title: [Pharmacokinetic study of rifampicin in the body of pregnant animals].
abstract: The study on distribution of 14C-rifampicin administered intramuscularly to pregnent animals showed that its concentrations in the blood, liver, kidneys, lungs and other organs did not practically change from those in nonpregnant animals. The concentration of 14C-rifampicin in the fetus organs was much lower than that in the organs of the adult animals. The liver and kidneys of the pregnant animals, as well as the fetus though to a less extent had a capacity for metabolism of 14C-rifampicin. The following products of biotransformation were detected: N-oxide of rifampicin, 25-deacetylrifampicin, 3-formylrifamycin SV and rifamycin SV.
mesh_terms: D000818:Animals; D001711:Biotransformation; D005260:Female; D005333:Fetus / Q000378:metabolism; D007700:Kinetics; D051379:Mice; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D012293:Rifampin / Q000378:metabolism*; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D012293:Rifampin
vernacular_title: Izuchenie farmakokinetiki rifampitsina v organizme beremennykh zhivotnykh.