Coenzyme Q10 or alpha-tocopherol reduce the acute toxicity of anthramycin in mice.
Pretreatment for 4 days with 10 mg/kg coenzyme Q10 (CoQ) or 1 day with 85U alpha-tocopherol (Vit E) produced equal reduction in the acute toxicity of 0.5 mg/kg anthramycin (ANTH). Twenty-seven days after ANTH, 40 percent of control mice survived, those pretreated with CoQ or Vit E displayed 73 and 80 percent survival. A 17.5 mg/kg dose of adriamycin (ADR) produced a percent survival-time curve resembling that produced by 0.5 mg/kg ANTH. At this dose of ADR, however, the protection afforded by CoQ and Vit E was minimal and not statistically significant (p less than 0.05). CoQ or Vit E may be of value at reducing the toxicity of anticancer agents other than the anthracyclines.
D000818:Animals; D000876:Anthramycin / Q000037:antagonists & inhibitors* / Q000633:toxicity; D001570:Benzodiazepinones / Q000037:antagonists & inhibitors*; D004317:Doxorubicin / Q000494:pharmacology; D008297:Male; D051379:Mice; D013997:Time Factors; D014451:Ubiquinone / Q000494:pharmacology*; D014810:Vitamin E / Q000494:pharmacology*
D001570:Benzodiazepinones; D000876:Anthramycin; D014451:Ubiquinone; D014810:Vitamin E; D004317:Doxorubicin