Antithrombin III in uremia.
Antithrombin III (AT-III) was measured immunologically in 20 uremic patients on maintenance hemodialysis and in 10 non-dialysed uremic patients. The dialysed patients had slightly elevated AT-III levels. The non-dialysed patients had significantly elevated AT-III levels. A negative correlation was found between AT-III and serum creatinine and between AT-III and serum albumin. AT-III did not correlate to the heparin amount required for hemodialysis. A negative correlation was found between the heparin requirement and serum albumin. It is suggested, that serum albumin might facilitate the action of AT-III and heparin. It is also suggested, that AT-III levels may be high in active renal disease, decreasing as uremia advances.
D000328:Adult; D000368:Aged; D000990:Antithrombin III / Q000032:analysis*; D001774:Blood Chemical Analysis; D001777:Blood Coagulation / Q000187:drug effects; D003404:Creatinine / Q000097:blood; D005260:Female; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D006435:Renal Dialysis; D012709:Serum Albumin / Q000032:analysis; D014511:Uremia / Q000097:blood*
D012709:Serum Albumin; D000990:Antithrombin III; D006493:Heparin; D003404:Creatinine