Effect of 2,3-diphosphoglycerate (2,3-DPG) on haemoglobin affinity to oxygen in fetal and early postnatal period of life in pigs.
The reported investigations demonstrated a low concentration of 2,3-DPG in fetal erythrocytes (4.52 mumol/g Hb) and a high affinity of haemoglobin in these erythrocytes to oxygen (P50 = 4.35 mm Hg) as compared with the values in adult pigs (30.91 mumol of 2,3-DPG/g Hb and P50 = 7.36 mm Hg). In the postnatal period the values of these parameters changed rapidly, with the most intense changes taking place within the first three days of life of suckling pigs, and the values typical of adult pigs were reached about the seventh day of life. No differences were observed in the structure of fetal and adult haemoglobin. The affinity to oxygen of haemoglobin solutions obtained from fetuses and adult pigs without 2,3-DPG was identical, and addition of exogenous 2,3-DPG caused indentical shifts of the dissociation curves of both haemoglobins. The factors responsible for the differnces in haemoglobin affinity to oxygen in the development of pigs are changes in the concentration of 2,3-DPG in the erythrocytes.
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D004163:Diphosphoglyceric Acids / Q000494:pharmacology*; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D005333:Fetus / Q000378:metabolism*; D006454:Hemoglobins / Q000378:metabolism; D010100:Oxygen / Q000097:blood*; D011247:Pregnancy; D013552:Swine / Q000097:blood*
D004163:Diphosphoglyceric Acids; D006454:Hemoglobins; D010100:Oxygen