title: Effects of cadmium on polyribosome sedimentation pattern in mouse liver.
abstract: Cadmium injected to mice provokes an acute disaggregation of hepatic polyribosomes. The effect appears within 15 min, it is maximal after 1 h and then gradually disappears. The reaggregation of polyribosomes takes place 6--12 h after injection. The disaggregation of polyribosomes is linear with log doses in a range of 7.25--20 mumol/kg CdCl2. Cycloheximide pretreatment prevents the disaggregation of polyribosomes in the livers of cadmium-treated mice.
mesh_terms: D000818:Animals; D002104:Cadmium / Q000494:pharmacology*; D003513:Cycloheximide / Q000494:pharmacology; D008099:Liver / Q000187:drug effects* / Q000648:ultrastructure; D008297:Male; D051379:Mice; D008970:Molecular Weight; D011132:Polyribosomes / Q000187:drug effects*
chemical_list: D002104:Cadmium; D003513:Cycloheximide