Recovery of immune responsiveness to rabies vaccine after treatment of mice with cyclophosphamide.
Mice treated with cyclophosphamide (Cy) recovered the ability to mount delayed type hypersensitivity reactions within 3 days. By contrast, antibody production to a T cell independent antigen (E. coli lipopolysaccharide) and to human diploid cell strain rabies vaccine did not occur unless the immunization of Cy-treated mice was delayed for 7-10 days. No significant resistance to rabies infection was recorded at 10 days but was demonstrable if 14 days had elapsed between Cy treatment and vaccination.
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D000917:Antibody Formation; D003520:Cyclophosphamide / Q000494:pharmacology*; D006968:Hypersensitivity, Delayed; D008070:Lipopolysaccharides / Q000276:immunology; D008297:Male; D051379:Mice; D011819:Rabies Vaccines / Q000276:immunology*; D011820:Rabies virus / Q000276:immunology; D013997:Time Factors
D000914:Antibodies, Viral; D008070:Lipopolysaccharides; D011819:Rabies Vaccines; D003520:Cyclophosphamide