Fatty acid composition of cholesteryl esters in cholesterol-fed rabbits treated with lipid-lowering agent (ethyl 2-(p-chlorophenoxy) isobutyrate).
Regression mechanism of Ethyl 2-(p-chlorophenoxy) isobutyrate (CPIB) in the arterial wall was studied for elucidation in terms of fatty acid-compositional change in cholesterol-fed rabbits. The following evidence was obtained: (1) The amount of cholesterol and cholesteryl ester in the atheromatous aorta were reduced after CPIB treatment. (2) CPIB resulted in a significant increase in the ratio of linoleate to oleate in both the arterial wall and serum after withdrawal of the cholesterol diet. It is suggested that there is a preferential hydrolysis of linoleate-rich cholesteryl ester in both the arterial wall and the serum.
D000818:Animals; D001011:Aorta / Q000032:analysis; D001161:Arteriosclerosis / Q000378:metabolism; D002784:Cholesterol / Q000032:analysis; D002788:Cholesterol Esters / Q000032:analysis* / Q000097:blood; D002791:Cholesterol, Dietary / Q000008:administration & dosage*; D002994:Clofibrate / Q000494:pharmacology*; D004036:Diet, Atherogenic; D005227:Fatty Acids / Q000032:analysis*; D005260:Female; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D011817:Rabbits
D002788:Cholesterol Esters; D002791:Cholesterol, Dietary; D005227:Fatty Acids; D000960:Hypolipidemic Agents; D002784:Cholesterol; D002994:Clofibrate