title: [Synthesis of the fragments A1-,, A9-15 and A16-21 of ovine insulin A chain using the S-tert-butylmercapto residue for thiol protection (author's transl)].
abstract: The following paper describes the synthesis of the fragments A1-8, A9-15 and A16-21 of the ovine insulin A chain using the S-tert-butylmercapto residue for thiol protection. The synthesized fragments, which showed a good solubility in organic solvents, were partially deprotected with trifluoracetic acid and converted to the corresponding S-sulfonates quantitatively by oxidative sulfitolyses at pH 7.6.
mesh_terms: D000818:Animals; D007202:Indicators and Reagents; D007328:Insulin / Q000138:chemical synthesis*; D046911:Macromolecular Substances; D008722:Methods; D010446:Peptide Fragments / Q000138:chemical synthesis*; D012756:Sheep
chemical_list: D007202:Indicators and Reagents; D007328:Insulin; D046911:Macromolecular Substances; D010446:Peptide Fragments
vernacular_title: Synthese der Fragmente A1-8, A9-15 und A16-21 der Schafinsulin-A-Kette unter Verwendung des S-tert-Butylmercaptorestes als Thiolschutzgruppe.