Doxorubicin 14-ethers.
The synthesis and the antitumor activities of a group of doxorubicin (adriamycin) 14-ethers are reported. The new compounds were found to have an activity similar to that of daunorubicin, at somewhat higher doses, but inferior to that of doxorubicin.
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D004317:Doxorubicin / Q000138:chemical synthesis* / Q000627:therapeutic use; D004987:Ethers / Q000138:chemical synthesis; D007941:Leukemia P388 / Q000188:drug therapy*; D007942:Leukemia, Experimental / Q000188:drug therapy*; D051379:Mice
D000970:Antineoplastic Agents; D004987:Ethers; D004317:Doxorubicin