Urinary pregnanetriol and delta 5-pregnentriol in women with idiopathic hirsutism.
Urinary pregnanetriol and delta 5-pregnenetriol were determined in 90 normal women and in 90 women with idiopathic hirsutism of comparable age group. When group Student's "t"-test was carried out, the mean steroid excretion values in hirsute women were found to be significant with delta 5-pregnenetriol more significant than pregnanetriol. Of the 90 women with hirsutism, 8 patients had pregnanetriol and delta 5-pregnenetriol values higher than normal. When, on the basis of these elevated values, the women were sent for a thorough gynaecological investigation, they were found to have the polycystic ovary syndrome. After wedge resection, the diagnosis was confirmed and the urinary excretion of pregnanetriol and delta 5-pregnenetriol came down to a normal level. This study shows that, in the case of women with idiopathic hirsutism suspected of any ovarian disorder, the measurement of these two steroids could be of diagnostic importance.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D005260:Female; D006628:Hirsutism / Q000652:urine*; D006801:Humans; D008875:Middle Aged; D011279:Pregnanetriol / Q000652:urine*; D011283:Pregnenes / Q000652:urine*; D012016:Reference Values
D011283:Pregnenes; D011279:Pregnanetriol; C026087:5-pregnene-3 beta,17 alpha,20 alpha-triol