Repeated abortions and histocompatibility antigens. Can HLA antigen restricted gene dose effects influence the feto-maternal relationship?
It is suggested that the induction of cytotoxic reactions in the mother by allogeneic fetal cells is HLA antigen restricted and influenced, in certain haplotype combinations, by gene dose effects of specific HLA antigens (locus A and B), shared by the fetus and by the mother. The possibility that alloimmunization of maternal cells to fetal transplantation antigens may have beneficial or adverse effects on the fetal target cells dependent upon feto-maternal histocompatibility antigen interrelationship would provide a new approach for interpreting functional disturbances in certain cases of human pregnancy.
D000022:Abortion, Spontaneous / Q000235:genetics* / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D005260:Female; D005796:Genes; D005838:Genotype; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology*; D006801:Humans; D008297:Male; D008431:Maternal-Fetal Exchange; D010641:Phenotype; D011247:Pregnancy; D012008:Recurrence; D012306:Risk; D012641:Selection, Genetic
D006680:HLA Antigens