Determination of clonazepam in human plasma by gas chromatography--negative ion chemical ionization mass spectrometry.
Our previously reported gas chromatographic--mass spectrometric assay for clonazepam using positive ion chemical ionization has been modified to employ negative ion chemical ionization. The sensitivity using this technique (less than 0.1 ng/ml) is approximately twenty times better than the positive ion chemical ionization procedure with similar precision. The method was used to determine the clonazepam plasma concentration in one human for 96 h following a single 2-mg dose of clonazepam.
D001570:Benzodiazepinones / Q000097:blood*; D002998:Clonazepam / Q000097:blood*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D006801:Humans; D013997:Time Factors
D001570:Benzodiazepinones; D002998:Clonazepam