[Sulfalene pharmacogenetics. II. The population genetic aspect].
Half-life of sulfalen, a new antibacterial drug, with the biotransformation, performed by means of microsomal acetyltransferase, has been studied in 53 individuals of Moscow Russian population. The absence of sex dimorphism for the trait studied is demonstrated. Distribution of individuals according to values of the pharmacokinetic parameter mentioned within the population is bimodal with the correlation of phenotypic frequencies of "rapid" and "slow" inactivators--72 and 28%. Possible causes of discrepancies between the observed sulfalen inactivator frequencies and similar data on isoniazid are discussed.
D000284:Administration, Oral; D001711:Biotransformation; D005260:Female; D005828:Genetics, Population / Q000187:drug effects*; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D009031:Moscow; D010597:Pharmacogenetics; D010641:Phenotype; D013415:Sulfalene / Q000097:blood*; D013424:Sulfanilamides / Q000097:blood*; D013997:Time Factors
D013424:Sulfanilamides; D013415:Sulfalene
Farmakogenetika sul'falena. Soobshchenie II. Populiatsionno--geneticheskiĭ aspekt.