[Possible carcinogenic action of chromogen dicarboxidine].
In chronic experiments on 208 rats and 127 mice tne carcinogenic activity of dicarboxidine was examined. The substance was administered percutaneously and by leeding it during two years in the dosage: 20 mg -- 45 mg for rats, 3 mg -- 4 mg for mice. In late terms of the experiment (following one year and a half) the rats developed sarcomas at the site of its injection as well as tumors of other organs, including the urinary bladder. The substance was found to render no appreciable effect on mice. A conclusion is drawn on an insignificant carcinogenic activity of the substance under test, taking into account the late terms of tumors appearance and the induction of tumors only in one species of animals.
D000818:Animals; D001560:Benzidines; D002087:Butyrates; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology; D051381:Rats; D013997:Time Factors
D001560:Benzidines; D002087:Butyrates
Izuchenie vozmozhnogo kantserogennogo deĭstviia khromogenadikarboksidina.