[Changes in the serum level of prekallikrein and kallikrein inhibitor activity in ischemic heart disease].
The authors studied the changes in four indices of kalikrein-kinine system. For that purpose 80 patients were examined, subdivided into the following groups; 1) hypertonic disease -- I -- II and II stage -- 20 patients; 2) myocardiosclerosis -- 20 patients; 3) unstable stenocardia -- 20 patients; 4) myocardial infarction -- 20 patients. The results obtained are compared with the results of the control group of 20 healthy subjects. The method of Colman and collaborators, modified by Veremeenko and collaborators was used for the quantitative determination of prekalikrein and kalikrein inhibitors. The data obtained suggest an enhanced kalikrein activity, very likely kinine as well, i.e. -- stimulation of kalikrein kinine system in IHD patients, determined by the increased formation and decreased inactivation of the enzyme (kalikrein).
D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000201:enzymology; D003327:Coronary Disease / Q000201:enzymology*; D004789:Enzyme Activation; D006801:Humans; D006973:Hypertension / Q000201:enzymology; D007610:Kallikreins / Q000032:analysis* / Q000037:antagonists & inhibitors*; D008875:Middle Aged; D009203:Myocardial Infarction / Q000201:enzymology; D011288:Prekallikrein / Q000032:analysis*
D011288:Prekallikrein; D007610:Kallikreins
Promeni v serumnoto nivo na prekalikreina i aktivnostta na inkhibitorite na kalikreina pri bolni s iskhemichna bolest na surtseto.