alpha-Mercaptopropionyl-glycine influence on the in vitro proliferative response of human lymphocytes.
The effect of alpha-mercaptopropinyl-glycine on the in vitro proliferative response of healthy subjects' lymphocytes was studied. Low doses of the drug enhanced spontaneous lymphocyte blastigenesis but had no effect on the PHA-induced blastic response. With increasing concentrations of alpha-mercaptopropionyl-glycine inhibition of 3H-thymidine incorporation was found in unstimulated as well as in PHA stimulated lymphocytes.
D000603:Amino Acids, Sulfur / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis; D006801:Humans; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000187:drug effects / Q000502:physiology*; D013936:Thymidine / Q000378:metabolism; D008625:Tiopronin / Q000494:pharmacology*
D000603:Amino Acids, Sulfur; D004247:DNA; D008625:Tiopronin; D013936:Thymidine