Persistent warts protected from immune attack by a blocking factor.
Severe warts of 20 years duration, highly resistant to therapy, were found to contain a soluble factor which blocked the local expression of cellular immunity, without affecting systemic immune responsiveness. This finding enabled us to propose therapy by infection, and this had a limited success.
D000328:Adult; D002464:Cell Migration Inhibition; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007167:Immunotherapy; D007962:Leukocytes / Q000276:immunology; D012871:Skin Diseases / Q000276:immunology* / Q000628:therapy; D014616:Vaccinia virus / Q000276:immunology; D014860:Warts / Q000276:immunology* / Q000628:therapy