[Pharmacokinetics of the pressor substance, 5,8-dimethoxy-trans-2-(2-hydroxyethyl)-amino-3-hydroxy-1,2,3,4-tetrahydronaphthalene hydrochloride (1b), after intravenous use].
The authors investigated the pharmacokinetics of the pressor substance 5,8-dimetoxy-trans-2-/2-hydroxyethyl/-amino-3-hydroxy-1,2,3,4-tetrahydronaphthaline hydrochloride (1b), which possessed strong pressor action. Blood concentrations after venous administration in a dose of 1 mg/kg of body weight were determined by means of exctration spectrofluorometric method. The data complied with the biexponential equation, meeting the requirements of an open two-compartment model. There was a quick elimination of the substance from the central compartment, which correlated also with the data for quick disappearances of the effect on the arterial pressure.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D009281:Naphthalenes / Q000097:blood*; D011817:Rabbits; D013764:Tetrahydronaphthalenes / Q000097:blood*; D013997:Time Factors; D014662:Vasoconstrictor Agents
D009281:Naphthalenes; D013764:Tetrahydronaphthalenes; D014662:Vasoconstrictor Agents
Farmakokinetika na presornoto veshtestvo 5,8-dimetoksi-trans-2-(2-khidroksietil)-amino-3-khidroksi-1,2,3,4-tetrakhidronaftalin khidrokhlorid (1b) sled intravenozno prilagane.