Althesin for neuroanaesthesia.
Althesin was used as a induction agent then diluted and administered as a controlled infusion for 60 patients undergoing 66 procedures. Increment doses of fentanyl were given to provide additional analgesia. There was delayed awakening in 7 patients (12.1%), 3 of whom responded rapidly to narcotic reversal with naloxone. Intracerebral pathology and surgical trauma contributed to the slow recovery in the other 4 patients. Evidence is presented that Althesin infusions reduce the narcotic requirement. Althesin anaesthesia provides good neurosurgical conditions without delay in recovery.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000530:Alfaxalone Alfadolone Mixture / Q000008:administration & dosage; D000771:Anesthesia, Intravenous; D001921:Brain / Q000601:surgery*; D002648:Child; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D009270:Naloxone / Q000494:pharmacology
D009270:Naloxone; D000530:Alfaxalone Alfadolone Mixture; D005283:Fentanyl