The differing effects of isoxsuprine on muscle flap and skin flap survival in the pig.
The pretreatment of pigs with isoxsuprine for two weeks resulted in a significant increase in the surviving length of sartorius muscle flaps when compared with untreated flaps on the same animal. However, there was no improvement in the surviving length of neurovascular island skin flaps when these animals were treated with isoxsuprine. The difference in these results is thought to be due to the action of isoxsuprine on the blood supply of skeletal muscle.
D000818:Animals; D006085:Graft Survival; D007556:Isoxsuprine / Q000494:pharmacology*; D009132:Muscles / Q000098:blood supply / Q000187:drug effects / Q000601:surgery*; D012867:Skin / Q000098:blood supply* / Q000187:drug effects; D013524:Surgical Flaps; D013552:Swine; D013997:Time Factors
D007556:Isoxsuprine