Evidence for intracochlear impedance changes following ethacrynic acid administration.
The effects of intra-arterial 30-, 40-, and 50-mg/kg doses of ethacrynic acid upon cochlear function in guinea pigs were studied for periods of three to five hours. Cochlear potentials recorded in the first turn included the endocochlear potential, whole nerve response, cochlear microphonics, and summating potentials in scala media, scala tympani, and scala vestibuli. Evidence of organ of Corti damage at 50 mg/kg was found in addition to electrical impedance changes in the cochlear membranes at all dose levels.
D000818:Animals; D003053:Cochlear Duct / Q000502:physiology; D003055:Cochlear Microphonic Potentials / Q000187:drug effects; D004976:Ethacrynic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D006168:Guinea Pigs; D009925:Organ of Corti / Q000502:physiology; D012533:Scala Tympani / Q000502:physiology; D013316:Stria Vascularis / Q000502:physiology; D000159:Vestibulocochlear Nerve / Q000502:physiology
D004976:Ethacrynic Acid