The effects of aspirin on the development of the mouse third molar. A potential screening system for weak teratogens.
Aspirin is teratogenic at high doses in rodents. A dose related effect is shown at much lower levels in an animal testing system which permits subthreshold effects on development to be measured. This system, which depends on changes in tooth size in the mouse, has advantages in assessing weak or cumulative teratogens.
D000818:Animals; D001241:Aspirin / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D005260:Female; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008963:Molar / Q000187:drug effects* / Q000254:growth & development; D013723:Teratogens
D013723:Teratogens; D001241:Aspirin