title: [Acute leukemia in 3 children with chronic juvenile arthritis treated with chlorambucil].
abstract: Three children out of a total of 40 who had been treated with chlorambucil for juvenile rheumatoid arthritis developed acute leukaemia. No malignancy was detected in 160 patients in those treated with steroids and/or other anti-inflammatory drugs. Chlorambucil may have induced the malignancies and its use should be avoided in rheumatoid arthritis.
mesh_terms: D000208:Acute Disease; D000477:Alkylating Agents / Q000494:pharmacology; D001171:Arthritis, Juvenile / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D002699:Chlorambucil / Q000009:adverse effects*; D002875:Chromosomes / Q000187:drug effects; D006801:Humans; D007223:Infant; D007938:Leukemia / Q000139:chemically induced*; D008297:Male
chemical_list: D000477:Alkylating Agents; D002699:Chlorambucil
vernacular_title: Leucémie aiguë chez trois enfants atteints d'arthrite chronique juvénile traités par le chlorambucil.