title: [Cardiovascular effect of 1,2,4-benzothiadiazine-1,1-dioxide derivatives. VIII].
abstract: A series of carboxy- and carbomethoxyalkyl derivatives of 3-amino-1,2,4-benzothiaidazin-1,1-dioxide either substituted or unsubstituted in the benzene ring [compounds (I leads to XVIII)] was prepared and tested for cardiovascular activity. It was found that the introduction of a carboxy-or carbalkoxy-group in the omega position of 3-alkylamino derivatives of 1,2,4-benzothiadiazine-1,1-dioxide usually causes marked decrease or abolition of the cardiovascular activity shown by the parent compounds. The negative effect on the pressor trace (hypotension and increase in differential pressure) is more frequent and significant than that on bradycardial activity.
mesh_terms: D000818:Animals; D001581:Benzothiadiazines / Q000138:chemical synthesis* / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D002317:Cardiovascular Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002319:Cardiovascular System / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D051381:Rats
chemical_list: D001581:Benzothiadiazines; D002317:Cardiovascular Agents
vernacular_title: Azione cardiovascolare di derivati dell'1,2,4-benzotiadiazin-1,1-diossido nota VIII.