title: Intranuclear particles in keratoacanthoma: possible association with malignant degeneration.
abstract: Electron microscopic investigation of 12 patients with keratoacanthoma is reported. Intranuclear virus-like particles, as described by Zelickson and Lynch, were seen in 3 cases; 2 of these subsequently underwent malignant degeneration. These findings suggest that it is particularly important to exclude the possibility of malignant change in those tumours when intranuclear particles are found.
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000209:etiology* / Q000648:ultrastructure; D002466:Cell Nucleolus / Q000648:ultrastructure; D006801:Humans; D007636:Keratoacanthoma / Q000150:complications / Q000473:pathology*; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D012867:Skin / Q000648:ultrastructure*; D012878:Skin Neoplasms / Q000209:etiology* / Q000648:ultrastructure