title: Has cimetidine revolutionised the medical treatment of peptic ulceration?
abstract: Cimetidine inhibits gastric-acid secretion, whatever the stimulant. It is superior to placebo for the healing of both duodenal and gastric ulceration, but it does not cure peptic ulceration. When the drug is stopped ulcers often return. Maintenance treatment with cimetidine taken only at bedtime eliminates duodenal ulcer recurrence in most patients.
mesh_terms: D002927:Cimetidine / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D004381:Duodenal Ulcer / Q000188:drug therapy*; D005750:Gastric Juice / Q000378:metabolism; D006146:Guanidines / Q000627:therapeutic use*; D006801:Humans; D013276:Stomach Ulcer / Q000188:drug therapy*
chemical_list: D006146:Guanidines; D002927:Cimetidine