[Prevention of testosterone-vasopressin induced necrosis of the kidney cortex by cyproterone acetate].
After a ten days pretreatment with testosteron-propyonate administration of vasopressin induces bilateral cortical necrosis of kidneys in rats. When testosteron and cyproteron-acetate an androgen-blocking agent were given simultaneously vasopressin did not induce necrosis of the renal cortices. These findings suggest that androgen receptors of the kidney may take a part in eliciting this phenomenon.
D000818:Animals; D003534:Cyproterone / Q000627:therapeutic use*; D007672:Kidney Cortex / Q000187:drug effects / Q000648:ultrastructure; D007673:Kidney Cortex Necrosis / Q000139:chemically induced* / Q000517:prevention & control; D007678:Kidney Glomerulus / Q000187:drug effects / Q000648:ultrastructure; D051381:Rats; D013739:Testosterone / Q000009:adverse effects / Q000037:antagonists & inhibitors; D014667:Vasopressins / Q000009:adverse effects / Q000037:antagonists & inhibitors
D014667:Vasopressins; D013739:Testosterone; D003534:Cyproterone
Tesztoszteron+vazopresszin adagolást követo vesekéreg-nekrózis kivédése cyproteron acetáttal.