TLC differentiation of butyrophenone and diphenylbutylpiperidine compounds from phenothiazine derivatives.
A procedure is described for TLC detection and differentiation of the butyrophenone-diphenylbutylpiperidine group and phenothiazine derivatives at the microgram level. A two-dimensional TLC method to separate butyrophenone and diphenylbutylpiperidine compounds is reported. A variety of possible detection reagents were examined. The solvent systems and spray reagents described should be useful for the identification of these drugs in various dosage forms.
D002090:Butyrophenones / Q000032:analysis*; D002855:Chromatography, Thin Layer / Q000379:methods; D005484:Fluspirilene / Q000032:analysis; D007202:Indicators and Reagents; D010395:Penfluridol / Q000032:analysis; D010640:Phenothiazines / Q000032:analysis*; D010868:Pimozide / Q000032:analysis; D010880:Piperidines / Q000032:analysis*
D002090:Butyrophenones; D007202:Indicators and Reagents; D010640:Phenothiazines; D010880:Piperidines; D010868:Pimozide; D010395:Penfluridol; D005484:Fluspirilene