Relative extents of hydrogen-deuterium exchange of nitrosamines: relevance to biological isotope effect studies.
Relative extents of base-catalyzed, hydrogen-deuterium exchange have been determined for a number of nitrosamines. Observed trends in the exchanges are discussed in terms of substitution, ring size and conformation. The relevance of the exchanges to deuterium isotope effects in carcinogenesis tests is discussed. Those compounds which give pronounced biological isotope effects undergo exchange only to a small extent. No biological isotope effect is found for compounds which undergo extensive exchange.
D000818:Animals; D003903:Deuterium; D006859:Hydrogen; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009602:Nitrosamines; D011522:Protons; D013329:Structure-Activity Relationship
D009602:Nitrosamines; D011522:Protons; D006859:Hydrogen; D003903:Deuterium