Toxicological study of Semecarpus anacardium nut extract.
Toxicological study was carried out in rats with chloroform-soluble fraction of the nuts of Semecarpus anacardium to determine its safe non-toxic dose. The fraction produced toxicity at all levels tested (50-400 mg/kg) but the extent of toxicity was found dose-dependent. At lower doses this fraction induced partial growth inhibition over 36 days and higher doses proved fatal within 6 days. It was observed that 230 mg/kg caused 50% mortality in rats and this value is 1380 mg/m2 when expressed for body surface area. This work will be of some use in the cancer chemotherapy study of the fraction.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D007928:Lethal Dose 50; D008297:Male; D009754:Nuts; D010936:Plant Extracts / Q000633:toxicity*; D010946:Plants, Medicinal; D051381:Rats; D013997:Time Factors
D010936:Plant Extracts