Effect of 2,6-cis-diphenylhexamethylcyclotetrasiloxane on the reproductive organs of male mice.
Mice treated with tetrasiloxane, 20 and 40 mg/kg/day, showed lesions in the reproductive organs, cytological changes in the pituitary glands, and changes in levels of cholesterol, phosphomonoesterases, transaminases, 5'-nucleotidase, lactic and isocitric dehydrogenases, and ATPase.
D000726:Androgen Antagonists / Q000633:toxicity; D000818:Animals; D004822:Epididymis / Q000187:drug effects / Q000648:ultrastructure; D008297:Male; D051379:Mice; D011467:Prostate / Q000187:drug effects / Q000648:ultrastructure; D012669:Seminal Vesicles / Q000187:drug effects / Q000648:ultrastructure; D012828:Silicones / Q000633:toxicity*; D012833:Siloxanes / Q000633:toxicity*; D013737:Testis / Q000187:drug effects* / Q000648:ultrastructure
D000726:Androgen Antagonists; D012828:Silicones; D012833:Siloxanes