title: Trans-membrane translocation of proteins. The direct transfer model.
abstract: As a start towards a deeper understanding of the transmembrane transport of proteins, the transfer of a nascent chain through the lipophilic core of a membrane is discussed from a physico-chemical point of view. Some simple considerations of the energetics of protein structure, together with experimental data on the transfer process, form the basis for a detailed and quantifiable model, accounting for the extrusion of secreted proteins as well as for the insertion of trans-membrane proteins.
mesh_terms: D000595:Amino Acid Sequence; D001692:Biological Transport; D008565:Membrane Proteins / Q000378:metabolism; D008566:Membranes / Q000378:metabolism*; D008954:Models, Biological; D011506:Proteins / Q000378:metabolism*; D012270:Ribosomes / Q000378:metabolism
chemical_list: D008565:Membrane Proteins; D011506:Proteins