Sodium dependence of neutral amino acid uptake into rabbit ileum.
Alanine uses two mediated pathways to enter the rabbit ileal mucosa. Present results suggest that one of them (Km = 4.1 mM) is fully dependent on sodium in the mucosal medium, while the other (Km = 91 mM) is sodium-independent. Similar results are obtained for methionine and serine. Reinterpretation of previous alanine/sodium coupling coefficients suggests that two sodium ions per alanine molecule are transported via the high affinity system.
D000409:Alanine / Q000378:metabolism; D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D007082:Ileum / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism*; D007700:Kinetics; D008715:Methionine / Q000378:metabolism; D011817:Rabbits; D012694:Serine / Q000378:metabolism; D012964:Sodium / Q000494:pharmacology*
D000596:Amino Acids; D012694:Serine; D012964:Sodium; D008715:Methionine; D000409:Alanine