Effects of aspirin and dimenhydrinate (Dramamine) on visual processes.
1. The effect of three doses of either aspirin (1280 mg each) or dimenhydrinate (Dramamine) (100 mg each) in an 8 h period on visual processes was investigated double-blind on sixteen volunteer subjects. 2. Tests included night-vision, colour-discrimination, stereoacuity and stereopsis, reaction-time, pupil size, eye-movements, visual evoked cortical potentials, electroencephalographs, a dial-reading task, and a test of texture discrimination. 3. Both drugs affected colour discrimination, and dimenhydrinate degraded night-vision, reaction-time, and stereopsis. 4. The effect of aspirin was minor, but the impairments produced by dimenhydrinate appear to be of practical importance.
D000328:Adult; D001241:Aspirin / Q000494:pharmacology*; D003118:Color Perception / Q000187:drug effects; D004111:Dimenhydrinate / Q000494:pharmacology*; D004192:Discrimination, Psychological / Q000187:drug effects; D004569:Electroencephalography; D005071:Evoked Potentials / Q000187:drug effects; D005133:Eye Movements / Q000187:drug effects; D006801:Humans; D008297:Male; D010775:Photic Stimulation; D011680:Pupil / Q000187:drug effects; D011930:Reaction Time / Q000187:drug effects; D014785:Vision, Ocular / Q000187:drug effects*
D004111:Dimenhydrinate; D001241:Aspirin