Diesters of 4,4'-(piperazine1,4-diyl)bis-4-oxo 2-butenoic acid.
The title compounds were prepared by acylation of piperazine with maleic acid ester chlorides in methylene chloride medium in the presence of K2CO3. In preliminary screening some of them showed marked antimitotic activity on plant materials.
D000215:Acylation; D002087:Butyrates / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D003437:Crotonates / Q000138:chemical synthesis* / Q000494:pharmacology; D008938:Mitosis / Q000187:drug effects; D010879:Piperazines / Q000138:chemical synthesis* / Q000494:pharmacology; D010944:Plants
D002087:Butyrates; D003437:Crotonates; D010879:Piperazines