Production of hydroxyl radical by human alveolar macrophages.
Stimulated human alveolar macrophages were demonstrated to oxidize B-methyl proprionaldehyde (methional) or 2-keto-4-thiomethylbutyric acid to ethylene (C2H4). Agents which are believed to scavenge the hydroxyl radical (.OH), sodium benzoate, and mannitol, as well as scavengers of superoxide anion (O2-) or hydrogen peroxide, decreased C2H4 production, implicaing .OH as the oxidizing radical. Differences in C2H4 rpoduction, as well as oxygen uptake and O2- release between human alveolar macrophages and polymorphonuclear leukocytes, were also documented.
D000447:Aldehydes / Q000378:metabolism; D002087:Butyrates / Q000378:metabolism; D002374:Catalase / Q000494:pharmacology; D005030:Ethylenes / Q000378:metabolism*; D005609:Free Radicals / Q000378:metabolism*; D006801:Humans; D006878:Hydroxides / Q000378:metabolism*; D007651:Keto Acids / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism*; D009504:Neutrophils / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism; D010101:Oxygen Consumption; D011650:Pulmonary Alveoli / Q000166:cytology*; D013438:Sulfhydryl Compounds / Q000378:metabolism; D013482:Superoxide Dismutase / Q000494:pharmacology; D015054:Zymosan / Q000494:pharmacology
D000447:Aldehydes; D002087:Butyrates; D005030:Ethylenes; D005609:Free Radicals; D006878:Hydroxides; D007651:Keto Acids; D013438:Sulfhydryl Compounds; C008390:methional; D015054:Zymosan; D002374:Catalase; D013482:Superoxide Dismutase; D010100:Oxygen