Cochlear toxicity of butikacin (UK-18,892), a new semisynthetic aminoglycoside antibiotic, in guinea pigs.
The cochleotoxic potential of butikacin (UK-18,892), a new semisynthetic aminoglycoside, has been evaluated in neonatal guinea pigs in comparison with amikacin, gentamicin, and kanamycin A. All compounds produced a dose-related increase of the mean threshold sound intensity required to elicit Preyer's reflex. Butikacin produced a similar level of cochlear toxicity to that of kanamycin A, but tended to be less cochleotoxic than amikacin. Gentamicin was the least cochleotoxic.
D000583:Amikacin / Q000031:analogs & derivatives* / Q000633:toxicity; D000818:Animals; D001309:Auditory Threshold / Q000187:drug effects; D003051:Cochlea / Q000187:drug effects*; D005260:Female; D006168:Guinea Pigs; D006311:Hearing Disorders / Q000139:chemically induced; D007612:Kanamycin / Q000031:analogs & derivatives*; D007759:Labyrinth Diseases / Q000139:chemically induced; D008297:Male; D013997:Time Factors
D007612:Kanamycin; D000583:Amikacin; C016924:butikacin