Mass fragmentographic determination of tetrahydro-beta-carboline in human blood platelets and plasma.
GLC-mass fragmentography of the heptafluorobutyryl derivative was found to be a sensitive and reliable method for the determination of tetrahydro-beta-carboline (THBC, tryptoline) in human blood platelets and plasma. The concentration of THBC in platelet-rich plasma of eight healthy young adult persons was 9.4 +/- 1.6 (mean +/- SD) ng/ml. It was mainly concentrated in platelets, which usually contained over 50% of total THBC.
D000328:Adult; D001792:Blood Platelets / Q000032:analysis*; D002243:Carbolines / Q000097:blood*; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D006801:Humans; D007211:Indoles / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010949:Plasma / Q000032:analysis*; D010976:Platelet Count / Q000379:methods
D002243:Carbolines; D007211:Indoles; C009804:tryptoline