title: [Ultrastructural changes in the hepatocytes of dogs continuously exposed to chronic low-dose gamma irradiation].
abstract: Electron microscopy of the liver of dogs exposed to chronic 6-year gamma-irradiation from the CO60 source demonstrated early changes in the hepatocyte structure at a relatively low dosage of 63 rad for 3 years. A comparative study of the submicroscopic reaction of hepatocytes of 3 groups of test dogs showed pronounced changes in the endoplasmatic reticulum: vacuolar transformation balloon dystrophy. The heterogeneity of ultrastructural changes of different hepatocytes was probably associated with a simultaneous development of processes of injury, reparation and adaptation of intracellular structures during the long-term gamma-irradiation exposure. Parallel development of these processes assured reparative biosynthesis to maintain the normal hepatic function.
mesh_terms: D000818:Animals; D003037:Cobalt Radioisotopes; D004285:Dogs; D004721:Endoplasmic Reticulum / Q000528:radiation effects; D005720:Gamma Rays; D007728:Kupffer Cells / Q000528:radiation effects; D008062:Lipofuscin / Q000528:radiation effects; D008099:Liver / Q000528:radiation effects* / Q000648:ultrastructure; D008247:Lysosomes / Q000528:radiation effects; D008854:Microscopy, Electron; D008930:Mitochondria, Liver / Q000528:radiation effects; D013997:Time Factors
chemical_list: D003037:Cobalt Radioisotopes; D008062:Lipofuscin
vernacular_title: Ul'trastrukturnye izmeneniia gepatotsitov sobak v usloviiakh postoiannogo khronicheskogo gamma-oblucheniia v malykh dozakh.