title: [Dynamics of bilignost distribution in different exposures of the body in white rats].
abstract: The dynamics of distribution of 125I- and 131I-bilignost in intact rats has been studied in experimental pathological condition of the liver. It has been shown that the cholecystographic radiographic contrast agent (RCA) bilignost is absorbed and accumulated mainly by the liver. This indicates that the preparation elicits a selective action with respect to the liver. Administration of 125I-bilignost in conjunction with the unlabeled cholecystographic agents bilignost and endografin induces competition for absorption by the liver, which distinguishes these preparations from the urographic agent cardiotrast decreasing accumulation of the label by the kidneys. Acute CCl4 poisoning of the animals results in a sharp decrease in the liver capacity for accumulation of 131I-bilignost and to a slight rise in the preparation kidney level. Three-day administration of phenobarbital to rats produces a considerable drop in 125I-bilignost level in all the organs tested, suggesting an enhanced RCA excretion from the body.
mesh_terms: D000208:Acute Disease; D000818:Animals; D001702:Biopharmaceutics; D002252:Carbon Tetrachloride Poisoning / Q000378:metabolism; D003287:Contrast Media / Q000008:administration & dosage; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D007457:Iodine Radioisotopes; D007458:Iodipamide / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D013997:Time Factors; D014018:Tissue Distribution / Q000187:drug effects
chemical_list: D003287:Contrast Media; D007457:Iodine Radioisotopes; D007458:Iodipamide; D010634:Phenobarbital
vernacular_title: Dinamika raspredeleniia bilignosta pri razlichnykh vozdeĭstviiakh na organizm belykh krys.