title: [Synthesis and properties of insulin modified on phenylalanine of chain B].
abstract: Lysyl and tetralysyl derivatives of insulin on phenylalanine of chain B were synthesized. The effects of modifications on the spatial structure and biological properties of the hormone were studied. It was found that an increase in the length of the modifier leads to a distortion of the hormone spatial structure resulting in a decrease of its biological activity.
mesh_terms: D007328:Insulin / Q000031:analogs & derivatives*; D008239:Lysine; D009842:Oligopeptides; D010649:Phenylalanine; D011487:Protein Conformation; D013329:Structure-Activity Relationship
chemical_list: D007328:Insulin; D009842:Oligopeptides; D010649:Phenylalanine; D008239:Lysine
vernacular_title: Sintez i izuchenie insulina modifitsirovannogo po fenilalaninu tsepi B.