Determination of prostaglandin F2 alpha, E2, D2 and 6-keto-F1 alpha in human cerebrospinal fluid.
Prostaglandin (PG)F2 alpha, E2, D2 and 6-keto-F1 ALha were determined in human cerebrospinal fluid by a mass spectrometric technique. The samples were obtained from 12 patients with suspected intracranial disease. A 64 fold variation in PG levels was observed. The major PG was 6-keto-F1 alpha (0.12--15 ng/ml). PGF2 alpha and PGE2 were present in lower concentrations PGD2 was below the level of detection (0.05 ng/ml) except in one patient with extremely high total levels of PGs.
D000328:Adult; D000368:Aged; D001927:Brain Diseases / Q000134:cerebrospinal fluid; D001932:Brain Neoplasms / Q000134:cerebrospinal fluid; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D013058:Mass Spectrometry; D008875:Middle Aged; D011453:Prostaglandins / Q000134:cerebrospinal fluid*; D011457:Prostaglandins D / Q000134:cerebrospinal fluid*; D011458:Prostaglandins E / Q000134:cerebrospinal fluid*; D011460:Prostaglandins F / Q000134:cerebrospinal fluid*
D011453:Prostaglandins; D011457:Prostaglandins D; D011458:Prostaglandins E; D011460:Prostaglandins F