[Influence of phenobarbital on hyperbilirubinemia caused by nicotinic acid and rifamycin--SV in healthy subjects].
Ten healthy subjects have been given before and after treatment with phenobarbital the following intravenous charges: a) nicotinic acid; b) rifamicyn-SV; c) simultaneous administration of the two drugs. Along with confirmatory evidence of the wellknown increase in bilirubinaemia (prevalently unconjugated), we have observed phenobarbital to attempts partially yet significantly that effect. On the base of direct experience on rat liver, we hypothise phenobarbital to increase the pool of the Y protein carrying cholephilic organic anions into the hepatocytes.
D000328:Adult; D005260:Female; D006801:Humans; D006932:Hyperbilirubinemia / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D009539:Nicotinic Acids / Q000009:adverse effects*; D010634:Phenobarbital / Q000627:therapeutic use*; D012294:Rifamycins / Q000009:adverse effects*
D009539:Nicotinic Acids; D012294:Rifamycins; D010634:Phenobarbital
Influenza di fenobarbital sull'i perbilirubinemia da acido nicotinico e rifamicina-SV in soggetti sani.