Regulatory interrelations between GABA and polyamines. I. Brain GABA levels and polyamine metabolism.
Elevation of brain GABA levels by GABA-T inhibition is accompanied by a decrease of S-adenosylmethionine decarboxylase activity. This is followed by an increase of ornithine decarboxylase activity and a severalfold increase of brain putrescine levels. Spermidine and spermine levels are not significantly affected under these conditions. These unexpected findings support a regulatory interaction between GABA and polyamine metabolism.
D000612:4-Aminobutyrate Transaminase / Q000037:antagonists & inhibitors; D012437:Adenosylmethionine Decarboxylase / Q000037:antagonists & inhibitors; D000614:Aminocaproates / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000378:metabolism*; D008297:Male; D051379:Mice; D065108:Ornithine Decarboxylase Inhibitors; D011073:Polyamines / Q000378:metabolism*; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D000614:Aminocaproates; D065108:Ornithine Decarboxylase Inhibitors; D011073:Polyamines; D005680:gamma-Aminobutyric Acid; D000612:4-Aminobutyrate Transaminase; D012437:Adenosylmethionine Decarboxylase