Anticholinergic behavioral effect of phencyclidine.
Phencyclidine (PCP) impaired spatial alternation performance in rats. This effects was mimicked by antimuscarinic anticholinergics (scopolamine, atropine) and PCP derivatives (ketamine, cyclohexamine) but not by a variety of other agents. Muscarinic cholinergic agonists antagonized PCP. Impairment of spatial alteration performance by PCP appears to be mediated, at least in part, by and anticholinergic action; this is the first instance of a behavioral effect of PCP that can be largely attributed to a specific mechanism.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003216:Conditioning, Operant / Q000187:drug effects; D004347:Drug Interactions; D005260:Female; D010276:Parasympatholytics; D010622:Phencyclidine / Q000494:pharmacology*; D051381:Rats; D013028:Space Perception / Q000187:drug effects
D010276:Parasympatholytics; D010622:Phencyclidine