title: Isolation, identification and quantitation of urinary organic acids.
abstract: An application of the HISLIB program for the comparison of gas chromatographic-mass spectrometric profiles of urinary organic acids isolated by extraction and ion-exchange methods is described. Ion-exchange methods are clearly superior to solvent extraction in terms of the variety of compounds isolated. However, the former method has practical difficulties which make solvent extraction more attractive for rapid analyses. For the compounds isolated by both methods, the precision of analysis is similar, with standard deviations of relative concentration in the range 10--30% for most compounds.
mesh_terms: D000328:Adult; D002264:Carboxylic Acids / Q000302:isolation & purification / Q000652:urine*; D002849:Chromatography, Gas / Q000379:methods; D002852:Chromatography, Ion Exchange / Q000379:methods; D003201:Computers; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D006801:Humans; D008297:Male
chemical_list: D002264:Carboxylic Acids