Antileukemic activity of derivatives of 1,2-dimethyl-3,4-bis(hydroxymethyl)-5-phenylpyrrole bis(N-methylcarbamate).
A series of phenyl-substituted derivatives of 1,2-dimethyl-3,4-bis(hydroxymethyl)-5-phenylpyrrole bis(N-methylcarbamate) (1) were synthesized and tested for antileukemic activity against P388 lymphocytic leukemia in the mouse. All of the compounds tested, 1a--r, showed significant activity in this assay. Selected derivatives of 1 were tested against several bacteria and were found to have little or no antibacterial activity in the systems examined.
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D001419:Bacteria / Q000187:drug effects; D002219:Carbamates / Q000138:chemical synthesis / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology
D000970:Antineoplastic Agents; D002219:Carbamates; D011758:Pyrroles