Effect of hypoxia on 67Ga incorporation into human granulocytes.
Human granulocytes accumulate 67Ga when incubated under anoxic conditions and exclude the isotope when oxygenated. When incorporated, 67Ga is associated with the lysosomal fraction of the granulocytes. The ability of granulocytes to exclude the isotope except under hypoxic conditions may explain 67Ga localization in abscesses and some tumor masses.
D000328:Adult; D005710:Gallium Radioisotopes; D006098:Granulocytes / Q000378:metabolism*; D006801:Humans; D000860:Hypoxia; D066298:In Vitro Techniques; D007249:Inflammation / Q000000981:diagnostic imaging; D008214:Lymphocytes / Q000378:metabolism; D009369:Neoplasms / Q000000981:diagnostic imaging; D010100:Oxygen; D011877:Radionuclide Imaging
D005710:Gallium Radioisotopes; D010100:Oxygen