Thyroid hormones and protein synthesis in fetal mouse liver erythroid cells.
Hemoglobin synthesis represents an important step in the maturation of the developing erythron. In this study, we determined the effect of various thyroid hormones and analogs upon globin synthesis by fetal mouse liver erythroid cells. Globin synthesis was stimulated in 13--15 day fetal liver erythroid cells, whereas cells, whereas cells from 17 day fetuses were unresponsive. There was no correlation between stimulation of globin synthesis and reported calorigenic activity of the various hormones assayed.
D000818:Animals; D004920:Erythropoiesis / Q000187:drug effects*; D006454:Hemoglobins / Q000096:biosynthesis*; D008099:Liver / Q000196:embryology* / Q000378:metabolism; D051379:Mice; D008809:Mice, Inbred C3H; D013963:Thyroid Hormones / Q000494:pharmacology*; D013974:Thyroxine / Q000494:pharmacology; D014284:Triiodothyronine / Q000031:analogs & derivatives / Q000494:pharmacology
D006454:Hemoglobins; D013963:Thyroid Hormones; D014284:Triiodothyronine; D013974:Thyroxine