The absorption and excretion rates of a new pyrido[1,2-a] pyrimidine derivative (Chinoin 123) in rats.
The metabolism and absorption of a potential new drug, Chinoin 123, having an antiatherogenic effect, were studied in rats. Using different methods it was confirmed that the main metabolite of the drug is a free acid form, formed by ester hydrolysis. In Sartorius Resorption Model only the gastric absorption was confirmed and calculated. In vivo experiments in rats showed rather good absorption. The blood and urine concentrations of the drug were determined.
D000284:Administration, Oral; D000818:Animals; D005260:Female; D007408:Intestinal Absorption; D008297:Male; D011725:Pyridines / Q000008:administration & dosage / Q000378:metabolism; D011743:Pyrimidines / Q000008:administration & dosage / Q000378:metabolism*; D051381:Rats; D013997:Time Factors
D011725:Pyridines; D011743:Pyrimidines; C018247:chinoin 123