LDH isozymes in epidermis and skin carcinoma in hamsters.
Lactate dehydrogeanse (LDH) isozymes in the epidermis and in transplantable epidermal carcinoma from Syrian hamsters were studied by polyacrilamide electrophoresis. A 5-band pattern with occasional loss of 1--2 anode fractions in certain tumor samples is typical. In the epidermis of 14 to 15-day-old foetuses, in the regenerating epidermis, and in tumor cells cathode of M subunits predominate, in particular the fifth fraction in the last two cases. In the epidermis from new born, 25-day-old (growing stage of the hairs) and 60 to 80-day-old (resting stage of the hairs) animals a relative increase of the H subunits is striking. These results reveal a foetal-like pattern of LDH isozymes in regenerating and tumorous epidermis, as has been observed in other isozymes and in other tissues.
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000201:enzymology* / Q000648:ultrastructure; D006224:Cricetinae; D004817:Epidermis / Q000201:enzymology / Q000648:ultrastructure; D005260:Female; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000302:isolation & purification*; D008297:Male; D012878:Skin Neoplasms / Q000201:enzymology* / Q000648:ultrastructure
D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase