Ecological effects of antibiotic production by dermatophyte fungi.
Antibiotic production by dermatophyte fungi has been demonstrated in vivo in the lesions of patients with dermatomycoses. Patients infected with antibiotic-producing strains more frequently carried cocci resistant to penicillin and other antibiotics than did patients infected with non-producer strains. The total bacterial load was less in lesions caused by producer fungi. In vitro studies demonstrated the selection of penicillin-resistant S. aureus from mixed populations of resistant and sensitive cells.
D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D001419:Bacteria / Q000254:growth & development*; D003881:Dermatomycoses / Q000382:microbiology*; D004821:Epidermophyton / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D010403:Penicillin Resistance; D012867:Skin / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D014249:Trichophyton / Q000378:metabolism*
D000900:Anti-Bacterial Agents