Divalent cation-phospholipid complexes and tumor growth inhibition.
Growth inhibition of DS sarcomas provoked by calcitonin treatment is accompanied by an increase of calcium and magnesium in the phospholipid fraction. Changes in tumor cell membrane characteristics reflected in ionic or molecular transport modifications seem to be involved in the growth impairment phenomenon.
D000818:Animals; D002116:Calcitonin / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism*; D002455:Cell Division / Q000187:drug effects; D005260:Female; D008274:Magnesium / Q000378:metabolism*; D010710:Phosphates / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats; D012513:Sarcoma, Experimental / Q000503:physiopathology*
D010710:Phosphates; D010743:Phospholipids; D002116:Calcitonin; D008274:Magnesium; D002118:Calcium