title: [The effect of drugs on laboratory diagnosis. The effect of ascorbic acid on selected automatic laboratory methods].
abstract: The paper presents further investigations for a critical survey on the influences of drugs on laboratory methods. In controversion to the meanings you can find in the literature that ascorbic acid is most one of the important drugs to interfere with laboratory results we couldn't see in our systematical experimental investigation such results. Only in very extremly cases it seems to be right. Selected parameters of clinical chemistry (glucose, lactic dehydrogenase, aspartal-aminotransferase, alanine aminotransferase, alkaline phosphatase, protein, albumine, creatinine, butanol extractable iodine, ferrum) show under therapeutic conditions no influences of ascorbic acid, which can lead to diagnostic or therapeutic false interpretations. Above all the often mentioned example that glucose estimations in blood (reduction methods) can disturb if ascorbic acid is present, is abstracted in an uncritical manner how our experimental results may show.
mesh_terms: D001205:Ascorbic Acid / Q000494:pharmacology* / Q000627:therapeutic use; D001331:Automation; D001786:Blood Glucose / Q000032:analysis; D001798:Blood Proteins / Q000032:analysis; D019411:Clinical Laboratory Techniques; D003139:Common Cold / Q000188:drug therapy; D004798:Enzymes / Q000097:blood; D006801:Humans; D007455:Iodine / Q000097:blood; D007501:Iron / Q000097:blood
chemical_list: D001786:Blood Glucose; D001798:Blood Proteins; D004798:Enzymes; D007455:Iodine; D007501:Iron; D001205:Ascorbic Acid
vernacular_title: Beeinflussung der Labordiagnostik durch Arzneimittel--Untersuchung des Askorbinsäureeinflusses auf ausgewählte Automatenlabormethoden.