Antibody-mediated immunosuppression of a cytotoxic cell response not involving a simple antigen-masking mechanism.
An in vitro cytotoxic cell response against alloantigens was inhibited by antibody directed against the alloantigens and also by anti-trinitrophenyl antibody provided that the allogeneic stimulator cells were modified with trinitrophenyl. Inhibition of an anti-allogeneic cytotoxic cell response against trinitrophenyl-coupled allogeneic stimulator cells by anti-trinitrophenyl antibody is dependent upon the intact Fc portion of inhibitory antibody. The magnitude of the difference between intact and F(ab')2 anti-trinitrophenyl antibody in immunosuppressive activity suggests that the Fc portion emits negative signals rather than simply adding to a steric hindrance effect.
D000818:Animals; D000918:Antibody Specificity; D000920:Antibody-Dependent Cell Cytotoxicity; D002478:Cells, Cultured; D007141:Immunoglobulin Fc Fragments / Q000276:immunology; D007165:Immunosuppression Therapy; D007519:Isoantigens; D051379:Mice; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D014301:Trinitrobenzenes / Q000276:immunology
D007141:Immunoglobulin Fc Fragments; D007519:Isoantigens; D014301:Trinitrobenzenes