title: [Effect of radioactive iodine therapy and surgical treatment of thyrotoxicosis on the blood level of thyrotropin].
abstract: The radioimmunological method was applied to the study of the thyrotropic hormone (TTH) content in the blood of 308 patients with thyrotoxicosis at various stages of therapy with radioactive iodine and surgical treatment. After 131I treatment and elimination of the thyrotoxicosis symptoms TTH rose 1 to 2 years and 5 to 10 years after the onset of remission, this being regarded as an adaptive response to the changing thyroid activity. The hypothalamo-hypophysio-thyroid interaction was restored after the successful 131I therapy. However, surgical treatment of thyrothoxicosis did not lead to restoration of such interaction for 5 years--no changes of the TTH level followed either the "primary" subtotal thyroidectomy or repeated operation for the relapsing form of the disease.
mesh_terms: D005500:Follow-Up Studies; D006801:Humans; D006980:Hyperthyroidism / Q000503:physiopathology / Q000628:therapy*; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D013961:Thyroid Gland / Q000503:physiopathology; D013965:Thyroidectomy; D013972:Thyrotropin / Q000097:blood*
chemical_list: D007457:Iodine Radioisotopes; D013972:Thyrotropin
vernacular_title: Vliianie terapii radioaktivnym ĭodom i khirurgicheskogo lecheniia tireotoksikoza na uroven tireotropnogo gormona gipofiza v krovi.