The transformation of cytoplasmic microtubules into helices and paracrystals by halothane in the foraminifer Allogromia laticollaris Arnold.
After treatment of cells of the foraminifer Allogromia laticollaris Arnold (protozoa, rhizopoda) with the volatile anesthetic halothane in concentrations of more than 1 mM no cytoplasmic microtubules are demonstrable. In place of microtubules, other tubulin polymers that are helices or paracrystalline structures, with the same ultrastructure as seen after treatment with vinca alkaloids, can be identified. Below 1 mM halothane, besides loosely arranged paracrystals, single helices, microtubules and transition stages between microtubules and helices can be seen in close juxtaposition. Reasons for the transformation of microtubules and the involvement of microtubules in narcosis are discussed.
D000818:Animals; D003460:Crystallization; D003595:Cytoplasmic Streaming / Q000187:drug effects; D056890:Eukaryota / Q000187:drug effects / Q000648:ultrastructure*; D006221:Halothane / Q000494:pharmacology*; D008870:Microtubules / Q000187:drug effects* / Q000648:ultrastructure
D006221:Halothane