title: [Cancerostatically active 6,6a,7,8,13,13a-hexahydro-1-benzopyrano[4,3-b]-1,5-benzodiazepine diastereoisomers (author's transl)].
abstract: The action of many psychotropic drugs on the adenylate cyclase system and its role in the regulation of tumour cell division justify the expectance that potentially psychotropic 1-benzopyrano[4,3-b]-1,5-benzodiazepine derivatives (3a,b and 6a,b) will also exert a cancerostatic effect. The synthesis of 6,6a,7,8,13,13a-hexahydro-1-benzopyrano[4,3-b]-1,5-benzodiazepines (4a and b) and their separation into the antileukaemic (L 1210) cis-forms and the inefficacious trans-forms are described. The cis-form 5a, unlike the trans-form 6a, stimulated the adenylate cyclase system.
mesh_terms: D000067956:Adenylyl Cyclase Inhibitors; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D001569:Benzodiazepines / Q000138:chemical synthesis* / Q000494:pharmacology; D007939:Leukemia L1210 / Q000188:drug therapy; D007941:Leukemia P388 / Q000188:drug therapy; D051381:Rats; D013237:Stereoisomerism
chemical_list: D000067956:Adenylyl Cyclase Inhibitors; D000970:Antineoplastic Agents; D001569:Benzodiazepines
vernacular_title: Cancerostatisch wirksame 6,6a,7,8,13,13a-Hexahydro-1-benzopyrano[4,3-b]-1,5-benzodiazepin-Diastereoisomere.