[Kinetics of the reactions to experimental infection in mice after or without vaccination against rabies: study of etio-pathogenesis (author's transl)].
When challenged by intramuscular route with the rabies strain CVS, mice treated with cyclophosphamide and then vaccinated died during the four days following vaccination in larger numbers and earlier than controls which had been treated but not vaccinated. This phenomenon can be transferred, via splenocytes of mice treated with cyclophosphamide and then vaccinated, into syngenic mice infected 24 h earlier by a large amount of virus (10.000 LD50 by intracerebral route). On the other hand, mice infected with a small amount of virus (1 LD50 by intracerebral route) can be protected by transferred splenocytes. These data suggest that an immunopathological phenomenon is involved in experimental rabies of mice, supported by direct or indirect action of T lymphocytes against infected target cells. Possible implications of this hypothesis in pre- or post-exposure vaccination are discussed.
D000818:Animals; D003520:Cyclophosphamide / Q000494:pharmacology; D007116:Immunization, Passive; D007700:Kinetics; D007928:Lethal Dose 50; D051379:Mice; D011818:Rabies / Q000517:prevention & control*; D011819:Rabies Vaccines / Q000276:immunology*; D013154:Spleen / Q000166:cytology; D013997:Time Factors
D011819:Rabies Vaccines; D003520:Cyclophosphamide
Cinétique des réactions à l'infection expérimentale de la souris vaccinée ou non contre la rage: étude étio-pathogénique.