title: In vivo evaluation of monopolar intravascular PO2 electrodes.
abstract: Ten intravascular electrodes were evaluated on ten rabbits. The mean stabilized time of 118 +/- 52 min was excessively long for clinical use. The in vitro cal factor was not reproducible nor accurate. The differences between the PO2 values measured by the electrode and those obtained from intermittent blood samples were within +/- 10 mm Hg during the first 12 hr using the in vivo calibration after electrode stabilization. After 12 hr, the electrode PO2 values using the in vitro cal factor or based upon the in vivo calibration were increased significantly indicating a possible membrane rupture. This occured more rapidly in the animal experiments than in the in vitro studies using a tonometer, suggesting that continuous flow and pressure changes inside of the aorta contribute greatly to mechanical breakage of the membrane. Histologic evaluation indicated the electrode catheter system was thrombogenic at the level of the electrode tip and this thrombogenicity was primarily related to intimal injury caused by the electrode tip movement as a result of flow and pressure changes inside the aorta.
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001808:Blood Vessels / Q000033:anatomy & histology; D002712:Chlorides / Q000494:pharmacology; D004567:Electrodes, Implanted; D005069:Evaluation Studies as Topic; D006046:Gold / Q000494:pharmacology; D008297:Male; D008991:Monitoring, Physiologic / Q000295:instrumentation* / Q000379:methods; D010100:Oxygen / Q000097:blood*; D011817:Rabbits; D012834:Silver / Q000494:pharmacology
chemical_list: D001672:Biocompatible Materials; D002712:Chlorides; D012834:Silver; D006046:Gold; D010100:Oxygen