Induction of dominant lethal mutations in male mice by fosfestrol.
Using the dominant lethal assay, the ability of fosfestrol, a diethylstilboestrol derivate, to induce mutations in male mice was tested and confirmed. Up to 300 mg/kg of fosfestrol the induction of mutations occurs exclusively in spermatozoa. A dose of 600 mg/kg of fosfestrol induces dominant lethal mutations up to 10 days posttreatment. The majority of induced dominant lethal mutations in all dose groups are expressed as loss after implantation.
D000818:Animals; D004054:Diethylstilbestrol / Q000009:adverse effects / Q000031:analogs & derivatives*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005804:Genes, Lethal; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009154:Mutation / Q000187:drug effects*; D013091:Spermatogenesis / Q000187:drug effects; D013997:Time Factors
D004054:Diethylstilbestrol