Wilson's disease; increased aluminum in liver.
Interaction of trace metal metabolism was studied in a patient with Wilson's dease. Atomic absorption analysis showed markedly increased urinary excretion of copper and aluminum and an increased aluminum content was found in the biopsied liver by neutron activation analysis. These findings suggest a complicated pathogenetic mechanism involving other metals besides copper in the Wilson's disease.
D000535:Aluminum / Q000378:metabolism*; D000690:Amyotrophic Lateral Sclerosis / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D002648:Child; D003300:Copper / Q000378:metabolism; D006527:Hepatolenticular Degeneration / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008103:Liver Cirrhosis / Q000378:metabolism; D008297:Male; D008345:Manganese / Q000378:metabolism
D008345:Manganese; D003300:Copper; D000535:Aluminum; D002118:Calcium