title: [Assessment of the dimensions and dynamics of the necrosis zone in acute myocardial infarct].
abstract: In 165 patients with myocardial infarction admitted to the clinic within the first 24 hours of the disease, the size of the zone of affection and its dynamics in the immediate 4--5 days were appraised. Three methods were used for this purpose: cartographic analysis of the ECG in 35 precordial leads; vectorcardiography and serial determination of creatine phosphokinase activity (CPK) in blood plasma with calculation of the size of the necrosis in units of weight (grams). It is shown that ECG-cartography and serial determination of serum CPK activity are valuable methods in quantitative appraisal of the size of the necrotic focus in patients with myocardial infarction. Study of the ECG-cardiogram and vectorcardiogram in dynamics and analysis of CPK activity curves enables one to appraise the spreading of the zone of the necrosis in the first days of the infarction. According to the results of these methods, in most patients (68 to 82%) with macrofocal myocardial infarction the zone of the necrosis spreads in length and in depths in the first days of the disease.
mesh_terms: D000328:Adult; D000368:Aged; D003402:Creatine Kinase / Q000097:blood; D004562:Electrocardiography; D004789:Enzyme Activation; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000503:physiopathology*; D009336:Necrosis; D013997:Time Factors; D014672:Vectorcardiography
chemical_list: D003402:Creatine Kinase
vernacular_title: Otsenka razmerov i dinamiki zony nekroza u bol'nykh ostrym infarktom miokarda.