Inhibition of liver protein degradation in vivo by intensive treatment with cycloheximide.
The AA in experiments performed on male rats treated with 0,5 mCi/kg of cycloheximide have observed an inhibition of liver protein degradation and have suggested two mechanism: 1) cycloheximide prevents the acute proteolytic response induced in fibroblast culture by exposure to serum-deficient media and in rat livers after perfusion probably by inhibiting the lysosomal - autophagic system, without modifications in total activity of lysosome proteinases. 2) It may be that protein degradation rate and level of lysosomal proteinases reinterrelated; the latter probably being a factor controlling the overall cell protein turnover rate.
D000818:Animals; D002403:Cathepsins / Q000378:metabolism; D003513:Cycloheximide / Q000494:pharmacology*; D005215:Fasting; D006867:Hydrolases / Q000378:metabolism; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008247:Lysosomes / Q000201:enzymology; D008297:Male; D009929:Organ Size; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D013997:Time Factors
D011506:Proteins; D003513:Cycloheximide; D006867:Hydrolases; D002403:Cathepsins