title: Diaspirins that cross-link beta chains of hemoglobin: bis(3,5-dibromosalicyl) succinate and bis(3,5-dibromosalicyl) fumarate.
abstract: Two double-headed aspirins, bis(3,5-dibromosalicyl) succinate and bis(3,5-dibromosalicyl) fumarate, have been found to be potent acylating agents of intracellular hemoglobin (A or S) in vitro. Furthermore, each of these reagents cross-links beta chains of hemoglobin, probably at the beta cleft. The modified hemoglobins show increased oxygen affinities and reduced gelation or sickling tendencies.
mesh_terms: D000215:Acylation; D001241:Aspirin / Q000031:analogs & derivatives*; D003432:Cross-Linking Reagents; D004912:Erythrocytes / Q000378:metabolism; D005650:Fumarates; D006441:Hemoglobin A; D006451:Hemoglobin, Sickle; D006454:Hemoglobins; D006801:Humans; D046911:Macromolecular Substances; D010100:Oxygen / Q000097:blood; D010108:Oxyhemoglobins; D013386:Succinates
chemical_list: D003432:Cross-Linking Reagents; D005650:Fumarates; D006451:Hemoglobin, Sickle; D006454:Hemoglobins; D046911:Macromolecular Substances; D010108:Oxyhemoglobins; D013386:Succinates; D006441:Hemoglobin A; D001241:Aspirin; D010100:Oxygen