[Effect of diet and L-thyroxine on deiodination of L-thyroxine in rat liver].
Male Wistar rats on 3 or 50% fat diet for 14 weeks were treated during 6 weeks with L-thyroxine (5 or 25 or 50 microgram 100 g body weight/2 times weekly, sc.) and the activity of L-thyroxine-deiodinase was determined in supernatans of liver homogenates. With increasing thyroxine lading the deiodinating activity increases statistically significantly within each diet group. The liver of animals on 50% fat diet deiodinates increasing thyroxine doses to a lesser extent than livers of animals on 3% fat diet. It is discussed that high fat diet influences thyroid function and that thyroxine shares effectiveness and undergoes deiodination also in other tissues, probably in fat tissue, to a higher extent.
D000818:Animals; D004041:Dietary Fats; D007453:Iodide Peroxidase / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010544:Peroxidases / Q000378:metabolism*; D051381:Rats; D013974:Thyroxine / Q000378:metabolism* / Q000494:pharmacology
D004041:Dietary Fats; D010544:Peroxidases; D007453:Iodide Peroxidase; D013974:Thyroxine
Zum Einfluss von Diät und L-Thyroxin auf die Dejodierung von L-Thyroxin in der Leber von Ratten.