title: [Combined chemotherapy of herpes simplex infections of the skin].
abstract: It was possible to prolong the herpes free intervals with combined chemotherapy with 0,3% Ethyl-desoxyuridine (EDU)-Gel during the acute phase and continued application of 0,2% Jodo-desoxyuridine (IDU)-ointment with 1,8% DMSO. The combined chemotherapy did not improve the effect of the treatment with EDU alone in respect of the duration of skin lesions. In 5 out of 8 patients with recurrent cold sores and in 3 out of 10 patients with genital herpes further immunotherapeutical measures were not necessary. The results indicate that beside the chemotherapy of the recurrences with monotherapy a continuous chemoprophylaxis can be successful in patients with recurrent herpes simplex.
mesh_terms: D000328:Adult; D003857:Deoxyuridine / Q000008:administration & dosage; D004121:Dimethyl Sulfoxide / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005260:Female; D005782:Gels; D005832:Genital Diseases, Male / Q000188:drug therapy; D006560:Herpes Labialis / Q000188:drug therapy; D006561:Herpes Simplex / Q000188:drug therapy*; D006801:Humans; D008297:Male; D009824:Ointments; D012008:Recurrence; D012874:Skin Diseases, Infectious / Q000188:drug therapy*
chemical_list: D005782:Gels; D009824:Ointments; D003857:Deoxyuridine; D004121:Dimethyl Sulfoxide
vernacular_title: Kombinierte Chemotherapie bei Herpes-simplex-Infektionen der Haut.