Antigen- or mitogen-provoked spleen cells produce factors that stimulate the secretion of macrophages of a neutral proteinase degrading cartilage proteoglycans.
Soluble products released by rabbit spleen cells on stimulation with either mitogen or antigen markedly stimulate the secretion of a proteoglycan-degrading neutral proteinase by rabbit bone-marrow macrophages.
D000818:Animals; D000941:Antigens; D001853:Bone Marrow / Q000201:enzymology; D066298:In Vitro Techniques; D008264:Macrophages / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D008934:Mitogens / Q000494:pharmacology; D010447:Peptide Hydrolases / Q000378:metabolism*; D011509:Proteoglycans / Q000378:metabolism*; D011817:Rabbits; D013154:Spleen / Q000166:cytology / Q000187:drug effects*
D000941:Antigens; D008934:Mitogens; D011509:Proteoglycans; D010447:Peptide Hydrolases