Pharmacokinetics of N1-acetyl- and N4-acetylsulphamethoxazole in man.
The pharmacokinetics of N1-acetylsulphamethoxazole and N4-acetylsulphamethoxazole in man are described. N1-Acetylsulphamethoxazole is deacetylated to sulphamethoxazole and acetylated to N4-acetylsulphamethoxazole. N4-Acetylsulphamethoxazole is excreted almost unchanged in the urine. The renal excretion rate is independent of the urine flow and urinary pH. N4-Acetylsulphonamides are less lipid soluble and more acidic than their corresponding parent sulphonamides.
D000107:Acetylation; D000123:Acetyltransferases / Q000378:metabolism; D003404:Creatinine / Q000378:metabolism; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008055:Lipids; D008297:Male; D010641:Phenotype; D012995:Solubility; D013420:Sulfamethoxazole / Q000031:analogs & derivatives* / Q000378:metabolism
D008055:Lipids; D003404:Creatinine; D000123:Acetyltransferases; D013420:Sulfamethoxazole