Lack of radiation protective effect of orgotein in normal and malignant mammalian cells.
The potential radiation protective effect of orgotein, a metalloprotein with superoxide dismutase activity, was investigated in L1A2 tumour cells in vitro, jejunal crypt cells and C3H mouse mammary carcinoma in vivo. No effect of orgotein, given either 2 hours before irradiation or 30 min after, was observed compared to the effect of irradiation alone. Thus, it was concluded that orgotein did not influence the primary radiation response in air in mammalian cells.
D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D005260:Female; D007583:Jejunum / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects; D008175:Lung Neoplasms / Q000532:radiotherapy; D008325:Mammary Neoplasms, Experimental / Q000532:radiotherapy; D008667:Metalloproteins / Q000494:pharmacology*; D051379:Mice; D008809:Mice, Inbred C3H; D009374:Neoplasms, Experimental / Q000532:radiotherapy; D011837:Radiation-Protective Agents
D008667:Metalloproteins; D011837:Radiation-Protective Agents; C005180:orgotein