[Value of the intravenous route for the use of phenobarbital in asphyxiated full term newborn infants].
Phenobarbital (20 mg/kg) was given intravenously to asphyxiated full term neonates who were less than 48 hours old. Further doses were given for 4 days (5 mgs/kg/d). Plasma levels were within the therapeutic range from 5 to 36 hours after the first injection but the maintenance dose always resulted in overdose by 5th day. The exact maintenance dose needs to be determined.
D001238:Asphyxia Neonatorum / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007275:Injections, Intravenous; D008297:Male; D010634:Phenobarbital / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use
D010634:Phenobarbital
Intérêt de la voie intraveineuse pour l'utilisation du phénobarbital chez le nouveau-né à terme asphyxié.