Herbicidins F and G, two new nucleoside antibiotics.
A mutant of Streptomyces saganonensis No. 4075, obtained with N-methyl-N'-nitro-N-nitrosoguanidine treatment, produced herbicidins F and G without herbicidins A and B. Isolation of the antibiotics was performed by adsorption on resinous adsorbent followed by elution with aqueous MeOH. Herbicidin F was obtained as colorless needles after extraction of the eluate using methylene dichloride. Purification of herbicidin G was completed with silica-gel chromatography to give a crystalline powder. physico-chemical characterization revealed that herbicidins F and G were new nucleoside antibiotics having an adenine moiety in their structures. There was no inhibition activity at 100 micrograms/ml of herbicidins F and G against all of bacteria and yeast tested. Herbicidin F, as well as herbicidin G, are inhibitory activity against some of fungi such as Tricophyton rubrum (MIC; 6.25 micrograms/ml), T. asteroides (6.25 micrograms/ml), T. mentagrophytes (6.25 approximately 12.5 micrograms/ml), Botrytis cinerea (12.5 micrograms/ml), Blastomyces brasiliensis (12.5 approximately 25 micrograms/ml).
D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis* / Q000096:biosynthesis / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D005285:Fermentation; D006540:Herbicides / Q000032:analysis* / Q000378:metabolism; D051379:Mice; D011684:Purine Nucleosides / Q000032:analysis / Q000378:metabolism; D013302:Streptomyces / Q000235:genetics / Q000378:metabolism
D000900:Anti-Bacterial Agents; D006540:Herbicides; D011684:Purine Nucleosides