title: Essential progressive iris atrophy. Report of two cases.
abstract: Chandler's syndrome and essential progressive iris atrophy, we believe, are two entities of the same syndrome. We have presented a case which could be considered a perfect intermediate. The mechanical 'stretch' theory of Campbell et al., supported to an extent by the light and electron microscopic findings of Rodrigues et al., is untenable in view of the observation in our patient that the first, and broad, peripheral anterior synechia was opposite the position of the displacement of the pupil. Every case in which corneal abnormality, glaucoma and iris changes are found, should be checked explicitly, with specular microscopy and gonioscopy, for corneal endothelial changes and in order to locate the area of predilection of peripheral anterior synechiae.
mesh_terms: D000328:Adult; D001284:Atrophy; D003315:Cornea / Q000473:pathology; D003937:Diagnosis, Differential; D004727:Endothelium / Q000473:pathology; D005260:Female; D005451:Fluorescein Angiography; D006068:Gonioscopy; D006801:Humans; D007498:Iris / Q000473:pathology*; D008297:Male; D014603:Uveal Diseases / Q000175:diagnosis