title: Central action of new derivatives of tetrahydropirimidinedione-4,6.
abstract: The central action and LD50 of 11 new 2,5-substituted derivates of tetrahydropirimidinedione-4,6 with an aryl group at C2 were investigated. The most favorable action was exerted by 2-furfurylamine derivatives with an alkil or benzyl group at C5. These compounds acted in doses of 0.0025--0.01 of their LD50 synergistically with chloral hydrate and strongly with hexobarbital, delayed convulsions induced with pentetrazole and potentiated the central action of DOPA in mice pargyline-inhibited MAO activity. They did not antagonize electrogenic convulsions, amphetamine potentiated motility and the action of reserpine, and had no analgetic action. Their LD50s were 670-- 1660 mg/kg.
mesh_terms: D000661:Amphetamine / Q000494:pharmacology; D000700:Analgesics; D000818:Animals; D001921:Brain / Q000187:drug effects*; D002697:Chloral Hydrate / Q000494:pharmacology; D004357:Drug Synergism; D005260:Female; D005663:Furans / Q000494:pharmacology; D006591:Hexobarbital / Q000494:pharmacology; D007980:Levodopa / Q000494:pharmacology; D008297:Male; D051379:Mice; D009068:Movement / Q000187:drug effects; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D011744:Pyrimidinones / Q000494:pharmacology*; D012110:Reserpine / Q000037:antagonists & inhibitors; D012640:Seizures; D012890:Sleep / Q000187:drug effects
chemical_list: D000700:Analgesics; D005663:Furans; D011744:Pyrimidinones; D002697:Chloral Hydrate; D007980:Levodopa; D012110:Reserpine; D006591:Hexobarbital; D000661:Amphetamine; D010433:Pentylenetetrazole