[Cardiovascular and respiratory reflex responses due to stimulation of muscle nerve receptors and experimental physical exercise].
The cardiovascular and respiratory reflex effects brought on by the infection into the femoral artery of bradyquinine and of hypertonic sodium chloride solutions and by rhythmic muscular work and muscular work of tetanic type induced by low and high frequency electrostimulation in the muscles have been investigated in the rear extremity anaesthetized rabbits. Intra-arterial injection of bradyquinine and rhythmic muscular contractions trigger off cardiovascular reflux effects of inhibitory type represented by a reduction in arterial pressure, heart frequency and vascular resistances of the rear extremity controlateral to the one stimulated. Intra-arterial injection of hypertonic NaCl and tetanic contractions cause opposite effects, namely of decidedly excitatory type. Such responses are not substantially altered by complete removal of the skin layer of the stimulated extremity. The neuromuscular block obtained with curare-like substances does not affect chemical stimulation responses, whereas it eliminates similar effects caused by experimental muscular work. The experiments carried out show that injection into the muscular arteries of chemical agents of various type produces varying cardiovascular reflex effects as a result of activation of chemosensitive nervous receptors located in the muscular tissue, and also that during physical exercise similar reflex modifications are produced, very probably caused by stimulation of receptors present in the contracting muscles.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001920:Bradykinin / Q000494:pharmacology*; D002628:Chemoreceptor Cells / Q000187:drug effects*; D005260:Female; D006321:Heart / Q000502:physiology*; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D005082:Physical Exertion; D011817:Rabbits; D012018:Reflex / Q000187:drug effects; D012143:Respiratory Physiological Phenomena; D012965:Sodium Chloride / Q000494:pharmacology*; D014655:Vascular Resistance / Q000187:drug effects
D012965:Sodium Chloride; D001920:Bradykinin
Risposte riflesse cardiovascolari e respiratorie da stimolazione di recettori nervosi muscolari e da esercizio fisico sperimentale.