Regeneration of the ureter and the renal pelvis in dogs from transversely transected and anastomosed strips of the ureteral wall. Influence of long administration of azathioprine and prednisone on the newly formed wall. I. Experimental.
Regeneration of the ureter and renal pelvis from a transected and anastomosed strip of the ureteral wall was examined in 20 dogs. The latter were divided into two groups: group A, dogs operated without receiving any drug, and group B, dogs which received 1.5 mg prednisone and 1.5 azathioprine/kg body weight/day before the operation and throughout the postoperative period. Provided the ureteral splint was maintained for at least 28 days, good results were obtained in both groups. Long-term administration of the drugs thus had no adverse effects on the regeneration. Microscopic examination of the newly formed wall, showed more numerous and better arranged muscular fibers and less connective tissues in group B.
D000818:Animals; D001379:Azathioprine / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D007682:Kidney Pelvis / Q000502:physiology* / Q000601:surgery; D011241:Prednisone / Q000494:pharmacology*; D012038:Regeneration / Q000187:drug effects*; D014513:Ureter / Q000166:cytology / Q000502:physiology* / Q000601:surgery; D014546:Urinary Catheterization; D014945:Wound Healing / Q000187:drug effects
D001379:Azathioprine; D011241:Prednisone