Modifications of ouabain inhibition of xenon accumulation in red blood cells. Implications regarding cell water structuring.
Ouabain is known to depress uptake of xenon by red blood cells, but it is now found that the depressive effects of phenolsulfonphthalein (PSP) or heavy water are even more marked. Ouabain partly reverses those effects in a manner suggesting it exerts a constant action on xenon exchange regardless of the presence or absence of PSP or D2O. Processes analogous to exchange diffusion between certain anesthetic substances and xenon were also observed. The theoretical consequences of the findings are discussed.
D002463:Cell Membrane Permeability / Q000187:drug effects; D003903:Deuterium / Q000008:administration & dosage; D004058:Diffusion; D004347:Drug Interactions; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D004986:Ether / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D008012:Lidocaine / Q000494:pharmacology; D010042:Ouabain / Q000494:pharmacology*; D010637:Phenolsulfonphthalein / Q000494:pharmacology; D011343:Procaine / Q000494:pharmacology; D014867:Water / Q000378:metabolism; D014978:Xenon / Q000378:metabolism*
D014867:Water; D004986:Ether; D014978:Xenon; D011343:Procaine; D010042:Ouabain; D008012:Lidocaine; D003903:Deuterium; D010637:Phenolsulfonphthalein