title: Ocular hypotensive effects of carbonic anhydrase inhibitors in normotensive and glaucomatous Beagles.
abstract: Four carbonic anhydrase inhibitors (acetazolamide, dichlorphenamide, ethoxzolamide, and methazolamide) cause ocular hypotony in normotensive and glaucomatous Beagles. Four dosages of acetazolamide and methazolamide and three dosages of dichlorphenamide and ethoxzolamide were evaluated. The extent of ocular hypotony after these carbonic anhydrase inhibitors was usually greater in glaucomatous Beagles than it was in normotensive Beagles.
mesh_terms: D000086:Acetazolamide / Q000008:administration & dosage / Q000494:pharmacology; D000284:Administration, Oral; D000818:Animals; D002257:Carbonic Anhydrase Inhibitors / Q000494:pharmacology*; D004005:Dichlorphenamide / Q000008:administration & dosage / Q000494:pharmacology; D004283:Dog Diseases / Q000503:physiopathology*; D004285:Dogs / Q000502:physiology*; D005016:Ethoxzolamide / Q000008:administration & dosage / Q000494:pharmacology; D005901:Glaucoma / Q000503:physiopathology / Q000662:veterinary*; D007429:Intraocular Pressure / Q000187:drug effects*; D008704:Methazolamide / Q000008:administration & dosage / Q000494:pharmacology; D013997:Time Factors
chemical_list: D002257:Carbonic Anhydrase Inhibitors; D000086:Acetazolamide; D004005:Dichlorphenamide; D008704:Methazolamide; D005016:Ethoxzolamide