Stereospecificity at carbon 6 of fomyltetrahydrofolate as a competitive inhibitor of transport and cytotoxicity of methotrexate in vitro.
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D005575:Formyltetrahydrofolates / Q000494:pharmacology*; D007700:Kinetics; D007939:Leukemia L1210 / Q000378:metabolism; D008727:Methotrexate / Q000037:antagonists & inhibitors* / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains; D008968:Molecular Conformation; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013763:Tetrahydrofolates / Q000494:pharmacology*; D013997:Time Factors
D005575:Formyltetrahydrofolates; D013763:Tetrahydrofolates; D008727:Methotrexate