title: Haloperidol produces hypothermic effects in rats.
abstract: Intraperitoneal administration of either haloperidol or chlorpromazine produced hypothermia both in the cold (8 degrees C) and at room temperature (22 degrees C). The hypothermia was brought about both by a decrease in metabolic heat production and an increase in the cutaneous temperature of tail and foot skin. However, at a higher temperature (29 degrees C), there were no changes in rectal temperature and other thermoregulatory responses.
mesh_terms: D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D001833:Body Temperature Regulation / Q000187:drug effects; D002746:Chlorpromazine / Q000494:pharmacology*; D006220:Haloperidol / Q000494:pharmacology*; D007035:Hypothermia / Q000503:physiopathology*; D008297:Male; D051381:Rats
chemical_list: D006220:Haloperidol; D002746:Chlorpromazine