Effect of methadone and morphine on serotonin uptake in rat periaqueductal gray slices.
In vitro effects of d,l-methadone and morphine on [3H]serotonin (3H-5-HT) uptake in rat periaqueductal gray (PAG) slices were investigated. Only methadone had a significant inhibitory effect on 3H-5-HT uptake which was significantly enhanced by naloxone. The systemic administration of methadone did not affect 3H-5-HT uptake in vitro. These data further weaken the possible relationship between narcotic analgesia and blockade of the 5-HT reuptake mechanism.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002535:Cerebral Aqueduct; D066298:In Vitro Techniques; D008297:Male; D008691:Methadone / Q000494:pharmacology*; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000378:metabolism*
D012701:Serotonin; D009270:Naloxone; D009020:Morphine; D008691:Methadone