Results of eleven years' experience with heated perfusion for melanoma of the extremities.
Eleven years have elapsed since we first added heat to regional perfusion for treatment of melanoma of the extremities. This report describes briefly our laboratory findings and our technique of hyperthermic perfusion and brings up to date the survival figures for the 165 patients (185 perfusions) which were originally reported in 1975 (Stehlin et al., Surg. Gynecol. Obstet., 122: 3--14, 1966). A dramatic increase in the survival rate is documented for those patients with recurrent melanoma confined to the extremities.
D010478:Chemotherapy, Cancer, Regional Perfusion; D005121:Extremities; D006358:Hot Temperature / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007109:Immunity; D008545:Melanoma / Q000276:immunology / Q000628:therapy*; D008558:Melphalan / Q000008:administration & dosage; D009362:Neoplasm Metastasis; D012008:Recurrence; D012878:Skin Neoplasms / Q000276:immunology / Q000628:therapy*
D008558:Melphalan