title: Intercellular junctions in the full term human placenta. I. Syncytiotrophoblastic layer.
abstract: Inter- and intrasyncytiotrophoblastic junctions within the human full term placenta were electronmicroscopically investigated using thin sections and freeze-fracturing. Narrow clefts were occasionally situated between surface areas where adjacent chorionic villi exhibited close contact. Within these clefts, extensive zonulae and maculae occludentes and numerous maculae adherentes were found. The zonulae occludentes showed a continuous and irregular course on the membrane surface, and the maculae occludentes were irregularly distributed over extended membrane areas. Besides these areas, maculae occludentes and maculae adherentes were observed on infoldings and invaginations of the synctiotrophoblastic surface membrane. Investigations of the inner surface of the syncytiotrophoblastic layer, that is, the layer facing the villous stroma, also revealed invaginations joined by maculae adherentes. The functional significance of the inter- and intrasyncytiotrophoblastic junctions is discussed with respect to the differentiation of the trophoblast.
mesh_terms: D005260:Female; D005614:Freeze Fracturing; D006801:Humans; D007365:Intercellular Junctions / Q000648:ultrastructure*; D008854:Microscopy, Electron; D010920:Placenta / Q000648:ultrastructure*; D011247:Pregnancy; D014327:Trophoblasts / Q000648:ultrastructure