Plasma lecithin-cholesterol acyltransferase: lack of induction by phenobarbital in guinea pigs.
Compared with controls, guinea pigs ip injected by phenobarbital for 4 days displayed higher activities of two hepatic microsomial enzymes: aminopyrine N-deme-thylase and benzo(alpha)pyrene hydroxylase. In contrast plasma lecithin-cholesterol acyltransferase (LCAT) activity was not increased by phenobarbital. It then appears that like in humans, plasma LCAT does not seem inducible by phenobarbital.
D000633:Aminopyrine N-Demethylase / Q000378:metabolism; D000818:Animals; D001579:Benzopyrene Hydroxylase / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D004790:Enzyme Induction; D006168:Guinea Pigs; D008099:Liver / Q000187:drug effects; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology; D009929:Organ Size / Q000187:drug effects; D010634:Phenobarbital / Q000494:pharmacology*; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000096:biosynthesis / Q000097:blood*
D002784:Cholesterol; D001579:Benzopyrene Hydroxylase; D000633:Aminopyrine N-Demethylase; D007862:Phosphatidylcholine-Sterol O-Acyltransferase; D010634:Phenobarbital