Effect of probenecid on cerebrospinal fluid methotrexate kinetics.
The effect of probenecid (PBC) on methotrexate (MTX) kinetics in the cerebrospinal fluid (CSF) and serum was studied in 4 patients on high-dose MTX with leucovorin rescue to determine whether addition of PBC could prolong effective CSF MTX levels. Each patient received 2 courses of MTX, 1 with and 1 without PBC. PBC caused a 2.8 to 4.2-fold increase in CSF MTX concentrations but failed to prolong the CSF half-life (1 1/2). PBC prolonged the initial MTX elimination t 1/2 in the blood from 2.7 to 4.1 hr, but had little effect on subsequent t 1/2s. No effect of MTX on PBC clearance was detected. Our data suggest that in man PBC in concentrations that were high enough to inhibit the renal clearance of MTX failed to alter the clearance of MTX from the CSF when both drugs were administered systemically.
D000328:Adult; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007700:Kinetics; D008727:Methotrexate / Q000097:blood / Q000134:cerebrospinal fluid* / Q000627:therapeutic use; D008875:Middle Aged; D009369:Neoplasms / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D011339:Probenecid / Q000627:therapeutic use*
D011339:Probenecid; D008727:Methotrexate