title: Modes of inhibition of activities of trypsin and chymotrypsin by potassium thiocyanate.
abstract: Potassium thiocyanate inhibited the activities of trypsin and chymotrypsin. The inhibition was mixed type on both enzymes with casein as substrate and on trypsin with tosyl-L-arginine methyl ester as substrate, but was uncompetitive on chymotrypsin with benzoyl-L-tyrosine p-nitroanilide as substrate.
mesh_terms: D002364:Caseins / Q000378:metabolism; D002918:Chymotrypsin / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013861:Thiocyanates / Q000494:pharmacology*; D014106:Tosylarginine Methyl Ester / Q000378:metabolism; D014357:Trypsin / Q000378:metabolism; D014361:Trypsin Inhibitors / Q000494:pharmacology*; D014443:Tyrosine / Q000031:analogs & derivatives / Q000378:metabolism
chemical_list: D002364:Caseins; D013861:Thiocyanates; D014361:Trypsin Inhibitors; D014443:Tyrosine; C022787:benzoyltyrosine 4-nitroanilide; D014106:Tosylarginine Methyl Ester; D002918:Chymotrypsin; D014357:Trypsin