Uncoupling effect of a low homolog of unbiquinone (UQ-3) in rabbit heart mitochondria.
Short-chain ubiquinone (UQ-3) inhibits ADP-stimulated respiration (state 3) in intact rabbit heart mitochondria. This effect appears to be similar in all the three sites of oxidative phosphorylation by using different respiratory substrates. Ubiquinone-3 also immobilizes lipids into mitochondrial membranes indicating that the uncoupling effect might be a consequence of an altered physical state of membrane lipids.
D000818:Animals; D008929:Mitochondria, Heart / Q000187:drug effects* / Q000378:metabolism; D010085:Oxidative Phosphorylation / Q000187:drug effects; D011817:Rabbits; D014451:Ubiquinone / Q000494:pharmacology*; D014475:Uncoupling Agents / Q000494:pharmacology*
D014475:Uncoupling Agents; D014451:Ubiquinone