Renal papillary necrosis and pyelonephritis accompanying fenoprofen therapy.
Renal papillary necrosis occurred after fenoprofen calcium administration in a patient with systemic lupus erythematosus and urinary tract infection. Possible mechanisms of renal damage may be hypersensitivity, decreased blood flow, and decreased production of a prostaglandin E-like substance.
D005260:Female; D005279:Fenoprofen / Q000009:adverse effects*; D006801:Humans; D007681:Kidney Papillary Necrosis / Q000139:chemically induced*; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000188:drug therapy; D008875:Middle Aged; D010666:Phenylpropionates / Q000009:adverse effects*; D011704:Pyelonephritis / Q000139:chemically induced*; D014552:Urinary Tract Infections / Q000150:complications
D010666:Phenylpropionates; D005279:Fenoprofen