title: The effects of vasectomy on testicular metabolism in the guinea-pig.
abstract: The effects of vasectomy on testicular DNA production were studied in guinea-pigs at 2 weeks and 2 and 6 months after surgery. By 6 months, vasectomy had resulted in lower testicular weight and absolute DNA, RNA and protein contents, although RNA and DNA concentrations/protein were unchanged. Incorporation of thymidine into the testis had decreased by 2 weeks after vasectomy, and continued to do so unless the ductal system subsequently ruptured and formed a granuloma when thymidine incorporation returned to normal control levels. It is suggested that in the guinea=pig vasectomy alters spermatogenesis by reducing testicular DNA synthesis.
mesh_terms: D000818:Animals; D004247:DNA / Q000096:biosynthesis*; D006168:Guinea Pigs; D008297:Male; D009929:Organ Size; D011506:Proteins / Q000378:metabolism; D012313:RNA / Q000378:metabolism; D013737:Testis / Q000378:metabolism*; D013936:Thymidine / Q000378:metabolism; D014659:Vasectomy
chemical_list: D011506:Proteins; D012313:RNA; D004247:DNA; D013936:Thymidine