Rimantadine but not amantadine protects Fischer rat embryo cells from transformation induced by 3-methylcholanthrene or benzo(a)pyrene.
The antiviral drugs amantadine hydrochloride and rimantadine hydrochloride were tested as to their oncogenic potential using a serial line of Fischer rat embryo cells that previously had been shown to be an accurate indicator of chemicals known to be oncogenic in animal studies. Neither compound was found to have transforming activity. At slightly toxic levels, rimanbadine hydrochloride, but not amantadine hydrochloride, protected the same cell line from the transformation induced by the polycyclic hydrocarbons 3-methylcholanthrene and benzo(a)pyrene.
D000218:Adamantane / Q000031:analogs & derivatives / Q000494:pharmacology*; D000547:Amantadine / Q000494:pharmacology*; D000818:Animals; D001580:Benzopyrenes; D001952:Bridged-Ring Compounds / Q000494:pharmacology*; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D008748:Methylcholanthrene; D051381:Rats
D001580:Benzopyrenes; D001952:Bridged-Ring Compounds; D008748:Methylcholanthrene; D000547:Amantadine; D000218:Adamantane