title: Squamous metaplasia of the endometrium. Endometrial response to intrauterine presence of fibroblast-carrying Ivalon sponge.
abstract: Squamous metaplasia of the endometrium was detected in 3 women out of ten in which fibroblast-carrying Ivalon sponge (produced by implanting the sponge subcutaneously for 6 to 8 weeks) was inserted into the uterus following dilatation and curettage. The experiments were carried out in view of previous successful similar procedures in rabbits to produce fibroblastic bridges inside the uterus, and to avoid the patients from undergoing major surgery (hysterectomy) if possible, and at the same time to use the experiment as a model of contraception procedure. Since no improvement was experienced by the patients, which continued to have excessive blood loss, hysterectomies were performed at a later date, and the specimens were thoroughly examined. The possible effect of the Ivalon sponge (acting as IUCD) on the endometrium is discussed.
mesh_terms: D000328:Adult; D004717:Endometrium / Q000473:pathology*; D005260:Female; D005347:Fibroblasts / Q000637:transplantation; D006801:Humans; D008679:Metaplasia / Q000209:etiology; D008875:Middle Aged; D014184:Transplantation, Homologous; D014592:Uterine Hemorrhage / Q000628:therapy*; D014599:Uterus / Q000601:surgery