title: Avian malaria in African black-footed penguins.
abstract: Ten captive-reared African black-footed penguins (Spheniscus demersus) from a large outdoor colony were monitored for avian malaria, using several diagnostic tests. One treatment regimen was evaluated. Thin smear blood evaluation enabled detection of seven parasitemias involving Plasmodium relictum and Plasmodium elongatum in the penguins. Leukocytosis (relative lymphocytosis) was characteristic of infected birds. Parasitemia was detected as early as 21 days prior to onset of clinical signs (depression, anorexia, regurgitation, pale mucous membranes, and respiratory distress). The single bird that died had clinical signs only a few hours prior to its death. Treatment consisted of 0.03 mg of primaquine phosphate base/kg body weight, administered orally once daily for 3 days. Oral chloroquine phosphate therapy, given simultaneously, was administered in an initial loading dose of 10 mg of chloroquine phosphate base/kg body weight, followed by doses of 5 mg/kg at 6, 18 and 24 hours after the initial chloroquine dose. This treatment regimen prevented mortality and cleared parasites from the blood. Recurrences of malaria occurred in two birds that had received this treatment.
mesh_terms: D000818:Animals; D001715:Bird Diseases / Q000188:drug therapy / Q000469:parasitology*; D001717:Birds / Q000469:parasitology*; D001772:Blood Cell Count; D002738:Chloroquine / Q000627:therapeutic use; D008289:Malaria, Avian / Q000188:drug therapy / Q000469:parasitology*; D010961:Plasmodium; D011319:Primaquine / Q000627:therapeutic use
chemical_list: D002738:Chloroquine; D011319:Primaquine