Involvement of SRS-A in the Schultz-Dale response of the guinea-pig small intestine.
1 The anaphylactic reaction of the guinea-pig ileum, the so called Schultz-Dale reaction, shows a biphasic response: a short rapid contraction followed by a partial relaxation and a slow contractile response. 2 Dose-response curves with ovalbumin as an antigen were obtained for the quick and slow contraction of this anaphylactic reaction. 3 Mepyramine (1 microgram/ml) blocked the rapid first contraction, but failed to abolish the slow one in about 50% of the animals studied. 4 The SRS-A antagonist, FPL 55712, significantly depressed the slow sustained contraction during the Schultz-Dale reaction. Disodiumcromoglycate was without effect on both phases when it was added 5 min before addition of the antigen. However, when added simultaneously with the antigen it produced a 30% suppression of the slow phase in the highest concentration used.
D000707:Anaphylaxis / Q000139:chemically induced / Q000378:metabolism / Q000503:physiopathology*; D000818:Animals; D005260:Female; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D007082:Ileum / Q000276:immunology*; D066298:In Vitro Techniques; D008297:Male; D010047:Ovalbumin / Q000276:immunology; D013189:SRS-A / Q000378:metabolism / Q000502:physiology*
D013189:SRS-A; D006632:Histamine; D010047:Ovalbumin