Ischemic damage of the liver. Part II: In vivo investigation of the prevention of the ischemic lesion of the liver.
A new model for the study of ischemic liver lesion on rats has been worked out. Pretreatment with allopurinol, dibenzyline, methylprednisolone, glucagon, ATP-MgCl2 and aspartic acid reduced the overall mortality of ischemic liver injury. Administered after the anoxic hepatic lesion only glucagon and aspartic acid had beneficial effect on the survival rate. Under the influence of 30 minutes of normothermal ischemia the DNA synthetizing ability of the liver decreased. Aspartic acid, glucagon and ATP-MgCl2 significantly enhanced the regeneration of the ischemically damaged liver. These procedures might be suitable for donor pretreatment in liver transplantation, as well as for the treatment of other pathological states, causing a normothermal ischemia of the liver.
D000255:Adenosine Triphosphate / Q000627:therapeutic use; D000493:Allopurinol / Q000627:therapeutic use; D000818:Animals; D001224:Aspartic Acid / Q000627:therapeutic use; D002712:Chlorides / Q000627:therapeutic use; D005934:Glucagon / Q000627:therapeutic use; D007511:Ischemia / Q000401:mortality / Q000517:prevention & control*; D008099:Liver / Q000098:blood supply*; D008115:Liver Regeneration; D008274:Magnesium / Q000627:therapeutic use; D008775:Methylprednisolone / Q000627:therapeutic use; D010643:Phenoxybenzamine / Q000627:therapeutic use; D051381:Rats
D002712:Chlorides; D010643:Phenoxybenzamine; D001224:Aspartic Acid; D000493:Allopurinol; D000255:Adenosine Triphosphate; D005934:Glucagon; D008274:Magnesium; D008775:Methylprednisolone