Fortimicins C, D and KE, new aminoglycoside antibiotics.
From the fermentation broth of Micromonospora olivoasterospora CS-26 that produced fortimicins A and B three new aminoglycoside antibiotics, fortimicins C, D and KE, were isolated. Fortimicins C and D exhibited potent, broad spectrum antibacterial activities against Gram-positive and negative bacteria, while fortimicin KE was only weakly active.
D000617:Aminoglycosides / Q000032:analysis / Q000096:biosynthesis / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000096:biosynthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D005285:Fermentation; D051379:Mice; D008847:Micromonospora / Q000378:metabolism
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents