The metabolism of isamoxole in the rat and guinea-pig.
1. The absorption, metabolism and excretion of isamoxole, (2-methyl-N-butyl-N-(4-methyloxazol-2-yl)propanamide), a compound with anti-allergy properties, has been studied in the rat and guinea-pig. 2. The compound was well-absorbed by both species after oral doses of 50 to 150 mg/kg. It underwent extensive first-pass metabolism in the liver, and was excreted as a mixture of metabolites, predominantly in the urine, within 48 h. 3. Three major routes of metabolism were involved, namely deacylation, oxidative ring scission and alkyl oxidation. 4. A major plasma and urine metabolite was 1-butyl-3-(1-carboxyethyl)urea, and this was accompanied by low levels of its cyclized product 3-butyl-5-methylhydantoin.
D000818:Animals; D001711:Biotransformation; D006168:Guinea Pigs; D006967:Hypersensitivity / Q000188:drug therapy; D007408:Intestinal Absorption; D008168:Lung / Q000378:metabolism; D008297:Male; D010080:Oxazoles / Q000097:blood / Q000378:metabolism* / Q000652:urine; D051381:Rats; D013045:Species Specificity
D010080:Oxazoles; C017436:isamoxole