title: Evidence for a positional memory in the development of the chick wing bud.
abstract: Grafts of quail zones of polarizing activity (ZPA), treated with 10000 rad gamma-radiation, tend to remain at the base of a limb. Their signalling ability is not passed on to more distal tissue, but the limb goes on to produce a reduplication. This suggests that the effect of a ZPA can be remembered in its absence, and explains why a normal limb can develop if its ZPA is removed.
mesh_terms: D000818:Animals; D002642:Chick Embryo; D009024:Morphogenesis; D011784:Quail / Q000196:embryology; D014183:Transplantation, Heterologous; D014921:Wings, Animal / Q000196:embryology* / Q000637:transplantation