title: Short- and long-term effects of hypophysectomy and unilateral ovariectomy on ovarian follicular populations in sheep.
abstract: The effects of hypophysectomy and unilateral ovariectomy on the total number of follicles with greater than 3 layers of granulosa cells were determined at 4 and 70 days following treatment. The population of preantral follicles (less than 0.23 min diam.) was found to be under the control of gonadotrophins but such control was only evident on a long-term basis. At 70 days after unilateral ovariectomy there was a large increase in the number of preantral follicles but at 70 days after hypophysectomy there was a large decrease. The population of antral follicles (greater than 0.23 mm diam.) was under the immediate control of gonadotrophins. By 4 days after hypophysectomy all large antral follicles had become atretic and the number of antral follicles was further decreased at 70 days after treatment. At 70 days after unilateral ovariectomy there was an increase in the number of antral follicles. The follicular growth rates at 70 days following treatment were decreased in hypophysectomized ewes but increased in ewes after unilateral ovariectomy.
mesh_terms: D000818:Animals; D002369:Castration; D005260:Female; D006107:Granulosa Cells / Q000166:cytology; D007016:Hypophysectomy; D008940:Mitotic Index; D009866:Oogenesis; D006080:Ovarian Follicle / Q000502:physiology*; D010908:Pituitary Hormones, Anterior / Q000502:physiology; D012756:Sheep
chemical_list: D010908:Pituitary Hormones, Anterior