Two-stage plans for patient accrual in phase II cancer clinical trials.
This paper considers two-stage patient-accrual plans for phase II trials of anticancer drugs. The purpose is to identify the therapeutic level of drugs as either above or below a reference response rate. Using such a plan, decisions concerning the future disposition of drugs can be made more formally and objectively. The tables used to implement the plan are prepared for a 20% reference response rate, due to its wide acceptance in the design of phase II clinical trials.
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003657:Decision Making; D004341:Drug Evaluation; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D012075:Remission, Spontaneous; D013223:Statistics as Topic
D000970:Antineoplastic Agents