Synthesis of 6-O-cyclopyrimidine nucleosides and their physicochemical properties.
Treatment of 5-iodopyrimidine nucleosides with sodium methoxide afforded 6:2'-, 6:5'- and novel 6:3'-O-cyclopyrimidine nucleosides. The rates of cyclization and ring-opening, and the UV-, CD-, mass- and 13C-NMR spectra of the cyclonucleosides were compared with regard to their isomers.
D002942:Circular Dichroism; D007536:Isomerism; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008722:Methods; D009712:Nucleotides, Cyclic / Q000138:chemical synthesis*; D011741:Pyrimidine Nucleosides; D011742:Pyrimidine Nucleotides / Q000138:chemical synthesis*; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship
D009712:Nucleotides, Cyclic; D011741:Pyrimidine Nucleosides; D011742:Pyrimidine Nucleotides