Effect of methyl substitution on the irritancy of dibenz[b,f]1,4-oxazepine(CR).
The irritant properties of 3 methylated derivatives of dibenz[b,f]1,4-oxazepine (CR) have been investigated, using the guinea-pig blepharospasm test and isolated cat eye preparations, and compared with the irritancy of the unsubstituted CR molecule. In both tests, the 11-methyl derivative was non-irritant whereas 3 Me-CR and 9 Me-CR retained some irritancy although both were less potent than CR itself. The possible significance of these results are discussed in relation to earlier biochemical studies.
D000818:Animals; D001764:Blepharospasm / Q000139:chemically induced; D002415:Cats; D002924:Ciliary Body / Q000294:innervation; D003989:Dibenzoxazepines / Q000494:pharmacology*; D005123:Eye / Q000187:drug effects; D006168:Guinea Pigs; D007509:Irritants / Q000494:pharmacology; D008745:Methylation; D013329:Structure-Activity Relationship
D003989:Dibenzoxazepines; D007509:Irritants