title: Comparative effects of protracted protein deprivation on the DNA synthetic and mitogenic actions of phytohemagglutinin and concanavalin A in vivo on the lymphocytes of the rat.
abstract: The increase rate of DNA synthesis and mitotic activity in popliteal lymph nodes following subplantar injection of PHA was significantly reduced in rats subjected to a protein-free diet given for 9 weeks. On the contrary, the lymph node responses to Con A were higher with latter diet than with a balanced 18% casein diet. On the other hand, PHA reduced the weight and proliferative activity of the thymus, and probably also increased the emigration of thymocytes in protein deprived rats, while Con A was devoid of any effects. Thus, mainly the activity of the PHA-responsive subset of T lymphocytes and thymocytes appeared to be disturbed after protein deprivation. According to previous work, this subset was formed of high theta, cortisone-sensitive celles.
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects; D003208:Concanavalin A / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis*; D008198:Lymph Nodes / Q000187:drug effects; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008938:Mitosis / Q000187:drug effects*; D009929:Organ Size / Q000187:drug effects; D010835:Phytohemagglutinins / Q000494:pharmacology*; D011488:Protein Deficiency / Q000378:metabolism*; D051381:Rats; D013154:Spleen / Q000187:drug effects; D013950:Thymus Gland / Q000187:drug effects
chemical_list: D010835:Phytohemagglutinins; D003208:Concanavalin A; D004247:DNA