[Induction of gastrointestinal tract tumors in rats with N-methyl-N-nitro-N-nitrosoguanidine (MNNG)].
Tumors of the gastrointestinal tract were induced in white non-inbred rats exposed to MNNG in various doses. Gastric tumors appeared in the dosage of 153 mg, with its 2 and 3.3 times increase no change in the frequency of gastric tumors was noted. The frequency of jejunal tumors was higher with increased MNNG dosage.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005770:Gastrointestinal Neoplasms / Q000139:chemically induced*; D007414:Intestinal Neoplasms / Q000139:chemically induced; D007421:Intestine, Small; D008297:Male; D008769:Methylnitronitrosoguanidine; D009374:Neoplasms, Experimental / Q000139:chemically induced; D051381:Rats; D013274:Stomach Neoplasms / Q000139:chemically induced; D013997:Time Factors
D008769:Methylnitronitrosoguanidine
Induktsiia opukholeĭ zheludochno-kishechnogo trakta u krys N-metil-N-nitro-N-nitrozoguanidinom.