title: Ischaemic heart disease-an hypothesis to integrate the role of insulin, fibre and sucrose.
abstract: The theory that a high dietary cholesterol and saturated fat intake has an aetiological role in coronary artery disease is inadequate. So are those theories based upon insulin, upon refined carbohydrate and upon dietary sucrose. An alternate hypothesis is presented. Central to it is prolonged hyperinsulin-aemia. This, acting synergistically with the changes in lipide metabolism secondary to the effects of dietary fibre and sucrose, is crucial to atherogenesis. There is abundant evidence for an association of insulin and vascular changes, both in vitro and in epidemiological studies. Laboratory and epidemiological evidence also exists for an effect of fibre and soluble carbohydrate on cholesterol synthesis and excretion, both as itself and as bile acid. A scheme is presented to demonstrate these complex inter-relationships and their role in vascular diseases.
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002482:Cellulose / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D002791:Cholesterol, Dietary / Q000378:metabolism*; D003327:Coronary Disease / Q000209:etiology*; D004043:Dietary Fiber / Q000378:metabolism*; D004764:Enterohepatic Circulation; D006801:Humans; D007328:Insulin / Q000097:blood / Q000502:physiology*; D011817:Rabbits; D051381:Rats; D013395:Sucrose / Q000378:metabolism*
chemical_list: D001786:Blood Glucose; D002791:Cholesterol, Dietary; D004043:Dietary Fiber; D007328:Insulin; D013395:Sucrose; D002482:Cellulose; D002784:Cholesterol