A gas chromatographic screening procedure for the detection of non-steroidal anti-inflammatory drugs in horse urine.
A gas chromatographic screening procedure for the non-steroidal anti-inflammatory group of drugs is described. The method invovles on-column methylation of the carboxylic acid group using trimethylanilinium hydroxide as the methylating reagent. Fifteen such drugs were studied. Eight of these were detected in urine collected from horses that had received these compounds orally and for these drugs, rates of urinary excretion are recorded. Seven other members of this group of drugs were shown to be detectable by this procedure but in these cases the drug was added to urine and not administered to the horse.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000652:urine*; D002849:Chromatography, Gas; D006736:Horses / Q000652:urine*; D007213:Indomethacin / Q000652:urine; D008297:Male; D008469:Meclofenamic Acid / Q000652:urine
D000893:Anti-Inflammatory Agents; D008469:Meclofenamic Acid; D007213:Indomethacin