Uptake and efflux of noradrenaline from platelets; a model system for neurogenic mechanisms in essential hypertension.
1. The rate (k) of initial efflux of noradrenaline from platelets was determined in 63 individuals. A highly significant correlation was found between diastolic blood pressure and efflux rate. 2. When platelets are incubated in buffers with various Na+ concentrations in the range 110-170 mmol/l a higher Na+ concentration will give a faster efflux of noradrenaline for each concentration tested. 3. The value for k was determined in 41 normotensive first-degree relatives of hypertensive individuals and 21 persons with no family history of hypertension. Efflux rate of noradrenaline was significantly higher in the relatives and within this group was a subgroup with very high k values.
D000328:Adult; D000368:Aged; D001692:Biological Transport / Q000187:drug effects; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D001794:Blood Pressure; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000235:genetics / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D009474:Neurons / Q000502:physiology*; D009638:Norepinephrine / Q000097:blood*; D012964:Sodium / Q000494:pharmacology
D012964:Sodium; D009638:Norepinephrine