Cutaneous irritation in the topical application of 30 antineoplastic agents to New Zealand white rabbits.
Of 30 antineoplastic agents studied for their primary irritation potential in rabbits, 9 showed some potential for irritation. Five of these 9 agents produced a significant dermal irritation. None of the irritation observed was considered to be irreversible skin damage. The study further showed a strong correlation between irritation observed by the Draize method and acute inflammation evaluated histopathologically. There was a tendency toward increased epidermal thickness of irritated skin sites. None of the agents produced gross or microscopically visible lesions in the internal organs observed.
D000287:Administration, Topical; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000633:toxicity*; D003877:Dermatitis, Contact / Q000209:etiology; D005260:Female; D007509:Irritants; D008297:Male; D011817:Rabbits; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D013997:Time Factors
D000970:Antineoplastic Agents; D007509:Irritants