Discontinuous absorption processes in pharmacokinetic models.
The limited contact time of absorbable drug with absorbing surfaces is, in some cases, a significant factor determining the fraction of the dose absorbed. A simple modification of customary linear compartmental models is presented to account for this situation, and a general input function in the Laplace domain for truncated first-order absorption is derived. An extension to series of truncated absorption processes is discussed.
D000042:Absorption; D002026:Buformin / Q000378:metabolism; D006118:Griseofulvin / Q000378:metabolism; D007408:Intestinal Absorption; D007700:Kinetics; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D013444:Sulfisoxazole / Q000378:metabolism; D013997:Time Factors
D004364:Pharmaceutical Preparations; D006118:Griseofulvin; D013444:Sulfisoxazole; D002026:Buformin