Increased prostaglandin F2 alpha and E2 production in late passage WI38 diploid fibroblasts.
The prostaglandin (PG) F2alpha and E2 concentrations in the culture medium of WI38 cells were determined at various passage levels. It was found that late passage cells produce significantly higher amounts of both PG F2alpha and PG E2.
D002460:Cell Line; D003470:Culture Media; D004171:Diploidy; D005347:Fibroblasts; D006801:Humans; D008168:Lung / Q000196:embryology; D011458:Prostaglandins E / Q000096:biosynthesis*; D011460:Prostaglandins F / Q000096:biosynthesis*
D003470:Culture Media; D011458:Prostaglandins E; D011460:Prostaglandins F