Psychotomimetics potentiate locomotor hyperactivity induced by dopaminergic drugs.
The spontaneous locomotor activity of rats was investigated in an open-field test. Apomorphine and d,1-amphetamine caused a dose dependent increase of locomotor activity. LSD, mescaline, and DMT in low doses were ineffective, when given alone, but caused a strong potentiation of the hypermotility induced by apomorphine and d,1-amphetamine. Cyproheptadine antagonized the potentiating effect of LSD without affecting the hypermotility induced by apomorphine, indicating a causal serotonergic involvement in the potentiation effect.
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D003533:Cyproheptadine / Q000494:pharmacology; D004298:Dopamine / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D006213:Hallucinogens / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats
D006213:Hallucinogens; D003533:Cyproheptadine; D000661:Amphetamine; D001058:Apomorphine; D004298:Dopamine