Enhancing effect of clamping of the portal vein on the effectiveness of antitumor agents against lymph node metastasis.
An experimental study was made on the suppressive effect on lymph node metastasis of an antitumor agent administered during the clamping of the portal vein. When mitomyaneously clamped, a higher concentration of the drug was detected in the mesenteric lymph nodes compared to the conventional intravenous administration. The growth of mesenteric lymph node metastasis was markedly suppressed by the combined use of mitomycin-C and portal vein clamping. These results suggest that the procedure applied in the present study directs a high concentration of antitumor preparations to the lymph nodes in the portal vein region, and thus is a good method for the suppression of lymph node metastasis.
D000818:Animals; D003250:Constriction; D005260:Female; D007267:Injections; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy* / Q000378:metabolism; D008198:Lymph Nodes / Q000032:analysis; D008207:Lymphatic Metastasis / Q000517:prevention & control*; D008937:Mitomycins / Q000008:administration & dosage* / Q000378:metabolism / Q000627:therapeutic use; D011169:Portal Vein / Q000502:physiology*; D051381:Rats
D008937:Mitomycins