Hageman factor activation and tight junction disruption in mice challenged with attenuated endotoxin.
Endotoxin treated with chromium chloride is less toxic to mice than the parent molecule, but can disrupt intestinal permeability barriers and has an enhanced ability to activate Hageman factor.
D000818:Animals; D002857:Chromium / Q000494:pharmacology*; D004731:Endotoxins / Q000037:antagonists & inhibitors* / Q000633:toxicity; D004848:Epithelium / Q000648:ultrastructure; D005174:Factor XII / Q000378:metabolism*; D007082:Ileum / Q000187:drug effects* / Q000648:ultrastructure; D007365:Intercellular Junctions / Q000187:drug effects*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D051379:Mice; D010539:Permeability; D012485:Salmonella typhi
D004731:Endotoxins; D008070:Lipopolysaccharides; D002857:Chromium; D005174:Factor XII