title: Differential pulse polarography of tetracycline: determination of complexing tendencies of tetracycline analogs in the presence of cations.
abstract: The complexation tendencies, stoichiometries, and stability constants for tetracycline, minocycline, and demeclocycline with the metallic ions calcium(II), magnesium (II), zinc(II), aluminum(III), iron(II), and iron (III) were evaluated using a polarographic technique. Changes in pulse peak heights for each tetracycline deravative were measured as a function of cation concentration. The method provides an in vitro method of evaluating the selectivity of particular metal ions for different tetracycline analogs.
mesh_terms: D000535:Aluminum; D002118:Calcium; D055598:Chemical Phenomena; D002621:Chemistry; D007501:Iron; D008274:Magnesium; D011048:Polarography; D013752:Tetracycline; D013754:Tetracyclines; D015032:Zinc
chemical_list: D013754:Tetracyclines; D000535:Aluminum; D007501:Iron; D013752:Tetracycline; D008274:Magnesium; D015032:Zinc; D002118:Calcium