[Cimetidine for treatment of stress-induced ulcer haemorrhage (author's transl)].
After gastroscopic demonstration of a definite source of bleeding (gastric or duodenal erosions or ulcers) 56 stress patients were treated with 1,200 mg cimetidine intravenously per day (constant infusion or 200 mg intravenously 4-hourly) in an open prospective study. Not considering 2 false indications because of arterial arrosion 46 patients were treated successfully with cimetidine. Bleeding could not be arrested in 7 cases and 2 of these succumbed, one of them despite repeated operations. In one patient bleeding was arrested; however, operation was necessary in the end due to perforation. Cimetidine has proved to be of value in conservative treatment of stress induced ulcer haemorrhage and is used increasingly prophylactically.
D000328:Adult; D000368:Aged; D002927:Cimetidine / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006146:Guanidines / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010438:Peptic Ulcer Hemorrhage / Q000188:drug therapy* / Q000209:etiology; D011446:Prospective Studies; D013312:Stress, Physiological / Q000150:complications*
D006146:Guanidines; D002927:Cimetidine
Therapie von Stressulkusblutungen mit Cimetidin.