Effect of alpha-chlorohydrin on epididymal sperm and epididymal plasma in swine.
Investigation of the contraceptive mechanism of alpha-chlorohydrin was done by analyses of epididymal plasma and certain epididymal sperm characteristics after oral administration of 0, 5, 10 or 30 mg/kg, day of the drug to boars for 15 days. Water resorption in caput epididymidis was slightly decreased in all treatment groups. Sodium, potassium, chloride, glycerylphosphorylcholine levels, and seminal antigens in epididymal plasma were not altered significantly by 10 or 30 mg/kg of the drug. The boars on 5 mg/kg exhibited significantly elevated sodium, potassium, or chloride values in various segments. Motility was significantly lower on corpus and proximal cauda epididymal spermatozoa from alpha-chlorohydrin treated boars. Only boars receiving 30 mg/kg exhibited impaired sperm motility in the distal cauda. The movement of the cytoplasmic droplets to the distal position was retarded in boars on the two highest dose levels. The results suggest that the contraceptive effects of alpha-chlorohydrin in the boar is probably not mediated via an impaired epididymal function.
D000818:Animals; D000941:Antigens / Q000032:analysis; D002452:Cell Count; D002712:Chlorides / Q000032:analysis; D002728:Chlorohydrins / Q000494:pharmacology*; D003272:Contraceptive Agents, Male / Q000494:pharmacology*; D004822:Epididymis / Q000032:analysis / Q000187:drug effects*; D005997:Glycerylphosphorylcholine / Q000032:analysis; D006801:Humans; D008297:Male; D011188:Potassium / Q000032:analysis; D012661:Semen / Q000276:immunology; D012964:Sodium / Q000032:analysis; D013081:Sperm Motility / Q000187:drug effects; D013094:Spermatozoa / Q000166:cytology / Q000187:drug effects*; D013552:Swine; D000517:alpha-Chlorohydrin / Q000494:pharmacology*
D000941:Antigens; D002712:Chlorides; D002728:Chlorohydrins; D003272:Contraceptive Agents, Male; D005997:Glycerylphosphorylcholine; D000517:alpha-Chlorohydrin; D012964:Sodium; D011188:Potassium