Enhanced stability of the Na+-dependent amino acid-transport system after lymphocyte activation.
The Na+-dependent transport system for the amino acid proline in unstimulated lymphocytes decays with a half-life of about 4 h when protein synthesis is inhibited by cycloheximide, but the system in mitogen-activated lymphocytes is more stable. However, the early increase in activity of this transport system after mitogen addition is not due to a direct effect on its stability, but is a secondary effect requiring protein synthesis.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D003513:Cycloheximide / Q000494:pharmacology; D006207:Half-Life; D066298:In Vitro Techniques; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism*; D010835:Phytohemagglutinins / Q000494:pharmacology; D011392:Proline / Q000097:blood*; D014176:Protein Biosynthesis; D012964:Sodium / Q000097:blood*; D013552:Swine
D010835:Phytohemagglutinins; D003513:Cycloheximide; D011392:Proline; D012964:Sodium