Fibroblast function and the maintenance of the aortic-valve matrix.
The long-term behaviour of the aortic-valve allograft seems to be dependent on the maintenance of its matrix. Protein and collagen synthesis was studied in rat aortic-valves. Quantitative and qualitative methods proved the production of at least two protein pools. One protein pool is localised intracellularily with a 'turn-over' time of about 2 weeks, and a second pool is localised extracellularly with a 'turn-over' time of at least 8 weeks. The latter protein pool mainly consists of collagen.
D000818:Animals; D001021:Aortic Valve / Q000378:metabolism*; D002356:Cartilage / Q000378:metabolism; D003094:Collagen / Q000096:biosynthesis*; D005347:Fibroblasts / Q000378:metabolism; D008297:Male; D008715:Methionine / Q000378:metabolism; D011392:Proline / Q000378:metabolism; D014176:Protein Biosynthesis; D051381:Rats
D003094:Collagen; D011392:Proline; D008715:Methionine