated Dibenzodioxins; D007501:Iron; D001189:Aryl Hydrocarbon Hydroxylases; D005982:Glutathione Transferase