title: [Bioavailability of peroral drug forms of oxacillin].
abstract: Bioavailability of experimental tablets and capsules of oxacillin was studied. Significant differences in absorption of the antibiotic from the above dosage forms were found. By the amount of the antibiotic absorbed the capsules were 3 times more effective than the tablets containing the same amount of oxacillin. The therapeutic concentrations of oxacillin in the blood after the use of the capsules persisted by an hour longer than after the use of the tablets. The results of the study on oxacillin absorption in rabbits allowed a prediction of the antibiotic absorption levels in humans.
mesh_terms: D000042:Absorption; D000284:Administration, Oral; D000328:Adult; D000818:Animals; D001682:Biological Availability; D002214:Capsules; D005069:Evaluation Studies as Topic; D006801:Humans; D010068:Oxacillin / Q000097:blood*; D011817:Rabbits; D013607:Tablets; D013810:Therapeutic Equivalency; D013997:Time Factors
chemical_list: D002214:Capsules; D013607:Tablets; D010068:Oxacillin
vernacular_title: Biodostupnost' peroral'nykh lekarstvennykh form oksatsillina.