Inhibition by tryptophan of nucleolar RNA synthesis in salivary gland nuclei of Chironomus thummi.
Tryptophan, but not glutamine and lysine, inhibits the incorporation of 3H-uridine into nucleoli of explanted salivary glands by about 60%. In isolated nuclei also, the nucleolar incorporation of 3H-uridine triphosphate is reduced to about 50% by tryptophan. It is concluded that tryptophan acts directly at the nuclear level and the possible mechanisms.
D000818:Animals; D002466:Cell Nucleolus / Q000187:drug effects / Q000378:metabolism*; D002467:Cell Nucleus / Q000378:metabolism; D004175:Diptera; D006651:Histocytochemistry; D012313:RNA / Q000096:biosynthesis*; D012469:Salivary Glands / Q000378:metabolism*; D014158:Transcription, Genetic / Q000187:drug effects; D014364:Tryptophan / Q000494:pharmacology*; D014529:Uridine / Q000378:metabolism
D012313:RNA; D014364:Tryptophan; D014529:Uridine