Radioiodinated DNA as potential tumor-imaging agent.
Radiolabeled heat-denatured DNA and some related nucleic acids localize in tumor tissue following i.v. administration. Retention of radioactivity by tumors is longer than for other organs and localization of tumor tissues is possible by scintigraphic techniques 8-24 hr after injection.
D000230:Adenocarcinoma / Q000000981:diagnostic imaging; D000818:Animals; D001080:Apurinic Acid / Q000378:metabolism; D003110:Colonic Neoplasms / Q000000981:diagnostic imaging; D006224:Cricetinae; D004247:DNA / Q000378:metabolism*; D005260:Female; D007457:Iodine Radioisotopes; D008114:Liver Neoplasms, Experimental / Q000000981:diagnostic imaging; D008325:Mammary Neoplasms, Experimental / Q000000981:diagnostic imaging; D008647:Mesocricetus; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000000981:diagnostic imaging*; D012343:RNA, Transfer / Q000378:metabolism; D011877:Radionuclide Imaging; D051381:Rats; D014018:Tissue Distribution
D007457:Iodine Radioisotopes; D001080:Apurinic Acid; D004247:DNA; D012343:RNA, Transfer