[Effect of digoxin on central hemodynamics in myocardial infarct].
The effect of digoxin on the cardiac index and diastolic pressure in the pulmonary artery was studied in 17 patients with acute myocardial infarction on the 1st-3rd day of the disease by the method of thermodilution. Twelve of these patients had clinical manifestations of congestive circulatory insufficiency. Digoxin was infused intravenously in a dose of 0.5 mg. Its infusion led to reduction of diastolic pressure in the pulmonary artery from 19.0 to 16.7 mm Hg and rise of cardiac index from 2.26 to 2.4 1/min/m2 (statistically untrustworhty difference). In all cases digoxin concentration in blood serum examined by the radioimmune method was therapeutical (1.64 ng/ml, on the average). The positive hemodynamic effect of digoxin infused in a dose producing its therapeutic concentration in blood is negligible.
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects*; D002302:Cardiac Output / Q000187:drug effects*; D004077:Digoxin / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology; D011652:Pulmonary Circulation / Q000187:drug effects*; D013318:Stroke Volume / Q000187:drug effects*; D013599:Systole / Q000187:drug effects
D004077:Digoxin
Vliianie digoksina na tsentral'nuiu gemodinamiku bol'nykh ostrym infarktom miokarda.