title: Synthesis of human proinsulin sequence 71-86, II: Improved synthesis of the fragment.
abstract: An improved synthesis of a fully protected hexadecapeptide Bpoc-Cys(Trt)-Cys-(Trt)-Thr(But)-Ser(But)-Ile-Cys(Trt)-Ser(But)-Leu-Tyr(But)-Gln-Leu-Glu(OBut)-Asn-Tyr(But)-Cys(Trt)-Asn-OBut, which corresponds to the amino acid sequence 71-86 of human proinsulin, is described. The final product was obtained by the condensation of three fragments 71-74, 75-77 and 78-86.
mesh_terms: D000595:Amino Acid Sequence; D006801:Humans; D007202:Indicators and Reagents; D008722:Methods; D010455:Peptides / Q000138:chemical synthesis*; D011384:Proinsulin / Q000138:chemical synthesis*; D014320:Triphenylmethyl Compounds
chemical_list: D007202:Indicators and Reagents; D010455:Peptides; D014320:Triphenylmethyl Compounds; D011384:Proinsulin