In vitro metabolism of 4-androstene-3,17-dione and testosterone by rat submaxillary gland.
Tritiated 4-androstene-3,17-dione and testosterone were incubated with submaxillary gland homogenates of male and female rats. The metabolism was predominately reductive. In 15 and 180 min incubations submaxillary tissue converted 4-androstene-3,17-dione chiefly to androsterone. Less testosterone, 17 beta-hydroxy-5 alpha-androstan-3-one, 5 alpha-androstane-3,17-dione, 5 alpha-androstane-3 alpha, 17 beta-diol, and 4-androstene-3 alpha, 17 beta-diol were also identified. Testosterone was converted to the same products plus 4-androstene-3,17-dione. 5 alpha-Androstane-3 alpha, 17 beta-diol was the major testosterone metabolite. Qualitatively the metabolism by male and female submaxillary gland was similar.
D015113:Androstane-3,17-diol / Q000378:metabolism; D000734:Androstenediols / Q000378:metabolism; D000735:Androstenedione / Q000378:metabolism*; D000738:Androsterone / Q000378:metabolism; D000818:Animals; D005260:Female; D008297:Male; D051381:Rats; D013363:Submandibular Gland / Q000378:metabolism*; D013739:Testosterone / Q000378:metabolism*
D000734:Androstenediols; D015113:Androstane-3,17-diol; D013739:Testosterone; D000735:Androstenedione; D000738:Androsterone