Terbutaline and adrenaline inhibit leakage of fluid and protein in guinea-pig lung.
The effect of terbutaline (0.3 mg/kg s.c.) and adrenaline (0.1 and 0.3 mg/kg s.c.) on histamine--aerosol-induced increase in lung weight and dye content was studied in conscious guinea pigs, previously given Evans blue dye. Both drugs prevented the effects of histamine. It is concluded that terbutaline and adrenaline have a pronounced anti-permeability effect in guinea-pig lungs inhibiting the histamine-induced microvascular efflux of fluid and protein.
D000336:Aerosols; D000818:Animals; D001825:Body Fluid Compartments / Q000187:drug effects*; D001826:Body Fluids / Q000187:drug effects*; D004837:Epinephrine / Q000494:pharmacology*; D005070:Evans Blue; D006168:Guinea Pigs; D006632:Histamine / Q000008:administration & dosage / Q000494:pharmacology; D008168:Lung / Q000187:drug effects / Q000378:metabolism*; D009929:Organ Size / Q000187:drug effects; D011506:Proteins / Q000378:metabolism*; D013726:Terbutaline / Q000494:pharmacology*
D000336:Aerosols; D011506:Proteins; D005070:Evans Blue; D006632:Histamine; D013726:Terbutaline; D004837:Epinephrine