DNA synthesis in the pituitary gland of the rat: effect of sulpiride and clomiphene.
Sulpiride administration to rats releases prolactin and increases DNA replication in the anterior pituitary gland. Clomiphene prevents the stimulation of DNA synthesis produced by sulpiride, but does not affect prolactin release from the gland. These findings suggest that the intracellular prolactin content of the anterior pituitary gland plays a role in the regulation of DNA synthesis through a mechanism mediated by oestrogens.
D000818:Animals; D002996:Clomiphene / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis*; D004261:DNA Replication / Q000187:drug effects; D005260:Female; D008297:Male; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D013469:Sulpiride / Q000494:pharmacology*; D013936:Thymidine / Q000378:metabolism
D002996:Clomiphene; D013469:Sulpiride; D004247:DNA; D013936:Thymidine