title: The fine structure of stratified ependyma in the ventricular wall of N-ethyl-N-nitrosourea-treated rats.
abstract: Ependymal stratifications, up to 15 cell layers in thickness at the floor of the lateral ventricle of rats treated transplacentally with N-ethyl-N-nitrosourea (ENU), are described. Ultrastructurally the constituent ependymal cells are well-differentiated and show no morphological signs of neoplasia. The possibility that these findings are due to the toxicity or carcinogenicity of ENU is discussed.
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002552:Cerebral Ventricles / Q000648:ultrastructure; D004805:Ependyma / Q000187:drug effects* / Q000648:ultrastructure; D005038:Ethylnitrosourea / Q000494:pharmacology*; D005260:Female; D008431:Maternal-Fetal Exchange; D009607:Nitrosourea Compounds / Q000494:pharmacology*; D011247:Pregnancy; D051381:Rats
chemical_list: D009607:Nitrosourea Compounds; D005038:Ethylnitrosourea