Inhibition of testosterone-induced prostate growth in the rat by melatonin-free pineal extract.
Administration of the melatonin-free pineal extract to rats concomitantly receiving testosterone propionate caused partial inhibition of the ventral prostate growth induced by testosterone. Administration of the pineal extract to rats likewise caused a statistically significant decrease in the ventral prostate weight under basal conditions. The mechanism of action is discussed.
D000818:Animals; D006065:Gonadotropins, Pituitary / Q000037:antagonists & inhibitors; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010870:Pineal Gland; D011467:Prostate / Q000187:drug effects* / Q000254:growth & development; D051381:Rats; D013739:Testosterone / Q000494:pharmacology*; D014020:Tissue Extracts / Q000494:pharmacology*
D006065:Gonadotropins, Pituitary; D014020:Tissue Extracts; D013739:Testosterone