Ledakrin effect on free fatty acid and glycerol mobilization from epididymal adipose tissue of rat in vitro.
It was demonstrated that Ledakrin, an antitumour drug, causes mobilization of free fatty acids and glycerol from the epididymal adipose tissue of rat in vitro. The disproportion observed in the release of glycerol and free fatty acids following Ledakrin administration suggested a biphasic effect of this drug, with initial stimulation and later inhibition of the processes of lipolysis and lipogenesis. Blockade of adrenergic membrane receptors (with propranolol or regitine) abolished the lipolytic effect of Ledakrin.
D000166:Acridines / Q000494:pharmacology*; D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D003520:Cyclophosphamide / Q000494:pharmacology; D004822:Epididymis; D004837:Epinephrine / Q000494:pharmacology; D005230:Fatty Acids, Nonesterified / Q000378:metabolism*; D005990:Glycerol / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D009564:Nitracrine / Q000494:pharmacology*; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D014747:Vinblastine / Q000494:pharmacology
D000166:Acridines; D005230:Fatty Acids, Nonesterified; D014747:Vinblastine; D009564:Nitracrine; D003520:Cyclophosphamide; D011433:Propranolol; D005990:Glycerol; D004837:Epinephrine; D010646:Phentolamine