Comparative study in angiocardiography in children, evaluating the side-effects of non-ionic and ionic contrast media.
The study concerns 127 consecutive patients, presenting congenital heart disease, with an age distribution from neonatal to 15 years (mean 5 years). With non-ionic Amipaque, 164 injections were performed, with ionic Isopaque Coronar 81. Isopaque Coronar caused in 51% of the cases a clear discomfort for the patient; with Amipaque the side-effects were reduced to 9% (p less than 0.001). The mean body temperature rise with Amipaque was only 0.09 degrees C, against 0.28 degrees C with Isopaque Coronar (p less than 0.001). The changes in the heart rate reached 8.35% with Amipaque and 15.2% with Isopaque Coronar (p less than 0.001). Amipaque caused a mean of 1.8 extrasystoles per injection; Isopaque Coronar 2.2 (p less than 0.05). The quality of the angiogram with Amipaque was quite better than with Isopaque Coronar (p less than 0.0025). The non-ionic Amipaque is a much safer and better tolerated compound that the ionic Isopaque Coronar for paediatric angiocardiography.
D000293:Adolescent; D000790:Angiocardiography; D001775:Blood Circulation / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D004338:Drug Combinations; D006330:Heart Defects, Congenital / Q000000981:diagnostic imaging; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007463:Iodobenzoates / Q000009:adverse effects*; D008536:Meglumine / Q000009:adverse effects / Q000031:analogs & derivatives; D008793:Metrizamide / Q000009:adverse effects*; D008794:Metrizoic Acid / Q000009:adverse effects* / Q000031:analogs & derivatives; D011652:Pulmonary Circulation / Q000187:drug effects
D004338:Drug Combinations; D007463:Iodobenzoates; D008536:Meglumine; D008794:Metrizoic Acid; D008793:Metrizamide; C021342:methylglucamine metrizoate