The value of kanamycin-colistin bladder instillations in reducing bacteriuria during intermittent catheterisation of patients with acute spinal cord injury.
Two groups of patients with acute spinal cord trauma had initial bladder management by standard non-touch techniques of intermittent catheterisation. Twenty-two patients (17 males and 5 females) had kanamycin-colistin solution instilled into the bladder at the end of each catheterisation, and 25 patients (21 males and 4 females) were not given these instillations. The incidence of significant bacteriuria during intermittent catheterisation of both males and females receiving the instillations was only half the incidence of those not receiving the instillations. Also, a significantly higher proportion of males receiving the instillations did not have any episodes of significant bacteriuria compared with those not receiving the instillations, and the same trend was evident in the small number of female patients. It is recommended that patients should have kanamycin-colistin bladder instillations when they are being intermittently catheterised.
D000208:Acute Disease; D001419:Bacteria / Q000302:isolation & purification; D001437:Bacteriuria / Q000209:etiology / Q000382:microbiology / Q000517:prevention & control*; D003091:Colistin / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007612:Kanamycin / Q000627:therapeutic use*; D008297:Male; D008826:Microbial Sensitivity Tests; D012996:Solutions; D013119:Spinal Cord Injuries / Q000628:therapy*; D001743:Urinary Bladder; D014546:Urinary Catheterization / Q000009:adverse effects* / Q000379:methods
D004338:Drug Combinations; D012996:Solutions; D007612:Kanamycin; D003091:Colistin