[Prilocaine as an hypotensive ocular agent (author's transl)].
The purpose of the present investigation was to determine the action of prilocaine as hypotensive ocular agent. Prilocaine in doses of 2.5 mg/kg, 5 mg/kg and 10 mg/kg was administered intravenously in dogs anesthetized with sodium pentobarbital (30 mg/kg). The experiments show that prilocaine when used i.v. in doses of 2.5 mg/kg and 5 mg/kg causes ocular hypotension in dogs, whereas doses of 10 mg/kg i.v. produce this effect only when artificial respiration is employed, thus preventing the increase of the pCO2 in the blood.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002245:Carbon Dioxide / Q000097:blood; D004285:Dogs; D005260:Female; D007275:Injections, Intravenous; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D011318:Prilocaine / Q000008:administration & dosage / Q000494:pharmacology*; D012121:Respiration, Artificial; D013997:Time Factors
D011318:Prilocaine; D002245:Carbon Dioxide
Estudo da ação da prilocaína como agente hipotensor ocular.