title: The 'singles' method for segregation analysis under incomplete ascertainment.
abstract: Li & Mantel (1968) proposed a simple new method of segregation analysis under complete ascertainment. This paper shows that, with a slight modification, the method is also valid under incomplete ascertainment. The assumptions concerning ascertainment are discussed and the method compared with the maximum likelihood method and Weinberg's proband method.
mesh_terms: D030342:Genetic Diseases, Inborn / Q000235:genetics*; D006801:Humans; D008954:Models, Biological; D010661:Phenylketonurias / Q000235:genetics; D012801:Sibling Relations; D013223:Statistics as Topic