title: [Treatment of diabetic patients with insulin resistance and allergy using des-phe-insulin (author's transl)].
abstract: Eleven patients were treated with pure porcine des-phe-insulin (Insulin 02S Hoechst). In seven patients insulin 02S was used because of high insulin requirements. Three cases were treated successfully, one case moderately successfully, there was no success in two cases and in one case the result remains to be seen. In more than half of the patients a considerable decrease of  insulin requirement could thus be achieved. Four patients received insulin 02S because of allergy. Success was evident in three cases and at least probable in the fourth case. Results up to now showing less immunogenicity and antigenicity of des-phe-insulin seem to be confirmed clinically.
mesh_terms: D000368:Aged; D000818:Animals; D003920:Diabetes Mellitus / Q000188:drug therapy*; D004342:Drug Hypersensitivity / Q000188:drug therapy; D005260:Female; D006801:Humans; D007328:Insulin / Q000627:therapeutic use*; D007330:Insulin Antibodies; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D013552:Swine
chemical_list: D007328:Insulin; D007330:Insulin Antibodies
vernacular_title: Behandlung von Diabetikern mit Insulinresistenz und -allergie mit Des-Phe-Insulin. Erste Mitteilung.