[Type A and B monoamine oxidase activity in hyperbaric oxygenation].
Substrate specificity of monoamine oxidase (MAO) of the A type from rat brain and liver tissues was altered after exposure of rats to an increased oxygen pressure [4 ati O2, 1 hr]. Simultaneously with a decrease in monoamine deaminating activity the enzyme acquired an ability to deaminate several substances, which are not MAO substrates in normal state, in particular, aminosugars. Activity of MAO of the B type was not altered in brain under hyperoxia. Alterations in catalytic properties of MAO of the A type were apparently important in development of the oxygen intoxication.
D000818:Animals; D001921:Brain / Q000201:enzymology; D003641:Deamination; D004789:Enzyme Activation / Q000187:drug effects; D006931:Hyperbaric Oxygenation / Q000009:adverse effects*; D008297:Male; D008928:Mitochondria / Q000201:enzymology; D008930:Mitochondria, Liver / Q000201:enzymology; D008995:Monoamine Oxidase / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D010100:Oxygen / Q000633:toxicity; D051381:Rats; D013379:Substrate Specificity / Q000187:drug effects
D008996:Monoamine Oxidase Inhibitors; D008995:Monoamine Oxidase; D010100:Oxygen
Aktivnost' monoaminoksidaz tipov A i B v usloviiakh giperbaricheskoĭ oksigenatsii.