Renal handling of urate: application to the action of tienilic acid.
The renal handling of urate is complex, involving its filtration by glomeruli, partial tubular reabsorption, tubular secretion and also the reabsorption of a portion of the secreted urate. Studies employing tienilic acid, both acutely and chronically, have suggested that this compound exerts its uricosuric action and decreases the plasma urate by inhibiting renal urate reabsorption. The magnitude of the natriuretic and uricosuric actions of tienilic acid are correlated with the concentration of drug in the urine. Crystal equilibration studies have suggested that tienilic acid should not predispose to crystalluria with either uric acid or monosodium urate.
D000818:Animals; D003460:Crystallization; D004285:Dogs; D006016:Glycolates / Q000494:pharmacology*; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D009318:Natriuresis / Q000187:drug effects; D002679:Pan troglodytes; D011718:Pyrazinamide / Q000494:pharmacology; D051381:Rats; D013989:Ticrynafen / Q000494:pharmacology*; D014527:Uric Acid / Q000097:blood / Q000378:metabolism* / Q000652:urine
D006016:Glycolates; D014527:Uric Acid; D011718:Pyrazinamide; D013989:Ticrynafen