title: Breeding studies reveal segregation of a canine Robertsonian translocation along Mendelian proportions.
abstract: Six matings of golden retriever-type mongrel dogs with a 13/23 Robertsonian translocation were studied. Three matings between normal dogs and dogs heterozygous for the translocation produced 12 normals and 11 heterozygotes. In three matings between heterozygotes, the distribution of normal, heterozygous, and homozygous proteny was Mendelian (8:12:5). No gross phenotypic anomalies were observed with the exception of congenital inguinal hernia in two female homozygotes. Nondisjunction in the form of trisomic or monosomic individuals for either autosome 13 or 23 was not observed.
mesh_terms: D000818:Animals; D001947:Breeding; D002871:Chromosome Banding; D003433:Crosses, Genetic; D004285:Dogs / Q000235:genetics*; D005260:Female; D006580:Genetic Carrier Screening; D006579:Heterozygote; D006720:Homozygote; D007621:Karyotyping; D008297:Male; D010375:Pedigree; D014178:Translocation, Genetic