Mechanism of action of the anthracycline anti-tumor antibiotics, doxorubicin, daunomycin and rubidazone: preferential inhibition of DNA polymerase alpha.
D000818:Animals; D002467:Cell Nucleus / Q000201:enzymology; D004259:DNA-Directed DNA Polymerase / Q000302:isolation & purification; D003630:Daunorubicin / Q000031:analogs & derivatives / Q000494:pharmacology; D004317:Doxorubicin / Q000494:pharmacology; D006498:Hepatectomy; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D019384:Nucleic Acid Synthesis Inhibitors; D051381:Rats; D011916:Rats, Inbred F344; D013696:Temperature
D019384:Nucleic Acid Synthesis Inhibitors; D004317:Doxorubicin; D004259:DNA-Directed DNA Polymerase; D003630:Daunorubicin