Characterization of an irritant 4-deoxyphorbol diester from Euphorbia tirucalli.
Latex of Euphorbia tirucalli, collected in Colombia, yielded 12-O-2Z-4E-octadienoyl-4-deoxyphorbol-13-acetate (1), which exhibited an irritant potency equivalent to that of the standard irritant, phorbol-12-tetradecanoate-13-acetate, in a mouse ear test system. The unsaturated 4-deoxyphorbol diesters recently reported in E. tirucalli grown in South Africa were not observed in the present study.
D000818:Animals; D006868:Hydrolysis; D007509:Irritants; D008297:Male; D051379:Mice; D010703:Phorbol Esters / Q000032:analysis / Q000494:pharmacology*; D010704:Phorbols / Q000494:pharmacology*; D010944:Plants / Q000032:analysis*
D007509:Irritants; D010703:Phorbol Esters; D010704:Phorbols