PBG-synthetase activity in the liver of Yoshida sarcoma-bearing rats.
The etiology of anemia in cancer is not fully understood. A possible cause of the anemia of tumor-bearing animals could be a decreased activity in the enzymes of the heme-pathway. We report the enzyme activity of porphobilinogen-synthetase in the liver of Yoshida sarcoma-bearing rats. PBG-synthetase activity in the whole liver, is higher in tumor-bearing rats than in controls, although the enzyme activity by a gram of wet liver is decreased. Hence PBG-synthetase activity is not a limiting factor in the biosynthesis of heme in tumor-bearing animals.
D000818:Animals; D008099:Liver / Q000201:enzymology*; D008297:Male; D009929:Organ Size; D000623:Porphobilinogen Synthase / Q000378:metabolism*; D051381:Rats; D012517:Sarcoma, Yoshida / Q000201:enzymology*
D000623:Porphobilinogen Synthase