Absorption and metabolism of naphthalene and benzo(a)pyrene in the rat jejunum in situ.
Naphthalene or benzo(a)pyrene (100 nmol) was instilled into the closed rat intestinal loop in situ and the appearance of the free compound and its metabolites was determined in portal blood. Naphthalene appeared mostly unchanged in blood whereas benzo(a)pyrene was extensively metabolized by mucosal cells. The results suggest that absorption and metabolism are competing processes in the gut.
D000818:Animals; D001580:Benzopyrenes / Q000097:blood / Q000378:metabolism*; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000378:metabolism; D007583:Jejunum / Q000378:metabolism*; D008297:Male; D009281:Naphthalenes / Q000097:blood / Q000378:metabolism*; D009284:Naphthols / Q000097:blood / Q000378:metabolism; D051381:Rats
D001580:Benzopyrenes; D009281:Naphthalenes; D009284:Naphthols