title: In vitro estimation of the proliferative state of murine bone marrow "colony forming units in culture" (CFUc) with hydroxyurea (HU).
abstract: Exposure of CFUc to 1.0 mM of HU for two hours was at the plateau of both the dose--and time--respose curves, killing 38% of the CFUc. This is compatible with the result of the 3HTdR "suicide" method, a standard procedure for the estimation of the proportion of CFUc being in the S phase.
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D003114:Colony-Forming Units Assay; D006918:Hydroxyurea / Q000494:pharmacology*; D066298:In Vitro Techniques; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA
chemical_list: D006918:Hydroxyurea