title: Extradural analgesia in labour. A comparison of 2-chloroprocaine hydrochloride and bupivacaine hydrochloride.
abstract: Chloroprocaine hydrochloride 2% and bupivacaine hydrochloride 0.375% in 10-ml doses of plain solutions were studied in a randomised blind manner as the agents for continuous lumbar extradural analgesia in labour. Twenty-four patients were assessed for the speed of onset, duration of action, degree of motor blockade, dermatomal spread, arterial hypotension, and the incidence of unblocked segments. Chloroprocaine showed a quicker onset time  and a shorter duration of action than bupivacaine. Chloroprocaine exhibited more marked motor blockade and a lower incidence of unblocked segments. The dermatomal spread and effect on arterial pressure were similar in both groups.
mesh_terms: D000293:Adolescent; D000328:Adult; D000767:Anesthesia, Epidural; D000773:Anesthesia, Obstetrical; D002045:Bupivacaine / Q000494:pharmacology; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007700:Kinetics; D007743:Labor, Obstetric; D011247:Pregnancy; D011343:Procaine / Q000031:analogs & derivatives* / Q000494:pharmacology; D011897:Random Allocation
chemical_list: D011343:Procaine; C004616:chloroprocaine; D002045:Bupivacaine