Effect of N,N'-bis(methylisatin-beta-thiosemicarbazone)-2-methylpiperazine on vaccinia virus replication in vitro and in vivo. Brief report.
The inhibitory effect of N,N'-bis(methylisatin-beta-thiosemicarbazone)-2-methylpiperazine (compound TSKI-VI) and methisazone (Marboran) on the growth of vaccinia virus (IHD strain) was studied in vitro and in vivo. The therapeutic indices of both compounds determined in vivo were similar, but TSKI-VI was found more efficient in vitro.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D002642:Chick Embryo; D046508:Culture Techniques; D005260:Female; D005347:Fibroblasts; D008297:Male; D008720:Methisazone / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D051379:Mice; D010879:Piperazines / Q000494:pharmacology* / Q000633:toxicity; D013882:Thiosemicarbazones / Q000494:pharmacology* / Q000627:therapeutic use; D014615:Vaccinia / Q000517:prevention & control; D014616:Vaccinia virus / Q000187:drug effects* / Q000254:growth & development; D014779:Virus Replication / Q000187:drug effects*
D010879:Piperazines; D013882:Thiosemicarbazones; C023484:TSKI-VI; D008720:Methisazone