Deletion of the A gamma-globin gene in G gamma-delta beta-thalassemia.
In an individual homozygous for G gamma-delta beta-thalassemia, a physical alteration in gamma-globin gene organization was detected by restriction enzyme mapping. The data indicated that the absence of A gamma-globin chains resulted from extension of the DNA deletion from the delta beta-globin gene region into the gamma-globin gene region rather than a functional disturbance of gamma-gene expression.
D002648:Child; D002872:Chromosome Deletion; D004247:DNA / Q000235:genetics; D005260:Female; D005319:Fetal Hemoglobin / Q000235:genetics; D005796:Genes; D005914:Globins / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D008297:Male; D013789:Thalassemia / Q000097:blood / Q000235:genetics*
D005914:Globins; D004247:DNA; D005319:Fetal Hemoglobin