title: Spindle-shaped appendages of IIIab-pyramids filled with lipofuscin: a striking pathological change of the senescent human isocortex.
abstract: Brains from 30 mentally normal men, ranging in age from 18--90 years, were studied to assess the occurrence and development of lipofuscin-filled spindle-shaped appendages of pyramidal cells of the isocortex; these can generally be encountered in the senescent brain within layer IIIab. The number of pigmented spindles was determined in a circumscribed part of prefrontal area revealing a close association of this conspicuous pathological alteration with growing age.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging; D001344:Autopsy; D002540:Cerebral Cortex / Q000166:cytology* / Q000473:pathology; D006801:Humans; D008062:Lipofuscin / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009474:Neurons / Q000032:analysis*; D010860:Pigments, Biological / Q000032:analysis*
chemical_list: D008062:Lipofuscin; D010860:Pigments, Biological