The relationship between morphine, aspartic acid and L-asparaginase in rats.
Morphine and aspartic acid were administered separately and in combination to 80 rats divided into 8 groups. Ten and 20 min following the injections, brain, liver and kidney L-asparaginase activity was determined. Morphine decreased brain and liver L-asparaginase activity and increased that of kidney. Aspartic acid completely antagonized the effect of morphine. Additionally 500 IU/kg L-asparaginase and 5 or 10 mg/kg morphine were i.v. injected into 56 rats divided into 5 groups. L-Asparaginase, which, in turn, increased motor activity, antagonized the morphine-induced hypoactivity and analgesia. These results support our previous findings.
D000698:Analgesia; D000818:Animals; D001215:Asparaginase / Q000378:metabolism*; D001224:Aspartic Acid / Q000494:pharmacology*; D001921:Brain / Q000201:enzymology; D004347:Drug Interactions; D007668:Kidney / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D009020:Morphine / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D012684:Sensory Thresholds / Q000187:drug effects
D001224:Aspartic Acid; D009020:Morphine; D001215:Asparaginase