Wound healing. The effects of topical antimicrobial agents.
The effect of four commonly used topical antimicrobial agents on the rate of reepithelialization of clean wounds was evaluated in white domestic pigs. Neosporin Ointment was found to significantly increase the rate of reepithelialization by 25%, while Furacin significantly retarded the healing rate by 24%. Pharmadine, a preparation containing povidone-iodine, did not affect the rate of healing. Both Silvadene and its vehicle significantly increased the rate of reepithelialization by 28% and 21%, respectively. The effects of these agents cannot be explained on the basis of their antimicrobial activity.
D000818:Animals; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage*; D001414:Bacitracin; D004338:Drug Combinations; D007455:Iodine / Q000008:administration & dosage; D009355:Neomycin / Q000008:administration & dosage; D009583:Nitrofurazone / Q000008:administration & dosage; D009824:Ointments; D010577:Petrolatum / Q000008:administration & dosage; D011112:Polymyxin B / Q000008:administration & dosage; D011206:Povidone-Iodine / Q000008:administration & dosage; D012837:Silver Sulfadiazine / Q000008:administration & dosage; D013552:Swine; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects*
D000891:Anti-Infective Agents, Local; D004338:Drug Combinations; D009824:Ointments; D001414:Bacitracin; D010577:Petrolatum; C001816:bacitracin zinc, neomycin sulfate, polymyxin B, drug combination; D011206:Povidone-Iodine; D007455:Iodine; D009355:Neomycin; D011112:Polymyxin B; D012837:Silver Sulfadiazine; D009583:Nitrofurazone