title: Characterization of endogenous folate and incorporation of labelled folates into the brain of the South African fruit bat.
abstract: Folate in the brain of the South African fruit bat consists of 10-formyltetrahydropteroyglutamic acid and the tri-, tetra- and penta- forms of 5-methyltetrahydropteroylglutamic acid. Following parenteral injection, only 5-[3H]-methyltetrahydropteroylglutamic acid was taken up by the brain, but none of a dose of 14C-labelled tetrahydropteroylglutamic acid was detectable. Only trace smounts of the 5-methyltetrahydropteroylglutamic acid were converted into the formyl compounds and a small amount of methyltetrahydropteroyltriglutamic acid appeared after 96 h. There was no significant difference in vitamin B-12-deficient animals.
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D002685:Chiroptera / Q000378:metabolism*; D005492:Folic Acid / Q000031:analogs & derivatives*; D011624:Pteroylpolyglutamic Acids / Q000378:metabolism*; D013763:Tetrahydrofolates / Q000378:metabolism; D014806:Vitamin B 12 Deficiency / Q000378:metabolism
chemical_list: D011624:Pteroylpolyglutamic Acids; D013763:Tetrahydrofolates; D005492:Folic Acid