Plasma and central nervous system kinetics of gamma-hydroxybutyrate.
Sodium gamma-hydroxybutyrate was administered to dogs in dosages of 200 to 1000 mg per kg with continuous EEG and temperature monitoring. Based on these studies, pulsed doses of 500 mg/kg of GHB were given and timed serum, cerebrospinal fluid (CSF) and brain samples obtained. In addition a group of animals were sacrificed 60 minutes after GHB administration and the regional distribution of GHB determined. The CSF kinetics of GBH suggests a passive diffusionof GHB into CSF but brain concentration peaked very early. Highest concentrations of GHB were found in cortical white matter with lower concentrations in subcortical areas.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D004285:Dogs; D004569:Electroencephalography; D006885:Hydroxybutyrates / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D007700:Kinetics; D013696:Temperature
D006885:Hydroxybutyrates