title: Lysozyme sensitivity of pantothenate-deficient Lactobacillus plantarum grown with exogenous fatty acids.
abstract: A pantothenic acid deficiency in Lactobacillus plantarum reduces lipid synthesis, prevents normal uptake and retention of extracellular amino acids and markedly increases sensitivity of these cells to lysozyme induced lysis. Pantothenate-deficient cells provided with exogenous fatty acids synthesize additional lipids and express nearly normal solute transport activities. The present study has shown that such cells retain a heightened sensitivity to lysozyme induced lysis. These observations indicate that the lysozyme sensitivity of pantothenate-deficient cells is not produced as in indirect effect of membrane lipid depletion, but represents an independent consequence of pantothenate insufficiency.
mesh_terms: D005227:Fatty Acids / Q000378:metabolism*; D007778:Lactobacillus / Q000187:drug effects / Q000378:metabolism*; D008055:Lipids / Q000096:biosynthesis; D009113:Muramidase / Q000494:pharmacology*; D010205:Pantothenic Acid / Q000494:pharmacology*
chemical_list: D005227:Fatty Acids; D008055:Lipids; D010205:Pantothenic Acid; D009113:Muramidase