Phenotyping of South African black tuberculosis patients for inactivation of isoniazid.
Studies of isoniazid inactivation rates in black tuberculosis patients from South Africa and Birmingham, Alabama, showed a higher frequency of fast inactivation than those of North American Caucasian patients. After an oral test dose of 10 mg/kg isoniazid the percentage of fast inactivators in black patients of South Africa and Alabama was close to 60% while in North American white participants (Canadian and Birmingham Caucasians), the frequency of fast inactivation was approximately 40%.
D000284:Administration, Oral; D044383:Black People; D006801:Humans; D007273:Injections, Intramuscular; D007538:Isoniazid / Q000008:administration & dosage / Q000378:metabolism*; D007700:Kinetics; D010641:Phenotype; D013019:South Africa; D014397:Tuberculosis, Pulmonary / Q000235:genetics / Q000378:metabolism*; D044465:White People
D007538:Isoniazid