Serum phenobarbital and barbital concentrations in rats on a limited food regimen.
Serum barbiturate levels were tracked for several hours in food deprived rats given 40, 60 or 80 mg/kg (SC) of either phenobarbital or barbital. All 3 phenobarbital doses produced peak serum drug levels at 1.5 hr postinjection. Serum barbital concentrations peaked 3 hr after both 60 and 80 mg/kg barbital doses while the 40 mg/kg dose produced a stable low drug level throughout the 4 postinjection hours. For both barbiturates administered, 40 mg/kg doses produced lower serum drug levels than either 60 or 80 mg/kg. The differences in serum drug concentrations between the latter two dose levels were inconsistent over time.
D000818:Animals; D001462:Barbital / Q000097:blood*; D001463:Barbiturates / Q000097:blood*; D005508:Food Deprivation / Q000502:physiology*; D008297:Male; D010634:Phenobarbital / Q000097:blood*; D051381:Rats; D013997:Time Factors
D001463:Barbiturates; D001462:Barbital; D010634:Phenobarbital