[Ultrastructure of the liver in patients with cholesterol stones receiving chenodesoxycholic acid (author's transl)].
The ultrastructure of the liver was investigated in 5 normal persons and 10 patients with cholesterol stones. In the patients numerous intramitochondrial crystals could be found; precipitated cholesterol-digitonin complexes were found as well in the canaliculi, the sinus and the pericanalicular areas. 5 patients received chenodesoxycholic acid (10 mg/kg/day); liver biopsies taken 3 and 6 months after start of treatment did not show any more the changes described above.
D002635:Chenodeoxycholic Acid / Q000627:therapeutic use*; D002769:Cholelithiasis / Q000188:drug therapy / Q000473:pathology*; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D006801:Humans; D008099:Liver / Q000648:ultrastructure*; D008930:Mitochondria, Liver / Q000648:ultrastructure
D002635:Chenodeoxycholic Acid
Ultrastrukturelle Untersuchungen der Leber bei Patienten mit Cholesteringallensteinen unter Chenodesoxycholsäure-Therapie.