[Idiopathic hypercalciuria due to primary decrease in the renal tubular reabsorption of calcium. Hypercalciuria type 2 according to Bordier (author's transl)].
A persistent hypercalciuria and normal serum levels of calcium were measured in a 5-year-old boy suffering from recurrent macro- and microhaematuria and bilateral nephrolithiasis (stone analysis was positive for calcium-oxalate). No growth retardation or any other relevant clinical parameters concerning hypercalciuria e.g. vitamin D-intoxication or renal tubular acidosis could be observed. A slight secondary hyperparathyroidism and increased calcium excretion during fasting or calcium depleted diet indicates a primary failure of calcium reabsorption as previously described by Bordier (hypercalciuria type 2). Treatment with a combination of hydrochlorothiazide (Esidrix) and sodium chloride depleted diet resulted in a long-lasting normalization of calcium excretion and thus disappearance of symptoms in the child.
D002118:Calcium / Q000097:blood / Q000652:urine*; D002675:Child, Preschool; D004039:Diet, Sodium-Restricted; D006417:Hematuria / Q000175:diagnosis; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use; D006962:Hyperparathyroidism, Secondary / Q000175:diagnosis; D007669:Kidney Calculi / Q000097:blood / Q000178:diet therapy / Q000188:drug therapy / Q000652:urine*; D008297:Male
D006852:Hydrochlorothiazide; D002118:Calcium
Idiopathische Hypercalciurie infolge primär gestörter renaler Calcium-Rückresorption. Hypercalciurie Typ 2 nach Bordier.