Carcinogenic effect of N-ethyl- and N-amyl-N-nitrosourethans on female Donryu rats.
Carcinogenic effect of N-ethyl-N-nitrosourethan (ENUR) and N-amyl-N-nitrosourethan (ANUR) was examined by continuous oral administration or topical application to female Donruy rats. Oral administration of 100 ppm solution of ENUR induced 100% of tumors in the forestomach, 46%, 80%, 71%, and 51% in the oral cavity and pharynx, esophagus, duodenum, and liver, respectively. On the other hand, the incidence of forestomach tumors was 78%, that of oral cavity and pharynx, and esophagus was 93% and 98%, respectively, in rats given 400 ppm suspension of ANUR. In addition, topical application of ENUR induced tumors of the skin as well as tumors of the forestomach and liver.
D000284:Administration, Oral; D000287:Administration, Topical; D000818:Animals; D002277:Carcinoma / Q000139:chemically induced; D004379:Duodenal Neoplasms / Q000139:chemically induced; D004938:Esophageal Neoplasms / Q000139:chemically induced; D005260:Female; D009062:Mouth Neoplasms / Q000139:chemically induced; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D009605:Nitrosomethylurethane / Q000008:administration & dosage / Q000031:analogs & derivatives*; D010212:Papilloma / Q000139:chemically induced; D010610:Pharyngeal Neoplasms / Q000139:chemically induced; D051381:Rats; D013274:Stomach Neoplasms / Q000139:chemically induced; D014062:Tongue Neoplasms / Q000139:chemically induced; D014520:Urethane / Q000031:analogs & derivatives*
C022881:N-ethyl-N-nitrosourethane; D014520:Urethane; D009605:Nitrosomethylurethane; C022293:N-amyl-N-nitrosourethane