title: Anticonvulsant, analgesic and monoamine oxidase inhibitory properties of newer 4-hydroxy-4-phenylpiperidinocarbamides.
abstract: Fourteen 1-[N-acetyl(4-hydroxy-4-phenyl-piperidino)]-3-aryl carbamides were synthesized, characterized and evaluated for their anticonvulsant, analgesic and monoamine oxidase inhibitory properties. All carbamides (100 mg/kg, i.p.) provided 20--60% protection against pentylenetetrazol-induced seizures in mice. The analgesic activity possessed by these carbamides, with the exception of two compounds, was reflected by their ability to provide 17--67% protection against tail pinch response in mice. All carbamides (1 mM) inhibited (5--90%) in vitro activity of rat brain monoamine oxidase. The low toxicity of these carbamides was reflected by their higher approximate LD50 values which ranged from 500 - greater than 1000 mg/kg.
mesh_terms: D000700:Analgesics; D000818:Animals; D000927:Anticonvulsants; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008996:Monoamine Oxidase Inhibitors; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D010880:Piperidines / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats
chemical_list: D000700:Analgesics; D000927:Anticonvulsants; D008996:Monoamine Oxidase Inhibitors; D010880:Piperidines; D010433:Pentylenetetrazole