title: Hereditary spinal muscular atrophy in Brittany Spaniels: clinical manifestations.
abstract: A progressive neurologic disease was identified in a family of closely related Britanny Spaniel dogs. The disease developed in dogs less than 1 year old and characteristically resulted in paraspinal and proximal pelvic limb muscular atrophy. Neurologic examination, electrodiagnostic testing, and histologic studies indicated that the disease results from motor horn cell degeneration. A colony of affected dogs was established, and breeding studies incriminated an inherited basis for the disease.
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000175:diagnosis / Q000235:genetics*; D004285:Dogs; D005260:Female; D008297:Male; D009046:Motor Neurons; D009133:Muscular Atrophy / Q000175:diagnosis / Q000235:genetics / Q000662:veterinary*; D009460:Neurologic Examination / Q000662:veterinary; D014202:Tremor / Q000662:veterinary