Effect of thyrocalcitonin on renal reabsorption of bicarbonate.
Porcine thyrocalcitonin (TCT) given intramuscularly at a dose of 2-3 MRC units/kg body weight induces a renal bicarbonate wasting probably at the level of the proximal tubule. This effect is found in normal children as well as in patients with renal tubular acidosis and with vitamin D deficiency. The mechanism by which TCT acts on the acidification mechanism is probably independent of parathyroid hormone (PTH) because the effect could also be obtained in hypoparathyroid patients.
D000042:Absorption; D001639:Bicarbonates / Q000378:metabolism*; D002116:Calcitonin / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007011:Hypoparathyroidism / Q000378:metabolism; D007223:Infant; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009800:Oculocerebrorenal Syndrome / Q000378:metabolism; D014808:Vitamin D Deficiency / Q000378:metabolism
D001639:Bicarbonates; D002116:Calcitonin