title: [Effect of phenoxybenzamine on the renal and general circulation in the hypovolemic hypotonic dog].
abstract: For the estimation of the haemodynamic and metabolic effect of 1 mg/kg phenoxybenzamine in a kidney donor with craniocerebral trauma model experiments were performed on dogs with hypovolaemic hypotension. The results show that phenoxybenzamine leads to vasodilatation in a constant aortic pressure of 80 mm Hg in the systemic circulation as well as in the renal circulation with different speed of reaction. Thus the arterial and venous O2 and CO2 partial pressure normalizes and the diuresis increases. On the other hand, the hypotension-conditioned metabolic acidosis and the symptoms of an acute renal failure may not be influenced.
mesh_terms: D000136:Acid-Base Equilibrium / Q000187:drug effects; D000818:Animals; D001775:Blood Circulation / Q000187:drug effects*; D001810:Blood Volume; D004231:Diuresis / Q000187:drug effects; D004285:Dogs; D007022:Hypotension / Q000188:drug therapy; D007668:Kidney / Q000187:drug effects*; D010313:Partial Pressure; D010643:Phenoxybenzamine / Q000627:therapeutic use*; D010952:Plasma Substitutes; D014019:Tissue Donors
chemical_list: D010952:Plasma Substitutes; D010643:Phenoxybenzamine
vernacular_title: Untersuchungen über die renale und allgenmeine Kreislaufwirkung von Phenoxybenzamin am hypovolämischen, hypotonen Hund.