title: Single point clearance estimation.
abstract: Linear relationships were observed between the log of total body clearance (C1B) and simulated serum concentrations (Cmin) six hours after a test dose of chloramphenicol, as well as between C1B and the reciprocal of Cmin. Correlation coefficients for these relationships were 0.988 and 0.977, respectively. Clearance estimates obtained from a single serum sample following a test dose of a drug may prove to be a useful method of predicting dosage requirements for individual patients.
mesh_terms: D002701:Chloramphenicol / Q000008:administration & dosage / Q000097:blood*; D006801:Humans; D007700:Kinetics; D008954:Models, Biological
chemical_list: D002701:Chloramphenicol