The effects on urinary kinin excretion of oral salt and water loads in dogs.
Ten dogs received 1 l of 37 degrees C tap water by stomach tube. Urine flow rate increased from 17 +/- 6 ml in the control hour to 285 +/- 25 ml in the second hour following the water intake. The diuresis was paralleled by increased urine kinin excretion from 23 +/- 9 ng/h to 94 +/- 17 ng/h. Urine kallikrein and urine sodium excretions remained unmodified. In seven dogs urine sodium excretion was increased from 0.87 +/- 0.22 mmol/h to 14.9 +/- 1.9 mmol/h by intragastric administration of 2% NaCl. Urine flow moderately increased from 15.1 +/- 2.5 ml/h to 64.3 +/- 15.0 ml/h. Urine kinin excretion was unchanged. The results suggest a relationship between high rates of urine flow and urinary kinin excretion.
D000284:Administration, Oral; D000818:Animals; D004231:Diuresis / Q000187:drug effects; D004285:Dogs; D005260:Female; D007441:Intubation, Gastrointestinal; D007610:Kallikreins / Q000652:urine; D007705:Kinins / Q000652:urine*; D012964:Sodium / Q000652:urine; D012965:Sodium Chloride / Q000008:administration & dosage / Q000494:pharmacology*; D014867:Water / Q000008:administration & dosage / Q000494:pharmacology*
D007705:Kinins; D014867:Water; D012965:Sodium Chloride; D012964:Sodium; D007610:Kallikreins