[Allergenic and anaphylactoid properties of carcinostatic compounds of platinum].
Different effects of platinum salts on the organism were studied comparatively. The toxic effect was estimated by LD50; the carcinogenic one--by the action on Ehrlich ascites tumor; the anaphylactoid effect was evaluated by the degree of the arterial pressure fall, the development of bronchospasm and an increased blood histamine level in cats under intravenous injection of platinum salts. The sensitization action of platinum salts was assessed on guinea pigs. All these effects are found to be dependent on the salts chemical composition, and they are manifested in an independent route.
D000485:Allergens; D000707:Anaphylaxis / Q000139:chemically induced*; D000818:Animals; D000970:Antineoplastic Agents; D001794:Blood Pressure / Q000187:drug effects; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D002415:Cats; D002945:Cisplatin / Q000276:immunology* / Q000633:toxicity; D004306:Dose-Response Relationship, Immunologic; D006168:Guinea Pigs; D007114:Immunization; D007928:Lethal Dose 50; D051379:Mice; D013329:Structure-Activity Relationship
D000485:Allergens; D000970:Antineoplastic Agents; D002945:Cisplatin
Allergennye i anafilaktoidnye svoĭstva kantserostaticheskikh soedineniĭ platiny.