title: Histopathology, histochemistry and acetylcholinesterase activity after repetitive administration of fluostigmine to albino rat.
abstract: Histopathological, histochemical and biochemical investigations were performed on the brain, sciatic nerve, skeletal muscle, heart, liver and kidney of rats which were given 5% of LD50 dose of DFP for 10 days. A decrease in AChE activity, degeneration of neurons and necrotic changes in the nuclei of hypothalamus, degeneration of myelin sheaths in sciatic nerve, a decrease in succinic dehydrogenase activity in the myocardium, and a minimal decrease of acid phosphatase activity (AcPh) in the liver were found. The biochemical determination of AChE level indicated about 30% AChE activity in erythrocytes and tibialis muscle, and 40% in the brain 1 hr after the last dose of the inhibitor and 80% and 50% respectively on the 7th day after poisoning in relation to normal values.
mesh_terms: D000110:Acetylcholinesterase / Q000097:blood / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology; D003964:Diaphragm / Q000201:enzymology; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D006651:Histocytochemistry; D007531:Isoflurophate / Q000633:toxicity*; D007668:Kidney / Q000473:pathology; D008099:Liver / Q000473:pathology; D009132:Muscles / Q000201:enzymology / Q000473:pathology; D009206:Myocardium / Q000201:enzymology; D010286:Paraventricular Hypothalamic Nucleus / Q000473:pathology; D051381:Rats; D012584:Sciatic Nerve / Q000473:pathology; D013385:Succinate Dehydrogenase / Q000378:metabolism; D013495:Supraoptic Nucleus / Q000473:pathology
chemical_list: D007531:Isoflurophate; D013385:Succinate Dehydrogenase; D000110:Acetylcholinesterase