[Cholinergic regulation of transcription in the liver].
The rate of the RNA synthesis in the rat liver was enhanced 6 hours after intramuscular administration to rats of acetylcholine, carbamylcholine or chlorosil at doses of 20, 1 and 2 mg/kg, respectively. At a dose of 0.025 mg/kg chlorosil failed to influence the transcription rate, but partially blocked its stimulation by carbamylcholine. Chlorosil and carbamylcholine did not change the RNA synthesis rate in isolated hepatocytic nuclei. It is suggested that the effect is mediated by their interaction with the cholinoreceptor or with the cell plasmatic membrane sites structurally associated with it.
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D002217:Carbachol / Q000494:pharmacology*; D005260:Female; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D014158:Transcription, Genetic / Q000187:drug effects*
D012313:RNA; D002217:Carbachol; D000109:Acetylcholine
K voprosu o kholinergicheskoĭ reguliatsii protsessov transkriptsii v pecheni.