Cellular immunity in renal diseases.
Cellular immune reactivity was studied in 78 patients with various forms of renal disease by skin testing with four recall antigens and a lymphocyte transformation test with tuberculin PPD and leucoagglutinin. Patients with S-creatine greater than or equal to 230 micromol/l as well as those with chronic pyelonephritis who had S-creatinine values below 230 micromol/l had significantly lower skin reactions than the controls to streptokinase-streptodornase, parotitis and PPD. Glomerulonephritic patients with S-creatinine values below 230 micromol/l had normal skin reactivity. Lymphocyte transformation tests showed decreased reactivity only in patients with S-creatinine level greater than or equal to 230 micromol/l. The results suggest an association of chronic pyelonephritis with a defective efferent, nonspecific arm of cellular immunity.
D000328:Adult; D003404:Creatinine / Q000097:blood; D005921:Glomerulonephritis / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D007674:Kidney Diseases / Q000276:immunology*; D008213:Lymphocyte Activation; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000276:immunology; D011704:Pyelonephritis / Q000276:immunology; D012882:Skin Tests
D003404:Creatinine