A simple method to control Brugia timori by diethylcarbamazine administration.
The results of mass treatment using 50 mg diethylcarbamazine per kg body-weight followed one year later by short term selective re-treatment in a highly endemic area of Brugia timori are described. The criteria for selection of re-treatment are simple and practical for use in rural areas. The microfilaria rate by finger prick decreased from 24% to 0 and by Nuclepore filtration from 30% to 2.5%. The disease rates were also affected favourably. 88% of persons receiving the drug reacted to treatment, this percentage slightly exceeding the total filarial infection rate (71%). The prevalence, onset, duration and nature of side reactions are briefly discussed and related to the presence of microfilaraemia and disease manifestations among the study population.
D002009:Brugia; D004049:Diethylcarbamazine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005368:Filariasis / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007214:Indonesia; D008205:Lymphangitis / Q000209:etiology; D008209:Lymphedema / Q000209:etiology
D004049:Diethylcarbamazine