[Acute toxicity of orthochloroparanitroanisole (OCNA) and orthochloroparaanisidine (OCPA) (author's transl)].
The acute effects of two industrial substances were studied in mice, rats, rabbits and guinea pigs: - lethal concentration 50 (L.D. 50) in mice and rats after intraperitoneal and oral administration; - investigation of cell growth inhibition (Hela cells), I.D.50 = inhibitory dose 50%; - neuropharmacological effects Histopathological investigations and biochemical analysis pointed out hepatic and renal damages; besides hematological disturbances were found. Both products had mild irritant effects on rabbits skin and eyes. They produced skin sensitization in guinea pigs.
D000814:Aniline Compounds / Q000633:toxicity*; D000818:Animals; D000840:Anisoles / Q000633:toxicity*; D001341:Autonomic Nervous System / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects; D005123:Eye / Q000187:drug effects; D005260:Female; D006168:Guinea Pigs; D006367:HeLa Cells; D006801:Humans; D007509:Irritants; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009578:Nitrobenzenes / Q000633:toxicity*; D011817:Rabbits; D051381:Rats; D012867:Skin / Q000187:drug effects; D013045:Species Specificity; D013552:Swine; D013997:Time Factors
D000814:Aniline Compounds; D000840:Anisoles; D007509:Irritants; D009578:Nitrobenzenes
Etude de toxicité aiguë de l'orthochloroparanitroanisole (OCNA) et de l'orthochloroparaanisidine (OCPA).