title: [Heteroarylalkanoic acids with potential anti-inflammatory activity].
abstract: A series of (3-oxodihydro-1,2,4-benzothiadiazin-1,1-dioxide-3-yl)acetic acids [compounds of type (A)] and (1,2,4-benzothiadiazin-1,1-dioxide-3-yl)oxyacetic acids [compounds of type (B)] were synthesised and tested for antiinflammatory activity. Preliminary tests showed certain compounds to have a significant level of antiinflammatory activity in rat paw edema induced by carrageenan. It was found that the antiinflammatory activity of this series of compounds depends on the nature, number and position of the substituents on the benzene ring.
mesh_terms: D000085:Acetates / Q000138:chemical synthesis* / Q000627:therapeutic use; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D001169:Arthritis, Experimental / Q000188:drug therapy; D001581:Benzothiadiazines / Q000138:chemical synthesis* / Q000627:therapeutic use; D005260:Female; D008970:Molecular Weight; D051381:Rats
chemical_list: D000085:Acetates; D000893:Anti-Inflammatory Agents; D001581:Benzothiadiazines
vernacular_title: Acidi eteroarilalcanoici a possibile azione antiinfiammatoria.