2,2'-Dithiodipyridine activates aldehyde dehydrogenase and protects the enzyme against inactivation by disulfiram.
Small concentrations of 2,2'-dithiodipyridine cause a rapid activation of sheep liver cytoplasmic aldehyde dehydrogenase in the presence of NAD+. Enzyme pre-modified by 2,2'-dithiodipyridine is largely protected against the potent inactivatory effect of disulfiram. 2,2'-Dithiobis-(5-nitropyridine) inactivates the enzyme. The implications of these results are discussed with reference to various possible classes of thiol group in aldehyde dehydrogenase.
D015082:2,2'-Dipyridyl / Q000031:analogs & derivatives / Q000494:pharmacology*; D000445:Aldehyde Oxidoreductases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D004220:Disulfides / Q000494:pharmacology*; D004221:Disulfiram / Q000494:pharmacology*; D004789:Enzyme Activation / Q000187:drug effects; D011725:Pyridines / Q000494:pharmacology*
D004220:Disulfides; D011725:Pyridines; C001105:2,2'-dipyridyl disulfide; D015082:2,2'-Dipyridyl; D000445:Aldehyde Oxidoreductases; D004221:Disulfiram