Structural biochemistry. 17. Synthesis of tryptophan dipeptides.
Boc-Trp-Leu hydrazide has been found to significantly inhibit growth of the L-1210 and P388 murine lymphocytic leukemias. A series of related tryptophan dipeptides were prepared and found to be devoid of such activity. The tryptophan dipeptides were most conveniently obtained employing the DCCI-NHS peptide bond-forming procedure.
D000595:Amino Acid Sequence; D000818:Animals; D004151:Dipeptides / Q000138:chemical synthesis* / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D006852:Hydrochlorothiazide / Q000627:therapeutic use; D007939:Leukemia L1210 / Q000188:drug therapy; D007941:Leukemia P388 / Q000188:drug therapy; D051381:Rats; D014364:Tryptophan / Q000138:chemical synthesis* / Q000627:therapeutic use
D004151:Dipeptides; D006852:Hydrochlorothiazide; D014364:Tryptophan