title: Angiotensin II in primary hypertension, relationship to plasma renin activity, aldosterone and urinary electrolytes.
abstract: Plasma concentrations of angiotensin II (AII) were studied in 36 patients with primary (essential) hypertension and 15 normotensive control subjects during basal (1 h supine rest), upright and frusemide-stimulated (80 mg orally) conditions. Plasma renin activity (PRA) and plasma aldosterone (PA) were determined on the same occasions. AII was then correlated statistically to PRA, PA and 24-hour urinary excretions of aldosterone (Aldo-U), sodium and potassium and to the blood pressure (BP) levels. The AII values in the hypertensive patients were not statistically significantly different from those in the normotensive subjects. A close relationship was found between the AII values and the corresponding PRA values in the hypertensive patients (r=0.65--0.76, p less than 0.001 for all). Correlations between AII and PA, and AII and Aldo-U were not consistently significant. No correlation was found between AII and BP or between AII and 24-hour urinary electrolytes. The findings point to an intact function between PRA and AII but a disturbed AII-aldosterone interrelation in primary hypertension.
mesh_terms: D000328:Adult; D000368:Aged; D000450:Aldosterone / Q000097:blood / Q000502:physiology*; D000804:Angiotensin II / Q000097:blood / Q000502:physiology*; D001835:Body Weight; D003404:Creatinine / Q000097:blood; D004573:Electrolytes / Q000378:metabolism / Q000652:urine*; D005260:Female; D005665:Furosemide; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011187:Posture; D011674:Pulse; D012083:Renin / Q000097:blood / Q000502:physiology*
chemical_list: D004573:Electrolytes; D000804:Angiotensin II; D000450:Aldosterone; D005665:Furosemide; D003404:Creatinine; D012083:Renin