Increased serum concentrations of lactic, pyruvic and uric acid and bilibubin after postoperative xylitol infusion.
Xylitol has been suggested as a more advantageous calory source for intravenous administration than glucose in certain clinical situation, but the general suitability of intravenous xylitol infusion has not been confirmed. Thirty-middle-aged women were infused with 100 g of xylitol as postoperative fluid therapy after gynaecological laparotomy and general anaesthesia. Another 10 women received 50 g of glucose in a similar manner and served as a reference group. Infusion of xylitol both at the rate of 0.25 g/kg/h (1000 ml 10% xylitol in approx. 8 h) and 0.5 g/kg/h (1000 ml 10% xylitol in approx. 4 h) caused a distinct increase in the serum concentrations of lactic acid, pyruvic acid, and uric acid; such an increase was not seen with glucose infusion. The faster infusion of xylitol also distinctly increased serum bilirubin concentrations. Because of the possibility of lactic acidosis and urate deposits in kidneys, infusion of 100 g or more of xylitol at a rate of 0.25 g/kg/h or faster is not safe for postoperative fluid therapy in routine clinical work.
D000768:Anesthesia, General; D001663:Bilirubin / Q000097:blood*; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D007773:Lactates / Q000097:blood*; D008875:Middle Aged; D010313:Partial Pressure; D011182:Postoperative Care; D011773:Pyruvates / Q000097:blood*; D013997:Time Factors; D014527:Uric Acid / Q000097:blood*; D014993:Xylitol / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
D007773:Lactates; D011773:Pyruvates; D014527:Uric Acid; D001663:Bilirubin; D014993:Xylitol