Leukocyte hexose monophosphate shunt activity during phagocytosis in vitamin B12 and folic acid deficiencies.
Little information exists about leukocytic function in megaloblastic anemia. A report of abnormal hexose monophosphate shunt and phagocytic activity only in vitamin B12 deficiency and not in folate deficiency prompted us to examine latex-stimulated hexose monophosphate shunt activity in the two conditions. Only two of our five patients with pernicious anemia demonstrated defective activation, while one of the two folate-deficient patients also had this defect. These findings clearly indicate that hexose monophosphate shunt activity is neither consistently impaired in vitamin B12 deficiency nor consistently unaffected in folate deficiency.
D000749:Anemia, Megaloblastic / Q000150:complications; D005494:Folic Acid Deficiency / Q000097:blood* / Q000150:complications; D006600:Hexosephosphates / Q000097:blood*; D006801:Humans; D009504:Neutrophils / Q000378:metabolism*; D010587:Phagocytosis; D014806:Vitamin B 12 Deficiency / Q000097:blood* / Q000150:complications
D006600:Hexosephosphates