Reversal of neuromuscular blockade by glycopyrrolate and neostigmine. A study of the effects on lower oesophageal sphincter tone.
The effect of intravenous glycopyrrolate and neostigmine, a drug combination routinely given to antagonize non-depolarising neuromuscular blockade, on lower oesophageal sphincter tone was studied in twenty patients undergoing Caesarean section. Glycopyrrolate 0.6 mg and neostigmine 2.5 mg i.v. increased LOS pressure insignificantly by a mean of 0.2 kPa (P less than 0.1). In contrast, glycopyrrolate 0.6 mg and neostigmine 5 mg increased LOS pressure by a mean of 1.2 kPa (P less than 0.001). The latter dosage of this drug combination thus appears preferable in patients presenting for emergency surgery, if the integrity of the lower oesophageal sphincter is to be maintained during extubation and recovery from general anaesthesia.
D000773:Anesthesia, Obstetrical; D002585:Cesarean Section; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004943:Esophagogastric Junction / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006024:Glycopyrrolate / Q000494:pharmacology*; D006801:Humans; D009388:Neostigmine / Q000494:pharmacology*; D009469:Neuromuscular Junction / Q000187:drug effects*; D011247:Pregnancy; D011312:Pressure; D011759:Pyrrolidines / Q000494:pharmacology*; D011897:Random Allocation
D004338:Drug Combinations; D011759:Pyrrolidines; D009388:Neostigmine; D006024:Glycopyrrolate