Effects of dl-tranylcypromine on LD50 of pentobarbital in the rat.
The LD50 of pentobarbital has been determined in rats with or without pretreatment with dl-, d- or l-tranylcypromine (5 mg/kg, i.p.). The LD50 of pentobarbital was reduced to almost one half by d- or dl-tranylcypromine as compared with the l-isomer. It is concluded that dl-tranylcypromine enhances pentobarbital toxicity by inhibition of its metabolism.
D000818:Animals; D005260:Female; D007536:Isomerism; D007928:Lethal Dose 50; D010424:Pentobarbital / Q000037:antagonists & inhibitors / Q000633:toxicity*; D051381:Rats; D014191:Tranylcypromine / Q000494:pharmacology*
D014191:Tranylcypromine; D010424:Pentobarbital