title: Histological changes produced in skin by equally erythemogenic doses of UV-A, UV-B, UV-C and UV-A with psoralens.
abstract: The sequential light microscopic histological changes produced in human skin by a single exposure of UV-A, UV-B, UV-C and oral 8-methoxypsoralen plus UV-A (PUVA) causing approximately equal degress of delayed erythema response, have been evaluated. UV-C and UV-B affect the epidermis to a greater degree than UV-A, while UV-A affects the dermis to a greater degree than UV-B and UV-C. PUVA has prominent effects on both epidermis and dermis, differing in degree from those changes induced by UV-A, UV-B, and UV-C and are longer lasting. The sequence of histological changes following UV exposure is completed more rapidly after exposure to shorter UV wavelengths.
mesh_terms: D000328:Adult; D004890:Erythema / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008730:Methoxsalen / Q000494:pharmacology*; D010778:Photochemotherapy / Q000009:adverse effects*; D011829:Radiation Dosage; D012867:Skin / Q000473:pathology / Q000528:radiation effects*; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: D008730:Methoxsalen