title: Moderate and extreme haemodilution in open-heart surgery: evaluation of haemolysis, cell damage and protein changes.
abstract: Clinical chemical data from patients operated upon in moderate and extreme haemodilution have been compared. Haemolysis was more pronounced during and after moderate dilution that in extreme dilution. A slight liver damage was found post-operatively after moderate dilution. Several changes were of about the same magnitude in both groups: Serum CK increased, reaching maximal activity 3-18 h after operation. An acute phase reaction of plasma proteins took place post-operatively, except that the concentration of complement C-3 dropped during the first days after operation. The serum levels of phosphate were positively correlated to several of the acute phase proteins.
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D001663:Bilirubin / Q000097:blood; D001798:Blood Proteins / Q000032:analysis*; D006348:Cardiac Surgical Procedures; D003402:Creatine Kinase / Q000097:blood; D006438:Hemodilution / Q000009:adverse effects / Q000379:methods*; D006454:Hemoglobins / Q000032:analysis; D006461:Hemolysis; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008099:Liver / Q000473:pathology*; D013997:Time Factors
chemical_list: D001798:Blood Proteins; D006454:Hemoglobins; D007770:L-Lactate Dehydrogenase; D000410:Alanine Transaminase; D003402:Creatine Kinase; D001663:Bilirubin