Plasma catecholamines in man are not influenced by the inhibition of prostaglandin synthesis.
Indomethacin has been reported to potentiate the release of noradrenaline from sympathetic nerve endings in vitro and to increase urinary noradrenaline excretion in rats. We have studied the influence of indomethacin on plasma catecholamine levels in 10 normal men, using measurement of plasma renin activity (PRA) as an index of the pharmacodynamic effect of indomethacin. Both in the supine and standing positions indomethacin failed to alter the plasma concentrations of noradrenaline, adrenaline or dopamine, while PRA was markedly suppressed. It is concluded that in the intact human indomethacin does not influence catecholamine concentrations.
D000328:Adult; D002395:Catecholamines / Q000097:blood*; D004298:Dopamine / Q000097:blood; D004837:Epinephrine / Q000097:blood; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D009638:Norepinephrine / Q000097:blood; D011187:Posture; D011453:Prostaglandins / Q000096:biosynthesis*; D012083:Renin / Q000097:blood
D002395:Catecholamines; D011453:Prostaglandins; D012083:Renin; D004298:Dopamine; D009638:Norepinephrine; D007213:Indomethacin; D004837:Epinephrine