[Investigations into the hormonal regulation of the corpus luteum function in the human (author's transl)].
In estradiol micro-crystalline suspension was injected into the ovary containing the corpus luteum in women who underwent hysterectomy. The same complete luteaolysis is in women who did not have hysterectomies was obtained. The conclusion is drawn that the prostaglandins which are formed in the uterus have no influence in man on the regulation of the survival of the corpus luteum. As far as we know to date the high excretion of estradiol from the corpus luteum during the maturation of the corpus luteum forms an internal shuttle mechanisms for the survival of the corpus luteum which inhibits the biosynthesis of progesterone by estrogen and blocks the effect of the gonadatropins on the granulosa cells.
D000328:Adult; D003338:Corpus Luteum / Q000502:physiology*; D004958:Estradiol; D005260:Female; D006107:Granulosa Cells; D006801:Humans; D007044:Hysterectomy; D003341:Luteolysis; D011374:Progesterone / Q000096:biosynthesis; D011453:Prostaglandins / Q000494:pharmacology; D014599:Uterus / Q000378:metabolism
D011453:Prostaglandins; D011374:Progesterone; D004958:Estradiol
Untersuchungen über die hormonale Regulation der Corpus-luteum-Funktion beim Menschen.