Preparation and biochemical properties of PGH3.
PGH3 was biosynthesised from all-cis-5,8,11,14,17-eicosapentaenoic acid (20:5 omega 3) by an acetone-pentane powder of ram seminal vesicles and its structure was confirmed by GLC-MS after its reduction to PGF 3 alpha. PGH3 was transformed by horse platelet microsomes to TXB3, and by aortic microsomes to delta 17-6-keto-PGF 1 alpha. The structures of these compounds were confirmed by GLC-MS.
D000818:Animals; D001011:Aorta / Q000378:metabolism; D001792:Blood Platelets / Q000378:metabolism; D004537:Eicosanoic Acids; D005231:Fatty Acids, Unsaturated; D008401:Gas Chromatography-Mass Spectrometry; D006736:Horses; D008297:Male; D008861:Microsomes / Q000378:metabolism; D011449:Prostaglandin Endoperoxides / Q000096:biosynthesis*; D011460:Prostaglandins F / Q000378:metabolism; D011463:Prostaglandins H / Q000096:biosynthesis* / Q000378:metabolism; D012669:Seminal Vesicles / Q000166:cytology / Q000378:metabolism; D012756:Sheep; D013931:Thromboxanes / Q000378:metabolism
D004537:Eicosanoic Acids; D005231:Fatty Acids, Unsaturated; D011449:Prostaglandin Endoperoxides; D011460:Prostaglandins F; D011463:Prostaglandins H; D013931:Thromboxanes