[Cytogenic analysis in HBsAg positive subjects, healthy carriers and patients with acute-phase hepatitis].
A highly significant incidence, ranging from 3% to 20% of chromosomal stickiness and agglutination, has been found in 100% of patients with viral hepatitis HBsAg positive and, in lower grade, in carriers of HBsAg. Whereas, such a structural aberration does not occur in normal subjects. No statistical difference has been found as regard chromosomal fragmentation, presence of incisures and numerical anomalies. A possible role of the observed alterations for an impaired cellular immune function observed in healthy HBsAg carriers has been discussed.
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D002353:Carrier State / Q000276:immunology*; D002842:Chromatids / Q000276:immunology; D002869:Chromosome Aberrations; D005260:Female; D006509:Hepatitis B / Q000235:genetics*; D006514:Hepatitis B Surface Antigens / Q000302:isolation & purification*; D006801:Humans; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged
D006514:Hepatitis B Surface Antigens
Analisi citogenetica in soggetti HBsAg positivi, portatori sani ed epatitici in fase acuta.