Comparison of the antitussive effects of codeine phosphate 20 mg, dextromethorphan 30 mg and noscapine 30 mg using citric acid-induced cough in normal subjects.
1. Protection by codeine 20 mg, dextromethorphan 30 mg, noscapine 30 mg, and placebo against citric acid-induced cough was determined in eighteen healthy subjects. 2. Drug differences occurred at 2 1/2 h following ingestion of the drugs but not at 1 1/4 h. 3. Only coideine 20 mg had a greater antitussive action than placebo, but dextromethorphan 30 mg also did not differ from codeine 20 mg. 4. This technique may offer a useful screening test for the activity of new potential antitussive compounds in man.
D000996:Antitussive Agents; D002951:Citrates / Q000494:pharmacology; D003061:Codeine / Q000494:pharmacology*; D003371:Cough / Q000139:chemically induced / Q000503:physiopathology; D003915:Dextromethorphan / Q000494:pharmacology*; D006801:Humans; D007981:Levorphanol / Q000031:analogs & derivatives*; D009665:Noscapine / Q000494:pharmacology*; D013997:Time Factors
D000996:Antitussive Agents; D002951:Citrates; D007981:Levorphanol; D003915:Dextromethorphan; D009665:Noscapine; D003061:Codeine