Preferential S-sulfonate formation in lung and aorta.
S-sulfonate (S-SO-3) compounds have previously been identified as metabolites of sulfite in the plasma of several species of mammals [6--8]. We now report the formation of non-diffusible and relatively stable S-sulfonates in the aorta and lung lobes of rabbits exposed intravenously to constant arterial sulfite concentrations of approx. 550 microM. Under these conditions the kinetics of S-SO-3 formation were first order with coefficients in the range of 0.3--0.4 h-1 and asymptotic concentrations of approx. 900 and 9000 nmol S-SO-3/g dry wt. of lung and aorta respectively. The kinetics of this reaction in aorta tissue were closely approximated in vitro. Clearance of S-SO-3 from both lungs and aorta appeared to be first order with a half-life of 2--3 days.
D000818:Animals; D001011:Aorta / Q000378:metabolism*; D066298:In Vitro Techniques; D007263:Infusions, Parenteral; D008168:Lung / Q000378:metabolism*; D008297:Male; D009928:Organ Specificity; D011817:Rabbits; D013447:Sulfites / Q000008:administration & dosage / Q000378:metabolism*; D013451:Sulfonic Acids / Q000378:metabolism*
D013447:Sulfites; D013451:Sulfonic Acids