Immunity of cholera in man: relative role of antibacterial versus antitoxic immunity.
Purified cholera toxoid is antigenic when given enterally and orally. Purified toxoid fails to provide protection against experimental challenge. Clinical cholera confers formidable protection against homologous or heterologous rechallenge. Failure to culture vibrios from intestinal fluid or stool of re-challenge volunteers suggests that the predominant immune mechanism is antibacterial rather than antitoxic.
D000907:Antibodies, Bacterial / Q000032:analysis; D000992:Antitoxins / Q000032:analysis; D002771:Cholera / Q000276:immunology* / Q000517:prevention & control; D002772:Cholera Toxin / Q000008:administration & dosage / Q000276:immunology; D006801:Humans; D007115:Immunization Schedule; D007136:Immunoglobulins / Q000032:analysis; D007419:Intestinal Secretions / Q000276:immunology; D014734:Vibrio cholerae / Q000276:immunology
D000907:Antibodies, Bacterial; D000992:Antitoxins; D007136:Immunoglobulins; D002772:Cholera Toxin