Antihypertensive activity of some novel pyridinylidene arylurea derivatives in spontaneously hypertensive rats.
3 novel pyridinylidene arylurea derivatives were found to lower arterial pressure in spontaneously hypertensive rats. Their relative oral potency ranged from 6 to 32 times that of guanethidine. The onset of antihypertensive action following their oral administration was less than 1 h and the duration of action ranged from 8 to over 24 h. The antihypertensive activity of the pyridinylidene arylureas was found to be assoicated with depletion of tissue catecholamines. Compound C depleted cardiac norepinephrine with little or no effect on total brain norepinephrine levels. It is suggested that compound C may have useful antihypertensive properties without CNS depressant activity.
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology / Q000633:toxicity; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000378:metabolism; D002395:Catecholamines / Q000378:metabolism; D002415:Cats; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism; D010671:Phenylurea Compounds / Q000494:pharmacology* / Q000633:toxicity; D011725:Pyridines / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D013329:Structure-Activity Relationship
D000959:Antihypertensive Agents; D002395:Catecholamines; D010671:Phenylurea Compounds; D011725:Pyridines