Hypoglycemic drugs increase liver plasma membrane microviscosity in vitro.
The effect of hypoglycemic drugs chlorpropamide and phenformin has been tested on isolated liver plasma membranes as to their microviscosity parameters. Results reported suggest that both drugs are able to increase in vitro plasma membrane microviscosity in a dose-dependent way.
D000818:Animals; D002462:Cell Membrane / Q000187:drug effects / Q000648:ultrastructure*; D002747:Chlorpropamide / Q000494:pharmacology*; D008099:Liver / Q000648:ultrastructure*; D008297:Male; D008832:Microchemistry; D010629:Phenformin / Q000494:pharmacology*; D051381:Rats; D013050:Spectrometry, Fluorescence; D014783:Viscosity
D010629:Phenformin; D002747:Chlorpropamide