[Effect of the nucleic factor on lymphocyte cytotoxicity].
Under study was the influence of the nucleic factor, isolated from Ehrlich tumor ascitic fluid, on cytotoxicity of in vitro lymphocytes of CC57Br mice immunized by L-cells. In a dose of 5--10 mkm/ml this factor was shown to suppress cytotoxicity of splenic cells as well as that of lymph nodes cells of previously immunized mice. Cellular DNA of non-lineal SHR mice, hepatic RNA of normal mice C3Ha (their genotype being similar to L-cells), of non-lineal SHR mice and syngeneic CC75Br in the same concentration failed to produce such effect.
D000818:Animals; D001202:Ascitic Fluid / Q000276:immunology; D002286:Carcinoma, Ehrlich Tumor / Q000276:immunology; D003602:Cytotoxicity, Immunologic / Q000187:drug effects*; D004273:DNA, Neoplasm / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D007114:Immunization; D066298:In Vitro Techniques; D007739:L Cells / Q000276:immunology; D008099:Liver / Q000276:immunology; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D012334:RNA, Neoplasm / Q000276:immunology*
D004273:DNA, Neoplasm; D012334:RNA, Neoplasm
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