Glomerulonephritis associated with polymyositis.
Five patients with primary idiopathic polymyositis developed proteinuria associated with urine sediment abnormalities. Renal biopsies disclosed a focal mesangial proliferative glomerulonephritis with deposits of immunoglobulin and complement. After treatment of the polymyositis with corticosteroids, proteinuria and urine sediment changes disappeared within 4 to 8 wk along with an improvement in the muscle disease. Although the pathogenesis remains to be determined, immune complexes may be implicated in the etiology of this renal lesion.
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000936:Antigen-Antibody Complex; D001706:Biopsy; D005260:Female; D005921:Glomerulonephritis / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000473:pathology; D008297:Male; D009220:Myositis / Q000150:complications* / Q000188:drug therapy; D011507:Proteinuria / Q000209:etiology
D000305:Adrenal Cortex Hormones; D000936:Antigen-Antibody Complex