[Beta-receptor blocking drugs and the bronchial system. A comparative study of pindolol and metoprolol (author's transl)].
Effects of the beta 2-receptor stimulating drug fenoterol were investigated after administration of beta-receptor blocking agents in 12 patients with obstructive respiratory disease and a hyperreactive bronchial system (positive acetylcholine test). In a double blind trial pindolol (universal beta-receptor blocking drug) and metoprolol (a cardioselective substance) were compared after administration of equally effective doses of 5 and 100 mg respectively. Whole-body plethysmography showed that both beta-receptor blocking drugs caused no bronchial constriction; the bronchodilating effects of fenoterol were not reduced. These findings must cast doubt on the differentiation between cardioselective and non-cardioselective beta-receptor blocking agents as far as practical therapeutic implications are concerned.
D001991:Bronchitis / Q000188:drug therapy*; D005260:Female; D005280:Fenoterol / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008790:Metoprolol / Q000627:therapeutic use*; D008875:Middle Aged; D010869:Pindolol / Q000627:therapeutic use*; D010993:Plethysmography, Whole Body; D011412:Propanolamines / Q000627:therapeutic use*
D011412:Propanolamines; D005280:Fenoterol; D010869:Pindolol; D008790:Metoprolol
Beta-Rezeptorenblocker und Bronchialsystem. Eine Vergleichsstudie mit Pindolol und Metroprolol.