Changes in the activities of protein kinase modulators in the cerebellum of mice due to ethanol, caffeine, or phenobarbital administration.
Decreased activities of both the inhibitory modulator of adenosine 3':5'-monophosphate (cAMP)-dependent protein kinase (A-PK) as well as the stimulatory modulator of guanosine 3':5'-monophosphate (cGMP)-dependent protein kinase (G-PK) from the mouse cerebellum were noted due to the administration of excessive doses of ethanol, caffeine, and phenobarbital for up to 28 days. The dose-dependent of the inhibition of A-PK or the stimulation of G-PK was observed as a function of the amount of protein kinase modulators in the cerebellum of mice receiving different doses of ethanol.
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology; D002110:Caffeine / Q000494:pharmacology*; D002531:Cerebellum / Q000187:drug effects / Q000201:enzymology*; D004789:Enzyme Activation; D000431:Ethanol / Q000494:pharmacology*; D007700:Kinetics; D051379:Mice; D009419:Nerve Tissue Proteins / Q000502:physiology*; D010634:Phenobarbital / Q000494:pharmacology*; D011494:Protein Kinases / Q000378:metabolism*
D009419:Nerve Tissue Proteins; D002110:Caffeine; D000431:Ethanol; D011494:Protein Kinases; D001205:Ascorbic Acid; D010634:Phenobarbital