title: Relationship between serum and saliva chloramphenicol concentrations.
abstract: The relationship between serum and saliva chloramphenicol (CAP) concentrations was evaluated in 27 paired specimens collected from 20 hospitalized patients during therapy with the drug. A significant (R = 0.80, P < 0.001) but variable relationship was found to exist. Serum protein binding of CAP was also evaluated (43.7 +/- 5.7% bound; N = 24). Differences in CAP binding did not apparently account for a significant portion of the variability in the observed saliva/serum CAP concentration ratios. The degree of variation observed indicated that saliva CAP concentrations could not be relied upon for the prediction of serum CAP concentrations.
mesh_terms: D000328:Adult; D002701:Chloramphenicol / Q000097:blood / Q000378:metabolism*; D006801:Humans; D011485:Protein Binding; D012463:Saliva / Q000378:metabolism*
chemical_list: D002701:Chloramphenicol