On the lipid granularity of renomedullary interstitial cells in benign and malignant courses of renal hypertension.
The number of lipid droplets of the renal medullary interstitial cells was registered in 40 rats with "two-kidney Goldblatt hypertension" and in 27 sham operated normotensive controls. A strong degranulation in the unclaimed kidneys was always associated with the malignant course of hypertension, characterized by a disturbance in the sodium and water balance. Giving 2 per cent saline in addition to demineralized water as a drinking fluid the decrease in the number of granules was prevented in most of the malignant cases. Significant changes in the granule count were never registered at a benign course of hypertension. Degranulation of the medullary interstitial cells in the unclamped kidneys does not unequivocally represent the loss of medullary antihypertensive function. It seems to be directly determined by the disturbance of sodium and water balance and indirectly by the hypertension.
D000818:Animals; D001835:Body Weight; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D006974:Hypertension, Malignant / Q000473:pathology*; D006977:Hypertension, Renal / Q000473:pathology*; D006978:Hypertension, Renovascular / Q000473:pathology*; D007679:Kidney Medulla / Q000473:pathology / Q000648:ultrastructure*; D008055:Lipids / Q000032:analysis*; D008297:Male; D011453:Prostaglandins / Q000378:metabolism; D051381:Rats; D014882:Water-Electrolyte Balance
D008055:Lipids; D011453:Prostaglandins