Effect of hydroxydopamine on the morphine-induced reduction in brain acetylcholine turnover.
Morphine reduced brain acetylcholine turnover in normal and 6-hydroxydopamine-pretreated rats and mice. Morphine probably has a direct effect on cholinergic neurons rather than modifying acetylcholine indirectly through catecholamine neurons. Acetylcholine is not directly involved in morphine's antinociceptive action in the mouse but it could be implicated in the rat.
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D006892:Hydroxydopamines / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology*; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D013045:Species Specificity
D006892:Hydroxydopamines; D009020:Morphine; D000109:Acetylcholine; D009638:Norepinephrine