Use of technetium-99m as a radioactive label to study migratory patterns of leukocytes.
Technetium-99m had been used as a radioactive label to study the migratory patterns of neutrophils. In a previous in vitro study, neutrophils were labeled with Tc-99m and infused into patients with and without various hematological disorders. Increased pulmonary localization was detected by scintillation camera within 10 min; this decreased gradually within 3 hr. Accumulation was seen in the liver and spleen at 3 hr. The same results were noted by using neutrophils labeled with Tc-99m sulfur colloid. In a patient with severe ulceration in the oral cavity, due to acute leukemia, Tc-99m-labeled transfused neutrophils that were collected by filtration leukopheresis were concentrated in the infected lesions.
D000328:Adult; D000368:Aged; D002465:Cell Movement; D005260:Female; D005891:Gingivitis / Q000000981:diagnostic imaging; D006801:Humans; D007267:Injections; D007553:Isotope Labeling; D007962:Leukocytes / Q000000981:diagnostic imaging* / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000000981:diagnostic imaging; D011877:Radionuclide Imaging / Q000379:methods*; D013455:Sulfur; D013667:Technetium / Q000378:metabolism; D014018:Tissue Distribution
D013455:Sulfur; D013667:Technetium