RM values of naphthols and acetophenones in structure-activity studies.
The RM values of naphthols obtained in a chromatographic system where the stationary phase consisted of a silica gel G layer impregnated with silicone oil are much more closely related to the log P values in an octanol-water system than the RM values determined on polyamide layers. Similarly, the RM values of a series of acetophenones in the silicone system are closely related to their log P values. The equations describing the structure-activity relationship indicate the importance of lipophilic character and halogen substitution in determining the hemolytic activity and the acute toxicity of compounds.
D000098:Acetophenones / Q000032:analysis* / Q000494:pharmacology; D000818:Animals; D002855:Chromatography, Thin Layer / Q000379:methods; D006461:Hemolysis / Q000187:drug effects; D007928:Lethal Dose 50; D051379:Mice; D009284:Naphthols / Q000032:analysis* / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship
D000098:Acetophenones; D009284:Naphthols