Scintigraphic and radiocirculographic studies on the effect of As2 on cat cerebral circulation.
Various well-known agents with a favourable influence on cerebral circulation were used as a basis for creating new methods to asses the effects on this vascular region in experimental animals. A technique was worked out for radiocirculography and simultaneous radiometry, as well as for scanning and simultaneous radiometry of cat brain. Radiocirculography, followed by scintigraphy, proved to be among the best methods used for assessment of the effect of As2 on cerebral circulation. Simultaneous radiometry with the methods mentioned above had only orientational value. Radiocirculographic and scanning data after application of As2 in a dose of 10 mg/kg are close to those for nicotinic acid in a dose of 1 mg/kg. Similar to the data of the isotopic methods after application of As2 in a dose of 5 mg/kg are the results obtained with 5 mg/kg cinnarizin, which suggests a similar machanism of action.
D000818:Animals; D001158:Arteries; D001921:Brain / Q000000981:diagnostic imaging; D002339:Carotid Arteries / Q000187:drug effects; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D002936:Cinnarizine / Q000031:analogs & derivatives / Q000494:pharmacology*; D009539:Nicotinic Acids / Q000494:pharmacology; D010208:Papaverine / Q000494:pharmacology; D010841:Pia Mater / Q000098:blood supply; D010879:Piperazines / Q000494:pharmacology*; D011877:Radionuclide Imaging; D012711:Serum Albumin, Radio-Iodinated; D014665:Vasodilator Agents
D009539:Nicotinic Acids; D010879:Piperazines; D012711:Serum Albumin, Radio-Iodinated; D014665:Vasodilator Agents; D002936:Cinnarizine; D010208:Papaverine