Hypertensive crisis possibly due to drug interaction.
This report describes a case of possible drug interaction in a patient taking chlorpromazine and guanethidine who experienced a hypertensive crisis following initiation of doxepin therapy. (We have been unable to find a report of a similar interaction at the doses described.) It is advised that physicians exercise caution when contemplating concomitant use of doxepin and guanethidine, even in usually recommended doses.
D001794:Blood Pressure / Q000187:drug effects; D002746:Chlorpromazine / Q000627:therapeutic use; D003863:Depression / Q000188:drug therapy; D004316:Doxepin / Q000009:adverse effects*; D004347:Drug Interactions; D006145:Guanethidine / Q000009:adverse effects*; D006801:Humans; D006973:Hypertension / Q000139:chemically induced* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged
D004316:Doxepin; D002746:Chlorpromazine; D006145:Guanethidine