title: Restoration of the excitability of squid giant axon by tubulin-tyrosine ligase and microtubule proteins.
abstract: Membrane excitability of the squid giant axon was destroyed by perfusing with a medium containing 0.2 mM Ca ions that depolymerize microtubules. Restoration of the membrane excitability was achieved by perfusing the axon with a medium that contained purified tubulin-tyrosine ligase, tubulin, ATP, Mg2+, K+, cyclic AMP, and 300 K Protein.
mesh_terms: D000818:Animals; D001369:Axons / Q000187:drug effects / Q000502:physiology*; D049832:Decapodiformes; D008564:Membrane Potentials / Q000187:drug effects; D008870:Microtubules; D009419:Nerve Tissue Proteins / Q000494:pharmacology*; D010453:Peptide Synthases / Q000494:pharmacology*; D014404:Tubulin; D014443:Tyrosine
chemical_list: D009419:Nerve Tissue Proteins; D014404:Tubulin; D014443:Tyrosine; D010453:Peptide Synthases