Dermatomyositis associated with BCG vaccination.
Two young boys developed serious forms of dermatomyositis following BCG vaccination. Possibilities of a causal relationship between the disease and the vaccination are discussed. Extensive immunological tests, however, including in vitro stimulation of lymphocytes with PPD, gave no decisive evidence of abnormalities. It is concluded that in cases of dermatomyositis there is an absolute indication for a full anamnesis with regard to previous vaccination, to obtain clarification of the practical and theoretically important questions of a possible connection in this respect.
D000293:Adolescent; D001323:Autoantibodies / Q000032:analysis; D001500:BCG Vaccine / Q000009:adverse effects*; D003165:Complement System Proteins / Q000032:analysis; D003882:Dermatomyositis / Q000209:etiology* / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D008213:Lymphocyte Activation; D008297:Male
D001323:Autoantibodies; D001500:BCG Vaccine; D007136:Immunoglobulins; D003165:Complement System Proteins