Amniotic fluid phosphatidylinositol and phosphatidylglycerol. II. Diabetic and preeclamptic pregnancies.
139 samples of amniotic fluid from diabetic women collected during 34-39 weeks of pregnancy showed higher levels of lecithin, phosphatidylinositol (PI) and phosphatidylglycerol (PG) indicating an accelerated surfactant synthesis  as compared to that observed in normal pregnancies (13). In ten infants with respiratory distress syndrome (RDS) delivered from diabetic mothers the lecithin/sphingomyelin (L/S), PI/S and PG/S ratios were generally low. Only four samples showed definitely immature L/S ratios, whereas the amniotic fluid content of PG in all samples was unmeasurable or low. In 56 samples of amniotic fluid collected during the third trimester from preeclamptic pregnancies PI/S and PG/S ratios after 36-37 weeks were comparable with those of normal pregnancies. In 11 neonates with subsequent RDS the L/S ratios were immature, and PG was critically low or lacking in the majority of the samples. No convincing association between the PI content and development of RDS could be observed in any of the groups.
D000653:Amniotic Fluid / Q000032:analysis*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008055:Lipids / Q000032:analysis; D010713:Phosphatidylcholines / Q000032:analysis; D010715:Phosphatidylglycerols / Q000032:analysis*; D010716:Phosphatidylinositols / Q000032:analysis*; D010743:Phospholipids / Q000032:analysis; D010758:Phosphorus / Q000032:analysis; D011225:Pre-Eclampsia / Q000378:metabolism*; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000378:metabolism*; D012127:Respiratory Distress Syndrome, Newborn / Q000209:etiology; D013109:Sphingomyelins / Q000032:analysis
D008055:Lipids; D010713:Phosphatidylcholines; D010715:Phosphatidylglycerols; D010716:Phosphatidylinositols; D010743:Phospholipids; D013109:Sphingomyelins; D010758:Phosphorus