Deleterious effect of short-term exposure to Coca-Cola on rats.
Semiacute toxicity of cola fluid, Coca-Cola, conducting for approximately a month in rats, was studied. A trend of cariogenicity of Coca-Cola was strongly indicated. When the fluid was given ad libitum, decarbonized Coca-Cola and carbohydrate solution, consisted 8% of glucose and 3.5% of sugar and then adjusted pH to 2.4 with oxalic acid, were consumed 2 to 3 times greater than the control (water). A hyperuresis was observed as the result of great consumption of liquid, but no liver nor kidney degeneration was observed by histopathological examination. The diet consumption of the groups of Coca-Cola and carbohydrate solution was approximately a half of the control, water. However, when a complete diet was given, no physiological difference in time was observed, except in diarrhea and depression of hair gloss in Coca-Cola group.
D000818:Animals; D001628:Beverages / Q000633:toxicity*; D001777:Blood Coagulation / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002136:Calcium, Dietary; D002253:Carbonated Beverages / Q000633:toxicity*; D003731:Dental Caries / Q000139:chemically induced; D004032:Diet; D004435:Eating / Q000187:drug effects; D007668:Kidney / Q000473:pathology; D008099:Liver / Q000473:pathology; D008297:Male; D008903:Minerals / Q000097:blood; D051381:Rats; D013997:Time Factors
D002136:Calcium, Dietary; D008903:Minerals