Schedule-induced drinking and thirst: a pharmacological analysis.
Similar levels of water consumption were induced in two groups of rats by means either of prior fluid deprivation or a schedule of food pellet delivery. Injections of d-amphetamine (0.25, 0.5, 1.0 and 2.0 mg/kg) had similar attenuating effects of drinking induced by both procedures. Chlordiazepoxide (2.5, 5.0, 10 and 20 mg/kg), however, exerted differential actions on schedule-induced and deprivation-induced drinking. Drinking induced by deprivation was facilitated by all doses of this drug while the higher doses decreased levels of schedule-induced drinking. This result emphasises the difficulties involved in using the concept of thirst in explanations of behavior and of drug action.
D000818:Animals; D002707:Chlordiazepoxide / Q000494:pharmacology; D003216:Conditioning, Operant / Q000187:drug effects*; D003913:Dextroamphetamine / Q000494:pharmacology; D004327:Drinking Behavior / Q000187:drug effects*; D005260:Female; D051381:Rats; D012055:Reinforcement Schedule; D013894:Thirst / Q000187:drug effects*; D014868:Water Deprivation
D002707:Chlordiazepoxide; D003913:Dextroamphetamine