title: Chronic active hepatitis in dogs associated with leptospires.
abstract: Chronic active hepatitis was diagnosed in five American Foxhounds from one kennel. Spirochetes were demonstrated in the liver in four of the dogs. A rising titer to Leptospira interrogans serovar grippotyphosa was found in the fifth dog, although spirochetes were not demonstrated in tissues. A serologic survey at the kennel revealed evidence of exposure of 6 of 13 dogs to grippotyphosa. This is the first report of an association between chronic active hepatitis leptospiral infection in any species.
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D004283:Dog Diseases / Q000209:etiology / Q000473:pathology; D004285:Dogs; D005260:Female; D006520:Hepatitis, Animal / Q000209:etiology* / Q000473:pathology; D007668:Kidney / Q000473:pathology; D007921:Leptospira interrogans / Q000276:immunology; D007922:Leptospirosis / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D008099:Liver / Q000473:pathology; D008297:Male
chemical_list: D000907:Antibodies, Bacterial