Suppression of cellular immune response in chemically sympathectomized mice.
Delayed-type hypersensitivity to methylated bovine serum albumin (MBSA), as induced by 6-hydroxydopamine (6-OHDA) was studied in chemically sympathectomized mice. Footpad reaction at 48 h after challenge injection of MBSA was suppressed with doses ranging from 10--300 mg/kg. 6-OHDA was neither cytotoxic to peritoneal macrophages nor was the function of immunoglobulin mediated phagocytosis suppressed. Thus, the suppression of delayed-type hypersensitivity may be attributed to interference with T-cell function.
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D005260:Female; D006892:Hydroxydopamines / Q000494:pharmacology; D006968:Hypersensitivity, Delayed; D007111:Immunity, Cellular / Q000187:drug effects*; D007136:Immunoglobulins / Q000502:physiology; D008264:Macrophages / Q000187:drug effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010587:Phagocytosis / Q000187:drug effects; D013564:Sympathetic Nervous System / Q000187:drug effects*
D006892:Hydroxydopamines; D007136:Immunoglobulins