[Transformation of the epithelial cells of the kidney tubules in experimental malacoplakia].
As an effect of administration of the extract of E. coli in the kidney of rats phagolysosomal reaction has been observed, not only in the granulomatous tissue characteristic of malacoplakia, but in the epithelial cells of the proximal tubules. The latter became similar to the histiocytes of malacoplakis i.e. Hansemann's cells. The transformation of the tubular epithelium in severe cases of malacoplakia was followed by necrosis. In a later phase tubular atrophy came into being, which did not differ from the atrophy caused by other agents, although epithelial cells contained numerous residual body. Authors believe, that granular tubular cells of megalocytic interstitial nephritis--regarded as malacoplakia of the renal cortex--originate from tubular epithelium.
D000818:Animals; D004847:Epithelial Cells; D004848:Epithelium / Q000473:pathology; D007684:Kidney Tubules / Q000473:pathology*; D008287:Malacoplakia / Q000473:pathology*; D051381:Rats
A vesecsatornahám átalakulása kísérletes malakoplakiában.