Relation of precurarization to suxamethonium to provide ease of intubation and to prevent post-suxamethonium muscle pains.
Tubocurarine 0.05 and 0.07 mg.kg-1, gallamine 0.1 and 0.2 mg.kg-1 and pancuronium 0.01 and 0.02 mg.kg-1 given three minutes before suxamethonium 1.0, 1.5 and 2 mg.kg-1 in groups of 10 patients each (total 210 patients) to compare ease of tracheal intubation and incidence of post-suxamethonium muscle pain. These were compared with a control group of suxamethonium 1.0, 1.5 and 2 mg.kg-1 given alone after thiopentone 5 mg.kg-1. On analysis, tubocurarine 0.07 mg.kg-1 and suxamethonium 2 mg.kg-1 was the ideal combination with the best intubation conditions and the lowest incidence of post-suxamethonium muscle pains. The second best combination was gallamine 0.2 mg.kg-1 and suxamethonium 2 mg.kg-1. Pancuronium 0.01 mg.kg-1 and 0.02 mg.kg-1 in combination with suxamethonium 2 mg.kg-1 were satisfactory, although less efficient than the combination with either tubocurarine or gallamine.
D000328:Adult; D001835:Body Weight; D005207:Fasciculation / Q000139:chemically induced; D005703:Gallamine Triethiodide / Q000009:adverse effects; D006801:Humans; D007442:Intubation, Intratracheal; D009132:Muscles; D010149:Postoperative Pain / Q000517:prevention & control*; D010197:Pancuronium / Q000009:adverse effects; D013390:Succinylcholine / Q000008:administration & dosage* / Q000009:adverse effects; D014403:Tubocurarine / Q000009:adverse effects
D013390:Succinylcholine; D010197:Pancuronium; D005703:Gallamine Triethiodide; D014403:Tubocurarine