Leukopenia-induction capacity of 6-MP metallo-purine complexes in the rat.
Six-MP and its palladium and platinum complexes of this compound were administered intraperitoneally to 28 day old Sprague-Dawley rats in dosages of 15 mg/kg, 26.85 mg/kg, respectively for 21 days. The leukopenia induction capacity of 6-MP was greater at the end of day 7 while the 6-MP-Pd complex evidenced a more drastic leukocyte reduction at the end of day 21. The platinum complex was less toxic, as demonstrated by greater weight gain, while treatment with the palladium complex resulted in approximately the same weight gain as that observed in rats treated with pure 6-MP.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002614:Chelating Agents; D007958:Leukocyte Count; D007970:Leukopenia / Q000139:chemically induced*; D015122:Mercaptopurine / Q000008:administration & dosage / Q000633:toxicity*; D010165:Palladium / Q000008:administration & dosage / Q000633:toxicity*; D010984:Platinum / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D013997:Time Factors
D002614:Chelating Agents; D010984:Platinum; D010165:Palladium; D015122:Mercaptopurine