Subtypes of depression identified by the KDS-3A: a pilot study.
To devise a system of classifying depression subtypes at intake, the authors administered the Kupfer Detre Scale (KDS-3A) to depressed outpatients at intake and after one, three, and six months of treatment with tricyclic antidepressants or lithium carbonate. None of the 10 tricyclic responders scored below 8 on the 14-point chronic anxiety scale at intake while 7 of the 12 lithium responders did, suggesting that any patient scoring below 8 is a probable candidate for lithium therapy. Patients scoring 8 or above on the chronic anxiety scale fell into two categories, those who had a low impulisivity score and responded to tricyclic antidepressants and those who had a high impulsivity score, responded to lithium, and had cyclothymic disorder or emotionally unstable character disorder.
D000328:Adult; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use; D001007:Anxiety / Q000175:diagnosis / Q000188:drug therapy; D001714:Bipolar Disorder / Q000175:diagnosis* / Q000188:drug therapy; D002908:Chronic Disease; D003863:Depression / Q000175:diagnosis* / Q000188:drug therapy; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008094:Lithium / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales
D000929:Antidepressive Agents, Tricyclic; D008094:Lithium