The effect of domperidone on pyloric activity in dog and in man.
In a study in dogs using ultrasonic transducers to measure degree of pyloric dilatation, it was found that i.v. domperidone (0.35 and 0.7 mg/kg) significantly increased the diameter of the pyloric lumen without affecting the frequency of pyloric relaxations. A subsequent study involving 59 patients referred for upper digestive tract endoscopy, confirmed this increase in diameter of the pylorus which indicates a potential use of domperidone (either i.v. or oral) in the treatment of some forms of dyspepsia characterized by delayed gastric emptying.
D000818:Animals; D000932:Antiemetics / Q000494:pharmacology*; D001562:Benzimidazoles / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D005767:Gastrointestinal Diseases / Q000503:physiopathology; D006801:Humans; D008297:Male; D009126:Muscle Relaxation / Q000187:drug effects; D010880:Piperidines / Q000494:pharmacology*; D011708:Pylorus / Q000187:drug effects* / Q000502:physiology / Q000503:physiopathology; D013997:Time Factors
D000932:Antiemetics; D001562:Benzimidazoles; D010880:Piperidines