Increase in the preneoplastic liver lesions by thioacetamide followed by repeated partial hepatectomy.
Thioacetamide administration at low dose induces minimal changes in rat liver. Following withdrawal of the drug, the extent of the subsequent cholangiofibrosis and hyperplastic hepatocyte proliferation is strongly enhanced by partial hepatectomies performed monthly on the same animal.
D000081:Acetamides / Q000008:administration & dosage; D000818:Animals; D002455:Cell Division; D006498:Hepatectomy; D008099:Liver / Q000187:drug effects*; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000503:physiopathology; D008115:Liver Regeneration; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced; D011230:Precancerous Conditions / Q000139:chemically induced* / Q000503:physiopathology; D051381:Rats; D013853:Thioacetamide / Q000008:administration & dosage; D013997:Time Factors
D000081:Acetamides; D013853:Thioacetamide