title: 4-aminobutyrate:2-oxoglutarate aminotransferase in blood platelets.
abstract: Platelet lysates obtained from blood of humans, dogs, and rats catalyzed the transamination of 4-aminobutyrate with 2-oxoglutarate as cosubstrate. Human platelet 4-aminobutyrate:2-oxoglutarate aminotransferase (36.5 +/- 3.2 picomoles per minute per milligram of platelet protein) resembled the brain enzyme in kinetic properties and in response to cofactors and inhibitors.
mesh_terms: D000612:4-Aminobutyrate Transaminase / Q000097:blood*; D000818:Animals; D001792:Blood Platelets / Q000201:enzymology*; D001921:Brain / Q000201:enzymology; D004285:Dogs; D004789:Enzyme Activation / Q000187:drug effects; D006801:Humans; D007700:Kinetics; D011732:Pyridoxal Phosphate / Q000494:pharmacology; D051381:Rats; D013379:Substrate Specificity; D000637:Transaminases / Q000097:blood*; D005680:gamma-Aminobutyric Acid / Q000097:blood
chemical_list: D005680:gamma-Aminobutyric Acid; D011732:Pyridoxal Phosphate; D000637:Transaminases; D000612:4-Aminobutyrate Transaminase