Cytotaxin receptors of neutrophils: evidence that F-methionyl peptides and pepstatin share a common receptor.
Pepstatin, a chemotactic microbial pentapeptide, competes with f-Met-Leu-[3H]Phe for binding to human neutrophils. Furthermore, porcine neutrophils, which neither specifically bind nor respond chemotactically to the synthetic f-methionyl peptides, also fail to respond chemotactically to pepstatin. These results suggest that pepstatin shares a receptor on the neutrophil with f-methionyl peptides, despite their completely different amino acid compositions. The specificity of this cytotaxin receptor may therefore be broader than expected and depend on ligand characteristics distinct from primary structure.
D000818:Animals; D001665:Binding Sites; D001667:Binding, Competitive; D002630:Chemotactic Factors / Q000378:metabolism*; D002634:Chemotaxis, Leukocyte; D004151:Dipeptides / Q000378:metabolism*; D006801:Humans; D008715:Methionine / Q000031:analogs & derivatives*; D009239:N-Formylmethionine / Q000031:analogs & derivatives* / Q000378:metabolism; D009504:Neutrophils / Q000378:metabolism* / Q000502:physiology; D009842:Oligopeptides / Q000378:metabolism*; D010436:Pepstatins / Q000378:metabolism*; D013552:Swine
D002630:Chemotactic Factors; D004151:Dipeptides; D009842:Oligopeptides; D010436:Pepstatins; D009239:N-Formylmethionine; D008715:Methionine