Candidiasis: detection by gas-liquid chromatography of D-arabinitol, a fungal metabolite, in human serum.
D-Arabinitol was identified as a major metabolite of Candida species in human subjects. Gas-liquid chromatography was used to measure the concentration of D-arabinitol in serum. The study included subjects who were healthy and cancer patients who had proven invasive candidiasis or were colonized with Candida. D-Arabinitol concentrations greater than 1.0 microgram per milliliter were found in serum from patients with invasive infection. This technique may prove valuable in the diagnosis of invasive candidiasis.
D001089:Arabinose / Q000031:analogs & derivatives / Q000097:blood; D002177:Candidiasis / Q000097:blood / Q000175:diagnosis*; D002849:Chromatography, Gas; D006801:Humans; D013058:Mass Spectrometry; D013402:Sugar Alcohols / Q000097:blood*
D013402:Sugar Alcohols; D001089:Arabinose; C014999:arabitol