title: Visualization of the barrier layer through iontophoresis of ferric ions.
abstract: The barrier layer in the intact epidermis of pig skin effectively limits the penetration of ferric ions even under conditions of iontophoresis. This was microscopically demonstrated using a ferric ion salt in conjunction with a soluble ferrocyanide to produce a Prussian blue ferric ferrocyanide precipitate. The effectiveness of various skin preparation techniques in breaking through the epidermal barrier layer was examined, utilizing this chemical reaction to stain the skin.
mesh_terms: D000818:Animals; D006801:Humans; D007477:Ions; D007478:Iontophoresis; D007501:Iron / Q000378:metabolism*; D008566:Membranes / Q000033:anatomy & histology; D010539:Permeability; D012867:Skin / Q000033:anatomy & histology / Q000166:cytology / Q000378:metabolism*; D013552:Swine
chemical_list: D007477:Ions; D007501:Iron