The estimation of the survival rate of tetanus-intoxicated mice. A model for screening anti-tetanus drugs.
The estimation of the survival rate of tetanus-intoxicated mice is suggested to be a useful animal model for assaying the anti-tetanus potency of drugs. This model was tested with the four central depressants phenobarbitone, chlorpromazine, diazepam and halothane. In agreement with their clinical value, diazepam appeared to be the most, phenobarbitone the least effective agent.
D000818:Animals; D002746:Chlorpromazine / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006221:Halothane / Q000494:pharmacology; D008297:Male; D051379:Mice; D010634:Phenobarbital / Q000494:pharmacology; D012640:Seizures / Q000503:physiopathology; D013742:Tetanus / Q000188:drug therapy*; D013743:Tetanus Antitoxin; D013744:Tetanus Toxin / Q000633:toxicity; D013997:Time Factors
D013743:Tetanus Antitoxin; D013744:Tetanus Toxin; D003975:Diazepam; D002746:Chlorpromazine; D006221:Halothane; D010634:Phenobarbital