title: Representation of Nonepistatic selection models and analysis of multilocus Hardy-Weinberg Equilibrium configurations.
abstract: The paper develops conditions for the existence and the stability of central equilibria emanating from selection recombination interaction with generalized nonepistatic selection forms operating in multilocus multiallele systems. The selection structure admits a natural representation as simple sums of Kronecker products based on a common set of marginal selection components. A flexible parametrization of the recombination process is introduced leading to a canonical derivation of the transformation equations connecting gamete frequency states over successive generations. Conditions for the existence and stability of multilocus Hardy-Weinberg (H.W.) type equilibria are elaborated for the classical nonepistatic models (multiplicative and additive viability effects across loci) as well as for generalized nonepistatic selection expressions. It is established that the range of recombination distributions maintaining a stable H.W. polymorphic equilibrium is confined to loose linkage in the pure multiplicative case, but is not restricted in the additive model. In the bisexual case we ascertain for the generalized nonepistatic model the stability conditions of a common H.W polymorphism.
mesh_terms: D000483:Alleles; D002874:Chromosome Mapping; D004843:Epistasis, Genetic; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008433:Mathematics; D008954:Models, Biological; D011110:Polymorphism, Genetic; D011995:Recombination, Genetic; D012641:Selection, Genetic; D012730:Sex Chromosomes; D012737:Sex Factors