title: [Duration of biological activity of pindolol in uremics (author's transl)].
abstract: The duration of biological activity of pindolol following short and long term application was tested using a modified isoproterenol-sensitivity-test. Following a single dose of pindolol the beta-blocking activity in uremics was increased to twice the activity seen in normal controls. Following daily oral application of 10 mg Pindolol over a number of weeks the beta-blockade observed in patients with chronic renal failure was significantly stronger and the duration of action was 6 times longer than in normal controls.
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D010869:Pindolol / Q000494:pharmacology*; D013997:Time Factors; D014511:Uremia / Q000378:metabolism*
chemical_list: D010869:Pindolol; D007545:Isoproterenol
vernacular_title: Wirkdauer von Pindolol bei chronischen Urämikern.