title: CI-867, a new broad-spectrum semisynthetic penicillin.
abstract: The synthesis and antimicrobial activity of a new semisynthetic penicillin are described. Both in vitro and in vivo, the compound shows promising antibacterial activity when compared with piperacillin and ticarcillin. High activity is shown against Pseudomonas and other Gram-negative bacteria.
mesh_terms: D000818:Animals; D051379:Mice; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000138:chemical synthesis* / Q000494:pharmacology; D011552:Pseudomonas Infections / Q000188:drug therapy
chemical_list: D010406:Penicillins