Malignant gliomas treated after surgery by combination chemotherapy and delayed radiation therapy. Part II. Tolerance to irradiation after chemotherapy.
34 patients operated on for malignant gliomas were successively treated by combination chemotherapy with VM26 and CCNU and conventional radiation therapy with an average dosage of 5,800 Rads, six months after surgery. The general and haematological tolerance of delayed irradiation after chemotherapy was satisfactory. Twelve patients developed neurological complications during or after irradiation. The complications were early in 10 cases, and delayed in 2. They were probably due to tumour growth in five cases, and secondary to irradiation in seven. In four of the seven cases the preradiation chemotherapy seemed to potentiate the radiation effect on the central nervous system.
D001921:Brain / Q000528:radiation effects*; D001932:Brain Neoplasms / Q000628:therapy*; D004359:Drug Therapy, Combination; D005910:Glioma / Q000628:therapy*; D006801:Humans; D008130:Lomustine / Q000008:administration & dosage / Q000009:adverse effects*; D009364:Neoplasm Recurrence, Local; D009607:Nitrosourea Compounds / Q000009:adverse effects*; D011034:Podophyllotoxin / Q000031:analogs & derivatives*; D011836:Radiation Tolerance; D011878:Radiotherapy / Q000009:adverse effects*; D011879:Radiotherapy Dosage; D013713:Teniposide / Q000008:administration & dosage / Q000009:adverse effects*
D009607:Nitrosourea Compounds; D008130:Lomustine; D013713:Teniposide; D011034:Podophyllotoxin