title: Metabolic adrenergic changes during submaximal exercise and in the recovery period in man.
abstract: The urinary excretion of dihydroxyphenylalanine (DOPA), catecholamines (CA) [dopamine (DA), norepinephrine (NE), and epinephrine (e)], their 3-O-methylated derivatives [3-O-methyldopamine (3-MT), normetanephrine (NMN), and metanephrine (MN)], and their deaminated metabolites [dihydroxyphenylacetic acid (DOPAC) and vanilmandelic acid (VMA)] was studied in six healthy men, at rest during short-term (15 min) or exhaustive submaximal exercise, and in the 2-h postexercise recovery period. During short-term exercise only NE and VMA excretions increased, whereas in postexercise period only DA output was enhanced. Exhaustive muscular work induced a rise in NE and E excretion during the test, and an increase in DA, NE, and NMN urinary levels during postexercise recovery, while the output of deaminated metabolites was unaltered. It is concluded that both release and synthesis of CA are stimulated by submaximal exercise, which induces, in addition to NE, a specific release of DA. A possible role of NE in lipid mobilization during recovery from exhaustive muscular work is evoked. The origin and role of released DA are also discussed.
mesh_terms: D015102:3,4-Dihydroxyphenylacetic Acid / Q000652:urine; D000328:Adult; D002395:Catecholamines / Q000378:metabolism*; D003846:Deoxyepinephrine / Q000652:urine; D004295:Dihydroxyphenylalanine / Q000652:urine; D004298:Dopamine / Q000652:urine; D004837:Epinephrine / Q000652:urine; D006801:Humans; D008297:Male; D008676:Metanephrine / Q000652:urine; D009638:Norepinephrine / Q000652:urine; D009647:Normetanephrine / Q000652:urine; D005082:Physical Exertion; D013564:Sympathetic Nervous System / Q000378:metabolism*; D014642:Vanilmandelic Acid / Q000652:urine
chemical_list: D002395:Catecholamines; D009647:Normetanephrine; D015102:3,4-Dihydroxyphenylacetic Acid; D008676:Metanephrine; D014642:Vanilmandelic Acid; D004295:Dihydroxyphenylalanine; D003846:Deoxyepinephrine; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine