Blocking by picrotoxin of nigra-evoked inhibition of neurons of ventromedial nucleus of the thalamus.
The transmitter substance realeased by nigro-thalamic fibres is proposed to be gamma-aminobutyric acid, since picrotoxin blocked nigra-evoked monosynaptic inhibition of thalamic neurons.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002415:Cats; D018756:GABA Antagonists; D009433:Neural Inhibition / Q000187:drug effects*; D009434:Neural Pathways / Q000187:drug effects; D010852:Picrotoxin / Q000494:pharmacology*; D013378:Substantia Nigra / Q000502:physiology*; D013787:Thalamic Nuclei / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D018756:GABA Antagonists; D010852:Picrotoxin; D005680:gamma-Aminobutyric Acid