Inhibition of polymorphonuclear leukocyte chemotaxis by streptokinase-streptodornase.
Leukotaxis of circulating polymorphonuclear leukocytes (PMN's) appears to be a critical step in the generation of local inflammatory reactions. The present studies demonstrate a reversible, dose-dependent inhibition of PMN chemotaxis by streptokinase-streptodornase (SK-SD). This inhibition does not appear to depend upon the presence of lymphocytes or the release of chemokinetic humoral factors and phagocytic and bactericidal capacities of PMN's are unaffected by the doses of SK-SD employed.
D002464:Cell Migration Inhibition; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007249:Inflammation / Q000209:etiology; D008222:Lymphokines / Q000096:biosynthesis; D009504:Neutrophils / Q000187:drug effects; D010587:Phagocytosis; D013299:Streptodornase and Streptokinase / Q000494:pharmacology*; D015054:Zymosan / Q000494:pharmacology
D008222:Lymphokines; D015054:Zymosan; D013299:Streptodornase and Streptokinase