[Behaviour of p-nitrophenol-glucuronide in hydrolysis with mineral acids (author's transl)].
The behaviour of p-nitrophenol and synthetic p-nitrophenol-glucuronide with mineral acids has been investigated. With sulfuric acid (33%) about 93% of the glucuronide derivative have been hydrolysed; the solution was heated in open vessel for 15 sec. With hydrochloric acid (6%) only about 65% of the conjugated p-nitrophenol have been converted to the free form. No losses were detected, when free p-nitrophenol was treated under the same conditions. Three other methods of hydrolysis have been applied.
D005965:Glucuronates / Q000494:pharmacology* / Q000652:urine; D006801:Humans; D006851:Hydrochloric Acid / Q000494:pharmacology*; D006868:Hydrolysis; D009596:Nitrophenols / Q000494:pharmacology* / Q000652:urine; D010261:Paraoxon / Q000506:poisoning; D010278:Parathion / Q000506:poisoning; D013464:Sulfuric Acids / Q000494:pharmacology*
D005965:Glucuronates; D009596:Nitrophenols; D013464:Sulfuric Acids; D010278:Parathion; D010261:Paraoxon; D006851:Hydrochloric Acid
Verhalten von p-Nitrophenolglucuronid bei der Spaltung mit Mineralsäuren.