title: Bladder calculi in rats treated with nitrosomethylurea and fed artificial sweeteners.
abstract: Female Wistar rats treated once with nitrosomethylurea (NMU) by urinary bladder instillation were given saccharin, cyclamate or calcium carbonate in the diet for life. X-ray examinations were performed every three weeks to detect early formations of urinary bladder calculi, while an intravenous pyelogram and cystography served as a method for detection of neoplastic alterations. No statistical correlation could be established between the occurrence of urinary bladder stones and neoplasma in the various groups.
mesh_terms: D000818:Animals; D002119:Calcium Carbonate; D003494:Cyclamates; D005260:Female; D008770:Methylnitrosourea; D011859:Radiography; D051381:Rats; D012439:Saccharin; D001744:Urinary Bladder Calculi / Q000139:chemically induced / Q000000981:diagnostic imaging*
chemical_list: D003494:Cyclamates; D008770:Methylnitrosourea; D012439:Saccharin; D002119:Calcium Carbonate