[Effect of nonachlazine on cerebral circulation].
It has been shown in acute experiments on anesthetized cats that nonachlazine in a dose of 2.5 mg/kg produces a short-term decrease followed by more prolonged elevation of the tone of cerebral vessels, lower extremities and systemic arterial blood pressure. Previous blocking of alpha- and beta-adrenoreceptors decreases or abolishes the development of the above effects. In a dose of 5 mg/kg nonachlazine produces no rise in the tone of intracranial vessels, but increases local and common cerebral blood flow. An increase in PO2 in the brain cortex correlates well with a rise in the blood flow.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D009628:Nonachlazine / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects; D010313:Partial Pressure; D010640:Phenothiazines / Q000494:pharmacology*; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects
D010640:Phenothiazines; D009628:Nonachlazine
Vliianie nonakhlazina na mozgovoe krovoobrashchenie.