Effects on reflex bladder activity of chemical stimulation of small diameter afferents from skeletal muscle in the cat.
In anesthetized cats selective activation of fine muscle afferents of the hindlimb by KCl or bradykinin (Brad.) induced reflex changes in the urinary bladder. The nature of the reflex responses depended on the functional state of the bladder: they were excitatory when the bladder was quiescent and inhibitory during large, slow, rhythmic micturition contractions. Selective activation of large muscle primary afferents by succinylcholine was ineffective. All reflexes disappeared after cutting the sciatic or the pelvic nerves. Transection of the hypogastric nerves to the bladder had no effect.
D000818:Animals; D001920:Bradykinin / Q000494:pharmacology; D002415:Cats; D006614:Hindlimb / Q000294:innervation*; D009132:Muscles / Q000294:innervation*; D009475:Neurons, Afferent / Q000187:drug effects / Q000502:physiology; D010388:Pelvis / Q000294:innervation; D010525:Peripheral Nerves / Q000502:physiology*; D011189:Potassium Chloride / Q000494:pharmacology; D012018:Reflex / Q000502:physiology*; D012701:Serotonin / Q000494:pharmacology; D001743:Urinary Bladder / Q000294:innervation*; D014554:Urination
D012701:Serotonin; D011189:Potassium Chloride; D001920:Bradykinin