QSAR in a series of muscarinic agents.
The results of a pharmacological investigation on a series of 3-substituted benzyltrimethylammonium salts possessing muscarinic activity are reported. Correlative analysis shows that the pharmacodynamic activity is a function of the hydrophobic-lipophilic and steric parameters associated with the substituents. In particular, it is revealed that a lipophilic pocket of limited size is present in the muscarinic receptor at an optimal distance from the electron--rich site with which the cationic termination interacts.
D000818:Animals; D001593:Benzyl Compounds / Q000494:pharmacology*; D007583:Jejunum / Q000187:drug effects; D010277:Parasympathomimetics / Q000494:pharmacology*; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*; D051381:Rats; D011950:Receptors, Cholinergic / Q000187:drug effects; D011976:Receptors, Muscarinic / Q000187:drug effects; D013329:Structure-Activity Relationship
D001593:Benzyl Compounds; D010277:Parasympathomimetics; D000644:Quaternary Ammonium Compounds; D011950:Receptors, Cholinergic; D011976:Receptors, Muscarinic