Influence of thyroid hormones on collagen content in tissues of guinea pigs.
Collagen fractions content and level of collagen catabolites in body fluids were determined in normal, hypo- and hyperthyroid guinea pigs. An increase of urinary excretion of hydroxyproline and hydroxylysine as well as concentration of these amino acids in blood serum was found in hyperthyroidism, and a decrease was shown in hyperthyroid guinea pigs. Hyperthyroidism stimulated an increase of neutral-salt-soluble and acid-soluble collagen in skin and liver, and a decrease of insoluble collagen in skin as well as increase of all collagen fractions in bone samples. Hypothyroidism induced a decrease of all collagen fractions in skin and liver, and an increase of acid-soluble and insoluble collagen in bone samples.
D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D003094:Collagen / Q000378:metabolism*; D006168:Guinea Pigs; D006901:Hydroxylysine / Q000652:urine; D006909:Hydroxyproline / Q000652:urine; D006980:Hyperthyroidism / Q000378:metabolism*; D007037:Hypothyroidism / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D012867:Skin / Q000378:metabolism; D013961:Thyroid Gland / Q000503:physiopathology; D013963:Thyroid Hormones / Q000502:physiology*
D013963:Thyroid Hormones; D006901:Hydroxylysine; D003094:Collagen; D006909:Hydroxyproline