Lung carcinoma induction in BD rats after a single intratracheal instillation of an arsenic-containing pesticide mixture formerly used in vineyards.
A single intratracheal 0.1-ml instillation of a calcium-arsenate containing vineyard pesticide induced multi-focal bronchogenic adenocarcinomas and bronchiolar-alveolar-cell carcinomas in nine out of 15 treated BD rats. This seems to be the first experimental confirmation of carcinogenicity of arsenic-containing pesticides used formerly in vineyards.
D000230:Adenocarcinoma / Q000139:chemically induced; D000818:Animals; D001149:Arsenates / Q000009:adverse effects*; D001151:Arsenic / Q000009:adverse effects*; D002283:Carcinoma, Bronchogenic / Q000139:chemically induced*; D005638:Fruit; D007267:Injections; D008168:Lung / Q000187:drug effects / Q000473:pathology; D008175:Lung Neoplasms / Q000139:chemically induced*; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced; D010575:Pesticides / Q000009:adverse effects*; D051381:Rats; D014132:Trachea
D001149:Arsenates; D010575:Pesticides; D001151:Arsenic