title: Cytotoxic principles from the sap of Kalmia latifolia.
abstract: Examination of the sap of Kalmia latifolia has revealed Grayanotoxin I (1), phloretin (3), and 2',6'-dihydroxy-4-methoxyacetophenone (5) as cytotoxic components. Twenty-one dihydrochalcones have been synthesized and tested for cytotoxic activity. 2'3,3'4,4'-Pentahydroxydihydrochalcone (8) has been found to be cytotoxic and to have marginal activity in vivo. Seven new dihydrochalcones are described.
mesh_terms: D000818:Animals; D002277:Carcinoma; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D007928:Lethal Dose 50; D051379:Mice; D009062:Mouth Neoplasms; D010944:Plants / Q000032:analysis*; D014118:Toxins, Biological / Q000302:isolation & purification / Q000633:toxicity*
chemical_list: D014118:Toxins, Biological