title: Intrarenal renin and autoregulation of renal plasma flow and glomerular filtration rate.
abstract: Autoregulatory responses of renal plasma flow (RPF) and glomerular filtration rate (GFR) to reductions in renal artery pressure (RAP) were studied in both kidneys of two-kidney, one-clamp dogs and in dogs treated with deoxycorticosterone acetate (DOCA; 25 mg/kg) plus high sodium diets with and without renal arterial clamping. In non-DOCA-treated animals, unilateral renal artery constriction resulted in a significant difference (P = 0.004) in renal renin activity (RRA) between the clamped (171 +/- 37 ng AI.mg-1.h-1) and the contralateral (57 +/- 23 mg AI.mg-1.h-1) kidneys with no change in their relative autoregulatory ability. In dogs treated with DOCA/high sodium there were no differences in RRA between the clamped and contralateral kidneys. The dogs treated with DOCA/high sodium were able to autoregulate both RPF and GFR even though their RRA was only 5.4 ng AI.mg-1.h-1. DOCA/high sodium treatment, however, reduced basal RPF (22%) and GFR (23%) below those in non-DOCA-treated animals. Analysis of the autoregulatory ability of individual kidneys showed no relationship to either RRA or renin secretory rates. These results support the conclusion that the renin-angiotensin system is not necessary component in the autoregulation of RPF or GFR.
mesh_terms: D000818:Animals; D001794:Blood Pressure; D003900:Desoxycorticosterone / Q000494:pharmacology; D004032:Diet; D004285:Dogs; D005260:Female; D005919:Glomerular Filtration Rate; D006706:Homeostasis; D007668:Kidney / Q000098:blood supply* / Q000502:physiology; D012039:Regional Blood Flow; D012083:Renin / Q000502:physiology; D012964:Sodium / Q000494:pharmacology
chemical_list: D003900:Desoxycorticosterone; D012964:Sodium; D012083:Renin