title: Inhibition of Tamm-Horsfall glycoprotein induction of alkaline phosphatase in cystic fibrosis fibroblasts by medium conditioned by normal cells.
abstract: It is confirmed that the level of alkaline phosphatase in fibroblasts derived from cystic fibrosis patients can be induced many-fold by growing the cells in the presence of Tamm-Horsfall glycoprotein. It is further shown that normal fibroblasts produce a "CF corrective factor" which markedly inhibits this phenomenon. These observations support a previous hypothesis on the nature of the metabolic defect in cystic fibrosis.
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism*; D002478:Cells, Cultured / Q000378:metabolism*; D003470:Culture Media; D003550:Cystic Fibrosis / Q000201:enzymology / Q000378:metabolism*; D005347:Fibroblasts / Q000378:metabolism*; D006023:Glycoproteins / Q000494:pharmacology*; D006801:Humans; D013997:Time Factors
chemical_list: D003470:Culture Media; D006023:Glycoproteins; D000469:Alkaline Phosphatase