Resolution of (+/-)-propranolol.
Two improvements in propranolol resolution were developed. Both the (+)- and (-)-di-(p-toluoyl)tartaric acids were used as the resolving agents. This procedure reduced the number of crystallizations needed to obtain a pure product. Furthermore, synthesis of the resolving agent was improved.
D003460:Crystallization; D011433:Propranolol / Q000302:isolation & purification*; D013237:Stereoisomerism
D011433:Propranolol