title: The effect of time on the incidence of carcinomas obtained by the implantation of paraffin wax pellets into mouse bladder.
abstract: Paraffin wax pellets were implanted surgically into the mouse bladder lumen and animals killed after 40-50, 70-80 and 100-110 weeks. The number and malignancy of bladder carcinomas increased considerably with the time after implantation. Pellets containing 1-phenylazo-2-naphthol significantly increased at each time the incidence of bladder carcinomas relative to that observed with paraffin wax. Pellets containing N-2-fluorenylacetamide or its metabolites gave very similar incidences or carcinomas whether or not they were carcinogenic by oral or parenteral administration.
mesh_terms: D015073:2-Acetylaminofluorene; D000818:Animals; D002277:Carcinoma / Q000139:chemically induced*; D005260:Female; D051379:Mice; D009284:Naphthols; D009374:Neoplasms, Experimental / Q000139:chemically induced; D010232:Paraffin; D013997:Time Factors; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced*; D014885:Waxes
chemical_list: D009284:Naphthols; D014885:Waxes; C024336:1-phenylazo-2-naphthol; D010232:Paraffin; D015073:2-Acetylaminofluorene