Effect of whole body irradiation on different tissues. Experiments with 14C leucine in the rat.
The uptake and elimination of 14C leucine were analysed in controls and in rats irradiated 2 h before injection with 8 Gy whole-body irradiation. Plasma, small intestine, kidney and skin were assayed after homogenization for TCA soluble activity curves. In highly differentiated tissues with poor proliferative activity and low protein turnover, the uptake and elimination of the tracer did not appear to be affected by irradiation. In the small intestine differences between control and irradiated animals seemed significant.
D000818:Animals; D001345:Autoradiography; D005260:Female; D007421:Intestine, Small / Q000378:metabolism / Q000528:radiation effects; D007668:Kidney / Q000378:metabolism / Q000528:radiation effects; D007930:Leucine / Q000097:blood / Q000378:metabolism*; D010306:Parotid Gland / Q000378:metabolism / Q000528:radiation effects; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000175:diagnosis* / Q000378:metabolism; D051381:Rats; D012867:Skin / Q000378:metabolism / Q000528:radiation effects; D014238:Trichloroacetic Acid / Q000378:metabolism*
D014238:Trichloroacetic Acid; D007930:Leucine