title: Attenuation of saccharin neophobia by melatonin.
abstract: Administration of Melatonin has been reported to decrease emotionality in the rat as indexed by the defecation response. The present experiment was designed to examine whether Melatonin would attenuate the neophobic response to a novel solution. It was found that Melatonin significantly increased the rat's consumption of a novel saccharin solution suggesting that the emotionality/arousal produced by the intake of this solution was attenuated.
mesh_terms: D000818:Animals; D001143:Arousal / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects*; D003672:Defecation / Q000187:drug effects; D004327:Drinking Behavior / Q000187:drug effects; D004644:Emotions / Q000187:drug effects*; D008297:Male; D008550:Melatonin / Q000494:pharmacology*; D051381:Rats; D012439:Saccharin; D013997:Time Factors
chemical_list: D012439:Saccharin; D008550:Melatonin