[Effects of propranolol and metoprolol on beta-adrenergic metabolic responses (author's transl)].
In ten healthy volunteers infusion of 7 micrograms/kg orciprenaline produced typical changes in carbohydrate and fat metabolism due to beta-adrenergic stimulation. Pretreatment with intravenously administered propranolol or metoprolol significantly inhibited orciprenaline-induced changes in systolic blood pressure, heart rate and plasma FFA, potassium, glucose and glycerol levels. Propranolol (0.1 mg/kg) seemed to be more effective than metoprolol (0.2 mg/kg) even in inhibiting predominantly beta 1-adrenergic responses.
D000328:Adult; D001786:Blood Glucose; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D005990:Glycerol / Q000097:blood; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D009921:Metaproterenol / Q000494:pharmacology; D008790:Metoprolol / Q000494:pharmacology*; D011188:Potassium / Q000097:blood; D011412:Propanolamines / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology*
D001786:Blood Glucose; D011412:Propanolamines; D009921:Metaproterenol; D011433:Propranolol; D008790:Metoprolol; D005990:Glycerol; D011188:Potassium
Der Einfluss von Propranolol und Metoprolol auf betaadrenerge Stoffwechselreaktionen.