Viral hepatitis B and Wiskott-Aldrich syndrome.
A 4-year-old boy affected by Wiskott-Aldrich syndrome had overt viral hepatitis B after repetitive blood transfusions. He was given immune serum containing HBs antibodies, with only transient improvement. The HBsAg titer decreased immediately after each administration of immune serum, but 2 days later it was higher than before. This effect could be explained by the presence of HBs antigen-HBs antibody complexes in the immune serum, not detected by the current testing procedure.
D002675:Child, Preschool; D006509:Hepatitis B / Q000209:etiology* / Q000628:therapy; D006510:Hepatitis B Antibodies / Q000008:administration & dosage; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006801:Humans; D008297:Male; D065227:Transfusion Reaction; D014923:Wiskott-Aldrich Syndrome / Q000150:complications*
D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens