[Change in the activity of DNAse I inhibitor in the mouse spleen on the administration of a synthetic polyanion].
Synthetic polyanion pyran (copolimer of divinyl ether and maleic anhydride) injected to mice increases the titre of antibody to sheep red blood cells as well as the activity of serum DNAase I and DNAase I splenic inhibitor. Simultaneously a growth of the spleen weight takes place. A possible role of the DNAase I inhibitor system in the mechanism of the adjuvant action of synthetic polyanion is discussed.
D000199:Actins / Q000378:metabolism*; D000276:Adjuvants, Immunologic; D000818:Animals; D000837:Anion Exchange Resins; D000906:Antibodies / Q000032:analysis; D002417:Cattle; D003851:Deoxyribonucleases / Q000037:antagonists & inhibitors*; D004789:Enzyme Activation / Q000187:drug effects; D004912:Erythrocytes / Q000276:immunology; D007114:Immunization; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D011108:Polymers / Q000494:pharmacology; D011714:Pyrans / Q000494:pharmacology; D012756:Sheep / Q000276:immunology; D013154:Spleen / Q000187:drug effects* / Q000378:metabolism; D013997:Time Factors
D000199:Actins; D000276:Adjuvants, Immunologic; D000837:Anion Exchange Resins; D000906:Antibodies; D011108:Polymers; D011714:Pyrans; D003851:Deoxyribonucleases
Izmenenie aktivnosti ingibitora DNK-azy I v selezenke mysheĭ pri vvedenii sinteticheskogo polianiona.