Relationships among purine nucleoside metabolism, adenosine triphosphate catabolism, and glycolysis in human erythrocytes.
In human erythrocytes incubated with both naturally occurring purine nucleosides and with a variety of purine nucleoside analogs, ATP catabolism was accelerated and lactate accumulation was increased. Tubercidin was a particularly potent inducer of ATP catabolism. In cells incubated with tubercidin, the major route of adenylate metabolism was deamination, whereas in cells incubated with deoxyglucose, the major pathway was dephosphorylation.
D058892:Adenosine Deaminase Inhibitors; D000255:Adenosine Triphosphate / Q000037:antagonists & inhibitors / Q000378:metabolism*; D003847:Deoxyglucose / Q000494:pharmacology; D004912:Erythrocytes / Q000378:metabolism*; D006019:Glycolysis; D006801:Humans; D007461:Iodoacetates / Q000494:pharmacology; D007773:Lactates / Q000037:antagonists & inhibitors / Q000378:metabolism; D011684:Purine Nucleosides / Q000378:metabolism* / Q000494:pharmacology; D012969:Sodium Fluoride / Q000494:pharmacology; D014372:Tubercidin / Q000494:pharmacology
D058892:Adenosine Deaminase Inhibitors; D007461:Iodoacetates; D007773:Lactates; D011684:Purine Nucleosides; D000255:Adenosine Triphosphate; D012969:Sodium Fluoride; D003847:Deoxyglucose; D014372:Tubercidin