title: The effects of ketamine on the canine coronary circulation.
abstract: Systemic and coronary haemodynamic measurements have been made in six healthy greyhounds anaesthetized with trichloroethylene. The administration of ketamine in bolus doses of 5 mg/kg, 10 mg/kg and 5 mg/kg followed by an infusion 0.1 mg/kg/min was found to be accompanied by a decrease in arterial pressure and an increase in cardiac output produced by an increase (84%) in stroke volume. Coronary blood flow increased greatly as did myocardial oxygen consumption and there was no change in myocardial oxygen extraction.
mesh_terms: D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects*; D004285:Dogs; D006321:Heart / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D007649:Ketamine / Q000494:pharmacology*; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects
chemical_list: D007649:Ketamine