[The vasopressor role of ADH in the maintenance of blood pressure in experimentally hypertensive rats (author's transl)].
In order to investigate the vasopressor role of ADH in the regulation of blood pressure, passive immunization experiments with an antibody to AVP were carried out in experimentally hypertensive rats. In hypertensive rats treated with deoxycorticosterone acetate (DOCA), spontaneously hypertensive rats (SHR) and spontaneously hypertensive stroke-prone rats (SHR-sp), the intravenous injection of a specific vasopressin antibody resulted in a transient fall of blood pressure of 11 approximately 25mmHg, while in rats with two-kidney Goldblatt hypertension and normal rats, the blood pressure was not affected. This strongly suggests that ADH contributed to systemic vaso-constriction in DOCA hypertension and spontaneous hypertension in rats.
D000818:Animals; D001794:Blood Pressure; D002561:Cerebrovascular Disorders / Q000503:physiopathology; D003900:Desoxycorticosterone; D006973:Hypertension / Q000139:chemically induced / Q000378:metabolism / Q000503:physiopathology*; D007031:Hypothalamus / Q000032:analysis; D007106:Immune Sera; D008297:Male; D010902:Pituitary Gland / Q000032:analysis; D051381:Rats; D014667:Vasopressins / Q000032:analysis / Q000276:immunology / Q000502:physiology*
D007106:Immune Sera; D014667:Vasopressins; D003900:Desoxycorticosterone