Regional mapping of the gene for human UDPGal 4-epimerase on chromosome 1 in mouse-human hybrids.
Somatic cell hybrids between mouse and human cells containing two different reciprocal translocations involving human chromosome 1, 46,X,t(1;X)(q12;q26) and 47,XX,+21,t(1;17)(p32;p13), were studied for the expression of human uridine diphosphate galactose 4-epimerase (UDPGal 4-epimerase, E.C. 5.1.3.2) by starch-gel electrophoresis. Analysis of the hybrid clones for the expression of the enzyme and the presence of the translocation chromosome 1 has permitted the assignment of the gene for human UDPGal 4-epimerase to the pter yields p32 region of chromosome 1.
D000818:Animals; D002238:Carbohydrate Epimerases / Q000235:genetics*; D002460:Cell Line; D002874:Chromosome Mapping; D002900:Chromosomes, Human, 1-3 / Q000201:enzymology*; D002999:Clone Cells / Q000201:enzymology / Q000648:ultrastructure; D004592:Electrophoresis, Starch Gel; D005347:Fibroblasts; D006168:Guinea Pigs; D006801:Humans; D006822:Hybrid Cells / Q000201:enzymology / Q000648:ultrastructure*; D012867:Skin; D014178:Translocation, Genetic; D014534:UDPglucose 4-Epimerase / Q000235:genetics*
D002238:Carbohydrate Epimerases; D014534:UDPglucose 4-Epimerase