Inhibition of cilia regeneration of Tetrahymena by ansamitocins, new antitumor antibiotics.
Ansamitocins inhibited cilia regeneration of partially deciliated Tetrahymena pyriformis W, and the activity depended on the acyl groups at the C3 position.
D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D002923:Cilia / Q000502:physiology; D008453:Maytansine / Q000031:analogs & derivatives / Q000494:pharmacology*; D010078:Oxazines / Q000494:pharmacology*; D012038:Regeneration; D013768:Tetrahymena / Q000187:drug effects* / Q000254:growth & development
D000903:Antibiotics, Antineoplastic; D010078:Oxazines; D008453:Maytansine