Left ventricular failure with labetalol.
A patient treated for hypertension with labetalol developed left ventricular failure. When the drug was withdrawn and the BP controlled with 2 other agents, the signs of heart failure regressed. The ill effects in this case could have been because the beta-blocking effects of labetalol are 4 to 6 times greater than the alpha-blocking effects. Caution should be exercised when prescribing this drug for patients with heart failure or with previous symptoms.
D000328:Adult; D004983:Ethanolamines / Q000009:adverse effects*; D006331:Heart Diseases / Q000150:complications; D006333:Heart Failure / Q000139:chemically induced*; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy; D007741:Labetalol / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male
D004983:Ethanolamines; D007741:Labetalol