Solution properties of sulfated monohydroxy bile salts. Relative insolubility of the disodium salt of glycolithocholate sulfate.
Physical-chemical properties of the major sulfated monohydroxy bile salts of man are described. In general, the sulfates are significantly more water-soluble than the non-sulfated species as a result of lower critical micellar temperatures, high aqueous monomeric solubilities and critical micellar concentrations. Nevertheless, at 37 degrees C the disodium salt of glycolithocholate sulfate, the major monohydroxy bile salt of man is not more soluble than its non-sulfated form. Since aqueous solubility correlates inversely with the cholestatic potential of bile salts, our results suggest that this sulfate may be potentially hepatoxic. Micellar solubility of phosphatidylcholine and cholesterol by the majority of non-sulfated and sulfated monohydroxy bile salts is slight. Nonetheless, phosphatidylcholine is very well solubilized by taurolithocholate sulfate but cholesterol solubility is not increased appreciably. Cholesterol saturation in model bile systems of taurochenodeoxycholate and phosphatidylcholine is impaired by the addition of sulfated lithocholate conjugates but with physiological bile salt compositions this reduction is not significant.
D001647:Bile Acids and Salts / Q000032:analysis*; D002784:Cholesterol / Q000032:analysis; D006000:Glycocholic Acid / Q000031:analogs & derivatives* / Q000032:analysis; D006801:Humans; D008095:Lithocholic Acid / Q000031:analogs & derivatives* / Q000032:analysis; D010713:Phosphatidylcholines / Q000032:analysis; D012995:Solubility; D013464:Sulfuric Acids / Q000032:analysis; D013658:Taurolithocholic Acid / Q000032:analysis; D013696:Temperature
D001647:Bile Acids and Salts; D010713:Phosphatidylcholines; D013464:Sulfuric Acids; D013658:Taurolithocholic Acid; D008095:Lithocholic Acid; D002784:Cholesterol; D006000:Glycocholic Acid