Cimetidine: effect on pancreatic and biliary function in man.
1 Pancreatic and biliary function were studied in eight patients taking oral cimetidine (1.6 g/day for 6 weeks) for endoscopically confirmed active peptic ulcer disease. 2 Postprandial jejunal tryptic activity and bile acid concentration were unchanged during cimetidine given for 1 and 6 weeks. 3 Postprandial gallbladder emptying was also unchanged. 4 Direct examination of postprandial upper jejunal aspirate for deconjugated bile acids was negative in all patients; but the more sensitive [14C]-glycocholate bile acid breath test showed a significant increase in breath 14CO2, indicating increased bacterial deconjugation of bile acids in the gastrointestinal tract.
D000328:Adult; D000368:Aged; D001646:Bile / Q000187:drug effects*; D001647:Bile Acids and Salts / Q000032:analysis; D001944:Breath Tests; D002927:Cimetidine / Q000494:pharmacology*; D004435:Eating; D005260:Female; D005704:Gallbladder / Q000502:physiology; D006146:Guanidines / Q000494:pharmacology*; D006801:Humans; D007583:Jejunum / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000187:drug effects*; D013997:Time Factors
D001647:Bile Acids and Salts; D006146:Guanidines; D002927:Cimetidine