[Experimental data to substantiate the antitumor action of hydrazine sulfate].
It was found that under the influence of hydrazine sulfate, which in the dosage of 60 mg/kg would induce a 50% suppression of Walker carcinosarcoma in rats, there is the decreased activity of mitochondrial monoamine oxidase and a sharp reduction in the activity of some microsomal phosphatases. Vitamin B6 injection some hours before injecting hydrazine sulfate lessens the rate of suppression of the tumor growth up to 50%. The results obtained indicate that the antitumor effect of hydrazine sulfate may be related to the suppressed monoamine oxidate activity and vitamin B6 deficiency.
D000818:Animals; D000970:Antineoplastic Agents; D002279:Carcinoma 256, Walker / Q000188:drug therapy / Q000201:enzymology; D004353:Drug Evaluation, Preclinical; D004789:Enzyme Activation / Q000187:drug effects; D006834:Hydrazines / Q000008:administration & dosage / Q000627:therapeutic use*; D009368:Neoplasm Transplantation; D051381:Rats; D013997:Time Factors; D026681:Vitamin B 6 Deficiency / Q000201:enzymology
D000970:Antineoplastic Agents; D006834:Hydrazines
Eksperimental'nye dannye k obosnovaniiu protivoopukholevogo deĭstviia gidrazinsul'fata.