[Inhibition of concanavalin A and phytohemagglutinine P mediated agglutination of L 1210 cells by different azomethines and possible relations to their cytostatic activity (author's transl)].
Compounds of a special azomethine type have been tested on their activity against concanavalin A and phytohemagglutinine P mediated agglutination of leukemia L 1210 cells. With exception of two compounds possessing a bis-(beta-hydroxyethyl) amino group at the phenyl moiety in para-position to the azomethine group all substances considerable inhibited agglutination of L 1210 cells. In vitro active concentrations are also obtained in animal experiments at least for a short time at the site of injection (i.p.) The importance of cellular reactions for effectivity in vivo is discussed.
D000371:Agglutination / Q000187:drug effects*; D000818:Animals; D003208:Concanavalin A / Q000494:pharmacology; D005260:Female; D066298:In Vitro Techniques; D007939:Leukemia L1210 / Q000188:drug therapy*; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation; D010835:Phytohemagglutinins / Q000494:pharmacology; D012545:Schiff Bases / Q000494:pharmacology* / Q000627:therapeutic use
D010835:Phytohemagglutinins; D012545:Schiff Bases; D003208:Concanavalin A
Hemmung der durch Concanavalin A und Phytohämagglutinin P vermittelten Agglutination von L 1210-Zellen mit verschiedenen Azomethinen und mögliche Beziehungen zu deren zytostatischer Wirksamkeit.