[Acetylation and urinary excretion of norsulfazole in gastrointestinal disease patients of different age groups].
The amount of free and acetylated norsulfazol in the urine of patients with gastrointestinal diseases was analysed 3 hours after peroral administration of the drug (20 mg/kg). The acetylation rate of norsulfazol in patients of 21--30 years of age was significantly lower than that in heathy subjects of the same age. In groups of 31--40, 41--50 and 51--60 years of age the acetylation rate was 47, 42 and 43%, respectively. In patients with chronic cholecystitis excretion with urine of free norsulfazol was 2-fold as increased whereas in chronic gastritis there was a 2.7-fold increase as compared to controls. The acetylation rate of norsulfazole was 1.6, 1.4 and 1.5-fold reduced in duodenal ulcer, cholecystitis and gastritis, respectively.
D000107:Acetylation; D000328:Adult; D000375:Aging / Q000187:drug effects*; D005260:Female; D005609:Free Radicals; D005767:Gastrointestinal Diseases / Q000652:urine*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013432:Sulfathiazoles / Q000652:urine*; D013997:Time Factors
D005609:Free Radicals; D013432:Sulfathiazoles
Atsetilirovanie i vyvedenie s mochoi norsul'fazola u bol'nykh zheludochno-kishechnymi zabolevaniiami raznykh vozrastnykh grupp.