title: [High-pressure liquid chromatographic determination of benfurodil hemisuccinate in blood and urine (author's transl)].
abstract: A sensitive and reliable method for quantitative determination of benfurodil hemisuccinate and benfurodil in plasma by high-pressure liquid chromatography on a Zorbax SIL column with a mean particle size of 7 micrometer and UV detection at 254 nm is described. Benfurodil hemisuccinate is stable in plasma but not in aqueous solutions. This is explained by its great fixation to plasma proteins which has been shown by equilibrium dialysis.
mesh_terms: D001572:Benzofurans / Q000097:blood* / Q000652:urine; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D003956:Dialysis; D006801:Humans; D013056:Spectrophotometry, Ultraviolet; D013997:Time Factors
chemical_list: D001572:Benzofurans; C000124:benfurodil
vernacular_title: Dosage de l'hémisuccinate de benfurodil dans le sang et l'urine par chromatographie en phase liquide haute pression.