Elimination of metabolic cooperation in Chinese hamster cells by a tumor promoter.
Wild-type Chinese hamster V79 cells (6-thioguanine-sensitive) reduce the recovery of 6-thioguanine-resistant cells when they are cultured together at high densities, through a form of  intercellular communication (metabolic cooperation). Cooperation is inhibited by 12-O-tetradecanoyl phorbol-13-acetate, rescuing the 6-thioguanine-resistant cells. These results may be useful in the study of an aspect of the mechanism of tumor promotion and in assaying for promoters.
D000818:Animals; D002450:Cell Communication / Q000187:drug effects*; D002462:Cell Membrane / Q000187:drug effects; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance; D010703:Phorbol Esters / Q000494:pharmacology*; D010704:Phorbols / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D013866:Thioguanine / Q000494:pharmacology
D010703:Phorbol Esters; D010704:Phorbols; D013866:Thioguanine; D013755:Tetradecanoylphorbol Acetate