Importance of microcirculatory alterations in the initial hypertensive, oligoanuric phase of acute post-infective glomerulonephritis in infancy.
By applying the blood gas analysis to the venous blood of 17 children affected by DPGN, the authors have observed an increase of the PvO2 and a reduction of the PvCO2 in the oligoanuric and hypertensive phase, which is attributed to a minor utilization of O2. The authors relate a probable cellular respiratory defect with the initial skin tumefaction in these cases. This respiratory dysfunction would be due to intravascular red cell aggregation, to the reduction of perfusion of the exchange vessels and to the passage of the blood through preferential circuits.
D000208:Acute Disease; D000293:Adolescent; D001002:Anuria / Q000097:blood*; D001784:Blood Gas Analysis; D001794:Blood Pressure; D002648:Child; D002675:Child, Preschool; D004903:Erythrocyte Aggregation / Q000097:blood / Q000503:physiopathology; D005921:Glomerulonephritis / Q000097:blood*; D006801:Humans; D006973:Hypertension / Q000097:blood*; D007668:Kidney / Q000098:blood supply*; D008833:Microcirculation; D009846:Oliguria / Q000097:blood*