Renal excretion mechanism of a nonionic contrast agent.
The renal excretion mechanism of a nonionic experimental contrast agent, C-29, was investigated in rabbits in comparison with the ionic contrast agent sodium diatrizoate under conditions of free urine flow and ureteral stasis. The two contrast agents were injected as a mixture of 125I-C-29 and 131I-sodium diatrizoate, in doses of 25 and 250 mg I/kg. The results indicate that, during the period relevant for urographic examinations, C-29 may have a renal clearance as low as 0.7 times that of sodium diatrizoate under conditions of both free urine flow and ureteral stasis. The biologic half-life of C-29 is 41-50 min.
D000818:Animals; D001769:Blood; D003287:Contrast Media / Q000008:administration & dosage / Q000378:metabolism*; D003973:Diatrizoate / Q000008:administration & dosage / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005260:Female; D007275:Injections, Intravenous; D007457:Iodine Radioisotopes; D007477:Ions; D007483:Iothalamic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D007668:Kidney / Q000378:metabolism*; D008297:Male; D011817:Rabbits; D014556:Urine / Q000032:analysis
D003287:Contrast Media; D007457:Iodine Radioisotopes; D007477:Ions; D003973:Diatrizoate; D007483:Iothalamic Acid