Taurine transport in renal brush-border-membrane vesicles.
Taurine transport in isolated brush-border-membrane vesicles from rat kidney is concentrative and it is driven by the Na+ gradient and transmembrane potential difference; binding is not a significant component of net uptake. The Na+-dependent component of net uptake is saturable with an apparent Km of 17 microM. The taurine-transport mechanism is selective for beta-amino compounds.
D000596:Amino Acids / Q000494:pharmacology; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002462:Cell Membrane / Q000378:metabolism*; D066298:In Vitro Techniques; D007672:Kidney Cortex / Q000166:cytology / Q000378:metabolism*; D008871:Microvilli / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism; D051381:Rats; D012964:Sodium / Q000378:metabolism; D013654:Taurine / Q000378:metabolism*
D000596:Amino Acids; D013654:Taurine; D012964:Sodium; D011188:Potassium