Protamines. III. Synthesis of the tetradecapeptide corresponding to the C-terminal sequence 52--65 of galline.
The synthesis of peptides containing blocks of arginyl residues is proposed through amidination of the corresponding ornithyl analogs. In order to test this strategy the ornithyl analog of the C-terminal sequence 52--65 of galline was synthesized by the conventional method. The amidination reaction, performed on fragments of different length and ornithyl-residue content, quantitatively converts ornithines into arginines. The strategy proposed may represent a powerful tool for the synthesis of protamines and other basic proteins.
D000578:Amidines; D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D010446:Peptide Fragments; D010455:Peptides / Q000032:analysis / Q000138:chemical synthesis*; D011479:Protamines / Q000032:analysis / Q000138:chemical synthesis*
D000578:Amidines; D000596:Amino Acids; D010446:Peptide Fragments; D010455:Peptides; D011479:Protamines