Pulmonary hyaline membrane disease occurring in the course of VM-26 therapy.
During treatment with VM-26 a 20-year-old patient with metastatic medulloblastoma developed an acute, fulminating pulmonary illness. Open lung biopsy revealed advanced alveolar hyaline membrane formation with interstitial round cell infiltrate. This is the first reported case of podophyllotoxin-related pulmonary disease.
D000328:Adult; D001932:Brain Neoplasms / Q000188:drug therapy; D002330:Carmustine / Q000009:adverse effects; D006801:Humans; D008297:Male; D008527:Medulloblastoma / Q000188:drug therapy; D011034:Podophyllotoxin / Q000031:analogs & derivatives*; D012128:Respiratory Distress Syndrome / Q000139:chemically induced* / Q000473:pathology; D013713:Teniposide / Q000009:adverse effects*
D013713:Teniposide; D011034:Podophyllotoxin; D002330:Carmustine