Altered response of cervical and vaginal epithelia to oestradiol benzoate in ewes after prolonged exposure to oestrogenic pasture.
Ovariectomized ewes, 10 clover disease infertility and 10 controls, were injected daily for 3 days with 25 micrograms oestradiol benzoate. At the end of this period, the Spinnbarkeit of cervical mucus and the keratinization of the vaginal epithelium were less in the infertile ewes. It is suggested that the infertility in  clover-affected ewes is due to an inability of target organs to give a continued response to the 'priming' action of oestrogen.
D000818:Animals; D002369:Castration; D002582:Cervix Mucus / Q000187:drug effects / Q000502:physiology*; D004848:Epithelium / Q000187:drug effects / Q000503:physiopathology; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D007247:Infertility, Female / Q000139:chemically induced / Q000503:physiopathology / Q000662:veterinary*; D010937:Plant Growth Regulators / Q000506:poisoning; D012756:Sheep; D012757:Sheep Diseases / Q000139:chemically induced / Q000503:physiopathology*; D014621:Vagina / Q000187:drug effects / Q000503:physiopathology*
D010937:Plant Growth Regulators; D004958:Estradiol