Microsomal biphenyl 2-hydroxylation in the presence of some carcinogenic alkylaryltriazenes.
A hepatic mixed-function oxygenase system gave enhanced biphenyl 2-hydroxylation in the presence of known carcinogens in vitro and was therefore suggested as a convenient short-term assay for the detection of potentially dangerous compounds. However, the test did not yield the expected increase of biphenyl 2-hydroxylation with any of 8 selected carcinogenic triazenes. The new data are discussed in relation to the original supposition and to the hydroxylation pattern of various triazene substrates in vivo.
D000818:Animals; D001681:Biological Assay; D001713:Biphenyl Compounds; D002273:Carcinogens; D006900:Hydroxylation; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D051381:Rats; D014226:Triazenes / Q000633:toxicity*
D001713:Biphenyl Compounds; D002273:Carcinogens; D014226:Triazenes; D006899:Mixed Function Oxygenases