title: pKa values of estrone, 17 beta-estradiol and 2-methoxyestrone.
abstract: The acid ionization constants of estrone (10.77), 17 beta-estradiol (10.71) and 2-methoxyestrone (10.81) have been determined spectrophotometrically and shown to be consistent with the additivity of substituent effects of the phenol ring. Previously published values for estrone (10.914) and 17 beta-estradiol (10.078) are shown to be incorrect, at variance with the established trend for phenols, and inconcsistent with the similarity of the compounds.
mesh_terms: D004958:Estradiol; D004970:Estrone / Q000031:analogs & derivatives; D006894:Hydroxyestrones; D007477:Ions; D013056:Spectrophotometry, Ultraviolet
chemical_list: D006894:Hydroxyestrones; D007477:Ions; D004970:Estrone; D004958:Estradiol; C003655:2-methoxyestrone