title: Deficiency of arginine and lysine causes increase in the frequency of sister chromatid exchanges.
abstract: An increase in the rate of sister chromatid exchanges (SCE) was found when V79 Chinese hamster cells were exposed to increasingly severe degrees of arginine and lysine deficiency. The data suggest a possible function of chromosomal proteins, and of histones in particular, in the maintenance of the low normal rate of SCE.
mesh_terms: D000818:Animals; D001120:Arginine / Q000378:metabolism*; D002455:Cell Division; D002460:Cell Line; D006224:Cricetinae; D003434:Crossing Over, Genetic; D004247:DNA / Q000096:biosynthesis; D004261:DNA Replication; D006657:Histones / Q000096:biosynthesis; D008239:Lysine / Q000378:metabolism*; D008938:Mitosis; D012854:Sister Chromatid Exchange
chemical_list: D006657:Histones; D004247:DNA; D001120:Arginine; D008239:Lysine