Impurities in drugs III: Trihexyphenidyl.
Two lots of trihexyphenidyl hydrochloride raw material, one lot of elixir, and 10 lots of tablets were examined for impurities by TLC. Impurities found were 1-phenyl-2-propenone, 3-piperidinopropiophenone, and 3-aminopropiophenone. Not all impurities were present in all lots, and none exceeded 1.9% of the label drug claim. Impurities were identified by mass spectrometry and by comparison of TLC Rf values and GLC retention times to those of synthesized specimens of the impurities.
D002855:Chromatography, Thin Layer; D004340:Drug Contamination; D013607:Tablets; D014282:Trihexyphenidyl / Q000032:analysis*
D013607:Tablets; D014282:Trihexyphenidyl