title: [Mexiletine, a drug with anti-arrhythmic action. Experimental research on the cardiovascular system].
abstract: It was shown experimentally that mexilithene possesses anti-arrhythmic activity with slight depression of sino-carotid baroreceptorial and glomo-carotid and gangliar chemoreceptorial activity and catecholamine uptake. Hypotensive and bradycardizing effects were only noted when high per kg doses were used. The drug did not display vascular alpha- and beta-adrenolytic, anti-muscarinic and anti-histaminic activity.
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000188:drug therapy; D001794:Blood Pressure / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects*; D002344:Carotid Body / Q000187:drug effects; D002346:Carotid Sinus / Q000187:drug effects; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D006339:Heart Rate / Q000187:drug effects; D008012:Lidocaine / Q000494:pharmacology; D008801:Mexiletine / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D011311:Pressoreceptors / Q000187:drug effects; D011437:Propylamines / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D012119:Respiration / Q000187:drug effects
chemical_list: D011437:Propylamines; D008801:Mexiletine; D008012:Lidocaine
vernacular_title: Il mexilitene, farmaco ad attività antiaritmica. Ricerche sperimentali sull'apparato cardiovascolare.