Effect of some peptides on distribution of rifamycin SV in rabbits.
The effect of insulin, glutathione, trypsin and somatotropin on processes of distribution and elimination of rifamycin SV were investigated using pharmacokinetic analysis. It was found that the peptides, especially glutathione and trypsin, enhance the distribution of rifamycin in rabbits and cause an increase of amount of this antibiotic in the central compartment.
D000818:Animals; D005978:Glutathione / Q000494:pharmacology; D007328:Insulin / Q000494:pharmacology; D007700:Kinetics; D008297:Male; D010455:Peptides / Q000494:pharmacology*; D011817:Rabbits; D012294:Rifamycins / Q000378:metabolism*; D013997:Time Factors; D014018:Tissue Distribution / Q000187:drug effects
D007328:Insulin; D010455:Peptides; D012294:Rifamycins; D005978:Glutathione