Dependence on the lipophilicity of maleimide derivatives in their inhibitory action upon chemotaxis in neutrophils.
Modification of polymorphonuclear neutrophils by a series of maleimide derivatives with various degrees of lipophilicity and hydrophilicity indicated that hydrophilic reagents had little effect on chemotaxis, whereas the degree of the inhibitory effect of lipophilic reagents on the chemotaxis was parallel to the degree of their lipophilicity.
D000818:Animals; D002633:Chemotaxis / Q000187:drug effects*; D006168:Guinea Pigs; D008301:Maleimides / Q000494:pharmacology*; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology*; D013329:Structure-Activity Relationship
D008301:Maleimides