Serum amyloid P-component levels in amyloidosis, connective tissue diseases, infection, and malignancy as compared to normal serum.
A highly sensitive radioimmunoassay was developed to measure the serum levels of SAP. Sera from 50 normal individuals ranging in age from 4 to 89 years had a mean level of 7.47 mg/dl and showed no variations with age. Sera from persons with various clinical types of amyloidosis, connective tissue diseases, and bacterial pneumonia did not differ significantly from normal values. A significant difference was noted in the sera from persons with malignancy, where a mean value of 10.79 mg/dl was determined. Although a number of similarities exist between SAP and CRP, SAP does not share the property of being an acute-phase reactant.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000682:Amyloid / Q000378:metabolism*; D000686:Amyloidosis / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D003095:Collagen Diseases / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood*; D011014:Pneumonia / Q000097:blood*; D011863:Radioimmunoassay / Q000379:methods; D000685:Serum Amyloid A Protein / Q000378:metabolism*
D000682:Amyloid; D000685:Serum Amyloid A Protein