Role of homocytotropic antibodies in pathogenesis of gastric ulcer.
Praomys (Mastomys) natalensis were sensitised by peritoneal injection of ovalbumin mixed with aluminium hydroxide. The animals developed homocytotoropic IgE and IgG 1 antibodies. When presensitised animals were challenged with ovalbumin in the gastric wall, a gastric ulcer appeared. This ulceration, induced by an immunological release of histamine, could be inhibited by the administration of disodium cromoglycate. The present model is useful for producing a gastric ulcer in a determined site. It supports the theory of a possible allergic component in the pathogenesis of the human disease.
D000818:Animals; D000906:Antibodies; D000917:Antibody Formation; D000941:Antigens; D005260:Female; D005753:Gastric Mucosa / Q000276:immunology; D006968:Hypersensitivity, Delayed; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D008407:Mast Cells / Q000276:immunology; D010047:Ovalbumin / Q000008:administration & dosage; D011935:Reagins; D012377:Rodentia; D013276:Stomach Ulcer / Q000209:etiology / Q000276:immunology*
D000906:Antibodies; D000941:Antigens; D007075:Immunoglobulin M; D011935:Reagins; D010047:Ovalbumin