Antiinflammatory substances appearing during an acute inflammation and the alteration of their properties by isoproterenol (ISO). An in vivo investigation in rats.
It could be demonstrated that antiinflammatory substances appear during the course of an acute inflammation. The inhibition of leucocyte immigration into the site of inflammation (caused by Sephadex) was taken as criterion for the antiinflammatory property. The highest quantity or effect of the antiinflammatory substances was found on the 3rd day after inflammation has started. Not only the absolute number of cells but also the composition of the cellular exudate (compared with a fresh inflammation) was changed: The percentage rate of the neutrophils was reduced, whereas the portion of the eosinophils and the lymphocytes was increased. A permanent ISO application on the animals altered the quantity of the composition of these substances, in consequence of which the immigration of eosinophils and lymphocytes was promoted. The reaction of the neutrophils was unaffected.
D000818:Animals; D002452:Cell Count; D002465:Cell Movement; D004804:Eosinophils / Q000473:pathology; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D007545:Isoproterenol / Q000494:pharmacology* / Q000627:therapeutic use; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D009000:Monocytes / Q000473:pathology; D009504:Neutrophils / Q000473:pathology; D051381:Rats
D007545:Isoproterenol