title: Indomethacin increases abortifacient effect of PGE2 in man.
abstract: Results of this study indicate that pretreatment with indomethacin significantly increases the abortifacient effect of an intravenous infusion of PGE2 in patients admitted for abortion as a result of fetal death in utero. Indomethacin pretreatment shortened the duration of PGE2-induced abortion in primigravid and multigravid groups of patients by about 4 and 2 hours respectively. When primigravid and multigravid groups were combined, the dose of PGE2 needed for complete delivery decreases in the indomethacin-treated group by 39.9%.
mesh_terms: D000019:Abortifacient Agents; D000028:Abortion, Induced; D000328:Adult; D004357:Drug Synergism; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology*; D007263:Infusions, Parenteral; D010298:Parity; D011247:Pregnancy; D011458:Prostaglandins E / Q000008:administration & dosage; D013997:Time Factors; D014590:Uterine Contraction / Q000187:drug effects
chemical_list: D000019:Abortifacient Agents; D011458:Prostaglandins E; D007213:Indomethacin