beta-Oxidation of the coenzyme A esters of vaccenic, elaidic, and petroselaidic acids by rat heart mitochondria.
Rates of beta-oxidation of the coenzyme A esters of vaccenic, elaidic, and petroselaidic acids as well as their respective cis isomers by rat heart mitochondria were measured and compared. At all concentrations studied, vaccenoyl-CoA was oxidized more rapidly than elaidoyl-CoA, but more slowly than oleoyl-CoA except at high substrate concentrations. All trans octadecenoyl-CoA esters were oxidized at a slower rate than their respective cis or saturated isomers. Oxidation rates decreased as the double bond approached the carboxyl-end.
D000214:Acyl Coenzyme A / Q000378:metabolism*; D000818:Animals; D007700:Kinetics; D008297:Male; D008929:Mitochondria, Heart / Q000378:metabolism*; D010084:Oxidation-Reduction; D051381:Rats; D013329:Structure-Activity Relationship
D000214:Acyl Coenzyme A