[Effect of urea on aggregation of immunoglobulins in water solutions].
The methods of molecular light scattering and of gel filtration were used to study the degree of urea-induced desaggregation of immunoglobulin (IgG) molecules preaggregated by heating. Urea was shown to desaggregate considerably (70--80%) protein IgG aggregates. The data obtained suggest an important role of hydrophobic interactions in the immunoglobulin aggregation.
D007074:Immunoglobulin G; D008027:Light; D046911:Macromolecular Substances; D012542:Scattering, Radiation; D014508:Urea; D014867:Water
D007074:Immunoglobulin G; D046911:Macromolecular Substances; D014867:Water; D014508:Urea
Vliianie mocheviny na agregatsiiu immunoglobulinov v vodnykh rastvorakh.