Inhibition of the action of anticonvulsants by lithium treatment.
The present study demonstrates that the effectiveness of anticonvulsants significantly decreases following lithium treatment (3 doses of 50 mg/kg of LiCl given every 12 hr). The anticonvulsant action of phenytoin, phenobarbital and of 3 carbonic anhydrase inhibitors: methazolamide, acetazolamide, ethoxzolamide, was assessed in rats subjected to maximal electroshock. In a chronic study on tolerance development to the anticonvulsant action of acetazolamide, lithium treatment (10 mg/kg per day) has been shown to inhibit gradually the action of acetazolamide. These results are consistent with the hypothesis that norepinephrine and dopamine are involved in the action of anticonvulsants.
D000818:Animals; D000927:Anticonvulsants / Q000037:antagonists & inhibitors*; D001923:Brain Chemistry / Q000187:drug effects; D004361:Drug Tolerance; D004597:Electroshock; D008094:Lithium / Q000378:metabolism / Q000494:pharmacology*; D008297:Male; D011188:Potassium / Q000378:metabolism; D051381:Rats; D012964:Sodium / Q000378:metabolism; D013997:Time Factors
D000927:Anticonvulsants; D008094:Lithium; D012964:Sodium; D011188:Potassium