Effect of lisuride on inhibition of lactation and serum prolactin.
Lisuride, a new semisynthetic ergot derivative, was given to 53 women to inhibit lactation; 26 women had 300 micrograms daily and 27 had 600 micrograms daily for seven days. Eight lactating women acted as controls. Lisuride effectively inhibited lactation and also suppressed the serum prolactin levels; the latter effect was dose related. Lisuride produced no untoward side effects.
D055598:Chemical Phenomena; D002621:Chemistry; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004873:Ergolines / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007774:Lactation / Q000187:drug effects*; D008090:Lisuride / Q000494:pharmacology*; D011247:Pregnancy; D011388:Prolactin / Q000097:blood*
D004873:Ergolines; D011388:Prolactin; D008090:Lisuride