Renal lymph and interstitial fluid concentration of co-trimazine: an experimental study in dogs.
Renal clearance and renal hilar lymph and interstitial fluid concentrations of co-trimazine were investigated in dogs during constant intravenous infusion. The lymph was obtained by direct cannulation of the lymphatics, and the interstitial fluid from small plastic tissue chambers, implanted 4--6 weeks before the experiments. The clearance values for trimethoprim and sulphadiazine, compared to the glomerular filtration rate, as measured by 125I-iothalamate clearance, showed a net tubular secretion of trimethoprim and tubular re-absorption of sulphadiazine. Renal lymph and interstitial fluid concentrations were found to be lower than the plasma concentrations, corresponding well with earlier findings for several other antimicrobial agents. We found a statistically significant difference between lymph/plasma and interstitial fluid/plasma ratios, indicating different composition and origin of lymph and interstitial fluid.
D000818:Animals; D004285:Dogs; D004338:Drug Combinations; D005110:Extracellular Space / Q000032:analysis; D005919:Glomerular Filtration Rate; D007275:Injections, Intravenous; D007668:Kidney / Q000032:analysis*; D007700:Kinetics; D008196:Lymph / Q000032:analysis; D013411:Sulfadiazine / Q000097:blood / Q000494:pharmacology*; D014295:Trimethoprim / Q000097:blood / Q000494:pharmacology*
D004338:Drug Combinations; D013411:Sulfadiazine; D014295:Trimethoprim