Erythrocyte rheology in acute cerebral thrombosis. Effects of ABO blood groups.
Within a few hours after a cerebral thrombosis in 220 patients, the flow-properties of the red blood cells (RBC) were analyzed by a filtration test that expresses quantitatively the deformability and aggregability of the RBC by the filtration indexes pT. Abnormal deformability of the RBC washed clean of plasma was found in 27.5% of the patients. Aggregability disorders, caused by the plasma trapped between the unwashed RBC, were found in 78.6% of the patients: computation of correlation coefficients between pT indexes and fibrinogen, which was found abnormally high in 88.2% of cases, demonstrated significantly that in the patients with A and B blood groups these aggregability disorders were due to fibrinogen and that they were caused by other components of plasma in patients with O and AB blood groups. All these disorders can account for blood hyperviscosity.
D000017:ABO Blood-Group System; D000208:Acute Disease; D004903:Erythrocyte Aggregation; D004912:Erythrocytes; D005340:Fibrinogen / Q000032:analysis; D005374:Filtration; D006801:Humans; D002542:Intracranial Embolism and Thrombosis / Q000097:blood*; D012212:Rheology
D000017:ABO Blood-Group System; D005340:Fibrinogen