Does dopamine predispose to gastroesophageal reflux?
In the American opossum dopamine causes a dose-dependant fall in the lower esophageal sphincter (LES) pressure. The effect in man is unknown. Therefore, the effect of two dosages of dopamine (1 mcg.kg-1 body weight.minute-1 and 5 mcg.kg-1 body weight.minute-1) was studied in ten healthy volunteers by pullthrough manometry. The results show that neither dopamine nor normal saline solution as a control changed LES pressure which is an important determinant of gastroesophageal sphincter competence. Thus, dopamine in clinically used doses does not appear to predispose to gastroesophageal reflux.
D000328:Adult; D004298:Dopamine / Q000008:administration & dosage / Q000494:pharmacology*; D004943:Esophagogastric Junction / Q000187:drug effects; D005260:Female; D005764:Gastroesophageal Reflux / Q000139:chemically induced*; D006801:Humans; D008297:Male; D012965:Sodium Chloride / Q000008:administration & dosage; D013997:Time Factors
D012965:Sodium Chloride; D004298:Dopamine