Acute effects of cadmium on the pregnant rat and embryo-fetal development.
In rats, of the Wistar-Porton strain, a single intravenous injection of 1.25 mg Cd2+ between days 9 and 15 of gestation results in a high incidence (80% of hydrocephalus, together with other malformations in the fetuses, examined on day 20. This dose is critical, since 1.1 mg Cd2+/kg is not teratogenic, while 1.35 mg Cd2+/kg kills all the embryos. Intravenous injection of Cd2+ to the pregnant rat on day 12 causes a dose-dependent inhibition of placental Zn2+ transport. At the teratogenic dose, Zn2+ transport is inhibited by about 75% at 4 hr. Thereafter, inhibition decreases with time but is still significant at 48 hr. At 20 hr after administration of Cd2+ the embryonic concentration of Zn2+ is depressed by 33%. In the whole embryo the activity of the Zn2+-dependent thymidine kinase is inhibited by about 60% at 4 hr and at 20 hr the DNA concentration is reduced significantly. Placental transport of 14C-leucine and 14C-uridine, as well as the embryonic incorporation of these precursors into protein and RNA is unaffected at least at short times after the administration of Cd2+. It is possible therefore, that the teratogenic effects of Cd2+ may be related to the inhibition of DNA synthesis in the embryo.
D000014:Abnormalities, Drug-Induced; D000818:Animals; D002104:Cadmium / Q000494:pharmacology*; D005260:Female; D005865:Gestational Age; D006849:Hydrocephalus / Q000139:chemically induced; D007275:Injections, Intravenous; D007928:Lethal Dose 50; D008098:Litter Size; D008431:Maternal-Fetal Exchange; D010920:Placenta / Q000187:drug effects* / Q000473:pathology; D011247:Pregnancy; D051381:Rats; D013723:Teratogens; D015032:Zinc / Q000378:metabolism / Q000494:pharmacology
D013723:Teratogens; D002104:Cadmium; D015032:Zinc