title: Gentamicin penetration and decay in the human aqueous.
abstract: The penetration of gentamicin into human aqueous was measured after intensive drops or subconjunctival injection of the antibiotic. The drop regimen proved ineffective in producing a therapeutically effective level. After a single 40 mg subconjunctival injection an effective concentration was achieved in 2 hours and maintained for 24 hours. The significance of these findings is discussed with respect to therapeutic implications.
mesh_terms: D000287:Administration, Topical; D000368:Aged; D001082:Aqueous Humor / Q000032:analysis / Q000378:metabolism*; D001702:Biopharmaceutics; D002387:Cataract Extraction; D003228:Conjunctiva; D005260:Female; D005839:Gentamicins / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D007267:Injections; D007700:Kinetics; D008297:Male; D008875:Middle Aged
chemical_list: D005839:Gentamicins