[Effect of proteolysis inhibitors on the phagocytic activity and the cytoplasmic enzymatic activity in the leukocytes of white mice].
The injection of proteolytic inhibitors changes phagocytosis and metabolism of leucocytes in different ways. The polyvalent inhibitor, inhitril, increased phagocytosis but does not change digestive activity of leucocytes. Activities of acid phosphatase, peroxidases and succinatedehydrogenase as well as glycogen contents are seen decreased, whereas activity of glycerophosphate dehydrogenase increases, and that of lactate dehydrogenase does not change. Anti-tryptic serum decreases phagocytosis, both digestive and enzymatic activities of leucocytes, glycogen accumulation being observed. Anti-kallikrein serum decreases phagocytosis and activity of lactate dehydrogenase, and does not change glycogen accumulation and activities of digestion and of acid phosphatase. In addition, activities of succinate-, glycerophosphate dehydrogenase and peroxidase increase.
D000818:Animals; D003593:Cytoplasm / Q000187:drug effects* / Q000201:enzymology; D004789:Enzyme Activation / Q000187:drug effects; D006003:Glycogen / Q000378:metabolism; D006019:Glycolysis / Q000187:drug effects; D007962:Leukocytes / Q000187:drug effects* / Q000201:enzymology; D010088:Oxidoreductases / Q000378:metabolism; D010587:Phagocytosis / Q000187:drug effects*; D011480:Protease Inhibitors / Q000494:pharmacology*; D051381:Rats
D011480:Protease Inhibitors; D006003:Glycogen; D010088:Oxidoreductases
Vliianie ingibitorov proteoliza na fagotsitarnuiu aktivnost' i aktivnost' tsitoplazmaticheskikh fermentov leĭkotsitov belykh mysheĭ.