title: An improved method for the measurement of red cell survival using non-radioactive chromium.
abstract: An improved technique for the measurement of red cell survival is described in which non-radioactive 50Cr is used in patients for whom radioactive labels are not advisable. The 50Cr was measured by neutron activation analysis using a high resolution germanium (lithium) diode gamma-ray spectrometer. In adult controls, the values obtained were in the range accepted as normal for the 51Cr method, and double labelling experiments showed close agreement. The application of this technique to the measurement of red cell survival in pregnant women suspected of having haemolytic anemia is described.
mesh_terms: D000293:Adolescent; D000368:Aged; D000745:Anemia, Hemolytic, Congenital / Q000097:blood; D002648:Child; D002675:Child, Preschool; D002859:Chromium Isotopes; D004905:Erythrocyte Aging; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007504:Iron Radioisotopes; D008297:Male; D008722:Methods; D009501:Neutron Activation Analysis; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood; D013051:Spectrometry, Gamma; D013103:Spherocytosis, Hereditary / Q000097:blood
chemical_list: D002859:Chromium Isotopes; D007504:Iron Radioisotopes