Transient liver deterioration induced by general anesthesia.
The disappearance rate of bromsulphthalein (BSP) has been studied in 43 patients before and during vaginal hysterectomy under three kinds of anesthesia: Halothane anesthesia, neuroleptanalgesia, and peridural anesthesia. Furthermore, serum enzymes were measured before and after surgery. The half-life of BSP in the elimination phase is significantly prolonged during general anesthesia but not during the peridural anesthesia in the same procedure. There were slight increases of gamma-glutamyltranspeptidase in the later postoperative days with no changes of transaminases and alkaline phosphatase. It can be concluded that the known post-operative transient liver dysfunction, detected only by the BSP-test, occurs during the performance of surgery and is caused by the influence of the general anesthesia on the intrahepatic cell metabolism and not by the operative procedure itself.
D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000758:Anesthesia / Q000009:adverse effects*; D000767:Anesthesia, Epidural / Q000009:adverse effects; D000769:Anesthesia, Inhalation / Q000009:adverse effects; D001219:Aspartate Aminotransferases / Q000097:blood; D005260:Female; D006207:Half-Life; D006221:Halothane; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008111:Liver Function Tests; D009458:Neuroleptanalgesia / Q000009:adverse effects; D013448:Sulfobromophthalein / Q000378:metabolism
D013448:Sulfobromophthalein; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D006221:Halothane