The fate of ticlopidine in the organism. II.--Distribution and elimination of ticlopidine 14C after a single oral administration in the rat.
In the Rat, distribution and elimination of Ticlopidine C14 after a single oral dose of 25 mg/kg were studied and compared with that observed after a single intravenous injection of the same dose. The plasma decreases of total radioactivity were found to be identical regardless of adminstration route, indicating almost complete absorption of the labelled molecule. The elimination half-life, which was 1.56 +/- 0.08 days, was equivalent to the half-life measured after intravenous injection, and no difference in tissues distribution was observed. As in the case of intravenous injection, the radioactivity was eliminated principally in the feces and only to a slight degree in the urine.
D000284:Administration, Oral; D000818:Animals; D005243:Feces / Q000032:analysis; D007408:Intestinal Absorption; D011725:Pyridines / Q000008:administration & dosage / Q000378:metabolism*; D051381:Rats; D013876:Thiophenes / Q000008:administration & dosage / Q000378:metabolism*; D013997:Time Factors; D014018:Tissue Distribution
D011725:Pyridines; D013876:Thiophenes