title: Etomidate and plasma esterase activity in man and experimental animals.
abstract: No hydrolysis of etomidate in plasma in vitro was detected in samples from man, horse, cow, sheep, guinea pig or white rabbit. Brown rabbits showed a moderate degree of hydrolysis and it was marked in plasma from Wistar rats. In this species, a single enzyme, an alliesterase, participated in the hydrolysis in plasma. Etomidate did not interfere with the hydrolysis of procaine by plasma pseudocholinesterase in man.
mesh_terms: D000818:Animals; D002417:Cattle; D002802:Cholinesterases / Q000097:blood; D004950:Esterases / Q000097:blood*; D005045:Etomidate / Q000097:blood*; D006168:Guinea Pigs; D006207:Half-Life; D006736:Horses; D006801:Humans; D006868:Hydrolysis; D007093:Imidazoles / Q000097:blood*; D008297:Male; D011817:Rabbits; D051381:Rats; D012756:Sheep
chemical_list: D007093:Imidazoles; D004950:Esterases; D002802:Cholinesterases; D005045:Etomidate