Barium ions block the acetylcholine evoked slow H-response in the neurones of Helix pomatia L.
The effects of barium ions on slow acetylcholine (Ach) H receptor activated hyperpolarization has been studied. The results provide evidence of a sensitive and reversible blocking action of Ba2+ on the involved potassium conductance. 3-Aminopyridine (3-AP) also attenuated the slow H-response by 50%, showing partial effectiveness. TEA+ sensitively inhibited the Ach evoked hyperpolarization interacting with the receptors.
D000632:Aminopyrine / Q000494:pharmacology; D000818:Animals; D001464:Barium / Q000494:pharmacology*; D004553:Electric Conductivity; D005724:Ganglia / Q000187:drug effects*; D006372:Helix, Snails; D007473:Ion Channels / Q000187:drug effects*; D008564:Membrane Potentials / Q000187:drug effects; D010276:Parasympatholytics; D013757:Tetraethylammonium Compounds / Q000494:pharmacology
D007473:Ion Channels; D010276:Parasympatholytics; D013757:Tetraethylammonium Compounds; D000632:Aminopyrine; D001464:Barium