Influence of chlorpromazine, diazepam, imipramine and pyrazole on ethanol-induced changes in activity of some enzymes in isolated rat liver.
Studies on the isolated rat liver showed distinct interaction of chlorpromazine, diazepam and imipramine with ethanol. Injected intraperitoneally in doses of 20 mg/kg, these drugs distinctly influenced elimination of ethanol, although not as strongly as pyrazole in vitro in the concentration of 20 mg/100 ml. On the other hand, ethanol altered the effect of these substances on the glucose curve, lactate and pyruvate levels, and activities of glutamic pyruvic and oxalacetic transaminases and aldolase.
D000818:Animals; D002746:Chlorpromazine / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D004347:Drug Interactions; D000431:Ethanol / Q000378:metabolism / Q000494:pharmacology*; D005634:Fructose-Bisphosphate Aldolase / Q000378:metabolism*; D007099:Imipramine / Q000494:pharmacology; D007773:Lactates / Q000378:metabolism; D008099:Liver / Q000201:enzymology*; D008297:Male; D011619:Psychotropic Drugs / Q000494:pharmacology*; D011720:Pyrazoles / Q000494:pharmacology*; D051381:Rats; D000637:Transaminases / Q000378:metabolism*
D007773:Lactates; D011619:Psychotropic Drugs; D011720:Pyrazoles; D000431:Ethanol; D000637:Transaminases; D005634:Fructose-Bisphosphate Aldolase; D007099:Imipramine; D003975:Diazepam; D002746:Chlorpromazine