A temporal profile of changes in myocardial manganese after isoprenaline induced cardiac necrosis in albino rats.
Myocardial-necrosis was produced in two groups of albino rats by subcutaneous injection of isoprenaline in doses of 85 mg/kg and 42.5 mg/kg. The necrosis was confirmed by ECG changes, increased serum activities of AspAT, AlAT, GPT and LDH, and by histological examination. Myocardial manganese after isoprenaline administration was estimated over a period of 5 days. The decrease in myocardial manganese was proportional to the extent of cardiac damage. The possible mechanisms and the importance of these changes are discussed.
D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D004195:Disease Models, Animal; D004562:Electrocardiography; D007545:Isoproterenol; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D008345:Manganese / Q000378:metabolism*; D009203:Myocardial Infarction / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D009336:Necrosis / Q000139:chemically induced; D051381:Rats
D008345:Manganese; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D007545:Isoproterenol