Comparison of carcinogenicity studies with aldrin and dieldrin.
Laboratory testing of animals is the principal method used to identify chemical carcinogens. However conflicting results are often obtained. This is emphasized in a cross-comparison of 6 aldrin-dieldrin studies; 3 were positive for tumor induction and 3 were negative. Four components of the assays are examined: husbandry, compound administration, observation, and interpretation of results.
D000452:Aldrin / Q000008:administration & dosage / Q000633:toxicity*; D000822:Animal Husbandry; D000818:Animals; D002273:Carcinogens; D004026:Dieldrin / Q000008:administration & dosage / Q000633:toxicity*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D051379:Mice; D051381:Rats; D012107:Research Design
D002273:Carcinogens; D004026:Dieldrin; D000452:Aldrin