[Effect of hydrocortisone on 14C-lysine incorporation into the nuclear and mitochondrial proteins of the rat thymus at different times of day].
The data on 14C-lysine incorporation have shown that normally there exists 12-hour periodicity of intensifying the synthesis of nuclear and mitochondrial proteins by the rat thymus, that correlates with similar changes in the DNA synthesis and in the mitotic rate. Administration of hydrocortisone during varying time of the day induces the synthesis of non-histone proteins of chromatin primarily in non-proliferating populations of thymus lymphocytes, the synthesis of histones being induced in proliferating ones.
D000818:Animals; D002250:Carbon Radioisotopes; D002467:Cell Nucleus / Q000187:drug effects; D002940:Circadian Rhythm / Q000187:drug effects*; D004247:DNA / Q000096:biosynthesis; D006657:Histones / Q000096:biosynthesis; D006854:Hydrocortisone / Q000494:pharmacology*; D008239:Lysine / Q000378:metabolism*; D008297:Male; D008928:Mitochondria / Q000187:drug effects; D014176:Protein Biosynthesis; D051381:Rats; D013936:Thymidine / Q000378:metabolism; D013950:Thymus Gland / Q000187:drug effects*; D014316:Tritium
D002250:Carbon Radioisotopes; D006657:Histones; D014316:Tritium; D004247:DNA; D008239:Lysine; D013936:Thymidine; D006854:Hydrocortisone
Vliianie gidrokortizona na vkliuchenie 14C-lizina v iadernye i mitokhondrial'nye belki timusa krys v raznoe vremia sutok.