Cytochalasin D is able to mimic the effects of phalloidin on the rat liver.
Cytochalasin D induces a strong potassium release in the isolated perfused rat liver and leads to vacuolization of the liver parenchymal cells. These effects are similar to the action of phalloidin on the rat liver. Since phalloidin and cytochalasin act in a different way on microfilaments, it is suggested that any disturbance of the function of microfilaments can induce these effects.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D003572:Cytochalasins / Q000494:pharmacology*; D066298:In Vitro Techniques; D007700:Kinetics; D008099:Liver / Q000378:metabolism* / Q000648:ultrastructure; D008274:Magnesium / Q000494:pharmacology; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology*; D010590:Phalloidine / Q000494:pharmacology*; D011188:Potassium / Q000378:metabolism*; D051381:Rats
D003572:Cytochalasins; D009842:Oligopeptides; D010590:Phalloidine; D008274:Magnesium; D011188:Potassium