Cytidine-5'-diphospho-choline conjugates. II.--Immunogenicity in rats.
Cytidine diphospho-choline (CDPC) derivatives of human serum albumin (HSA) are immunogenic in the rat when injected in adjuvants. They induce a very rapid synthesis of IgM anti-phosphorylcholine antibodies which was followed by the synthesis of anti-CDPC antibodies and of anti-HSA antibodies. The activated nucleotide was able to induce specific skin sensitivity in rats after one skin painting. Gastric intubations of rats with low doses of HSA conjugates 8 days before an infection with the nematode Nippostrongylus brasiliensis were followed by a reduction of the resulting intestinal worm burden.
D000818:Animals; D000917:Antibody Formation; D000918:Antibody Specificity; D000941:Antigens; D002794:Choline / Q000031:analogs & derivatives*; D003566:Cytidine Diphosphate Choline / Q000276:immunology* / Q000494:pharmacology; D006801:Humans; D007422:Intestines / Q000469:parasitology; D009559:Nippostrongylus / Q000276:immunology / Q000302:isolation & purification; D051381:Rats; D012709:Serum Albumin / Q000276:immunology* / Q000494:pharmacology; D012867:Skin / Q000187:drug effects
D000941:Antigens; D012709:Serum Albumin; D003566:Cytidine Diphosphate Choline; D002794:Choline