Rubber solvent: a clastogenic agent that fails to induce sister-chromatid exchanges.
Rubber solvent was tested for its ability to induce chromosome aberrations and sister-chromatid exchanges in human whole blood cultures. Following exposure to relatively low rubber solvent concentrations (0.0125% and greater) significant increases in the frequencies of chromatid gaps and breaks were observed. At higher rubber-solvent concentrations (0.05% and greater) there were also significant increases in the frequency of chromosome breaks. In contrast to the increase in chromosome aberrations following rubber-solvent exposure, rubber-solvent concentrations up to the toxic level failed to produce increases in the sister-chromatid exchange frequency.
D002478:Cells, Cultured; D002842:Chromatids / Q000187:drug effects*; D002869:Chromosome Aberrations; D002877:Chromosomes, Human / Q000187:drug effects*; D003434:Crossing Over, Genetic; D004353:Drug Evaluation, Preclinical; D006801:Humans; D006838:Hydrocarbons / Q000494:pharmacology*; D008214:Lymphocytes / Q000648:ultrastructure; D009153:Mutagens; D010578:Petroleum; D012408:Rubber; D012997:Solvents / Q000494:pharmacology*
D006838:Hydrocarbons; D009153:Mutagens; D010578:Petroleum; D012997:Solvents; C021084:rubber solvent; D012408:Rubber