Lymphocyte culture supernatants prevent sickling of red blood cells.
Metabisulphate-treated red blood cells from sickle-cell patients were protected from sickling by exposure to supernatants from cultures of phytohemagglutinin-stimulated normal human lymphocytes. Such supernatants, when not thus stimulated, afforded no protection.
D000234:Adenoids / Q000166:cytology; D000755:Anemia, Sickle Cell / Q000097:blood*; D000986:Antisickling Agents / Q000378:metabolism*; D002648:Child; D003470:Culture Media; D004912:Erythrocytes / Q000473:pathology*; D006801:Humans; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000378:metabolism*; D010835:Phytohemagglutinins
D000986:Antisickling Agents; D003470:Culture Media; D010835:Phytohemagglutinins