[Selective inhibition of the primary humoral immune response in mice with a combination of deoxycytidine with Cytosar].
Cytosine arabinoside administration in lethal doses to C57BL/6j female mice immunized with red blood cells leads, under deoxycytidine protection, to reduction of serum hemagglutinin level on day 5 without toxicosis. Simultaneous injection of the metabolite and the antimetabolite proves to be optimum.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D003561:Cytarabine / Q000276:immunology*; D003841:Deoxycytidine / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D004338:Drug Combinations; D005260:Female; D006388:Hemagglutinins / Q000032:analysis; D007114:Immunization; D007166:Immunosuppressive Agents; D008433:Mathematics; D051379:Mice; D008810:Mice, Inbred C57BL
D004338:Drug Combinations; D006388:Hemagglutinins; D007166:Immunosuppressive Agents; D003561:Cytarabine; D003841:Deoxycytidine
Izbiratel'noe ugnetenie pervichnogo gumoral'nogo immunnogo otveta u mysheĭ kombinatsieĭ dezoksitsitidina s tsitozarom.