title: [Critical remarks on the investigation methods of coergistic effects of acute oral toxicity of combination insecticides].
abstract: Often the application of fractions of the LD50 (e.g. 1/4 LD50, 1/2 LD50) is unavoidable due to technical conditions in the experiment (e.g. in case of substances with low toxicity and in case of very steep slope functions). But if ever possible, dosage of equitoxic amounts (LD10, LD50 etc.) should be prefered, because of higher reliability in the choice of dosage and evaluation of the results. Benefits and disadvantages of the two experimental principles are demonstrated by results of own investigations.
mesh_terms: D000818:Animals; D004336:Drug Antagonism; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004357:Drug Synergism; D005260:Female; D006540:Herbicides / Q000633:toxicity*; D007306:Insecticides / Q000633:toxicity*; D007928:Lethal Dose 50; D008297:Male
chemical_list: D004338:Drug Combinations; D006540:Herbicides; D007306:Insecticides
vernacular_title: Kritische Betrachtungen zur Methodik des Erfassens koergistischer Effekte der akuten oralen Toxizität kombinierter Pflanzenschutzmittel.