Conservation of ribosomal fidelity during ageing.
The function of ribosomes prepared from the liver of young (2--5 months old) and senescent (15--26 months old) mice were compared in vitro. The conclusions that can be drawn from the liver of senescent mice is 10 to 40% lower than that of young mice; (2) the fidelity of translation does not change grossly with age; (3) the thermosensitivity of translational activity of ribosomes and the activity of ribosome-associated ribonuclease do not change with age; (4) there is an age-dependent accumulation of free 40S ribosomal subunits in the cytoplasm of mouse liver. The relation of age-dependent changes in the structure and function of ribosomes is discussed.
D000375:Aging; D000818:Animals; D008099:Liver / Q000254:growth & development* / Q000378:metabolism; D008297:Male; D051379:Mice; D010452:Peptide Biosynthesis; D011072:Poly U; D011132:Polyribosomes / Q000378:metabolism; D014176:Protein Biosynthesis; D012343:RNA, Transfer / Q000378:metabolism; D012270:Ribosomes / Q000378:metabolism* / Q000648:ultrastructure
D011072:Poly U; D012343:RNA, Transfer