Rubella seroconversion following immunization in a rural practice.
One hundred two consecutive patients with verifiable immunization to rubella were studied in a rural West Virginia county. Hemagglutination Inhibiting (HI) antibody titres, age at immunization, and elapsed time since immunization were recorded. Twenty-three (22.5 percent) had HI titres less than 1:8. There was no statistically significant difference in whether immunization at less than 15 months or more than 15 months of age resulted in a titre of greater than or equal to 1:8. There was no evident change in group proportion of seroconversion with time; either the child initially had a seroconversion with immunization, or he/she did not. A relatively large number of children with verified immunization to rubella do not have a titre currently considered protective to rubella. This does not seem to vary with time since immunization or age at immunization.
D000293:Adolescent; D000914:Antibodies, Viral / Q000032:analysis*; D000917:Antibody Formation; D002648:Child; D002675:Child, Preschool; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007114:Immunization; D012409:Rubella / Q000517:prevention & control*; D012424:Rural Population; D013997:Time Factors; D014903:West Virginia
D000914:Antibodies, Viral