title: [Effect of lithium chloride on the thyroid gland of white rats].
abstract: The morphological and functional changes in the thyroid tissue of white rats injected lithium chloride at doses 0.5 mekv/kg and 1.0 mekv/kg (groups 1 and 2, respectively) during three weeks were studied by the radiometric, histological and biochemical methods. The radiometric, histological and biochemical methods. The inhibitory action of lithium chloride on hormonogenesis in the thyroid gland and secretion of thyroid hormones into the blood was proved to be directly related to the lithium dose and concentration in the blood. The data of intravital radiometric and morphological analysis of the organs of the 1st group animals suggest some activization of the gland function, with the secretion of the hormones into the blood being suppressed. Increased concentration of the drug inhibits hormonogenesis and secretion of thyroid hormones into the blood.
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D008094:Lithium / Q000378:metabolism / Q000494:pharmacology*; D008297:Male; D051381:Rats; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000187:drug effects* / Q000378:metabolism; D013963:Thyroid Hormones / Q000096:biosynthesis; D013997:Time Factors
chemical_list: D013963:Thyroid Hormones; D008094:Lithium
vernacular_title: Vliianie khlorida litiia na shchitovidnuiu zhelezu belykh krys.