The specificity of reactive synaptogenesis: a comparative study in the adult rat hippocampal formation.
The CA1 region of the hippocampus in the mature rat is shown to possess the capacity to form new synapses following a lesion of either the commissural afferents, which removes 41% of the synaptic input to stratum radiatum, or commissural and associational afferents, which destroys 74% of the synaptic input. With both types of lesion, extensive reinnervation occurs without obvious changes in lamination of afferent fibers and without accompanying changes in the acetylcholinesterase-(AChE) staining pattern. This is in contrast to what is known to occur in the hippocampal dentate gyrus following an ipsilateral entorhinal lesion where afferent lamination is reordered and where AChE-staining intensifies. A comparison between the disparate patterns of reinnervation in these closely related structures affords the opportunity to examine some of the specific factors that may regulate synaptic readjustments in brain.
D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D001345:Autoradiography; D001369:Axons / Q000648:ultrastructure; D003712:Dendrites / Q000648:ultrastructure; D003714:Denervation; D004292:Dominance, Cerebral / Q000502:physiology; D006624:Hippocampus / Q000033:anatomy & histology / Q000502:physiology*; D008297:Male; D009410:Nerve Degeneration; D009416:Nerve Regeneration; D009434:Neural Pathways / Q000033:anatomy & histology / Q000502:physiology; D009474:Neurons / Q000648:ultrastructure; D051381:Rats; D013569:Synapses / Q000502:physiology* / Q000648:ultrastructure
D000110:Acetylcholinesterase