title: Acridine araphanes: a new class of probe molecules for biological systems.
abstract: The bis-acridine ring system forms the basis for new biophysical probes of novel stereochemistry. Spectral data indicate that certain alkylene bridged bis-9-aminoacridines have a parallel plane conformation of predictable interplane distance. The parallel plane conformation is independent of solvent and thus is different from nucleic acid systems. This stable conformation allows these compounds to be used as sensitive "rulers" for describing binding site geometry in cholinergic enzymes and in the delineation of the mechanism of allosteric control in acetylcholinesterase.
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000166:Acridines; D001665:Binding Sites; D007700:Kinetics; D008968:Molecular Conformation; D010766:Phosphorylation; D011487:Protein Conformation; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000166:Acridines; D000110:Acetylcholinesterase