title: [Postoperative haemodynamic evaluation of myocardial protection by physicochemical cardioplegia. Hyperkaliemic, hyperosmolar and acid solution at 4 degrees C (author's transl)].
abstract: Myocardial protection by a combination of cardiac hypothermia and chemical cardioplegia (high concentration of K+ and Mg++, hyperosmolarity, acid pH), was studied during 20 valve replacements. Essentially assessed on the basis of repeated measurements of postoperative cardiac output, the results were compared with those obtained previously using local hypothermia only (20 patients) and hypothermic cardioplegia using Ringer Lactate (20 patients). Analysis of haemodynamic data, which thus involved 60 patients, indicated the superiority of physicochemical cardioplegia, and this for clamping periods of up to 2 hours, but also showed the desirability of changes in the protection protocol during the ischaemia phase and during reperfusion which might improve the results.
mesh_terms: D002302:Cardiac Output; D005260:Female; D006324:Heart Arrest, Induced / Q000379:methods*; D006351:Heart Valves / Q000601:surgery*; D006439:Hemodynamics; D006801:Humans; D006947:Hyperkalemia; D007036:Hypothermia, Induced; D008274:Magnesium / Q000097:blood; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D011182:Postoperative Care / Q000379:methods*
chemical_list: D008274:Magnesium
vernacular_title: Evaluation hémodynamique post-opératoire de la protection myocardique par cardioplégie physico-chimique. Solution à 4 degrees C, hyperkaliémique, hyperosmolaire et acide.