title: The affinity of cholesterol for phosphatidylcholine and sphingomyelin.
abstract: Erythrocyte ghosts were incubated with sonicated vesicles and the uptake of cholesterol by vesicles allowed to proceed to equilibrium. The experiments were carried out for a series of phospholipids at different temperatures. The equilibrium partition of cholesterol between ghosts and single shelled vesicles provided a measure of the relative affinities of cholesterol for the different phospholipids studied. It was found that the affinity of cholesterol for dipalmitoyl phosphatidylcholine was the same as that for N-palmitoyl sphingomyelin both at temperatures above and below the gel to liquid crystalline transition temperature of these phospholipids.
mesh_terms: D002784:Cholesterol / Q000097:blood; D004910:Erythrocyte Membrane / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008567:Membranes, Artificial; D010713:Phosphatidylcholines; D013109:Sphingomyelins; D013329:Structure-Activity Relationship
chemical_list: D008567:Membranes, Artificial; D010713:Phosphatidylcholines; D013109:Sphingomyelins; D002784:Cholesterol