title: Studies on ocular blood flow and retinal capillary permeability to sodium in pigs.
abstract: A surgical technique was developed in pigs that permits access to the retinal venous plexus surrounding the optic nerve. The effect of surgery on ocular blood flow and capillary permeability was evaluated. Blood flow, determined by the labelled microsphere technique, did not differ significantly between operated and control eyes. Increased intraocular pressure in the operated eye reduced blood flow through the choroid and the anterior uvea in proportion to the reduction in perfusion pressure, while in the retina a smaller reduction in blood flow occurred indicating that autoregulatory mechanisms are involved in the control of retinal blood flow. The capillary permeability to sodium was studied by the single injection technique, using albumin as a reference substance. The fractional initial extractions from the choroidal and the retinal vessels were 0.77 and -0.001 respectively. The absence of a sodium extraction from the retinal vessel indicates that this part of the blood-retinal barrier was intact and that the blood drained by the retinal plexus is not mixed with blood from other sources.
mesh_terms: D000818:Animals; D002199:Capillary Permeability; D002404:Catheterization; D002829:Choroid / Q000098:blood supply; D005123:Eye / Q000098:blood supply*; D005260:Female; D007429:Intraocular Pressure; D008297:Male; D008863:Microspheres; D012039:Regional Blood Flow; D012171:Retinal Vessels / Q000502:physiology*; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage; D012964:Sodium / Q000097:blood*; D013552:Swine
chemical_list: D012462:Saline Solution, Hypertonic; D012964:Sodium