N-formyl-L-methionine deformylase activity in human leucocytes and platelets.
Extracts of human neutrophils, lymphocytes and platelets enzymically deformylate N-formyl-L-methionine. Enzyme activity is stimulated by Co2+, inhibited by bivalent-cation chelators and unaffected by inhibitors of serine, thiol and carboxyl proteinases. Leucocyte or platelet N-formylmethionine deformylase may be important in modulation of neutrophil responses to chemoattractant formylmethionyl peptides or similar compounds.
D000581:Amidohydrolases / Q000097:blood*; D001792:Blood Platelets / Q000201:enzymology*; D003035:Cobalt / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D007962:Leukocytes / Q000201:enzymology*; D009239:N-Formylmethionine
D004791:Enzyme Inhibitors; D003035:Cobalt; D009239:N-Formylmethionine; D000581:Amidohydrolases; C020150:formylmethionine deformylase