title: Genetics, ontogeny, and testosterone inducibility of aldehyde oxidase isozymes in the mouse: evidence for two genetic loci (Aox-I and Aox-2) closely linked on chromosome 1.
abstract: "Null"-activity and low-activity variants for the liver supernatant isozymes of aldehyde oxidase (designated AOX-1 and AOX-2) were observed in inbred strains and in Harwell linkage testing stocks of Mus musculus. The genetic loci determining the activity of these isozymes (designated Aox-1 and Aox-2, respecitively) are closely linked on chromosome 1 near Id-1 (encoding the soluble isozyme of isocitrate dehydrogenase). Linkage data of Aox-1 with Id-1 and Dip-1 (encoding a kidney peptidase) demonstrated that this gene coincides with or is closely linked to Aox (Watson et al., 1972). Ontogenetic analyses demonstrated that liver AOX-1 appeared just before birth and increased in activity during postnatal development, whereas liver AOX-2 was observed only during postnatal development. Adult male livers exhibited higher AOX-1 and AOX-2 activities than adult female livers. Both isozymes were significantly reduced in activity by castration of adult males and increased following testosterone administration to castrated males and normal female mice.
mesh_terms: D000429:Alcohol Oxidoreductases / Q000096:biosynthesis; D000445:Aldehyde Oxidoreductases / Q000235:genetics*; D000818:Animals; D002874:Chromosome Mapping; D004790:Enzyme Induction; D005260:Female; D005796:Genes; D007527:Isoenzymes / Q000235:genetics*; D008099:Liver / Q000196:embryology / Q000201:enzymology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000196:embryology / Q000235:genetics*; D012737:Sex Factors; D013739:Testosterone / Q000494:pharmacology
chemical_list: D007527:Isoenzymes; D013739:Testosterone; D000429:Alcohol Oxidoreductases; D000445:Aldehyde Oxidoreductases