Induction of lethal mutations in female mice by 9 generations of gamma-irradiation during foetal development.
Female CBA mice were chronically gamma-irradiated in utero during either of two periods, the 10th to 14th days or the 14th to 18th days of gestation. The doses administered were 34 rad/generation in the earlier group and 160 rad/generation in the latter with dose rates of 0.3 rad/h and 1.7 rad/h, respectively. The doses were given through 9 generations. The effect of the irradiation was expressed as an increased frequency in the rate of recessive lethal equivalents by just above 4%. This corresponds to a mutation rate of 1.5 X 10(-4) mutation/rad/genome in the animals irradiated during the 10th to 14th gestational days and 0.3 X 10(-4) mutation/rad/genome in the 14th to 18th day group. As in earlier investigations, neither dominant mutations nor dominance effects of induced recessive lethal equivalents were found.
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005333:Fetus / Q000528:radiation effects*; D005720:Gamma Rays; D005804:Genes, Lethal; D005808:Genes, Recessive; D051379:Mice; D008808:Mice, Inbred CBA / Q000235:genetics; D009154:Mutation; D010053:Ovary / Q000528:radiation effects*; D013997:Time Factors