Stimulation of reparative processes in the damaged myocardium by the RNA preparations.
RNA preparations were used as stimulants of reparative processes in rat myocardium damaged by diathermocoagulation. Administration of RNA accelerated the proteosynthesis in the zone of the lesion, as indicated by the intensity of incorporation of 14C-labelled amino-acids. Morphological examinations of the myocardium revealed increased synthetic activity in fibroblasts, proliferation of fibroblasts, and accelerated scar healing. The results prove the stimulating effect of RNA preparations on reparative processes in the damaged myocardium.
D000818:Animals; D005260:Female; D006321:Heart / Q000187:drug effects / Q000502:physiology*; D009206:Myocardium / Q000473:pathology; D009336:Necrosis / Q000188:drug therapy / Q000473:pathology; D012313:RNA / Q000494:pharmacology*; D051381:Rats; D012038:Regeneration / Q000187:drug effects*
D012313:RNA