Lung tumors from PuO2-ZrO2 aerosol particles in Syrian hamsters.
Syrian golden hamsters were given PuO2/ZrO2 particles via inhalation and/or Pu-laden ZrO2 ceramic 10-micron diameter microspheres lodged in the capillary bed of the lung. The mean initial lung burdens ranged from 8 nCi to 143 nCi for the six experimental groups of animals. Significant numbers of primary lung tumors (5-50% per group) were induced in those animals that received inhalation exposures. Additional alpha radiation administered via Pu-laden intravenous microspheres had little or no effect on tumorigenesis or the production of non-neoplastic, degenerative changes in the respiratory tract.
D000336:Aerosols; D000818:Animals; D006224:Cricetinae; D005260:Female; D008175:Lung Neoplasms / Q000209:etiology*; D008297:Male; D008647:Mesocricetus; D008863:Microspheres; D009374:Neoplasms, Experimental / Q000209:etiology; D009381:Neoplasms, Radiation-Induced; D010087:Oxides; D011005:Plutonium / Q000008:administration & dosage / Q000009:adverse effects*; D012137:Respiratory System / Q000473:pathology / Q000528:radiation effects; D015040:Zirconium / Q000008:administration & dosage / Q000009:adverse effects*
D000336:Aerosols; D010087:Oxides; D011005:Plutonium; D015040:Zirconium