Uveal malignant melanoma in three generations of the same family.
Three patients in three successive generations from the same family had choroidal malignant melanoma. The third generation patient had multiple primary malignancies; his siblings also had multiple malignancies. Chromosome studies of the third generation patient revealed no abnormality. To the best of our knowledge, this is the second such pedigree reported.
D000328:Adult; D000368:Aged; D005134:Eye Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000235:genetics* / Q000473:pathology; D009378:Neoplasms, Multiple Primary / Q000235:genetics / Q000473:pathology; D010375:Pedigree; D014603:Uveal Diseases / Q000235:genetics* / Q000473:pathology