Metabolic and EEG alterations during the early phase of triethyltinsulphate (TET) intoxication.
EEG changes as well as the mechanisms of the hyperglycaemic effect of triethyltinsulphate (TET), a compound known to induce brain oedema, were investigated in cats and rabbits, respectively. Considerable EEG alterations characterized by slow waves appeared in some minutes after TET administration. The hyperglycaemic effect of TET like that of epinephrine could be prevented by the administration of 1 mg/kg of the beta blocker, pindolol. It is suggested that the hyperglycaemic effect of TET is brought about by sympathetic activation.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001929:Brain Edema / Q000139:chemically induced; D002415:Cats; D002540:Cerebral Cortex / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D006943:Hyperglycemia / Q000139:chemically induced*; D008297:Male; D014220:Trialkyltin Compounds / Q000633:toxicity*; D014267:Triethyltin Compounds / Q000633:toxicity*
D001786:Blood Glucose; D014220:Trialkyltin Compounds; D014267:Triethyltin Compounds; D004837:Epinephrine