Goodpasture's syndrome--effects of plasmapheresis.
Two patients with Goodpasture's syndrome, who underwent plasmapheresis are presented. One patient received prednisone but the other patient received no concomitant cytotoxic therapy. Results indicate that plasmapheresis reduces morbidity in patients with Goodpasture's syndrome. The possible mode of action of plasmapheresis is discussed. The use of cytotoxic  therapy as an adjunct to plasmapheresis may not be necessary since the anti-GBM production appears to be a self-limiting process.
D000328:Adult; D019867:Anti-Glomerular Basement Membrane Disease / Q000276:immunology / Q000628:therapy*; D000906:Antibodies / Q000032:analysis; D001485:Basement Membrane / Q000276:immunology; D003176:Complement C3 / Q000032:analysis; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007678:Kidney Glomerulus / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010956:Plasmapheresis
D000906:Antibodies; D003176:Complement C3; D007136:Immunoglobulins