title: Labetalol in controlled hypotension: administration of labetalol when adequate hypotension is difficult to achieve.
abstract: A study of controlled hypotension was undertaken in 50 major surgical patients using labetalol, a drug with both alpha- and beta-adrenoceptor blocking activity. The patients were such that difficulty in achieving controlled hypotension could be anticipated: the young, the anxious and those for whom halothane was contraindicated. The administration of labetalol quickly induced hypotension which was controlled easily and was rapidly antagonized.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D004334:Drug Administration Schedule; D004983:Ethanolamines / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007023:Hypotension, Controlled; D007741:Labetalol / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D004983:Ethanolamines; D007741:Labetalol