Comparative effects of delta 9-tetrahydrocannabinol, tetrabenazine and chlorpromazine on rectal temperature in the rat.
Tetrabenazine evoked a biphasic response in rectal temperature of the rat following intraperitoneal administration of 4.4--70.0 mg/kg. The initial hyperthermia was inversely related to the dose while the subsequent hypothermia was dose-dependent. This biphasic effect on temperature was similar to that seen with THC at 0.5 mg/kg, thus adding further evidence of a similarity in the mode of action of the two drugs. In contrast, only hypothermia was evident following chlorpromazine administration.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D002746:Chlorpromazine / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D013759:Dronabinol / Q000008:administration & dosage / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D051381:Rats; D012007:Rectum; D013747:Tetrabenazine / Q000008:administration & dosage / Q000494:pharmacology*
D013759:Dronabinol; D002746:Chlorpromazine; D013747:Tetrabenazine