A three-dimensional study of organelle interrelationships in regenerating rat liver. 4. Multivesicular bodies.
Double-membraned plasma-membrane-loops are formed from the plasma membrane and released into the cytoplasm. The vesiculation of mainly their inner membrane may transform them into MVB. The so-formed internal vesicles contain cytosol. In many MVB the surface of all their internal vesicles to gether corresponds well with the surface of their bordering membrane. This correlation may be the result of a dynamic equilibrium whereby degradation (and partial recyclage) of internal vesicles is compensated for by the formation of new internal vesicles. When this equilibrium becomes disturbed, MVB may show much less internal vesicles. Such 'depleted' MVB are often producing peribiliary vesicles and may themselves transform into lacunate emptying into the bile canaliculi.
D000818:Animals; D002462:Cell Membrane / Q000648:ultrastructure*; D006056:Golgi Apparatus / Q000648:ultrastructure; D007425:Intracellular Membranes / Q000648:ultrastructure; D008099:Liver / Q000648:ultrastructure*; D008115:Liver Regeneration; D008854:Microscopy, Electron; D051381:Rats