Carcinogenicity of N-nitroso-ethylenethiourea in female mice.
The nitrosation product of ethylenethiourea (ETU), N-nitroso-ETU, was tested for tumorigenicity in female ICR mice. Ten weekly oral administrations of this compound (0.66-2.64 mg/dose) caused apparently dose-dependent increases in the number of mice with pulmonary and lymphocytic neoplasms.
D000818:Animals; D002273:Carcinogens; D005031:Ethylenethiourea / Q000031:analogs & derivatives / Q000633:toxicity; D005260:Female; D007093:Imidazoles / Q000031:analogs & derivatives; D007942:Leukemia, Experimental / Q000139:chemically induced; D008175:Lung Neoplasms / Q000139:chemically induced; D008223:Lymphoma / Q000139:chemically induced; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D009603:Nitroso Compounds / Q000633:toxicity*
D002273:Carcinogens; D007093:Imidazoles; D009603:Nitroso Compounds; D005031:Ethylenethiourea