[Glucose-6-phosphate dehydrogenase and transketolase activity in the blood of neurological oncologic patients preoperatively and in the dynamics of the postoperative period].
Brain benign tumors /hypophyseal adenoma, meningeoma/ caused definite effects on the enzymes of pentosephosphate pathway in blood of patients. Distinct decrease in glucose-6-phosphate dehydrogenase /G6PD/ activity was observed in erythrocytes of patients with adenoma of hypophysis as compared with a control group; transketolase /TK/ activity was unaltered. In blood of patients with brain meningeomas the G6PD was activated by 8% and TK - by 36%. Within the first day after resection of the tumors activity of the enzymes was distinctly increased; it remained markedly higher than the enzymatic activity before the operation within all the periods studied /5-7 days and 10-15 days after the operation/.
D000236:Adenoma / Q000201:enzymology; D000328:Adult; D001932:Brain Neoplasms / Q000201:enzymology*; D004789:Enzyme Activation; D005954:Glucosephosphate Dehydrogenase / Q000097:blood*; D006801:Humans; D008577:Meningeal Neoplasms / Q000201:enzymology; D008579:Meningioma / Q000201:enzymology; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000201:enzymology; D011184:Postoperative Period; D014174:Transketolase / Q000097:blood*
D005954:Glucosephosphate Dehydrogenase; D014174:Transketolase
Aktivnost' gliukozo-6-fosfatdegidrogenazy i transketolazy v krovi neĭroonkologicheskikh bol'nykh do operatsii i v dinamike postoperatsionnogo periods.