title: The importance of the terminal hemi-acetal group for the ionophoric properties of nigericin.
abstract: Opening of the terminal hemi-acetal in dihydronigericin drastically reduces the ionophoric properties of nigericin and dehydroxymethylnigericin with 6 intact heterocycles. This is shown by 2 complementary methods, first with a liquid membrane electrode system, secondly by testing their ionophoric activities in rat liver mitochondria.
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001692:Biological Transport / Q000187:drug effects; D005971:Glutamates / Q000378:metabolism; D007700:Kinetics; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D009550:Nigericin / Q000494:pharmacology*; D011188:Potassium / Q000378:metabolism; D051381:Rats; D013329:Structure-Activity Relationship; D014634:Valinomycin / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D005971:Glutamates; D014634:Valinomycin; D009550:Nigericin; D011188:Potassium