Enhancement of carcinoembryonic antigen expression by interferon.
Human interferon decreased DNA but not RNA synthesis in a human colon carcinoma cell line, WiDr; in addition, there was a two- to three-fold increase in the expression of a tumor-associated antigen, carcinoembryonic antigen. In contrast, interferon had no effect on a normal human diploid cell line, WI-38. Thus, in addition to its anti-cellular effect against tumor cells, interferon can also modulate tumor antigenicity.
D002272:Carcinoembryonic Antigen / Q000032:analysis / Q000378:metabolism*; D002277:Carcinoma / Q000276:immunology* / Q000378:metabolism / Q000628:therapy; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D003110:Colonic Neoplasms / Q000276:immunology* / Q000378:metabolism / Q000628:therapy; D004273:DNA, Neoplasm / Q000096:biosynthesis; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D007372:Interferons / Q000494:pharmacology* / Q000627:therapeutic use; D012334:RNA, Neoplasm / Q000096:biosynthesis
D002272:Carcinoembryonic Antigen; D004273:DNA, Neoplasm; D012334:RNA, Neoplasm; D007372:Interferons