title: [Characteristics of the development of acute toxic hepatitis in rats stimulated with prodigiozan].
abstract: Acute toxic hepatitis was induced in Wistar rats by means of a single injection of 40% CCl4 on a peach-kernell oil base (0.2 ml/100 g body weight). Under conditions of stimulation with the bacterial polysaccharide prodigiosan, the resistance of hepatocytes to CCl4 sharply increased, which was shown by diminished severity of hepatic parenchyma destruction.
mesh_terms: D000208:Acute Disease; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000503:physiopathology; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D005260:Female; D008115:Liver Regeneration / Q000187:drug effects; D008297:Male; D010586:Phagocytes / Q000187:drug effects; D011135:Polysaccharides, Bacterial / Q000494:pharmacology*; D011354:Prodigiozan / Q000494:pharmacology*; D051381:Rats; D013268:Stimulation, Chemical; D013997:Time Factors
chemical_list: D011135:Polysaccharides, Bacterial; D011354:Prodigiozan
vernacular_title: Osobennosti razvitiia ostrogo toksicheskogo gepatita u krys, stimulirovannykh prodigiozanom.