Severe hypermotility during sleep in treatment of cataplexy with clomipramine.
A case of narcolepsy with marked cataplexy is described in detail. Clomipramine hydrochloride effectively controlled the cataplexy and partially alleviated the daytime sleep attacks. However, clomipramine treatment resulted in episodes of severe motor hyperactivity during sleep, which were most intense during rapid eye movement sleep.
D002385:Cataplexy / Q000188:drug therapy*; D002997:Clomipramine / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000187:drug effects*; D009290:Narcolepsy / Q000188:drug therapy; D012890:Sleep / Q000187:drug effects*
D002997:Clomipramine