Antiparasitic agents. 3. Synthesis and anthelmintic activities of novel 2-pyridinyl-5-isothiocyanatobenzimidazoles.
The preparation and anthelmintic activities of a series of 2-pyridinyl-5-isothiocyanatobenzimidazoles are described. In the primary oral mouse screen, six derivatives showed 100% taeniacidal activity at 0.2% in diet. The most active member in this series, 1c, is potentially an effective gastrointestinal nematocide in sheep at 50 mg/kg po.
D000818:Animals; D000871:Anthelmintics / Q000138:chemical synthesis*; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D004285:Dogs; D006925:Hymenolepiasis / Q000188:drug therapy; D051379:Mice; D008989:Monieziasis / Q000188:drug therapy; D009349:Nematode Infections / Q000188:drug therapy; D010270:Parasite Egg Count; D012756:Sheep; D013329:Structure-Activity Relationship; D013622:Taeniasis / Q000188:drug therapy; D013861:Thiocyanates / Q000138:chemical synthesis* / Q000494:pharmacology
D000871:Anthelmintics; D001562:Benzimidazoles; D013861:Thiocyanates