title: Membrane response to 1-methyladenine requires the presence of the nucleus.
abstract: Meiosis is re-initiated in starfish oocytes by the action of the hormone 1-methyladenine (1-MA). It is thought that the primary trigger is localised at the plasma membrane, and early changes reported are the activation of a Na+ pump and variation in membrane potential and conductance. We report here that external application of 1-MA results in an irreversible switching of the starfish oocyte membrane from one stable electrical state to another. This induced change requires the presence of the germinal vesicle.
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D002467:Cell Nucleus / Q000648:ultrastructure; D005260:Female; D006728:Hormones / Q000494:pharmacology*; D008540:Meiosis / Q000187:drug effects; D008564:Membrane Potentials / Q000187:drug effects; D009865:Oocytes / Q000187:drug effects / Q000502:physiology* / Q000648:ultrastructure; D010063:Ovum / Q000502:physiology*; D013215:Starfish
chemical_list: D006728:Hormones; C008407:1-methyladenine; D000225:Adenine