Formation and synthesis of 3'-t-butyltyrosine.
During acidolysis by TFA of the t-butyl protecting group from Z-Tyr(But) or from Ser (But) in the presence of tyrosine, C-t-butylation occurred in the aromatic nucleus in Z-Tyr or tyrosine, respectively, to an extent of 0.5-1.0%. CF3COOBut formed during the acidolysis slowly C-t-butylates tyrosine. Tyr(3'But) is formed. The synthesis of Tyr (3'But) . HCl is described.
D055598:Chemical Phenomena; D002621:Chemistry; D013057:Spectrum Analysis; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis
C024096:3'-tert-butyltyrosine; D014443:Tyrosine