[Investigations on combined injuries, 25th communication: renal function and energy metabolism in mice with injuries combined of whole-body irradiation and an open skin wound (author's transl)].
In NMRI-mice injured with combined lesions (whole-body irradiation with 500 R and, two or seven days later, an open skin wound), lethality increased from 10 or 20% following sole irradiation up to 60%. Investigations of urinary excretion and serum levels in animals with combined injuries did not show undue elevations of the levels of electrolytes, creatinine, urea, uric acid and acid or alkaline equivalents. Analysis of lactate, pyruvate, ATP and ADP in liver tissue and blood serum indicated no significant changes in the energy metabolism in animals with combined injuries in comparison with mice irradiated only. These findings and those of our last communication (24. Mitteilung) seem to be incompatible with the presence of a shock state as cause of the high lethality of mice with combined injuries.
D000818:Animals; D004734:Energy Metabolism / Q000528:radiation effects*; D005260:Female; D005919:Glomerular Filtration Rate / Q000528:radiation effects; D007668:Kidney / Q000528:radiation effects*; D051379:Mice; D011833:Radiation Injuries, Experimental / Q000503:physiopathology; D012867:Skin / Q000293:injuries*
Untersuchungen über Kombinationsschäden. 25. Mitteilung: Uber die Nierenfunktion und den Energiehaushalt bei Mäusen, die durch Ganzkörperbestrahlung in Kombination mit offener Hautwunde belastet wurden.