The action of histamine, histamine H1-and H2-receptor agonists on noradrenaline level in rat brain.
Intraventricularly administered histamine (HI) (20--1000 micrograms) decreased noradrenaline (NA) .level in rat hypothalamus. 4-Methyl-HI (4-MeHI), but not 2-pyridylethylamine (2-PEA), reproduced the action of HI. Neither HI, nor 4-MeHI induced depression of hypothalamic NA content was antagonized by HI H2-receptor antagonists, cimetidine or metiamide. Chloropyramine reversed the NA-depleting action of HI.
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D002927:Cimetidine / Q000494:pharmacology; D005260:Female; D006632:Histamine / Q000031:analogs & derivatives / Q000494:pharmacology*; D007031:Hypothalamus / Q000378:metabolism; D008785:Metiamide / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D011968:Receptors, Histamine / Q000187:drug effects*; D011969:Receptors, Histamine H1 / Q000187:drug effects*; D011970:Receptors, Histamine H2 / Q000187:drug effects*; D013997:Time Factors
D011968:Receptors, Histamine; D011969:Receptors, Histamine H1; D011970:Receptors, Histamine H2; D008785:Metiamide; D002927:Cimetidine; D006632:Histamine; D009638:Norepinephrine