Human thymus cells: effects of glucocorticoids in vitro.
The level of glucocorticoid receptors and the effects of dexamethasone on 3H-Uridine and 3H-Thymidine incorporation have been determined in normal human thymus cells. Under the experimental conditions employed human thymocytes appear more steroid-sensitive in vitro than human circulating lymphocytes.
D000818:Animals; D001665:Binding Sites; D002675:Child, Preschool; D004247:DNA / Q000096:biosynthesis; D003907:Dexamethasone / Q000378:metabolism; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000503:physiopathology; D007223:Infant; D008297:Male; D051379:Mice; D012313:RNA / Q000096:biosynthesis; D011965:Receptors, Glucocorticoid / Q000502:physiology*; D011987:Receptors, Steroid / Q000502:physiology*; D013936:Thymidine / Q000378:metabolism; D013950:Thymus Gland / Q000166:cytology* / Q000473:pathology; D014529:Uridine / Q000378:metabolism
D011965:Receptors, Glucocorticoid; D011987:Receptors, Steroid; D012313:RNA; D003907:Dexamethasone; D004247:DNA; D013936:Thymidine; D014529:Uridine