The mechanism of the localization of 67gallium citrate in experimental abscesses.
67Ga accumulation in turpentine-induced abscesses, from 5 h to 20 days old, in the rat has been investigated, and the results indicate that this is dependent on polymorphonuclear leukocyte (PMN) infiltration of the inflamed site. 67Ga concentration 24 h after injection correlates well with the activities of the lysosomal enzymes, aryl sulphatase and beta-glucuronidase, P less than 0.001, and with the DNA content of the tissue. There is no direct relationship with the rate of DNA synthesis. The mechanism of lysosomal incorporation into PMNs is consistent with the factors involved in 67Ga uptake into tumours and normal tissues.
D000038:Abscess / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000201:enzymology; D000818:Animals; D001192:Arylsulfatases / Q000378:metabolism; D002951:Citrates / Q000378:metabolism*; D004247:DNA / Q000096:biosynthesis; D005710:Gallium Radioisotopes / Q000378:metabolism*; D005966:Glucuronidase / Q000378:metabolism; D008247:Lysosomes / Q000201:enzymology; D008297:Male; D009504:Neutrophils / Q000201:enzymology; D011877:Radionuclide Imaging; D051381:Rats; D014425:Turpentine
D002951:Citrates; D005710:Gallium Radioisotopes; D004247:DNA; D001192:Arylsulfatases; D005966:Glucuronidase; D014425:Turpentine