[Effect of light deprivation on GABA metabolism in subcellular fractions of the rabbit visual system].
Specific activity of glutamate decarboxylase was decreased in subfractions of light and heavy synaptosomes, and gamma-aminobutyric acid (GABA) transaminase activity--also in subfractions of free mitochondria, isolated from visual zone of brain cortex and of anterior mesencephalon but not from locomotive region of brain cortex of the light-deprived rabbits. Decrease in the ratio GABA transaminase/glutamate decarboxylase indicated distinct inhibition of GABA degradation as compared with its synthesis due to absence of sensory impulsation within the early periods of postnatal ontogenesis of the animals.
D000818:Animals; D003624:Darkness / Q000009:adverse effects*; D004789:Enzyme Activation; D005968:Glutamate Decarboxylase / Q000378:metabolism; D008928:Mitochondria / Q000201:enzymology; D009044:Motor Cortex / Q000378:metabolism; D011817:Rabbits; D013347:Subcellular Fractions / Q000378:metabolism; D013574:Synaptosomes / Q000201:enzymology; D000637:Transaminases / Q000378:metabolism; D014793:Visual Cortex / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D005680:gamma-Aminobutyric Acid; D000637:Transaminases; D005968:Glutamate Decarboxylase
Vliianie svetovoĭ deprivatsii na obmen GAMK v subkletochnykh fraktsiiakh zritel'noĭ sistemy krolikov.