Pentagastrin activation of adenylate cyclase in human gastric biopsy specimens.
Adenylate cyclase activity of human fundic mucosa is log-normally distributed and equally stimulated by pentagastrin and histamine. Cimetidine inhibits the histamine, but not the pentagastrin effect, which is even intensified by H2-receptor blockade. The results indicate that pentagastrin and histamine activate adenylate cyclase via distinct receptors.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D002927:Cimetidine / Q000494:pharmacology; D004789:Enzyme Activation / Q000187:drug effects; D005459:Fluorides / Q000494:pharmacology; D005753:Gastric Mucosa / Q000187:drug effects* / Q000201:enzymology; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D010418:Pentagastrin / Q000494:pharmacology*
D002927:Cimetidine; D006632:Histamine; D000262:Adenylyl Cyclases; D010418:Pentagastrin; D005459:Fluorides