[Study of the effect of dopamine on renal excretion in chronic renal failure (author's transl)].
The effects of dopamine on renal excretory function were studied in 20 patients with chronic renal failure (plasma creatinine higher than 30 mg/i). Effects were marked at a dose of 2 micrograms/kg/mn and were no greater at a dose of 5 micrograms/kg/mn (10 subjects in each case). In general, creatinine clearance increased by 28%, urea excretion by 45%, urine output by 77% and urinary sodium output by 164%. In ten patiens with terminal renal failure (plasma creatinine greater than 100 mg/i), the effects of dopamine were maintained. In these individuals, furosemide (250 mg by single intravenous injection) resulted in a higher total urine and urinary sodium output but had a less favourable effect upon creatinine.
D000328:Adult; D000368:Aged; D003404:Creatinine / Q000378:metabolism; D004298:Dopamine / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004573:Electrolytes / Q000652:urine; D005260:Female; D005665:Furosemide / Q000494:pharmacology / Q000627:therapeutic use; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D007676:Kidney Failure, Chronic / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009318:Natriuresis / Q000187:drug effects; D014508:Urea / Q000378:metabolism; D014554:Urination / Q000187:drug effects
D004573:Electrolytes; D005665:Furosemide; D014508:Urea; D003404:Creatinine; D004298:Dopamine
Effets de la dopamine sur l'excrétion rénale dans i'insuffisance rénale chronique.