Effects of pantetheine on cholesteryl ester synthesis in the arterial wall of rats on high cholesterol diet.
Increase of acyl-CoA synthesis was observed when extracts of rat arterial wall were incubated with pantetheine [D-bis-(N-pantothenyl-beta-aminoethyl)-disulfide]. Cholesteryl ester synthesis from palmitate in the arterial wall extract in vitro was higher with arteries from rats on high cholesterol diet than with those from rats on normal diet, but the synthesis was reduced in the arteries of rats on high cholesterol diet with pantetheine. Triglyceride synthesis was higher with arterial wall extracts of rats on high cholesterol diet than with preparations from rats on normal diet and was not reduced with those of rats on high cholesterol diet plus pantetheine. The value of the effects of pantetheine on lipid metabolism in the prevention of atherosclerosis is pointed out.
D000214:Acyl Coenzyme A / Q000096:biosynthesis; D000818:Animals; D001158:Arteries / Q000187:drug effects / Q000378:metabolism*; D001161:Arteriosclerosis / Q000517:prevention & control; D002788:Cholesterol Esters / Q000096:biosynthesis*; D002791:Cholesterol, Dietary / Q000008:administration & dosage*; D008297:Male; D010204:Pantetheine / Q000494:pharmacology*; D010743:Phospholipids / Q000096:biosynthesis; D051381:Rats; D013438:Sulfhydryl Compounds / Q000494:pharmacology*; D014280:Triglycerides / Q000096:biosynthesis
D000214:Acyl Coenzyme A; D002788:Cholesterol Esters; D002791:Cholesterol, Dietary; D010743:Phospholipids; D013438:Sulfhydryl Compounds; D014280:Triglycerides; D010204:Pantetheine