In vivo effect of human chorionic gonadotropin on the migration of inflammatory cells in intact or castrated male and female guinea-pigs. A quantitative histological study. I. Study of intact male and female guinea-pigs.
The migration of inflammatory cells and fibroblasts into dacron mesh tissue (Mersilene), immersed in a suspension of live BCG and implanted s.c. into intact male and female guinea-pigs treated with either commercial or purified human chorionic gonadotropin was investigated. Cell counts showed that in treated animals a significant reduction (about 70%) of whole cells occurred. The effect was maximal on neutrophil granulocytes (a reduction of 85%) by Day 5 after grafting. No significant differences appeared between males and females or between commercial and purified human chorionic gonadotropin.
D000818:Animals; D002452:Cell Count; D002465:Cell Movement / Q000187:drug effects; D006063:Chorionic Gonadotropin / Q000494:pharmacology*; D003864:Depression, Chemical; D005260:Female; D005347:Fibroblasts / Q000502:physiology; D006168:Guinea Pigs; D007249:Inflammation / Q000503:physiopathology; D007958:Leukocyte Count; D008214:Lymphocytes / Q000502:physiology; D008264:Macrophages / Q000502:physiology; D008297:Male; D009504:Neutrophils / Q000502:physiology*
D006063:Chorionic Gonadotropin