[Metabolic products of microorganisms. 175. Tetracenomycin C (author's transl)].
Streptomyces glaucescens, strain Tü 49 = ETH 22794, produces hydroxystreptomycin as well as the tetracenomycins, a mixture of several lipophilic antibiotics. The main component and the most active one is tetracenomycin C. Tetracenomycin C has a molecular formula C23H20O11 and is chemically related to tetracyclines and anthracyclinones. The pale yellow antibiotic is active against some gram-positive bacteria, especially against streptomycetes. Gram-negative bacteria and fungi are not inhibited. In considering the differences of biological activity and the functional groups of the molecule, tetracenomycin C is not a member of the tetracycline or anthracyclinone group of antibiotics.
D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D009279:Naphthacenes; D010452:Peptide Biosynthesis; D013045:Species Specificity; D013302:Streptomyces / Q000187:drug effects / Q000378:metabolism*; D013754:Tetracyclines / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D009279:Naphthacenes; D013754:Tetracyclines; C020938:tetracenomycin C
Stoffwechselprodukte von Mikroorganismen. 175. Mitteilung. Tetracenomycin C.