Cortisol secretion following nomifensine administration in normal subjects.
The effects of the oral administration of nomifensine, which inhibits endogenous cathecolamine re-uptake, on secretion of prolactin and cortisol were investigated in 12 normal subjects. In all the volunteers, a significant decrease of prolactin levels was observed following nomifensine administration. Cortisol levels were unaffected by this pharmacological treatment. The role of hypothalamic dopaminergic inhibitory system on ACTH-cortisol axis is discussed.
D000328:Adult; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000378:metabolism*; D007546:Isoquinolines / Q000494:pharmacology*; D008297:Male; D009627:Nomifensine / Q000494:pharmacology*; D011388:Prolactin / Q000097:blood
D007546:Isoquinolines; D009627:Nomifensine; D011388:Prolactin; D006854:Hydrocortisone