Passive--active immunization in a neonate treated with repeated doses of high-titred hepatitis B immune globulin.
A newborn infant, born to a HBsAg-positive drug addict with HBeAg and DNA-polymerase activity in serum, was treated with repeated very high doses of hepatitis B immune globulin (HBIg). The mother turned HBsAg-negative about 8 months after deliver and the HBIg prophylaxis was then discontinued. A check-up of the infant about a year later revealed normal liver function tests but significantly increased levels of antibodies against HBcAg and HBsAg indicating a post subclinical hepatitis B infection, apparently without harm to the infant.
D000914:Antibodies, Viral / Q000032:analysis; D005260:Female; D006509:Hepatitis B / Q000276:immunology / Q000517:prevention & control* / Q000635:transmission; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006801:Humans; D007114:Immunization; D007136:Immunoglobulins / Q000008:administration & dosage / Q000627:therapeutic use*; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000276:immunology / Q000517:prevention & control* / Q000635:transmission; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D019966:Substance-Related Disorders
D000914:Antibodies, Viral; D006514:Hepatitis B Surface Antigens; D007136:Immunoglobulins