Biochemical abnormalities of the human diabetic glomerular basement membrane.
Since the biochemical composition of the diabetic glomerular basement membrane is still a controversial area, a study was carried out using kidneys from seven diabetic and seven nondiabetic subjects. In diabetic membranes, the glycine, hydroxylysine, glucose, galactose, and hydroxylysine-linked disaccharide unit content was increased together with a decrease in the half-cystine and sialic acid content. These findings support the view of a biochemical alteration in the human diabetic glomerular basement membrane.
D000328:Adult; D000368:Aged; D000596:Amino Acids / Q000378:metabolism*; D001485:Basement Membrane / Q000378:metabolism; D050260:Carbohydrate Metabolism; D003553:Cystine / Q000378:metabolism; D003920:Diabetes Mellitus / Q000503:physiopathology*; D005260:Female; D005944:Glucosamine / Q000378:metabolism; D006801:Humans; D006901:Hydroxylysine / Q000378:metabolism; D007678:Kidney Glomerulus / Q000378:metabolism*; D008239:Lysine / Q000378:metabolism; D008297:Male; D008875:Middle Aged
D000596:Amino Acids; D006901:Hydroxylysine; D003553:Cystine; D008239:Lysine; D005944:Glucosamine