[Changes in serum levels of antibiotics in experimental CCL4 poisoning. I. Gentamycin].
The AA. studied gentamycin serum levels (1mg/Kg b.w.) in rats. The 50% of the animals studied where treated with CCl4 (1 ml/Kg b;w.) 24h previously, the remaining 50% recieved a placebo. The maximum serum levels where similar in both groups; but the antibiotic was removed more slowly (120-240min) in the groups which recieved CCl4. The slower rimotion rate causes more serious histological changes in the kidney.
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000097:blood / Q000378:metabolism* / Q000473:pathology; D005839:Gentamicins / Q000097:blood* / Q000378:metabolism; D007668:Kidney / Q000473:pathology; D051381:Rats
D005839:Gentamicins
Variazioni dei livelli sierici di antibiotici nella intossicazione sperimentale da CCl4. i. Gentamicina.