[Antitumor and immunodepressive action of dexamethasone on a leukemia L-1210 model].
The effect of single administration of dexamethason in doses of 10, 20, 50 and 100 mg/kg on the spleen content of lymphomic colonies, normal colony-forming units and antibody-forming cells was studied in experiments on CBA and DBA/2 mice with transplanted leukemia L-1210. It has bear dependence on the dosage, the immunodepressant action of the drug being more pronounced in CBA mice as compared to DBA/2 mice with leukemia L-1210. The immunodepressant activity of dexamethason is approximately equal to the antineoplasic one. Single administration of the drug has practically no effect on hemopoiesis.
D000818:Animals; D000937:Antigen-Antibody Reactions / Q000187:drug effects; D000970:Antineoplastic Agents; D003114:Colony-Forming Units Assay; D003907:Dexamethasone / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004306:Dose-Response Relationship, Immunologic; D004353:Drug Evaluation, Preclinical; D006410:Hematopoiesis / Q000187:drug effects; D007166:Immunosuppressive Agents; D007939:Leukemia L1210 / Q000188:drug therapy*; D051379:Mice; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D009368:Neoplasm Transplantation; D013997:Time Factors
D000970:Antineoplastic Agents; D007166:Immunosuppressive Agents; D003907:Dexamethasone
Protivoopukholevoe i immunodepressivnoe deĭstvie deksamteazona na modeli leĭoza L-1210.