Effects of corticosteroids and local anaesthetics applied directly to the synovial vascular bed.
The effects of intra-articular injection of triamcinolone hexacetonide on the rate of clearance of radioactive xenon (133Xe) was studied in 11 patients with rheumatoid arthritis. No effect of the corticosteroid injection was observed, which suggests that the drug has no immediate effect on synovial blood vessels.
D001172:Arthritis, Rheumatoid / Q000503:physiopathology*; D006207:Half-Life; D006801:Humans; D007270:Injections, Intra-Articular; D007719:Knee Joint; D008012:Lidocaine / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000187:drug effects; D013583:Synovial Membrane / Q000098:blood supply* / Q000187:drug effects; D014222:Triamcinolone Acetonide / Q000494:pharmacology*; D014980:Xenon Radioisotopes
D014980:Xenon Radioisotopes; D008012:Lidocaine; D014222:Triamcinolone Acetonide