The failure of hydrogen peroxide to improve function in ischemically depressed myocardium.
The hypothesis that hydrogen peroxide might lend inotropic support to ischemically depressed myocardium was critically tested in a canine model. A coronary branch was perfused at reduced flow to depress mechanical function. Since hydrogen peroxide infusion into the perfusate failed to alter the segment's contractile force, it was concluded that the previously described beneficial effects of hydrogen peroxide infusions are probably not related to a restoration of contractility in ischemic myocardium.
D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects; D003327:Coronary Disease / Q000503:physiopathology*; D004285:Dogs; D005260:Female; D006321:Heart / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects
D006861:Hydrogen Peroxide; D007545:Isoproterenol