Change in myocardial metabolism in man by a new stimulator of carbohydrate oxidation.
The effect on human myocardial metabolism of (S)-4-hydroxyphenylglycine, a substance which in animal experiments has been shown to stimulate carbohydrate metabolism mainly by activation of pyruvate dehydrogenase was studied in five healthy volunteers by coronary sinus catheterization. 90 min after i.v. injection of the drug myocardial extraction of glucose and lactate was doubled, myocardial oxidation of plasma free fatty acids (FFA) significantly reduced and myocardial RQ increased accordingly. This a pronounce shift towards carbohydrate oxidation was achieved with a dose which gave no side effects.
D000328:Adult; D050260:Carbohydrate Metabolism; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005998:Glycine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D010084:Oxidation-Reduction; D010101:Oxygen Consumption / Q000187:drug effects
D005230:Fatty Acids, Nonesterified; C023010:4-hydroxyphenylglycine; D005998:Glycine