Activity of antibiotics in contaminated wounds containing clay soil.
Most traumatic wounds are contaminated to some degree by soil and run a high risk of infection. The presence of soil in wounds interferes with natural tissue defenses, which include phagocytosis and serum bactericidal capacity. The experimental studies reported herein clearly demonstrate that soil also limits the antibacterial effects of specific antibiotics. This inactivation appears to be the result of a chemical reaction between the charged antibiotics and the soil particles.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy* / Q000209:etiology; D004285:Dogs; D005839:Gentamicins / Q000627:therapeutic use; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D010406:Penicillins / Q000627:therapeutic use; D012987:Soil; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000209:etiology; D014947:Wounds and Injuries / Q000150:complications / Q000188:drug therapy* / Q000276:immunology
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D010406:Penicillins; D012987:Soil