IgG4: a possible mediator of anaphylaxis in a haemophiliac patient.
Immunological investigations have been carried out on a haemophiliac patient who had developed severe anaphylaxis to bovine factor VII administration. Results have shown that the development of anaphylaxis in this patient was associated with a sudden increase in total and specific IgG4 antibodies. The significance of this observation is discussed in relation to current evidence suggesting the involvement of IgG4 antibodies in some anaphylactic conditions.
D000707:Anaphylaxis / Q000150:complications / Q000276:immunology*; D000818:Animals; D002417:Cattle; D005169:Factor VIII / Q000009:adverse effects / Q000627:therapeutic use; D006467:Hemophilia A / Q000150:complications / Q000276:immunology* / Q000628:therapy; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D008875:Middle Aged
D007074:Immunoglobulin G; D005169:Factor VIII