title: [Changes in the kallikrein-kinin system of the blood following hypothalamo-hypophyseal stimulation of animals of different ages].
abstract: Changes occurring in the formation and synthesis of kinins become irregular with ageing: the content of kallikreinogenes decreases, the activity of kininase and inhibitors of trypsin falls, and total blood activity of hydrolysis of ethyl--N--benzoil--L--arginine ether rises. Stimulation of the hypothalamus causes an obvious activation of the kalikrein--kinin system in adult animals: the contents of kallikreinogenes and kininogenes fall, the kallikrein activity sharply increases, whereas the kininase activity decreases. Both single and repeated administrations of vasopressin induce the same shifts of kallikrein--kinin system as the stimulation of hypothalamus. On repeated administrations of vasopressin the kininase activity rises.
mesh_terms: D000367:Age Factors; D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology*; D001920:Bradykinin / Q000494:pharmacology*; D002265:Carboxylic Ester Hydrolases / Q000097:blood; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology*; D007610:Kallikreins / Q000097:blood*; D007704:Kininogens / Q000097:blood; D007705:Kinins / Q000097:blood*; D001121:Lysine Carboxypeptidase / Q000097:blood; D011288:Prekallikrein / Q000097:blood; D011817:Rabbits; D051381:Rats; D014361:Trypsin Inhibitors / Q000097:blood
chemical_list: D007704:Kininogens; D007705:Kinins; D014361:Trypsin Inhibitors; D001127:Arginine Vasopressin; D011288:Prekallikrein; D002265:Carboxylic Ester Hydrolases; D001121:Lysine Carboxypeptidase; D007610:Kallikreins; D001920:Bradykinin
vernacular_title: Izmeneniia kallikrein-kininovoĭ sistemy krovi pri gipotalamo-gipofizarnoĭ stimuliatsii u zhivotnykh raznogo vozrasta.