title: Norepinephrine turnover in pineal gland and superior cervical ganglia. Changes after gonadotrophin administration to castrated rats.
abstract: The effects of FSH and LH on norepinephrine (NE) turnover in pineal gland and superior cervical ganglia of castrated female rats were examined by measuring the decline of [3H]NE concentration in the organ 30--120 min after a single i.v. injection of the labeled amine. Both FSH and LH treatment significantly decreased [3H]NE turnover in the pineal gland whereas only FSH accelerated it in the ganglia. As compared to controls, the initial uptake of [3H]NE was lower in the pineal gland of FSH- and LH-treated animals, and higher in the superior cervical ganglia of rats injected with FSH. Neither FSH nor LH modified [3H]NE turnover in heart or adrenal gland, nor changed their endogenous catecholamine content. Pineal monoamine oxidase (MAO) activity type B (assaying by using beta-phenylethylamine as substrate) was decreased by FSH or LH injection. Only FSH modified MAO activity in the ganglia by increasing significantly type A enzyme (assaying by using serotonin as substrate). These results suggest that FSH and LH affect significantly NE metabolism in pineal gland and superior cervical ganglia of spayed rats.
mesh_terms: D000311:Adrenal Glands / Q000378:metabolism; D000818:Animals; D002369:Castration; D005260:Female; D005640:Follicle Stimulating Hormone / Q000494:pharmacology*; D005728:Ganglia, Sympathetic / Q000378:metabolism*; D007986:Luteinizing Hormone / Q000494:pharmacology*; D008995:Monoamine Oxidase / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D010627:Phenethylamines / Q000378:metabolism; D010870:Pineal Gland / Q000378:metabolism*; D051381:Rats; D012701:Serotonin / Q000378:metabolism
chemical_list: D010627:Phenethylamines; D012701:Serotonin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D008995:Monoamine Oxidase