The aortic content of glycosaminoglycans and hydroxyproline in experimental uraemia.
The effect of experimental renal failure in rats on the various glycosaminoglycan fractions and on the hydroxyproline content of the aorta was studied with special reference to the influence of parathyroidectomy. Renal failure increased those fractions which are known to contain chondroitin sulphate and dermatan sulphate. Parathyroidectomy did not modify these changes. Parathyroidectomy in rats with intact renal function produced an increase of the same fractions. It is concluded that accumulation of sulphated glycosaminoglycans is an early event in the development of uraemic arterial disease. The significance of such accumulation for subsequent development of arterial calcification is discussed. The available data do not permit evaluation of the significance of secondary hyperparathyroidism in the genesis of the observed changes of the glycosaminoglycans.
D000818:Animals; D001011:Aorta / Q000378:metabolism* / Q000473:pathology; D002118:Calcium / Q000097:blood; D003404:Creatinine / Q000097:blood; D006025:Glycosaminoglycans / Q000378:metabolism*; D006909:Hydroxyproline / Q000378:metabolism*; D008297:Male; D010280:Parathyroid Glands / Q000502:physiology* / Q000601:surgery; D010710:Phosphates / Q000097:blood; D051381:Rats; D014511:Uremia / Q000097:blood / Q000378:metabolism* / Q000473:pathology
D006025:Glycosaminoglycans; D010710:Phosphates; D003404:Creatinine; D006909:Hydroxyproline; D002118:Calcium