[Relationship between the magnitude of the inflowing current of isolated Limnea stagnalis mollusk neurons and the external concentration of the current-bearing calcium and strontium ions].
The dose-inward current relationships for current-carrying ions Ca2+ and Sr2+ were studied by means of intracellular dialysis and voltage clamp in isolated neurons of the mollusc Limnea stagnalis. For Ca2+ and Sr2+ ions these relationships had ceiling. The data obtained are explained in terms of activation theory using two-barrier model of calcium channel. Values of velocity constants vx for ion x2+ transition over the second energetic barrier and of constants Kx corresponding to effectiveness of binding in the channel's entrance were determined: vca:vsr = 1:2; KCa = 1400 M-1; KSr = 270 M-1.
D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D002463:Cell Membrane Permeability / Q000187:drug effects; D004058:Diffusion; D007473:Ion Channels / Q000187:drug effects* / Q000502:physiology; D008195:Lymnaea / Q000502:physiology; D008564:Membrane Potentials / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D013324:Strontium / Q000494:pharmacology*
D007473:Ion Channels; D002118:Calcium; D013324:Strontium
Izuchenie zavisimosti velichiny vkhodiashchago toka izolirovannykh neĭronov molliuska Limnea stagnalis ot naruzhnoĭ kontsentratsii tokoperenosiashchikh ionov kal'tsiia i strontsiia.