[Biological parameters of a standardized tumor model for chemotherapeutical and toxicological testing (author's transl)].
Biological parameters for standardization of the syngeneic i.m. transplanted ascitic sarcoma 276A in the mouse inbred strain XVII Berlin are described. As therapeutical criteria of cytostatic treatment are used the increase in lifespan of the experimental animals and the parameter E, which results from a growth kinetics obeying a Gompertz function. For estimation of the effect on other quickly proliferating tissues were determined: leukocytes, thrombocytes, reticulocytes, hemoglobin and differentiation of leukocytes. These parameters can serve for the evaluation of pharmacological effectiveness of a cytostatic agent, as shown by the example of a treatment with cyclophosphamide in two different dosages.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001772:Blood Cell Count; D003520:Cyclophosphamide / Q000008:administration & dosage; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical / Q000379:methods; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation; D012513:Sarcoma, Experimental / Q000097:blood / Q000188:drug therapy* / Q000401:mortality; D014185:Transplantation, Isogeneic
D000970:Antineoplastic Agents; D003520:Cyclophosphamide
Biologische Parameter eines standardisierten Tumormodells für chemotherapeutische und toxikologische Untersuchungen.