Racial differences of parameters associated with blood pressure levels in children--the Bogalusa heart study.
Racial differences in prevalence of essential hypertension are well known. In order to explore these differences at an early age in terms of etiology, we investigated schoolchildren in an entire, biracial community. A sample of 278 children, stratified by diastolic (fourth-phase) blood pressure and specific for age, race, and sex, was reexamined 1--2 yr after initial observation for the following: (1) a physical examination and urinalysis to exclude secondary hypertension; (2) 24-hr urine sodium, potassium, plasma renin activity, and serum dopamine beta-hydroxylase; (3) 1-hr oral glucose tolerance test; and (4) heart rate and blood pressure at rest and under standarized physical stress. We found that 24-hr urine sodium was positively associated with blood pressure level as measured on the same day for the high blood pressure strata of black children. Urine potassium excretion was lower in blacks than in whites, although their intakes seemed equal. In the high blood pressure strata especially, black boys had lower renin activity than whites, and the resting-supine and stressed systolic blood pressures were higher in black boys than in any other group. In these black boys, resting and stressed systolic pressures were negatively related to plasma renin activity. On the other hand, dopamine beta-hydroxylase levels in white children were higher than in blacks for all blood pressure strata, and in the high blood pressure strata white children had higher 1-hr glucose levels and faster resting heart rates than black children. Different mechanisms may play a role in and contribute to the early stage of essential hypertension.
D000293:Adolescent; D000367:Age Factors; D044383:Black People; D001794:Blood Pressure; D002648:Child; D002675:Child, Preschool; D004299:Dopamine beta-Hydroxylase / Q000097:blood; D004573:Electrolytes / Q000097:blood / Q000652:urine; D005260:Female; D005951:Glucose Tolerance Test; D006339:Heart Rate; D006801:Humans; D007328:Insulin / Q000097:blood; D008145:Louisiana; D008297:Male; D005082:Physical Exertion; D012737:Sex Factors; D014527:Uric Acid / Q000097:blood; D044465:White People; D001741:Black or African American
D004573:Electrolytes; D007328:Insulin; D014527:Uric Acid; D004299:Dopamine beta-Hydroxylase