The influx of tryptamine into snail (Helix pomatia) ganglia: comparison with 5-hydroxytryptamine.
Isolated ganglia possess the ability to concentrate tryptamine from an external medium by a process which is temperature sensitive and independent of sodium and other cations. Kinetic analysis of the accumulation process showed the influx of tryptamine to be a single mechanism with Km and Vmax values of 1.4 X 10(-4)M and 5 X 10(-8) mole/g/min. The influx of tryptamine is an unspecific process and is insensitive to a number of metabolic inhibitors and various analogues. The process of tryptamine influx is thus similar in principle to the low affinity uptake mechanism for 5-HT (see Osborne et al., 1975). The present data, which include some experiments on the release of 5-HT and tryptamine, are discussed from the point of view of a functional role for 5-HT and tryptamine in the snail CNS.
D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D002412:Cations / Q000494:pharmacology; D005724:Ganglia / Q000378:metabolism*; D006372:Helix, Snails / Q000378:metabolism*; D007700:Kinetics; D009474:Neurons / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism*; D013329:Structure-Activity Relationship; D014363:Tryptamines / Q000378:metabolism*
D002412:Cations; D014363:Tryptamines; D012701:Serotonin; D000255:Adenosine Triphosphate