[Effects of adenosine triphosphate on the postrotatory nystagmus and disorders of vestibular function (author's transl)].
Effects of adenosine triphosphate (ATP) on the postrotatory-induced nystagmus in rabbits and disorders of vestibular function induced by repeated administration of streptomycin in guinea pigs were studied. ATP-2Na exerted little influence on the postrotatory nystagmus in doses of 3 and 10 mg/kg, i.v., while slight suppressive effects were noted with a dose of 30 mg/kg. On the other hand, diphenidol hydrochloride remarkably suppressed the postrotatory nystagmus in a dose of 3 mg/kg i.v.. The disturbance in vestibular function following administration of streptomycin sulfate (400 mg/kg i.m., once daily x 9) was significantly alleviated when concomitant treatment with ATP-2Na (3 mg/kg i.p., 10 mg/kg i.p. and 100 mg/kg p.o., once daily x 14) or diphenidol hydrochloride (50 mg/kg p.o., once daily x 14) was given. ATP as well as diphenidol alleviated disorders in the vestibular function, while ATP had little influence on vestibular function in intact animals.
D000255:Adenosine Triphosphate / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D000284:Administration, Oral; D000818:Animals; D006168:Guinea Pigs; D007274:Injections, Intraperitoneal; D007759:Labyrinth Diseases / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D009759:Nystagmus, Pathologic / Q000188:drug therapy*; D011817:Rabbits; D013307:Streptomycin
D000255:Adenosine Triphosphate; D013307:Streptomycin