Interaction of metal ions with nucleic acids. Interaction of copper(II) with pyrimidine nucleosides and their derivatives.
1. In aqueous and non-aqueous solutions, copper(II) interacts with the N-3 of cytidine but not with the carbonyl group oxygens of pyrimidine nucleosides. 2. In aqueous solution, copper(II) interacts with the phosphate group and ribose of pyrimidine nucleotides, and additionally with N-3 of 5'-CMP. 3. Broadening of resonance signals of the H-5 proton of 5'-UMP and C-5 of 5'-UMP and 5'-TMP results probably from the interaction between metal ion and the phosphate group situated in direct vicinity of the above atoms. 4. In the copper(II)-pyrimidine nucleotide complexes in solid state, copper is coordinated with the phosphate group, and in 5'-CMP additionally with the pyrimidine moiety of the nucleotide.
D001665:Binding Sites; D003300:Copper; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D011741:Pyrimidine Nucleosides; D011742:Pyrimidine Nucleotides; D013055:Spectrophotometry, Infrared
D011741:Pyrimidine Nucleosides; D011742:Pyrimidine Nucleotides; D003300:Copper