[Study of transplacental transmission of beta-lactam antibiotics (author's transl)].
The authors present the results of the study of transplacental transfer of 3 recent beta lactam antibiotics: amoxicillin, cephradin and cefoxitin. The experiment was carried out in 37 pregnant women who had a premature rupture of membranes or who were undergoing a cesarean section. In these patients antibiotherapy was indicated in view of a possible superinfection. The results of the study show a worthwhile transplacental penetration of the 3 drugs tested. The concentrations achieved in umbilical cord blood and amniotic fluid increase with time and finally exceed the levels measured in maternal blood, after a period of time varying from 2 to 4 hours according to the drug and the route of administration.
D000653:Amniotic Fluid / Q000032:analysis; D000658:Amoxicillin / Q000378:metabolism*; D002440:Cefoxitin / Q000378:metabolism*; D002511:Cephalosporins / Q000378:metabolism*; D002515:Cephradine / Q000378:metabolism*; D005260:Female; D005312:Fetal Blood / Q000032:analysis; D005322:Premature Rupture of Fetal Membranes / Q000150:complications; D006801:Humans; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000209:etiology / Q000517:prevention & control; D013997:Time Factors
D002511:Cephalosporins; D002440:Cefoxitin; D000658:Amoxicillin; D002515:Cephradine
Etude du passage transplacentaire des bêta-lactamines.