Acute toxicity of micronized 8-methoxypsoralen in rodents.
The acute oral and intraperitoneal LD50 values of micronized 8-Methoxypsoralen were determined in rats and mice. The values obtained in the present study were lower than those previously reported. The suggestion is made that the discrepancy in the LD50 values may possibly be attributed to differences in compound particle size in the preparations used.
D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D007274:Injections, Intraperitoneal; D007928:Lethal Dose 50; D008730:Methoxsalen / Q000633:toxicity*; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010316:Particle Size; D051381:Rats
D008730:Methoxsalen