[The effect of pentoxifylline on liver perfusion: a comparative study in patients with liver diseases and in normal subjects, using 198Au-colloid-scintigraphy (author's transl)].
Using 198Au-colloid scintigraphy (Anger camera computer-system, 0.3-0.5 mCi radionuclide i.v.) the pattern of liver blood flow, i.e. liver perfusion volume per minute (LPVM), was monitored in 7 patients with liver metastasis (I), 8 patients each with chronic hepatitis (II) and liver cirrhosis (III) and in 10 healthy control subjects (IV). Reading were compared on a within patient basis for the following treatments: baseline control, after a single i.v. injection of 10 ml Trental (= 200 mg pentoxifylline) and after 10 ml physiological saline solution (= placebo). The alteration of LPVM ranged between +0.6 and -3.2% for the comparison baseline/placebo, between +9.7 and +40.8% for baseline/Trental and between +11.5 and +45.4% for placebo/Trental administration. The increase of the elimination constant was statistically significant for all groups and the augmentation of the LPVM for group II, III and IV.
D000328:Adult; D000368:Aged; D002908:Chronic Disease; D005260:Female; D006505:Hepatitis / Q000503:physiopathology; D006801:Humans; D008099:Liver / Q000187:drug effects; D008102:Liver Circulation / Q000187:drug effects*; D008103:Liver Cirrhosis / Q000503:physiopathology; D008107:Liver Diseases / Q000503:physiopathology*; D008113:Liver Neoplasms / Q000503:physiopathology / Q000556:secondary; D008297:Male; D008875:Middle Aged; D010431:Pentoxifylline / Q000494:pharmacology*; D013805:Theobromine / Q000031:analogs & derivatives*
D013805:Theobromine; D010431:Pentoxifylline
Wirkung von Pentoxifyllin auf die Leberdurchblutung. Vergleichsstudie mit 198Au-Kolloid-Szintigraphie bei Leberkranken und -gesunden.