[Walker's 256 carcinosarcoma: metastatic dissemination in two cell lines (author's transl)].
Walker's 256 carcinosarcoma a transplantable tumor of the rate changes its behaviour as a consequence of various factors. In this paper we compare the evolution of 2 lines of the tumor: WM 16 (muscular) and Christ Hospital (ascitic) both inoculated intramuscularly. Animals receiving line WM 16 had a severe rapidly progressive evolution dying around day 14 after inoculation with diffuse metastases to lymph nodes (65% of animals), kidneys (53%), spleen (50%), lungs (46.5%), liver (45%), bone marrow (44.8%), in 56% of the animals there were circulating tumoral cells. Animals receiving Christ Hospital line survived up to 40 days, metastases were limited do lungs (48.7%) and lymph nodes (31.7%) and only in 2 of 45 animals circulating tumoral cells were observed.
D000818:Animals; D002279:Carcinoma 256, Walker / Q000473:pathology*; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D009362:Neoplasm Metastasis / Q000473:pathology; D051381:Rats; D013045:Species Specificity
Carcino-sarcoma 256 de Walker: disseminação metastática em duas linhagens do tumor.