Genetic basis of acquired C4 deficiency.
A study of the family of a patient who had an SLE-like syndrome and an extremely low serum C4 revealed an inheritance of C4 types and HLA region markers which indicated that the patient had 60--70% of "normal" C4 level prior to the onset of disease. Thus the extremely low C4 level during her disease may result from a combination of genetically determined low normal C4 and increased consumption/hyposynthesis secondary to her SLE.
D000328:Adult; D003175:Complement C2 / Q000235:genetics; D003181:Complement C4 / Q000172:deficiency* / Q000235:genetics; D005260:Female; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics / Q000276:immunology*; D010375:Pedigree
D003175:Complement C2; D003181:Complement C4; D006680:HLA Antigens