title: [Studies of intrarenal distribution by macroautoradiogram and tissue distribution of 99mTc-gluconate (author's transl)].
abstract: 1) The experimental studies have demonstrated that 99mTc-gluconate reaches a high concentration in the kidneys within 1-2 hours after injection and its concentration in organs adjacent to the kidney is low. 2) The initial images of serial macroautoradiograms visualized the inner medulla as well as the cortex and outex medulla, whereas the delayed images revealed only the outer cortex and outer stripes in the outer medulla. These findings suggest that this renal agent consists of two components and the delayed component deposits in the convoluted and straight segments of proximal tuble. 3) This renal agent visualizes the calyceal system and excretory pathways in the initial study and the renal morphology in the delayed study. Therefore, using this renal agent, it may be possible to evaluate a variety of renal diseases, including obstructive uropathy, space-occupying lesions, congenital deformities, etc,.
mesh_terms: D000818:Animals; D001345:Autoradiography / Q000379:methods*; D004355:Drug Stability; D005942:Gluconates / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism*; D008297:Male; D051381:Rats; D013667:Technetium; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D005942:Gluconates; D013667:Technetium