An analgesic comparison study of indoprofen versus aspirin and placebo in surgical pain.
Single oral doses of 100 and 200 mg indoprofen were compared with 600 mg aspirin and placebo in a double-blind, completely randomized study of hospitalized patients with postoperative, post-fracture, or musculoskeletal pain. The patients evaluated their pain for 5 hours after administration of the study drug. Each of the three active treatments performed significantly better than placebo. The 200-mg dose level of indoprofen demonstrated the greatest analgesic activity based on pain intensity and pain relief scores and on the patients' global evaluations. The analgesic activity of 100 mg indoprofen fell between that of 200 mg indoprofen and 600 mg aspirin and was not significantly different from either.
D000328:Adult; D001241:Aspirin / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007216:Indoprofen / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D010149:Postoperative Pain / Q000188:drug therapy*; D010666:Phenylpropionates / Q000627:therapeutic use*; D010919:Placebos; D013997:Time Factors
D010666:Phenylpropionates; D010919:Placebos; D007216:Indoprofen; D001241:Aspirin