Re-evaluation of CHANDS.
A rare ectodermal dysplasia with the acronym CHANDS (Curly Hair, Ankyloblepharon, Nail Dysplasia Syndrome) was described by Baughman (1971) as being a new autosomal dominant condition. Additional pedigree data obtained after the original report indicate that the mode of inheritance is more likely to be autosomal recessive, with an instance of quasi-dominant transmission as a result of multiple consanguineous matings in the family. These data are provided in this report.
D001260:Ataxia Telangiectasia / Q000150:complications / Q000235:genetics; D002648:Child; D005143:Eyelids / Q000002:abnormalities*; D005260:Female; D006197:Hair / Q000002:abnormalities*; D006801:Humans; D008297:Male; D009264:Nails, Malformed; D010375:Pedigree; D013577:Syndrome