Induction of cataracts in the rat by derivatives of (4' -pyridyl) - 1 piperazine.
A structure ocular toxicity study in the rat of (4' - pyridyl) - 1 piperazine and of some derivatives with psychopharmacological profile, allows some interesting conclusions. (4' - pyridyl) - 1 piperazine does not lead to crystalline lens opacity, though some aryloxypropanol or aryloxypropyl derivatives do. At least, (2' - pyridyl) - 1 piperazine and one aryloxpropanol derivative do not improve cataract. So the appearance of cataracts is probably due to substitution of an alkylaryl side chain on the N-4 position of (4' - pyridyl) - piperazine.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002386:Cataract / Q000139:chemically induced*; D007908:Lens, Crystalline / Q000187:drug effects; D008297:Male; D010879:Piperazines / Q000633:toxicity*; D051381:Rats; D012867:Skin / Q000187:drug effects; D013329:Structure-Activity Relationship
D010879:Piperazines