Absorption of boron after mouthwash treatment with Bocosept.
Healthy volunteers and patients with gingivitis were treated locally with the boron-containing bacteriostatic agent, Bocosept. Blood levels and urinary excretion of boron were examined by a spectrophotometric method. Blood concentrations after a single mouthwash with Bocosept slightly exceeded those after intake of 200 g raisins or a bottle of red wine. The blood levels during a one-week course of treatment showed a low rate of boron accumulation. The highest concentration was about 0.3 microgram B/ml, a level which does not seem to involve any risk of boron poisoning. The small amount taken up after mouthwash treatment with Bocosept does not appear to represent absorption by the oral mucosa. It seems more likely that the uptake of boron takes place in the intestine after ingestion of residual amounts from the mouth.
D000042:Absorption; D000328:Adult; D000891:Anti-Infective Agents, Local / Q000378:metabolism; D001881:Borates / Q000378:metabolism*; D001895:Boron / Q000097:blood / Q000378:metabolism*; D004338:Drug Combinations; D005638:Fruit; D006801:Humans; D008875:Middle Aged; D009067:Mouthwashes / Q000378:metabolism*; D013644:Tartrates / Q000378:metabolism; D014920:Wine
D000891:Anti-Infective Agents, Local; D001881:Borates; D004338:Drug Combinations; D009067:Mouthwashes; D013644:Tartrates; D001895:Boron