[Existence of glucocorticoid-specific receptors in the plasma membranes of rat liver].
It was found that isolated plasma membranes whose purity was assayed by determinations of marker enzyme activities, specifically bind dexamethasone. The association constant and the number of binding sites were found to be equal to (7,03 +/- 4,05) . 10(9) M-1 and (1,6 +/- 0,18) . 10(-14) mol/mg protein, respectively. It was assumed that lipoprotein components of plasma membranes are involved in this binding.
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D003907:Dexamethasone / Q000378:metabolism; D007700:Kinetics; D008074:Lipoproteins / Q000032:analysis; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D011965:Receptors, Glucocorticoid / Q000378:metabolism*; D011987:Receptors, Steroid / Q000378:metabolism*
D008074:Lipoproteins; D011965:Receptors, Glucocorticoid; D011987:Receptors, Steroid; D003907:Dexamethasone
K voprosu o sushchestvovanii spetsificheskikh retseptorov k gliukokortikoidam na plazmaticheskikh membranakh pecheni krys.