title: Alterations of estrogen metabolism in systemic lupus erythematosus.
abstract: Estradiol metabolism in 10 patients with systemic lupus erythematosus (SLE) and 29 normal controls was studied by measurement of urinary metabolites after injection of labeled 3H-estradiol. Patients with SLE manifested increased 16-hydroxylation of estrone. Diseases men differed from diseases women to the extent that only 16 alpha-hydroxyestrone was elevated in men, whereas women had elevations of both 16 alpha-hydroxyestrone and estriol. These data suggest that patients with SLE have abnormal patterns of estradiol metabolism, leading to increased estrogenic activity.
mesh_terms: D000293:Adolescent; D000328:Adult; D004958:Estradiol / Q000652:urine; D004964:Estriol / Q000652:urine; D004967:Estrogens / Q000652:urine*; D004970:Estrone / Q000031:analogs & derivatives / Q000652:urine; D005260:Female; D006801:Humans; D006894:Hydroxyestrones / Q000652:urine; D008180:Lupus Erythematosus, Systemic / Q000652:urine*; D008297:Male; D008875:Middle Aged
chemical_list: D004967:Estrogens; D006894:Hydroxyestrones; D004970:Estrone; D004958:Estradiol; D004964:Estriol