Epidermal prostaglandins after topical application of a tumor promotor.
The topical application of the promoter, 12-O-tetradecanoyl-13-acetate, on the shaved backs of mice was attended by a striking increase in the PGE concentration within epidermis as early as 1 h later. This increase peaked at 24 h but the prostaglandin value remained elevated for at least 48 h. PGF, on the other hand, showed only a modest increase in epidermis with a maximum at 12 h. By 48 h, the PGF concentration returned to normal.
D000287:Administration, Topical; D000818:Animals; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000209:etiology; D010704:Phorbols / Q000494:pharmacology*; D011458:Prostaglandins E / Q000096:biosynthesis* / Q000502:physiology; D011460:Prostaglandins F / Q000096:biosynthesis*; D012867:Skin / Q000187:drug effects* / Q000378:metabolism; D012878:Skin Neoplasms / Q000209:etiology; D013755:Tetradecanoylphorbol Acetate / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
D010704:Phorbols; D011458:Prostaglandins E; D011460:Prostaglandins F; D013755:Tetradecanoylphorbol Acetate