[Protein-nitrogen metabolism in the liver of rats intraperitoneally administered carminomycin].
It was found in the experiments with rats that in response to carminomycin administration in a single LD50 and the therapeutic doses during the treatment course the intracellular fond of the amino acids in the liver tissue increased, the autolytic processes activated, the activity of the transamination enzymes, histidine and ammonia lyases increased. The level of the residual nitrogen increased mainly at the expense of increased ammonia production and urea levels. These changes were more pronounced when the antibiotic was administered in LD50. Independent of the administration multiplicity and the antibiotic dosage they were of reversible nature and mainly disappeared by the end of the observation.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D001769:Blood / Q000187:drug effects; D002360:Carubicin / Q000008:administration & dosage* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D007274:Injections, Intraperitoneal; D007928:Lethal Dose 50; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D009584:Nitrogen / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D013997:Time Factors
D000903:Antibiotics, Antineoplastic; D011506:Proteins; D002360:Carubicin; D009584:Nitrogen
Belkovo-azotistyĭ metabolizm pecheni krys pri vnutribriushinnom vvedenii karminomitsina.