[Pharmacological properties of some vinyl derivatives of quinoline].
Toxicity, radioprotective and antiinflammatory properties of 20 vinyl derivatives of quinoline and products of their transformations were studied in experiments on Wistar mice and rats. The salts of quinoline vinyl derivatives (compounds VI, IX, XII, and XVIII) were shown to be more toxic than respective initial compounds (VI, VIII, XI and XVI). 8-(beta-Butylthio)-ethyloxyquinoline (compound IV) protected 25% of irradiated mice from death. Compounds I, XII, XVI and XVIII exerted a radioprotective action (in 10-15%), whereas the remaining substances proved ineffective. The combination of 8-vinyloxyquinoline and iodine (compound IV) elicited a marked antiinflammatory action in experimental serotonin-, dextran- and to a less measure formalin-induced inflammation.
D000818:Animals; D000893:Anti-Inflammatory Agents; D005260:Female; D007928:Lethal Dose 50; D051379:Mice; D011804:Quinolines / Q000494:pharmacology* / Q000633:toxicity; D011837:Radiation-Protective Agents; D014753:Vinyl Compounds / Q000494:pharmacology* / Q000633:toxicity
D000893:Anti-Inflammatory Agents; D011804:Quinolines; D011837:Radiation-Protective Agents; D014753:Vinyl Compounds
Farmakologicheskie svoĭstva nekotorykh vinil'nykh proizvodnykh khinolina.