Studies on the quantification of local tissue injury following intramuscular injection of aqueous solutions. VIII. The local lesion after application of turimycin in different preparations.
The increase in drug concentration in aqueous solutions is not responded to by a comparable enlargement of volume of necrosis after intramuscular injection. After application of TURIMYCIN the lesion is more voluminous than those caused by penicillin, lower than those following OTESOLUT and nearly equal to those caused by 5% WOFAPYRIN (phenylbutazone + aminophenazone 1:1).
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D007273:Injections, Intramuscular / Q000009:adverse effects*; D007933:Leucomycins / Q000008:administration & dosage*; D008297:Male; D009132:Muscles / Q000473:pathology*; D009336:Necrosis / Q000139:chemically induced; D051381:Rats; D012996:Solutions
D000900:Anti-Bacterial Agents; D007933:Leucomycins; D012996:Solutions