Inability of imipramine to protect against type A or type B monoamine oxidase inhibition by pargyline.
Imipramine (30 mg/kg i.p.) did not antagonize the inhibition of either type A or type B MAO by pargyline in brain, heart or liver of rats. Occupancy of active sites on mitochondrial MAO by imipramine probably does not occur at doses of imipramine adequate to inhibit monoamine uptake.
D000818:Animals; D001921:Brain / Q000201:enzymology; D007099:Imipramine / Q000494:pharmacology*; D008099:Liver / Q000201:enzymology; D008297:Male; D008996:Monoamine Oxidase Inhibitors / Q000037:antagonists & inhibitors*; D009206:Myocardium / Q000201:enzymology; D010293:Pargyline / Q000037:antagonists & inhibitors*; D051381:Rats
D008996:Monoamine Oxidase Inhibitors; D010293:Pargyline; D007099:Imipramine