Simultaneous correction of Ca deficiency and acidosis in fasting obese patients as a prevention of bone demineralisation.
Short-term starvation in the obese induces metabolic acidosis and increased calciuria resulting in severe negative Ca balance. Oral administration of 5 g Ca-lactate daily is capable of correcting acidosis, reducing calciuria and providing the body with 650 mg Ca daily, thereby maintaining a positive Ca balance throughout the period of starvation. We therefore propose administering this amount of the preparation to obese individuals during starvation as a simple and cheap preventive measure against bone demineralisation.
D000138:Acidosis / Q000188:drug therapy / Q000209:etiology*; D000328:Adult; D001851:Bone Diseases, Metabolic / Q000517:prevention & control*; D001842:Bone and Bones / Q000378:metabolism*; D002118:Calcium / Q000627:therapeutic use* / Q000652:urine; D005215:Fasting / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006996:Hypocalcemia / Q000188:drug therapy / Q000209:etiology*; D007773:Lactates / Q000627:therapeutic use; D008875:Middle Aged; D008903:Minerals / Q000378:metabolism*; D009765:Obesity / Q000178:diet therapy* / Q000378:metabolism
D007773:Lactates; D008903:Minerals; D002118:Calcium