[Effect of taurine on 45Ca2+ binding by the microsomal membranes of brain cells].
Effect of taurine o binding of 45Ca2+ and 8-aniline-I-naphthaline culfonate by microsomes of rat brain cells was studied. Increased accumulation of Ca2+ in phospholipids of microsomes as well as a distinct decrease in the number of sites for binding of 8-aniline-I-naphthaline sulfonate were observed in presence of taurine. Activity of Ca2+-ATPase was simultaneously increased. The data obtained suggest that the effect of taurine on biomembranes is related to local alterations in their surface charge.
D000817:Anilino Naphthalenesulfonates / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D002132:Calcium Radioisotopes; D002413:Cations, Divalent; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism; D008861:Microsomes / Q000187:drug effects / Q000378:metabolism*; D011485:Protein Binding / Q000187:drug effects; D051381:Rats; D013654:Taurine / Q000494:pharmacology*
D000817:Anilino Naphthalenesulfonates; D002132:Calcium Radioisotopes; D002413:Cations, Divalent; D013654:Taurine; D002118:Calcium
Vliianie taurina na sviazyvanie 45Ca2+ mikrosomal'nymi membranami kletok golovnogo mozga.