Drug elimination interactions: analysis using a mathematical model.
A mathematical model was developed to analyze the elimination kinetics of drug interactions in the rat. The model is based on physiological blood flow rates and organ weights and includes Michaelis-Menten equations for enzymatic processes which are involved in the elimination of the drug; competitive inhibition interactions are computed for shared pathways. Using data from the single drugs, the model can simulate the results of experiments of the acute warfarin-BSP interactions in rats.
D000818:Animals; D004347:Drug Interactions; D007700:Kinetics; D008297:Male; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D051381:Rats; D013448:Sulfobromophthalein / Q000378:metabolism; D013997:Time Factors; D014859:Warfarin / Q000378:metabolism
D004364:Pharmaceutical Preparations; D013448:Sulfobromophthalein; D014859:Warfarin