Porphobilinogen synthetase activity response to increased levels of reduced glutathione produced by methylene blue, in blood, liver and kidney.
We have studied the effect of methylene blue on GSH and GSSG levels in rat blood, liver and kidney. Methylene blue treatment increases GSH levels and PBG-synthetase activity in erythrocytes while liver and kidney GSH and GSSG levels remain constant. These results indicate that methylene blue effect on PBG-synthetase activity in rat erythrocytes is mediated by an increase in blood GSH levels.
D000818:Animals; D004912:Erythrocytes / Q000378:metabolism; D005978:Glutathione / Q000097:blood / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D008751:Methylene Blue / Q000494:pharmacology*; D010084:Oxidation-Reduction; D000623:Porphobilinogen Synthase / Q000097:blood / Q000378:metabolism*; D051381:Rats
D000623:Porphobilinogen Synthase; D005978:Glutathione; D008751:Methylene Blue