Comparison of a water-soluble and a water-insoluble podophyllotoxin derivative in murine neoplasms.
Comparison of a water-soluble (27-487) with a water-insoluble (VP-16-213) podophyllotoxin derivative in seven murine neoplasms revealed slight therapeutic superiortiy of VP-16-213 but also slightly greater toxicity when compared with 27-487. A strikingly good response of the Taper liver tumor to both compounds was observed, providing further incentive to the use of podophyllotoxin derivatives in human hepatomas.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005047:Etoposide / Q000627:therapeutic use* / Q000633:toxicity; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D011034:Podophyllotoxin / Q000031:analogs & derivatives* / Q000627:therapeutic use / Q000633:toxicity; D012995:Solubility; D014867:Water
D014867:Water; D005047:Etoposide; D011034:Podophyllotoxin