Antidopaminergic activity of estrogens on prolactin release at the pituitary level in vivo.
Treatment of female or male rats with estradiol benzoate led to an almost complete reversal of the inhibitory effect of low doses of dopamine on prolactin secretion. These data indicate that estrogens which have previously been shown to exert a potent antidopaminergic activity on prolactin secretion in anterior pituitary cells in primary culture have similar effects in vivo.
D000818:Animals; D004298:Dopamine / Q000494:pharmacology* / Q000502:physiology; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D008297:Male; D010903:Pituitary Gland, Anterior / Q000187:drug effects / Q000378:metabolism*; D010905:Pituitary Hormone Release Inhibiting Hormones / Q000502:physiology; D011388:Prolactin / Q000037:antagonists & inhibitors / Q000378:metabolism*; D051381:Rats
D004967:Estrogens; D010905:Pituitary Hormone Release Inhibiting Hormones; D011388:Prolactin; D004298:Dopamine