Percutaneous penetration of indomethacin.
14C-Indomethacin (ID) was applied to the skin of guinea-pigs as an ointment. After several applications, the concentration of ID in the skin and muscle under the applied site reached a constant level. The concentration of ID in the muscle as well as the skin may be enough to exert an anti-inflammatory effect.
D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents; D006168:Guinea Pigs; D007213:Indomethacin / Q000008:administration & dosage* / Q000378:metabolism; D009132:Muscles / Q000378:metabolism; D010539:Permeability; D012867:Skin / Q000378:metabolism
D000893:Anti-Inflammatory Agents; D007213:Indomethacin