Cyclosporins: immunosuppressive agents with antitumor activity.
Initial screening of the 2 recently developed immunosuppressive agents, cyclosporin A and cyclosporin C, in 11 murine transplantable neoplasms revealed significant increase of lifespan with long-term survivors after i.p. injection to the ascites tumors, Taper liver, Sarcoma 180J and Ehrlich.
D000818:Animals; D000970:Antineoplastic Agents; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007939:Leukemia L1210 / Q000188:drug therapy; D008113:Liver Neoplasms / Q000188:drug therapy; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D010456:Peptides, Cyclic / Q000627:therapeutic use*; D012510:Sarcoma 180 / Q000188:drug therapy
D000970:Antineoplastic Agents; D007166:Immunosuppressive Agents; D010456:Peptides, Cyclic