title: [Endocrinologic and ophthalmologic findings before and after transnasal surgery in so-called chromophobe pituitary adenomas].
abstract: Pre- and postoperative visual and endocrine functions were examined in 54 patients with so-called chromophobe pituitary adenomas operated on by the transnasal approach. The preoperative examination showed visual disturbances in 41 of 48 patients. A loss of gonadal function was present in 93% of the women and 69% of the men. Impairment of adrenal function was found in 37% and of thyroid function in 18% of patients. Hyperprolactinemia was present in 16 of 29 patients examined. The visual findings remained unchanged, normal or improved in 75% of patients. Impairment occurred in 3%. Eight patients experienced improvement of gonadal function and 3 of adrenal function, whereas no postoperative improvement of the thyroid function was observed. Deterioration of gonadal function occurred in 4, of adrenal function in 7, and of thyroid function in 9 patients. Hyperprolactinemia was reduced in all cases.
mesh_terms: D015065:17-Hydroxycorticosteroids / Q000032:analysis; D015068:17-Ketosteroids / Q000032:analysis; D000238:Adenoma, Chromophobe / Q000601:surgery*; D000293:Adolescent; D000328:Adult; D000368:Aged; D007172:Erectile Dysfunction / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D008598:Menstruation; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000601:surgery*; D011388:Prolactin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000032:analysis; D014792:Visual Acuity; D014794:Visual Fields
chemical_list: D015065:17-Hydroxycorticosteroids; D015068:17-Ketosteroids; D014284:Triiodothyronine; D011388:Prolactin; D013974:Thyroxine
vernacular_title: Endokrinologische und ophthalmologische Befunde vor und nach transnasaler Operation bei sogenannten chromophoben Hypophysenadenomen.