[Mutagenic activity of basfungin in its combined action with sodium nitrite].
The mutagenic activity of basfungin, when acting in combination with sodium nitrite, was studied in a subacute experiment, using the method of bone marrow cytogenetic analysis. The results were compared with those in groups in which basfungin and sodium nitrite were applied separately, as well as with the results of the parallel control. The mutagenic effect in the combined action group did not essentially differ from the effect of application of basfungin alone, both qualitatively and diaulitatively. Interesting results were obtained in the group receiving sodium nitrite alone - the percentage of cells with chromosomal aberrations was significantly than the control values.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D002869:Chromosome Aberrations; D004347:Drug Interactions; D005031:Ethylenethiourea / Q000031:analogs & derivatives / Q000494:pharmacology*; D007093:Imidazoles / Q000494:pharmacology*; D007306:Insecticides / Q000494:pharmacology*; D008297:Male; D009153:Mutagens; D009573:Nitrites / Q000494:pharmacology*; D051381:Rats; D012977:Sodium Nitrite / Q000494:pharmacology*; D013859:Thiocarbamates / Q000494:pharmacology*; D013997:Time Factors; D015038:Zineb / Q000031:analogs & derivatives / Q000494:pharmacology*
D007093:Imidazoles; D007306:Insecticides; D009153:Mutagens; D009573:Nitrites; D013859:Thiocarbamates; D005031:Ethylenethiourea; C020222:basfungin; D012977:Sodium Nitrite; D015038:Zineb
Prouchvane na mutagennata aktivnost na basfungin pri kombiniranoto mu deistvie s natriev nitrit.