Hydrolysis of 11-palmitoyloxy-delta 9-tetrahydrocannabinol to 11-hydroxy-delta 9-tetrahydrocannabinol by cholesterol esterase and a lipase.
11-Palmitoyloxy-delta 9-tetrahydrocannabinol (11-palm-delta 9-THC) has been identified in the rat in our laboratory as a long-retained metabolite of delta 9-tetrahydrocannabinol (delta 9-THC), the active component of marihuana (Leighty, 1973). Although it is not known as yet if 11-palm-delta 9-THC is itself psychoactive it could be hydrolyzed to active 11-hydroxy-delta 9-tetrahydrocannabinol (11-OH-delta 9-THC). Our in vitro studies show that cholesterol esterase and a lipase can hydrolyze 11-palm-delta 9-THC to 11-OH-delta 9-THC.
D000818:Animals; D002265:Carboxylic Ester Hydrolases / Q000378:metabolism*; D013759:Dronabinol / Q000031:analogs & derivatives* / Q000378:metabolism; D006868:Hydrolysis; D008049:Lipase / Q000378:metabolism*; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D051381:Rats; D002787:Sterol Esterase / Q000378:metabolism*; D013997:Time Factors
D013759:Dronabinol; D002265:Carboxylic Ester Hydrolases; D002787:Sterol Esterase; D008049:Lipase