[Disorders of dopamine and 5-hydroxytryptamine metabolism in the early period after cranio-cerebral injuries].
In patients with signs of intracranial hypertension caused by subdural haematoma or brain oedema following craniocerebral trauma significantly increased concentrations of HVA and 5-HIAA were found in the cerebrospinal fluid obtained by means of lumbar punction in relation to a control group comprising patients with lumbar disc prolapse. In patients after craniocerebral injuries with open fracture of cranial bones without disturbances of consciousness dopaminergic system hyperactivity was observed lasting up to the 7th day after injury. In patients with symptoms of brain commotion after craniocerebral trauma a significant rise in 5-HIAA concentration was observed in the cerebrospinal fluid on the 7th day after trauma. This may suggest increased serotonin turnover early after trauma.
D000328:Adult; D001924:Brain Concussion / Q000134:cerebrospinal fluid*; D002555:Cerebrospinal Fluid / Q000378:metabolism*; D004298:Dopamine / Q000134:cerebrospinal fluid*; D005260:Female; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D008297:Male; D008875:Middle Aged; D012701:Serotonin / Q000134:cerebrospinal fluid*; D012887:Skull Fractures / Q000134:cerebrospinal fluid*; D013997:Time Factors
D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D004298:Dopamine; D006719:Homovanillic Acid
Zaburzenia metabolizmu dopaminy i 5-hydroksytryptaminy u chorych we wczesnym okresie po urazach czaszkowo-mózgowych.