Hydrodynamic characterization of a spin-filter dissolution device.
The spin-filter dissolution device was characterized using a two-dimensional convective diffusion model. Experimental model testing involved analysis of dissolution rates from nondisintegrating salicylic acid disks. The disks were prepared as double-layer tablets, with an ethylcellulose layer as a nondissolving surface. For each dissolution run, the disk was positioned so that the dissolving salicylic acid surface was parallel to the flow of the circulating fluid. Experimental variables included the stirring speed, the tablet radius, and the distance of the tablet from the stirring source. At the farthest distance from the stirring source, the average numerical exponents for stirring speed and tablet radius were 0.58 and 1.54, respectively, which compare favorably with the values of 0.50 and 1.50 from the model. When the dissolving salicylic acid surface was positioned closer to the stirring source, the numberical exponent for the stirring speed increased significantly, while the average numerical exponent for the tablet radius was lowered to 1.07, indicating a change is dissolution mechanism as a function of distance from the stirring source. These data indicate that dissolution rates are not necessarily proportional to surface area as predicted by the Nernst equation and that distance from the stirring source is significant.
D002626:Chemistry, Pharmaceutical / Q000295:instrumentation; D004058:Diffusion; D005374:Filtration / Q000295:instrumentation; D008433:Mathematics; D008956:Models, Chemical; D012459:Salicylates; D012995:Solubility; D013607:Tablets
D012459:Salicylates; D013607:Tablets