Effect of oestradiol-17 beta and progesterone on oviductal transport and early development of mouse embryos.
Transport of embryos through the oviduct, cleavage rate and transformation of morulae to blastocysts, were delayed in females ovariectomized on Day 2 of pregnancy. Oestradiol-17 beta in doses of 60 to 6000 pg/day for 3 days did not normalize the transport of embryos, but the transformation of morulae to blastocysts reached values near or equal to those of the controls, in spite of a lowered rate of cleavage. Progesterone at a dose of 100 micrograms/day, resulted in normal transport, rate of cleavage and rate of differentiation. Treatment with both hormones had synergistic effects on transport and the rate of cleavage and differentiation. These results give further support to the concept that ovarian hormones are the controlling factors for these processes in early pregnancy.
D000818:Animals; D001757:Blastomeres / Q000187:drug effects; D002369:Castration; D004357:Drug Synergism; D004622:Embryo, Mammalian / Q000187:drug effects*; D004958:Estradiol / Q000494:pharmacology*; D005187:Fallopian Tubes / Q000187:drug effects / Q000502:physiology*; D005260:Female; D051379:Mice; D009028:Morula / Q000187:drug effects; D010066:Ovum Transport / Q000187:drug effects*; D011247:Pregnancy; D011374:Progesterone / Q000494:pharmacology*
D011374:Progesterone; D004958:Estradiol