Correct axonal regeneration after target cell removal in the central nervous system of the leech.
The unique target neuron of a severed axon in the leech was selectively eliminated by intracellular injection of protease. In the absence of the target, the severed axon regenerated normally along its original pathway to the usual site of synapse, where it stopped growing without forming alternative connections.
D000818:Animals; D002450:Cell Communication; D002490:Central Nervous System / Q000254:growth & development / Q000502:physiology; D007865:Leeches / Q000502:physiology*; D009416:Nerve Regeneration; D013569:Synapses / Q000502:physiology