Additional induction of microsomal cytochrome(s) P 450 in mouse liver by consecutive application of cadmium chloride and phenobarbital.
Mice were treated intraperitoneally over 20 days with 0,30; 0,10 and 0,03 mg Cd+2/kg.day. Subsequent induction of microsomal metabolism by 50 mg phenobarbital/kg.day over 5 days revealed increased microsomal cytochrome P 450 content in Cd+2-pretreated animals as compared to animals treated only with phenobarbital. The microsomal cadmium content of animals having received cadmium plus phenobarbital was about 5 times higher than that of animals treated with cadmium alone. The only enzyme activity found to be changed by cadmium in induced microsomes was ethylmorphine-N-deethylation. In phenobarbital-free animals no microsomal changes by cadmium could be detected.
D000818:Animals; D001579:Benzopyrene Hydroxylase / Q000378:metabolism; D001713:Biphenyl Compounds / Q000378:metabolism; D002104:Cadmium / Q000378:metabolism / Q000494:pharmacology*; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis*; D004347:Drug Interactions; D004790:Enzyme Induction / Q000187:drug effects; D006591:Hexobarbital / Q000494:pharmacology; D006993:Hypnotics and Sedatives; D008297:Male; D008780:Methyltransferases / Q000378:metabolism; D051379:Mice; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D010634:Phenobarbital / Q000494:pharmacology*; D011506:Proteins / Q000378:metabolism
D001713:Biphenyl Compounds; D006993:Hypnotics and Sedatives; D011506:Proteins; D002104:Cadmium; D003577:Cytochrome P-450 Enzyme System; D006591:Hexobarbital; D001579:Benzopyrene Hydroxylase; D008780:Methyltransferases; D010634:Phenobarbital