Use of structure-activity relationships to estimate antiallergic activity of 4-hydroxy 3-nitro coumarins.
The antiallergic activity of a series of 4-hydroxy 3-nitro coumarins was studied using Hansch equations and CNDO/2 calculations. Following these calculations a new compound was synthetised which presents an interesting activity.
D015110:4-Hydroxycoumarins / Q000138:chemical synthesis / Q000494:pharmacology*; D000818:Animals; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects*; D011789:Quantum Theory; D051381:Rats; D013329:Structure-Activity Relationship
D015110:4-Hydroxycoumarins