Sarin transport across excised human skin II: Effect of solvent pretreatment on permeability.
The effect of pretreating callus membranes with dimethyl sulfoxide, dimethylacetamide, dimethylformamide, formamide, dioxane, or methyl orthoformate on sarin permeability was studied at three temperatures to determine the activation energy for transport. In addition, the effect of membrane pretreatment on permeability through callus membranes from either a sarin-carboxypolymethylene gel or a sarin-polymethyl methacrylate gel was studied.
D006801:Humans; D066298:In Vitro Techniques; D008566:Membranes / Q000187:drug effects; D009943:Organophosphorus Compounds / Q000378:metabolism*; D010539:Permeability; D012524:Sarin / Q000378:metabolism*; D012869:Skin Absorption / Q000187:drug effects*; D012997:Solvents; D013696:Temperature; D013997:Time Factors
D009943:Organophosphorus Compounds; D012997:Solvents; D012524:Sarin