Iron deficiency in the rat: effects on phenylalanine metabolism.
Concentrations of phenylalanine in the plasma were markedly elevated in iron-deficient rats and appeared to vary directly with the degree of iron deficiency. Plasma concentrations of phenylalanine returned to control levels within one week after treatment of the iron-deficient rats with iron dextran. The elevated levels of plasma phenylalanine were probably not produced by a deficiency in liver phenylalanine hydroxylase because levels of activity of the enzyme were found to be normal in the livers of the iron-deficient animals.
D000818:Animals; D000090463:Iron Deficiencies; D007505:Iron-Dextran Complex / Q000627:therapeutic use; D008099:Liver / Q000201:enzymology; D008297:Male; D010649:Phenylalanine / Q000097:blood / Q000378:metabolism*; D010651:Phenylalanine Hydroxylase / Q000172:deficiency / Q000378:metabolism; D051381:Rats
D010649:Phenylalanine; D007505:Iron-Dextran Complex; D010651:Phenylalanine Hydroxylase