Digoxin overdose. Limitations of hemoperfusion-hemodialysis treatment.
We used charcoal hemoperfusion coupled with hemodialysis to treat a woman with massive digoxin ingestion complicated by hyperkalemia. Although dialysis controlled the serum potassium levels, hemoperfusion removed less than 1% of the total ingested dose. Hemoperfusion has a relatively minor impact on digoxin elimination and remains of unproved value in the therapy for digoxin overdose.
D000328:Adult; D001145:Arrhythmias, Cardiac / Q000517:prevention & control; D002606:Charcoal / Q000008:administration & dosage; D004077:Digoxin / Q000097:blood / Q000378:metabolism / Q000506:poisoning*; D005260:Female; D006464:Hemoperfusion / Q000379:methods*; D006801:Humans; D006947:Hyperkalemia / Q000628:therapy; D009206:Myocardium / Q000166:cytology / Q000378:metabolism; D011188:Potassium / Q000378:metabolism; D006435:Renal Dialysis / Q000379:methods*
D002606:Charcoal; D004077:Digoxin; D011188:Potassium