Effect of human chorionic gonadotrophin on phagocytic activity and proliferative capacity of rat peritoneal macrophages in culture.
Human chorionic gonadotrophic hormone (hCG) decreased phagocytosis of rat peritoneal macrophages in culture and also inhibited their capacity to be stimulated by an inflammatory exudate. Both effects were related to the concentration used. These experimental results suggest that elevated levels of hCG may play a role in the prevention of the rejection of the foetal allograft by the maternal host.
D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology; D002455:Cell Division / Q000187:drug effects*; D002478:Cells, Cultured; D006063:Chorionic Gonadotropin / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis; D005122:Exudates and Transudates; D007249:Inflammation; D008264:Macrophages / Q000187:drug effects*; D010587:Phagocytosis / Q000187:drug effects*; D051381:Rats
D006063:Chorionic Gonadotropin; D004247:DNA