Development of rat telencephalic neurons after prenatal X-irradiation.
Telencephalic neurons of rats, irradiated at day 15 of gestation with 125 R, develop synaptic connections on dendrites during maturation which appear to be normal spines in Golgi-stained light microscope preparations. At six weeks of postnatal age both control and irradiated rats have spiny dendritic processes on cortical pyramidal cells and caudate Golgi type II neurons. However, when the rats are 6 months old the irradiated rats have more neurons with beaded dendritic processes that lack spines or have only a few spines. These neurons resemble the neonatal neurons and are likely to be degenerating neurons. The apparently normal development of the neurons followed by degeneration in the irradiated rat has a parallel in previous reports of the delayed hyperactivity which develops in rats irradiated on the fifteenth gestational day.
D000818:Animals; D002421:Caudate Nucleus / Q000528:radiation effects; D005625:Frontal Lobe / Q000528:radiation effects; D051381:Rats; D013687:Telencephalon / Q000196:embryology / Q000254:growth & development / Q000528:radiation effects*