title: Amino acid sequence of a postsynaptic neurotoxin from the venom of the Australian tiger snake Notechis scutatus scutatus.
abstract: Although 60 percent of the protein in tiger snake (Notechis scutatus scutatus) venom consists of the basic per-synaptically neurotoxic and myotoxic phospholipases notexin and Notechis II-5 and other phospholipase homologs such as Notechis II-1, several post-synaptic "curaremimetic" neurotoxins are present in small amounts. The major one of these is a typical "long" neurotoxin containing 73 amino acids in a single peptide chain cross-linked by five disulfide bridges. The formula weight calculated from the amino acid sequence is 8,051. The LD50 for intravenous injection into mice is 125 micrograms/kg.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D004546:Elapid Venoms; D007928:Lethal Dose 50; D051379:Mice; D009498:Neurotoxins; D010446:Peptide Fragments
chemical_list: D004546:Elapid Venoms; D009498:Neurotoxins; D010446:Peptide Fragments