HLA and pollinosis.
Sixty-two patients were selected who suffered from seasonal pollen-induced bronchial asthma and rhinitis. Histocompatibility antigen typing was carried out with a panel of 70 antisera (Behringwerke) of 33 HLA specificities. The results obtained at locus A of the most representative by percent phenotypic frequency of the HLA studies shows a decreased frecuency of HLA-A11. The phenotyic frequencies of the most representative HLA of B locus in the group of patients shows an increase in the frequency of HLA-B8. This represents 22.6% compared with 9.1% of the controls, which is definitely significant. The results obtained in a study of the haplotype frequency of three combinations of HLA antigens, in a group of allergic patients compared with the controls shows that the frequency of the haplotype A1 B8 is greater in the allergic patients than in the control group, a statistically significant finding. As regards the other two haplotypes A2 B12 and A3 B7, the respective results of the comparison were not significant in the first and marginally significant in the second. Even these few studied cases demonstrate the predominance of HLA-B8 in atopic or hyperreactive states. As regards the A1 B8 haplotype, we also find a slightly increased occurrence, in agreement with the literature. This suggests that the hyperergic response might be associated with the presence of the A1 B8 haplotype.
D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D006801:Humans; D008297:Male; D011058:Pollen / Q000276:immunology*; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology*; D012703:Serotyping
D006680:HLA Antigens