[Effect of several compounds on the process of reduction of the 20-keto group of corticosteroids by a culture of Mycobacterium globiforme].
The effect of certain metabolites produced in the metabolism of carbohydrates, proteins and fats on the reduction of the 20-keto group in a number of corticosteroids (prednisone, prenisolone, 6 alpha-methylprednisolone) was studied with the culture of Mycobacterium globiforme. The metabolites and inhibitors of the respiration chain were found to stimulate the 20 beta-reduction of a steroid molecule. The inhibitor of oxidative phosphorylation, 2,4-dinitrophenol, inhibited the reduction of the 20-keto group in a steroid.
D000596:Amino Acids / Q000494:pharmacology; D000654:Amobarbital / Q000494:pharmacology; D000968:Antimycin A / Q000494:pharmacology; D002264:Carboxylic Acids / Q000494:pharmacology; D004140:Dinitrophenols / Q000494:pharmacology; D005227:Fatty Acids / Q000494:pharmacology; D005463:Fluoroacetates / Q000494:pharmacology; D005947:Glucose / Q000494:pharmacology; D007664:Ketosteroids / Q000378:metabolism*; D009161:Mycobacterium / Q000378:metabolism*; D010084:Oxidation-Reduction / Q000187:drug effects; D011190:Potassium Cyanide / Q000494:pharmacology; D012402:Rotenone / Q000494:pharmacology
D000596:Amino Acids; D002264:Carboxylic Acids; D004140:Dinitrophenols; D005227:Fatty Acids; D005463:Fluoroacetates; D007664:Ketosteroids; D012402:Rotenone; D000968:Antimycin A; D000654:Amobarbital; D005947:Glucose; D011190:Potassium Cyanide
Vliianie nekotorykh soedineniĭ na protsess vosstanovleniia 20-ketogruppy kortikosteroidov kul'turoĭ Mycobacterium globiforme.