[Role of glucocorticoids in the mitochondrial DNA replication].
The liver mitochondrial DNA biosynthesis was found to be enhanced in adrenalectomized rats. Cortisol administration to adrenalectomized rats caused a decrease of the liver mitochondrial DNA biosynthesis. Sedimentation analysis of the mitochondrial DNA in CsCl--EtBr gradient has demonstrated that 3H-thymidine incorporation into the mictochondrial DNA increased mainly in the "open circular" molecules fraction.
D000315:Adrenalectomy; D000818:Animals; D004261:DNA Replication / Q000187:drug effects*; D004272:DNA, Mitochondrial / Q000096:biosynthesis*; D005938:Glucocorticoids / Q000494:pharmacology; D006854:Hydrocortisone / Q000494:pharmacology*; D066298:In Vitro Techniques; D007553:Isotope Labeling; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism*; D051381:Rats; D014316:Tritium
D004272:DNA, Mitochondrial; D005938:Glucocorticoids; D014316:Tritium; D006854:Hydrocortisone
Rol' gliukokortikoidnykh gormonov v replikatsii mitokhondrial'nykh DNK.