[Plasmodium chabaudi: changes in the surface sialic acids of red blood cells during infection (author's transl)].
Surface sialic acids of mice red blood cells infected with the malarial parasite Plasmodium chabaudi are increased as compared to extracts of red cells from normal mice. This increase occurs coincidentally when reticulocytes increase in the peripheral blood. The same increase of surface sialic acids is shown by studies of reticulocytes from phenylhydrazine treated mice. Similarly, neutral hexoses, fucose, were found in greater quantities in surface glycopeptides obtained after incubation with trypsin of reticulocytes from phenylhydrazine treated mice than in surface glycopeptides of red cells from normal mice. This increase occurs also in Plasmodium chabaudi infected red cells with the development of reticulocytosis, in the same way. These facts suggest the contribution of reticulocytes to the biochemical changes observed during malaria infection.
D000818:Animals; D004906:Erythrocyte Count; D004910:Erythrocyte Membrane / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism* / Q000382:microbiology; D008288:Malaria / Q000097:blood*; D008297:Male; D051379:Mice; D010659:Phenylhydrazines / Q000494:pharmacology; D010961:Plasmodium / Q000254:growth & development; D012156:Reticulocytes / Q000378:metabolism; D012794:Sialic Acids / Q000097:blood*
D010659:Phenylhydrazines; D012794:Sialic Acids
Plasmodium chabaudi: modification des acides sialiques de surface des hématies au cours de l'infestation.