Influence of bromocriptine on plasma levels of prolactin and steroid hormones in the 20th week of pregnancy.
The influence of bromocriptine, a prolactin antagonist, on maternal plasma and amniotic fluid prolactin (PRL) was investigated in two pregnancies at the 20th week with medical indication for abortion. Voluntary consensus of the patients was obtained. Blood sample determinations demonstrated that bromocriptine inhibits the secretion of PRL both in plasma and amniotic fluid. Since no changes were observed in peripheral maternal steroid concentrations of dehydroepiandrosterone, dehydroepiandrosterone-sulfate, delta 4-androstene-3, 17-dione, testosterone, estradiol, estriol, and cortisol, it is concluded that PRL does not seem to affect maternal and fetal adrenal cortex as supposed in amenorrhoic patients with hyperprolactinemia.
D000028:Abortion, Induced; D000728:Androgens / Q000097:blood*; D001971:Bromocriptine; D006063:Chorionic Gonadotropin / Q000097:blood*; D004958:Estradiol / Q000097:blood*; D004964:Estriol / Q000097:blood*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011374:Progesterone / Q000097:blood*; D011388:Prolactin / Q000097:blood*; D011460:Prostaglandins F
D000728:Androgens; D006063:Chorionic Gonadotropin; D011460:Prostaglandins F; D001971:Bromocriptine; D011374:Progesterone; D004958:Estradiol; D011388:Prolactin; D004964:Estriol; D006854:Hydrocortisone