Ethanol-induced prenatal growth deficiency: changes in fetal body composition.
Ethanol (6 g/kg/day) produced intrauterine growth retardation (both body weight and length) in rat fetuses compared to pair-fed controls. Associated with this retardation was an increase in fetal body water and sodium content and a decrease in lipid-free solid content. Comparable electrolyte changes were not observed in maternal blood. These effects in fetal body content are not commonly observed in fetal malnutrition studies and are suggestive of a direct teratogenic effect of ethanol.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004573:Electrolytes / Q000378:metabolism; D000431:Ethanol / Q000633:toxicity*; D005260:Female; D005317:Fetal Growth Retardation / Q000139:chemically induced*; D005333:Fetus / Q000187:drug effects / Q000378:metabolism*; D009929:Organ Size / Q000187:drug effects; D010920:Placenta / Q000187:drug effects; D011247:Pregnancy; D051381:Rats
D004573:Electrolytes; D000431:Ethanol