[Generalized ceroid histiocytosis in type 5 hyperlipoproteinaemia (author's transl)].
Histochemical, fluorescence and electron microscopic features of histiocytes from the spleen, lymph nodes and liver were investigated in a patient with type 5 hyperlipoproteinaemia with splenomegaly (Fredrickson and Lees, 1965). The pigment stored in histocytes represented ceroid, a product of oxidation and polymerization of unsaturated lipids. The morphological features of ceroid and histogenesis of ceroid histiocytosis are discussed.
D000328:Adult; D002566:Ceroid / Q000032:analysis*; D006529:Hepatomegaly / Q000209:etiology; D006644:Histiocytes / Q000032:analysis; D006801:Humans; D006954:Hyperlipoproteinemia Type V / Q000150:complications; D008099:Liver / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008206:Lymphatic Diseases / Q000209:etiology*; D008297:Male; D010860:Pigments, Biological / Q000032:analysis*; D013154:Spleen / Q000473:pathology / Q000648:ultrastructure; D013163:Splenomegaly / Q000209:etiology
D002566:Ceroid; D010860:Pigments, Biological
Generalisierte Ceroidhistiozytose bei Hyperlipoproteinämie, Typ 5, nach Fredrickson.