Hydrolysis derivatives of (pyridyl-2)acetonitrile.
The alkaline hydrolysis (KOH/EtOH) of alkyl derivatives of (pyridyl-2)acetonitriles gave the corresponding amides. Lactones: 3-(pyridyl-2')3-alkyl-5-methyl-tetrahydrofuran-2-ones were synthesized as result of the hydrolysis of (pyridyl-2) alkylallylacetamides in presence of 85% H3P04. Soporific and anticonvulsive activity exhibited (pyridyl-2)diallylacetic amide 2 and (pyridyl-2)di-n-propylacetamine 3.
D000097:Acetonitriles / Q000032:analysis / Q000494:pharmacology; D000468:Alkalies; D000818:Animals; D000927:Anticonvulsants; D006868:Hydrolysis; D006993:Hypnotics and Sedatives; D007783:Lactones; D051379:Mice
D000097:Acetonitriles; D000468:Alkalies; D000927:Anticonvulsants; D006993:Hypnotics and Sedatives; D007783:Lactones