The neuromuscular and vascular hypotheses of muscular dystrophy: a possible link via adenine nucleotides and phosphate.
A hypothesis is presented that an abnormality of nucleotide synthesis or metabolism might be a primary functional defect underlying Duchenne muscular dystrophy. One aim of this hypothesis is to demonstrate that it is possible to explain a variety of observations in dystrophy, neuromuscular and vascular, on a single hypothesis.
D000227:Adenine Nucleotides / Q000096:biosynthesis* / Q000378:metabolism; D000244:Adenosine Diphosphate / Q000627:therapeutic use; D006801:Humans; D006931:Hyperbaric Oxygenation; D009132:Muscles / Q000098:blood supply; D009136:Muscular Dystrophies / Q000209:etiology* / Q000628:therapy; D009469:Neuromuscular Junction / Q000502:physiology; D009943:Organophosphorus Compounds / Q000096:biosynthesis* / Q000378:metabolism
D000227:Adenine Nucleotides; D009943:Organophosphorus Compounds; D000244:Adenosine Diphosphate