Inhibition of platelet aggregation by contrast media.
The effect of 30% Urografin on platelet aggregation induced by adenosine diphosphate (ADP), epinephrine, and arachidonic acid was examined. In vivo and in vitro experiments in 10 nondiabetic subjects and in vitro experiments in 7 diabetic-uremic patients showed a statistically significant decrease in platelet aggregation 20 minutes after in vitro incubation or in vivo infusion with Urografin. Urografin concentration was about 2.4-2.5%. The possibility of bleeding induced by contrast media and the connection with acute renal failure in diabetic-uremic patients are discussed.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D001095:Arachidonic Acids / Q000494:pharmacology; D003928:Diabetic Nephropathies / Q000097:blood; D003973:Diatrizoate / Q000031:analogs & derivatives* / Q000494:pharmacology*; D003974:Diatrizoate Meglumine / Q000494:pharmacology*; D004837:Epinephrine / Q000494:pharmacology; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects*; D014511:Uremia / Q000097:blood
D001095:Arachidonic Acids; D003973:Diatrizoate; D003974:Diatrizoate Meglumine; D000244:Adenosine Diphosphate; D004837:Epinephrine