Effect of calcium ions on ethanol oxidation and drug glucuronidation in isolated hepatocytes.
The effect of extracellular Ca2+ concentration on ethanol oxidation and drug metabolism was studied in isolated rat hepatocytes. Both ethanol oxidation and drug glucuronidation showed similar dependence upon Ca2+, which was a stimulation of activity as Ca2+ was increased to physiological concentration, and inhibition at higher concentration.
D000470:Alkaloids / Q000378:metabolism*; D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D000431:Ethanol / Q000378:metabolism*; D006247:Harmine / Q000031:analogs & derivatives / Q000378:metabolism*; D066298:In Vitro Techniques; D008099:Liver / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010084:Oxidation-Reduction; D051381:Rats; D013268:Stimulation, Chemical
D000470:Alkaloids; D000431:Ethanol; C001326:harmol; D006247:Harmine; D002118:Calcium