Changes of electrolyte excretion, renin activity, angiotensin-II and aldosterone concentrations during administration of 3-amino-1-(3,4-dichloro-a-methyl-benzyl)-2-pyrazolin-5-one (Bay g 2821).
After the administration of 40 mg Bay g 2821, a new potent diuretic substance, a significant increase of sodium and water diuresis occurred. There was only a short rise in potassium excretion. In contrast to the sodium and water diuresis no significant increase of renin-activity, angiotensin-II or aldosterone concentration was seen. In spite of the insignificant stimulation of the renin-angiotensin-aldosterone system, a significant increase of correlation occurred between the three components of the renin-angiotensin-aldosterone system.
D000328:Adult; D000450:Aldosterone / Q000097:blood*; D000804:Angiotensin II / Q000097:blood*; D004573:Electrolytes / Q000652:urine*; D006801:Humans; D008297:Male; D009156:Muzolimine / Q000494:pharmacology*; D011188:Potassium / Q000097:blood; D011720:Pyrazoles / Q000494:pharmacology*; D012083:Renin / Q000097:blood*; D012964:Sodium / Q000097:blood; D013997:Time Factors
D004573:Electrolytes; D011720:Pyrazoles; D009156:Muzolimine; D000804:Angiotensin II; D000450:Aldosterone; D012964:Sodium; D012083:Renin; D011188:Potassium