The effects of ions on the binding of agonists and antagonists to muscarinic receptors.
1 There are no selective effects of Na+, K+, Ca2+, Mg2+ or Cl- on the binding of antagonists or agonists to muscarinic receptors in rat brain. A decrease in affinity related to ionic strength is found for all these ions. 2 Larger effects were produced by T1+, La3+, and some transition metal ions.
D000818:Animals; D001921:Brain / Q000378:metabolism; D002217:Carbachol / Q000378:metabolism; D002794:Choline / Q000031:analogs & derivatives / Q000378:metabolism; D007477:Ions / Q000494:pharmacology*; D010276:Parasympatholytics / Q000378:metabolism*; D010277:Parasympathomimetics / Q000378:metabolism*; D011189:Potassium Chloride / Q000494:pharmacology; D051381:Rats; D011950:Receptors, Cholinergic / Q000378:metabolism*; D011976:Receptors, Muscarinic / Q000378:metabolism*; D012601:Scopolamine / Q000378:metabolism; D012965:Sodium Chloride / Q000494:pharmacology
D007477:Ions; D010276:Parasympatholytics; D010277:Parasympathomimetics; D011950:Receptors, Cholinergic; D011976:Receptors, Muscarinic; D012965:Sodium Chloride; D011189:Potassium Chloride; D002217:Carbachol; D012601:Scopolamine; D002794:Choline