title: The value of radiotherapy in the treatment of vaginal carcinoma.
abstract: Herein we report the retrospective survey of 48 consecutive unselected cases of vaginal carcinoma, mainly treated with radiotherapy in our Institute from 1959 to 1970. In this series irradiation was delivered almost always with a single and continuous application of sources of radium 226. Radiumtherapy treatment varied according to the extension in surface of the neoplasm, the clinical stage and especially the vaginal step involvement, considering the length of the organ. Despite the very good immediate response, failures of treatment locally or in paravaginal and pelvic areas were frequently observed, and success of the treatment after a brief follow-up was poor. The actuarial survival was 41.6% and 33.3% at 3 and 5 years, respectively. Stage I cases showed at the follow-up better therapeutic results (48.6% survival at 5 years) than stage II and III cases (28.3%). The poorest results were observed in neoplasms extended to the whole vagina, and all these patients died within 4 years of the beginning of treatment. This report stresses that radiotherapy of vaginal carcinomas demands individualization and a properly planned therapeutic program that combines external irradiation with renewed techniques of low dose rate and continuous irradiation with radioactive sources.
mesh_terms: D000328:Adult; D001918:Brachytherapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D011883:Radium / Q000008:administration & dosage; D012008:Recurrence; D012075:Remission, Spontaneous; D013997:Time Factors; D014625:Vaginal Neoplasms / Q000473:pathology / Q000532:radiotherapy*
chemical_list: D011883:Radium