Time courses and refractoriness of enhanced vascular permeability induced by histamine, serotonin and bradykinin in synovialis of the rat.
Enhanced vascular permeability induced in synovialis of the rat by histamine and serotonin lasts 5-15 min and that induced by bradykinin less than 5 min. Synovialis of the rat becomes refractory to the permeability effects of repeated doses of each of these substances in the hour following initial application.
D000818:Animals; D001920:Bradykinin / Q000494:pharmacology*; D002199:Capillary Permeability / Q000187:drug effects*; D005260:Female; D006632:Histamine / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D051381:Rats; D012701:Serotonin / Q000494:pharmacology*; D013582:Synovial Fluid / Q000187:drug effects / Q000502:physiology*
D012701:Serotonin; D006632:Histamine; D001920:Bradykinin