title: Evaluation and statistical judgement of neural responses to sinusoidal stimulation in cases with superimposed drift and noise.
abstract: Time histograms of neural responses evoked by sinuosidal stimulation often contain a slow drifting and an irregular noise which disturb Fourier analysis of these responses. Section 2 of this paper evaluates the extent to which a linear drift influences the Fourier analysis, and develops a combined Fourier and linear regression analysis for detecting and correcting for such a linear drift. Usefulness of this correcting method is demonstrated for the time histograms of actual eye movements and Purkinje cell discharges evoked by sinusoidal rotation of rabbits in the horizontal plane. In Sect. 3, the analysis of variance is adopted for estimating the probability of the random occurrence of the response curve extracted by Fourier analysis from noise. This method proved to be useful for avoiding false judgements as to whether the response curve was meaningful, particularly when the response was small relative to the contaminating noise.
mesh_terms: D000818:Animals; D004558:Electric Stimulation; D005069:Evaluation Studies as Topic; D005071:Evoked Potentials; D005133:Eye Movements; D005583:Fourier Analysis; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology*; D011689:Purkinje Cells / Q000502:physiology; D011817:Rabbits; D012044:Regression Analysis; D013223:Statistics as Topic