title: Depressed jejunal secretion of water and ions in response to prostaglandin E1 in adult celiac disease.
abstract: In order to test in man the concept that intestinal fluid secretion originates from the crypts of Lieberkühn, we assessed the jejunal secretory effect of intraluminal prostaglandin E1 (PGE1) (0.9 microgram/kg/min) in untreated adult celiac disease (ACD, N = 7), treated ACD (N = 4) and normal subjects using the intestinal perfusion technique. In untreated ACD (1) water and solutes were malabsorbed (or secreted) in the basal period; (2) fluid and ion secretion seen during PGE1 infusion and net secretory effect of PGE1 (difference in transport between basal and PGE1 periods) were reduced (P less than 0.01); (3) the effects of PGE1 inhibition of sodium insorption, and stimulation of sodium exsorption, were decreased and abolished, respectively. In treated patients PGE1-induced secretion returned towards normal values. Our finding of a depressed secretory response to PGE1 in the face of marked crypt hypertrophy do not support the concept that crypt cells are the major site of intestinal fluid secretion.
mesh_terms: D000328:Adult; D002446:Celiac Disease / Q000178:diet therapy / Q000378:metabolism*; D004573:Electrolytes / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007419:Intestinal Secretions / Q000378:metabolism*; D007583:Jejunum / Q000187:drug effects* / Q000378:metabolism; D011458:Prostaglandins E / Q000494:pharmacology*; D012964:Sodium / Q000378:metabolism; D014867:Water / Q000378:metabolism*
chemical_list: D004573:Electrolytes; D011458:Prostaglandins E; D014867:Water; D012964:Sodium; D005947:Glucose