Preliminary observations on the effects of 19-hydroxy prostaglandin E-1 on the activity of the human myometrium in vitro.
The principal prostaglandin of human semen, 19 hydroxy PGE-1, inhibited spontaneous contractile activity of myometrium from non-pregnant women in vitro. This inhibition was similar to that caused by PGE-1. The inhibitory effects of natural 19 hydroxy PGE-1, prepared from semen of Macaca arctoides, were similar to those of synthetic 19 hydroxy PGE-1.
D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D009215:Myometrium / Q000187:drug effects; D011458:Prostaglandins E / Q000494:pharmacology*; D011459:Prostaglandins E, Synthetic / Q000494:pharmacology*; D014590:Uterine Contraction / Q000187:drug effects*
D011458:Prostaglandins E; D011459:Prostaglandins E, Synthetic