[Examination of hormonal contraceptives by enzyme induction (author's transl)].
The influence of drug stimulated biotransformation on the biological effectiveness of two different contraceptives (Deposition and Gravistat) was observed.--Phenobarbital, a potent enzyme inducer, is known to increase the metabolism of steroid hormones, including estrogens and progrestogens. -- The clinical symptoms of drug mediated enzyme induction of hormonal steroid contraceptives are dysfunctional bleedings. This phenomenon is discussed.
D000328:Adult; D001711:Biotransformation; D003276:Contraceptives, Oral / Q000494:pharmacology*; D003278:Contraceptives, Oral, Hormonal / Q000378:metabolism / Q000494:pharmacology*; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D006801:Humans; D008598:Menstruation / Q000187:drug effects; D010634:Phenobarbital
D003276:Contraceptives, Oral; D003278:Contraceptives, Oral, Hormonal; D010634:Phenobarbital
Zur Prüfung hormonaler Kontrazeptiva durch medikamentöse Enzyminduktion.