Sequential study of C 1 q-binding substances and of anti-DNA antibodies in (NZB X NZW)F1 mice: evidence for an acute phase of the lupus disease in 2-month-old mice.
Longitudinal studies of C 1 q and DNA-binding substances were performed in sera from 38 (NZB X NZW)F1 female mice between days 39 and 150 of life. Results suggest a two-phase evolution of circulating immune complexes and anti-DNA antibodies in young (NZB X NZW)F1 mice and show the existence of an acute phase of the disease during the second month of life of these mice.
D000208:Acute Disease; D000818:Animals; D000906:Antibodies / Q000276:immunology*; D000936:Antigen-Antibody Complex; D001665:Binding Sites; D003172:Complement C1 / Q000276:immunology*; D004247:DNA / Q000276:immunology*; D005260:Female; D005921:Glomerulonephritis / Q000150:complications / Q000276:immunology*; D008177:Lupus Vulgaris / Q000150:complications / Q000276:immunology*; D051379:Mice; D008814:Mice, Inbred NZB; D013997:Time Factors
D000906:Antibodies; D000936:Antigen-Antibody Complex; D003172:Complement C1; D004247:DNA