title: Induction of malignant and benign tumors with embryonic tissues.
abstract: The inoculation of viruses into the placenta of fetectomized rats induces the development of malignant tumors from extraembryonic fetal membranes. The same membrane--visceral yolk sac--gives rise to benign teratomas if displaced outside the uterus after fetectomy. Moreover, the transplantation of 3 to 7 day old embroys under the kidney capsule of adult mice gives rise of malignant teratocarcinoma. The methods to induction of these tumors are described.
mesh_terms: D000818:Animals; D004622:Embryo, Mammalian; D005321:Extraembryonic Membranes; D005260:Female; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000209:etiology; D011247:Pregnancy; D051381:Rats; D013724:Teratoma / Q000209:etiology*; D015017:Yolk Sac