[Role of the acetylcholine--cholinesterase system in the development of epilepsy].
The report pertains to some data on the cholinesterase activity in the blood serum and CSF of 62 patients with epilepsy, in correlation with different clinical characteristics (the severity of the disease, the character of the EEG, frequency of seizures, treatment efficacy, etc). In 86,8% of the cases there was a significant increase in the activity of serum cholinesterase. Increased cholinesterase activity correlated only with pronounced pathological changes in the EEG (reverse correlation) and the efficacy of treatment (direct correlation). After surgical treatment of 9 cases there was a drop in the cholinesterase activity of the blood serum and CSF, which correlated with an improvement in the general state of the patients. On the basis of personal experience, as well as literary data, it is assumed that an increase in the cholinesterase activity in epileptic patients is not related to the main etiological factors of this disease but is rather a secondary change, a peculiar "symptom" of the disease.
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002802:Cholinesterases / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D004827:Epilepsy / Q000378:metabolism* / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D002802:Cholinesterases
O roli sistemy atsetilkholin--kholinésteraza v razvitii épilepsii.