[Tumor associated antigens induce humoral and cellular immune response to laryngeal carcinomas (author's transl)].
Tissue from larynx carcinomas or cultured tumor cells were incubated in the presence of patient's sera and binding of IgG antibodies was measured. Sera of 47 from 50 patients showed antibodies against their own malignomas. Furthermore 20% possessed antibodies crossreacting with isolated cultured larynx carcinoma cells. Moreover lymphocytes prepared from patient's blood lysed isolated carcinoma cells. The experiments suggest the presence of tumor associated antigens on the surface of larynx carcinoma cells.
D000912:Antibodies, Neoplasm / Q000032:analysis; D000951:Antigens, Neoplasm / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology; D001666:Binding Sites, Antibody; D003429:Cross Reactions; D003601:Cytotoxicity Tests, Immunologic; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D066298:In Vitro Techniques; D007822:Laryngeal Neoplasms / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology
D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D007074:Immunoglobulin G
Tumorantigene induzieren humorale und zelluläre Immunantworten bei Larynxkarzinomen.