The rate of sister chromatid exchange in normal human bone marrow cells.
Sister chromatid exchange (SCE) was studied in bone marrow cells of six healthy individuals. Compared with peripheral blood lymphocytes, a remarkably low and constant rate of SCEs was observed, ranging from 3.64 to 4.65 per metaphase. The lower incidence of SCE can be related only partly to the higher contraction of bone marrow cells and the shorter exposure time to BUdR. Rather, a cell-specific phenomenon is suggested.
D000328:Adult; D001853:Bone Marrow / Q000648:ultrastructure*; D001973:Bromodeoxyuridine / Q000494:pharmacology; D002875:Chromosomes / Q000648:ultrastructure*; D003434:Crossing Over, Genetic; D004305:Dose-Response Relationship, Drug; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure; D008297:Male; D012854:Sister Chromatid Exchange; D013997:Time Factors
D001973:Bromodeoxyuridine