title: Effect of immunochemotherapy with OK-432 and yeast cell wall on the activities of peritoneal macrophages of mice.
abstract: The effect of chemotherapy combined with immunostimulants on the activities of macrophages in mice was studied. The number of macrophages and exudate cells in the peritoneal cavity increased 3 days after ip injection with mitomycin-C, cyclophosphamide, and 5-fluorouracil together with OK-432 or yeast cell wall and decreased to normal level after 9 days, while the number of the cells remained decreased in mice receiving multi-drugs alone. Acid phosphatase activity of the macrophages of mice was elevated after the simultaneous injection of yeast cell wall and OK-432, and high activity was preserved in the macrophages of mice receiving yeast cell wall even after 9 days. Spreading of these cells was also enhanced. Macrophage activities examined by these assays were maximal in every respect 6 days after combination therapy. Cytostatic activity of the cells was strengthened after 6 days by combined use of OK-432 or yeast cell wall. Role of the activated macrophages in combination therapy was discussed.
mesh_terms: D000135:Acid Phosphatase / Q000032:analysis; D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology; D001688:Biological Products / Q000627:therapeutic use*; D002286:Carcinoma, Ehrlich Tumor / Q000628:therapy*; D002473:Cell Wall / Q000276:immunology; D005260:Female; D007167:Immunotherapy / Q000379:methods; D008264:Macrophages / Q000187:drug effects / Q000201:enzymology / Q000276:immunology*; D008297:Male; D051379:Mice; D008937:Mitomycins / Q000627:therapeutic use; D010844:Picibanil / Q000627:therapeutic use*; D015003:Yeasts / Q000276:immunology*
chemical_list: D001688:Biological Products; D008937:Mitomycins; D010844:Picibanil; D000135:Acid Phosphatase