title: The role of gastric lipolysis on fat absorption and bile acid metabolism in the rat.
abstract: In vivo studies were carried out in young Sprague-Dawley rats to examine the role of gastric lipolysis on fat absorption and bile acid metabolism. When fed by gastric perfusion 5 times (corn oil, 4 g/day) their usual dietary intake of fat, rats deprived of lingual lipase by the creation of an esophageal fistula had a significant degree of fat and bile acid malabsorption as well as a shortened bile acid half-life when compared to animals with a gastrostomy. The % fat absorption, bile acid loss and bile acid pool were normal in 2 groups of esophageal fistula rats fed the same quantity of corn oil or twice (8 g/day) that amount as a fine emulsion. In view of a negligible gastric lipase activity in animals with an esophageal fistula and of decreased hydrolysis of a triglyceride test meal, these data suggest that gastric lipolysis is of physiological importance in situations where lipolytic mechanisms are stressed by a large fat intkae. Its principal role is to potentiate intestinal lipolysis by facilitating the emulsification of dietary lipids through its formed products and, therefore, the contact of pancreatic lipase with its substrates.
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism*; D004041:Dietary Fats; D004764:Enterohepatic Circulation; D005753:Gastric Mucosa / Q000378:metabolism*; D006207:Half-Life; D007408:Intestinal Absorption; D007700:Kinetics; D008049:Lipase / Q000378:metabolism; D050356:Lipid Metabolism; D008053:Lipid Mobilization; D008297:Male; D051381:Rats
chemical_list: D001647:Bile Acids and Salts; D004041:Dietary Fats; D008049:Lipase