Tachyphylactic action of high doses of pentagastrin.
The study of the human LES was performed with manometrical methods for atropine action on gastrine tachyphylaxis. Our study points out that there is a complex self regulating neuronal circuit in the LES contraction. We discuss some hypothesis for the LES control. In particular ACh could activate an inhibitory adrenergic muscarinic receptor.
D000328:Adult; D001285:Atropine / Q000494:pharmacology; D004943:Esophagogastric Junction / Q000187:drug effects*; D006801:Humans; D007275:Injections, Intravenous; D009119:Muscle Contraction / Q000187:drug effects; D010418:Pentagastrin / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D013618:Tachyphylaxis
D001285:Atropine; D010418:Pentagastrin