Re-examination of effect of paracetamol on serum uric acid measured by phosphotungstic acid reduction.
The drug paracetamol (N-acetyl-p-aminophenol; acetaminophen) caused a spurious increase in serum uric acid measured by phosphotungstic acid reduction methods. However, the increase was less than 0.12 mmol/1 at plasma levels of paracetamol found in overdosage (40 mg/100 ml) and was small at therapeutic concentrations (less than 4 mg/100 ml). It is concluded that few patients with joint pain who have taken paracetamol paracetamol as an analgesic will have clinically misleading values for serum uric acid.
D000082:Acetaminophen / Q000097:blood / Q000494:pharmacology*; D005189:False Positive Reactions; D006073:Gout / Q000097:blood / Q000175:diagnosis; D006801:Humans; D008722:Methods; D010084:Oxidation-Reduction; D010772:Phosphotungstic Acid; D019966:Substance-Related Disorders; D014527:Uric Acid / Q000097:blood*
D010772:Phosphotungstic Acid; D014527:Uric Acid; D000082:Acetaminophen