Some properties of 5-hydroxytryptamine receptors in the hindquarters of the rat.
1 The rat hindquarter preparation, as described, responds with reproducible vasoconstriction to noradrenaline and tryptamines. 2 The receptors involved in these responses are distinct. 3 Evidence of heterogeneity of tryptamine receptors was not obtained. 4 The 5-hydroxytryptamine (5-HT) antagonists, methysergide and cyproheptadine, although very potent, displayed antagonism of a non-competitive type whereas a series of phenothiazines and phentolamine displayed competitive antagonism against 5-HT. 5 For the phenothiazines the order of increasing potency was promazine less than chlorpromazine less than triflupromazine.
D000818:Animals; D001667:Binding, Competitive; D001808:Blood Vessels / Q000187:drug effects*; D002746:Chlorpromazine / Q000494:pharmacology; D006614:Hindlimb / Q000098:blood supply; D066298:In Vitro Techniques; D051381:Rats; D011985:Receptors, Serotonin / Q000187:drug effects*; D012702:Serotonin Antagonists / Q000494:pharmacology; D014661:Vasoconstriction / Q000187:drug effects
D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D002746:Chlorpromazine