Effects of metal ions and selenoamino acids on induction of glutathione peroxidase in mouse neuroblastoma.
The induction of glutathione peroxidase in mouse neuroblastoma cells by selenite is enhanced by equimolar amounts of arsenate, arsenite, molybdate, chromic or dichromate ions. At equimolar selenium concentration, selenite, selenocystine and selenomethionine induced glutathione peroxidase activities having the ratios 4:4:1. Protein synthesis inhibitors prevented the induction of glutathione peroxidase by selenite indicating that de novo protein synthesis is required.
D000818:Animals; D001149:Arsenates / Q000494:pharmacology; D002478:Cells, Cultured; D002840:Chromates / Q000494:pharmacology; D003553:Cystine / Q000031:analogs & derivatives / Q000494:pharmacology; D004790:Enzyme Induction / Q000187:drug effects; D005979:Glutathione Peroxidase / Q000096:biosynthesis*; D051379:Mice; D008982:Molybdenum / Q000494:pharmacology; D009447:Neuroblastoma / Q000201:enzymology*; D016566:Organoselenium Compounds; D010544:Peroxidases / Q000096:biosynthesis*; D012643:Selenium / Q000494:pharmacology*; D012645:Selenomethionine / Q000494:pharmacology*
D001149:Arsenates; D002840:Chromates; D016566:Organoselenium Compounds; C009226:selenocystine; D003553:Cystine; D008982:Molybdenum; D012645:Selenomethionine; D010544:Peroxidases; D005979:Glutathione Peroxidase; D012643:Selenium