title: Involvement of the cholinergic mechanism in depression of the caudate spindle.
abstract: Involvement of the cholinergic and catecholaminergic mechanisms in the caudate spindle recorded from the anterior and posterior sigmoid gyri was examined in cats. Physostigmine (0.01 to 0.1 mg/kg i.v.) abolished the appearance of the caudate spindle. These inhibitory effects were antagonized by the administration of atropine (0.25 to 1 mg/kg i.v.). The caudate spindle was inhibited by high frequency stimulation of the mesencephalic reticular formation: This inhibitory effect was antagonized by atropine. On the other hand, L-DOPA (25 to 50 mg/kg, i.v.), L-DOPA + MAO inhibitor and methamphetamine (0.5 to 5 mg/kg i.v.) did not influence the caudate spindle. These results suggest an involvement of cholinergic mechanism in depression of the caudate spindle.
mesh_terms: D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D002415:Cats; D002421:Caudate Nucleus / Q000187:drug effects / Q000502:physiology*; D003864:Depression, Chemical; D005260:Female; D007980:Levodopa / Q000494:pharmacology; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D010830:Physostigmine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D012154:Reticular Formation / Q000502:physiology
chemical_list: D008996:Monoamine Oxidase Inhibitors; D008694:Methamphetamine; D007980:Levodopa; D001285:Atropine; D010830:Physostigmine