No stimulatory effect of added histones on DNA synthesis in isolated HeLa cell nuclei.
Contrary to some recent reports DNA synthesis in isolated HeLa cell nuclei was not stimulated by the addition of low amounts of histones neither in the presence nor in the absence of cytosol. The individual histone fractions H1, H2A, H2B and H3 also failed to stimulated DNA synthesis.
D002467:Cell Nucleus / Q000378:metabolism; D004247:DNA / Q000096:biosynthesis*; D006367:HeLa Cells / Q000378:metabolism*; D006657:Histones / Q000494:pharmacology*; D006801:Humans; D013268:Stimulation, Chemical
D006657:Histones; D004247:DNA