Effect of prostaglandin F-2 alpha on plasma levels of progesterone and pregnenolone in the hysterectomized guinea-pig.
Repeated injections of PGF-2 alpha were given to hysterectomized guinea-pigs. Within 12 h after the first injection, plasma progesterone levels were significantly reduced (P less than 0.001) and declined to less than 1 ng/ml by the 4th day after the end of PGF-2 alpha treatment. A decline in plasma levels of pregnenolone paralleled that of progesterone. PGF-2 alpha treatment did not affect the metabolic clearance rate of [3H]pregnenolone, but the converions of [3H]pregnenolone to [3H]progesterone was reduced by about 50%.
D000818:Animals; D003864:Depression, Chemical; D005260:Female; D006168:Guinea Pigs; D007044:Hysterectomy; D008657:Metabolic Clearance Rate; D011284:Pregnenolone / Q000097:blood*; D011374:Progesterone / Q000097:blood*; D011460:Prostaglandins F / Q000494:pharmacology*
D011460:Prostaglandins F; D011374:Progesterone; D011284:Pregnenolone