title: [Experiences with an oral cocaine-morphine solution (Brompton mixture) in the treatment of severe pain in patients with neoplasms].
abstract: One year's experience is reported in the treatment of terminally ill cancer patients with an oral solution of morphine and cocaine on a fixed schedule. 36 consecutive patients were treated for an average of 51 days. Excellent or good pain relief was achieved with 26 patients (72%). The initial mean daily dose of morphine was 35 mg. After 12 weeks, the dose had to be raised to an average of 52 mg per day. Some patients received up to 180 mg morphine per day. Side effects were not uncommon but were without clinical consequences in most patients. Side effects caused discontinuation of treatment in only 2 patients. Terminally ill cancer patients often derive great benefit from this treatment.
mesh_terms: D000284:Administration, Oral; D000698:Analgesia / Q000592:standards; D003042:Cocaine / Q000008:administration & dosage / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage / Q000627:therapeutic use*; D009369:Neoplasms / Q000150:complications*; D010146:Pain / Q000188:drug therapy* / Q000209:etiology
chemical_list: D004338:Drug Combinations; D009020:Morphine; D003042:Cocaine
vernacular_title: Erfahrung mit einer oralen Cocain-Morphium-Lösung ("Brompton-Mixtur") in der Behandlung schwerer Schmerzzustände bei Krebspatienten.