Chloroquine ototoxicity--a reversible phenomenon?
The case of a six-year-old girl suffering from severe cochleo-vestibular dysfunction following a series of chloroquine phosphate injections is presented in this paper. Prompt institution of therapy with steroids and vaso-dilators has helped to restore the hearing to a serviceable (socially acceptable) level. A surmise is made about the pathogenesis of chloroquine ototoxicity and how prompt appropriate therapy may be able to reverse the process. A plea is made for early referral of these cases so that prompt attention may be paid to them.
D002648:Child; D002738:Chloroquine / Q000009:adverse effects*; D004338:Drug Combinations; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced* / Q000188:drug therapy; D006801:Humans; D011239:Prednisolone / Q000627:therapeutic use; D014801:Vitamin A / Q000627:therapeutic use; D014810:Vitamin E / Q000627:therapeutic use
D004338:Drug Combinations; D014801:Vitamin A; D014810:Vitamin E; D002738:Chloroquine; D011239:Prednisolone