title: [Pathomorphology of the brains of schizophrenic patients treated with psychotropic drugs (concerning drug pathomorphosis)].
abstract: Histological methods demonstrated that the use of psychopharmacological drugs in schizophrenic patients does not remove the characteristic neuron pathology (shrinkage, atrophy, lipofuscin dystrophy, cytolysis), but increases the metabolic processes in the intact nervous cells (an increase in the volume and basophilia in the cytoplasma, an enlargement of nuclei and nucleoli) and the glia activity (an increase in the amount of perineuronal satellites, general glia and the glioneuronal index). It is believed that the treatment does not remove the organic brain defect, but stimulates the metabolic processes in the CNS.
mesh_terms: D000328:Adult; D001253:Astrocytes; D001921:Brain / Q000473:pathology*; D002452:Cell Count; D003594:Cytoplasmic Granules; D005260:Female; D006801:Humans; D008062:Lipofuscin; D008297:Male; D008875:Middle Aged; D009457:Neuroglia; D009474:Neurons; D009836:Oligodendroglia; D011619:Psychotropic Drugs / Q000627:therapeutic use*; D012559:Schizophrenia / Q000188:drug therapy* / Q000473:pathology
chemical_list: D008062:Lipofuscin; D011619:Psychotropic Drugs
vernacular_title: Osobennosti patomorfologii golovnogo mozga bol'nykh shizofrenieĭ, lechennykh psikhotropnymi preparatami (k voprosu o lekarstvennom patomorfoze).