Some effects of continuous low-dose congenital exposure to methylmercury on organ growth in the rat fetus.
Congenital low-dose exposure of rat fetuses to methylmercury produced smaller offspring without anatomical abnormalities. The present study explored the mechanisms of the smallness of fetuses. The pregnant rats were given methylmercury water (25 ppm) from day 1 of pregnancy continuously until day 20 of gestation. There was a negative correlation of fetal weight and maternal and fetal mercury burden. The whole organ DNA and protein content of the livers and kidneys in the experiments were significantly lower than the control (P less than 0.05) indicating that there were fewer cells per organ in the mercury exposed fetuses. When the data were compared on a per gram of tissue basis, there was no significanct difference, indicating that the number and size of the cells of each were not diminished. The incorporation of 3H-thymidine into fetal tissue DNA was also substantially lower in the experimental group indicating decreased proliferative activity. We conclude from this study that, at least for some major organs, the decreased size in the mercury exposed fetuses is due to fewer cells in the organs due to decreased proliferative activity.
D000014:Abnormalities, Drug-Induced; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D004247:DNA / Q000032:analysis; D005260:Female; D005317:Fetal Growth Retardation / Q000139:chemically induced*; D007668:Kidney / Q000032:analysis; D008099:Liver / Q000032:analysis; D008767:Methylmercury Compounds / Q000008:administration & dosage*; D009024:Morphogenesis / Q000187:drug effects; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy; D051381:Rats / Q000196:embryology*; D013936:Thymidine / Q000378:metabolism
D008767:Methylmercury Compounds; D004247:DNA; D013936:Thymidine