An aberrant nucleus in the telencephalon following administration of ENU during neuroembryogenesis.
Administration of ENU to rats during embryonic development caused the emergence of aberrant nuclei in the dorsal telencephalon. They were located in the corpus callosum, and were composed of pyramidal and stellate neurons. This suggested that the aberrant nuclei arose out of the neurons of cerebral cortex that had failed to migrate during embryogenesis. The aberrant nuclei were found predominantly in the animals receiving ENU on day 18 or earlier of gestation.
D000818:Animals; D002465:Cell Movement; D002540:Cerebral Cortex / Q000196:embryology; D003337:Corpus Callosum / Q000187:drug effects; D005038:Ethylnitrosourea / Q000633:toxicity*; D005260:Female; D005865:Gestational Age; D009474:Neurons / Q000187:drug effects; D009607:Nitrosourea Compounds / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D013687:Telencephalon / Q000187:drug effects* / Q000196:embryology / Q000648:ultrastructure
D009607:Nitrosourea Compounds; D005038:Ethylnitrosourea