Feeding and depression of abomasal secretion in sheep elicited by elfazepam and 9-aza-cannabinol.
Elfazepam (7-chloro-1-[2-(ethylsulfonyl)ethyl]-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4benzodiazepin-2-one) and-9-aza-cannabinol )10 hydroxy-beta-(3-methyl-2-octyl)-5',5-dimethyl-5H-1 benzopyranol 3,4-d pyridine, HC1) were administered IV to study their effects on feed intake and acid secretion in abomasal Pavlov pouches in sheep. Elfazepam and 9-aza-cannabinol increased 3-fold 3 hr postinjection feed intake and decreased abomasal acid secretion compared to saline and DMSO (dimethyl sulfoxide) control treatments. At doses which elicit feeding, 9-aza-cannabinol was a much more potent inhibitor of acid secretion than elfazepam. These results are consistent with the theory of localized hypothalamic nuclei which have roles in the control of both feed intake and gastric acid secretion. However, in contrast to feeding associated with normal hunger, the benzodiazepine and cannabinol stimulated feeding is associated with decreased gastric acid secretion.
D000018:Abomasum / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D001570:Benzodiazepinones / Q000494:pharmacology*; D002186:Cannabinoids / Q000494:pharmacology*; D002187:Cannabinol / Q000031:analogs & derivatives / Q000494:pharmacology*; D003864:Depression, Chemical; D004435:Eating / Q000187:drug effects*; D012756:Sheep; D013997:Time Factors
D001570:Benzodiazepinones; D002186:Cannabinoids; D002187:Cannabinol; C019364:elfazepam