[Effect of cytidine and uridine on liver regeneration in rats poisoned by carbon tetrachloride].
The effect of cytidine and uridine on the reparative processes in the rat liver in experimental hepatitis induced by CCl was studied. Combined administration of uridine or cytidine with CCl4 during 7 days does not prevent the liver affection. The subsequent nucleoside treatment (up to 15 and 20 days) accelerates to a different degree the reparative processes after CCl4 withdrawal. Thus, cytidine provokes marked hypertrophy of regenerated hepatocytes accompanied by proliferation of the mesenchymal elements, not followed, however, by recovery of the conjugative and excretory liver functions. Uridine, in contrast to cytidine, promotes more rapid normalization of these functions though the organ structure regeneration is not complete.
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000503:physiopathology*; D003562:Cytidine / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000503:physiopathology; D008115:Liver Regeneration / Q000187:drug effects*; D008297:Male; D051381:Rats; D013268:Stimulation, Chemical; D013997:Time Factors; D014529:Uridine / Q000494:pharmacology*
D003562:Cytidine; D014529:Uridine
Vliianie tsitidina i uridina na regeneratsiiu pecheni u krys pri otravlenii chetyrekhkhloristym uglerodom.