Arachidonic acid aggregates neutrophils.
Arachidonic acid, but not several structurally similar fatty acids, stimulated neutrophils in suspension to aggregate; this effect was blocked by 5, 8, 11, 14-eicosatetraynoic acid, an inhibitor of arachidonic acid metabolism. Analagous to platelets, arachidonate may be a precursor of active metabolites which mediate neutrophil responses.
D001095:Arachidonic Acids / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D002449:Cell Aggregation / Q000187:drug effects*; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D009113:Muramidase / Q000378:metabolism; D009504:Neutrophils / Q000166:cytology* / Q000201:enzymology; D013268:Stimulation, Chemical
D001095:Arachidonic Acids; D007770:L-Lactate Dehydrogenase; D009113:Muramidase