[Cholesterol metabolism in liver at different levels of motor activity].
Biosynthesis and decomposition of cholesterol were studied in the rabbit liver under a dosed physical loading. Judging from the intensity of [2-14C]acetate incorporation, the cholesterol biosynthesis intensity rises during loading and decreases under conditions of limited mobility. The cholesterol content in the liver tissue of trained animals is unchanged and in animals, who were under conditions of limited mobility, it rises as compared with the control. Using [7-3N1] cholesterol as a substrate, it established that the activity of cholesterol-7 alpha-hydroxylase, as compared to the initial level, is increased under training and decreased under conditions of low mobility. The enzymic activity was determined by the amount of released 3H2O.
D000085:Acetates / Q000378:metabolism; D000818:Animals; D002784:Cholesterol / Q000096:biosynthesis / Q000378:metabolism*; D002790:Cholesterol 7-alpha-Hydroxylase / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D005082:Physical Exertion; D011817:Rabbits
D000085:Acetates; D002784:Cholesterol; D002790:Cholesterol 7-alpha-Hydroxylase
Obmen kholesterina v pecheni pri razlichnykh urovniakh dvigatel'noĭ aktivnosti.