Glycolysis-dependent antimetabolities: possible improvement in antineoplastic selectivity.
The increased rate of glycolysis in neoplastic cells may be used to design tentatively antimetabolites whose detoxification would be faster in normal cells. Pyruvo-substituted nucleotides are examined in this respect and their expected differential metabolism outlined.
D000964:Antimetabolites, Antineoplastic / Q000378:metabolism* / Q000627:therapeutic use; D006019:Glycolysis; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D011685:Purine Nucleotides / Q000378:metabolism / Q000627:therapeutic use
D000964:Antimetabolites, Antineoplastic; D011685:Purine Nucleotides