Activity of some drugs on the electroencephalogram of curarized rats during acute and iterative hypercapnic anoxia Hypotheses on mechanisms of action.
The present study is related to the activity of some drugs in a test of acute and iterative hypercapnic anoxia in curarized rats. The interpretation of the results is based on the values of cerebral resistance to anoxia and on the duration of post-anoxic recovery and cerebral electric silence, i.e. the duration of "nul" electroencephalogram. Results obtained allow us to put forward some hypotheses about mechanisms of action. Cerebral or systemic vasodilation or vasoconstriction both seem to be excluded. Membrane activity as well as an increase in cerebral blood perfusion pressure or an impact at the level of the brain neurotransmitters may be taken into consideration. Furthermore, it is possible that extracerebral phenomena (cardiovascular, respiratory, within the blood cells for example) could interact with cerebral phenomena. It would be necessary to undertake further, more extensive studies if we wish to evaluate the potential interest of the experimental model used and the way in which the drugs proposed as treatment for cerebrovascular diseases or ageing processes work.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004569:Electroencephalography; D006339:Heart Rate / Q000187:drug effects; D006935:Hypercapnia / Q000503:physiopathology*; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D051381:Rats; D013997:Time Factors; D014403:Tubocurarine / Q000494:pharmacology*
D014403:Tubocurarine