Sensitive assay for determination of hydroxyzine in plasma and its human pharmacokinetics.
An assay suitable for hydroxyzine determination in human plasma following therapeutic doses was developed. The method involves GLC and chemical-ionization mass spectrometry of the acetate derivatives of hydroxyzine and of a pentadeuterated analog internal standard. Following administration of 100-mg single oral doses to normal male volunteers, peak plasma concentrations of approximately 80 ng/ml were observed; the half-life of drug removal was approximately 3 hr.
D006207:Half-Life; D006801:Humans; D006919:Hydroxyzine / Q000097:blood*; D007408:Intestinal Absorption; D007700:Kinetics; D008297:Male; D008722:Methods
D006919:Hydroxyzine