The structure of melittin in lipid bilayer membranes.
0.15 M inorganic phosphate dramatically increased the alpha-helix content of melittin in aqueous solution. When melittin interacted with egg yolk phosphatidylcholine liposomes in the absence of inorganic phosphate, it was converted to an alpha-helix rich form, as postulated by Dawson et al. (Dawson, C.R., Drake, A.F. Helliwell, J. and Hider, R.C. (1978) Biochim. Biophys. Acta 510, 75--86).
D001514:Bee Venoms; D002942:Circular Dichroism; D008051:Lipid Bilayers; D008081:Liposomes; D008555:Melitten; D010710:Phosphates; D010713:Phosphatidylcholines; D011487:Protein Conformation
D001514:Bee Venoms; D008051:Lipid Bilayers; D008081:Liposomes; D010710:Phosphates; D010713:Phosphatidylcholines; D008555:Melitten