[Pharmacological properties of a new benzimidazole derivative].
The pharmacological action of the new benziamidazole derivative 1-(3-diethylamino-2-oxypropyl)-2-propylbenzimidazole (abazol) was studied in experiments on mice, dogs, cats and isolated ears of rabbits. In cats and dogs, abazol produces a hypotensive effect and transient reduction of the EEG wave amplitude. Abazol dilates the vessels of an isolated rabbit ear. It shows less toxicity and less pronounced convulsant effect as compared to dibazol.
D000818:Animals; D001562:Benzimidazoles / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D004569:Electroencephalography; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D051379:Mice; D008968:Molecular Conformation; D011817:Rabbits
D001562:Benzimidazoles
O farmakologicheskikh svoĭstvakh novogo proizvodnogo benzimidazola.