title: [Changes in the urinary bladders of rats during experimental carcinogenesis].
abstract: Rats receiving with drinking water a 0.4% solution of a-butyl-N-butanol-nitrosamine developed by 4 months transitional cell papillomas and by 10 months transitional cell carcinomas in their urinary bladders. Histochemical examinations of the transitional epithelium in the course of malignization revealed a gradual decrease in the activity of nonspecific alkaline phosphatase and increased activity of monoaminoxidase and beta-glucuronidase. A significantly increased activity of nonspecific acid phosphatase was observed in areas of squamous cell metaplasia.
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D002085:Butylhydroxybutylnitrosamine; D002295:Carcinoma, Transitional Cell / Q000139:chemically induced* / Q000201:enzymology; D005260:Female; D005966:Glucuronidase / Q000378:metabolism; D006965:Hyperplasia; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism; D010088:Oxidoreductases / Q000378:metabolism; D010212:Papilloma / Q000139:chemically induced* / Q000201:enzymology / Q000473:pathology; D051381:Rats; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced* / Q000201:enzymology / Q000473:pathology
chemical_list: D002085:Butylhydroxybutylnitrosamine; D010088:Oxidoreductases; D008995:Monoamine Oxidase; D000469:Alkaline Phosphatase; D005966:Glucuronidase
vernacular_title: Izmeneniia v mochevom puzyre krys pri éksperimental'nom kantserogeneze.