title: Pathophysiologic response of the juxtaglomerular apparatus to dietary sodium restriction in the dog.
abstract: Pathophysiologic changes in the juxtaglomerular apparatus (JGA) of the dog were induced by 10 days of dietary sodium restriction (less than 1 mEq of Na+/day). Plasma renin activity increased 12-fold and plasma aldosterone values increased 60-fold, whereas urinary sodium excretion decreased precipitously. Urinary potassium excretion remained within normal values throughout the period of sodium restriction. The JGA cell counts, determined by light microscopy, were significantly (P = less than 0.05) increased after 2 days of sodium restriction and remained increased through day 10. Adrenal gland weights and the cross-sectional width of the zona glomerulosa were not altered. Ultrastructurally, JGA cells showed progressive hypertrophy and hyperplasia. The Golgi apparatus became more prominent. The endoplasmic reticulum increased, as did the number of ribosomes. Cytoplasmic secretory granules increased in number and size from day 2 through day 6. On days 8 and 10, fewer and smaller secretory granules were encountered, even though plasma renin and aldosterone values continued to increase. In the dog maintained in a balanced sodium state, little renin is stored in cytoplasmic granules of the juxtaglomerular cells. Short-term stimulation results in increased plasma renin values and increased production and storage of renin in JGA cells. Continued stimulation results in depletion of cytoplasmic stores, although plasma renin content continues to rise, suggesting that renin is produced and secreted directly during more prolonged stimulation.
mesh_terms: D000450:Aldosterone / Q000097:blood; D000818:Animals; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D004039:Diet, Sodium-Restricted / Q000662:veterinary*; D004285:Dogs / Q000033:anatomy & histology / Q000378:metabolism*; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D005260:Female; D007606:Juxtaglomerular Apparatus / Q000648:ultrastructure*; D008297:Male; D011188:Potassium / Q000652:urine; D012083:Renin / Q000097:blood; D012964:Sodium / Q000652:urine
chemical_list: D000450:Aldosterone; D012964:Sodium; D012083:Renin; D011188:Potassium