[Pharmacokinetic indices of penicillin and semicillin (ampicillin) in kidney diseases in children].
The kinetics of penicillin and semicillin was studied in 80 children at the age of 5 to 14 suffering from glomerulonephritis and pyelonephrities. The Bertolotti penicillin test revealed an isolated or associated (with lowered glomerular filtration and function of the osmotic concentration) decrease in the secretory function of the proxymal nephron in the patients without the signs of chronic renal insufficiency. The results of the study on the pharmacokinetics of simicillin indicated definite regularities in its excretion with urine as dependent on the period of its use and the state of the renal function. When semicillin was used in therapeutic doses, its concentration in urine exceeded the MIC with respect to all bacteria isolated from the urine specimens of the patients with pyelonephritis. Control of the antibiotic blood levels in children with kidney diseases at the stage of chronic renal insufficiency is necessary for choosing the optimal dose and intervals between the drug injections.
D000293:Adolescent; D000667:Ampicillin / Q000008:administration & dosage / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D006801:Humans; D007674:Kidney Diseases / Q000378:metabolism*; D007700:Kinetics; D010406:Penicillins / Q000008:administration & dosage / Q000378:metabolism*; D013997:Time Factors
D010406:Penicillins; D000667:Ampicillin
Nekotorye pokazateli farmakokinetiki penitsillina i semitsillina (ampitsillina) pri zabolevaniiakh pochek u deteĭ.