Collagen dysplasia and matrix vesicles. Researches with the electron microscope into the problem of so-called "weakness of the vessel wall".
Quite diverse pathological changes of the wall of a blood-vessel can lead to quantitatively and qualitatively altered collagen, as well as to the production of matrix vesicles. It can be demonstrated morphologically that changes--particularly qualitative changes--in collagen are accompanied by a more or less severe loss of function. Possible causal connections between the appearance simultaneously of matrix vesicles (in which lysosomal enzymes can be demonstrated) and altered vascular collagen are discussed.
D000368:Aged; D000818:Animals; D001158:Arteries / Q000648:ultrastructure; D001808:Blood Vessels / Q000201:enzymology / Q000648:ultrastructure*; D001932:Brain Neoplasms / Q000473:pathology; D003094:Collagen; D003238:Connective Tissue / Q000648:ultrastructure; D003925:Diabetic Angiopathies / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D051381:Rats; D012501:Saphenous Vein / Q000648:ultrastructure; D014680:Veins / Q000648:ultrastructure
D003094:Collagen