The effect of combined administration of L-proline and glycine on GH and IRI release in healthy prepuberal children.
Proline (100 mg/kg b.w.) was given per os and after 30 minutes 10% glycine was i.v. injected to 25 healthy children of both sexes. A positive response (an increase of over 5 ng/ml of serum level of GH) was found in 21 of the 25 children. The insulin test showed a positive response in 24 of the 25 children. It was concluded that the decrease in glycine dosage from 250 mg/kg b.w. (earlier reports by the same authors) to 100 mg/kg b.w. (present data) is generally compensated by l-proline priming. The IRI serum levels were almost unchanged. By l-proline priming, the glycine test can also be applied to subjects with body weight over 40 kg, in doses of 100 mg/kg b.w. for exploring the secretory reserve of the somatotropic axis.
D000596:Amino Acids / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D002648:Child; D005260:Female; D005998:Glycine; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000097:blood*; D007700:Kinetics; D008297:Male; D011392:Proline / Q000097:blood; D011627:Puberty
D000596:Amino Acids; D001786:Blood Glucose; D007328:Insulin; D013006:Growth Hormone; D011392:Proline; D005998:Glycine