[Properties of viruses isolated from human fibroblasts culture treated by paraganglioma culture filtrate].
In the human fibroblasts culture, transformed by the material from malignant paraganglioma culture, there was found the RNA- and DNA containing virus synthesis. The RNA-containing virus with a buoyant density of 1.16--1.18 g/ml shows no hemagglutinating activity, it fails to infect newborn Syrian hamsters, and produces no transformation-destruction changes in mammalian tissue culture. The DNA-containing virus with a buoyant density of 1.24--1.28 g/ml would agglutinate the guinea-pig and group 0 human erythrocytes, produces lesions in newborn Syrian hamsters, and cytodestructive changes in the culture of rat and mice embryonal cells and in cells of a transplantable line Vero. In terms of its properties it may be referred to human viruses of the Papova group. A combined action of DNA- and RNA-containing viruses produces a transformation effect on embryonal hamster cells and the cells of a transplantable line Vero.
D000818:Animals; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D006224:Cricetinae; D004267:DNA Viruses / Q000302:isolation & purification; D005347:Fibroblasts / Q000382:microbiology*; D006801:Humans; D008647:Mesocricetus; D051379:Mice; D027383:Papillomaviridae / Q000302:isolation & purification*; D010235:Paraganglioma / Q000382:microbiology*; D027382:Polyomaviridae; D012328:RNA Viruses / Q000302:isolation & purification; D051381:Rats
Svoĭstva virusov, vydelennykh iz kul'tury fibroblastov cheloveka, obrabotannoĭ fil'tratom kul'tury paragangliomy.