title: Modification of motor activity, passive avoidance conditioning and evoked potentials by microinjections of picrotoxin in both caudate nuclei in cats.
abstract: Inhibition of movements is the result of the caudate nucleus (CN) activity. This action seems to be necessary for passive avoidance conditioning (PAC). Much data indicates that GABA has inhibitory effects in the CN. The present report provides further evidence for GABA inhibition in th4 CN. In cats, the acquisition session of a PAC response was carried out following the bilateral administration of 6 microgram of picrotoxin or saline in the CN. Twenty four hours later (1st test session) the animals were placed in the security compartment and remained there during 600 sec. In the second test, the cats injected with picrotoxin crossed to the other compartment while the subjects injected with saline did not move. Another series of acute experiments were also carried out. Evoked potentials (EP) were recorded in the CN produced by nucleus centralis medialis electrical stimulation. After picrotoxin application the first and second peaks, which could represent EPSPs, incraeased while the third peak, which could represent IPSPs, decreased. In conclusion, it seems that GABAergic intracaudate transmission maintains a lower level of neuronal discharges and probably participates in the maintenance of a PAC but not in its acquisition.
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D002415:Cats; D002421:Caudate Nucleus / Q000502:physiology*; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D008297:Male; D008845:Microinjections; D009043:Motor Activity / Q000187:drug effects*; D010852:Picrotoxin / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D010852:Picrotoxin