Effectiveness of nafcillin, methicillin, and cephalothin in experimental Staphylococcus aureus endocarditis.
Nafcillin, methicillin, and cephalothin (40 mg/kg every 6 h) were all effective in reducing the number of Staphylococcus aureus in vegetations in rabbits with endocarditis. Nafcillin and methicillin reduced the number of S. aureus at a significantly faster rate than did cephalothin. Nafcillin and methicillin also reduced titers of the S. aureus more rapidly than did cephalothin in vitro, both in broth and in rabbit serum.
D000818:Animals; D002512:Cephalothin / Q000097:blood / Q000627:therapeutic use*; D004697:Endocarditis, Bacterial / Q000188:drug therapy*; D005260:Female; D008712:Methicillin / Q000097:blood / Q000627:therapeutic use*; D009254:Nafcillin / Q000097:blood / Q000627:therapeutic use*; D011817:Rabbits; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013997:Time Factors
D009254:Nafcillin; D008712:Methicillin; D002512:Cephalothin