title: Action of staphylococcal alpha-toxin on membranes: some recent advances.
abstract: Recent developments in the area of Staphylococcal alpha-toxin studies are presented which modify the concepts previously held with respect to both biological and physical properties of alpha-toxin. New data concerning the nature of the binding site for alpha-toxin on rabbit erythrocyte membranes and a model to explain the various observed complexes of alpha-toxin and membrane receptor are discussed. Finally, evidence suggesting that Staphylococcal alpha-toxin is a potent demyelinating agent is presented.
mesh_terms: D000818:Animals; D001427:Bacterial Toxins / Q000378:metabolism / Q000494:pharmacology*; D001665:Binding Sites; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000378:metabolism; D004912:Erythrocytes / Q000187:drug effects*; D006460:Hemolysin Proteins; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D007457:Iodine Radioisotopes; D051379:Mice; D008954:Models, Biological; D009186:Myelin Sheath / Q000187:drug effects; D009498:Neurotoxins / Q000494:pharmacology; D011817:Rabbits; D013210:Staphylococcus
chemical_list: D001427:Bacterial Toxins; D006460:Hemolysin Proteins; D007457:Iodine Radioisotopes; D009498:Neurotoxins; C021091:staphylococcal alpha-toxin