[Relationship of the activity of cardiac cholinergic mechanisms to the state of the sympathetic innervation and its noradrenaline content in hypoxia].
Preliminary sympathectomia depletes acetylcholine (ACh) in the heart of rabbits under hypoxia. In these conditions the inhibitory action of ACh on the rat isolated heart is reduced under the noradrenaline content fall, while under increase it is potentiated. Under hypoxia noradrenaline increases concentration of potassium in the myocardium, thus stimulating ACh formation and activity. It is suggested that under deep hypoxia suppression of the sympathetic mechanisms causes functional isolation of the heart from nervous effects.
D000109:Acetylcholine / Q000502:physiology; D000818:Animals; D006321:Heart / Q000503:physiopathology*; D000860:Hypoxia / Q000503:physiopathology*; D066298:In Vitro Techniques; D008297:Male; D009638:Norepinephrine / Q000502:physiology*; D011817:Rabbits; D051381:Rats; D011950:Receptors, Cholinergic / Q000502:physiology*; D013562:Sympathectomy; D013564:Sympathetic Nervous System / Q000503:physiopathology*
D011950:Receptors, Cholinergic; D000109:Acetylcholine; D009638:Norepinephrine
Zavisimost' deiatel'nosti kholinergicheskikh mekhanizmov serdtsa ot sostoianiia simpaticheskoĭ innervatsii i soderzhaniia v nem noradrenalina pri gipoksii.