Observations on some properties of a long-acting preparation of propranolol.
1. The effects of 160 mg of propranolol and 160 mg of a long-acting (LA) formulation of propranolol were studied in healthy subjects. 2. Both drugs reduced an exercise tachycardia but the peak was less and the 24 h effect greater after long-acting propranolol than after propranolol. 3. These differences were maintained on repeated dosing for 8 days. 4. In contrast to single doses of 400 mg of sotalol, 160 mg of oxprenolol and 160 mg of slow-release oxprenolol, the peak effect of long-acting propranolol was less and that at 24 h was greater.
D000328:Adult; D003692:Delayed-Action Preparations; D006207:Half-Life; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D010096:Oxprenolol / Q000097:blood / Q000494:pharmacology; D005082:Physical Exertion; D011433:Propranolol / Q000097:blood; D013015:Sotalol / Q000097:blood / Q000494:pharmacology
D003692:Delayed-Action Preparations; D010096:Oxprenolol; D011433:Propranolol; D013015:Sotalol