Aberrant tonotopic organization in the inner ear damaged by kanamycin.
Spiral ganglion cell recordings were obtained from normal and kanamycin-damaged guinea pig cochleas. Results show that kanamycin poisoning, which causes loss of outer hair cells, leads to a loss of sharp, sensitive tuning and, in addition, a shift to lower frequencies in the tuning curves from a damaged region. The normal tonoptic pattern of organization is therefore greatly disrupted in the damaged cochleas.
D000818:Animals; D001309:Auditory Threshold / Q000187:drug effects; D003051:Cochlea / Q000187:drug effects*; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000187:drug effects; D007612:Kanamycin / Q000494:pharmacology*; D013136:Spiral Ganglion / Q000187:drug effects*
D007612:Kanamycin