Changes in serum proteins and in major liver constituents following carbon tetrachloride and a high-fat choline-free diet in rats.
Both carbon tetrachloride and a high-fat, low-protein choline-free diet cause hepatomegaly in rats due to an accumulation of both lipids and proteins with a concomitant increase in deoxyribonucleic acid content. CCl4 causes a decline in hepatic glycogen. Serum albumin level is decreased in CCl4-treated rats and increased in those fed the experimental diet.
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism*; D002252:Carbon Tetrachloride Poisoning / Q000378:metabolism*; D002794:Choline / Q000494:pharmacology*; D004041:Dietary Fats; D005260:Female; D008099:Liver / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D011506:Proteins / Q000378:metabolism; D051381:Rats
D001798:Blood Proteins; D004041:Dietary Fats; D011506:Proteins; D002794:Choline