Toxin-neutralizing effect of antibody against subtilisin-digested tetanus toxin.
A form of systemic tetanus with atypical symptoms was observed in mice injected in the left thigh with a mixture of tetanus toxin and antibody produced in guinea pigs against a fragment of toxin obtained from a subtilisin digest of the crystallized toxin. The mice did not show typical symptoms of the local tetanus such as convulsions or spastic paralysis of the injected limb.
D000818:Animals; D051379:Mice; D009500:Neutralization Tests; D013381:Subtilisins; D013742:Tetanus / Q000209:etiology* / Q000473:pathology; D013743:Tetanus Antitoxin / Q000008:administration & dosage / Q000494:pharmacology*; D013744:Tetanus Toxin / Q000633:toxicity*
D013743:Tetanus Antitoxin; D013744:Tetanus Toxin; D013381:Subtilisins