[Transverse myelopathy and systemic lupus erythematosus. Report of a case and review of the literature].
A case of transverse myelopathy in systemic lupus erythematosus with subacute onset and fatal course is reported. A review of the literature is done and clinical, laboratorial, therapeutics and pathological aspects are discussed. The authors call attention to the poor results of therapy and discuss the participation of immunological factors leaving to demyelination which are, aside the classical vascular involvement, the probable mechanisms in the neurological manifestations of systemic lupus erythematosus. The authors believe that, in their case, such a demyelinative mechanism was responsible for the clinical picture, although a necroscopic examination was not allowed.
D000293:Adolescent; D003711:Demyelinating Diseases / Q000209:etiology; D003907:Dexamethasone / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006886:Hydroxychloroquine / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008180:Lupus Erythematosus, Systemic / Q000134:cerebrospinal fluid / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D009187:Myelitis / Q000209:etiology*; D009188:Myelitis, Transverse / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D011241:Prednisone / Q000009:adverse effects / Q000627:therapeutic use
D007166:Immunosuppressive Agents; D006886:Hydroxychloroquine; D003907:Dexamethasone; D011241:Prednisone
Mielopatia transversa e lupus eritematoso sistêmico. Registro de um caso e revisão da literatura.