Antitumor agents 37. The isolation and structural elucidation of isohelenol, a new antileukemic sesquiterpene lactone, and isohelenalin from Helenium microcephalum.
The known compound isohelenalin (1) was isolated from Helenium microcephalum and the previously reported structure confirmed on the basis of physicochemical data and chemical transformation. In addition, a new antileukemic sesquiterpene lactone, isohelenol (2), was isolated and its structure elucidated.
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D055598:Chemical Phenomena; D002621:Chemistry; D007783:Lactones / Q000302:isolation & purification; D007938:Leukemia / Q000188:drug therapy; D010946:Plants, Medicinal / Q000032:analysis*; D012717:Sesquiterpenes / Q000302:isolation & purification*; D013237:Stereoisomerism
D000972:Antineoplastic Agents, Phytogenic; D007783:Lactones; D012717:Sesquiterpenes