Enhancement of dopamine-induced stimulation of pancreatic secretion by 5-dimethyldithiocarbamylpicolinic acid (YP-279), a dopamine beta-hydroxylase inhibitor.
Effect of 5-dimethyldithiocarbamylpicolinic acid (YP-279), a dopamine beta-hydroxylase inhibitor, on the secretion of pancreatic juice induced by dopamine was investigated in preparations of the isolated blood-perfused canine pancreas. Either a single injection (300 micrograms) or an infusion (100 micrograms/min) of YP-279 intra-arterially (i.a.) caused no change in the outflow of the pancreatic juice, but the secretagogue effect of dopamine (1-10 micrograms, i.a.) was enhanced by the infusion of YP-279 (100 micrograms/min, i.a.) for 60 min. The previous conclusion obtained with fusaric acid was confirmed as follows; the dopamine beta-hydroxylase activity controls the dopaminergic mechanism of the pancreatic secretion.
D000818:Animals; D004285:Dogs; D004298:Dopamine / Q000494:pharmacology*; D004299:Dopamine beta-Hydroxylase / Q000037:antagonists & inhibitors*; D004357:Drug Synergism; D005260:Female; D008297:Male; D010179:Pancreas / Q000378:metabolism*; D010848:Picolinic Acids / Q000494:pharmacology*; D013268:Stimulation, Chemical
D010848:Picolinic Acids; C006080:5-dimethyldithiocarbamylpicolinic acid; D004299:Dopamine beta-Hydroxylase; D004298:Dopamine