Determination of viloxazine in plasma by GLC.
1 A gas chromatographic procedure for the determination of viloxazine in therapeutic concentrations in human plasma, with use of a flame ionization detector, is described. 2 The drug is extracted at pH 12 into hexane, back extracted into HCl, re-extracted into hexane after alkalinization of the HCl and derivatized with acetic anhydride. 3 An imipramine-butriptyline mixture is used as an internal standard. The coefficients of variation for a concentration of 0.75 microgram/ml are 9.4% and 13.1% for within day and day to day precision respectively. For a 1.75 micrograms/ml solution the within day precision was 5.7%. 4 The method has been applied to a patient receiving 300 mg/day viloxazine treatment.
D000107:Acetylation; D002849:Chromatography, Gas; D006801:Humans; D008722:Methods; D009025:Morpholines / Q000097:blood*; D013997:Time Factors; D014745:Viloxazine / Q000097:blood* / Q000627:therapeutic use
D009025:Morpholines; D014745:Viloxazine