title: Attenuation of the gamma-butyrolactone-induced increase in DOPA accumulation by chronic ethanol administration.
abstract: The effect of gamma-butyrolactone (GBL) on the accumulation of dopa after inhibition of aromatic amino acid decarboxylase was studied in rats following chronic treatment with ethanol. The GBL-induced dopa accumulation was significantly decreased in ethanol-treated rats. With the increased duration of the ethanol treatment this effect appears to be more marked in the limbic forebrain. It is suggested that chronic ethanol treatment may produce a decreased sensitivity of central GABA receptors.
mesh_terms: D015107:4-Butyrolactone / Q000494:pharmacology*; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001921:Brain / Q000378:metabolism*; D003342:Corpus Striatum / Q000378:metabolism; D004295:Dihydroxyphenylalanine / Q000378:metabolism*; D000431:Ethanol / Q000494:pharmacology*; D005663:Furans / Q000494:pharmacology*; D008032:Limbic System / Q000378:metabolism; D008297:Male; D051381:Rats
chemical_list: D005663:Furans; D000431:Ethanol; D004295:Dihydroxyphenylalanine; D001058:Apomorphine; D015107:4-Butyrolactone