Prostaglandin-sensitive adenylate cyclase in human gastric mucosa. Inhibition by nonsteroid anti-inflammatory agents.
The effects of various nonsteroid anti-inflammatory compounds on human gastric mucosal adenylate cyclase were tested. It is shown that fenamates, indomethacin and diclofenac-Na were relatively specific inhibitors of prostaglandin E2 action at the level of the mucosal cyclase activity. The results suggest that inhibition of prostaglandin E2-activated adenylate cyclase might at least in part contribute to the ulcerogenic effects of certain nonsteroid anti-inflammatory drugs.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D004008:Diclofenac / Q000494:pharmacology; D005753:Gastric Mucosa / Q000201:enzymology*; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology; D011448:Prostaglandin Antagonists / Q000494:pharmacology; D011458:Prostaglandins E / Q000494:pharmacology*; D062367:ortho-Aminobenzoates / Q000494:pharmacology
D000893:Anti-Inflammatory Agents; D011448:Prostaglandin Antagonists; D011458:Prostaglandins E; D062367:ortho-Aminobenzoates; D004008:Diclofenac; D000262:Adenylyl Cyclases; D007213:Indomethacin