Virus-like particles induced by bromodeoxyuridine in melanoma and neuroblastoma of Xiphophorus.
5-Bromodeoxyuridine (BrdUrd) injected into the muscular tissue of fish bearing melanoma or neuroblastoma induces the production of virus-like particles in these tumors. The particles in the melanoma are morphologically similar to papovaviruses of polyoma-type, those in the neuroblastoma resemble oncornaviruses of B- and C-type.
D000818:Animals; D001973:Bromodeoxyuridine / Q000494:pharmacology*; D005393:Fish Diseases / Q000382:microbiology*; D005399:Fishes; D007181:Inclusion Bodies, Viral / Q000187:drug effects*; D008545:Melanoma / Q000382:microbiology / Q000648:ultrastructure / Q000662:veterinary*; D008854:Microscopy, Electron; D009447:Neuroblastoma / Q000382:microbiology / Q000648:ultrastructure / Q000662:veterinary*
D001973:Bromodeoxyuridine