title: A preliminary report on the use of warfarin in the treatment of navicular disease.
abstract: Twenty horses suffering from navicular disease were treated with warfarin given orally. The dosage was to effect, to give a 2 to 4 second prolongation of the one stage prothrombin time (OSPT). Dosage was initially at a rate of 0.018 mg/kg, changing the dose by amounts of 20 per cent until the required dose was achieved. Final dose rates varied from 0.012 mg/kg to 0.75 mg/kg. All the cases treated received warfarin daily throughout the trial. Seventeen of the animals became sound and the remaining 3 showed a marked improvement in their gait. The mean of the ages of the horses was 7.5 years, the mean of the periods of lameness 9 months and the mean of the time taken to recovery one treatment was commenced was 7 weeks.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D005534:Foot Diseases / Q000188:drug therapy / Q000662:veterinary*; D005552:Forelimb; D006406:Hematoma / Q000139:chemically induced / Q000662:veterinary; D006734:Horse Diseases / Q000139:chemically induced / Q000188:drug therapy*; D006736:Horses; D010000:Osteitis / Q000188:drug therapy / Q000662:veterinary*; D014859:Warfarin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D014859:Warfarin