title: Molecular basis for the irreversible inhibition of 4-aminobutyric acid:2-oxoglutarate and L-ornithine:2-oxoacid aminotransferases by 3-amino-1,5-cyclohexadienyl carboxylic acid (isogabaculline).
mesh_terms: D000612:4-Aminobutyrate Transaminase / Q000037:antagonists & inhibitors*; D000818:Animals; D003509:Cyclohexanecarboxylic Acids / Q000494:pharmacology*; D003514:Cyclohexylamines / Q000494:pharmacology; D004789:Enzyme Activation / Q000187:drug effects; D005968:Glutamate Decarboxylase / Q000037:antagonists & inhibitors; D007700:Kinetics; D051379:Mice; D009953:Ornithine-Oxo-Acid Transaminase / Q000037:antagonists & inhibitors*; D011732:Pyridoxal Phosphate / Q000494:pharmacology; D013696:Temperature; D013997:Time Factors; D000637:Transaminases / Q000037:antagonists & inhibitors*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D003509:Cyclohexanecarboxylic Acids; D003514:Cyclohexylamines; D005680:gamma-Aminobutyric Acid; D011732:Pyridoxal Phosphate; D000637:Transaminases; D009953:Ornithine-Oxo-Acid Transaminase; D000612:4-Aminobutyrate Transaminase; D005968:Glutamate Decarboxylase