title: Comparison of carcinogenicity studies with aldrin and dieldrin.
abstract: Laboratory testing of animals is the principal method used to identify chemical carcinogens. However conflicting results are often obtained. This is emphasized in a cross-comparison of 6 aldrin-dieldrin studies; 3 were positive for tumor induction and 3 were negative. Four components of the assays are examined: husbandry, compound administration, observation, and interpretation of results.
mesh_terms: D000452:Aldrin / Q000008:administration & dosage / Q000633:toxicity*; D000822:Animal Husbandry; D000818:Animals; D002273:Carcinogens; D004026:Dieldrin / Q000008:administration & dosage / Q000633:toxicity*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D051379:Mice; D051381:Rats; D012107:Research Design
chemical_list: D002273:Carcinogens; D004026:Dieldrin; D000452:Aldrin