[Insulin sensitivity of isolated muscle tissue of rats with manifest alloxan diabetes of different duration].
Insulin sensitivity of muscle tissue was assessed in 20 control rats and 27 rats with alloxan diabetes from the extent of its effect on C14-glucose incorporation by the diaphragmatic muscular glycogen. In diabetes of 5--8-day standing insulin sensitivity of muscle tissue remained unchanged. In alloxan diabetes of 22--24-day duration insulin sensitivity of muscle tissue diminished. With prolongation of decompensated alloxan diabetes up to 5--8 months a further decrease in incorporation of labelled glucose by the diaphragmatic glycogen was recorded. The data obtained indicate that metabolic disturbances inherent in diabetes mellitus lead to a decrease in insulin sensitivity of muscle tissue.
D000496:Alloxan; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D003964:Diaphragm / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D007328:Insulin / Q000378:metabolism*; D008297:Male; D051381:Rats; D013997:Time Factors
D007328:Insulin; D000496:Alloxan; D006003:Glycogen; D005947:Glucose
Chuvstvitel'nost' k insulinu izolirovannoĭ myshechnoĭ tkani krys s iavnym alloksanovym diabetom razlichnoĭ dlitel' nosti.