Modifying action of levamisole on the course of adjuvant-induced polyarthritis in rats.
Treatment of August rats with levamisole (L-tetramisole) distinctly depressed the development and the course of adjuvant-induced polarthritis (A-pa). The depressing activity of the drug was dose-dependent. However, spontaneous stimulation of lymphocytes from A-pa rats treated with levamisole was decreased only after the first 7 days of treatment. Moreover, these lymphocytes showed no changes in PHA-reactivity in comparison with untreated animals. It was concluded that levamisole in some circumstances may show immunosuppressive activity; however, it did not seem to act directly on lymphocytes.
D000818:Animals; D001168:Arthritis / Q000188:drug therapy*; D001169:Arthritis, Experimental / Q000188:drug therapy* / Q000276:immunology; D007978:Levamisole / Q000627:therapeutic use*; D008198:Lymph Nodes / Q000276:immunology; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology; D051381:Rats
D007978:Levamisole