Efficacy of avermectin B1a against microfilariae of Dirofilaria immitis.
Avermectin B1a given at a dose level of 0.05 or 0.1 mg/kg of body weight caused rapid removal of Dirofilaria immitis microfilariae from the blood of dogs with heartworm infections. If the adult worms were also killed with an arsenical (melarsoprol), the removal of microfilariae was permanent.
D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D001769:Blood / Q000469:parasitology; D004184:Dirofilariasis / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D004187:Disaccharides / Q000627:therapeutic use; D004283:Dog Diseases / Q000188:drug therapy* / Q000469:parasitology; D004285:Dogs; D007559:Ivermectin / Q000031:analogs & derivatives; D007783:Lactones / Q000627:therapeutic use*; D008842:Microfilariae
D000871:Anthelmintics; D004187:Disaccharides; D007783:Lactones; D007559:Ivermectin; C019264:avermectin