title: [Hematic radio-immunologic monitoring of clonazepam: clinical-pharmacological evaluations in a group of epileptic patients].
abstract: In a group of 22 epileptic patients under treatment with clonazepam (CNP) it has been evaluated the serum levels of CNP in a seried way for a period of several months, by a radio-immunological technique. Except for one patient, all the others were under politherapy. On the basis of the data obtained from this study we tried to evaluate the pharmachological action of CNP. Even if we found a good clinical efficacy of CNP with therapeutic ranges (from 19,57 +/- 10,98 ng/ml up to 60,16 +/- 31,18 ng/ml) we didn't find any correlation between the oral dose and serum level, taking into account also other parameters such as sex, pound and age. The Authors discuss the possible factors which may be thought involved in this lacking correlation.
mesh_terms: D000293:Adolescent; D000328:Adult; D001570:Benzodiazepinones / Q000097:blood*; D002648:Child; D002998:Clonazepam / Q000097:blood* / Q000627:therapeutic use; D004827:Epilepsy / Q000097:blood / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D011863:Radioimmunoassay; D013226:Status Epilepticus / Q000188:drug therapy
chemical_list: D001570:Benzodiazepinones; D002998:Clonazepam
vernacular_title: Monitoraggio ematico radio-immunologico del clonazepam: valutazioni cliniche farmacologiche in un gruppo di pazienti epilettici.