[Determination of the plasma ribonuclease activity as a diagnostic aid in the diagnosis of ovarian cancer. Results of a double blind study (author's transl)].
The determination of the plasmaribonucleases was reported by Sheid and co-workers in 1977 for the diagnosis of carcinoma of the ovary. The authors investigated the accuracy of this test with a modified method in a double blind study encompassing healthy controls. Blood samples from 62 patients with ovarian cancer were tested. The results were accurate in 56 cases. In 6 cases the test results were doubtful. The difference in the ribonuclease activity was significant between patients with ovarian cancer and healthy patients or patients in remission from ovarian cancer. The results were not dependant upon the FIGO staging of the disease. Our results encourage the recommendation to use this test as a diagnostic aid in carcinoma of the ovary.
D004796:Clinical Enzyme Tests; D004311:Double-Blind Method; D005188:False Negative Reactions; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000097:blood*; D012260:Ribonucleases / Q000097:blood*
D012260:Ribonucleases
Bestimmung der Plasmaribonukleaseaktivität als diagnostisches Hilfsmittel zur Erfassung von Ovarialkarzinomen - Ergebnisse einer Doppelblindstudie.