title: Effects of chlorpromazine and estradiol benzoate on prolactin secretion in gonadectomized male and female rats.
abstract: The effects of chlorpromazine (CPZ) and estradiol benzoate (EB) on serum prolactin (PRL) levels were studied in gonadectomized male and female rats. In both sexes CPZ (25 mg/kg body weight) produced an elevation of PRL when measured 2 hr after the injection, but the elevated levels were higher in ovariectomized rats than in orchidectomized rats. These results reconfirm a sexual difference in the regulatory mechanism of PRL secretion in response to the dopamine receptor blocker. Pretreatment with 5 microgram EB 48 hr before CPZ injection abolished this sexual difference in serum PRL concentration.
mesh_terms: D000818:Animals; D002369:Castration; D002746:Chlorpromazine / Q000494:pharmacology*; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D008297:Male; D011388:Prolactin / Q000378:metabolism*; D051381:Rats; D012737:Sex Factors
chemical_list: D004958:Estradiol; D011388:Prolactin; D002746:Chlorpromazine