The mechanism of the riboflavin sensitized photodestruction of mitomycin C.
A detailed in vitro study was made of the riboflavin sensitized photodestruction of mitomycin C. The dependences of the quantum yield in the system were examined on the introduction of various amounts of quenchers, such as halogen ion, paramagnetic ion, 1,4-diazabicyclo[2,2,2]octane, 2,6-di-tert-butyl-p-cresol, and p-hydroquinone. The results are consistent with a mechanism involving oxygen molecule in the excited singlet state as the photochemically reactive species. The rate constant of the reaction between the excited singlet oxygen and mitomycin C was calculated to be 8.9 x 10(9) M-1.S-1.
D002413:Cations, Divalent; D007700:Kinetics; D008433:Mathematics; D008937:Mitomycins; D010782:Photolysis; D011789:Quantum Theory; D012256:Riboflavin; D013050:Spectrometry, Fluorescence
D002413:Cations, Divalent; D008937:Mitomycins; D012256:Riboflavin