[Antibody-dependent cytotoxic activity of the lymphocytes and the cytological characteristics of immune cell complexes in vitro].
Bovine blood lymphocytes showed a high antibody-dependent (AD) cytotoxicity against target cultured L cells. The cytological analysis of immune cellular complexes, formed by affector lymphocytes with target cells during the cytotoxic reaction in vitro, revealed that adsorption of AD lymphocytes to target cells was completed within the first hours of incubation. Temporal parameters of contact between effector and target cells and dissociation of adsorbed lymphocytes varied widely, but after 48 hours of incubation the number of immune cellular complexes decreased by 5.6%. The morphological modification of AD effector lymphocytes during interaction with target cells is described.
D000327:Adsorption; D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity; D002417:Cattle; D002448:Cell Adhesion; D003601:Cytotoxicity Tests, Immunologic / Q000379:methods; D005260:Female; D007106:Immune Sera / Q000302:isolation & purification; D007111:Immunity, Cellular; D007114:Immunization; D007694:Killer Cells, Natural / Q000276:immunology; D007739:L Cells / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology*; D011817:Rabbits
D007106:Immune Sera
Zavisimaia ot antitel tsitotoksicheskaia aktivnost' limfotsitov i tsitologicheskaia kharakteristika immunnykh kletochnykh kompleksov in vitro.