Screening for Cushing's syndrome using early morning urine samples.
Urinary free 11-hydroxycorticosteroid/creatinine ratios (UFC/Cr)were determined in early morning urine samples from 138 obese subjects attending endocrine clinics in the Glasgow area. The majority of patients (128) had UFC/Cr ratios within the normal range for non-obese subjects (5-55 mumol/mol). Of those with elevated UFC/Cr ratios, further investigations of the hypothalamic-pituitary-adrenal axis confirmed a diagnosis of Cushing's syndrome due to bilateral adrenal hyperplasia in six of the cases and adrenal tumours in a further two patients. In the remaining two patients there was evidence of intermittent adrenal hyperactivity with inconsistent responses to insulin-induced hypoglycaemia tests.
D015062:11-Hydroxycorticosteroids / Q000652:urine*; D000293:Adolescent; D000310:Adrenal Gland Neoplasms / Q000652:urine; D000308:Adrenocortical Hyperfunction / Q000188:drug therapy; D000328:Adult; D000368:Aged; D002648:Child; D003404:Creatinine / Q000652:urine*; D003480:Cushing Syndrome / Q000150:complications / Q000175:diagnosis* / Q000652:urine; D003907:Dexamethasone / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006965:Hyperplasia; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000175:diagnosis / Q000652:urine*
D015062:11-Hydroxycorticosteroids; D003907:Dexamethasone; D003404:Creatinine