Altered glucose tolerance in carbon disulfide exposed workers.
Oral cortisone glucose tolerance tests were performed in 66 CS2-exposed workers and in 66 individually matched control subjects. Results indicate a higher and significant (p less than 0.001) prevalence of latent diabetes in the CS2-exposed group (72.7%) as compared with the control group (16.7%), and the existence of a positive and significant (p less than 0.001) correlation between blood glucose values and exposure index. Possible mechanisms of action involving zinc metabolism and pyridoxine metabolism are discussed.
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D002246:Carbon Disulfide / Q000506:poisoning*; D003348:Cortisone / Q000378:metabolism; D003920:Diabetes Mellitus / Q000139:chemically induced* / Q000378:metabolism; D005951:Glucose Tolerance Test; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced* / Q000378:metabolism; D010179:Pancreas / Q000378:metabolism*; D011736:Pyridoxine / Q000378:metabolism; D013783:Textile Industry; D015032:Zinc / Q000378:metabolism
D001786:Blood Glucose; D015032:Zinc; D011736:Pyridoxine; D002246:Carbon Disulfide; D003348:Cortisone