Effect of halogenated benzenes on acetanilide esterase, acetanilide hydroxylase and procaine esterase in rats.
1,2,4-Trichlorobenzene, 1,3,5-trichlorobenzene, hexachlorobenzene, 1,2,4-tribromobenzene, 1,3,5-tribromobenzene and hexabromobenzene were compared for their abilities to induce acetanilide esterase, acentailide hydroxylase and procaine esterase. Except for hexabromobenzene all induced acetanilide esterase whereas the hydroxylation of acetanilide was seen only with the fully halogenated benzenes and with 1,3,5-tribromobenzene. Hepatic procaine esterase activity was increased by the three chlorinated benzenes and 1,2,4-tribromobenzene.
D000083:Acetanilides / Q000378:metabolism*; D000581:Amidohydrolases; D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000378:metabolism*; D001969:Bromobenzenes / Q000494:pharmacology*; D002265:Carboxylic Ester Hydrolases / Q000378:metabolism*; D002722:Chlorobenzenes / Q000494:pharmacology*; D004790:Enzyme Induction / Q000187:drug effects; D004950:Esterases / Q000378:metabolism*; D007536:Isomerism; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D011343:Procaine / Q000378:metabolism*; D051381:Rats
D000083:Acetanilides; D001969:Bromobenzenes; D002722:Chlorobenzenes; D011343:Procaine; D001189:Aryl Hydrocarbon Hydroxylases; D004950:Esterases; D002265:Carboxylic Ester Hydrolases; D000581:Amidohydrolases; C021831:acetanilide esterase