Clindamycin excretion in the pancreatic fluid of dogs.
Clindamycin phosphate in dosage of 15 mg/kg was administered intravenously to dogs. Serum and pancreatic juice clindamycin concentrations were assayed. Pancreatic juice clindamycin concentrations varied between 1.32--5.5 micrograms/ml. Clindamycin was still detectable in the pancreatic juice 4 1/2 h after its administration. Clindamycin, in combination with other antimicrobials, may be potentially effective in the prophylaxis and therapy of some of the infectious complications associated with pancreatitis.
D000818:Animals; D002981:Clindamycin / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D004285:Dogs; D007263:Infusions, Parenteral; D010179:Pancreas / Q000378:metabolism*; D010189:Pancreatic Juice / Q000032:analysis; D013997:Time Factors
D002981:Clindamycin