Increased plasma activities of N-acetyl-beta-D-glucosaminidase isoenzymes in human diabetes mellitus.
Plasma N-acetyl-beta-D-glucosaminidase activities are raised in maturity-onset insulin-dependent diabetic patients. Continuous gradient DEAE-cellulose column chromatography and assay of heat-stable enzyme activity both show that the activities of all isoenzymes are equally increased rather than a previously described increase of specific isoenzymes. Plasma enzyme activities are similarly increased in patients with and without diabetic retinopathy, and correlate with simultaneous plasma glucose concentrations.
D000118:Acetylglucosaminidase / Q000097:blood*; D000328:Adult; D000368:Aged; D002848:Chromatography, DEAE-Cellulose; D003920:Diabetes Mellitus / Q000201:enzymology*; D003922:Diabetes Mellitus, Type 1 / Q000201:enzymology; D006596:Hexosaminidases / Q000097:blood*; D006801:Humans; D007527:Isoenzymes / Q000097:blood*; D008297:Male; D008875:Middle Aged
D007527:Isoenzymes; D006596:Hexosaminidases; D000118:Acetylglucosaminidase