Further evidence for independent segregation of the HLA system and a structural gene for the sixth component of complement (C6).
Previous studies have shown conflicting results with respect to the relationship between C6 deficiency and the HLA system. The present investigation of two kinships, in which C6 deficiency was associated with the expression of an amorphic (or silent) C6 allele, has provided further evidence for the genetic independence of a structural C6 locus and the HLA system.
D000328:Adult; D000483:Alleles; D002648:Child; D003183:Complement C6 / Q000172:deficiency / Q000235:genetics*; D005260:Female; D005796:Genes; D008040:Genetic Linkage; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D008297:Male; D010375:Pedigree; D011995:Recombination, Genetic
D003183:Complement C6; D006680:HLA Antigens