Histopathological reactivity of carotid arteries of normotensive Sprague-Dawley vs spontaneously hypertensive rats to ligation injury.
The common carotid arteries of normotensive non-arteriosclerotic Sprague-Dawley (S-D) rats, mildly hypertensive but arteriosclerotic breeder S-D rats, severely hypertensive but non-arteriosclerotic virgin spontaneously hypertensive rats (SHR), and severely hypertensive breeder SHR were ligated to induce injury. Three weeks post-ligation, the animals were killed and histopathological sections of the ligated artery demonstrated myointimal proliferation without occlusion in the normotensive S-D rats but myointimal proliferation with occlusion in the severely hypertensive SHR. Breeder S-D rats with moderate hypertension manifested a high incidence of total occlusion by combined myointimal proliferation and thrombosis. Severely hypertensive breeder SHR manifested a high incidence of massive thrombi containing cholesterol clefts causing total occlusion of the injured artery. It is suggested that the severity of the hypertension and the hormonal-metabolic milieu conditions the morphologic response of the arterial wall to injury.
D000818:Animals; D001161:Arteriosclerosis / Q000473:pathology; D002339:Carotid Arteries / Q000473:pathology*; D020212:Carotid Artery Injuries; D002341:Carotid Artery Thrombosis / Q000473:pathology; D002784:Cholesterol / Q000378:metabolism; D005260:Female; D005352:Fibromuscular Dysplasia / Q000473:pathology; D006973:Hypertension / Q000473:pathology*; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000473:pathology; D051381:Rats
D002784:Cholesterol