Effect of sodium nitrite on the alpha-chlorohydrin-induced lesion of the testis--epididymis complexin the rat.
Administration of vasodilator, sodium nitrite (20 mg/kg body weight), 30 min before alpha-chlorohydrin treatment (90 mg/kg body weight) prevented the chlorohydrin-induced lesion in rat testis--epididymis complex. However, administration of vasodilator 90 min after alpha-chlorohydrin treatment did not prevent the chlorohydrin-induced lesion in the testis--epididymis complex. These observations suggest that the testicular vasculature is involved in drug action.
D000818:Animals; D002728:Chlorohydrins / Q000494:pharmacology*; D004822:Epididymis / Q000187:drug effects*; D008297:Male; D009573:Nitrites / Q000494:pharmacology*; D051381:Rats; D012977:Sodium Nitrite / Q000494:pharmacology*; D013737:Testis / Q000187:drug effects*; D000517:alpha-Chlorohydrin / Q000494:pharmacology*
D002728:Chlorohydrins; D009573:Nitrites; D000517:alpha-Chlorohydrin; D012977:Sodium Nitrite