Prostaglandins and congeners XXIII (1). Synthesis of 15-deoxy-16-hydroxy-16-methylprostanglandins. The importance of the C13--C14 trans double bond for bronchodilator activity.
The synthesis and bronchodilator activity in the guinea pig of several 15-deoxy-16-hydroxy-16-methylprostaglandin analogs is described. The E2 (VIa) and E1 (VIb) analogs are potent bronchodilators comparable in activity to the natrual prostaglandins, but possessing a longer duration of effect. Replacement of the C13--C14 trans double bond by a cis double bond or an ethylene linkage causes a substantial diminishment of this activity.
D000818:Animals; D001993:Bronchodilator Agents; D055598:Chemical Phenomena; D002621:Chemistry; D006168:Guinea Pigs; D011459:Prostaglandins E, Synthetic / Q000138:chemical synthesis* / Q000494:pharmacology
D001993:Bronchodilator Agents; D011459:Prostaglandins E, Synthetic