[Effect of armin on the ultrastructure of the neuromuscular synapse].
Alterations induced by the cholinesterase inhibitor armin (5.10(-7) g/ml) in the ultrastructure of motor nerve endings of the rat phrenic diaphragmal preparations at rest or electric stimulation of the nerve were studied. It was shown that armin at rest induced ultrastructural lesions in the endings similar to those in the control preparations during nerve stimulation. Electric stimulation did not produce additional changes in the ultrastructure of the neuromuscular junction under armin action. It is suggested that the disorder of the nerve ending function may be of importance in the mechanism of the blocking action of armin on the neuromuscular transmission.
D000818:Animals; D001138:Armin / Q000494:pharmacology*; D004558:Electric Stimulation; D066298:In Vitro Techniques; D008854:Microscopy, Electron; D009469:Neuromuscular Junction / Q000187:drug effects* / Q000648:ultrastructure; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D051381:Rats; D012146:Rest; D013569:Synapses / Q000187:drug effects* / Q000648:ultrastructure
D009943:Organophosphorus Compounds; D001138:Armin
Vliianie armina na ul'trastrukturu nervno-myshechnogo sinapsa.