[Supression of the lymphocyte blast transformation reaction evoked in human subjects by a fat load].
It has been shown that "Intralipid"--triglycerides emulsion, used for parenteral feeding, administered intravenously in the amount of 200 ml would induce within 2 hours in human subjects a metabolic immunosuppression, estimated by a drop in the labelled thymidine and uridine incorporation into phytohemagglutinin stimulated lymphocytes. The dosage blood loss (25 ml of blood) would prevent the inhibition of lymphocytic blasttransformation reaction, that seems to prove the functional nature of metabolic immunosuppression, induced by the increased concentration of fatty acids in blood due to hydrolysis of administered triglycerides. The relationship between metabolic immunosuppression and the standard methods of treatment used in oncology is briefly discussed.
D001815:Bloodletting; D004655:Emulsions; D006493:Heparin / Q000008:administration & dosage; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods*; D008213:Lymphocyte Activation / Q000187:drug effects*; D008214:Lymphocytes / Q000378:metabolism; D013936:Thymidine / Q000097:blood; D013997:Time Factors; D014280:Triglycerides / Q000008:administration & dosage*; D014529:Uridine / Q000097:blood
D004655:Emulsions; D014280:Triglycerides; D006493:Heparin; D013936:Thymidine; D014529:Uridine
Ugnetenie reaktsii blasttransformatsii limfotsitov, vyzvannoe u cheloveka zhirovoĭ nagruzkoĭ.