The effect of non-narcotic analgesic, tramadol, on cardiac contractility in dog.
The effect of a non-narcotic analgesic, tramadol, 5 mg/kg i.v. on cardiac contractility was studied in intact dog. The maximal intrinsic velocity of contraction of the ventricle, dP/dt/K P at P=O(Vmax) which is a most sensitive and reliable index of cardiac contractility, was decreased significantly 5 and 10 min after the injection, suggesting that the drug is a mild myocardial depressant at this dose and by this route.
D000818:Animals; D003511:Cyclohexanols / Q000494:pharmacology*; D004285:Dogs; D009200:Myocardial Contraction / Q000187:drug effects*; D014147:Tramadol / Q000494:pharmacology*
D003511:Cyclohexanols; D014147:Tramadol