The effect of substrate on the uptake of oxygen and sulphate ions by heat-damaged skin.
Respiration and sulphate uptake have been measured in guinea-pig skin subjected to heat damage and maintained on a medium containing sodium succinate. Succinate was found to have a protective effect against loss of oxygen uptake, a higher temperature being required for 50% effect than that reported with glucose as substrate. The protective effect did not extend to sulphate incorporation, suggesting that this process is itself heat-labile and that its failure with heat damage is not directly caused by diminution of the energy supply.
D000818:Animals; D002056:Burns / Q000378:metabolism*; D005947:Glucose / Q000494:pharmacology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D010101:Oxygen Consumption / Q000187:drug effects*; D012867:Skin / Q000187:drug effects / Q000378:metabolism*; D013386:Succinates / Q000494:pharmacology*; D013431:Sulfates / Q000378:metabolism*
D013386:Succinates; D013431:Sulfates; D005947:Glucose