Interaction of zinc and other metal on the activity of erythrocyte delta-aminolevulinic acid dehydratase in vitro.
The interaction of zinc and other metal such as lead, mercury (II), cadmium, silver (II) on the activity of erythrocyte delta-aminolevulinic acid dehydratase (ALA-D) was investigated in vitro. At the concentrations ranging from 0.01 to 1.0 mmol/l, lead, mercury (II), cadmium and silver (II) strikingly inhibited the erythrocyte ALA-D activity. The in vitro addition of zinc having an activating effect for the erythrocyte ALA-D, was observed to eliminate the lead-induced inhibition of the erythrocyte ALA-D activity. And the degree of the elimination seemed to depend on the molar ratio (Zn/Pb) of both metal concentrations in the ALA-D assay. However, the inhibition of erythrocyte ALA-D activity caused by mercury (II), cadmium and silver (II) was not removed by the in vitro addition of zinc.
D002104:Cadmium / Q000494:pharmacology; D004347:Drug Interactions; D004912:Erythrocytes / Q000201:enzymology*; D006801:Humans; D066298:In Vitro Techniques; D007854:Lead / Q000494:pharmacology; D008628:Mercury / Q000494:pharmacology; D008670:Metals / Q000494:pharmacology*; D000623:Porphobilinogen Synthase / Q000097:blood*; D012834:Silver / Q000494:pharmacology; D015032:Zinc / Q000494:pharmacology*
D008670:Metals; D002104:Cadmium; D007854:Lead; D012834:Silver; D000623:Porphobilinogen Synthase; D008628:Mercury; D015032:Zinc