Potential antiinflammatory compounds. 2. Acidic antiinflammatory 1,2-benzisoxazoles.
A number of 1,2-benzisoxazoles, substituted in the 3 position with 4-substituted phenyl groups and in the 5--7 positions with acetic and propionic acid residues, have been synthesized and tested in the rat carrageenan foot edema assay. Activity has been found in the 6- and 7-substituted acids.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis*; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000503:physiopathology; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D010080:Oxazoles / Q000138:chemical synthesis*; D051381:Rats; D013329:Structure-Activity Relationship
D000893:Anti-Inflammatory Agents; D007555:Isoxazoles; D010080:Oxazoles; D002351:Carrageenan