Some histochemical and electrophysiological effects of isatin.
Qualitative and semiquantitative histochemical investigations of acetylcholinesterase after a single or repeated administration of isatin, 160 mg/kg ip once or daily for 8 consecutive days have revealed a significant decrease of the histochemical reaction for acetylcholinesterase in chronically treated rats. The cholinergic effect of isatin was tested in the electrophysiological experiment after a single dose of 160 mg/kg isatin and was partially antagonized by atropine.
D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001921:Brain / Q000033:anatomy & histology / Q000187:drug effects*; D003344:Cortical Synchronization; D004569:Electroencephalography; D004594:Electrophysiology; D006651:Histocytochemistry; D007211:Indoles / Q000494:pharmacology*; D007510:Isatin / Q000494:pharmacology*; D008297:Male; D010775:Photic Stimulation; D051381:Rats; D011999:Recruitment, Neurophysiological / Q000187:drug effects; D013997:Time Factors
D007211:Indoles; D001285:Atropine; D007510:Isatin; D000110:Acetylcholinesterase