Auditory function in guinea pigs treated with netilmicin and other aminoglycoside antibiotics.
The following aminoglycoside antibiotics netilmicin, sisomicin, gentamicin, and kanamycin were submitted to a comparative study of their ototoxicity using both reflexological (Preyer's pinnareflex) and electrophysiological (near and far field) methods. The daily s.c. administration of sisomicin, gentamicin, and kanamycin for 21 days provoked a dose-related impairment of the cochlear function, detected with all the employed techniques. On the other hand, a very low ototoxic effect of netilmicin was demonstrated with electrophysiological but not with the reflexological evaluation. The reliability of the methods used in these experiments is also compared.
D000200:Action Potentials / Q000187:drug effects; D000617:Aminoglycosides / Q000633:toxicity*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000633:toxicity*; D003051:Cochlea / Q000187:drug effects* / Q000473:pathology; D005260:Female; D006168:Guinea Pigs; D008297:Male; D009428:Netilmicin / Q000633:toxicity
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D009428:Netilmicin