The formation of phosphatidylinositol by acylation of 2-acyl-sn-glycero-3-phosphorylinositol in rat liver microsomes.
The conversion of 2-acyl-sn-glycero-3-phosphorylinositol into phosphatidylinositol via acyl-CoA: 2-acyl-sn-glycero-3-phosphorylinositol acyltransferase activity was found to occur in rat liver microsomes. Over a wide range of conditions, stearic acid was preferred over palmitate by the acyltransferase when these acids were presented in mixtures as acyl-CoA derivatives. The potential importance of this enzyme activity for the entry of stearic acid into the 1-position of hepatic phosphatidylinositol is further supported by its greater preference for stearate relative to the acyl-CoA:2-acyl-sn-glycero-3-phosphorylcholine acyltransferase under certain assay conditions.
D000102:Acetyl-CoA C-Acyltransferase / Q000378:metabolism*; D000215:Acylation; D000217:Acyltransferases / Q000378:metabolism*; D000818:Animals; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism*; D010169:Palmitic Acids / Q000378:metabolism; D010716:Phosphatidylinositols / Q000096:biosynthesis*; D051381:Rats; D013229:Stearic Acids / Q000378:metabolism
D010169:Palmitic Acids; D010716:Phosphatidylinositols; D013229:Stearic Acids; D000217:Acyltransferases; D000102:Acetyl-CoA C-Acyltransferase