The blood-brain barrier: effects of nonionic contrast media with and without addition of Ca2+ and Mg2+.
Trypan blue and 197HgCl2 were used as markers of the increased leakage through the blood-brain barrier which developed after selective injection of different contrast media formulations into the internal carotid arteries of rabbits. Interest was focused on a new, experimental, nonionic medium (C-29) and possible effects resulting from the addition of Ca2+ and Mg2+ to nonionic contrast media. Using 197Hg, it was possible to quantitate the increase in extravasation produced by the contrast media. C-29 caused less damage than either metrizamide or meglumine iothalamate. The addition of Ca2+ and Mg2+ to nonionic contrast media seemed to stabilize the blood-brain barrier.
D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects*; D002118:Calcium / Q000494:pharmacology*; D003287:Contrast Media / Q000494:pharmacology*; D005260:Female; D007463:Iodobenzoates / Q000494:pharmacology*; D007482:Iothalamate Meglumine / Q000494:pharmacology; D008274:Magnesium / Q000494:pharmacology*; D008297:Male; D008793:Metrizamide / Q000494:pharmacology; D009994:Osmolar Concentration; D011817:Rabbits; D014283:Triiodobenzoic Acids / Q000494:pharmacology*
D003287:Contrast Media; D007463:Iodobenzoates; D014283:Triiodobenzoic Acids; D008274:Magnesium; D008793:Metrizamide; D002118:Calcium; D007482:Iothalamate Meglumine