The effects of actinomycin D and chloramphenicol on the rat preimplantation embryos.
Actinomycin D and chloramphenicol, injected in the rat on day 3 or 4 of gestation, induce embryolethality and embryotoxicity. These effects are revealed on day 5 of pregnancy by reduced number of blastocysts and by decrease of mean blastomeres number.
D000818:Animals; D001755:Blastocyst / Q000187:drug effects / Q000502:physiology*; D002701:Chloramphenicol / Q000494:pharmacology*; D003609:Dactinomycin / Q000494:pharmacology*; D010064:Embryo Implantation; D005260:Female; D011247:Pregnancy; D051381:Rats
D003609:Dactinomycin; D002701:Chloramphenicol