title: Lipid composition of Morris hepatoma 5123c, and of livers and blood plasma from host and normal rats.
abstract: The lipid composition of Morris hepatoma 5123c was analyzed together with that of liver and blood plasma from both normal and tumor-bearing rats. The results showed that the liver of tumor-bearing rats contained higher amounts of glycerides, choelsteryl esters, free fatty acids and phospholipids than the liver of normal rats. In the blood plasma of tumor-bearing rats, there was an increase of free cholesterol and triglycerides; this latter difference, however, was not statistically significant. Acyl chain changes in the liver of tumor-bearing rats consisted of an increase of palmitic and oleic acids and a decrease of stearic and arachidonic acids in phosphatidylinositol. Morris hepatoma 5123c contained a lower amount of triglycerides than the livers (both host and normal) and showed a significant decrease of total phospholipids when compared to the host liver. The major acyl chain changes found in Morris hepatoma 5123c compared with both normal and host rat livers were: a) a higher percentage of arachidonic acid together with a lower proportion of palmitic acid in cholesteryl esters; b) an increase of stearic and arachidonic acids and a decrease of palmitic acid in triglycerides; and c) a higher level of palmitic and oleic acids associated with a lower percentage of stearic and C22 polyunsaturated acids in phosphatidylcholine.
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000032:analysis; D002788:Cholesterol Esters / Q000032:analysis; D004075:Diglycerides / Q000032:analysis; D005230:Fatty Acids, Nonesterified / Q000032:analysis; D005989:Glycerides / Q000032:analysis; D008055:Lipids / Q000032:analysis* / Q000097:blood; D008099:Liver / Q000032:analysis*; D008114:Liver Neoplasms, Experimental / Q000032:analysis*; D008297:Male; D010743:Phospholipids / Q000032:analysis / Q000097:blood; D051381:Rats; D014280:Triglycerides / Q000032:analysis
chemical_list: D002788:Cholesterol Esters; D004075:Diglycerides; D005230:Fatty Acids, Nonesterified; D005989:Glycerides; D008055:Lipids; D010743:Phospholipids; D014280:Triglycerides; D002784:Cholesterol