Interaction of mestranol with taurocholate uptake by isolated rat hepatocytes.
Cellular uptake interactions between mestranol and taurocholate at concentrations between 50 and 1000 microM in the medium were studied in isolated hepatocytes. Rat liver cells exposed to medium containing mestranol and taurocholate attained up to twice as large a concentration of mestranol as those exposed to mestranol without the presence of the bile acid in medium. In contrast, taurocholate concentration in cells exposed simultaneously to taurocholate and mestranol was one fourth of the concentration in cells exposed to taurocholate alone.
D000818:Animals; D066298:In Vitro Techniques; D008099:Liver / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008656:Mestranol / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D013656:Taurocholic Acid / Q000378:metabolism*; D013997:Time Factors
D013656:Taurocholic Acid; D008656:Mestranol