[Formation of 7-dehydrocholesterol ketoderivative - cholesta-4,7-dien-3-one in stomach and intestinal rat tissues].
Incorporation of [2-14C] sodium acetate into 7-dehydrocholesterol ketoderivative, cholesta-4,7-dien-3-on, was studied in the tissues of the rat stomach secretory and esophageal parts and in the mucous and serous membranes of the small intestine. Cholesta-4,7-dien-3-on is shown to form not from [14C]cholesterol but from [14C] dehydrocholesterol. Incorporation of the label into the compound under study is established to be maximum 6h after isotope administration. The formation of cholesta-4,7-dien-3-on is the most active in the mucous membrane of small intestine and secretory part of the stomach. An assumption is advanced on the relation between the oxidative transformation of 7-dehydrocholesterol and secretion of hydrochloric acid by the animal mucous tissue.
D000818:Animals; D002775:Cholestadienols / Q000378:metabolism*; D002782:Cholestenes / Q000096:biosynthesis*; D002783:Cholestenones / Q000096:biosynthesis*; D002784:Cholesterol / Q000378:metabolism; D003684:Dehydrocholesterols / Q000378:metabolism*; D004947:Esophagus / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism*; D007421:Intestine, Small / Q000378:metabolism; D008297:Male; D010084:Oxidation-Reduction; D051381:Rats
D002775:Cholestadienols; D002782:Cholestenes; D002783:Cholestenones; D003684:Dehydrocholesterols; C019301:cholesta-4,7-dien-3-one; D002784:Cholesterol
Obrazovanie ketopropzvodnogo 7-degidrokholesterina-kholesta-4,7-dien-3-ona v tkaniakh zheludka p kishechnika krys.