Serotonergic modulation of yawning.
Yawning induced by intraperitoneal (IP) injection of physostigmine (0.15 mgKg-1), in infant or adult rats is potentiated by Lu 10-171 (0.5-10 mgKg-1), a selective serotonin uptake inhibiting drug, which, by itself does not induce yawning. This effect is counteracted by metergoline (5-10 mgKg-1, IP) which blocks serotonin postsynaptic receptors. It is suggested that serotonin may exert a positivie modulating effect on yawning.
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D008711:Metergoline / Q000494:pharmacology; D010830:Physostigmine / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000502:physiology*
D008711:Metergoline; D012701:Serotonin; D010830:Physostigmine