title: Is clonidine an adenosine antagonist?
abstract: Clonidine has been reported to possess the ability to block the depressant actions of purine compounds on the firing of rat cerebral cortical neurons. In studies on rats anaesthetized either with nitrous oxide and methoxyflurane or urethane, it was not possible to confirm this observation. Rather clonidine enhanced the depressant actions of iontophoretically applied adenosine and adenosine 5'-monophosphate (5'-AMP).
mesh_terms: D000241:Adenosine / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D000249:Adenosine Monophosphate / Q000008:administration & dosage / Q000494:pharmacology; D000768:Anesthesia, General; D000818:Animals; D003000:Clonidine / Q000008:administration & dosage / Q000494:pharmacology*; D003864:Depression, Chemical; D004357:Drug Synergism; D008297:Male; D008733:Methoxyflurane; D009609:Nitrous Oxide; D051381:Rats; D013003:Somatosensory Cortex / Q000187:drug effects*; D014520:Urethane
chemical_list: D008733:Methoxyflurane; D014520:Urethane; D000249:Adenosine Monophosphate; D009609:Nitrous Oxide; D000241:Adenosine; D003000:Clonidine