The effect of antifungal agents on pancreatic and gastric secretion in rats.
This study was designed to investigate the effects of griseofulvin, 5-fluorocytosine (5-FC), and amphotericin B on pancreatic and gastric secretion after the administration of a single large dose, or repeated small doses for 3 weeks, in male albino rats. The exocrine functions of the main digestive glands were only slightly affected by griseofulvin and were not affected by 5-FC. In contrast, a single large dose of amphotericin B caused a marked inhibition of exocrine functions of the main digestive glands. The rats treated with 5-FC lost body weight markedly during 2 weeks of administration.
D000666:Amphotericin B / Q000494:pharmacology; D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D001646:Bile / Q000187:drug effects / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D005260:Female; D005437:Flucytosine / Q000494:pharmacology; D005750:Gastric Juice / Q000187:drug effects* / Q000378:metabolism; D006118:Griseofulvin / Q000494:pharmacology; D010189:Pancreatic Juice / Q000187:drug effects* / Q000378:metabolism; D051381:Rats
D000935:Antifungal Agents; D006118:Griseofulvin; D000666:Amphotericin B; D005437:Flucytosine