[Regulation of the reaction rate of ATP synthesis in intact mitochondria].
High concentrations of respiration inhibitors are known to sharply decrease the membrane potential in mitochondria. The effect of relatively low concentrations of oxidative phosphorylation inhibitors on the value of membrane potential of intact mitochondria and on the rate of respiration and phosphorylation as well was studied. It has been found that within a certain concentration range the inhibitors of oxidative phsophorylation--malonic acid, sodium cyanide m-chlorophenyl hydrozonecarbonylcyanide, sharply decrease the phosphorylation rate (by 70 divided by 90%) but do not practically a affect the membrane potential value of intact mitochondria in the state 3 according to Chance.
D000255:Adenosine Triphosphate / Q000096:biosynthesis*; D000818:Animals; D003486:Cyanides / Q000494:pharmacology; D066298:In Vitro Techniques; D008314:Malonates / Q000494:pharmacology; D008564:Membrane Potentials / Q000187:drug effects; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D012966:Sodium Cyanide / Q000494:pharmacology; D014475:Uncoupling Agents / Q000494:pharmacology
D003486:Cyanides; D008314:Malonates; D014475:Uncoupling Agents; D000255:Adenosine Triphosphate; D012966:Sodium Cyanide
Reguliatsiia skorosti reaktsiĭ sinteza ATF v intaktnykh mitokhondriiakh.