Hypernatremic hemorrhagic encephalopathy.
A 12-year-old juvenile diabetic was inadvertently given 500 ml of hypertonic saline intravenously. He developed hypernatremia, hyperosmolality, metabolic acidosis, and hyperglycemia. Seizures and stupor ensued, followed by coma and death. Computerized cranial tomography revealed numerous small subcortical hemorrhages that were verified postmortem.
D000038:Abscess / Q000209:etiology; D001921:Brain / Q000473:pathology; D002543:Cerebral Hemorrhage / Q000209:etiology* / Q000473:pathology; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D006801:Humans; D006955:Hypernatremia / Q000139:chemically induced* / Q000378:metabolism; D007275:Injections, Intravenous / Q000009:adverse effects*; D008297:Male; D008508:Medication Errors; D012462:Saline Solution, Hypertonic / Q000009:adverse effects*; D012965:Sodium Chloride / Q000009:adverse effects*
D012462:Saline Solution, Hypertonic; D012965:Sodium Chloride