Oestrogenic effects of catechol oestrogens on secretion of prolactin by the pituitary gland and synthesis of DNA by the mammary gland in ovariectomized rats.
The effects of 2-hydroxyoestradiol-17 beta and 2-hydroxyoestriol (2OH-OE3) on levels of serum prolactin, DNA synthesis by the mammary gland and the weight of the uterus were examined in ovariectomized Sprague-Dawley rats. 2-Hydroxyoestradiol-17 beta had a potent oestrogenic activity in stimulating the secretion of prolactin by the pituitary gland, the synthesis of DNA by the mammary gland and in increasing the weight of the uterus. On the other hand, 2OH-OE3 increased the weight of the uterus only.
D000818:Animals; D002369:Castration; D004247:DNA / Q000096:biosynthesis*; D004958:Estradiol / Q000031:analogs & derivatives* / Q000494:pharmacology; D004964:Estriol / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D008321:Mammary Glands, Animal / Q000187:drug effects / Q000378:metabolism*; D009929:Organ Size / Q000187:drug effects; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism*; D011388:Prolactin / Q000097:blood / Q000378:metabolism*; D051381:Rats; D012636:Secretory Rate / Q000187:drug effects; D014599:Uterus / Q000187:drug effects
D004958:Estradiol; D011388:Prolactin; D004247:DNA; D004964:Estriol