Systemic histoplasmosis with oesophageal obstruction due to Histoplasma granulomas. Successful treatment with rifampicin and amphotericin B.
A patient with oesophageal stenosis caused by Histoplasma granulomas is reported. He was treated with an initial combined course of intravenous amphotericin B and oral rifampicin. Complications included adrenal insufficiency, operative perforation of the oesophagus, amphotericin nephrotoxicity and tuberculosis. The histoplasmosis has not recurred for over 3 years.
D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004940:Esophageal Stenosis / Q000209:etiology*; D006099:Granuloma / Q000209:etiology; D006660:Histoplasmosis / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008297:Male; D012293:Rifampin / Q000627:therapeutic use*
D000666:Amphotericin B; D012293:Rifampin