[New therapeutic prospects in lead poisoning: alpha-mercaptopropionylglycine].
The action of alpha-mercaptopropionylglycine has been studied in 27 subjects occupationally exposed to lead. In addition to improved efficiency of liver function, the results show a tendency to normalization of the various porphyrinic metabolism parameters considered. A significant increase was observed in erythrocyte dehydratase ALA activity together with an equally significant diminution in urinary excretion of delta-aminoleuvlinic acid. Urinary coprorphyrin and erythrocyte protoporphyrin IX values were also down. The tendency of metabolic changes to normalize as a result of the toxic action of lead suggests the use of alpha-mercaptopropionylglycine in the treatment of lead poisoning.
D000328:Adult; D000603:Amino Acids, Sulfur / Q000627:therapeutic use*; D004341:Drug Evaluation; D006801:Humans; D007263:Infusions, Parenteral; D007855:Lead Poisoning / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D008625:Tiopronin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
D000603:Amino Acids, Sulfur; D008625:Tiopronin
Nuove prospettive terapeutiche nell'intossicazione da piombo: l'alpha-mercaptopropionilglicina.