Stability-indicating assay of acetaminophen in an effervescent tablet by ion-pair high-performance liquid chromatography.
A stability-indicating analytical method is described for determining acetaminophen and its degradation product, p-aminophenol, in an affervescent tablet. Tablets assayed by ion-pair high-performance reversed-phase liquid partition chromatography required no sample cleanup. The method applied to tablets containing 325 mg of acetaminophen yielded an average recovery of 99.6% with a relative standard deviation of 0.70% (n = 10). As little as 0.005% p-aminophenol could be detected.
D000082:Acetaminophen / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D008722:Methods; D013607:Tablets
D013607:Tablets; D000082:Acetaminophen