Persistence of antibody titers after vaccination with rubella virus vaccine ("Cendehill" strain).
In 1967-1968 a trial of "Cendehill strain" rubella vaccine was initiated in a group of 3 to 22 year-old prescreened seronegative girls, most being between 8 and 16 years of age. Sera from the vaccinees were taken at regular intervals during a period of 8 to 10 years. The evolution of the antibodies was followed over this period. No antibody titer change was observed in 75 to 78% of the sera. A four fold increase was shown in 6 to 10% and a four fold decrease in 15% of the vaccinees. All sera still showed a positive titer at the end of the period. The importance of these results for the final objective of rubella vaccination will be discussed.
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D012409:Rubella / Q000517:prevention & control; D012411:Rubella Vaccine / Q000627:therapeutic use*; D012412:Rubella virus / Q000276:immunology*; D014611:Vaccination
D000914:Antibodies, Viral; D012411:Rubella Vaccine