title: [Pituitary microadenoma of Cushing's disease. Course following transsphenoidal excision. Four cases (author's transl)].
abstract: Transsphenoidal microsurgery was performed in four patients with a pituitary microadenoma who presented Cushing's disease. Preoperative features were the following: 1) Clinical and laboratory signs of hypercortisolism 2) No radiological evidence of an adrenal tumor 3) Normal or increased ACTH plasma levels 4) Sellar tomograms suggesting the presence of a pituitary microadenoma in only one case. Postoperative outcome after 3 to 30 months follow-up showed persistence or even improved reactivity of the various pituitary functions and especially the early occurence of corticotropin deficiency in all 4 patients. This isolated deficiency regressed spontaneously after 6 and 12 months (2/4 cases). Twenty-four hour studies of ACTH and cortisol profiles and dexamethasone suppression as well as response to metyrapone confirmed the resumption of physiological corticotropin regulation.
mesh_terms: D000236:Adenoma / Q000150:complications* / Q000601:surgery; D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000378:metabolism; D000328:Adult; D003480:Cushing Syndrome / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010902:Pituitary Gland / Q000503:physiopathology; D010911:Pituitary Neoplasms / Q000150:complications* / Q000601:surgery
chemical_list: D000305:Adrenal Cortex Hormones
vernacular_title: Microadénomes hypophysaires lors de maladies de Cushing. Evolution après exérèse transsphénoïdale. 4 observations.