title: Effect of oil mists on the irritancy of sulfur dioxide. I. Mineral oils and light lubricating oil.
abstract: The increase in pulmonary flow resistance in unanesthetized guinea pigs was used to assess the effect of sub-micrometer oil aerosols on the response to sulfur dioxide. At a concentration of about 10 mg/m3 neither a medicinal grade mineral oil nor a light lubricating oil altered the response when given simultaneously with 1 or 10 ppm sulfur dioxide. The naphthenic medicinal oil at 100 mg/m3 failed to protect against 50 ppm sulfur dioxide when administerd simultaneously. A 30-minute pre-exposure, however, conferred complete protection. A paraffinic laboratory grade mineral oil conferred protection when given simultaneously but was less effective when the pre-exposure protocol was used.
mesh_terms: D000336:Aerosols; D000403:Airway Resistance / Q000187:drug effects*; D000818:Animals; D006168:Guinea Pigs; D007509:Irritants; D008899:Mineral Oil / Q000494:pharmacology*; D009821:Oils / Q000494:pharmacology*; D013458:Sulfur Dioxide / Q000009:adverse effects*
chemical_list: D000336:Aerosols; D007509:Irritants; D009821:Oils; D013458:Sulfur Dioxide; D008899:Mineral Oil