Hydrolysis of chylomicron triacylglycerol by endothelium-bound lipoprotein lipase. Effect of decreased apoprotein C-II/C-III ratio.
Chylomicrons with a decreased ratio of C-II/C-III apoproteins on their surface produced by the addition of apoproteins C-III-0 or C-III-3 to intact rat lymph chylomicrons. These chylomicrons inhibited the activity of soluble lipoprotein lipase in vitro, but had no effect on the activity of the endothelium-bound enzyme in the perfused heart.
D000818:Animals; D001059:Apoproteins / Q000378:metabolism / Q000494:pharmacology*; D002914:Chylomicrons / Q000378:metabolism*; D004591:Electrophoresis, Polyacrylamide Gel; D004727:Endothelium / Q000201:enzymology; D006868:Hydrolysis; D008071:Lipoprotein Lipase / Q000378:metabolism*; D008297:Male; D009206:Myocardium / Q000378:metabolism; D011485:Protein Binding; D051381:Rats; D014280:Triglycerides / Q000378:metabolism*
D001059:Apoproteins; D002914:Chylomicrons; D014280:Triglycerides; D008071:Lipoprotein Lipase