The Ah locus: biochemical basis for genetic differences in brain tumor formation in mice.
Allelic differences at the Ah locus are showen to exist in the mouse brain. This finding probably explains inbred mouse strain differences in polycyclic hydrocarbon tumorigenesis of the brain described more than 35 years ago and may be important in understanding the etiology of genetic differences in certain human intracranial neoplasms.
D000483:Alleles; D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000096:biosynthesis* / Q000235:genetics; D001932:Brain Neoplasms / Q000139:chemically induced / Q000235:genetics*; D002874:Chromosome Mapping; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis / Q000235:genetics; D004790:Enzyme Induction; D005796:Genes; D008297:Male; D008748:Methylcholanthrene; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000235:genetics
D008748:Methylcholanthrene; D003577:Cytochrome P-450 Enzyme System; D001189:Aryl Hydrocarbon Hydroxylases