Synthesis of Benzo-15-crown-5 polyethers, anticoccidial ionophore analogues.
Synthesis of eight benzo-15-crown-5 derivatives I (R = H, CO2Me, CO2H, Me; R1 = H, CO2H, CO2Me, CHO, CH=CHCO2H, CH2CH2CO2H) designed as rigid cyclic analogues of the anticoccidial ionophores is described. No anticoccidial activity was observed in chickens, but moderate activity in tissue culture was found for I (R = Me, R1 = H; R = R1 = H) and dibenzo-18-crown-6.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D002645:Chickens; D003048:Coccidiosis / Q000188:drug therapy; D003049:Coccidiostats / Q000138:chemical synthesis* / Q000627:therapeutic use; D004988:Ethers, Cyclic / Q000138:chemical synthesis* / Q000494:pharmacology; D007476:Ionophores / Q000138:chemical synthesis*; D008297:Male
D003049:Coccidiostats; D004988:Ethers, Cyclic; D007476:Ionophores