Promotional effect of sodium barbiturate on intestinal tumors induced in rats by dimethylhydrazine.
Noninbred Sprague-Dawley rats were administered 1,2-dimethylhydrazine hydrochloride (DMH) by gavage or methylazoxymethanol acetate by sc inoculation. Thereafter, one group was given water to which 0.1% sodium barbiturate was added, and the other was given drug-free water. They were examined 20 weeks after onset of the experiments. A direct relationship was noted between dosage of DMH and numbers of intestinal tumors induced in the rats. The rats provided with sodium barbiturate-supplemented water developed more intestinal tumors than did those that drank drug-free water.
D000818:Animals; D001463:Barbiturates / Q000633:toxicity*; D003043:Cocarcinogenesis; D004127:Dimethylhydrazines; D007414:Intestinal Neoplasms / Q000139:chemically induced*; D008099:Liver / Q000187:drug effects; D008297:Male; D008746:Methylazoxymethanol Acetate / Q000633:toxicity; D008763:Methylhydrazines; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009929:Organ Size / Q000187:drug effects; D051381:Rats
D001463:Barbiturates; D004127:Dimethylhydrazines; D008763:Methylhydrazines; D008746:Methylazoxymethanol Acetate