Treatment of Goodpasture's syndrome with immunosuppression and plasmapheresis.
A 14-year-old boy with Goodpasture's syndrome induced by anti-glomerular-basement-membrane (gmb) antibody exhibited declining renal function, in association with a progressive increase in the level of serum anti-GBM antibody. Treatment with prednisone, cyclophosphamide, and plasmapheresis was associated with rapid disappearance of the serum anti-GMB antibody and temporary stabilization of renal function.
D000293:Adolescent; D019867:Anti-Glomerular Basement Membrane Disease / Q000188:drug therapy / Q000276:immunology / Q000628:therapy*; D000906:Antibodies; D001485:Basement Membrane / Q000276:immunology; D003520:Cyclophosphamide / Q000627:therapeutic use*; D006801:Humans; D007678:Kidney Glomerulus / Q000276:immunology; D008297:Male; D010956:Plasmapheresis; D011241:Prednisone / Q000627:therapeutic use*
D000906:Antibodies; D003520:Cyclophosphamide; D011241:Prednisone