[Changes in rabbit thymus lymphoid tissue after administration of pyrogenal and hydrocortisone].
After a single administration of pyrogenal (0.2 and 5 mkg/kg) and hydrocortisone (100 mg/kg) histological changes in the rabbit thymus have been studied and compared with the level of 11-oxycorticosteroids (11-OCS) in blood of the animals under investigation. Hydrocortisone, while producing a considerable rise in the level of 11-OCS, increases the number of degenerating cells, inhibits mitotic activity and decreases the amount of lymphocytes per stipulated area unit in the cortical substance. Changes produced in the thymus after pyrogenal administration are similar to those produced by hydrocortisone administration but are pronounce much weaker, that is connected with concentration of corticosteroids circulating in blood.
D015062:11-Hydroxycorticosteroids / Q000097:blood; D000818:Animals; D002452:Cell Count; D004305:Dose-Response Relationship, Drug; D006854:Hydrocortisone / Q000494:pharmacology*; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D008938:Mitosis / Q000187:drug effects; D011749:Pyrogens / Q000494:pharmacology*; D011817:Rabbits; D013950:Thymus Gland / Q000033:anatomy & histology / Q000166:cytology / Q000187:drug effects*
D015062:11-Hydroxycorticosteroids; D011749:Pyrogens; D006854:Hydrocortisone
Izmeneniia limfoidnoĭ tkani timusa krolikov posle vvedeniia pirogenala i gidrokortizona.