title: [Influenza virus neuraminidase and its role in anti-influenzal immunity].
abstract: The direct relationship between immunogenicity of H3N2 formolvaccine and neuraminidase activity was established. A single intranasal immunization of mice with the vaccine having a titer of hemagglutinin 1:20,000-1:40,000 in 0.5 ml with active neuraminidase increased the resistance of the animals to the challenge with mouse-adapted influenza A/USSR/053/74 (H3N2) virus almost 5-fold. A vaccine with the same hemagglutinin titer but with neuraminidase inactivated by physico-chemical factors or blocked by specific antibody exerted a protective effect 2.5-3 fold weaker than the vaccine with the active enzyme.
mesh_terms: D000818:Animals; D002642:Chick Embryo; D007109:Immunity; D007114:Immunization; D009980:Influenza A virus / Q000201:enzymology / Q000276:immunology*; D007252:Influenza Vaccines / Q000008:administration & dosage; D008297:Male; D051379:Mice; D009439:Neuraminidase / Q000276:immunology*; D009976:Orthomyxoviridae Infections / Q000276:immunology; D014613:Vaccines, Attenuated / Q000008:administration & dosage
chemical_list: D007252:Influenza Vaccines; D014613:Vaccines, Attenuated; D009439:Neuraminidase
vernacular_title: Neĭraminidaza virusa grippa i ee rol' v protivogrippoznom immunitete.