title: [Total atrophy of the villi during primary agammaglobulinemia in adults. Therapeutic problems (author's transl)].
abstract: A 21-year-old man presented with a 10-year history of a malabsorption syndrome of moderate severity, splenomegaly, and recurrent respiratory infections. Investigations revealed total atrophy of the villi and primary agammaglobulinemia. A gluten-free diet was ineffective. In spite of the absence of lambliasis, treatment with metronidazole produced objective clinical improvement and biological signs of healing of the malabsorption syndrome, but no alteration in the agammaglobulinemia. The authors discuss the relationship between total villous atrophy and primary agammaglobulinemias and the mode of action of metronidazole.
mesh_terms: D000276:Adjuvants, Immunologic; D000328:Adult; D000361:Agammaglobulinemia / Q000150:complications* / Q000175:diagnosis; D001284:Atrophy / Q000150:complications / Q000188:drug therapy; D003967:Diarrhea / Q000209:etiology; D005873:Giardiasis / Q000150:complications; D006801:Humans; D007421:Intestine, Small / Q000473:pathology*; D008297:Male; D008795:Metronidazole / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000276:Adjuvants, Immunologic; D008795:Metronidazole
vernacular_title: Atrophie villositaire totale au cours d'un déficit primaire global en immunoglobulines de l'adulte. Difficultés thérapeutiques.