Regional vascular reactivity in rats with Guérin carcinoma (GC).
Increased sensitivity to phenylephrin and a decreased one to isoproterenol has been found in regional vascular beds of GC implanted rats. Circulatory sympathetic reflex adaptation, alfa- and beta-adrenergic stimulation or blockade provoked a uniform response pattern: i.e. increase in vascular resistance of GC.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002277:Carcinoma / Q000503:physiopathology*; D002302:Cardiac Output / Q000187:drug effects; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009374:Neoplasms, Experimental / Q000503:physiopathology; D010643:Phenoxybenzamine / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D012039:Regional Blood Flow / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
D010643:Phenoxybenzamine; D010656:Phenylephrine; D011433:Propranolol; D007545:Isoproterenol