title: Pharmacological and clinical importance of narcotic antagonists and mixed antagonists--use in cardiology.
abstract: 1 The treatment of pain of cardiac origin requires a knowledge of the haemodynamic action of the analgesic agents used. 2 The haemodynamic effects of morphine, diamorphine, pavaveretum, pethidine and pentazocine are reviewed. 3 Clinical experience with the new antagonist analgesic buprenorphine is reported. 4 These studies indicate that buprenorphine may be the agent of choice for the relief of severe pain in patients with unstable circulation.
mesh_terms: D002047:Buprenorphine / Q000627:therapeutic use; D006331:Heart Diseases / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D009203:Myocardial Infarction / Q000188:drug therapy / Q000503:physiopathology; D009292:Narcotic Antagonists / Q000627:therapeutic use*; D010146:Pain; D013329:Structure-Activity Relationship
chemical_list: D009292:Narcotic Antagonists; D002047:Buprenorphine