Microbial transformations and 13C-NMR analysis of colchicine.
Several microorganisms were screened for their ability to biotransform colchicine, and two were selected for preparative scale fermentations. Streptomyces spectabilis and Streptomyces griseus both produced O2-demethylcolchicine and O3-demethylcolchicine but in different amounts. The 13C-NMR assignments of colchicine, O10-demethylcolchicine, and trimethylcolchicinic acid are reported and were used to help identify the structures of the metabolites.
D001419:Bacteria / Q000378:metabolism; D001711:Biotransformation; D003078:Colchicine / Q000032:analysis / Q000378:metabolism*; D005285:Fermentation; D005658:Fungi / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D013302:Streptomyces / Q000378:metabolism
D003078:Colchicine