Investigation of a case of prednisolone malabsorption.
Malabsorption of prednisolone administered as enteric coated tablets was suspected following therapeutic failure in an asthmatic. This was investigated by cortisol estimation and a Synacthen test and substantiated by the demonstration of abnormally low absorption of prednisolone from these tablets which nevertheless were normally absorbed by a volunteer. The absorption of prednisolone from conventional tablets in this patient was normal.
D001249:Asthma / Q000188:drug therapy; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D008875:Middle Aged; D011239:Prednisolone / Q000008:administration & dosage / Q000378:metabolism* / Q000627:therapeutic use; D013608:Tablets, Enteric-Coated
D013608:Tablets, Enteric-Coated; D011239:Prednisolone