title: [Evaluation of acute toxic effect of 3-cyanopyridine].
abstract: General acute toxicity, irritating, and allergic effects of 3-cyanpyridine were studied. LD50 after oral administration amounts to 1185 mg/kg of body weight, 3-cyanpyridine is absorbed through the intact skin: administration of 3-cyanpyridine solution into rabbit skin caused death of animals. Histopathologic studies showed reversible liver and kidney injuries after single administration of lethal and sublethal doses. 3-cyanpyridine significantly irritates damaged skin and in a solid state produces an irreversible cornea opacity. Allergic effect was not found.
mesh_terms: D000208:Acute Disease; D058186:Acute Kidney Injury / Q000139:chemically induced*; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007668:Kidney / Q000473:pathology; D007683:Kidney Tubular Necrosis, Acute / Q000139:chemically induced*; D008297:Male; D009570:Nitriles / Q000633:toxicity*; D011725:Pyridines / Q000633:toxicity*; D051381:Rats
chemical_list: D009570:Nitriles; D011725:Pyridines; C020729:3-cyanopyridine
vernacular_title: Ocena ostrego działania toksycznego 3-cyjanopirydyny.