p-Chloroamphetamine antagonism of cobaltous chloride-induced hypothermia in mice.
Serotonin levels were measured in the brains of mice at 2 h and 10 days following the administration of a single dose of 10 mg/kg, i.p. of p-chloroamphetamine HCl (PCA). A 44% reduction in the concentration of brain serotonin was noted 2 h after PCA injection. No significant change in brain serotonin was observed 10 days following PCA administration. The time course of the body temperature response to cobaltous chloride (25 mg/kg, i.p.) was recorded 60 min following pretreatment with PCA (10 mg/kg, i.p.). PCA reduced the hypothermic response by approximately 60%, presumably through the depletion of central 5-hydroxytryptamine.
D000662:Amphetamines / Q000494:pharmacology*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D001923:Brain Chemistry / Q000187:drug effects; D003035:Cobalt / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D008297:Male; D051379:Mice; D012701:Serotonin / Q000378:metabolism; D013997:Time Factors; D010133:p-Chloroamphetamine / Q000494:pharmacology*
D000662:Amphetamines; D012701:Serotonin; D003035:Cobalt; D010133:p-Chloroamphetamine