Vaginal prostaglandin E2 for interruption of pregnancy and management of intrauterine death.
Vaginal suppositories containing 20 mg prostaglanding E2, administered at 2-5h intervals, are very effective in interrupting second-trimester pregnancy and in inducing labor in case of death in utero. However, side effects are common and make the treatment unpleasant to most patients. Premedication with an maintenance of a potent anti-emetic (e.g. haloperidol) and an anti-diarrheic (e.g. loperamide) considerably reduce the frequency and severity of these side effects.
D000020:Abortifacient Agents, Nonsteroidal; D000030:Abortion, Missed / Q000628:therapy; D000032:Abortion, Therapeutic; D000328:Adult; D000930:Antidiarrheals / Q000627:therapeutic use; D000932:Antiemetics / Q000627:therapeutic use; D003967:Diarrhea / Q000139:chemically induced*; D005260:Female; D005313:Fetal Death; D006801:Humans; D006828:Hydatidiform Mole / Q000628:therapy; D011247:Pregnancy; D011458:Prostaglandins E / Q000008:administration & dosage* / Q000009:adverse effects; D014839:Vomiting / Q000139:chemically induced*
D000020:Abortifacient Agents, Nonsteroidal; D000930:Antidiarrheals; D000932:Antiemetics; D011458:Prostaglandins E