title: [Disturbances in the processes of division and differentiation of the spermatopoietic epithelium in chronic Ramrod poisoning].
abstract: The authors examined histomorphologic changes in the spermatopoietic epithelium in white rats during a chronic a 4-and 6-month intoxication with the herbacide ramrod, used in doses of 1/20, 1/100 and 1/200 of LD50. The authors found that the preparation, known as moderate toxic pesticide, inhibited spermatopoesis at the phase of the formation of spermatids, caused disorganization of seminal epithelium and occurrence of irregular dividing forms. There was dystrophic-degenerativ changes in sex tissue during longer intoxication as well as occurrence of multinuclear gigantic cells. Disturbance in the kynetics of the mitotic division of spermatogonium and blockade of meiosis at its early phases were found as well. The authors assumed that damages in spermatopoiesis were due to distrubed metabolism of the whole organism. An important role was given to the vascular changes, which induced secondary enhancement of the metabolic disturbances in the gonads.
mesh_terms: D000083:Acetanilides / Q000506:poisoning*; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002908:Chronic Disease; D004305:Dose-Response Relationship, Drug; D004848:Epithelium / Q000187:drug effects; D006540:Herbicides / Q000506:poisoning*; D008297:Male; D051381:Rats; D013087:Spermatids / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects*; D013737:Testis / Q000187:drug effects
chemical_list: D000083:Acetanilides; D006540:Herbicides
vernacular_title: Narusheniia v protsesite na delene i differentsirane na spermatopoetichniia epitel pri khronichna intoksikatsiia s ramrod.