Suppression of the inductive effects of phenobarbital and 3-methylcholanthrene on ascorbic acid synthesis and hepatic cytochrome P-450-linked monooxygenase systems by the interferon inducers, poly rI.rC and tilorone.
D000818:Animals; D001205:Ascorbic Acid / Q000096:biosynthesis* / Q000652:urine; D001579:Benzopyrene Hydroxylase / Q000096:biosynthesis; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004790:Enzyme Induction / Q000187:drug effects; D005037:Ethylmorphine-N-Demethylase / Q000096:biosynthesis; D005449:Fluorenes / Q000494:pharmacology*; D008297:Male; D008748:Methylcholanthrene / Q000494:pharmacology*; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D010105:Oxygenases / Q000378:metabolism*; D010634:Phenobarbital / Q000494:pharmacology*; D011070:Poly I-C / Q000494:pharmacology*; D051381:Rats; D013994:Tilorone / Q000494:pharmacology*
D005449:Fluorenes; D008748:Methylcholanthrene; D003577:Cytochrome P-450 Enzyme System; D010105:Oxygenases; D001579:Benzopyrene Hydroxylase; D005037:Ethylmorphine-N-Demethylase; D013994:Tilorone; D011070:Poly I-C; D001205:Ascorbic Acid; D010634:Phenobarbital