Distribution of misonidazole in human tumours and normal tissues.
Levels of misonidazole in human tumours, normal tissues and blood have been measured in patients given a 1g oral dose of drug before surgery or biopsy. The results show that 50--70% of the blood level was found in a wide range of tumours and that similar levels were found in adjacent normal tissues. Good penetration of drug was achieved within tumours, and up to 90--100% of the blood level was found in the necrotic cyst fluid at the centre of some tumours. CSF studies showed free diffusion into the CNS, which was confirmed by finding 50--70% of the blood level within brain tumours. A delay of passage of drugs into the CSF was noted, which was not found for drug diffusion into bile and saliva.
D001932:Brain Neoplasms / Q000378:metabolism; D001943:Breast Neoplasms / Q000378:metabolism; D005260:Female; D005833:Genital Neoplasms, Female / Q000378:metabolism; D006801:Humans; D008297:Male; D008920:Misonidazole / Q000097:blood / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism*; D009593:Nitroimidazoles / Q000378:metabolism*; D013959:Thyroid Diseases / Q000378:metabolism; D014018:Tissue Distribution; D001749:Urinary Bladder Neoplasms / Q000378:metabolism
D009593:Nitroimidazoles; D008920:Misonidazole