Theophylline: potentiation of arginine-induced somatostatin release from the isolated rat pancreas.
Somatostatin's release from the isolated rat pancreas was studied using a perfusion technique. Arginine at a concentration of 19 mM produced a biphasic increase in somatostatin release from the perfused rat pancreas. Both first and second phases of somatostatin's increase are significantly higher in the presence of 1 mM theophylline than in the absence of the drug. These results indicate the possible inclusion of the adenylate cyclase--cyclic AMP system in the regulatory mechanism of rat pancreatic somatostatin secretion.
D000818:Animals; D001120:Arginine / Q000494:pharmacology*; D005947:Glucose / Q000494:pharmacology; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D008297:Male; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism*; D010477:Perfusion; D051381:Rats; D013004:Somatostatin / Q000378:metabolism*; D013806:Theophylline / Q000494:pharmacology*
D007328:Insulin; D013004:Somatostatin; D001120:Arginine; D013806:Theophylline; D005947:Glucose