Effects of the analeptic drug, 4-aminopyridine, upon post-operative respiratory depression in patients. A preliminary study.
The analeptic agent, 4-aminopyridine, was given to patients who had undergone elective ear, nose and throat surgery and showed severe central respiratory depression due to intra-operative fentanyl administration. The respiratory depression due to fentanyl was found to be partially antagonised by 4-aminopyridine. In view of these preliminary findings it is suggested that the drug might find a use in combatting postoperative fentanyl-induced respiratory depression.
D000631:Aminopyridines / Q000627:therapeutic use*; D005283:Fentanyl / Q000009:adverse effects; D006801:Humans; D011183:Postoperative Complications / Q000188:drug therapy*; D012119:Respiration / Q000187:drug effects; D012131:Respiratory Insufficiency / Q000188:drug therapy*
D000631:Aminopyridines; D005283:Fentanyl