title: Digoxin acute intoxication: evaluation of the efficiency of charcoal hemoperfusion.
abstract: Since there is no widely used method of reducing the severity of massive digoxin intoxication, the capacity of hemoperfusion with coated, activated charcoal to remove digoxin was evaluated in a case of suicidal digoxin ingestion (25 mg). Seven hours after ingestion the digoxin plasma level was equal to 8.9 ng/ml. This was decreased to 4.5 ng/ml after 6 hr hemoperfusion. The amount of digoxin adsorbed by the column represents 4.8% of the absorbed dose. At a blood flow rate of 170 ml/min, the mean digoxin clearance by hemoperfusion was 44.5 +/- 26.9 ml/min. From these results we conclude that charcoal hemoperfusion in acute digoxin intoxication is of little value.
mesh_terms: D000328:Adult; D002606:Charcoal; D004077:Digoxin / Q000378:metabolism / Q000506:poisoning*; D005260:Female; D006464:Hemoperfusion / Q000379:methods; D006801:Humans; D014018:Tissue Distribution
chemical_list: D002606:Charcoal; D004077:Digoxin