L-Threonine deaminase as a possible antitumor agent.
In vitro studies with L-threonine deaminase purified from sheep liver demonstrated that the enzyme was cytotoxic toward two lines of murine leukemia cells but not toward L cells or normal human fibroblasts. When L-threonine deaminase was injected into mice, it was possible to lower the plasma L-threonine concentration by 90%. The enzyme had a half-life of 1.5 hours in the circulation.
D000818:Animals; D000970:Antineoplastic Agents; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D005347:Fibroblasts; D006801:Humans; D007739:L Cells / Q000187:drug effects; D007942:Leukemia, Experimental / Q000188:drug therapy*; D051379:Mice; D013912:Threonine / Q000097:blood; D013913:Threonine Dehydratase / Q000097:blood / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D013912:Threonine; D013913:Threonine Dehydratase