[Action of metoclopramide bromide and metoclopramide chloride on the lower esophagogastric junction and the peristalsis of the lower 3d of the esophagus].
In 10 patients with esophageal hiatus hernia the effect of metoclopramide bromide and metoclopramide chloride compared with placebo, was studied by the double blind method. Both drugs produced an increase of the lower esophageal sphincter pressure and of the peristalsis of the lower third of the esophagus, only being statistically significative the action of metoclopramide chloride on the perstalsis. No significative side-effects were noted.
D000328:Adult; D000368:Aged; D001965:Bromides / Q000494:pharmacology; D002712:Chlorides / Q000494:pharmacology; D004311:Double-Blind Method; D004943:Esophagogastric Junction / Q000187:drug effects* / Q000503:physiopathology; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006551:Hernia, Hiatal / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D008297:Male; D008787:Metoclopramide / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008875:Middle Aged; D010528:Peristalsis / Q000187:drug effects*; D010919:Placebos
D001965:Bromides; D002712:Chlorides; D010919:Placebos; D008787:Metoclopramide
Acción del bromuro de metoclopramida y del chlorhidrato de metoclopramida sobre el esfínter esofágico inferior y la peristalsis del tercio inferior del esófago.