Alteration of the porphyrin nucleus of cytochrome P-450 caused in the liver by treatment with allyl-containing drugs. Is the modified porphyrin N-substituted?
A spectral study was carried out of the green pigments produced by allyl-containing drugs and a comparison made with N-methylated octaethylporphyrin and 2,4-diformyldeuteroporphyrin. The green pigments resemble the former (and markedly differ from the latter) in the intensity of the bathochromic shifts, titration curves with trifluoroacetic acid and rate of incorporation of metal ions in vitro.
D000498:Allyl Compounds / Q000494:pharmacology*; D000818:Animals; D002413:Cations, Divalent / Q000378:metabolism; D055598:Chemical Phenomena; D002621:Chemistry; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D011166:Porphyrins / Q000378:metabolism*; D051381:Rats; D013053:Spectrophotometry
D000498:Allyl Compounds; D002413:Cations, Divalent; D011166:Porphyrins; D003577:Cytochrome P-450 Enzyme System