Controlled drug dissolution by radiation-induced polymerization in the presence of dimethylaminoethyl methacrylate-methyl methacrylate copolymer or methacrylic acid-methyl acrylate copolymer.
Polymer-containing tablet preparation was studied using radiation-induced polymerization of glass-forming monomers at low temperatures in the presence of dimethylaminoethyl methacrylate-methyl methacrylate copolymer or methyl acrylate-methacrylic acid copolymer. Drug dissolution from tablets was in the pH 3.0-8.0 range. A copolymer contained in the tablets dissolved in the dissolution medium at a specific pH. Drug dissolution from tablets took place rapidly at pH greater than 6.0 in the presence of methyl acrylate-methacrylic acid copolymer and at pH less than 5.0 in the presence of dimethylaminoethyl methacrylate-methyl methacrylate copolymer. The polymers had fibrous or capillary pore structures in contrast to the spherical pore structures formed in the presence of polyethylene glycol 600.
D000180:Acrylic Resins / Q000528:radiation effects*; D007700:Kinetics; D008768:Methylmethacrylates / Q000528:radiation effects; D004364:Pharmaceutical Preparations; D011109:Polymethacrylic Acids / Q000528:radiation effects*; D012995:Solubility; D013607:Tablets; D013997:Time Factors
D000180:Acrylic Resins; D008768:Methylmethacrylates; D004364:Pharmaceutical Preparations; D011109:Polymethacrylic Acids; D013607:Tablets