title: [Photoprotection by psoralen-UVA therapy: experimental and clinical results (author's transl)].
abstract: Studies on minimum erythema doses, histological investigations and quantitative determination of DNA repair synthesis of epidermal cells revealed that a tan induced by the oral administration of 8-methoxy-psoralen (8-MOP) and subsequent UVA irradiation gives protection from the erythemogenic effects of sunlight, diminishes UVA-induced cellular injury in the epidermis and, possibly, also shields DNA from incident UV radiation. In a study of 14 patients with severe polymorphous light dermatosis the 8-MOP-UVA induced tan proved to be a clinically effective sunscreen. The uncontrolled use of this method for UV protection of normal individual is, however, not recommended.
mesh_terms: D004260:DNA Repair / Q000187:drug effects; D005260:Female; D006801:Humans; D008027:Light; D008297:Male; D008730:Methoxsalen / Q000627:therapeutic use*; D010787:Photosensitivity Disorders / Q000517:prevention & control*; D011835:Radiation Protection; D012867:Skin / Q000473:pathology; D014466:Ultraviolet Rays
chemical_list: D008730:Methoxsalen
vernacular_title: Lichtschutz durch Psoralen-UVA-Behandlung Experimentelle und klinische Ergebnisse.