Elimination of allopurinol by the perfused rat liver preparation.
The elimination of allopurinol was studied in the perfused rat liver preparation. When tracer input [14C]-allopurinol concentrations (0.04 to 0.17 microgram/ml) were delivered under constant flow rate (10 ml/min/liver) only once through the rat liver, the steady-state hepatic extraction ratios were high (0.87 +/- 0.03). But at higher input allopurinol concentrations (3.3 to 17 micrograms/ml), concentration-dependent elimination of allopurinol was observed. The steady-state hepatic extraction ratio was drastically reduced with increases in input concentrations. At very high input concentrations of allopurinol (17 micrograms/ml) the hepatic extraction ratio was virtually zero. These findings inferred that the rat liver may play only a moderate role in the elimination of allopurinol in the intact animal.
D000493:Allopurinol / Q000378:metabolism*; D000818:Animals; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism*; D008297:Male; D010117:Oxypurinol / Q000378:metabolism; D051381:Rats; D013997:Time Factors
D000493:Allopurinol; D010117:Oxypurinol