title: A correlation between estrogen sulfotransferase levels and estrogen receptor status in human primary breast carcinoma.
abstract: Estrogen sulfotransferase (EC 2.8.2.4) activity and estrogen receptor levels were measured in 32 human primary breast cancer cytosol preparations. Two types of tumors were identified: type 1, in which estrogen sulfotransferase levels were low (less than 40 pmol 17 beta-estradiol 3-sulfate formed per mg protein per 2 hr) and were independent of [35S]adenosine 3'-phosphate 5'-phosphosulfate production from [35S]sulfate and adenosine triphosphate, and type 2, in which estrogen sulfotransferase levels ranged from 50 to 200 pmol 17 beta-estradiol 3-sulfate per mg protein per 2 hr and were correlated with [35S]adenosine 3'-phosphate 5'-phosphosulfate formation (r = 0.70; p less than 0.005). In type 1 tumors, 11 of 16 were estrogen receptor negative; in type 2 tumors, 2 of 16 were receptor negative. Estrogen sulfotransferase levels in receptor-negative tumors were significantly lower than the levels in receptor-positive tumors (p = 0.025).
mesh_terms: D001943:Breast Neoplasms / Q000378:metabolism*; D003600:Cytosol / Q000378:metabolism; D004967:Estrogens / Q000378:metabolism*; D004970:Estrone; D005260:Female; D006801:Humans; D009376:Neoplasms, Hormone-Dependent / Q000378:metabolism*; D010724:Phosphoadenosine Phosphosulfate / Q000096:biosynthesis; D011960:Receptors, Estrogen; D015238:Sulfotransferases; D013466:Sulfurtransferases / Q000378:metabolism*
chemical_list: D004967:Estrogens; D011960:Receptors, Estrogen; D004970:Estrone; D010724:Phosphoadenosine Phosphosulfate; D013466:Sulfurtransferases; D015238:Sulfotransferases; C020122:estrone sulfotransferase