Action of glomerulopressin on smooth muscle contraction, probably mediated by the release of prostaglandins.
The effect of glomerulopressin on the increase of the contractile tension developed by isolated strips of stomach fundus, duodenum and bladder of rats, was investigated. Glomerulopressin is a glucuronide whose contractile inducing effect was destroyed by beta-glucuronidase. It was observed that glomerulopressin increases the contractile tension of these tissues, and that this action was not blocked by atropine, cyproheptadine, tranylcypromine, but was inhibited by indomethacin, suggesting that the effect of glomerulopressin action was mediated by prostaglandin release.
D000818:Animals; D004285:Dogs; D004347:Drug Interactions; D004386:Duodenum / Q000187:drug effects; D005965:Glucuronates / Q000494:pharmacology*; D006728:Hormones / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects* / Q000378:metabolism; D011453:Prostaglandins / Q000378:metabolism*; D051381:Rats; D013270:Stomach / Q000187:drug effects; D014191:Tranylcypromine / Q000494:pharmacology; D001743:Urinary Bladder / Q000187:drug effects
D005965:Glucuronates; D006728:Hormones; D011453:Prostaglandins; D014191:Tranylcypromine