Effect of hydrocortisone on the metabolism of phosphatidylcholine in maternal and fetal rabbit lungs and livers.
Administration of hydrocortisone to pregnant rabbits caused a decrease in weights of fetal body and lung and an increase in the incorporation of choline into fetal lung PC. The authors found no induction of the enzymes related to the incorporation of choline into PC in fetal lung. Also, there was no stimulation of any enzymatic activity of CDP-choline pathway or PC-lysoPC cycle pathway in maternal lung and liver or fetal liver. In addition to the acceleration of choline incorporation into fetal lung PC by the cortisol, hydrocortisone also significantly stimulated the secretion of lung PC affected by glucocorticoids may also be related to apparent fetal lung maturation.
D000818:Animals; D003566:Cytidine Diphosphate Choline / Q000378:metabolism; D005260:Female; D006854:Hydrocortisone / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000196:embryology / Q000201:enzymology / Q000378:metabolism; D008168:Lung / Q000187:drug effects* / Q000196:embryology / Q000378:metabolism; D008431:Maternal-Fetal Exchange; D010713:Phosphatidylcholines / Q000378:metabolism*; D011247:Pregnancy; D011817:Rabbits
D010713:Phosphatidylcholines; D003566:Cytidine Diphosphate Choline; D006854:Hydrocortisone