[Effect of Ca2+ on glucose penetration through the pink ghosts of human erythrocytes].
It has been found that in the presence of millimolar concentrations of calcium added into pink shadows of erythrocytes (C1/2 = 4 mM) the velocity of glucose transport increases three-fold as compared to control shadows. Calcium added from the outside does not affect the glucose transport. Intracellular calcium induces a structural transition in the erythrocyte membrane, which is revealed by spectrin aggregation (electrophoretic data). Study of temperature relationships of glucose transport velocity in the presence of different concentrations of intracellular calcium as well as of the effect of inhibition of transport with phloricin under this condition allows a conclusion that due to Ca-induced transition in the membrane new specialized carriers get involved into glucose transport.
D002118:Calcium / Q000494:pharmacology*; D002352:Carrier Proteins / Q000378:metabolism; D002463:Cell Membrane Permeability / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004910:Erythrocyte Membrane / Q000032:analysis / Q000187:drug effects / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008565:Membrane Proteins / Q000032:analysis; D013696:Temperature
D002352:Carrier Proteins; D008565:Membrane Proteins; D005947:Glucose; D002118:Calcium
Vliianie ionov Ca2+ na proniknovenie gliukozy v rozovye teni éritrotsitov cheloveka.