Cimetidine in the prevention of gastric ulcer relapse.
Twenty-five patients with healed gastric ulcers completed an 11-month double-blind controlled trial comparing cimetidine 1 g daily with placebo in the prevention of ulcer relapse. Ulcers recurred in 14 patients, 12 on placebo, 2 on cimetidine. In 11 patients, 9 on cimetidine, 2 on placebo, the ulcers remained healed at the end of the trial (P less than 0.002). Cimetidine 1 g daily significantly reduces the relapse rate in gastric ulceration.
D000368:Aged; D002927:Cimetidine / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D005069:Evaluation Studies as Topic; D006146:Guanidines / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D011897:Random Allocation; D012008:Recurrence; D013276:Stomach Ulcer / Q000517:prevention & control*
D006146:Guanidines; D002927:Cimetidine