title: Effects of acute lactic acidosis on some hemodynamic and hematologic values in three cows.
abstract: Some hemodynamic and hematologic effects of acute experimental lactic acidemia in 3 healthy cows are presented. Lactic acidemia was induced by intravenous infusion of a 10% solution of racemic lactic acid. The prominent features of the acidification of the blood were increases in carotid artery blood pressure and responses to intravenously injected norepinephrine, slight bradycardia and slight hyperventilation. Intravascular hemolysis with hemoglobinuria was a constant finding. Otherwise, no adverse effects of the acidemia were noted. These changes were paralleled by a progressive fall in arterial blood pH, base excess and PCO2 and increasing venous blood L (+)-lactate concentrations A reasonable explanation for the hemodynamic effects of the acidemia is peripheral vasoconstriction elicited by either stimulation of the sympathetic nervous system or increased sensitivity of vasoconstrictive receptors. The results are discussed with special reference to primary lactic acidosis encountered in grain engorgement in ruminants and to the secondary lactic acidosis of shock. These conditions are characterized by hemoconcentration and hypovolemia. Therefore, the results of this study of healthy normovolemic cows may not be valid in the severely dehydrated, hemoconcentrated and acidemic cow as hypotension is reported in the literature in connection with ruminal acidosis in sheep.
mesh_terms: D000138:Acidosis / Q000503:physiopathology*; D000818:Animals; D001774:Blood Chemical Analysis; D001794:Blood Pressure / Q000187:drug effects; D002417:Cattle / Q000097:blood* / Q000502:physiology; D004573:Electrolytes / Q000097:blood; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics; D006985:Hyperventilation / Q000139:chemically induced; D007773:Lactates / Q000097:blood* / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology
chemical_list: D004573:Electrolytes; D007773:Lactates; D009638:Norepinephrine