Antitumor anthracycline antibiotics, aclacinomycin A and analogues. I. Taxonomy, production, isolation and physicochemical properties.
Aclacinomycin A and B, two major components of a new antitumor antibiotic complex, and their 19 analogues were produced by a culture of strain No. MA144-M1, which was identified as Streptomyces galilaeus. They were isolated by chelation with copper ion and silicic acid chromatography, and characterized by physicochemical methods in the anthracycline group of antibiotics.
D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005285:Fermentation; D009279:Naphthacenes / Q000096:biosynthesis; D013302:Streptomyces / Q000145:classification / Q000378:metabolism
D000903:Antibiotics, Antineoplastic; D009279:Naphthacenes