X-ray or gamma-ray leukemogenesis in mouse.
A theoretical model is given for leukemogenesis in mouse by X-Ray or gamma-Ray. The first step is a double strand break in the viral part of the genome which leads to constitutive production of the viral protein responsible for transformation by derepression of its operator control region. The second step is binding of viral protein to the regulator gene of a two repressor system in which binding to the regulator gene of the first repressor leads to synthesis of the second which will repress the expression of the leukocyte maturation gene. Results are compared with the experimental results of Major and Mole on CBA mice. The agreement is good.
D000818:Animals; D005720:Gamma Rays; D005809:Genes, Regulator; D005814:Genes, Viral; D007942:Leukemia, Experimental / Q000209:etiology*; D007953:Leukemia, Radiation-Induced / Q000209:etiology*; D051379:Mice; D008808:Mice, Inbred CBA; D008954:Models, Biological; D012190:Retroviridae; D014764:Viral Proteins; D014965:X-Rays
D014764:Viral Proteins