[Comparison of 2-aminopyridine, 3-aminopyridine and 4-aminopyridine hydrochlorides and iodomethylates by the degree of decrease in curare toxicity].
The authors carried out studies on rats with apnoea, indiced by (+)-tubucurarine and found protective action, due to galantamine, neostigmine, hydrochlorides and jodometilates of 2-aminopyridine, 3-aminopyridine and 4-aminopyridine. Jodmethylates had protective action in larger doses in comparison with the respective hydrochlorides of nonsubstituted pyridilamines. The authors proposed a method for determination and comparison of the effect of compounds, eliminating the action of antidepolarizating myorelaxants, on tubocurarine toxicity.
D000631:Aminopyridines / Q000494:pharmacology*; D000818:Animals; D001049:Apnea / Q000139:chemically induced; D003472:Curare / Q000037:antagonists & inhibitors*; D003643:Death; D004305:Dose-Response Relationship, Drug; D005702:Galantamine / Q000494:pharmacology; D006847:Hydrocarbons, Iodinated; D006851:Hydrochloric Acid; D009388:Neostigmine / Q000494:pharmacology; D051381:Rats; D013997:Time Factors; D014403:Tubocurarine / Q000037:antagonists & inhibitors
D000631:Aminopyridines; D006847:Hydrocarbons, Iodinated; D005702:Galantamine; D009388:Neostigmine; D003472:Curare; D006851:Hydrochloric Acid; D014403:Tubocurarine
Sravniavane na khidrokhloridite i ĭodmetilatite na 2-aminopiridina, 3-aminopiridina i 4-aminopiridina po stepenta na ponizhavane na kurarinovata toksichnost.