Applications of perfluorinated compounds as contrast agents in computed tomography.
Perfluorohexylbromide, a nonionic and biologically inert radiodense compound, was evaluated as a potential contrast agent. Pulmonary and gastrointestinal administration of the neat liquid form was tested in dogs in conjunction with computed tomographic body scans. Contrast enhancement was demonstrable in one organ, the spleen, within 6 hr of gastrointestinal administration of perfluorohexylbromide.
D000818:Animals; D001965:Bromides / Q000378:metabolism; D003287:Contrast Media / Q000008:administration & dosage / Q000378:metabolism; D004285:Dogs; D005466:Fluorocarbons / Q000008:administration & dosage / Q000378:metabolism; D011856:Radiographic Image Enhancement; D014057:Tomography, X-Ray Computed; D006842:Hydrocarbons, Brominated
D001965:Bromides; D003287:Contrast Media; D005466:Fluorocarbons; C003071:perfluorohexylbromide; D006842:Hydrocarbons, Brominated