Lithium transport across red cell membrane: a cell membrane abnormality in manic-depressive illness.
In the families of manic-depressive patients, relatives with a history of affective disorders had a significantly higher ratio of mean red cell lithium to plasma lithium in vitro than relatives with no such history. A genetically controlled abnormality in lithium-sodium transport, the mechanism that determines the lithium ratio, may play a role in the etiology of some forms of affective disorders.
D001692:Biological Transport; D001714:Bipolar Disorder / Q000097:blood / Q000235:genetics / Q000378:metabolism*; D002414:Cations, Monovalent / Q000378:metabolism; D004910:Erythrocyte Membrane / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D008094:Lithium / Q000097:blood*; D010375:Pedigree; D012964:Sodium / Q000097:blood
D002414:Cations, Monovalent; D008094:Lithium; D012964:Sodium