Capillary recruitment during airway hypoxia: role of pulmonary artery pressure.
Hypoxia has been shown to cause an increased number of pulmonary capillaries to be perfused. Changes in cardiac output and left atrial pressure have been previously ruled out as causes of this capillary recruitment. Increased pulmonary vein pressure and increased pulmonary artery pressure remain as two potential mechanisms. To differentiate between these two possible causes, we measured pulmonary artery and vein pressures with directly placed catheters and capillary recruitment with in vivo microscopy. During isocapnic hypoxia pulmonary artery pressure doubled, observed capillary recruitment increased fivefold, and pulmonary vein pressure remained constant. When the vasodilator prostaglandin E1 was infused during hypoxia, pulmonary artery pressure and capillary recruitment fell to control values and pulmonary vein pressure remained constant. Since capillary recruitment correlated with pulmonary artery pressure in each dog, but not with pulmonary vein pressure, we conclude that arterial, not venous, constriction is the probable cause of this recruitment.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002196:Capillaries / Q000502:physiology*; D004285:Dogs; D000860:Hypoxia / Q000503:physiopathology*; D008168:Lung / Q000098:blood supply; D011458:Prostaglandins E / Q000494:pharmacology*; D011651:Pulmonary Artery / Q000502:physiology*; D014666:Vasomotor System / Q000502:physiology
D011458:Prostaglandins E