Intranuclear rodlets in undifferentiated carcinomas of salivary glands in strain A mice in a study involving a tobacco specific nitrosamine, N-nitrosonornicotine.
Undifferentiated carcinomas of the salivary glands were found in 2 of 44 (4.5%) strain A mice injected intraperitoneally with a tobacco specific nitrosamine, N-nitrosonornicotine (NNN). The presence of intranuclear rodlets (INR) in the salivary carcinomas provided the first demonstration of such structures in a non-neuronal tumor in mice. Two types of rodlets were exhibited; one was composed of fibrillar filaments arranged in bundles, and the other was much thicker, branching in form. These INR appeared to be closely associated with nuclear chromatin or nucleoli.
D000818:Animals; D002466:Cell Nucleolus / Q000648:ultrastructure; D002467:Cell Nucleus / Q000648:ultrastructure*; D002843:Chromatin / Q000648:ultrastructure; D005260:Female; D051379:Mice; D008805:Mice, Inbred A; D008854:Microscopy, Electron; D009374:Neoplasms, Experimental / Q000648:ultrastructure; D009538:Nicotine / Q000031:analogs & derivatives*; D009602:Nitrosamines; D010947:Plants, Toxic; D012468:Salivary Gland Neoplasms / Q000139:chemically induced / Q000648:ultrastructure*; D014026:Nicotiana
D002843:Chromatin; D009602:Nitrosamines; D009538:Nicotine