The role of thyronine in thyroid hormone metabolism.
Thryonine (T0) has been identified in human urine using gas chromatography-mass fragmentography (G.C.M.F.). In 22 normal individuals urinary T0 concentration was found to range between 8--25 nmol/24h. Assuming the mean normal thyroxine (T4) production rate to be approximately 100 nmol/24h, our findings indicate that less than 20% of this could be accounted for as urinary T0 excretion, thus supporting earlier findings that the peripheral metabolism of T4 is not limited solely to deiodination.
D002849:Chromatography, Gas; D006801:Humans; D013058:Mass Spectrometry; D013961:Thyroid Gland / Q000378:metabolism; D013970:Thyronines / Q000652:urine*; D013974:Thyroxine / Q000378:metabolism*
D013970:Thyronines; D013974:Thyroxine