[Hypopituitarism and hyperlipidemia. Protective effect of growth hormone deficiency against atherosclerosis (author's transl)].
Twelve cases of hypopituitarism (Sheehan's syndrome, pituitary adenoma, idiopathic) associated with hyperlipidemia (type IIb in general) are reported. It is suggested that: 1 - Growth hormone deficiency seems to have a protective effect against atherosclerosis in hyperlipidemia because there are no cardiovascular signs in 10 cases with a history of growth hormone deficiency lasting from 5 to 57 years and a patent hyperlipidemia (lasting a mean of 23 years), and there is stabilisation or improvement of ischemic signs in 2 other cases. 2 - Lipid abnormalities are frequently seen in hypopituitarism even after thyroid replacement therapy. 3 - The hyperlipidemia can be familial or can result from growth hormone deficiency alone.
D000328:Adult; D000368:Aged; D001161:Arteriosclerosis / Q000517:prevention & control*; D001794:Blood Pressure; D005260:Female; D013006:Growth Hormone / Q000172:deficiency*; D006801:Humans; D006949:Hyperlipidemias / Q000209:etiology*; D007018:Hypopituitarism / Q000150:complications; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000209:etiology; D012907:Smoking / Q000150:complications
D013006:Growth Hormone
Carence en somathormone: effet protecteur contre le développement de l'athérosclérose. A propos de 12 observations associant hypopituitarisme et hyperlipidémie.