Inhibition of human leucocytes locomotion by anti-inflammatory drugs.
In this study we have demonstrated that acidic non-steroidal anti-inflammatory drugs in low concentrations inhibited human PMN locomotion in vitro. A speculative mechanism of action is proposed.
D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology; D002465:Cell Movement / Q000187:drug effects; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D003864:Depression, Chemical; D006801:Humans; D007052:Ibuprofen / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D007660:Ketoprofen / Q000494:pharmacology; D009288:Naproxen / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects; D012459:Salicylates / Q000494:pharmacology
D000893:Anti-Inflammatory Agents; D012459:Salicylates; D009288:Naproxen; D007660:Ketoprofen; D001241:Aspirin; D007052:Ibuprofen; D007213:Indomethacin