In vitro actions of some antibiotics on phospholipases.
The effects of some antibiotics on activities of phospholipase A2, B and C were investigated in vitro. Tetracyclines, macrolides, chloramphenicol and carbenicillin inhibited the activity of Crotalus adamanteus phospholipase A2 towards phospholipids of egg-yolk emulsions. When the ability to inhibit the activity of Penicillium notatum phospholipase B towards mixed micelles of phosphatidylcholine and Triton X-100 was investigated, polymyxin B was found to be inhibitory while chloramphenicol and carbenicillin were found to stimulate the activity of the phospholipase. The activity of Bacillus cereus phospholipase C towards the mixed micelles was inhibited by bleomycin, oleandomycin and chloramphenicol.
D002228:Carbenicillin / Q000494:pharmacology*; D002701:Chloramphenicol / Q000494:pharmacology*; D003864:Depression, Chemical; D008245:Lysophospholipase / Q000378:metabolism; D010740:Phospholipases / Q000378:metabolism*; D010741:Phospholipases A / Q000378:metabolism; D054467:Phospholipases A2; D013754:Tetracyclines / Q000494:pharmacology*; D010738:Type C Phospholipases / Q000378:metabolism
D013754:Tetracyclines; D002701:Chloramphenicol; D010740:Phospholipases; D010741:Phospholipases A; D054467:Phospholipases A2; D008245:Lysophospholipase; D010738:Type C Phospholipases; D002228:Carbenicillin