Multicompartment pharmacokinetic analysis and simulations using a programmable calculator.
This paper describes the use of a programmable calculator (HP-97), for fitting plasma concentration profiles to 1 and 2 compartment open models and calculating fitted and derived parameters together with estimates of steady state plasma drug levels following various dosage regimens in clinical settings.
D003201:Computers; D004334:Drug Administration Schedule; D004358:Drug Therapy; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000097:blood* / Q000378:metabolism
D004364:Pharmaceutical Preparations