Foetal plasma magnesium levels during maternal hypo- or hypermagnesaemia in ewes.
1. The influence of maternal hypo- or hypermagnesaemia of foetal plasma magnesium levels was studied in pregnant ewes between the 120th and the 145th day of gestation using a permanent catheter inserted in utero into the left aorta of the foetus on the 115th day of gestation. 2. In seven ewes, carrying eleven foetuses, the injection of 1 alpha-hydroxycholecalciferol induced a hypomagnesaemia which lasted 72 h. This had no significant effect on foetal plasma Mg levels. 3. In five ewes, carrying six foetuses, hypermagnesaemia induced by a 2 h magnesium chloride infusion had no significant effect on foetal plasma Mg levels. 4. These results provide evidence that in sheep during the last 20 d of gestation the foetal regulation of plasma Mg is independent of the maternal plasma Mg levels.
D000818:Animals; D002118:Calcium / Q000097:blood; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D005865:Gestational Age; D006887:Hydroxycholecalciferols / Q000494:pharmacology; D008274:Magnesium / Q000097:blood* / Q000494:pharmacology; D008431:Maternal-Fetal Exchange / Q000187:drug effects*; D010758:Phosphorus / Q000097:blood; D011247:Pregnancy; D011409:Propylene Glycols; D012756:Sheep / Q000378:metabolism*; D014427:Twins
D006887:Hydroxycholecalciferols; D011409:Propylene Glycols; D010758:Phosphorus; D008274:Magnesium; D002118:Calcium