Structural changes in parathyroid glands exposed to vitamin D metabolites in vitro.
Isolated parathyroid glands from normal adult Mongolian gerbils were incubated for 10 minutes to 16 1/2 hours at high, medium or low concentrations of Ca2+, with or without added 1,25-dihydroxycholecalciferol (1.25-DHCC) or 25-hydroxycholecalciferol (25-HCC), after which they were studied electron microscopically. 1,25-DHCC appeared to potentiate the inhibitory action of high calcium on parathyroid activity, whereas 25-HCC had no structurally detectable effect.
D000818:Animals; D002118:Calcium / Q000494:pharmacology; D004100:Dihydroxycholecalciferols / Q000494:pharmacology; D005260:Female; D005849:Gerbillinae; D006887:Hydroxycholecalciferols / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D008854:Microscopy, Electron; D010280:Parathyroid Glands / Q000166:cytology / Q000187:drug effects* / Q000648:ultrastructure; D013997:Time Factors
D004100:Dihydroxycholecalciferols; D006887:Hydroxycholecalciferols; D002118:Calcium