Effect of food on absorption of erythromycin. A study of two derivatives, the stearate and the base.
Two derivatives of erythromycin, the stearate and the enteric-coated base have been given in a cross-over study to both fasting and non-fasting volunteers. The stearate gave higher plasma concentrations in non-fasting than in fasting subjects. The area under the curve was significantly larger during steady state day 7 than after a single dose. The base showed larger individual variations in concentrations. The release of the drug from the enteric-coated tablets was depressed by food, but the absorption was not prevented.
D000328:Adult; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000378:metabolism; D005215:Fasting; D005260:Female; D005502:Food; D006207:Half-Life; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D013228:Stearates / Q000378:metabolism; D013608:Tablets, Enteric-Coated
D013228:Stearates; D013608:Tablets, Enteric-Coated; D004917:Erythromycin