Ornithine decarboxylase activity and polyamine content of normal and fluoride resistant LS cells.
The activity of ornithine decarboxylase (ODC) in suspension cultures of mouse fibroblasts, LS cells, varied in a characteristic cyclic pattern after dilution of the cultures. Two strains of fluoride resistant LS cells, FR6 and LSFR6 cells, exhibited the same cyclic pattern, but with markedly higher ODC activities. These fluoride resistant cells, however, contained less putrescine, the product of the ODC reaction. Possible reasons for this finding are discussed.
D000818:Animals; D002262:Carboxy-Lyases / Q000378:metabolism*; D002460:Cell Line; D005347:Fibroblasts / Q000201:enzymology* / Q000378:metabolism; D005459:Fluorides / Q000494:pharmacology*; D051379:Mice; D009955:Ornithine Decarboxylase / Q000378:metabolism*; D011073:Polyamines / Q000378:metabolism*
D011073:Polyamines; D002262:Carboxy-Lyases; D009955:Ornithine Decarboxylase; D005459:Fluorides