title: Metabolic mapping of functional activity in the hypothalamo-neurohypophysial system of the rat.
abstract: Physiological stimulation of the hypothalamo-neurohypophysial system by salt loading of rats resulted in a dramatically increased glucose utilization in the posterior pituitary but not in the paraventricular or supraoptic nuclei. The good correlation between glucose utilization and neural activity in the posterior pituitary (that is, nerve terminals) contrasted with the lack of correlation in the paraventricular and supraoptic nuclei (that is, the sites of the cell bodies of the same neurons). This difference in the metabolic response to functional activity between the two regions of these neurons can be explained by the differences in surface-to-volume ratios of these regions.
mesh_terms: D000818:Animals; D001369:Axons / Q000378:metabolism; D003847:Deoxyglucose / Q000378:metabolism; D004734:Energy Metabolism / Q000187:drug effects; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism*; D008297:Male; D009411:Nerve Endings / Q000378:metabolism; D010286:Paraventricular Hypothalamic Nucleus / Q000378:metabolism; D010643:Phenoxybenzamine / Q000494:pharmacology; D010904:Pituitary Gland, Posterior / Q000378:metabolism; D051381:Rats; D013495:Supraoptic Nucleus / Q000378:metabolism; D014868:Water Deprivation; D014882:Water-Electrolyte Balance
chemical_list: D010643:Phenoxybenzamine; D003847:Deoxyglucose