title: The treatment of atrophic vaginal conditions with Ortho-Gynest: a pilot study.
abstract: A clinical study was undertaken, in twenty-four patients with atrophic vaginal changes, to assess the efficacy and the acceptability of treatment with Ortho-Gynesi vaginal suppositories, which have as their active constituent the naturally occurring substance oestriol. A regenerative effect on the vaginal epithelium could be objectively demonstrated by an increase in the proportion of superficial cells following treatment. Changes in the vaginal epithelium were accompanied by a diminution in the incidence of infection and inflammation. Subjective complaints such as dyspareunia, pruritus and kraurosis vulvae, which could also be ascribed to a relative oestrogen deficiency, responded well to treatment.
mesh_terms: D000368:Aged; D001284:Atrophy / Q000188:drug therapy; D004964:Estriol / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D008875:Middle Aged; D013488:Suppositories; D014621:Vagina / Q000187:drug effects / Q000473:pathology*
chemical_list: D013488:Suppositories; D004964:Estriol