The localization of [3H]-desipramine in central nerve terminals studied with electron microscope autoradiography and subcellular fractionation.
The cellular and subcellular distribution of [3H]-desipramine (DMI) in rat brain was studied by electron microscope (EM) autoradiography and by subcellular fractionation. A considerable proportion of label was found to be bound to the membranes of presynaptic nerve terminals, as well as to sites inside those terminals.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002421:Caudate Nucleus / Q000378:metabolism / Q000648:ultrastructure; D003891:Desipramine / Q000378:metabolism*; D008297:Male; D008854:Microscopy, Electron; D009186:Myelin Sheath / Q000378:metabolism; D051381:Rats; D011955:Receptors, Drug / Q000378:metabolism; D013347:Subcellular Fractions / Q000378:metabolism; D013569:Synapses / Q000378:metabolism* / Q000648:ultrastructure; D013574:Synaptosomes / Q000378:metabolism* / Q000648:ultrastructure; D014316:Tritium
D011955:Receptors, Drug; D014316:Tritium; D003891:Desipramine