Studies on the mechanism of experimental porphyria produced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine. Role of a porphyrin-like inhibitor of protohaem ferro-lyase.
A green porphyrin-like pigment with inhibitory properties towards protohaem ferro-lyase activity was isolated from the livers of mice and rats after treatment with 3,5-diethoxycarbonyl-1,4-dihydrocollidine. Mice, which are more sensitive to the porphyrogenic properties of the drug, produce more inhibitor. The non-porphyrogenic analogue 3,5-diethoxycarbonylcollidine does not cause accumulation of the pigment in the liver. The inhibitory substance is present in control liver at low but measurable concentrations.
D000818:Animals; D003997:Dicarbethoxydihydrocollidine / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000302:isolation & purification; D006418:Heme; D008099:Liver / Q000378:metabolism; D008190:Lyases / Q000037:antagonists & inhibitors*; D008297:Male; D051379:Mice; D011164:Porphyrias / Q000139:chemically induced / Q000378:metabolism*; D011166:Porphyrins / Q000378:metabolism*; D011725:Pyridines / Q000494:pharmacology*; D051381:Rats
D004791:Enzyme Inhibitors; D011166:Porphyrins; D011725:Pyridines; D006418:Heme; D003997:Dicarbethoxydihydrocollidine; D008190:Lyases