[The effect of aldosterone antagonists in juvenile heart surgery].
In children with congenital heart disease duration and extent of hyperaldosteronism and the influence of spironolactone after surgery with a heart-lung-machine, were evaluated by direct measurement of plasma aldosterone levels. Secondary hyperaldosteronism as seen in 11 patients without spironolactone-therapy after surgery did not persist very long. 14 children receiving spironolactone immediately after surgery showed an onset of drug efficacy at a period when plasma aldosterone in the group without spironolactone had begun to fall. As a practical consequence, spironolactone treatment should be initiated a few days prior to surgery in order to achieve full efficacy on the day of surgery.
D000293:Adolescent; D002315:Cardiopulmonary Bypass; D002648:Child; D002675:Child, Preschool; D004334:Drug Administration Schedule; D006330:Heart Defects, Congenital / Q000150:complications / Q000601:surgery*; D006801:Humans; D006929:Hyperaldosteronism / Q000188:drug therapy* / Q000209:etiology; D013148:Spironolactone / Q000627:therapeutic use*
D013148:Spironolactone
Die Wirksamkeit von Aldosteronantagonisten bei herzchirurgischen Operationen im Kindesalter.