title: Inhibition of aminotransferase enzyme systems by gabaculine.
abstract: Addition of gabaculine to brain and liver extracts caused great inhibition of GABA-T activity, a much lesser but still significant inhibition of ALA-T activity, and very little inhibition of ASP-T activity. In contrast, intramuscular administration of gabaculine to mice resulted in considerable inhibition of all three enzyme activities in liver, the order of sensitivity being ALA-T greater than GABA-T greater than ASP-T. The effect of the administered gabaculine on the brain enzyme activities was more along the lines seen in the in vitro experiments but, even here, the relative sensitivities of GABA-T and ALA-T to the inhibition were much more similar than might have been predicted from the in vitro experiments.
mesh_terms: D000612:4-Aminobutyrate Transaminase / Q000037:antagonists & inhibitors; D000410:Alanine Transaminase / Q000037:antagonists & inhibitors; D000818:Animals; D001219:Aspartate Aminotransferases / Q000037:antagonists & inhibitors; D001921:Brain / Q000201:enzymology*; D003509:Cyclohexanecarboxylic Acids / Q000494:pharmacology*; D003514:Cyclohexylamines / Q000494:pharmacology; D008099:Liver / Q000201:enzymology*; D008297:Male; D051379:Mice; D000637:Transaminases / Q000037:antagonists & inhibitors*
chemical_list: D003509:Cyclohexanecarboxylic Acids; D003514:Cyclohexylamines; D000637:Transaminases; D001219:Aspartate Aminotransferases; D000612:4-Aminobutyrate Transaminase; D000410:Alanine Transaminase