[Action of naloxone on emotionally positive and antinociceptive effects of hypothalamic stimulation in rats].
Naloxone (5 mg/kg subcutaneously) failed to effect significantly the reaction of electric self-stimulation in rats with electrodes implanted into lateral hypothalamic area. In 3 rats the analgesic effect manifested in an increase of the threshold of painful vocalization under electrostimulation of the tail was revealed. The antinociceptive effect was abolished with naloxone. Morphine (3 mg/kg) potentiated self-stimulation while naloxone antagonized this action. The role of opiate receptors in effects of self-stimulation and centrally produced analgesia is discussed.
D000818:Animals; D004558:Electric Stimulation; D008297:Male; D009020:Morphine / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology*; D010146:Pain / Q000503:physiopathology*; D051381:Rats; D012653:Self Stimulation / Q000187:drug effects*
D009270:Naloxone; D009020:Morphine
Deĭstvie naloksona na emotsional'no-pozitivnye i antinotsitseptivnye effekty stimuliatsii gipotalamusa u krys.