Detection of CNS-depressant properties of antihypertensives: validity of various test methods in rodents and estimation of therapeutic margin in hypertensive rats.
D000777:Anesthetics / Q000494:pharmacology; D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000633:toxicity*; D001522:Behavior, Animal / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D002492:Central Nervous System Depressants; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005106:Exploratory Behavior / Q000187:drug effects; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010642:Phenoxyacetates / Q000494:pharmacology; D051381:Rats
D000777:Anesthetics; D000959:Antihypertensive Agents; D002492:Central Nervous System Depressants; D010642:Phenoxyacetates