[Newborn cardiotoxicity after tocolysis with fenoterolhydrobromide].
In the clinical treatment of imminent premature birth, sympathomimetic amines have greatly increased in importance as an interruptor of labor pains. The purpose of this report is to discuss the clinical findings on the basis of 30 newborns admitted to our hospital (between April 1977 and June 1978) after long-term treatment of the mother and Fenoterol (Partusisten). The predominant clinical findings were: tachycardia, paroxysmal dyspnea, cyanosis, metabolic acidosis, congestive heart failure and, in the ECG, cardiac arrhythmias and T-wave inversions in the left precordial chest leads. A high correlation was found between the clinical degree of alteration and changes in both the ECG and the VCG. In all patients these changes have normalized within 8 weeks. The histological findings of 3 deceased newborns revealed typical although not specific features such as: polyploid cells especially in the subendocardial region and a streamlined fatty degeneration of the myocardium. These findings, however, cannot prove with certainty the cardiotoxic effect of Fenoterol on the myocardium, but it appears possible that an especially high dosage of Fenoterol given i. v. can cause myocardial complications. Our findings suggest that catecholamin derivates should be applicated only with extreme caution.
D000138:Acidosis / Q000139:chemically induced; D003490:Cyanosis / Q000139:chemically induced; D004983:Ethanolamines / Q000009:adverse effects*; D005260:Female; D005280:Fenoterol / Q000009:adverse effects*; D006331:Heart Diseases / Q000139:chemically induced*; D006333:Heart Failure / Q000139:chemically induced; D006801:Humans; D007231:Infant, Newborn; D007745:Labor Onset / Q000187:drug effects; D011247:Pregnancy; D013610:Tachycardia / Q000139:chemically induced; D014672:Vectorcardiography
D004983:Ethanolamines; D005280:Fenoterol
Neugeborenen-Kardiotoxizität nach Tokolyse mit Fenoterolhydrobromid?