Interaction between sulindac and warfarin: different results in normal subjects and in an unusual patient with a potassium-losing renal tubular defect.
While sulindac failed to affect significantly warfarin-induced hypoprothrombinemia in normal male volunteers, it markedly prolonged prothrombin time in a patient with a renal tubular defect who had been anticoagulated with warfarin. This difference in individual response with respect to a drug interaction illustrates the need to adjust information on drug interactions to the particular clinical circumstances and conditions under which drugs are coadministered.
D000328:Adult; D004347:Drug Interactions; D005260:Female; D006801:Humans; D007192:Indenes / Q000494:pharmacology*; D007674:Kidney Diseases / Q000378:metabolism*; D007684:Kidney Tubules / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010919:Placebos; D011188:Potassium / Q000378:metabolism*; D011517:Prothrombin Time; D013467:Sulindac / Q000494:pharmacology*; D013997:Time Factors; D014859:Warfarin / Q000097:blood / Q000494:pharmacology*
D007192:Indenes; D010919:Placebos; D013467:Sulindac; D014859:Warfarin; D011188:Potassium