Free fatty acid release from human adipose tissue in relation to obesity -- effect of isoprenaline.
The capacity to release non-esterified acids and glycerol from the abdominal subcutaneous adipose tissue into a medium containing different concentrations of isoprenaline was studied in 21 adults with different body weight (14 obese, 7 controls). The obese had a significantly lower maximum adipokinetic capacity (expressed as pD2) than controls. The significant decrease in pD2 in the obese was found to depend on the stabilization of the weight while the dynamic pD2 stage values of the obese did not differ from those of controls. The hypothesis is expressed that lower pD2 values may be related to the smaller decrease of body fat during weight reduction.
D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism*; D001835:Body Weight; D005230:Fatty Acids, Nonesterified / Q000378:metabolism*; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology*; D008053:Lipid Mobilization / Q000187:drug effects*; D009765:Obesity / Q000378:metabolism*
D005230:Fatty Acids, Nonesterified; D007545:Isoproterenol