title: Correlations between leukocidin production and virulence of two isolates of Fusobacterium necrophorum.
abstract: Leukocidin production by Fusobacterium necrophorum was suggested to be an important element in the development of intraabdominal and liver abscesses in mice. Leukocidin production by cultures of F necrophorum was demonstrated by an in vitro assay. One of two isolates of F necrophorum was demonstrated to produce leukocidin. The leukocidin-producing strain was observed to be more infective than the nonleukocidin-producing strain (as demonstrated by abscess formation following intraperitoneal injection of immune-suppressed and normal mice). The infectivity of the leukocidin-producing strain was increased by successive passage in immune-suppressed mice. A simultaneous increase in leukocidin production was also demonstrated. The nonleukocidin-producing strain could not be passed effectively and was relatively noninfective for mice.
mesh_terms: D000818:Animals; D005260:Female; D005675:Fusobacterium necrophorum / Q000302:isolation & purification / Q000378:metabolism / Q000472:pathogenicity*; D007165:Immunosuppression Therapy; D007956:Leukocidins / Q000096:biosynthesis*; D008107:Liver Diseases / Q000382:microbiology; D008297:Male; D051379:Mice; D013272:Stomach Diseases / Q000382:microbiology; D014774:Virulence
chemical_list: D007956:Leukocidins