title: Randomized prospective matched pair study comparing peritoneovenous shunt and conventional therapy in massive ascites.
abstract: A prospective randomized matched pair study was designed to test the efficacy of the peritoneovenous (LeVeen) shunt as a treatment for massive cirrhotic ascites compared with traditional medical therapy. Patients who failed to lose weight while on a low salt diet and fluids restricted to 1000 ml daily were placed in the study group. Weight loss, decrease in abdominal girth and diuresis were significantly greater (P less than 0.01) for surgical patients than for their medically treated counterparts. The surgical technique is simple, quick and inexpensive. The surgical patients outlived their matched partners in 12 of 14 pairs where a definitive comparison was possible (P less than 0.02). The median stay in hospital after randomization was shortened from 32 days with medical therapy to 15 days for those undergoing the shunt operation. Those treated medically experienced a significant rise in mean blood urea nitrogen and K+ (P less than 0.02). Patients with alcoholic hepatitis, hyperbilirubinaemia (bilirubin greater than 154 mumol/l), peritoneal sepsis, severe coagulopathy and those who had recently bled from oesophageal varices are poor risks for the surgical procedure.
mesh_terms: D001201:Ascites / Q000601:surgery / Q000628:therapy*; D004039:Diet, Sodium-Restricted; D004232:Diuretics / Q000627:therapeutic use*; D006801:Humans; D008103:Liver Cirrhosis / Q000601:surgery / Q000628:therapy; D008722:Methods; D010537:Peritoneum / Q000601:surgery*; D011446:Prospective Studies; D011897:Random Allocation; D014683:Vena Cava, Superior / Q000601:surgery*
chemical_list: D004232:Diuretics