Cholinergic modulation of anaphylactic dopamine release from calf lung.
Dopamine was released by specific antigen from sensitized calf lung in vitro. Dopamine release was potentiated by carbachol and inhibited by atropine. Nicotine enhanced dopamine release and this action was enhanced by tubocurarine. It is suggested that anaphylactic dopamine release is modulated by a vagal (muscarinic) mechanism in calf lung.
D000707:Anaphylaxis / Q000503:physiopathology*; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002217:Carbachol / Q000494:pharmacology; D002417:Cattle; D004298:Dopamine / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D008168:Lung / Q000378:metabolism*; D008297:Male; D009538:Nicotine / Q000494:pharmacology; D010277:Parasympathomimetics / Q000494:pharmacology*; D014403:Tubocurarine / Q000494:pharmacology
D010277:Parasympathomimetics; D009538:Nicotine; D001285:Atropine; D002217:Carbachol; D004298:Dopamine; D014403:Tubocurarine