title: [The effects of halothane-, nitroprusside- and trimethaphan-induced hypotension on cerebral blood flow and intracranial pressure (author's transl)].
abstract: Arterial hypotension to about 50 mm Hg mean pressure was induced in anaesthetized and artificially ventilated dogs by halothane, nitroprusside, and trimethaphan to study their effects on cerebral blood flow and intracranial pressure during hypotension. During nitroprusside induced hypotension there was a 32% increase in cerebral blood flow above control and a marked decrease in cerebral arteriovenous oxygen content difference indicating luxury perfusion of the brain. Cerebral blood flow remained high even 30 min after termination of hypotension. During halothane and trimethaphan hypotension cerebral blood flow remained unchanged. In all groups epidural pressure did not change substantially during hypotension but increased during recovery from nitroprusside hypotension by a maximum of 72% above control. It is concluded that during and after nitroprusside hypotension loss of cerebral autoregulation occurs which may result in a marked rise in intracranial pressure. Special vulnerability seems to exist shortly after termination of induced hypotension when arterial pressure begins to rise and brain perfusion follows a pressure-flow relationship.
mesh_terms: D000818:Animals; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004285:Dogs; D005292:Ferricyanides / Q000494:pharmacology*; D006221:Halothane / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects; D007023:Hypotension, Controlled / Q000379:methods*; D007427:Intracranial Pressure / Q000187:drug effects*; D009599:Nitroprusside / Q000494:pharmacology*; D013997:Time Factors; D014294:Trimethaphan / Q000494:pharmacology*
chemical_list: D005292:Ferricyanides; D009599:Nitroprusside; D014294:Trimethaphan; D006221:Halothane
vernacular_title: Die Auswirkungen einer kontrollierten Hypotension mit Nitroprussid-Natrium, Trimethaphan und Halothan auf Hirndurchblutung und intracraniellen Druck.