Two apparently healthy Japanese individuals of type MkMk have erythrocytes which lack both the blood group MN and Ss-active sialoglycoproteins.
A Japanese blood donor (H. T.) and his brother (M. S.) are the first homozygous MkMk individuals described; their red cells lack, as expected, known antigens of the MNSs blood group system and also have no demonstrable MN-active and Ss-active glycoproteins. Both MkMk individuals have a naturally occurring atypical antibody in their serum. The antibody in the serum of H. T. is inhibited by MNSs-active glycoprotein preparations from normal erythrocytes.
D000818:Animals; D000906:Antibodies / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D004591:Electrophoresis, Polyacrylamide Gel; D004912:Erythrocytes / Q000276:immunology; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D007564:Japan; D008951:MNSs Blood-Group System / Q000276:immunology*; D010375:Pedigree; D011817:Rabbits; D012795:Sialoglycoproteins / Q000276:immunology*
D000906:Antibodies; D008951:MNSs Blood-Group System; D012795:Sialoglycoproteins