title: Vitrectomy in experimental endophthalmitis: Part I-Fungal infection.
abstract: In studying the dose-related ocular toxicity of amphotericin B in vitrectomized eyes, up to 5 micrograms/0.1 ml concentration of amphotericin C was nontoxic to the ocular structure when injected in the anterior part of the vitreous cavity. Intravitreal injection of 2.5 micrograms of amphotericin B halted fungal endophthalmitis, which was experimentally induced in rabbit eyes, even after 16 days of infection. Combined treatment of vitrectomy and intravitreal injection of amphotericin B not only cured the fungal endophthalmitis but it also cleared the ocular media from opacities.
mesh_terms: D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use / Q000633:toxicity; D000818:Animals; D002177:Candidiasis / Q000188:drug therapy / Q000601:surgery*; D004305:Dose-Response Relationship, Drug; D005069:Evaluation Studies as Topic; D005128:Eye Diseases / Q000188:drug therapy / Q000601:surgery*; D011817:Rabbits; D014822:Vitreous Body / Q000601:surgery*
chemical_list: D000666:Amphotericin B