Inhibition of neuronal and extraneuronal uptake of noradrenaline by ketamine in the isolated perfused rat heart.
The effect of ketamine on the uptake of 3H-noradrenaline in the isolated perfused rat heart was studied. A dose-dependent inhibition of uptake by both neuronal and extraneuronal processes was found. These effects may account for the positive chronotropic and pressor effects of the drug.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005110:Extracellular Space / Q000187:drug effects; D006321:Heart / Q000187:drug effects; D066298:In Vitro Techniques; D007649:Ketamine / Q000494:pharmacology*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism*; D010477:Perfusion; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects / Q000378:metabolism
D011941:Receptors, Adrenergic; D007649:Ketamine; D009638:Norepinephrine