Relationship between insulin and somatotropin in obesity.
The authors have estimated a correlation between the total insulin areas after glucose loading and total somatotropin areas during insulin-induced hypoglycaemia in 30 patients with obesity, as well as in a selected group of 16 patients with simple (essential) obesity. A significant negative correlation was found in both investigated groups. A new hypothesis assuming hyposecretion of somatotropin in obese subjects as a result of hyperinsulinaemia and subsequent increased somatomedin generation is suggested.
D000293:Adolescent; D000328:Adult; D005260:Female; D005947:Glucose; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D007003:Hypoglycemia / Q000097:blood / Q000139:chemically induced; D007328:Insulin / Q000097:blood*; D008875:Middle Aged; D009765:Obesity / Q000097:blood*
D007328:Insulin; D013006:Growth Hormone; D005947:Glucose