title: Nylidrin HCL in the treatment of symptoms of the aged: a double-blind placebo controlled study.
abstract: This study was designed to assess the effectiveness and the safety of nylidrin HCL in the geriatric patient and mild to moderate symptoms of cognitive, emotional and physical impairment. Following a 3 week placebo washout, 60 patients received either nylidrin HCL or placebo for 12 weeks. Efficacy evaluations were made utilizing the Sandoz Clinical Assessment Geriatric (SCAG) Scale, a nurse's rating of ward behavior (SCASNO), the Hamilton Psychiatric Rating Scale for Depression, and 2 of the Katz Adjustment Scales. Significant improvement in symptom severity was demonstrated in the nylidrin group as compared to the placebo group. There were no abnormalities of clinical significance in the safety measurements and few side effects were reported.
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D003863:Depression / Q000175:diagnosis / Q000523:psychology; D004311:Double-Blind Method; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000188:drug therapy*; D019965:Neurocognitive Disorders / Q000188:drug therapy* / Q000523:psychology; D009756:Nylidrin / Q000009:adverse effects / Q000627:therapeutic use*; D010919:Placebos; D011569:Psychiatric Status Rating Scales
chemical_list: D010919:Placebos; D009756:Nylidrin