Methyldopa reaction simulating septic shock.
Though drug fever from methyldopa is well known, to my knowledge fever and hypotension simulating septic shock have never been described in this country as a syndrome resulting from methyldopa therapy. Three such cases are presented here, all proved on rechallenge. They erroneously accounted for almost 6% of all cases of septic shock at St Elizabeth Medical Center in the last ten years.
D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D005334:Fever / Q000139:chemically induced / Q000175:diagnosis; D006801:Humans; D007022:Hypotension / Q000139:chemically induced / Q000175:diagnosis / Q000188:drug therapy; D008750:Methyldopa / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D012772:Shock, Septic / Q000139:chemically induced / Q000175:diagnosis*
D008750:Methyldopa