[Iodine overloads in amniotic fluids (author's transl)].
The mean of total iodine levels in amniotic fluid samples is 7.8 ng/ml during the middle of pregnancy and 4.4 ng at the end. On about 200 samples collected at random from high risk pregnant women, 14% fluid contain iodine load. This iodine excess comes from water-soluble iodinated drugs administrated to the pregnant women; most are less than 300 ng/ml but 24 hours after urography the load reaches 80,000 times the mean value. Biochemical analyses have shown the iodine excess was iodide, easely released. In our study no neonatal hypothyroidism was noticed probably because that degradation. However administration of any iodinated drug to pregnant women may be a risk to the fetus.
D000653:Amniotic Fluid / Q000032:analysis*; D005260:Female; D005332:Fetoscopy / Q000009:adverse effects; D005333:Fetus / Q000187:drug effects; D006801:Humans; D007037:Hypothyroidism / Q000139:chemically induced / Q000209:etiology; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000139:chemically induced / Q000209:etiology; D007454:Iodides / Q000008:administration & dosage / Q000032:analysis; D007455:Iodine / Q000009:adverse effects / Q000032:analysis*; D011247:Pregnancy; D014567:Urography / Q000009:adverse effects
D007454:Iodides; D007455:Iodine
Surcharges iodées de liquides amniotiques.