title: Effect of hypophysectomy and growth hormone administration on somatostatin content in the rat hypothalamus.
abstract: The effect of hypophysectomy and bovine GH administration on somatostatin (SRIF) content in the rat hypothalamus was investigated. SRIF content was determined by a specific radioimmunoassay method described elsewhere. The total SRIF content of the rat hypothalamus as well as its content per milligram wet weight had decreased 4 weeks after hypophysectomy but was restored significantly in those rats which were subjected to bovine GH administration for 7 days 3 weeks after hypophysectomy. Furthermore, in nonoperated rats, increase of hypothalamic SRIF content was observed after 7 days GH administration. These results indicate that growth hormone may influence the SRIF content of hypothalamus and it seems likely that a feedback mechanism between pituitary GH and hypothalamic SRIF exists.
mesh_terms: D000818:Animals; D013006:Growth Hormone / Q000494:pharmacology*; D007016:Hypophysectomy; D007031:Hypothalamus / Q000187:drug effects*; D008297:Male; D051381:Rats; D013004:Somatostatin / Q000378:metabolism*
chemical_list: D013004:Somatostatin; D013006:Growth Hormone