Kidney kallikrein and phospholipase activities in Milan spontaneously hypertensive rats.
Renal kallikrein and phospholipase activities were evaluated in a strain of spontaneously hypertensive rats developed by Dr. Bianchi in Milan (MHR). MHR showed lower than normal kallikrein and phospholipase activities before, at 3 weeks of age and following the development of hypertension. Kallikrein and phospholipase activities were directly correlated both in normotensive and spontenously hypertensive rats. The data suggest that MHR have a genetic defect in kallikrein and phospholipase activities, which may play a pathogenetic role in the development of high blood pressure.
D000818:Animals; D006973:Hypertension / Q000201:enzymology* / Q000209:etiology / Q000235:genetics; D007610:Kallikreins / Q000378:metabolism*; D007668:Kidney / Q000201:enzymology*; D010740:Phospholipases / Q000378:metabolism*; D051381:Rats
D010740:Phospholipases; D007610:Kallikreins