LSD's effect on neuron populations in visual cortex gauged by transient responses of extracellular potassium evoked by optical stimuli.
The effects of systemic LSD (10--25 micrograms/kg) on visually evoked [K+]o responses from the striate cortex have been investigated in cats. Elevation of [K+]o was dependent on the orientation, and direction of stimulus movement and showed ocular dominance. LSD most commonly produced a depression of [K+]o transients and a deterioration in their directional selectivity. These observations suggest that the effect of LSD is to produce a net depression in visually evoked neuronal firing.
D000818:Animals; D002415:Cats; D005071:Evoked Potentials / Q000187:drug effects; D005110:Extracellular Space / Q000378:metabolism; D008238:Lysergic Acid Diethylamide / Q000494:pharmacology*; D009039:Motion Perception / Q000187:drug effects; D009949:Orientation / Q000502:physiology; D011188:Potassium / Q000378:metabolism*; D014793:Visual Cortex / Q000187:drug effects* / Q000378:metabolism; D014796:Visual Perception / Q000187:drug effects*
D008238:Lysergic Acid Diethylamide; D011188:Potassium