Interaction of influenza A virus with human peripheral blood lymphocytes.
Peripheral blood lymphocytes cultured in the presence of phytohemagglutinin, concanavalin A, or pokeweed mitogen were exposed in vitro to influenza A virus. The synthesis of several virus-specific proteins, including the nucleoprotein, membrane protein, and nonstructural 1 protein were detected, although no infectious virus was produced by the lymphocyte cultures. Evidence was obtained that only a subpopulation of mitogen-transformed cells would support virus protein synthesis. A comparison of the interactions of influenza A virus with lymphocytes from normal individuals and from rheumatoid arthritis patients showed that the same range of virus-specific proteins were made, in similar quantities, regardless of the source of lymphocytes.
D001172:Arthritis, Rheumatoid / Q000276:immunology / Q000382:microbiology; D002478:Cells, Cultured; D006801:Humans; D009980:Influenza A virus / Q000276:immunology / Q000378:metabolism*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology* / Q000382:microbiology; D014764:Viral Proteins / Q000096:biosynthesis; D014779:Virus Replication
D014764:Viral Proteins