Effect of papaverine and atropine on pharmacokinetics of paracetamol administered orally.
The effect of intramuscular injection of atropine and papaverine on the pharmacokinetics of a single oral dose of paracetamol in healthy men was investigated. The open two-compartment model was applied and the calculations were performed using a program for the Hewlett-Packard 9830 B system. An increase of the extent of bioavailability of paracetamol was observed after the atropine administration, however the absorption of the drug was delayed. The administration of papaverine did not change the AUC and Cmax, but tmax was significantly longer.
D000082:Acetaminophen / Q000008:administration & dosage / Q000378:metabolism*; D000284:Administration, Oral; D000328:Adult; D001285:Atropine / Q000494:pharmacology*; D004347:Drug Interactions; D006801:Humans; D007700:Kinetics; D008297:Male; D008954:Models, Biological; D010208:Papaverine / Q000494:pharmacology*; D013997:Time Factors
D000082:Acetaminophen; D001285:Atropine; D010208:Papaverine