Effects of fibroblast growth factor and bromocriptine on the mitotic activity of the anterior pituitary gland in organ culture.
Effects of fibroblast growth factor (FGF) and of bromocriptine, a dopaminergic receptor agonist, on the mitotic index in the organ-cultured anterior pituitary gland of the rat were investigated, using the colchicine metaphase-arrest technique. It has been found that FGF increases the mitotic index in the anterior pituitary explants. By contrast bromocriptine inhibits the mitogenic effect of FGF.
D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology*; D005246:Feedback; D005347:Fibroblasts / Q000378:metabolism*; D006131:Growth Inhibitors; D006133:Growth Substances / Q000494:pharmacology*; D008297:Male; D008934:Mitogens; D008938:Mitosis / Q000187:drug effects*; D009924:Organ Culture Techniques; D010903:Pituitary Gland, Anterior / Q000166:cytology / Q000187:drug effects*; D051381:Rats
D006131:Growth Inhibitors; D006133:Growth Substances; D008934:Mitogens; D001971:Bromocriptine