Increase of IgA-bearing peripheral blood lymphocytes in children with Henoch-Schoenlein purpura.
Aberration of IgA-bearing peripheral blood lymphocytes in children with Henoch-Schoenlein purpura has been investigated. Eighteen children with Henoch-Schoenlein purpura demonstrated a marked increase of IgA-bearing lymphocytes in peripheral blood during the acute phase of the disease. The levels of IgA-bearing lymphocytes returned to the normal levels after the acute symptoms of Henoch-Schoenlein purpura had subsided. However, in patients who developed purpura nephritis, the increased levels of IgA-bearing lymphocytes in peripheral blood were retained after the disappearance of purpura, and lasted for more than 12 months. It is concluded that the monitoring of IgA-bearing peripheral blood lymphocytes is useful for the screening of patients with Henoch-Schoenlein purpura and purpura nephritis.
D000293:Adolescent; D002462:Cell Membrane / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005921:Glomerulonephritis / Q000209:etiology / Q000276:immunology; D006417:Hematuria / Q000276:immunology; D006801:Humans; D011695:IgA Vasculitis / Q000150:complications / Q000235:genetics / Q000276:immunology*; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D010375:Pedigree; D013997:Time Factors; D014357:Trypsin
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D014357:Trypsin