Regional distribution of amino acids in Friedreich's ataxia brains.
The distribution of amino acids in two Friedreich's ataxia brains is compared to 4 control brains. Glutamate and GABA were decreased in the cerebellar hemispheres and/or in the vermis. Taurine concentrations were uniformly elevated throughout the areas studied. Taurine/glutamate and taurine/GABA ratios were consistently elevated in Friedreich's ataxia brains, whereas glutamate/glutamine ratios were consistently decreased (with normal glutamine concentrations).
D000596:Amino Acids / Q000378:metabolism*; D001224:Aspartic Acid / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D002529:Cerebellar Nuclei / Q000378:metabolism; D002531:Cerebellum / Q000378:metabolism; D005621:Friedreich Ataxia / Q000378:metabolism*; D005727:Ganglia, Spinal / Q000378:metabolism; D005971:Glutamates / Q000378:metabolism; D006801:Humans; D009847:Olivary Nucleus / Q000378:metabolism; D012012:Red Nucleus / Q000378:metabolism; D013116:Spinal Cord / Q000378:metabolism; D013654:Taurine / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D000596:Amino Acids; D005971:Glutamates; D013654:Taurine; D001224:Aspartic Acid; D005680:gamma-Aminobutyric Acid