title: The effect of cerebrospinal fluid pressure on perilymphatic flow in the opened cochlea.
abstract: Scala tympani of guinea pigs was perfused with elevated potassium solutions whose concentraus recovery, the concentration curve showed a 'break' approximately 3 min after perfusion ceased. When the CSF pressure was released by opening the cisterna magna, cochlear flow was markedly reduced, and the recovery curve became smoothly exponential, following a much slower return to control levels. This finding lends support to the idea proposed by Moscovitch, Gannon & Laszlo (1973) that longitudinal flow of CSF contributes to perilymph efflux in the patent cochlea.
mesh_terms: D000818:Animals; D002555:Cerebrospinal Fluid / Q000502:physiology*; D002946:Cisterna Magna / Q000502:physiology; D003051:Cochlea / Q000502:physiology*; D006168:Guinea Pigs; D010477:Perfusion; D010498:Perilymph / Q000502:physiology; D011188:Potassium / Q000494:pharmacology; D011312:Pressure; D012533:Scala Tympani / Q000187:drug effects / Q000502:physiology*
chemical_list: D011188:Potassium