Inhibition of alpha-chymotrypsin by 2-halogeno-ethanols; comparisons with 2-methyl-ethanols and urea.
2-Halogeno- and 2-methyl-ethanols inhibit alpha-chymotrypsin in the order of their substituted groups: [1] tri- greater than di- greater than mono-, [2] Br- greater than Cl- greater than CH3- greater than F-. The inhibition by the halogeno-ethanols is mediated differently from that by the methyl-ethanols, ethanol, and urea.
D000818:Animals; D002417:Cattle; D002918:Chymotrypsin / Q000037:antagonists & inhibitors*; D000431:Ethanol / Q000031:analogs & derivatives*; D007700:Kinetics; D010179:Pancreas / Q000201:enzymology; D013329:Structure-Activity Relationship; D014508:Urea / Q000494:pharmacology*
D000431:Ethanol; D014508:Urea; D002918:Chymotrypsin