The treatment of hypertension with propranolol and bendrofluazide.
In 101 hypertensive patients, the effects of a combination of propranolol and bendrofluazide were compared with those of each drug alone. After an introductory period with a placebo, the patients received, in a double-blind randomized trial, propranolol 80 mg twice a day, bendrofluazide 2.5 mg twice a day, or both drugs together twice daily. The combination produced significantly greater reductions in lying, standing, and post-exercise systolic and diastolic blood pressure than either drug separately. Side-effects were minimal and the combination was well accepted by patients.
D000328:Adult; D000368:Aged; D001539:Bendroflumethiazide / Q000008:administration & dosage / Q000627:therapeutic use*; D004311:Double-Blind Method; D004338:Drug Combinations; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008875:Middle Aged; D010919:Placebos; D011433:Propranolol / Q000008:administration & dosage / Q000627:therapeutic use*
D004338:Drug Combinations; D010919:Placebos; D001539:Bendroflumethiazide; D011433:Propranolol