title: Activation of vinyl chloride to covalently bound metabolites: roles of 2-chloroethylene oxide and 2-chloroacetaldehyde.
mesh_terms: D000079:Acetaldehyde / Q000031:analogs & derivatives* / Q000378:metabolism; D000429:Alcohol Oxidoreductases / Q000378:metabolism*; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004851:Epoxide Hydrolases / Q000378:metabolism*; D005027:Ethylene Oxide / Q000378:metabolism* / Q000031:analogs & derivatives; D007700:Kinetics; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D014752:Vinyl Chloride / Q000378:metabolism*; D014753:Vinyl Compounds / Q000378:metabolism*
chemical_list: D014753:Vinyl Compounds; C015061:chloroethylene oxide; D003577:Cytochrome P-450 Enzyme System; C004656:chloroacetaldehyde; D000429:Alcohol Oxidoreductases; D004851:Epoxide Hydrolases; D000079:Acetaldehyde; D005027:Ethylene Oxide; D014752:Vinyl Chloride; D010634:Phenobarbital