[Induction of experimental allergic encephalomyelitis with encephalitogenic myelin proteins from the spinal cord of a bull].
A homogenous base protein, exhibiting high encephalitogenic activity towards guinea pigs and rabbits, was isolated from bovine spinal cord using column chromatography. Administration of the preparation obtained together with Freund's adjuvant into the animals caused development of neurogic symptoms typical for experimental allergic encephalomyelitis as well as formation of demyelinization foci both in spinal cord and in brain of guinea pigs and rabbits.
D000818:Animals; D001921:Brain / Q000187:drug effects; D002417:Cattle; D003711:Demyelinating Diseases / Q000139:chemically induced; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000139:chemically induced*; D005620:Freund's Adjuvant / Q000008:administration & dosage; D006168:Guinea Pigs; D008297:Male; D009185:Myelin Proteins / Q000008:administration & dosage* / Q000302:isolation & purification; D011817:Rabbits; D013116:Spinal Cord / Q000187:drug effects
D009185:Myelin Proteins; D005620:Freund's Adjuvant
Induktsiia éksperimental'nogo allergicheskogo éntsefalomielita éntsefalitogennymi belkami mielina iz spinnogo mozga byka.