title: Evaluation of 133Xe clearance curves in the study of lingual blood flow in dogs.
abstract: Lingual blood flow was studied in dogs by the 133Xe clearance technique under control conditions, during epinephrine infusion in response to the combined treatment with Regitin and epinephrine. The composite washout curves recorded during control conditions could be resolved into three monoesponential components. It is suggested that the steep initial slope (component I)is caused by the fraction of blood that perfuses the A-V anastomoses of the tongue. Component II and III appear to the effect of epinephrine infusion might indicate the closure of arterio-venous anastomoses containing alpha receptors. Regitin pretreatment could prevent the closure of the arterio-venous anastomoses elicited by epinephrine infusion. The beta receptor stimulating activity of epinephrine migh account for the augmentation of blood flow to lingual musculature.
mesh_terms: D000818:Animals; D004285:Dogs; D004837:Epinephrine / Q000494:pharmacology*; D005260:Female; D008297:Male; D010477:Perfusion; D010646:Phentolamine / Q000494:pharmacology; D014059:Tongue / Q000098:blood supply*; D014980:Xenon Radioisotopes
chemical_list: D014980:Xenon Radioisotopes; D004837:Epinephrine; D010646:Phentolamine