Potential antiinflammatory compounds. 3. Compounds derived from acenaphthene and indan.
Compounds having acenaphthene and indan as their parent nuclei were synthesized for antiinflammatory testing. Compounds which showed activity were 1-phenyl-5-acenaphthenylacetic acid and its alpha-methyl derivative (carrageenan rat paw edema) and the same alpha-methylacenaphthenylacetic acid and 2-(4-chlorobenzylidene)-3-oxo-5-indanacetic acid and its alpha-methyl derivative (rat adjuvant arthritis). None of the compounds was more active than the control compounds phenylbutazone and indomethacin.
D000073:Acenaphthenes / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis*; D001169:Arthritis, Experimental / Q000503:physiopathology; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000503:physiopathology; D007189:Indans / Q000138:chemical synthesis* / Q000494:pharmacology; D007192:Indenes / Q000138:chemical synthesis*; D051381:Rats
D000073:Acenaphthenes; D000893:Anti-Inflammatory Agents; D007189:Indans; D007192:Indenes; D002351:Carrageenan