Three variations of hairlessness associated with albinism in the laboratory rat.
The relationship of three variants of hairlessness, or hypotrichosis, in laboratory rats were examined morphologically, genetically and histologically. The results indicated that the recessive gene causing the fuzzy characteristic in Wistar Furth rats and genes responsible for two other hypotrichotic coat variants in albino rats were the same gene or closely linked genes. The genes were in Linkage Group I of the Norway rat and were closely associated with the albino gene (c), with a recombination percentage of approximately 18%. The hypotrichotic animals had fewer and smaller hair follicles, smaller hair shafts, and a reduction of medullated hair shafts.
D000417:Albinism / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D000505:Alopecia / Q000662:veterinary*; D000818:Animals; D005260:Female; D005808:Genes, Recessive; D014644:Genetic Variation; D006197:Hair / Q000473:pathology; D006720:Homozygote; D007039:Hypotrichosis / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D008297:Male; D051381:Rats; D012376:Rodent Diseases / Q000235:genetics* / Q000473:pathology; D012867:Skin / Q000473:pathology