The mouse anti-morphine constipation test--a simple laboratory test of the gastrointestinal side-effect potential of orally administered prostaglandin analogues.
A test is described which is simple, reliable and highly sensitive to the diarrhoea-inducing properties of orally administered prostaglandin analogues in mice. Comparison with human data shows similar orders of relative potency.
D015064:16,16-Dimethylprostaglandin E2; D000284:Administration, Oral; D000818:Animals; D005767:Gastrointestinal Diseases / Q000139:chemically induced*; D005769:Gastrointestinal Motility / Q000187:drug effects; D008297:Male; D009020:Morphine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D051381:Rats
D009020:Morphine; D015064:16,16-Dimethylprostaglandin E2