Circulating immune complexes in acute schistosomiasis.
The sera of patients with acute and chronic schistosomasis were tested for the presence of circulating immune complexes with the 125I-Clq binding assay. Fourteen out of fifteen (93%) patients with acute schistosomiasis had elevated 125I-Clq binding activity, while only two out of eleven (18%) patients with chronic disease had C1q binding complexes. This difference was significant (P less than 0.001) and paralleled the degree of clinical didsease activity between the two groups of patients. IgG and IgM were readily detected in all of these circulating complexes but the specific parasite antigens initiating their formation could not be defined. The level of circulating immune complexes was inversely correlated with the absolute eosinophil counts for individuals in the acutely infected group, an observation compatible wiht the hypothesis that a functional role for the eosinophil is the destruction and elimination of immune complexes.
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000906:Antibodies / Q000032:analysis; D000936:Antigen-Antibody Complex; D002648:Child; D003172:Complement C1 / Q000276:immunology; D003176:Complement C3 / Q000032:analysis; D004804:Eosinophils; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007958:Leukocyte Count; D012552:Schistosomiasis / Q000097:blood / Q000276:immunology*
D000906:Antibodies; D000936:Antigen-Antibody Complex; D003172:Complement C1; D003176:Complement C3; D007074:Immunoglobulin G; D007075:Immunoglobulin M