The protective effect of steroid treatment on lysosomal enzymes after cold lesion of the cat brain.
The effect of posttraumatic steroid treatment (6-methylprednisolone) on the stability of lysosomal membranes in the cat brain is studied. The share of free activity of the lysosomal enzymes beta-glucuronidase and N-acetylhexosaminidase indicates the grade of membrane stability. The results demonstrate an increased stability of lysosomal membranes in grey as well as in white matter after posttraumatic steroid treatment. This regarded as an important aspect of the protective effects of steroid treatment in posttraumatic brain edema.
D000818:Animals; D001929:Brain Edema / Q000517:prevention & control*; D002415:Cats; D003080:Cold Temperature; D005966:Glucuronidase / Q000032:analysis; D006596:Hexosaminidases / Q000032:analysis; D008247:Lysosomes / Q000201:enzymology*; D008566:Membranes; D008775:Methylprednisolone / Q000627:therapeutic use*
D006596:Hexosaminidases; D005966:Glucuronidase; D008775:Methylprednisolone