Role of operative trauma: explosive metastases of similar size following amputation of the primary leg tumor.
Trauma produced by amputation of a limb bearing the primary tumor influenced pulmonary metastases of the Carcinosarcoma of Walker 256 of the rat. This enhancement was present in 38% of the animals following the removal of a limb bearing the primary tumor; and in 29% of those in which the controlateral limb without tumor was amputated. A significant prolongation of the clotting time, an elevation of fibrinogen factor II and VII and a rapid consumption of factor VIII present soon after trauma may have been the parameter responsible for the increase of pulmonary metastases seen in this study.
D000818:Animals; D001777:Blood Coagulation; D002279:Carcinoma 256, Walker / Q000097:blood / Q000556:secondary* / Q000601:surgery; D005121:Extremities; D005260:Female; D008175:Lung Neoplasms / Q000556:secondary*; D009366:Neoplasm Seeding; D009360:Neoplastic Cells, Circulating; D011183:Postoperative Complications; D051381:Rats; D014947:Wounds and Injuries