Effects of anti-interferon serum on growth and regression of Moloney sarcoma virus induced tumours in mice.
Administration of sheep anti-mouse interferon serum or globulin to weanling BALB/c mice infected with Moloney sarcoma virus (MSV) accelerated the growth of tumours at the site of virus inoculation, increased the number and size of tumours, and inhibited their regression. The outcome of the MSV-induced disease after injection of anti-interferon globulin depended on the age of mice. The antigenic stimulation by normal sheep serum or globulin also enhanced the growth and mortality due to MSV but to a significantly lesser extent than anti-interferon globulin.
D000818:Animals; D000831:Animals, Newborn; D005260:Female; D007106:Immune Sera; D007136:Immunoglobulins; D007372:Interferons / Q000276:immunology* / Q000502:physiology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D008979:Moloney murine leukemia virus; D012513:Sarcoma, Experimental / Q000503:physiopathology*; D012756:Sheep / Q000276:immunology
D007106:Immune Sera; D007136:Immunoglobulins; D007372:Interferons