[Structural and cytochemical characteristics of the heart in the progeny of animals given mercazolyl during pregnancy and lactation].
Morphological and cytochemical features of the heart were studied in ratlings aged 1, 14, 21, 30, and 45 days born of animals which were given mercazolil (3 mg per 1 kg of body weight) during pregnancy and lactation. The relative heart weight of the progeny of the experimental animals proved to be considerably less during the postnatal period under study in comparison with control. A number of structural and cytochemical changes were displayed by the myocardium pointing to its dysfunction.
D000818:Animals; D005260:Female; D005333:Fetus / Q000187:drug effects*; D006321:Heart / Q000187:drug effects*; D007774:Lactation; D008431:Maternal-Fetal Exchange; D008713:Methimazole / Q000633:toxicity*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D009929:Organ Size / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects*; D011247:Pregnancy; D051381:Rats
D008713:Methimazole
Strukturnye i tsitokhimicheskie osobennosti serdtsa u potomstva zhivotnykh, poluchavshikh vo vremia beremennosti i laktatsii merkazolil.