Protective role of ceruloplasmin in inflammation.
Experimental inflammation in copper (Cu)-deficient rats is greater than that induced in controls eating normal diet. Cu-supplementation of the Cu-deficient diet results in a reduced swelling, down to normal levels. Injection of the naturally occurring acute phase reactant, ceruloplasmin (Cp) a Cu-bearing serum protein, also results in reduction of experimental inflammation. Since a rise in serum Cp occurs in normal pregnancy this protective anti-inflammatory action of Cp is proposed as an explanation for the widely-observed phenomenon of spontaneous control of rheumatoid arthritis in pregnancy.
D000328:Adult; D000418:Albumins / Q000494:pharmacology; D000818:Animals; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D002570:Ceruloplasmin / Q000627:therapeutic use*; D003300:Copper / Q000097:blood / Q000172:deficiency; D005260:Female; D006801:Humans; D007249:Inflammation / Q000188:drug therapy*; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy; D051381:Rats; D014527:Uric Acid / Q000494:pharmacology
D000418:Albumins; D014527:Uric Acid; D003300:Copper; D002570:Ceruloplasmin