Urethane and hydroxyurethane induce sister-chromatid exchanges in cultured human lymphocytes.
Both urethane and hydroxyurethane induced sister-chromatid exchanges (SCE) in cultured human lymphocytes. Aroclor-induced rat-liver microsome fraction deactivated rather than activated these two agents in the lymphocyte system.
D002842:Chromatids / Q000187:drug effects*; D002869:Chromosome Aberrations; D002877:Chromosomes, Human / Q000187:drug effects*; D003434:Crossing Over, Genetic; D004353:Drug Evaluation, Preclinical; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure; D009153:Mutagens; D014520:Urethane / Q000031:analogs & derivatives / Q000494:pharmacology*
D009153:Mutagens; D014520:Urethane