Frozen conformers of clotrimazole: reaction of imadazole with 1-Chloro-9-hydroxy-9-phenylxanthene.
1-Chloro-9-hydroxy-9-phenylxanthene reacts with imidazole at 180 degrees to form a 5:1 mixture of the 9-(imidazo-1-yl)- and 9-(imidazo-2-yl)-1-chloro-9-phenylxanthenes. These products lack significant antifungal activity.
D055598:Chemical Phenomena; D002621:Chemistry; D003022:Clotrimazole / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D007093:Imidazoles / Q000138:chemical synthesis*; D008968:Molecular Conformation; D014966:Xanthenes
D007093:Imidazoles; D014966:Xanthenes; D003022:Clotrimazole