Management of localized thoracic neuroblastoma.
Thirteen children with localized (Evans stage I or II) thoracic primary neuroblastoma were divided into two groups according to the type of therapy administered, in order to compare the therapeutic efficacy and morbidity of excisional surgery followed by either irradiation alone or irradiation plus chemotherapy (group A) with similar surgery alone (group B). Group A consisted of 6 children (mean age 1 year, 2 months). Complete surgical excision was accomplished in 2 patients, while 4 had microscopic residual. All 6 patients are free of disease at 26--76 months (mean 47 months), including 2 who had recurrent tumor and received additional therapy. Two have developed congestive heart failure and one severe scoliosis secondary to irradiation. Of the 7 children in group B (mean age 2 years, 2 months), 3 had microscopic residual tumor and 2 had adjacent lymph node involvement. After 12--47 months (mean 23 months), no recurrence or surgery-related morbidity has been observed. From these limited data it appears that surgery alone may provide adequate therapy for localized thoracic neuroblastoma and obviate the morbidity associated with multimodal therapy.
D002675:Child, Preschool; D003520:Cyclophosphamide / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005729:Ganglioneuroma / Q000628:therapy*; D006333:Heart Failure / Q000209:etiology; D006801:Humans; D007223:Infant; D009447:Neuroblastoma / Q000628:therapy*; D011832:Radiation Injuries; D011867:Radioisotope Teletherapy; D012008:Recurrence; D012075:Remission, Spontaneous; D012600:Scoliosis / Q000209:etiology; D013899:Thoracic Neoplasms / Q000628:therapy*; D014750:Vincristine / Q000008:administration & dosage
D014750:Vincristine; D003520:Cyclophosphamide