Lipid metabolism, atherogenesis, and haemostasis in Eskimos: the role of the prostaglandin-3 family.
In Eskimos coronary heart disease is a rarity. This can partly be explained by their favorable plasma lipid levels. An additional factor seems, however, to be that in Eskimo food polyunsaturated fatty acids of the omega-3 series replace those of the omega-6 series. C20:5, omega-3 can be converted by the vessel wall to an antiaggregatory substance, whereas it has no proaggregatory effect on platelets. Consistent with these findings Eskimos were found to have a nearly 2-fold longer bleeding time than Danes. Platelet aggregability, too, was markedly depressed when exposing platelets from Eskimos to ADP and collagen.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000367:Age Factors; D001780:Blood Coagulation Tests; D001792:Blood Platelets / Q000502:physiology*; D002784:Cholesterol / Q000097:blood; D003094:Collagen / Q000494:pharmacology; D003327:Coronary Disease / Q000453:epidemiology; D003718:Denmark; D004041:Dietary Fats / Q000494:pharmacology*; D006801:Humans; D004930:Inuit; D010974:Platelet Aggregation / Q000187:drug effects; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood; D044465:White People; D014914:Whole Blood Coagulation Time
D004041:Dietary Fats; D014280:Triglycerides; D000244:Adenosine Diphosphate; D003094:Collagen; D002784:Cholesterol