Movement of thallous ion across the ascites cell membrane.
The movement of thallous ion (Tl+) across the ascites cell membrane has been characterized. Analogous to previous findings for 86Rb (used as a tracer for K+), 204Tl+-influx could be resolved into three components: a ouabain-inhibitable "pump" flux, a passive flux, and a furosemide- or NO-3-sensitive "exchange" flux. Although Tl+ moved approximately nine times faster across the membrane than K+, the pump/leak ratio was equal for the two ions. This suggests that the pump- and leak-pathways share a common rate-limiting step. The exchange mechanism was shown to provide close coupling between the Tl+- and K+-gradients.
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D002286:Carcinoma, Ehrlich Tumor; D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism*; D004058:Diffusion; D005665:Furosemide / Q000494:pharmacology; D051379:Mice; D009566:Nitrates / Q000494:pharmacology; D010042:Ouabain / Q000494:pharmacology; D011188:Potassium / Q000378:metabolism; D013793:Thallium / Q000378:metabolism*
D009566:Nitrates; D010042:Ouabain; D005665:Furosemide; D013793:Thallium; D011188:Potassium