title: [Differentiation of mesothelial cells during their reparative regeneration].
abstract: The investigation on regenerative processes of mesothelium of the parietal peritoneum was performed in 120 white mice under the effect of certain irritants producing lesions various in depth and intensity. Nuclear-cytoplasmic relations and ultramicroscopic cellular rearrangement were studied during the process of differentiation of the mesothelial regenerate. Two periods of the regenerative process are stated and it is demonstrated that rearrangement of the mesothelial cells and the mode of their division depend on intensity of the lesions. When the peritoneal lesion is severe, at the first stages of regeneration (the 1st period) rearrangement of cells towards their hypertrophy and increased functional activity is predominant in the mesothelium. Further (the 2d period), the number of mitotically dividing cells is increasing in the mesothelial regenerate and in rearrangement of the mesothelial cells the processes connected with a partial loss of their signs of specialization predominate. The transition from one period into another is gradual and duration of each depends on intensity of the lesion.
mesh_terms: D000818:Animals; D002452:Cell Count; D002454:Cell Differentiation; D006851:Hydrochloric Acid / Q000009:adverse effects; D008297:Male; D051379:Mice; D008854:Microscopy, Electron; D008938:Mitosis; D009940:Organoids / Q000648:ultrastructure; D010537:Peritoneum / Q000293:injuries* / Q000648:ultrastructure; D013997:Time Factors; D014945:Wound Healing
chemical_list: D006851:Hydrochloric Acid
vernacular_title: Differentsirovka kletok mezoteliia pri ego reparativnoĭ regeneratsii.