Embryotoxicity of inhaled benzene in mice and rabbits.
The effect of inhaled benzene on embryonal and fetal development was assessed in mice and rabbits. CF-1 mice and New Zealand white rabbits were exposed to 0 or 500 ppm of benzene for 7 hr per day from days 6 through 15 (mice) and 6 through 18 (rabbits) of gestation. Little evidence of maternal toxicity was seen in either species. Although some signs of embryonal toxicity were observed in both mice and rabbits, a teratogenic effect was not discerned in either species inhaling 500 ppm of benzene.
D000336:Aerosols; D000818:Animals; D001554:Benzene / Q000494:pharmacology*; D001842:Bone and Bones / Q000473:pathology; D004353:Drug Evaluation, Preclinical; D005260:Female; D005313:Fetal Death; D008098:Litter Size; D051379:Mice / Q000196:embryology*; D011247:Pregnancy; D011817:Rabbits / Q000196:embryology*; D013045:Species Specificity; D013723:Teratogens
D000336:Aerosols; D013723:Teratogens; D001554:Benzene