Vasodilating agents in augmentation of skin flap survival.
Skin flap necrosis is a serious problem in reconstructive head and neck surgery. Currently, the only clinically effective means of preventing flap necrosis is delay. Hypothesized mechanisms of delayed and experimental methods of increasing flap survival are discussed. Investigative data supporting the use of phentolamine to augment flap survival are presented.
D000818:Animals; D002746:Chlorpromazine / Q000494:pharmacology; D006085:Graft Survival / Q000187:drug effects*; D006257:Head / Q000601:surgery*; D006830:Hydralazine / Q000494:pharmacology; D008297:Male; D009333:Neck / Q000601:surgery*; D009336:Necrosis / Q000517:prevention & control; D010646:Phentolamine / Q000494:pharmacology*; D051381:Rats; D012867:Skin / Q000098:blood supply; D013524:Surgical Flaps
D006830:Hydralazine; D002746:Chlorpromazine; D010646:Phentolamine