title: [Effectiveness of levamisole and oxyclozanide in paramphistomiasis in sheep and cattle].
abstract: The antiparasitic effectiveness of Levamizole and Oxyclozamide in the control of paramphistomatosis in sheep and cattle was studied. Experiments were performed in the 1975--1978 period with 1880 sheep and 132 cattle naturally invaded by P. microbothrium. The two drugs were administered orally in the following doses: Levamizole -- 7.5 mg/kg, Oxyclozanide -- 15 mg/kg for sheep and 10 mg/kg for cattle. A part of the experimental animals were treated by the combined drug Nilzan and received the above mentioned doses of both chemico-therapeutic means. Results were scored by ovoscopic investigation on the 10th and 15th day post treatment and by helminthological investigation on a part of the animals. Egg deposition was followed on 1415 sheep in the course of 4 months. A comparatively low effectiveness of Levamizole was established, namely U = 15--50%, IU = 81.56--99.40% and a good effectiveness of Oxyclozanide application, namely -- U = 30--80%, IU = 73.94-- 99.40% for sheep, and U = 0--50%, IU = 74.84--89.97% for cattle. Highest effectiveness was observed following the application of the combined drug Nilzan -- U = 47.7--92.0%, IU = 89.07--99.98% for sheep, and U = 20--73.20%, IU = 99.32--99.96% for cattle. The enhanced effectiveness of Nilzan application is considered by the authors as a result of synergism of the two chemico-therapeutic means.
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D004338:Drug Combinations; D004341:Drug Evaluation / Q000662:veterinary; D005260:Female; D007978:Levamisole / Q000008:administration & dosage / Q000627:therapeutic use*; D010097:Oxyclozanide / Q000008:administration & dosage / Q000627:therapeutic use*; D012457:Salicylamides / Q000627:therapeutic use*; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy*; D013997:Time Factors; D014201:Trematode Infections / Q000662:veterinary*
chemical_list: D004338:Drug Combinations; D012457:Salicylamides; D010097:Oxyclozanide; D007978:Levamisole
vernacular_title: Efektivnost na levamizole i oxyclozanide sreshtu paramfistomatozata po ovtsete i govedata.