Meiotic maturation in Xenopus laevis oocytes initiated by insulin.
Insulin can induce meiotic division in Xenopus laevis oocytes. This effect shows the specificity expected of a receptor-mediated mechanism. It is potentiated by ethynylestradiol, a steroid antagonist of pregesterone (the natural hormone that provokes meiosis). The Xenopus laevis oocytes may serve as a model for the study of the poorly understood effect of insulin on cell division.
D000818:Animals; D002118:Calcium / Q000502:physiology; D002772:Cholera Toxin / Q000494:pharmacology; D003513:Cycloheximide / Q000494:pharmacology; D004997:Ethinyl Estradiol / Q000494:pharmacology; D005260:Female; D007328:Insulin / Q000494:pharmacology*; D007700:Kinetics; D008540:Meiosis / Q000187:drug effects*; D009865:Oocytes / Q000187:drug effects*; D009866:Oogenesis / Q000187:drug effects*; D010063:Ovum / Q000187:drug effects*; D011374:Progesterone / Q000494:pharmacology; D011972:Receptor, Insulin / Q000187:drug effects; D014981:Xenopus
D007328:Insulin; D004997:Ethinyl Estradiol; D011374:Progesterone; D002772:Cholera Toxin; D003513:Cycloheximide; D011972:Receptor, Insulin; D002118:Calcium