Ochratoxin A-induced iron deficiency anemia.
Ochratoxin A at 8 micrograms per g of diet, but not at lower doses, fed to chickens from 1 day to 3 weeks of age resulted in significantly (P less than 0.05) decreased packed blood cell volume and hemoglobin concentration without altering the number of circulating erythrocytes. Serum iron and percentage of transferrin saturation were lowered at 4 and 8 micrograms/g. Therefore, anemia was characteristic of severe ochratoxicosis of young chickens, and the anemia was categorized as a hypochromic-microcytic anemia of the iron deficiency type. These data indicate that ochratoxin A by itself does not cause hemorrhagic anemia syndrome of chickens and that an anemia caused by a nutritional deficiency can be elicited by a mycotoxin.
D000747:Anemia, Hypochromic / Q000097:blood / Q000139:chemically induced*; D000818:Animals; D002645:Chickens; D004906:Erythrocyte Count; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D007501:Iron / Q000097:blood; D008297:Male; D009793:Ochratoxins / Q000506:poisoning*; D014168:Transferrin / Q000032:analysis
D006454:Hemoglobins; D009793:Ochratoxins; D014168:Transferrin; D007501:Iron