Gallbladder contraction as a test for vagal innervation.
A subthreshold dose of carbachol was used to test gallbladder reaction in a series of patients before operation, after truncal vagotomy with antrectomy (TA) and after parietal cell vagotomy (PCV) because of duodenal ulcer. A small but statistically significant size reduction was seen before operation, a much higher reduction after TA and after PCV, that after TA being significantly higher than after PCV. It must be assumed that after PCV a number of gallbladders is in a state of denervation.
D002217:Carbachol / Q000494:pharmacology*; D002765:Cholecystography; D002766:Cholecystokinin / Q000494:pharmacology*; D004381:Duodenal Ulcer / Q000601:surgery; D005704:Gallbladder / Q000187:drug effects* / Q000294:innervation / Q000502:physiology; D006801:Humans; D011706:Pyloric Antrum / Q000601:surgery; D014628:Vagotomy; D014630:Vagus Nerve / Q000502:physiology*
D002217:Carbachol; D002766:Cholecystokinin