Comparison of the bronchodilator and vasodilator activity of sodium azide and sodium nitroprusside in the guinea-pig.
1. Sodium azide and sodium nitroprusside are potent dilators of the intact guinea-pig tracheal preparation in vitro. 2. Both substances are bronchodilators in the anaesthetized guinea-pig in vivo when administered intravenously or by aerosol inhalation. 3. Sodium azide and sodium nitroprusside are also potent vasodilators in the guinea pig. 4. At all doses and by route of administration, including aerosol inhalation, the hypotensive effect predominates over bronchodilatation.
D000403:Airway Resistance / Q000187:drug effects; D000818:Animals; D001386:Azides / Q000008:administration & dosage / Q000494:pharmacology*; D001993:Bronchodilator Agents; D005260:Female; D005292:Ferricyanides / Q000494:pharmacology*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007275:Injections, Intravenous; D007442:Intubation, Intratracheal; D008297:Male; D009599:Nitroprusside / Q000008:administration & dosage / Q000494:pharmacology*; D014132:Trachea / Q000187:drug effects; D014665:Vasodilator Agents
D001386:Azides; D001993:Bronchodilator Agents; D005292:Ferricyanides; D014665:Vasodilator Agents; D009599:Nitroprusside