Development and testing of new hypoxic cell radiosensitizers.
Several new electron-affinic compounds have been shown to possess radiosensitizing ability in hypoxic mammalian cells. The correlation between chemical structure and biological activity can aid in the design and synthesis of new agents with potentially greater hypoxic cell radiosensitizing ability.
D000818:Animals; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D006224:Cricetinae; D004307:Dose-Response Relationship, Radiation; D005347:Fibroblasts / Q000187:drug effects / Q000528:radiation effects; D008168:Lung; D008795:Metronidazole / Q000494:pharmacology; D008920:Misonidazole / Q000494:pharmacology; D009369:Neoplasms / Q000188:drug therapy; D010100:Oxygen; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D011838:Radiation-Sensitizing Agents; D008795:Metronidazole; D008920:Misonidazole; D010100:Oxygen