[Effect of behavior changing drugs, imipramine and tranylcypromine, on the composition of the blood and activity of the alkaline leukocytophosphatase of emotive and non-emotive adult male Wistar rats].
The corpuscular composition of the blood and the alcalic leucocytophosphatase (ALP) activity was measured for a total of 40 emotive and non-emotive adult male Wistar rats in order to test the influence of a single dose of imipramine (IMI) and tranylcypromine (TRAN) as well as of IMI and TRAN given in a period of 8 days. Special attention was paid to the reaction type of the animals. Changes in the red and white components of the blood were found due to drug application and to reaction type. The relationship between reaction type and drug application we assumed to exist was confirmed. The ALP activity also changed depending on the type of drug dosage. The assumption that ALP activity is higher for emotive rats than for non-emotive ones was confirmed as well.
D000469:Alkaline Phosphatase / Q000097:blood*; D000818:Animals; D001773:Blood Cells / Q000187:drug effects*; D004644:Emotions / Q000502:physiology*; D007099:Imipramine / Q000494:pharmacology*; D007962:Leukocytes / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D051381:Rats; D014191:Tranylcypromine / Q000494:pharmacology*
D014191:Tranylcypromine; D000469:Alkaline Phosphatase; D007099:Imipramine
Einfluss verhaltensändernder Psychopharmaka--Imipramin und Tranylcypromin--auf das Blutbild und auf die Aktivität der alkalischen Leukozytenphosphatase bei emotiven und nichtemotiven Wistar-Ratten.