[Effect of hydrocortisone and insulin on changes of oxidative phosphorylation after neutron irradiation].
Total double irradiation of rats with a fast neutron flow does not affect oxidative phosphorylation in the liver mitochondria but causes an essential decrease in the intensity of phosphorylation in mitochondria and chemoluminescence in blood serum of animals. Postradiation multiple administration of hydrocortisone intensifies the radiation inhibition of oxidation and phosphorylation of mitochondria and insulin administration stimulates phosphorylation in the liver mitochondria and the intensity of chemoluminescence in blood serum of rats. Hydrocortisone in combination with insulin has a less pronounced stimulating effect on phosphorylation than insulin, but the intensity of chemoluminescence in this case is higher than under the effect of each preparation separately.
D000818:Animals; D006854:Hydrocortisone / Q000494:pharmacology*; D007328:Insulin / Q000494:pharmacology*; D049449:Luminescence; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects*; D009502:Neutrons; D010085:Oxidative Phosphorylation / Q000187:drug effects / Q000528:radiation effects*; D010101:Oxygen Consumption / Q000187:drug effects / Q000528:radiation effects; D051381:Rats
D007328:Insulin; D006854:Hydrocortisone
O deĭstvii gidrokortizona i insulina na izmeneniia okislitel'nogo fosforilirovaniia posle neĭtronnogo oblucheniia.