Mechanism for the diluent response in asthma.
To investigate the mechanism underlying the airway response to diluent challenge, three adult asthmatic patients who were known to be reactive to inhaled diluent were studied. Airway response as measured by conventional pulmonary function testing was measured under the conditions of time, inhalation of room air, diluent and placebo. Two of the patients responded to time or to room air, suggesting that the response was not due to the phenol-buffered diluent. The third subject reacted primarily to the diluent and not to time, room air or normal saline. Two of the three patients were placebo responders.
D000328:Adult; D000402:Airway Obstruction / Q000209:etiology; D001249:Asthma / Q000175:diagnosis*; D001985:Bronchial Provocation Tests; D006801:Humans; D008297:Male; D008875:Middle Aged; D010919:Placebos; D012129:Respiratory Function Tests; D013997:Time Factors
D010919:Placebos