A gas chromatographic mass spectrometric chemical ionization assay for haloperidol with selected ion monitoring.
A new gas chromatographic mass spectrometric chemical ionization assay for haloperidol with selectedion monitoring is presented which provides for better combined selectivity and sensitivity than previous assays. Levels of haloperidol in 2 ml of human plasma were reproducibly measured down to subnanogram levels. Both methane and methane--ammonia chemical ionization spectra are presented for haloperidol and the internal standard trifluperidol.
D000293:Adolescent; D000328:Adult; D000641:Ammonia; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D006220:Haloperidol / Q000097:blood* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008697:Methane; D011618:Psychotic Disorders / Q000097:blood / Q000188:drug therapy; D014272:Trifluperidol
D000641:Ammonia; D006220:Haloperidol; D008697:Methane; D014272:Trifluperidol