title: Chronic implanting of electrodes in the cerebellar vermis of the cat. Morphological findings.
abstract: The morphological modifications of the cerebellar cortex have been evaluated in eight cats with chronic electrodes implanted in the anterior vermis. In a control animal a silastic lamina without electrodes was implanted. Four animals received intermittent stimulations up to 11 hours in one case and 100 hours in the other 3. The stimulation was carried out with pulses of 0.5 msc, 200 cps, and a charge per phase of 0.68 muc. Microscopic examination of the cerebellum showed that the experimental implanting of prostheses of the cerebellar vermis produces tissue lesions consisting of fibrous reaction, imprinting of the cortex, gliosis, and loss of Purkinje cells. These lesions are independent of the electric stimulation, and seem to be related to the pressure of foreign material against the cortex.
mesh_terms: D000818:Animals; D002415:Cats; D002525:Cerebellar Cortex / Q000293:injuries* / Q000473:pathology; D004558:Electric Stimulation / Q000009:adverse effects; D004567:Electrodes, Implanted; D005911:Gliosis; D011689:Purkinje Cells