The effect of insulin on the growth of transplanted tumors in mice.
The growth of four murine transplantable tumours, Ehrlich ascites or solid tumour, an aplastic carcinoma, B-16 melanoma, and a thymoma, were suppressed in mice treated daily with insulin (2 IU). Since insulin increased the number of plaque-forming cells and the phagocytic activity of the liver and spleen cells, the retardation of the tumour growth was ascribed to immunological mechanisms.
D000818:Animals; D000970:Antineoplastic Agents; D002277:Carcinoma / Q000188:drug therapy; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D005260:Female; D007328:Insulin / Q000494:pharmacology* / Q000627:therapeutic use; D008099:Liver / Q000187:drug effects; D008545:Melanoma / Q000188:drug therapy; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000188:drug therapy; D010587:Phagocytosis / Q000187:drug effects; D013154:Spleen / Q000187:drug effects; D013945:Thymoma / Q000188:drug therapy; D013953:Thymus Neoplasms / Q000188:drug therapy
D000970:Antineoplastic Agents; D007328:Insulin