title: Lyon phenomenon in ouabain-treated erythrocytes of Duchenne muscular dystrophy carriers as revealed by cell electrophoresis.
abstract: Using the cell-electrophoretic method, 0.1 mM ouabain/l Eagle MEM medium caused a moderate decrease in electrophoretic migration time (EMT) of erythrocytes in 19 out of 23 DMD-affected patients. In 8 out of 10 healthy boys, 0.1 mM ouabain induced an increase in erythrocyte EMT. Under the influence of 0.1 mM ouabain, the erythrocytes clearly showed a bimodal distribution of EMT in 9 out of 13 definite carriers and in 8 out of 17 possible carriers. In DMD patients, and in 10 healthy boys and 10 healthy women, no bimodal distribution of EMT was observed.
mesh_terms: D002465:Cell Movement / Q000187:drug effects; D002478:Cells, Cultured; D004586:Electrophoresis; D004912:Erythrocytes / Q000187:drug effects*; D006580:Genetic Carrier Screening; D006801:Humans; D009136:Muscular Dystrophies / Q000097:blood* / Q000235:genetics; D010042:Ouabain / Q000494:pharmacology*
chemical_list: D010042:Ouabain