Inhibition of influenza C virus replication by actinomycin D, alpha-amanitin, and UV irradiation.
Actinomycin D and alpha-amanitin caused similar reductions in the yields of influenza A/WSN and influenza C/JBH/1/66 viruses in a chicken kidney cell culture system. Irradiation of host cells with UV light before virus infection also produced a similar reduction in yields of the two viruses. The results indicate a close similarity between the replication processes of influenza C and other orthomyxoviruses.
D000546:Amanitins / Q000494:pharmacology*; D000818:Animals; D002460:Cell Line; D002645:Chickens; D003609:Dactinomycin / Q000494:pharmacology*; D009980:Influenza A virus / Q000254:growth & development; D007668:Kidney; D009975:Orthomyxoviridae / Q000254:growth & development*; D010452:Peptide Biosynthesis; D014466:Ultraviolet Rays; D014764:Viral Proteins / Q000096:biosynthesis
D000546:Amanitins; D014764:Viral Proteins; D003609:Dactinomycin