[Study of the nature and mechanism of biosynthesis of nonspecific immunoglobulins].
Mice were immunized with Vi-antigen. Spleen cells, removed at different time after immunization, were cultivated in Eagle medium, containing glycine-14C. The biosynthesis of antibodies to Vi-antigens, autoantibodies to mouse IgG and antigen-dependent non-specific immunoglobulins (NigG) were determined by means of specific immunosorbents. Immunization of mice with Vi-antigen resulted in a sharp increase in antigen-dependent NIgG formation. Thus, this protein biosynthesis takes place not only during immunization with thymus-dependent antigens, but also in response to the thymus-independent antigen. It is shown that the synthesized antigen-dependent NIgG were not autoantibodies to self mouse IgG.
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology; D001323:Autoantibodies / Q000096:biosynthesis; D002478:Cells, Cultured; D005260:Female; D007136:Immunoglobulins / Q000096:biosynthesis*; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D012485:Salmonella typhi / Q000276:immunology; D013154:Spleen; D013997:Time Factors
D000942:Antigens, Bacterial; D001323:Autoantibodies; D007136:Immunoglobulins
Izuchenie prirody i mekhanizma sinteza nespetsificheskikh immunoglobulinov.