Interactions of La3+ with phosphatidylserine vesicles. Binding, phase transition, leakage and fusion.
The interaction of La3+ with phosphatidylserine vesicles is elucidated by binding studies, differential scanning calorimetry, X-ray diffraction, freeze fracture electron microscopy, and release of vesicle contents. La3+ effectively competes with Ca2+ for phosphatidylserine binding sites. The saturation level is close to a La/lipid ratio of 1:3. A concentration of 0.1 mM of La3+ is sufficient to induce fusion between sonicated vesicles.
D002152:Calorimetry, Differential Scanning; D055598:Chemical Phenomena; D002621:Chemistry; D005614:Freeze Fracturing; D007811:Lanthanum; D008854:Microscopy, Electron; D010718:Phosphatidylserines; D014961:X-Ray Diffraction
D010718:Phosphatidylserines; D007811:Lanthanum