Counteraction of testosterone-induced suppression of the pituitary-ovarian axis in rats by flutamide.
Daily administration of 100 micrograms of testosterone to unilaterally ovariectomized rats for 18 days caused a significant decrease in compensatory ovarian hypertrophy. The number of corpora lutea was markedly reduced and many cystic follicles were noticeable. Administration of graded doses (0.5, 1 and 3 mg daily) of flutamide over the same period did not cause any significant change in the weight and histology of the ovary in untreated unilaterally ovariectomized animals. However, treatment with the same doses of flutamide prevented the changes observed in the reamining ovary of testosterone-treated animals.
D000813:Anilides / Q000494:pharmacology*; D000818:Animals; D002369:Castration; D003338:Corpus Luteum / Q000187:drug effects; D005260:Female; D005485:Flutamide / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D010048:Ovarian Cysts; D010053:Ovary / Q000187:drug effects / Q000502:physiology*; D010060:Ovulation / Q000187:drug effects; D051381:Rats; D013739:Testosterone / Q000037:antagonists & inhibitors / Q000494:pharmacology*
D000813:Anilides; D013739:Testosterone; D005485:Flutamide