title: Percutaneous absorption in experimental epidermal disease.
abstract: Little is known about the absorption of topical drugs in epidermal disease associated with epidermal proliferation and altered keratinization. An abnormal hairless mouse epidermis was produced by three different methods: ultraviolet light irradiation, topical vitamin A acid and topical acetic acid. An increased epidermal thickness resulted and the in vitro percutaneous absorption of 0.1% (4-14C) hydrocortisone was found to be increased when compared with normal hairless mouse epidermis. This is evidence for defective skin barrier function in experimental epidermal disease.
mesh_terms: D000818:Animals; D001699:Biometry; D004817:Epidermis / Q000378:metabolism / Q000473:pathology; D005260:Female; D006854:Hydrocortisone / Q000378:metabolism; D051379:Mice; D012867:Skin / Q000473:pathology; D012869:Skin Absorption; D012871:Skin Diseases / Q000378:metabolism* / Q000473:pathology
chemical_list: D006854:Hydrocortisone