A comparison of netilmicin and gentamicin in the treatment of pelvic infections.
Seventy-five women admitted with the symptom complex suggestive of pelvic inflammatory disease( PID) were started on a penicillin-aminoglycoside antibiotic regimen. An aminoglycoside, gentamicin or netilmicin (Schering-Plough), was chosen randomly and given parenterally. Forty-two patients received netilmicin and 33 received gentamicin for 5 days. Therapeutic response to the 2 antibiotic regimens was similar. Aminoglycosides have been associated with both nephrotoxicity and ototoxicity. Blood chemistries were studied in all patients. The only manifested toxicity was in 2 patients treated with gentamicin. Endometrial-endocervical cultures were obtained before and after therapy. The microbacteria isolated by standard culture techniques before therapy revealed Neisseria gonorrhoeae in 69% and 51% of the netilmicin and gentamicin groups, respectively; anaerobic organisms were cultured in about 75% of each group.
D000208:Acute Disease; D000328:Adult; D004359:Drug Therapy, Combination; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D009428:Netilmicin / Q000008:administration & dosage / Q000009:adverse effects; D000292:Pelvic Inflammatory Disease / Q000188:drug therapy*; D010400:Penicillin G / Q000008:administration & dosage / Q000009:adverse effects
D005839:Gentamicins; D009428:Netilmicin; D010400:Penicillin G