Potential biosoluble carriers: biocompatibility and biodegradability of oxidized cellulose.
The biocompatibility and biodegradability of periodate oxidized cellulose is assessed in vivo. Morophological and histopathological studies over a period of six months indicate that oxidized cellulose degrades slowly without producing excessive tissue reaction. Preliminary investigations on the kinetics of degradation of oxidized cellulose in vitro, immobilization of alpha-chymotrypsin on it and the rate of the enzyme release in a solution of pH 7.4 are also briefly reported.
D000818:Animals; D001672:Biocompatible Materials; D001673:Biodegradation, Environmental; D002482:Cellulose / Q000031:analogs & derivatives; D002483:Cellulose, Oxidized; D002918:Chymotrypsin / Q000008:administration & dosage; D003238:Connective Tissue / Q000033:anatomy & histology; D003692:Delayed-Action Preparations; D004800:Enzymes, Immobilized / Q000008:administration & dosage; D066298:In Vitro Techniques; D051381:Rats; D012826:Silicone Elastomers; D012867:Skin / Q000033:anatomy & histology; D012995:Solubility; D013499:Surface Properties
D001672:Biocompatible Materials; D002483:Cellulose, Oxidized; D003692:Delayed-Action Preparations; D004800:Enzymes, Immobilized; D012826:Silicone Elastomers; D002482:Cellulose; D002918:Chymotrypsin