title: Mutagenic specificity in reovirus.
abstract: Mutagenic specificity in response to chemical mutagens has been observed with certain temperature-sensitive mutants of reovirus type 3. One mutant induced by nitrous acid reverted specifically with nitrous acid. Three nitrosoguanidine-induced mutants reverted after nitrous acid treatment. These findings thus suggest that analysis of chemical induction of reversion from the temperature-sensitive phenotype may be a useful approach for studying the nature of mutation in animal viruses.
mesh_terms: D012089:Mammalian orthoreovirus 3 / Q000187:drug effects* / Q000235:genetics; D009153:Mutagens; D009154:Mutation; D009573:Nitrites / Q000494:pharmacology*; D009604:Nitrosoguanidines / Q000494:pharmacology*; D009608:Nitrous Acid / Q000494:pharmacology*; D010641:Phenotype; D012087:Reoviridae / Q000187:drug effects*; D013696:Temperature
chemical_list: D009153:Mutagens; D009573:Nitrites; D009604:Nitrosoguanidines; D009608:Nitrous Acid