Studies on a subcellular system for vitamin K-dependent carboxylation.
The subcellular localization of acarboxyprothrombin and the vitamin K-dependent carboxylation system has been studied using livers from vitamin K-deficient rats and found to be mainly in the membranes of the rough microsomal fraction. Bovine acarboxyprothrombin or fragment 1 thereof were inactive as substrates in the rat carboxylating system.
D000818:Animals; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism*; D011516:Prothrombin / Q000031:analogs & derivatives*; D051381:Rats; D012910:Snake Venoms; D014813:Vitamin K Deficiency / Q000378:metabolism*
D012910:Snake Venoms; D011516:Prothrombin