Nonrandom distribution of chromosomal aberrations induced by three chemicals.
The G-band locations of 3244 breakpoints induced by cis-platinum (II) diamminedichloride (PDD), 1460 breakpoints induced by cytosine arabinoside (ara-C), and 1257 breakpoints induced by triethylenemelamine (TEM) in human lymphocyte chromosomes were identified. The breakpoints induced by each of these chemicals demonstrated a significantly nonrandom distribution within the human karyotype. The overall pattern of the interarm distribution was dependent upon the chemical used, but certain chromosomes arms exhibited similar responses to all 3 chemicals. Comparison of the frequencies of breakpoints within individual G-bands indicated that (1) certain bands were susceptible to damage induced by all 3 chemicals; (2) certain bands were resistant to damage by all 3 chemicals; (3) certain bands demonstrated variable susceptibility to induced damage dependent upon the chemical agent; and (4) other bands demonstrated near expected frequencies of damage (by length) to all 3 agents.
D002478:Cells, Cultured; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002875:Chromosomes / Q000187:drug effects*; D002945:Cisplatin / Q000494:pharmacology*; D003561:Cytarabine / Q000494:pharmacology*; D014644:Genetic Variation; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure; D014265:Triethylenemelamine / Q000494:pharmacology*
D003561:Cytarabine; D014265:Triethylenemelamine; D002945:Cisplatin