[Clonogenic cell response of murine NK Ly/LL solid tumor to N-methyl-N-nitrosourea].
By the in vitro technic for obtaining clones of cells of murine solid tumor NKLy/LL it was demonstrated that clonogenic cells survival rate versus NNU dosage curve in the interval of 12.5--200.0 mg/kg is exponential and characterized by the dosage value D0 = 29.15 mg/kg. In large size tumors (15.0--17.0 g) which higher death rate of clonogenic cells was noted (the survived fraction approximately 0.5%) than in tumors weighing 1.0--7.0 g (the survived fraction--2--4%), that seems to be related to a greater sensitivity of resting tumor cells to MNU.
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D002999:Clone Cells / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D066298:In Vitro Techniques; D008770:Methylnitrosourea / Q000627:therapeutic use*; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D009607:Nitrosourea Compounds / Q000627:therapeutic use*
D009607:Nitrosourea Compounds; D008770:Methylnitrosourea
Reaktsiia klonogennykh kletok solidnoĭ opukholi NK Ly/LL mysheĭ na N-metil-N-nitrozomochevinu.