Some behavioral effects of histamine H1-, and H2-receptor agonists in rats.
2-Pyridylethylamine (2-PEA) and 4-methylhistamine (4-MeHI) when given intraventricularly at doses of 30 and 100 microgram had no discernible effect on spontaneous locomotor activity and did not visibly change gross behavior of rats. 4-MeHI(100 micrograms) injected to tranylcypromine-pretreated rats increased locomotor activity and induced head twitches. Locomotor activation was not antagonized by either cimetidine or metergoline but was prevented by alpha-methyl-p-tyrosine and haloperidol and reduced by phentolamine. 4-MeHI-, and histamine (HI)-induced head twitches were not antagonized by either cimetidine or metiamide but were completely abolished by metergoline and p-chlorophenylalanine. It is concluded that 4-MeHI--induced locomotor activation and both HI-, and 4-MeHI-induced head twitches are respectively catecholamine-, and serotonin-dependent phenomena. The behavioral effects of HI and HI H1-and H2-receptor agonists are discussed with regard to possible HI interactions with both catecholamine and serotonin systems in brain.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002927:Cimetidine / Q000494:pharmacology; D004347:Drug Interactions; D005021:Ethylamines / Q000494:pharmacology; D005260:Female; D008711:Metergoline / Q000494:pharmacology; D008761:Methylhistamines / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D011968:Receptors, Histamine / Q000187:drug effects*; D011969:Receptors, Histamine H1 / Q000187:drug effects*; D011970:Receptors, Histamine H2 / Q000187:drug effects*; D013997:Time Factors; D014191:Tranylcypromine / Q000494:pharmacology
D005021:Ethylamines; D008761:Methylhistamines; D011968:Receptors, Histamine; D011969:Receptors, Histamine H1; D011970:Receptors, Histamine H2; D008711:Metergoline; D014191:Tranylcypromine; D002927:Cimetidine