title: Morphometry of myocardial apex in endurance-trained mice of different ages.
abstract: Mitochondrial volume density, surface density of the outer mitochondrial membrane, the mean number and size of mitochondria, and the mean surface density of crista membranes together with the volume densities of myofibrils and sarcoplasmic space were morphometrically analyzed in cardiac muscle of two groups of sedentary control mice aged 3 and 7 months, and in two groups of mice trained either 1 month rather intensely or 4 months moderately. Of the calculated mitochondrial variables only the surface density of the outer mitochondrial membrane differed between the older controls and the older trained animals, the density being slightly smaller in the trained group. The myofibrillar volume density of the order controls was smaller than that of the younger controls, while the sarcoplasmic volume density was larger. The latter difference, possibly a function of age, was also observed in the trained groups. The results suggest that at a certain steady state level of exercise-induced cardiac muscle hypertrophy the muscle cells of trained mice do not differ markedly in ultrastructural properties from those of sedentary controls.
mesh_terms: D000367:Age Factors; D000818:Animals; D051379:Mice; D008929:Mitochondria, Heart / Q000648:ultrastructure*; D009206:Myocardium / Q000648:ultrastructure*; D009929:Organ Size; D010806:Physical Education and Training; D010807:Physical Endurance; D013997:Time Factors