Nonlinear cable equations for axons. II. Computations and experiments with external current electrodes.
We have investigated the steady-state potential and current distributions resulting from current injection into a close-fitting channel into which a squid axon is placed. Hybrid computer solutions of the cable equations, using the Hodgkin-Huxley equations to give the membrane current density, were in good agreement with experimental observations. A much better fit was obtained when the Hodgkin-Huxley leakage conductance was reduced fivefold.
D000818:Animals; D001369:Axons / Q000502:physiology*; D003203:Computers, Hybrid; D049832:Decapodiformes / Q000502:physiology*; D004553:Electric Conductivity; D004594:Electrophysiology; D008433:Mathematics; D008959:Models, Neurological