title: Topographical distribution of arsenic, manganese, and selenium in the normal human brain.
abstract: The concentrations of arsenic, manganese and selenium per gram wet tissue weight were determined in samples from 24 areas of normal human brain from 5 persons with ages ranging from 15 to 81 years of age. The concentrations of the 3 elements were determined for each sample by means of neutron activation analysis with radiochemical separation. Distinct patterns of distribution were shown for each of the 3 elements. Variations between individuals were found for some but not all brain areas, resulting in coefficients of variation between individuals of about 30% for arsenic, 10% for manganese and 20% for selenium. The results seem to indicate that arsenic is associated with the lipid phase, manganese with the dry matter and selenium with the aqueous phase of brain tissue.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001151:Arsenic / Q000032:analysis*; D001923:Brain Chemistry; D005260:Female; D006801:Humans; D008297:Male; D008345:Manganese / Q000032:analysis*; D008875:Middle Aged; D009501:Neutron Activation Analysis; D012643:Selenium / Q000032:analysis*
chemical_list: D008345:Manganese; D012643:Selenium; D001151:Arsenic