Laboratory diagnosis of HB CC-alpha-thalassemia.
Routine laboratory investigations of hemoglobinopathies include Hb electrophoresis for abnormal hemoglobins, determination of Hb A2 (alpha 2 delta 2) for beta-thalassemia traits, staining for Hb H (beta 4) inclusions for alpha-thalassemia traits and estimation of Hb F (alpha 2 lambda 2) for the presence of hereditary persistence of fetal hemoglobin genes (HPFH). Frequently, analytical column chromatography and alpha/beta hemoglobin chain synthesis are used in the studies of more complicated hemoglobinopathies. This communication outlines the procedures used in this laboratory for the diagnosis of a case of Hb CC-alpha-thalassemia.
D000328:Adult; D004592:Electrophoresis, Starch Gel; D006443:Hemoglobin A2 / Q000032:analysis; D006444:Hemoglobin C / Q000032:analysis; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D008297:Male; D013789:Thalassemia / Q000175:diagnosis*
D006454:Hemoglobins; D006444:Hemoglobin C; D006443:Hemoglobin A2