The effect of ethanol ingestion on plasma biochemistry and the pancreas in the rat.
Intra-gastric ethanol given daily for 4 weeks caused transient elevations in plasma amylase and total protein with a fall in total calcium. Light microscopic examination of the pancreas at 4 weeks showed areas of acinar cell degranulation and necrosis without an inflammatory cell infiltrate. The pancreatic changes are unlikely to be an artefact, but rather a direct toxic effect of the alcohol as confirmed by the biochemical changes.
D000681:Amylases / Q000097:blood*; D000818:Animals; D001798:Blood Proteins / Q000032:analysis; D002118:Calcium / Q000097:blood*; D000431:Ethanol / Q000009:adverse effects*; D008297:Male; D009336:Necrosis; D010179:Pancreas / Q000187:drug effects / Q000473:pathology*; D051381:Rats; D012709:Serum Albumin / Q000032:analysis
D001798:Blood Proteins; D012709:Serum Albumin; D000431:Ethanol; D000681:Amylases; D002118:Calcium