Reappraisal of the secretory potency and disappearance rate of pure human minigastrin.
The secretory potency and disappearance rates of pure synthetic human non-sulphated minigastrin (HG-14-I) and pure natural human non-sulphated heptadecapeptide (HG-17-I) were compared in five dogs with gastric fistulas and Heidenhain pouches. Intravenous infusion of equimolar doses of the two gastrins produced equimolar increases over basal of serum immunoreactive gastrin and no statistically significant differences in acid output. Also HG-14-I and HG-17-I did not differ significantly in half-times for disappearance, clearance rates, calculated volumes of distribution, or mean plateau serum levels.
D000818:Animals; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005747:Gastric Fistula / Q000503:physiopathology; D005750:Gastric Juice / Q000378:metabolism*; D005755:Gastrins / Q000097:blood / Q000494:pharmacology*; D006728:Hormones / Q000097:blood / Q000494:pharmacology; D008657:Metabolic Clearance Rate; D012636:Secretory Rate / Q000187:drug effects
D005755:Gastrins; D006728:Hormones