Reconstruction of articular cartilage with free autologous perichondrial grafts. An experimental study in rabbits.
An experimental study in adult rabbits has been performed to find out whether the cartilage forming capacity of the perichondrium could be utilized in reconstruction of articular cartilage. The normal articular cartilage of the glenoid surface of the humero-scapular joint was completely removed. Auricular perichondrium was grafted to cover the exposed bony surface with the active chondrogenic layer of the perichondrial graft facing the joint cavity. The joint was not immobilized but the operated limb was amputated at wrist level to avoid weight bearing. The animals were sacrificed at different time intervals ranging from 1 to 17 weeks. In 12 out of 14 grafted rabbits regeneration of cartilage occurred. In 6 of 10 control cases where no perichondrium was grafted to cover the resected surface no cartilage was found. In the other 4, only small areas of mature cartilage were seen, probably remnants of the original articular cartilage.
D000671:Amputation, Surgical; D000818:Animals; D001705:Bioprosthesis; D002356:Cartilage / Q000637:transplantation*; D002358:Cartilage, Articular / Q000473:pathology / Q000502:physiology / Q000601:surgery*; D004425:Ear Cartilage / Q000637:transplantation; D005260:Female; D005552:Forelimb / Q000601:surgery; D007595:Joint Prosthesis / Q000379:methods*; D008297:Male; D011817:Rabbits; D012038:Regeneration; D012785:Shoulder Joint / Q000473:pathology / Q000601:surgery; D014182:Transplantation, Autologous