A model of left ventricular function in the denervated heart.
A model has been formulated for the function of the denervated left ventricle. Using the model it is possible to generate realistic waveforms for aortic flow, aortic pressure, left ventricular volume and left ventricular pressure over a wide range of simulated haemodynamic conditions. The effect of changes in contractile state is introduced through the concept of left ventricular pumping capacity. Model results compare well with similar data obtained from denervated hearts in open-chest dogs anaesthetized with halothane under positive pressure ventilation. Simulation of changes in contractile state shows excellent agreement with data published by previous investigators.
D000818:Animals; D001011:Aorta / Q000502:physiology; D001794:Blood Pressure; D002302:Cardiac Output; D002306:Cardiac Volume; D003714:Denervation; D004285:Dogs; D006321:Heart / Q000502:physiology; D006327:Heart Block / Q000503:physiopathology; D006329:Heart Conduction System / Q000502:physiology; D006339:Heart Rate; D008955:Models, Cardiovascular; D009200:Myocardial Contraction; D013318:Stroke Volume; D016276:Ventricular Function