Effects of chlorpromazine and estradiol benzoate on prolactin secretion in gonadectomized male and female rats.
The effects of chlorpromazine (CPZ) and estradiol benzoate (EB) on serum prolactin (PRL) levels were studied in gonadectomized male and female rats. In both sexes CPZ (25 mg/kg body weight) produced an elevation of PRL when measured 2 hr after the injection, but the elevated levels were higher in ovariectomized rats than in orchidectomized rats. These results reconfirm a sexual difference in the regulatory mechanism of PRL secretion in response to the dopamine receptor blocker. Pretreatment with 5 microgram EB 48 hr before CPZ injection abolished this sexual difference in serum PRL concentration.
D000818:Animals; D002369:Castration; D002746:Chlorpromazine / Q000494:pharmacology*; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D008297:Male; D011388:Prolactin / Q000378:metabolism*; D051381:Rats; D012737:Sex Factors
D004958:Estradiol; D011388:Prolactin; D002746:Chlorpromazine