The effects of physostigmine on amitriptyline induced cardiotoxicity in dogs.
When 0.5 mgs of physostigmine salicylate was injected intravenously into adult beagle dogs which had been severely poisoned with amitriptyline, a transient improvement in cardiac output, systolic blood pressure, intraventricular conduction and in the maximum rate of rise of arterial blood pressure (arterial dP/dT max.) was observed. These effects were maximal at 15-20 minutes after injection and had largely disappeared 30 to 35 minutes after the injection.
D000639:Amitriptyline / Q000506:poisoning*; D000818:Animals; D004285:Dogs; D006331:Heart Diseases / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology; D010830:Physostigmine / Q000627:therapeutic use*
D000639:Amitriptyline; D010830:Physostigmine