The systemic absorption from the vagina of prostaglandin E2 administered for the induction of labour.
The absorption rates of PGE2 released from tablets, gel and pessary bases inserted into the vagina for the induction of labour in a total of 27 patients have been measured by means of serial plasma 15-keto-PGE2 levels. The results are discussed with a view to obtaining both the optimum dose of PGE2 and vehicle of release.
D000042:Absorption; D005260:Female; D006801:Humans; D007751:Labor, Induced; D011247:Pregnancy; D011458:Prostaglandins E / Q000008:administration & dosage / Q000097:blood* / Q000627:therapeutic use; D014621:Vagina / Q000378:metabolism*
D011458:Prostaglandins E