title: Potassium toxicity and acid-base balance from large oral doses of potassium to young calves.
abstract: Potassium chloride and sodium chloride were infused into the reticulorumen of male Holstein calves, approximately 6 mo of age and 260 kg, at .29, .58, 1.15, 1.73, 2.31, or 2.88 g potassium per kilogram body weight or 1.35, 2.12, or 2.16 g sodium per kilogram in equal volumes of water. Paired controls were infused with water. Calves were monitored for physiological changes for 6 h at 15, 30, or 60-min intervals. Potassium and total solids of plasma and packed cell volume were increased at potassium doses greater than .29 g of potassium per kilogram body weight within 1 h after dosing. At the higher doses of potassium, sodium content of plasma increased about 1 h after the increase in plasma potassium. Respiration rates within a potassium treatment varied with respect to time after dosing, but generally they increased, and associated variables of carbon dioxide pressure, pH, and bicarbonate in blood were decreased accordingly. Clinical toxicity signs, including excess salivation, muscular tremors of legs, and excitability were observed with potassium doses greater than .58 g of potassium per kilogram body weight. Three of five calves given 1.73 g of potassium per kilogram, three of four calves given 2.31 g of potassium per kilogram, and one calf given 2.88 g of potassium per kilogram body weight died. With a small number of calves, oral sodium infusions increased plasma sodium in proportion to the dose, but plasma potassium remained relatively constant. Sodium infusions of 2.12 and 2.16 g of sodium per kilogram body weight were fatal.
mesh_terms: D000137:Acid-Base Imbalance / Q000139:chemically induced*; D000818:Animals; D001784:Blood Gas Analysis; D002417:Cattle / Q000378:metabolism*; D002418:Cattle Diseases / Q000139:chemically induced*; D006339:Heart Rate / Q000187:drug effects; D006400:Hematocrit; D007441:Intubation, Gastrointestinal; D008297:Male; D011188:Potassium / Q000009:adverse effects* / Q000097:blood; D011189:Potassium Chloride / Q000008:administration & dosage; D012119:Respiration / Q000187:drug effects; D012964:Sodium / Q000097:blood; D012965:Sodium Chloride / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D012965:Sodium Chloride; D011189:Potassium Chloride; D012964:Sodium; D011188:Potassium