Psychotropic drugs as behavioral teratogens.
Three psychotropic drugs were administered to pregnant rats and were then evaluated for their behavioral and reproductive effects in the offspring. Control rats received either saline or vitamin A. Prochlorperazine had the most disruptive effects on reproduction and growth, but had the least effect on behavior. Propoxyphene had no apparent effects on reproduction or growth, but produced a variety of behavioral changes. Fenfluramine was intermediate in its effects on reproduction and growth and had behavioral effects that were revealed in tests of preweaning development. The data suggest that systematic tests of behavior add important information to evaluations of reproductive toxicity that cannot, at present, be obtained by other means.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001923:Brain Chemistry / Q000187:drug effects; D011431:Dextropropoxyphene / Q000494:pharmacology*; D004195:Disease Models, Animal; D005260:Female; D005277:Fenfluramine / Q000494:pharmacology*; D006801:Humans; D008098:Litter Size / Q000187:drug effects; D008297:Male; D009069:Movement Disorders / Q000139:chemically induced; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D011346:Prochlorperazine / Q000494:pharmacology*; D051381:Rats; D012098:Reproduction / Q000187:drug effects; D012744:Sex Ratio / Q000187:drug effects; D013550:Swimming
D005277:Fenfluramine; D011431:Dextropropoxyphene; D011346:Prochlorperazine