title: A short-term test to predict acceptable levels of exposure to airborne sensory irritants.
abstract: An animal model has been developed using decrease in respiratory rate in mice as an index of sensory irritation. Concentration-response relationships were developed for 11 sensory irritants. The RD50, defined as the concentration associated with a 50% decrease in respiratory rate, has been shown to have a predictable relationship to sensory irritation in man. By extending the accepted toxicological principle that the ratio lethal/toxic/effective/ineffective/acceptable in diet is 10/1/10(-1)/10(-2)/10(-3) dosage units to air concentrations, exposure guidelines can be proposed for TLVs, STELs, etc.
mesh_terms: D000393:Air Pollutants; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004781:Environmental Exposure; D007509:Irritants / Q000494:pharmacology; D008297:Male; D008452:Maximum Allowable Concentration; D008722:Methods; D051379:Mice; D012119:Respiration / Q000187:drug effects
chemical_list: D000393:Air Pollutants; D007509:Irritants