title: Genetics of hyperuricemia in families with gout.
abstract: Complex segregation analysis supports the polygenic hypothesis of Hauge and Harvald and Neel et al, according to which hyperuricemia ascertained through gout is rarely due to a major gene, evidence for which is not significant in two studies that were considered to favor a major locus.
mesh_terms: D005787:Gene Frequency; D014644:Genetic Variation; D006073:Gout / Q000235:genetics*; D006801:Humans; D008433:Mathematics; D008957:Models, Genetic; D014527:Uric Acid / Q000652:urine*
chemical_list: D014527:Uric Acid