title: [Gonadotoxic action of acetylsalicylic acid].
abstract: It has been established in experiments on white rats that administration of acetylsalicylic acid (ASA) in a dose of 1/10 LD50 for 1 1/2 months is accompanied by a decrease in the functional activity of spermatozoids. Repeated inhalation of ASA dust at a concentration of 25 mg/m3 for 4 months produces morphological changes in the spermatogenic epithelium and abnormal antenatal development of the progeny of male animals under test.
mesh_terms: D000818:Animals; D001241:Aspirin / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004622:Embryo, Mammalian / Q000187:drug effects; D004781:Environmental Exposure; D005260:Female; D008297:Male; D011247:Pregnancy; D051381:Rats; D012098:Reproduction / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects; D013737:Testis / Q000187:drug effects*; D013997:Time Factors
chemical_list: D001241:Aspirin
vernacular_title: O gonadotoksicheskom deĭstvii atsetilsalitsilovoĭ kisloty.