[Effect of vitamin A in significant doses on incorporation of (14C) retinol, acceptor capacity of tRNA and activity of certain enzymes in tissues and plasma membranes of cells in the presence of Guerin's carcinoma].
In rats with Guerin's carcinoma the weight and size of the tumour is twice as low when significant doses of vitamin A are administered. Under these conditions the acceptor capacity of tRNA of the small intestine mucosa as well as the intensity of [14C] retinol incorporation into plasma membranes of its cells decrease essentially, whereas in the mucosa itself the radioactivity remains high. When studying the activity of alkaline phosphatase, amylase in the mucosa and arginase in the liver, a disproportion is found in changes in the enzymes activity on the surface of the small intestine mucosa and in the mucosa homogenate, that may be due to a change in the state of the cell membrane apparatus when the tumour is formed. Under the effect of significant doses of vitamin A there might occur thelysis of the tumour cell membranes, which results in the metabolism normalization.
D000469:Alkaline Phosphatase / Q000378:metabolism; D000681:Amylases / Q000378:metabolism; D000818:Animals; D001119:Arginase / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism; D007421:Intestine, Small / Q000378:metabolism; D008099:Liver / Q000201:enzymology; D008297:Male; D009374:Neoplasms, Experimental / Q000378:metabolism*; D012343:RNA, Transfer / Q000378:metabolism*; D051381:Rats; D014801:Vitamin A / Q000378:metabolism / Q000494:pharmacology*
D014801:Vitamin A; D012343:RNA, Transfer; D000469:Alkaline Phosphatase; D000681:Amylases; D001119:Arginase
Deĭstvie massivnykh doz vitamina A na vkliuchenie [14C] retinola, aktseptornuiu sposobnost' tRNK i aktivnost' nekotorykh fermentov v tkaniakh i plazmaticheskikh membranakh kletok pri kartsinome gerena.