Gentamicin penetration and decay in the human aqueous.
The penetration of gentamicin into human aqueous was measured after intensive drops or subconjunctival injection of the antibiotic. The drop regimen proved ineffective in producing a therapeutically effective level. After a single 40 mg subconjunctival injection an effective concentration was achieved in 2 hours and maintained for 24 hours. The significance of these findings is discussed with respect to therapeutic implications.
D000287:Administration, Topical; D000368:Aged; D001082:Aqueous Humor / Q000032:analysis / Q000378:metabolism*; D001702:Biopharmaceutics; D002387:Cataract Extraction; D003228:Conjunctiva; D005260:Female; D005839:Gentamicins / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D007267:Injections; D007700:Kinetics; D008297:Male; D008875:Middle Aged
D005839:Gentamicins