The significance of leucocytosis in the X-irradiated tumour-bed.
(1) Present experiments confirm previous studies (Beck and Engel[1], 1927) according to which a tumour implanted s.c. into an X-irradiated area of mice is inhibited in its growth by 50 to 66% as compared with the implant of the nonirradiated side of the same animal. In the present series the growth inhibition amounted to practically 50%. (2) Exposure of the mouse skin to X-radiation caused a marked hyperleucocytosis within the first 24 hours, with a rapid decrease to normal levels within 4 or 5 days. (3) The inhibitory effect of X-radiation on the tumour growth and the inflammatory response of the skin (leucocyte count) did not run a parallel course except during the first few days after irradiation. The conclusion is drawn that hyperleucocytosis of the tumour bed is not the only cause for the tumour growth inhibition.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000473:pathology*; D005260:Female; D007958:Leukocyte Count; D007964:Leukocytosis / Q000473:pathology*; D051379:Mice; D009368:Neoplasm Transplantation; D012867:Skin / Q000528:radiation effects; D013997:Time Factors