title: [Protective action of remantadine during an influenza outbreak caused by virus A (H1N1) in December 1977].
abstract: The protective effect of remantadin during an influenza outbreak in December 1977 caused by A (H1N1) virus was studied. A prophylactic administration of remantadin decreased influenza and ARD incidence by 1.5-fold. A more significant decrease of the incidence (2.5-fold) was observed among the subjects given a combination of remantadin and influenza vaccine (H3N2) a few days before the outbreak, which was apparently due to the interferon-inducing capacity of the vaccine.
mesh_terms: D000218:Adamantane / Q000008:administration & dosage* / Q000031:analogs & derivatives / Q000276:immunology; D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D004196:Disease Outbreaks / Q000517:prevention & control*; D004341:Drug Evaluation; D005069:Evaluation Studies as Topic; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype; D009980:Influenza A virus / Q000187:drug effects*; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000276:immunology; D007251:Influenza, Human / Q000276:immunology / Q000517:prevention & control*; D010919:Placebos; D013997:Time Factors; D014586:USSR
chemical_list: D000914:Antibodies, Viral; D007252:Influenza Vaccines; D010919:Placebos; D000218:Adamantane
vernacular_title: Izuchenie zashchitnogo deĭstviia remantadina vo vremia vspyshki grippa, vyzvannoĭ virusom A (H1N1), v dekabre 1977 g.