The relationship of plasma arginine and kidney arginase activity to arginine degradation in chickens.
Experiments were carried out to study urea excretion during arginine or ornithine infusion into wing veins of hens previously fed diets that induced different arginase levels in their kidneys. Urea excretion was found to increase as plasma arginine increased. Hens with high levels of arginase activity in their kidneys had a greater increase in urea excretion than hens with low kidney arginase activity. Arginine degradation was also dependent on both the kidney arginase activity and on the plasma level of arginine. Ornithine infusion did not inhibit urea excretion even when high levels of plasma ornithine were reached. Even though ornithine was an in vitro inhibitor of arginase, no evidence was obtained of in vivo inhibition.
D000818:Animals; D001119:Arginase / Q000378:metabolism*; D001120:Arginine / Q000097:blood / Q000378:metabolism*; D002645:Chickens / Q000378:metabolism*; D005260:Female; D007668:Kidney / Q000201:enzymology*; D008239:Lysine / Q000378:metabolism; D009952:Ornithine / Q000378:metabolism / Q000494:pharmacology; D013997:Time Factors; D014508:Urea / Q000378:metabolism
D014508:Urea; D001120:Arginine; D009952:Ornithine; D001119:Arginase; D008239:Lysine