Problems of dose-response studies in chemical carcinogenesis with special reference to N-nitroso compounds.
Dose-response studies in chemical carcinogenesis are a valuable method for evaluating the risk involved by a certain carcinogen. This article deals with the methods that are presently applied for dose-response studies. It is emphasized that there are many possible mistakes that are already hidden in the method itself; a critical approach is made to the indicative value of dose-response studies. It is also emphasized that the conclusions which may be drawn from dose-response studies can always only be extrapolative but never mathematically calculable. Finally, some practical examples for dose-response studies with n-nitroso compounds are described.
D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D002455:Cell Division / Q000187:drug effects; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000633:toxicity; D004052:Diethylnitrosamine / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008770:Methylnitrosourea / Q000633:toxicity; D009603:Nitroso Compounds / Q000633:toxicity*; D009607:Nitrosourea Compounds / Q000633:toxicity; D051381:Rats; D013045:Species Specificity; D013329:Structure-Activity Relationship
D002273:Carcinogens; D009603:Nitroso Compounds; D009607:Nitrosourea Compounds; D004052:Diethylnitrosamine; D008770:Methylnitrosourea; D003520:Cyclophosphamide