title: Abnormal orientation selectivity in both eyes of strabismic amblyopes.
abstract: In normal observers preadaptation to a parallel grating increases the contrast threshold for a line whereas a perpendicular grating has no effect. Such orientation selectivity was not found in the amblyopic eye of two out of five squinters. Only a weak after-effect produced with a grating parallel to the line was obtained in the good eye of four of the amblyopes while all of them show an abnormal threshold reduction following adaptation to a perpendicular grating. This suggests a relationship between abnormal binocular interaction during visual development and the organization of orientational mechanisms but does not explain the loss of visual acuity in amblyopia.
mesh_terms: D000221:Adaptation, Ocular; D000550:Amblyopia / Q000503:physiopathology*; D006801:Humans; D013285:Strabismus / Q000503:physiopathology*; D014792:Visual Acuity