title: Fowl cholera: cross-protection induced by Pasteurella multocida separated from infected turkey blood.
abstract: Crude liver homogenates from turkeys that died of fowl cholera produced by serotype 1 or 3 Pasteurella multocida induced cross-protection. Pasteurella multocida harvested from the blood of infected turkeys by a centrifugal technique were as immunogenic as the liver homogenates. Neither bacterial cell-free blood plasma nor washed P. multocida from infected turkeys induced significant cross-protection. Blood plasma containing P. multocida induced significant cross-protection. Pasteurella multocida grown in the turkey underwent bacteriolysis after thawing from a frozen state. Filtered lysates did not induce cross-protection when used as vaccines whereas unfiltered lysates did. Membrane filters impeded passage of immunogenic material.
mesh_terms: D000818:Animals; D001428:Bacterial Vaccines / Q000302:isolation & purification; D001769:Blood / Q000382:microbiology*; D002474:Cell-Free System; D003429:Cross Reactions; D005260:Female; D008099:Liver / Q000382:microbiology; D008297:Male; D010325:Pasteurella / Q000276:immunology* / Q000302:isolation & purification; D010326:Pasteurella Infections / Q000382:microbiology / Q000517:prevention & control / Q000662:veterinary*; D011201:Poultry Diseases / Q000382:microbiology / Q000517:prevention & control*; D014422:Turkeys
chemical_list: D001428:Bacterial Vaccines