Evaluation of Pseudomonas aeruginosa toxin A in experimental rat burn wound sepsis.
The search for methods to achieve control of Pseudomonas aeruginosa infection continues with the introduction of aluminum-absorbed toxoid developed from P. aeruginosa exotoxin. This toxoid induces significant titers of neutralizing and precipitating antibodies for toxin A when given with appropriate adjuvants. These experiments show that immunization with aluminum phosphate-absorbed toxoid failed to protect burned rats infected with P. aeruginosa. These and previous experiments show that active immunization with live P. aeruginosa provides good strain-specific protection in the same model. No cross-protection was demonstrated between strains of P. aeruginosa in these experiments.
D000818:Animals; D000992:Antitoxins; D001427:Bacterial Toxins / Q000276:immunology*; D002056:Burns / Q000150:complications* / Q000473:pathology; D007114:Immunization; D011552:Pseudomonas Infections / Q000473:pathology / Q000517:prevention & control*; D051381:Rats; D014121:Toxoids
D000992:Antitoxins; D001427:Bacterial Toxins; D014121:Toxoids