Antithrombin III and the nephrotic syndrome.
Plasma and urinary antithrombin III (AT-III) was measured in 15 cases of nephrotic syndrome. Plasma AT-III correlated well with serum albumin, but poorly with proteinuria, whereas urinary AT-III correlated well to proteinuria. The plasma AT-III level had a mean similar to 25 healthy controls, but the range was significantly wider. A case with nephrotic syndrome and left renal vein thrombosis is reported. The urinary output of AT-III rose and the plasma level fell with the activity of the disease. Although AT-III and albumin have similar molecule weight, their renal clearance was found to be different. It is suggested that urinary loss of AT-III plays a role in the hypercoagulable state sometimes found in the nephrotic syndrome.
D000293:Adolescent; D000328:Adult; D000419:Albuminuria / Q000097:blood; D000990:Antithrombin III / Q000378:metabolism* / Q000652:urine; D002648:Child; D006801:Humans; D007668:Kidney / Q000378:metabolism; D008297:Male; D009404:Nephrotic Syndrome / Q000150:complications / Q000378:metabolism*; D011507:Proteinuria / Q000097:blood; D012082:Renal Veins; D012709:Serum Albumin / Q000032:analysis; D013927:Thrombosis / Q000150:complications / Q000378:metabolism
D012709:Serum Albumin; D000990:Antithrombin III