Evaluation of gamma radiation therapy in experimentally induced hemorrhagic pancreatitis in dogs.
Acute bile-trypsin pancreatitis was induced in two groups of six dogs each. One group was given supportive treatment only; the second group was treated with irradiation of the pancreas (400 rad). A third group of six dogs was irradiated, but pancreatitis was not induced. A 13-fold increase in survival time was observed in the dogs with pancreatitis which had been irradiated. Irradiation alone was found to reduce the volume of pancreatic secretion with a relative increase in trypsin content. Modification of the inflammatory reaction by irradiation and reduction in pancreatic secretion probably account for the therapeutic effect.
D000208:Acute Disease; D000681:Amylases / Q000097:blood; D000818:Animals; D004283:Dog Diseases / Q000473:pathology / Q000532:radiotherapy*; D004285:Dogs; D005720:Gamma Rays; D006470:Hemorrhage / Q000473:pathology / Q000532:radiotherapy / Q000662:veterinary*; D008049:Lipase / Q000097:blood; D010179:Pancreas / Q000378:metabolism / Q000473:pathology; D010195:Pancreatitis / Q000473:pathology / Q000532:radiotherapy / Q000662:veterinary*; D014357:Trypsin / Q000378:metabolism
D008049:Lipase; D000681:Amylases; D014357:Trypsin