Prostaglandin F2 alpha-induced response of the bovine ovary, oviduct (uterine tube), and uterus.
Tissue strips from the ovary, (uterine tube), and oviduct, and uterus of pregnant and nonpregnant cows were tested for their contractile response to prostaglandin F2 alpha (PGF2 alpha). When 2.1 x 10(-6)M PGF2 alpha was added to the uterine strips, tension of tissues from pregnant cows increased sharply; however, tension in tissues from nonpregnant cows only increased moderately. Similar concentrations failed to elicit any response from oviductal tissues of either group. Unlike the uterus and the oviduct, the ovaries contracted slowly and irregularly. They responded with varying degrees of stimulation; ovaries from pregnant cows with brief and mild stimulation and ovaries from nonpregnant cows with slower and relatively stronger stimulation. Results indicate that the bovine ovary contracts rhythmically and that its sensitivity to PGF2 alpha decreases during pregnancy in contrast to the bovine uterus which becomes increasingly sensitive during pregnancy.
D000818:Animals; D002417:Cattle; D002418:Cattle Diseases; D005187:Fallopian Tubes / Q000187:drug effects; D005260:Female; D010053:Ovary / Q000187:drug effects; D011247:Pregnancy; D011248:Pregnancy Complications / Q000662:veterinary; D011270:Pregnancy, Animal / Q000187:drug effects*; D011461:Prostaglandins F, Synthetic / Q000494:pharmacology*; D014590:Uterine Contraction / Q000187:drug effects*; D014599:Uterus / Q000187:drug effects
D011461:Prostaglandins F, Synthetic