Dihydralazine and catecholamine-synthesizing enzymes in spontaneous hypertension.
Dihydralazine treatment which lowered blood pressure in young rats from the Lyon Hypertensive Strain (LHS), did not change phenylethanolamine-N-methyltransferase (PNMT) activity, but decreased tyrosine hydroxylase and dopamine-beta-hydroxylase activities in the C2 medullary region. These data suggest that the increase in PNMT activity, previously described for this strain, is not a consequence of the developing hypertension and that hypotensive treatment could inactivate some catecholaminergic neurons of the medulla oblongata.
D000313:Adrenal Medulla / Q000201:enzymology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002395:Catecholamines / Q000096:biosynthesis*; D004078:Dihydralazine / Q000494:pharmacology*; D005728:Ganglia, Sympathetic / Q000201:enzymology; D006830:Hydralazine / Q000031:analogs & derivatives*; D006973:Hypertension / Q000201:enzymology* / Q000503:physiopathology; D008297:Male; D008526:Medulla Oblongata / Q000201:enzymology; D051381:Rats; D013997:Time Factors
D002395:Catecholamines; D006830:Hydralazine; D004078:Dihydralazine