Function of macrophage prostaglandins in the process of phagocytosis.
The role of prostaglandins (PGs) in phagocytosis of sheep erythrocytes (SRC) by mouse spleen adherent cells was examined. A decrease of about 50% in the phagocytosis was observed when macrophages were treated with 5 microgram/ml indomethacin. Concomitant addition of PGs (10(-6) mg/ml), however, prevented the inhibitory effect of indomethacin. It is thus suggested that PGs play an important role in phagocytosis.
D000818:Animals; D001095:Arachidonic Acids / Q000494:pharmacology; D002448:Cell Adhesion; D004912:Erythrocytes / Q000276:immunology; D007213:Indomethacin / Q000494:pharmacology; D008264:Macrophages / Q000502:physiology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009829:Oleic Acids / Q000494:pharmacology; D009895:Opsonin Proteins; D010587:Phagocytosis; D011453:Prostaglandins / Q000502:physiology*; D012756:Sheep
D001095:Arachidonic Acids; D009829:Oleic Acids; D009895:Opsonin Proteins; D011453:Prostaglandins; D007213:Indomethacin