Drug discrimination training with progressively lowered doses.
Rats were trained to discriminate drug from no-drug conditions in a two-lever operant task. Moderately high dosages were used initially. Whenever the discrimination was learned, training was continued with progressively reduced dosages. Eventually the rats discriminated extremely low doses of phenobarbital, chlordiazepoxide, cyclazocine, and fentanyl.
D000818:Animals; D002707:Chlordiazepoxide / Q000494:pharmacology; D003496:Cyclazocine / Q000494:pharmacology; D004193:Discrimination Learning / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D005283:Fentanyl / Q000494:pharmacology; D010600:Pharmacology; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D012601:Scopolamine / Q000494:pharmacology
D002707:Chlordiazepoxide; D012601:Scopolamine; D003496:Cyclazocine; D005283:Fentanyl; D010634:Phenobarbital