The influence of SPC-703 on blood pressure in rabbits and rats and on isolated heart of guinea pigs.
New oral hypoglycemic drug, SPC-703, given in doses of 100 and 200 mg/kg iv rised the arterial pressure in the rat. In the experiments in rabbits, a dose of 100 mg/kg iv was without effect, and the dose of 200 mg/kg rised the blood pressure only temporarily. The cumulative doses of SPC-703 given on the Langendorff isolated heart of the guinea pig, significantly increased the contractile force at the dose 135 mg. The mechanism of inotropic effect of the antidiabetic drugs, derivatives of sulfonylurea is discussed.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D003326:Coronary Circulation / Q000187:drug effects; D005260:Female; D006168:Guinea Pigs; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D011720:Pyrazoles / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D013453:Sulfonylurea Compounds / Q000494:pharmacology*; D013997:Time Factors
D007004:Hypoglycemic Agents; D011720:Pyrazoles; D013453:Sulfonylurea Compounds; C009971:glipalamide