A gastroscopic and pharmacological study of the disintegration time and absorption of pivampicillin capsules and tablets.
1 An in vitro investigation showed that pivampicillin tablets disintegrated more rapidly than pivampicillin capsules. This result was demonstrated and confirmed by gastroscopy in a cross-over study in healthy volunteers. 2 There were no differences in serum levels of ampicillin obtained with the two preparations, but compared with non-gastroscoped volunteers, there was delay of 0.5--1.5 h in the appearance of peak serum ampicillin concentrations after gastroscopy. 3 Half of the volunteers receiving pivampicillin capsules developed hyperaemia, interstitial bleeding or erosions of the gastric mucous membrane. No such reactions were seen after pivampicillin tablets. 4 In one volunteer, a pivampicillin capsule was trapped in a not previously noticed hiatus hernia and local changes and pain occurred.
D000328:Adult; D000667:Ampicillin / Q000031:analogs & derivatives* / Q000097:blood; D002214:Capsules; D005773:Gastroscopy; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D010917:Pivampicillin / Q000008:administration & dosage / Q000009:adverse effects / Q000378:metabolism*; D012995:Solubility; D013607:Tablets; D013997:Time Factors
D002214:Capsules; D013607:Tablets; D010917:Pivampicillin; D000667:Ampicillin