Cellular allergy - one way to ozena? Rhinomanometry and histology in animal experiments compared with clinical aspects.
Based on rhinorheomanometric examinations supplemented by rhinoscopic and histological findings, evidence could be provided that an allergy of type IV in the Coombs and Gell classification can be challenged in the nasal mucous membrane as well. The tuberculin reaction in guinea pigs was used as test model. A critical evaluation of test results, immunological literature and some related challenge tests as to delayed reactions in human medicine are the reason for assuming the clinical symptoms of hypertrophy preceding ozena to be the clinical correlation to a type IV reaction. This correlation to clinical symptoms is not only borne out by animal experiments but also by years of experience in intranasal challenge tests, in rhinorheomanometry including the preparation of allergens for intranasal challenge.
D000818:Animals; D006168:Guinea Pigs; D008365:Manometry; D009297:Nasal Mucosa / Q000473:pathology; D009299:Nasal Provocation Tests; D012222:Rhinitis, Atrophic / Q000276:immunology* / Q000473:pathology