Oxyphenisatin derivatives and intestinal glucose and tyrosine absorption.
The effect of oxyphenisatin and three other isatin derivatives on glucose and tyrosine absorption is studied in rat small intestine, in vitro. Compounds with free phenolic groups elicit, even at low concentrations, strong inhibition on active transport, while those with the sulfate-esterified phenolic groups show no effect whatsoever. One minute preincubation with 10(-7) M oxyphenisatin is enough to inhibit sugar absorption completely.
D005947:Glucose / Q000378:metabolism*; D006003:Glycogen / Q000096:biosynthesis; D006801:Humans; D007328:Insulin / Q000494:pharmacology*; D007408:Intestinal Absorption; D008214:Lymphocytes / Q000378:metabolism*; D014280:Triglycerides / Q000096:biosynthesis
D007328:Insulin; D014280:Triglycerides; D006003:Glycogen; D005947:Glucose