[Diuretic evaluation of bumetanide (author's transl)].
The intravenous administration of 2 mg bumetanide produces a sudden rise in diuresis in a state of hydropenia as well as in a state of previous aqueous diuresis. This rise, which is not accompanied by changes in the glomerular filtrate and renal plasma flow, seems to be due to a decrease in the reabsorption of chloride and sodium in the Henle's loop and probably to a decrease in the absorption of fluid in the proximal tubule, as is apparently indicated by the fractional excretion of water and sodium and the clearance of phosphorus and uric acid.
D000328:Adult; D002034:Bumetanide / Q000008:administration & dosage / Q000494:pharmacology*; D004231:Diuresis / Q000187:drug effects*; D004232:Diuretics / Q000494:pharmacology*; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D007275:Injections, Intravenous; D007668:Kidney / Q000098:blood supply; D009318:Natriuresis / Q000187:drug effects; D009994:Osmolar Concentration; D014868:Water Deprivation; D014882:Water-Electrolyte Balance
D004232:Diuretics; D002034:Bumetanide
Evaluación diurética de la bumetanida.