[Histochemical and ultrastructural characteristics of embryonal hepatocytes exposed to chloridin (pyrimethamine)].
Single injection of chloridine to rats on the 13th day of pregnancy causes the disturbance of morphofunctional processes in embryo hepatocytes, stimulates granular endoplasmatic reticulum development and glycogen accumulation, increases the number and size of lysosomes, breaks their integrity, produces destructive changes in mitochondria. Activity of lysosomal enzymes with depolymerazing action increases already 30 min after the drug injection, their histopography changes, DNA content decreases.
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D004247:DNA / Q000378:metabolism; D003851:Deoxyribonucleases / Q000378:metabolism; D005260:Female; D005865:Gestational Age; D006651:Histocytochemistry; D008099:Liver / Q000196:embryology* / Q000378:metabolism / Q000648:ultrastructure; D008112:Liver Glycogen / Q000378:metabolism; D008431:Maternal-Fetal Exchange; D008854:Microscopy, Electron; D011247:Pregnancy; D011739:Pyrimethamine / Q000506:poisoning*; D051381:Rats; D012260:Ribonucleases / Q000378:metabolism
D008112:Liver Glycogen; D004247:DNA; D003851:Deoxyribonucleases; D012260:Ribonucleases; D000135:Acid Phosphatase; D011739:Pyrimethamine
Gistokhimicheskaia i ul'trastrukturnaia kharakteristika émbrional'nogo gepatotsi ta pri deĭstvii khloridina (primethamina).