Glycine stimulates the spontaneous release of newly synthesized 3H-dopamine in rat striatal slices.
Glycine (5 X 10(-5) M) stimulated the spontaneous release of 3H-DA continuously synthesized from 3H-tyrosine in striatal slices. This effect was calcium-dependent and significantly reduced in the presence of strychnine (10(-5) M). The glycine-evoked release of 3H-DA was no longer seen in the presence of tetrodotoxin (5 X 10(-7) M).
D000818:Animals; D002118:Calcium / Q000502:physiology; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D005998:Glycine / Q000494:pharmacology*; D066298:In Vitro Techniques; D051381:Rats; D013268:Stimulation, Chemical; D013331:Strychnine / Q000494:pharmacology; D013779:Tetrodotoxin / Q000494:pharmacology; D013997:Time Factors; D014443:Tyrosine / Q000378:metabolism
D014443:Tyrosine; D013779:Tetrodotoxin; D013331:Strychnine; D002118:Calcium; D005998:Glycine; D004298:Dopamine