Effect of mepacrine on gastric motility in the rat.
Mepacrine given orally to rats inhibits gastric motility; its blocking effect is comparable to that of chloroquine, papaverine, and drotaverine, but less expressed than that of bencyclane. Similarly as the delayed gastric emptying induced by chloroquine, the effect of mepacrine is antagonized by acetyl-beta-methylcholine in a dose-related fashion, while that of papaverine, drotaverine, and bencyclane remains unchanged after treatment with the cholinomimetic drug.
D000284:Administration, Oral; D000818:Animals; D001537:Bencyclane / Q000494:pharmacology; D002738:Chloroquine / Q000494:pharmacology; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects; D005753:Gastric Mucosa / Q000378:metabolism; D005769:Gastrointestinal Motility / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D010208:Papaverine / Q000031:analogs & derivatives / Q000494:pharmacology; D011796:Quinacrine / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats
D001537:Bencyclane; D002738:Chloroquine; C005317:drotaverin; D010208:Papaverine; D011796:Quinacrine