Anti-inflammatory action following liver damage in the rat.
A high molecular weight protein fraction, obtained by column chromatography of saline extracts of the livers of rats that had previously been treated with dimethylnitrosamine, was found to have anti-inflammatory activity against carrageenin induced inflammation in the rat. Evidence was presented that the anti-inflammatory activity may be due to a protein fragment produced by proteolysis of a larger molecule.
D000818:Animals; D001169:Arthritis, Experimental / Q000503:physiopathology; D001798:Blood Proteins / Q000378:metabolism; D002351:Carrageenan; D056486:Chemical and Drug Induced Liver Injury; D002850:Chromatography, Gel; D004128:Dimethylnitrosamine / Q000494:pharmacology; D004487:Edema / Q000139:chemically induced / Q000503:physiopathology; D007249:Inflammation / Q000150:complications / Q000503:physiopathology*; D008107:Liver Diseases / Q000150:complications / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D008970:Molecular Weight; D011480:Protease Inhibitors / Q000097:blood; D011506:Proteins / Q000378:metabolism / Q000502:physiology*; D051381:Rats
D001798:Blood Proteins; D011480:Protease Inhibitors; D011506:Proteins; D002351:Carrageenan; D004128:Dimethylnitrosamine