[Sympathetic-adrenal and enterochromaffin systems and homeostatic indices in open-heart surgical operations under morphine anesthesia].
Catecholamine, serotonin and histamine metabolism and the level of acid metabolites and the activity of the enzymes lactate dehydrogenase and catalse in blood were studied in patients with congenital heart disease who were operated on under conditions of extracorporeal circulation and morphine anesthesia. The results obtained were compared with the values of acid-base balance, haemodynamics and volume of diuresis. It wwas found that the period of morphine induction was marked by a significant increase in the blood plasma noradrenalin content in the absence of essential changes in the other biochemical and hemodynamic indices studied. No significant changes were noted in the systems of neurohumoral and tissue regulation, indices of the redox processes and renal excretion in the most traumatic periods of the operation. The data obtained allow morphine to be accepted as an anesthetic which provides adequate protection of the organism from operative trauma.
D000293:Adolescent; D000311:Adrenal Glands / Q000187:drug effects*; D000328:Adult; D000698:Analgesia / Q000379:methods; D000771:Anesthesia, Intravenous; D006348:Cardiac Surgical Procedures; D002838:Chromaffin System / Q000187:drug effects*; D005260:Female; D006343:Heart Septal Defects / Q000601:surgery; D006706:Homeostasis / Q000187:drug effects*; D006801:Humans; D008297:Male; D009020:Morphine; D011229:Preanesthetic Medication; D013564:Sympathetic Nervous System / Q000187:drug effects*
D009020:Morphine
Simpatiko-adrenalovaia, énterokhromaffinnaia sistemy i nekotorye pokazateli gomeostaza pri kardiokhirurgicheskikh operatsiiakh na otkrytom serdtse v usloviiakh anestezii morfinom.