[Relationship between the results of glucose tolerance test and plasma content of immunoreactive insulin in the relatives of patients with juvenile form of diabetes mellitus].
Relatives (67) of patients with a juvenile form of diabetes mellitus and in 17 persons of control group were investigated. Hyperinsulinemia was revealed in close relatives and in persons with adiposity. The highest insulin response to glucose load was in persons with "doubtful" glucose tolerance test results. Insulinemic curve was flattened in the group of persons with latent and particularly with manifest diabetes. On the basis of the results obtained and the literature data a conclusion was drawn that hyperinsulinemia was one of the significant indices of disturbances in the regulation of insulin secretion in persons with hereditary aggravation by diabetes mellitus and could serve as a diagnostic index of the early stages of this disease.
D000293:Adolescent; D000328:Adult; D000941:Antigens; D003920:Diabetes Mellitus / Q000235:genetics; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D005951:Glucose Tolerance Test; D006801:Humans; D006943:Hyperglycemia / Q000235:genetics*; D007328:Insulin / Q000097:blood*; D008875:Middle Aged; D011236:Prediabetic State / Q000235:genetics*
D000941:Antigens; D007328:Insulin
Zavisimost' mezhdu kharakterom testa na tolerantnost' k gliukoze i soderzhaniem immunoreaktivnogo insulina v plazme krovi u rodstvennikov bol'nykh s iunosheshkoĭ formoĭ sakharnogo diabeta.