Amitriptyline: comparison of three different dosage schedules in neurotic depression.
Three groups of neurotic depressed patients were treated with amitriptyline, one group receiving the customary three daily doses, another a single dose in the morning, and the third a single dose at night. All three groups showed significant decrements of total scores on the Hamilton Scale for Depression and the Zung Self-Rating Depression Scale without significant differences. Patients taking the drug at night showed a lower incidence of side effects.
D000275:Adjustment Disorders / Q000188:drug therapy*; D000328:Adult; D000639:Amitriptyline / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D004334:Drug Administration Schedule; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D000639:Amitriptyline