title: Inhibition of spinal interneuronal activity by repeated cutaneous stimulation: a possible substrate of flexor reflex habituation.
abstract: The responses of interneurones, situated in the lumbar region of the rat spinal cord, to repeated cutaneous stimulation, were studied. The main purpose of this investigation was to attempt to determine the extent to which habituation of the flexor reflex might be explained on the basis of a progressive development of inhibition. Spontaneously active interneurones, which were inhibited by cutaneous stimuli, were investigated in detail. In rats whose spinal cords were intact, the period of inhibition was shown to increase with successive stimuli. This increase in inhibition was directly related to the intensity and frequency of stimulation, occurred more rapidly during a second series of stimuli and was antagonized by strychnine. In spinal animals, an increase in the duration of the period of inhibition to repeated stimulation could not be demonstrated. In this preparation, a gradual decrease in inhibition occurred. It is tentatively concluded that inhibition of spinal interneurones, the development of which depends upon descending influences from supraspinal centres, may be partially responsible for habituation.
mesh_terms: D000818:Animals; D004558:Electric Stimulation; D006185:Habituation, Psychophysiologic / Q000187:drug effects / Q000502:physiology*; D007395:Interneurons / Q000502:physiology*; D008297:Male; D009433:Neural Inhibition; D051381:Rats; D012018:Reflex / Q000187:drug effects / Q000502:physiology*; D012867:Skin / Q000294:innervation; D013116:Spinal Cord / Q000502:physiology / Q000601:surgery; D013331:Strychnine / Q000494:pharmacology
chemical_list: D013331:Strychnine