title: [Chronic measles neuroinfection in Syrian hamsters].
abstract: Measles neuroinfection was studied in 3-week Syrian hamsters inoculated intracerebrally with the neurovirulent Edmonston-42 strain of measles virus. The infectious virus was shown to be recoverable from the animals' brains both early after infection (up to 16 days) and at later intervals (28--63 days). At the same intervals (up to 69 days), measles antigen was demonstrated in brain impressions. All the animals under study had RNA-containing inclusions in some cells, slight cellular infiltrates and some oedema. Brains of a number of animals showed moderate inflammatory changes, dystrophic lesions in neurons, and microglial proliferation. The influence of the age and general resistance to the pattern of the course of measles neuroinfection in Syrian hamsters was demonstrated.
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D001921:Brain / Q000276:immunology / Q000473:pathology; D002493:Central Nervous System Diseases / Q000276:immunology / Q000473:pathology*; D002908:Chronic Disease; D006224:Cricetinae; D007109:Immunity; D008457:Measles / Q000276:immunology / Q000473:pathology*; D008459:Measles virus / Q000276:immunology; D008647:Mesocricetus
chemical_list: D000956:Antigens, Viral
vernacular_title: Khronicheskaia korevaia neĭroinfektsiia u siriĭskikh khomiachkov.