Estradiol metabolism by liver homogenates and microsomes of normal and cirrhotic male rats.
Incubation experiments show that homogenates and microsomes obtained from CCl4-induced cirrhotic livers of male rats metabolize an estradiol load at a much slower rate than preparations from normal livers. The decreased metabolic capacity results in a slower disappearance of estradiol from the incubation medium, and in a slower transformation of metabolized estradiol to polar extractable and to highly polar nonextractable metabolites.
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000378:metabolism; D004958:Estradiol / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced*; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism*; D051381:Rats
D004958:Estradiol