title: Epoxide hydrase and glutathione S-transferase activities with selected alkene and adrene oxides in several marine species.
abstract: Epoxide hydrase and glutathione (GSH) S-transferase activities were measured in subcellular fractions prepared from liver or hepatopancreas and some extrahepatic organs of a number of marine species common to Maine or Florida. These activities were easily detected in the species studied. In fish, hepatic GSH S-transferase activities were normally higher than hepatic epoxide hydrase activities for the alkene oxide (styrene oxide and octene oxide) and arene oxide (benzo[a]pyrene 4,5-oxide) substrates studied, whereas in crustacea, hepatopancreas epoxide hydrase activities were higher than hepatopancreas GSH S-transferase activities with the same substrates. Extrahepatic organs from fish and crustacea usually had higher GSH S-transferase activities than epoxide hydrase activities with the alkene and arene oxide substrates. GSH S-transferase activity was also found in liver or hepatopancreas of every aquatic species studied and in a number of extrahepatic organs, when 1,2-dichloro-4-nitrobenzene or 1-chloro-2,4-dinitrobenzene served as substrate.
mesh_terms: D000475:Alkenes / Q000378:metabolism; D000818:Animals; D001580:Benzopyrenes / Q000378:metabolism; D004851:Epoxide Hydrolases / Q000378:metabolism*; D004852:Epoxy Compounds / Q000378:metabolism; D005399:Fishes / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008121:Nephropidae / Q000378:metabolism; D010179:Pancreas / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013343:Styrenes / Q000378:metabolism
chemical_list: D000475:Alkenes; D001580:Benzopyrenes; D004852:Epoxy Compounds; D013343:Styrenes; D005982:Glutathione Transferase; D004851:Epoxide Hydrolases