title: Inhibition of hypertonic-saline stimulated neurosecretory changes in the freshwater bivalve Indonaia caeruleus (Prashad) by chlorpromazine and reserpine.
abstract: In the present paper, the effects of reserpine (RSP) and chlorpromazine (CPZ) on the neurosecretory cells of a saline treated freshwater bivalve, Indonaia caeruleus have been tracked. After saline (0.1 ml of 1.5% NaCl per animal) treatment A and B cells of cerebral and visceral ganglia showed significant increase in cell area, nuclear diameter and decrease in the NSM, while administration of RSP (0.50 mg per animal) and CPZ (0.25 mg per animal), following the saline injection completely inhibited these changes. Physiological implications of these changes are discussed in the light of neurosecretory dynamics.
mesh_terms: D000818:Animals; D002746:Chlorpromazine / Q000494:pharmacology*; D005724:Ganglia / Q000166:cytology / Q000187:drug effects; D008974:Mollusca / Q000502:physiology*; D009490:Neurosecretory Systems / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D012110:Reserpine / Q000494:pharmacology*; D014882:Water-Electrolyte Balance / Q000187:drug effects*
chemical_list: D012110:Reserpine; D002746:Chlorpromazine