Repreoducibility of a method for a graded stenosis in tubes and vessels of small calibres. An in vitro and in vivo experiment.
The reproducibility of a previously described method for graded stenosis has been tested in a model experiment and by repeated stenosis of the portal vein in rats. In the model experiment, the method was tested in terms of flow variations; in the animal experiment, in terms of prestenotic pressure variations. In the model experiment, the coefficient of variation in repeated stenosis was less than 3%. In the animal experiment, repeated stenosis constantly produced the same high level of pressure. The present method is discussed in relation to a theoretical optimal standard and found to be satisfactory.
D000818:Animals; D003097:Collateral Circulation; D003250:Constriction; D004195:Disease Models, Animal; D006339:Heart Rate; D006975:Hypertension, Portal / Q000209:etiology*; D008297:Male; D008722:Methods; D011169:Portal Vein; D051381:Rats; D012119:Respiration; D014690:Venous Pressure