[Interaction of acrylonitrile with the microsomal oxidation system of the rat liver].
A complex with unusual spectral properties was formed after interaction of acrylonitrile with microsomal cytochrome P-450. In the absorption spectrum of the complex the minimum was observed at 400-410 nm but no distinct absorption maxima were found. Acrylonitrile stimulated utilization of oxygen during oxidation of NADP and inhibited hydroxylation of p-nitroanizol and N-demethylation of dimethylaniline. The data obtained suggest possibility of interaction of acrylonitrile with the microsomal system of oxidation.
D000181:Acrylonitrile / Q000378:metabolism / Q000494:pharmacology*; D000814:Aniline Compounds / Q000494:pharmacology; D000818:Animals; D000840:Anisoles / Q000494:pharmacology; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004347:Drug Interactions; D006900:Hydroxylation; D008297:Male; D008748:Methylcholanthrene / Q000494:pharmacology; D008862:Microsomes, Liver / Q000187:drug effects*; D009570:Nitriles / Q000494:pharmacology*; D010084:Oxidation-Reduction; D010634:Phenobarbital / Q000494:pharmacology; D011485:Protein Binding / Q000187:drug effects; D051381:Rats
D000814:Aniline Compounds; D000840:Anisoles; D009570:Nitriles; D008748:Methylcholanthrene; D003577:Cytochrome P-450 Enzyme System; D000181:Acrylonitrile; D010634:Phenobarbital
Vzaimodeístvie akrilonitrila s sistemoĭ mikrosomal'nogo okisleniia pecheni krys.