Effect of dipyridamole on the survival of experimental critical skin flaps.
The effect of dipyridamole (Persantin) on the survival of experimental skin flaps was studied. In controls 39% of the skin flap area survived. Intraperitoneal injection of dipyridamole 4 mg/kg twice daily starting four hours preoperatively increased the surviving area with 18%. This increase is statistically significant (p less than 0.05). The improved survival could be due to the vasodilatory action of the drug and/or proliferation of small bloodvessels induced by the drug.
D000818:Animals; D004176:Dipyridamole / Q000494:pharmacology*; D006085:Graft Survival / Q000187:drug effects*; D008297:Male; D051381:Rats; D013524:Surgical Flaps
D004176:Dipyridamole