Influence of anaesthetic agents on the survival of rats following acute ischaemia of the bowel.
We compared the effects of ketamine and halothane anaesthesia on the survival of rats subjected to superior mesenteric artery occlusion. Survival was significantly greater with halothane. Animals anaesthetized with ketamine developed arterial hypocarbia during bowel ischaemic shock, while those receiving halothane did not. Arterial hypoxaemia was not present in either group. Haematocrits increased in both groups following bowel ischaemia. Excess lactate was increased significantly in non-survivors compared with survivors. The survival data contrast with previous results obtained after haemorrhagic hypotension and emphasize the need to consider differing therapeutic approaches in the various shock states.
D000769:Anesthesia, Inhalation; D000771:Anesthesia, Intravenous; D000818:Animals; D001794:Blood Pressure; D002245:Carbon Dioxide / Q000097:blood; D006221:Halothane; D007422:Intestines / Q000098:blood supply; D007511:Ischemia / Q000150:complications / Q000209:etiology; D007649:Ketamine; D007773:Lactates / Q000097:blood; D008297:Male; D008638:Mesenteric Arteries; D008641:Mesenteric Vascular Occlusion / Q000150:complications*; D010313:Partial Pressure; D051381:Rats; D012769:Shock / Q000209:etiology / Q000401:mortality*
D007773:Lactates; D002245:Carbon Dioxide; D007649:Ketamine; D006221:Halothane