Age-associated changes in activities of rat hepatocytes. I. Protein synthesis.
Experiments involving simultaneous comparisons of cells from two animals establish an age-dependent decline in protein synthesis. Specific radioactivities of fractions from cells of aged animals (20+ months) are depressed 60% to 80% versus those from younger animals (2 to 14 months). Isotope ratio patterns derived by PAGE indicate that formation of a 20000 MW polypeptide of cytoribosomal origin is even more strongly and specifically depressed.
D000375:Aging; D000818:Animals; D007930:Leucine / Q000378:metabolism; D008099:Liver / Q000032:analysis / Q000378:metabolism* / Q000648:ultrastructure; D008297:Male; D010452:Peptide Biosynthesis; D014176:Protein Biosynthesis; D051381:Rats; D013347:Subcellular Fractions / Q000378:metabolism
D007930:Leucine