[Neurochemical mechanisms of the effect of euphylline in cerebral blood flow deficiency].
In cerebral blood flow deficiency the level of ammonia in the cerebral tissue is appreciably increased and the activity of glutamate dehydrogenase (GDH) is decreased without material variations in the content of glutamine and amide groups of protein. Favouring normalization of the deranged cerebral blood flow, euphylline neutralizes excess ammonia by means of GDH activity recovery in the reduction amination reaction. The drug exhibited the most pronounced effect during acute cerebral ischemia. This indicates that euphylline influences the neurochemical mechanisms of the compensatory regulation of cerebral blood flow.
D000628:Aminophylline / Q000494:pharmacology*; D000641:Ammonia / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D005969:Glutamate Dehydrogenase / Q000378:metabolism; D051381:Rats
D000628:Aminophylline; D000641:Ammonia; D005969:Glutamate Dehydrogenase
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