title: Gentamicin in the treatment of lower genital tract infections: level of the drug in menses, cervical mucus and vaginal fluid.
abstract: The concentration of gentamicin in serum, menses, cervical mucus and vaginal fluid of 39 women under treatment with this antibiotic (80 mg every 8 hr i. m.) was tested by the agar diffusion method. The levels of the drug in the serum varied from 1.88-5.41 micrograms/ml with a peak one hour after the last dosage. In the menses the levels ranged from 2.06-5.87 micrograms/ml with a peak also one hour after the last dosage. The concentration of gentamicin in the cervical mucus and vaginal fluid varied from 0.67-5.14 micrograms/ml and 0.63-6.43 micrograms/ml with a peak three hours after the last administration of the drug. Results are briefly discussed.
mesh_terms: D001424:Bacterial Infections / Q000188:drug therapy; D001826:Body Fluids / Q000032:analysis; D002582:Cervix Mucus / Q000032:analysis; D005260:Female; D005831:Genital Diseases, Female / Q000188:drug therapy*; D005839:Gentamicins / Q000097:blood / Q000627:therapeutic use*; D006801:Humans; D008598:Menstruation; D014621:Vagina
chemical_list: D005839:Gentamicins