Effect of furosemide on the ionic composition of the arterial wall.
Furosemide decreased the intracellular H2O, Cl and K content and Cl concentration of dog carotid arteries incubated in normal or high K Krebs (123 mM). Cl loss exceeded K loss in normal Krebs but was of the same magnitude in high K Krebs. The findings are compatible with the inhibition of a neutral K-Cl coupled uptake.
D000818:Animals; D001158:Arteries / Q000187:drug effects* / Q000378:metabolism; D002712:Chlorides / Q000378:metabolism*; D004285:Dogs; D005665:Furosemide / Q000494:pharmacology*; D066298:In Vitro Techniques; D011188:Potassium / Q000378:metabolism; D014882:Water-Electrolyte Balance / Q000187:drug effects
D002712:Chlorides; D005665:Furosemide; D011188:Potassium