Effect of alpha- and beta-blockers on ethanol metabolism.
The acute administration of propranolol or phentolamine resulted in a small (16-19%) but significant reduction in the rate of ethanol disappearance in vivo in the naive Wistar rat. A reduction of essentially similar magnitude was also observed in ethanol-treated rats and pair-fed (sucrose) control animals, following the administration of these blockers.
D000428:Alcohol Drinking; D000818:Animals; D000431:Ethanol / Q000378:metabolism*; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D010646:Phentolamine / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats
D000431:Ethanol; D011433:Propranolol; D010646:Phentolamine