title: Decrease of inhibitory driving force in crayfish stretch reception: a mechanism of the convulsant action of penicillin.
abstract: The effect of penicillin on the evoked IPSP was investigated in the isolated crayfish stretch receptor. The IPSP driving force (IPSP reversal potential minus membrane potential) was reduced in a dose-dependent fashion but, when necessary correction was made for the decrease in resting membrane conductance, the synaptic conductance was only slightly reduced. The possibility that a penicillin-induced intracellular acidification was responsible for the decrease in IPSP driving force is considered.
mesh_terms: D000818:Animals; D003400:Astacoidea; D002463:Cell Membrane Permeability / Q000187:drug effects; D002712:Chlorides / Q000378:metabolism; D003292:Convulsants / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D008465:Mechanoreceptors / Q000187:drug effects*; D010406:Penicillins / Q000494:pharmacology*; D013570:Synaptic Membranes / Q000187:drug effects*
chemical_list: D002712:Chlorides; D003292:Convulsants; D010406:Penicillins