Possible relationship between salivary kallikrein and water-Na-K secretion stimulated by tityustoxin (TsTx).
Intravenous injection of purified scorpion toxin (TsTx) brings about the appearance of salivary flow with high levels of Na and K and kallikrein in the saliva of the rats. In experiments performed in vivo a positive correlation between Na and partially with K and kallikrein was observed in parotid and submaxillary saliva. After ouabaine, saliva K was increasing, whereas Na decreased, and a parallel decrease of kallikrein was observed. Adrenergic and cholinergic blocking drugs also showed a marked reduction in the output of Na (atropine), and partially of K (atropine or phentolamine), with a correlation in theoutput of kallikrein per min. The results of the present investigations support the hypothesis that salivary kallikrein-kinin system is probably involved in salivary control of Na, partially K and water secretion.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001834:Body Water / Q000378:metabolism*; D005260:Female; D007610:Kallikreins / Q000378:metabolism*; D010042:Ouabain / Q000494:pharmacology; D010306:Parotid Gland / Q000187:drug effects / Q000201:enzymology; D010646:Phentolamine / Q000494:pharmacology; D011188:Potassium / Q000378:metabolism*; D051381:Rats; D012463:Saliva / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D012604:Scorpion Venoms / Q000494:pharmacology*; D012964:Sodium / Q000378:metabolism*; D013363:Submandibular Gland / Q000187:drug effects / Q000201:enzymology
D012604:Scorpion Venoms; D010042:Ouabain; D001285:Atropine; D012964:Sodium; D007610:Kallikreins; D011188:Potassium; D010646:Phentolamine