title: Comparison of labetalol, clonidine and diazoxide intravenously administered in severe hypertension.
abstract: Diazoxide, clonidine and labetalol, administered intravenously in fixed doses, were used to treat 30 episodes of severe hypertension in 27 patients. Labetalol in a fixed dose of 100 mg proved ineffective treatment. Diazoxide 300 mg and clonidine 300 micrograms were comparable in effectiveness. Drowsiness was a common side effect with administration of clonidine (in six of 10 patients) and severe hypotension occurred in one patient who was given diazoxide.
mesh_terms: D000328:Adult; D003000:Clonidine / Q000008:administration & dosage / Q000627:therapeutic use*; D003981:Diazoxide / Q000008:administration & dosage / Q000627:therapeutic use*; D004983:Ethanolamines / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007275:Injections, Intravenous; D007741:Labetalol / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male
chemical_list: D004983:Ethanolamines; D003000:Clonidine; D003981:Diazoxide; D007741:Labetalol