title: Immunologic similarities between the hypothalamic alpha-bungarotoxin receptor and the Torpedo californica nicotinic cholinergic receptor.
abstract: The solubilized rat central nervous system (hypothalamic) nicotinic cholinergic receptor and the Torpedo nicotinic cholinergic receptors are immunologically similar and show greater than 60% immunologic cross-reactivity using a double-antibody technique. Antibodies to the Electrophorus and Torpedo receptors also decrease the rate of alpha-bungarotoxin binding to these membraneous receptors. It is concluded that the Torpedo and hypothalamic nicotinic receptors are immunologically similar and that receptor binding sites for alpha-bungarotoxin and antibodies are physically close. These studies indicate that alpha-bungarotoxin can be used to study the nicotinic cholinergic receptor of the rat hypothalamus.
mesh_terms: D000818:Animals; D000906:Antibodies / Q000032:analysis; D002038:Bungarotoxins / Q000378:metabolism*; D003429:Cross Reactions; D005260:Female; D005399:Fishes; D007031:Hypothalamus / Q000276:immunology*; D051381:Rats; D011950:Receptors, Cholinergic / Q000276:immunology*; D011978:Receptors, Nicotinic / Q000276:immunology*; D013574:Synaptosomes / Q000276:immunology
chemical_list: D000906:Antibodies; D002038:Bungarotoxins; D011950:Receptors, Cholinergic; D011978:Receptors, Nicotinic