Effect of cadmium and copper on monoamine oxidase type A and B in brain and liver mitochondria.
The effect of cadmium and copper on monoamine oxidase type A and B in mitochondrial preparations from brain and liver was determined in vitro. The results showed a dose-related inhibition of the enzyme. Both the A and B forms of the enzyme were similarly inhibited by the presence of either cadmium or copper. Copper has been shown to be a 7-8 times more potent inhibitor of monoamine oxidase than cadmium. The data suggest that the intracellular concentration of unbound copper (13 mumol/l) or cadmium (100 mumol/l) may inhibit monoamine oxidase in brain and liver by 50%.
D000818:Animals; D001921:Brain / Q000201:enzymology*; D002104:Cadmium / Q000494:pharmacology*; D003300:Copper / Q000494:pharmacology*; D007527:Isoenzymes / Q000378:metabolism; D007700:Kinetics; D008297:Male; D008928:Mitochondria / Q000201:enzymology*; D008930:Mitochondria, Liver / Q000201:enzymology*; D008995:Monoamine Oxidase / Q000378:metabolism*; D051381:Rats; D013056:Spectrophotometry, Ultraviolet
D007527:Isoenzymes; D002104:Cadmium; D003300:Copper; D008995:Monoamine Oxidase