Relative contributions of diet and sunlight to vitamin D state in the elderly.
In winter the vitamin D state of elderly people may reach levels associated with osteomalacia, although the disease may not be clinically apparent. A statistical correlation was observed in a group of elderly subjects during the winter between dietary vitamin D intake and vitamin D state, but the intake was generally too low to make a biologically important contribution to maintaining vitamin D concentrations. Ultraviolet light (UVL) is the primary determinant of vitamin D state in summer and winter, in winter owing to the pools of vitamin D built up during the previous summer. Plasma concentrations of 25-hydroxy vitamin D (25-OHD) in winter of 15.0-22.5 nmol/l (6-9 ng/ml) require that the concentration in the previous summer was over 40 nmol/l (16 ng/ml). To maintain plasma concentrations in the elderly above those associated with osteomalacia a mean dietary vitamin D intake of over 5 microgram/day is required. A more physiological approach, however, would be to increase exposure to UVL.
D000368:Aged; D004032:Diet; D005260:Female; D006801:Humans; D006887:Hydroxycholecalciferols / Q000097:blood; D008297:Male; D012621:Seasons; D013472:Sunlight; D014807:Vitamin D / Q000378:metabolism*
D006887:Hydroxycholecalciferols; D014807:Vitamin D