[An assessement of the in vivo sister chromatid exchange (SCE)-test using various cytostatics (author's transl)].
Five cytostatics of different chemical structure and pharmacological action were used on Chinese hamsters (bone marrow cells) to test the efficiency and validity of the in vivo sister chromatid exchange (SCE)-Test as an indicator of mutagenicity. These model substances, all of which had previously shown a mutagenic effect in one or the other of the various in vivo test systems, gave positive results in this test, too, with the exception of bleomycin. On the basis of the lowest effective dose and the isoeffective doses of the test substances the SCE-test proved to be the most sensitive in vivo mutagenicity test.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001854:Bone Marrow Cells; D002478:Cells, Cultured; D006224:Cricetinae; D003412:Cricetulus; D003434:Crossing Over, Genetic / Q000187:drug effects*; D008677:Metaphase; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D000970:Antineoplastic Agents
Zur Bewertung des In-vivo-SCE(Sister Chromatid Exchange)-Tests, dargestellt an verschiedenen Zytostatika.