[Possible role of DNAse I in the development of experimental leukemia].
An increase in the DNAase 1 activity in the serum and an increase in the DNAase inhibitor activity in the spleen in the development of virus Friend leukemia were demonstrated. Increased activity of the inhibitor in the spleen was also revealed after intravenous injection of exogenous DNAase 1 into mice. A potential role of serum DNAase 1 in the development of experimental leukemia is discussed.
D000818:Animals; D002417:Cattle; D003851:Deoxyribonucleases / Q000037:antagonists & inhibitors / Q000097:blood*; D004791:Enzyme Inhibitors / Q000096:biosynthesis; D005622:Friend murine leukemia virus; D007942:Leukemia, Experimental / Q000209:etiology*; D008297:Male; D051379:Mice; D013154:Spleen / Q000201:enzymology
D004791:Enzyme Inhibitors; D003851:Deoxyribonucleases
O vozmozhnoĭ roli DNK-azy I v razvitii éksperimental'nogo leĭkoza.