Alteration in cell division, morphology and motility induced by the toxic principle of lupinosis.
A number of experiments are described in which the effect of the toxins causing lupinosis on cell morphology and motility is examined. The toxins arrested cells in metaphase leading to abnormal profiles, and inhibited leucocyte migration. Similar results were obtained with colchicine on cell division and, from the evidence obtained, it is suggested that the mechanism of action of the two agents is similar and that the same binding sites are probably involved.
D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D002465:Cell Movement / Q000187:drug effects*; D002478:Cells, Cultured / Q000187:drug effects* / Q000648:ultrastructure; D003078:Colchicine / Q000494:pharmacology; D006801:Humans; D008107:Liver Diseases / Q000503:physiopathology*; D008677:Metaphase / Q000187:drug effects; D008938:Mitosis / Q000187:drug effects; D009181:Mycoses / Q000503:physiopathology*; D014118:Toxins, Biological / Q000009:adverse effects*
D014118:Toxins, Biological; D003078:Colchicine