The prognostic value of serum innumoglobulin levels in Hodgkin's disease.
Serum immunoglobulin concentrations have been measured in 31 patients with Hodgkin's lymphoma and related to disease activity and clinical stage. The patients with active untreated disease, the mean IgA concentration was significantly above the normal mean level and the mean IgM concentration was normal. No significant correlation was found between high IgA concentrations and liver involvement. There were decreased mean IgA and IgM concentrations during remission. The changes in immunoglobulin concentrations were found to be dependent on the clinical stage. The data suggest that in certain patients with active Hodgkin's lymphoma, the humoral-mediated immunity may be affected in addition to the cellular-mediated immunity.
D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D006689:Hodgkin Disease / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D011379:Prognosis
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins