[So-called antireceptor sera].
Experiments in delayed type hypersensitivity transfer were carried out with the aim of studying the ability of rabbit antisera against peritoneal exudate cells of rats sensitized with bovine gamma globulin or rabbit kidney tissue antigen to block peritoneal exudate cells of guinea pigs. In the serological test the antisera prepared against the cells of sensitized rats and tentatively named "receptor antisera", reacted not only with the cells of these rats, respectively, but also with guinea pig cells. In hypersensitivity transfer experiments in guinea pigs receptor antisera showed a blocking effect on the transferred cells, making them incapable of transferring hypersensitivity, i. e. rabbit antisera against rat peritoneal exudate cells reacted with guinea pig cells. This interaction was specific: the blocking effect was manifested only when guinea pigs whose cells were used in the transfer were sensitized with the same antigen as the rats against whose cells the receptor antisera had been prepared. The control antisera, taken for the treatment of the transferred cells in the same doses as the receptor antisera, had no blocking effect on the cells.
D000818:Animals; D004306:Dose-Response Relationship, Immunologic; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007106:Immune Sera / Q000276:immunology*; D007108:Immune Tolerance; D007114:Immunization; D007116:Immunization, Passive; D008214:Lymphocytes / Q000276:immunology; D011817:Rabbits; D051381:Rats; D011971:Receptors, Immunologic / Q000276:immunology*; D013997:Time Factors
D007106:Immune Sera; D011971:Receptors, Immunologic
Izuchenie tak nazyvaemykh antiretseptornykh syvorotok.