An examination of the role of vitamin E in glucose-6-phosphate dehydrogenase deficiency.
The effect of vitamin E on erythrocyte glutathione stability was studied both in vitro and in vivo on subjects with glucose-6-phosphate dehydrogenase deficiency. The results suggest that lipid membrane peroxidation in glucose-6-phosphate dehydrogenase deficient erythrocytes, which has been postulated to occur under conditions of oxidative stress, does not result in significant depletion of erythrocyte reduced glutathione pools. Vitamin E supplementation in these individuals was shown to have little or no effect on the response of their erythrocytes to oxidative stress.
D004912:Erythrocytes / Q000187:drug effects; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000097:blood* / Q000188:drug therapy; D005978:Glutathione / Q000097:blood*; D006801:Humans; D014810:Vitamin E / Q000097:blood / Q000494:pharmacology* / Q000627:therapeutic use
D014810:Vitamin E; D005978:Glutathione