Two novel prolactin release-inhibiting 8 alpha-amino-ergolines.
Prolactin secretion inhibition and changes in striatal dopamine metabolism in rats were compared after the administration of 8 alpha-amino-ergoline CH 29-717 and 2 derivates. CQ 32-084 was similar to but less potent than CH 29-717, while 32-085, the l-methyl derivative, showed delayed dopaminomimetic effects.
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D010064:Embryo Implantation / Q000187:drug effects; D004873:Ergolines / Q000494:pharmacology*; D005260:Female; D007774:Lactation / Q000187:drug effects; D011247:Pregnancy; D011388:Prolactin / Q000378:metabolism*; D051381:Rats; D013329:Structure-Activity Relationship
D004873:Ergolines; D015102:3,4-Dihydroxyphenylacetic Acid; D011388:Prolactin; D004298:Dopamine