Plasma glucagon responses to insulin-induced hypoglycaemia and arginine in normal and alloxan diabetic rats.
A decreased plasma glucagon response to insulin-induced hypoglycaemia was found in the normoglucagonaemic alloxan diabetic rat. 0.021-0.240 ng/ml was accepted as the range of normoglucagonaemia. The reduction of the glucagon response was not due to destruction of the alpha 2-cells by alloxan, since a normal response to arginine could  be demonstrated. The decreased glucagon response to hypoglycaemia in the insulin deficient normoglucagonaemic alloxan diabetic rat suggests that this alpha 2-cell dysfunction may be caused by insulin lack.
D000496:Alloxan; D000818:Animals; D001120:Arginine / Q000494:pharmacology*; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000097:blood*; D005934:Glucagon / Q000097:blood*; D007003:Hypoglycemia / Q000139:chemically induced*; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D051381:Rats
D001786:Blood Glucose; D007328:Insulin; D000496:Alloxan; D005934:Glucagon; D001120:Arginine