Survival of red blood cells in rabbits after acute administration of unlabeled stannous pyrophosphate: Concise communication.
We investigated the possibility that acute administration of unlabeled stannous pyrophosphate may adversely affect red blood cells in the rabbit. Our method was similar to the in vivo labeling of RBCs with technetium-99m for blood-pool scanning. The investigation showed that dosages recommended in the literature produce no demonstrable difference between pre- and postdose RBC survival, which strongly suggests that the stannous content of the pharmaceutical is not harmful to red blood cells.
D000818:Animals; D004905:Erythrocyte Aging / Q000187:drug effects*; D004906:Erythrocyte Count; D005260:Female; D006400:Hematocrit; D006452:Hemoglobinometry; D008297:Male; D011122:Polyphosphates / Q000633:toxicity*; D011817:Rabbits; D012156:Reticulocytes / Q000187:drug effects; D014003:Tin Polyphosphates / Q000008:administration & dosage / Q000633:toxicity*
D011122:Polyphosphates; D014003:Tin Polyphosphates