Similarity of the intraocular pressure response to different corticosteroid esters when compliance is controlled.
Fifty-four subjects with initial intraocular pressures under 20 mm Hg received a different commercial corticosteroid ester of prednisolone or dexamethasone in each eye for three to six weeks. Compliance was controlled. The intraocular pressure responses of the two eyes of a subject were similar. It was concluded that the absorptions of all four corticosteroids were in excess of the minimum amounts needed to maximally elevate pressure. Subjects complained that prednisolone acetate was irritating. Corticosteroid-induced uveitis developed in 3% (3) of the eyes.
D000085:Acetates; D000287:Administration, Topical; D000305:Adrenal Cortex Hormones / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000009:adverse effects / Q000494:pharmacology; D003907:Dexamethasone / Q000494:pharmacology; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D010710:Phosphates; D011239:Prednisolone
D000085:Acetates; D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents; D010710:Phosphates; D003907:Dexamethasone; D011239:Prednisolone