Self-stimulation of the sulcal prefrontal cortex in the rat: direct evidence for ascending dopaminergic mediation.
Intracranial self-stimulation (ICSS) of the prefrontal cortex dorsal to the rhinal sulcus in rats has been abolished by means of injections of 6-hydroxydopamine (6-OHDA) (4 micrograms/2 microliters) into the ascending trajectory of the A10 mesocortical dopaminergic fibers ipsilateral to the stimulation electrodes. Similar injections made contralateral to the stimulation electrodes produced a transient attenuation of this self-stimulation. All cases of such lesions were confirmed with the use of Vibratome histochemical fluorescence examination of each of the dopamine projection areas in the forebrain.
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology*; D004298:Dopamine / Q000502:physiology; D004558:Electric Stimulation; D006892:Hydroxydopamines / Q000494:pharmacology*; D008297:Male; D008856:Microscopy, Fluorescence; D051381:Rats; D012653:Self Stimulation
D006892:Hydroxydopamines; D004298:Dopamine