Suppressant effects of naltrexone on water intake in rats.
Parenteral administration of naltrexone to water-deprived female rats suppressed water intake when injected 4, but not 12 hours prior to the drinking session. Intraperitoneal injection 5 mg/kg naltrexone twice daily or oral self-administration of naltrexone in doses sufficient to block morphine-induced analgesia failed to reduce water intake or to alter body weight in non-deprived animals. These findings suggest that the suppressant effects of naltrexone on appetitive behavior are mediated by a different population of opiate receptors than those mediating morphine-induced analgesia.
D000818:Animals; D001835:Body Weight; D003864:Depression, Chemical; D004327:Drinking Behavior / Q000187:drug effects*; D005260:Female; D009270:Naloxone / Q000031:analogs & derivatives*; D009271:Naltrexone / Q000008:administration & dosage / Q000494:pharmacology*; D010146:Pain / Q000503:physiopathology; D011803:Quinine / Q000494:pharmacology; D051381:Rats; D012646:Self Administration; D012684:Sensory Thresholds / Q000187:drug effects; D013997:Time Factors; D014868:Water Deprivation
D009270:Naloxone; D009271:Naltrexone; D011803:Quinine