[Spasmolytic properties of pyrrolizidine alkaloids].
Acute toxicity, spasmolytic and hypotensive properties of the alkaloids senecionine, d-otocenine and floridanin isolated from Senecio Erraticum L. were studied. D-otocenine and floridanin elicited low toxicity, while senecionine and d-otosenine showed spasmolytic and floridanin predominantly hypotensive properties.
D000818:Animals; D002339:Carotid Arteries / Q000187:drug effects; D002415:Cats; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D051379:Mice; D009130:Muscle, Smooth / Q000187:drug effects; D010276:Parasympatholytics; D011763:Pyrrolizidine Alkaloids / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D014655:Vascular Resistance / Q000187:drug effects
D010276:Parasympatholytics; D011763:Pyrrolizidine Alkaloids
Spazmoliticheskie svoĭstva pirrolizidinovykh alkaloidov.