Disopyramide plasma levels in cardiac patients on maintenance therapy.
The antiarrhythmic agent disopyramide, in a dosage of 200 mg/8 h, was given to 7 cardiac patients. The drug was fairly rapidly absorbed, and the mean peak plasma concentration (3.5 microgram/ml) was measured 1 h after administration of the first dose. The mean biological half-life (7.8 h) was slightly prolonged compared to that reported in normal volunteer subjects. Mean steady state plasma concentrations within the therapeutic range were attained 24--32 h after the start of medication. The fluctuations in the plasma levels were in the order or 30 percent; however, a wide spread of the values was observed. The drug was well tolerated.
D000328:Adult; D000368:Aged; D004206:Disopyramide / Q000008:administration & dosage / Q000097:blood* / Q000627:therapeutic use; D005260:Female; D006207:Half-Life; D006331:Heart Diseases / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011725:Pyridines / Q000097:blood*; D013997:Time Factors
D011725:Pyridines; D004206:Disopyramide