Synthesis of five new 99mTc-HIDA isomers and comparison with 99mTc-HIDA.
Five new HIDA-compounds were synthesized, labelled with 99mTc and compared with 99mTc-(2,6-dimethyl)HIDA viz. (N-2,6-dimethylphenylcarbamoylmethyl)iminodiacetic acid by means of TLC and biodistribution studies on rabbits. The computerized method used by Britton and Brown during renal studies was successfully adapted to study the biodistribution of these agents.
D000818:Animals; D003201:Computers; D007098:Imino Acids / Q000008:administration & dosage / Q000138:chemical synthesis / Q000378:metabolism*; D007700:Kinetics; D008099:Liver / Q000000981:diagnostic imaging*; D011817:Rabbits; D011877:Radionuclide Imaging; D013667:Technetium / Q000008:administration & dosage / Q000378:metabolism; D014018:Tissue Distribution
D007098:Imino Acids; D013667:Technetium