A wearable artificial glomerulus.
We have shown that hemofiltration can be conducted for 16 hrs/day for more than 3 continuous days by connecting an Amicon 0.2 M2 hemofilter to an arteriovenous shunt. We can produce over 8 ml/min of ultrafiltrate with no external pump, and this ultrafiltrate can be replaced by having the patient drink an electrolyte-glucose solution. Anticoagulation can be attained with heparin, warfarin and cyproheptadine. Each filter can be expected to function at least 48 hrs before it must be replaced.
D005374:Filtration / Q000295:instrumentation; D005440:Fluid Therapy; D006493:Heparin / Q000627:therapeutic use; D007408:Intestinal Absorption; D007678:Kidney Glomerulus; D007688:Kidneys, Artificial; D008567:Membranes, Artificial; D011312:Pressure; D011474:Prosthesis Design; D014462:Ultrafiltration / Q000295:instrumentation
D008567:Membranes, Artificial; D006493:Heparin