Amide, 1-adamantylamide of leu-enkephalin and leu-[D Ala2]enkephalin.
The synthesis of Leu-enkephalinamide, Leu-enkephalin-1-adamantylamide, Leu-[D Ala2]enkephalinamide and Leu-[D Ala2]enkephalin-1-adamantylamide are described. Preliminary results of pharmacological tests in vitro are reported.
D000218:Adamantane / Q000031:analogs & derivatives / Q000138:chemical synthesis; D000577:Amides / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects; D002855:Chromatography, Thin Layer; D004723:Endorphins / Q000138:chemical synthesis*; D004745:Enkephalins / Q000138:chemical synthesis* / Q000494:pharmacology; D006168:Guinea Pigs; D006868:Hydrolysis; D007082:Ileum / Q000187:drug effects; D008297:Male; D051379:Mice; D013737:Testis / Q000187:drug effects
D000577:Amides; D004723:Endorphins; D004745:Enkephalins; D000218:Adamantane