Influence of the plasticiser di-2-ethylhexyl-phthalate on drug metabolising enzymes in the liver of uraemic rats.
After bilateral or subtotal nephrectomy male rats were given intraperitoneal injections of the plasticiser di-2-ethylhexylphthalate (DEHP) at differing time intervals in doses that do not affect the liver of normal rats. 200mg DEHP/100g body weight had no influence on the parameters measured. After administering 7 x 200mg/100g body weight for 14 days, liver weight and in vitro activity of the mixed function oxidation system increased significantly. In addition, the hexobarbital sleeping time decreased, indicating a stimulation of the activity of drug metabolising enzymes in vivo. Similar results were obtained after the administration of 56 x 50mg DEHP/100g body weight for 19 weeks. It is concluded that uraemic rats are more susceptible to inducing effects, but that the DEHP toxicity is of little importance.
D000818:Animals; D004051:Diethylhexyl Phthalate / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004950:Esterases / Q000378:metabolism; D006591:Hexobarbital / Q000494:pharmacology; D008099:Liver / Q000033:anatomy & histology / Q000201:enzymology*; D008297:Male; D009929:Organ Size; D010084:Oxidation-Reduction; D010088:Oxidoreductases / Q000378:metabolism; D010795:Phthalic Acids / Q000494:pharmacology*; D051381:Rats; D014511:Uremia / Q000378:metabolism*
D010795:Phthalic Acids; D006591:Hexobarbital; D004051:Diethylhexyl Phthalate; D010088:Oxidoreductases; D004950:Esterases