Implantation of cigarette smoke condensate in the lungs of Syrian golden hamsters.
Different doses of benzo(a)pyrene, cigarette smoke condensate (CSC) and its nitromethane fraction (NMF), in wax pellets, were directly implanted into the lungs of Syrian golden hamsters. Pleomorphic sarcomas were induced in the B(a)P treated animals. Several epithelial proliferative lesions and a few bronchiogenic adenomas were induced in CSC and NMF treated hamsters. A species-specific effect has been observed in this investigation.
D000236:Adenoma / Q000209:etiology; D000818:Animals; D001580:Benzopyrenes / Q000008:administration & dosage; D006224:Cricetinae; D006965:Hyperplasia; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000209:etiology*; D008297:Male; D008647:Mesocricetus; D008679:Metaplasia; D009374:Neoplasms, Experimental / Q000209:etiology; D012509:Sarcoma / Q000209:etiology; D012907:Smoking / Q000150:complications*; D013045:Species Specificity
D001580:Benzopyrenes