title: Synthesis of new mercaptotriazoles with potential antibilharzial activity.
abstract: Several 3-mercaptotriazoles with the 8-hydroxyquinoline moiety in the 5-position were prepared and tested for antiparasitic activity. Preliminary biological tests on experimentally infected mice with Schistosoma mansoni worms revealed that the new compounds possess potent schistosomicidal activity.
mesh_terms: D000818:Animals; D001921:Brain / Q000469:parasitology; D055598:Chemical Phenomena; D002621:Chemistry; D007422:Intestines / Q000469:parasitology; D051379:Mice; D012547:Schistosoma / Q000187:drug effects; D012550:Schistosoma mansoni / Q000187:drug effects; D012552:Schistosomiasis / Q000188:drug therapy; D012556:Schistosomicides / Q000138:chemical synthesis*; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis*; D014120:Toxocariasis / Q000188:drug therapy; D014230:Triazoles / Q000138:chemical synthesis*
chemical_list: D012556:Schistosomicides; D013438:Sulfhydryl Compounds; D014230:Triazoles