The action of Solcoseryl on two glycolytic enzymes of several organs of the irradiated mouse.
The blood extract Solcoseryl (SO), when administered daily in i.p. injection to mice adapted to ambient temperature of 32.5 degrees C enhances within a period of 5 days the activities of the enzymes LDH and G-6-PDH of liver, kidney, testes and thymus in an oscillatory way. The changes of enzyme activity resulting from whole body irradiation with gamma-rays and exhibiting mostly a tendency towards diminution are abolished and the activities restored to values lying in between those obtained with sole SO treatment or irradiation alone, respectively, when following irradiation SO is again applied for a period of 3 days.
D000064:Acclimatization; D000183:Actihaemyl / Q000494:pharmacology*; D000818:Animals; D003037:Cobalt Radioisotopes; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism / Q000528:radiation effects*; D006019:Glycolysis / Q000528:radiation effects*; D006358:Hot Temperature; D007668:Kidney / Q000201:enzymology; D007700:Kinetics; D007770:L-Lactate Dehydrogenase / Q000378:metabolism / Q000528:radiation effects*; D008099:Liver / Q000201:enzymology; D008297:Male; D051379:Mice; D013737:Testis / Q000201:enzymology; D013950:Thymus Gland / Q000201:enzymology; D014020:Tissue Extracts / Q000494:pharmacology*
D003037:Cobalt Radioisotopes; D014020:Tissue Extracts; D000183:Actihaemyl; D007770:L-Lactate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase