Double bond isomers of cloprostenol.
The syntheses of five compounds isomeric with the potent luteolytic agent cloprostenol are described. These are the trans-delta 5, cis and trans-delta 4, cis-delta 6 (methyl ester) and cis-delta 13 analogues. The cis-delta 4 isomer is as potent as cloprostenol as a luteolytic agent in hamsters but the others are markedly less so.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D003008:Cloprostenol / Q000138:chemical synthesis* / Q000494:pharmacology; D005260:Female; D006168:Guinea Pigs; D007536:Isomerism; D011461:Prostaglandins F, Synthetic / Q000138:chemical synthesis*; D014590:Uterine Contraction / Q000187:drug effects
D011461:Prostaglandins F, Synthetic; D003008:Cloprostenol