Mumps virus and ovarian cancer.
Thirty-four patients with carcinoma of the ovary were compared with controls matched for age, sex and racial origin. Previous mumps infection was determined by taking a history from the patient, by complement fixation test and by estimating neutralizing antibody titre. No significant differences between the two groups were found for any of the three methods used to estimate previous exposure to mumps virus. Therefore this study did not confirm previous hypotheses that mumps infection confers a significant degree of protection against the development of ovarian cancer. A relatively small proportion of cases could possibly be due to lack of such protection, but in this study not more than 30% at the 5% fiducial limit.
D000230:Adenocarcinoma / Q000276:immunology; D000914:Antibodies, Viral / Q000032:analysis*; D003536:Cystadenocarcinoma / Q000276:immunology; D005260:Female; D006801:Humans; D009109:Mumps virus / Q000276:immunology*; D010051:Ovarian Neoplasms / Q000276:immunology*
D000914:Antibodies, Viral