Epoxides as products of lipid autoxidation in rat lungs.
The nature and content of lipid epoxides in rat lung were examined in air-breathing control rats and those exposed to nitrogen dioxide. Exposure to 6.5 ppm NO2 for 24 hr resulted in significantly greater epoxide content in a number of lipid classes. It is proposed that lipid autoxidation in lung tissues may contribute to the levels of epoxide-containing lipids. Furthermore, the processes involved in epoxide formation may be predicted from autoxidation studies utilizing a system of unsaturated fatty acid monolayers on silica gel which serves as a model for biomembranes. The findings indicate that exposure to oxidizing gases can lead to an accumulation of lipid epoxides in both lung parenchymal tissue and on the alveolar surface.
D000818:Animals; D002784:Cholesterol / Q000378:metabolism; D004851:Epoxide Hydrolases / Q000378:metabolism; D004852:Epoxy Compounds / Q000378:metabolism*; D004988:Ethers, Cyclic / Q000378:metabolism*; D005227:Fatty Acids / Q000032:analysis; D050356:Lipid Metabolism; D008168:Lung / Q000378:metabolism*; D008297:Male; D009585:Nitrogen Dioxide; D010084:Oxidation-Reduction; D051381:Rats
D004852:Epoxy Compounds; D004988:Ethers, Cyclic; D005227:Fatty Acids; D002784:Cholesterol; D004851:Epoxide Hydrolases; D009585:Nitrogen Dioxide