title: [Premedication of esophago-gastro-duodenoscopy with a neuroleptanalgesic drug and a tranquillizer--a controlled clinical study (author's transl)].
abstract: In a controlled double-blind randomized study Thalamonal and Valium were compared in 498 esophago-gastro-duodenoscopies. Both drugs were injected intravenously immediately before the procedure. Satisfactory sedation which made additional injection of the drug during the endoscopy superfluous could be achieved in 66% of the patients with Thalamonal and in 52% with Valium respectively. The difference between the two preparations is statistically significant (p less than 0,005). In 95 patients catamnestic studies were performed in order to evaluate second episodes of fatigue after the endoscopy. A good effect of the preparation during endoscopy and a lack of second attacks of sedation following discharge was observed only in 23% of the patients after Thalamonal and in 21% of the patients after Valium injection, respectively. Therfore a good premedication was achieved in only one fifth of the patients receiving one of the two drugs.
mesh_terms: D003975:Diazepam; D004311:Double-Blind Method; D004329:Droperidol; D004378:Duodenal Diseases / Q000175:diagnosis; D004724:Endoscopy; D004945:Esophagoscopy; D005069:Evaluation Studies as Topic; D005283:Fentanyl; D005773:Gastroscopy; D006801:Humans; D007275:Injections, Intravenous; D008875:Middle Aged; D009458:Neuroleptanalgesia; D011292:Premedication
chemical_list: D004329:Droperidol; D003975:Diazepam; D005283:Fentanyl
vernacular_title: Neuroleptanalgesie und Tranquilizer als Prämedikation bei der Osophago-Gastro-Duodenoskopie--Eine kontrollierte klinische Studie.