Relationship between bacterial binding to lymphocytes and clinical features in chronic lymphocytic leukemia.
In previous studies we showed that spontaneous bacterial adherence can be used to identify human lymphocyte subpopulations and to demonstrate variable binding patterns in chronic lymphocytic leukemia (CLL). In this study, 10 strains of bacteria of different genera and species were used in blood smears from 24 CLL patients to determine the percentages of lymphocytes that bind bacteria. From these percentages, binding indices were calculated. The symptoms and other laboratory tests were independently recorded and the stages determined. When the two sets of data were compared, relatively low binding indices were found in symptomatic patients or in Stages III and IV; relatively high binding indices were found in asymptomatic patients or in Stages I and II. We suggest that with progression of leukemia, lymphocytes with less "lectin" recognition potential are selected and escape any control mechanism of proliferation.
D000368:Aged; D001419:Bacteria / Q000276:immunology*; D006801:Humans; D007104:Immune Adherence Reaction; D007136:Immunoglobulins; D007945:Leukemia, Lymphoid / Q000145:classification / Q000175:diagnosis / Q000276:immunology*; D008214:Lymphocytes / Q000145:classification / Q000276:immunology*; D008875:Middle Aged
D007136:Immunoglobulins