Topical 5-fluorouracil in the treatment of intraepithelial neoplasia of the vagina.
Twelve patients with vaginal intraepithelial neoplasia received topical therapy with 5% 5-fluorouracil cream. Six patients had carcinoma in situ, 5 had moderate dysplasia, and 1 had mild dysplasia. Five patients responded to 1 treatment course. Six patients required 2, and 1 patient required 3 courses of therapy to respond. Three patients developed recurrent vaginal intraepithelial neoplasia 11-16 months after therapy and were retreated with topical 5-fluorouracil. Vaginal irritation occurred in all patients but was limited to the duration of the treatment course.
D000287:Administration, Topical; D002278:Carcinoma in Situ / Q000188:drug therapy; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy; D014625:Vaginal Neoplasms / Q000188:drug therapy*
D005472:Fluorouracil