Enhancement of interferon antitumor action by sodium butyrate.
Sodium butyrate together with interferon enhances the antitumor effect of interferon in vivo. When Sarcoma 180 TG cells are inoculated in mice, the mean survival time and final survival rate are greatly increased compared to those for treatment with interferon alone. Similarly, a significant delay in the mean survival time is observed when mice inoculated with L1210 cells are treated with sodium butyrate and interferon. This effect could be due at least in part to a potentiation of interferon action on the tumor cells.
D000818:Animals; D002087:Butyrates / Q000008:administration & dosage*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004357:Drug Synergism; D007372:Interferons / Q000008:administration & dosage*; D007939:Leukemia L1210 / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D012510:Sarcoma 180 / Q000188:drug therapy*; D013997:Time Factors
D002087:Butyrates; D007372:Interferons