Inhibition of galactosamine induced edemas in the rat by drugs preventing macromolecular leakage from the hamster cheek pouch microvasculature.
We have shown that terbutaline and dimethpyrindene, 2 drugs which prevent macromolecular leakage in the in vivo--bio-assay of Hamster Cheek Pouch, either by direct action onendothelial cells or by blocking histamine receptors at the microvascular leakage sites, can also prevent macromolecular leakage in vivo in 2 different models of generalized edema.
D000818:Animals; D002199:Capillary Permeability; D002610:Cheek / Q000098:blood supply; D006224:Cricetinae; D003911:Dextrans; D004115:Dimethindene / Q000494:pharmacology; D004195:Disease Models, Animal; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D005688:Galactosamine; D046911:Macromolecular Substances; D008833:Microcirculation; D051381:Rats; D013726:Terbutaline / Q000494:pharmacology
D003911:Dextrans; D046911:Macromolecular Substances; D004115:Dimethindene; D005688:Galactosamine; D013726:Terbutaline