Dependence of the guinea pig IgE and IgG1 immune responses on the inclusion of potassium in the preparation of alum adjuvant.
Primary immunization with alum prepared using AlK(SO4)2 and adjuvant enhanced IgE production in the guinea pig. Alum prepared from Al2 (SO4)3 showed greatly reduced IgE and IgG1 anti-EA titers. This variance in immunoglobulin titer was observed only in the guinea pig. Both rats and mice respond to alum preparations prepared from either AlK(SO4)2 or Al2(SO4)3 equally as well.
D000276:Adjuvants, Immunologic; D000534:Alum Compounds / Q000494:pharmacology*; D000535:Aluminum / Q000494:pharmacology*; D000818:Animals; D000917:Antibody Formation; D001200:Ascaris / Q000276:immunology; D006168:Guinea Pigs; D007073:Immunoglobulin E / Q000096:biosynthesis*; D007074:Immunoglobulin G / Q000096:biosynthesis*; D008297:Male; D051379:Mice; D010047:Ovalbumin / Q000276:immunology; D010323:Passive Cutaneous Anaphylaxis; D011188:Potassium / Q000494:pharmacology*; D051381:Rats
D000276:Adjuvants, Immunologic; D000534:Alum Compounds; D007074:Immunoglobulin G; D007073:Immunoglobulin E; D010047:Ovalbumin; D000535:Aluminum; D011188:Potassium