title: Simple epoxide analogs of trichothecans.
abstract: To define clearly the epoxide grouping role in trichothecan biological activity, a series of hindered epoxides was prepared. They possessed alpha, alpha'-substitution reminiscent of the epoxide environment of the natural products. None of these analogs demonstrated biological activities similar to the natural toxins.
mesh_terms: D055598:Chemical Phenomena; D002621:Chemistry; D008826:Microbial Sensitivity Tests; D009161:Mycobacterium / Q000187:drug effects; D012717:Sesquiterpenes / Q000138:chemical synthesis*; D014255:Trichothecenes / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D012717:Sesquiterpenes; D014255:Trichothecenes