Biochemical alterations of connective tissue metabolism in the arterial walls of stroke-prone spontaneously hypertensive rats.
1. The chemical characteristics of the vascular connective tissue components were determined in stroke-prone (SP), stroke-resistant (SR) spontaneously hypertensive (SH) rats and normotensive Wistar-Kyoto (WK) rats. 2. The ratio of hydroxylysine to hydroxylsine plus lysine in the vascular collagen was increased in 6-month-old SP-SH rats and SR-SH rats as compared with WK rats. 3. An age-related increase in uronic acid and hexose content of the aorta was noted in SP-SH, SR-SH and WK rats. However, the increase was more prominent in SH rats, especially SP-SH rats at the stages examined (11 weeks and over 8 months of age). 4. The ratio of galactosyl-hydroxylysine to glucosyl-galactosyl-hydroxylysine in the aortic collagen was decreased in 6-month-old SH rats, especially SP-SH rats as compared with WK rats. 5. A relative increase in beta and gamma components in aortic collagen was noted in 6-month-old SP-SH rats when compared with SR-SH rats. 6. The increased content of uronic acid and hexose and the structural changes of vascular collagen as demonstrated in SP-SH rats might be related to the fragility of the arterial wall and/or to the pathogenesis of stroke-proneness.
D000375:Aging; D000596:Amino Acids / Q000032:analysis; D001158:Arteries / Q000254:growth & development / Q000378:metabolism*; D002561:Cerebrovascular Disorders / Q000150:complications / Q000235:genetics / Q000378:metabolism*; D003094:Collagen / Q000032:analysis; D003238:Connective Tissue / Q000378:metabolism*; D006601:Hexoses / Q000032:analysis; D006973:Hypertension / Q000150:complications / Q000235:genetics / Q000378:metabolism*; D014574:Uronic Acids / Q000032:analysis
D000596:Amino Acids; D006601:Hexoses; D014574:Uronic Acids; D003094:Collagen