Nephrotic syndrome in anti-GBM antibody mediated glomerulonephritis.
Glomerulonephritis induced by antibodies to the glomerular basement membrane is a well recognized cause of renal disease and is responsible for 5% to 15% of all glomerular disease. The patients usually present with an acute nephritic syndrome followed by rapidly progressive renal failure. We report two patients who presented with the nephrotic syndrome and anti-GBM glomerulonephritis, and who exhibited differing clinical courses not characteristic of "rapidly progressive glomerulonephritis" or Goodpasture's syndrome.
D000328:Adult; D019867:Anti-Glomerular Basement Membrane Disease / Q000150:complications; D000906:Antibodies; D001485:Basement Membrane / Q000276:immunology / Q000473:pathology*; D005921:Glomerulonephritis / Q000150:complications* / Q000276:immunology / Q000473:pathology; D006801:Humans; D007678:Kidney Glomerulus / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000209:etiology*
D000906:Antibodies