A comparison of the cardiovascular responses to carotid injections of ionic and nonionic contrast media.
Selective injection of contrast media into the canine common carotid artery results in alterations in carotid flow, heart rate, and systemic arterial pressure. In this study the responses to injections of the nonionic agents metrizamide and iopamidol were compared to the responses to the ionic agents meglumine iothalamate, meglumine sodium diatrizoate, mannitol, and saline solution. Heart rate and pressure responses were smallest for metrizamide, greater for iopamidol, and greater still for the hypertonic ionic agents: responses were roughly correlated to agent osmolality. Carotid flow increased with all agents and was roughly proportional to the agent's osmolality. The exception was metrizamide which despite its lowest osmolality, produced a large increase in flow which was maintained much longer than for other agents. The total response to the nonionic agents was judged less severe than to the ionic agents; however, the responses to all agents were transient and not life threatening.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001919:Bradycardia / Q000503:physiopathology; D002339:Carotid Arteries; D003326:Coronary Circulation / Q000187:drug effects; D003974:Diatrizoate Meglumine / Q000008:administration & dosage / Q000494:pharmacology; D004285:Dogs; D004562:Electrocardiography; D005260:Female; D006321:Heart / Q000187:drug effects*; D007269:Injections, Intra-Arterial; D007477:Ions; D007482:Iothalamate Meglumine / Q000008:administration & dosage / Q000494:pharmacology; D007483:Iothalamic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D008353:Mannitol / Q000494:pharmacology; D008793:Metrizamide / Q000008:administration & dosage / Q000494:pharmacology; D009994:Osmolar Concentration; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects
D007477:Ions; D007483:Iothalamic Acid; D008353:Mannitol; D003974:Diatrizoate Meglumine; D008793:Metrizamide; D007482:Iothalamate Meglumine