Guanabenz degradation products and stability assay.
Guanabenz, [(2,6-dichlorobenzylidene)amino]guanidine, acetate was shown to be the E-isomer. It decomposed to form the Z-isomer, 2,6-dichlorobenzaldehyde, aminoguanidine, and 2,6-dichlorobenzaldehyde semicarbazone. A stability-indicating assay for the intact drug in the presence of all of its decomposition products by the use of UV spectroscopy is presented.
D055598:Chemical Phenomena; D002621:Chemistry; D002855:Chromatography, Thin Layer; D004355:Drug Stability; D006143:Guanabenz / Q000031:analogs & derivatives / Q000138:chemical synthesis; D006146:Guanidines / Q000031:analogs & derivatives / Q000138:chemical synthesis; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism
D006146:Guanidines; D006143:Guanabenz