title: Acute poisoning from over-the-counter sleep preparations.
abstract: All cases received by the Rocky Mountain Poison Center involving over-the-counter (OTC) sleep preparations were studied during an 18-month period to elucidate 1) the range of toxicity; 2) characteristic symptoms, and 3) the time of onset of symptoms. In 155 cases reviewed retrospectively, the three most commonly ingested agents were Sominex, Nytol and Sleepeze. Multiple ingestions were also involved. Symptomatology was equally divided among no symptoms, mild symptoms and possible life-threatening symptoms. The least amount taken to produce possible life-threatening symptoms was 16 Sominex, 18 Nytol and 15 Sleepeze, although the average amount producing the same symptoms was approximately twice that. These symptoms were seen within six hours in all but three of the 39 cases presenting with these symptoms. There were no deaths.
mesh_terms: D000293:Adolescent; D000328:Adult; D000631:Aminopyridines / Q000506:poisoning*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy; D002648:Child; D002675:Child, Preschool; D003128:Coma / Q000188:drug therapy; D006212:Hallucinations / Q000188:drug therapy; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D007223:Infant; D008701:Methapyrilene / Q000506:poisoning*; D004366:Nonprescription Drugs; D010830:Physostigmine / Q000627:therapeutic use; D012189:Retrospective Studies; D012457:Salicylamides / Q000506:poisoning*; D012601:Scopolamine / Q000506:poisoning*; D012640:Seizures / Q000188:drug therapy
chemical_list: D000631:Aminopyridines; D004366:Nonprescription Drugs; D012457:Salicylamides; D010830:Physostigmine; D008701:Methapyrilene; D012601:Scopolamine