Ichthyosis linearis circumflexa Comèl and Netherton's syndrome; an ultrastructural study.
An electron microscopic study of 3 cases of ichthyosis linearis circumflexa Comèl (ILC) reveals the presence of round bodies in the prickle cells: a characteristic feature of ILC. The horny and the granular layers are absent and are replaced by parakeratotic cells with condensed cytoplasm, which an amorphous material dissociates. The early formation of a vesiculopustule is detected. The importance of the dermal inflammation is considered and it is stated that ILC is not a purely epidermal disorder of keratinization.
D000293:Adolescent; D002648:Child; D003593:Cytoplasm / Q000648:ultrastructure; D005260:Female; D006197:Hair / Q000002:abnormalities; D006801:Humans; D007057:Ichthyosis / Q000473:pathology*; D008297:Male; D008854:Microscopy, Electron; D012867:Skin / Q000473:pathology* / Q000648:ultrastructure; D013577:Syndrome