[Content of lipids and their fractions in erythrocyte membranes of rats with Guerin's carcinoma, A-avitaminosis and the effect of vitamin A in significant doses].
The content of lipids in rat erythrocyte membranes was studied with vitamin A deficiency, Guerin's carcinoma and with administration of significant doses of vitamin A. It is found that vitamin A deficiency decreases the content of phospholipid fractions: phosphatidyl ethanolamine, sphingomyelin, phosphatidyl serine. The content of phosphatidyl choline is unchanged. Under conditions of the experiment the content of cholesterol decreases. This dependence is lost when calculating per 1 g of protein. In erythrocytes of rats with Guerin's carcinoma the content of lipids increases. The character of the results is unchanged when calculating per 1 mg of protein. When administering 200.000 IU of vitamin A the content of the phospholipid and free cholesterol identified fractions lowers significantly.
D000818:Animals; D002784:Cholesterol / Q000097:blood; D004305:Dose-Response Relationship, Drug; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism*; D008297:Male; D008563:Membrane Lipids / Q000097:blood*; D009374:Neoplasms, Experimental / Q000097:blood*; D010743:Phospholipids / Q000097:blood; D051381:Rats; D014801:Vitamin A / Q000494:pharmacology*; D014802:Vitamin A Deficiency / Q000097:blood*
D008563:Membrane Lipids; D010743:Phospholipids; D014801:Vitamin A; D002784:Cholesterol
Soderzhanie lipidov i ikh fraktsiĭ v membranakh eritrotsitov krys pri kartsinome gerena, A-avitaminoze i deĭstvii vysokikh doz vitamina A.