[Effect of caerulein on the exocrine pancreas function in man; examinations of dose effects and comparisons with the effect of cholecystokinin/pankreozymin (author's transl)].
The purpose of the study was to examine the secretory response of the exocrine pancreas in man to various doses of the synthesised decapeptide Caerulein (Takus), 5, 10 and 20 ng/kg Caerulein injected intravenously during an infusion of 0,5 CU/kg/h Secretin (GIH) produced a linear increase of enzyme secretion (amylase, lipase, trypsin and chymotrypsin) and also an increase in the water and bicarbonate secretion of the pancreas which is induced by Secretin. The injection of 40 ng/kg Caerulein led to no further increase of the ecbolic function. The intravenous injection of 1 Ivy dog unit (IDU/kg and 20 and 40 ng/kg Caerulein have an identical effect on the exocrine pancreas, there were no statistic differences.
D000328:Adult; D002108:Ceruletide / Q000494:pharmacology*; D002766:Cholecystokinin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004386:Duodenum; D005260:Female; D006801:Humans; D007419:Intestinal Secretions / Q000032:analysis; D008297:Male; D010179:Pancreas / Q000187:drug effects*; D010186:Pancreatic Function Tests
D002108:Ceruletide; D002766:Cholecystokinin
Wirkung von Caerulein auf die exokrine Pankreasfunktion des Menschen; Dosiswirkungsuntersuchungen und Vergleiche mit dem Effekt von Cholecystokinin/Pankreozymin.