Prostaglandin E1 inhibits acute cell dehydration thirst.
Intraperitoneally injected PGE1 (100 micrograms/Kg) inhibits specifically the drinking induced by both IP and IV 2 M NaCl (6 ml/Kg) and compound 48/80 (100 micrograms/Kg, IP). Probenecid (150 mg/Kg, IP) which is not a dipsogen, has no effect on the PGE1 induced inhibition of acute cell dehydration thirst. It is concluded the PGE1 acts upon the peripheral mast cells, inhibiting their secretion and thus affecting the water intake associated with the activation of these cells either by hypertonicity or specific stimulants of amine release. These results raise the possibility that endogenous prostaglandins might be involved in the modulation of some of the signals which convey to the brain information on the tonicity of the body fluids.
D000818:Animals; D003681:Dehydration / Q000523:psychology*; D008297:Male; D008407:Mast Cells / Q000378:metabolism; D011339:Probenecid / Q000494:pharmacology; D011458:Prostaglandins E / Q000494:pharmacology*; D011460:Prostaglandins F / Q000494:pharmacology; D051381:Rats; D013894:Thirst / Q000187:drug effects*; D013997:Time Factors; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D011458:Prostaglandins E; D011460:Prostaglandins F; D003189:p-Methoxy-N-methylphenethylamine; D011339:Probenecid