title: A fluorescence histochemical study for the motility of the gallbladder.
abstract: For the purpose of elucidating the motility, particularly the mechanism of contraction of the gallbladder, we classified gallbladders isolated surgically into three groups for a study. That is, the three groups comprised Group I of 40 cases of cholelithiasis with good contraction, Group II of 10 cases of cholelithiasis with poor contraction and Group III of 10 cases of cholelithiasis after gastrectomy for a total of 60 cases. Using gallbladders of these cases, we started with a fundamental study on the autonomic nervous action by the fluorescence histochemical method of Flack and Hillarp and obtained results as follows. Similar results were obtained for Group I and Group II; the gallbladder was subjected to adrenergic innervation and cholinergic innervation, and there was a clear localized difference between true-cholinesterase and pseudo-cholinesterase of the cholinergic nerve. In Group III, proliferation of adrenergic nerve was observed compared with Groups I and II, while disappearance of cholinergic nerve was seen. The gallbladder of Group III showed slight contraction with cholecystokinin, but it was not blocked with atropine.
mesh_terms: D001341:Autonomic Nervous System / Q000502:physiology; D002769:Cholelithiasis / Q000503:physiopathology; D002802:Cholinesterases / Q000032:analysis; D005704:Gallbladder / Q000201:enzymology / Q000294:innervation / Q000502:physiology*; D006651:Histocytochemistry; D006801:Humans; D066298:In Vitro Techniques; D009119:Muscle Contraction
chemical_list: D002802:Cholinesterases