title: Influence of immersion to the neck in water on airway closure and distribution of perfusion in man.
abstract: We measured closing volume (CV), expiratory reserve volume (ERV) regional distribution of lung volume (Vr) and perfusion in 7 normal subjects in air and during immersion to the neck in water. In four subjects immersion resulted in a CV greater than ERV and the normal perfusion distribution became inverted. In the other subjects, ERV remained larger than CV and perfusion distribution during immersion was uniform, not inverted. In 5 subjects closing volume increased and in 3 of them, the ratio of apical/basal Vr increased significantly during immersion. One subject had nomeasurable CV and in the other it was not measured. The data suggest: (1) that when CV is greater than ERV during immersion there is an inversion of the normal perfusion distribution, caused by hypoxia and/or an increase in mean alveolar pressure in the alveoli beyond the closed airways, and (2) that an increase in pleural pressure gradient during immersion may contribute to the increase in C.V.
mesh_terms: D000293:Adolescent; D000328:Adult; D005105:Expiratory Reserve Volume; D005260:Female; D006801:Humans; D007101:Immersion / Q000503:physiopathology*; D008168:Lung / Q000502:physiology; D008176:Lung Volume Measurements; D008297:Male; D012115:Residual Volume; D012119:Respiration