The teratogenic activity of a thalidomide analogus EM12 in rats on a low-zinc diet.
The relationship between the teratogenicity of EM12, 2-(2,6-dioxopiperiden-3'-yl) phthalimidine, a stable analogue of thalidomide, and zinc status in the maternal animal was investigated using pregnant rats on a low-zinc diet (1 ppm zinc, days 0--14 gestation) as the experimental model. Previous studies with this compound in rats fed a commercial diet at oral doses up to 250 mg/kg per day for three days and intravenous doses up to 10 mg/kg per day for three days failed to produce "typical" thalidomide malformations. However, when a dose of 150 mg/kg was given intraperitoneally to rats on a low-zinc diet, typical thalidomide malformations occurred with an incidence of 57.5%.
D000014:Abnormalities, Drug-Induced; D000818:Animals; D004032:Diet; D005260:Female; D005552:Forelimb / Q000002:abnormalities; D005865:Gestational Age; D008297:Male; D011247:Pregnancy; D051381:Rats; D012272:Ribs / Q000002:abnormalities; D013792:Thalidomide / Q000031:analogs & derivatives* / Q000633:toxicity; D015032:Zinc / Q000008:administration & dosage / Q000172:deficiency*
D013792:Thalidomide; D015032:Zinc