Non-specific stimulant activity of tyramine on isolated intestinal preparations.
The effect of tyramine on isolated organ preparations from several animal species has been studied. Contraction of the guinea-pig ileum by tyramine is due to a direct effect on histamine receptors whereas the contractile effect on the rat fundus and rabbit jejunum by tyramine is mediated through 5-hydroxytryptamine receptors. These studies indicate the variability and non-specificity of isolated organ responses and that the effects of tyramine are not limited to adrenergic systems.
D000818:Animals; D004347:Drug Interactions; D005260:Female; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D007422:Intestines / Q000187:drug effects*; D007583:Jejunum / Q000187:drug effects; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D011968:Receptors, Histamine / Q000187:drug effects; D011985:Receptors, Serotonin / Q000187:drug effects; D013045:Species Specificity; D013270:Stomach / Q000187:drug effects; D014439:Tyramine / Q000494:pharmacology*
D011968:Receptors, Histamine; D011985:Receptors, Serotonin; D014439:Tyramine