The effect of spironolactone on the arterial water, cation, and norepinephrine contents of control and 'one-kidney-one-clip' hypertensive dogs.
Spironolactone at 10 mg per kilogram per day was given to control and 'one-kidney-one-clip' hypertensive dogs for 6--7 weeks. Compared with untreated animals the treated animals had a lower arterial water content, a higher arterial, myocardial, and skeletal muscle sodium content, and variable changes in tissue potassium concentrations.
D000818:Animals; D001158:Arteries / Q000378:metabolism*; D001834:Body Water / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D002412:Cations / Q000378:metabolism*; D004285:Dogs; D006973:Hypertension / Q000378:metabolism*; D008274:Magnesium / Q000378:metabolism; D009132:Muscles / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism; D012964:Sodium / Q000378:metabolism; D013148:Spironolactone / Q000494:pharmacology*
D002412:Cations; D013148:Spironolactone; D012964:Sodium; D008274:Magnesium; D011188:Potassium; D002118:Calcium; D009638:Norepinephrine