Reactivity of normotensive and spontaneously hypertensive rats (SHR) to some antihypertensive agents after acute and chronic treatment.
Hypotensive action of some antihypertensive agents was studied on normotensive and spontaneously hypertensive rats in acute and chronic treatment. The reactivity of normotensive rats was much more weaker than in rats with spontaneous hypertension (SHR). Results of the experiments indicate also that the selection of new antihypertensive agents should be based on tests carried out with at least two models of hypertension.
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006852:Hydrochlorothiazide / Q000494:pharmacology; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D008750:Methyldopa / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D051381:Rats; D013997:Time Factors; D014032:Todralazine / Q000494:pharmacology
D000959:Antihypertensive Agents; D006852:Hydrochlorothiazide; D008750:Methyldopa; D014032:Todralazine; D010646:Phentolamine