The possibilities of reproducing effects of benzo[a]pyrene in a transformation test using Syrian hamster fetal lung cells.
Various dose levels of benzo[a]pyrene (BP) were tested on short-term cultured foetal hamster lung cells for transforming effects in vitro in 6 similar experiments. The statistical evaluation of the results indicated a weak reproducibility (P = 0.09). Factors which inherently influence such reproducibility were considered.
D000818:Animals; D001580:Benzopyrenes; D002471:Cell Transformation, Neoplastic / Q000139:chemically induced*; D002478:Cells, Cultured; D002999:Clone Cells; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D005260:Female; D066298:In Vitro Techniques; D008168:Lung; D008647:Mesocricetus; D011247:Pregnancy
D001580:Benzopyrenes