Embryotoxicity and teratogenicity of styrene and styrene oxide on chick embryos enhanced by trichloropropylene oxide.
The effects of TCPO (trichloropropylene oxide) on the embryotoxicity and teratogenicity of styrene and styrene oxide and chick embryos were investigated. The compounds were injected into the air space of the eggs in a total volume of 25 microliter on the third day of embryogenesis. TCPO increased embryotoxicity and teratogenicity of styrene and styrene oxide. Our results present evidence that the epoxides possess embryotoxic and teratogenic properties in chick embryos.
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000818:Animals; D002642:Chick Embryo / Q000187:drug effects*; D004852:Epoxy Compounds / Q000633:toxicity*; D004988:Ethers, Cyclic / Q000633:toxicity*; D006843:Hydrocarbons, Chlorinated / Q000494:pharmacology*; D013723:Teratogens; D014239:Trichloroepoxypropane / Q000494:pharmacology*
D004852:Epoxy Compounds; D004988:Ethers, Cyclic; D006843:Hydrocarbons, Chlorinated; D013723:Teratogens; D014239:Trichloroepoxypropane; C013690:styrene oxide