Moderate and extreme haemodilution in open-heart surgery: evaluation of haemolysis, cell damage and protein changes.
Clinical chemical data from patients operated upon in moderate and extreme haemodilution have been compared. Haemolysis was more pronounced during and after moderate dilution that in extreme dilution. A slight liver damage was found post-operatively after moderate dilution. Several changes were of about the same magnitude in both groups: Serum CK increased, reaching maximal activity 3-18 h after operation. An acute phase reaction of plasma proteins took place post-operatively, except that the concentration of complement C-3 dropped during the first days after operation. The serum levels of phosphate were positively correlated to several of the acute phase proteins.
D000410:Alanine Transaminase / Q000097:blood; D001663:Bilirubin / Q000097:blood; D001798:Blood Proteins / Q000032:analysis*; D006348:Cardiac Surgical Procedures; D003402:Creatine Kinase / Q000097:blood; D006438:Hemodilution / Q000009:adverse effects / Q000379:methods*; D006454:Hemoglobins / Q000032:analysis; D006461:Hemolysis; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008099:Liver / Q000473:pathology*; D013997:Time Factors
D001798:Blood Proteins; D006454:Hemoglobins; D007770:L-Lactate Dehydrogenase; D000410:Alanine Transaminase; D003402:Creatine Kinase; D001663:Bilirubin