Effect of pancreatic kallikrein, sperm acrosin and high molecular weight (HMW) kininogen on cervical mucus penetration ability of seminal plasma-free human spermatozoa.
Bradykinin is able to stimulate sperm migration of SPFS; HMW kininogen does not effect sperm migration of SPFS; Kallikrein and acrosin induce small stimulation of sperm migration of SPFS indicating traces of kininogen attached to the sperm surface enabling liberation of kinins; In the presence of kininogen, kallikrein and acrosin significantly improve cervical mucus penetration of SPFS; Lastly, from the presented studies there is experimental evidence that acrosin is involved in stimulation of sperm migration within the female genital tract due to liberation of kinins from kininogen (see Figure 7.).
D000176:Acrosin / Q000494:pharmacology*; D000818:Animals; D002582:Cervix Mucus / Q000187:drug effects / Q000502:physiology*; D010450:Endopeptidases / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007610:Kallikreins / Q000494:pharmacology*; D007700:Kinetics; D007704:Kininogens / Q000494:pharmacology*; D008297:Male; D010179:Pancreas / Q000201:enzymology*; D012661:Semen / Q000502:physiology; D013081:Sperm Motility; D013094:Spermatozoa / Q000187:drug effects / Q000201:enzymology* / Q000502:physiology*; D013552:Swine
D007704:Kininogens; D010450:Endopeptidases; D007610:Kallikreins; D000176:Acrosin