Vascular smooth muscle: aerobic glycolysis linked to sodium and potassium transport processes.
Under aerobic conditions, glucose is primarily catabolized by vascular smooth muscle to lactate, in spite of an adequate oxidative capacity. Although this is often considered to be indicative of some nonspecific metabolic insufficiency, there is evidence that aerobic glycolysis is specifically coupled to sodium and potassium transport processes, whereas oxidative metabolism is couple to contracticle energy requirements.
D000332:Aerobiosis; D000818:Animals; D001158:Arteries / Q000378:metabolism*; D001693:Biological Transport, Active / Q000187:drug effects; D006019:Glycolysis / Q000187:drug effects; D007773:Lactates / Q000378:metabolism; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000378:metabolism*; D010042:Ouabain / Q000494:pharmacology; D010101:Oxygen Consumption / Q000187:drug effects; D011188:Potassium / Q000378:metabolism* / Q000494:pharmacology; D012964:Sodium / Q000378:metabolism*
D007773:Lactates; D010042:Ouabain; D012964:Sodium; D011188:Potassium