Separation of penicillin G potassium and its degradation products using high-pressure liquid chromatography.
A high-pressure liquid chromatographic technique was developed for the separation of penicillin G potassium and several of its decomposition products. The method utilized a buffered acetonitrile-phosphate mobile phase on a reversed-phase C18 column. Separation of penicillin G potassium and six degradation products was attained within 25 min.
D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D006868:Hydrolysis; D008722:Methods; D010400:Penicillin G / Q000302:isolation & purification*
D010400:Penicillin G