[Effect of precipitating antibodies to pancreatic kallikrein on arginine esterase contact activation in human and rabbit blood].
Effect of precipitating antibodies against pig pancreatic kallikrein on the BAEE-esterase activity was studied in human blood plasma and in rabbit blood serum, activated by kaolin. An inhibitory effect of the antibodies on the increased BAEE-esterase activity was observed within the first minute of incubation after treatment with kaolin. The inhibition of the BAEE-esterase activity constituted 65.1% in human blood plasma and 40.9% in rabbit serum. Possible mechanism is discussed on the inhibition of contact activation of arginine esterase in human and rabbit blood by antibodies against pancreatic kallikrein.
D000818:Animals; D001120:Arginine / Q000276:immunology*; D004789:Enzyme Activation / Q000187:drug effects; D004950:Esterases / Q000097:blood*; D006801:Humans; D007114:Immunization; D066298:In Vitro Techniques; D007610:Kallikreins / Q000276:immunology*; D007616:Kaolin / Q000494:pharmacology; D010179:Pancreas / Q000276:immunology*; D011234:Precipitins / Q000276:immunology*; D011817:Rabbits; D013552:Swine; D013997:Time Factors
D011234:Precipitins; D007616:Kaolin; D001120:Arginine; D004950:Esterases; D007610:Kallikreins
Vliianie pretsipitiruiushchikh antitel k pankreaticheskomu kallikreinu na kontaktnuiu aktivatsiiu argini-ésterazy krovi cheloveka i krolika.