[Does myocardial damage arise as a result of administration of tocolytic drugs? (author's transl)].
Fifty pregnant women admitted consecutively on account of threatened abortion or premature labour and treated with Ritodrine and Verapamil intravenously in the usual dosage were investigated with respect to creatine kinase activity and, in the event of a raised level, its isoenzyme creatine kinase--MB. Determinations were carried out before treatment and, in accordance with expected peak values in case of myocardial necrosis, after 6 and 12 hours. Three pathological values were recorded and these are discussed individually. Furthermore, statistical evaluation of the recorded values showed no significant differences.
D000033:Abortion, Threatened / Q000188:drug therapy; D000293:Adolescent; D000328:Adult; D009202:Cardiomyopathies / Q000139:chemically induced* / Q000201:enzymology / Q000473:pathology; D003402:Creatine Kinase / Q000378:metabolism; D005260:Female; D006801:Humans; D007527:Isoenzymes; D009336:Necrosis; D011247:Pregnancy; D011412:Propanolamines / Q000009:adverse effects*; D012312:Ritodrine / Q000009:adverse effects* / Q000627:therapeutic use; D014700:Verapamil / Q000009:adverse effects* / Q000627:therapeutic use
D007527:Isoenzymes; D011412:Propanolamines; D014700:Verapamil; D003402:Creatine Kinase; D012312:Ritodrine
Myokardschäden unter Tokolyse?