title: [State of the kallikrein-kinin system in chronic circulatory insufficiency].
abstract: The condition of the kallikrein-kinin system was studied in 93 patients with chronic circulatory insufficiency. In 25 of them it was studied in dynamics--before and after treatment with cardiac glycosides. Marked activation of the kinin system was found in all patients; this was manifested by a decreased level of plasma prekallikrein and phase changes in the content of the kallikrein inhibitor. Improvement in the clinical picture and values of central hemodynamics during treatment was attended by normalization of the main indices of the kinin system. In tolerance of patients to treatment with cardiac glycosides, restoration of the content of the main components of the kinin system was not encountered.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000097:blood*; D002908:Chronic Disease; D003327:Coronary Disease / Q000097:blood; D005260:Female; D006439:Hemodynamics; D006801:Humans; D006973:Hypertension / Q000097:blood; D007610:Kallikreins / Q000037:antagonists & inhibitors / Q000097:blood*; D007705:Kinins / Q000097:blood*; D008171:Lung Diseases / Q000097:blood; D008297:Male; D008875:Middle Aged; D011288:Prekallikrein / Q000097:blood; D012214:Rheumatic Heart Disease / Q000097:blood
chemical_list: D007705:Kinins; D011288:Prekallikrein; D007610:Kallikreins
vernacular_title: Sostoianie kallikrein-kininovoĭ sistemy u bol'nykh s khronicheskoĭ nedostatochnost'iu krovoobrashcheniia.