[Age and blood coagulation features in ischemic strokes].
Extensive coagulogramms and thromboelastogramms were analysed in 775 patients who had ischemic brain strokes in the age up to 45 years (I group), 46-60 (II group) and over 60 (III group). In patients of the II and III group thrombogenic hypercoagulant tendencies compared to that of the young age were more distinct and were mainly conditioned by depressions of the anticoagulative link in the anticoagulant blood system. In patients younger than 45, despite more rapid formation of procoagulants, there was an earlier and more expressed activation of fibrinolysis and an increase of the concentration of free heparin in the blood. These changes of coagulation in an ischemic stroke have a compensatory significance and can be explained by a prevalent adaptive tendency of changes in metabolism in young age, providing an adaptation of the organism in the period of stress.
D000367:Age Factors; D001777:Blood Coagulation; D002545:Brain Ischemia / Q000097:blood*; D005340:Fibrinogen / Q000032:analysis; D005342:Fibrinolysis; D006493:Heparin / Q000097:blood; D006801:Humans; D008875:Middle Aged; D013916:Thrombelastography; D014914:Whole Blood Coagulation Time
D005340:Fibrinogen; D006493:Heparin
Vozrastnye osobennosti gemokoaguliatsii pri ishemicheskom mozgovom insul'te.