[Role of the GABA-ergic systems of the brain in manifesting the activating effect of diazepam].
It was shown in experiments on rats that the selective blocker of GABA receptors bicuculline (2 mg/kg) does not decrease the activating effect of diazepam as to the reaction of self-stimulation. The GABA-mimetic muscimol (0.5 and 1 mg/kg) had no effect on self-stimulation rate, while in the dose of 2 mg/kg causing behavioral changes produced a powerful decrease in it (by 93.3%). During the combined administration of diazepam and muscimol (1 mg/kg and 0.5 mg/kg, respectively) no potentiation of diazepam effect was observed. It is suggested that diazepam-induced facilitation of the reaction of self-stimulation is not due to the alteration in the activity of GABA-ergic processes.
D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D001921:Brain / Q000187:drug effects*; D003975:Diazepam / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D009043:Motor Activity / Q000187:drug effects; D009118:Muscimol / Q000494:pharmacology; D051381:Rats; D011955:Receptors, Drug / Q000187:drug effects*; D012653:Self Stimulation / Q000187:drug effects; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D011955:Receptors, Drug; D009118:Muscimol; D005680:gamma-Aminobutyric Acid; D003975:Diazepam; D001640:Bicuculline
Rol'GAMK-ergicheskikh sistem mozga v proiavlenii aktiviruiushchego éffekta diazepama.