Lipid packing and transbilayer asymmetries of mixed lipid vesicles.
Predictions, based on a previously developed theory, of the radii and asymmetric lipid distribution of mixed phosphatidylcholine/lysophosphatidylcholine and phosphatidylcholine/cholesterol vesicles of variable composition are presented. The results compare well with available experimental data, except for cis-unsaturated phosphatidylcholine/cholesterol vesicles at high concentrations of cholesterol. It is concluded that specific lipid-lipid interactions need not be invoked for saturated and trans-unsaturated phosphatidylcholine mixed with lysophosphatidylcholine or cholesterol. A discussion of the effect of packing stresses on induced flip-flop and non-spherical vesicles is also presented.
D002784:Cholesterol; D008051:Lipid Bilayers; D008244:Lysophosphatidylcholines; D008433:Mathematics; D008823:Micelles; D008968:Molecular Conformation; D010713:Phosphatidylcholines; D013329:Structure-Activity Relationship
D008051:Lipid Bilayers; D008244:Lysophosphatidylcholines; D008823:Micelles; D010713:Phosphatidylcholines; D002784:Cholesterol