Concerning the role of endogenous copper in the acute inflammatory process.
The development of two models of acute inflammation (carrageenan-induced foot oedema and pleurisy) was studied in rats after 1 month of a 0.2 p.p.m. copper-deficient diet and after 5 months of a 0.6-0.8 p.p.m. copper-deficient diet. A 'pro-inflammatory' effect of copper deficiency was observed with the 0.2 p.p.m. diet, whilst no effect was evident following the 0.6-0.8 p.p.m. copper deficient diet. These results are briefly commented upon.
D000208:Acute Disease; D000818:Animals; D002351:Carrageenan; D003300:Copper / Q000172:deficiency / Q000502:physiology*; D004487:Edema / Q000139:chemically induced / Q000503:physiopathology; D005260:Female; D007249:Inflammation / Q000503:physiopathology*; D010998:Pleurisy / Q000139:chemically induced / Q000503:physiopathology; D051381:Rats; D013997:Time Factors
D003300:Copper; D002351:Carrageenan