[Amenorrhoea and hyperprolactinaemia (author's transl)].
Prolactin was determined by radioimmunoassay in the serum of 112 patients with primary or secondary amenorrhoea. 21 cases showed hyperprolactinaemia with levels above 25 ng/ml (18.7%). 10 patients with levels between 25 and 50 ng/ml showed heterogeneous clinical features. In nine women (8%) the prolactin level was above 100 ng/ml; they all had severe amenorrhoea. As a result of treatment with bromocriptine menstrual bleeding occurred in 4 out of 7 cases and 2 of these patients became pregnant. In 3 cases prolactin did not return to normal levels and in 2 out of these patients microadenomas of the pituitary gland were diagnosed by special methods. They were removed surgically by the transsphenoidal approach.
D000236:Adenoma / Q000150:complications; D000293:Adolescent; D000328:Adult; D001971:Bromocriptine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008599:Menstruation Disturbances / Q000188:drug therapy*; D010911:Pituitary Neoplasms / Q000150:complications / Q000601:surgery; D011388:Prolactin / Q000097:blood*
D001971:Bromocriptine; D011388:Prolactin
Amenorrhö und Hyperprolaktinämie.