Peripheral blood lymphocyte subpopulations in multiple myeloma.
Antisera raised against idiotypic determinants of myeloma proteins and macroglobulins have been used to differentiate peripheral blood lymphocytes populations from individual patients. I.D.-positive lymphocytes not resembling plasma cells have been regularly found in peripheral blood in these diseases. This lymphocyte population is heterogeneous with respect to non-tumor-specific surface markers, such as SRBC-, Fc- and C-receptors. Tumor specific idiotypic determinants will thus allow a more correct recognition of the total tumor cell compartment in these diseases.
D000818:Animals; D000961:Antilymphocyte Serum / Q000494:pharmacology; D001665:Binding Sites; D002965:Classification; D003165:Complement System Proteins; D004912:Erythrocytes / Q000276:immunology; D006801:Humans; D007141:Immunoglobulin Fc Fragments; D007130:Immunoglobulin Idiotypes; D008214:Lymphocytes; D009101:Multiple Myeloma / Q000276:immunology*; D011817:Rabbits; D011947:Receptors, Antigen, B-Cell
D000961:Antilymphocyte Serum; D007141:Immunoglobulin Fc Fragments; D007130:Immunoglobulin Idiotypes; D011947:Receptors, Antigen, B-Cell; D003165:Complement System Proteins