Studies on the modes of action of dicyclohexylamine and related amines with a potentiating effect on noradrenaline responses in the rat vas deferens.
Previous studies have shown that dicyclohexylamine (DCHA) and related amines with saturated and unsaturated cyclic side-chains produce a potentiation of noradrenaline responses in rat vas deferens. The present study shows that the potentiation is mediated via a cocaine-like effect, by acting as neuronal uptake inhibitors on sympathetic nerve terminals of the rat vas deferens. Furthermore, it has been established that the contractions of the vas, which are induced by high concentrations of DCHA and its analogues, are due to an indirect sympathomimetic activity of these compounds.
D000818:Animals; D001596:Benzylamines / Q000494:pharmacology; D003042:Cocaine / Q000494:pharmacology; D003514:Cyclohexylamines / Q000494:pharmacology*; D004357:Drug Synergism; D066298:In Vitro Techniques; D008297:Male; D008729:Methoxamine / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology*; D051381:Rats; D012110:Reserpine / Q000494:pharmacology; D014649:Vas Deferens / Q000187:drug effects
D001596:Benzylamines; D003514:Cyclohexylamines; C011769:dicyclohexylamine; D012110:Reserpine; D008729:Methoxamine; D003042:Cocaine; D009638:Norepinephrine