title: Studies on bacterial cell wall inhibitors. VII. Azureomycins A and B, new antibiotics produced by Pseudonocardia azurea nov. sp. Taxonomy of the producing organism, isolation, characterization and biological properties.
abstract: Two new basic water-soluble antibiotics, azureomycins A and B, were isolated from the culture broth of an actinomycete, strain AM-3696, designated as Pseudonocardia azurea nov. sp. The antibiotics exhibit moderate antimicrobial activities against Gram-positive bacteria including penicillin-resistant Staphylococcus, Mycobacterium and Clostridium. They inhibit the synthesis of bacterial cell wall peptidoglycan.
mesh_terms: D000192:Actinomycetales / Q000145:classification / Q000378:metabolism* / Q000648:ultrastructure; D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D005285:Fermentation; D051379:Mice; D010452:Peptide Biosynthesis; D010455:Peptides / Q000302:isolation & purification / Q000494:pharmacology; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D010455:Peptides