Marked hypodiploidy in a case of acute undifferentiated leukemia.
A-29-year-old white man with acute undifferentiated leukemia had bone marrow cells with predominantly 42 chromosomes including several rearrangements. Following a brief induced "complete" remission, during which normal chromosomes were observed, bone marrow cells with 42 chromosomes but a different karyotype than before remission were found. Evaluation of that karyotype indicates not only a reduced chromosome count but also a reduced quantity of chromosome material.
D000208:Acute Disease; D000328:Adult; D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D002900:Chromosomes, Human, 1-3; D002902:Chromosomes, Human, 16-18; D002904:Chromosomes, Human, 21-22 and Y; D002905:Chromosomes, Human, 4-5; D003582:Cytogenetics; D004171:Diploidy; D006801:Humans; D007938:Leukemia / Q000235:genetics*; D008297:Male