title: Benzimidazole resistance of equine stronygles--critical tests of six compounds against population B.
abstract: Critical tests were conducted on eight horses naturally infected with several species of large and small strongyles from population B. Tested were six benzimidazoles, including thiabendazole (2 lots) (44 mg/kg of body weight); mebendazole (8.8 mg/kg); cambendazole (two formulations) (20 mg/kg); fenbendazole (10 mg/kg); oxibendazole (10 mg/kg); and oxfendazole (10 mg/kg). All compounds were administered by stomach tube except one of the two cambendazole formulations which was an intraoral paste. Removal of large strongyles (when present), Strongylus vulgaris and Strongylus edentatus, was 100% by each drug. In general, five species of small strongyles (Cyathostomum catinatum, Cyathostomum coronatum, Cylicocyclus nassatus, Cylicostephanus goldi, and Cylicostephanus longibursatus) exhibited varying degrees of resistance (% removal) to all of the drugs except oxibendazole. A total of 19 other species of small strongyles from seven genera, including the three described earlier were about 100% removed by the six benzimidazoles. Poor removal of immature (fourth-stage larvae) forms was also characteristic of the six drugs.
mesh_terms: D000818:Animals; D001562:Benzimidazoles / Q000627:therapeutic use*; D004352:Drug Resistance, Microbial; D005260:Female; D006734:Horse Diseases / Q000188:drug therapy*; D006736:Horses; D008297:Male; D013319:Strongyle Infections, Equine / Q000188:drug therapy*; D013320:Strongyloidea / Q000033:anatomy & histology
chemical_list: D001562:Benzimidazoles