[Prostaglandin E1. Emergency therapy in infants with preductal coarctation of the aorta (author's transl)].
Three infants with preductal coartation, tubular hypoplasia of the aortic arch, and VSD were treated with Prostaglandin E1 (PGE1)-infusion to dilate the ductus arteriosus Botalli. Before PGE1-therapy the infants were treated with Furosemide and Digitalis, but they remained oliguric or anuric. During PGE1-infusion the pressure in the descending aorta rose and urine output increased significantly. Obviously the blood flow into the descending aorta via the ductus arteriosus was improved during PGE1-infusion. In all three cases surgery was successfull after PGE1-therapy. Before PGE1-therapy of preductal coarctation the diagnosis should be clear and also classical therapy with Furosemide and Digitalis should be tried.
D001017:Aortic Coarctation / Q000188:drug therapy*; D001794:Blood Pressure; D004562:Electrocardiography; D004630:Emergencies; D005260:Female; D005263:Femoral Artery; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011458:Prostaglandins E / Q000627:therapeutic use*; D011674:Pulse
D011458:Prostaglandins E
Prostaglandin E1. Notfalltherapie bei präductaler Aortenisthmusstenose des Neugeborenen.