Effect of cimetidine on chronic gastric ulcers produced experimentally in rats.
The authors have studied the effects of cimetidine on the healing of chronic gastric ulcers induced in rats. Gastric ulcers were produced by topical application of 60% acetic acid to the serosal surface of the lesser curvature of the stomach. Oral administration of cimetidine, 150 mg/kg daily, in two divided doses for a maximum of 14 days failed to produce any significant acceleration of healing.
D000085:Acetates; D000284:Administration, Oral; D000818:Animals; D002908:Chronic Disease; D002927:Cimetidine / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D004848:Epithelium / Q000502:physiology; D006146:Guanidines / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D012038:Regeneration / Q000187:drug effects; D013270:Stomach / Q000502:physiology; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology
D000085:Acetates; D006146:Guanidines; D002927:Cimetidine