title: Coordinated rhythmic bursting in respiratory and locomotor muscle nerves in the spinal rabbit.
abstract: In unanaesthetized, curarized spinal rabbits (C2 level) treated with Niamide and DOPA, rhythmic activities were recorded from the phrenic nerves; close coordination was observed between the phrenic bursts and the locomotor bursts which developed in hindlimb muscle nerves. The frequency of phrenic bursts was reduced after a second spinal transection at the Th12 level, while rhythms in the hindlimb remained unchanged. It thus appears that in the spinal preparation and under certain pharmacological conditions, phrenic bursts generated by the cervico-thoracic spinal cord can be driven by the lumbar generators of locomotion; spinal links thus exist between these hindlimb locomotion generators and spinal interneuronal networks involved in phrenic motoneuronal activation, may be via hindlimb forelimb driving.
mesh_terms: D000818:Animals; D002541:Cerebral Decortication; D003655:Decerebrate State / Q000503:physiopathology; D004594:Electrophysiology; D006614:Hindlimb / Q000294:innervation*; D007980:Levodopa / Q000494:pharmacology; D008124:Locomotion; D009526:Nialamide / Q000494:pharmacology; D010507:Periodicity; D010791:Phrenic Nerve / Q000502:physiology; D011817:Rabbits; D012119:Respiration; D013116:Spinal Cord / Q000187:drug effects / Q000502:physiology*; D013127:Spinal Nerves / Q000502:physiology*
chemical_list: D007980:Levodopa; D009526:Nialamide