[Analysis of the mechanism of amplitude change in Pacinian corpuscle receptor potential in a solution with a decreased calcium ion concentration].
The effect of Ca2+-free solution on the amplitude increase in the receptor potential (RP) of Pacinian corpuscles was studied using external perfusion technique. The RP amplitude increased in Ca2+-free solution. It was blocked after addition of 10-20 mM of tetraethylamonium. A temporary increase in the RP amplitude is seen in the solution with 0.2 mM of 2.4-dinitrophenol. Sensitivity of the receptor membrane to mechanical stimuli does not change in Ca2+-free solution. It is suggested that near the mechanosensitive ionic canal of Pacinian corpuscle receptor membrane the fixed negative charges which could influence the "gate" system state of the mechanosensitive canal are absent.
D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D002413:Cations, Divalent; D002415:Cats; D004140:Dinitrophenols / Q000494:pharmacology; D066298:In Vitro Techniques; D008465:Mechanoreceptors / Q000187:drug effects*; D008564:Membrane Potentials / Q000187:drug effects; D010141:Pacinian Corpuscles / Q000187:drug effects*; D012996:Solutions; D013757:Tetraethylammonium Compounds / Q000494:pharmacology
D002413:Cations, Divalent; D004140:Dinitrophenols; D012996:Solutions; D013757:Tetraethylammonium Compounds; D002118:Calcium
Analiz mekhanizma izmeneniia amplitudy retseptornogo potentsiala telets Pachini v rastvore s ponizhennoĭ kontsentratsieĭ ionov kal'tsiia.