Effects of somatic treatments on mood in endogenous depression.
The effects of ECT, amitriptyline, clomipramine, maprotiline and desipramine on the course of endogenous depression were compared in 105 patients using repeated self-administered mood questionnaires as the outcome measure. Remission was more rapid after ECT therapy than psychopharmacological treatment, but the absolute improvement did not differ significantly between ECT and other somatic therapies. Improvement in response to clomipramine was more rapid than to other psychopharmacological agents, and did not differ from that in response to ECT. The advantages and disadvantages of ECT for endogenous depression are discussed.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000639:Amitriptyline / Q000627:therapeutic use; D000928:Antidepressive Agents / Q000627:therapeutic use*; D002997:Clomipramine / Q000627:therapeutic use; D003863:Depression / Q000188:drug therapy / Q000628:therapy*; D003891:Desipramine / Q000627:therapeutic use; D004565:Electroconvulsive Therapy; D004644:Emotions; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008297:Male; D008376:Maprotiline / Q000627:therapeutic use; D008875:Middle Aged; D011581:Psychological Tests; D013997:Time Factors
D000928:Antidepressive Agents; D000639:Amitriptyline; D008376:Maprotiline; D002997:Clomipramine; D003891:Desipramine