Ventricular fluid levels of chloramphenicol in infants.
Investigation of two infants suggested that peak ventricular fluid levels of chloramphenicol after intravenous administration were achieved after 3 h. The penetration of chloramphenicol into ventricular fluid may be unpredictable. In one patient, the peak ventricular fluid level was 57.5% of the peak serum level, and it was only 22.5% in the other patient. This observation may explain some of the past treatment failures when chloramphenicol was utilized in patients with gram-negative ventriculitis and meningitis.
D001927:Brain Diseases / Q000209:etiology; D002552:Cerebral Ventricles; D002701:Chloramphenicol / Q000134:cerebrospinal fluid* / Q000627:therapeutic use; D006801:Humans; D006849:Hydrocephalus / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D007231:Infant, Newborn
D002701:Chloramphenicol