The role of danazol in the management of precocious puberty.
The management, investigation and treatment of 12 children with precocious puberty is described. Danazol, a synthetic derivative of ethisterone, has been used over a period of 3 1/2 years. Its clinical, endocrine and biochemical effects have been evaluated. Danazol ha a very useful clinical effect in controlling the development of secondary sexual features but does not modify the rapid linear growth and skeletal maturity seen in this condition.
D015068:17-Ketosteroids / Q000652:urine; D001827:Body Height / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D003613:Danazol / Q000627:therapeutic use*; D004569:Electroencephalography; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007223:Infant; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D011245:Pregnadienes / Q000627:therapeutic use*; D011629:Puberty, Precocious / Q000097:blood / Q000188:drug therapy* / Q000652:urine
D015068:17-Ketosteroids; D011245:Pregnadienes; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D003613:Danazol