Inhibition of DNA synthesis by nitroheterocycles. I. Correlation with half-wave reduction potential.
Twenty-one nitroheterocycles, including metronidazole, misonidazole and AF-2, were tested for their ability to inhibit DNA synthesis in mouse L-929 cells growing in culture. All those tested inhibited the rate of incorporation of 3H-thymidine into L cells following drug treatment for 4 h under aerobic conditions. Only 4 drugs reached their limits of solubility before the uptake of 3H-thymidine was inhibited by 50% or more. For the remaining 17, the log of the concentration producing 50% inhibition of incorporation was directly correlated with the half-wave reduction potential of the compound.
D000818:Animals; D004247:DNA / Q000096:biosynthesis*; D003864:Depression, Chemical; D005668:Furylfuramide / Q000494:pharmacology; D007739:L Cells / Q000378:metabolism; D008795:Metronidazole / Q000494:pharmacology; D051379:Mice; D008920:Misonidazole / Q000494:pharmacology; D009581:Nitrofurans / Q000494:pharmacology*; D009593:Nitroimidazoles / Q000494:pharmacology*; D009600:Nitroquinolines / Q000494:pharmacology; D010084:Oxidation-Reduction; D013936:Thymidine / Q000378:metabolism
D009581:Nitrofurans; D009593:Nitroimidazoles; D009600:Nitroquinolines; D005668:Furylfuramide; D008795:Metronidazole; D008920:Misonidazole; D004247:DNA; D013936:Thymidine