Electrophysiological and haemodynamic effects of a new inotropic agent (UK14275) in the dog.
1. Electrophysiological and haemodynamic effects after intravenous administration of a new inotropic agent (UK14275) have been examined in open-chest dogs under pentobarbitone anaesthesia. 2. UK14275 produced slight shortening of QT interval, ventricular functional refractory period and atrio-ventricular conduction time but did not affect action potential duration or endocardial-epicardial conduction time. 3. Cardiac output and left ventricular dP/dt increased, and systemic vascular resistance fell. 4. An end-systolic pressure gradient developed between left ventricle and aorta attributable to left ventricular cavity obliteration.
D000818:Animals; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D004594:Electrophysiology; D006321:Heart / Q000187:drug effects*; D006329:Heart Conduction System / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D009200:Myocardial Contraction / Q000187:drug effects; D010880:Piperidines / Q000494:pharmacology*; D011799:Quinazolines / Q000494:pharmacology*; D012032:Refractory Period, Electrophysiological / Q000187:drug effects
D010880:Piperidines; D011799:Quinazolines