Investigations into the mechanism of progesterone release by rat lutein cells.
Vinblastine treatment blocks progesterone release from the lutein cells of superovulated immature rat ovaries, without impairing hormone synthesis, and induces the accumulation of electron-dense granules, 0.2--0.3 micron in diameter, at the juxta-sinusoidal poles of the cells. The hypothesis is advanced that these granules are true secretory organelles and that an exocytotic mechanism underlies the progesterone release from rat lutein cells.
D000818:Animals; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D003338:Corpus Luteum / Q000378:metabolism*; D003594:Cytoplasmic Granules / Q000187:drug effects / Q000648:ultrastructure; D005089:Exocytosis; D005260:Female; D008184:Luteal Cells / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D011374:Progesterone / Q000097:blood / Q000378:metabolism*; D051381:Rats; D014747:Vinblastine / Q000494:pharmacology
D006063:Chorionic Gonadotropin; D011374:Progesterone; D014747:Vinblastine