Strain-difference in circadian murine chronotolerance to the antidepressant drug nomifensine.
The anti-depressant drug nomifensine (8-amino-1,2,3,4-tetrahydro-methyl-4-phenylisoquinoline) was administered at several dose levels to mice of 2 inbred strains at one of 6 circadian times 4h apart under conditions standardized for light-dark synchronized rhythmometry. A circadian rhythm in tolerance to nomifensine reflected by differences in mortality was demonstrated for both C57 and DBA mice. An interstrain difference in tolerance was also observed.
D000818:Animals; D002940:Circadian Rhythm / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004361:Drug Tolerance; D005260:Female; D007546:Isoquinolines / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008954:Models, Biological; D009627:Nomifensine / Q000494:pharmacology*; D013045:Species Specificity
D007546:Isoquinolines; D009627:Nomifensine