title: Shark heart mitochondria: effects of external osmolality on respiration.
abstract: Shark mitochondrial respiration was studied in media with osmolalities between 160 and 1500 milliosmoles. The respiratory control ratio, a marker for functional integrity of the isolated mitochondria, was maximal at 1000 millismoles and decreased during hypotonic or hypertonic exposure. Shark mitochondria function best at their native tonicity, a value that produces abnormal function in mammalian mitochondria.
mesh_terms: D000244:Adenosine Diphosphate / Q000378:metabolism; D000818:Animals; D008929:Mitochondria, Heart / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000378:metabolism; D009994:Osmolar Concentration; D010101:Oxygen Consumption; D051381:Rats; D012754:Sharks / Q000378:metabolism*; D013045:Species Specificity
chemical_list: D000244:Adenosine Diphosphate