title: Investigation of Haemonchus contortus infections in sheep. Comparison of irradiated larvae and transfer factor treatment.
abstract: A comparison is made between the resistance conferred to Haemonchus contortus challenge by irradiated larval treatment and transfer factor (TF) treatment in four-month-old lambs and seven-month-old lambs. As in previous investigations the irradiated larval treatment failed to confer resistance to the four-month-old lambs challenged with 10,000 third stage larvae while similar irradiated larval treatment in seven-month-old lambs reduced the worm burdens by 40 per cent compared to controls. The TF treatment produced a 34 per cent reduction in the challenge infection in the four-month-old lambs and a 45 per cent reduction in the seven-month-old lambs compared to the control lambs. It is concluded that TF activity operates independently of immune competence.
mesh_terms: D000818:Animals; D006188:Haemonchiasis / Q000517:prevention & control / Q000662:veterinary*; D006189:Haemonchus / Q000276:immunology / Q000528:radiation effects*; D007814:Larva; D012756:Sheep; D012757:Sheep Diseases / Q000517:prevention & control*; D014165:Transfer Factor / Q000276:immunology*; D014251:Trichostrongyloidea / Q000528:radiation effects*; D014252:Trichostrongyloidiasis / Q000662:veterinary*
chemical_list: D014165:Transfer Factor