[Structure of the genomes of recombinant strains of influenza A viruses with various antigenic and biological properties].
Genomes of influenza A/WSN/33, A/Singapore/57 and recombinant X-7 and X-9 viruses were studied by the method of molecular hybridization followed by electrophoretic separation of RNA-duplexes in polyacrylamide gel. The genome of the recombinant X-7 influenza virus strain was found to contain fragments V and VII of RNA corresponding to fragments of A/Singapore/57 RNA, whereas fragments III, IV, and VIII were derived from influenza A/WSN/33 virus. Recombinant X-9 had fragments III, IV, and VII of RNA similar to those of A/Singapore/57, and fragments V,VIII of RNA derived from influenza A/WSN/33 virus. Resistance to rimantadine in influenza viruses correlated in X-7 and X-9 recombinants to the strain appurtenance of fragment VIII.
D000218:Adamantane / Q000031:analogs & derivatives / Q000494:pharmacology; D000954:Antigens, Surface / Q000235:genetics; D000956:Antigens, Viral / Q000235:genetics*; D004352:Drug Resistance, Microbial; D005814:Genes, Viral; D009980:Influenza A virus / Q000187:drug effects / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D011995:Recombination, Genetic; D014779:Virus Replication / Q000187:drug effects
D000954:Antigens, Surface; D000956:Antigens, Viral; D000218:Adamantane
Struktura genomov rekombinantnykh shtammov virusov grippa A s razlichnymi antigennymi i biologicheskimi svoĭstvami.