[Disorders in the murine chromosome apparatus induced by immunization with a complex of antiviral vaccines].
Immunization of mice with a number of live virus vaccines (poliovaccine, smallpox vaccine, measles vaccine) given consecutively at 14-day intervals resulted in increased frequency of chromosomal aberrations in bone marrow cells of the animals after the completion of the entire vaccination course (14 and 30 days after the last vaccination). Measles vaccine and, particularly, smallpox vaccine exert a significant harmful effect on the karyotype of the bone marrow cells. The effect on the chromosomes of the vaccines given consecutively differs somewhat from the individual effect of each of them.
D000818:Animals; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects*; D007114:Immunization; D008458:Measles Vaccine / Q000008:administration & dosage; D051379:Mice; D011054:Poliovirus Vaccine, Inactivated / Q000008:administration & dosage; D012900:Smallpox Vaccine / Q000008:administration & dosage; D013997:Time Factors; D014765:Viral Vaccines / Q000009:adverse effects*
D008458:Measles Vaccine; D011054:Poliovirus Vaccine, Inactivated; D012900:Smallpox Vaccine; D014765:Viral Vaccines
Narusheniia v khromosomnom apparate mysheĭ, vyzvannye immunizatsieĭ kompleksom protivovirusnykh vaktsin.