Substance P afferents from the habenula innervate the dorsal raphe nucleus.
The lateral habenula nuclei of the diencephalon innervate the median and dorsal raphe nuclei of the brainstem. Habenula lesions lead to decreased substance P levels in the dorsal but not median raphe within 24 hours. From this data, we propose a peptidergic innervation of the dorsal raphe nucleus by the habenula nuclei.
D000344:Afferent Pathways / Q000033:anatomy & histology / Q000201:enzymology; D000818:Animals; D001933:Brain Stem / Q000033:anatomy & histology*; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D005968:Glutamate Decarboxylase / Q000378:metabolism; D008297:Male; D009410:Nerve Degeneration; D011903:Raphe Nuclei / Q000033:anatomy & histology* / Q000201:enzymology; D051381:Rats; D013373:Substance P / Q000378:metabolism*; D013788:Thalamus / Q000033:anatomy & histology* / Q000201:enzymology
D013373:Substance P; D002795:Choline O-Acetyltransferase; D005968:Glutamate Decarboxylase