[Role of changes in rheological properties of blood in the pathogenesis of disorders of cardiac rhythm and conductivity].
Changes were induced in the rheological blood properties and hemostasis in 40 albino rats by intracardiac injection of high-molecular dextran, arvin, and ethanol. Ten rats received dipyridamole. Changes caused by these agents in erythrocyte deformability were determined by the rheoscopical method. Their effect on the threshold of ventricular fibrillation induced by electric current was also determined. Dextran and arvin reduced erythrocyte deformability and the threshold of ventricular fibrillation to half the initial values. An increase in the ventricular fibrillation threshold due to the effect of dipyridamole was attended by improvement in erythrocyte deformability. Ethanol reduced the threshold of ventricular fibrillation and caused disorders of cardiac atrioventricular conduction. Intravenous infusion of high-molecular dextran and arvin caused various disorders of cardiac rhythm and atrioventricular conduction in 11 out of 12 rabbits. Preliminary administration of rheopolyglucin in 3 rabbits prevented the development of cardiac arrhythmias on injection of dextran and arvin. The authors believe that deterioration of the blood rheological properties is one of the pathogenetic mechanisms in the development of disorders of cardiac rhythm and conduction.
D000818:Animals; D001809:Blood Viscosity / Q000187:drug effects*; D004176:Dipyridamole / Q000037:antagonists & inhibitors; D004336:Drug Antagonism; D004903:Erythrocyte Aggregation / Q000187:drug effects*; D004913:Erythrocytes, Abnormal / Q000187:drug effects; D000431:Ethanol / Q000009:adverse effects / Q000037:antagonists & inhibitors; D006327:Heart Block / Q000139:chemically induced*; D011817:Rabbits; D051381:Rats; D014693:Ventricular Fibrillation / Q000139:chemically induced*
D000431:Ethanol; D004176:Dipyridamole
Rol' izmeneniĭ reologicheskikh svoĭstv krovi v patogeneze narusheniĭ ritma i provodimosti serdtsa.