Effects of centrally applied thiamenidine on pressure response to central nervous system stimulation.
Rise in blood pressure and heart rhythm disorders were provoked in rabbits submitted to electrical stimulation of the central nervous system. When injected into the cisterna magna, the hypotensive agent thiamenidine at a single dose of 100 microgram caused a fall in blood pressure and heart rate; this was not the case when the same dose was applied intravenously. Thiamenidine did not hinder the pressor response following stimulation of subthalamic zones, yet a reduction of rhythm disorders was obtained when the drug was administered by either route. The results suggest a central nervous action of thiamenidine.
D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D002946:Cisterna Magna; D004558:Electric Stimulation; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D007031:Hypothalamus / Q000502:physiology*; D007093:Imidazoles / Q000494:pharmacology*; D007267:Injections; D008297:Male; D011817:Rabbits; D013876:Thiophenes / Q000494:pharmacology*
D000959:Antihypertensive Agents; D007093:Imidazoles; D013876:Thiophenes; C010354:tiamenidine