[Human pharmacokinetic characteristics of sulfamonomethoxine depending on the drug form].
Comparative study of sulfamonomethoxin pharmacokinetics in the man given the drug per os or parenterally in the form of methylglucaminate showed that the latter favours higher blood concentrations of the drug 12 hours following injection. Sulfamonomethoxinmeglumin is absorbed more rapidly and has a greater bioavailability. The drug is mainly excreted with urine, more than a half being excreted in an acetylated form. It is recommended that the initial and maintenance doses be not less than 1000 and 500 mg for both dosage forms respectively. The interval between sulfanilamide administrations should not exceed 24 hours.
D000328:Adult; D000368:Aged; D001702:Biopharmaceutics; D001798:Blood Proteins / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D007700:Kinetics; D008875:Middle Aged; D011485:Protein Binding / Q000187:drug effects; D013422:Sulfamonomethoxine / Q000008:administration & dosage / Q000097:blood*; D013424:Sulfanilamides / Q000097:blood*; D013607:Tablets; D013997:Time Factors
D001798:Blood Proteins; D013424:Sulfanilamides; D013607:Tablets; D013422:Sulfamonomethoxine
Osobennosti farmakokinetiki sul'famonometoksina ud cheloveka v zavisimosti ot lekarsvennoĭ formy.