title: [Antidiphtheria and antitetanus antitoxic immunity indices in the population of the Estonian SSR (an assessment of the effectiveness of a planned vaccine prophylaxis)].
abstract: In 1972-1974 and 1977 in the Estonian SSR children and adults were surveyed for the presence of antibodies against tetanus and diphtheria toxins (toxoids) by means of the passive hemagglutination test. The level of protection against tetanus was revealed to correspond to the proportion of child population covered by vaccination: in 1977, with 98.8% covered by vaccination, the level of protection among children aged 7 to 14 years and adolescents of 15-19 years exceeded 98%; with the increase of age (every 10-15 years) the level of protection against tetanus regularly decreased. This dynamics correlated with the existing terms of postvaccinal immunity and the epidemiological independence of tetanus as infectiion. The level of protection in child population against diphtheria in 1972-1974 and 1977 lagged behind the level of protection against tetanus and the coverage by vaccination. The diphtheria component of adsorbed DPT vaccine seemed to be unable to ensure the sufficient level and intensity of immunity under conditions of a sharply decreased risk of encounter with the infective agent. In persons aged 40 years and over the indices of immunity against diphtheria were higher than against tetanus. These indices resulted from diphtheria infection at the prevaccination period and could serve as an objective sign in following up the decrease of the process of diphtheria epidemics.
mesh_terms: D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D004165:Diphtheria / Q000276:immunology*; D004166:Diphtheria Antitoxin / Q000032:analysis*; D004168:Diphtheria Toxoid / Q000008:administration & dosage*; D004957:Estonia; D005069:Evaluation Studies as Topic; D006386:Hemagglutination Tests; D006801:Humans; D007109:Immunity; D008875:Middle Aged; D013742:Tetanus / Q000276:immunology*; D013743:Tetanus Antitoxin / Q000032:analysis*; D013745:Tetanus Toxoid / Q000008:administration & dosage*
chemical_list: D000907:Antibodies, Bacterial; D004166:Diphtheria Antitoxin; D004168:Diphtheria Toxoid; D013743:Tetanus Antitoxin; D013745:Tetanus Toxoid
vernacular_title: Pokazateli protivodifteriĭnogo i protivostolbniachnogo antitoksicheskogo immuniteta u naseleniia Estonskoĭ SSR (k otsenke éffektivnosti planovoĭ vaktsino-profilaktiki).