Comparative effects of imipramine and dothiepin on salivary rate in normal volunteers.
1 Imipramine induced significant reduction in salivary rate compared to placebo in a cross-over, double-blind study of twelve normal volunteers. In contrast, there was no significant difference between the reduction in salivary rate induced by dothiepin and placebo. 2 Comparison of salivary rates showed no significant difference between the drugs in the initial and cross-over treatment periods. However, pooled observations from the initial and cross-over treatment periods indicated that imipramine produced a significantly greater reduction in salivary rate than dothiepin. 3 The results suggest that dothiepin would cause far less dryness of mouth compared to imipramine. This feature might ensure greater therapeutic compliance.
D003988:Dibenzothiepins / Q000494:pharmacology*; D004308:Dothiepin / Q000494:pharmacology*; D004311:Double-Blind Method; D006801:Humans; D007099:Imipramine / Q000494:pharmacology*; D012472:Salivation / Q000187:drug effects*; D013997:Time Factors
D003988:Dibenzothiepins; D007099:Imipramine; D004308:Dothiepin