title: The metabolism of saddamine in man: the fate of the benzylamine moiety of saddamine.
abstract: The metabolism of 14C-saddamine radiolabelled in the benzylamine moiety has been investigated in man after oral administration. 14C-Hippuric acid was found to be the only radiolabelled urinary metabolite, the overall amount of which was equivalent to over 95% of the dose. The time taken for elimination of 50% of the dose in the urine was approximately five hours and the corresponding value for 14C-benzylamine hydrochloride was less than one hour.
mesh_terms: D000588:Amines / Q000378:metabolism*; D000893:Anti-Inflammatory Agents / Q000378:metabolism*; D001596:Benzylamines / Q000378:metabolism*; D001711:Biotransformation; D006626:Hippurates / Q000378:metabolism; D006801:Humans; D012545:Schiff Bases / Q000378:metabolism*; D013997:Time Factors
chemical_list: D000588:Amines; D000893:Anti-Inflammatory Agents; D001596:Benzylamines; D006626:Hippurates; D012545:Schiff Bases; C019083:norletimol