Ectopic functioning adrenocortico-myelolipoma in longstanding Nelson's syndrome.
A 26-year-old man with the Nelson's syndrome is described, in whom an abdominal tumour developed, accompanied by recurrent Cushing's syndrome 11 years after total adrenalectomy. Upon removal the tumour was a myelolipoma containing islands of adrenocortical-like elements. On incubation of the tumour with radioactive precursors, its capacity to produce cortisol in vitro was shown. The name adrenocortico-myelolipoma is suggested for this tumour.
D000008:Abdominal Neoplasms / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D000302:Adrenal Cortex / Q000378:metabolism / Q000473:pathology; D000315:Adrenalectomy; D000328:Adult; D002828:Choristoma; D003480:Cushing Syndrome / Q000209:etiology; D006729:Hormones, Ectopic; D006801:Humans; D006854:Hydrocortisone / Q000096:biosynthesis; D066298:In Vitro Techniques; D008297:Male; D009347:Nelson Syndrome / Q000150:complications*; D009384:Paraneoplastic Endocrine Syndromes; D010911:Pituitary Neoplasms / Q000150:complications*; D055728:Primary Myelofibrosis / Q000209:etiology* / Q000378:metabolism / Q000473:pathology
D006729:Hormones, Ectopic; D006854:Hydrocortisone