Effects of metronidazole on certain functions of human blood neutrophils and lymphocytes.
The effects of metronidazole at varying concentrations (10(-7)M - 10(-2)M) on certain cellular immune functions were assessed in vitro. Neutrophil chemotaxis to endotoxin-activated autologous serum, random motility and postphagocytic metabolic activity (hexose monophosphate shunt activity, myeloperoxidase-mediated protein iodination and glycolysis) were unaffected. Likewise, metronidazole had no detectable effects on lymphocyte-active E-rosette formation, mitogen-induced DNA synthesis and mitogen-induced protein synthesis.
D001798:Blood Proteins / Q000096:biosynthesis; D002465:Cell Movement / Q000187:drug effects; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis; D006019:Glycolysis / Q000187:drug effects; D006801:Humans; D007455:Iodine / Q000097:blood; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000502:physiology*; D008795:Metronidazole / Q000494:pharmacology*; D008934:Mitogens / Q000494:pharmacology; D009504:Neutrophils / Q000502:physiology*; D010587:Phagocytosis / Q000187:drug effects; D011485:Protein Binding; D012397:Rosette Formation
D001798:Blood Proteins; D008934:Mitogens; D008795:Metronidazole; D004247:DNA; D007455:Iodine