A fatal case of inappropriate ADH secretion induced by cyclophosphamide therapy.
Cyclophosphamide is used extensively to treat malignancies. A 5-year-old boy with stage IV neuroblastoma is described who developed a fatal syndrome of inappropriate antidiuretic hormone (ADH) secretion after high dose cyclophosphamide therapy.
D000310:Adrenal Gland Neoplasms / Q000188:drug therapy; D002675:Child, Preschool; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007177:Inappropriate ADH Syndrome / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D009447:Neuroblastoma / Q000188:drug therapy; D010904:Pituitary Gland, Posterior / Q000473:pathology; D012965:Sodium Chloride / Q000008:administration & dosage; D013997:Time Factors
D012965:Sodium Chloride; D003520:Cyclophosphamide