[State of the microcirculation in myocardial ischemia and its alterations after depositing bioresorbing microspheres of Sephadex in the coronary bed].
It is shown that the diffusion capacity of the capillary channel diminishes in myocardial ischemia. In unchanged or increased capillary permeability this effect may only be explained by a functional shunt of the affected cardiac area. Intracoronary administration of a carrier of biologically active substances in the form of microspheres of modified Sephadex does not aggravate irregularity in the blood supply to the zone of ischemia, which is evidence of the adequacy of the organ reserves of the functional shunt in this situation.
D000042:Absorption; D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects; D003327:Coronary Disease / Q000188:drug therapy / Q000503:physiopathology*; D003331:Coronary Vessels; D003911:Dextrans / Q000008:administration & dosage*; D004058:Diffusion; D004285:Dogs; D008833:Microcirculation / Q000187:drug effects / Q000503:physiopathology; D008863:Microspheres
D003911:Dextrans; C025614:sephadex
Sostoianie mikrotsirkuliatsii pri ishemii miokarda i ee izmeneniia posle deponirovaniia v koronarnom rusle bioarassasyvaiushchikhsia mikrosfer sefadeksa.