Effects of 1,3-diaminopropane on testosterone induced hypertrophy and polyamine synthesis in mouse kidney.
The effects of prolonged treatment with 1,3-diaminopropane, a structural analogue of putrescine, on polyamine metabolism and growth in kidney tissue, were studied in mice in which renal hypertrophy was induced by testosterone treatment. Injections of 1,3-diaminopropane resulted in an almost total suppression of the testosterone induced stimulation of ornithine decarboxylase activity and prevented the accumulation of putrescine and spermidine in the kidneys. Renal spermine concentration was even lowered. Administration of 1,3-diaminopropane effectively prevented the testosterone induced increase in renal weight and RNA. In mice receiving 1,3-diaminopropane proteinuria was observed and histological examination revealed renal damage. Due to the nephrotoxic action of 1,3-diaminopropane caution is essential in relating the prevention of renal hypertrophy and the inhibition of polyamine synthesis.
D012437:Adenosylmethionine Decarboxylase / Q000378:metabolism; D000818:Animals; D002369:Castration; D004247:DNA / Q000378:metabolism; D003959:Diamines / Q000494:pharmacology*; D006984:Hypertrophy; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D051379:Mice; D009955:Ornithine Decarboxylase / Q000378:metabolism; D011073:Polyamines / Q000096:biosynthesis*; D012313:RNA / Q000378:metabolism; D013739:Testosterone / Q000494:pharmacology*
D003959:Diamines; D011073:Polyamines; D013739:Testosterone; D012313:RNA; D004247:DNA; C009475:trimethylenediamine; D009955:Ornithine Decarboxylase; D012437:Adenosylmethionine Decarboxylase