[Progressive dialytic encephalopathy. Role of the aluminium and neurological study. One case (author's transl)].
Report a typical case of dialytic dementia in a patient treated with aluminium gels. The course was fatal in fifteen months duration. Before interruption of aluminium gel intake, the aluminium blood level measured by atomic absorption spectrography was at 1300 microgram/l (normal less than 40 microgram/l). Cerebral aluminium was studied by the method of Le Gendre and Alfrey. On the three studied specimens of gray matter including, the parieto rolandic cortex, the thalamus, the cerebellar cortex, the mean aluminium concentration was seven times higher than the witness. The optic and electronic microscopy study showed important accumulation of lipofuscin. No neurofibrillary degeneration was observed. In contrast to the intensity of the clinical signs and the fatal course the cerebral lesions were slight.
D000535:Aluminum / Q000009:adverse effects* / Q000032:analysis / Q000097:blood; D001921:Brain / Q000473:pathology / Q000648:ultrastructure; D001923:Brain Chemistry; D001927:Brain Diseases / Q000139:chemically induced / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D002525:Cerebellar Cortex / Q000032:analysis; D002540:Cerebral Cortex / Q000032:analysis; D005260:Female; D006801:Humans; D008062:Lipofuscin / Q000032:analysis; D008875:Middle Aged; D006435:Renal Dialysis / Q000009:adverse effects*; D013788:Thalamus / Q000032:analysis; D013997:Time Factors
D008062:Lipofuscin; D000535:Aluminum
Encéphalopathie progressive des dialysés: rôle de l'aluminium et étude neuropathologique. Une observation.