Mutagenicity of vinyl chloride, vinylidene chloride and chloroprene in V79 Chinese hamster cells.
The mutagenicity of vinyl chloride, vinylidene chloride (1,1-dichloroethylene) and chloroprene (2-chloro-1,3-butadiene) was tested in V79 Chinese hamster cells in the presence of a 15 000 x g liver supernatant from phenobarbitone-pre-treated rats and mice. Mutations in terms of 8-azaguanine and ouabain resistance were induced in a dose-related fasion by exposure to vapour of vinyl chloride in the presence of liver supernatant from phenobarbitone-pretreated rats. Vapours of vinylidene chloride and chloroprene induced a dose-related toxicity in the presence of liver supernatant from phenobarbitone-retreated rats, but these two compounds were not mutagenic in V79 Chinese hamster cells under the present assay conditions. The results are discussed with regard to the metabolic activation of the compounds and to the correlation with their carcinogenicity in man and experimental animals.
D000818:Animals; D001375:Azaguanine / Q000494:pharmacology; D002070:Butadienes / Q000494:pharmacology*; D002460:Cell Line; D002737:Chloroprene / Q000494:pharmacology*; D006224:Cricetinae; D003412:Cricetulus; D004000:Dichloroethylenes / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004351:Drug Resistance; D006843:Hydrocarbons, Chlorinated / Q000494:pharmacology*; D009153:Mutagens; D010042:Ouabain / Q000494:pharmacology; D010641:Phenotype; D014752:Vinyl Chloride / Q000494:pharmacology*; D014753:Vinyl Compounds / Q000494:pharmacology*
D002070:Butadienes; D004000:Dichloroethylenes; D006843:Hydrocarbons, Chlorinated; D009153:Mutagens; D014753:Vinyl Compounds; D002737:Chloroprene; D010042:Ouabain; D001375:Azaguanine; D014752:Vinyl Chloride