Experimental chemotherapy of histoplasmosis in nude mice.
Nude (nu/nu) mice were infected with Histoplasma capsulatum and treated with varying doses of 3 drug regimens: oral ambruticin, intraperitoneal amphotericin B, and amphotericin B plus oral rifampin. Therapy with amphotericin B alone was the most effective regimen. High-dose ambruticin (50 mg/kg of body weight every 8 hours) led to significantly prolonged survival compared to that of untreated control animals, but no long-term cures. Addition of rifampin produced no benefit and might actually have decreased the efficacy of amphotericin B; this combination may be deleterious in a setting of immunodeficiency.
D000284:Administration, Oral; D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D006660:Histoplasmosis / Q000188:drug therapy*; D007274:Injections, Intraperitoneal; D051379:Mice; D008819:Mice, Nude; D011714:Pyrans / Q000008:administration & dosage / Q000627:therapeutic use
D000935:Antifungal Agents; D011714:Pyrans; D000666:Amphotericin B; C014964:ambruticin