Immune complex glomerulonephritis in chronic granulomatous disease. Case report of an eighteen-year-old girl.
An 18-year-old girl is described who developed advanced renal sclerotic lesions, probably preceded by local focal glomerulonephritis, which coexisted with a Staphylococcus aureus abscess. It is hypothesized that immune complex glomerulonephritis developed, provoked by long-term antigenic stimulation of Staphylococcus aureus. The cause of these long-term bacterial infections was a defect of the phagocytic cells to kill bacteria effectively, a disease known as chronic granulomatous disease. Therapy with intracellularly active antimicrobial agents restored the renal function till no more haemodialysis was necessary.
D000293:Adolescent; D002634:Chemotaxis, Leukocyte; D005260:Female; D005921:Glomerulonephritis / Q000150:complications / Q000276:immunology* / Q000473:pathology; D006105:Granulomatous Disease, Chronic / Q000150:complications*; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology; D009504:Neutrophils / Q000276:immunology / Q000378:metabolism; D012867:Skin / Q000473:pathology; D013203:Staphylococcal Infections / Q000150:complications*; D013211:Staphylococcus aureus