title: The synthesis of epsilon-rhodomycinone- and carminomycin-11-methyl ethers.
abstract: The conversion of epsilon-rhodomycinone to its 11-methyl ether via selective hydrolysis of the 4,6,7,11-tetraacetate is described. This series of reactions was used as a model for the conversion of carminomycin to its 11-methyl ether. The anti-tumor activity of the latter compound was less than that of both carminomycin and its 4-methyl ether (daunomycin).
mesh_terms: D000900:Anti-Bacterial Agents / Q000032:analysis / Q000138:chemical synthesis*; D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis*; D002360:Carubicin / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D009682:Magnetic Resonance Spectroscopy; D008745:Methylation; D009279:Naphthacenes / Q000032:analysis / Q000138:chemical synthesis
chemical_list: D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D009279:Naphthacenes; D002360:Carubicin