Further characterization of fat diet-induced changes in responsiveness to estrogen and glucose.
Possible reasons for hyperresponsiveness to the anorexic influence of estrogen of rats fed a high-fat (F) diet were explored. It was found that (1) hyperresponsiveness appeared unrelated to body weight, (2) other estrogenic effects (upon vaginal epithelia and upon mating behavior) were normal in F-fed rats, (3) hyperresponsiveness to estrogen was not a result of alterations in brain dopamine or norepinephrine, (4) F-fed rats were also hyperresponsive to postabsorptive satiating effects of intragastric glucose loads. Thus, an altered glucose metabolism of F-fed rats may be related to an increased responsiveness to the anorexic effects of estrogen.
D000588:Amines / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000378:metabolism; D002369:Castration; D004041:Dietary Fats / Q000008:administration & dosage*; D004435:Eating / Q000187:drug effects; D002149:Energy Intake / Q000187:drug effects; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D005947:Glucose / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D051381:Rats
D000588:Amines; D001786:Blood Glucose; D004041:Dietary Fats; D007328:Insulin; D004958:Estradiol; D005947:Glucose