Effect on core temperature of restraint after peripherally and centrally injected morphine in the Sprague-Dawley rat.
The changes in core temperature (Tc) evoked by morphine in the Sprague-Dawley rate were altered by restraining the rat. The Tc of the free-moving rat rose after the IP (5, 15, 30, 60 mg/kg) or intracerebral injections (10, 20, 50 micrograms) of morphine. In the restrained rate, however, identical doses of morphine evoked either a hyperthermia of lesser magnitude than in the free-moving rat or a drop in Tc. These findings reemphasize the importance of restraint in determinating the action of morphine on Tc and extend the finding to the Sprague-Dawley rat.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D008297:Male; D008845:Microinjections; D009020:Morphine / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D012149:Restraint, Physical; D013997:Time Factors
D009020:Morphine