title: A test for analgesics as an indicator of locomotor activity in writhing mice.
abstract: Marked depression of locomotor activity was observed in writhing mice given acetic acid i.p. This depression of the activity was evidenced by a squatting posture in reaction to pain. The hypoactivity was reversed dose-dependently by nonnarcotic analgesics such as acetyl-salicylic acid, aminopyrine and mefenamic acid in smaller dosages than those obtained by the conventional writhing syndrome test, and was also reversed dose-dependently by narcotic analgesics such as morphine, pethidine and codeine. Consequently, this hypoactivity test proved to be useful for analgesics screening.
mesh_terms: D000085:Acetates; D000632:Aminopyrine / Q000494:pharmacology; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D004347:Drug Interactions; D005557:Formaldehyde / Q000494:pharmacology; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects*; D009294:Narcotics / Q000494:pharmacology; D010146:Pain / Q000139:chemically induced / Q000503:physiopathology*; D013997:Time Factors
chemical_list: D000085:Acetates; D000700:Analgesics; D009294:Narcotics; D000632:Aminopyrine; D005557:Formaldehyde; D009020:Morphine