Beta-thalassaemia: increased chromosomal anomalies in lymphocyte cultures.
Lymphocyte cultures from homozygotes for the beta-thalassaemia gene were found to contain chromosomal gaps, breaks, and rearrangements more often than those from controls. Culture time seemed to have a determinant effect on the results. The possible influence of folic acid deficiency is discussed.
D000293:Adolescent; D000328:Adult; D002478:Cells, Cultured; D002648:Child; D002842:Chromatids / Q000648:ultrastructure; D002869:Chromosome Aberrations; D006720:Homozygote; D006801:Humans; D007223:Infant; D008214:Lymphocytes / Q000648:ultrastructure*; D013789:Thalassemia / Q000097:blood / Q000235:genetics*; D013997:Time Factors