Tissue ascorbic acid, fenfluramine, and changes in fat metabolism.
Following initial weight gain, reduction in appetite and pronounced weight loss occurred in scorbutic unsupplemented guinea-pigs. Hepatic ascorbic acid levels were significantly reduced and cholesterol concentration increased in the liver. Fenfluramine administration caused immediate loss of weight and appetite in the scorbutic guinea-pigs, these changes being more pronounced in the males. Hepatic ascorbic acid, cholesterol and triglycerides were reduced to lower levels in the fenfluramine-treated scorbutic animals than in the scorbutic guinea-pigs receiving diet alone. In contrast, weight and appetite increased in vitamin-C-supplemented animals while they were receiving fenfluramine. Their hepatic cholesterol and triglyceride levels became significantly reduced. It has been shown that supplementary vitamin C can inhibit the anti-obesity and anorectic actions of fenfluramine and counteract its effect in raising tissue cholesterol.
D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism* / Q000494:pharmacology; D001206:Ascorbic Acid Deficiency / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D005277:Fenfluramine / Q000037:antagonists & inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D006128:Growth / Q000187:drug effects; D006168:Guinea Pigs; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D009765:Obesity / Q000188:drug therapy / Q000378:metabolism; D012737:Sex Factors; D014280:Triglycerides / Q000378:metabolism
D014280:Triglycerides; D005277:Fenfluramine; D002784:Cholesterol; D001205:Ascorbic Acid