title: 4-Acetoxy-1,2,3,4-tetrahydro-2,2-dimethyl-6,7-methylenedioxyisoquinolinium iodide, an acetylcholine analog.
abstract: 4-Acetoxy-1,2,3,4-tetrahydro-2,2-dimethyl-6,7-methylenedioxyisoquinolinium iodide, an analog of acetylcholine, was synthesized and a pharmacological profile of its GI effects was compiled. The agent inhibited dog colonic contraction in response to pelvic nerve stimulation and to acetylcholine. In rats, the compound markedly reduced gastric acid output and the volume of gastric secretions. The lack of inhibition of chromodacryorrhea production in response to carbachol indicates a lack of anticholinergic action. The agent failed to affect the acute inflammatory response of the rat hindpaw in response to carrageenan. The precursor of the compound was ineffective in the pharmacological tests.
mesh_terms: D000109:Acetylcholine / Q000031:analogs & derivatives*; D000818:Animals; D003106:Colon / Q000187:drug effects; D004285:Dogs; D066298:In Vitro Techniques; D007546:Isoquinolines / Q000138:chemical synthesis / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010276:Parasympatholytics; D011806:Quinolinium Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats
chemical_list: C022117:4-acetoxy-1,2,3,4-tetrahydro-2,2-dimethyl-6,7-methylenedioxyisoquinolinium iodide; D007546:Isoquinolines; D010276:Parasympatholytics; D011806:Quinolinium Compounds; D000109:Acetylcholine