[Effect of polyunsaturated fatty acids on experimental ulcer in the rat].
The increase of gastric mucosal defensive reachons under linoleic acid loading (20 mg/kg i.m. x 2 x 10 die; 140-220 mg/kg per os x 2 x 15 die), was evaluated in hydrocortisone treated rats (10 mg/kg i.m. x 2 x 10 die) and in rats stressed by immobilisation at a low temperature (at 4 degrees for 1 hour). The incidence and extent of gastric lesions were recorded, in both samples treated differentialy, and in control groups. Although the results were not similarly significant in every case, the capacity of the linoleic acid administrations in limiting the gastric mucose injury was evident. This protective capacity is not dependent on the lesive agent.
D000818:Animals; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D005260:Female; D006854:Hydrocortisone / Q000009:adverse effects; D008041:Linoleic Acids / Q000494:pharmacology; D051381:Rats; D012149:Restraint, Physical; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000209:etiology
D005231:Fatty Acids, Unsaturated; D008041:Linoleic Acids; D006854:Hydrocortisone
Effetti degli acidi grassi polinsaturi sull'ulcera sperimentale del ratto.