The influence of prostaglandins E2 and F2 alpha on electrotropic and inotropic vagal effects on the isolated rabbit atrium.
1. PG E2 (2.10(-8) g/ml) produces a positive inotropic effect and lengthens the duration of the action potential at the level of 50% and 90% of repolarization. 2. PG F2 alpha acts negatively inotropic and shortens the action potential at the level of 75% and 90% of repolarization. 3. PG F2 alpha (2.10(-8) g/ml) increases both the electrotropic and inotropic vagal effects, PG E2 (2.10(-8) g/ml) decreases them. 4. PG E2 improves the electromechanical coupling, PG F2 alpha reduces it.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D016275:Atrial Function; D006325:Heart Atria / Q000187:drug effects; D008433:Mathematics; D008954:Models, Biological; D009200:Myocardial Contraction / Q000187:drug effects*; D011458:Prostaglandins E / Q000494:pharmacology*; D011460:Prostaglandins F / Q000494:pharmacology*; D011817:Rabbits; D014630:Vagus Nerve / Q000187:drug effects / Q000502:physiology*
D011458:Prostaglandins E; D011460:Prostaglandins F