Dilatometric study of binary mixtures of phosphatidylcholines.
Volumes of lipid dispersions as a function of temperature have been measured for two different kinds of binary mixtures of lecithins, (1) DMPC and DSPC and (2) DMPC and DC20PC. Emphasis was placed on DMPC-rich compositions so as to resolve ambiguities regarding solid-phase immiscibility in DMPC-DSPC mixtures. Special attention has been paid to problems of equilibration in the low-temperature phase and to methods of mixing the lipids. We find that there is no solid-solid immiscibility in DMPC-DSPC mixtures, although this system is close to exhibiting such immiscibility, and that DMPC-DC20PC mixtures exhibit pronounced solid immiscibility.
D007700:Kinetics; D008051:Lipid Bilayers; D008433:Mathematics; D008968:Molecular Conformation; D010713:Phosphatidylcholines; D013329:Structure-Activity Relationship; D013696:Temperature
D008051:Lipid Bilayers; D010713:Phosphatidylcholines