[Experimental model for the study of the teratogenic interaction of chemical agents and drugs (toluene and acetylsalicylic acid)].
On the 10th-13th days of pregnancy toluene (3600 mg/m3) by inhalation) and on 12th day acetylsalicylic acid (500 mg/kg of body weight per os) were administered to CFY rats and the common effect of these agents was studied. It was established that: 1. the maternal toxicity increased, i.e. increased the mortality rate, decreased the consumption of the food and the gain of weight, increased the relative weight of the liver; 2. the foetal toxicity increased, i.e. increased the mortality rate of foetuses, the rate of the loss of the body weight, the number of the anomalies of the sternum and the incidence of the supernumerary ribs. It is believed, that the non-teratogenic toluene rises the utilization of the glycine and the level of the free salicylic-acid, consequently the embryotoxic effect of the acetylsalicylic-acid. The danger of the occurrence of malformations as an effect of interaction of chemical agents and drugs taken in therapeutic doses is stressed.
D000818:Animals; D001241:Aspirin / Q000633:toxicity*; D004347:Drug Interactions; D005260:Female; D008954:Models, Biological; D011247:Pregnancy; D051381:Rats; D013723:Teratogens; D014050:Toluene / Q000633:toxicity*
D013723:Teratogens; D014050:Toluene; D001241:Aspirin
Modellkísérlet munkahelyi vegyi anyagok és gyógyszerek torzkelto interakciójának vizsgálatára (toluol és acetilszalicilsav).