90-day sub-chronic inhalation toxicity of a mercapto-functional silicone oil in rats.
A mercapto-functional poly(dimethylsiloxane) silicone oil vapor (0.15 and 0.45 mg/l) was generated by passage of air through the heated oil and rats were subjected to these vapors over a 90-day period. An extensive pathological, clinical and hematological workup failed to demonstrate any significant effects of this exposure. In addition, weight gains over the experimental period were comparable to controls.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004129:Dimethylpolysiloxanes / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D005740:Gases; D007958:Leukocyte Count; D008297:Male; D009821:Oils / Q000008:administration & dosage / Q000633:toxicity*; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D012828:Silicones / Q000097:blood / Q000633:toxicity*; D013997:Time Factors
D004129:Dimethylpolysiloxanes; D005740:Gases; D009821:Oils; D012828:Silicones