title: Reappraisal of intravenous procaine as a short-acting anesthetic adjuvant.
abstract: Our data in 74 patients demonstrate that procaine hydrochloride is a safe anesthetic adjuvant in doses of 1 mg/kg/min even when total doses are 5 to 7 g. Blood pressure, heart rate, electrocardiographic variables, and blood gases were not adversely affected. Patients had no nausea or untoward postanesthesia symptoms. Emergence from anesthesia was rapid, within less than 15 minutes in all patients, and most were fully awake before leaving the operating room. In two patients in whom blood levels were studied the drug disappeared within 40 minutes. Procaine is inexpensive, $1.16 for 10 g, and it is not a known liver or kidney toxin. Until studies on cardiovascular dynamics and analgesic effects as in whom a low plasma cholinesterase activity is present or suspected. The clinical appraisal in 56 patients indicates its usefulness in suppressing premature venticular contractions and cough reflexes during endoscopic procedures in the respiratory tract. Procaine can be used to advantage in supplementing general anesthesia in outpatient surgery because of its brief action. For these reasons, the drug merits further study.
mesh_terms: D000293:Adolescent; D000328:Adult; D000777:Anesthetics; D001145:Arrhythmias, Cardiac / Q000517:prevention & control; D001784:Blood Gas Analysis; D001999:Bronchoscopy; D002648:Child; D003371:Cough / Q000517:prevention & control; D004334:Drug Administration Schedule; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007044:Hysterectomy; D007275:Injections, Intravenous; D008297:Male; D011343:Procaine / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology
chemical_list: D000777:Anesthetics; D011343:Procaine