title: [Acetlysalicylic acid, protective antacid effect and lesions of the gastric mucosa. Effect of acetylsalicylic acid and an antacid drug (Gastropulgit Tabs) on the transmural electric potential in the human stomach].
abstract: Antacids are able to prevent acetylsalicylic acid-induced functional and morphological changes of the gastric mucosa. In order to test whether a new antacid in chewing-tablet form (Gastropulgit Tabs) might be able to protect the gastric mucosa from acetylsalicylic acid-induced functional changes similarly to liquid antacids the effect of this antacid on acetylsalicylic acid-induced changes of transmural gastric potential difference was measured in healthy volunteers. The decrease of transmural potential differences induced by 640 mg acetylsalicylic acid could be prevented by simultaneous addition of 2 tablets of Gastropulgit Tabs. Thus the antacid in tablet form is able-like liquid antacids-to protect the gastric mucosa against acetylsalicylic acid-induced functional changes.
mesh_terms: D000534:Alum Compounds / Q000627:therapeutic use; D000863:Antacids / Q000627:therapeutic use*; D001241:Aspirin / Q000009:adverse effects*; D004341:Drug Evaluation; D005753:Gastric Mucosa / Q000187:drug effects; D006801:Humans; D008274:Magnesium / Q000627:therapeutic use; D008564:Membrane Potentials / Q000187:drug effects*
chemical_list: D000534:Alum Compounds; D000863:Antacids; D008274:Magnesium; D001241:Aspirin
vernacular_title: Azetylsalizylsäure, protektive Antazida-Wirkung und Schädigung der Magenschleimhaut. Beeinflussung der transmuralen elektrischen Potentialdifferenz des menschlichen Magens durch Azetylsalizylsäure und eine Antazida-Präparation (Gastropulgit Tabs).