Plasma concentrations of propranolol and 4-hydroxypropranolol during chronic oral propranolol therapy.
1 The plasma levels of propranolol and 4-hydroxypropranolol have been measured in 17 hypertensive patients receiving chronic oral therapy with propranolol. 2 The range of plasma propranolol concentrations was from 5.3 to 300 ng/ml, and that of 4-hydroxypropranolol was from 2.1 to 36.0 ng/ml. 3 The mean (+/- s.d.) plasma concentration ratio of 4-hydroxypropranolol to propranolol was 0.130 (+/- 0.005); however, a very wide range was observed with individual values ranging from 0.057 to 0.241. 4 A statistically significant correlation was observed between the plasma concentration of 4-hydroxypropranolol and that of propranolol. 5 Propranolol and 4-hydroxypropranolol plasma concentrations were each significantly, but poorly, correlated with daily propranolol dose. 6 The clinical significance of the results has been discussed.
D000328:Adult; D000368:Aged; D001711:Biotransformation; D005260:Female; D006801:Humans; D006900:Hydroxylation; D006973:Hypertension / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D011433:Propranolol / Q000097:blood* / Q000627:therapeutic use; D013997:Time Factors
D011433:Propranolol