A detoxification scheme for liver assist utilizing plasmapheresis, bioincompatible sorbents and dialysis.
The rationale behind the design of a sorbent-based detoxification system for use as a liver assist is presented. A membrane-based plasmapheresis system giving high plasma flows (greater than 40 ml/min) with maximum transmission of albumin makes this concept feasible.
D000327:Adsorption; D001187:Artificial Organs; D001672:Biocompatible Materials; D002244:Carbon; D006464:Hemoperfusion; D006501:Hepatic Encephalopathy / Q000378:metabolism; D006801:Humans; D008099:Liver; D008567:Membranes, Artificial; D010956:Plasmapheresis; D006435:Renal Dialysis; D014118:Toxins, Biological / Q000097:blood / Q000378:metabolism
D001672:Biocompatible Materials; D008567:Membranes, Artificial; D014118:Toxins, Biological; D002244:Carbon