title: Cold agglutinin autoimmune hemolytic anemia in nonhematologic malignancies.
abstract: Four patients with nonhematologic malignancies had the simultaneous finding of hemolytic anemia due to high-titer cold agglutinins. In each patient, the cold agglutinin had "anti-I" specificity and was of the IgM kappa immunoglobulin class. Although patients with hematologic malignancies not uncommonly have cold agglutinins, the association between these antibodies and nonhematologic malignancies is unusual.
mesh_terms: D000293:Adolescent; D000310:Adrenal Gland Neoplasms / Q000150:complications; D000368:Aged; D000373:Agglutinins; D000744:Anemia, Hemolytic, Autoimmune / Q000150:complications* / Q000276:immunology; D001323:Autoantibodies; D003080:Cold Temperature; D003110:Colonic Neoplasms / Q000150:complications; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications* / Q000276:immunology
chemical_list: D000373:Agglutinins; D001323:Autoantibodies