[Mechanism of the effect of immobilized noradrenaline on the contact phase of blood coagulation].
A deficiency in the contact phase of blood coagulation, depending on the specific isolation of Fletcher's factor (prekallikreins) from blood plasma, was observed after chromatography of blood plasma on a column with noradrenaline-Sepharose. Activation of kalliklein and dekinination of high-molecular kininogene occurred after the interaction between proenzymes of contact phase of blood coagulation (factor XII, prekallikreins, high-molecular kininogene).
D000293:Adolescent; D000328:Adult; D001667:Binding, Competitive; D001777:Blood Coagulation / Q000187:drug effects*; D001779:Blood Coagulation Factors / Q000502:physiology; D001780:Blood Coagulation Tests; D002846:Chromatography, Affinity; D002850:Chromatography, Gel; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000494:pharmacology; D012685:Sepharose
D001779:Blood Coagulation Factors; D012685:Sepharose; D009638:Norepinephrine
O mekhanizme vliianiia immobilizovannogo noradrenalina na kontaktnuiu fazu svertyvaniia krovi.