[Comparative investigations on the organotropic carcinogenic effect of different N-nitroso compounds with rat after single and chronic treatment (author's transl)].
After the gavage of 200 mg N-nitrosodiethylamine per kg body weight only kidney tumors developed while long-term administration of 10 ppm N-nitrosodiethylamine induced esophageal tumors and hepatocellular carcinomas in female rats (SIV 50). This change of the organ-specific carcinogenic effect is not observed in experiments with N-methyl-N-nitrosobenzylamines substituted with a methyl group at the phenyl moiety. Both chronic treatment and single doses induced tumors of the esophagus and the pharynx.
D000818:Animals; D001593:Benzyl Compounds / Q000633:toxicity; D004052:Diethylnitrosamine / Q000633:toxicity; D004128:Dimethylnitrosamine / Q000031:analogs & derivatives* / Q000633:toxicity; D004938:Esophageal Neoplasms / Q000139:chemically induced; D005260:Female; D007680:Kidney Neoplasms / Q000139:chemically induced; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D009928:Organ Specificity; D010610:Pharyngeal Neoplasms / Q000139:chemically induced; D051381:Rats; D013997:Time Factors
D001593:Benzyl Compounds; D004052:Diethylnitrosamine; C014707:nitrosobenzylmethylamine; D004128:Dimethylnitrosamine
Vergleichende Untersuchungen über die organotrope carcinogene Wirkung verschiedener N-Nitrosoverbindungen nach einmaliger bzw. langzeitiger Applikation bei Ratten.