Inhibitors of renin and their utility in physiologic studies.
The enzyme renin is the initiator of a series of steps that ultimately leads to the generation of angiotensin II, a potent pressor peptide that also has both a direct and indirect role in renal sodium conservation. Renin's action on its protein substrate, angiotensinogen, is inhibited by specific antibody, a peptide produced by actinomyces, pepstatin and its derivatives, and by peptide analogs of a segment of the endogenous substrate. These inhibitors vary considerably in specificity, inhibitory constant, and utility for in vivo studies.
D000937:Antigen-Antibody Reactions; D007700:Kinetics; D009842:Oligopeptides / Q000494:pharmacology; D010436:Pepstatins / Q000494:pharmacology; D010743:Phospholipids / Q000494:pharmacology; D012083:Renin / Q000276:immunology / Q000378:metabolism; D012995:Solubility; D013329:Structure-Activity Relationship; D013379:Substrate Specificity; D000092502:Renin Inhibitors
D009842:Oligopeptides; D010436:Pepstatins; D010743:Phospholipids; D012083:Renin; D000092502:Renin Inhibitors