Lophozozymus pictor toxin: a potent inhibitor of synaptosomal GABA uptake.
A partially purified toxin obtained from the coral reef crab, Lophozozymus pictor was found to be a potent inhibitor of Na+-dependent [14C]-GABA uptake by rat brain synaptosomes. Inhibition was potentiated in the presence of external K+. The I50 value for the toxin was found to be in the region of 10 microgram/ml at a GABA concentration of 2 microM. The inhibition showed substrate competition.
D000818:Animals; D001180:Arthropod Venoms / Q000494:pharmacology*; D003386:Brachyura; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D003864:Depression, Chemical; D009498:Neurotoxins; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D012964:Sodium / Q000494:pharmacology; D013574:Synaptosomes / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D001180:Arthropod Venoms; D009498:Neurotoxins; D005680:gamma-Aminobutyric Acid; D012964:Sodium; D011188:Potassium