[Subacute sclerosing panencephalitis. A case with a prolonged course in an adult. Isolation and characteristics of a "defective" measles virus (author's transl)].
A 33-year-old man had a 6-year history of clinical signs suggesting multiple sclerosis : visual lesion at 27 years of age, cerebellar and visual disturbances at 31, which partly regressed, lymphocytosis and increased-gammaglobulin levels in the cerebrospinal fluid. Biological and anatomical (optical and ultrastructural) examinations gave results typical of a subacute sclerosing panencephalitis. A cytopathogenic measles virus was isolated from a cerebral biopsy specimen. The agent was transmissable to vero cells by co-culture but infectivity was always related to the cells and was therefore an incomplete viral infection. Virus-like particles were found in the nucleus and cytoplasm after electron microscopy examination of the co-cultures. Biochemical tests demonstrated that the viral proteins were all synthesized except hemagglutinin, which is a characterist abnormality of a "defective" measles virus.
D000328:Adult; D001921:Brain / Q000382:microbiology / Q000473:pathology; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D008459:Measles virus / Q000302:isolation & purification* / Q000378:metabolism / Q000648:ultrastructure; D009103:Multiple Sclerosis / Q000175:diagnosis; D013344:Subacute Sclerosing Panencephalitis / Q000209:etiology* / Q000382:microbiology / Q000473:pathology
Panencéphalite sclérosante subaiguë. Un cas d'évolution prolongée chez l'adulte - Isolement et caractérisation d'un virus rougeoleux "défectif".