title: [Plasma levels of phenobarbital in epileptic children. Effect of combination with other anticonvulsants].
abstract: The effect of age on the steady state levels of phenobarbitone, alone and when given with phenytoin, sodium valproate and ethosuccimide has been measured in 1 361 children whose ages ranged from one month to 12 years. The relationship between dose and plasma level differed in those under 2 years from those aged between 2 years and 12 years. The addition of the other drugs altered the pharmacokinetics of phenobarbitone.
mesh_terms: D000367:Age Factors; D000927:Anticonvulsants / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D004827:Epilepsy / Q000188:drug therapy / Q000378:metabolism*; D006801:Humans; D007223:Infant; D010634:Phenobarbital / Q000008:administration & dosage / Q000097:blood* / Q000627:therapeutic use
chemical_list: D000927:Anticonvulsants; D010634:Phenobarbital
vernacular_title: Concentration plasmatique du phénobarbital chez l'enfant épileptique. Influence des associations à d'autres anticonvulsivants.