Morphological alteration of the stria vascularis after administration of the diuretic bumetanide.
Chinchillas were given either a single injection of the diuretic bumetanide (18 mg/kg body weight) or saline-sodium hydroxide and sacrificed at 10 min, 1 hr and 24 hr after the injection. Slight stria edema was present at 10 min, marked edema at 1 hr and no edema 24 h after bumetanide. The edema began in the first cochlear turn at 10 min and spread to the second turn by 1 hr. Along with edema, marginal cell bulging, potential capillary constriction and the formation of marginal cell membranous structures occurred after bumetanide treatment.
D000818:Animals; D002034:Bumetanide / Q000008:administration & dosage / Q000494:pharmacology*; D002196:Capillaries / Q000187:drug effects / Q000648:ultrastructure; D002462:Cell Membrane / Q000187:drug effects / Q000648:ultrastructure; D002682:Chinchilla; D003051:Cochlea / Q000187:drug effects*; D004232:Diuretics / Q000494:pharmacology*; D004487:Edema / Q000139:chemically induced / Q000473:pathology; D013316:Stria Vascularis / Q000187:drug effects* / Q000473:pathology
D004232:Diuretics; D002034:Bumetanide