The C4 system: formal and population genetics.
The present study shows that the C4 system as investigated by high voltage agarose gel electrophoresis is highly polymorphic. In a series of unrelated Norwegian adults, where C4 types have been ascertained through segregation in families, six different haplotypes have been found to occur with a frequency exceeding 1%. The genotype frequencies in the population fit expected Hardy-Weinberg distribution. In family material comprising 89 matings with 327 children the distribution of offspring is as expected according to autosomal codominant inheritance of haplotypes.
D003181:Complement C4 / Q000235:genetics*; D004587:Electrophoresis, Agar Gel; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D009664:Norway; D010375:Pedigree; D010641:Phenotype; D011110:Polymorphism, Genetic
D003181:Complement C4