Hemodynamic effects of phentolamine in mitral stenosis and congestive cardiomyopahty.
Nine patients with alcoholic cardiomyopathy and 8 patients with mitral stenosis were studied by right and left heart catheterization. Hemodynamic observations were made during control period and during the infusion of phentolamine at a rate of 0.3 mg per minute. The patients with the cardiomyopathy responded to phentolamine with a significant decline in the left ventricular filling pressure, pulmonary artery mean pressure, peripheral resistance, and arteriovenous oxygen difference. There was a significant increase in the cardiac index. The patients with mitral stenosis did not show any hemodynamic improvement after phentolamine infusion.
D002302:Cardiac Output / Q000187:drug effects; D002310:Cardiomyopathy, Alcoholic / Q000188:drug therapy; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D008946:Mitral Valve Stenosis / Q000188:drug therapy*; D010101:Oxygen Consumption / Q000187:drug effects; D010646:Phentolamine / Q000627:therapeutic use*; D014655:Vascular Resistance / Q000187:drug effects
D010646:Phentolamine