title: 125I-Insulin is preferentially internalized in regions of the hepatocytes rich in lysosomal and Golgi structures.
abstract: 125I-Insulin initially localizes to the plasma membrane of isolated rat hepatocytes but is subsequently internalized and preferentially associates with lysosomal structures. In the present study, we show that this preferential association to lysosomes occurs in regions of the cell rich in lysosomal and Golgi structures.
mesh_terms: D000818:Animals; D001345:Autoradiography; D006056:Golgi Apparatus / Q000378:metabolism*; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism*; D007457:Iodine Radioisotopes; D008099:Liver / Q000378:metabolism*; D008247:Lysosomes / Q000378:metabolism*; D051381:Rats
chemical_list: D007328:Insulin; D007457:Iodine Radioisotopes