Has droperidol an atropinic effect?
The action of droperidol on the tachycardia produced by atropine and on the serum concentration of cholinesterases was observed during balanced anaesthesia. Without atropine, the mean heart rates of patients who received fentanyl plus droperidol were similar. Atropine increased heart rate only in the presence of droperidol (P less than 0.001) (fentanyl v. fentanyl plus droperidol: P less than 0.05). Droperidol inhibited serum cholinesterases (P less than 0.05); this effect was independent of atropine.
D000328:Adult; D001285:Atropine / Q000494:pharmacology*; D002802:Cholinesterases / Q000097:blood; D004329:Droperidol / Q000494:pharmacology*; D004357:Drug Synergism; D005260:Female; D005283:Fentanyl / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008297:Male; D011897:Random Allocation; D013268:Stimulation, Chemical
D001285:Atropine; D002802:Cholinesterases; D004329:Droperidol; D005283:Fentanyl