Bacterial formation of omega-muricholic acid in rats.
In the feces of conventional rats, the amount of omega-muricholic and hyodeoxycholic acids vary according to the diet. To understand this phenomenon, we investigated the bacterial formation of these bile acids. The present paper reports the first isolation, from conventional rat feces, of a strain of Clostridium group III which transforms beta-muricholic acid, the main bile acid in germfree rats, into omega-muricholic acid.
D000818:Animals; D002793:Cholic Acids / Q000096:biosynthesis* / Q000378:metabolism; D003013:Clostridium / Q000378:metabolism* / Q000502:physiology; D004032:Diet; D005243:Feces / Q000382:microbiology; D005856:Germ-Free Life; D007535:Isomerases / Q000378:metabolism; D008297:Male; D051381:Rats
D002793:Cholic Acids; C004821:muricholic acid; D007535:Isomerases