[Antineoplastic effects of violamycins depending on the number of sugar-components in the molecule (author's transl)].
Violamycin B, an antibiotic-complex, inhibited the growth of Sarcoma 180 in a well defined manner. The products Violamycin A, BII, and BI obtained by gelfiltration, were tested against the lymphoid Leukemia L1210. The results showed an increase of the toxicity and, simultaneously, a decrease of the antineoplastic effect, depending on the number of the sugar-components.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis* / Q000627:therapeutic use / Q000633:toxicity; D002241:Carbohydrates / Q000032:analysis*; D005260:Female; D007939:Leukemia L1210 / Q000188:drug therapy*; D008297:Male; D051379:Mice; D012510:Sarcoma 180 / Q000188:drug therapy
D000900:Anti-Bacterial Agents; D002241:Carbohydrates
Zur antineoplastischen Wirkung der Violamycine in Abhängigkeit von den im Molekül enthaltenen Zuckern.