Studies on the renin-angiotensin-aldosterone system in elderly hypertensive patients with an angiotensin II antagonist.
1. To characterize the renin-angiotensin-aldosterone system in elderly hypertensive patients, an angiotensin II antagonist, [Sar1,Ile8]angiotensin II, was infused into individuals 60 years old and older with and without hypertension. 2. After infusion of [Sar1,Ile8]angiotensin II in all of the elderly patients and subjects an agonistic pressor response was observed that was greater than in middle-aged hypertensive patients. 3. Pre-infusion plasma renin activity and plasma aldosterone concentration in hypertensive and normotensive elderly groups were suppressed in comparison with those in middle-aged hypertensive subjects. The increased agonistic effects of [Sar1,Ile8]angiotensin II infusion on blood pressure in the elderly are presumably due to their hyporeninaemia. 4. The angiotensin-aldosterone system in elderly essential hypertensive patients is suppressed and is presumably not responsible for their elevated blood pressures.
D015059:1-Sarcosine-8-Isoleucine Angiotensin II; D000328:Adult; D000368:Aged; D000450:Aldosterone / Q000097:blood / Q000502:physiology*; D000804:Angiotensin II / Q000502:physiology*; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012083:Renin / Q000097:blood / Q000502:physiology*
D000804:Angiotensin II; D000450:Aldosterone; D015059:1-Sarcosine-8-Isoleucine Angiotensin II; D012083:Renin