[Treatment of experimental osteomyelitis with dimexid, protease inhibitors and proteolytic enzymes].
Acute osteomyelitis of the tibial bone was induced in 100 young rabbits. Four series of experiments were conducted. Treatment of osteomyelitis began from the 15th day after challenge. Antibiotics were used for the treatment of all the animals. The best results were obtained in the series where rabbits were injected dimexid intraosseously in addition to antibiotics. Unsatisfactory results were obtained in the series where the animals were given tripsin in addition to antibiotics. In 14 rabbits extensive phlegmonas developed and 8 rabbits died. Roentgenograms revealed extensive destruction of bones.
D000208:Acute Disease; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D004121:Dimethyl Sulfoxide / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D010019:Osteomyelitis / Q000188:drug therapy*; D011480:Protease Inhibitors / Q000627:therapeutic use*; D011817:Rabbits; D014357:Trypsin / Q000627:therapeutic use*
D000900:Anti-Bacterial Agents; D011480:Protease Inhibitors; D014357:Trypsin; D004121:Dimethyl Sulfoxide
Lechenie éksperimental'nogo osteomielita dimeksidom, ingibitorami proteaz i proteoliticheskimi fermentami.