Failure to detect circulating immune complexes in allergic patients on injection therapy.
Injection therapy for allergic diseases may create an environment conducive to circulating immune complex formation. Therefore, we examined the sera of eleven patients receiving injection therapy for the presence of circulating immune complexes. A sensitive Raji cell radioimmune assay was used to examine the sera prior to and 4, 8 and 24 hours after allergenic injection. Levels measured in these sera were compared to values obtained from forty-two healthy controls. Ten of eleven allergic patients receiving injection therapy had values within the normal range prior to maintenance injection. These ten patients also had normal values for circulating immune complexes at each interval after maintenance injection. The data suggest that circulating immune complexes are not a routine consequence of injection therapy for allergic disease.
D000328:Adult; D000368:Aged; D000485:Allergens / Q000008:administration & dosage*; D000936:Antigen-Antibody Complex; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology* / Q000628:therapy; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D013997:Time Factors
D000485:Allergens; D000936:Antigen-Antibody Complex