Semisynthetic beta-lactam antibiotics. II Cephalosporin derivatives in the naphthalene series. Chemical and microbiological properties.
A seris of new 7-acylamidocephalosporins, containing a substituted naphthalene moiety in the side chain, has been prepared and tested for their in vitro antibacterial activity. Some observations are made on the structure-activity relationships.
D001419:Bacteria / Q000187:drug effects; D002511:Cephalosporins / Q000032:analysis / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D009281:Naphthalenes; D013329:Structure-Activity Relationship
D002511:Cephalosporins; D009281:Naphthalenes