[Electrophysiologic study of the properties of the cholinoreceptors of frog sympathetic ganglion neurons].
The effect of the perfusion with cholinomimetics and cholinolytics on the membrane potential and membrane conduction of the isolated frog sympathetic ganglion neurons was studied using the intracellular microelectrodes. The activation of nicotinic cholinoreceptors with carbachol, suberildicholine and tetramethylammonium evoked depolarization with an increase in membrane conduction. The activation of muscarinic receptors with carbachol and 5-methylfurmethide evoked depolarization accompanied with a decrease or less frequently with an increase in the membrane conduction. It is found that atropine caused no changes in the membrane electric parameters when used as the perfused first drug, but it caused a short-lasting depolarization with the membrane conduction increase when used after carbachol.
D000818:Animals; D001001:Anura; D001285:Atropine / Q000494:pharmacology; D002217:Carbachol / Q000494:pharmacology; D005728:Ganglia, Sympathetic / Q000187:drug effects*; D008564:Membrane Potentials / Q000187:drug effects; D010276:Parasympatholytics / Q000494:pharmacology*; D010277:Parasympathomimetics / Q000494:pharmacology*; D011898:Ranidae; D011950:Receptors, Cholinergic / Q000187:drug effects*; D011976:Receptors, Muscarinic / Q000187:drug effects*; D011978:Receptors, Nicotinic / Q000187:drug effects*
D010276:Parasympatholytics; D010277:Parasympathomimetics; D011950:Receptors, Cholinergic; D011976:Receptors, Muscarinic; D011978:Receptors, Nicotinic; D001285:Atropine; D002217:Carbachol
Elektrofiziologicheskoe issledovanie svoĭstv kholinoretseptorov neĭronov simpaticheskikh gangliev liagushki.