Histological characteristics of the human testis after long-term treatment with cyproterone acetate.
Cyproterone acetate, an antiandrogen drug, is used to reduce mammalian fertility. Effects on the human testis are controversial. Findings in this study reveal that long-term treatment-7 months with 200 mg/day-leads to disappearance of the germinal cells and to Sertoli cells with either a normal or undifferentiated aspect as well as involution of the Leydig cell. Some pathogenetic hypotheses on the action of cyproterone acetate upon human spermatogenesis are discussed.
D003534:Cyproterone / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007985:Leydig Cells / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000188:drug therapy; D012708:Sertoli Cells / Q000187:drug effects; D013737:Testis / Q000166:cytology / Q000187:drug effects*
D003534:Cyproterone