Dompamine receptors in the rat frontal cortex: an autoradiographic study.
Literature findings indicated that injection of low doses of [3H]spiperone results in a labelling of dopamine receptors in rat brain, but also in a labelling of serotonin receptors. Administration of pipamperone, a drug with serotonergic properties, to animals treated with [3H]spiperone reduced the serotonergic component of the binding and permitted an easier identification of dopamine receptor binding. At the level of Forceps Minor, there were elevated levels of receptors in the deeper layers of the cingulate cortex, in the region above the rhinal sulcus and in an area dorsal to the accumbens. This distribution is in agreement with the results of other biochemical, histochemical and electrophysiological studies.
D000818:Animals; D001345:Autoradiography; D001931:Brain Mapping; D005625:Frontal Lobe / Q000187:drug effects / Q000378:metabolism*; D006179:Gyrus Cinguli / Q000378:metabolism; D008032:Limbic System / Q000378:metabolism; D008297:Male; D010868:Pimozide / Q000494:pharmacology; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects / Q000378:metabolism*; D011985:Receptors, Serotonin / Q000187:drug effects / Q000378:metabolism; D012702:Serotonin Antagonists / Q000494:pharmacology; D013134:Spiperone / Q000378:metabolism
D011954:Receptors, Dopamine; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D010868:Pimozide; D013134:Spiperone