Effect of oily vehicle on ocular pilocarpine concentration.
The effect of 1.4% polyvinyl alcohol (PVA) vehicle and of castor oil vehicle on ocular pilocarpine concentration was studied by radioactive method in the rabbit eye. Statistically higher radioactivities were measured from the anterior surface structures of the eyes dropped with oily vehicle when compared to PVA vehicle at 120 min. It is concluded that the conjunctiva and the cornea serve as a drug reservoir for the longlasting drug effect observed in the literature after oily pilocarpine drops.
D000818:Animals; D002368:Castor Oil / Q000494:pharmacology*; D003228:Conjunctiva / Q000378:metabolism; D003315:Cornea / Q000378:metabolism; D005123:Eye / Q000378:metabolism*; D009883:Ophthalmic Solutions; D014677:Pharmaceutical Vehicles; D010862:Pilocarpine / Q000008:administration & dosage* / Q000378:metabolism; D011142:Polyvinyl Alcohol / Q000494:pharmacology*; D011817:Rabbits
D009883:Ophthalmic Solutions; D014677:Pharmaceutical Vehicles; D010862:Pilocarpine; D002368:Castor Oil; D011142:Polyvinyl Alcohol