title: Pancreatic exocrine secretion in the pig following test meals of different composition and intra-duodenal loads of glucose and maltose.
abstract: Eleven pigs were fitted with pancreatic and duodenal fistulae, and pancreatic juice collected permanently. Amylase, chymotrypsin, lipase and total proteins were determined in juice collected within 2 and 6 hours after different test-meals or intraduodenal loads of glucose and maltose. In the pancreatic juice of pigs adapted to a high-lipid diet and submitted to a high-carbohydrate test-meal the activity of amylase was increased by 50%. When the consumption of the high-lipid meal was associated with an intraduodenal load of 100 g of glucose all the enzyme activities were stimulated when compared to the effect of meal alone, but only the activity of amylase was significantly increased (+ 82%). In the juice of pigs adapted to a balanced diet and submitted to intraduodenal loads of 150 ml of water, 50 g of glucose, 50 g of maltose and 150 g of maltose, the enzyme activities remained almost constant with the load of water and 50 g of maltose but with 50 g of glucose and 150 g of maltose loads, amylase activity was increased by 20% and 30% respectively. It is suggested, that the exocrine pancreas of the pig adapts itself rapidly to the changes in the size of the intestinal pool of starch hydrolysis products.
mesh_terms: D000681:Amylases / Q000378:metabolism; D000818:Animals; D002918:Chymotrypsin / Q000378:metabolism; D004032:Diet; D004386:Duodenum / Q000378:metabolism*; D005947:Glucose / Q000494:pharmacology; D007408:Intestinal Absorption; D008049:Lipase / Q000378:metabolism; D008320:Maltose / Q000494:pharmacology; D010189:Pancreatic Juice / Q000187:drug effects / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism; D013552:Swine
chemical_list: D011506:Proteins; D008320:Maltose; D008049:Lipase; D000681:Amylases; D002918:Chymotrypsin; D005947:Glucose