Synergistic effect of alcohol on epidermoid carcinogenesis in the larynx.
Forty hamsters received weekly installations of benzopyrene into the larynx. Twenty of these also had 10% alcohol as their total liquid intake. Carcinoma of the larynx was seen in seven alcoholic vs two nonalcoholic hamsters, supporting the evidence in humans that alcohol is a factor in epidermoid carcinogenesis of the larynx.
D000818:Animals; D001580:Benzopyrenes / Q000494:pharmacology*; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced* / Q000473:pathology; D006224:Cricetinae; D004357:Drug Synergism; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D007822:Laryngeal Neoplasms / Q000139:chemically induced* / Q000473:pathology; D008954:Models, Biological
D001580:Benzopyrenes; D000431:Ethanol