Human erythropoiesis in diffusion chambers.
The diffusion chamber technique has been modified in order to stimulate human erythropoiesis in addition to granulo- and monocytopoiesis. The chamber recipient mice were subjected to a combination of 750 rad irradiation and long-term non-interrupted hypoxia (0.5 atm) without chamber retransplantation. 7 d after implantation erythroid cells started to increase, reaching a maximum of up to 70% of the nucleated cells on day 12.
D000818:Animals; D001854:Bone Marrow Cells; D002452:Cell Count; D002478:Cells, Cultured; D004900:Erythroblasts / Q000166:cytology; D004920:Erythropoiesis / Q000528:radiation effects; D005260:Female; D006098:Granulocytes / Q000166:cytology; D006801:Humans; D000860:Hypoxia; D008264:Macrophages / Q000166:cytology; D051379:Mice