GABA metabolism in cultured glial cells.
GABA-transaminase has been characterized in cultured astrocytes. It is identical to the synaptosomal and perikaryal enzyme in terms of charge, molecular weight, and stability, but it differs in its affinity for GABA, which is much higher in the glial compartment. GABA-transaminase has been shown to be inducible by high GABA concentrations, which suggests that astrocytes have the possibility not only to transport GABA but also to metabolize the amino acid which is taken up.
D000612:4-Aminobutyrate Transaminase / Q000378:metabolism; D000818:Animals; D001253:Astrocytes / Q000378:metabolism*; D002478:Cells, Cultured; D005910:Glioma / Q000201:enzymology; D051379:Mice; D013574:Synaptosomes / Q000201:enzymology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism* / Q000494:pharmacology
D005680:gamma-Aminobutyric Acid; D000612:4-Aminobutyrate Transaminase