[Effect of the preliminary administration of dextran sulfate on the development of an acute radiation lesion].
Single intraperitoneal administration of dextran sulfate to noninbred mice at a dose of 60 mg/kg 3--24 and 48 hours prior to irradiation in lethal and sublethal doses exerts no radioprotective action. Administration of the drug 24 hours before irradiation increases the intensity of postradiation leukopenia. During irradiation of the animals in a dose of 650 rad dextran sulfate accelerates the recovery of hemopoiesis. With the dose of irradiation being increased up to 750 rad, the drug produces no effect on this parameter.
D000208:Acute Disease; D000818:Animals; D001773:Blood Cells / Q000528:radiation effects; D003911:Dextrans / Q000008:administration & dosage*; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D008297:Male; D051379:Mice; D011833:Radiation Injuries, Experimental / Q000401:mortality / Q000517:prevention & control*; D011837:Radiation-Protective Agents; D013997:Time Factors
D003911:Dextrans; D011837:Radiation-Protective Agents
Vliianie predvaritel'nogo vvedeniia dekstransul'fata na razvitie ostrogo luchevogo porazheniia.