Antibiotics from basidiomycetes. IX. Oudemansin, an antifungal antibiotic from Oudemansiella mucida (Schrader ex Fr.) Hoehnel (Agaricales).
From mycelial cultures of Oudemansiella mucida a crystalline optically active antibiotic, oudemansin (2), has been isolated; its structure is closely related to strobilurin A (1). The relative configuration of oudemansin have been determined by X-ray analysis. The antibiotic exhibits strong antifungal properties and inhibits respiration in fungi, cells of the ascitic form of EHRLICH carcinoma, and rat liver mitochondria.
D000363:Agaricales / Q000378:metabolism*; D000818:Animals; D000935:Antifungal Agents / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005285:Fermentation; D066298:In Vitro Techniques; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D014631:Valerates / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology
D000935:Antifungal Agents; D014631:Valerates