Synthesis of tritium-labeled N-acetyl PGE2 carboxamide (CP-27,987).
The preparation of N-acetyl PGE2 carboxamide (CP-27,987) regioselectively labeled at C-18 and C-19 with tritium is described. The overall radiochemical yield was 8.0% at a specific activity of 0.49 Ci/mmole. The synthesis employed is applicable to the preparation of tritium labeled natural prostaglandins and a variety of analogs.
D055598:Chemical Phenomena; D002621:Chemistry; D015232:Dinoprostone / Q000031:analogs & derivatives*; D007553:Isotope Labeling; D011459:Prostaglandins E, Synthetic / Q000138:chemical synthesis*; D014316:Tritium
D011459:Prostaglandins E, Synthetic; D014316:Tritium; C024543:N-acetylprostaglandin E2 carboxamide; D015232:Dinoprostone