Suppressive factor against macrophage phagocytosis produced by cultured sarcoma-180 cells.
A soluble factor which suppresses phagocytic ability of macrophages against Staphylococcus aureus, as well as latex particles, was found in the culture supernatant of sarcoma-180 cells. This factor was stable to heating at 56 degrees for 30 min and had a molecular weight of more than 10,000. Supernatant from normal spleen cell culture also showed some antiphagocytic activity but it was considerably lower than that of sarcoma-180 cell culture.
D000818:Animals; D002478:Cells, Cultured; D008264:Macrophages / Q000502:physiology*; D051379:Mice; D008970:Molecular Weight; D010587:Phagocytosis; D012510:Sarcoma 180 / Q000378:metabolism*; D013211:Staphylococcus aureus