Pharmacokinetics of norethindrone in Indian Women.
Pharmacokinetics of norethindrone (NET) was evaluated in eleven women belonging to a low socio-economic group and in five womem belonging to the high socio-economic group after the administration of an oral dose of 0.35 mg NET minipill on an empty stomach. Blood samples were collected at different intervals of time over a period of 24 hours. Plasma NET was estimated by radioimmunoassay. In all women, peak levels of NET occurred within 1-2 hours and a semi-log plot of plasma NET levels showed a biexponential decline. The half-life of plasma NET clearance was relatively shorter in women of low socio-economic group with poor nutritional status as indicated by anthropometric indices, as compared to that in well nourished women of high socio-economic group. There was a significant positive correlation between weight/(height) 2x 100 index on the one hand and t1/2 (beta) on the other in all the women studied, thereby suggesting a role for nutritional status in the metabolic handling of NET.
D000042:Absorption; D000328:Adult; D000886:Anthropometry; D005260:Female; D006801:Humans; D007194:India; D007700:Kinetics; D009640:Norethindrone / Q000097:blood / Q000378:metabolism*; D011863:Radioimmunoassay; D012959:Socioeconomic Factors; D013997:Time Factors
D009640:Norethindrone