Evaluation of fast neutron teletherapy for advanced carcinomas of the major salivary glands.
This review analyzes the local control rate of fast neutron beam teletherapy for malignant salivary gland carcinomas compared to conventional photon irradiation at the same institution. Thirty patients with malignant parotid or submaxillary gland tumors were treated with either cobalt-60 (19 patients) or neutrons +/- photons (11 patients). The 19 photon-treated patients were historical controls. No advantage is found for neutrons in patients with tumors less than 3 cm where 100% local control was achieved with either modality. In patients with tumor masses 3-6 cm in size, neutrons demonstrated a possible advantage with a local control rate of 100% (followup, 7-18 months) compared to a control rate of 33% with conventional photon irradiation. Acute treatment-related morbidity was slightly greater in neutron-treated patients, but no long-term complications have been observed to date.
D005069:Evaluation Studies as Topic; D005214:Fast Neutrons / Q000627:therapeutic use*; D006801:Humans; D009502:Neutrons / Q000627:therapeutic use*; D010307:Parotid Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D011832:Radiation Injuries; D011867:Radioisotope Teletherapy; D012075:Remission, Spontaneous; D012468:Salivary Gland Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D012867:Skin / Q000528:radiation effects; D013363:Submandibular Gland