Red cell glyoxalase I polymorphism in Italians. Report of a variant phenotype.
The glyoxalase I polymorphism was studied in 1,490 unrelated subjects from three different areas of Italy (Milan, Rome and Naples). The following frequencies of GLO2 allele were observed: Milan 0.57, Rome 0.59, Naples 0.61, and a significant difference between Milan and Naples was found (p less than 0.02). An anomalous phenotype is also described which permits us to postulate a new allele producing an isozyme with low activity and electrophoretically slower than those corresponding to GLO1 and GLO2 alleles.
D000293:Adolescent; D000328:Adult; D000483:Alleles; D004912:Erythrocytes / Q000201:enzymology*; D005787:Gene Frequency; D006801:Humans; D007231:Infant, Newborn; D007558:Italy; D007791:Lactoylglutathione Lyase / Q000097:blood / Q000235:genetics*; D008190:Lyases / Q000235:genetics*; D010641:Phenotype; D011110:Polymorphism, Genetic
D008190:Lyases; D007791:Lactoylglutathione Lyase