Assessment of the anaesthetic and metabolic activities of dioxychlorane, a new halogenated volatile anaesthetic agent.
The ability of dioxychlorane to depress cortical activity in rats with implanted electrodes was compared to that reported previously for methoxyflurane, halothane and enflurane. Dioxychlorane was eight times more potent than enflurane, five times more potent than halothane and twice as potent as methoxyflurane. Serum fluoride concentrations after the administration of dioxychlorane and enflurane were not different from controls. In contrast, serum fluoride concentrations after methoxyflurane reached a value of 105 mumol litre-1 and remained increased for at least the next 48 h. Urine fluoride concentrations in the dioxychlorane and enflurane groups were a half and a quarter, respectively, of those recorded in the methoxyflurane group. Polyuria and polydipsia were observed only in the methoxyflurane group. Dilatation of the proximal convoluted tubules was noted in the rats anesthetized with methoxyflurane. These changes were most marked at the 6- and 24-h periods following anaesthesia. Haemorrhage and ulcerative cystitis were noted in the bladders of the rats subjected to methoxyflurane. Cellular swelling in the proximal tubule was observed in the rats sacrificed 24 h after the administration of dioxychlorane. Enflurane produced no pathological changes.
D000777:Anesthetics / Q000378:metabolism; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects; D004148:Dioxolanes / Q000378:metabolism / Q000494:pharmacology*; D004149:Dioxoles / Q000494:pharmacology*; D004326:Drinking; D004435:Eating; D004569:Electroencephalography; D004737:Enflurane / Q000378:metabolism / Q000494:pharmacology; D005459:Fluorides / Q000652:urine; D006221:Halothane / Q000378:metabolism / Q000494:pharmacology; D008297:Male; D008733:Methoxyflurane / Q000378:metabolism / Q000494:pharmacology; D051381:Rats; D014554:Urination / Q000187:drug effects
D000777:Anesthetics; D004148:Dioxolanes; D004149:Dioxoles; D008733:Methoxyflurane; C022935:dioxychlorane; D004737:Enflurane; D005459:Fluorides; D006221:Halothane