title: Nonlinear regression on multiple-dose data.
abstract: The examples are given to show how Metzler's nonlinear regression program can be used to estimate parameters in a model with multiple dosing. The model of one example is a set of equations involving sums of exponentials, whereas the other model is a set of differential equations reflecting first order absorption and Michaelis-Menten excretion. In both cases no data were given in one of the dosing intervals.
mesh_terms: D003201:Computers; D007700:Kinetics; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D012044:Regression Analysis
chemical_list: D004364:Pharmaceutical Preparations