title: The effects of nitrous oxide on the developing hamster embryos.
abstract: Pregnant hamsters were exposed to different concentrations of nitrous oxide during the period of organogenesis. Teratogenic effects were observed in a small but significant number of fetuses. Types of malformations included cleft palate, limb defects, gut herniation, and fetal edema. A dose-effect relationship was not observed. It is not clear from our observations whether the observed effect on the fetuses was due to the excess of nitrous oxide, hypoxia, or a combination of both. Comparison with published literature indicates that further studies on the effects of nitrous oxide in placental animals are needed.
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000209:etiology; D000818:Animals; D006224:Cricetinae; D004622:Embryo, Mammalian / Q000187:drug effects; D005260:Female; D005327:Fetal Resorption / Q000139:chemically induced; D005333:Fetus / Q000187:drug effects*; D008297:Male; D009609:Nitrous Oxide / Q000494:pharmacology*; D011247:Pregnancy; D013045:Species Specificity; D013997:Time Factors
chemical_list: D009609:Nitrous Oxide