Effects of low doses of ochratoxin A after intratesticular injection in the rat.
The toxic effect of various doses of ochratoxin A on the rat testis was investigated after a single intratesticular injection. At time of sacrifice (day 10) degenerating changes occur in the testicular tissues: seminiferous tubules dilatation, cytolysis of the seminiferous epithelium, hyperplasia of the interstitial tissue, vascular thrombosis. The relations between the blood supply disturbances and the observed lesions are discussed.
D000818:Animals; D008297:Male; D009336:Necrosis; D009793:Ochratoxins / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D013091:Spermatogenesis / Q000187:drug effects; D013737:Testis / Q000187:drug effects / Q000473:pathology / Q000502:physiology*
D009793:Ochratoxins