Long-term cimetidine and anticholinergic therapy in patients with gastrinoma.
Two patients with gastrinomas were treated with cimetidine and an anticholinergic drug for greater than 20 months after exploratory laparotomy disclosed no solitary resectable tumor. Both have done well, and thus this therapy is recommended as a safe and effective alternative to total gastrectomy in reliable patients. Additional therapeutic methods are needed to control tumor growth.
D000284:Administration, Oral; D000328:Adult; D000863:Antacids / Q000009:adverse effects / Q000627:therapeutic use; D002927:Cimetidine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004341:Drug Evaluation; D005260:Female; D005750:Gastric Juice / Q000378:metabolism; D005755:Gastrins / Q000097:blood; D006146:Guanidines / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011413:Propantheline / Q000008:administration & dosage / Q000627:therapeutic use*; D012636:Secretory Rate / Q000187:drug effects; D013997:Time Factors; D015043:Zollinger-Ellison Syndrome / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery
D000863:Antacids; D005755:Gastrins; D006146:Guanidines; D011413:Propantheline; D002927:Cimetidine