[Clinico-physiological sleep- and hangover-spectra from pentobarbital, promazin and their combination, as reflected by self-ratings of young and elderly subjects (author's transl)].
A sample of 8 young and 8 elderly subjects was examined in a 2x2x2 factorial design, whether and how promazine interacts with pentobarbital as a hypnotic agent. Analyses of self-reports led to the following conclusions: 1. Young subjects and not experience any significant effects from either the single components (pentobarbital, promazine) and/or their combination. 2. Elderly subjects experienced positive effects in sleep and hangover parameters under the single components as well as under the combination. Consequences for research in clincal psychopharmacology are discussed.
D000328:Adult; D000368:Aged; D000375:Aging; D004338:Drug Combinations; D006801:Humans; D010424:Pentobarbital / Q000009:adverse effects / Q000494:pharmacology*; D011395:Promazine / Q000009:adverse effects / Q000494:pharmacology*; D012890:Sleep / Q000187:drug effects*
D004338:Drug Combinations; D010424:Pentobarbital; D011395:Promazine
Klinisch-psychologische Schlaf- und Nachwirkungs-spektren von Pentobarbital, Promazin und ihrer Kombination im Spiegel der Selbstbeurteilung junger und alter Versuchspersonen.