Liquid chromatographic determination of methscopolamine bromide in various veterinary formulations.
A reverse phase paired ion liquid chromatographic procedure is described for determining methscopolamine bromide (Pamine) in the presence of neomycin sulfate in 5 veterinary formulations (Biosol M). Methscopolamine bromide is separated from neomycin sulfate and other formulation excipients by extraction into ethanol. The sample preparations are then concentrated and dissolved in water before chromatography. Recovery of methscopolamine bromide added to 5 placebo formulations ranged from 99.7 to 100.7%, with relative standard deviations of less than 2%. Specificity of the method with regard to potential degradation products is demonstrated.
D000930:Antidiarrheals / Q000032:analysis*; D002853:Chromatography, Liquid; D004304:Dosage Forms / Q000032:analysis; D004338:Drug Combinations; D009355:Neomycin; D011208:Powders / Q000032:analysis; D012602:Scopolamine Derivatives / Q000032:analysis*; D013607:Tablets / Q000032:analysis; D014730:Veterinary Medicine
D000930:Antidiarrheals; D004304:Dosage Forms; D004338:Drug Combinations; D011208:Powders; D012602:Scopolamine Derivatives; D013607:Tablets; D009355:Neomycin