[Toxicity and radioprotective properties of 1,3-oxazine and 1,3-thiazine derivatives].
Toxicity and radioprotective properties of 18 derivatives of oxazine and thiazine with a varying degree of the cycle saturation were studied in experiments on mice. Monotypic regularity in variations of their toxic properties relative to the chemical structure was noted. 4,4,6-Trimethyl-2-dimethylamino-4H-1,3-oxazine exerted a pronounced radioprotective action.
D000818:Animals; D005720:Gamma Rays; D007274:Injections, Intraperitoneal; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010078:Oxazines / Q000633:toxicity*; D011837:Radiation-Protective Agents; D013329:Structure-Activity Relationship; D013843:Thiazines / Q000633:toxicity*
D010078:Oxazines; D011837:Radiation-Protective Agents; D013843:Thiazines
Toksichnost' i radiozashchitnye svoĭstva proizvodnykh 1,3-oksazina i 1,3-tiazina.