Determination of terbutaline in post mortem human tissues by gas chromatography-mass spectrometry.
A method is described for the quantitative analysis of terbutaline in human tissues. Gas chromatography and chemical ionization mass fragmentography are used for selective and sensitive detection. A detection limit of 1.5 ng of the free drug per gram tissue is observed when 0.5 g of the dry tissue is used. No interference from the major metabolite, the sulphate conjugate of terbutaline, is found. Finally the method is applied to the post mortem tissues of two persons who used terbutaline frequently.
D001344:Autopsy; D002849:Chromatography, Gas; D006801:Humans; D013058:Mass Spectrometry; D013726:Terbutaline / Q000032:analysis*
D013726:Terbutaline