title: Porphobilinogen synthetase activity response to increased levels of reduced glutathione produced by methylene blue, in blood, liver and kidney.
abstract: We have studied the effect of methylene blue on GSH and GSSG levels in rat blood, liver and kidney. Methylene blue treatment increases GSH levels and PBG-synthetase activity in erythrocytes while liver and kidney GSH and GSSG levels remain constant. These results indicate that methylene blue effect on PBG-synthetase activity in rat erythrocytes is mediated by an increase in blood GSH levels.
mesh_terms: D000818:Animals; D004912:Erythrocytes / Q000378:metabolism; D005978:Glutathione / Q000097:blood / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D008751:Methylene Blue / Q000494:pharmacology*; D010084:Oxidation-Reduction; D000623:Porphobilinogen Synthase / Q000097:blood / Q000378:metabolism*; D051381:Rats
chemical_list: D000623:Porphobilinogen Synthase; D005978:Glutathione; D008751:Methylene Blue