title: The connection of plasma triiodothyronine levels with the sex-dependent body weight loss after bilateral pallidal lesion in rats.
abstract: Previous data showed that after bilateral pallidal lesion (GPL) the weight loss of animals is higher in males than females. Data in the literature have called attention to the possible involvement of thyroid hormones. The sex dependence of weight loss was prevented by neonatal castration. In the present experiments, plasma triiodothyronine level was determined in neonatally castrated and non-castrated male and female rats on the 4th day after GPL. Body weight changes in food and water deprived male and female rats were compared after 4 days of T3 administration. A positive correlation between weight loss and T3 levels was found but there was no difference in mean T3 values between male and females. In the non-castrated group, T3 levels were higher in lesioned than in food and water deprived animals. In neonatally castrated animals no such difference was found. T3 administration caused a uniform weight loss in both sexes. It seems that while they play a role in the mechanism of weight loss after GPL, the sex-dependence is not due to changes in factors involved in regulation of the thyroid hormone level.
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000502:physiology; D001835:Body Weight; D002369:Castration; D005260:Female; D005508:Food Deprivation; D005917:Globus Pallidus / Q000502:physiology*; D008297:Male; D051381:Rats; D012737:Sex Factors; D013997:Time Factors; D014284:Triiodothyronine / Q000097:blood*; D014868:Water Deprivation
chemical_list: D014284:Triiodothyronine