Rectal aspirin--absorption and antipyretic effect.
Rectal acetylsalicylic acid was given to 14 children who had undergone open heart surgery. The effect on their temperatures was similar whether 15--30 or 30--50 mg/kg was given. Either dose was more effective than no treatment. The greatest fall in temperature occurred after 4 or 5 hours. Rectal aspirin in a triglyceride base is effective in lowering postoperative temperature. It should also be of use in treating other fevers. A dose of 20--25 mg/kg is suggested.
D000293:Adolescent; D001241:Aspirin / Q000008:administration & dosage* / Q000378:metabolism / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D005334:Fever / Q000188:drug therapy*; D006801:Humans; D007408:Intestinal Absorption; D011183:Postoperative Complications / Q000188:drug therapy*; D012007:Rectum; D013488:Suppositories
D013488:Suppositories; D001241:Aspirin