title: The influence of ethanol treatment of cytogenetic effects in bone marrow cells of Chinese hamsters by cyclophosphamide, aflatoxin B1 and patulin.
abstract: Chromosomes were investigated from the bone marrow of Chinese hamsters which received 10% (v/v) ethanol as the only liquid supply for a period of 9 weeks. At the end of the ethanol drinking period 1 group of animals received 2 oral doses of 80 mg/kg cyclophosphamide (CP), a second group received 2 oral doses of 25 mg/kg aflatoxin B1 (AFB1), a third group 2 oral doses of 20 mg/kg patulin (PA). The 2  applications were separated by 24 h. The intake of ethanol had no effect on the bone marrow chromosomes, and had no potentiating effect on CP induced aberrations. 9 weeks consumption of 10% (v/v) ethanol revealed likewise no influence on the frequencies of chromosomal aberrations induced by the indirect mutagen AFB1. However, the rate of chromosomal aberrations induced by the direct mutagen PA was clearly suppressed in ethanol drinking animals.
mesh_terms: D000348:Aflatoxins / Q000494:pharmacology*; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects*; D006224:Cricetinae; D003412:Cricetulus; D003520:Cyclophosphamide / Q000494:pharmacology*; D004326:Drinking / Q000187:drug effects; D004347:Drug Interactions; D004435:Eating / Q000187:drug effects; D000431:Ethanol / Q000494:pharmacology*; D008938:Mitosis / Q000187:drug effects; D010365:Patulin / Q000494:pharmacology*; D011714:Pyrans / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D000348:Aflatoxins; D011714:Pyrans; D000431:Ethanol; D003520:Cyclophosphamide; D010365:Patulin