Effect of hyperthermia alone and in combination with 60Co radiation on the growth of B16 melanoma in mice.
B16 melanoma was grown in the tail of B6D2F1/BOM mice. Procedures for simultaneous local 60Co irradiation and heat treatment are described. A dose of 4 Gy had no effect on tumour growth; heat treatment at 41.5 degrees C for 200 min had a minor effect, while the combined treatment caused a marked delay in tumor growth. Heat treatment of tumours in the thigh at 41.5 degrees C for 2 hours did not influence the frequency of lung metastases.
D000818:Animals; D002460:Cell Line; D003037:Cobalt Radioisotopes / Q000627:therapeutic use*; D005260:Female; D006358:Hot Temperature / Q000627:therapeutic use*; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D008545:Melanoma / Q000532:radiotherapy / Q000628:therapy*; D051379:Mice; D008815:Mice, Inbred Strains; D009362:Neoplasm Metastasis / Q000517:prevention & control; D009374:Neoplasms, Experimental / Q000532:radiotherapy / Q000628:therapy
D003037:Cobalt Radioisotopes