Biochemical characterization of the proliferation pool of lymphatic cells in the human tonsil and demonstration of the age-dependent pool size reduction.
The DNA and RNA content and also the thymidine and uridine incorporation kinetics were determined in peripheral lymphocytes and lymphatic cells of the tonsil. The existence of a proliferation pool of lymphoid cells in the tonsil could be established by the comparison of all data. An age-conditioned reduction of the pool size was assumed from the uridine incorporation rate which takes place faster than the organo-specific cell decrease likewise conditioned by age in the tonsil. The abscess tonsil could be explained as a pathological state with considerable reduction of proliferation.
D000328:Adult; D000367:Age Factors; D002455:Cell Division; D002648:Child; D002675:Child, Preschool; D004247:DNA / Q000096:biosynthesis / Q000378:metabolism; D006801:Humans; D007958:Leukocyte Count; D008214:Lymphocytes / Q000378:metabolism*; D014066:Palatine Tonsil / Q000166:cytology* / Q000378:metabolism; D012313:RNA / Q000096:biosynthesis / Q000378:metabolism; D013936:Thymidine / Q000378:metabolism; D014529:Uridine / Q000378:metabolism
D012313:RNA; D004247:DNA; D013936:Thymidine; D014529:Uridine