[Factor analysis of the effectiveness of combined therapy in experimental leukemia].
The effectiveness of the combined therapy of leukemia P-388 with cyclophosphane and diazane was studied. The pattern of administering these substances was selected with due consideration of the cyclospecificity of their action. In a number of cases considerable synergism was observed, resulting in a cure of 100% of animals. Estimation of the effectiveness and the degree of synergism was made by the method of fractionation analysis, which allowed delineating some trends for providing the optimum combined therapy.
D000818:Animals; D001391:Azo Compounds / Q000008:administration & dosage; D003201:Computers; D003520:Cyclophosphamide / Q000008:administration & dosage; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005163:Factor Analysis, Statistical; D007942:Leukemia, Experimental / Q000188:drug therapy*; D051379:Mice; D008815:Mice, Inbred Strains; D013386:Succinates / Q000008:administration & dosage
D001391:Azo Compounds; D013386:Succinates; D003520:Cyclophosphamide
Faktornyĭ analiz éffektivnosti kombinirovannoĭ terapii éksperimental'nykh leĭkozov.