[Changes in somatotropic and lactotropic functions of the adenohypophysis of rats with acute alloxan diabetes].
Increased growth hormone and prolactin contents of the rat adenohypophysis during the development of experimental diabetes were found by colorimetric studies of stained electrophoregrams. 4 to 5 days after alloxan administration the levels of somatotropic hormone (STH) and prolactin were higher in comparison to those in intact animals by 58% and 43%, respectively. Experiments on the primary cell culture using the precursor 14C-L-leucine revealed an enhanced secretion of somatotropic hormone and prolactin by cells of the rats with alloxan diabetes. A possible role of the adenohypophyseal changes in the development of experimental diabetes is discussed.
D000818:Animals; D002478:Cells, Cultured; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D005260:Female; D013006:Growth Hormone / Q000096:biosynthesis / Q000378:metabolism*; D007930:Leucine / Q000378:metabolism; D010903:Pituitary Gland, Anterior / Q000378:metabolism*; D011388:Prolactin / Q000096:biosynthesis / Q000378:metabolism*; D051381:Rats
D011388:Prolactin; D013006:Growth Hormone; D007930:Leucine
Izmenenie somatotropnoĭ i laktotropnoĭ funktsiĭ adenogipofiza u krys s ostrym alloksanovym Diabetom.