title: Influence of enteric parasitism on hormone-regulated pancreatic secretion in dogs.
abstract: The objective of this study was to test the hypothesis that enteric parasites affect pancreatic secretion in their host. Pancreatic bicarbonate and protein outputs were studied in dogs with gastric and pancreatic fistulas to determine the secretory response to exogenously administered secretin and cholecystokinin and to intraduodenal stimulation with hydrochloric acid and sodium oleate to release endogenous hormones. Bicarbonate and protein concentrations in pancreatic juice were measured prior to infection with Trichinella spiralis and at various periods during primary and secondary infections. Dose-related increases in secretory activity were observed in uninfected hosts in response to all stimuli. Infected dogs responded like controls to exogenous hormones, but showed reduced secretion under duodenal stimulation during the 1st wk of primary infection. This altered response returned to normal 3 wk after primary infection and did not occur following secondary infection. Results support the conclusion that reduced pancreatic secretion is associated with enteric parasitism and is due to a defect in hormone release or in the supply of hormone available for release.
mesh_terms: D000818:Animals; D001639:Bicarbonates / Q000378:metabolism*; D002766:Cholecystokinin / Q000494:pharmacology; D004285:Dogs; D006851:Hydrochloric Acid / Q000494:pharmacology; D009829:Oleic Acids / Q000494:pharmacology; D010179:Pancreas / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D012633:Secretin / Q000494:pharmacology; D014235:Trichinellosis / Q000503:physiopathology*
chemical_list: D001639:Bicarbonates; D009829:Oleic Acids; D011506:Proteins; D012633:Secretin; D002766:Cholecystokinin; D006851:Hydrochloric Acid