title: Familial transmission of preauricular fistula in a seven generation Indian pedigree.
abstract: Familial occurrence of fistula auris congenita (ear pits) is described in a Muslin kindred of Indian origin. The pedigree was traced through seven generations. The abnormality appeared in sixty individuals comparising equal number of males and females. No sexual dimorphism was indicated in the expression of the trait, which occurred bilaterally as a small pit just anterior to the crus at the root of the ascending helix. The abnormality was found to be inherited through an autosomal dominant gene with incomplete penetrance. The expression of the trait does not show any dosage effect.
mesh_terms: D003241:Consanguinity; D004431:Ear, External / Q000002:abnormalities*; D005260:Female; D005799:Genes, Dominant; D006801:Humans; D007194:India; D008297:Male; D010375:Pedigree; D010641:Phenotype; D012737:Sex Factors