title: Metabolic and pharmacodynamic tolerance to ethanol in rats.
abstract: The development of tolerance to ethanol was studied in rats fed nutritionally adequate liquid diets containing ethanol or sucrose for up to 5 weeks. Tolerance was shown to be due to both metabolic and pharmacodynamic factors. Tolerance began to develop after 3 days of ethanol intake, reached a plateau by 16 days and persisted for up to 22 days after stopping the ethanol intake. The rate of onset and decay of both components of tolerance was similar.
mesh_terms: D000428:Alcohol Drinking; D000818:Animals; D001921:Brain / Q000378:metabolism; D004032:Diet; D004361:Drug Tolerance; D000431:Ethanol / Q000097:blood / Q000378:metabolism / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D051381:Rats; D012890:Sleep / Q000187:drug effects; D013997:Time Factors
chemical_list: D000431:Ethanol