title: Time courses and refractoriness of enhanced vascular permeability induced by histamine, serotonin and bradykinin in synovialis of the rat.
abstract: Enhanced vascular permeability induced in synovialis of the rat by histamine and serotonin lasts 5-15 min and that induced by bradykinin less than 5 min. Synovialis of the rat becomes refractory to the permeability effects of repeated doses of each of these substances in the hour following initial application.
mesh_terms: D000818:Animals; D001920:Bradykinin / Q000494:pharmacology*; D002199:Capillary Permeability / Q000187:drug effects*; D005260:Female; D006632:Histamine / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D051381:Rats; D012701:Serotonin / Q000494:pharmacology*; D013582:Synovial Fluid / Q000187:drug effects / Q000502:physiology*
chemical_list: D012701:Serotonin; D006632:Histamine; D001920:Bradykinin