[Effect of the beta-adrenoblocker propranolol on adrenaline-stimulated lipolysis in the adipose tissue of spontaneously hypertensive rats].
The effect of the beta-adrenoblocker propranolol on adrenaline-stimulated lipolysis was studied in the adipose tissue of spontaneously hypertensive rats (SHR) and control rats. The lipolytic activity was estimated from the increase in glycerol concentration in the incubation medium in vitro. The adipose tissue of SHR responded to adrenaline similarly to that of control rats, but the concentration of adrenaline inducing the half-maximum response (KA) was 2 times less for SHR than KA for normotensive controls. Under propranolol effect this parameter was increased more significantly in SHR than in controls. These data indicate higher sensitivity of SHR adipose tissue to propranolol that may well be relative to alteration of the properties of beta-adrenergic receptors of adipose tissue in this form of hypertension.
D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D004837:Epinephrine / Q000494:pharmacology*; D006973:Hypertension / Q000235:genetics / Q000378:metabolism*; D007700:Kinetics; D008053:Lipid Mobilization / Q000187:drug effects*; D011433:Propranolol / Q000378:metabolism*; D051381:Rats
D011433:Propranolol; D004837:Epinephrine
Deĭstvie beta-adrenoblokatora propranolola na adrenalinovyĭ lipoliz v zhirovoĭ tkani krys so spontannoĭ geneticheskoĭ gipertonieĭ.