The uptake of methyl mercury in guinea pig cochlea in relation to its ototoxic effect.
Guinea pigs were treated for 7 days by daily subcutaneous injection of methyl mercury chloride labeled with 14C, the total dose of which was 17 mg Hg/kg. In these animals the cochlear microphonics and whole-nerve action potentials were suppressed in the basal turn but there was no marked losses in the third turn of the cochlea. The endocochlear potential was not decreased in magnitude. At the end of the treatment there was no accumulation of mercury in the perilymph, endolymph and cerebrospinal fluid. Uptake and elimination of mercury in the cochlear fluids were studied in guinea pigs which were treated by a single intravenous injection of 203Hg-labeled methyl mercury, the dose of which ranged from 0.2 to 17 mg Hg/kg. The results indicated that mercury concentration ratio of the blood relative to cochlear fluids was comparable with the blood to plasma ratio reported previously. In contrast to lack of accumulation in the extra cellular environment, it is likely that tissues of the sensory end organs in the cochlea accumulated methyl mercury.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D003051:Cochlea / Q000187:drug effects / Q000378:metabolism*; D004710:Endolymph / Q000378:metabolism; D006168:Guinea Pigs; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D008564:Membrane Potentials / Q000187:drug effects; D008767:Methylmercury Compounds / Q000008:administration & dosage / Q000378:metabolism* / Q000494:pharmacology; D010498:Perilymph / Q000378:metabolism
D008767:Methylmercury Compounds