Indomethacin increases abortifacient effect of PGE2 in man.
Results of this study indicate that pretreatment with indomethacin significantly increases the abortifacient effect of an intravenous infusion of PGE2 in patients admitted for abortion as a result of fetal death in utero. Indomethacin pretreatment shortened the duration of PGE2-induced abortion in primigravid and multigravid groups of patients by about 4 and 2 hours respectively. When primigravid and multigravid groups were combined, the dose of PGE2 needed for complete delivery decreases in the indomethacin-treated group by 39.9%.
D000019:Abortifacient Agents; D000028:Abortion, Induced; D000328:Adult; D004357:Drug Synergism; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology*; D007263:Infusions, Parenteral; D010298:Parity; D011247:Pregnancy; D011458:Prostaglandins E / Q000008:administration & dosage; D013997:Time Factors; D014590:Uterine Contraction / Q000187:drug effects
D000019:Abortifacient Agents; D011458:Prostaglandins E; D007213:Indomethacin