Influence of adrenalectomy and sex on the binding of 3-methylcholanthrene to cytosol macromolecules of rat liver.
The retention of 3-methylcholanthrene (3-MC) in rat hepatic cytosol was significantly enhanced by adrenalectomy. In contrast, there was no significant difference in 3-MC retention in females as compared with males. 3-MC present in the cytosol fraction was bound to macromolecules and could be separated into three fractions by ion-exchange column chromatography.
D000315:Adrenalectomy; D000818:Animals; D003600:Cytosol / Q000378:metabolism; D005260:Female; D008099:Liver / Q000378:metabolism* / Q000648:ultrastructure; D008297:Male; D008748:Methylcholanthrene / Q000378:metabolism*; D011485:Protein Binding; D051381:Rats; D012737:Sex Factors; D013997:Time Factors
D008748:Methylcholanthrene