A possible preferential inhibition of chemotaxis of polymorphonuclear neutrophils by a chemical modification.
The modification of neutrophils with amino group blocking reagents of different chemical specificities showed that dansyl chloride caused inhibition of chemotaxis without suppression of random movement. Dansylated neutrophils, like control cells, ingested bacteria. Neither the stimulated cyanide-insensitive respiration, nor lactate production during phagocytosis, was affected significantly by dansylation as compared with the inhibition of directed movement.
D000096:Acetone / Q000494:pharmacology; D000818:Animals; D002633:Chemotaxis / Q000187:drug effects*; D003619:Dansyl Compounds / Q000494:pharmacology; D005450:Fluorescamine / Q000494:pharmacology; D005998:Glycine / Q000494:pharmacology; D006168:Guinea Pigs; D007700:Kinetics; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology*; D014302:Trinitrobenzenesulfonic Acid / Q000494:pharmacology
D003619:Dansyl Compounds; D000096:Acetone; D005450:Fluorescamine; D014302:Trinitrobenzenesulfonic Acid; D005998:Glycine