Malaria and erythrocyte glucose-6-phosphate dehydrogenase variants in West Africa.
In a clinical study, 702 Nigerian children aged 1-6 years were examined for malaria. Comparison of morbidity rates and parasitemia of patients with different glucose-6-phosphate dehydrogenase (G6PD) status provided evidence that in heterozygous females the gene for G6PD deficiency (GdA-/GdB) confers an advantage against malaria.
D002648:Child; D002675:Child, Preschool; D004912:Erythrocytes / Q000201:enzymology / Q000469:parasitology; D005260:Female; D005796:Genes; D014644:Genetic Variation; D005838:Genotype; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D007223:Infant; D008288:Malaria / Q000201:enzymology / Q000235:genetics*; D008297:Male; D009549:Nigeria; D010961:Plasmodium