title: Mixed connective tissue disease. Appearance of antibodies to ribonucleoprotein following corticosteroid treatment.
abstract: Antibodies to ribonucleoprotein are the serological marker of mixed connective tissue disease (MCTD). Five patients are presented who had negative or low titer anti-RNP antibodies despite characteristic MCTD. In all 5 patients antibodies to RNP appeared after they had taken prednisone for periods ranging from 3 wk to 15 months.
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000906:Antibodies / Q000032:analysis*; D005260:Female; D006801:Humans; D008875:Middle Aged; D008947:Mixed Connective Tissue Disease / Q000097:blood / Q000188:drug therapy / Q000276:immunology*; D012261:Ribonucleoproteins / Q000276:immunology
chemical_list: D000305:Adrenal Cortex Hormones; D000906:Antibodies; D012261:Ribonucleoproteins