A latent gelatin specific proteinase of human leucocytes and its activation.
1. Gelatin specific proteinase (gelatinase) exists in human leucocytes extracts mainly in a latent form. 2. It is activated by different proteinases as well as by some chemicals (urea, NaSCN, HgCl2). 3. Non-proteolytic activation of latent gelatinase and the decreasing of its molecular weight associated with it strongly suggests that it is an enzyme-inhibitor complex.
D010450:Endopeptidases / Q000097:blood* / Q000494:pharmacology; D004789:Enzyme Activation / Q000187:drug effects; D005780:Gelatin; D006801:Humans; D007962:Leukocytes / Q000201:enzymology*; D008628:Mercury / Q000494:pharmacology; D013379:Substrate Specificity; D014508:Urea / Q000494:pharmacology
D014508:Urea; D005780:Gelatin; D010450:Endopeptidases; D008628:Mercury