High-performance liquid chromatographic determination of the nitroimidazole azanidazole in human plasma and urine.
Azanidazole can be measured in plasma and urine by reversed-phase high-performance liquid chromatography employing UV detection. Peak mean plasma concentrations of azanidazole, of 267 ng/ml, occurred at 1.5 h after single oral doses to human subjects, and declined with a half-life of 0.8 h. Less than 0.5% of the dose was excreted in the urine as unchanged drug. Metabolites of azanidazole were also detected by the procedures used.
D002851:Chromatography, High Pressure Liquid / Q000379:methods; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008832:Microchemistry; D009593:Nitroimidazoles / Q000097:blood* / Q000652:urine
D009593:Nitroimidazoles; C023624:azanidazole