Effect of psychotropic drugs on the development of experimental gastric ulcer produced by different stress-inducing factors in rats.
The anti-ulcer activity of three different doses (1/10, 1/30 and 1/90 of LD50) of imipramine, amitryptyline, chlorpromazine, amphetamine, ephedrine, chlordiazepoxide and meprobamate was studied in two types of stress-produced gastric ulcers in rats. It was found that these drugs given in doses of 1/10 or 1/30 LD50 inhibited in the same degree the development of gastric ulcer-produced by the method of Senay, in spite of differences in their psychotropic activity. On the other hand, when the method of Rossi was used for ulcer production the ulcer-preventing activity of these drugs has been varied. Thymoleptics were most effective and ataractics least effective against ulcers produced by the method of Rossi.
D000639:Amitriptyline / Q000627:therapeutic use; D000661:Amphetamine / Q000627:therapeutic use; D000818:Animals; D002707:Chlordiazepoxide / Q000627:therapeutic use; D002746:Chlorpromazine / Q000627:therapeutic use; D004809:Ephedrine / Q000627:therapeutic use; D007099:Imipramine / Q000627:therapeutic use; D007103:Immobilization; D008297:Male; D008620:Meprobamate / Q000627:therapeutic use; D011619:Psychotropic Drugs / Q000627:therapeutic use*; D051381:Rats; D013276:Stomach Ulcer / Q000209:etiology / Q000517:prevention & control*; D013312:Stress, Physiological / Q000150:complications*
D011619:Psychotropic Drugs; D000639:Amitriptyline; D002707:Chlordiazepoxide; D008620:Meprobamate; D000661:Amphetamine; D004809:Ephedrine; D007099:Imipramine; D002746:Chlorpromazine