Why do patients with respiratory muscle paralysis require artificial hyperventilation?
The primary reason for the need of hyperventilation in patients with respiratory paralysis is the insufficiency of the inhibitory Hering-Breuer reflex. The artificial distension of the lungs with normal tidal volume cannot inhibit the respiratory centre in contrast to the normal state.
D000818:Animals; D002415:Cats; D003964:Diaphragm / Q000187:drug effects / Q000502:physiology*; D006985:Hyperventilation / Q000503:physiopathology*; D010791:Phrenic Nerve / Q000502:physiology*; D011661:Pulmonary Stretch Receptors / Q000502:physiology; D012119:Respiration / Q000187:drug effects; D012121:Respiration, Artificial; D014403:Tubocurarine / Q000494:pharmacology; D014628:Vagotomy
D014403:Tubocurarine