title: [The molecular biology of aging -- 14: Structure and function of the genetic apparatus in aging. I. Changes in the genome].
abstract: In the last years there is agreement over the fact that genetic properties have an essential influence on the ageing process. Therefore many scientists choose the genom and its properties as object of the gerontological investigation. This review shows that changes are possible on all of structure levels of the genom down to the lowest molecular stage with increasing age. This concerns as well postmitotic as intermitotic, proliferating cells and tissues, too. Actually repair processes of defective DNA find an increasing consideration. Until now it is not possible to establish if the observed changes are the cause or the result of ageing processes.
mesh_terms: D000375:Aging; D002843:Chromatin / Q000235:genetics; D002869:Chromosome Aberrations; D004247:DNA / Q000096:biosynthesis / Q000235:genetics; D004260:DNA Repair; D004261:DNA Replication; D005057:Eukaryotic Cells / Q000166:cytology; D005796:Genes; D006801:Humans; D008938:Mitosis; D011003:Ploidies
chemical_list: D002843:Chromatin; D004247:DNA
vernacular_title: Zur Molekularbiologie des Alterns -- 14. Mitteilung: Struktur und Funktion des genetischen Apparates im Alternsgang. I. Veränderungen am Genom.