Modification of adriamycin cardiotoxicity by Damvar.
In experiments performed in mice, Adriamycin (15 mg/kg i. p.) produced serious damage of the heart muscle. Damvar (2 x 200 mg/kg orally) a new cytostatic drug combined with Adriamycin decreased conspicuously its cardiotoxicity.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D004317:Doxorubicin / Q000633:toxicity*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D006331:Heart Diseases / Q000139:chemically induced*; D008297:Male; D051379:Mice; D011744:Pyrimidinones / Q000494:pharmacology*
D000970:Antineoplastic Agents; D011744:Pyrimidinones; C019161:damvar; D004317:Doxorubicin