Psychopharmacological study with K 8409, a 1H-naphtho[2,1-b]pyran 3-dialkylamino substituted derivative.
A 1H-naphtho[2,1-b]pyran derivative (K 8409) has undergone pharmacological investigation for psychotropic activity. The results show potential antidepressant action quantitatively similar to that of imipramine and amitriptyline, but due rather to MAO inhibition than to imipramine-like activity; interestingly enough, anti-MAO activity was particularly selective for the serotonin-converting enzyme, both centrally and peripherally. The outcome of the other tests suggests that the incidence of untoward effects is likely to be limited.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects; D004298:Dopamine / Q000378:metabolism; D051379:Mice; D008996:Monoamine Oxidase Inhibitors / Q000378:metabolism; D010095:Oxotremorine / Q000037:antagonists & inhibitors; D010276:Parasympatholytics / Q000494:pharmacology; D011619:Psychotropic Drugs / Q000494:pharmacology*; D011714:Pyrans / Q000494:pharmacology*; D011753:Pyrones / Q000494:pharmacology*; D051381:Rats; D012110:Reserpine / Q000037:antagonists & inhibitors; D012701:Serotonin / Q000378:metabolism; D012890:Sleep / Q000187:drug effects; D013574:Synaptosomes / Q000187:drug effects
D008996:Monoamine Oxidase Inhibitors; D010276:Parasympatholytics; D011619:Psychotropic Drugs; D011714:Pyrans; D011753:Pyrones; D012701:Serotonin; D010095:Oxotremorine; D012110:Reserpine; D004298:Dopamine