Gastric bile acids before and after Roux-en-Y transposition for bile reflux gastritis and in asymptomatic controls.
Eight patients with severe postgastrectomy syndromes for predominantly bile reflux gastritis were examined by quantification of bile acids in the gastric remnant before and after a standardized liquid meal. Gastroscopy with biopsy and determination of gastric acid secretion and gastric emptying were performed. Six of the patients were also studied 3 months after Roux-en-Y transposition. Controls consisted of six completely asymptomatic partially gastrectomized patients studied 4--11 years postoperatively and six healthy students without any history of gastrointestinal disease. The healthy subjects had virtually no reflux of bile acids in the fasting state or after a meal. Both the symptomatic and asymptomatic patients had reflux in the fasting state and postprandially. The reflux of bile acids was, however, significantly greater late in the fasting period and early in the postprandial period in the symptomatic patients than in those without symptoms. The Roux-en-Y transposition eliminated the bile acid reflux and the symptoms of bile reflux gastritis but did not change the gastric emptying pattern. In patients with reflux gastritis the acid disappearance in the gastric remnant was moderate and the maximal acid output was unchanged after Roux-en-Y transposition.
D000368:Aged; D001647:Bile Acids and Salts / Q000032:analysis*; D005260:Female; D005746:Gastric Emptying; D005750:Gastric Juice / Q000378:metabolism; D005753:Gastric Mucosa / Q000473:pathology; D005756:Gastritis / Q000209:etiology / Q000503:physiopathology* / Q000601:surgery; D005764:Gastroesophageal Reflux / Q000209:etiology / Q000503:physiopathology* / Q000601:surgery; D006801:Humans; D008297:Male; D008722:Methods; D008875:Middle Aged; D010418:Pentagastrin; D011178:Postgastrectomy Syndromes / Q000503:physiopathology*
D001647:Bile Acids and Salts; D010418:Pentagastrin