title: Assay of 4-hydroxy-3-methoxyphenylacetic (homovanillic) acid by liquid chromatography with electrochemical detection.
abstract: We describe a method for the assay of urinary 4-hydroxy-3-methoxyphenylacetic acid (homovanillic acid), based on its separation on a microparticulate reversed-phase column and direct electrochemical detection. Patients with neuroblastoma, pheochromocytoma, and Parkinson's disease have increased amounts of this compound in their urine.
mesh_terms: D000328:Adult; D002853:Chromatography, Liquid / Q000379:methods*; D004563:Electrochemistry; D006719:Homovanillic Acid / Q000652:urine*; D006801:Humans; D009447:Neuroblastoma / Q000652:urine; D010300:Parkinson Disease / Q000652:urine; D010648:Phenylacetates / Q000652:urine*; D010673:Pheochromocytoma / Q000652:urine; D012016:Reference Values
chemical_list: D010648:Phenylacetates; D006719:Homovanillic Acid