Fetal mediators of the relationships between increased pregnancy and labour blood pressure and newborn irritability.
A prospective study of primiparous English women and their newborns failed to replicate previous findings that greater irritability was related to higher maternal blood pressure during pregnancy and labour. This apparent lack of replication prompted a search for fetal variables capable of mediating the blood pressure--irritability relationships. Relative fetal growth retardation was found in newborns of women whose peak antenatal blood pressure occurred from 20 to 32 wk gestation. Prenatal growth retardation and exposure to either oxytocin-stimulated labour or higher maternal blood pressure during spontaneous labour were associated with lower intrapartum fetal heart rate. Lower heart rate, in turn, was associated with greater crying and more frequent changes of state during behavioural assessments on the first and fifth days. It is suggested that intrapartum hypoxia is an immediate antecedent of newborn irritability. The blood pressure--irritability relationships may therefore reflect the influence of growth retardation, attributable to increased pregnancy blood pressure, and higher labour blood pressure, respectively, on the ability of the fetus to withstand hypoxia and the degree of hypoxia encountered during labour.
D000773:Anesthesia, Obstetrical; D001519:Behavior; D003448:Crying; D005260:Female; D005311:Fetal Hypoxia / Q000150:complications; D005333:Fetus / Q000502:physiology*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000150:complications*; D007231:Infant, Newborn / Q000523:psychology*; D007236:Infant, Small for Gestational Age; D008614:Meperidine / Q000494:pharmacology; D007744:Obstetric Labor Complications; D010121:Oxytocin / Q000494:pharmacology; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular; D011446:Prospective Studies
D010121:Oxytocin; D008614:Meperidine