Suggestions for monitoring patients during treatment with aminoglycoside antibiotics.
Guidelines are suggested for the surveillance and prevention of ototoxicity in adults, based on experience and a compilation of opinions from otolaryngologists and infectious disease specialists. The influence of dosage and renal function on serum levels and their relevance to ototoxicity are discussed. Indications for testing of inner ear function are considered.
D000583:Amikacin / Q000009:adverse effects; D000617:Aminoglycosides / Q000009:adverse effects* / Q000097:blood; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000097:blood; D001299:Audiometry; D007758:Ear, Inner / Q000187:drug effects* / Q000502:physiology; D005839:Gentamicins / Q000009:adverse effects; D006801:Humans; D007612:Kanamycin / Q000009:adverse effects; D007668:Kidney / Q000187:drug effects / Q000502:physiology; D007674:Kidney Diseases / Q000503:physiopathology; D008991:Monitoring, Physiologic; D009355:Neomycin / Q000009:adverse effects; D013307:Streptomycin / Q000009:adverse effects; D014031:Tobramycin / Q000009:adverse effects
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D005839:Gentamicins; D007612:Kanamycin; D000583:Amikacin; D009355:Neomycin; D014031:Tobramycin; D013307:Streptomycin