Anti-idiotypic antibodies of IgM-type produced in carp (Cyprinus carpio L.).
Carp synthesize highly specific anti-idiotypic antibodies of the IgM class. Ant-idiotypic antibodies could be elicited in these animals by a human IgM myeloma protein and were detected in a passive hemagglutination assay. The agglutination was completely inhibited by approximately 0.15 microgram homologous antigen, whereas a 100 000-fold excess of a heterologous IgM myeloma protein of the same L chain type did not produce any inhibition. A possible subgroup specificity of carp anti-idiotypic antisera can be excluded.
D000818:Animals; D000918:Antibody Specificity; D002347:Carps; D006041:Goats; D006385:Hemagglutination Inhibition Tests; D006386:Hemagglutination Tests; D006801:Humans; D007106:Immune Sera / Q000302:isolation & purification; D007074:Immunoglobulin G / Q000276:immunology; D007130:Immunoglobulin Idiotypes; D007075:Immunoglobulin M / Q000276:immunology*; D010265:Paraproteinemias / Q000276:immunology; D012756:Sheep
D007106:Immune Sera; D007074:Immunoglobulin G; D007130:Immunoglobulin Idiotypes; D007075:Immunoglobulin M