Effect of O-(beta-hydroxyethyl)-rutoside on wound healing in the rat.
The administration of O-(beta-hydroxyethyl)-rutoside in 11 daily doses of 300--400 mg/kg p.o. stimulates wound healing by granulation in the rat. The preparation may counteract the inhibitory effect of prednisone on the formation of granulation tissue. In five doses of 300--1,000 mg/kg daily p.o. it augments the tensile strength of cicatricial tissue to a statistically significant degree.
D000818:Animals; D004353:Drug Evaluation, Preclinical; D006896:Hydroxyethylrutoside / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D011241:Prednisone / Q000037:antagonists & inhibitors; D051381:Rats; D012431:Rutin / Q000031:analogs & derivatives*; D013718:Tensile Strength / Q000187:drug effects; D014945:Wound Healing / Q000187:drug effects*
D006896:Hydroxyethylrutoside; D012431:Rutin; D011241:Prednisone