Renal injury after muscle extract infusion in rats: absence of toxicity with myoglobin.
A crude muscle extract infused into rats produced oliguria, a precipitous drop in total hemolytic complement, and in circulating white cell and platelets counts. A mild vaso-depressor effects was noted. These changes were not produced by myoglobin or saline infusion. Muscle constituents other than myoglobin are responsible for the systemic and renal nephrotoxic effects observed.
D000818:Animals; D001792:Blood Platelets / Q000378:metabolism; D003165:Complement System Proteins / Q000378:metabolism; D003444:Crush Syndrome / Q000209:etiology; D004195:Disease Models, Animal; D007684:Kidney Tubules / Q000187:drug effects*; D007958:Leukocyte Count; D008297:Male; D009124:Muscle Proteins / Q000633:toxicity*; D009211:Myoglobin / Q000633:toxicity; D009846:Oliguria / Q000097:blood / Q000139:chemically induced; D051381:Rats
D009124:Muscle Proteins; D009211:Myoglobin; D003165:Complement System Proteins