title: [Severe urinary tract and cutaneous lesions after umbilical cord artery puncture and direct injection of hypertonic sodium bicarbonate to the newborn in the delivery room. Report of three cases (author's transl)].
abstract: Three cases of necrotizing and calcifying lesions of low urinary tract, buttock and adjacent perineum are reported. These lesions have been induced by direct syringe injection into an umbilical artery of 42% sodium bicarbonate solution at the dose of 5 to 6 ml/kg of body weight. Radiographic examinations are very important to study the urinary tract lesions. These have been surgically controlled in two cases. The follow up ranges from 10 to 21 1/2 months. On the bladder initial necrotizing lesions are followed by calcification and parietal retraction. These bladder lesions induce a more or less important ureterohydronephrosis. To these constant lesions are variably associated urethral calcifications and stenosis, distal ureter calcifications. These lesions seem to be related to the sodium bicarbonate hyperosmolality, to the injection conditions, and to the local hemodynamic features.
mesh_terms: D001639:Bicarbonates / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D006982:Hypertonic Solutions; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000000981:diagnostic imaging / Q000209:etiology*; D007269:Injections, Intra-Arterial / Q000009:adverse effects*; D008297:Male; D011859:Radiography; D012871:Skin Diseases / Q000209:etiology*; D014469:Umbilical Arteries; D014570:Urologic Diseases / Q000000981:diagnostic imaging / Q000209:etiology*
chemical_list: D001639:Bicarbonates; D006982:Hypertonic Solutions
vernacular_title: Lésions urinaires et cutanées par ponction d'une artère du cordon ombilical et injection à la serinque de soluté bicarbonaté hypertonique chez le nouveau-né en salle d'accouchement. A propos de trois observations.