Disseminated Mycobacterium chelonei infection: response to sulfonamides.
A disseminated infection due to Mycobacterium chelonei occurred in a hemodialysis patient after rejection of his second renal transplant. Painful subcutaneous nodules and abscesses were found on both legs. Therapy with sulfisoxaxole and kanamycin produced a prompt response twice, as did sulfisoxazole alone on 2 additional occasions, despite resistance in vitro to both drugs. Clinical relapses occurred 3 times when administration of sulfisoxazole was discontinued.
D000284:Administration, Oral; D000328:Adult; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007273:Injections, Intramuscular; D007612:Kanamycin / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D008826:Microbial Sensitivity Tests; D009164:Mycobacterium Infections / Q000188:drug therapy*; D009165:Mycobacterium Infections, Nontuberculous / Q000188:drug therapy*; D009170:Nontuberculous Mycobacteria / Q000187:drug effects; D012874:Skin Diseases, Infectious / Q000188:drug therapy*; D013420:Sulfamethoxazole / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D013444:Sulfisoxazole / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D014295:Trimethoprim / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*
D000995:Antitubercular Agents; D007612:Kanamycin; D013444:Sulfisoxazole; D014295:Trimethoprim; D013420:Sulfamethoxazole