Effect of deglycyrrhizinated liquorice on gastric mucosal damage by aspirin.
Gastric mucosal damage induced by giving 60 mg aspirin orally to rats was reduced by simultaneous administration of 100-500 mg deglycyrrhizinated liquorice. Human faecal blood loss induced by 975 mg aspirin orally three times a day was less when 350 mg deglycyrrhizinated liquorice was given with each dose of aspirin.
D000328:Adult; D000818:Animals; D001241:Aspirin / Q000008:administration & dosage; D004353:Drug Evaluation, Preclinical; D005753:Gastric Mucosa / Q000187:drug effects*; D006035:Glycyrrhiza; D006801:Humans; D008297:Male; D008875:Middle Aged; D010438:Peptic Ulcer Hemorrhage / Q000139:chemically induced / Q000517:prevention & control; D010936:Plant Extracts / Q000627:therapeutic use*; D010946:Plants, Medicinal; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000517:prevention & control
D010936:Plant Extracts; C005981:deglycyrrhizinized liquorice; D001241:Aspirin