[Autoradiographic analysis of the effect of potassium orotate on the intensity of uridine-5 3H and proline-3H incorporation into wound fibroblasts].
The intensity of uridine-53H and proline-3H incorporation into fibroblast nuclei and cytoplasm as well as into intercellular spaces was studied in wound healing of mice given potassium orotate and in the control animals. It was shown that proline-3H incorporation was more intensive than that of uridine-53H. At the same time a significant increase in RNA synthesis in fibroblasts under the action of potassium orotate, and a less pronounced rise in proline-containing protein synthesis were noted in similar conditioelationships correlate with the fibroblast ultrastructural changes in the process of their differentiation.
D000818:Animals; D001345:Autoradiography; D001692:Biological Transport; D005347:Fibroblasts / Q000378:metabolism; D051379:Mice; D009963:Orotic Acid / Q000494:pharmacology*; D011392:Proline / Q000378:metabolism*; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis; D014316:Tritium; D014529:Uridine / Q000378:metabolism*; D014951:Wounds, Stab / Q000378:metabolism*
D014316:Tritium; D009963:Orotic Acid; D012313:RNA; D011392:Proline; D014529:Uridine
Avtoradiograficheskiĭ analiz vliianiia orotata kaliia na intensivnost' vkliucheniia uridina-5 3H i prolina-3H v fibroblasty ran.