A review of the Zollinger-Ellison syndrome--with particular reference to a patient treated with cimetidine.
A case of the Zollinger-Ellison syndrome, presented with watery diarrhoea, malabsorption and multiple duodenal ulcers. Resection of a gastrinoma from the head of the pancreas was ineffective. Cimetidine, administered for more than 30 months produced an immediate and sustained relief of symptoms with a gain in weight of 19 kg and improvement of the biochemical features of malabsorption. Gastric acid secretion has been markedly inhibited and duodenal ulceration healed.
D000368:Aged; D002927:Cimetidine / Q000627:therapeutic use*; D006146:Guanidines / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D010183:Pancreatic Ducts / Q000000981:diagnostic imaging; D011859:Radiography; D015043:Zollinger-Ellison Syndrome / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000601:surgery
D006146:Guanidines; D002927:Cimetidine