title: Induction of intestinal evacuation or vomition (or both) in the dog by prostaglandin F2alpha injection: clinical potential.
abstract: Different groups of dogs were given prostaglandin F2alpha IM. The dosage range was between 0.022 and 0.555 mg/kg of body weight. Defecation, including contents from the cranial portion of the large intestine, occurred in 40% to 100% of the dogs within 3.16 to 12.5 minutes after injection depending on dosage administered. Defecation (83.3% of dogs), without vomition, occurred in dogs given a dosage of 0.111 mg/kg. Emesis (87.5% of dogs) and defecation (75.0% of dogs) were observed in dogs given a dosage of greater than or equal to 0.444 mg/kg. Emesis occurred in 1.6 to 2.6 minutes after defecation in dogs given more than 0.444 mg/kg. Latency for emesis response varied between 3.2 and 11.5 minutes. The effect of the drug lasted approximately 15 minutes, with most dogs showing a single episode of defecation or vomition (or both). Besides a marked increase in respiratory rate, side effects were minor. Seemingly, prostaglandin-F2alpha may become the preferred drug for the clinical inducement of vomition and defecation in dogs.
mesh_terms: D000818:Animals; D003672:Defecation / Q000187:drug effects; D004285:Dogs; D004639:Emetics / Q000494:pharmacology; D005746:Gastric Emptying / Q000187:drug effects*; D007267:Injections; D011460:Prostaglandins F / Q000494:pharmacology*; D012119:Respiration / Q000187:drug effects; D014554:Urination / Q000187:drug effects; D014839:Vomiting / Q000139:chemically induced*
chemical_list: D004639:Emetics; D011460:Prostaglandins F