Action of tiadenol and clofibrate on biliary excretions of cholesterol and bile salts in rats.
Biliary excretion of cholesterol, phospholipids and bile salts, and the excretion of labeled cholesterol injected intravenously were studied in rats treated for 1 or 3 weeks with the hypolipidemic drugs tiadenol and clofibrate. Total biliary cholesterol concentration and output decreased in treated rats, and the cholesterol solubility ratio increased. The excretion of labeled bile salts increased with both drugs; the excretion of labeled cholesterol increased with clofibrate and tended to decrease with tiadenol. The ratio of labeled bile salts/labeled cholesterol was higher with tiadenol than with clofibrate.
D000818:Animals; D001646:Bile / Q000032:analysis; D001647:Bile Acids and Salts / Q000378:metabolism*; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood / Q000378:metabolism*; D002994:Clofibrate / Q000008:administration & dosage / Q000494:pharmacology*; D005233:Fatty Alcohols / Q000494:pharmacology*; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats; D012636:Secretory Rate / Q000187:drug effects
D001647:Bile Acids and Salts; D005233:Fatty Alcohols; D000960:Hypolipidemic Agents; D010743:Phospholipids; C004568:tiadenol; D002784:Cholesterol; D002994:Clofibrate