The role of sialic acid in 5-HT binding to synaptic membranes.
The high affinity binding of [14C]5-HT to nerve ending membranes isolated from rat brain is not affected by neuraminidase treatment. The specificity of ligand receptor interaction was demonstrated by displacement studies with tryptamine derivatives, noradrenaline, and acetylcholine.
D000818:Animals; D001667:Binding, Competitive; D001921:Brain / Q000378:metabolism; D007700:Kinetics; D009439:Neuraminidase; D009474:Neurons / Q000378:metabolism; D051381:Rats; D011985:Receptors, Serotonin / Q000378:metabolism*; D012701:Serotonin / Q000031:analogs & derivatives / Q000378:metabolism*; D012794:Sialic Acids / Q000502:physiology*; D013329:Structure-Activity Relationship; D013570:Synaptic Membranes / Q000378:metabolism*
D011985:Receptors, Serotonin; D012794:Sialic Acids; D012701:Serotonin; D009439:Neuraminidase