[Effect of melatonin on mitosis of the mouse ascites hepatoma Gelstein 22A].
The action of melatonin on mitosis of the mouse ascites Gelstein 22A hepatoma has been studied in C3HA male mice with 7-day ascites. The cells of ascites hepatoma have shown the metaphase block after intraperitoneal injection of melatonin. It was found that 3 hours after administration melationin at a concentration of 200 and 100 micrograms per 1 g body weight induces an increase in the mitotic index and accumulation of mitoses at the stage of metaphase.
D000818:Animals; D008114:Liver Neoplasms, Experimental / Q000503:physiopathology*; D008297:Male; D008550:Melatonin / Q000378:metabolism*; D008677:Metaphase / Q000187:drug effects; D051379:Mice; D008809:Mice, Inbred C3H; D008938:Mitosis / Q000187:drug effects*; D008940:Mitotic Index / Q000187:drug effects
D008550:Melatonin
Vliianie melatonina na mitoticheskoe delenie kletok astitnoĭ gepatomy 22A gel'shteĭn.