[Coagulation and fibrinolysis proteins in nephrotic syndromes in children].
The main coagulation and fibrinolysis proteins have been studied in 22 children with nephrotic syndrome. Some anomalies such as the increase of fibrinogen and of Factors II, V, VII + X concentrations and the decrease of antithrombin III concentration could induce an hypercoagulability. Other anomalies such as the high alpha 2 macroglobulin concentration and the frequently low plasminogen concentrations could induce a decrease of the plasma fibrinolytic activity. The consequences of the low alpha 1 antitrypsin levels are probably less important. The fast alpha 2 antiplasmin levels have been found variable in the different patients. Practically, it appears that most children with plasma albumin levels less than 15-17 g/l have antithrombin III levels less than 23 mg/dl (70% of normal), which appears to result in a high risk of thrombosis (11).
D000293:Adolescent; D000933:Antifibrinolytic Agents / Q000097:blood; D000990:Antithrombin III / Q000032:analysis; D001777:Blood Coagulation; D001798:Blood Proteins / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D005340:Fibrinogen / Q000032:analysis; D005342:Fibrinolysis; D006801:Humans; D007223:Infant; D009404:Nephrotic Syndrome / Q000097:blood*; D010958:Plasminogen / Q000032:analysis; D011516:Prothrombin / Q000032:analysis; D012306:Risk; D012709:Serum Albumin / Q000032:analysis; D013924:Thrombophlebitis / Q000097:blood
D000933:Antifibrinolytic Agents; D001798:Blood Proteins; D012709:Serum Albumin; D000990:Antithrombin III; D011516:Prothrombin; D005340:Fibrinogen; D010958:Plasminogen
Etude des protéines de la coagulation et de la fibrinolyse au cours des syndromes néphrotiques de l'enfant.