Shape change reaction of platelets in protein-free medium: ultramorphology.
Transmission and scanning electron microscopy indicate that rabbit platelets incubated in protein-poor medium retain their reactivity to shape change-inducing agents such as 5-hydroxytryptamine, adenosine-5'-diphosphate and chlorpromazine. Such platelets may be used as models for drug-membrane interactions, e.g. in neuronal cells.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D001792:Blood Platelets / Q000187:drug effects / Q000648:ultrastructure*; D002462:Cell Membrane / Q000187:drug effects / Q000648:ultrastructure; D002746:Chlorpromazine / Q000494:pharmacology; D003470:Culture Media; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D011817:Rabbits; D011955:Receptors, Drug / Q000187:drug effects; D012701:Serotonin / Q000494:pharmacology
D003470:Culture Media; D011955:Receptors, Drug; D012701:Serotonin; D000244:Adenosine Diphosphate; D002746:Chlorpromazine