Thrombosis following phlebography with ionic and non-ionic contrast media.
The side-effects at phlebography of the lower limb were evaluated using an ionic contrast medium, meglumine-metrizoate, and a non-ionic contrast medium, metrizamide. A post-phlebographic accumulation of 125I-fibrinogen was found in 6 patients examined with meglumine-metrizoate indicating a post-phlebographic thrombosis. Ten patients were examined with metrizamide with no post-phlebographic increase in 125I-fibrinogen uptake. Though the groups are small the difference is statistically significant at the 0.2 per cent level.
D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D007457:Iodine Radioisotopes; D007463:Iodobenzoates / Q000009:adverse effects*; D007866:Leg / Q000098:blood supply; D008536:Meglumine / Q000009:adverse effects*; D008793:Metrizamide / Q000009:adverse effects*; D008794:Metrizoic Acid / Q000009:adverse effects*; D010690:Phlebography / Q000009:adverse effects*; D013012:Sorbitol / Q000031:analogs & derivatives*; D013924:Thrombophlebitis / Q000139:chemically induced* / Q000000981:diagnostic imaging
D007457:Iodine Radioisotopes; D007463:Iodobenzoates; D013012:Sorbitol; D008536:Meglumine; D005340:Fibrinogen; D008794:Metrizoic Acid; D008793:Metrizamide