[High doses of thiopental for therapy of post-ischaemic anoxia of the brain. A case report (author's transl)].
The case of a 7-year-old child is presented, who suffered circulatory arrest during induction of anaesthesia for surgery for a posterior fossa tumour. A brain ischaemia lasting 6 minutes duration had to be assumed. After restoration of circulation, 825 mg ethiopenta were administered in order to ameliorate a possible post-ischaemic anoxia of the brain according to a protocol by Safar [18]. 11 hours after circulatory arrest the child awoke. Except for a more pronounced left sided hemiparesis and paresis of the left n. abducens no additional neurological deficit was observed compared to the neurological status before induction of anaesthesia.
D000758:Anesthesia / Q000009:adverse effects; D002528:Cerebellar Neoplasms / Q000601:surgery; D002648:Child; D004305:Dose-Response Relationship, Drug; D005260:Female; D005910:Glioma / Q000601:surgery; D006323:Heart Arrest / Q000209:etiology; D006336:Heart Massage; D006429:Hemiplegia / Q000209:etiology; D006801:Humans; D002534:Hypoxia, Brain / Q000188:drug therapy*; D013874:Thiopental / Q000627:therapeutic use*
D013874:Thiopental
Hochdosierte Thiopentalgabe zur Therapie der postischaemischen Anoxie des Gehirns.