title: The effect of vasodilatation and sympathetic nerve activation on net water absorption in the cat's small intestine.
abstract: The rate of net water uptake from the feline small intestine has been investigated during control conditions, during graded infusions of the vasodilator drug isopropylnoradrenaline, and during electrical stimulation of the regional sympathetic nerve fibres to the gut. Net water absorption rate was largely unaffected by intestinal vasodilatation. The fraction of the absorbate transported via the lymphatics remained also constrant at 20-40% of the total absorption regardless of blood flow rate. Stimulating the sympathetic nerve fibres to the small intestine increased, however, net water absorption rate. The increase was particularly pronounced when blood pressure was kept constant during the period of stimulation. The absorption rate was on an average almost doubled at a stimulation frequency of 8 Hz during constant pressure conditions. The mechanism(s) explaining this nervous control of water absorption are tentatively discussed.
mesh_terms: D000320:Adrenergic Fibers / Q000502:physiology*; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001834:Body Water / Q000378:metabolism*; D002415:Cats; D004558:Electric Stimulation; D007408:Intestinal Absorption / Q000187:drug effects; D007421:Intestine, Small / Q000098:blood supply / Q000294:innervation / Q000378:metabolism*; D009638:Norepinephrine / Q000031:analogs & derivatives / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011941:Receptors, Adrenergic / Q000187:drug effects; D013566:Sympathomimetics / Q000494:pharmacology*; D014664:Vasodilation
chemical_list: D011941:Receptors, Adrenergic; D013566:Sympathomimetics; D001285:Atropine; D011433:Propranolol; D009638:Norepinephrine; D010646:Phentolamine