title: Prostaglandin E antagonist activity of 11-deoxy-16,16-trimethyleneprostaglandin E1.
abstract: 11-Deoxy-16,16-trimethyleneprostaglandin E1 is a potent inhibitor of prostaglandin E-induced contractions of the gerbil colon. The antagonism is directed specifically against the prostaglandin E receptor and is not manifested when contractions are induced by either prostaglandin F2 alpha or acetylcholine.
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000527:Alprostadil / Q000031:analogs & derivatives; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D003106:Colon / Q000187:drug effects; D005849:Gerbillinae; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D011458:Prostaglandins E / Q000037:antagonists & inhibitors*; D011459:Prostaglandins E, Synthetic / Q000031:analogs & derivatives* / Q000494:pharmacology; D011460:Prostaglandins F / Q000494:pharmacology; D011982:Receptors, Prostaglandin / Q000187:drug effects
chemical_list: D011458:Prostaglandins E; D011459:Prostaglandins E, Synthetic; D011460:Prostaglandins F; D011982:Receptors, Prostaglandin; C024110:11-deoxy-16,16-trimethyleneprostaglandin E1; D000527:Alprostadil; D000109:Acetylcholine