Clomiphene-induced pregnancy in a patient with diabetes insipidus and hypothyroidism.
A patient with diabetes insipidus and hypothyroidism developed anovular menstrual cycles. Ovulation, which was followed by pregnancy, was induced by the administration of clomiphene. In the later stages of pregnancy, an increase in the dosage of vasopressin was necessary to achieve a satisfactory control of the symptoms of diabetes insipidus. Labour was induced before the estimated date of confinement by the intravenous administration of oxytocin and an intra-partum haemorrhage necessitated delivery by the lower-segment caesarean section. The post-partum period was uneventful. Lactation was suppressed on request from the patient.
D000328:Adult; D000858:Anovulation / Q000188:drug therapy; D002996:Clomiphene / Q000627:therapeutic use*; D003919:Diabetes Insipidus / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000503:physiopathology*; D007247:Infertility, Female / Q000188:drug therapy*; D007751:Labor, Induced; D010060:Ovulation / Q000187:drug effects*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology; D011254:Pregnancy in Diabetics / Q000503:physiopathology*; D014667:Vasopressins / Q000008:administration & dosage
D014667:Vasopressins; D002996:Clomiphene