Severe hyperkalaemia with Moduretic.
Three patients with impaired renal function suffered complications of hyperkalaemia within 10 days of beginning therapy with hydrochlorothiazide and amiloride combination (Moduretic). The possible relationship between hyperkalaemia and this diuretic is discussed.
D000368:Aged; D000584:Amiloride / Q000008:administration & dosage / Q000009:adverse effects*; D001145:Arrhythmias, Cardiac / Q000209:etiology; D004338:Drug Combinations; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage / Q000009:adverse effects*; D006947:Hyperkalemia / Q000139:chemically induced* / Q000150:complications; D008297:Male; D008875:Middle Aged; D011719:Pyrazines / Q000009:adverse effects*
D004338:Drug Combinations; D011719:Pyrazines; D006852:Hydrochlorothiazide; D000584:Amiloride