Daunorubicin-DNA and doxorubicin-DNA. A review of experimental and clinical data.
Experimental data on the pharmacokinetic, toxic and therapeutic properties of daunorubicin-DNA and doxorubicin-DNA complexes are reviewed and summarized as well as the available reports on clinical trials performed with these anthracycline-DNA complexes. These results are discussed in view of the further development of the drug-carrier concept of cancer chemotherapy.
D000818:Animals; D004247:DNA / Q000627:therapeutic use*; D003630:Daunorubicin / Q000378:metabolism / Q000627:therapeutic use* / Q000633:toxicity; D004317:Doxorubicin / Q000627:therapeutic use* / Q000633:toxicity; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*
D004317:Doxorubicin; D004247:DNA; D003630:Daunorubicin