Possible mechanism of hydrocortisone induced eosinopoenia.
Hydrocortisone (HC) injection in rabbits induced eosinopoenia (reduction in absolute eosinophil count) which could be successfully abolished by beta--adrenoceptor antagonists, a propranolol, sotalol, practolol and H 35/25 but not by alpha--adrenoceptor antagonist, phenoxybenzamine. Reserpine per se produced eosinopoenia followed by eosinophilia. However, reserpine pretreatment failed to abolish HC-induced eosinopoenia. It is suggested that the eosinopoenia is mediated through beta--adrenoceptors, which could not be differentiated into beta 1/beta 2--adrenoceptor subtypes as has been possible for other beta-adrenoceptor mediated responses.
D000818:Animals; D004804:Eosinophils / Q000187:drug effects*; D005260:Female; D006854:Hydrocortisone / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D007958:Leukocyte Count; D007970:Leukopenia / Q000097:blood / Q000139:chemically induced*; D008297:Male; D011817:Rabbits; D012110:Reserpine / Q000494:pharmacology; D013565:Sympatholytics / Q000494:pharmacology; D013997:Time Factors
D013565:Sympatholytics; D012110:Reserpine; D006854:Hydrocortisone