title: Nerve sheaths and motoneurone collateral sprouting.
abstract: When disease or injury causes partial loss of innervation from a muscle, the remaining axons sprout and form new connections to the denervated muscle fibres. Sprouting can occur in two ways: from axon terminals (terminal sprouting) or from the intramuscular axons themselves, probably from the nodes of Ranvier (collateral sprouting). Terminal sprouting has been induced experimentally using various methods, including partial denervation, nerve conduction block and nerve transmission block. A common factor in the induction of terminal sprouting seems to be changes in the surface membrane of muscle fibres; these changes and terminal sprouting are prevented by direct stimulation of the muscle. Collateral sprouting has been induced only by partial denervation and is not prevented by direct stimulation. This has been taken as evidence for an earlier suggestion that products of nerve or axon degeneration may be a direct stimulus for collateral sprouting. We report here that axon degeneration products alone are probably not the stimulus for collateral sprouting.
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D001369:Axons / Q000502:physiology; D051379:Mice; D009046:Motor Neurons / Q000201:enzymology / Q000502:physiology*; D009121:Muscle Denervation; D009410:Nerve Degeneration; D009416:Nerve Regeneration; D005082:Physical Exertion; D011901:Ranvier's Nodes / Q000502:physiology
chemical_list: D000110:Acetylcholinesterase