[Circulating somatomedin activity and growth hormone secretion. Changes during late diagnosed celiac disease and effects of treatment].
Sixteen children, aged 5-19 years with late diagnosed coeliac disease who presented with significant growth delay were studied. Plasma somatomedin was decreased in all patients (mean 0.28 +/- 0.1) but the circulating growth hormone levels were normal in 12 patients. No inhibitory activity could be detected. Somatomedin activity was partially corrected in six patients who were re-examined after 3 months on a gluten free diet. This suggests that low somatomedin levels may be the result of the nutritional abnormalities during the active phase of the disease.
D000293:Adolescent; D000328:Adult; D002446:Celiac Disease / Q000097:blood* / Q000150:complications / Q000178:diet therapy; D002648:Child; D005260:Female; D005983:Glutens / Q000008:administration & dosage; D006130:Growth Disorders / Q000209:etiology; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D008297:Male; D013002:Somatomedins / Q000097:blood*
D013002:Somatomedins; D005983:Glutens; D013006:Growth Hormone
Activité somatomédine circulante et sécretion d'hormone de croissance. Modifications au cours de la maladie coeliaque à révélation tardive et effets du traitement.