title: Circadian organization in Aplysia californica.
abstract: Substantial progress has been made in unraveling the organization of the circadian system of Aplysia californica. There are at least three circadian pacemakers in Aplysia. One has been localized in each eye and a third lies outside the eyes. Removal of the eyes disrupts the free-running locomotor activity rhythm; however, an extraocular oscillator can mediate a free-running rhythm in some eyeless animals. Although photoreceptors sufficient for entrainment of the ocular oscillator have been localized in the retina, photoreceptors outside the eyes are capable of "driving" a diurnal rhythm of locomotor activity and may also influence entrainment of ocular pacemakers. Finally, attention has been focused on the optic nerve as a coupling pathway between various parts of the system. The evidence suggests that information transmitted in the optic nerves is involved in entrainment of the ocular pacemaker by light, and in ocular control of the locomotor activity rhythm.
mesh_terms: D000200:Action Potentials; D000818:Animals; D001048:Aplysia / Q000502:physiology*; D001683:Biological Clocks; D002940:Circadian Rhythm; D005123:Eye / Q000294:innervation; D008027:Light; D009043:Motor Activity / Q000502:physiology; D009799:Ocular Physiological Phenomena; D009900:Optic Nerve / Q000502:physiology; D010786:Photoreceptor Cells / Q000502:physiology