Effect of glycerol on viability and other properties of starved Mycobacterium fortuitum.
Cells of Mycobacterium fortuitum kept in 0.85% saline solution containing 0.1% Tween 80 (without glycerol) survive for a long time. In glycerol-enriched medium, they continue to lose their viability at a high rate; after 71 days of exposure the percentage of survival as indicated by colony formation and respiratory and dehydrogenase activities is lower than 1%. Surviving cells starved in medium without glycerol revealed unchanged sensitivity to streptomycin, p-aminosalicylic acid, and isoniazid.
D000995:Antitubercular Agents / Q000494:pharmacology; D003470:Culture Media; D004352:Drug Resistance, Microbial; D005990:Glycerol / Q000494:pharmacology*; D009161:Mycobacterium / Q000187:drug effects* / Q000378:metabolism; D010088:Oxidoreductases / Q000378:metabolism; D010101:Oxygen Consumption; D012965:Sodium Chloride
D000995:Antitubercular Agents; D003470:Culture Media; D012965:Sodium Chloride; D010088:Oxidoreductases; D005990:Glycerol