Agonistic properties of low doses of antifertility compounds in male rats.
Male Wistar Strain rats of known fertility were given subcutaneous dosage of three drugs, alpha-chlorohydrin, amino-alpha-chlorohydrin, and busulphan alone or in combination for a period of thirty days. Males were housed overnight with females at various times during the treatment and ninety days after cessation of treatment. There were significant differences in levels of glycerylphosphorylcholine in the epididymides of two treatment groups as well as differences in numbers of spermatozoa recovered from the reproductive tracts of female rats mated with males from four treatment groups. Treatment had no effect on the weights of the testes or sex accessory organs or sialic acid levels in the epididymis, fructose levels in dorso-lateral prostate and coagulating gland, or citric acid levels in seminal vesicle and ventral prostate of the treated males when compared to controls. The antifertility activity was probably mediated by an effect on epididymal spermatozoa and thereby subsequent change in sperm transport within the female genital tract.
D000818:Animals; D000988:Antispermatogenic Agents; D002066:Busulfan / Q000494:pharmacology*; D002728:Chlorohydrins / Q000494:pharmacology*; D004357:Drug Synergism; D005260:Female; D005298:Fertility / Q000187:drug effects*; D008297:Male; D011412:Propanolamines / Q000494:pharmacology*; D051381:Rats; D013081:Sperm Motility / Q000187:drug effects; D000517:alpha-Chlorohydrin / Q000031:analogs & derivatives / Q000494:pharmacology*
D000988:Antispermatogenic Agents; D002728:Chlorohydrins; D011412:Propanolamines; C009721:CL 88236; D000517:alpha-Chlorohydrin; D002066:Busulfan