The effects of desmethylimipramine on the pharmacological actions of alpha methyldopa in man.
The effect of pretreatment with the tricyclic antidepressant desmethylimipramine (DMI) 75 mg daily for 3 days on the action of oral methyldopa 750 mg was investigated in a double blind crossover design in volunteers. DMI pretreatment caused a small but not significant increase in supine systolic and diastolic blood pressure and heart rate. However, the effects of methyldopa on lying and standing blood pressure and heart rate were not markedly altered by pretreatment. In particular, the fall in standing blood pressure after methyldopa was present with and without DMI and the sedative action of methyldopa was similar. DMI alone reduced saliva production. No evidence was found that tricyclic antidepressant drugs significantly modify the hypotensive effect of methyldopa in man.
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002395:Catecholamines / Q000378:metabolism; D003891:Desipramine / Q000378:metabolism / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006993:Hypnotics and Sedatives; D007700:Kinetics; D008297:Male; D008750:Methyldopa / Q000378:metabolism / Q000494:pharmacology*; D012472:Salivation / Q000187:drug effects; D013997:Time Factors
D002395:Catecholamines; D006993:Hypnotics and Sedatives; D008750:Methyldopa; D003891:Desipramine