Metabolism of 2-chloro-N-isopropylacetanilide (propachlor) in the rat.
Eleven urinary metabolites from [14C]propachlor were either identified or characterized by mass spectrometry. Those identified were 2-[S-(N-acetyl)cysteinyl]-N-isopropylacetanilide, 2-(methylsulfonyl)-acetanilide, 4'-hydroxy-2-(methylsulfonyl)-acetanilide, and 4'-hydroxyacetanilide. Those characterized were N-(1-hydroxyisopropyl)-2-(methylsulfonyl) acetanilide and its glucuronide, the glucuronides of 4'-hydroxy-N-isopropyl-2-(methylsulfonyl)acetanilide, N-(1-hydroxyisopropyl) aniline, 4'-hydroxy-2-(methylsulfonyl)acetanilide, and either N-(1-hydroxy-isopropyl) acetanilide or 2-hydroxy-N-isopropylacetanilide.
D000083:Acetanilides / Q000378:metabolism* / Q000652:urine; D000818:Animals; D001711:Biotransformation; D005965:Glucuronates / Q000378:metabolism; D006540:Herbicides / Q000378:metabolism* / Q000652:urine; D006868:Hydrolysis; D051381:Rats
D000083:Acetanilides; D005965:Glucuronates; D006540:Herbicides