Sensitization of the submaxillary gland of the rat after sympathetic denervation.
The sensitivity of the submaxillary gland of the rat to chemical stimuli was examined 1, 4 and 6 weeks after sympathetic denervation. The gland was found to have developed a supersensitivity not only to noradrenaline but also, in contrast to previous reports, to adrenaline and methacholine. The supersensitivity remained unaltered throughout the period of observation.
D000818:Animals; D003714:Denervation; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D008688:Methacholine Compounds / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D009929:Organ Size; D051381:Rats; D012463:Saliva / Q000378:metabolism; D012636:Secretory Rate / Q000187:drug effects; D013363:Submandibular Gland / Q000187:drug effects / Q000294:innervation / Q000378:metabolism*; D013564:Sympathetic Nervous System / Q000502:physiology*
D008688:Methacholine Compounds; D009638:Norepinephrine; D004837:Epinephrine