title: Rhinoscopical findings in nickel workers, with special emphasis on the influence of nickel exposure and smoking habits.
abstract: Rhinoscopy and X-ray examination were performed on 318 nickel workers and 57 controls, to study the significance of these methods in detecting cancerous and precancerous mucosal changes. The clinical and radiological findings were compared with histopathological data and mucosal nickel concentrations determined in nasal biopsy material from the middle turbinate, with duration of nickel exposure, and with tobacco smoking habitl changes (43%) than the controls (26%), (0.01 less than P less than 0.02), mainly due to differences in frequency of hyperplastic rhinitis. Thirteen nickel workers (4%) had nasal polyps. Two of these cases, both employed at the nickel refinery for 28 years, appeared to have nasal carcinoma, according to histological examination. No distinct association was established between rhinoscopical findings and epithelial dysplasia found by histological examination. The explanatory values for the rhinoscopical findings of different factors, such as working category age, duration of nickel exposure, grams tobacco smoked per week, and nickel content of nasal mucosa, were evaluated by applying a stepwise multiple regression analysis. Number of years from first employment at the nickel refinery and tobacco consumption were the only explanatory factors that showed a statistically significant correlation to the rhinoscopical findings. The radiological examination revealed few characteristics findings. Chemical analysis of cigarettes handrolled by nickel workers showed high nickel concentrations compared with non-contaminated cigarettes.
mesh_terms: D000328:Adult; D000368:Aged; D004724:Endoscopy; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D006965:Hyperplasia; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000032:analysis / Q000187:drug effects* / Q000473:pathology; D009298:Nasal Polyps / Q000139:chemically induced*; D009532:Nickel / Q000009:adverse effects* / Q000032:analysis / Q000378:metabolism; D009669:Nose Neoplasms / Q000139:chemically induced*; D009784:Occupational Diseases / Q000139:chemically induced*; D010256:Paranasal Sinuses / Q000000981:diagnostic imaging; D011859:Radiography; D012852:Sinusitis / Q000139:chemically induced; D012907:Smoking / Q000150:complications*; D013997:Time Factors
chemical_list: D009532:Nickel