A potent inhibitor of cell proliferation in "middle molecules" isolated from the urine of uremic patients.
A potent inhibitor of cell proliferation was found in the urine of a patient with chronic renal failure. This substance included in "middle molecules" (MM) fraction, was obtained by chromatography. This factor was shown to inhibit noticeably the proliferation of various cells : lymphocytes stimulated by allogeneic cells, monolayer cell lines of normal or tumorous origin and leukemic cell lines derived from acute lymphoblastic leukemia. This effect was reversible and thus could not be related to a direct, rapid cytotoxic effect of MM. Such substances could play an important part in uremic symptoms, such as immunodeficiency, anemia, thrombopenia, gastrointestinal or skin manifestations.
D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D004622:Embryo, Mammalian; D006801:Humans; D007676:Kidney Failure, Chronic / Q000503:physiopathology*; D051379:Mice; D014020:Tissue Extracts / Q000494:pharmacology*; D014118:Toxins, Biological / Q000652:urine*; D014511:Uremia / Q000652:urine*
D014020:Tissue Extracts; D014118:Toxins, Biological