Indomethacin-induced inhibition of haversian remodelling in rabbits.
The effect of indomethacin on haversian remodelling in the radius was studied in 16 rabbits. An osteotomy and a saw-cut almost through the bone were made in the middle and distal parts of the right radius, respectively. In order to obtain biological osteosynthesis in the osteotomy and the saw-cut the rabbits were not treated in any way during the following 3 weeks. They were then given either indomethacin or placebo suspensions per os, 10 mg/kg/day for 2 weeks, followed by 5 mg/kg/day for 4 weeks. The extent of haversian remodelling was estimated by calcein and oxytetracycline fluorochrome labels given at the start of the indomethacin treatment and 3 weeks later, respectively. After 2 weeks of indomethacin treatment (10 mg/kg/day) the indomethacin plasma levels were about 0.18 microgram/ml 24 hours after the last dose. Indomethacin treatment significantly (2P less than 0.019) inhibited haversian remodelling as estimated by fluorochrome labelling.
D000818:Animals; D001842:Bone and Bones / Q000601:surgery*; D005260:Female; D006253:Haversian System / Q000502:physiology*; D007213:Indomethacin / Q000097:blood / Q000494:pharmacology*; D008856:Microscopy, Fluorescence; D010027:Osteotomy; D011817:Rabbits; D011884:Radius / Q000473:pathology / Q000502:physiology; D014457:Ulna / Q000473:pathology / Q000502:physiology; D014945:Wound Healing / Q000187:drug effects*
D007213:Indomethacin