Polycythemia produced in rats by environmental contaminants.
Polycythemia developed in progeny from mothers who were exposed during pregnancy to a combination of methylmercury chloride plus ethylurea and sodium nitrite. The polycythemia occurred as early as one month of age and as many as 24% of the offspring developed the polycythemic condition. Many features of this condition are similar to those of polycythemia vera in man, such as elevated hematocrits and white and red blood cell counts, splenomegaly, and hyperplasia of bone marrow accompanied by megakaryocytosis.
D000818:Animals; D004785:Environmental Pollutants; D005260:Female; D006321:Heart / Q000033:anatomy & histology; D009573:Nitrites; D009929:Organ Size / Q000187:drug effects; D009941:Organomercury Compounds; D011086:Polycythemia / Q000139:chemically induced*; D051381:Rats; D013154:Spleen / Q000033:anatomy & histology; D014508:Urea / Q000031:analogs & derivatives*
D004785:Environmental Pollutants; D009573:Nitrites; D009941:Organomercury Compounds; D014508:Urea