[Biochemical analysis of the microvillose membranes of the small intestine mucosa of dogs after levorin administration].
The effect of oral levorin used for a prolonged period of time on the lipid composition and activity of alkaline phosphatase and invertase of the microvilli membranes of the small intestinal enterocytes of old dogs was studied. Higher ratios of cholesterol/phospholipids in the membranes and inactivation of alkaline phosphatase and invertase were noted in the old dogs as compared to the young ones. Exposure of the old dogs to levorin had a significant effect on the microvilli membranes of the intestinal epithelial cells. It was evident from a lower ratio of cholesterol/phospholipids in the membranes and stimulation of the alkaline phosphatase activity. It is supposed that the changes in the state of the microvilli membranes of the small intestinal mucosa due to levorin play a definite role in the mechanism of its hypercholesterolemic action.
D000375:Aging; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage*; D002174:Candicidin / Q000008:administration & dosage*; D002462:Cell Membrane / Q000032:analysis*; D004285:Dogs; D007413:Intestinal Mucosa / Q000187:drug effects / Q000648:ultrastructure*; D007421:Intestine, Small / Q000187:drug effects / Q000648:ultrastructure*; D008871:Microvilli / Q000032:analysis* / Q000187:drug effects; D013607:Tablets; D013997:Time Factors
D000935:Antifungal Agents; D013607:Tablets; D002174:Candicidin
Biokhmicheskii analiz membran mikrovorsinok slizistoĭ obolochki tonkogo kishechnika sobak posle vvedeniia levorina.