title: Time kinetics of the interaction of concanavalin A with splenic lymphocytes of normal AKR mice.
abstract: Interaction of concanavalin A (Con A) with splenic lymphocytes of normal AKR mice led to concentration-dependent biphasic changes in electrophoretic mobility. Kinetics of this interaction suggested that at high concentration Con A interacted in two steps. The first step led to redistribution of Con A receptors and increased EPM. In the second step additional receptors to Con A became accessible and their interaction with Con A reduced surface charge density. The kinetic data thus provide additional evidence for the existence of two sets of qualitatively different receptors for Con A on AKR lymphocytes.
mesh_terms: D000818:Animals; D003208:Concanavalin A / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004586:Electrophoresis; D005260:Female; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D008856:Microscopy, Fluorescence; D011952:Receptors, Concanavalin A / Q000187:drug effects; D013154:Spleen / Q000166:cytology; D013997:Time Factors
chemical_list: D011952:Receptors, Concanavalin A; D003208:Concanavalin A