Calcium and magnesium binding by parvalbumin. A proton magnetic resonance spectral study.
Proton magnetic resonance spectroscopy has been used to monitor the kinetics and nature of the conformational transitions induced by binding of calcium and magnesium to carp parvalbumin. Rate constants have been determined for the exchange between the cation dependent conformational states of the protein in solution. These data enable a description of the kinetics and mechanism controlling the calcium flux in vivo during contraction.
D000818:Animals; D001665:Binding Sites; D002118:Calcium / Q000378:metabolism*; D002347:Carps; D007700:Kinetics; D008274:Magnesium / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D009119:Muscle Contraction; D009124:Muscle Proteins; D010320:Parvalbumins; D011485:Protein Binding; D011487:Protein Conformation
D009124:Muscle Proteins; D010320:Parvalbumins; D008274:Magnesium; D002118:Calcium