Genetic variation in alkaline phosphatase of the house mouse (Mus musculus) with emphasis on a manganese-requiring isozyme.
Genetic variation among inbred strains is described for electrophoretic migration of alkaline phosphatase from intestine, kidney, blood plasma, and three isozymes of liver. A manganese-requiring isozyme of liver and kidney unaffected by neuraminidase is described, and the locus controlling variation in this isozyme is designated Akp-1. Data from recombinant inbred strains place the locus on chromosome 1 at a distance of 3.6 +/- 2.9 cM from the M1s locus on the side distal to the centromere. Test-cross data show the following gene order and recombination percentages: Dip-1 19.0 +/- 3.8% Lp 7.4 +/- 2.2% Akp-1.
D000469:Alkaline Phosphatase / Q000097:blood / Q000235:genetics*; D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D005796:Genes; D014644:Genetic Variation; D007422:Intestines / Q000201:enzymology; D007527:Isoenzymes / Q000235:genetics*; D007668:Kidney / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D008345:Manganese / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D011995:Recombination, Genetic
D007527:Isoenzymes; D008345:Manganese; D000469:Alkaline Phosphatase