Subacute sclerosing panencephalitis after drug-induced immunosuppression.
A girl developed subacute sclerosing panencephalitis (SSPE). Eight years earlier she had had measles infection contracted shortly after cytotoxic treatment and radiotherapy for a spinal neuroblastoma. The case illustrates that typical SSPE, like immunosuppressive measles encephalopathy, can arise after drug-induced immunosuppression, and supports the view that these diseases probably represent opposite ends of a spectrum induced by measles virus infection in an individual with some form of immunological deficiency.
D002648:Child; D003520:Cyclophosphamide / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy; D008457:Measles / Q000150:complications*; D013344:Subacute Sclerosing Panencephalitis / Q000209:etiology*
D003520:Cyclophosphamide