alpha-Melanocyte-stimulating hormone: reduction in adult rat brain after monosodium glutamate treatment of neonates.
Intraperitoneal injection of monosodium glutamate in neonatal rates resulted in a 90 percent loss of alpha-melanocyte-stimulating hormone in hypothalamic and extrahypothalamic areas of the brain, whereas the amount of hormone in the pituitary gland did not change. The dramatic reduction of alpha-melanocyte-stimulating hormone in the brain suggests that is primary source there is the neuronal perikarya of the arcuate nucleus.
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000378:metabolism*; D005971:Glutamates / Q000494:pharmacology*; D009074:Melanocyte-Stimulating Hormones / Q000378:metabolism*; D051381:Rats; D012970:Sodium Glutamate / Q000494:pharmacology*
D005971:Glutamates; D009074:Melanocyte-Stimulating Hormones; D012970:Sodium Glutamate