title: Uveal malignant melanoma in three generations of the same family.
abstract: Three patients in three successive generations from the same family had choroidal malignant melanoma. The third generation patient had multiple primary malignancies; his siblings also had multiple malignancies. Chromosome studies of the third generation patient revealed no abnormality. To the best of our knowledge, this is the second such pedigree reported.
mesh_terms: D000328:Adult; D000368:Aged; D005134:Eye Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000235:genetics* / Q000473:pathology; D009378:Neoplasms, Multiple Primary / Q000235:genetics / Q000473:pathology; D010375:Pedigree; D014603:Uveal Diseases / Q000235:genetics* / Q000473:pathology