Sister chromatid exchanges induced in cultured mammalian cells by chromate.
Chromate compounds induced sister chromatoid exchanges (SCEs) and chromosome aberrations in cultured mammalian cells. Similar increases in SCE frequency were observed in human fibroblasts exposed to the compounds K2Cr2O7 and K2CrO4. Marked increases in SCE frequency in cells exposed to chromate for a 48-h period were detected at concentrations between 10(-7) and 10(-6) M. Chromosome aberrations (primarily chromatid breaks) were also produced in human cells exposed to K2CrO4 at concentrations between 8 . 10(-7) and 3 . 10(-6) M. K2CrO4, but not the trivalent compound CrCl3, induced SCEs in Chinese hamster ovary (CHO) cells at low concentrations.
D000328:Adult; D002478:Cells, Cultured / Q000187:drug effects*; D002840:Chromates / Q000633:toxicity*; D002842:Chromatids / Q000187:drug effects*; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008769:Methylnitronitrosoguanidine / Q000633:toxicity; D012867:Skin / Q000166:cytology; D013997:Time Factors
D002840:Chromates; D008769:Methylnitronitrosoguanidine