Bromelian, a thiolprotease from pineapple stem, depletes high molecular weight kininogen by activation of Hageman factor (Factor XIII).
D000818:Animals; D001963:Bromelains / Q000008:administration & dosage / Q000494:pharmacology*; D005174:Factor XII / Q000378:metabolism*; D006801:Humans; D007275:Injections, Intravenous; D007704:Kininogens / Q000378:metabolism*; D007705:Kinins / Q000096:biosynthesis; D008970:Molecular Weight; D010447:Peptide Hydrolases / Q000494:pharmacology; D011288:Prekallikrein / Q000096:biosynthesis; D051381:Rats; D013438:Sulfhydryl Compounds / Q000494:pharmacology
D007704:Kininogens; D007705:Kinins; D013438:Sulfhydryl Compounds; D001963:Bromelains; D005174:Factor XII; D011288:Prekallikrein; D010447:Peptide Hydrolases