[Blood serum enzymes in assessing the nature of the liver lesion and the effectiveness of chemotherapeutic actions in acrylonitrile poisoning].
After intraperitoneal administration of acrylonitrile into rats, fructose monophosphate aldolase was found in blood serum, activity of butyryl cholinesterase was inhibited but activity of alkaline phosphatase was unaltered in rat blood serum; these data demonstrate the necro-bystrophic type impairment. Decrease in the hepatotoxic effect of acrylonitrile after preadministration of antioxidants appears to be a result of stimulation of lipid peroxidation, preventing the toxic effect of this industrially important substance.
D000181:Acrylonitrile / Q000506:poisoning* / Q000633:toxicity; D000469:Alkaline Phosphatase / Q000097:blood*; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage; D002091:Butyrylcholinesterase / Q000097:blood*; D002802:Cholinesterases / Q000097:blood*; D004796:Clinical Enzyme Tests; D003937:Diagnosis, Differential; D004347:Drug Interactions; D005260:Female; D005634:Fructose-Bisphosphate Aldolase / Q000097:blood*; D008099:Liver / Q000187:drug effects*; D008297:Male; D009570:Nitriles / Q000506:poisoning*; D010634:Phenobarbital / Q000008:administration & dosage; D051381:Rats; D013997:Time Factors
D000975:Antioxidants; D009570:Nitriles; D002091:Butyrylcholinesterase; D002802:Cholinesterases; D000469:Alkaline Phosphatase; D005634:Fructose-Bisphosphate Aldolase; D000181:Acrylonitrile; D010634:Phenobarbital
Fermenty syvorotki krovi v otsenke kharaktera porazheniia pecheni i éffektivnosti khimioterapevticheskikh vozdeĭstviĭ pri otravlenii akrilonitrilom.