Increased erythrocyte lipid peroxidation in hereditary xerocytosis.
Xerocytosis is a chronic hemolytic anemia with abnormal membrane function manifested by an increase in passive potassium permeability. Xerocytes demonstrate a greater susceptibility to hydrogen peroxide manifested by the production of malondialdehyde (MDA). Xerocyte membrane phospholipid and fatty acid analysis is normal except for a slight increase in phosphatidyl choline, a commensurate decrease in sphingomyelin, as well as a decrease in linoleic acid. Metabolism and glutathione stability are normal as well as plasma vitamin E levels in patients with xerocytosis. The increased susceptibility to oxidant stress is exaggerated in the "older aged" xerocyte population and correlated well with decreased intracellular potassium concentration.
D000745:Anemia, Hemolytic, Congenital / Q000097:blood*; D002463:Cell Membrane Permeability; D002784:Cholesterol / Q000097:blood; D004912:Erythrocytes / Q000378:metabolism*; D005227:Fatty Acids / Q000097:blood; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood*; D008315:Malondialdehyde / Q000097:blood; D010743:Phospholipids / Q000097:blood
D005227:Fatty Acids; D008054:Lipid Peroxides; D010743:Phospholipids; D008315:Malondialdehyde; D002784:Cholesterol