Autoimmune hemolytic anemia. 2. Drug-induced type.
A variety of commonly prescribed drugs can produce a positive direct antiglobulin test, but the incidence of actual drug-induced hemolytic anemia is low. Of the four mechanisms which may be responsible, only one involves autoantibody production; the others include drug-RBC interaction of the hapten type, immune complex formation, and direct alteration of the RBC membrane.
D000368:Aged; D000744:Anemia, Hemolytic, Autoimmune / Q000139:chemically induced* / Q000276:immunology; D000917:Antibody Formation; D000936:Antigen-Antibody Complex; D001323:Autoantibodies; D002462:Cell Membrane / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects; D005260:Female; D006241:Haptens; D006801:Humans; D008750:Methyldopa / Q000009:adverse effects; D010406:Penicillins / Q000009:adverse effects; D011803:Quinine / Q000009:adverse effects
D000936:Antigen-Antibody Complex; D001323:Autoantibodies; D006241:Haptens; D010406:Penicillins; D008750:Methyldopa; D011803:Quinine