[Survival of the mutant clone. III. Catastrophic selection. The inadequacy of the selection coefficient for assessing clone fate].
Majorant estimations of the probabilities pr for the surviving of the clone of the dividing cells have been obtained in the catastrophic situation (monotonous diminishing of the clone almost to zero during the period of time from t=0 to t=T, T approximately 100 generation). At t=0 the clone consisted of 10(6) individuals. Average selection coefficient (s) was found to determine pr only roughly, that is the clone with s greater than --0.09 survives almost in all cases, whereas the clone with s greater than --0.13 becomes extinct practically always. Within this interval ps-inversion can be observed, i.e. preferential surviving of the clone with a worse s value. Results of three communications lead to the conclusion that the mutants with small selective advantage practically cannot be selected.
D002470:Cell Survival; D002999:Clone Cells / Q000166:cytology*; D008433:Mathematics; D009154:Mutation; D011336:Probability; D012641:Selection, Genetic
Vyzhivanie mutantnogo klona. Soobshchenie III. Katastroficheskii otbor. Nedostatochnost' koéffitsienta otbora dlia otsenki sud'by klona.