[Comparative study of the effect of decamethoxine, decamine and levorin on carbohydrate metabolic indices in the liver of white rats].
Intramuscular injection of decamin into the animals in a dose of 0.5 and 1 mg/kg has no significant effect on carbohydrate metabolism in the liver of white rats. Decamethoxin and levorin injected in the same doses, specifically in a dose of 1 mg/kg, reduced the level of glucose as well as that of total and free glycogen in the liver. The drugs lowered also the activity of phosphorylase and glocoso-6-phosphatase. Meanwhile the activity of hexokinase, lactate dehydrogenase and phosphoglucosiomerase was potentiated. The animals given decamethoxin showed the aforesaid parameters returning to normal 20 days after the drug was discontinued, whereas similar changes were not found in the rats on levorin.
D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D002174:Candicidin / Q000494:pharmacology*; D050260:Carbohydrate Metabolism; D003650:Decamethonium Compounds / Q000494:pharmacology*; D003868:Dequalinium / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D011806:Quinolinium Compounds / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D000935:Antifungal Agents; D003650:Decamethonium Compounds; D008112:Liver Glycogen; D011806:Quinolinium Compounds; D002174:Candicidin; D003868:Dequalinium
Sravnitel'noe izuchenie vliianiia dekametoksina, dekamina i levorina na pokazateli uglevodnogo obmena v pecheni belykh krys.