title: Chromosome 1 abnormalities in relapse and terminal stages in childhood leukemia.
abstract: Seven of 114 children with leukemia were shown to have abnormalities of chromosome 1. These included trisomy of parts of chromosome 1 as well as translocations of chromosome 1 to other chromosomes. The abnormalities were found during a relapse or terminal stage, after which the patient was refractory to therapy in all cases.
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D002900:Chromosomes, Human, 1-3; D005260:Female; D006801:Humans; D007938:Leukemia / Q000235:genetics*; D008297:Male; D009367:Neoplasm Staging; D011379:Prognosis; D014178:Translocation, Genetic; D014314:Trisomy