Typical hairy-cell leukaemia with IgGk paraproteinaemia.
A case of hairy-cell leukaemia (HCL) with IgG(k) paraprotein is described. The typical clinico-pathological features of the patient are stressed, and it is shown that the hairy cells (HCs) were producing and secreting IgGk. The case is placed in a more general context by the demonstration that HCs from other typical cases of HCL produce and secrete IgG. These findings conclusively demonstrate that HCL is a B-cell disease.
D000368:Aged; D003593:Cytoplasm / Q000276:immunology; D005260:Female; D006801:Humans; D006942:Hypergammaglobulinemia / Q000276:immunology*; D007074:Immunoglobulin G; D007943:Leukemia, Hairy Cell / Q000276:immunology*; D007962:Leukocytes / Q000276:immunology; D011947:Receptors, Antigen, B-Cell / Q000032:analysis
D007074:Immunoglobulin G; D011947:Receptors, Antigen, B-Cell