Cell membrane alterations in the stria vascularis of the guinea pig after ethacrynic acid treatment studied by freeze-fracture.
A freeze-fracture examination of the stria vascularis during the first 2 h after injection of ethacrynic acid was performed. This showed a re-distribution of the particles on the membrane fracture faces of both marginal and intermediate cells. As oedematous spaces developed, particle-poor, vesicle-like structures were found associated with both cell types. The tight junctions at the apices of the marginal cells and around basal cells were unaffected.
D000818:Animals; D002462:Cell Membrane / Q000187:drug effects; D003051:Cochlea / Q000187:drug effects*; D004976:Ethacrynic Acid / Q000009:adverse effects*; D005614:Freeze Fracturing; D006168:Guinea Pigs; D013316:Stria Vascularis / Q000166:cytology / Q000187:drug effects*
D004976:Ethacrynic Acid