The value of serum alkaline phosphatase alpha 1 isoenzyme in the diagnosis of liver metastases. Preliminary results.
Serum alkaline phosphatase isoenzyme electrophoresis on cellulose acetate plates in a normal population of 91 controls and 255 cancer patients demonstrates the presence of an isoenzyme alpha 1 in 36 out of39 cases of confirmed liver metastases. In 188 cancer patients without apparent hepatic lesion and with a normal liver biology, the alpha 1 isoenzyme has been found in 45 cases, but 11 presented afterwards confirmed liver metastases. This isoenzyme remained negative in the normal population. Therefore, our results indicate that the alpha 1 alkaline phosphatase isoenzyme may be a useful marker for the biological diagnosis of liver metastases.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood*; D004588:Electrophoresis, Cellulose Acetate; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000097:blood*; D008113:Liver Neoplasms / Q000201:enzymology* / Q000556:secondary; D008297:Male; D008875:Middle Aged
D007527:Isoenzymes; D000469:Alkaline Phosphatase