Neuropharmacological activity of new derivatives of 3,3-diethyl-2,4-pyridinedione. IV. 1-alkyl derivatives of 3,3-diethyl-2,4-pyridinedione.
Neuropharmacological screening of five 1-alkyl derivatives of 3,3-diethyl-2,4-pyridinedione was performed on male albino mice. The substances studied manifest very good analgesic effect in the test involving intraperitoneal injection of glacial acetic acid. 1-Alkyl derivatives have no hypnotic effect. They potentiate hexobarbital anaesthesia (with the exception of 1-/4'-/2''-hydroxyethyl/-piperazinylpropano/-3,3-diethyl-2,4-pyridinedione). 1-/2-morpholinoethyl/-3,3-diethyl-5-hydroxymethyl-2,4-pyridinedione and 1-/2'-morpholinoethyl/-3,3-diethyl-5-/3',4',5'-trimethoxybenzoyloxymethyl/-2,4-pyridinedione inhibit the amphetamine-stimulated motor activity. The newly-synthesized substances have no anticonvulsant action in corazol convulsions. 1-Alkyl derivatives are found to manifest a central depressive action, differing from that of diethylpyridinedione.
D000700:Analgesics; D000818:Animals; D000927:Anticonvulsants; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009420:Nervous System / Q000187:drug effects*; D011728:Pyridones / Q000138:chemical synthesis / Q000494:pharmacology*; D012890:Sleep / Q000187:drug effects
D000700:Analgesics; D000927:Anticonvulsants; D011728:Pyridones; C005589:pyrithyldione