Effects of methylmercuric chloride intoxication on the intracellular activity of lysosomal enzymes in rat liver and brain.
The activity of the lysosomal enzymes of rat liver after a single intraperitoneal injection of methylmercuric chloride (5.0 mg/kg) was enhanced in the nuclear fraction during early post-injection (2 hr to 7 days), while it decreased in the mitochondrial fraction and increased in the lysosomal fraction during late post-injection (14 days). Rat brain activity, however, was reduced in the nuclear, mitochondrial and lysosomal fractions during late post-injection (14 days). A high accumulation of total mercury was observed in the liver during early post-injection (36 hr and 7 days) while similar accumulation in the brain occured during late post-injection (7 days and 14 days). Both the mercury burdens and the enzyme activities of the rat liver and brain returned to normal levels within 30 days.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology* / Q000648:ultrastructure; D004798:Enzymes / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000648:ultrastructure; D008247:Lysosomes / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D008628:Mercury / Q000378:metabolism; D008767:Methylmercury Compounds / Q000506:poisoning*; D051381:Rats; D013997:Time Factors; D014018:Tissue Distribution
D004798:Enzymes; D008767:Methylmercury Compounds; D008628:Mercury