Teratogenic risks of antiepileptic drugs in respect to the type of epilepsy.
The incidence of malformations and/or miscarriage-stillbirths was unequivocally higher in offsprings born to mothers with secondary generalized epilepsy or complex partial seizures. Although it was difficult to separate the possible role played by antiepileptic drugs from that of predisposed severity of epilepsy, the teratogenic risks due to medication appeared to be more plausible. Polypharmacy and overdose regimen should be avoided by all means especially during the earlier period of pregnancy.
D000014:Abnormalities, Drug-Induced / Q000453:epidemiology / Q000209:etiology*; D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D004827:Epilepsy / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007564:Japan; D011247:Pregnancy; D011248:Pregnancy Complications; D012306:Risk
D000927:Anticonvulsants