Humoral regulation of pluripotent stem cell differentiation.
Humoral regulators of CFU-S differentiation have been demonstrated in bone marrow of Ara-C treated animals. These factors are effective in vivo and are also capable of inducing erythropoietic differentiation of normal CFU-S in vitro. These results seem to indicate that the microenvironment acts at the committed stem cell level while the factors described in this paper act on the pluripotent stem cells.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000502:physiology; D001854:Bone Marrow Cells; D002454:Cell Differentiation; D003114:Colony-Forming Units Assay; D003561:Cytarabine / Q000494:pharmacology; D005260:Female; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA
D003561:Cytarabine