[Dependence of the nephrotoxic effect of kanamycin on its concentration in the blood (an experimental study)].
The kinetics of changes in the urea nitrogen level of the serum was studied experimentally on narcotized cats with constant blood levels of kanamycin. A relationship between the intensity of the nephrotoxic effect of kanamycin and its blood level was found. On the basis of this relationship lower nephrotoxicity of kanamycin as compared to that of gentamicin and streptomycin under conditions of their constant blood levels was shown. However, the concentrations of gentamicin and kanamycin provided in the blood by their use in therapeutic doses differeing 3--4 times allow a conclusion that the nephrotoxic effect of kanamycin and gentamicin to be practically the same.
D000818:Animals; D001806:Blood Urea Nitrogen; D002415:Cats; D004305:Dose-Response Relationship, Drug; D005260:Female; D005839:Gentamicins / Q000633:toxicity; D007612:Kanamycin / Q000008:administration & dosage / Q000097:blood / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects*; D007700:Kinetics; D008297:Male; D008433:Mathematics; D008954:Models, Biological; D013307:Streptomycin / Q000633:toxicity; D013997:Time Factors
D005839:Gentamicins; D007612:Kanamycin; D013307:Streptomycin
Zavisimost' nefrotoksicheskogo éffekta kanamitsina ot ego kontsentratsii v krovi (éksperimental'noe issledovanie).