title: Influence of milk products on fluoride bioavailability in man.
abstract: The effect of milk products on the gastrointestinal absorption of fluoride from sodium fluoride tablets was studied in five healthy subjects. Two different diets were tested: (1) 250 ml standardized milk (3% fat) and (2) 500 ml of milk, 3 pieces of white bread with cheese and 150 ml of yoghurt. The 100% bioavailability of sodium fluoride tablets during fasting was greatly decreased by coadministration of milk products: with Diet 1 the absolute bioavailability calculated from combined plasma and urine data was in the range 50--79% and with Diet 2 it ranged from 50--71%. It is suggested that the decreased bioavailability produced by dairy products should be taken into account when establishing flouride dosage regimens for prophylaxis of caries.
mesh_terms: D000328:Adult; D001682:Biological Availability; D003611:Dairy Products; D005215:Fasting; D005459:Fluorides / Q000378:metabolism*; D005502:Food; D006801:Humans; D007700:Kinetics; D013997:Time Factors
chemical_list: D005459:Fluorides