Node-like areas of intramembraneous particles in the unensheathed axons of dystrophic mice.
The unensheathed axons in the spinal roots of adult dystrophic mice were examined by freeze-fracture electron microscopy. In most areas of these abnormal fibers the distribution of intramembraneous particles was similar to that of the internodal segments of normal axons with many more particles on the PF (internal) leaflets of these axonal surface membranes than on their EF (external) leaflets. However, patches of axonal membranes were also observed in which the distribution of intramembraneous particles resembled that seen in nodes of Ranvier.
D000818:Animals; D001369:Axons / Q000648:ultrastructure*; D005614:Freeze Fracturing; D051379:Mice; D008815:Mice, Inbred Strains; D008854:Microscopy, Electron; D009137:Muscular Dystrophy, Animal / Q000473:pathology* / Q000503:physiopathology; D009431:Neural Conduction; D013126:Spinal Nerve Roots / Q000473:pathology* / Q000503:physiopathology