Mepacrine pigmentation in systemic lupus erythematosus. New data from an ultrastructural, biochemical and analytical electron microscopic investigation.
A case of mepacrine pigmentation occurring in a patient with systemic lupus erythematosus has been investigated by fluorescent light microscopy, gas--liquid chromatography and analytical electron microscopy. There is strong evidence for the presence of mepacrine itself within the typical granules, which have been shown by electron microscopy to be membrane bound and intracellular. Analytical electron microscopy also showed that the granules contain large quantities of iron and smaller quantities of sulphur.
D000293:Adolescent; D003594:Cytoplasmic Granules / Q000032:analysis; D005260:Female; D006801:Humans; D007501:Iron / Q000032:analysis; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D008854:Microscopy, Electron; D010859:Pigmentation Disorders / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D011796:Quinacrine / Q000009:adverse effects* / Q000032:analysis / Q000627:therapeutic use; D012867:Skin / Q000032:analysis / Q000648:ultrastructure; D013455:Sulfur / Q000032:analysis
D013455:Sulfur; D007501:Iron; D011796:Quinacrine