Physiological and pharmacological basis for the chemotherapy of enuresis.
Enuresis is a disorder of micturition occuring in the absence of an organic urinary tract lesion. To understand its possible causation, the mechanisms controlling micturition are described together with the possible sites of action of various anti-enuretic agents, particularly imipramine. It is concluded that further research into the central control of micturition is required before the precise actions of centrally-acting anti-enuretic agents can be elucidated. Knowledge of these may give insight into the nature of the defect causing enuresis.
D000293:Adolescent; D000320:Adrenergic Fibers / Q000187:drug effects / Q000503:physiopathology; D000344:Afferent Pathways / Q000503:physiopathology; D000818:Animals; D002415:Cats; D002648:Child; D002675:Child, Preschool; D004775:Enuresis / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007001:Hypogastric Plexus / Q000187:drug effects; D007099:Imipramine / Q000627:therapeutic use; D008465:Mechanoreceptors / Q000503:physiopathology; D009132:Muscles / Q000294:innervation; D009433:Neural Inhibition / Q000187:drug effects; D011941:Receptors, Adrenergic / Q000187:drug effects / Q000502:physiology; D012018:Reflex / Q000502:physiology; D013116:Spinal Cord / Q000503:physiopathology; D001743:Urinary Bladder / Q000187:drug effects / Q000294:innervation / Q000503:physiopathology; D014554:Urination / Q000187:drug effects*
D011941:Receptors, Adrenergic; D007099:Imipramine