Effect of alloxan diabetes on some aspects of lipid metabolism in albino rats.
Administration of alloxan (40 mg/kg i.v.) caused a marked decrease in the lipolytic and esterolytic activities of rat aorta. This effect was completely reversed when the diabetic rats were treated with low doses of insulin (2-3 U/die) for 3 days. The insulin-dependence of esterolysis and lipolysis in rat aorta and the role of hydrolases in atherogenesis in experimental diabetes have been discussed.
D000496:Alloxan / Q000494:pharmacology; D000818:Animals; D001012:Aorta, Abdominal / Q000378:metabolism; D001013:Aorta, Thoracic / Q000378:metabolism; D001786:Blood Glucose / Q000032:analysis; D002265:Carboxylic Ester Hydrolases / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D007328:Insulin / Q000494:pharmacology; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism*; D051381:Rats
D001786:Blood Glucose; D007328:Insulin; D000496:Alloxan; D002265:Carboxylic Ester Hydrolases