title: Leukocyte migration inhibition activity of nonimmune acute inflammatory pleural exudate.
abstract: Material with leuckocyte migration inhibition (LMI) activity has been demonstrated in various types of nonimmunologically induced acute pleural inflammatory exudates. This activity is present in inflammatory cell-free exudate and appears to involved the deposition of fibrin around the migrating leukocyte, resulting in "cell-trapping." This is supported by the fact that removal or inhibition of fibrin formation leads to loss of exudate LMI activity. Both fibrinogen and complement as well as vitamin K-dependent clotting factors appear to be required for LMI activity. The mechanism involved in the LMI reaction and its significance in nonimmune and cell-mediated immune inflammation are discussed.
mesh_terms: D000818:Animals; D002464:Cell Migration Inhibition; D005337:Fibrin / Q000502:physiology; D006493:Heparin / Q000494:pharmacology; D006358:Hot Temperature; D006882:Hydroxyapatites / Q000494:pharmacology; D007249:Inflammation / Q000276:immunology*; D007509:Irritants / Q000494:pharmacology; D007962:Leukocytes / Q000276:immunology*; D008297:Male; D010996:Pleural Effusion / Q000032:analysis / Q000276:immunology*; D051381:Rats; D013917:Thrombin / Q000494:pharmacology; D014859:Warfarin / Q000494:pharmacology; D015054:Zymosan / Q000494:pharmacology
chemical_list: D006882:Hydroxyapatites; D007509:Irritants; D014859:Warfarin; D005337:Fibrin; D006493:Heparin; D015054:Zymosan; D013917:Thrombin