title: Toxicity of 1,4-dihexylpiperazine.
abstract: Attempts to synthesize the insect repellent, N,N'-dihexyl-N-carbomethoxyethylenediamine, led to an impurity which exhibited strong toxicity in the rabbit eye irritation test. Isolation of the impurity led to its identification at 1,4-dihexylpiperazine.
mesh_terms: D000818:Animals; D004340:Drug Contamination; D005123:Eye / Q000187:drug effects; D007302:Insect Repellents / Q000138:chemical synthesis / Q000633:toxicity*; D007509:Irritants; D010879:Piperazines / Q000138:chemical synthesis / Q000633:toxicity*; D011817:Rabbits; D013997:Time Factors
chemical_list: D007302:Insect Repellents; D007509:Irritants; D010879:Piperazines; C023651:1,4-dihexylpiperazine