Transcatheter arterial embolization of experimental hepatic tumours in the rat.
After transcatheter arterial embolization with Spongostan (99.3% gelatin-similar to gelfoam) in a group of rats with experimental hepatic tumours, the angiographic and microscopic findings were compared with those in a group of rats with non-embolized liver tumours. Partial recanalization of the hepatic artery was demonstrated already after 2 to 6 days. Reduced vascularization of tumours could be demonstrated after embolization and in a few animals even decrease in tumour size. Microscopy revealed a significantly greater extent of tumour necrosis in embolized tumours of large size. Necrosis of normal liver tissue was found to a varying degree in the embolized rats, while no ischemic injury was evident in livers of most non-embolized animals.
D000818:Animals; D002445:Celiac Artery / Q000000981:diagnostic imaging; D004621:Embolization, Therapeutic; D005780:Gelatin; D006490:Hemostatics; D006499:Hepatic Artery / Q000000981:diagnostic imaging; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging / Q000628:therapy*; D009336:Necrosis; D009374:Neoplasms, Experimental / Q000628:therapy; D011859:Radiography; D051381:Rats; D011919:Rats, Inbred Strains
D006490:Hemostatics; D005780:Gelatin