Dissimilar effects of lithium isotopes on motility in rats.
Male Wistar rats were injected twice daily with chlorides of pure lithium isotopes, either Li-6 or Li-7. While both salts decreased mobility, the salt of Li-6 initially produced a more profound effect than the salt of Li-7. This differential effect of the isotopes proved to be time dependent and was most evident on the third day of treatment. Li-6 is likely to become a valuable tool in basic psychopharmacological research. It may possess therapeutic and/or toxic properties that are different from those of lithium salts currently used in treatment of mania.
D000818:Animals; D004912:Erythrocytes / Q000378:metabolism; D007554:Isotopes; D008094:Lithium / Q000097:blood / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D013997:Time Factors
D007554:Isotopes; D008094:Lithium