Antispasmodic activity of the tertiary base of Daucus carota, Linn. seeds.
A nitrogen containing base responding to Mayer's test and Dragendorff's reagent for tertiary bases has been isolated from the seeds of Daucus carota Linn. The effects of the base as its bromide have been studied on smooth muscles of ileum, uterus, blood vessels and trachea of different species of animals. The tertiary base has been found to have papaverine like nonspecific smooth muscle relaxant and spasmolytic activity, but its activity was found to be about one-tenth of that of papaverine.
D000818:Animals; D001001:Anura; D055598:Chemical Phenomena; D002621:Chemistry; D004285:Dogs; D005260:Female; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010276:Parasympatholytics; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D011817:Rabbits; D051381:Rats; D014132:Trachea / Q000187:drug effects; D014590:Uterine Contraction / Q000187:drug effects
D010276:Parasympatholytics; D010936:Plant Extracts