[Fertility and the progeny of children surviving cancer treatment (author's transl)].
Little is known about the late effects of damage to the gonads in children treated for cancer. This investigation requires a prolonged surveillance. Radiotherapy sterilizes the ovaries above a dose of about 500 rads in an adult. Therefore, to protect at least one ovary in partial irradiation of a child's abdomen in mandatory whenever possible, either by restriction of the irradiated volume, or transposition of the ovary. Combined chemotherapies do not seem to inhibit endocrine function but it is too early to appreciate the effects of different combinations of drugs on reproductive function in girls. In boys, alkylating drugs cause an oligo or azoospermia, either temporary or permanently. The genetic risks in the descendants of children treated for cancer are still unknown.
D000293:Adolescent; D000328:Adult; D000477:Alkylating Agents / Q000009:adverse effects; D000970:Antineoplastic Agents / Q000009:adverse effects; D002648:Child; D005260:Female; D005298:Fertility / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D007247:Infertility, Female / Q000209:etiology; D008297:Male; D009369:Neoplasms / Q000235:genetics / Q000628:therapy*; D009845:Oligospermia / Q000139:chemically induced; D010053:Ovary / Q000528:radiation effects; D011247:Pregnancy; D011878:Radiotherapy / Q000009:adverse effects; D013997:Time Factors
D000477:Alkylating Agents; D000970:Antineoplastic Agents
Descendances et grossesses futures chez les enfants traités pour cancer.