Ventilation and chemoreflexes during enflurane sedation and anaesthesia in man.
Enflurane sedation and anaesthesia in healthy fit subjects reduced ventilation and the response to carbon dioxide, hypoxaemia and a low dose of doxapram, all in a dose-related fashion. Comparing the three chemoreflexes tested, the response to hypoxaemia and doxapram were the more profoundly impaired; they were nearly totally abolished by anaesthesia. These effects of enflurane on chemoreflex activities are qualitatively similar to those previously observed with halothane.
D000293:Adolescent; D000328:Adult; D000758:Anesthesia; D002245:Carbon Dioxide / Q000097:blood; D002628:Chemoreceptor Cells / Q000187:drug effects*; D004315:Doxapram / Q000494:pharmacology; D004737:Enflurane / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives; D008297:Male; D010100:Oxygen / Q000097:blood; D012018:Reflex / Q000187:drug effects*; D012119:Respiration / Q000187:drug effects*
D006993:Hypnotics and Sedatives; D002245:Carbon Dioxide; D004737:Enflurane; D004315:Doxapram; D010100:Oxygen