[Effect of the phosphonic acid derivatives ethephon and trichlorphon on the incorporation in vivo of (14C)-acetate into cholesterol and other lipids in rats].
The effect of the phosphonic acid derivatives Ethephon and Trichlorphon on the incorporation of 14C-labelled acetate into lipids especially cholesterol was investigated. Adult Wistar rats were fed for 7 days diets containing 50 and 500 ppm, respectively, of the phosphonic acid derivatives. Both compounds caused a significant increase of the 14C-activity in lipids of serum, liver, heart, and brain. The effect of Ethephon was significantly more intense than that of Trichlorphon. The important finding was the Ethephon-induced increase of the [14C]-acetate incorporation into cholesterol which continued across all the tissues studied.
D000085:Acetates / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002784:Cholesterol / Q000096:biosynthesis*; D006321:Heart / Q000187:drug effects; D007700:Kinetics; D008055:Lipids / Q000096:biosynthesis*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D010743:Phospholipids / Q000096:biosynthesis; D051381:Rats; D014236:Trichlorfon / Q000494:pharmacology*; D014280:Triglycerides / Q000096:biosynthesis
D000085:Acetates; D008055:Lipids; D009943:Organophosphorus Compounds; D010743:Phospholipids; D014280:Triglycerides; D002784:Cholesterol; D014236:Trichlorfon; C005073:ethephon
Einfluss der Phosphonsäurederivate Ethephon und Trichlorphon auf den in vivo-Einbau von [14C]-Azetat in Cholesterol und andere Lipide der Ratte.