[Synthesis of the human proinsulin sequence 71-86, III: Synthesis via the fragments 71-78 and 79-86 (author's transl)].
The synthesis of the sequence 71-86 (XIII) of human proinsulin (sequence 6-21 of human insulin-A-chain) via the fragments 71-78 (XIy1,3) and 79-86 (XII) is described. The good solubility of the protected peptide derivatives belonging to the sequences 75-78 (IXx1,2), 79-86 (X), and 71-78 (XIy1,2), and of the fragment 71-86 (XIII) itself in organic solvents allows a quick and efficient purification of these derivatives by liquid chromatography on silica-gel columns.
D000595:Amino Acid Sequence; D006801:Humans; D007202:Indicators and Reagents; D008722:Methods; D009842:Oligopeptides / Q000138:chemical synthesis*; D011384:Proinsulin / Q000138:chemical synthesis*
D007202:Indicators and Reagents; D009842:Oligopeptides; D011384:Proinsulin
Synthese der Sequenz 71-86 des Humanproinsulins, III. Synthese über die Fragmente 71-78 und 79-86.