Induction of aryl hydrocarbon hydroxylase by lymphocytes from women taking oral contraceptives.
The peripheral blood lymphocytes (PBL) from two female subjects were assayed for AHH induction 40 days prior to and 30 days during ingestion of progesterone and estrogen analogues as oral contraceptives. Three habitual users of oral contraceptives were also studied. No in vitro inhibition of AHH induction was observed as a consequence of the use of these hormone analogues. Values obtained for enzyme activity suggest a slight increase in AHH induction resulting from the use of oral contraceptives. Further studies with larger numbers of subjects are required before the apparent increase in enzyme inducibility can be considered significant.
D001189:Aryl Hydrocarbon Hydroxylases / Q000378:metabolism*; D003276:Contraceptives, Oral / Q000494:pharmacology*; D045166:Estradiol Congeners; D004997:Ethinyl Estradiol / Q000494:pharmacology; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism*; D008598:Menstruation; D009644:Norgestrel / Q000494:pharmacology; D010060:Ovulation / Q000187:drug effects; D011374:Progesterone / Q000031:analogs & derivatives
D003276:Contraceptives, Oral; D045166:Estradiol Congeners; D009644:Norgestrel; D004997:Ethinyl Estradiol; D011374:Progesterone; D001189:Aryl Hydrocarbon Hydroxylases