Antagonism by d,1-propranolol of imipramine effects in mice.
Three agents with known or suspected antidepressant activity, imipramine, salbutamol and dexamphetamine, were active in animal tests predictive of an antidepressant effect in man: antagonism of the hypothermia induced by reserpine, by oxotremorine or by a high dose of apomorphine, and the potentiation of the yohimbine-induced toxicity. These effects were antagonized by d,1-propranolol, suggesting that the stimulation of beta-adrenergic receptors could be a common mechanism underlying their effects. These results agree with the noradrenergic hypothesis of the pathophysiology of affective disorders.
D000420:Albuterol / Q000037:antagonists & inhibitors; D000818:Animals; D001058:Apomorphine / Q000037:antagonists & inhibitors; D001831:Body Temperature / Q000187:drug effects; D003913:Dextroamphetamine / Q000037:antagonists & inhibitors; D004347:Drug Interactions; D007099:Imipramine / Q000037:antagonists & inhibitors*; D008297:Male; D051379:Mice; D010095:Oxotremorine / Q000037:antagonists & inhibitors; D011433:Propranolol / Q000494:pharmacology*; D012110:Reserpine / Q000494:pharmacology; D015016:Yohimbine / Q000633:toxicity
D015016:Yohimbine; D010095:Oxotremorine; D012110:Reserpine; D011433:Propranolol; D001058:Apomorphine; D007099:Imipramine; D000420:Albuterol; D003913:Dextroamphetamine