title: [Principles of therapeutic trials (author's transl)].
abstract: Therapeutic trials aim at comparing the effectiveness of two therapeutic attitudes. The problems involved are considered: comparability requirements of the groups, assured by randomization, which raises ethical questions. The need of a "sufficient" number of subjects, often imposing cooperative trials, is then discussed. Finally, it is necessary to define the disease and patients, the therapeutic possibilities, and judgement criteria.
mesh_terms: D002986:Clinical Trials as Topic / Q000379:methods*; D004992:Ethics, Medical; D006801:Humans; D011897:Random Allocation
vernacular_title: Principes de l'essai thérapeutique.