Tolmetin and G-6-PD erythrocyte deficiency: research in vitro.
In thirty-two patients, divided into four groups: normal, G-6-PD deficient, beta-thalaxemic heterozygote and carriers of both anomalies, the variations in erythrocyte GSH were studied after incubation with APH and a non-steroidal anti-inflammatory drug: tolmetin sodium. The results obtained show a considerable fall in GSH after incubation with APH above all in the G-6-PD deficient patients and in the carriers of both anomalies. On the other hand, after incubation with the drug under examination there were no significant variations in the erythrocyte GSH.
D000328:Adult; D000368:Aged; D003864:Depression, Chemical; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000097:blood* / Q000150:complications; D005978:Glutathione / Q000097:blood*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D011758:Pyrroles / Q000494:pharmacology*; D013789:Thalassemia / Q000097:blood / Q000150:complications; D014046:Tolmetin / Q000494:pharmacology*
D011758:Pyrroles; D014046:Tolmetin; D005978:Glutathione