Evaluation of mebendazole for the treatment of trichuriasis.
Trichuris trichiura was found to cause severe refractory clinical illness in 25 child patients admitted to a rural hospital in northeast Queensland over a six-month period. Mebendazole produced significant alleviation of symptoms. Symptomless carrier states in 70 patients admitted to hospital for other complaints were also studied. Thirty-five of these were treated with mebendazole with a notable reduction in worm loads (as measured by Stoll egg counts) when compared with the control group. The effects of three-day and four-day courses of mebendazole on symptomless carriers are compared.
D001562:Benzimidazoles / Q000627:therapeutic use*; D002353:Carrier State / Q000188:drug therapy; D002648:Child; D004341:Drug Evaluation; D005243:Feces / Q000469:parasitology; D006801:Humans; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy*; D008463:Mebendazole / Q000627:therapeutic use*; D010270:Parasite Egg Count; D014257:Trichuriasis / Q000188:drug therapy*
D001562:Benzimidazoles; D008463:Mebendazole