N-Formylation of an aromatic amine as a metabolic pathway.
1. Feeding 2-aminoanthraquinone (2-AAQ) in the diet to Fischer rats led to nephrotoxicity in females, caused by deposits of crystalline material in the kidney tubules. 2. This material consisted of 2-AAQ, N-acetyl-2-AAQ and N-formyl-2-AAQ. N-Formyl-2-AAQ was also identified in the ether extract of urine of rats fed 2-AAQ. 3. This represents the first case of identification of the N-formyl derivative of a primary aromatic amine as a metabolite in vivo.
D000588:Amines / Q000378:metabolism* / Q000633:toxicity; D000818:Animals; D000880:Anthraquinones / Q000378:metabolism* / Q000633:toxicity; D001835:Body Weight / Q000187:drug effects; D005260:Female; D005561:Formates / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism / Q000473:pathology; D008297:Male; D051381:Rats
D000588:Amines; D000880:Anthraquinones; D005561:Formates; C022970:2-aminoanthraquinone