Modification by levo-propranolol of tremors induced by harmine in mice.
It has been recently reported that the levo isomer of propranolol possesses anti-serotonin properties in animals. Since harmine-induced behavioural changes in mice are reported to be mediated through central serotonergic receptors, an attempt was made to test whether 1-propranolol would also modify harmine-induced responses by virtue of its anti-serotonergic or anti-adrenergic property. The results indicated that l- and dl-propranolol inhibited central serotonin receptor mediated responses to harmine in mice, a finding that is analogous to other recent observations.
D000818:Animals; D003533:Cyproheptadine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006247:Harmine; D008297:Male; D051379:Mice; D010643:Phenoxybenzamine / Q000494:pharmacology; D011217:Practolol / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014202:Tremor / Q000139:chemically induced / Q000503:physiopathology*
D010643:Phenoxybenzamine; D003533:Cyproheptadine; D006247:Harmine; D011433:Propranolol; D011217:Practolol