A new synthesis of purine arabinosides by a combination of chemical and enzymatic reaction.
The synthesis of hypoxanthine, 2-chlorohypoxanthine, and 2-methylhypoxanthine arabinoside by an enzymatic transarabinosylation and their chemical conversion to biologically interesting purine arabinosides are described. Some of the synthesized compounds were tested for the inhibition of DNA synthesis in cultured tumor cells.
D000818:Animals; D001087:Arabinonucleosides / Q000138:chemical synthesis* / Q000494:pharmacology; D002460:Cell Line; D004261:DNA Replication / Q000187:drug effects; D004273:DNA, Neoplasm / Q000096:biosynthesis; D004353:Drug Evaluation, Preclinical; D004754:Enterobacter / Q000378:metabolism; D007042:Hypoxanthines; D007939:Leukemia L1210 / Q000378:metabolism; D007942:Leukemia, Experimental / Q000378:metabolism; D008722:Methods; D051379:Mice; D013329:Structure-Activity Relationship
D001087:Arabinonucleosides; D004273:DNA, Neoplasm; D007042:Hypoxanthines