Tissue distribution and biochemical properties of an interspecific tumour-associated gamma foetal antigen.
A late-gestation neonatal antigen (gamma foetal antigen; gamma-FA) immunologically and biochemically unrelated to murine alpha-foetoprotein, was identified in several spontaneous and carcinogen-induced sarcomas and hepatic carcinomas of the mouse and rat. An approximate mol. wt of 35,000 for gamma-FA from both foetus and tumour was obtained by molecular-sieve chromatography and sucrose-gradient centrifugation. Radial immunodiffusion analyses of organ extracts indicated that gamma-FA could be found in several neonatal tissues, the highest concentration occurring in the spleen. In the 2-month-old mouse, only splenic tissue contained gamma-FA and at much lower levels than in the organ of the newborn mouse.
D000818:Animals; D000951:Antigens, Neoplasm / Q000032:analysis / Q000276:immunology*; D005260:Female; D005333:Fetus / Q000276:immunology*; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000276:immunology; D051379:Mice; D008970:Molecular Weight; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000276:immunology*; D051381:Rats; D014018:Tissue Distribution
D000951:Antigens, Neoplasm