Digoxin acute intoxication: evaluation of the efficiency of charcoal hemoperfusion.
Since there is no widely used method of reducing the severity of massive digoxin intoxication, the capacity of hemoperfusion with coated, activated charcoal to remove digoxin was evaluated in a case of suicidal digoxin ingestion (25 mg). Seven hours after ingestion the digoxin plasma level was equal to 8.9 ng/ml. This was decreased to 4.5 ng/ml after 6 hr hemoperfusion. The amount of digoxin adsorbed by the column represents 4.8% of the absorbed dose. At a blood flow rate of 170 ml/min, the mean digoxin clearance by hemoperfusion was 44.5 +/- 26.9 ml/min. From these results we conclude that charcoal hemoperfusion in acute digoxin intoxication is of little value.
D000328:Adult; D002606:Charcoal; D004077:Digoxin / Q000378:metabolism / Q000506:poisoning*; D005260:Female; D006464:Hemoperfusion / Q000379:methods; D006801:Humans; D014018:Tissue Distribution
D002606:Charcoal; D004077:Digoxin