title: Low-dose chlorambucil in the treatment of generalized granuloma annulare.
abstract: 5 of 6 adults with generalized granuloma annulare responded favorably to therapy with low-dose chlorambucil. 5 of the patients had lesions that were recurrent and long-standing and that resisted conventional modalities of therapy. Low-dose chlorambucil may be effective in a short-term therapy program but should be used only in patients with persistent, widespread, or unusual forms of generalized granuloma annulare. The program requires close patient and hematologic supervision.
mesh_terms: D000368:Aged; D002699:Chlorambucil / Q000008:administration & dosage / Q000627:therapeutic use*; D004341:Drug Evaluation; D005260:Female; D006099:Granuloma / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000473:pathology*; D012871:Skin Diseases / Q000188:drug therapy* / Q000473:pathology
chemical_list: D002699:Chlorambucil