title: Problems of competition in charcoal hemoperfusion for the treatment of intoxications.
abstract: Both toxic and physiological substances are adsorbed during an extracorporeal hemoperfusion for the treatment of exogenous and endogenous intoxications. Using a closed circuit in vitro, we perfused one liter saline or fresh human plasma with 4425 mumol creatinine, 4854 mumol and 97,086 mumol barbital-Na, 597 mumol bromthalein, 1942 mumol and 29,126 mumol raffinose, and 200 mumol inulin in different combinations over 70 gm of uncoated charcoal with the following results: 1. The adsorptive capacity of other substances is not influenced by preadsorption of the charcoal with a low or middle molecular weight substance; 2. In the low and middle molecular weight range, there is no competition between two substances in a solution; 3. The simultaneous usage of two substances of middle and high molecular weight, or preadsorption with a high molecular weight substance, reduces the rate of adsorption and the capacity of charcoal for middle molecular weight substances, but not for low molecular weight substances.
mesh_terms: D000327:Adsorption; D001462:Barbital / Q000097:blood; D001667:Binding, Competitive; D002606:Charcoal; D003404:Creatinine / Q000097:blood; D006464:Hemoperfusion; D006801:Humans; D007444:Inulin / Q000097:blood; D011041:Poisoning / Q000628:therapy*; D011485:Protein Binding; D011887:Raffinose / Q000097:blood; D013448:Sulfobromophthalein; D013499:Surface Properties
chemical_list: D013448:Sulfobromophthalein; D002606:Charcoal; D001462:Barbital; D007444:Inulin; D003404:Creatinine; D011887:Raffinose