Disopyramide-induced ventricular fibrillation.
Three cases are described with documented ventricular fibrillation shortly after the patients received disopyramide in moderate dosage. Electrocardiograms showed markedly prolonged Q-T intervals in two patients and a prominent U wave with a prolonged Q-U interval in one patient, but no change in QRS width. Disopyramide-induced ventricular fibrillation appears to be similar to that caused by quinidine and is an indication to discontinue the drug.
D000284:Administration, Oral; D000368:Aged; D001145:Arrhythmias, Cardiac / Q000188:drug therapy*; D004206:Disopyramide / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D004562:Electrocardiography; D005260:Female; D006327:Heart Block / Q000139:chemically induced; D006801:Humans; D008875:Middle Aged; D011725:Pyridines / Q000009:adverse effects*; D013614:Tachycardia, Paroxysmal / Q000139:chemically induced; D014693:Ventricular Fibrillation / Q000139:chemically induced*
D011725:Pyridines; D004206:Disopyramide