Perinatal exposure to cannabinoids alters male reproductive function in mice.
Oral administration of delta 9-tetrahydrocannabinol or cannabinol to female mice late in pregnancy and during early lactation alters body weight regulation and pituitary-gonadal function and suppresses adult copulatory activity in their male offspring. These findings suggest that both psychoactive and nonpsychoactive constituents of marihuana can affect the development of male reproductive functions in mice.
D000818:Animals; D000831:Animals, Newborn; D001835:Body Weight / Q000187:drug effects; D002186:Cannabinoids / Q000494:pharmacology*; D002187:Cannabinol / Q000494:pharmacology*; D003307:Copulation / Q000187:drug effects; D013759:Dronabinol / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D010907:Pituitary Hormones / Q000097:blood; D012733:Sex Differentiation / Q000187:drug effects*; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D012741:Sexual Maturation / Q000187:drug effects; D013737:Testis / Q000033:anatomy & histology; D013739:Testosterone / Q000097:blood
D002186:Cannabinoids; D010907:Pituitary Hormones; D013739:Testosterone; D013759:Dronabinol; D002187:Cannabinol