title: The effect of the composition of food on the absorption of sulfameter.
abstract: The present investigation is concerned with the influence of the composition of food on the absorption of sulfameter. Six physically healthy patients each were given 2 g of sulfameter simultaneously with a high lipid, high protein and high carbohydrate test meal. This experiment was designed as a threefold crossover study, and there was a randomized assignment of patients to the different conditions. The results show that sulfameter is significantly better absorbed when administered with a high lipid meal than when given with a high protein or high carbohydrate meal, demonstrated by the areas under the serum concentration curves (AUC), by the peak serum concentration and by the cumulative renal excretion.
mesh_terms: D000328:Adult; D004032:Diet; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004044:Dietary Proteins; D006801:Humans; D007408:Intestinal Absorption; D013417:Sulfameter / Q000097:blood / Q000378:metabolism* / Q000652:urine; D013424:Sulfanilamides / Q000378:metabolism*
chemical_list: D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004044:Dietary Proteins; D013424:Sulfanilamides; D013417:Sulfameter