Selected sulfhydryl inhibitors capable of inducing immunity against cancer in mice.
Selected sulfhydryl inhibitors show greater toxicity to some animal and human cancers than to normal cells, both clinically and in drug sensitivity tests. Such selected SH inhibitors can induce immunity against cancer in mice, unlike other commonly used antitumor agents. Scanning electron micrographs of the surface of Ehrlich ascites cancer cells treated with the sulfhydryl inhibitors show blunting to absence of microvilli and modification of the surface texture of the cancer cells.
D000818:Animals; D001152:Arsenicals / Q000494:pharmacology; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000276:immunology / Q000648:ultrastructure; D007109:Immunity / Q000187:drug effects*; D007461:Iodoacetates / Q000494:pharmacology; D051379:Mice; D008855:Microscopy, Electron, Scanning; D008871:Microvilli / Q000187:drug effects; D009941:Organomercury Compounds / Q000494:pharmacology; D013439:Sulfhydryl Reagents / Q000494:pharmacology*
D001152:Arsenicals; D007461:Iodoacetates; D009941:Organomercury Compounds; D013439:Sulfhydryl Reagents