[Effect of mitochondria and microsomal fractions on glycolytic activity of rat brain and liver tissues under hypoxia].
It is found that acute hypoxia inhibits the glycolytic activity of postmitochondrial fraction in the liver, activates in the brain, but has no effect on glycolysis under conditions of a preliminary administration of diethylaminoethylamide of parachlorophenoxyacetic acid--antihypoxic preparation. In the processes of two- and four-week interrupted training of adaptation to hypoxia the activity of the liver glycolytic system rises. Suspensions of the mitochondric and microsomal fraction added in definite ratios to the postmitochondrial fraction of the brain and liver intensify its glycolytic activity both in control and hypoxic animals. The activating effect of mitochondria is higher as compared with the control when glycolysis is decreased; when glycolysis is increased the phenomenon is not observed. A mechanism of the found changes in glycolysis and the validity of the tissue glycolysis estimation from the activity of the postmitochondrial fraction are discussed.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D003600:Cytosol / Q000378:metabolism; D006019:Glycolysis; D000860:Hypoxia / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D008861:Microsomes / Q000502:physiology*; D008862:Microsomes, Liver / Q000502:physiology; D008928:Mitochondria / Q000502:physiology*; D008930:Mitochondria, Liver / Q000502:physiology; D009928:Organ Specificity; D051381:Rats
Vliianie mitokhondriĭ i mikrosomnoĭ fraktsii na glikoliticheskuiu aktivnost' tkaneĭ mozga i pecheni krys pri gipoksii.