N-acylglycines: gas chromatographic mass spectrometric identification and determination in urine by selected ion monitoring.
Eleven biologically interesting N-acylglycines have been synthesized and the gas chromatographic and mass spectrometric properties of their trimethylsilyl derivatives studied, A sharp and reproducible gas chromatographic peak could be obtained for each N-acylglycine as the N, O-bis-(trimethylsilyl)-N-acylglycine. By the use of these derivatives a sensitive and specific selected ion monitoring method for the determination of N-acylglycines in human urine has been developed.
D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D005998:Glycine / Q000031:analogs & derivatives* / Q000652:urine; D006801:Humans; D014297:Trimethylsilyl Compounds
D014297:Trimethylsilyl Compounds; D005998:Glycine