[Regeneration of the proximal kidney tubules after sublimate-induced necrosis in the rate. Scanning electron microscopic studies].
Necrosis of the proximal tubules of the kidney in white rats has been produced by a relative small doses (1,5 mg/kg) of sublimate. Necrosis of the epithelial cells and their regeneration was studied during 10 days by scanning electron microscopy. Parallelism of the various regressive and regenerative processes was noted, attention was paid to the correlation existing between them. Periodicity of normal and necrotic segments was also observed. As a sequal of the necrosis the basement membranes became denuded, later in the first period of the regeneration flattened epithelial cells--having no microvilluses--covered them. On the surface of the latter, in a very short period (several hours) gradually microvilluses, regular brush-border and interdigitation of the cells were formed. In 10-17 days the regenerated epithelium could hardly be distinguished by scanning electron microscopy from the normal one.
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000818:Animals; D002712:Chlorides / Q000633:toxicity; D007683:Kidney Tubular Necrosis, Acute / Q000139:chemically induced*; D007687:Kidney Tubules, Proximal / Q000187:drug effects / Q000648:ultrastructure; D008627:Mercuric Chloride; D008628:Mercury / Q000633:toxicity*; D051381:Rats; D012038:Regeneration
D002712:Chlorides; D008627:Mercuric Chloride; D008628:Mercury
A proximális csatornák szublimátnekrózist követo regenerációja patkányvesében. Scanning elektron-mikroszkópos vizsgálatok.