Side-effects of mixed agonist-antagonist analgesics used in sequential anaesthesia.
1 Mixed agonist-antagonist analgesics have analgesic action but also possess a range of side-effects. 2 Narcotic antagonists do not reverse the non-specific effects of opiates. 3 Under certain circumstances the effects of agonists and mixed agonist-antagonists can be additive. 4 Chronic dosage of mixed agonist-antagonists leads to a lower level of dependence than that observed with the standard narcotics. 5 Mixed agonist-antagonists may not antagonize the respiratory effects of narcotics and may result in potentiation of such depression.
D000758:Anesthesia; D002320:Cardiovascular Physiological Phenomena; D006801:Humans; D009292:Narcotic Antagonists / Q000009:adverse effects*; D009294:Narcotics / Q000009:adverse effects*
D009292:Narcotic Antagonists; D009294:Narcotics