[Use of visken and hyperstat in hypertensive crisis].
Visken (pindolol), a blocking agent of adrenergic beta-receptors, was used in the treatment of hypertensive crisis in 30 patients (stage I of the disease in 4, stage II in 23, stage III in 3). Intravenous injfection of visken in a dose of 1 mg led to a decrease of arterial pressure in all patients and relieved the clinical manifestations of crisis completely or partly. Significant reduction of arterial pressure and deceleration of pulse were already in evidence in 5 minutes after injection of the drug. In most patients maximum drop in pressure occurred in 30--60 minutes. There were no complications. As compared to obsidan (propranolol), which was used by other authors in hyperkinetic-type crisis, visken had the same effect on pressure and pulse. The peripheral vasodilator hyperstat (diazoxide) was used in the treatment of crisis in 28 patients with hypertensive disease (stage II of the disease in 21, and stage III in 7). In intravenous injection of 300 mg of hyperstat the hypotensive effect occurred in 1--5 minutes and reached maximum in 5 minutes. A hypotensive and clinical effect was noted in all patients. No complications were observed. On comparison with the results obtained by other authors in hyperstat treatment of hypo- and eukinetic types of crisis no essential difference in the hypotensive effect were noted.
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D003981:Diazoxide / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D010869:Pindolol / Q000008:administration & dosage / Q000627:therapeutic use*
D010869:Pindolol; D003981:Diazoxide
Primenenie viskena i giperstata pri gipertonicheskom krize.