title: Late changes in biochemistry and blood flow in rat brain locally exposed to 30, 40, or 60 Gy.
abstract: Rat brain was exposed to 30, 40 or 60 Gy of roentgen rays and different biochemical and physiologic parameters were assayed from one day to 2 years. The most important changes noted were an intermediate increase in DNA, an intermediate to late--dependent on dose--increase in collagen, a decrease in sialic acid, an early to intermediate increase in serotonin, an increase in cathepsin, an early depression, and intermediate enhancement and a late decrease in alpha amino isobutyrate uptake by brain, and an early reduction, an intermediate--and sometimes late--increase in blood flow. These changes suggest that all three principal systems 2n the brain, nerve cells, glia and vascular system, participate in late changes.
mesh_terms: D000367:Age Factors; D000818:Animals; D001835:Body Weight / Q000528:radiation effects; D001923:Brain Chemistry / Q000528:radiation effects*; D002560:Cerebrovascular Circulation / Q000528:radiation effects*; D004247:DNA / Q000378:metabolism; D009929:Organ Size / Q000528:radiation effects; D011829:Radiation Dosage; D051381:Rats
chemical_list: D004247:DNA