title: Effect of low dose secretin and caerulein on pure pancreatic bicarbonate secretion and plasma secretin in man.
abstract: In six healthy volunteers pure pancreatic juice was obtained by endoscopic cannulation of the main pancreatic duct. Following a 20-min basal period, secretin (0.03 CU/kg, h) was intravenously infused alone for 20 min and then with caerulein 15 ng/kg, h for further 20 min. From a basal level of 28 +/- 13 mu mol/5 min, secretin by itself significantly increased pancreatic bicarbonate to 182 +/- 24 mu mol/5 min. A further significant two-fold increase to 396 +/- 50 mu mol/5 min was observed during caerulein. The increment in plasma secretin of 2.1 +/- 0.3 pmol/l is comparable to the rise that may be observed post-prandially. It is concluded that secretin in combination with cholecystokinin may indeed play a physiological role in the regulation of duodenal pH.
mesh_terms: D000328:Adult; D001639:Bicarbonates / Q000378:metabolism*; D002108:Ceruletide / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D010189:Pancreatic Juice / Q000032:analysis; D012633:Secretin / Q000097:blood / Q000494:pharmacology*
chemical_list: D001639:Bicarbonates; D012633:Secretin; D002108:Ceruletide