title: Acute toxicity of a mercapto - functional silicone oil.
abstract: A poly(dimethylsiloxane) type silicone oil containing gamma-mercaptopropyl groups was evaluated for acute toxicity. Acute inhalation, oral and dermal toxicity, primary skin irritation, skin sensitization, eye irritation and human patch testing studies failed to demonstrate any significant response to this functional oil. Transient eye irritation and barely perceptible skin irritation were among the observations. On the basis of the data presented, it is doubtful that any problems of acute toxicity will result from the use of this silicone oil.
mesh_terms: D000284:Administration, Oral; D000287:Administration, Topical; D000818:Animals; D004129:Dimethylpolysiloxanes / Q000633:toxicity*; D005123:Eye / Q000187:drug effects; D005740:Gases / Q000032:analysis; D007509:Irritants; D007928:Lethal Dose 50; D008297:Male; D009821:Oils; D051381:Rats; D012828:Silicones / Q000633:toxicity*; D012867:Skin / Q000187:drug effects; D012882:Skin Tests
chemical_list: D004129:Dimethylpolysiloxanes; D005740:Gases; D007509:Irritants; D009821:Oils; D012828:Silicones