[Immunocytochemical study of the maturation of the hypothalamo-neuro-hypophysial axes in the human fetus (author's transl)].
1. The development of the hypothalamo-neurohypophysial system was studied using immunocytochemistry with various antisera : anti-neurophysin, anti-oxytocin, anti-vasopressin, anti-vasotocin and anti-somatostatin. 2. Immunocytochemical investigation shows that anti-vasopressin and anti-vasotocin sera react with both vasopressin and vasotocin, whereas the anti-oxytocin serum specifically reveals the oxytocin-containing structures (Fig. 1g, h, i). 3. Perikarya stained with anti-neurophysin, anti-vasopressin and anti-vasotocin sera can be seen from the 11th week of fetal life (Fig. 1a) first in the supra-optic nucleus (SON), then in the para-ventricular nucleus (PVN). Their axons reach the neural lobe as early as the 11th week (Fig. 1b, c). 4. Oxytocin-containing perikarya appear simultaneously in the PVN (Fig. 1e) and SON during the 13th week. 5. From the 16th week, neurons stained with the anti-somatostatin serum can be seen among the neurophysin-positive cell-bodies of the SON and PVN. 6. The various populations of magnocellular neurons show a significant increase in number, especially up to the 19th week, and an increase in their hormonal content up to birth.
D000818:Animals; D002417:Cattle; D005260:Female; D005333:Fetus / Q000502:physiology*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000196:embryology*; D007106:Immune Sera / Q000494:pharmacology; D007231:Infant, Newborn; D009474:Neurons / Q000378:metabolism / Q000502:physiology; D009481:Neurophysins / Q000032:analysis / Q000276:immunology; D011247:Pregnancy; D013004:Somatostatin / Q000032:analysis / Q000276:immunology; D014667:Vasopressins / Q000032:analysis / Q000276:immunology; D014668:Vasotocin / Q000032:analysis / Q000276:immunology
D007106:Immune Sera; D009481:Neurophysins; D014667:Vasopressins; D013004:Somatostatin; D014668:Vasotocin
Etude immunocytologique de la maturation des axes neuroglandulaires hypothalamo-neurohypophysaires chez le foetus humain.