On the molecular-weight-dependence of the anticoagulant activity of heparin.
The inactivation of thrombin and factor Xa by antithrombin was determined in the presence of heparin fractions of different molecular weights and with high affinity for antithrombin. The ability to potentiate the inactivation of either coagulation factor increased with increasing length of the polysaccharide chain.
D000990:Antithrombin III; D005170:Factor X / Q000037:antagonists & inhibitors*; D006493:Heparin; D008970:Molecular Weight; D011485:Protein Binding; D013917:Thrombin / Q000037:antagonists & inhibitors*
D000990:Antithrombin III; D005170:Factor X; D006493:Heparin; D013917:Thrombin