Calorigenic effect of insulin in hypothermic dogs.
In dogs acutely immersed in cold water (8--13 degrees C), oxygen uptake increased approximately sevenfold and colonic temperature rapidly began to decrease. Fifteen minutes after the start of immersion a high level of hyperglycemia was found but no increase in immunoreactive plasma insulin level was observed. Under these conditions exogenous insulin (0.3 U.kg-1) induced a further increase in oxygen uptake and in shivering intensity whereas a decrease in the fall of colonic temperature was observed. It can be concluded that insulin may have a calorigenic effect and improve the resistance to cold of dogs exposed to an acute cold stress.
D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D003080:Cold Temperature; D004285:Dogs; D007035:Hypothermia / Q000097:blood; D007101:Immersion; D007328:Insulin / Q000097:blood / Q000494:pharmacology*
D007328:Insulin