[Effect of alpha-tocopherol on the enzymatic activity of phospholipid biosynthesis and breakdown in burn injury].
Burns affected the content of L-alpha-glycerophosphate /L-alpha-GP/ in rats; its level was reduced within 15 days after burns. Phasic changes in L-alpha-glycerophosphate dehydrogenase and glycerokinase activities in liver and brain tissues and phospholipase A in blood were also observed. Intraperitoneal administration of alpha-tocopheryl acetate into rats subjected to burns abolished the decrease in content of L-alpha-GP although the activity of the drug varied within this 15 day period. In brain the activity of these enzymes was increased 2-3-fold. The data obtained are in good agreement with those published previously and indicating loss of phospholipids in liver and brain tissus following burns.
D000818:Animals; D001921:Brain / Q000378:metabolism; D002056:Burns / Q000188:drug therapy* / Q000378:metabolism; D004789:Enzyme Activation / Q000187:drug effects; D005260:Female; D008054:Lipid Peroxides / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats; D013997:Time Factors; D014810:Vitamin E / Q000627:therapeutic use*
D008054:Lipid Peroxides; D010743:Phospholipids; D014810:Vitamin E
Vliianie al'fa-tokoferola na aktivnost' nekotorykh fermentov biosinteza i raspada fosfolipidov pri ozhogovoĭ travme.