Protection by trimipramine against gastric mucosal barrier dysfunction induced by ethanol + HC1 in rats.
The effects of trimipramine (5 mg . kg-1 . h-1 intravenously) on the changes in gastric mucosal function evoked by 20% ethanol + HCl has been stuided in rats. The magnitude of the changes in potential difference, ionic fluxes (H+, Na+, and K+), and mucosal lesion score induced by ethanol + HCl were significantly less in animals treated with trimipramine than in control animals. It is concluded that trimipramine decreases the gastric mucosal damage produced the ethanol + HCl in rats. This activity may be responsible, at least in part, for the beneficial effect of trimipramine treatment in peptic ulcer disease.
D000818:Animals; D003984:Dibenzazepines / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D000431:Ethanol; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects* / Q000503:physiopathology; D006851:Hydrochloric Acid; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000517:prevention & control; D014299:Trimipramine / Q000494:pharmacology* / Q000627:therapeutic use
D003984:Dibenzazepines; D000431:Ethanol; D014299:Trimipramine; D006851:Hydrochloric Acid