GLC determination of S-2-(3-tert-butylamino-2-hydroxypropoxy)-3-cyanopyridine in human plasma.
S-2-(3-tert-Butylamino-2-hydroxypropoxy)-3-cyanopyridine was recovered (approximately 90%) from human plasma and detected by conversion to a diheptafluorobutyryl derivative for electron-capture GLC. A homolog served as an internal standard. The method measures plasma drug concentrations at the 5-ng/ml level and is suitable for plasma analysis from humans who receive a therapeutic oral dose.
D000959:Antihypertensive Agents / Q000097:blood*; D002849:Chromatography, Gas; D006801:Humans; D007700:Kinetics; D008722:Methods; D011725:Pyridines / Q000097:blood*; D013997:Time Factors
D000959:Antihypertensive Agents; D011725:Pyridines; C021276:MK 761