Cell turnover of the gastric mucosa is reduced by clanobutin.
4-(4-chlor-N-(4-methoxyphenyl)-benzamido)-butanic acid (clanobutin) reduces gastric cell exfoliation at an oral dose of 1800 mg/day. A dose of 900 mg/day had no effect. It may thus exert its benefical effect on ulcer healing.
D000328:Adult; D002470:Cell Survival / Q000187:drug effects; D004247:DNA / Q000032:analysis; D005260:Female; D005753:Gastric Mucosa / Q000166:cytology / Q000187:drug effects*; D006801:Humans; D008297:Male; D013276:Stomach Ulcer / Q000188:drug therapy; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use
D005680:gamma-Aminobutyric Acid; D004247:DNA; C019159:clanobutin