title: On the regulation of antipyrine and oxazepam metabolism in man.
abstract: The metabolism of antipyrine and oxazepam has been measured in twelve healthy subjects. Antipyrine, an analgesic and antipyretic drug, is extensively metabolized by oxidation at various sites and oxazepam, a benzodiazepine, is almost exclusively metabolized by conjugation with glucuronic acid. Comparing the plasma clearance rates and the plasma half lives of the two drugs, correlation coefficients of r = 0.766 (P less than 0.01) and r = 0.966 (P less than 0.01) have been obtained. The data suggests that in man the processes of oxidation and glucuronidation are linked by a common control which regulates the metabolic rates of the two reactions.
mesh_terms: D000983:Antipyrine / Q000097:blood / Q000378:metabolism*; D001711:Biotransformation; D005260:Female; D005965:Glucuronates / Q000378:metabolism; D006207:Half-Life; D006801:Humans; D008297:Male; D010076:Oxazepam / Q000097:blood / Q000378:metabolism*
chemical_list: D005965:Glucuronates; D010076:Oxazepam; D000983:Antipyrine