Evidence for presynaptic cholinergic receptors on dopaminergic terminals: degeneration studies with 6-hydroxydopamine.
Intraventricular injections of 6-hydroxydopamine (6-OHDA) caused a significant decrease in the tyrosine hydroxylase of striatal synaptosomes of rats, without influencing GABA levels. Significant decreases in the muscarinic and nicotinic receptors also occurred in this preparation after 3 days. The receptors were measured by specific binding studies with N-methylatropine and alpha-bungarotoxin respectively. These results indicate that muscarinic and nicotinic receptors are located on the dopaminergic nerve terminals of corpus striatum.
D000818:Animals; D001285:Atropine / Q000378:metabolism; D001286:Atropine Derivatives; D002038:Bungarotoxins / Q000378:metabolism; D003342:Corpus Striatum / Q000032:analysis* / Q000502:physiology*; D004298:Dopamine / Q000502:physiology*; D005260:Female; D009411:Nerve Endings / Q000032:analysis; D051381:Rats; D011950:Receptors, Cholinergic / Q000032:analysis* / Q000378:metabolism; D011976:Receptors, Muscarinic / Q000032:analysis; D011978:Receptors, Nicotinic / Q000032:analysis
D001286:Atropine Derivatives; D002038:Bungarotoxins; D011950:Receptors, Cholinergic; D011976:Receptors, Muscarinic; D011978:Receptors, Nicotinic; D001285:Atropine; D004298:Dopamine