title: Clearance by the mucociliary system in 'simple chronic otitis media'.
abstract: This is a study of the rate of middle ear clearance in chronic otitis media and atelectatic ears. The clearance rate was measured with the aid of non-soluble saccharin, introduced into the middle ear through an existing perforation in 'chronic ears', or through a ventilating tube in atelectatic ears. Cholesteatomatous ears were excluded. Altogether 122 ears were examined and about two-thirds of the subjects felt the sweet taste in their mouths thereafter. The average time it took for the saccharin to be transported from the middle ear to the taste buds was 33' 22" minutes in non-infected (i.e. dry) chronic ears (38 patients or 66 per cent). Wet or infected ears with chronic otitis media (30 patients, or 58 per cent) showed a slower transport rate, averaging 54' 22" minutes--the difference was significant at the 0.01 level. 8 (63 per cent) of the atelectatic ears transported the saccharin at an average rate of 50' 25". This study demonstrated that most ears with 'simple' chronic otitis media and atelectatic ears have a patent eustachian tube and that their mucociliary system can transport foreign particles through it. When the ear is infected, transport tends to be slowed down.
mesh_terms: D002908:Chronic Disease; D002923:Cilia / Q000502:physiology; D004432:Ear, Middle / Q000502:physiology / Q000503:physiopathology*; D006801:Humans; D009092:Mucous Membrane / Q000502:physiology; D010033:Otitis Media / Q000503:physiopathology*; D010035:Otitis Media, Suppurative / Q000503:physiopathology; D012439:Saccharin
chemical_list: D012439:Saccharin