Effects of diethylcholine in two animal models of Parkinsonism tremors.
(2-Hydroxyethyl) methyldiethylammonium iodide (diethylcholine; DEC) was tested against trihexyphenidyl for its ability to block tremors in two animal models of Parkinsonism tremors. Both DEC (75 mg/kg) and trihexyphenidyl (10 mg/kg) antagonized physostigmine tremors in mice. Both drugs also blocked tremors in rats which received intracaudate injections of carbachol. DEC was more efficacious than trihexyphenidyl in the rat model. No dose-related inhibition of tremors was seen for trihexyphenidyl (5--20 mg/kg) but inhibition by DEC was dose-related (25--50 mg/kg). The ED50 for tremor inhibition in the rat model by DEC was 33 mg/kg. DEC was also shown to cross the blood-brain barrier in mice. The probable mechanism of action of DEC is discussed.
D000818:Animals; D001923:Brain Chemistry; D002217:Carbachol; D002794:Choline / Q000031:analogs & derivatives* / Q000032:analysis / Q000097:blood / Q000627:therapeutic use; D004195:Disease Models, Animal; D008297:Male; D051379:Mice; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000188:drug therapy*; D010830:Physostigmine; D051381:Rats; D014282:Trihexyphenidyl / Q000627:therapeutic use
D014282:Trihexyphenidyl; D002217:Carbachol; D010830:Physostigmine; D002794:Choline