title: Synthesis of substituted 2-aminopyrrole analogs of lidocaine II.
abstract: The synthesis and local anesthetic and antiarrhythmic properties of eight substituted 2-diethylaminoacetamido-3-carbamyl-4-methylpyrroles are described. Three compounds showed significant local anesthetic activity by the guinea pig wheal test, and four showed antiarrhythmic activity against chloroform-induced ventricular arrhythmias in mice.
mesh_terms: D000779:Anesthetics, Local; D000818:Animals; D000889:Anti-Arrhythmia Agents; D001281:Atrial Fibrillation / Q000188:drug therapy; D055598:Chemical Phenomena; D002621:Chemistry; D006168:Guinea Pigs; D008012:Lidocaine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D008297:Male; D051379:Mice; D011758:Pyrroles / Q000138:chemical synthesis / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000779:Anesthetics, Local; D000889:Anti-Arrhythmia Agents; D011758:Pyrroles; D008012:Lidocaine