Simultaneous quantitative estimates of several isotopically labelled substances in the picogram range with selected ion monitoring.
The use of a model developed by the authors for the simultaneous quantitative determination of several isotopically labelled substances of the same chemical structure is described in detail for a two substance system. A computational flow chart is included. An example using natural estradiol and 4-[14C] labelled estradiol with manifold deuterated estradiol as an internal standard is presented. The basis of the model is discussed.
D002849:Chromatography, Gas; D003903:Deuterium; D004958:Estradiol / Q000032:analysis*; D013058:Mass Spectrometry / Q000379:methods*
D004958:Estradiol; D003903:Deuterium