title: Reactivity to calcitonin after ovariectomy.
abstract: The hypocalcemic response to calcitonin injected in female rats disappeared after their castration. The substitution treatment with estrogens does no allow reestablishment of the hypocalcemic effect obtained in intact animals, a fact that lays stress on the role of the whole ovarian secretion in maintaining a normal response to calcitonin. The response of castrated animals to calcitonin calls attention to the conditional role of estrogens in validating the osteoprotecting effect of calcitonin.
mesh_terms: D000818:Animals; D002116:Calcitonin / Q000494:pharmacology*; D002118:Calcium / Q000097:blood*; D002369:Castration; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D006996:Hypocalcemia / Q000139:chemically induced; D051381:Rats
chemical_list: D004958:Estradiol; D002116:Calcitonin; D002118:Calcium