[Effects of choledochal perfusion with biliary acid solutions on activity of the sphincter of Oddi (author's transl)].
The changes of sphincter of Oddi's resistance, induced by choledochal perfusion of conjugated (taurocolic) and non-conjugated (colic) biliary acid solutions, in anesthetized dogs, were studied. The perfusions were made at a constant flow and intracholedochal pressures were registered. The mean number of contractions per minute, the mean maximal pressures and the mean minimal pressures in each study periods were analysed. The choledochal perfusion with the biliary acids solutions induced a slight but significative increase in sphincteric resistance. After 15 minutes, the perfusion with colic acid solution induced maximal pressures significantly more elevated than the ones observed with taurocolic acid solution. The non-conjugated solution induced a pressure tracing significantly distinct from the tracing observed with the conjugated acid solution. No changes in resistance were observed with a 2% NaCl solution. This implies that the observed changes in resistance were not related to osmotic stimulation of the sphincter of Oddi.
D014670:Ampulla of Vater / Q000502:physiology*; D000818:Animals; D001647:Bile Acids and Salts / Q000494:pharmacology / Q000502:physiology*; D002793:Cholic Acids / Q000494:pharmacology; D003135:Common Bile Duct / Q000187:drug effects / Q000502:physiology*; D004285:Dogs; D009994:Osmolar Concentration; D010477:Perfusion; D011312:Pressure; D009803:Sphincter of Oddi / Q000502:physiology*; D013656:Taurocholic Acid / Q000494:pharmacology
D001647:Bile Acids and Salts; D002793:Cholic Acids; D013656:Taurocholic Acid
Efeitos da perfusão do colédoco com soluções de acidos biliares sobre a atividade do esfincter de Oddi.