[Effect of lithium oxybutyrate on excitability of the cortex and some subcortical structures in rabbit brain].
Lithium oxybutyrate microinjections (10 mg/ml) produce a depressant action on spontaneous bioelectrical activity of the cortex and subcortical structure. The drug brings down excitability of the motor cortex, hippocampus, caudate nucleus, thalamus, posterior hypothalamus and mesencephalic reticular formation; it also raises excitability of the tonsils. The depressant effect of lithium oxybutyrate is superior to that of lithium chloride.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology*; D006885:Hydroxybutyrates / Q000494:pharmacology*; D008094:Lithium / Q000494:pharmacology*; D009928:Organ Specificity; D009942:Organometallic Compounds; D011817:Rabbits; D013329:Structure-Activity Relationship
D006885:Hydroxybutyrates; D009942:Organometallic Compounds; C022826:lithium hydroxybutyrate; D008094:Lithium
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