title: Effects of prostaglandins on coronary flow rate and left ventricular work in isolated rat heart.
abstract: In isolated rat hearts PGD2, PGE1, PGE2, PGF2 alpha and PGI2 increased coronary flow rate at concentrations of about 23, 1.4, 0.4, 2.5 and 0.6 nmol per l respectively. PGD2, PGE2, and PGI2 did not affect left ventricular work (W 1v). PGE1 (14 nmol/l) lowered W 1v (12% and PGF2 alpha (9 nmol/l) increased W 1v (10%). It is concluded that endogenously released PGI2 can probably affect coronary flow rate.
mesh_terms: D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects*; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects*; D011453:Prostaglandins / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors; D016276:Ventricular Function
chemical_list: D011453:Prostaglandins