title: Possible psychopharmacological agents. Part 7: Synthesis and CNS activity of some fluorinated 2,4,7/8-trisubstituted-3H-1,5-benzodiazepinium monoperchlorates.
abstract: A series of new fluorinated 2,4'7/8-trisubstituted-3H-1,5-benzodiazepinium monoperchlorates have been synthesized and characterized by IR and NMR spectral studies. Representative compounds have been screened for their CNS activity viz., behavioural, analgesic, anticonvulsant and antireserpine. 8-Chloro-2-(4'-fluorophenyl)-4-phenyl-3H-1,5-benzodiazepinium monoperchlorate has shown pronounced antireserpine activity.
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis; D001522:Behavior, Animal / Q000187:drug effects; D001569:Benzodiazepines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D001831:Body Temperature / Q000187:drug effects; D007928:Lethal Dose 50; D051379:Mice; D011619:Psychotropic Drugs / Q000138:chemical synthesis* / Q000633:toxicity; D012110:Reserpine / Q000037:antagonists & inhibitors
chemical_list: D000700:Analgesics; D000927:Anticonvulsants; D011619:Psychotropic Drugs; D001569:Benzodiazepines; D012110:Reserpine