Perinatal naloxone: when does naloxone affect hyperalgesia?
Pregnant mice were treated with naloxone via subcutaneous implants, from about 5 days prior to parturition. At birth entire litters were cross-fostered so that groups of offspring were exposed to naloxone treated mothers; before birth, after birth to weaning, from about 5 days prior to birth to weaning, or not exposed to naloxone. When tested on a hot-plate at 50 days of age, females either prenatally treated or treated pre- and postnatally showed hyperalgesia to heat. For males, this effect was not evident. This sex difference may have been induced by the cross-fostering procedure.
D000375:Aging; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005260:Female; D006930:Hyperalgesia / Q000139:chemically induced*; D006941:Hyperesthesia / Q000139:chemically induced*; D008297:Male; D051379:Mice; D009270:Naloxone / Q000494:pharmacology*; D011930:Reaction Time / Q000187:drug effects; D012737:Sex Factors; D013997:Time Factors
D009270:Naloxone