Cannabinoid inhibition of rat luteal cell progesterone synthesis.
Progesterone production by isolated rat luteal cells was inhibited by exposure to various cannabinoids in concentrations from 3.0--16.0 microM. The available evidence points to the cleavage of cholesterol esters as the site of inhibition.
D000818:Animals; D002186:Cannabinoids / Q000494:pharmacology*; D003338:Corpus Luteum / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D013759:Dronabinol / Q000494:pharmacology; D005260:Female; D010053:Ovary / Q000187:drug effects / Q000378:metabolism; D011374:Progesterone / Q000096:biosynthesis*; D051381:Rats; D002787:Sterol Esterase / Q000378:metabolism
D002186:Cannabinoids; D011374:Progesterone; D013759:Dronabinol; D002787:Sterol Esterase