[Role of adrenergic innervation in the regulation of the secretory activity of supraoptic nucleus cells in rats].
6-hydroxydopamine (6-HD), producing specific destruction of noradrenergic (NA) terminals, was used to study the role of NA innervation in the production of peptide neurohormones by the supraoptic nucleus (SON) cells. Seven days after intraventricular administration of 6-HD in a dose of 250 micrograms the fluorescence intensity of NA terminals in SON area was highly decreased and morphological pictures, reflecting the activation of hormone production in SON cells, were observed. According to the data obtained NA innervation is likely to inhibit the peptide neurohormone synthesis by SON cells and to regulate the transport and release of peptide neurohormones from the posterior pituitary into general circulation.
D000818:Animals; D006892:Hydroxydopamines / Q000494:pharmacology*; D007031:Hypothalamus / Q000502:physiology*; D008297:Male; D008856:Microscopy, Fluorescence; D009638:Norepinephrine / Q000502:physiology*; D051381:Rats; D013495:Supraoptic Nucleus / Q000187:drug effects / Q000502:physiology*
D006892:Hydroxydopamines; D009638:Norepinephrine
Rol' adrenergicheskoi innervatsii v reguliatsii sekretornoĭ aktivnosti kletok supraopticheskogo iadra u krys.