Change in oscillatory potential by thioridazine.
Toxic effects on the retina by oral administration of thioridazine was investigated by electroretinography (ERG) using male Wistar rats. An obvious reduction followed by a disappearance in the O2 component of the oscillatory potentials of the ERG was seen in a dose-dependent manner. The minimum dosage given to produce the above change was 3 mg/kg/day for 7 days' administration. This change seemed to be permanent, whereas a and b waves as well as other oscillatory potentials, e.g., O1, O3, were normal throughout the experiment. The significance of the data is discussed.
D000200:Action Potentials / Q000187:drug effects; D000284:Administration, Oral; D000818:Animals; D004596:Electroretinography; D008297:Male; D051381:Rats; D012160:Retina / Q000187:drug effects*; D013881:Thioridazine / Q000008:administration & dosage / Q000633:toxicity*
D013881:Thioridazine