In vitro sensitization of human lymphocytes against allogeneic cells by antigen-fed macrophages.
Primary in vitro sensitization of human lymphocytes against allogeneic tumor cells was induced by antigen-fed macrophages. Spleen or peripheral blood macrophages were fed with cell-free extracts of allogeneic tumor cells. Autologous lymphocytes that were sensitized by the macrophage culture for five days manifested cytotoxic activity against the corresponding target cells.
D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology*; D002460:Cell Line; D003602:Cytotoxicity, Immunologic; D006801:Humans; D007942:Leukemia, Experimental / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology*; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D009374:Neoplasms, Experimental / Q000276:immunology; D012208:Rhabdomyosarcoma / Q000276:immunology*; D013154:Spleen / Q000276:immunology; D013724:Teratoma / Q000276:immunology*
D000951:Antigens, Neoplasm