title: Evidence that a factor besides progesterone, prolactin, or plasma-estradiol-binding protein inhibits estrogen-induced sexual receptivity in pregnant rats.
abstract: Daily administration of estradiol benzoate stimulated significantly less lordotic behavior in rats during the second half of pregnancy than in ovariectomized females that received subcutaneous progesterone implants, pituitary grafts that raised plasma prolactin, or both treatments combined. Following an initial facilitation of receptivity, females with progesterone implants showed only moderate reductions in lordosis quotients over 3 test days. The capacity of plasma from pregnant rats to bind estradiol was found to increase significantly during the second half of pregnancy. However, daily administration to pregnant rats of a synthetic estrogen, R 2858, which is not bound by plasma protein, was no more effective than estradiol benzoate in stimulating receptive behavior. Administration of estradiol benzoate also stimulated significantly lower levels of sexual behavior in pregnant females than in females in which pseudopregnancy had been prolonged by previous hysterectomy or induction of uterine decidualization. These findings suggest that some endocrine factor other than progesterone, prolactin, or estradiol-binding protein is primarily responsible for the potent suppression of behavioral responsiveness to estrogen which occurs in pregnant rats. It is suggested that 5 alpha-reduced androgens may cause these behavioral effects.
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000502:physiology; D003656:Decidua / Q000502:physiology; D004958:Estradiol / Q000008:administration & dosage; D045166:Estradiol Congeners / Q000494:pharmacology; D004965:Estrogen Antagonists; D005260:Female; D006728:Hormones / Q000502:physiology*; D011247:Pregnancy; D011270:Pregnancy, Animal; D011374:Progesterone / Q000008:administration & dosage; D011388:Prolactin / Q000008:administration & dosage; D011555:Pseudopregnancy; D051381:Rats; D012726:Sexual Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D013268:Stimulation, Chemical
chemical_list: D002352:Carrier Proteins; D045166:Estradiol Congeners; D004965:Estrogen Antagonists; D006728:Hormones; D011374:Progesterone; D004958:Estradiol; D011388:Prolactin