The effect of intravenous domperidone on the resting lower oesophageal sphincter pressure in dogs and baboons.
Domperidone (Motilium), a dopamine receptor blocking agent, increased the resting tone of the lower oesophageal sphincter in 15 dogs and 6 baboons. It is therefore a potentially useful drug in the management of gastrooesophageal reflux due to incompetence of the lower oesophageal sphincter.
D000818:Animals; D000932:Antiemetics / Q000494:pharmacology; D001562:Benzimidazoles / Q000494:pharmacology*; D004285:Dogs; D018492:Dopamine Antagonists; D004943:Esophagogastric Junction / Q000187:drug effects* / Q000502:physiology; D010215:Papio; D010880:Piperidines / Q000494:pharmacology*; D011312:Pressure
D000932:Antiemetics; D001562:Benzimidazoles; D018492:Dopamine Antagonists; D010880:Piperidines