The effect of intracerebroventricular administration of methionine-enkephalin on the stress-induced secretion of corticosterone in mice.
Ether stress or intracerebroventricular (i.c.v.) administration of saline, met-enkephalin, or naltrexone raised plasma corticosterone levels in mice. The response to ether stress was abolished by a preceding ether stress or by pretreatment with i.c.v. saline or naltrexone. However, following i.c.v. met-enkephalin, plasma corticosterone was significantly elevated by ether stress, the effect being blocked by simultaneous injection of met-enkephalin and naltrexone. Met-enkephalin appears to prevent fast-feedback inhibition of the hypothalamus-pituitary-adrenal system.
D000818:Animals; D003345:Corticosterone / Q000097:blood*; D004723:Endorphins / Q000494:pharmacology*; D004745:Enkephalins / Q000494:pharmacology*; D004986:Ether; D007700:Kinetics; D008297:Male; D051379:Mice; D009271:Naltrexone / Q000494:pharmacology; D013312:Stress, Physiological / Q000097:blood*
D004723:Endorphins; D004745:Enkephalins; D004986:Ether; D009271:Naltrexone; D003345:Corticosterone