Tissue distribution of paraquat and diquat after oral administration in rats.
The differential distribution of paraquat and diquat in liver, kidney, lung, brain and heart has been studied after oral administration of the LD50 or LD50/2 to rats. Paraquat concentrations were highest in all organs at 24 hours; at this time concentrations in kidney and lung were 2 to 3 times higher than at 2 hours. In contrast, with the exception of kidney, tissue diquat concentrations were highest at 2 hours. There was severe lung damage at 24 hours after paraquat; diquat aid not produce severe lung lesions, but caused intestinal distention and diarrhea. These findings suggest that the difference in the toxicity of paraquat and diquat is related to their difference in tissue distribution and excretion.
D000818:Animals; D004178:Diquat / Q000378:metabolism* / Q000494:pharmacology; D007422:Intestines / Q000187:drug effects; D008168:Lung / Q000187:drug effects; D008297:Male; D010269:Paraquat / Q000378:metabolism* / Q000494:pharmacology; D011726:Pyridinium Compounds / Q000378:metabolism*; D051381:Rats; D013997:Time Factors; D014018:Tissue Distribution
D011726:Pyridinium Compounds; D004178:Diquat; D010269:Paraquat