Decrease of testosterone, cholesterol and ascorbic acid in the rat testis after administration of pineal polypeptides.
Administration of 2 ml/day/animal, of melatonin-free pineal extract to the rat for three days induced a significant decrease in the testicular tissue concentration of testosterone, cholesterol and ascorbic acid. A dose of 1 microgram melatonin/day/animal given for 3 days did not alter these biochemical elements implied in testicular steroidogenesis.
D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism*; D002784:Cholesterol / Q000378:metabolism*; D008297:Male; D008550:Melatonin; D010455:Peptides / Q000494:pharmacology*; D010870:Pineal Gland / Q000502:physiology*; D051381:Rats; D013737:Testis / Q000187:drug effects / Q000378:metabolism*; D013739:Testosterone / Q000378:metabolism*
D010455:Peptides; D013739:Testosterone; D002784:Cholesterol; D008550:Melatonin; D001205:Ascorbic Acid