[Effect of some drugs on colchicine uptake by colchicine-sensitive and resistant cells].
The effect of several agents on 3H-colchicine, uptake by L cells and resistant to colcemide and colchicine L-53 cells was studied. Vinblastin to which L-53 cells are cross-resistant increases labeled colchicine uptake by L and L-53 cells 3- and 8-fold, respectively. The substances which decrease ATP level in the cells (olygomycin, etc.) enhance colchicine uptake by L and L-53 cells 2--4-fold. In the presence of these substances colchicine uptake by resistant cells is more intensive than by sensitive L cells. The structural analogue of colchicine, lumicolchicine, inactive in binding the microtubular protein tubulin enhances colchicine uptake by L and L-53 cells to about equal degree.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D003078:Colchicine / Q000378:metabolism* / Q000494:pharmacology; D003703:Demecolcine / Q000494:pharmacology; D004351:Drug Resistance; D007700:Kinetics; D007739:L Cells / Q000187:drug effects / Q000378:metabolism*; D008162:Lumicolchicines / Q000494:pharmacology; D051379:Mice; D009840:Oligomycins / Q000494:pharmacology; D014747:Vinblastine / Q000494:pharmacology
D008162:Lumicolchicines; D009840:Oligomycins; D014747:Vinblastine; D000255:Adenosine Triphosphate; D003078:Colchicine; D003703:Demecolcine
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