title: Granulocyte function during prophylaxis with doxycycline.
abstract: The influence of doxycycline on granulocyte migration was investigated on patients undergoing fracture surgery. The granulocyte migration of the patients was depressed when doxycycline was administered. Scanning electron microscopy demonstrated a decreased granulocyte adherence to glass as well as a decrease in number of filopods per cell in the presence of doxycycline.
mesh_terms: D002448:Cell Adhesion / Q000187:drug effects; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D004318:Doxycycline / Q000627:therapeutic use*; D006098:Granulocytes / Q000187:drug effects* / Q000276:immunology; D006801:Humans; D013530:Surgical Wound Infection / Q000517:prevention & control*
chemical_list: D004318:Doxycycline