GFA expression in aggregation cultures of rat C6 glioma.
Few C6 glioma cells synthesize the astroglia-specific GFA protein in monolayer culture. A uniform population of GFA-positive cells was obtained by aggregation C6 cells in suspension culture, as previously reported for C6 glioma maintained on sponge foam matrices. These results strongly suggest that cell-to-cell interactions promote GFA expression.
D000818:Animals; D002449:Cell Aggregation; D002460:Cell Line; D005910:Glioma / Q000378:metabolism*; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D051381:Rats
D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins