Blunting of exercise-induced tachycardia and renin release 24 hours after a single dose of sotalol.
Sotalol significantly reduces resting and exercise-stimulated heart rate and plasma renin activity 2 hours and to a lesser degree also 24 hours after oral administration of a single 200-mg dose in healthy volunteers. Because of this 24-hour beta-adrenoceptor blocking effect, sotalol should be suitable for once-daily dosing in clinical practice.
D000328:Adult; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008297:Male; D005082:Physical Exertion / Q000187:drug effects*; D012083:Renin / Q000097:blood*; D012146:Rest; D013015:Sotalol
D013015:Sotalol; D012083:Renin