[Interaction of mitogenic lectins with lymphocyte plasma membranes].
It is shown that mitogenic stimuli from concanavalin A and phytohemagglutinin are summed up in the time. Under given experimental conditions each of the mitogens used did not induce mitogenesis when the interaction with lymphocytes continued for 14 and/or 20 hours. The results obtained are discussed from the point of view of the cell-to-cell interaction between the lymphocytes. It is assumed that the ability of the stimuli to sum up in the time underlies the nonspecific mechanism of defense from tolerance.
D000818:Animals; D002462:Cell Membrane / Q000187:drug effects; D003208:Concanavalin A / Q000494:pharmacology; D004247:DNA / Q000378:metabolism; D066298:In Vitro Techniques; D037102:Lectins / Q000494:pharmacology*; D008214:Lymphocytes / Q000187:drug effects* / Q000378:metabolism; D008934:Mitogens; D010835:Phytohemagglutinins / Q000494:pharmacology; D051381:Rats; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors
D037102:Lectins; D008934:Mitogens; D010835:Phytohemagglutinins; D003208:Concanavalin A; D004247:DNA; D013936:Thymidine
Vzaimodeĭstvie mitogennykh lektinov s plazmaticheskimi membranami limfotsitov.