title: [Digitalis toxicity and digoxin blood levels in children (author's transl)].
abstract: Digoxin serum levels in 41 children with clinical and/or ECG symptoms of digitoxicity were determined by radioimmunoassay and compared to the normal values. 54% of the cases showed a good relationship between clinical and/or ECG signs of toxicity and digoxin levels; on the contrary, 29% of patients exhibited only clinical and/or ECG signs of toxicity with normal digoxin levels and 17% of patients had high digoxin levels without signs of toxicity. The significance and possible causes of this relative discrepancy are discussed.
mesh_terms: D000328:Adult; D001145:Arrhythmias, Cardiac / Q000188:drug therapy*; D009202:Cardiomyopathies / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D004071:Digitalis Glycosides / Q000506:poisoning*; D004077:Digoxin / Q000097:blood / Q000506:poisoning* / Q000627:therapeutic use; D006330:Heart Defects, Congenital / Q000188:drug therapy*; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D011863:Radioimmunoassay
chemical_list: D004071:Digitalis Glycosides; D004077:Digoxin
vernacular_title: Tossicita' digitalica e digitalemia in eta' pediatrica.