The influence of 5-nitro-2-furyl acrylic acid on human fibroblasts cultivated in vitro.
The authors studied the in vitro effects of 5-nitro-2-furyl acrylic acid on growth activity of EUE human fibroblasts. They investigated the course and intensity of macromolecular syntheses, mainly DNA synthesis in these cells. Going by the results obtained it can be concluded that the cytotoxic effects of 5-nitro-2-furyl acrylic acid are also connected with its genotoxic effects, since that substance will induce damage to DNA in human cells.
D000179:Acrylates / Q000494:pharmacology*; D002460:Cell Line; D003470:Culture Media; D004247:DNA / Q000096:biosynthesis; D005347:Fibroblasts / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D009581:Nitrofurans / Q000494:pharmacology*; D012313:RNA / Q000096:biosynthesis; D013936:Thymidine / Q000378:metabolism
D000179:Acrylates; D003470:Culture Media; D009581:Nitrofurans; D012313:RNA; D004247:DNA; D013936:Thymidine