[Effect of hypoxia on the contractile activity of smooth muscle cells of the thoracic lymphatic duct].
Hypoxia (95% N2; 5% CO2) led to complete or partial inhibition of spontaneous contractile activity of isolated segment of the rat thoracic lymphatic duct, PO2 of perfused solution being 5--10 mm Hg. Reoxygenation restored rhythmical although more frequent contractions of the smooth muscle cells. Excitability of cells membrane tested with KCl, BaCl2, and noradrenaline during hypoxic period proved lower during this decreased PO2. Preliminary depolarization with KCl, BaCl2, and noradrenaline of cells membrane delayed the inhibition of contractile activity during hypoxia. Compared with the portal vein, lymphatic duct revealed a greater resistance to hypoxia. The hypoxia seems to affect first the smooth muscle cell membrane which leads to modification of the contraction character.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000378:metabolism; D002463:Cell Membrane Permeability; D005260:Female; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D009119:Muscle Contraction; D009130:Muscle, Smooth / Q000378:metabolism / Q000503:physiopathology*; D009638:Norepinephrine; D010507:Periodicity; D010725:Phosphocreatine / Q000378:metabolism; D051381:Rats; D012964:Sodium / Q000378:metabolism; D013897:Thoracic Duct / Q000378:metabolism / Q000503:physiopathology*
D010725:Phosphocreatine; D000255:Adenosine Triphosphate; D012964:Sodium; D002118:Calcium; D009638:Norepinephrine
Vliianie gipoksii na sokratitel'nuiu aktivnost' gladkomyshechnykh kletok grudnogo limfaticheskogo protoka.