Induction of haemorrhagic necrosis in a murine tumour by products from the culture fluid of Azotobacter.
Macromolecules in the supernatant from cultures of the nitrogen-fixing bacterium Azotobacter chroococcum when given systemically induce permanent regression of established grafts of a syngeneic murine lymphoma. The effect mimics that produced by endotoxin in that haemorrhagic necrosis is induced in the tumour, but the ratio of the toxic dose to the dose needed to cause tumour regression is greater than for this culture supernatant than for endotoxin.
D000818:Animals; D001395:Azotobacter; D001427:Bacterial Toxins / Q000627:therapeutic use*; D003470:Culture Media / Q000032:analysis; D006470:Hemorrhage; D007940:Leukemia L5178 / Q000628:therapy*; D007942:Leukemia, Experimental / Q000628:therapy*; D051379:Mice; D008811:Mice, Inbred DBA; D009336:Necrosis
D001427:Bacterial Toxins; D003470:Culture Media