title: [Relationship between Na+ and monosaccharide influx across the microvilli membrane depending on the energy state of the intestinal mucosa wall].
abstract: 1. An energy dependence of the Na+ influx and of the "extra-Na+ influx" across the microvilli membrane was demonstrated in an in vitro preparation of the rat jejunum by adjustment of low ATP/ADP quotients. The monosaccharide influx does not show this dependence. 2. The similar relationship of monosaccharide-dependent Na+ influx and Na+ influx without monosaccharide with the energy state in the mucosa cells suggests a common control system. 3. A constant stoichiometry between monosaccharide and "extra-Na+ influx" can be maintained only under constant intracellular conditions. 4. The changes of the Na+ and K+ influxes by so-called Na+ dependently transported monosaccharides correspond to those which can be elicited by lowering the ATP/ADP ratio in the in vitro preparation. 5. A mechanism is discussed in which an ATP-utilizing reaction is stimulated in the microvilli owing to the monosaccharide transport, thus locally discontinuing the condition for uncoupling of an (Na, K)-ATPase and eliciting an "extra-Na+ influx".
mesh_terms: D000244:Adenosine Diphosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism*; D005690:Galactose / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism*; D007583:Jejunum / Q000378:metabolism*; D007700:Kinetics; D008871:Microvilli / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism; D051381:Rats; D012964:Sodium / Q000378:metabolism*
chemical_list: D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D012964:Sodium; D011188:Potassium; D005690:Galactose
vernacular_title: Relation zwischen Na+- und Monosaccharid-Influx über die Mikrovillimembran in Abhängigkeit vom Energiezustand der intestinalen Mukosazelle.