Effect of amphetamine on plasma corticosterone in the conscious rat.
The effect of amphetamine (AMPH) on plasma corticosterone was studied in the conscious, unstressed rat. AMPH (0.5-5.0 mg/kg) produced a dose-dependent increase in plasma corticosterone. This rise in plasma corticosterone was not altered by the adrenergic blocking agents phenoxybenzamine or propranolol. In contrast, the serotonergic depleting agent p-chloroamphetamine significantly inhibited the AMPH-induced rise in corticosterone. In addition, the serotonergic blocking agent methysergide, but not cyproheptadine, inhibited the corticosterone increase induced by AMPH.
D000661:Amphetamine / Q000494:pharmacology*; D000662:Amphetamines / Q000494:pharmacology*; D000818:Animals; D003345:Corticosterone / Q000097:blood*; D003533:Cyproheptadine / Q000494:pharmacology; D008297:Male; D010643:Phenoxybenzamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D010133:p-Chloroamphetamine / Q000494:pharmacology*
D000662:Amphetamines; D010643:Phenoxybenzamine; D003533:Cyproheptadine; D010133:p-Chloroamphetamine; D011433:Propranolol; D000661:Amphetamine; D003345:Corticosterone