[Effect of ubiquinones and their analogs on the respiratory chain enzyme activity of Candida guilliermondii yeasts].
The effect of ubiquinones with different length of their chain (CoQ0, CoQ1, CoQ2, CoQ6, CoQ9) and their synthetic analogues (analogues of ubiquinone-1, hexahydroubiquinone-4, monophytylquinone, diphytylquinone, triphytylquinone) on the activity of ubiquinone dependent enzyme systems was studied in mitochondrial fractions from the yeast Candida guilliermondii. All of the ubiquinone homologues studied activated these systems. The synthetic analogues of ubiquinone nonspecifically inhibited the activity of NADH2-oxidase system. The inhibition was reversible when CoQ0 and CoQ1, but not CoQ6 and CoQ9, were added to the system. In the succinate-CoQ-reductase system, the inhibition caused by the analogues of ubiquinone was eliminated when all of the tested homologues were added to the system. In contrast to other analogues of ubiquinone, hexahydroubiquinone-4 was an inhibitor for the NADH2-oxidase system and an activator for the succinate-CoQ-reductase system, and eliminated the inhibiting action of other ubiquinone analogues in this system. Similar action of ubiquinone homologues was shown in the elimination of the inhibition of ubiquinone dependent systems caused by the specific inhibitors of electron transport, viz. rotenone and antimycin A.
D000968:Antimycin A / Q000494:pharmacology; D002175:Candida / Q000187:drug effects / Q000378:metabolism*; D004579:Electron Transport; D008928:Mitochondria / Q000187:drug effects; D009097:Multienzyme Complexes / Q000378:metabolism; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism; D010088:Oxidoreductases / Q000378:metabolism; D012402:Rotenone / Q000494:pharmacology; D013385:Succinate Dehydrogenase / Q000378:metabolism; D014451:Ubiquinone / Q000031:analogs & derivatives / Q000494:pharmacology*
D009097:Multienzyme Complexes; D012402:Rotenone; D014451:Ubiquinone; D000968:Antimycin A; D010088:Oxidoreductases; D013385:Succinate Dehydrogenase; D009247:NADH, NADPH Oxidoreductases
Vliianie ubikhinonov i ikh analogov na aktivnost' fermentov dykhatel'noĭ tsepi u drozhzheĭ Candida guilliermondii.