title: Chicken ovalbumin contains an internal signal sequence.
abstract: Ovalbumin is shown to contain an internal rather than an amino-terminal signal sequence. This internal signal can be recovered in a tryptic fragment which comprises residues 229--276 of mature ovalbumin and contains a region of striking sequence homology to amino-terminal cleaved signals of two other oviduct secretory proteins. The isolated tryptic fragment is used as a probe to demonstrate that a signal receptor is present in membrane vesicles derived from the rough but not in those derived from the smooth endoplasmic reticulum.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001692:Biological Transport; D002645:Chickens; D004721:Endoplasmic Reticulum / Q000378:metabolism; D005260:Female; D010047:Ovalbumin / Q000096:biosynthesis / Q000378:metabolism*; D010446:Peptide Fragments / Q000378:metabolism; D011388:Prolactin / Q000378:metabolism; D011487:Protein Conformation; D011498:Protein Precursors / Q000378:metabolism; D014357:Trypsin
chemical_list: D010446:Peptide Fragments; D011498:Protein Precursors; D011388:Prolactin; D010047:Ovalbumin; D014357:Trypsin