Asymmetry of optokinetic trace phenomena induced by unilateral 6-OHDA lesion of substantia nigra in the rabbit.
Prolonged (1 h) optokinetic nystagmus (OKN) is followed in darkness by reversed postoptokinetic nystagmus (RPN) lasting 20-30 min in intact rabbits. Unilateral 6-OHDA lesion (10 microgram/5 microliter) of left substantia nigra did not disturb symmetry of the OKN reactions to monocular stimulation of either eye but weakened RPN induced by stimulation of the right eye. This RPN asymmetry was unaffected by amphetamine (2.5 mg/kg) but was reversed by apomorphine (1 mg/kg). It is concluded that the nigrostriatal system contributes to the development of the neural trace underlying RPN.
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001931:Brain Mapping; D002682:Chinchilla; D003342:Corpus Striatum / Q000502:physiology; D004298:Dopamine / Q000502:physiology*; D005133:Eye Movements / Q000187:drug effects; D006892:Hydroxydopamines / Q000494:pharmacology; D009434:Neural Pathways / Q000502:physiology; D011817:Rabbits; D013378:Substantia Nigra / Q000502:physiology*
D006892:Hydroxydopamines; D000661:Amphetamine; D001058:Apomorphine; D004298:Dopamine