Effect of prothrombin complex concentrates on factor VIII inhibitor levels.
Factor VIII inhibitor levels were measured on 261 occasions in 76 hemophilia-A inhibitor patients before and after prothrombin complex concentrate infusion at 13 treatment centers. A rise in inhibitor level to at least twice the pretreatment value occurred in 35 treatment episodes (13.5%), in 27 patients (36%). In 16 patients (21%), such an anamnestic immune response occurred with the first treatment. Factors predisposing to anamnestic responses may include patient idiosyncrasy, low pretreatment inhibitor levels, and exposure to concentrate over several days.
D000917:Antibody Formation; D004306:Dose-Response Relationship, Immunologic; D005169:Factor VIII / Q000276:immunology*; D006467:Hemophilia A / Q000276:immunology*; D006801:Humans; D007156:Immunologic Memory; D008487:Medical History Taking; D011516:Prothrombin / Q000009:adverse effects*; D013997:Time Factors
D011516:Prothrombin; D005169:Factor VIII