Gentamicin pharmacokinetics in kwashiorkor.
1 Single dose intravenous gentamicin kinetics (2.4 mg/kg) were studied in six children with kwashiorkor. It was observed, that therapeutic drug concentrations were achieved which should be neither oto- nor nephrotoxic. 2 Due to the diminished glomerular filtration and renal plasma flow seen in the acute phase of kwashiorkor, gentamicin half-life was prolonged (229.0 +/- 94.8 min) at this time returning to normal (178.5 +/- 99.5 min) with nutritional rehabilitation.
D000328:Adult; D005839:Gentamicins / Q000097:blood / Q000378:metabolism*; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D007732:Kwashiorkor / Q000378:metabolism*; D008297:Male; D010130:p-Aminohippuric Acid / Q000097:blood
D005839:Gentamicins; D010130:p-Aminohippuric Acid