Does a barbiturate drug given in lethal dose enter the cornea?
We wished to see whether sodium phenobarbital (one of the commonest drugs used to commit suicide) given in a lethal dose would enter the cornea. Guinea pigs and rabbits were killed with an overdose of the drug. Using gas chromatography we were able to detect the drug not only in the vascular ocular tissues and the intraocular fluids but also in the avascular tissues such as the cornea.
D000818:Animals; D003315:Cornea / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D006168:Guinea Pigs; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D008297:Male; D010634:Phenobarbital / Q000008:administration & dosage / Q000378:metabolism / Q000506:poisoning*; D011817:Rabbits
D010634:Phenobarbital