Decreased pentobarbital sleeptime following a single intraperitoneal injection of cedar-derived sesquiterpenes.
Within one day after a single IP injection of cedar sesquiterpenes into mice, pentobarbital sleeptime was reduced by 40%. The estimated ED50 is 50 mg terpenes/kg body weight. The mice recovered from this terpene-induced reduction in the strength of hypnosis within 6 days after the terpene injection. The potency of the terpenes, the rapidity of their action, and the duration of their effectiveness in modulating a drug response suggest their usefulness as a pharmacological tool.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010424:Pentobarbital / Q000494:pharmacology*; D012717:Sesquiterpenes / Q000008:administration & dosage / Q000494:pharmacology*; D012890:Sleep / Q000187:drug effects*; D013997:Time Factors
D012717:Sesquiterpenes; D010424:Pentobarbital