Preservation of ischaemically injured canine kidneys with hypertonic citrate solution: the importance of mannitol.
The ability of hypertonic citrate solution to preserve ischaemically injured canine kidneys was investigated. It was found that if mannitol was given i.v. before ischaemia and again after graft revascularization, kidneys subjected to 30 min of warm ischaemia could be preserved for 24 hr, maintaining immediate life-sustaining function.
D000818:Animals; D002951:Citrates / Q000494:pharmacology*; D004285:Dogs; D006358:Hot Temperature; D006982:Hypertonic Solutions; D007511:Ischemia; D007668:Kidney / Q000098:blood supply; D008353:Mannitol / Q000494:pharmacology*; D014021:Tissue Preservation / Q000379:methods*
D002951:Citrates; D006982:Hypertonic Solutions; D008353:Mannitol