Mutagenicity of N-nitroso pyridinol carbamate with the Salmonella/mammalian microsome test.
Pyridinol carbamate was nitrosated to the N,N1-dinitroso derivative and the structure was proved by spectroscopic methods, including chemical ionization mass spectroscopy. By the Ames test, the dinitroso derivative showed a significant dose-dependent mutagenic response with Salmonella typhimurium strains TA 1535 and TA 100; the response became more pronounced in the presence of microsomes. As the dosage of N-nitroso pyridinol carbamate increased, the number of revertant colonies also increased. Pyridinol carbamate was not mutagenic.
D000818:Animals; D002219:Carbamates / Q000031:analogs & derivatives; D004353:Drug Evaluation, Preclinical; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D009153:Mutagens; D009602:Nitrosamines / Q000494:pharmacology*; D011727:Pyridinolcarbamate / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology; D051381:Rats
D002219:Carbamates; D009153:Mutagens; D009602:Nitrosamines; D011727:Pyridinolcarbamate