title: Teratogenic effects of diazepam in the hamster.
abstract: Pregnant hamsters were treated with different doses of oral and intravenous diazepam during the period of organogenesis. Teratogenic effects of diazepam were observed following oral treatment on days 8 and 10 and following intravenous treatment on day 11 of gestation. Types of malformations included cleft palate, exencephaly, limb anomalies, and hemorrhage. A dose-effect relationship was not observed. Comparison with reported literature seems to indicate that diazepam may be a mild teratogen in some species.
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000209:etiology* / Q000473:pathology; D000284:Administration, Oral; D000818:Animals; D006224:Cricetinae; D003975:Diazepam / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007275:Injections, Intravenous; D008647:Mesocricetus / Q000502:physiology; D011247:Pregnancy; D013045:Species Specificity; D013723:Teratogens
chemical_list: D013723:Teratogens; D003975:Diazepam