title: [General toxicity and specific action of the herbicide balagrin].
abstract: The influence of the herbicide balagrin on the maternal organism and fetus was experimentally studied on 60 pregnant albino rats of Wistar line. The preparation was given orally throughout the entire gestation period in daily doses of 1/1o - 110 mg/kg, 1/20 - 55 mg/kg and 1/50 - 22 mg/kg of LD50 - 1100 mg/kg. The detoxifying function was studied by the duration of hexabarbital sleep, the excretory function - by the cholic acid content in the bile, and the enzymatic function - by the dehydrogenase activities: LDH, MDH, LDH, GL-6-PDH in the liver of pregnant animals and the fetus, Marked toxic effect on the maternal and fetal organism was demonstrable at all balagrin application levels by the liver function disturbances.
mesh_terms: D000818:Animals; D002793:Cholic Acids / Q000032:analysis; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation / Q000187:drug effects; D005260:Female; D005333:Fetus / Q000187:drug effects; D005704:Gallbladder / Q000032:analysis; D006540:Herbicides / Q000633:toxicity*; D008099:Liver / Q000201:enzymology; D011247:Pregnancy; D051381:Rats; D014052:Toluidines; D014992:Xylenes
chemical_list: D002793:Cholic Acids; D006540:Herbicides; D014052:Toluidines; D014992:Xylenes; C020220:balagrin
vernacular_title: Prouchvane na obshtotoksichnoto i spetsifichnoto deĭstvie na kherbitsida balagrin.