title: Studies on dapsone induced haemolytic anaemia. I. Methaemoglobin production and G-6-PD activity in correlation with dapsone dosage.
abstract: The present study was undertaken on the hypothesis that methaemoglobin production and haemolytic anaemia following dapsone administration could be ascribed to an impairment of glucose-6-phosphate dehydrogenase-enzymatic activity. Analysis of the kinetic parameters of the G-6-PD (Vmax and KM) was performed in ten patients, normal with respect to G-6-PD, suffering from various dermatoses. It was concluded that haemolytic anaemia after dapsone therapy is not due to a functional impairment of the enzyme. The close relationship between dapsone dosage, methaemoglobin production and anaemia make reasonable the hypothesis that a toxic dapsone derivative (DDS-NHOH) could be responsible for the methaemoglobin formation and the haemolytic anaemia.
mesh_terms: D000743:Anemia, Hemolytic / Q000097:blood / Q000139:chemically induced* / Q000201:enzymology; D003622:Dapsone / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D005954:Glucosephosphate Dehydrogenase / Q000097:blood; D006801:Humans; D008708:Methemoglobinemia / Q000139:chemically induced; D012871:Skin Diseases / Q000188:drug therapy
chemical_list: D003622:Dapsone; D005954:Glucosephosphate Dehydrogenase