[Interactions between macromolecular adjuvants and drugs. Part 18: The binding behaviour of sodium carboxymethylcellulose and other macromolecules towards streptomycin sulphate (author's transl)].
Unlike the other macromolecules under investigation (polyvinylpyrrolidone, methylcellulose, polyvinyl alcohol), sodium carboxymethylcellulose acts on streptomycin sulphate, which leads to isolable precipitates. By equilibrium dialysis in electrolyte-free and electrolyte-containing solutions, the interaction was characterized in more detail and described by Donnan curves. The associates (which contained, on an average, 40% of streptomycin) proved to be resistant to light and air, and stable to thin-layer chromatography. Microbiological assays on the test strain Bacillus subtilis SG119 revealed a decrease in activity of the streptomycin-sodium carboxymethylcellulose associates compared to pure streptomycin (tested in the solid form, using rice granulate as a carrier substance). In contrast, the associate was as efficient as the antibiotic when dissolved in a concentrated solution of sodium chloride.
D000277:Adjuvants, Pharmaceutic; D002266:Carboxymethylcellulose Sodium; D002626:Chemistry, Pharmaceutical; D046911:Macromolecular Substances; D008747:Methylcellulose / Q000031:analogs & derivatives; D013307:Streptomycin
D000277:Adjuvants, Pharmaceutic; D046911:Macromolecular Substances; D008747:Methylcellulose; D002266:Carboxymethylcellulose Sodium; D013307:Streptomycin
Wechselwirkungen zwischen makromolekularen Hilfsstoffen und Arzneistoffen. 18. Mitteilung: Bindungsverhalten von Natriumcarboxymethylcellulose und anderen Makromolekülen gegenüber Streptomycinsulfat.