Responsiveness and high-energy phosphate metabolism of isolated dog coronary arteries.
The relationship between responsiveness and high-energy phosphate metabolism was observed in isolated dog coronary arterial strips before and after equilibration, under aerobic conditions. The strips responded slowly to potassium, norepinephrine, isoproterenol and 5-hydroxytryptamine before being equilibrated but did respond quickly to these drugs after being equilibrated for 1 hour under aerobic conditions. The contents of ATP, creatine phosphate (CP) and lactate were not significantly altered before and after equilibration for 1 hr. It is proposed that, before being equilibrated under aerobic conditions, coronary arteries may be unable to utilize ATP and CP due to injury of contractile or relaxant mechanisms resulting in a weak vascular responsiveness.
D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D003331:Coronary Vessels / Q000187:drug effects / Q000378:metabolism; D004285:Dogs; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000378:metabolism; D009638:Norepinephrine / Q000494:pharmacology; D010100:Oxygen; D010725:Phosphocreatine / Q000378:metabolism*; D011188:Potassium / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology
D010725:Phosphocreatine; D012701:Serotonin; D000255:Adenosine Triphosphate; D011188:Potassium; D010100:Oxygen; D009638:Norepinephrine