title: A pharmacokinetic study of bacampicillin in patients with chronic maxillary sinusitis.
abstract: The penetration of ampicillin into sinus mucosa and secretion after oral bacampicillin was studied in 30 patients subjected to radical maxillary sinus surgery. Bacampicillin in a dose of 1200 mg was administered orally before the operation and the concentrations in serum, sinus mucosa and secretion were assayed. The mean serum concentration (+/- SEM) reached its maximum of 13.4 +/- 1.2 micrograms/ml in about one hour. The mean concentrations in the secretion and mucosa after two to five hours were 1.6 +/- 0.5 micrograms/ml and 1.6 +/- 0.4 micrograms/ml respectively. The clinical course of the patients was mostly uneventful. Adverse effects probably caused by the drug were found in two cases.
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000667:Ampicillin / Q000031:analogs & derivatives / Q000032:analysis* / Q000097:blood; D001826:Body Fluids / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D008443:Maxillary Sinus / Q000032:analysis*; D008875:Middle Aged; D009092:Mucous Membrane / Q000032:analysis / Q000378:metabolism; D010406:Penicillins / Q000627:therapeutic use; D012852:Sinusitis / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D010406:Penicillins; D000667:Ampicillin