title: Phlebotomy improves pulmonary gas exchange in chronic mountain polycythemia.
abstract: There is not unanimous agreement in the literature regarding the effects of bleeding on pulmonary gas exchange in polycythemic patients. Spirometry, alveolar arterial O2 and CO2 tension differences, PaO2 breathing 100% oxygen and carbon monoxide-diffusing capacity were measured before and after 1 week of chronic phlebotomy in 4 chronic mountain polycythemic patients. Studies were carried out at 3,700 m above sea level (PB = 491 mm Hg). Before phlebotomy, 2 patients showed abnormal spirometry and gas exchange. Only 1 patient had high PaCO2 and all of them showed low values of PaO2 breathing oxygen. Phlebotomy improved both spirometry and gas exchange. Improvement in arterial oxygen saturation and PaO2 could not be attributed to changes in alveolar ventilation, but rather to better distribution of VA/Qc ratios since physiological dead space decreased. Our results are similar to those reported in polycythemia vera patients. A significant correlation between the changes in PaO2 with phlebotomy and the control PaO2 have been found from 45 polycythemic patients with chronic obstructive pulmonary disease collected from the literature. It is concluded that excessive polycythemia worsened hypoxemia and that phlebotomy improved gas exchange.
mesh_terms: D000328:Adult; D000368:Aged; D000531:Altitude; D001815:Bloodletting; D002245:Carbon Dioxide / Q000097:blood*; D002908:Chronic Disease; D005541:Forced Expiratory Volume; D006400:Hematocrit; D006801:Humans; D008297:Male; D008450:Maximal Midexpiratory Flow Rate; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D010366:Peak Expiratory Flow Rate; D011086:Polycythemia / Q000097:blood / Q000503:physiopathology / Q000628:therapy*; D011653:Pulmonary Diffusing Capacity; D014797:Vital Capacity
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen