Mode of hypocholesterolemic action of S-methylmethionine (vitamin U) in mice.
S-Methylmethionine (vitamin U) markedly increased the fecal excretion of both 14C-bile acids and 14C-neutral sterols in 14C-cholesterol injected mice, and did not inhibit both intestinal absorption of 14C-cholesterol and biosynthesis of 14C-cholesterol from 14C-acetate in mice.
D000085:Acetates / Q000378:metabolism; D000818:Animals; D000924:Anticholesteremic Agents; D001647:Bile Acids and Salts / Q000378:metabolism; D002784:Cholesterol / Q000096:biosynthesis / Q000378:metabolism; D005243:Feces / Q000032:analysis; D007408:Intestinal Absorption; D051379:Mice; D008813:Mice, Inbred ICR; D013261:Sterols / Q000378:metabolism; D014814:Vitamin U / Q000494:pharmacology*; D014815:Vitamins / Q000494:pharmacology*
D000085:Acetates; D000924:Anticholesteremic Agents; D001647:Bile Acids and Salts; D013261:Sterols; D014815:Vitamins; D014814:Vitamin U; D002784:Cholesterol