Evidence of high polymeric IgA levels in serum of patients with Berger's disease and its modification with phenytoin treatment.
High levels of polymeric IgA were found in the serum of patients with IgA glomerulonephritis. In four of the patients the IgA percentage distribution was established by ultracentrifugation in sucrose density gradients before and after six months of phenytoin treatment. A decrease in polymeric IgA, adopting a pattern similar to the controls, was observed. These findings may have both pathogenic and therapeutic implications.
D002499:Centrifugation, Density Gradient; D005921:Glomerulonephritis / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A; D008970:Molecular Weight; D010672:Phenytoin / Q000627:therapeutic use*; D011108:Polymers; D013997:Time Factors
D007070:Immunoglobulin A; D011108:Polymers; D010672:Phenytoin