Effects of the cyanine dye 3,3'-dipropylthiocarbocyanine on mitochondrial energy conservation.
Mitochondrial respiration and oxidative phosphorylation were inhibited by the membrane potential probe 3,3'-dipropylthiocarbocyanine [diS-C3-(5)]. Evidence is presented that suggests that the dye acts as both an inhibitor of electron transport and an uncoupler of oxidative phosphorylation.
D000818:Animals; D001937:Brassica / Q000378:metabolism; D002232:Carbocyanines / Q000494:pharmacology*; D004396:Coloring Agents / Q000494:pharmacology*; D004579:Electron Transport / Q000187:drug effects; D066298:In Vitro Techniques; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D011804:Quinolines / Q000494:pharmacology*; D051381:Rats
D002232:Carbocyanines; D004396:Coloring Agents; D011804:Quinolines