A glucose-controlled insulin-delivery system: semisynthetic insulin bound to lectin.
A stable, biologically active glycosylated insulin derivative that is complementary to the major combining site of concanavalin A has been synthesized. Hormone release is proportional to the quantity of glucose present. Glucose regulation of exogenous insulin delivery could have important applications in the therapy of diabetes mellitus.
D001786:Blood Glucose / Q000378:metabolism; D003208:Concanavalin A / Q000378:metabolism; D007328:Insulin / Q000008:administration & dosage* / Q000031:analogs & derivatives / Q000378:metabolism; D008320:Maltose; D011952:Receptors, Concanavalin A / Q000378:metabolism
D001786:Blood Glucose; D007328:Insulin; D011952:Receptors, Concanavalin A; D003208:Concanavalin A; D008320:Maltose