The role of endogenous prostaglandins in the renal vascular response to clonidine.
The effect of clonidine has been studied in the isolated perfused rabbit kidney. The drug produced a dose-dependent increase in perfusion pressure and in urine flow both of which could be blocked by phentolamine. Addition of acetylsalicylic acid to the medium caused an increase in perfusion pressure and a decrease in urine volume induced by clonidine. Further addition of prostaglandin E2 to the medium prevented the changes induced by acetylsalicylic acid. These results were taken as evidence that clonidine can increase the biosynthesis of prostaglandins which could act as a modulator system for the effects of the drug in the kidney.
D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D003000:Clonidine / Q000494:pharmacology*; D004357:Drug Synergism; D005260:Female; D007668:Kidney / Q000098:blood supply*; D008297:Male; D010477:Perfusion; D011453:Prostaglandins / Q000502:physiology*; D011817:Rabbits; D012039:Regional Blood Flow / Q000187:drug effects
D011453:Prostaglandins; D003000:Clonidine; D001241:Aspirin