Activation of lung connective tissue cells in vitro.
Guinea pig lung fibroblasts "activated" in vitro by exposure to connective tissue-activating peptides I and III, and guinea pig tissue extracts showed enhanced glycolysis and accelerated glycosaminoglycan synthesis. Formation of hyaluronic acid, and to a lesser extent, chondroitin 4/6-sulfate was stimulated by these agents.
D000818:Animals; D001681:Biological Assay; D002250:Carbon Radioisotopes; D002478:Cells, Cultured; D002809:Chondroitin Sulfates / Q000096:biosynthesis; D003238:Connective Tissue / Q000187:drug effects / Q000378:metabolism; D003239:Connective Tissue Cells; D004591:Electrophoresis, Polyacrylamide Gel; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D006019:Glycolysis / Q000187:drug effects*; D006025:Glycosaminoglycans / Q000096:biosynthesis*; D006168:Guinea Pigs; D006820:Hyaluronic Acid / Q000096:biosynthesis; D008168:Lung / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D008722:Methods; D008970:Molecular Weight; D010455:Peptides / Q000494:pharmacology*
D002250:Carbon Radioisotopes; D006025:Glycosaminoglycans; D010455:Peptides; D006820:Hyaluronic Acid; D002809:Chondroitin Sulfates