title: [Dynamics of the connective tissue changes in rats in the process of tumor formation induced by ethacryl (AKR-15) plastic].
abstract: Morphological studies of the rat connective tissue around the implanted plates, made from a plastic Ethacryl (AKP-15) being employed in orthopedic stomatology, have demonstrated a gradual reduction of the proliferative activity of the connective tissue capsule fibroblasts, followed 6 months later by the appearance of diffuse and then focal proliferates in the internal layer with subsequent development of tumors. A histological assay of the collagen-formation revealed no dystrophic changes in the connective tissue characteristic of other types of blastomogenesis. The pattern of diformazane depositing, when histochemically assaying oxido-reduction enzymes, may evidence the cell damage of the connective tissue capsules around the implant in the first months of the experiment.
mesh_terms: D000180:Acrylic Resins; D000287:Administration, Topical; D000818:Animals; D002273:Carcinogens; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D003238:Connective Tissue / Q000187:drug effects* / Q000201:enzymology; D004789:Enzyme Activation / Q000187:drug effects; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D010088:Oxidoreductases / Q000378:metabolism; D010969:Plastics; D051381:Rats; D012878:Skin Neoplasms / Q000139:chemically induced; D013997:Time Factors
chemical_list: D000180:Acrylic Resins; D002273:Carcinogens; D010969:Plastics; C020315:etacryl; D010088:Oxidoreductases
vernacular_title: Dinamika izmeneniĭ soedinitel'noĭ tkani krys v protsesse formirovanie opukholeĭ, vyzvannykh plastmassoĭ étakril (AKR-15).