DNA 'lakes' in a malignant choroidal melanoma.
In a malignant choroidal melanoma, basophilic deposits were seen as globules between cells, intracellularly and in the vessel lumina. They were observed primarily in necrotic or incipient necrotic areas. A battery of histochemical methods showed these deposits to consist of DNA and possibly small amounts of RNA. By electron microscopy, their origin was evidenced to be the nuclear chromatin. Their presence in the vessel lumina suggested removal by the circulation. The resulting influence on the production of antibodies is also mentioned.
D000368:Aged; D002830:Choroid Neoplasms / Q000378:metabolism* / Q000648:ultrastructure; D004273:DNA, Neoplasm / Q000378:metabolism*; D006801:Humans; D008297:Male; D008545:Melanoma / Q000378:metabolism* / Q000648:ultrastructure; D008854:Microscopy, Electron; D012334:RNA, Neoplasm / Q000378:metabolism
D004273:DNA, Neoplasm; D012334:RNA, Neoplasm