Adsorption of antineoplastic drugs to polyalkylcyanoacrylate nanoparticles and their release in calf serum.
Conditions are described for attaching anticancer drugs to polyalkylcyanoacrylate nanoparticles, a new drug delivery system for cells that exhibit endocytic uptake. They are ultrafine, metabolizable, and able to associate with various drugs in a nonspecific manner. Data are given for the in vitro degradation and for drug release from this new drug carrier system.
D000327:Adsorption; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000097:blood; D002417:Cattle; D003487:Cyanoacrylates; D003609:Dactinomycin; D008727:Methotrexate; D008863:Microspheres; D010316:Particle Size
D000970:Antineoplastic Agents; D003487:Cyanoacrylates; D003609:Dactinomycin; D008727:Methotrexate