Central action of new imido derivatives of succinic acid.
New imido derivatives of succinic acid were screened pharmacologically with regard to their influence on the central nervous system. No relation was found between the character and position of substituents and depressant action on the CNS. However, it was remarked that potentiation of the central influence of DOPA probably depends on the position of the p-chlorophenyl group.
D000661:Amphetamine / Q000494:pharmacology; D000700:Analgesics; D000818:Animals; D001921:Brain / Q000187:drug effects*; D002697:Chloral Hydrate / Q000494:pharmacology; D004357:Drug Synergism; D005260:Female; D006591:Hexobarbital / Q000494:pharmacology; D007980:Levodopa / Q000494:pharmacology; D008297:Male; D051379:Mice; D009068:Movement / Q000187:drug effects; D012110:Reserpine / Q000037:antagonists & inhibitors; D012640:Seizures; D012890:Sleep / Q000187:drug effects; D013329:Structure-Activity Relationship; D013388:Succinimides / Q000494:pharmacology*
D000700:Analgesics; D013388:Succinimides; D002697:Chloral Hydrate; D007980:Levodopa; D012110:Reserpine; D006591:Hexobarbital; D000661:Amphetamine