title: [Influence of a tributyltin oxide oily aerosol on the exploratory behaviour toward the mouse (author's transl)].
abstract: Inhalation of an oily aerosol of bis (tributyltin oxide) (TBTO) after single or repeated expositions (1 hour) disturb the exploratory behaviour in the mouse. Weak concentrations (42 and 84 ppm) stimulate exploratory activity while large doses (170 and 340 ppm) significantly decrease it. Modification in brain amine levels may appear but the observed perturbance seems to be more dependent from oily vehicule than TBTO itself.
mesh_terms: D000336:Aerosols; D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005106:Exploratory Behavior / Q000187:drug effects*; D008297:Male; D051379:Mice; D013997:Time Factors; D014220:Trialkyltin Compounds / Q000008:administration & dosage / Q000633:toxicity*
chemical_list: D000336:Aerosols; D001679:Biogenic Amines; D014220:Trialkyltin Compounds; C005961:bis(tri-n-butyltin)oxide
vernacular_title: Influence de l'oxyde de tributyletain (O.T.B.E.) en aérosol sur le comportement exploratoire chez la souris.