Relative potencies of different anti-herpes agents in the topical treatment of cutaneous herpes simplex virus infection of athymic nude mice.
Thirteen established anti-herpes compounds have been directly compared in a single assay system for their effects on the development of herpetic skin lesions, and mortality associated therewith, in athymic nude (nu/nu) mice inoculated intracutaneously with herpes simplex virus type 1 (KOS). When applied topically (at 1% in a water-soluble ointment), phosphonoacetic acid, E-5-(2-bromovinyl)-2'-deoxyuridine, acycloguanosine, and trisodium phosphonoformate emerged as the most active agents.
D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D006561:Herpes Simplex / Q000188:drug therapy*; D051379:Mice; D008819:Mice, Nude; D012874:Skin Diseases, Infectious / Q000188:drug therapy*; D013950:Thymus Gland / Q000502:physiology
D000998:Antiviral Agents