title: Oxfendazole--anthelmintic activity in Egyptian goats artificially infected with gastrointestinal nematodes.
abstract: The recently developed benzimidazole anthelmintic, oxfendazole, was tested against artificial nematode infestations in Egyptian goats using oral dosing at 4.5 and 2.8 mg/kg. A 100% clearance of mature and immature Haemonchus contortus, Trichostrongylus axei, Ostertagia circumcincta, Coopera curticei, Bunostomum trigonocephalum and Chabertia ovina was obtained at the 4.5 mg/kg level. Very high levels of clearance against the mature worms were obtained at 2.8 mg/kg but the drug was less effective against immature worms at the lower dose rate. PCV, hemoglobin concentration and total erythrocyte counts declined after infection but became significantly (P less than 0.001) raised in treated animal.
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D004534:Egypt; D005260:Female; D006041:Goats / Q000097:blood / Q000469:parasitology*; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy / Q000662:veterinary*; D007978:Levamisole / Q000627:therapeutic use; D009349:Nematode Infections / Q000188:drug therapy / Q000453:epidemiology / Q000662:veterinary*
chemical_list: D000871:Anthelmintics; D001562:Benzimidazoles; D007978:Levamisole