ECHOvirus 33 replication in human peripheral white blood cells.
ECHOvirus 33 isolated from the cerebrospinal fluid of a patient with agammaglobulinemia was shown to replicate in vitro in peripheral leukocyte suspensions from a normal antibody negative donor. Replication was demonstrated by use of sequential dilution experiments. Washed glass adherent mononuclear cell cultures from a normal antibody negative donor were also capable of supporting ECHOvirus 33 replication in vitro. Leukocyte suspensions from the infected agammaglobulinemic patient extinguished detectable infectious virus in vitro.
D000361:Agammaglobulinemia / Q000276:immunology / Q000382:microbiology; D000914:Antibodies, Viral; D002478:Cells, Cultured; D002555:Cerebrospinal Fluid / Q000382:microbiology; D029822:Enterovirus B, Human / Q000254:growth & development* / Q000276:immunology; D006801:Humans; D007962:Leukocytes / Q000276:immunology / Q000382:microbiology*; D008297:Male; D009000:Monocytes / Q000382:microbiology; D014779:Virus Replication
D000914:Antibodies, Viral