Pregnancy-associated disease of the renal microcirculation.
1. Platelet factor 3, platelet survival, renal platelet localization and fibrinolytic activity have been studied in normotensive subjects with a previous history of pregnancy-associated hypertension. Studies were carried out up to 6 years after the complicated pregnancy. 2. Renal platelet localization was found to be significantly increased despite normal platelet survival and platelet factor 3 availability. Significant impairment of both resting and post-venous-occlusion fibrinolytic activity was also demonstrable. 3. The significance of these findings in relation to mediation of progressive intrarenal vascular disease is discussed.
D000328:Adult; D001792:Blood Platelets / Q000502:physiology; D005260:Female; D005342:Fibrinolysis; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D007668:Kidney / Q000503:physiopathology; D008055:Lipids / Q000097:blood; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000503:physiopathology; D011250:Pregnancy Complications, Hematologic / Q000503:physiopathology*; D013925:Thromboplastin / Q000032:analysis
D008055:Lipids; D013925:Thromboplastin