Determinants of plasma uric acid.
Obesity, alcohol consumption, and hematocrit provide an index of plasma uric acid, which in path analysis has a cultural heritability of 0.11 in children and 0.23 in parents, a small maternal effect, and a genetic heritability of 0.25 in both generations. Preliminary evidence for a major locus is destroyed by the omission of one exceptional child. There is no evidence against the polygenic hypothesis for hyperuricemia in the Japanese-American population studied.
D000328:Adult; D000428:Alcohol Drinking; D005260:Female; D014644:Genetic Variation; D006400:Hematocrit; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000503:physiopathology; D010641:Phenotype; D012737:Sex Factors; D014527:Uric Acid / Q000097:blood*
D014527:Uric Acid