[The influence of 2-acetylaminofluorene on the dietary induction of pentose phosphate pathway enzymes (author's transl)].
The influence of feeding 2-acetylaminofluorene on the dietary induction of the enzymes glucose-6-phosphate dehydrogenase, and 6-phosphogluconate dehydrogenase by a fasting-refeeding regime was investigated in the liver of hooded rats. After feeding a diet containing 0,03% acetylaminofluorene for two weeks, the induced activity of glucose-6-phosphate dehydrogenase was diminished significantly; after feeding this carcinogen either for 4 weeks or for 4 weeks followed by feeding carcinogen-free diet for 2 weeks, the diminution of the induction was hardly perceptible. In case of 6-phosphogluconate dehydrogenase the diminution of the induction was only slightly expressed, without statistical significance.
D015073:2-Acetylaminofluorene / Q000494:pharmacology*; D000818:Animals; D004032:Diet; D004790:Enzyme Induction / Q000187:drug effects; D005215:Fasting; D005954:Glucosephosphate Dehydrogenase / Q000096:biosynthesis; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D010428:Pentosephosphates / Q000378:metabolism*; D010734:Phosphogluconate Dehydrogenase / Q000096:biosynthesis; D051381:Rats; D013997:Time Factors
D010428:Pentosephosphates; D015073:2-Acetylaminofluorene; D010734:Phosphogluconate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase
Die Einwirkung von 2-Azetylaminofluoren auf die alimentäre Regulation von Enzymen des Pentosephosphat-Weges in der Rattenleber.