The effect of ethanol on the distribution of synaptic vesicles in cortical synaptosomes of the rat.
Ethanol was shown to cause a redistribution of synaptic vesicles in incubated synaptosomes. While the number of synaptosomes containing synaptic vesicles attached to the presynaptic membrane decreased markedly, an increase in the number of synaptosomes lacking membrane-vesicle associations was observed. The findings support the possibility of a presynaptic action of ethanol and point to the role of membrane-attached vesicles in synaptic transmission.
D000818:Animals; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D008297:Male; D051381:Rats; D013347:Subcellular Fractions / Q000187:drug effects; D013572:Synaptic Vesicles / Q000187:drug effects*; D013574:Synaptosomes / Q000648:ultrastructure*
D000431:Ethanol