The effect of L-DOPA on the ultrastructure of the adenohypophysis of the Chinese quail, Excalfactoria chinensis.
Intraperitoneally injected L-DOPA was found to stimulate strongly the lysosomal system of all of the cell types of the adenohypophysis. We suggest that this amine may play a role in the regulation of the secretory activity of the gland by mediating the lysosomal activity, this role being of variable importance according to the fluctuations in hormonal activity. Utrastructural changes occur in some cell types following injection of L-DOPA. The question as to whether these changes are induced directly by L-DOPA or via the monoaminergic system of the hypothalamus and its hypophysiotropic hormones is discussed.
D000818:Animals; D004295:Dihydroxyphenylalanine / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D007980:Levodopa / Q000494:pharmacology*; D008247:Lysosomes / Q000187:drug effects / Q000502:physiology / Q000648:ultrastructure; D008297:Male; D010903:Pituitary Gland, Anterior / Q000187:drug effects* / Q000648:ultrastructure; D011784:Quail
D007980:Levodopa; D004295:Dihydroxyphenylalanine