Experimental acute pancreatitis: the changes in pancreatic oxygen consumption and the effect of Dextran 40.
A canine model was devised to measure the oxygen consumption of the pancreas in experimentally induced pancreatitis. Over the 120 minute investigation period the oxygen consumption fell by 63% in the presence of a diminishing pancreatic blood flow and constant arteriovenous percentage saturation across the pancreas. Dextran 40 has been previously shown to maintain the pancreatic circulation. Accordingly a second group of dogs was treated with Dextran 40 (1.5 ml/kg) 60 minutes after induction of the pancreatitis. This produced a significant increase in the pancreatic oxygen consumption and widening of the arteriovenous difference. Dextran 40 appears to reverse the hypoxia of the pancreas noted in acute experimental pancreatitis.
D000208:Acute Disease; D000818:Animals; D001158:Arteries; D003911:Dextrans / Q000008:administration & dosage / Q000494:pharmacology*; D004285:Dogs; D010101:Oxygen Consumption; D010179:Pancreas / Q000098:blood supply / Q000378:metabolism*; D010195:Pancreatitis / Q000378:metabolism* / Q000503:physiopathology; D014680:Veins
D003911:Dextrans