Primary pulmonary hypertension. Responses to indomethacin, terbutaline, and isoproterenol.
Primary pulmonary hypertension remains a difficult therapeutic problem. Sublingual isoproterenol (Isuprel) has been effective in a few cases but the every-two-hour dosage schedule is inconvenient on a long-term basis. A case of primary pulmonary hypertension is described in which terbutaline sulfate and indomethacin were given a trial. There was no sustained response to terbutaline but there seemed to be a response to indomethacin and isoproterenol.
D000293:Adolescent; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy*; D007213:Indomethacin / Q000627:therapeutic use*; D007545:Isoproterenol / Q000627:therapeutic use*; D011448:Prostaglandin Antagonists / Q000627:therapeutic use; D013726:Terbutaline / Q000627:therapeutic use*
D011448:Prostaglandin Antagonists; D007545:Isoproterenol; D013726:Terbutaline; D007213:Indomethacin