title: Effect of fenbendazole on Toxocara canis larvae in tissues of infected dogs.
abstract: The effect of fenbendazole therapy was studied in six dogs fed 10,000 embryonated Toxocara canis eggs. At 47 days after they were fed T canis, four dogs were given fenbendazole in two divided doses totaling 50 mg/kg of body weight each day for 14 days. Two infected dogs were not given fenbendazole. All dogs were necropsied at the end of treatment and the foci were counted in the lungs; their skeletal muscles were digested in 1% trypsin for the recovery of larvae. The T canis larvae were not recovered from the skeletal muscle of the four infected dogs treated with fenbendazole; 15 and 42 larvae/100 g of skeletal muscle were recovered from the two nonmedicated infeected dogs. The number of grossly visible foci on surfaces of lungs in treated dogs was markedly less than in the nonmedicated infected dogs. The results indicate that fenbendazole might be effective in preventing prenatal infection in dogs.
mesh_terms: D000818:Animals; D001196:Ascariasis / Q000662:veterinary*; D001562:Benzimidazoles / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy* / Q000469:parasitology; D004285:Dogs; D005273:Fenbendazole / Q000627:therapeutic use*; D008168:Lung / Q000469:parasitology; D014120:Toxocariasis / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*
chemical_list: D001562:Benzimidazoles; D005273:Fenbendazole