Vagal bradycardia produced by microinjections of morphine-like drugs into the nucleus ambiguus in anaesthetized dogs.
The site in the dog medulla oblongata where fentanyl or met-enkephalinamide produced vagal bradycardia was determined using microinjections. The nucleus ambiguus was found to be a selective and highly sensitive area for the vagal bradycardia.
D000818:Animals; D004285:Dogs; D004558:Electric Stimulation; D004723:Endorphins / Q000494:pharmacology*; D004745:Enkephalins / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects; D007267:Injections; D008297:Male; D008526:Medulla Oblongata / Q000502:physiology*; D008845:Microinjections; D013153:Splanchnic Nerves / Q000187:drug effects; D014630:Vagus Nerve / Q000502:physiology*
D004723:Endorphins; D004745:Enkephalins; D005283:Fentanyl