Inducibility of microsomal enzymes in normal and pre-cancerous lung tissue. Synergistic action of 5-6 benzoflavon or methyl-cholanthrene in radiation induced carcinogenesis.
The inducibility of pulmonary microsomal enzymes and the biological effects of chronic induction by 5-6 benzoflavone and methylcholanthrene were compared in normal and precancerous rats. Two important points were shown out: a dose of 6000 WLM resulted in a permanent modification of the pulmonary microsomal enzymatic pool and 5-6 benzoflavon was a strong co-factor of radiation induced carcinogenesis. This synergistic action was demonstrated by a much shorter latency, moreover neo-formed tissue and epidermoid cancers with a particular morphology were observed. In all the cases cancers appeared within 100 days following the beginning of the chemical treatment.
D000818:Animals; D001571:Benzoflavones / Q000494:pharmacology; D002294:Carcinoma, Squamous Cell / Q000201:enzymology / Q000209:etiology; D004790:Enzyme Induction / Q000187:drug effects*; D008168:Lung / Q000201:enzymology*; D008175:Lung Neoplasms / Q000201:enzymology* / Q000209:etiology; D008297:Male; D008748:Methylcholanthrene / Q000494:pharmacology; D008861:Microsomes / Q000201:enzymology*; D009374:Neoplasms, Experimental / Q000201:enzymology; D009381:Neoplasms, Radiation-Induced / Q000201:enzymology*; D011230:Precancerous Conditions / Q000201:enzymology*; D011886:Radon; D051381:Rats
D001571:Benzoflavones; D008748:Methylcholanthrene; D011886:Radon