Effect of a forced diuresis on the distribution and excretion (via urine and bile) of 195mplatinum when given as 195mplatinum cis-dichlorodiammineplatinum(II).
195mPlatinum cis-dichlorodiammineplatinum(II) (195mPt cis-DDP) was injected iv with furosemide or mannitol into male Sprague-Dawley rats. The effect of such a diuresis on the distribution, excretion, and retention of cis-DDP was measured. The mannitol-treated animals had a significant increase in the urinary excretion of 196mPt over control animals for the first five 15-minute collection times and for the 24-hour cumulative urine for the 0.01-mg/kg dose. At the 6-mg/kg dose, only the first three 15-minute and 24-hour cumulative urine collections were significant. This increased excretion, however, did not affect tissue or blood concentrations of this agent. Furosemide did not affect the excretion of 195mPt. A biliary excretion of 195mPt given as 195mPt cis-DDP is documented. The excretion is biphasic, with a rapid phase followed by a slower protracted phase. Forced diuresis, if it affords renal protection, does so during the first 90 minutes of urinary excretion.
D000818:Animals; D001646:Bile / Q000378:metabolism; D002945:Cisplatin / Q000008:administration & dosage* / Q000378:metabolism / Q000652:urine; D004231:Diuresis; D004347:Drug Interactions; D005665:Furosemide / Q000008:administration & dosage; D007275:Injections, Intravenous; D007668:Kidney / Q000187:drug effects; D008297:Male; D008353:Mannitol / Q000008:administration & dosage; D010984:Platinum / Q000378:metabolism*; D011868:Radioisotopes; D051381:Rats; D014018:Tissue Distribution
D011868:Radioisotopes; D008353:Mannitol; D010984:Platinum; D005665:Furosemide; D002945:Cisplatin