title: Dexamethasone effect on the phospholipid content of isolated fat cell ghosts from adrenalectomized rats.
abstract: The lipid composition of sonicated ghosts from isolated fat cells has been investigated. Epididymal fat cells from adrenalectomized rats were incubated with and without 8 x 10(-8) M dexamethasone for 3 h. Phospholipids and cholesterol were isolated from membrane ghosts prepared from these cells. There was a 61% increase in membrane sphingomyelin from cells incubated with dexamethasone (P less than 0.025). No significant change was observed in other phospholipids, cholesterol, or fatty acid components of the phospholipids.
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects* / Q000648:ultrastructure; D000315:Adrenalectomy; D000818:Animals; D002462:Cell Membrane / Q000032:analysis / Q000187:drug effects; D002784:Cholesterol / Q000032:analysis; D003907:Dexamethasone / Q000494:pharmacology*; D005227:Fatty Acids / Q000032:analysis; D008297:Male; D010743:Phospholipids / Q000032:analysis*; D051381:Rats; D013109:Sphingomyelins / Q000032:analysis
chemical_list: D005227:Fatty Acids; D010743:Phospholipids; D013109:Sphingomyelins; D003907:Dexamethasone; D002784:Cholesterol