Fenbendazole for treatment of Paragonimus kellicotti infection in dogs.
The effect of fenbendazole therapy was studied in 9 dogs with pulmonary paragonimiasis induced by inoculation of metacercariae (25/dog) of Paragonimus kellicotti. At 42 to 47 days after 6 dogs were inoculated, they were given fenbendazole in 2 divided doses totaling 50 mg (4 dogs) or 100 mg (2 dogs)/kg of body weight each day for 10 to 14 days. Three dogs were not treated. The passage of Paragonimus eggs in the feces ceased after 3 days at the high dosage and after 3 to 8 days at the low dosage. All dogs were euthanatized and necropsied on day 14. Live flukes were not recovered from the lungs of any treated dog, but 15, 19, and 23 live flukes were recovered from the untreated dogs.
D000818:Animals; D001562:Benzimidazoles / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy* / Q000473:pathology; D004285:Dogs; D005260:Female; D005273:Fenbendazole / Q000627:therapeutic use*; D008168:Lung / Q000473:pathology; D008297:Male; D010237:Paragonimiasis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*
D001562:Benzimidazoles; D005273:Fenbendazole