Changing patterns of dietary iron overload in black South Africans.
Over the last 17 years there has been a significant reduction in the prevalence and severity of dietary iron overload in urban blacks of Johannesburg. This is attributed to a decrease in the consumption of traditionally brewed beer of high iron content over this period. A 40% reduction was found in hepatic iron concentrations measured in necropsy specimens from 248 male patients who died in 1976 as compared with 220 who died in 1959 and 1960. While hepatic iron concentrations rose with age in both groups there was no evidence of iron accumulation during the period between the two studies. Hepatic iron concentrations measured in 345 female subjects were many fold less than those of males and the 1976 group did not differ significantly from the 1959 to 1960 group. A paradoxical increase in the prevalence of portal fibrosis and cirrhosis was seen and may be due to the effects of increased ingestion of spirits and fortified wine in recent years. Iron overload was significantly greater in males with carcinoma of the esophagus and in those with idiopathic heart failure when compared to subjects who died of other causes. This suggests excessive exposure of these subjects to traditionally brewed beverages and the adulterants present in them.
D000328:Adult; D000368:Aged; D000375:Aging; D000434:Alcoholic Beverages / Q000009:adverse effects* / Q000032:analysis; D000437:Alcoholism / Q000150:complications; D004938:Esophageal Neoplasms / Q000209:etiology; D005260:Female; D006331:Heart Diseases / Q000209:etiology; D006801:Humans; D007501:Iron / Q000032:analysis / Q000378:metabolism / Q000506:poisoning*; D008099:Liver / Q000378:metabolism*; D008103:Liver Cirrhosis / Q000209:etiology; D008107:Liver Diseases / Q000209:etiology; D008297:Male; D008875:Middle Aged; D012806:Siderosis / Q000209:etiology; D013019:South Africa
D007501:Iron