Renal amyloidosis and subcutaneous drug abuse.
Two drug addicts who practiced subcutaneous injection of crushed tripelennamine and pentazocine tablets, a practice known as "skin-popping," developed nephrotic syndrome and demonstrated amyloidosis on renal biopsy. These patients had chronic inflammation of the skin in the form of abscesses and ulcerations. Although both patients were long-standing drug abusers, they had practiced intradermal drug administration for only 3 years. The occurrence of amyloidosis in these patients appears to relate to their particular drug habir and must be considered in the differential diagnosis of proteinuria in this patient population.
D000328:Adult; D000686:Amyloidosis / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D006801:Humans; D007279:Injections, Subcutaneous; D007668:Kidney / Q000473:pathology; D007674:Kidney Diseases / Q000139:chemically induced* / Q000473:pathology; D010423:Pentazocine; D019966:Substance-Related Disorders / Q000150:complications*; D014309:Tripelennamine
D014309:Tripelennamine; D010423:Pentazocine