title: The effect of megadose ascorbate on some haemopoietic factors in the young guinea pig.
abstract: The effect of oral administration of megadoses of ascorbate was studied on some haemopoietic factors in young apparently normal guinea pigs. Supplementation of 150 mg of the vitamin for 7 days resulted in significantly increased haematocrit value and haemoglobin concentration. Total and unsaturated iron binding capacity were also increased in association with elevated plasma iron concentration. The difference of these results from the control animals, however, was not statistically significant. The improved haematological status in guinea pigs by ascorbate treatment could be attributed to haemoconcentration rather than to an effect of iron metabolism.
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D001798:Blood Proteins / Q000032:analysis; D001835:Body Weight / Q000187:drug effects; D004910:Erythrocyte Membrane / Q000187:drug effects; D006168:Guinea Pigs; D006400:Hematocrit; D006413:Hematopoietic System / Q000187:drug effects*; D006454:Hemoglobins / Q000032:analysis; D007501:Iron / Q000097:blood; D008297:Male; D009996:Osmotic Fragility / Q000187:drug effects
chemical_list: D001798:Blood Proteins; D006454:Hemoglobins; D007501:Iron; D001205:Ascorbic Acid