[Synthesis of the fragments A1-8, A1-7, A9-15 and A8-15 of the chicken insulin A chain (author's transl)].
By coupling the peptide derivatives H-Cys(SBut)-Cys(SBut)-His-OMe(6-8 b) and H-Cys(SBut)-Cys(SBut)-OH(6-7b) respectively with Trt-Gly-Ile-Val-Glu(OBut)-Gln-OH(1-5a) the N-terminal sequences A1-8 and A1-7 of the chicken insulin A chain have been prepared. The sequence of A9-15 has been obtained by connecting Bpoc-Asn-Thr(But)-Cys(SBut)-OH (9-11c) and H-Ser(But)-Leu-Try(But)-Gln-OH (12-15). Acylation of the aminopeptidderivative 9-15b with Bpoc-N2H3 yielded fragment A8-15 (8-15).
D000818:Animals; D002645:Chickens; D007202:Indicators and Reagents; D007328:Insulin / Q000138:chemical synthesis*; D046911:Macromolecular Substances; D008722:Methods; D010446:Peptide Fragments / Q000138:chemical synthesis*; D013438:Sulfhydryl Compounds
D007202:Indicators and Reagents; D007328:Insulin; D046911:Macromolecular Substances; D010446:Peptide Fragments; D013438:Sulfhydryl Compounds
Zur Synthese der Hühnerinsulin-A-Kette, I. Darstellung der Fragmente A1-8, A9-15, A1-7 und A8-15.