Induction of unscheduled DNA synthesis in mouse germ cells following 1,2-dibromo-3-chloropropane (DBCP) exposure.
Acute toxicity studies of 1,2-dibromo-3-chloropropane (DBCP) in mice demonstrated that the respective LD50 values for prepubertal and adult male mice were 180.7 mg/kg (154.0-197.5 mg/kg body weight) and 123 mg/kg (100.5-141.5 mg/kg body weight) which were significantly different. The slopes of the dose-response curves (1.2) were steep and essentially the same, indicating a narrow margin of safety. A single maximally tolerated dose of DBCP (100 mg/kg) administered intraperitoneally to prepubertal male mice induced significant unscheduled DNA synthesis in the premeiotic germ cells but not in spermatozoa.
D000818:Animals; D000969:Antinematodal Agents / Q000633:toxicity*; D004247:DNA / Q000378:metabolism; D004261:DNA Replication; D004305:Dose-Response Relationship, Drug; D006846:Hydrocarbons, Halogenated / Q000633:toxicity*; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D011407:Propane / Q000031:analogs & derivatives* / Q000633:toxicity; D013094:Spermatozoa / Q000378:metabolism*
D000969:Antinematodal Agents; D006846:Hydrocarbons, Halogenated; D004247:DNA; C007318:1,2-dibromo-3-chloropropane; D011407:Propane