Vaccinia virus infection of the central nervous system in X-irradiated mice.
The effect of X-irradiation on experimental vaccinia infection of BALB/c mice was studied. As compared with nonirradiated controls, the X-irradiated animals exhibited (i) a time lag in virus replication (delayed, but protracted replication); (ii) a delayed and repressed immune response: (iii) more severe acute cytocidal infection of leptomeninges, choroid plexus, ependyma, and vessels, with extensive damage to the brain-barrier system; and (iv) noncytocidal, latent infection of glial cells and neurons. Several animals developed acute or subacute demyelination disease, resembling experimental allergic encephalomyelitis or postinfectious encephalomyelitis.
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D002493:Central Nervous System Diseases / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D005260:Female; D007153:Immunologic Deficiency Syndromes / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D014615:Vaccinia / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D014616:Vaccinia virus / Q000254:growth & development; D014965:X-Rays
D000914:Antibodies, Viral