[State of the vascular wall in experimental hypertension induced by the administration of indomethacin in combination with a saline drink].
It is shown that various types of vessels (elastic, musculo-elastic, and muscular) possess initially different capacity for synthesizing and destroying prostaglandins. Under the effect of indomethacin and salt load considerable changes occur in the synthesis and metabolism of prostaglandins and the closely related system of cyclic nucleotides in the vessels of experimental animals. The character of these changes suggests the predominance of constrictive vascular reactions, which was confirmed by the results of functional tests on segments of the aorta and femoral arteries. It was shown also that the walls of small arteries of different organs, the kidneys in particular, undergo marked structural changes resulting in their thickening and narrowing of the lumen. These functional and structural changes may underlie the increase in peripheral vascular resistance and be the principal pathogenic mechanism of hypertension.
D000818:Animals; D001011:Aorta / Q000187:drug effects; D001808:Blood Vessels / Q000187:drug effects*; D004547:Elastic Tissue / Q000187:drug effects; D005263:Femoral Artery / Q000187:drug effects; D006973:Hypertension / Q000139:chemically induced* / Q000378:metabolism; D007213:Indomethacin / Q000008:administration & dosage*; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D011448:Prostaglandin Antagonists / Q000008:administration & dosage; D051381:Rats; D012965:Sodium Chloride / Q000008:administration & dosage*; D013997:Time Factors
D011448:Prostaglandin Antagonists; D012965:Sodium Chloride; D007213:Indomethacin
Sostoianie sosudistoĭ stenki pri éksperimental'noĭ gipertonii, vyzvannoĭ vvedeniem indometatsina v sochetanii s solevym pit'em.