Plasminogen activator production by human monocytes. I. Enhancement by activated lymphocytes and lymphocyte products.
Human monocytes, but not nylon wool column-nonadherent lymphocytes, produce plasminogen activator. The activity is found only in association with intact cells. Exposure of monocytes to activated lymphocytes or to lymphokine-rich supernatants enhances monocyte plasminogen activator production. The assay allows assessment of baseline and activated human monocyte function.
D000942:Antigens, Bacterial; D002450:Cell Communication; D005342:Fibrinolysis; D006801:Humans; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology; D008222:Lymphokines / Q000494:pharmacology*; D009000:Monocytes / Q000378:metabolism*; D010835:Phytohemagglutinins / Q000494:pharmacology; D010960:Plasminogen Activators / Q000096:biosynthesis*; D013745:Tetanus Toxoid / Q000276:immunology; D014373:Tuberculin / Q000276:immunology
D000942:Antigens, Bacterial; D008222:Lymphokines; D010835:Phytohemagglutinins; D013745:Tetanus Toxoid; D014373:Tuberculin; D010960:Plasminogen Activators