Effect of infusion of dextran 70 on fibrinolysis inhibition activity in human serum.
The effect of dextran on fibrinolysis inhibition activity was studied in the serum of normal (uninjured) persons and of post-traumatic patients. An intravenous infusion of 500 ml dextran 70 significantly decreased the fibrinolysis inhibition activity in the serum in both groups. The decrease was greater in the trauma group. Treatment with dextran in the post-traumatic phase may therefore diminish the risk of development of complication due to thromboembolism.
D000293:Adolescent; D000328:Adult; D000368:Aged; D003911:Dextrans / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D005340:Fibrinogen / Q000032:analysis; D005342:Fibrinolysis / Q000187:drug effects*; D050723:Fractures, Bone / Q000150:complications / Q000188:drug therapy; D006801:Humans; D007263:Infusions, Parenteral; D008875:Middle Aged; D010958:Plasminogen / Q000032:analysis; D013923:Thromboembolism / Q000209:etiology / Q000517:prevention & control; D014148:Tranexamic Acid / Q000494:pharmacology
D003911:Dextrans; D014148:Tranexamic Acid; D005340:Fibrinogen; D010958:Plasminogen