title: Hyponatremia in myxedema: a suggested therapeutic approach.
abstract: Two patients with myxedema coma and extreme hyponatremia associated with the syndrome of inappropriate secretion of antidiuretic hormone are described. Both recovered following i.v. hypertonic saline, furosemide and thyroxine. A review of 22 cases from the literature suggests that this therapeutic approach could improve the poor prognosis in this condition.
mesh_terms: D000368:Aged; D005260:Female; D005665:Furosemide / Q000627:therapeutic use; D006801:Humans; D007010:Hyponatremia / Q000188:drug therapy / Q000209:etiology*; D007177:Inappropriate ADH Syndrome / Q000150:complications; D009230:Myxedema / Q000150:complications* / Q000188:drug therapy; D012462:Saline Solution, Hypertonic / Q000627:therapeutic use; D013974:Thyroxine / Q000627:therapeutic use
chemical_list: D012462:Saline Solution, Hypertonic; D005665:Furosemide; D013974:Thyroxine