[Effect of hypobaric hypoxia on the acetate-1-14C incorporation rate in hydrophilic and hydrophobic brain phospholipid components].
Rats were kept in barochamber for 2 hours at the pressure of 240 mm Hg after subcutaneous administration of (1)14C-acetate. Hypobaric hypoxia caused depression in the incorporation of labeled acetate similar in both phospholipid (PL) components. But the dependence of depression in the metabolic rate upon hypothermia which accompanied hypoxia was more pronounced for hydrophobic portion of PB (carbon skeleton of fatty acids) than for hydrophilic one. Similarity in the degree of the hypoxia induced depression of incorporation of the precursors containing labeled phosphorus and carbon allows one to suggest that the carbon-containing parts of PL hydrophilic components (glycerol and nitrogen bases) and residues of ortho-phosphoric acid respond to hypoxia as a whole.
D000085:Acetates / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002250:Carbon Radioisotopes; D010100:Oxygen / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism*; D011312:Pressure; D051381:Rats; D013997:Time Factors
D000085:Acetates; D002250:Carbon Radioisotopes; D010743:Phospholipids; D010100:Oxygen
Vliianie gipobaricheskoĭ gipoksii na skorost' vkliucheniia atsetata-1-14C v gidrofil'nye i gidrofobnye komponenty fosfolipiov mozga.