Mitochondrial glutamic oxaloacetic transaminase and its clinical significance.
The m-GOT were studied in 57 patients with liver diseases, diagnosed by peritoneoscopy and biopsy. In acute hepatitis, the m-GOT rose to 100 units or there-about. But in chronic hepatitis, even in hepatitis B with sublobular necrosis, the m-GOT were low and 20--30 units. On the other hand, in alcoholic hepatitis, the m-GOT were 50--60 units which may be considered to be higher than expected for comparable their histological necrotic findings. These values were higher than OCT, which were measured at the same time. This results showed that there might be m-GOT induction by alcohol. In liver cirrhosis lower values were obtained. Generally m-GOT was liable to be lower as the lobular distortion was getting severer.
D000328:Adult; D001219:Aspartate Aminotransferases / Q000378:metabolism*; D005260:Female; D006505:Hepatitis / Q000201:enzymology; D006519:Hepatitis, Alcoholic / Q000201:enzymology; D006801:Humans; D008107:Liver Diseases / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D008930:Mitochondria, Liver / Q000201:enzymology*
D001219:Aspartate Aminotransferases