Studies on the metabolism and toxicity of dinitrotoluenes. Toxicological study of 2,4-dinitrotoluene (2, 4-DNT) in rats in long term feeding.
2, 4-Dinitrotoluene (2, 4-DNT) was incorporated at the level of 0.5% in a standard commercial diet and fed ad lib. to male rate for 6 months. Significant changes were noted in the body weight, organ weight, behavior, mortality, and biochemical analysis of blood and serum of rats ingesting 2, 4-DNT. Furthermore, it was found that the ingestion of 2, 4-DNT affected on the activities of drug metabolizing enzymes in liver microsomes.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D004032:Diet; D004136:Dinitrobenzenes / Q000378:metabolism / Q000633:toxicity*; D004798:Enzymes / Q000097:blood; D008297:Male; D008706:Methemoglobin / Q000378:metabolism; D009578:Nitrobenzenes / Q000633:toxicity*; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D013997:Time Factors
D004136:Dinitrobenzenes; D004798:Enzymes; D009578:Nitrobenzenes; C016403:2,4-dinitrotoluene; D008706:Methemoglobin