title: Dietary fibre and colonic neoplasia.
abstract: Dietary plant fibre, or plantix, is thought to play a significant role in the pathogenesis of colon cancer in humans. It is a complex polymeric substance that has several distinct components resistant to hydrolysis by the digestive enzymes of humans. These components include cellulose, hemicelluloses, pectins, lignin, gums, mucilages and, in certain instances, algal polysaccharides. These polymers have different physicochemical properties, and recent evidence from experimental studies in animals treated with carcinogens suggests that some may exert protective effects in the intestine and others may enhance colon carcinogenesis. This review synthesizes information on the chemical composition, methods of analysis and physicochemical properties of dietary plant fibre and reviews available studies examining the role of fibre in colonic neoplasia in animals and humans.
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism; D002482:Cellulose / Q000378:metabolism; D003110:Colonic Neoplasms / Q000517:prevention & control*; D004043:Dietary Fiber / Q000378:metabolism; D004127:Dimethylhydrazines / Q000378:metabolism; D056890:Eukaryota; D006801:Humans; D008031:Lignin / Q000378:metabolism; D010368:Pectins / Q000378:metabolism; D011108:Polymers; D011134:Polysaccharides / Q000378:metabolism; D051381:Rats
chemical_list: D001647:Bile Acids and Salts; D004043:Dietary Fiber; D004127:Dimethylhydrazines; D011108:Polymers; D011134:Polysaccharides; D010368:Pectins; D002482:Cellulose; D008031:Lignin