Immunoreactive somatomedin B in acromegaly and in Turner's syndrome.
Serum somatomedin B was measured by radioimmunoassay in forty-seven normal subjects, twenty-nine patients with acromegaly before and twenty-four after treatment, and eighteen patients with Turner's syndrome. Somatomedin B levels were significantly elevated in untreated acromegaly and in Turner's syndrome compared with the control group; they decreased following treatment of acromegaly. Because of the overlap between the groups, little information could be obtained from single somatomedin B estimations, which could, therefore, not replace dynamic tests of growth hormone secretion. No correlation between growth hormone and somatomedin B in acromegaly was detected; however, somatomedin B appeared to be related to the insulin response during the oral glucose tolerance test. In Turner's syndrome, no relationship between somatomedin B and insulin production, urinary oestrogen excretion, growth hormone secretion, gonadotrophin levels, age or height was found. The reason for the raised somatomedin B levels in Turner's syndrome remains at present unknown.
D000172:Acromegaly / Q000097:blood*; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D003920:Diabetes Mellitus / Q000097:blood; D004967:Estrogens / Q000652:urine; D005260:Female; D005951:Glucose Tolerance Test; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D013002:Somatomedins / Q000097:blood*; D014424:Turner Syndrome / Q000097:blood*
D004967:Estrogens; D007328:Insulin; D013002:Somatomedins; D013006:Growth Hormone