Antineoplastic activity and cytotoxicity of flavones, isoflavones, and flavanones.
Several hundred flavonoid derivatives, natural and synthetic, which have been tested in the screening program of the National Cancer Institute, have been examined for indications of structure-activity relationships which might exist among these compounds. No such relationships are apparent. In spite of occasional activity these compounds do not warrant further detailed pursuit as anti-tumor agents.
D000818:Animals; D000970:Antineoplastic Agents; D005419:Flavonoids / Q000494:pharmacology*; D006801:Humans; D007529:Isoflavones / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D005419:Flavonoids; D007529:Isoflavones