The specificity of potentiating effect of glutathione on the actions of bradykinin.
Potentiating effects of GSH, a physiologic kininase inhibitor on the bradykinin actions on (a) blood pressure responses of rabbits, (b) acute inflammatory response in rat's hind paws and (c) the isolated guinea-pig ileum contractions were examined among the combinations between various active agents and thiols. The potentiation of the hypotensive response to bradykinin by GSH was highly specific compared with the other experimental models (B and C). Throughout these three experiments, specific relation between GSH and bradykinin was consistently observed.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001920:Bradykinin / Q000378:metabolism*; D004357:Drug Synergism; D004487:Edema / Q000503:physiopathology*; D005978:Glutathione / Q000494:pharmacology*; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D007700:Kinetics; D009119:Muscle Contraction / Q000187:drug effects; D051381:Rats
D005978:Glutathione; D001920:Bradykinin