Haloperidol-induced changes in the regional cerebral pharmacokinetics of apomorphine.
Haloperidol did not change significantly the rate of penetration of apomorphine to three investigated structures of the rat brain: striatum, limbic forebrain and cerebellum. It depressed, however, significantly the accumulation of apomorphine in the striatum and limbic forebrain; in the cerebellum, in which the accumulation of apomorphine was very low, haloperidol did not change it. In haloperidol-pretreated rats the pattern of elimination of apomorphine from the striatum changed, revealing the presence of two compartments; this was not observed in the limbic forebrain, from which the elimination was linear, both in the presence and absence of haloperidol.
D000818:Animals; D001058:Apomorphine / Q000378:metabolism*; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002531:Cerebellum / Q000378:metabolism; D003342:Corpus Striatum / Q000378:metabolism; D006207:Half-Life; D006220:Haloperidol / Q000494:pharmacology*; D007700:Kinetics; D008032:Limbic System / Q000378:metabolism; D008297:Male; D051381:Rats; D013997:Time Factors
D006220:Haloperidol; D001058:Apomorphine