The side of action of bronchodilating drugs (beta 2-stimulators) on antigen-induced bronchoconstriction.
The prophylactic effect of a sympathicomimetic drug (Fenoterol) was tested separately for the upper and the lower respiratory tract on 14 boxer dogs exposed to antigen challenge. In the lower airways, a restricted short-lasting diminution of bronchoconstriction was observed when both antigen and Fenoterol were administered to these airways. Administration of Fenoterol to the upper respiratory tract showed a long-lasting strong local effect in prevention of antigen-induced bronchoconstriction. There is a strong long-lasting effect of sympathicomimetic bronchodilators on the sensoric part of the reflex way into the airways. There is, with similar dosages, a weak short-lasting direct effect of these drugs on bronchial muscles.
D000336:Aerosols; D000402:Airway Obstruction / Q000188:drug therapy; D000818:Animals; D000941:Antigens / Q000009:adverse effects; D001986:Bronchial Spasm / Q000188:drug therapy*; D004285:Dogs; D004983:Ethanolamines / Q000494:pharmacology*; D005280:Fenoterol / Q000494:pharmacology* / Q000627:therapeutic use; D012143:Respiratory Physiological Phenomena
D000336:Aerosols; D000941:Antigens; D004983:Ethanolamines; D005280:Fenoterol