title: Hageman factor activation and tight junction disruption in mice challenged with attenuated endotoxin.
abstract: Endotoxin treated with chromium chloride is less toxic to mice than the parent molecule, but can disrupt intestinal permeability barriers and has an enhanced ability to activate Hageman factor.
mesh_terms: D000818:Animals; D002857:Chromium / Q000494:pharmacology*; D004731:Endotoxins / Q000037:antagonists & inhibitors* / Q000633:toxicity; D004848:Epithelium / Q000648:ultrastructure; D005174:Factor XII / Q000378:metabolism*; D007082:Ileum / Q000187:drug effects* / Q000648:ultrastructure; D007365:Intercellular Junctions / Q000187:drug effects*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D051379:Mice; D010539:Permeability; D012485:Salmonella typhi
chemical_list: D004731:Endotoxins; D008070:Lipopolysaccharides; D002857:Chromium; D005174:Factor XII