The distribution of 75Se-adenosyl selenomethionine in the rat with observations on its potential as a prostate scanning agent.
The preparation of 75Se-adenosyl selenomethionine is described. Following injection into male rats 63% of the administered label was excreted in 24 h, predominantly in the urine. The remaining activity appeared to have joined the S-adenosyl methionine pool residing mainly in the liver and kidney. The maximum incorporation into the ventral prostate was 2 to 4 h after injection at 0.7% injected dose/g wet weight. These results indicate that 75Se-adenosyl selenomethionine is not a suitable radiopharmaceutical for diagnostic scanning of the prostate.
D000818:Animals; D005069:Evaluation Studies as Topic; D007275:Injections, Intravenous; D008297:Male; D008722:Methods; D011467:Prostate / Q000000981:diagnostic imaging*; D011868:Radioisotopes / Q000008:administration & dosage; D011877:Radionuclide Imaging; D051381:Rats; D012436:S-Adenosylmethionine / Q000008:administration & dosage / Q000378:metabolism*; D012643:Selenium / Q000378:metabolism*; D012645:Selenomethionine / Q000008:administration & dosage / Q000378:metabolism*; D013997:Time Factors; D014018:Tissue Distribution
D011868:Radioisotopes; D012436:S-Adenosylmethionine; D012645:Selenomethionine; D012643:Selenium