Effect of glomerulopressin on ovarian blood flow in dogs.
The present study showed that glomerulopressin decreased ovarian blood flow in normal dogs and that this effect could be inhibited by treatment with indomethacin. In addition diabetic dogs had a high plasma level of glomerulopressin and a low ovarian blood flow that was shown to increase after treatment with indomethacin. This suggests that the low ovarian blood flow in diabetis might be due to a prostaglandin synthesizing effect of glomerulopressin.
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology; D004285:Dogs; D005215:Fasting; D005260:Female; D005965:Glucuronates / Q000494:pharmacology*; D007213:Indomethacin / Q000494:pharmacology; D010053:Ovary / Q000098:blood supply* / Q000187:drug effects; D012039:Regional Blood Flow / Q000187:drug effects
D005965:Glucuronates; C014007:glomerulopressin; D007213:Indomethacin