Effects of genetic vestibular defects on behavior related to spatial orientation and emotionality.
A large battery of behavioral tests was administered to normal mice and to mice with varying degrees of otoconial agenesis due to genes affecting vestibular development. Many significant differences were found, but a factor analysis revealed that the variance on the 11 best tests could be accounted for in terms of two underlying variables. Factor I, the more important of the two, was associated with activity, habituation, and spontaneous alternation. Factor II appeared to represent a fear of new stimuli or situations. In both cases factor scores were highly related to the degree of otoconial deficiency. One subgroup of mice with severe otoconial agenesis displayed hyperactivity and a total absence of either habituation or spontaneous alternation. In these animals, brain and body development were stunted, and the reactions to amphetamine and physostigmine were opposite to those seen in normal mice. The results support the idea that the static organs contribute importantly to spatial orientation and suggest that early-onset vestibular defects can result in profound alterations of emotionality.
D000109:Acetylcholine / Q000502:physiology; D000818:Animals; D002531:Cerebellum / Q000502:physiology; D003657:Decision Making / Q000502:physiology; D007758:Ear, Inner / Q000502:physiology*; D004644:Emotions / Q000502:physiology*; D005163:Factor Analysis, Statistical; D006185:Habituation, Psychophysiologic / Q000502:physiology; D006624:Hippocampus / Q000502:physiology; D051379:Mice; D009949:Orientation / Q000502:physiology*; D012444:Saccule and Utricle / Q000502:physiology*; D013028:Space Perception / Q000502:physiology*
D000109:Acetylcholine