Histoplasmosis: clinical syndromes and management.
The fungus Histoplasma capsulatum produces a spectrum of disease forms ranging from a benign self-limited illness to progressive disseminated disease with a 50 percent mortality rate. The drug of choice, amphotericin B, must be given intravenously over a prolonged course and carries a high incidence of toxicity. Thus, optimal managment of serious forms of histoplasmosis requires considerable clinical judgment.
D000208:Acute Disease; D000328:Adult; D002908:Chronic Disease; D005260:Female; D006658:Histoplasma / Q000302:isolation & purification; D006660:Histoplasmosis / Q000000981:diagnostic imaging* / Q000382:microbiology; D006801:Humans; D008297:Male; D011859:Radiography