Antiplatelet drugs and the generalized Shwartzman reaction in the pregnant rat.
Several antiplatelet drugs (aspirin, sulfinpyrazone, hydroxychloroquine, dipyridamole, BL-3459, pyridinolcarbamate) were assayed for their ability to prevent the generalized Shwartzman reaction initiated by endotoxin in the pregnant rat, and compared to glucocorticoids (dexamethasone, hydrocortisone). The drugs were administered in a single large dose a few hours before provocation of the reaction. In opposition to glucocorticoids and beside BL-3459 which interfere with other mechanisms involved in the phenomenon, the tested inhibitors of platelet aggregation were found incapable of preventing or reducing the severity of the Shwartzman reaction.
D000818:Animals; D001792:Blood Platelets / Q000187:drug effects*; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology; D010976:Platelet Count; D011247:Pregnancy; D011270:Pregnancy, Animal; D051381:Rats; D012790:Shwartzman Phenomenon / Q000097:blood / Q000188:drug therapy* / Q000473:pathology
D005938:Glucocorticoids