[Effect of the alkaloid lappaconitine on ion currents through the somatic membrane of Helix pomatia neurons].
The effect of alkoloid lappaconitine on ionic currents through the somatic membrane of identified neurons of the mollusc Helix pomatia was studied under voltage-clamp conditions. It is shown that 4 mM lappaconitine causes a reversible blocking action on the calcium channels. Concentration exceeding 4 mM causes irreversible changes. Lappaconitine had either an insignificant or no effect on sodium currents.
D000157:Aconitine / Q000031:analogs & derivatives* / Q000494:pharmacology; D031841:Aconitum / Q000031:analogs & derivatives*; D000818:Animals; D005724:Ganglia / Q000166:cytology; D006372:Helix, Snails; D007473:Ion Channels / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects*
D007473:Ion Channels; D000157:Aconitine; C022150:lappaconitine
Vliianie alkaloida lappakonitina na ionnye toki cherez somaticheskuiu membranu neĭronov Helix pomatia.