Biological effects of negative pions in monolayers and spheroids of Chinese hamster cells.
The therapeutic value of pion irradiation was critically challenged by examining, in a cell culture system, various parameters of biological significance such as relative biological efficiency (RBE), oxygen enhancement ratio (OER), DNA-break formation, changes in cell cycle kinetics and regrowth. In all parameters, pions were superior to conventional low-LET radiation.
D000818:Animals; D002453:Cell Cycle / Q000528:radiation effects; D002478:Cells, Cultured / Q000528:radiation effects*; D006224:Cricetinae; D003412:Cricetulus; D004247:DNA / Q000528:radiation effects; D004601:Elementary Particles; D066298:In Vitro Techniques; D010100:Oxygen; D012062:Relative Biological Effectiveness
D004247:DNA; D010100:Oxygen