[Comparative characteristics of the antitumor and immunodepressive activity of carminomycin on the L-1210 experimental model].
The antitumor activity of carminomycin was estimated by the number of lymphoma colonies formed in the spleen of DBA/2 mice on their inoculation with the bone marrow cells from mice with transplantable leukemia L-1210. The immunodepressive properties of carminomycin were determined by the number of the antibody forming cells in the spleen of CBA and DBA/2 mice with leukemia L-1210 after immunization with sheep red blood cells. It was found that in a single dose of 1.5 mg/kg carminomycin inhibited the lymphoma colonies by 50 per cent. The maximum immunodepressive effect was observed when carminomycin was used in a single dose of 1.5 mg/kg 48 hours after the antigen stimulation. In this case the number of the antibody forming cells in DBA/2 mice with leukemia L-1210 was lower than that in CBA mice without leukemia.
D000818:Animals; D000903:Antibiotics, Antineoplastic; D002360:Carubicin / Q000627:therapeutic use*; D003630:Daunorubicin / Q000031:analogs & derivatives*; D004305:Dose-Response Relationship, Drug; D007109:Immunity; D007114:Immunization; D007166:Immunosuppressive Agents; D007939:Leukemia L1210 / Q000188:drug therapy* / Q000276:immunology; D051379:Mice; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D009368:Neoplasm Transplantation; D013997:Time Factors
D000903:Antibiotics, Antineoplastic; D007166:Immunosuppressive Agents; D002360:Carubicin; D003630:Daunorubicin
Sravnitel'naia kharakteristika protivoopukholevoĭ i immuno-depressivnoĭ aktivnostikarminomitsina na éksperimental'noĭ modeli L-1210.