Increased heparin binding in cystic fibrosis: a reflection of altered glycoprotein biosynthesis?
Some of the serum proteins which bind to heparin and contribute to the pH 5.57 "heparin binding capacity" of human serum are glycoproteins; those from cystic fibrosis serum were found to be 27% higher in fucose (methylpentose) content, 27% lower in sialic acid content, and 31% lower in hexose content when compared to heparin-precipitated serum glycoproteins from normal control subjects. Hexosamine content of the heparin-precipitated serum glycoproteins was the same. Results of this preliminary investigation indicate that altered carbohydrate composition in serum glycoproteins may affect significantly their heparin binding capacity.
D000293:Adolescent; D000328:Adult; D001798:Blood Proteins / Q000378:metabolism*; D002241:Carbohydrates / Q000097:blood; D003550:Cystic Fibrosis / Q000097:blood* / Q000378:metabolism; D005260:Female; D006023:Glycoproteins / Q000096:biosynthesis* / Q000097:blood; D006493:Heparin / Q000097:blood*; D006801:Humans; D008297:Male; D011485:Protein Binding
D001798:Blood Proteins; D002241:Carbohydrates; D006023:Glycoproteins; D006493:Heparin