Dissociation constants of 4-acetoxy-piperidines and -thiacyclohexanes at the muscarinic receptor.
The dissociation constants (KA) and the relative intrinsic efficacies (e) of 4-acetoxy-piperidines and -thiacyclohexanes were determined on the guinea-pig isolated left atrium. The differences in the muscarinic potencies are associated with differences in affinities and efficacies, respectively.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D003510:Cyclohexanes; D006168:Guinea Pigs; D006325:Heart Atria / Q000378:metabolism; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism*; D010880:Piperidines / Q000378:metabolism*; D011950:Receptors, Cholinergic / Q000378:metabolism*; D011976:Receptors, Muscarinic / Q000378:metabolism*; D013329:Structure-Activity Relationship
D003510:Cyclohexanes; D010880:Piperidines; D011950:Receptors, Cholinergic; D011976:Receptors, Muscarinic; D000109:Acetylcholine