[Fibrinogen metabolism and plasma fibrinopeptide A in disseminated neoplasms].
FPA immunoreactivity was elevated in 14 out of 15 patients with disseminated neoplasia. Two of the patients showed signs of DIC, two had clinically evident thrombosis and one a positive 125I-fibrinogen uptake test suggesting thrombosis. Infusion of heparin produced a prompt fall in FPA levels. FPA immunoreactivity correlated well with the turnover of intravasal 125I-fibrinogen. The results confirm that the RIA of FPA provides a specific and quantitative index of the conversion of fibrinogen into fibrin and indirectly of the thrombin action in vivo.
D004211:Disseminated Intravascular Coagulation / Q000378:metabolism; D005340:Fibrinogen / Q000097:blood* / Q000378:metabolism*; D005344:Fibrinopeptide A / Q000097:blood*; D006493:Heparin / Q000494:pharmacology; D006801:Humans; D007457:Iodine Radioisotopes; D009369:Neoplasms / Q000378:metabolism*; D011863:Radioimmunoassay; D013927:Thrombosis / Q000378:metabolism
D007457:Iodine Radioisotopes; D005344:Fibrinopeptide A; D005340:Fibrinogen; D006493:Heparin
Fibrinogenmetabolismus und Fibrinopeptid A im Plasma bei disseminierten Malignomen.