A simple method for incorporating single pass dialysate delivery and controlled ultrafiltration with the RP-6 high flux dialyzer.
A simple hemodialysis protocol has been developed to permit significant "middle molecule" clearance, yet retain normal low molecular weight clearance. The high flux RP-6 dialyzer has been combined with a single pass dialysate delivery system to provide accurate control of ultrafiltration without resorting to specialized or expensive equipment. By operating the RP-6 in the co-current mode, a simple valve on the dialysate output can be used to regulate ultrafiltration. At QB = 200 ml/min and QD = 500 ml/min, CU = 127 ml/min and CB12 = 56 ml/min at zero ultrafiltration rate; these values increase considerably with ultrafiltration. This protocol offers dialysis centers with standard equipment the opportunity to use high flux membranes in a routine manner.
D000818:Animals; D001783:Blood Flow Velocity; D001786:Blood Glucose; D001794:Blood Pressure; D001806:Blood Urea Nitrogen; D004285:Dogs; D008566:Membranes; D008970:Molecular Weight; D006435:Renal Dialysis / Q000379:methods*; D014462:Ultrafiltration / Q000379:methods; D014805:Vitamin B 12 / Q000097:blood
D001786:Blood Glucose; D014805:Vitamin B 12