Morphometric and cytophotometric investigations of lobular neoplasia of the breast with ductal involvement.
The two different types, A and B, of in situ lobular neoplasia of the breast can be distinguished by cytomorphological means. DNA-measurements of type A are preponderantly diploid while those of type B vary from diploidy to hyperteraploidy with a maximum in the hyperdiploid range. The results indicate a higher potential of malignancy in type B. Homogenous ductular cell proliferations in the immediate neighbourhood of a lobular neoplasia display virtually the same distribution of DNA-values. Such evidence suggests that ductular changes and concomitant intralobular lesions have a common genesis, showing also a similar tendency towards malignant changes.
D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000473:pathology*; D002278:Carcinoma in Situ / Q000473:pathology*; D002452:Cell Count; D002455:Cell Division; D002467:Cell Nucleus / Q000648:ultrastructure; D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D006801:Humans
D004273:DNA, Neoplasm