Reversibility of the toxicity of methotrexate by dihydrofolate in mice.
1. Dihydrofolate in mice can reverse the toxicity of a lethal dose of methotrexate. 2. The 'rescue' of mice after a lethal dose of methotrexate suggests that dihydrofolate could have a clinical use as an antidote in treating methotrexate-induced toxicity.
D000818:Animals; D005492:Folic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D008727:Methotrexate / Q000037:antagonists & inhibitors* / Q000633:toxicity; D051379:Mice; D008806:Mice, Inbred AKR; D013997:Time Factors
C010920:dihydrofolate; D005492:Folic Acid; D008727:Methotrexate