title: [Mechanisms of detecting organic cholephilic anions in man: comparative studies on plasma depuration of rifamycin-SV. Interference of nicotinic acid and phenobarbital].
abstract: We have studied plasmatic half-life of R-SV administered alone and in association with nicotinic acid, before and after treatment with phenobarbital, in 10 normobilirubinaemic subjects and in 10 patients Gilbert's syndrome, used like controls. Ouer results confirm the existence of some alterations of drug-metabolism produced by associated administration of other drugs, in both healthy and hyperbilirubinaemic subjects, and in these one even more.
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005878:Gilbert Disease / Q000097:blood; D006801:Humans; D008099:Liver / Q000378:metabolism; D008297:Male; D008657:Metabolic Clearance Rate; D009539:Nicotinic Acids / Q000097:blood* / Q000378:metabolism / Q000494:pharmacology; D010634:Phenobarbital / Q000097:blood* / Q000378:metabolism / Q000494:pharmacology; D012294:Rifamycins / Q000037:antagonists & inhibitors / Q000097:blood*
chemical_list: D009539:Nicotinic Acids; D012294:Rifamycins; D010634:Phenobarbital
vernacular_title: Meccanismi di captazione di anioni organici colefili nell'uomo: osservazioni comparative sulla depurazione plasmatica di rifamicina-SV. Interferenza di acido nicotinico e fenobarbital.