Cimetidine and salbutamol combined inhibition of gastric acid secretion in the dog.
The effects of salbutamol and cimetidine, alone and in combination, on pentagastrin-stimulated gastric secretion have been studied in conscious dogs with gastric fistulae. Salbutamol 24 nmol/kg.h alone and cimetidine 4 mumol/kg.h alone inhibited acid up to 69%, cimetidine 8 mumol/kg.h produced up to 87% inhibition and the combination of cimetidine 4 mumol/kg.h and salbutamol 24 nmol/kg.h almost totally inhibited acid (up to 99%). The pharmacokinetics of these inhibitions were studied and salbutamol and/or cimetidine caused a complex uncompetitive inhibition of pentagastrin-stimulated acid. The inhibitory combination of the two drugs was additive.
D000420:Albuterol / Q000494:pharmacology*; D000818:Animals; D002927:Cimetidine / Q000494:pharmacology*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D005750:Gastric Juice / Q000378:metabolism*; D006146:Guanidines / Q000494:pharmacology*; D010418:Pentagastrin; D012636:Secretory Rate / Q000187:drug effects
D006146:Guanidines; D002927:Cimetidine; D010418:Pentagastrin; D000420:Albuterol