title: Proliferative effect of lithocholic acid on rat liver cell in culture.
abstract: In contrast to cholic acid, deoxycholic acid and chenodeoxycholic acid, lithocholic acid (LCA) enhances the growth of rat liver cells in culture. Enhanced proliferation of LCA-treated rat liver cells persists even 12 days after LCA was removed. These findings could suggest a mutagenic effect of LCA, or a metabolite, on rat liver cells.
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis; D008095:Lithocholic Acid / Q000494:pharmacology*; D008099:Liver / Q000166:cytology / Q000187:drug effects*; D051381:Rats
chemical_list: D001647:Bile Acids and Salts; D008095:Lithocholic Acid; D004247:DNA