title: [Effect of alcohol on pancreatic exocrine secretion].
abstract: Pancreas exocrine secretion was studied in 10 patients viapancreocymine-secretin test, determining the volume of pancreatic secretion, concentration and quantity of the secreted bicarbonate and total quantity of secreted pancreas amylase and lipase. Acute effect of alcohol was studied in the same patients and two-three days after the first determination of pancreatic secretion, a second pancreocymine-secretin test was performed, with 150 ml 40 per cent alcohol being introduced into the stomach prior to pancreocymine stimulation. The results prior to and post alcohol loading were compared in each patient. A statistically significant inhibition of pancreas bicarbonate and enzime secretion developed under the effect of alcohol. The probable pathogenetic mechanisms of alcohol effect upon pancreas are discussed.
mesh_terms: D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000201:enzymology / Q000503:physiopathology; D000438:Alcohols / Q000009:adverse effects*; D002766:Cholecystokinin; D004789:Enzyme Activation / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D012633:Secretin
chemical_list: D000438:Alcohols; D012633:Secretin; D002766:Cholecystokinin
vernacular_title: Vliianie na alkokhola vurkhu pankreasnata ekzokrinna sekretsiia.