Concanavalin A stimulation of plasminogen activator production in pig kidney cells in culture.
Addition of subtoxic doses of the lectin concanavalin A to growing subconfluent monolayer cultures of pig kidney cells causes an increase in extra- and intracellular plasminogen activator activity which is reversibly inhibited by actinomycin D, cycloheximide and alpha-methyl-D-mannoside. These results suggest that cell surface events may play an important modulatory role in plasminogen activator production.
D000818:Animals; D002462:Cell Membrane; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology*; D003513:Cycloheximide / Q000494:pharmacology; D003609:Dactinomycin / Q000494:pharmacology; D007668:Kidney / Q000378:metabolism*; D008362:Mannosides; D008766:Methylmannosides / Q000494:pharmacology; D010960:Plasminogen Activators / Q000096:biosynthesis*; D013552:Swine
D008362:Mannosides; D008766:Methylmannosides; D003208:Concanavalin A; D003609:Dactinomycin; D003513:Cycloheximide; D010960:Plasminogen Activators