[Morphine and promedol interaction with the plasma proteins of allergized rabbits].
It has been established that morphine interacts with albumins, alpha 2- and beta-globulins, while promedol with all globulin fractions and to a less measure with plasma albumins of the intact rabbit. Interaction of morphine and especially that of promedol with the same protein fractions of allergizated animals proceeds more actively and is characterized by a more pronounced formation of biological complexes with alpha 1-globulins. Decreased pharmacological activity of morphine and promedol coincides with intensification of their interaction with proteins.
D000698:Analgesia; D000818:Animals; D001798:Blood Proteins / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006968:Hypersensitivity, Delayed / Q000097:blood*; D008614:Meperidine / Q000031:analogs & derivatives*; D009020:Morphine / Q000097:blood*; D010146:Pain / Q000503:physiopathology; D011396:Promedol / Q000097:blood*; D011485:Protein Binding / Q000187:drug effects; D011817:Rabbits; D012684:Sensory Thresholds / Q000187:drug effects
D001798:Blood Proteins; D011396:Promedol; D009020:Morphine; D008614:Meperidine
Vzaimodeĭstvie morfina i promedola s belkami plazmy allergizirovannykh krolikov.