title: Dependence of the guinea pig IgE and IgG1 immune responses on the inclusion of potassium in the preparation of alum adjuvant.
abstract: Primary immunization with alum prepared using AlK(SO4)2 and adjuvant enhanced IgE production in the guinea pig. Alum prepared from Al2 (SO4)3 showed greatly reduced IgE and IgG1 anti-EA titers. This variance in immunoglobulin titer was observed only in the guinea pig. Both rats and mice respond to alum preparations prepared from either AlK(SO4)2 or Al2(SO4)3 equally as well.
mesh_terms: D000276:Adjuvants, Immunologic; D000534:Alum Compounds / Q000494:pharmacology*; D000535:Aluminum / Q000494:pharmacology*; D000818:Animals; D000917:Antibody Formation; D001200:Ascaris / Q000276:immunology; D006168:Guinea Pigs; D007073:Immunoglobulin E / Q000096:biosynthesis*; D007074:Immunoglobulin G / Q000096:biosynthesis*; D008297:Male; D051379:Mice; D010047:Ovalbumin / Q000276:immunology; D010323:Passive Cutaneous Anaphylaxis; D011188:Potassium / Q000494:pharmacology*; D051381:Rats
chemical_list: D000276:Adjuvants, Immunologic; D000534:Alum Compounds; D007074:Immunoglobulin G; D007073:Immunoglobulin E; D010047:Ovalbumin; D000535:Aluminum; D011188:Potassium