The effect of harmine and other monoamine oxidase inhibitors on N-acetyltransferase activity.
Prior studies indicate that the monoamine oxidase inhibitors (MAOI) harmine and iproniazide inhibit N-acetyltransferase activity from liver. In this report we have demonstrated that harmine and harmaline are potent inhibitors of N-acetyltransferase, purified from hamster and rat liver. However, other MAOI such as deprenyl, clorgyline, methysergide, cyproheptadine, phenelzine, pargyline, methyltryptamine and tranylcypromine have either no effect, or only trivial effects on N-acetyltransferase. There is no correlation between a compound's properties as an MAO and N-acetyltransferase inhibitor. One must consider the inhibitory effect of harmine and harmaline on both MAO and N-acetyltransferase when evaluating the effects of these compounds on physiological processes.
D000123:Acetyltransferases / Q000378:metabolism*; D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D006224:Cricetinae; D006247:Harmine / Q000494:pharmacology*; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008647:Mesocricetus; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D051381:Rats
D000470:Alkaloids; D008996:Monoamine Oxidase Inhibitors; D006247:Harmine; D000123:Acetyltransferases