High incidence of the silent allele at cholinesterase locus I in Vysyas of Andhra Pradesh (S. India).
Four-hundred and ninety individuals belonging to the Vysya caste from Andhra Pradesh were screened for pseudocholinesterase variants at the E1 and E2 locus. A high incidence of the silent allele (gene frequency=0.1112) was recorded with homozygotes exceeding 2% of the population. Dibucaine- and fluoride-resistant alleles were found in a heterozygous form with the usual alleles in four individuals each. No C5+ variant at the E2 locus was found.
D000483:Alleles; D002091:Butyrylcholinesterase / Q000235:genetics*; D002802:Cholinesterases / Q000235:genetics*; D002874:Chromosome Mapping; D005006:Ethnicity; D005787:Gene Frequency; D014644:Genetic Variation; D006720:Homozygote; D006801:Humans; D007194:India
D002091:Butyrylcholinesterase; D002802:Cholinesterases