Serotonin uptake and release by platelets adhering to polyethylene.
Heparinized human blood containing platelets labelled with 14C-serotonin and 51Cr was exposed to a polyethylene surface by rotation in Chandler loops. Both uptake of platelets on the surface and platelet aggregation in the blood occurred. More 14C- than 51Cr activity accumulated on the surface. It was demonstrated that this was due to an active uptake of 14C-serotonin by the surface-adherent platelets, which also retained their capacity to exert a release reaction.
D001792:Blood Platelets / Q000502:physiology*; D002250:Carbon Radioisotopes; D002860:Chromium Radioisotopes; D006801:Humans; D010973:Platelet Adhesiveness; D011095:Polyethylenes; D012701:Serotonin / Q000378:metabolism*
D002250:Carbon Radioisotopes; D002860:Chromium Radioisotopes; D011095:Polyethylenes; D012701:Serotonin