title: Problems with activated charcoal and alumina as sorbents for medical use.
abstract: Although activated charcoal and alumina have been used extensively as sorbents in uremic patients, the following problems remain to be solved: 1) elution of SO4--from activated charcoal which does not adsorb it; 2) production of methylguanidine from creatinine on the surface of activated charcoal; 3) production of lipoperoxide from fatty acids by chemical reaction of activated charcoal; 4) adsorption of Ca++ and Mg++ when alumina adsorbs inorganic phosphate. These problems are studied in vitro and clinically.
mesh_terms: D000327:Adsorption; D000535:Aluminum; D000537:Aluminum Oxide; D001806:Blood Urea Nitrogen; D002118:Calcium; D002606:Charcoal; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003404:Creatinine; D006801:Humans; D008054:Lipid Peroxides; D008760:Methylguanidine; D006435:Renal Dialysis; D013431:Sulfates; D014508:Urea
chemical_list: D008054:Lipid Peroxides; D013431:Sulfates; D002606:Charcoal; D008760:Methylguanidine; D014508:Urea; D003404:Creatinine; D000535:Aluminum; D000537:Aluminum Oxide; D002118:Calcium