An unusual case of carbamazepine poisoning with a near-fatal relapse after two days.
A severe case of carbamazepine is described in which the drug and its major metabolite were monitored by means of HPLC. After two days of treatment a dramatic rise in plasma concentration of carbamazepine and its metabolite was observed, accompanied by a relapse into deep coma, then followed by a rapid elimination of the drugs and complete recovery within 4 days. The possible mechanisms underlying these phenomena and potential therapeutic measures are being discussed.
D000328:Adult; D002220:Carbamazepine / Q000097:blood / Q000506:poisoning*; D005260:Female; D006801:Humans; D013997:Time Factors
D002220:Carbamazepine