Pharmacological protection of rabbit kidneys from normothermic ischemia.
This study investigated the influence of the administration of pharmacological agents on the recovery of rabbit kidneys from the effects of 1 hr of situ normothermic ischemia, utilizing acute and chronic models. The agents tested included the diuretics mannitol and furosemide, the vasoactive agents phenoxybenzamine, propranolol, and dopamine, and the membrane stabilizers chlorpromazine and methylprednisolone. A beneficial effect was detected only with the diuretic agents and propranolol when given prior to the ischemic insult.
D000818:Animals; D001831:Body Temperature; D002746:Chlorpromazine / Q000627:therapeutic use; D004298:Dopamine / Q000627:therapeutic use; D005260:Female; D005665:Furosemide / Q000627:therapeutic use; D007511:Ischemia / Q000188:drug therapy*; D007668:Kidney / Q000098:blood supply* / Q000503:physiopathology; D008297:Male; D008353:Mannitol / Q000627:therapeutic use; D008775:Methylprednisolone / Q000627:therapeutic use; D010643:Phenoxybenzamine / Q000627:therapeutic use; D011433:Propranolol / Q000627:therapeutic use; D011817:Rabbits
D010643:Phenoxybenzamine; D008353:Mannitol; D005665:Furosemide; D011433:Propranolol; D002746:Chlorpromazine; D004298:Dopamine; D008775:Methylprednisolone