Is the role of the environment in carcinogenesis overestimated?
The dominant role of the physical and chemical environment in the development of cancer is challenged. Analyses of the etiology of skin, bladder, respiratory and gastric cancers are presented which demonstrate the considerable extent to which one's health status may modify the initiation and promotion of environmentally associated cancers. It is concluded that although environmental factors may initiate and/or promote 85 to 90 percent of all cancers this is misleading since it neglects the critical role of the individual's health status as a factor modifying carcinogenesis.
D001205:Ascorbic Acid / Q000494:pharmacology; D001580:Benzopyrenes / Q000633:toxicity; D002274:Carcinogens, Environmental; D002283:Carcinoma, Bronchogenic / Q000139:chemically induced; D004032:Diet; D006801:Humans; D006838:Hydrocarbons / Q000633:toxicity; D009369:Neoplasms / Q000139:chemically induced / Q000209:etiology*; D009381:Neoplasms, Radiation-Induced; D044469:Racial Groups; D012256:Riboflavin / Q000494:pharmacology; D012878:Skin Neoplasms / Q000209:etiology / Q000235:genetics; D012907:Smoking / Q000150:complications; D013274:Stomach Neoplasms / Q000209:etiology / Q000517:prevention & control; D014466:Ultraviolet Rays / Q000009:adverse effects; D001749:Urinary Bladder Neoplasms / Q000209:etiology / Q000235:genetics; D014801:Vitamin A / Q000494:pharmacology
D001580:Benzopyrenes; D002274:Carcinogens, Environmental; D006838:Hydrocarbons; D014801:Vitamin A; D001205:Ascorbic Acid; D012256:Riboflavin