Studies on antibiotics BN-227 and BN-227-F, new antibiotics. I. Taxonomy, isolation and characterization.
The two new antibiotics, BN-227 and BN-227-F, were isolated from the fermentation broth of Pseudomonas sp. BN-227. BN-227 has a molecular formula C7H9NO3, and melts at 115 degrees C. BN-227-F has a molecular formula C21H24N3O9Fe, and melts at 156 degrees C. BN-227-F is a chelate compound consisting of three similar ligands (antibiotic BN-227) and ferric ion. The two antibiotics have antimicrobial activity against Gram-positive and Gram-negative bacteria.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D005285:Fermentation; D007928:Lethal Dose 50; D051379:Mice; D011549:Pseudomonas / Q000145:classification / Q000378:metabolism* / Q000648:ultrastructure; D011728:Pyridones / Q000096:biosynthesis / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D011728:Pyridones