Effect of immunochemotherapy on lymphocyte response of patients with gastrointestinal cancer.
Patients with gastrointestinal cancer were treated with 5-fluorouracil (5-FU) in combination with a streptococcal preparation, OK-432, or without OK-432 before operation, and lymphocyte response to PHA was examined. Oral administration of 5-FU with or without intramuscular injection of OK-432 did not affect the response. However, treatment with cytostatic drugs in combination with OK-432 markedly augmented the lymphocyte response to PHA, but the cytotoxic activity of lymphocytes was not elevated.
D001688:Biological Products / Q000627:therapeutic use*; D003601:Cytotoxicity Tests, Immunologic; D005472:Fluorouracil / Q000008:administration & dosage*; D005770:Gastrointestinal Neoplasms / Q000188:drug therapy / Q000276:immunology / Q000628:therapy*; D006801:Humans; D007167:Immunotherapy; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000276:immunology; D010835:Phytohemagglutinins / Q000494:pharmacology; D010844:Picibanil / Q000627:therapeutic use*
D001688:Biological Products; D010835:Phytohemagglutinins; D010844:Picibanil; D005472:Fluorouracil