title: Effect of some drugs on human appendix in vitro.
abstract: Muscarinic action of acetylcholine was demonstrated in the human isolated appendix. Histamine-induced contractions seemed to the mediated by H1 receptors. Nicotine and DMPP-induced contractions were mediated through their action on ganglion cells. Experiments with adrenergic drugs suggested the presence of beta receptors.
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D001065:Appendix / Q000187:drug effects*; D004246:Dimethylphenylpiperazinium Iodide / Q000494:pharmacology; D004347:Drug Interactions; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects; D012701:Serotonin / Q000494:pharmacology; D013566:Sympathomimetics / Q000494:pharmacology
chemical_list: D013566:Sympathomimetics; D012701:Serotonin; D004246:Dimethylphenylpiperazinium Iodide; D006632:Histamine; D000109:Acetylcholine