Cardiovascular evaluation of obligate heterozygotes in Friedreich's ataxia.
A study of 17 parents (obligate heterozygotes) of children with Friedreich's ataxia was carried out. In addition to medical histories and physical examinations, a standard 12 lead ECG tracing was obtained. In the age group below 50, there was no significant evidence of ischaemic or primary cardiomyopathy. Older subjects had more frequent risk factors for arteriosclerotic heart disease.
D000328:Adult; D002318:Cardiovascular Diseases / Q000150:complications / Q000175:diagnosis*; D003327:Coronary Disease / Q000175:diagnosis; D004569:Electroencephalography; D005260:Female; D005621:Friedreich Ataxia / Q000150:complications / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D006973:Hypertension / Q000150:complications; D008297:Male; D008875:Middle Aged