Antifertility activity of alpha-chlorohydrin (3-chloro-1, 2 propanediol, U-5897) on the female rats.
alpha-chlorohydrin administration brings about regression in the corpus luteum and shedding of the uterine endometrium, indicating its luteolytic activity, alpha-chlorohydrin inhibited vaginal keratinization and interrupted the sex cycle. A dioestrous leucocytic pattern of the vaginal smear is retained during medication. Decreased synthesis of RNA, protein, sialic acid and glycogen concentration in the uterus and vagina suggest possible antioestrogenic action of the compound. The antifertility action of the drug may be due to its antioestrogenic property.
D000311:Adrenal Glands / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D002728:Chlorohydrins / Q000494:pharmacology*; D003338:Corpus Luteum / Q000187:drug effects; D004717:Endometrium / Q000187:drug effects; D004965:Estrogen Antagonists / Q000494:pharmacology; D005260:Female; D005298:Fertility / Q000187:drug effects*; D009929:Organ Size / Q000187:drug effects; D006080:Ovarian Follicle / Q000187:drug effects; D010053:Ovary / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D014599:Uterus / Q000187:drug effects / Q000378:metabolism; D014621:Vagina / Q000187:drug effects / Q000378:metabolism; D000517:alpha-Chlorohydrin / Q000494:pharmacology*
D002728:Chlorohydrins; D004965:Estrogen Antagonists; D000517:alpha-Chlorohydrin