title: Isolation and characterization of gangliosides with a new sialosyl linkage and core structures. II. Gangliosides of human erythrocyte membranes.
abstract: Eight monosialosylgangliosides, G1 to G8, have been isolated from human erythrocyte membranes and their structures have been determined. Gangliosides G4 and G7 have been characterized by having 2 leads to 6-linked sialic acid to galactose at their termini. Ganglioside G5 was a positional isomer of a brain ganglioside GM1 as to the linkage of sialic acid. Ganglioside G8 was characterized as a branched chain ganglioside similar to a fucoganglioside previously isolated but devoid of fucose, and it showed a strong blood group I activity. Structures of these four new gangliosides are shown below: (formula: see text).
mesh_terms: D002241:Carbohydrates / Q000032:analysis; D004910:Erythrocyte Membrane / Q000032:analysis*; D004912:Erythrocytes / Q000032:analysis*; D005732:Gangliosides / Q000097:blood* / Q000302:isolation & purification; D006801:Humans; D008565:Membrane Proteins / Q000097:blood*; D008968:Molecular Conformation; D012794:Sialic Acids
chemical_list: D002241:Carbohydrates; D005732:Gangliosides; D008565:Membrane Proteins; D012794:Sialic Acids