[Influence of desoxycorticosterone on the reaction of isolated segments of coronary arteries to noradrenaline in the presence of pyrogallol].
The effect of the desoxycorticosterone on the noradrenaline-induced relaxation of coronary arteries waw studied in vitro, after a known inhibitor of COMT, pyrogallol. Relaxation induced by noradrenaline was enhanced by desoxycorticosterone. Relaxation in response to noradrenaline was increased by desoxycorticosterone. Pyrogallol potentiated the responses of coronary strips to noradrenaline and also reduced or abolished the enhancing effects of desoxycorticosterone. It is concluded that desoxycorticosterone enhances the reponse of coronary smooth muscle to noradrenaline by inhibiting and enzymatic pathway for the inactivation of catecolamines.
D000818:Animals; D001158:Arteries / Q000187:drug effects; D002417:Cattle; D003331:Coronary Vessels / Q000187:drug effects*; D003900:Desoxycorticosterone / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004357:Drug Synergism; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology*; D011748:Pyrogallol / Q000494:pharmacology*
D011748:Pyrogallol; D003900:Desoxycorticosterone; D009638:Norepinephrine
Influenza del desossicorticosterone sulle risposte di segmenti di arterie coronarie isolate alla noradrenalina, in presenza di pirogallolo.