Phototherapy and neonatal liver function.
Two groups of 'healthy' full-term infants with hyperbilirubinemia exposed to phototherapy for 72 h demonstrated no significant change in serum glutamic pyruvic transaminase (SGPT), isocitric dehydrogenase (SICD), alkaline phosphatase (SAP), heat stable alkaline phosphatase (HSAP), total protein and albumin values; these values were similar to those of a comparable group of control infants without hyperbilirubinemia. The bilirubin levels, however, decreased significantly during this period. In a separate group of full-term infants with hyperbilirubinemia, the bromsulphalein (BSP) test before and after 72 h of phototherapy also demonstrated no signficant alteration; the results were comparable to a control group of infants. Phototherapy, even for a duration of 72 h apparently does not seem to affect liver function in infants with hyperbilirubinemia.
D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D001663:Bilirubin / Q000097:blood; D001798:Blood Proteins / Q000032:analysis; D006801:Humans; D007231:Infant, Newborn; D007521:Isocitrate Dehydrogenase / Q000097:blood; D007567:Jaundice, Neonatal / Q000097:blood / Q000503:physiopathology / Q000628:therapy*; D008099:Liver / Q000201:enzymology / Q000378:metabolism / Q000503:physiopathology*; D008111:Liver Function Tests; D010789:Phototherapy; D012709:Serum Albumin / Q000032:analysis
D001798:Blood Proteins; D012709:Serum Albumin; D007521:Isocitrate Dehydrogenase; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D001663:Bilirubin