[Pharmacokinetics of the antiviral preparation, bonafton].
The parameters of bonafton pharmacokinetics (absorption, distribution, excretion) have been studied in male Wistar rats at single enteral and intraperitoneal administration. With these routes of administration daily resorption amounts to 26 and 100%, respectively. Regardless administration routes 14C-bonafton distributes in a similar way in the internal organs and tissues and is excreted through the kidneys and gastrointestinal tract, the latter way of excretion being predominant. T1 = 0.25 day (24%) and T2 = 1.8 day. A two-chamber model of the drug metabolism is suggested. This model allows a calculation of bonafton and its metabolites accumulation at repeated administration of the drug to the body.
D000042:Absorption; D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D008433:Mathematics; D008954:Models, Biological; D009285:Naphthoquinones / Q000008:administration & dosage / Q000378:metabolism*; D051381:Rats; D013997:Time Factors; D014018:Tissue Distribution
D000998:Antiviral Agents; D009285:Naphthoquinones
Farmakokinetika protivovirusnogo preparata bonaftona.