Topical induction of delayed hypersensitivity in the bladder.
Delayed hypersensitivity reactions have been elicited by topical application of dinitrofluorobenzene to the bladder mucosa of sensitized dogs and rats. The resultant animal models may be of value in assessing the role of topically induced delayed hypersensitivity in the attempted immunotherapy of bladder cancer.
D000276:Adjuvants, Immunologic; D000287:Administration, Topical; D000818:Animals; D004139:Dinitrofluorobenzene / Q000008:administration & dosage / Q000276:immunology; D004285:Dogs; D004342:Drug Hypersensitivity / Q000276:immunology* / Q000473:pathology; D006968:Hypersensitivity, Delayed / Q000276:immunology* / Q000473:pathology; D007167:Immunotherapy; D008297:Male; D009092:Mucous Membrane / Q000187:drug effects / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000628:therapy; D009578:Nitrobenzenes / Q000008:administration & dosage / Q000276:immunology; D051381:Rats; D001743:Urinary Bladder / Q000187:drug effects* / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000276:immunology / Q000628:therapy*
D000276:Adjuvants, Immunologic; D009578:Nitrobenzenes; D004139:Dinitrofluorobenzene