[Regulation of incorporation of amino acids into the thyroid gland proteins by thyroid hormones].
The effect of thyroid hormones and of iodide (1 x 10(-7)M, 5 x 10(-5)M) on the protein synthesis in the cell-free system made of the nodular goiter cells was investigated. As revealed, with the action of thyroid hormones the 14C-amino acids incorporation into the trichloracetic acid-precipitated proteins was considerably diminished. The greatest inhibition of the 14C-amino acids incorporation was observed in toxic (5 x 10(-5)M) hormone concentration. The inhibitory action of triiodthyronine was more expressed than that of thyroxin. Addition of potassium iodide into the incubation medium led to a slight inhibition of the labeled amino acids incorporation. The results obtained permit to regard thyroid hormones as highly specific inhibitors of protein synthesis in the thyroid gland.
D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D002474:Cell-Free System; D002478:Cells, Cultured; D006044:Goiter, Nodular / Q000473:pathology; D006706:Homeostasis; D006728:Hormones / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D051381:Rats; D012269:Ribosomal Proteins / Q000096:biosynthesis*; D012270:Ribosomes / Q000378:metabolism*; D013347:Subcellular Fractions; D013961:Thyroid Gland / Q000473:pathology*; D013974:Thyroxine / Q000494:pharmacology*; D014284:Triiodothyronine / Q000494:pharmacology*
D000596:Amino Acids; D006728:Hormones; D012269:Ribosomal Proteins; D014284:Triiodothyronine; D013974:Thyroxine
Reguliatsiia vkliucheniia aminokislot v belki shchitovidnoĭ zhelezy tireoidnymi gormonami.