Restoration by serum thymic factor of colony-forming unit (CFU-S) entry into DNA synthesis in thymectomized mice after T-dependent antigen treatment.
Adult thymectomy prevents stimulation of hematopoietic stem cells as measured by colony-forming units (CFU-S) if T-dependent antigens are injected, but not when T-independent antigens are used. This can be observed as soon as 10 to 15 days after thymectomy. The serum thymic factor can restore CFU-S response to T-dependent antigens in thymectomized mice.
D000818:Animals; D000941:Antigens; D002266:Carboxymethylcellulose Sodium / Q000494:pharmacology; D003114:Colony-Forming Units Assay; D004247:DNA / Q000096:biosynthesis*; D051379:Mice; D008808:Mice, Inbred CBA; D010081:Oxazolone / Q000494:pharmacology; D013154:Spleen / Q000637:transplantation; D013934:Thymectomy; D013935:Thymic Factor, Circulating / Q000494:pharmacology*; D013950:Thymus Gland / Q000276:immunology*; D013951:Thymus Hormones / Q000494:pharmacology*; D014184:Transplantation, Homologous; D014185:Transplantation, Isogeneic
D000941:Antigens; D013951:Thymus Hormones; D010081:Oxazolone; D004247:DNA; D013935:Thymic Factor, Circulating; D002266:Carboxymethylcellulose Sodium