title: Cerebral blood flow, cerebrovascular resistance and cerebral metabolic rate of oxygen in severe arterial hypoxia in dogs.
abstract: Cerebral blood flow and cerebral oxygen uptake were studied during severe arterial hypoxia in anesthetized dogs. It was shown that the hypoxic vasodilatation in the brain reaches a limit at an arterial oxygen saturation at about 25% and that this vasodilatation is less than that which may be induced by hypercapnia. A further deepening of the arterial hypoxia at a maintained cerebral perfusion pressure is combined with a continuous decrease in cerebral venous oxygen tension and a reduced oxygen uptake.
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D002536:Cerebral Arteries / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D004108:Dilatation, Pathologic / Q000503:physiopathology; D004285:Dogs; D002534:Hypoxia, Brain / Q000378:metabolism / Q000503:physiopathology*; D010101:Oxygen Consumption; D014655:Vascular Resistance