Polyamine inhibition of the conversion of human proacrosin to acrosin.
The conversion of human proacrosin to acrosin was inhibited by polyamines. The order of effectiveness was spermine greater than spermidine greater than cadaverine greater than putrescine greater than 1,3,-diaminopropane. These results are similar to those obtained for the conversion of boar proacrosin to acrosin. Unlike the effects on boar acrosin, however, polyamines did not affect the esterolytic activity of human acrosin but had a slight stimulatory effect on the proteolytic activity of human acrosin.
D000176:Acrosin / Q000378:metabolism*; D003864:Depression, Chemical; D010450:Endopeptidases / Q000378:metabolism*; D004789:Enzyme Activation / Q000187:drug effects; D004792:Enzyme Precursors / Q000378:metabolism*; D006801:Humans; D011073:Polyamines / Q000494:pharmacology*; D013096:Spermine / Q000494:pharmacology
D004792:Enzyme Precursors; D011073:Polyamines; D013096:Spermine; D010450:Endopeptidases; D000176:Acrosin