title: [Electron microscopic study of experimental allergic encephalomyelitis in dogs. II. Relationship between ultrastructural changes in the central nervous system and the severity of the course. Mechanism of allergic demyelination].
abstract: It is determined that in grave forms of experimental allergic encephalomyelitis (EAE) demyelination and inflammatory infiltration are spread widely, whereas in easy forms only demyelination is observed. A conclusion is made that disturbances in the vascular permeability, activation of lysosomes and degeneration of synapses are of pathogenic value. Important role of a glia in phagocytizing myelin is emphasized. Significance of the role of immunological humoral factors and of biologic active substances in the pathogenesis of EAE is discussed.
mesh_terms: D000818:Animals; D002199:Capillary Permeability; D002540:Cerebral Cortex / Q000648:ultrastructure; D004285:Dogs; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000473:pathology*; D008297:Male; D008854:Microscopy, Electron; D009186:Myelin Sheath / Q000648:ultrastructure; D009474:Neurons / Q000648:ultrastructure; D013116:Spinal Cord / Q000648:ultrastructure*; D013569:Synapses / Q000648:ultrastructure; D013687:Telencephalon / Q000648:ultrastructure*
vernacular_title: Elektronnomikroskopicheskoe izuchenie éksperimental'nogo allergicheskogo éntsefalomielita u sobak. Soobshchenie II. Osobennosti ul'trastrukturnykh al'teratsii v tsentral'noĭ nervnoĭ sisteme v zavisimosti ot tiazhesti techeniia. Mekhanizm allergicheskoĭ demielinizatsii.