title: Phenytoin and carbamazepine in production of cleft palates in mice. Comparison of teratogenic effects.
abstract: The teratogenic activity of two anticonvulsant drugs, phenytoin sodium and carbamazepine, was studied in pregnant mice fed phenytoin and carbamazepine during days 8 to 13. Incidence of palatal defects and other abnormalities correlated with increasing dosages and blood levels of the drugs. Phenytoin produced a much higher incidence of teratogenic effects than carbamazepine.
mesh_terms: D000818:Animals; D002220:Carbamazepine / Q000009:adverse effects* / Q000097:blood; D002972:Cleft Palate / Q000139:chemically induced* / Q000196:embryology; D004305:Dose-Response Relationship, Drug; D005260:Female; D051379:Mice; D010672:Phenytoin / Q000009:adverse effects* / Q000097:blood; D011247:Pregnancy
chemical_list: D002220:Carbamazepine; D010672:Phenytoin