Antipyrine elimination in critically ill patients.
Antipyrine kinetics were studied in 12 critically ill patients. Antipyrine half life was found to be short (6.5 +/- 3.4 h), this did not alter over 4 days of acute illness, although there was a tendency for antipyrine clearance to decrease over that time period. The need for further pharmacological studies in critically ill patients is stressed.
D000328:Adult; D000983:Antipyrine / Q000378:metabolism* / Q000494:pharmacology; D003422:Critical Care; D005260:Female; D006207:Half-Life; D006801:Humans; D007239:Infections / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D008297:Male; D008875:Middle Aged
D000983:Antipyrine