title: RNA and protein synthesis in rat brain during exercise. Effect of arginine and some phosphorylated amino acids.
abstract: RNA and protein synthesis is noticeably depressed in the brain of swimming rats. Repeated oral administration of phosphothreonine, phosphoserine or arginine is susceptible of improving brain macromolecular synthesis. A parallel induction is observed on spermine and spermidine accumulation, particularly evident when arginine is used. The anti-fatigue effect of phosphorylated amino acids or arginine may be associated with the observed restoration of brain macromolecular synthesis via polyamine accumulation.
mesh_terms: D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D001120:Arginine / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism* / Q000648:ultrastructure; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D005082:Physical Exertion; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D013095:Spermidine / Q000378:metabolism; D013096:Spermine / Q000378:metabolism; D013347:Subcellular Fractions / Q000378:metabolism; D013550:Swimming; D013997:Time Factors
chemical_list: D000596:Amino Acids; D009419:Nerve Tissue Proteins; D013096:Spermine; D012313:RNA; D001120:Arginine; D013095:Spermidine