Histopathology of remodelling induced by PUVA in the superficial dermis.
The histopathological alterations induced by PUVA within the skin are reported in a patient treated for psoriasis. The main impact is located at the site of former psoriatic plaques in which the target is the microvasculature. A residual coating sheath is present around vessels and fibrosis appears in the superficial dermis. These remodellings interfere with the normal dermo--epidermal relationships; the epidermis contains atypical keratinocytes, and melanocytes are no longer recognizable.
D000328:Adult; D001485:Basement Membrane / Q000473:pathology; D004817:Epidermis / Q000473:pathology; D005260:Female; D005363:Ficusin / Q000627:therapeutic use; D006801:Humans; D010778:Photochemotherapy; D011565:Psoriasis / Q000188:drug therapy / Q000473:pathology*; D012867:Skin / Q000473:pathology*
D005363:Ficusin