[Effect of aflatoxin B 1 on respiration and oxidative phosphorylation in the rabbit. II. Research on cardiac and renal mitochondria].
The effect of various concentrations of aflatoxin B1 (AB1) is studied "in vitro" on heart (HM) and kidney mitochondria of rabbit (KM). AB1 inhibits (4 x 10(-4)M) the respiratory rate up to a maximum 50-35% in HM and 28-35% in KM by glutamate and succinate as substrates respectively, but it does not uncouple oxidative phosphorylation nor does it inhibit site III (ascorbate + TMPD). The inhibited site appears to be between cytochromes b and c (c1). AB1 seems to be easily transported across heart mitochondrial membrane. The relevance of these findings to liver cell necrosis promoted by aflatoxin is discussed.
D000348:Aflatoxins / Q000494:pharmacology*; D000818:Animals; D006321:Heart / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D008929:Mitochondria, Heart / Q000187:drug effects* / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D011817:Rabbits
D000348:Aflatoxins
Effetto della aflatossina B1 sulla respirazione e fosforilazione ossidativa nel coniglio--Nota II:Ricerche sui mitocondri cardiaci e renal.