title: Pharmacokinetics of pemoline in plasma, saliva and urine following oral administration.
abstract: 1 Pemoline concentrations were measured in plasma and saliva following a single oral dose (37.5 or 50.0 mg) to healthy volunteers. In addition urinary excretion rates and cumulative urinary excretion of the parent compound and its oxazolidinedione metabolite were determined. 2 The plasma curves exhibited a mean elimination half-live of 11.0 +/- 1.2 h (n=4). Peak levels were reached at 2.7 +/- 0.6 h (n=4). The saliva concentrations were about 50% lower than the corresponding plasma concentrations during the elimination phase. During the absorption phase irregularities in the saliva to plasma concentration ratios were observed. 3 In urine 47.0 +/- 8.4% of the dose (n=6) administered was excreted as unchanged drug and only 3.7 +/- 0.8% (n=3) as the oxazolidinedione metabolite. Urinary half-lives were slightly shorter than the corresponding plasma half-lives.
mesh_terms: D000284:Administration, Oral; D000328:Adult; D006801:Humans; D008297:Male; D010389:Pemoline / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism* / Q000652:urine; D012463:Saliva / Q000378:metabolism*; D013997:Time Factors
chemical_list: D010389:Pemoline