[Effect of the alkylating agent dipin on the induced proliferation of hepatocytes. I. The kinetics of the cell population].
The alkylating drug dipin was injected to mice 2 hours before a partial hepatectomy. Liver regeneration was characterized by a decrease of the intensity of 3H-thymidine label, an increase of the labeled cell index, absence of mitoses, constant number of binuclear cells. The analysis of these data has shown that dipin causes a sharp (more than by 2 times) increase of the S-period and prolonged (up to 6--20 days) blocking of cells in the G2-period. No phenomenon of unbalanced growth was recorded. No changes in duration of prereplicative period, or in the volume of proliferative pool were recorded. The increase of mitotic cycle periods resulted in the cell population synchronization: by the end of the second ay more than a half of hepatocytes were in S-period, by the end of the third day about 80% of cells passed to G2-period.
D000477:Alkylating Agents / Q000494:pharmacology*; D000818:Animals; D001388:Aziridines / Q000494:pharmacology*; D001389:Azirines / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis; D006498:Hepatectomy; D007399:Interphase / Q000187:drug effects; D007700:Kinetics; D008099:Liver / Q000166:cytology / Q000187:drug effects*; D008115:Liver Regeneration / Q000187:drug effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008938:Mitosis / Q000187:drug effects; D010879:Piperazines / Q000494:pharmacology; D013997:Time Factors
D000477:Alkylating Agents; D001388:Aziridines; D001389:Azirines; D010879:Piperazines; D004247:DNA
Vliianie alkiliruiushchego agenta dipina na indutsirovannuiu proliferatsiiu gepatotsitov. I. Kinetika kletochnoĭ populiatsii.