title: In vivo and in vitro effects of alloxan on collagen characteristics of bone, skin and tendon of Swiss mice.
abstract: Alloxan diabetes in Swiss mice induced decreased levels of percent solubility of collagen in bone, skin and tendon both after 4 days (96 h) and 28 days of treatment. In vitro treatment of tissues with alloxan in physiological saline did not influence the cross-linking of collagen. It is suggested that in alloxan diabetes, metabolites formed in the tissues might accelerate aging of collagen.
mesh_terms: D000496:Alloxan / Q000494:pharmacology*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism*; D003094:Collagen / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D005260:Female; D051379:Mice; D009928:Organ Specificity; D012867:Skin / Q000187:drug effects / Q000378:metabolism*; D012995:Solubility; D013710:Tendons / Q000187:drug effects / Q000378:metabolism*
chemical_list: D001786:Blood Glucose; D000496:Alloxan; D003094:Collagen