title: Molecular recognition of nucleotides by means of ionic interaction in hydrophobic media.
abstract: Adenosine phosphates, AMP, ADP and ATP were found to be recognized and extracted from aqueous to an organic phase by the newly prepared lipophilic diammonium salt, N,N'-distearyldiammonium dichloride of 1,4-diazabicyclo [2.2.2] octane 1. ADP and ATP were specifically bound by 1 under the condition of no appreciable binding of AMP. The conventional phase transfer reagent, trioctylmethylammonium chloride 2 was far less effective and lacked selectivity fort the binding of adenosine phosphates. This diammonium salt was used as a specific carrier of ADP in the passive transport through a liquid membrane. A high selectivity was observed in the transport rate of ADP relative to that of AMP.
mesh_terms: D000244:Adenosine Diphosphate / Q000302:isolation & purification*; D000249:Adenosine Monophosphate / Q000302:isolation & purification*; D000255:Adenosine Triphosphate / Q000302:isolation & purification*; D001643:Bridged Bicyclo Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D002625:Chemistry, Organic; D055601:Organic Chemistry Phenomena; D010879:Piperazines
chemical_list: D001643:Bridged Bicyclo Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D010879:Piperazines; D000249:Adenosine Monophosphate; D000244:Adenosine Diphosphate; C025330:1,4-diazabicyclo(2.2.2)octane N,N'-distearyldiammonium; D000255:Adenosine Triphosphate