Reactogenicity and immunogenicity of a surface-antigen-adsorbed influenza virus vaccine in children.
An influenza virus vaccine containing the purified surface haemagglutinin and neuraminidase antigens of A/Victoria/75 and B/Hong Kong/73 viruses adsorbed to an aluminium hydroxide gel was assessed for reactogenicity and immunogenicity in children aged 4 to 11 years, since there is no influenza virus vaccine available for this age group. Significant serum haemagglutination-inhibiting antibody responses to the A/Victoria/75 and B/Hong Kong/73 haemagglutinin antigens present in the vaccine were observed in 47% and 35%, respectively, of the children vaccinated, with a single dose. The vaccine induced no significant local or systemic reactions.
D000914:Antibodies, Viral / Q000032:analysis; D000954:Antigens, Surface / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007252:Influenza Vaccines / Q000276:immunology*; D007251:Influenza, Human / Q000517:prevention & control; D008297:Male; D009975:Orthomyxoviridae / Q000276:immunology; D014611:Vaccination
D000914:Antibodies, Viral; D000954:Antigens, Surface; D007252:Influenza Vaccines