[Dexamethasone-21-phosphate in the treatment of cerebral edema. Evaluation of the effects on diuresis, natremia and natriuria].
An evaluation was made of variations in blood and urinary sodium following the administration of 24 mg/day desamethasone-21-phosphate for at least 9 days, starting from admission, as cerebral antioedemigenic therapy in 30 patients with nerve traumas. The changes observed were within normal limits. This absence of interference with the hydro-electrolyte balance is a strong point in favour of the use of the drug in the treatment of cerebral oedema. The exact mechanism of action of this type of glycocorticoid, however, is still unknown.
D000293:Adolescent; D000328:Adult; D001929:Brain Edema / Q000188:drug therapy* / Q000209:etiology; D001930:Brain Injuries / Q000150:complications; D002648:Child; D003907:Dexamethasone / Q000494:pharmacology / Q000627:therapeutic use*; D004231:Diuresis / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009318:Natriuresis / Q000187:drug effects*; D012964:Sodium / Q000097:blood*
D003907:Dexamethasone; D012964:Sodium
II desametazone-21-fosfato nel trattamento dell'edema cerebrale. Valutazione degli effetti sulla diuresi, natriemia e natriuria.