[Bradykinin, morphine and naloxone interaction on the sensorimotor cortical neuron level].
In experiments on awake rabbits the effect of bradykinin, morphine and naloxone (applied by means of microiontophoresis) on sensomotor cortical neurons was studied. Bradykinin increased the discharge frequency in the majority of neurons. Morphine inhibited the neuronal activity. Bradykinin had no activating effect in the presence of morphine. Naloxone eliminated morphine depressing effect and restored the neuronal reaction to bradykinin. According to the data obtained it is suggested that bradykinin interacts with opiate receptors in the brain.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001920:Bradykinin / Q000494:pharmacology*; D004347:Drug Interactions; D007478:Iontophoresis; D009020:Morphine / Q000494:pharmacology*; D009044:Motor Cortex / Q000187:drug effects*; D009270:Naloxone / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects*; D009619:Nociceptors / Q000187:drug effects; D011817:Rabbits; D013003:Somatosensory Cortex / Q000187:drug effects*
D009270:Naloxone; D009020:Morphine; D001920:Bradykinin
Vzaimodeĭstvie bradikinina, morfina i naloksona na urovne neĭronov sensomotornoĭ kory.