Inflammatory response linked to oxazolone-indued cutaneous basophil hypersensitivity: effect of different immunomodulator and anti-inflammatory drugs.
The potency of cytostatic and anti-inflammatory drugs was tested on the oxazolone-induced cutaneous basophil hypersensitivity (CBH) in mice. The challenge reaction was performed early after sensitization in order to minimize B-cell expression; exudative and cellular infiltration was estimated 6 h, 24 h and 48 h after challenge. The potency of drugs was tested at three different periods of immunization: 2 days before or after sensitization or before challenge. Cytostatics act mainly when cells are being committed, a corticoid acts on inflammation linked to committed cells, NSAIDs show inconstant anti-inflammatory effects on this test. D-Penicillamine and levamisole act in the same depressive profile in normal animals. Thus the CBH model appears to be relevant in studying drug activities on inflammation linked to T-cell expression.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001491:Basophils / Q000276:immunology; D004342:Drug Hypersensitivity / Q000503:physiopathology*; D006968:Hypersensitivity, Delayed / Q000503:physiopathology*; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008297:Male; D051379:Mice; D010080:Oxazoles / Q000494:pharmacology*; D010081:Oxazolone / Q000494:pharmacology*; D012867:Skin / Q000166:cytology / Q000276:immunology; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D010080:Oxazoles; D010081:Oxazolone