[Experiences with Pirenzepin in the therapy of peptic ulcers (author's transl)].
21 patients with peptic ulcers were treated with 2X25 mg Pirenzepin daily. A decrease in basal and Pentagastrin-stimulated HCl-secretion was found. Patients with duodenal ulcers (n = 12) or gastric ulcers (n = 9) became painless within 6 to 11 days. 18 ulcers healed under treatment with Pirenzepin. Patients with duodenal ulcer showed recovery sooner than patients with gastric ulcer. One year later recurrent ulcers were observed in 4 cases. Side-effects of Pirenzepin did not occur.
D000328:Adult; D000368:Aged; D001570:Benzodiazepinones / Q000627:therapeutic use*; D004341:Drug Evaluation; D004361:Drug Tolerance; D004381:Duodenal Ulcer / Q000188:drug therapy*; D005260:Female; D005750:Gastric Juice / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D010418:Pentagastrin; D010879:Piperazines / Q000627:therapeutic use*; D013276:Stomach Ulcer / Q000188:drug therapy*
D001570:Benzodiazepinones; D010879:Piperazines; D010418:Pentagastrin
Erfahrungen mit Pirenzepin bei der Ulkuskrankheit des Magens und des Duodenums.