[Effect of hydrocortisone on the state of liver chromatin in rats of different age].
Hydrocortisone (5 mg/100 g) injected intraperitoneally induced redistribution of hepatic chromatin fractions in pubertal (aged 6--8 months) and old (aged 24--26 months) rats. Changes in the content of these chromatin fractions begin earlier and end later in old animals. Hydrocortisone stimulated 14C-orotic acid incorporation into RNA of active and inactive hepatic chromatin in rats of both age groups. The maximal incorporation of 14C-orotic acid into RNA of inactive chromatin in pubertal rats occurred 7 hours after the hormone administration, and in old rats after 4 hours; in case of active chromatin these figures were 17 and 6 hours, respectively.
D000375:Aging; D000818:Animals; D002250:Carbon Radioisotopes; D002843:Chromatin / Q000378:metabolism*; D005938:Glucocorticoids / Q000494:pharmacology; D006854:Hydrocortisone / Q000494:pharmacology*; D007553:Isotope Labeling; D008930:Mitochondria, Liver / Q000648:ultrastructure*; D009963:Orotic Acid / Q000378:metabolism; D012313:RNA / Q000096:biosynthesis; D051381:Rats
D002250:Carbon Radioisotopes; D002843:Chromatin; D005938:Glucocorticoids; D009963:Orotic Acid; D012313:RNA; D006854:Hydrocortisone
Vliianie gidrokortizona na sostoianie khromatina pecheni krys raznogo vozrasta.