Stochastic models for X chromosome inactivation.
A multivariate Gaussian model for mammalian development is presented with the associated biological and mathematical assumptions. Many biological investigations use the female mammal X chromosome to test hypotheses and to estimate parameters of the developmental system. In particular, Lyon's (1961) hypotheses are used as a basis of the mathematical model. Experimental mouse data and three sets of human experimental data are analyzed using the hypothesized Gaussian model. The estimated biological parameters are consistent with some current biological theories.
D000818:Animals; D002477:Cells / Q000648:ultrastructure; D004622:Embryo, Mammalian / Q000166:cytology; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000235:genetics; D006579:Heterozygote; D006801:Humans; D007041:Hypoxanthine Phosphoribosyltransferase / Q000172:deficiency; D008433:Mathematics; D051379:Mice; D008954:Models, Biological; D009030:Mosaicism; D010641:Phenotype; D012730:Sex Chromosomes; D013269:Stochastic Processes; D014178:Translocation, Genetic; D014960:X Chromosome
D005954:Glucosephosphate Dehydrogenase; D007041:Hypoxanthine Phosphoribosyltransferase