title: The failure of trichothecene mycotoxins and whole cultures of Fusarium tricinctum to cause experimental haemorrhagic syndromes in calves and pigs.
abstract: Piglets and calves were dosed orally with pure diacetoxyscirpenol (DAS) and T-2 toxin, crude extracts of Fusarium tricinctum containing T-2 toxin, and whole cultures of F tricinctum containing T-2 toxin at a constant daily rate of 0.1 mg toxin per kg body-weight (piglets) or 0.2 mg toxin per kg body-weight (calves). The treatment continued for periods of seven to 78 days but it failed to induce clinical haemorrhagic syndromes. Increasing the dose of F tricinctum culture five-fold for eight days following 78 days at the lower dose was equally ineffective. The lack of an effect by daily intakes of toxin that could have been ingested with naturally contaminated feedstuffs suggests that DAS, T-2 toxin and other metabolites of F tricinctum probably have little or no part to play in the aetiology of feed associated haemorrhagic disease.
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood / Q000139:chemically induced*; D005670:Fusarium; D006470:Hemorrhage / Q000097:blood / Q000139:chemically induced / Q000662:veterinary*; D012717:Sesquiterpenes / Q000633:toxicity*; D013552:Swine; D013553:Swine Diseases / Q000097:blood / Q000139:chemically induced*; D013605:T-2 Toxin / Q000633:toxicity*; D014255:Trichothecenes / Q000633:toxicity*
chemical_list: D012717:Sesquiterpenes; D014255:Trichothecenes; D013605:T-2 Toxin; C001809:diacetoxyscirpenol