Plasma renin concentration and phenobarbital levels in patients with epilepsy.
Plasma renin activity, renin concentration, and renin substrate were measured in patients on long-term anticonvulsant medication. An inverse correlation was observed between phenobarbital levels and renin activity or concentration. There was a positive correlation between phenobarbital and renin substrate. Since elevation of renin substrate should have resulted in increased renin activity, it is possible that phenobarbital exerts 2 effects on the renin system: induction of renin substrate synthesis and suppression of renin release.
D000293:Adolescent; D000328:Adult; D000808:Angiotensinogen / Q000097:blood; D004827:Epilepsy / Q000097:blood* / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010634:Phenobarbital / Q000097:blood* / Q000627:therapeutic use; D012083:Renin / Q000097:blood*
D000808:Angiotensinogen; D012083:Renin; D010634:Phenobarbital