[Studies on the effect of 4-methyl-umbelliferon (Hymecromone) in patients following surgical revision of the biliary pathways].
The effect of 4-methylumbelliferone (hymecromone) on postoperative gall volume and residual pressure, serum enzymes, and other parameters in 50 patients after cholecystectomy and choledochotomy with T-tube drainage is measured by a clinical double-blind study. There were several interesting findings: (a) significant less gall flowing from the T tube, (b) highly significant less activity of the enzymes basic phosphatase and of the gamma-glutamyltranspeptidase, and (c) fewer need of analgesics.
D000328:Adult; D000368:Aged; D000700:Analgesics / Q000008:administration & dosage; D001646:Bile / Q000187:drug effects*; D001652:Bile Ducts / Q000601:surgery*; D002763:Cholecystectomy; D003135:Common Bile Duct / Q000601:surgery; D004311:Double-Blind Method; D004322:Drainage; D004798:Enzymes / Q000097:blood; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D006923:Hymecromone / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D010919:Placebos; D011184:Postoperative Period; D014468:Umbelliferones / Q000494:pharmacology*
D000700:Analgesics; D004798:Enzymes; D010919:Placebos; D014468:Umbelliferones; D006923:Hymecromone
Untersuchungen über die Wirkung von-4-Methyl-umbelliferon (Hymecromon) bei Patienten nach operativer Revision der Gallenwege.