[Protective action of estrogen-progestin preparations in reproductive function disorder from subtoxic doses of organophosphorus compounds].
The action of subtoxic doses of armine and nibufin administered alone and combined with steroid drugs on the rat reproductive function and uterine tissue RNA content was studied experimentally. The subtoxic doses of the drugs increased sharply the luteinizing hormone releasing factor content in the hypothalamus, as well as the synthesis and excretion of luteinizing and follicle-stimulating hormones and RNA content in the uterine tissue. Estrogen-progestin drugs, particularly infecundin, exerted a protective action in armine- and nibufin-produced abnormalities of the reproductive function.
D000818:Animals; D001138:Armin / Q000633:toxicity; D003277:Contraceptives, Oral, Combined / Q000494:pharmacology; D004347:Drug Interactions; D004967:Estrogens / Q000494:pharmacology*; D004971:Estrus / Q000187:drug effects; D005260:Female; D005333:Fetus / Q000187:drug effects; D008535:Megestrol / Q000494:pharmacology; D008656:Mestranol / Q000494:pharmacology; D009596:Nitrophenols / Q000633:toxicity; D009641:Norethynodrel / Q000494:pharmacology; D009654:Norsteroids / Q000494:pharmacology; D009943:Organophosphorus Compounds / Q000633:toxicity*; D010053:Ovary / Q000187:drug effects; D011247:Pregnancy; D045167:Progesterone Congeners / Q000494:pharmacology*; D051381:Rats; D012098:Reproduction / Q000187:drug effects*; D014599:Uterus / Q000187:drug effects
D003277:Contraceptives, Oral, Combined; D004967:Estrogens; D009596:Nitrophenols; D009654:Norsteroids; D009943:Organophosphorus Compounds; D045167:Progesterone Congeners; C008124:Infecundin; D009641:Norethynodrel; D008656:Mestranol; D008535:Megestrol; D001138:Armin
Zashchitnoe deĭstvie éstrogen-progestinovykh preparatov  pri narushenii reproduktivnoĭ funktsii subtoksicheskimi dozami fosfororganicheskikh soedineniĭ.