Cell proliferation in a malignant angioendothelioma during sequential chemotherapy.
The rate of cellular proliferation was studied in the neoplastic cells of a malignant angioendothelioma and in its inflammatory infiltrate by means of optical radioautography after incorporation ex vivo of tritiated thymidine. One third of the normal looking, as well as the atypical, endothelial cells were engaged in the cell cycle of proliferation. This large pool has been effectively suppressed during subsequent chemotherapy which resulted in partial regression of the neoplasm. The proliferative activity of the infiltrate was higher inside the neoplasm than at its periphery.
D000368:Aged; D001345:Autoradiography; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006390:Hemangioendothelioma / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D012535:Scalp / Q000473:pathology; D012878:Skin Neoplasms / Q000188:drug therapy / Q000473:pathology*; D014747:Vinblastine / Q000627:therapeutic use
D014747:Vinblastine; D004317:Doxorubicin; D003520:Cyclophosphamide; D008727:Methotrexate