Response of Pseudomonas cepacia to beta-Lactam antibiotics: utilization of penicillin G as the carbon source.
Pseudomonas cepacia utilized penicillin G as the sole source of carbon and energy. We report here an unexplained correlation between lysine auxotrophy and beta-lactamase deficiency, resulting in loss of capacity to utilize penicillin.
D002511:Cephalosporins / Q000494:pharmacology; D008239:Lysine / Q000378:metabolism; D009154:Mutation; D010400:Penicillin G / Q000378:metabolism*; D010403:Penicillin Resistance; D010406:Penicillins / Q000494:pharmacology; D011549:Pseudomonas / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D013045:Species Specificity; D047090:beta-Lactams / Q000378:metabolism*
D002511:Cephalosporins; D010406:Penicillins; D047090:beta-Lactams; D008239:Lysine; D010400:Penicillin G