title: Tachyphylactic action of high doses of pentagastrin.
abstract: The study of the human LES was performed with manometrical methods for atropine action on gastrine tachyphylaxis. Our study points out that there is a complex self regulating neuronal circuit in the LES contraction. We discuss some hypothesis for the LES control. In particular ACh could activate an inhibitory adrenergic muscarinic receptor.
mesh_terms: D000328:Adult; D001285:Atropine / Q000494:pharmacology; D004943:Esophagogastric Junction / Q000187:drug effects*; D006801:Humans; D007275:Injections, Intravenous; D009119:Muscle Contraction / Q000187:drug effects; D010418:Pentagastrin / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D013618:Tachyphylaxis
chemical_list: D001285:Atropine; D010418:Pentagastrin