Radiation-induced fibrosarcoma of the mandible following treatment for bilateral retinoblastoma.
A case of fibrosarcoma of the mandible following radiotherapy for bilateral retinoblastoma and occurring in an 11-year-old female child is described. After a clinical description of the case, reported with histological documentation, problems connected with the pathogenesis of the malignancies are dealt with. Besides irradiation, genetic mutation as a carcinogenetic co-factor is taken into consideration.
D002648:Child; D005134:Eye Neoplasms / Q000532:radiotherapy; D005260:Female; D005354:Fibrosarcoma / Q000209:etiology*; D006801:Humans; D008339:Mandibular Neoplasms / Q000209:etiology*; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D011878:Radiotherapy / Q000009:adverse effects*; D012175:Retinoblastoma / Q000532:radiotherapy