[Retinopathy due to amino-4-quinoleines group of the synthetic antimalarial drugs (author's transl)].
The use of overdoses of amino-4-quinoleines in non-malarial diseases has demonstrated various toxic actions on eyes. The most severe is retina lesion. Metabolism of these drugs and pathogeny of the lesions are discussed. With regard to aetiology, the main factor is overdose and duration of treatment. Clinical aspects are classified in three phases; the third one is divided in 5 stages. Treatment is only prophylactic.
D000328:Adult; D000634:Aminoquinolines / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D004305:Dose-Response Relationship, Drug; D006801:Humans; D010857:Pigment Epithelium of Eye / Q000187:drug effects; D012160:Retina / Q000187:drug effects; D012164:Retinal Diseases / Q000139:chemically induced* / Q000175:diagnosis
D000634:Aminoquinolines
La rétinopathie par les antipaludéens de synthèse du groupe des amino 4 quinoléines.