Structural modifications in membrane glycoproteins during the erythrocyte life-span.
Erythrocyte membrane glycoproteins undergo various types of modification during the life of the cell in the circulation; when only sialic acid is removed, the younger red cells can be repaired in the liver and return to the circulation. Otherwise, when an autolytic mechanism removing a sialopeptide becomes active as a consequence of the metabolic impairment of the cell, the erythrocyte is probably trapped by the hemocatheretic organs and destroyed.
D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D002453:Cell Cycle; D004905:Erythrocyte Aging; D004910:Erythrocyte Membrane / Q000378:metabolism*; D004912:Erythrocytes / Q000166:cytology / Q000378:metabolism*; D005978:Glutathione / Q000494:pharmacology; D006023:Glycoproteins / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D009439:Neuraminidase / Q000378:metabolism; D011817:Rabbits; D012794:Sialic Acids / Q000378:metabolism
D006023:Glycoproteins; D008565:Membrane Proteins; D012794:Sialic Acids; D000255:Adenosine Triphosphate; D009439:Neuraminidase; D005978:Glutathione