Theoretical of the measurement of choroidal blood flow using a radioactive inert gas clearance technique.
A mathematical model for the diffusion of krypton in ocular tissues and its removal by blood flow has been developed to explain the complex clearance pattern found experimentally in the rabbit--an animal which has predominantly a choroidal circulation. Comparison of theoretical and experimental results has shown that the initial slope of the clearance curve is a measure of choroidal blood flow for values of blood flow over 500 ml/100 g/min. The shape of the curve at later times has been shown to be attributable predominantly to the diffusion of krypton into other ocular tissues.
D000818:Animals; D002829:Choroid / Q000098:blood supply*; D004058:Diffusion; D007726:Krypton; D008433:Mathematics; D008954:Models, Biological; D011817:Rabbits; D011868:Radioisotopes; D012039:Regional Blood Flow
D011868:Radioisotopes; D007726:Krypton