[Radiosensitization with metronidazole. Pharmacocinetical comparison by means of blood level curves after administration of "metronidazol" in the form of tablets, suppositories, and enemas (author's transl)].
Severe acute gastrointestinal side-effects following high oral doses of metronidazole (6 g/m2) could be avoided by a combined oral and rectal application. With tablets and an enema (1 g metronidazole/2 ml) in a ratio 1:4 and an increased dosage of 10 g/m2, maximal serum concentrations of about 200 micrograms/ml are obtained like after an oral dosage of 6 g/m2. The maximal radiosensitizing effect on hypoxic tumor cells is seen five hours after oral application and seven hours after the combined oro-rectal application. No longterm toxicity was found following six high doses of metronidazole.
D000284:Administration, Oral; D006801:Humans; D007700:Kinetics; D008795:Metronidazole / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism / Q000494:pharmacology*; D013488:Suppositories
D013488:Suppositories; D008795:Metronidazole
Strahlensensibilisierung mit Metronidazol. Pharmakokinetischer Vergleich an Hand von Blutspiegelkurven nach Verabreichung von Metronidazol in Form von Tabletten, Suppositorien und Klistier.