title: The measurement of occlusion pressure during anaesthesia. A comparison of the depression of respiratory drive by methohexitone and etomidate.
abstract: Occlusion pressure (Po max) was used to indicate the depression of respiratory drive following rapid administration of methohexitone 0.5 mg/kg and etomidate 0.067 mg/kg to fourteen patients under stable light anaesthesia. Methohexitone produced considerably more respiratory depression than etomidate, the difference probably being clinically significant. Po max is the maximum sub-atmospheric pressure generated in the trachea when inspiration is prevented by occlusion of the airway, at functional residual capacity. The factors concerning the use of this simple, non-invasive technique during anaesthesia are discussed, and suggestions made for producing consistent, useful, measurements.
mesh_terms: D000328:Adult; D000368:Aged; D000771:Anesthesia, Intravenous; D002245:Carbon Dioxide / Q000097:blood; D005045:Etomidate / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D008723:Methohexital / Q000494:pharmacology*; D008875:Middle Aged; D011312:Pressure; D011410:Propanidid / Q000494:pharmacology; D011897:Random Allocation; D012119:Respiration / Q000187:drug effects*; D014132:Trachea / Q000502:physiology
chemical_list: D007093:Imidazoles; D002245:Carbon Dioxide; D011410:Propanidid; D008723:Methohexital; D005045:Etomidate