Experimental traumatic cataract. I. A quantitative microradiographic study.
Traumatic cataract was induced in rat and rabbit. The progression of the posterior subcapsular cataract and the wound healing were followed by quantitative microradiography. This method makes it possible to determine the dry mass content and to calculate the refractive indices in the lens. In the injured rat lens a reduced dry mass concentration was determined in both the wound region and the posterior subcapsular region immediately after trauma. During the first week a subcapsular opacity was observed to enlarge. This opacification always corresponded to a reduction in the subcapsular concentration of dry mass. This reduced content of dry material, mainly consisting of protein, is interpreted as a hydration of the subcapsular cortex. In the rabbit lens a much larger injury had to be made in order to cause any posterior cataract. The same reduction in the content of dry material was determined in regions corresponding to opacitices but the reduction was less pronounced than in the rat lens. The border zones between different concentrations of dry mass are suggested to be the main sources of scattered light in the traumatic cataract.
D000818:Animals; D002386:Cataract / Q000000981:diagnostic imaging* / Q000209:etiology / Q000473:pathology; D007908:Lens, Crystalline / Q000000981:diagnostic imaging / Q000293:injuries* / Q000473:pathology; D008297:Male; D011817:Rabbits; D011859:Radiography; D051381:Rats; D014945:Wound Healing