title: Morphological findings in granular reticulum of arcuate nucleus neurons after clomiphene citrate administration.
abstract: The action of high doses of clomiphene citrate on the rough endoplasmic reticulum of the hypothalamic arcuate neurons of male cat has been studied. Clomiphene (250 mg/kg) produces an accumulation of typical paracrystalline material in the rough endoplasmic reticulum. After the administration of a protein-synthesis inhibitor no such material was observed in clomiphene-treated cats. The possibility exists that the specific ultrastructural changes seen indicate an increased protein synthesis in hypothalamic arcuate neurons.
mesh_terms: D000818:Animals; D002415:Cats; D002996:Clomiphene / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004721:Endoplasmic Reticulum / Q000187:drug effects* / Q000648:ultrastructure; D007031:Hypothalamus / Q000187:drug effects* / Q000648:ultrastructure; D008297:Male; D008526:Medulla Oblongata / Q000648:ultrastructure; D009419:Nerve Tissue Proteins / Q000096:biosynthesis; D009474:Neurons / Q000187:drug effects*
chemical_list: D009419:Nerve Tissue Proteins; D002996:Clomiphene