Rates of release of subcutaneously injected antigens in the rat. Comparison of an aqueous preparation with two alum-precipated preparations.
Release of antigen E-125 I from the site of subcutaneous injection in male rats was delayed significantly when either of two alum-precipitated preparations containing 1.0-1.2 mg of Al/ml was administered rather than an aqueous preparation. The rates of 125I excretion were similarly influenced being statistically slower through the first week after single doses of the alum-precipitated preparations. The results of these studies strongly support the view that alum-precipitated vaccines offer more protection from system reactions than aqueous vaccines.
D000042:Absorption; D000485:Allergens / Q000008:administration & dosage* / Q000494:pharmacology; D000534:Alum Compounds / Q000008:administration & dosage*; D000535:Aluminum / Q000008:administration & dosage*; D000818:Animals; D000941:Antigens / Q000008:administration & dosage; D007279:Injections, Subcutaneous; D007457:Iodine Radioisotopes; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage*; D051381:Rats; D011919:Rats, Inbred Strains; D012107:Research Design
D000485:Allergens; D000534:Alum Compounds; D000941:Antigens; D007457:Iodine Radioisotopes; D010936:Plant Extracts; D000535:Aluminum