title: Effects of dextranases on attachment of Streptococcus mutans to hydroxyapatite.
abstract: A Fusarium dextranase and a Penicillium dextranase were compared for their relative ability to quantitatively reduce the adsorption of (3)H-labeled Steptococcus mutans cells onto hydroxyapatite. Fusarium dextranase-treated hydroxyapatite disks caused a statistically significant decrease in the hydroxyapatite adsorption of both the OMZ 176 and NCTC 10449 strains of S. mutans relative to untreated control disks. The extent of initial bacterial adsorption was not promoted by sucrose-dependent glucan synthesis. Since the Fusarium dextranase has a much greater affinity for hydroxyapatite than the Penicillium dextranase, it could represent an enzyme with improved decay-preventive therapeutic properties. This was concluded because the Fusarium dextranase may interfere with both the initial attachment and later glucan-dependent accumulation of dental plaque microorganisms.
mesh_terms: D000268:Adhesiveness; D000327:Adsorption; D003910:Dextranase / Q000494:pharmacology*; D005670:Fusarium / Q000201:enzymology; D006882:Hydroxyapatites / Q000378:metabolism*; D010407:Penicillium / Q000201:enzymology; D013045:Species Specificity; D013295:Streptococcus mutans / Q000187:drug effects* / Q000502:physiology
chemical_list: D006882:Hydroxyapatites; D003910:Dextranase