Influence of R-805 on the contractility and reactivity of rat myometrium.
It has been found that R-805 reduces and then eliminates the contractile activity of the isolated rat myometrium. R-805 weakens and then abolishes the reaction of the myometrium to polypeptides (oxytocin, vasopressin, bradykinin and hypertensin). In the presence of R-805, exogenous prostaglandin F(2) alpha restores the myometrial reactivity to the investigated polypeptides. On the basis of the obtained results and data from the literature a tentative hypothesis has been put forward as to the mechanism of R-805 action on the myometrial reactivity to polypeptides.
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001920:Bradykinin / Q000494:pharmacology; D004347:Drug Interactions; D005260:Female; D066298:In Vitro Techniques; D010121:Oxytocin / Q000494:pharmacology; D011460:Prostaglandins F / Q000494:pharmacology; D051381:Rats; D013449:Sulfonamides / Q000494:pharmacology*; D014590:Uterine Contraction / Q000187:drug effects*; D014667:Vasopressins / Q000494:pharmacology
D000893:Anti-Inflammatory Agents; D011460:Prostaglandins F; D013449:Sulfonamides; D014667:Vasopressins; D000804:Angiotensin II; D010121:Oxytocin; D001920:Bradykinin