Organophosphate pesticide DDVP-induced alterations in the rat cerebellum and spinal cord -- an electron microscopic study.
DDVP is an organophosphate pesticide whose neurotoxicity, in the form of cholinesterase inhbition, is well-known. Rats, weighing 200-225 g were given intraperitoneal injections of 3 mg/kg. DDVP daily for 10 days. Following perfusion-fixation, ultrathin sections of the cerebellum and spinal cord were examined with an electron microscope. A large number of electron-dense bodies exhibiting electron-lucid vacuoles were discernible in the perikarya of cerebellar neurons. Aggregations of mitochondria were also seen. Myelin-figures in dendrites and axons of the spinal cord were detected. Evidence of oedema was evident in the spinal cord.
D000818:Animals; D002531:Cerebellum / Q000648:ultrastructure*; D004006:Dichlorvos / Q000506:poisoning*; D008297:Male; D008928:Mitochondria / Q000648:ultrastructure; D009474:Neurons / Q000648:ultrastructure; D051381:Rats; D013116:Spinal Cord / Q000648:ultrastructure*
D004006:Dichlorvos