Free autogenous muscle transplantation in 5 children with urinary incontinence.
Five children with urinary incontinence were operated with a new method involving free autogenous muscle transplantation. Before transplantation a skeletal muscle (extensor brevis of the foot) is denervated and, 2 weeks later, it is transplanted and placed as a U-sling around the urethra in close contact with normally innervated muscles, which act as reinnervation sources. All patients showed improvement of continence and increasing bladder capacity from about 2 months after transplantation. Postoperative cine-micturition studies clearly demonstrated the functional properties of the transplanted muscle and estimation of urinary flow rate showed no signs of infravesical obstruction.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D009121:Muscle Denervation; D009132:Muscles / Q000637:transplantation*; D014182:Transplantation, Autologous; D014549:Urinary Incontinence / Q000628:therapy*; D014718:Vesico-Ureteral Reflux / Q000628:therapy