title: Teratogenic and carcinogenic effects of some chemicals during perinatal life in rats, Syrian golden hamsters, and minipigs.
abstract: Teratogenic effects of ENU have been observed in the rat, Syrian golden hamster, and minipig. In BD and Wistar rats, as well as in hamsters, ENU is a potent carcinogen when administered prenatally. Other members of the homologous series of alkylnitrosoureas, except n-propylnitrosourea, have been shown to be less active or totally inactive as carcinogens in experiments on prenatal animals. Simultaneous oral administration of L-citrulline and sodium nitrite induced adenosarcomas of the kidney (Wilm's tumors) in 6 of 22 offspring. The importance of prophylactic measures in man during prenatal development is emphasized.
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000139:chemically induced; D002273:Carcinogens; D006224:Cricetinae; D005038:Ethylnitrosourea / Q000633:toxicity; D005260:Female; D008431:Maternal-Fetal Exchange; D008647:Mesocricetus; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology; D009607:Nitrosourea Compounds / Q000378:metabolism / Q000633:toxicity*; D010524:Peripheral Nervous System Neoplasms / Q000139:chemically induced; D011247:Pregnancy; D051381:Rats; D013120:Spinal Cord Neoplasms / Q000139:chemically induced; D013552:Swine; D013723:Teratogens
chemical_list: D002273:Carcinogens; D009607:Nitrosourea Compounds; D013723:Teratogens; D005038:Ethylnitrosourea