title: MMPI and drug treatment in alcohol withdrawal.
abstract: Thirty-four inpatients in a mild phase of alcohol withdrawal, exhibiting anxious and depressive symptoms, were administered an MMPI before and immediately after a 4-week drug treatment period. A double-blind design was used; 17 patients were treated with chlordiazepoxide and 17, with thioridazine. The pretreatment MMPI profile was typical of alcoholic patients; namely, peaks on scales 4 and 2. After the fourth week, the MMPI indicated that thioridazine was significantly more effective than chlordizaepoxide. Decreases in 7 of the 10 clinical scales averaged 7.29 T-score points, whereas only scale 6 was significantly decreased for the patients treated with chlordiazepoxide.
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000523:psychology*; D002707:Chlordiazepoxide / Q000627:therapeutic use*; D004311:Double-Blind Method; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008950:MMPI; D008297:Male; D008875:Middle Aged; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy / Q000523:psychology*; D013881:Thioridazine / Q000627:therapeutic use*
chemical_list: D002707:Chlordiazepoxide; D013881:Thioridazine