[Influence of the stratum corneum on transepidermal water loss and Bioavailability of a new topical steroid, difluprednate: clinical implications (author's transl)].
Comparative study of experimental and theoretical curves obtained by plotting transepidermal water loss against stratum corneum thickness in man, shows that every layer in the stratum corneum acts as part of the epidermal barrier to water loss. Another function of the stratum corneum is to decrease the cutaneous penetration of topical corticosteroids like difluprednate and to modify their bioavailability ('corticosteroid reservoir'). Our data suggest that variations in stratum corneum thickness between subjects explain variation of transepidermal water loss and sensitivity difluprednate, as there is a close relationship between these two parameters. It is then conceivable than the phototype has clinical implications is there really exists a relationship between phototype, stratum corneum thickness and sensitivity to steroids.
D000287:Administration, Topical; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000494:pharmacology; D001682:Biological Availability; D000078404:Epidermal Cells; D004817:Epidermis / Q000098:blood supply / Q000502:physiology*; D005477:Fluprednisolone / Q000031:analogs & derivatives* / Q000378:metabolism; D006801:Humans; D013045:Species Specificity; D014661:Vasoconstriction / Q000187:drug effects*; D014870:Water Loss, Insensible
D000305:Adrenal Cortex Hormones; D005477:Fluprednisolone
Influence du stratum corneum sur la perspiration insensible et sur la biodisponibilité d'un nouveau stéroïde topique, le difluprednate. Implications thérapeutiques.