Succinate dehydrogenase activity in rat kidney after repeated administrations of p-aminohippurate or sodium chloride.
During PAH excretion and 18 h after repeated PAH administrations to rats, renal cortical SDH activity was unchanged in comparison with untreated controls. On the other hand, 18 h after repeated administrations of 0.9% or 1.8% NaCl solution, SDH activity was decreased by about 20% in kidney cortex. In outer medulla SDH activity was decreased 18 h after all pretreatments. The decline of SDH activity was observed whenever an increased urinary Na excretion occurred, except that PAH was repeatedly administered. The probability is discussed that substrate-induced stimulation of the carrier system for weak organic acids is accompanied by an increase of mitochondrial activity in kidney cortex.
D000618:Aminohippuric Acids / Q000494:pharmacology*; D000818:Animals; D005260:Female; D007668:Kidney / Q000187:drug effects / Q000201:enzymology*; D007672:Kidney Cortex / Q000201:enzymology; D007679:Kidney Medulla / Q000187:drug effects; D011188:Potassium / Q000378:metabolism; D051381:Rats; D012964:Sodium / Q000378:metabolism; D012965:Sodium Chloride / Q000494:pharmacology*; D013385:Succinate Dehydrogenase / Q000378:metabolism*; D010130:p-Aminohippuric Acid / Q000494:pharmacology*
D000618:Aminohippuric Acids; D012965:Sodium Chloride; D012964:Sodium; D013385:Succinate Dehydrogenase; D011188:Potassium; D010130:p-Aminohippuric Acid