title: Peptide--neurotransmitter interactions influencing ethanol tolerance.
abstract: Chronic exposure of mice to ethanol leads to the development of functional tolerance to the hypothermic and sedative effects of this drug. Treatment of the animals with the mammalian antidiuretic hormone, arginine vasopressin, results in a prolonged duration of such tolerance, in comparison to animals exposed to ethanol but not to the hormone. Another neurohypophyseal hormone, oxytocin, at an equimolar dose, is ineffective in maintaining tolerance. The centrally mediated  effects of arginine vasopressin on memory processes may be related to the hormone-induced prolongation of ethanol tolerance.
mesh_terms: D000818:Animals; D001127:Arginine Vasopressin / Q000502:physiology*; D001831:Body Temperature / Q000187:drug effects; D004361:Drug Tolerance; D000431:Ethanol / Q000494:pharmacology*; D008297:Male; D008568:Memory / Q000187:drug effects; D051379:Mice; D010121:Oxytocin / Q000494:pharmacology
chemical_list: D001127:Arginine Vasopressin; D000431:Ethanol; D010121:Oxytocin