Relationship between blood flow and radiostrontium uptake in the healing bone fracture.
The healing of a diaphyseal tibia fracture was followed in the rat. Callus formation, blood flow and Sr-85 uptake were assessed by a ratio comparison of the fractured to the contralateral side. No correlation was found between blood flow and Sr-85 deposition in the callus and the adjacent bone of the same extremity. It is concluded that the deposition of a radiopharmaceutical in bone is primarily related to the presence of calcifiable organic bone matrix and only secondarily to the bone formation rate and to variations in the local blood flow.
D000818:Animals; D005269:Femur / Q000000981:diagnostic imaging; D005596:Fractures, Closed / Q000000981:diagnostic imaging; D008297:Male; D011877:Radionuclide Imaging; D051381:Rats; D012039:Regional Blood Flow; D013326:Strontium Radioisotopes; D013977:Tibia / Q000098:blood supply*; D013978:Tibial Fractures / Q000000981:diagnostic imaging*; D014945:Wound Healing
D013326:Strontium Radioisotopes