title: [Histopathology of the kidney in pseudo-Bartter's Syndrome induced by chronic abuse of diuretics (author's transl)].
abstract: A 38-year-old female patient developed a Pseudo-Bartter's-Syndrome with hypokalemic alkalosis, hyponatremia and hyperrenism as the result of the abuse of diuretics (furosemide, spironolactone, thiabutacide) for a period of more than 10 years. The needle biopsy specimen from the kidney showed a hyperplasia of the juxtaglomerular apparatus and of the mesangium cells as the morphologic basis of hyperrenism, a focal vacuolisation of the proximal tubular epithelium and a focal atrophy of the distal tubules. The pathogenesis of the tubular alterations and their possible relation to hypokalemia, hypoxemia or drug-toxicity is discussed, a satisfactory interpretation, however, cannot be given. The encroachment of proximal tubular epithelium on the parietal layer of Bowman's capsule is another striking pathoanatomical finding, and considered a compensatory mechanism under the continuous loss of water.
mesh_terms: D000328:Adult; D001477:Bartter Syndrome / Q000139:chemically induced* / Q000473:pathology; D004232:Diuretics; D005260:Female; D006801:Humans; D006929:Hyperaldosteronism / Q000139:chemically induced*; D007606:Juxtaglomerular Apparatus / Q000473:pathology; D007668:Kidney / Q000473:pathology*; D007684:Kidney Tubules / Q000473:pathology; D019966:Substance-Related Disorders / Q000150:complications*
chemical_list: D004232:Diuretics
vernacular_title: Zur Histopathologie der Niere beim Pseudo-Bartter-Syndrom durch chronischen Diuretikaabusus.