Olivanic acids, a family of beta-lactam antibiotics with beta-lactamase inhibitory properties produced by Streptomyces species. I. Detection, properties and fermentation studies.
The screening of soil actinomyces for beta-lactamase inhibitors is described. Using a plate test a number of strains of Streptomyces were found to produce beta-lactamase inhibitory activity designated olivanic acid complex. Factors affecting the production of this complex by Streptomyces olivaceus ATCC 21379 are reported. The complex showed antibacterial activity and also inhibited a number of different types of beta-lactamase in a progressive manner. Certain ampicillin-resistant bacteria are rendered sensitive to ampicillin in the presence of olivanic acid complex at a concentration which alone did not inhibit growth.
D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000494:pharmacology; D005285:Fermentation; D013302:Streptomyces / Q000378:metabolism*; D013997:Time Factors; D065093:beta-Lactamase Inhibitors; D047090:beta-Lactams / Q000032:analysis / Q000096:biosynthesis / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D065093:beta-Lactamase Inhibitors; D047090:beta-Lactams