title: Investigations into the mechanism of progesterone release by rat lutein cells.
abstract: Vinblastine treatment blocks progesterone release from the lutein cells of superovulated immature rat ovaries, without impairing hormone synthesis, and induces the accumulation of electron-dense granules, 0.2--0.3 micron in diameter, at the juxta-sinusoidal poles of the cells. The hypothesis is advanced that these granules are true secretory organelles and that an exocytotic mechanism underlies the progesterone release from rat lutein cells.
mesh_terms: D000818:Animals; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D003338:Corpus Luteum / Q000378:metabolism*; D003594:Cytoplasmic Granules / Q000187:drug effects / Q000648:ultrastructure; D005089:Exocytosis; D005260:Female; D008184:Luteal Cells / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D011374:Progesterone / Q000097:blood / Q000378:metabolism*; D051381:Rats; D014747:Vinblastine / Q000494:pharmacology
chemical_list: D006063:Chorionic Gonadotropin; D011374:Progesterone; D014747:Vinblastine