[Guinea pig nipple as a model for the investigation of melasma (author's transl)].
The nipples of male tan guinea pigs were used to test the effects on the skin of oral contraceptive pills and drugs. The daily topically applied doses were 1/2,000 of a pill. After 3 weeks, the nipples treated with solutions of ethinyloestradiol-containing pills had grown (200-300%), the epidermis showed acanthosis (150-250%) and strong hyperpigmentation. Mestranol-containing pills as well as pure progestogen substances did not produce these effects.
D000818:Animals; D001940:Breast / Q000187:drug effects; D003276:Contraceptives, Oral / Q000494:pharmacology*; D003278:Contraceptives, Oral, Hormonal / Q000494:pharmacology*; D004997:Ethinyl Estradiol / Q000494:pharmacology; D006168:Guinea Pigs; D006965:Hyperplasia; D008297:Male; D008656:Mestranol / Q000494:pharmacology; D008954:Models, Biological; D009558:Nipples / Q000187:drug effects; D010859:Pigmentation Disorders / Q000139:chemically induced*; D011374:Progesterone / Q000494:pharmacology; D012867:Skin / Q000187:drug effects* / Q000473:pathology
D003276:Contraceptives, Oral; D003278:Contraceptives, Oral, Hormonal; D004997:Ethinyl Estradiol; D011374:Progesterone; D008656:Mestranol
La tétine du cobaye utilisée comme modèle dans l'étude du chloasma (mélasma).