A presynaptic action of dopamine on globus pallidus afferents to substantia nigra in the rat.
Dopamine applied iontophoretically onto substantia nigra and adjacent reticular formation units, changed the pattern of response evoked in these cells by stimulation of the globus pallidus. This change was reversible and was sensitive to iontophoretically applied dopamine. It is proposed that this effect is brought about by an interaction of dopamine with dopamine receptors located on afferent fibres coming from the globus pallidus.
D000109:Acetylcholine / Q000494:pharmacology; D000344:Afferent Pathways / Q000187:drug effects; D000818:Animals; D004298:Dopamine / Q000494:pharmacology*; D004558:Electric Stimulation; D005917:Globus Pallidus / Q000187:drug effects* / Q000502:physiology; D008297:Male; D051381:Rats; D012154:Reticular Formation / Q000187:drug effects; D013378:Substantia Nigra / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D005680:gamma-Aminobutyric Acid; D000109:Acetylcholine; D004298:Dopamine