A comparison of three methods for inducing labor: oral prostaglandin E2, buccal desaminooxytocin, intravenous oxytocin.
A study of labor induction in 325 patients is reported. Group I (77 patients with Bioshop's scores 0-6) and 2 (69 patients with Bishop's scores 7-12) were given 0.5 mg prostaglandin E2 every half hour (maximum 5 mg per day). Group 3 (87 patients with Bishop's scores 0-6) was givne 50 International units of buccal desaminooxytocin every half hour (maximum 500 International units per day). In Group 4 (92 patients with Bishop's scores 7-12), labor was induced by primary amniotomy and automatic oxytocin infusion by the Cardiff method. In groups 1, 2 and 3, 45 per cent, 74 per cent and 41 per cent delivered within 48 hours, while 100 per cent in group 4 delivered within 24 hours. No differences were found in either the frequency of cesarean section or the incidence of low Apgar scores. A higher, but not statistically significant frequency of vacuum extraction was found in the Cardiff group (25 per cent) than in the tablet-induced groups (15 per cent). There was, however, a significantly higheroccurrence of alterations in fetal heart rate which led to instrumental intervention to hasten delivery in the Cardiff group compared to the tablet-induced patients.
D000284:Administration, Oral; D002585:Cesarean Section; D005260:Female; D005316:Fetal Distress / Q000209:etiology; D006801:Humans; D007231:Infant, Newborn; D007263:Infusions, Parenteral; D007751:Labor, Induced / Q000009:adverse effects / Q000379:methods*; D007744:Obstetric Labor Complications; D010121:Oxytocin / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology*; D011247:Pregnancy; D011458:Prostaglandins E / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D013607:Tablets; D014620:Vacuum Extraction, Obstetrical
D011458:Prostaglandins E; D013607:Tablets; D010121:Oxytocin