The influence of phthalate esters on human plasma lecithin/cholesterol acyltransferase.
The effect of various phthalate esters on the lecithin/cholesterol acyltransferase activity in man was studied in vitro. The enzymatic activity was strongly reduced with all phthalates except for the dimethyl phthalate. The inhibition rate depends on the phthalate concentration and also on the carbon number of the alkyl groups of phthalates.
D000217:Acyltransferases / Q000097:blood*; D003993:Dibutyl Phthalate / Q000494:pharmacology; D004051:Diethylhexyl Phthalate / Q000494:pharmacology; D006801:Humans; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000037:antagonists & inhibitors / Q000097:blood*; D010795:Phthalic Acids / Q000494:pharmacology*; D002785:Sterol O-Acyltransferase / Q000037:antagonists & inhibitors / Q000097:blood*
D010795:Phthalic Acids; D003993:Dibutyl Phthalate; D004051:Diethylhexyl Phthalate; D000217:Acyltransferases; D002785:Sterol O-Acyltransferase; D007862:Phosphatidylcholine-Sterol O-Acyltransferase