Potentiation of anticancer effect of carboquone in vivo by glucose pretreatment.
Anticancer effect of carboquone was notably potentiated in tumor-bearing mice when they were pretreated with 5% glucose solution in the system of blood flow-interrupting hyperthermic chemotherapy. It was further found by quantitative analysis that the potentiation was much greater than increase in the general toxicity of the drug by administration of glucose. Mitomycin-C, on the other hand, revealed no such marked effect though it is considerably similar to carboquone in chemical structure.
D000818:Animals; D001389:Azirines / Q000627:therapeutic use*; D002225:Carbazilquinone / Q000627:therapeutic use*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy*; D004357:Drug Synergism; D005947:Glucose / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008937:Mitomycins / Q000494:pharmacology
D001389:Azirines; D008937:Mitomycins; D002225:Carbazilquinone; D005947:Glucose