Interactions between neuraminidase-treated lymphocytes and liver cells.
Neuraminidase-treated rat lymphocytes and rat hepatocytes spontaneously aggregate when mixed in vitro. Adhesion between cells is due to stereo-specific interactions between a mammalian hepatic membrane lectin and galactosyl residues which are exposed on the lymphocyte surface after removal of sialic acid residues. The hepatic galactose specific lectin may play a role in the accumulation of recirculating desialylated lymphocytes in the liver.
D000116:Acetylgalactosamine / Q000494:pharmacology; D000255:Adenosine Triphosphate / Q000096:biosynthesis; D000818:Animals; D002465:Cell Movement; D003078:Colchicine / Q000494:pharmacology; D003571:Cytochalasin B / Q000494:pharmacology; D005690:Galactose / Q000494:pharmacology; D008099:Liver / Q000166:cytology* / Q000276:immunology; D008211:Lymphocyte Cooperation; D008214:Lymphocytes / Q000276:immunology; D009439:Neuraminidase / Q000494:pharmacology*; D051381:Rats; D012397:Rosette Formation
D003571:Cytochalasin B; D000255:Adenosine Triphosphate; D009439:Neuraminidase; D000116:Acetylgalactosamine; D003078:Colchicine; D005690:Galactose