Absorbed dose estimation of some 99mTc-hepatobiliary agents.
The absorbed dose estimates of several organs after administration in humans of six new hepatobiliary agents (five 99mTc-Pyridoxal amino acid complexes and the 99mTc-HIDA) are presented in comparison with 131I-Rose-Bengal. The results indicated that the radiation doses absorbed by the total body and gonads as well as by the critical organ (upper part of the large intestine) are significantly lower than those of Rose Bengal. Therefore, the new 99mTc-agents can be safely applied to humans.
D000328:Adult; D000596:Amino Acids / Q000008:administration & dosage; D001659:Biliary Tract / Q000000981:diagnostic imaging*; D006801:Humans; D007098:Imino Acids / Q000008:administration & dosage; D008012:Lidocaine / Q000008:administration & dosage / Q000031:analogs & derivatives; D008099:Liver / Q000000981:diagnostic imaging*; D011730:Pyridoxal / Q000008:administration & dosage; D011829:Radiation Dosage; D011877:Radionuclide Imaging; D012395:Rose Bengal / Q000008:administration & dosage; D013667:Technetium / Q000008:administration & dosage*; D014018:Tissue Distribution
D000596:Amino Acids; D007098:Imino Acids; D012395:Rose Bengal; D011730:Pyridoxal; D013667:Technetium; D008012:Lidocaine