[The influence of ethanol, dithiocarb, diethylmaleate and phenobarbital on the metabolic elimination of halothane in rats (author's transl)].
Rats exposed to halothane (100 ppm) in a closed allglass-system eliminate halothane from the atmosphere of this system with a half-life (t0.5) of 0.99 h. In 24 h-fasted rats t0.5 was prolonged to 1.24 h. A single oral load of 4.8 g/kg ethanol as well as a 15% ethanol solution instead of drinking water for 28 days did not alter the metabolic elimination of halothane. On the other hand, ethanol (4.8 g/kg p.o.) applied 5 min before exposure to halothane markedly prolonged t0.5 to 3.79 h. Pretreatment with phenobarbital (80 mg/kg i.p. for 4 days) shortened t0.5 significantly to 0.79 h. Inhibition of the mixed-function oxidase system by dithiocarb (100 mg/kg i.p.) or diethyl maleate (1 ml/kg i.p.) markedly prolonged t0.5 to 7.53 and 1.57 h. respectively. The observed modifications of the halothane metabolism may be of interest in relation to the problem of halothane-induced hepatotoxicity.
D000818:Animals; D000431:Ethanol / Q000494:pharmacology; D006221:Halothane / Q000378:metabolism*; D008298:Maleates / Q000494:pharmacology; D008657:Metabolic Clearance Rate / Q000187:drug effects*; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D013859:Thiocarbamates / Q000494:pharmacology
D008298:Maleates; D013859:Thiocarbamates; D000431:Ethanol; D006221:Halothane; D010634:Phenobarbital
Einfluss von Athanol, Dithiocarb, Diäthylmaleat und Phenobarbital auf die metabolische Elimination von Halothan bei Ratten.