title: Cerebrospinal fluid pulse pressure and intracranial volume-pressure relationships.
abstract: In six anaesthetised and ventilated dogs the CSF pulse pressure was compared with the volume-pressure response (VPR) during continuous inflation of an extradural balloon. Both pulse pressure and VPR increased linearly with the ventricular fluid pressure (VFP) up to a mean VFP of 60 mmHg. At this pressure a breakpoint occurred above which the CSF pulse pressure showed a steeper linear increase, while the VPR remained constant. It is suggested that the breakpoint is related to failure of autoregulation, and that in non-autoregulating patients the CSF pulse pressure is a better parameter of the clinical state than the VPR.
mesh_terms: D000818:Animals; D001794:Blood Pressure; D001810:Blood Volume; D002245:Carbon Dioxide / Q000097:blood; D002552:Cerebral Ventricles / Q000502:physiology; D002560:Cerebrovascular Circulation; D004285:Dogs; D005260:Female; D006706:Homeostasis; D007427:Intracranial Pressure; D008297:Male; D010477:Perfusion; D011674:Pulse
chemical_list: D002245:Carbon Dioxide