title: Bacterial metabolism of propane-1,2-diol.
abstract: The pathway of propane-1,2-diol metabolism by a species of Flavobacterium able to grow on the diol as the sole source of carbon was influenced by the degree of aeration of the growth medium. Under strongly aerobic conditions the diol was exclusively catabolised to lactaldehyde by an initial diol oxidase, subsequently metabolised to pyruvate and then oxidised to CO2 by the tricarboxylic acid cycle. Under microaerophilic conditions some propane-1,2-diol was catabolised by the oxidase-initiated pathway, but some diol was alternatively catabolised by an inducible diol dehydrase to propionaldehyde and subsequently reduced to n-propanol as an end product of metabolism.
mesh_terms: D002455:Cell Division; D005417:Flavobacterium / Q000201:enzymology / Q000378:metabolism*; D005463:Fluoroacetates / Q000494:pharmacology; D010084:Oxidation-Reduction; D010101:Oxygen Consumption; D011190:Potassium Cyanide / Q000494:pharmacology; D011409:Propylene Glycols / Q000378:metabolism*; D013347:Subcellular Fractions / Q000378:metabolism
chemical_list: D005463:Fluoroacetates; D011409:Propylene Glycols; D011190:Potassium Cyanide