title: Altered urinary excretion of human kininase activity in hypertension.
abstract: This study describes the levels of urinary kininase activity in hypertension. Urinary kininase activity in essential and secondary hypertensive patients was higher than in controls (1010.2 +/- 102.7 versus 114.4 +/- 23.1 ng destroyed bradykinin/min.; p less than 0.001). In a group of hypertensive diabetics without nephropathy kininase activity in urine was decreased (46.0 +/- 12.7 ng destroyed bradykinin/min.). This investigation shows that in hypertension urinary kininase activity reaches higher levels. An inverse correlation was found between urinary kallikrein and urinary kininase activity from essential hypertensive patients.
mesh_terms: D000293:Adolescent; D000328:Adult; D001920:Bradykinin; D002268:Carboxypeptidases / Q000652:urine*; D003925:Diabetic Angiopathies / Q000201:enzymology*; D006801:Humans; D006973:Hypertension / Q000201:enzymology*; D001121:Lysine Carboxypeptidase / Q000652:urine*; D008297:Male; D008875:Middle Aged; D012016:Reference Values
chemical_list: D002268:Carboxypeptidases; D001121:Lysine Carboxypeptidase; D001920:Bradykinin