title: Activity and effective serum level of repository sulphones (DADDS) in lepromatous leprosy.
abstract: 35 cases of lepromatous leprosy were studied to evaluate the effective blood level and long depot action of acedapsone (DADDS). It was revealed that serum level of this drug is maintained well above the minimum inhibitory concentration upto 60 days following single intramuscular injection. No significant untoward effects of the drug were encountered except one case of Erythema Nodosum Leprosum and six patients with mild reactional symptoms in the form of fever and arthralgia.
mesh_terms: D000072:Acedapsone / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use*; D000328:Adult; D003622:Dapsone / Q000031:analogs & derivatives*; D003692:Delayed-Action Preparations; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D007918:Leprosy / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged
chemical_list: D003692:Delayed-Action Preparations; D000072:Acedapsone; D003622:Dapsone