A conformational study of nucleic acid phosphate ester bonds using phosphorus-31 nuclear magnetic resonance.
A systematic phosphorus-31 nuclear magnetic resonance study of some nucleic acid constituents (6-N-(dimethyl)adenylyl-(3',5')-uridine and some nucleotide methyl esters) is presented. The temperature dependent phosphorus-31 chemical shifts were analyzed by standard thermodynamic procedures. It is shown that gt conformations about the P-O ester bonds have a lower free energy content relative to gg conformers.
D000249:Adenosine Monophosphate / Q000031:analogs & derivatives*; D002942:Circular Dichroism; D009682:Magnetic Resonance Spectroscopy; D008433:Mathematics; D008968:Molecular Conformation; D009690:Nucleic Acid Conformation; D009711:Nucleotides; D009943:Organophosphorus Compounds; D013816:Thermodynamics; D014529:Uridine / Q000031:analogs & derivatives
D009711:Nucleotides; D009943:Organophosphorus Compounds; D000249:Adenosine Monophosphate; D014529:Uridine