[Intracellular and extracellular alkaloids of Penicillium roqueforti].
The alkaloid composition of mycelium and culture liquid filtrate of the fungus Penicillium roqueforti IBPM-F-141 was studied. The new metabolite--3,12-dihydroroquefortine, a derivative of roquefortine, the main component of the alkaloid fraction of this culture, has been isolated for the first time. The structure of 3,12-dihydroroquefortine was determined by chemical and physico-chemical methods. In addition to roquefortine and 3,12-dihydroroquefortine, representatives of a new alkaloid group, the clavine alkaloids, e. g. isofumigaclavine A, isofumigaclavine B and festuclavine, were also isolated and identified. The data on the content of these compounds in mycelium and culture medium are presented.
D000470:Alkaloids / Q000032:analysis*; D002849:Chromatography, Gas; D004873:Ergolines; D013058:Mass Spectrometry; D010407:Penicillium / Q000032:analysis*; D013329:Structure-Activity Relationship
D000470:Alkaloids; D004873:Ergolines; C021178:3,12-dihydroroquefortine
Vnutri-i Vnekletochnye alkaloidy Penicillium roqueforti.