Effect of monofluoroacetate on renal H+ excretion in the rat.
In order to investigate the effect of monofluoroacetate (MFA) on renal H+ excretion, anesthetized rats under mannitol diuresis were given intraperitoneally MFA and some of the acido-basic status parameters were determined. Urinary pH and pCO2 did not change after MFA administration, while urinary flow rate increased. MFA induced a decrease in H+ net excretion and in ammonia excretion. Titratable acidity did not change significantly within the experiment.
D000136:Acid-Base Equilibrium / Q000187:drug effects; D000143:Acids / Q000652:urine*; D000641:Ammonia / Q000652:urine; D000818:Animals; D002245:Carbon Dioxide / Q000652:urine; D004231:Diuresis / Q000187:drug effects; D005463:Fluoroacetates / Q000494:pharmacology*; D008297:Male; D008353:Mannitol / Q000494:pharmacology; D051381:Rats
D000143:Acids; D005463:Fluoroacetates; D002245:Carbon Dioxide; D008353:Mannitol; D000641:Ammonia