Metabolic studies in rats under glucose and glycerol loading.
It has been found in rats that 40% glycerol, when added to standard diet, reduces the food intake and thus prevents weight gain. The subcutaneous application (40 mg/kg three times daily) has no effect. Under pair feeding conditions the oxygen consumption, the RQ value and body weight remain unaffected as compared with controls receiving glucose. It is concluded that reduction of body weight induced by glycerol feeding is due to reduced amount of food intake and not due to any alterations of energy metabolism.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight / Q000187:drug effects; D002245:Carbon Dioxide / Q000502:physiology; D004435:Eating / Q000187:drug effects; D004734:Energy Metabolism / Q000187:drug effects*; D005947:Glucose / Q000008:administration & dosage / Q000494:pharmacology*; D005990:Glycerol / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D007279:Injections, Subcutaneous; D008297:Male; D010100:Oxygen / Q000502:physiology; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D012119:Respiration / Q000187:drug effects
D001786:Blood Glucose; D002245:Carbon Dioxide; D005947:Glucose; D005990:Glycerol; D010100:Oxygen