Treatment of intraocular proliferations with intravitreal steroids.
Autotransplantation of 250,000 tissue cultured fibroblasts from rabbit rump skin into the vitreous cavity results in intravitreal strand formation and traction retinal detachment (27 of 47 eyes, 57%). A single intravitreal injection of 1 mg of dexamethasone alcohol inhibits fibroblast growth as judged by the significantly reduced number of retinal detachments (11 of 46 eyes, 24%).
D000818:Animals; D002478:Cells, Cultured; D003907:Dexamethasone / Q000494:pharmacology / Q000627:therapeutic use*; D005128:Eye Diseases / Q000517:prevention & control; D005347:Fibroblasts / Q000187:drug effects / Q000637:transplantation; D011817:Rabbits; D012163:Retinal Detachment / Q000209:etiology / Q000517:prevention & control*; D014182:Transplantation, Autologous; D014822:Vitreous Body / Q000187:drug effects*
D003907:Dexamethasone