title: The analgesic action of some flavonoids in the hot plate test.
abstract: Albino-Swiss male mice were tested in the hot plate test. Oligomeric procyjanidin (OL-1), rutin, quercetin, hyperoside and vitexin rhamnoside were administered intraperitoneally in doses 3.5 and 10 mg/kg. It was found that OL-1, rutin and hyperoside but not vitexin rhamnoside exert analgesic action, whereas quercetin even decreases the pain threshold level. The mechanism of the analgesic action of flavonoids remains to be explained.
mesh_terms: D000698:Analgesia; D000818:Animals; D047310:Apigenin; D002392:Catechin; D005419:Flavonoids; D005697:Galactosides; D006358:Hot Temperature; D008297:Male; D009020:Morphine; D011108:Polymers; D011794:Quercetin / Q000031:analogs & derivatives; D051381:Rats; D012431:Rutin
chemical_list: D005419:Flavonoids; D005697:Galactosides; D011108:Polymers; C021329:vitexin rhamnoside; D012431:Rutin; D009020:Morphine; D047310:Apigenin; C021304:hyperoside; D002392:Catechin; D011794:Quercetin