A direct role of dopamine in the rat subthalamic nucleus and an adjacent intrapeduncular area.
The subthalamic nucleus, a clinically important component of the extrapyramidal motor system, and a lateral area extending into the peduncle contain catecholamine terminals and dopamine receptors coupled to adenylate cyclase. In addition, dopamine agonists administered in vivo enhance glucose utilization in the region. Thus, neuronal function in this region is directly affected by dopamine and dopaminergic drugs.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D001931:Brain Mapping; D002395:Catecholamines / Q000494:pharmacology; D004298:Dopamine / Q000494:pharmacology; D004789:Enzyme Activation / Q000187:drug effects; D005116:Extrapyramidal Tracts / Q000378:metabolism* / Q000648:ultrastructure; D005947:Glucose / Q000378:metabolism; D008297:Male; D008636:Mesencephalon / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism; D051381:Rats; D011954:Receptors, Dopamine / Q000378:metabolism*
D002395:Catecholamines; D011954:Receptors, Dopamine; D000262:Adenylyl Cyclases; D005947:Glucose; D004298:Dopamine