HLA system and testicular germinative tumours.
In 62 patients with testicular germinative tumours and 301 healthy unrelated subjects, 23 HLA antigens of A and B loci were tested. In the group of 40 seminomas the incidence of HLA-Bw35 antigen and in 22 patients with non-seminomas (embryonal carcinomas, teratocarcinoma and mixed forms) the frequency of HLA-A 10 antigen were significantly higher (27.50 vs. 14.28% in the controls, p greater than 0.025; 36.36 vs. 15.28%, p less than 0.025). After correction by multiplying p by the number of typed antigens there was no statistically significant result any more. The causes of dubious results of the studies about the association between HLA and malignancies are discussed.
D004407:Dysgerminoma / Q000276:immunology*; D005787:Gene Frequency; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000209:etiology; D013223:Statistics as Topic; D013724:Teratoma / Q000276:immunology*; D013736:Testicular Neoplasms / Q000276:immunology*
D006680:HLA Antigens