title: [Effect of preoperative paromomycin therapy on the course of wound healing after colonic intervention. A prospective blind study].
abstract: 156 patients undersent colorectal surgery during a prospective blind study at the Städt. Krankenhaus München-Harlaching. The study showed that administration of 4,0 g Paromomycin (= Humatin) on each of the two preoperative days combined with mechanical cleansing of the intestine has a beneficial effect. Our test group showed significantly lower incidence of wound complications at the abdominal laparotomies (p less than 0,05; X2) and at the anastomoses (p less than 0,01; X2 than the control group. Anastomic leakage (major leaks) and following septical complications occurred nearly exclusively in our "Not-Humatin-group". The lethality of the entire group was 13,1% (n = 20).
mesh_terms: D000368:Aged; D001424:Bacterial Infections / Q000517:prevention & control; D003106:Colon / Q000601:surgery*; D003125:Colostomy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010303:Paromomycin / Q000627:therapeutic use*; D011446:Prospective Studies; D012003:Rectal Fistula / Q000601:surgery; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D010303:Paromomycin
vernacular_title: Der Einfluss präoperativer Paromomycin-Therapie auf den Wundheilungsverlauf nach Eingriffen am Dickdarm. Eine prospektive Blindstudie.