[Mechanism of regulation of steroidogenesis in the adrenals by blood serum lipoproteins].
It has been shown that high density lipoproteins obtained by ultracentrifugation and loaded with cholesterol and pregnenolone exert a stimulant effect on in vitro production of glucocorticoids by rat adrenals. Low density native lipoproteins possess an inhibitory effect connected with the protein component. The action of various blood serum lipoproteins on steroidogenesis in rat adrenals has significantly different mechanisms.
D000311:Adrenal Glands / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D002784:Cholesterol / Q000494:pharmacology; D005938:Glucocorticoids / Q000096:biosynthesis*; D008074:Lipoproteins / Q000097:blood / Q000494:pharmacology*; D008297:Male; D011284:Pregnenolone / Q000494:pharmacology; D051381:Rats
D005938:Glucocorticoids; D008074:Lipoproteins; D011284:Pregnenolone; D002784:Cholesterol
Mekhanizm reguliatsii steroidogeneza v nadpochechnikakh lipoproteidami syvorotki krovi.