On the mechanism of central effect of thyroxine on body temperature in dogs.
The effect of intraventricular injection of thyroxine 1 microgram/animal on body temperature was studied in dogs under resting conditions: at normal ambient temperature, at high ambient temperature (35 degrees C) and during administration of pyrogen. Besides, changes in body temperature were elucidated in dogs performing physical exercise following I.V. T4 injection in the same dose. Thyroxine exerted its central action on body temperature only in dogs performing physical exercise.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D004285:Dogs; D006358:Hot Temperature; D007276:Injections, Intraventricular; D008297:Male; D005082:Physical Exertion; D011749:Pyrogens / Q000494:pharmacology; D013974:Thyroxine / Q000008:administration & dosage* / Q000494:pharmacology
D011749:Pyrogens; D013974:Thyroxine