4-Demethoxy-4-alkoxydaunorubicins.
The synthesis and the antitumor activities of a group of 4-demethoxy-4-alkoxydaunorubicins (VIII) are reported. The new compounds were found to have an activity equal or superior to that of daunorubicin, at somewhat higher doses.
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D003630:Daunorubicin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000627:therapeutic use; D007942:Leukemia, Experimental / Q000188:drug therapy*; D051379:Mice
D000970:Antineoplastic Agents; D003630:Daunorubicin