Removal of uraemic toxins by haemofiltration with different membranes. The benefit of regenerating haemofiltrate using a newly developed system.
Based on earlier results which indicate that certain uraemic toxins (verified by an in vitro assay system) are larger than 10,000 daltons - a new system for treatment of endstage renal failure, SElective DUal Filtration ARtificial Kidney (SEDUFARK) has been developed. This system consists of a multimembrane filter/dialyser unit making removal of small molecules (mol wt less than 200) and substances in the mol wt range 10,000 - 40,000 possible without exchange of body fluids. Evaluation of pre and post treatment uraemic plasma with the bio assay showed that SEDUFARK was superior to conventional haemofiltration (CHF) with polyacrylonitrile (PAN) or Gambro Lundia Major High Flux 1.36 m2 (CPN) membranes as filters.
D001769:Blood; D006801:Humans; D007688:Kidneys, Artificial; D008566:Membranes; D010586:Phagocytes; D006435:Renal Dialysis; D014118:Toxins, Biological; D014462:Ultrafiltration / Q000295:instrumentation*; D014511:Uremia / Q000628:therapy*
D014118:Toxins, Biological