Neuropharmacological activity of newly-synthethized derivatives of 3,3-diethyl-2,4-pyridinedione. III. N-Acyl derivatives of 3,3-diethyl-2,4-pyridinedione.
Neuropharmacological screening of five newly-synthesized derivatives of 3,3-diethyl-2,4-pyridinedione was carried out on albino mice. It was found that the N-acyl derivatives have a central depressive effect which is different in character compared with the effect of diethylpyridinedione. The compounds possess no hypnotic effect. All compounds potentiate hexobarbital sleep, while 1-(4-nitrobenzoyl)-3,3-diethyl-2,4-pyridinedione, 1-carbophenoxy-3,3-diethyl-2,4-pyridinedione inhibit the amphetamine-stimulated motor activity. 1-(4-nitrobenzoyl)-diethylpyridinedione manifests good analgetic effect (in the test with intraperitoneal administration of glacial acetic acid), while diethylpyridinedione increases the number of the abdominal spasms. The compounds studied manifest no anticonvulsive activity in corazol convulsions.
D000700:Analgesics; D000818:Animals; D000927:Anticonvulsants; D001921:Brain / Q000187:drug effects; D006591:Hexobarbital / Q000494:pharmacology; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D011619:Psychotropic Drugs / Q000138:chemical synthesis*; D011728:Pyridones / Q000138:chemical synthesis / Q000494:pharmacology*; D012890:Sleep / Q000187:drug effects
D000700:Analgesics; D000927:Anticonvulsants; D011619:Psychotropic Drugs; D011728:Pyridones; C005589:pyrithyldione; D006591:Hexobarbital