[Role of serotoninergic mechanisms in realizing the influence of diazepam on the effect of self-stimulation].
It has been shown in experiments on rats that diazepam (I mg/kg) abolishes an inhibitory action of cytalopram, the serotonine reverse uptake inhibitor (10 mg/kg) on the self-stimulation effect. Activation of self-stimulation was observed during diazepam action and in the presence of a decrease in the activity of serotoninergic processes, that was achieved by parachloramphetamine administration in doses of 5 and 15 mg/kg. It is concluded that the activating effect of diazepam is not mediated through the serotoninergic systems of the brain.
D000818:Animals; D001572:Benzofurans / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology*; D004347:Drug Interactions; D004558:Electric Stimulation; D011437:Propylamines / Q000494:pharmacology; D051381:Rats; D011985:Receptors, Serotonin / Q000187:drug effects*; D012054:Reinforcement, Psychology; D012653:Self Stimulation / Q000187:drug effects*; D012702:Serotonin Antagonists / Q000494:pharmacology; D013997:Time Factors; D010133:p-Chloroamphetamine / Q000494:pharmacology
D001572:Benzofurans; D011437:Propylamines; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D010133:p-Chloroamphetamine; D003975:Diazepam
Rol' serotoninergicheskikh mekhanizmov v realizatsii vliianiia diazepama na éffekt samostimuliatsii.