On the metabolic detoxication of thymol in rabbit and man.
The metabolic detoxication of thymol was investigated in rabbit and man. Thymol glucuronide which the aglycone is intact, was isolated from thymol medicated rabbit urine and identified as a acetyl derivative of methyl glucuronate. The hydroxylated product of thymol, thymohydroquinone, was recognized in a small amount in thymol medicated human urine. It was presumed that thymohydroquinone is excreted as ethereal sulfuric acid conjugate in man.
D000818:Animals; D005965:Glucuronates / Q000652:urine; D006801:Humans; D006868:Hydrolysis; D006900:Hydroxylation; D008658:Inactivation, Metabolic; D011817:Rabbits; D013045:Species Specificity; D013943:Thymol / Q000378:metabolism* / Q000633:toxicity / Q000652:urine; D013997:Time Factors
D005965:Glucuronates; D013943:Thymol