Use of labetalol during hypotensive anaesthesia and in the management of phaeochromocytoma.
1 The circulatory effects of labetalol have been studied in 88 patients undergoing plastic surgery, 8 patients with carcinoma of the breast, 10 with carcinoma in the head and neck, and in 2 patients with phaeochromocytoma, each anaesthetized twice. 2 The use of labetalol intravenously produced hypotension and a bloodless operating field in patients undergoing plastic surgery and in those undergoing radical surgery for the removal of carcinoma. 3 Two patients with phaeochromocytoma pre-treated with oral labetalol before anaesthesia, had well controlled BPs and heart rates during surgery, although in one instance additional intravenous labetalol was required. 4 Pre-operative preparation of patients with phaeochromocytoma with labetalol seems to be simpler and safer than previous techniques involving drugs with separate alpha- and beta-adrenoceptor-blocking effects.
D000293:Adolescent; D000310:Adrenal Gland Neoplasms / Q000601:surgery*; D000328:Adult; D000758:Anesthesia; D004983:Ethanolamines / Q000494:pharmacology; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007023:Hypotension, Controlled; D007275:Injections, Intravenous; D007741:Labetalol / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D010673:Pheochromocytoma / Q000601:surgery*; D013514:Surgical Procedures, Operative; D013997:Time Factors
D004983:Ethanolamines; D007741:Labetalol