In vitro effect of D-isoascorbic acid and betaine hydrate alone and in combination on normal and malignant cells.
D-Isoascorbic acid, an isomer of vitamin C, and betaine hydrate (quaternary amine) were found to inhibit mitoses of sarcoma 37, Ehrlich carcinoma, and L1210 leukemia cells in vitro. However, the combined effect of these compounds produced a greater inhibitory activity than when either was administered individually.
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D001622:Betaine / Q000494:pharmacology*; D002286:Carcinoma, Ehrlich Tumor / Q000473:pathology; D002460:Cell Line; D004359:Drug Therapy, Combination; D007939:Leukemia L1210 / Q000473:pathology; D051379:Mice; D008938:Mitosis / Q000187:drug effects*; D009374:Neoplasms, Experimental / Q000473:pathology*; D012511:Sarcoma 37 / Q000473:pathology
D001622:Betaine; D001205:Ascorbic Acid