title: Sensitive assay for determination of hydroxyzine in plasma and its human pharmacokinetics.
abstract: An assay suitable for hydroxyzine determination in human plasma following therapeutic doses was developed. The method involves GLC and chemical-ionization mass spectrometry of the acetate derivatives of hydroxyzine and of a pentadeuterated analog internal standard. Following administration of 100-mg single oral doses to normal male volunteers, peak plasma concentrations of approximately 80 ng/ml were observed; the half-life of drug removal was approximately 3 hr.
mesh_terms: D006207:Half-Life; D006801:Humans; D006919:Hydroxyzine / Q000097:blood*; D007408:Intestinal Absorption; D007700:Kinetics; D008297:Male; D008722:Methods
chemical_list: D006919:Hydroxyzine