Effects of cerebral intraventricular magnesium injections and a low magnesium diet on nonspecific excitability level, audiogenic seizure susceptibility and serotonin.
Cerebral intraventricular injections of 17 and 50 microgram magnesium in artificial cerebrospinal fluid progressively depressed the Non-specific Excitability Level of permanently cannulated 150--200 g rats fed a low magnesium diet for 21 days. Compared with control diet, a low Mg diet caused an increase in brain serotonin. Weanling rats fed a low Mg diet for 2 weeks, then injected with 25 microgram Mg via acute cannulations, displayed reduced audiogenic seizure susceptibility compared with sham-injected controls.
D000161:Acoustic Stimulation; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D007276:Injections, Intraventricular; D008274:Magnesium / Q000008:administration & dosage / Q000494:pharmacology*; D008275:Magnesium Deficiency / Q000378:metabolism / Q000523:psychology*; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D012640:Seizures / Q000503:physiopathology*; D012701:Serotonin / Q000378:metabolism*
D012701:Serotonin; D008274:Magnesium; D004298:Dopamine; D009638:Norepinephrine