Relationship of some open-field behaviors to amygdaloid kindled convulsions in Wistar rats.
Repeated low-intensity electrical stimulation (kindling) of the amygdala eventually produces convulsive behavior in animals. The present study examined the relationship between behaviors displayed in a novel open-field situation with behavioral characteristics of the kindled clonic convulsion (CC). Wistar rats were given two open-field tests and were subsequently kindled to clonic convulsions. A multiple regression analysis indicated that rats which urinated more often in the open-field tests tended to show longer latencies to CC onset. Thus, open-field urination was a significant predictor of latency to CC onset. It is suggested that an emotionality construct may be related to rate of kindling.
D000679:Amygdala / Q000502:physiology*; D000818:Animals; D004558:Electric Stimulation; D005106:Exploratory Behavior / Q000502:physiology*; D008297:Male; D009043:Motor Activity / Q000502:physiology; D051381:Rats; D011930:Reaction Time / Q000502:physiology; D012640:Seizures / Q000503:physiopathology*; D014554:Urination