A method for localized and longlasting microapplication of drugs into nervous tissue of freely moving animals.
A method is described for localized microapplication of drugs into nervous tissue of freely moving rats. Fairly constant release of material was observed over a period of more than three weeks. The amount of substance released was small because the rate of release was determined largely by diffusion rather than by mass movement of solution.
D000818:Animals; D001921:Brain / Q000187:drug effects*; D001931:Brain Mapping / Q000295:instrumentation / Q000379:methods*; D003692:Delayed-Action Preparations; D005727:Ganglia, Spinal / Q000187:drug effects; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage*
D003692:Delayed-Action Preparations; D005680:gamma-Aminobutyric Acid