Effects on muscle electrolytes of potassium and magnesium infusions, spironolactone medication and operation in a case of primary aldosteronism.
Serum and muscle electrolytes were determined in a case of primary aldosteronism before and after potassium and magnesium infusions as well as spironolactone treatment and following surgery. Repeated potassium infusions resulted in a transient normalization of the muscle potassium (K/m), followed within 3-4 days by a return to the previously low K/m. Magnesium infusions did not give any increase in muscle magnesium (Mg/m). On the contrary, there was a decrease in Mg/m concomitant with a decrease in K/m. Treatment with spironolactone for one month was followed by a normalization of both serum and muscle electrolytes. Following surgery the serum potassium and K/m remained normal, but the serum magnesium (Mg/s) and Mg/m showed a decrease to subnormal values. Despite the initial findings of normal Mg/s and Mg/m as well as excretion of more than 80% of the i.v. magnesium dose, this may indicate that there was a magnesium deficiency in the skeletal pool.
D005260:Female; D006801:Humans; D006929:Hyperaldosteronism / Q000188:drug therapy / Q000378:metabolism*; D007263:Infusions, Parenteral; D008274:Magnesium / Q000008:administration & dosage / Q000378:metabolism* / Q000627:therapeutic use; D008275:Magnesium Deficiency / Q000150:complications* / Q000188:drug therapy; D008564:Membrane Potentials; D008875:Middle Aged; D009132:Muscles / Q000378:metabolism*; D011188:Potassium / Q000008:administration & dosage / Q000378:metabolism* / Q000627:therapeutic use; D013148:Spironolactone / Q000627:therapeutic use*
D013148:Spironolactone; D008274:Magnesium; D011188:Potassium