Hypertension and aldosterone overproduction without renin suppression in Cushing's syndrome from an adrenal adenoma.
Adrenal steroids and compenents of the renin-angiotensin system were measured before and after adrenalectomy in a woman with Cushing's syndrome and hypertension from a functioning adrenocortical adenoma. Aldosterone, deoxycorticosterone and cortisol were produced in excess by the adenoma, and were measured in tumor tissue. High plasma renin substrate concentrations, and normal basal and furosemide-stimulated plasma renin activities and plasma renin concentrations which were present before surgery, decreased after adrenalectomy, and the hypertension diminished. The inappropriately normal levels of renin and potassium in this patient, despite autonomous aldosterone overproduction, suggest an ineffective mineralocorticoid action of aldosterone, possibly from interaction with her other adenoma-produced steroids. The decrease in components of the renin-angiotensin system suggests a partial renin-dependence of her hypertension.
D000236:Adenoma / Q000150:complications / Q000378:metabolism; D000306:Adrenal Cortex Neoplasms / Q000150:complications / Q000378:metabolism; D000328:Adult; D000450:Aldosterone / Q000378:metabolism*; D003345:Corticosterone / Q000378:metabolism; D003480:Cushing Syndrome / Q000201:enzymology / Q000209:etiology / Q000378:metabolism*; D003900:Desoxycorticosterone / Q000378:metabolism; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D006973:Hypertension / Q000209:etiology*; D012083:Renin / Q000378:metabolism*
D003900:Desoxycorticosterone; D000450:Aldosterone; D012083:Renin; D003345:Corticosterone; D006854:Hydrocortisone