The antiheparin effect of alpha1-acid glycoprotein probably due to steric hindrance of the heparin-thrombin interaction.
D000813:Anilides / Q000378:metabolism; D000818:Animals; D000990:Antithrombin III / Q000494:pharmacology; D001665:Binding Sites; D001780:Blood Coagulation Tests; D002417:Cattle; D002846:Chromatography, Affinity; D002850:Chromatography, Gel; D004591:Electrophoresis, Polyacrylamide Gel; D006493:Heparin / Q000378:metabolism*; D006494:Heparin Antagonists / Q000494:pharmacology*; D006801:Humans; D009961:Orosomucoid / Q000494:pharmacology*; D013237:Stereoisomerism; D013917:Thrombin / Q000378:metabolism*
D000813:Anilides; D006494:Heparin Antagonists; D009961:Orosomucoid; D000990:Antithrombin III; D006493:Heparin; D013917:Thrombin