[Hypopituitarism and hyperlipidemia. Protective effect of growth hormone deficiency against atherosclerosis (author's transl)].
A serie of 12 cases of hypopituitarism (Sheehan's syndrome, pituitary adenoma, idiopathic) associated with hyperlipidemia (type IIb in general), is reported. It is suggested that: 1--Growth hormone deficiency seems to have a protective effect against atherosclerosis in hyperlipidemia because there are no cardiovascular signs in 10 cases with a history of growth hormone deficiency lasting from 5 to 57 years and a manifesting hyperlipidemia (lasting a mean of 23 years), and there is stabilisation or improvement of ischemic signs in 2 other cases. 2--Lipid abnormalities are frequently seen in hypopituitarism even after thyroid replacement therapy. 3--The hyperlipidemia can be familial or can result from growth hormone deficiency alone.
D000328:Adult; D000368:Aged; D001161:Arteriosclerosis / Q000517:prevention & control*; D005260:Female; D013006:Growth Hormone / Q000172:deficiency*; D006801:Humans; D006949:Hyperlipidemias / Q000503:physiopathology*; D007018:Hypopituitarism / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged
D013006:Growth Hormone
Hypopituitarisme et hyperlipidémie. Effet préventif du déficit somatotrope sur le développement de l'athérosclérose. A propos de 12 observations.