title: [Acanthosis nigricans, hirsutism and insulin-resistant diabetes].
abstract: Three girls, two of them being monozygotic twins, are affected with acanthosis nigricans and hirsutism, which worsened at the time of their puberty. The first one has primary amenorrhea and the twins complain of spaniomenorrhea. Furthermore, laboratory data concluded to diabetes, hyperinsulinism and resistance to insulin. This rare association of syndromes is not accidental but its significance remains unknown.
mesh_terms: D000052:Acanthosis Nigricans / Q000150:complications*; D000293:Adolescent; D002648:Child; D048909:Diabetes Complications; D004200:Diseases in Twins; D005260:Female; D006628:Hirsutism / Q000150:complications*; D006801:Humans; D006946:Hyperinsulinism / Q000150:complications; D007333:Insulin Resistance; D008599:Menstruation Disturbances / Q000150:complications; D011085:Polycystic Ovary Syndrome / Q000150:complications
vernacular_title: Acanthosis nigricans, hirsutisme et diabète insulino-résistant.