title: Differential heat sensitivity of human creatine kinase isoenzymes.
abstract: Creatine kinase isoenzymes (MM, MB and BB) were isolated from human tissue by ion-exchange chromatography. The B subunit was found to be more heat sensitive than the M subunit. BB and MB isoenzymes respond similarly to heat inactivation. Our results are in contrast with the body temperature inactivation of the brain isoenzyme reported by Lindsey and Diamond.
mesh_terms: D001921:Brain / Q000201:enzymology; D003402:Creatine Kinase / Q000302:isolation & purification*; D006358:Hot Temperature; D006801:Humans; D007527:Isoenzymes; D009206:Myocardium / Q000201:enzymology; D013997:Time Factors
chemical_list: D007527:Isoenzymes; D003402:Creatine Kinase