Regeneration of proximal tubules of the rat kidney following sublimate necrosis. A scanning electron microscopic study.
Necrosis of the proximal tubules of the rat kidney was induced by low (1.5 mg/kg) doses of sublimate. Epithelial necrosis and regeneration were followed by scanning electron microscopy for 10 days. Regressive and regenerative processes were observed simultaneously. The naked basement membrane is first invaded by flat epithelial cells lacking microvilli. Within a few hours microvilli appear followed by the formation of regular brush-border and interdigitations cells. After 7--10 days the newly formed epithelium cannot be distinguished from the intact one.
D000818:Animals; D007684:Kidney Tubules / Q000648:ultrastructure; D007687:Kidney Tubules, Proximal / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008628:Mercury / Q000494:pharmacology; D008630:Mercury Poisoning / Q000473:pathology*; D008855:Microscopy, Electron, Scanning; D051381:Rats; D012038:Regeneration
D008628:Mercury