N-demethylation of nicotine and reduction of nicotine-1'-N-oxide by Microsporum gypseum.
Several microorganisms were examined for their abilities to convert S-nicotine into nornicotine. Five microorganisms including Microsporum gypseum (ATCC 11395) produced nornicotine and three unknown metabolites. M. gypseum efficiently reduced nicotine-1'-N-oxide to nicotine, but no nornicotine was obtained when the N-oxide was used as substrate.
D055598:Chemical Phenomena; D002621:Chemistry; D003497:Cyclic N-Oxides / Q000378:metabolism*; D005285:Fermentation; D005658:Fungi / Q000378:metabolism; D008864:Microsporum / Q000378:metabolism*; D009538:Nicotine / Q000031:analogs & derivatives* / Q000378:metabolism*; D010084:Oxidation-Reduction; D013045:Species Specificity
D003497:Cyclic N-Oxides; C024270:nicotine 1-N-oxide; D009538:Nicotine; C005311:nornicotine