title: One model of outflow damage.
abstract: The intraocular pressure, facilities of outflow, and Po/C ratios of 3 groups of eyes were compared. Group 1 consisted of 20 eyes at risk to the development of acute closed-angle glaucoma that had been treated with prophylactic pilocarpine for at least 8 years. Group 2 consisted of 20 eyes at risk that had received no treatment and had been followed up for at least 4 years. Group 3 comprised 20 eyes in which there was no evidence of glaucoma. There were highly significant differences between the 3 groups. The 60 eyes were then provoked with pilocarpine and phenylephrine; 90% of Group 1, 75% of Group 2, and none of Group 3 developed significant gonioscopic angle closure. These results suggest that asymptomatic partial angle closure was the cause of the observed changes and provide a naturally occurring model of one mechanism that can produce outflow damage without clinical symptoms.
mesh_terms: D000867:Anterior Chamber / Q000187:drug effects / Q000502:physiology; D001082:Aqueous Humor / Q000502:physiology*; D005901:Glaucoma / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D010656:Phenylephrine; D010862:Pilocarpine / Q000627:therapeutic use; D012306:Risk
chemical_list: D010862:Pilocarpine; D010656:Phenylephrine