Treatment of experimental Naegleria meningoencephalitis with a combination of amphotericin B and rifamycin.
The treatment of primary amoebic meningoencephalitis was examined using a mouse model. Rifamycin by itself was ineffective. However, a synergistic effect was observed when used in combination with amphotericin B. This finding may prove useful in the treatment of patients with primary amoebic meningoencephalitis, for which satisfactory treatment is currently unavailable.
D000562:Amebiasis / Q000188:drug therapy*; D000666:Amphotericin B / Q000627:therapeutic use*; D000818:Animals; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D008590:Meningoencephalitis / Q000188:drug therapy*; D051379:Mice; D008807:Mice, Inbred BALB C; D012294:Rifamycins / Q000627:therapeutic use*
D012294:Rifamycins; D000666:Amphotericin B