Interactions of (+)-amphetamine and chlorpromazine on neurones in the lower brain stem of the rat.
1 The ability of chlorpromazine to antagonize the effects of iontophoretic application of (+)-amphetamine to single neurones in the medulla and lower pons of anaesthetized rats has been studied. 2 Chlorpromazine, administered systemically or iontophoretically, consistently and specifically antagonized the excitatory actions of (+)-amphetamine, but not those of noradrenaline on the same neurone. 3 It is concluded that chlorpromazine reduces the effect of (+)-amphetamine by a presynaptic mechanism. 4 (+)-Amphetamine did not mimic the prolonged inhibitory response of some neurones to noradrenaline but often excited these neurones and chlorpromazine blocked these excitatory responses to (+)-amphetamine.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001933:Brain Stem / Q000187:drug effects*; D002746:Chlorpromazine / Q000494:pharmacology*; D003913:Dextroamphetamine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004298:Dopamine / Q000502:physiology; D004347:Drug Interactions; D008297:Male; D009474:Neurons / Q000187:drug effects*; D051381:Rats; D013997:Time Factors
D000109:Acetylcholine; D003913:Dextroamphetamine; D002746:Chlorpromazine; D004298:Dopamine