Production of a mutagen from ponceau 3R by a human intestinal anaerobe.
Ponceau 3R was reduced in vitro by Fusobacterium sp. 2, a human intestinal anaerobe, to a product which is mutagenic when metabolically activated by liver S9 preparations in the Salmonella/mammalian-microsome mutagenicity test. This mutagenic metabolite has been identified as 2,4,5-trimethylaniline.
D000814:Aniline Compounds / Q000378:metabolism; D001391:Azo Compounds / Q000378:metabolism*; D004396:Coloring Agents / Q000378:metabolism*; D005673:Fusobacterium / Q000378:metabolism*; D006801:Humans; D007422:Intestines / Q000382:microbiology*; D009153:Mutagens; D010084:Oxidation-Reduction
D000814:Aniline Compounds; D001391:Azo Compounds; D004396:Coloring Agents; D009153:Mutagens; C020478:ponceau 3R