Immunotherapy of a murine sarcoma using specific antitumor immune RNA.
The effect of IRNA therapy in a polyoma-induced fibrosarcoma of C3H mice has been studied. Although a protocol that transferred in vitro cytotoxicity was used, no reduction in incidence of tumors, tumor size, or survival was demonstrated. In one experiment, enhancement of tumor growth occurred. It is concluded that cytotoxicity does not reflect in vivo changes and that therapeutic trials of IRNA are premature.
D000818:Animals; D006168:Guinea Pigs; D007109:Immunity; D007116:Immunization, Passive; D007167:Immunotherapy; D017710:Lymphocyte Transfusion; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D012313:RNA / Q000276:immunology* / Q000627:therapeutic use*; D012513:Sarcoma, Experimental / Q000276:immunology / Q000628:therapy*; D014185:Transplantation, Isogeneic
D012313:RNA