1,2-Dialkyl-4-pyrazolidinethiols as potential antiradiation agents.
The reaction between 3-chloropropylene sulfide and the 1,2-dialkylhydrazines was employed to prepare a series of 1,2-dialkyl-4-pyrazolidinethiols. Evidence is presented to support the structure proposed for the product. These mercaptoheterocycles are related to the beta-mercaptoethylamines and were prepared as potential radiation protective agents. No significant activity was observed.
D000818:Animals; D051379:Mice; D011720:Pyrazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D011837:Radiation-Protective Agents / Q000138:chemical synthesis; D013438:Sulfhydryl Compounds / Q000494:pharmacology
D011720:Pyrazoles; D011837:Radiation-Protective Agents; D013438:Sulfhydryl Compounds