Effects of modern loop diuretics on the inner ear a quantitative evaluation using computer technics.
The effects of some modern high ceiling loop diuretics on the guinea-pig's inner ear are tested. Short-time experiments are run registrating the cochlear microphonic potentials (CMP) before and after i.v. bolus injections of a diuretic. A 100-point matrix program is performed by automatic sampling of the CMPs after stimulating by five frequencies at 20 sound pressure levels each. Data can be plotted in different scales within 10 min after the end of a whole-day experiment. The data are on-line processed by a IBM 1800 computer.
D000818:Animals; D002034:Bumetanide / Q000009:adverse effects; D003051:Cochlea / Q000187:drug effects*; D004232:Diuretics / Q000009:adverse effects*; D004976:Ethacrynic Acid / Q000009:adverse effects; D005072:Evoked Potentials, Auditory / Q000187:drug effects; D005665:Furosemide / Q000009:adverse effects; D006168:Guinea Pigs; D009862:Online Systems
D004232:Diuretics; D002034:Bumetanide; D005665:Furosemide; D004976:Ethacrynic Acid