title: Changes in the inhibition of specific agglutination by plasma due to microvesicles released from human red cells during storage for transfusion.
abstract: The progressive appearance of erythrocyte antigenic activity in plasma from donations of human blood taken into acid citrate-dextrose (ACD) and stored at 4 degrees D for transfusion has been studied. It has been shown by specific inhibition tests that A, B, H and P1 activities are associated with membrane-bounded microvesicles which are released from the red cell membrane during the disc-echinocyte-spherocyte shape transformation. Although M group activity appears to be lost from the red cell membrane during storage, significant recovery on the microvesicles is not obtained even though these seem to contain the M and N group intrinsic protein, glycophorin.
mesh_terms: D000017:ABO Blood-Group System; D001803:Blood Transfusion; D002498:Centrifugation; D004912:Erythrocytes / Q000378:metabolism*; D006384:Hemagglutination; D006801:Humans; D007106:Immune Sera / Q000494:pharmacology; D008951:MNSs Blood-Group System; D008297:Male; D010127:P Blood-Group System; D010949:Plasma; D011309:Preservation, Biological
chemical_list: D000017:ABO Blood-Group System; D007106:Immune Sera; D008951:MNSs Blood-Group System; D010127:P Blood-Group System