title: Thioridazine and EKG anomalies.
abstract: Acute i.v. infusion but not daily oral administration of thioridazine-HCl in the dog produced EKG anomalies similar to those reported in psychiatric patients taking this drug. Lack of EKG effects after thioridazine-5-sulfoxide infusion and presence of anomalies after thioridazine at equivalent doses suggests further evaluation of the relationship between reported plasma levels of thioridazine and its ring-sulfoxide in association with EKG changes.
mesh_terms: D000818:Animals; D004285:Dogs; D004562:Electrocardiography; D006321:Heart / Q000187:drug effects / Q000502:physiology*; D013881:Thioridazine / Q000097:blood / Q000494:pharmacology*
chemical_list: D013881:Thioridazine