[Effect of etimizol on the noradrenaline content and energy metabolism in the rat central nervous system and myocardium].
It was shown in experiments on rats that ethimizol (25 mg/kg) produces the decreasing of noradrenaline in the brain tissue 20 min after intraperitoneal injection. The noradrenaline content is restored in 3 hours. The changes in the balance of tissue noradrenaline were accompanied by phosphorylase activation, decline of the glycogen level and by increasing of glucose and creatine phosphate concentrations. Ethimizol in the same dose did not produce any influence on the tested metabolic parameters in the myocardium of normal rats.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002490:Central Nervous System / Q000187:drug effects* / Q000378:metabolism; D004734:Energy Metabolism / Q000187:drug effects*; D005042:Etimizol / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects*; D007093:Imidazoles / Q000494:pharmacology*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats
D007093:Imidazoles; D005042:Etimizol; D009638:Norepinephrine
Vliianie étimizola na soderzhanie noradrenalina i énergeticheskii obmen v tsentral'noi nervnoi sisteme i miokarde krys.