The metabolism and excretion of 7-mono-0-(beta-hydroxyethyl) rutoside in the dog.
Following i.v. administration of mono-HR to the beagle, plasma levels of both mono-HR and its glucuronide conjugates fell rapidly, neither being detectable 8 h after injection. Following oral administration of 14C-mono-HR, mono-HR-glucuronide was detected in plasma, confirming the absorption of mono-HR, and low levels of 14C were detectable up to 72 h after dosage. Following either oral or i.v. administration of mono-HR, the major route of excretion was fecal elimination of the compound as its aglycone form. Urinary excretion was slight being less than 15% following i.v. dosage and 4% following oral administration. Metabolism of mono-HR was confined to glucuronidation and hydrolytic cleavage of the glycoside side chain. Ring fission products of mono-HR were not detected.
D000818:Animals; D004285:Dogs; D005243:Feces / Q000032:analysis; D005260:Female; D005965:Glucuronates / Q000032:analysis; D006896:Hydroxyethylrutoside / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism* / Q000652:urine; D007408:Intestinal Absorption; D012431:Rutin / Q000031:analogs & derivatives*; D013997:Time Factors
D005965:Glucuronates; D006896:Hydroxyethylrutoside; D012431:Rutin