title: Age as a function in the development of sodium-related hypertension.
abstract: The populations of the developed nations of the world exhibit an increase in blood pressure with age, while in primitive societies blood pressure remains relatively constant throughout adult life. Hypertension may be a complex of diseases all having the same clinical manifestations but not being caused necessarily by the same factors. A possible common denominator in the development of any chronic elevation of blood pressure is the need for the kidney to increase urine volume to promote sodium excretion and, thereby, prevent a chronically expanded extracellular fluid (ECF). Hypertension may be viewed as a maladaptation of the body in its attempt to maintain homeostasis of the ECF. Man evolved under conditions of relative scarcity of salt and even now can maintain normal body function with an intake of less than 2 g/day. The high risk person appears to have a hereditary predisposition to a rise in blood pressure in the presence of a high sodium (NaCl) intake. Actually, the degree of rise in blood pressure may be an interaction between the amount of genetic predisposition and the level of sodium and its relation to potassium intake. Recent work in two Massachusetts communities supports this interpretation and suggests that differences in blood pressure distribution may increase with age between a higher and lower sodium community.
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000818:Animals; D002648:Child; D004032:Diet; D005110:Extracellular Space / Q000378:metabolism; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism*; D008297:Male; D008404:Massachusetts; D011188:Potassium / Q000378:metabolism / Q000652:urine; D044469:Racial Groups; D051381:Rats; D012737:Sex Factors; D012959:Socioeconomic Factors; D012964:Sodium / Q000378:metabolism* / Q000652:urine; D014881:Water Supply
chemical_list: D012964:Sodium; D011188:Potassium