title: [Coagulation problems associated with massive blood transfusions. An experimental study (author's transl)].
abstract: During storage banked blood show changes as far as function and concentration of their corpuscular and plasmatic ingredients are concerned. Antihaemophilic globulin (factor VIII) and pro-accelerin (factor V) in particular lose their activities so quickly that only very few activities still remain after a storage period of 3-5 days. In connection with existing primary diseases but also in trauma and shock a dilution-coagulopathy caused by insufficient supply of factors VIII and V can develop during massive transfusion, and this especially with banked blood already stored over a longer period of time. Therapy of this disturbance of coagulation consists of substituting the missing coagulation factors under heparin protection.
mesh_terms: D001778:Blood Coagulation Disorders / Q000628:therapy*; D001780:Blood Coagulation Tests; D001793:Blood Preservation / Q000592:standards*; D001803:Blood Transfusion; D005165:Factor V / Q000032:analysis / Q000627:therapeutic use; D005169:Factor VIII / Q000032:analysis / Q000627:therapeutic use; D006801:Humans
chemical_list: D005165:Factor V; D005169:Factor VIII
vernacular_title: Gerinnungsprobleme bei Massivtransfusionen. Eine experimentelle Studie.