Oxidation of synephrine by type A and type B monoamine oxidase.
Synephrine (SP) was found to be a substrate for monoamine oxidase (MAO) in rat brain mitochondria, showing the Km and Vmax values of 250 microM and 32.6 nmoles/mg of protein/30 min respectively. The inhibition studies showed that the SP oxidation was carried out by both type A and type B MAO and a major part of the activity was due to type A MAO.
D000818:Animals; D001921:Brain / Q000201:enzymology*; D003010:Clorgyline / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D007700:Kinetics; D008297:Male; D008928:Mitochondria / Q000201:enzymology*; D008995:Monoamine Oxidase / Q000378:metabolism*; D051381:Rats; D012642:Selegiline / Q000494:pharmacology; D013578:Synephrine
D012642:Selegiline; D008995:Monoamine Oxidase; D003010:Clorgyline; D013578:Synephrine