[The effect of repeated applications of carbutamide on the embryonic development of the rat (author's transl)].
The present paper will check the effects of repeated applications of the oral "antidiabeticum" Carbutamide (substitute of the "sulfonylurea") on the embryonic development of wistar rats. The agent was given the pregnant animal by the means of a throat sonde at the 5th, 6th and 7th day post coitum suspended in Tween 80 in a dosage of 800 mg/kg bodyweight. In order to value the intrauterine development the following parameters were used: mean implantation rate, resorptions rate, bodyweight of fetuses, statemend of animalies by an accurate inspection of the body surface shape, of the skeleton and the inner organs. The rates of implantation do not differ from that of the control group. The rate of resorption increases dependend on the beginning of the treatment. The later the treatment begins the higher the resorptions rate. The body weight of surviving fetuses is diminished strongly. Damage of the skeleton appears as the presence of 14th ribs at one or each side or as ossifications at the 7th neck vertebra (neck rib). Also this results depend on the beginn of the treatment.
D000014:Abnormalities, Drug-Induced; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001842:Bone and Bones / Q000002:abnormalities; D002271:Carbutamide / Q000494:pharmacology*; D010064:Embryo Implantation / Q000187:drug effects; D020964:Embryo Loss / Q000139:chemically induced; D004622:Embryo, Mammalian / Q000187:drug effects*; D005260:Female; D005328:Fetal Viability / Q000187:drug effects; D011247:Pregnancy; D051381:Rats; D013997:Time Factors
D002271:Carbutamide
Die Wirkung der mehrmaligen Gaben von Carbutamid auf die Keimlingsentwicklung der Ratte.