title: Persistence in the mouse gut as an important factor in oral immunogenicity of strains of V. cholerae.
abstract: The immune responses of mice following oral vaccination with two strains of live V. cholerae have been examined. A strain which persisted in the small intestine was a superior local immunogen by comparison with another non-persisting strain. Local persistence and the ability to induce a local immune response appeared to be correlated, since the two vibrio strains elicited identical responses when given parenterally.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D022121:Cholera Vaccines / Q000008:administration & dosage / Q000276:immunology*; D005260:Female; D007117:Immunization, Secondary; D007413:Intestinal Mucosa / Q000382:microbiology; D007421:Intestine, Small / Q000382:microbiology*; D008070:Lipopolysaccharides / Q000276:immunology; D051379:Mice; D013045:Species Specificity; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000276:immunology; D014734:Vibrio cholerae / Q000254:growth & development* / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D022121:Cholera Vaccines; D008070:Lipopolysaccharides; D014613:Vaccines, Attenuated