Experimental study of cardiomyopathy induced by glucocorticoids.
Abnormal ECG changes were found in some patients who were treated glucocorticoid during long term. In experimental animals, chronic administration of glucocorticoid resulted abnormal ST and T changes of ECG, increased duration of action potential and induced electron microscopical changes of mitochondria. No significant changes were found in serum and myocardial potassium content.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D009202:Cardiomyopathies / Q000139:chemically induced* / Q000473:pathology; D004285:Dogs; D004562:Electrocardiography; D005938:Glucocorticoids / Q000009:adverse effects*; D006439:Hemodynamics; D008928:Mitochondria / Q000648:ultrastructure; D009206:Myocardium / Q000648:ultrastructure; D011188:Potassium / Q000494:pharmacology; D011817:Rabbits; D051381:Rats
D005938:Glucocorticoids; D011188:Potassium