[Tumor localization in vivo on the basis of scintigraphic detection of clostridium rods by means of 131J-labeled antibodies and F(ab')2 antibody fragments].
The authors report about investigations for localization of tumours in vivo by scintigrafic iddntification of Clostridium butyricum Jena H8 by 131I-labelled antibodies and by 131I-labelled F(ab')2-fragment antibodies in mouse transplantation-tumour UVT 15264. The application of 131I-labelled anti-clostridial-rod-antibodies in tumour bearing mice demonstrates increase of radioactivity in tumours of animals, pretreated by spores, as well as in animals without pretreatment. These appearently unspecific increases of radioactivity could not be demonstrated by application of 131I-labelled F(ab')2-fragment antibodies directed against clostridial rods, but also the specific fixation of 131I-labelled F(ab')2-fragment antibodies in tumours of mice, pretreated by clostridial spores, could not be demonstrated. The results are discussed with regard to further investigations.
D000818:Animals; D000907:Antibodies, Bacterial; D003013:Clostridium / Q000276:immunology*; D007140:Immunoglobulin Fab Fragments; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000175:diagnosis*; D011817:Rabbits; D013171:Spores, Bacterial
D000907:Antibodies, Bacterial; D007140:Immunoglobulin Fab Fragments
Untersuchungen über die Möglichkeit der Tumorlokalisation in vivo auf der Basis eines szintigrafischen Klostridienstäbchen-Nachweises mit 131J-markierten Antikörpern und F(ab')2-Antikörperfragmenten.