title: Mutation rates, population sizes and amounts of electrophoretic variation of enzyme loci in natural populations.
abstract: A method is presented for estimating relative mutation rates or relative effective population sizes, under the hypothesis of adaptively neutral allelic variation. This method was applied to seven surveys of electrophoretic variation. It was observed that electrophoretic mutation rates so obtained follow the gamma distribution and, in Drosophila, are positively correlated with the molecular weights of the enzymes subunits. The variance in mutation rate is larger under the step-wise model of electrophoretic mutation than under the infinite-alleles model. Rates for the most variable loci may exceed rates for less variable loci by a factor of 500. For completely invariant loci, this factor may be as high as 4 X 10(4), an observation suggesting that these loci are subject to purifying selection. In contrast to mutation rates, effective population sizes may vary at the most by a factor of ten. These results support the hypothesis that differences in the amount of electrophoretic variability among polymorphic loci may reflect differences in the rate by which electrophoretically detectable variation is generated in population.
mesh_terms: D000818:Animals; D004586:Electrophoresis; D004798:Enzymes / Q000235:genetics*; D014644:Genetic Variation; D006801:Humans; D008433:Mathematics; D008957:Models, Genetic; D009154:Mutation; D011110:Polymorphism, Genetic; D011156:Population Density
chemical_list: D004798:Enzymes