title: A comparison of immune responses of broiler chickens to different methods of vaccination against Newcastle disease.
abstract: One-day-old broiler chicks from 4 groups of broiler breeder chickens were immunized by different methods of vaccination: 1) aerosol; 2) intratracheal; 3) drinking water; or 4) unvaccinated. The breeder flock from which the chicks were derived was vaccinated by one of the following methods: 1) a single injection of an oil-emulsion Newcastle disease virus (NDV) vaccine; 2) two vaccinations with oil-emulsion NDV vaccine; 3) vaccination with a live NDV vaccine; and 4) unvaccinated controls. Aerosol vaccination induced higher serologic responses than water and intratracheal vaccination, as well as giving the highest levels of protection against challenge. Mortality ranged from 20% to 66% in all eight groups of birds vaccinated intratracheally and challenged at 6 weeks of age. Results of challenge tests, in agreement with results of HI tests, further demonstrated that intratracheal vaccination at one day of age does not elicit a satisfactory immune response in birds with a maternal antibody titer of 15 or higher.
mesh_terms: D000284:Administration, Oral; D000336:Aerosols; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D000917:Antibody Formation; D002645:Chickens / Q000276:immunology*; D006385:Hemagglutination Inhibition Tests; D007267:Injections; D009522:Newcastle disease virus / Q000276:immunology*; D014132:Trachea; D014611:Vaccination / Q000379:methods / Q000662:veterinary*; D014765:Viral Vaccines / Q000008:administration & dosage; D014867:Water
chemical_list: D000336:Aerosols; D000914:Antibodies, Viral; D014765:Viral Vaccines; D014867:Water