Role of the pituitary and the adrenals in mediating the effects of alcohol on testicular steroidogenesis in mice.
We have previously demonstrated that intragastric administration of alcohol (1.24 g/kg body wt) to adult male mice results in suppression of testosterone production. We now report that the decline in peripheral testosterone levels in alcohol-treated mice is not accompanied by changes in plasma levels of luteinizing hormone, follicle stimulating hormone or estradiol-17 beta, and that it is markedly attenuated in adrenalectomized or adrenalectomized-corticosterone treated males.
D000311:Adrenal Glands / Q000502:physiology*; D000315:Adrenalectomy; D000818:Animals; D003345:Corticosterone / Q000494:pharmacology; D004958:Estradiol / Q000097:blood; D000431:Ethanol / Q000494:pharmacology*; D005640:Follicle Stimulating Hormone / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D051379:Mice; D010902:Pituitary Gland / Q000502:physiology*; D013737:Testis / Q000378:metabolism*; D013739:Testosterone / Q000097:blood*
D000431:Ethanol; D013739:Testosterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D003345:Corticosterone