Granulocyte function during prophylaxis with doxycycline.
The influence of doxycycline on granulocyte migration was investigated on patients undergoing fracture surgery. The granulocyte migration of the patients was depressed when doxycycline was administered. Scanning electron microscopy demonstrated a decreased granulocyte adherence to glass as well as a decrease in number of filopods per cell in the presence of doxycycline.
D002448:Cell Adhesion / Q000187:drug effects; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D004318:Doxycycline / Q000627:therapeutic use*; D006098:Granulocytes / Q000187:drug effects* / Q000276:immunology; D006801:Humans; D013530:Surgical Wound Infection / Q000517:prevention & control*
D004318:Doxycycline