Coeliactomy: differential toxiphobia conditioning with apomorphine and copper sulfate.
Thirsty coeliac ganglionectomized and sham operated rats consumed more of a novel fluid after a series of presentations, each followed by saline injection, than when apomorphine was injected or copper sulfate intragastrically intubated. Sham rats drank significantly more of this novel solution than ganglionectomized rats following treatments with a very low dose of the peripherally-acting emetic copper sulfate that locally irritates the gastric mucosa. However, sham and ganglionectomized rats drank comparable amounts of the novel fluid following treatments with saline and the two groups drank comparable amounts following treatments with the centrally-acting emetic apomorphine. The results suggest that coeliac ganglionectomy eliminates some, but not all, of the afferent nerves transmitting information concerning visceral toxicosis (produced with intragastric copper sulfate) to the brain.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001362:Avoidance Learning / Q000187:drug effects*; D003300:Copper / Q000494:pharmacology*; D003847:Deoxyglucose / Q000494:pharmacology; D004327:Drinking Behavior / Q000187:drug effects; D005108:Extinction, Psychological / Q000187:drug effects; D005728:Ganglia, Sympathetic / Q000502:physiology*; D008297:Male; D051381:Rats; D012439:Saccharin / Q000494:pharmacology; D013997:Time Factors
D003300:Copper; D003847:Deoxyglucose; D012439:Saccharin; D001058:Apomorphine