[The clinical significance of hormone receptors in the treatment of breast cancer].
The assay of steroid receptors in tumor tissue has been shown to be a useful tool to evaluate the response of disseminated breast cancer to endocrine therapy. Principle and problems of this assay are outlined. An objective response of estrogen-receptor positive tumors to endocrine treatment can be achieved in about 60%. The rate of remissions in the receptor-negative group is below 10%. Possible explanations for false-positive or false-negative receptor assays are discussed. Additionally some possibilities for increasing the accuracy of the method are detailed.
D001943:Breast Neoplasms / Q000032:analysis / Q000188:drug therapy*; D005260:Female; D006728:Hormones / Q000627:therapeutic use*; D006801:Humans; D011944:Receptors, Androgen / Q000032:analysis; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D011987:Receptors, Steroid / Q000032:analysis*
D006728:Hormones; D011944:Receptors, Androgen; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D011987:Receptors, Steroid
Die klinische Bedeutung von Hormonrezeptoren bei der Behandlung des Mammakarzinoms.