Epidermal-dermal recombinations with embryonic naked and normal back skin of Gallus domesticus.
Birds exhibiting a varying featherless condition resulting from the recessive sex-linked gene naked (n) were used to investigate whether the gene altered the dermis or the epidermis. By splitting 7-day normal and naked skin into its dermal and epidermal components, and heterotypically recombining and growing it in chambers on the chorio-allantoic membrane (CAM), it was found that the epidermis of the naked birds is the site of mutant gene action. A histological study of developing normal and naked skin was done and the structure of the naked feather is elucidated.
D000818:Animals; D002478:Cells, Cultured; D002642:Chick Embryo / Q000254:growth & development*; D002645:Chickens / Q000235:genetics*; D004627:Embryonic Induction; D000078404:Epidermal Cells; D004817:Epidermis / Q000196:embryology; D005241:Feathers / Q000196:embryology*; D008648:Mesoderm / Q000166:cytology / Q000502:physiology; D009154:Mutation; D012867:Skin / Q000196:embryology