title: Ultraviolet-mediated cytotoxic activity of phenylheptatriyne from Bidens pilosa L.
abstract: The tropical weed Bidens pilosa L. (Asteraceae) contains a number of polyacetylenes which are phototoxic to bacteria, fungi, and human fibroblast cells in the presence of sunlight, artificial sources of long-wave ultraviolet light, or cool-white fluorescent light. The principle photoactive compound in the leaf, phenylheptatriyne, is present in the cuticle as well as in the underlying cells. Experiments with calf thymus DNA indicate that, unlike photoactive furanocoumarins, phenylheptatriyne does not form interstrand cross linkages with DNA in ultraviolet light.
mesh_terms: D000480:Alkynes / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents; D001419:Bacteria / Q000187:drug effects / Q000528:radiation effects; D002417:Cattle; D002470:Cell Survival / Q000187:drug effects* / Q000528:radiation effects; D004247:DNA / Q000378:metabolism; D005347:Fibroblasts / Q000187:drug effects / Q000528:radiation effects; D005658:Fungi / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D008730:Methoxsalen / Q000494:pharmacology; D010944:Plants / Q000032:analysis*; D014466:Ultraviolet Rays
chemical_list: D000480:Alkynes; D000900:Anti-Bacterial Agents; C019518:phenylheptatriyne; D004247:DNA; D008730:Methoxsalen