title: [Anti-inflammatory action of extracts from marine algae collected in the area of Burgas seacoast].
abstract: It was established by a series of experiments with white Wistar rats that intraperitoneal injection of water extracts (infusions) of a mixed sample of dried algae (Cystosira barbata, Ulva lactica and Zostera nona) collected at the Bourgas coastal region, respectively leveled to an isotonic solution by use of 0.9% NaCl produces well expressed antiinflammatory effect in Caragina provoked oedema. The mixed sample of algae has LD0--0.250 g dry drug per kg body weight, LD'100--0.500 g/kg b. w. and LD50--0.407 g/kg b. w. The therapeutic index of the algae is relatively high -- LD50/U50+20.
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents; D002031:Bulgaria; D002351:Carrageenan / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D056890:Eukaryota; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy*; D007928:Lethal Dose 50; D008297:Male; D008386:Marine Biology; D010936:Plant Extracts / Q000627:therapeutic use* / Q000633:toxicity; D051381:Rats
chemical_list: D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D002351:Carrageenan
vernacular_title: Protivovuzpalitelno deĭstvie na ekstrakti ot morski vodorasli, subrani v raĭona na Burgaskoto kraĭbrezhie.