DPH-induced macrocytosis in the 14-day rat foetus.
Phenytoin injected in the pregnant rat induces in the 14-day-old foetus macrocytosis of the primitive red blood cells which is sometimes linked with limb haemorrhages. The action of the drug is possibly the result of a blood circulation disturbance.
D000748:Anemia, Macrocytic / Q000139:chemically induced*; D000818:Animals; D005260:Female; D005333:Fetus / Q000502:physiology; D008431:Maternal-Fetal Exchange; D010672:Phenytoin / Q000494:pharmacology*; D011247:Pregnancy; D051381:Rats
D010672:Phenytoin