title: Platelets and platelet function in patients with chronic uremia on maintenance hemodialysis.
abstract: In 20 chronic uremic patients on maintenance hemodialysis, who were not taking any medication known to affect platelet function, the following investigations were carried out: platelet count, fibrin/fibrinogen degradation products, fibrinogen and plasminogen concentration, platelet adhesiveness, clot retraction and platelet aggregation induced by ADP, ristocetin, fibrinogen, collagen and epinephrine. The only significant abnormal result was a decreased clot retraction. We consider many cases of so-called uremic bleeding to be caused by the medication taken and conclude that on well-controlled hemodialysis treatment, bleeding tendency should not be a major problem.
mesh_terms: D001778:Blood Coagulation Disorders / Q000150:complications; D001779:Blood Coagulation Factors; D001792:Blood Platelets; D006801:Humans; D010976:Platelet Count; D010979:Platelet Function Tests; D006435:Renal Dialysis; D014511:Uremia / Q000097:blood* / Q000150:complications / Q000628:therapy
chemical_list: D001779:Blood Coagulation Factors