[Experimental and pharmacokinetic studies with gentamicin PMMA beads (author's transl)].
Gentamicin PMMA beads (PMMA = polymethylmethacrylate) represent a new form of local antibiotic therapy for treating chronic bone and soft tissue infections. Gentamicin is released in high concentrations from PMMA. The therapeutic efficacy of the beads was demonstrated in a model of bone infection in dogs. Sufficiently high tissue concentrations of gentamicin were measurable for a period of 4 months. A very good tolerance of the beads was demonstrated in dogs as well as in cell cultures. High gentamicin concentrations exceeding the MBC values of relevant pathogens were measurable in patients at the site of infection. Serum and urine concentrations were low and therefore toxic side effects are excluded.
D000818:Animals; D002908:Chronic Disease; D003692:Delayed-Action Preparations; D004285:Dogs; D005839:Gentamicins / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use*; D006801:Humans; D066298:In Vitro Techniques; D008689:Methacrylates; D010019:Osteomyelitis / Q000188:drug therapy; D011817:Rabbits; D014947:Wounds and Injuries / Q000188:drug therapy
D003692:Delayed-Action Preparations; D005839:Gentamicins; D008689:Methacrylates
Experimentelle und pharmakokinetische Untersuchungen mit Gentamycin-PMMA-Kugeln.