title: Definitive disruption of spatial delayed alternation in rats after lesions in the ventral mesencephalic tegmentum.
abstract: Prefrontal system dysfunction are revealed in rats in delayed response tasks. In view of the anatomical projections existing from the ventral mesencephalic tegmentum to the prefrontal system we have done this research in order to determine whether cognitive processes are impaired after mesencephalic lesions. Rats learned spatial delayed alternation in a T-maze. After acquisition they were randomly divided in two groups; the experimental group received lesions in the ventral mesencephalic tegmentum at the level of the A10 cell bodies. These lesions induced definitive disruption of the retention of the delayed alternation and the rats were unable to relearn the task. However, these animals were able to perform normally in an operant conditioning with food reinforcement indicating the specificity of the deficit observed with respect to the delayed alteration task. The possible modulating role of dopaminergic A10 neurones is hypothetized.
mesh_terms: D000818:Animals; D001931:Brain Mapping; D003216:Conditioning, Operant / Q000502:physiology*; D004298:Dopamine / Q000502:physiology; D008032:Limbic System / Q000502:physiology; D008297:Male; D008568:Memory / Q000502:physiology*; D051381:Rats; D012055:Reinforcement Schedule; D012153:Retention, Psychology / Q000502:physiology*; D013028:Space Perception / Q000502:physiology; D013681:Tegmentum Mesencephali / Q000502:physiology*
chemical_list: D004298:Dopamine