The role of serotonin in Masugi nephritis in rabbits.
In 12 rabbits with induced experimental Masugi nephritis and in 6 control rabbits the level of 5-HT in whole blood and 5-HIAA excretion in urine/24 h were studied. In all animals of the experimental group a significant increase of 5-HT and 5-HIAA was found, which was strictly correlated in time with two-phase immunological reaction occurring in Masugi nephritis. Moreover, the electorn microscope examinations showed a distinct thickening of glomerular basement membrane on the 8th day of experiment, i.e., at the time of maximum 5-HT increase in the blood, which according to the literature, can be interpreted as having been caused, if not exclusively, so at least among others, by direct action of endogenous 5-HT.
D000818:Animals; D001485:Basement Membrane / Q000648:ultrastructure; D006897:Hydroxyindoleacetic Acid / Q000652:urine*; D007678:Kidney Glomerulus / Q000648:ultrastructure; D009393:Nephritis / Q000378:metabolism*; D011817:Rabbits; D012701:Serotonin / Q000032:analysis*
D012701:Serotonin; D006897:Hydroxyindoleacetic Acid