[Effect of intracerebroventricular injection of 6-hydroxydopamine and 5,6-dyhydroxytryptamine on the phasic secretion of luteinizing hormone (author's transl)].
In ovariectomized rats carrying an estradiol sylastic implant the effect of the intraventricular administration of the serotonin neurotoxin 5,6-dihydroxytryptamine and of the norepinephrine neurotoxin 6-hydroxydopamine on the circadian secretion of the luteinizing hormone (LH) was studied. The decrease of 5-HT after injection of 5,6-dihydroxytryptamine reduced the a.m. and p.m. values and suppressed the phasic rhythm of LH. The diminution of noradrenaline after administration of 6-hydroxydopamine increased the a.m. and did not alter the p.m. values, resulting in a partial abolition of the rhythm.
D000818:Animals; D001923:Brain Chemistry; D002369:Castration; D002940:Circadian Rhythm / Q000187:drug effects*; D004102:Dihydroxytryptamines / Q000494:pharmacology*; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D006892:Hydroxydopamines / Q000494:pharmacology*; D007986:Luteinizing Hormone / Q000378:metabolism*; D009638:Norepinephrine / Q000032:analysis / Q000378:metabolism; D010053:Ovary / Q000502:physiology* / Q000601:surgery; D051381:Rats; D012636:Secretory Rate / Q000187:drug effects; D012701:Serotonin / Q000032:analysis / Q000378:metabolism; D013268:Stimulation, Chemical
D004102:Dihydroxytryptamines; D006892:Hydroxydopamines; D012701:Serotonin; D004958:Estradiol; D007986:Luteinizing Hormone; D009638:Norepinephrine
Efecto de la inyección intraventricular cerebral de 6-hidroxidopamina y 5-6-dihidroxitriptamina sobre la secreción fásica de hormona luteinizante.