[The pharmacokinetics of nalidixic acid administered parenterally. Towards rational use in severe infections (author's transl)].
Nalidixic acid is effective toward Gram negative infections but its short half-life and potential neurological toxicity explain that its parenteral use is hazardous. Interindividual variations of its pharmacokinetic parameters explain also the absolute necessity of a careful drug monitoring adapted to each patient. The study of plasma kinetics of a single dose of nalidixic acid injected by intravenous route, shows these metabolic variations. With this results, the predicted plasma drug concentrations show that classical dosage regimens are adapted only to a little number of patients. Advantages and inadequacies of a single daily intravenous infusion of nalidixic acid are next analysed.
D001424:Bacterial Infections / Q000188:drug therapy*; D006207:Half-Life; D006801:Humans; D007263:Infusions, Parenteral; D007275:Injections, Intravenous; D009268:Nalidixic Acid / Q000008:administration & dosage / Q000378:metabolism* / Q000627:therapeutic use
D009268:Nalidixic Acid
Pharmacocinétique de l'acide nalidixique administré par voie parentérale. Pour une utilisation rationnelle dans les infections graves.