Identification of benzhydrol as a urinary metabolite of diphenylmethane in the rat.
Liquid-liquid extraction and preparative thin-layer chromatography were used to isolate 30 micromoles of benzhydrol from the beta-glucuronidase treated 24 hour urine of rats administered 5.3 mmoles of diphenylmethane. The benzhydrol was identified by its melting point, elemental analysis, infrared, nuclear magnetic resonance, and mass spectra.
D000818:Animals; D001559:Benzhydryl Compounds / Q000652:urine*; D001711:Biotransformation; D006868:Hydrolysis; D006900:Hydroxylation; D008297:Male; D051381:Rats
D001559:Benzhydryl Compounds; C020225:benzohydrol