title: [Antimutagenic effect of alpha-tocopherol on the gene mutation frequency in Salmonella].
abstract: The work presents the data on the antimutagenic effect of alpha-tocopherol on the frequency of N-nitroso-N-methyl urea induced gene mutations in Salmonella in vitro and in vivo. In vitro tests have revealed the dependence of decreasing the rate of induced mutations both on combination of treatments with mutagen/antimutagen and on the dose of the mutagen. In vivo tests have demonstrated that the mutagenic effect of alpha-tocopherol depends on the duration of its action on organisms.
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005787:Gene Frequency / Q000187:drug effects*; D066298:In Vitro Techniques; D008770:Methylnitrosourea / Q000037:antagonists & inhibitors*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009154:Mutation; D009607:Nitrosourea Compounds / Q000037:antagonists & inhibitors*; D012475:Salmonella / Q000187:drug effects* / Q000235:genetics; D014810:Vitamin E / Q000235:genetics*
chemical_list: D009607:Nitrosourea Compounds; D014810:Vitamin E; D008770:Methylnitrosourea
vernacular_title: Antimutagennyĭ éffekt al'fa-tokoferola na chastotu gennykh mutatsiĭ u Salmonella.