title: [Aminazine distribution in the organs and tissues of rats depending on the routes of administration and the age of the animals].
abstract: Distribution of intramuscular and oral aminazin (20 mg/kg) in the brain, lungs, liver, kidneys, heart, ileum, blood and urine was studied in young and old male rats. Intramuscular drug showed maximal accumulation in the lungs and intestine, respectively, whereas at oral administration maximal and minimal accumulation was recorded in the liver and kidneys. Urine excretion of parenteral aminazin was 4-7-fold higher as compared to oral administration. Delayed accumulation of aminazin in the organs and its decreased excretion with urine were recorded in old animals.
mesh_terms: D000375:Aging / Q000187:drug effects*; D000818:Animals; D002746:Chlorpromazine / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D008297:Male; D051381:Rats; D013997:Time Factors; D014018:Tissue Distribution / Q000187:drug effects
chemical_list: D002746:Chlorpromazine
vernacular_title: Raspredelenie aminazina v organakh i tkaniakh krys v zavisimosti ot puteĭ vvedeniia i vozrasta zhivotnykh.