Synthesis of antibodies and immunoglobulins bearing recipient allotypic markers and donor idiotypic specificities in irradiated rabbits grafted with allogeneic cells from hyperimmune donors.
Irradiated rabbits were grafted with a mixture of bone marrow, lymph node and spleen cells from donors hyperimmunized against TMV. Recipient and donors were characterized by different a allotypic specificities. Antibodies synthesized in the recipients display allotypic markers from the recipients but idiotypic specificities cross-reactive with those of donor antibodies. The results show that the differentiation of new host B cells is influenced by the presence of donor memory cells and are interpreted in the light of network concepts.
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D001666:Binding Sites, Antibody; D003429:Cross Reactions; D006168:Guinea Pigs; D007106:Immune Sera; D007126:Immunoglobulin Allotypes; D007130:Immunoglobulin Idiotypes; D007136:Immunoglobulins / Q000096:biosynthesis*; D017710:Lymphocyte Transfusion; D011817:Rabbits; D013154:Spleen / Q000276:immunology; D014027:Tobacco Mosaic Virus / Q000276:immunology; D014184:Transplantation, Homologous; D014965:X-Rays
D000914:Antibodies, Viral; D007106:Immune Sera; D007126:Immunoglobulin Allotypes; D007130:Immunoglobulin Idiotypes; D007136:Immunoglobulins