HLA haplotypes and hayfever: a possible protective role.
The HLA haplotype frequencies of European asthmatic children and their immediate families were studied, and a disassociation between haplotype A1-B8 and skin sensitivity to grass pollens was found, suggesting that within this allergic population, possession of the haplotype A1-B8 conferred possible protection against grass pollinosis. There was no association between A1-B8 and clinical asthma or between it and skin sensitivity to the house dust mite.
D004391:Dust; D006680:HLA Antigens / Q000235:genetics*; D006238:Haploidy; D006801:Humans; D008925:Mites; D011058:Pollen / Q000276:immunology; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology* / Q000517:prevention & control; D012882:Skin Tests
D004391:Dust; D006680:HLA Antigens