Inhibition of cholesterol biosynthesis in Chinese hamster ovary cells by 4,4,10 beta-trimethyl-trans-decal-3 beta-ol. A specific 2,3-oxidosqualene cyclase inhibitor.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002784:Cholesterol / Q000096:biosynthesis*; D006224:Cricetinae; D005260:Female; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism; D019751:Intramolecular Transferases; D007535:Isomerases / Q000037:antagonists & inhibitors*; D007700:Kinetics; D007810:Lanosterol; D009284:Naphthols / Q000494:pharmacology*; D010053:Ovary; D013185:Squalene / Q000031:analogs & derivatives
D009284:Naphthols; D007810:Lanosterol; D013185:Squalene; D002784:Cholesterol; D006903:Hydroxymethylglutaryl CoA Reductases; D007535:Isomerases; D019751:Intramolecular Transferases; C021924:lanosterol synthase