Identification of the active metabolites of the isoxazolylpenicillins by means of mass-spectrometry.
Electron-impact mass-spectrometry of the methyl esters of the isoxazolylpenicillins and of their active metabolites showed the latter to be formed from their parent compounds by hydroxylation of the 5-methyl group.
D000818:Animals; D001711:Biotransformation; D003023:Cloxacillin / Q000378:metabolism; D004009:Dicloxacillin / Q000378:metabolism; D005436:Floxacillin / Q000378:metabolism; D013058:Mass Spectrometry; D010068:Oxacillin / Q000378:metabolism; D010406:Penicillins / Q000378:metabolism* / Q000652:urine; D051381:Rats
D010406:Penicillins; D005436:Floxacillin; D004009:Dicloxacillin; D003023:Cloxacillin; D010068:Oxacillin