Pseudoephedrine pharmacokinetics in the rat using a microanalysis technique.
A microanalytical procedure was developed using a gas chromatographic-electron capture technique which is capable of detecting 2 ng pseudoephedrine in 20 microliter plasma samples. Standard curves for pseudoephedrine are linear over the concentration range 0.1--1.6 microgram/ml. Plasma and urine concentrations of pseudoephedrine were followed in 3 rats after intravenous dosing. Derived pharmacokinetics parameters exhibited little inter-animal variation. Average plasma clearance was 67.6 ml/min/kg, with renal clearance averaging 30.3 ml/min/kg. This latter value is approximately 4X the glomerular filtration rate in the rat.
D000818:Animals; D002849:Chromatography, Gas; D004577:Electron Probe Microanalysis; D004809:Ephedrine / Q000097:blood / Q000378:metabolism* / Q000652:urine; D007275:Injections, Intravenous; D051381:Rats
D004809:Ephedrine