[Pharmacokinetic characteristics of salicylates in old animals].
Experimental study of absorption, distribution, metabolism and excretion of salicylic acid and salicylate upon ageing showed that the sodium salicylate absorption rate is considerably decreased in old rats and rabbits. As a result, the plasma of old animals shows the low content of salicylates compared to adult ones. The level of salicylic acid in tissues and capacity of serum protein for salicylate binding are decreased. Excretion of salicylates in old rats was delayed compared to that in adult ones, the half-life in old rats was 2--3 times as long as that in adult species. The revealed features of salicylate pharmacokinetics in old animals confirm advisability of their further study in order to determine adequate doses of the drugs to be applied in geriatrics and to prevent their adverse on the ageing organism.
D000375:Aging / Q000187:drug effects*; D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D005260:Female; D005609:Free Radicals; D007700:Kinetics; D011485:Protein Binding / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D012459:Salicylates / Q000378:metabolism*; D012980:Sodium Salicylate / Q000378:metabolism; D013045:Species Specificity; D013997:Time Factors; D014018:Tissue Distribution
D001798:Blood Proteins; D005609:Free Radicals; D012459:Salicylates; D012980:Sodium Salicylate
Ob osobennostiakh farmakokinetiki salitsilatov u starykh zhivotnykh.