Serum gonadotrophin levels in prepubertally castrated male sheep treated for long periods with propionated testosterone, dihydrotestosterone, 19-hydroxytestosterone or oestradiol.
At different times of the year, groups of wethers were treated with 20 mg testosterone, dihydrotestosterone or 19-hydroxytestosterone propionates/day or 2 mg oestradiol dipropionate/day, or the oil vehicle, for 6 weeks after a 2-week control period. LH and FSH values were determined by radioimmunoassay of serum samples collected at regular intervals. Oestradiol and dihydrotestosterone reduced LH and FSH concentrations whereas 19-hydroxytestosterone and testosterone had no effect.
D000818:Animals; D002369:Castration; D013196:Dihydrotestosterone / Q000494:pharmacology*; D004958:Estradiol / Q000494:pharmacology*; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006915:Hydroxytestosterones / Q000494:pharmacology; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D011863:Radioimmunoassay; D012621:Seasons; D012741:Sexual Maturation; D012756:Sheep; D013739:Testosterone / Q000494:pharmacology*
D006915:Hydroxytestosterones; D013196:Dihydrotestosterone; D013739:Testosterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone