Dynamic phase-shifts between theta generators in the rat hippocampus.
Winson [13] reported on two independent phase-reversed generators in the rat hippocampus. In the present study the synchrony between the two generators was investigated during the sleep-wakefulness cycle and during a behaviour-dependent discriminative learning task. Electrical activities derived from the CA 1 region and dentate gyrus were in phase during slow wave sleep but phase-reversed during the awake state and paradoxical sleep. The degree of phase-reversal was significantly higher during running than during lever pressing. These findings demonstrate that substantial changes occur within the hippocampal circuitry during dynamic shifts of behaviour.
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D004569:Electroencephalography; D006624:Hippocampus / Q000502:physiology*; D008124:Locomotion; D008297:Male; D009043:Motor Activity; D051381:Rats; D012890:Sleep / Q000502:physiology; D013826:Theta Rhythm