title: Pituitary adenomas. Clinico-morphologic correlations.
abstract: Immunohistochemistry and electron microscopy allow new insights into the biology and natural history of the proliferative processes of the hypophysis. Hyperplasia can be diffuse or focal. Its function and/or growth are controlled by hypothalamic factors. Hyperplasia may precede the formation of an adenoma. Function and/or growth of adenomas is partially or completely independent of hypothalamic regulation. Adenomas are divided according to their functional activity into an endocrine active and inactive group. A further subdivision is made according to the secreted hormone. Inactive adenomas may have lost the ability to produce hormones, may secrete hormones at a very low rate, or may secrete abnormal substances.
mesh_terms: D000236:Adenoma / Q000473:pathology* / Q000648:ultrastructure; D000328:Adult; D005260:Female; D006801:Humans; D006965:Hyperplasia; D010902:Pituitary Gland / Q000473:pathology; D010911:Pituitary Neoplasms / Q000473:pathology* / Q000648:ultrastructure; D011388:Prolactin / Q000378:metabolism
chemical_list: D011388:Prolactin