[The influence of highly purified hCG on the immunocompetence of human lymphocytes and DNA repair system].
PHA-stimulation of human T-lymphocytes, a parameter of cellular immunocompetence, can be suppressed by highly purified human chorionic gonadotropin (hCG) in a dose-dependent manner. This was shown spectrophotometrically and by the mitosis index. Our results are in agreement with H3-thymidine incorporation studies. We further investigated the DNA repair system in UV-light- and hCG-explsed lymphocytes. It could be shown that DNA repair-replication is disturbed by hCG. Such repair disturbances may cause reduced H3-thymidine incorporation in PHA-stimulated and hCG-treated lymphocytes. It is probably on this molecular level that hCG influences the immunocompetence of human lymphocytes.
D000906:Antibodies; D006063:Chorionic Gonadotropin / Q000276:immunology / Q000494:pharmacology*; D003078:Colchicine; D004260:DNA Repair / Q000187:drug effects*; D004306:Dose-Response Relationship, Immunologic; D006801:Humans; D037102:Lectins; D008213:Lymphocyte Activation / Q000187:drug effects*; D008938:Mitosis
D000906:Antibodies; D006063:Chorionic Gonadotropin; D037102:Lectins; D003078:Colchicine
Untersuchungen über en Einfluss von hochgereinigtem Choriongonadotropin auf die Immunkompetenz menschlicher Lymphozyten und das DNS-Reparatursystem.