Absorption kinetics of subcutaneously injected insulin. Evidence for degradation at the injection site.
The absorption of subcutaneously injected insulin was examined by injecting semisynthetic [3H] insulin in anaesthetized pigs and subsequently analysing the tissue excised from the injection site. Contrary to previously accepted views, a significant proportion of insulin was degraded at the injection site. The disappearance of intact [3H] insulin from the injection site followed a monoexponential function with a half-time of 59 min.
D000042:Absorption; D000818:Animals; D007279:Injections, Subcutaneous; D007328:Insulin / Q000008:administration & dosage / Q000378:metabolism*; D007700:Kinetics; D013552:Swine; D014316:Tritium
D007328:Insulin; D014316:Tritium