title: Effects of contusion and flail chest on pulmonary perfusion and oxygen exchange.
abstract: Localized pulmonary contusions were produced in the right lower lobes (RLL) of 12 anesthetized ventilated dogs, 6 of which had a flail segment in the chest wall over the RLL. Pulmonary oxygen exchange during ventilation with air and oxygen, and the lobar distribution of pulmonary perfusion by radioactive microsphere techniques were measured before and 3 h after contusion, and again after thoracotomy. These were compared to 12 noncontused dogs, 6 of which had a flail segment. Contusion produced an average decrease of 20 Torr in Pao2 during air breathing and an average increase in Qs/Qt of less than 5%, surprisingly small given the doubled weight and average 44% shunt calculated in the contused lobe after thoracotomy. No significant effect of flail or thoracotomy was found, indicating that the presence of an intact chest wall and lung-chest wall interdependence was not a major factor preventing a larger increase in intact whole-animal shunt of contused dogs. Rather, the small effect of this severe lobar injury on whole-animal shunt was due to a 30% decrease in RLL relative perfusion. This reduction was demonstrated to be localized to a smaller hemorrhagic subsection of the contused lobe.
mesh_terms: D000818:Animals; D003288:Contusions / Q000150:complications / Q000503:physiopathology*; D004285:Dogs; D005260:Female; D005409:Flail Chest / Q000150:complications / Q000503:physiopathology*; D055370:Lung Injury; D008297:Male; D010100:Oxygen / Q000097:blood; D011652:Pulmonary Circulation; D012119:Respiration; D013898:Thoracic Injuries / Q000503:physiopathology*
chemical_list: D010100:Oxygen