[Pneumonitis and fibrosis after primary radiotherapy and after combined treatment with chemotherapy in bronchogenic carcinomas].
36 patients with bronchial carcinoma treated in a randomized study were investigated for late reactions of lung tissue after radiotherapy combined with chemotherapy. The onset and extent of the lesions depended on the primary therapy. In the group of patients who received primary chemotherapy the first signs of radiation pneumonitis and fibrosis were seen earlier than in the group who underwent primary radiotherapy (70 days and 120 days respectively, and 170 days and 237 days respectively). The shrinkage of the lung tissue was greater after primary chemotherapy. However, secondary pneumonia in the irradiated lung volume occurred less frequently in the group who underwent chemotherapy first.
D002283:Carcinoma, Bronchogenic / Q000188:drug therapy / Q000532:radiotherapy*; D006801:Humans; D011014:Pneumonia / Q000209:etiology; D011658:Pulmonary Fibrosis / Q000209:etiology*
Pneumonitis und Fibrose nach alleiniger Strahlentherapie und nach kombinierter Behandlung mit Chemotherapie beim Bronchuskarzinom.