The antifertility activity and toxicity of alpha-chlorohydrin derivatives in male rats.
The antifertility activity and toxicity of alpha-chlorohydrin, six derivatives and glycidol were investigated in male rats. At a dose of 5 mg/kg injected intraperitoneally each day for 14 days, only alpha-chlorohydrin produced complete infertility. When rats were injected with the derivatives at a dose equivalent to 5 mg/kg of alpha-chlorohydrin on a molar basis, the phosphorylated and amino acid derivatives produced complete infertility within 7 days; however, there were some signs of toxicity. Compound II also produced complete infertility and appeared less toxic. AY - 22,352, compounds III and IV and glycidol had no antifertility activity, although spermatozoan motility was reduced by injection of glycidol.
D000311:Adrenal Glands / Q000033:anatomy & histology; D000818:Animals; D001835:Body Weight; D002728:Chlorohydrins / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005298:Fertility / Q000187:drug effects*; D007248:Infertility, Male / Q000209:etiology; D007958:Leukocyte Count; D008297:Male; D009929:Organ Size; D051381:Rats; D013081:Sperm Motility / Q000187:drug effects; D000517:alpha-Chlorohydrin / Q000494:pharmacology* / Q000633:toxicity
D002728:Chlorohydrins; D000517:alpha-Chlorohydrin