Pulmonary function in rabbits with BCG-induced lung disease.
This study was performed to determine whether the lung histological changes which occur in rabbits following intravenous injection of killed Bacilli Calmette-Guérin (BCG) are accompanied by measurable changes in pulmonary function. We measured pulmonary function in New Zealand white rabbits 3 weeks after intravenous injection of BCG and in normal rabbits. After a tracheostomy and carotid artery catheterization was performed, each anesthetized rabbit was placed in a body plethysmograph for pulmonary function testing. Following the measurements, the lungs were removed for weighing and histological evaluation. In the BCG-treated rabbits, the lung weight/body weight ratios were 152% greater, the pulmonary resistance was 104% higher, dynamic compliance was 45% lower, minute ventilation was 28% greater, and the delta AaPO2 gradient was 13 torr higher than in the normal control rabbits. Histological evaluation of the BCG-treated animals revealed diffuse pulmonary involvement with non-caseating granulomas.
D000403:Airway Resistance; D000818:Animals; D001500:BCG Vaccine; D001784:Blood Gas Analysis; D004195:Disease Models, Animal; D005260:Female; D008168:Lung / Q000473:pathology / Q000503:physiopathology*; D008170:Lung Compliance; D008297:Male; D011014:Pneumonia / Q000473:pathology / Q000503:physiopathology*; D011817:Rabbits
D001500:BCG Vaccine