H2-antagonists in the treatment of recurrent ulceration after vagotomy.
Twenty-two patients with recurrent ulceration following vagotomy with and without a drainage procedure have been treated with histamine H2-antagonists and followed for up to 3 years. Four of a group of 6 patients responded to a single therapeutic course. Ten of 16 patients assigned to long term maintenance treatment remain symptom-free. Cimetidine may be an alternative to further surgery in the treatment of some patients with recurrent ulceration after vagotomy.
D000328:Adult; D000368:Aged; D002927:Cimetidine / Q000627:therapeutic use*; D004381:Duodenal Ulcer / Q000188:drug therapy* / Q000601:surgery; D005260:Female; D006146:Guanidines / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008785:Metiamide / Q000627:therapeutic use*; D008875:Middle Aged; D012008:Recurrence; D013890:Thiourea / Q000031:analogs & derivatives*; D013997:Time Factors; D014628:Vagotomy
D006146:Guanidines; D008785:Metiamide; D002927:Cimetidine; D013890:Thiourea