[Effect of dermatocorticoids on the activity of hepatic tryptophane pyrrolase in the guinea pig (author's transl)].
The enzyme activity of tryptophane pyrrolase in guinea pig liver can be measurably increased--as in other mammalian species--by systemic administration of corticoids, but this effect is short-lived and achieved only with high s.c. doses of, e.g., prednisolone (Ultracorten-H-hydrosoluble). In contradistinction and rather surprisingly the enzyme activity is variably  but markedly reduced by high-dosed and protracted epicutaneous application (10 times within 2 weeks) of the well-known dermatocorticoids: hydrocortisone, fluocinolone acetonide, and clobetasol propionate. This reaction must be explained by the capacity of these corticoids to inhibit, after their percutaneous absorption, the functional axis pituitary--adrenal cortex--liver, the stimulatory role of which is mandatory for the endogenous basic activity of hepatic tryptophane pyrrolase.
D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002990:Clobetasol / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology; D005446:Fluocinolone Acetonide / Q000008:administration & dosage / Q000494:pharmacology; D005938:Glucocorticoids; D006168:Guinea Pigs; D006854:Hydrocortisone; D008099:Liver / Q000201:enzymology* / Q000502:physiology; D008297:Male; D010913:Pituitary-Adrenal System / Q000502:physiology; D014366:Tryptophan Oxygenase / Q000378:metabolism*
D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D005446:Fluocinolone Acetonide; D002990:Clobetasol; D014366:Tryptophan Oxygenase; D006854:Hydrocortisone
Wirkung von Dermatocorticoiden auf die Aktivität der hepatischen Tryptophanpyrrolase beim Meerschweinchen.