Activity of Schistosoma mansoni over a ten-hour period in vitro, and its modification by oxamniquine.
The activity of pairs of adult Schistosoma mansoni maintained in a continuous flow culture system was monitored for ten hours using the ultrasound method of Brown, Norman, Bell and Chavasse (1978). The results of 75 experiments were collated by computer to demonstrate the average effect of oxamniquine on worm activity in vitro at concentrations from 0.2 microgram/ml to saturation. The averaging technique indicates that oxamniquine concentrations down to 0.2 microgram/ml modify worm activity in vitro.
D000204:Activity Cycles / Q000187:drug effects; D000818:Animals; D004305:Dose-Response Relationship, Drug; D051379:Mice; D009068:Movement / Q000187:drug effects; D009600:Nitroquinolines / Q000494:pharmacology*; D010073:Oxamniquine / Q000494:pharmacology*; D012550:Schistosoma mansoni / Q000187:drug effects*
D009600:Nitroquinolines; D010073:Oxamniquine