Anticonvulsant action in a series of benzimidazole anthelmintics.
In mice, the electroconvulsant threshold was elevated after oral administration of 7 benzimidazole anthelmintics at a dose of 100 mg/kg. This effect was most pronounced with cambendazole which also showed an outstanding duration of action. None of the drugs tested elevated the pentetrazole seizure threshold.
D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D000927:Anticonvulsants; D001562:Benzimidazoles / Q000494:pharmacology*; D004597:Electroshock; D008297:Male; D051379:Mice; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D013997:Time Factors
D000871:Anthelmintics; D000927:Anticonvulsants; D001562:Benzimidazoles; D010433:Pentylenetetrazole