Prenatal diagnosis of beta-thalassaemia by fetal red cell concentration with anti-AB serum.
Prenatal diagnosis by globin chain synthesis analysis on fetal blood samples obtained by placental aspiration was performed in two pregnancies at risk for beta-thalassaemia. Since both fathers had blood group AB, and both mothers had group O, fetal red cell concentration from maternal-fetal mixtures was obtained with the aid of anti-AB serum. With this approach it was possible to carry out globin chain synthesis analysis with very small amounts of fetal blood. Heterozygous and normal genotypes were ascertained and confirmed after birth.
D000017:ABO Blood-Group System; D000372:Agglutination Tests; D005260:Female; D005312:Fetal Blood / Q000032:analysis*; D005914:Globins / Q000032:analysis; D006801:Humans; D007106:Immune Sera; D011247:Pregnancy; D011296:Prenatal Diagnosis; D013789:Thalassemia / Q000175:diagnosis* / Q000235:genetics
D000017:ABO Blood-Group System; D007106:Immune Sera; D005914:Globins