title: Use of iminodiacetic acid for the synthesis of piperazinyl peptides related to leu-enkephalin. II.
abstract: Piperazinyl peptides related to Leu-enkephalin were obtained using as intermediates condensation products with iminodiacetic acid. The products are devoid of analgesic activity.
mesh_terms: D000818:Animals; D004723:Endorphins / Q000138:chemical synthesis*; D004745:Enkephalins / Q000138:chemical synthesis* / Q000494:pharmacology; D005998:Glycine / Q000031:analogs & derivatives; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D007098:Imino Acids; D007930:Leucine; D008297:Male; D051379:Mice; D010455:Peptides / Q000138:chemical synthesis / Q000494:pharmacology; D010879:Piperazines / Q000138:chemical synthesis* / Q000494:pharmacology; D014649:Vas Deferens / Q000187:drug effects
chemical_list: D004723:Endorphins; D004745:Enkephalins; D007098:Imino Acids; D010455:Peptides; D010879:Piperazines; D007930:Leucine; D005998:Glycine