Qualitative and quantitative changes in uterine mRNA populations in response to oestradiol treatment of rats.
The mRNA population of immature rat uteri, responding to different lengths of oestradiol-induced differentiation, have been compared by the technique of DNA hybridization with heterogeneous RNA. Over the first 4 h of hormone induction there are continuing qualitative and quantitative changes in the poly(A)-containing mRNA such that, by 4 h after oestradiol administration, the population bears little resemblance to that of the unstimulated animal. Between 2 h and 4 h after oestradiol administration, the most striking changes appear to be in sequences of intermediate abundance. The possible significance of these findings is discussed.
D000818:Animals; D001483:Base Sequence; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D007700:Kinetics; D009693:Nucleic Acid Hybridization; D011061:Poly A / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D014599:Uterus / Q000187:drug effects / Q000378:metabolism*
D012333:RNA, Messenger; D011061:Poly A; D004958:Estradiol