Conditioning of the H reflex by stimulation of the posterior tibial nerve in Parkinson's disease.
The excitability curve of the H reflex conditioned by stimulation of a mixed nerve was studied in eight Parkinsonism patients, before and after L-dopa therapy. There was no significant variation between the two curves. However, there was a reduction of the normal early inhibition of the H reflex conditioned by exteroceptive stimulation. This indicates the presence of alterations in the organisation of the reflex pathways at a spinal level in this disease.
D000368:Aged; D002230:Carbidopa / Q000627:therapeutic use; D003213:Conditioning, Psychological / Q000502:physiology*; D004359:Drug Therapy, Combination; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D006181:H-Reflex / Q000187:drug effects; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons / Q000187:drug effects / Q000502:physiology; D010300:Parkinson Disease / Q000188:drug therapy / Q000503:physiopathology*; D012023:Reflex, Monosynaptic / Q000187:drug effects; D013979:Tibial Nerve / Q000187:drug effects / Q000503:physiopathology*
D007980:Levodopa; D002230:Carbidopa