[Effect of D,L-malic acid dibenzylhydrazide on changes in the antioxidizing activity of lipids and monoamine oxidase activity in mouse organs].
Administration of dibenzylhydracide of D,L-malic acid (inhibitor of monoamine oxidase) into animals caused not only inhibition but also transformation of the mitochondrial monoamine oxidase activity, which acquired the property to deaminate histamine. Effect of the monoamine oxidase inhibitor on the antioxidative activity of lipids from mouse liver and brain tissues was studied. Effect of the dose administered and of the period of its action after administration were characterized. Influence of the inhibitor on oxidation of methyloleate was also studied in a model system. The data obtained suggest that the transformation-producing effect of the substance was not related to its immudiate action on the enzyme molecule but was apparently due to its influence on the intensity of lipid peroxidation in membranes.
D000818:Animals; D001921:Brain / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation / Q000187:drug effects; D005260:Female; D005609:Free Radicals; D066298:In Vitro Techniques; D008054:Lipid Peroxides / Q000378:metabolism; D008055:Lipids / Q000037:antagonists & inhibitors*; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D008928:Mitochondria / Q000378:metabolism; D008995:Monoamine Oxidase / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D009829:Oleic Acids / Q000378:metabolism; D010084:Oxidation-Reduction; D013997:Time Factors
D005609:Free Radicals; D008054:Lipid Peroxides; D008055:Lipids; D008996:Monoamine Oxidase Inhibitors; D009829:Oleic Acids; D008995:Monoamine Oxidase
Izmenenie antiokislitel'noĭ aktivnosti lipidov organov mysheĭ i aktivnosti monoaminokisdazy pri deĭstvii dibenzilgidrazida D,L-iablochnoĭ kisloty.