Anaphylactoid reaction to mannitol.
A 16-year old boy with a lesion of the right eye developed, during the preoperative administration of a mannitol infusion, an anaphylactoid reaction characterized by hypotension, periorbital oedema and bronchospasm. This quickly resolved following cessation of the infusion and appropriate therapeutic measures. There were no long-lasting effects. We considered mannitol the causative agent because of its temporal relationship to the reaction and our inability to seriously implicate any other medication. A history of childhood atopy may have been a predisposing factor.
D000293:Adolescent; D000707:Anaphylaxis / Q000139:chemically induced*; D004342:Drug Hypersensitivity / Q000209:etiology*; D004487:Edema / Q000139:chemically induced; D005134:Eye Neoplasms / Q000601:surgery; D006801:Humans; D008297:Male; D008353:Mannitol / Q000009:adverse effects*; D008545:Melanoma / Q000601:surgery; D012131:Respiratory Insufficiency / Q000139:chemically induced
D008353:Mannitol