Interaction between theophylline and oestrogen in the rat uterus.
Theophylline alone or in the presence of 0.001, 0.01, 0.1 or 1 microgram oestradiol-17 beta/100 g body wt increase uterine RNA and protein content 6 h after administration. Uterine oedema induced by physiological doses of oestradiol-17 beta was increased further in the presence of theophylline. Theophylline decreased the number of eosinophils in the blood and concurrently decreased oestrogen-induced uterine oesinophilia at doses of 0.01, 0.1, 1, 10 or 30 micrograms oestradiol-17 beta/100 g body wt. Oestrogen binding by uterine eosinophils in vitro increased in the presence of theophylline. This effect of theophylline could explain the increase of oestrogen-induced uterine oedema in vivo.
D000818:Animals; D004347:Drug Interactions; D004804:Eosinophils / Q000187:drug effects / Q000378:metabolism; D004958:Estradiol / Q000378:metabolism / Q000494:pharmacology*; D005260:Female; D007958:Leukocyte Count; D011506:Proteins / Q000378:metabolism; D012313:RNA / Q000378:metabolism; D051381:Rats; D013268:Stimulation, Chemical; D013806:Theophylline / Q000494:pharmacology*; D014599:Uterus / Q000187:drug effects / Q000378:metabolism*
D011506:Proteins; D004958:Estradiol; D012313:RNA; D013806:Theophylline