Effects on the immune response of rats rendered leukopenic with 4-(p-chlorophenylthio)-butanol (W-2719) and its major metabolites.
4-(p-Chlorophenylthio)butanol (W-2719) and its major acid metabolites W-2718 (butyrate) and W-2683 (acetate), when administered as drug-diet admixtures to male and female Sprague-Dawley rats for five weeks (approximately 200.0 mg/kg/day), induced a marked leukopenia. Effect on the primary and secondary immune responses to bovine serum albumin (BSA) immunization was that of suppression as evidenced by strikingly reduced passive hemagglutination serum titers.
D000818:Animals; D000440:Butanols / Q000494:pharmacology*; D002417:Cattle; D005260:Female; D006386:Hemagglutination Tests; D007109:Immunity / Q000187:drug effects*; D007114:Immunization; D007970:Leukopenia / Q000139:chemically induced / Q000276:immunology*; D008297:Male; D051381:Rats; D012710:Serum Albumin, Bovine / Q000276:immunology; D012737:Sex Factors; D013997:Time Factors
D000440:Butanols; D012710:Serum Albumin, Bovine; C020962:4-(p-chlorophenylthio)butanol