title: Significance of the quantification and demonstration of hyaluronic acid in tissue specimens for the diagnosis of pleural mesothelioma.
abstract: Hyaluronic acid in pleural tissues from patients with mesothelioma, carcinoma, and asbestosis of the lung was quantified by using specific glycosaminoglycan-degrading enzymes. In all cases of pleural mesothelioma, the quantity of hyaluronic acid in mg/g of dry tissue was at least 0.10 mg, whereas carcinomatous pleural tissue and pleura in asbestosis contained 0.02 to 0.03 mg/g of dry tissue.
mesh_terms: D001195:Asbestosis / Q000175:diagnosis; D002277:Carcinoma / Q000175:diagnosis; D003937:Diagnosis, Differential; D006801:Humans; D006820:Hyaluronic Acid / Q000032:analysis*; D008654:Mesothelioma / Q000175:diagnosis*; D010994:Pleura / Q000032:analysis; D010997:Pleural Neoplasms / Q000175:diagnosis*
chemical_list: D006820:Hyaluronic Acid