The influence of prostaglandins and vasoactive amines on the intestinal phase of experimental trichinellosis in CBA mice and Wistar rats.
The intestinal phase of experimental trichinellosis in CBA mice and Wistar rats is modified by the intraduodenal injection of prostaglandin (PG) E1 and, to a greater extent by PG E2. The resulting changes are dose-dependent and are a function of the point of the infectious cycle at which the injection is performed. Three dose-related phenomena are thus observable: a delay, an acceleration of the process of expulsion of adult worms or no effect, the latter arising if the prostaglandins are injected later in the cycle. Under the same conditions, no significant effects are exerted by PG A, B or F, by histamine or by serotonin.
D000818:Animals; D002021:Buffers / Q000494:pharmacology; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006632:Histamine / Q000494:pharmacology*; D007422:Intestines / Q000469:parasitology; D051379:Mice; D010710:Phosphates / Q000494:pharmacology; D011453:Prostaglandins / Q000494:pharmacology*; D051381:Rats; D012701:Serotonin / Q000494:pharmacology*; D014235:Trichinellosis / Q000469:parasitology*
D002021:Buffers; D010710:Phosphates; D011453:Prostaglandins; D012701:Serotonin; D006632:Histamine; D004121:Dimethyl Sulfoxide