Measles antibodies and histocompatibility types in multiple sclerosis.
Measles antibody titres and HLA antigens were determined in 71 White and 11 Coloured multiple sclerosis (MS) patients and 71 White and 11 Coloured age and sex-matched controls. Measles antibody titres were determined by the hemagglutination inhibition test and HLA antigens were determined serologically by a micro-lymphocytotoxicity test. Measles antibody titres were significantly higher in MS than in control cases and this was true for both female and male patients. No association was observed between the HLA antigens, especially HLA-A3 or HLA-B7 and measles antibody titres in the sera of MS patients or controls.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis*; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D006801:Humans; D008297:Male; D008459:Measles virus / Q000276:immunology*; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000453:epidemiology / Q000276:immunology*; D013019:South Africa
D000914:Antibodies, Viral; D006680:HLA Antigens