A rare electrophoretic enzyme variant of serum alkaline phosphatase in a group of Icelanders.
An electrophoretic isoenzyme variant of serum alkaline phosphatase was found in 10 out of 343 subjects belonging to an Icelandic population in Husavik and the Husavik region. 9 of the variant-positive subjects were women. The enzyme variant differs from normal isoenzymes in electrophoretic mobility, substrate specificity, and response to inhibitors. It could be demonstrated that nine of the subjects with the enzyme variant were related with each other.
D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood / Q000235:genetics*; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D014644:Genetic Variation; D006801:Humans; D007055:Iceland; D007527:Isoenzymes / Q000097:blood / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010375:Pedigree
D007527:Isoenzymes; D000469:Alkaline Phosphatase