Crystalluria during flucytosine therapy.
A case of urinary crystalluria occurring in a patient during treatment with flucytosine (5-fluorocytosine) is presented. A reduction in the dosage of the 5-fluorocytosine resulted in a marked decrease in the excretion of urinary gravel which was shown to be a coprecipitate of 5-fluorocytosine and uric acid.
D003453:Cryptococcosis / Q000188:drug therapy / Q000652:urine*; D003460:Crystallization; D003596:Cytosine / Q000031:analogs & derivatives*; D005437:Flucytosine / Q000627:therapeutic use* / Q000652:urine*; D006801:Humans; D008172:Lung Diseases, Fungal / Q000188:drug therapy / Q000652:urine*; D008297:Male; D008875:Middle Aged; D014527:Uric Acid / Q000652:urine*
D014527:Uric Acid; D003596:Cytosine; D005437:Flucytosine