[Correlations between the changes in the affinity of hemoglobin of oxygen and the anaerobic metabolism during muscular exercise in 20 silicotic patients (author's transl)].
This study investigated the changes in hemoglobin affinity for oxygen -- P50 standard [P50 (7.40)]; P50 in vivo (P50 IV), and 2,3-diphosphoglycerate concentration (2,3-DPG) -- and the anaerobic metabolism during a short muscular exercise in 20 silicotic patients. P50 (7.40) and 2,3-DPG remained unchanged at the end of the exercise but P50 IV increased significantly. A negative correlation was found between the increase in the arterial lactates and the increase in P50 IV. Such a shift to the right of the oxyhemoglobin dissociation curve probably improves the tissular oxygenation and can be regarded as a compensatory mechanism in patients with pulmonary impairment during exercise.
D004163:Diphosphoglyceric Acids / Q000378:metabolism; D005260:Female; D006801:Humans; D007773:Lactates / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010108:Oxyhemoglobins / Q000378:metabolism*; D005082:Physical Exertion; D011773:Pyruvates / Q000378:metabolism; D012829:Silicosis / Q000378:metabolism*
D004163:Diphosphoglyceric Acids; D007773:Lactates; D010108:Oxyhemoglobins; D011773:Pyruvates
Corrélation entre modifications de l'affinité de l'hémoglobine pour l'oxygène et métabolisme anaérobie au cours de l'exercice musculaire chez 20 silicotiques.