Spectrophotometric determination of piperazine and its salts in pharmaceuticals.
A spectrophotometric determination of piperazine and some of its salts is described. The method depends on the UV measurement of the N-nitroso derivatives formed by the interaction of piperazine with nitrous acid. The chromophore is developed by heating the reaction mixture at 80 degrees C for 15 min, at pH 2.3--2.6. Beer's law is obeyed in the range 1--15 micrograms/mL.
D004304:Dosage Forms / Q000032:analysis; D009603:Nitroso Compounds / Q000032:analysis; D010879:Piperazines / Q000032:analysis*; D013056:Spectrophotometry, Ultraviolet
D004304:Dosage Forms; D009603:Nitroso Compounds; D010879:Piperazines