title: Imbalance in X-chromosome expression: evidence for a human X-linked gene affecting growth of hemopoietic cells.
abstract: In each of six family members who were heterozygous at the X-linked locus for glucose-6-phosphate dehydrogenase, only one or the other of the two alleles at that locus was almost exclusively expressed. The data are consistent with evidence that X-chromosome inactivation is a random process that may be followed by selection for one of the two resulting cell types on the basis of an unknown gene, which is located on the X chromosome and which can affect the rate of proliferation of hemopoietic cells in humans.
mesh_terms: D000483:Alleles; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D008040:Genetic Linkage; D005954:Glucosephosphate Dehydrogenase / Q000097:blood / Q000235:genetics; D006410:Hematopoiesis; D006579:Heterozygote; D006801:Humans; D007962:Leukocytes / Q000201:enzymology; D009030:Mosaicism; D012730:Sex Chromosomes; D014960:X Chromosome
chemical_list: D005954:Glucosephosphate Dehydrogenase