Withdrawal of chronic chlorpromazine medication: an experimental analysis.
Approximately 50% of all institutionalized, mentally retarded adults receive psychotropic medication to control inappropriate behavior. In this study, behaviors exhibited by five retarded adults were formally observed while they were on and off medication. Each subject had been receiving chlorpromazine for six or more years prior to the start of the study. The drug was withdrawn and readministered using a double-blind B-A-B (drug placebo-drug) design. Effects were highly individualized. Some desirable behavior emerged when chlorpromazine was discontinued.
D000328:Adult; D002746:Chlorpromazine / Q000627:therapeutic use*; D004311:Double-Blind Method; D006801:Humans; D008607:Intellectual Disability / Q000188:drug therapy* / Q000523:psychology; D008297:Male; D008875:Middle Aged; D010919:Placebos; D013375:Substance Withdrawal Syndrome / Q000523:psychology
D010919:Placebos; D002746:Chlorpromazine