Lack of proportionality between rate of cell division and induction of tumors in carcinogen-exposed regenerating livers.
Although a single pulse of dimethylnitrosamine administered during the regenerative response of liver subsequent to 70% hepatectomy resulted in more primary hepatocellular carcinomas in treated livers than in controls, the response was not proportionate to the level of cell division. Further, the use of 55-g male Sprague-Dawley rats that displayed an extremely active regenerative response did not significantly shorten the lag period before the appearance of tumors. Of additional interest was the finding that the post-S period might be even more susceptible to dimethylnitrosamine than the S phase was. These results support the suggestion that many aspects of the interaction between carcinogens and dividing cells and the requirement for subsequent events for the development remain unclear.
D000818:Animals; D002453:Cell Cycle / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects*; D004247:DNA / Q000096:biosynthesis; D004128:Dimethylnitrosamine / Q000633:toxicity*; D008099:Liver / Q000187:drug effects; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced*; D008115:Liver Regeneration; D008297:Male; D051381:Rats
D004247:DNA; D004128:Dimethylnitrosamine