Does exposure to elevated levels of lead enhance sodium induced hypertension?
Numerous community drinking water sources have elevated levels of both sodium and lead. Recently reported studies have indicated that elevated levels of sodium in drinking water may be a facter in the development of elevated blood pressure. The question of how elevated levels of lead may affect sodium induced elevated blood pressure is addressed. The hypothesis is developed which states that elevated levels of lead exposure will not interact with sodium to enhance the development of renin angiotensin aldosterone related hypertension but in fact may even diminish the effects of exposure to elevated amounts of sodium on blood pressure through a depression of plasma renin activity.
D000818:Animals; D004357:Drug Synergism; D006801:Humans; D006973:Hypertension / Q000139:chemically induced*; D007854:Lead / Q000009:adverse effects* / Q000032:analysis / Q000378:metabolism; D051381:Rats; D012083:Renin / Q000097:blood; D012964:Sodium / Q000009:adverse effects* / Q000032:analysis / Q000378:metabolism; D014877:Water Pollution, Chemical / Q000032:analysis
D007854:Lead; D012964:Sodium; D012083:Renin