A correlation between estrogen sulfotransferase levels and estrogen receptor status in human primary breast carcinoma.
Estrogen sulfotransferase (EC 2.8.2.4) activity and estrogen receptor levels were measured in 32 human primary breast cancer cytosol preparations. Two types of tumors were identified: type 1, in which estrogen sulfotransferase levels were low (less than 40 pmol 17 beta-estradiol 3-sulfate formed per mg protein per 2 hr) and were independent of [35S]adenosine 3'-phosphate 5'-phosphosulfate production from [35S]sulfate and adenosine triphosphate, and type 2, in which estrogen sulfotransferase levels ranged from 50 to 200 pmol 17 beta-estradiol 3-sulfate per mg protein per 2 hr and were correlated with [35S]adenosine 3'-phosphate 5'-phosphosulfate formation (r = 0.70; p less than 0.005). In type 1 tumors, 11 of 16 were estrogen receptor negative; in type 2 tumors, 2 of 16 were receptor negative. Estrogen sulfotransferase levels in receptor-negative tumors were significantly lower than the levels in receptor-positive tumors (p = 0.025).
D001943:Breast Neoplasms / Q000378:metabolism*; D003600:Cytosol / Q000378:metabolism; D004967:Estrogens / Q000378:metabolism*; D004970:Estrone; D005260:Female; D006801:Humans; D009376:Neoplasms, Hormone-Dependent / Q000378:metabolism*; D010724:Phosphoadenosine Phosphosulfate / Q000096:biosynthesis; D011960:Receptors, Estrogen; D015238:Sulfotransferases; D013466:Sulfurtransferases / Q000378:metabolism*
D004967:Estrogens; D011960:Receptors, Estrogen; D004970:Estrone; D010724:Phosphoadenosine Phosphosulfate; D013466:Sulfurtransferases; D015238:Sulfotransferases; C020122:estrone sulfotransferase