[Effect of prostaglandin F2-alpha on the course of pregnancy and 17-beta-estradiol concentration in blood plasma of mice].
The effect of prostaglandin F2 alpha (at a dose of 2 mg/kg, per each stage of development) on the mouse preimplantation development and 17 beta-estradiol concentration in the blood plasma was studied. Prostaglandin F2 alpha caused inhibition of mitoses in the embryo and decreased the percentage of embryos liberated from zona pellucida. Meanwhile blood plasma showed diminution of 17 beta-estradiol level as a result of administering prostaglandin F2 alpha. In physiological conditions a significant rise in 17 beta-estradiol level was recorded at the stage of blastocyst liberated from zona pellucida.
D000818:Animals; D020964:Embryo Loss / Q000139:chemically induced; D004622:Embryo, Mammalian / Q000187:drug effects*; D004958:Estradiol / Q000097:blood / Q000172:deficiency*; D004965:Estrogen Antagonists; D005260:Female; D005327:Fetal Resorption / Q000139:chemically induced; D051379:Mice; D011247:Pregnancy / Q000187:drug effects*; D011461:Prostaglandins F, Synthetic / Q000009:adverse effects*
D004965:Estrogen Antagonists; D011461:Prostaglandins F, Synthetic; D004958:Estradiol
Deĭstvie prostaglandina F2-alpha na techenie beremennosti i kontsentratsiiu 17-beta-estradiola v plazme krovi myshi.