Hydroelectrolytic movements in rat jejunum during the alterations of the mucosa induced by a single injection of 5-fluorouracil.
Transmucosal movements of water and electrolytes were measured in male Wistar rats, using the intestinal perfusion technique after a single intramuscular injection of 40 mg/kg BW of 5-fluorouracil. These movements were studied, daily during 6 days after the injection, in relation to the histological study of mucosa. The results (1) may explain the diarrhoea observed in patients treated with this antimitotic agent; (2) suggest the existence of a secretion in crypts, followed by an incomplete reabsorption by villi; the secretion of crypts or the villus reabsorption are alternatively the driving factor depending on the reciprocal size of villi and crypts.
D000818:Animals; D005472:Fluorouracil / Q000008:administration & dosage / Q000494:pharmacology*; D007273:Injections, Intramuscular; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D007583:Jejunum; D008297:Male; D051381:Rats; D014882:Water-Electrolyte Balance / Q000187:drug effects*
D005472:Fluorouracil