Cardiopulmonary, hemocytologic and biochemical effects of xylazine in goats.
Intramuscular administration of xylazine at the rate of 0.22 mg/kg body weight caused a significant reduction in respiratory rates. Mean arterial blood pressure and rectal temperature were not altered. Preadministration of atropine did not affect the depth and pattern of respiration; however, the heart rate increased. A significant reduction in pH and arterial oxygen tension and an increase in carbon dioxide tension was observed after xylazine and xylazine following atropine treatment. Hemocytologic changes included a decrease in total erythrocytes, leukocytes, hematocrit and hemoglobin concentration and a rise in neutrophils with relative decrease in lymphocytes. Biochemical changes included a slight rise in potassium and a decrease in sodium concentration. Glucose level was significantly increased at maximum depth of sedation. The changes in hemocytologic and biochemical parameters returned to near preadministration level in 24-72 hours. No alteration was observed in the electrocardiogram. Xylazine was well tolerated, and the sedation was rapid in onset and lasted for about 30 minutes. The recovery was uneventful.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006041:Goats / Q000097:blood / Q000502:physiology*; D006339:Heart Rate / Q000187:drug effects*; D007958:Leukocyte Count; D008297:Male; D010100:Oxygen / Q000097:blood; D012119:Respiration / Q000187:drug effects*; D013843:Thiazines / Q000494:pharmacology*; D014991:Xylazine / Q000494:pharmacology*
D013843:Thiazines; D014991:Xylazine; D010100:Oxygen