title: [Biologically active N-Mannich bases of isatin-3-(phenyl)-imines (author's transl)].
abstract: By the condensation of isatin and 5-nitroisatin with substituted aromatic amines, isatin- and 5-nitroisatin-3-(phenyl)-imines (azomethines) are formed which are converted into N-Mannich-bases by aminomethylation and may be formulated as azomethines with E configuration. A biotest of Lepidium sativum L. was used to prove mitodepressive properties. Some compounds showed a significant growth-inhibiting activity. It was found that a change in activity is produced by condensation on the carbon atom in position 3 and by aminomethylation on the nitrogen atom in the isatin nucleus.
mesh_terms: D007097:Imines / Q000138:chemical synthesis / Q000494:pharmacology; D007211:Indoles / Q000138:chemical synthesis*; D007510:Isatin / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D008352:Mannich Bases; D008938:Mitosis / Q000187:drug effects; D010944:Plants
chemical_list: D007097:Imines; D007211:Indoles; D008352:Mannich Bases; D007510:Isatin
vernacular_title: Biologisch aktive N-Mannich-Basen von Isatin-3-(phenyl)iminen.