Adverse effects of interferon treatment on the life span of NZB mice.
NZB mice treated with interferon from birth and for over a year, display early some characteristics of the autoimmune disease. In these animals, mortality is clearly higher than in controls. Their death occurs 3 to 6 months before that of mice injected with a "mock" preparation.
D000818:Animals; D000906:Antibodies; D001327:Autoimmune Diseases / Q000139:chemically induced* / Q000276:immunology; D005260:Female; D007372:Interferons / Q000009:adverse effects*; D008297:Male; D051379:Mice; D008814:Mice, Inbred NZB; D009026:Mortality; D010919:Placebos
D000906:Antibodies; D010919:Placebos; D007372:Interferons