[Change in the nature of the persistence of alpha- and flaviviruses in the body of BALB/c strain mice with a mixed infection with leukovirus].
The features of pathogenesis of infection caused in adult Balb/c mice intraperitoneally infected with Sindbis virus, virulent or attenuated strains of West Nile (WN) virus, individually or in combination with Rauscher leukemia virus (RLV) were studied. The influence of the latter on the course of togavirus infections was characterized by 3 features: (a) different effects on the visceral and neural phases of the pathogenesis (increased period of viremia and virus reproduction in the viscera did not lead to stimulation of virus reproduction in the CNS); (b) changes in the time of togavirus persistence in the infectious form; (c) the dependence of the observed effect on the togavirus properties.
D000818:Animals; D001102:Arbovirus Infections / Q000382:microbiology* / Q000473:pathology; D005260:Female; D007942:Leukemia, Experimental / Q000382:microbiology* / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C / Q000382:microbiology*; D011925:Rauscher Virus / Q000472:pathogenicity; D012845:Sindbis Virus / Q000472:pathogenicity; D013997:Time Factors; D014762:Viral Interference; D014774:Virulence; D014779:Virus Replication; D014901:West Nile Fever / Q000382:microbiology* / Q000473:pathology; D014902:West Nile virus / Q000472:pathogenicity
Izmenenie kharaktera persistentsii al'fa- i flavivirusov v organizme mysheĭ linii BALB/c pri smeshannoĭ infektsii s leĭkovirusom.