A histochemical technique for evaluation of progesterone receptors in breast cancer.
A histochemical method for the detection and localization of progesterone receptors in human breast cancer has been developed employing a fluorescein labeled conjugate of bovine serum albumin linked to a progestin as the binding hormone. Considerable tumor cell receptor heterogeneity was apparent and nuclear binding was frequently noted. The results of the new assay correlated with those obtained by dextran-coated charcoal assay in 91 per cent of specimens.
D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D008722:Methods; D011980:Receptors, Progesterone / Q000032:analysis*
D011980:Receptors, Progesterone