The effect of long-term use of cimetidine on the ultrastructure of gastric parietal cells in man.
The effect of long-term cimetidine therapy on the ultrastructure of human parietal cells was investigated in 2 subjects. It was found that after cimetidine therapy for 1 year: (i) the ultrastructural appearance of the parietal cells was normal, and (ii) the parietal cells responded normally to stimulation by pentagastrin. Evidence in favour of a membrane flow mechanism involved in acid secretion is presented.
D002927:Cimetidine / Q000494:pharmacology*; D006146:Guanidines / Q000494:pharmacology*; D006801:Humans; D013270:Stomach / Q000187:drug effects / Q000648:ultrastructure*
D006146:Guanidines; D002927:Cimetidine