Growth retardation in rat fetuses induced by chlorpromazine hydrochloride (CPZ).
Maternal administration of 100 mg/kg of chlorpromazine hydrochloride on 14th gestation day led to a significant (P less than 0.001) intrauterine growth retardation (IUGR) in rat fetuses collected from 16th--20th days of gestation. Besides weight of the fetus, other measurements were used to assess the stunted growth, e.g. CR length, tail length and trans-umbilical distance (TUD). The latter was as efficacious as the weight since with each one of them the IUGR was found in 88% of fetuses at--2SD level on 20th day of gestation. The different components of the fetal environments, e.g. weight and volume of placenta, length of the umbilical cord, weight and volume of amniotic fluid were also investigated which showed a positive correlation between alteration in the fetal environment and IUGR.
D000653:Amniotic Fluid / Q000187:drug effects; D000818:Animals; D002746:Chlorpromazine / Q000009:adverse effects* / Q000494:pharmacology; D005260:Female; D005317:Fetal Growth Retardation / Q000139:chemically induced*; D005865:Gestational Age; D008431:Maternal-Fetal Exchange; D010920:Placenta / Q000187:drug effects; D011247:Pregnancy; D051381:Rats; D014470:Umbilical Cord / Q000187:drug effects
D002746:Chlorpromazine