The pharmacological relevance of vital staining with neutral red.
The uptake of neutral red into the renin-containing juxtaglomerular granules does not inhibit the release of renin either in basal or in stimulated states of renin secretion. The vasodilating effect of neutral red may be due to a nonspecific binding to noradrenaline-receptors in the vascular smooth muscle cells.
D000804:Angiotensin II / Q000097:blood; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D007606:Juxtaglomerular Apparatus / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D009499:Neutral Red / Q000494:pharmacology*; D009638:Norepinephrine / Q000494:pharmacology; D010619:Phenazines / Q000494:pharmacology*; D051381:Rats; D012083:Renin / Q000378:metabolism*
D010619:Phenazines; D000804:Angiotensin II; D009499:Neutral Red; D012083:Renin; D009638:Norepinephrine