title: [C6-polymorphism of the sixth component of complement: application to paternity cases (author's transl)].
abstract: The results of a study of the polymorphism of the sixth component of human complement by means of isoelectric focusing in polyacrylamide gels with subsequent C-dependent lysis in an agarose overlay containing C6 deficient rabbit serum are reported. The allele frequencies obtained (C6A = 0.613, C6B = 0.379, C6R = 0.008) are in good agreement with those previously published. The mode of inheritance in 47 families with 173 offspring as well as 26 mother-child combinations is in agreement with a formal genetical model: "C6A, C6B, C6A1 and C6B1 at an autosomal locus". The inclusion of this system into a blood group expertise in Germany can be recommended.
mesh_terms: D000328:Adult; D000483:Alleles; D002021:Buffers; D002648:Child; D003183:Complement C6 / Q000032:analysis* / Q000235:genetics; D005260:Female; D006461:Hemolysis; D006801:Humans; D007525:Isoelectric Focusing; D008297:Male; D010334:Paternity; D010641:Phenotype; D011110:Polymorphism, Genetic
chemical_list: D002021:Buffers; D003183:Complement C6
vernacular_title: C6-Polymorphismus der sechsten Komplementkomponente: Ein neues, aussagekräftiges System in der Abstammungsbegutachtung.