Effective iron chelation following oral administration of an isoniazid-pyridoxal hydrazone.
When isoniazid and pyridoxal are mixed in equimolar quantities a hydrazone is formed which is able to complex with iron. The oral administration of this compound to rats in single doses of 25--100 mg/kg leads to an increase in faecal iron excretion up to 8 times the normal level. In tissue culture the compound is able to remove iron from Chang cells. The results suggest that this compound may be of potential value for the oral therapy of iron overload.
D000818:Animals; D003676:Deferoxamine / Q000494:pharmacology; D006418:Heme / Q000378:metabolism; D007501:Iron / Q000378:metabolism / Q000652:urine; D007502:Iron Chelating Agents / Q000008:administration & dosage*; D007538:Isoniazid / Q000008:administration & dosage* / Q000494:pharmacology; D008099:Liver / Q000378:metabolism; D008297:Male; D011730:Pyridoxal / Q000008:administration & dosage* / Q000494:pharmacology; D011736:Pyridoxine / Q000494:pharmacology; D051381:Rats; D013154:Spleen / Q000378:metabolism
D007502:Iron Chelating Agents; D011730:Pyridoxal; D006418:Heme; D007501:Iron; D003676:Deferoxamine; D011736:Pyridoxine; D007538:Isoniazid