title: The effect of acetyl salicylic acid and dipyridamole on thromboembolic complications in splenectomized patients with myelofibrosis.
abstract: The effect of combined treatment with acetyl salicylic acid and dipyridamole on thrombic phenomena was studied in splenectomized patients with an aggressive form of myelofibrosis. 3 of these patients had thrombotic episodes, shortened platelet survival and an abnormal platelet aggregation pattern. The treatment with antiplatelet drugs resulted in a decreased platelet utilization as evidenced by clinical improvement and an increasing platelet concentration.
mesh_terms: D000368:Aged; D001241:Aspirin / Q000008:administration & dosage* / Q000627:therapeutic use; D001792:Blood Platelets; D002470:Cell Survival / Q000187:drug effects; D004176:Dipyridamole / Q000008:administration & dosage* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010960:Plasminogen Activators / Q000378:metabolism; D010974:Platelet Aggregation / Q000187:drug effects; D055728:Primary Myelofibrosis / Q000188:drug therapy*; D013156:Splenectomy; D013923:Thromboembolism / Q000150:complications / Q000188:drug therapy*
chemical_list: D004176:Dipyridamole; D010960:Plasminogen Activators; D001241:Aspirin