Induction of hypothermia in mice by semi-artificial cells containing indolyl-3-alkane alpha-hydroxylase.
The administration of red cell ghost encapsulated indolyl-3-alkane alpha-hydroxylase (an enzyme which destroys tryptophan by oxidation of the side chains) in CD-1 female mice causes effective tryptophan depletion in plasma and brain and induces hypothermia by probably decreasing the serotonin concentration in brain by decreasing the concentration of its precursor, L-tryptophan.
D000473:Alkanes; D000818:Animals; D004910:Erythrocyte Membrane / Q000201:enzymology*; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D007035:Hypothermia / Q000209:etiology*; D007211:Indoles; D008099:Liver / Q000201:enzymology; D051379:Mice; D006899:Mixed Function Oxygenases / Q000097:blood / Q000494:pharmacology*; D013154:Spleen / Q000201:enzymology; D014364:Tryptophan / Q000032:analysis / Q000097:blood*
D000473:Alkanes; D007211:Indoles; D014364:Tryptophan; D006899:Mixed Function Oxygenases