[Activity of lactate dehydrogenase and glucose-6-phosphate dehydrogenase activity in rat testicular tissues after exposure to certain pesticides].
In experiments on male Wistar rats the action of organophosphorus pesticides (chlorophos and methylnitrophos) and cineb, belonging to compounds of the carbamine series, on the LDH and H-6-PDH of the testes tissues and their isoenzymatic spectra, was studied. The results of investigations demonstrated substantial changes in the activity of the LDH and H-6-PDH isoenzymes occurring with a long-term priming for 9 months of chlorophos in a dose of 1 mg/kg of the mass. On the other hand, with introduction of methylnitrophos (in a dose of 0.5 mg/kg mass) and cineb (in a dose of 2.5 mg/kg) no statistically significant changes in the activity of the LDH and H-6-PDH were in evidence. Introduction in the same doses of chlorophos, methylnitrophos and cineb for 3 months did not have any essential influence on the activity of the LDH and H-6-PDH isoenzyme fractions, nor on their isoenzymatic profile by comparison with controls.
D000818:Animals; D005278:Fenitrothion / Q000494:pharmacology; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism*; D007527:Isoenzymes / Q000378:metabolism*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D008297:Male; D010575:Pesticides / Q000494:pharmacology*; D051381:Rats; D013737:Testis / Q000201:enzymology*; D014236:Trichlorfon / Q000494:pharmacology; D015038:Zineb / Q000494:pharmacology
D007527:Isoenzymes; D010575:Pesticides; D014236:Trichlorfon; D007770:L-Lactate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D005278:Fenitrothion; D015038:Zineb
Aktivnost' izofermentov laktatdegidrogenazy i gliukozo-6-fosfatdegidrogenazy v tkaniakh semennikov krys pri vozdeĭstvii nekotorykh pestitsidov.