title: Metabolites of 2-(3-trifluoromethylphenyl)tetrahydro-1,4-oxazine (CERM) 1841) in rats and dogs.
abstract: 1. In rats and dogs dosed with 14C-labelled 2-(3-trifluoromethylphenyl)tetrahydro-1,4-oxazine hydrochloride, the 14C was excreted in the urine. The 14C eliminated in the faeces of dog was significantly higher than for rat. 2. Conjugated metabolites, mostly glucuronides, accounted for the greater part of the urinary radioactivity in both species. 3. Biotransformation products were predominantly acids in both species, followed by significant amounts of basic metabolites, with very little neutral substances. 4. The major urinary metabolite in rats was 3-trifluoromethylbenzoic acid and 3-trifluoromethylhipuric acid. In the dog it was 3-trifluoromethylmandelic acid in addition to the benzoic acid and its conjugate. The basic products identified in the urine of both species were unchanged drug and 1-amino-2-hydroxy-2-(3-trifluoromethylphenyl)ethane, with the first predominating.
mesh_terms: D000284:Administration, Oral; D000700:Analgesics / Q000008:administration & dosage / Q000378:metabolism* / Q000652:urine; D000818:Animals; D001711:Biotransformation; D002855:Chromatography, Thin Layer; D004285:Dogs; D005243:Feces / Q000032:analysis; D007275:Injections, Intravenous; D008297:Male; D013058:Mass Spectrometry; D009025:Morpholines / Q000008:administration & dosage / Q000378:metabolism* / Q000652:urine; D051381:Rats; D013045:Species Specificity
chemical_list: D000700:Analgesics; D009025:Morpholines