title: High molecular weight substances with insulin immunoreactivity.
abstract: Substances which react with anti-insulin antibodies, but have a higher molecular weight than insulin are described. They have been studied by various authors in pancreatic adenomas, pancreas extracts, serum and cell-free systems. Proinsulin was the first of these products to be discovered, followed by its precursor, pre-proinsulin, and subsequently by a whole series of substances of ill-defined composition and more or less similar properties, grouped under the heading of "high molecular weight immunoreactive insulin" (HWIRI).
mesh_terms: D000236:Adenoma / Q000032:analysis; D000595:Amino Acid Sequence; D000941:Antigens; D006801:Humans; D007330:Insulin Antibodies; D008970:Molecular Weight; D010179:Pancreas / Q000032:analysis; D010190:Pancreatic Neoplasms / Q000032:analysis; D011384:Proinsulin / Q000097:blood; D011498:Protein Precursors / Q000032:analysis
chemical_list: D000941:Antigens; D007330:Insulin Antibodies; D011498:Protein Precursors; D011384:Proinsulin