The effect of lead on aminopyrine N-demethylation.
The effect of various lead salts on "in vitro" aminopyrine N-demethylation was investigated. Lead was administered to male rats as a 1% solution in the drinking water. After seven days of lead treatment it was found that lead chloride and lead acetate had no effect on microsomal aminopyrine N-demethylation while lead nitrate increased aminopyrine metabolism. Intraperitoneal administration of either lead chloride or lead nitrate at a dose of 20 mg./kg. decreased metabolism. Lead chloride by oral administration did not suppress phenobarbital induction of aminopyrine metabolism in rats.
D000085:Acetates / Q000494:pharmacology; D000284:Administration, Oral; D000633:Aminopyrine N-Demethylase / Q000378:metabolism*; D000818:Animals; D002712:Chlorides / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D007854:Lead / Q000008:administration & dosage / Q000494:pharmacology*; D008099:Liver / Q000201:enzymology; D008297:Male; D009566:Nitrates / Q000494:pharmacology; D010634:Phenobarbital / Q000494:pharmacology; D000623:Porphobilinogen Synthase / Q000378:metabolism; D051381:Rats
D000085:Acetates; D002712:Chlorides; D009566:Nitrates; D007854:Lead; D000633:Aminopyrine N-Demethylase; D000623:Porphobilinogen Synthase; D010634:Phenobarbital