"In situ" variation of folic acid and dihydrofolate reductase in the caudate nucleus in the ageing process.
In bovine caudate nucleus of young animal, a folic acid-positive reaction was found in the perikarya and in the neuroglia in parallel with a high dihydrofolate reductase activity in the nerve cells. In old animals, folic acid increased in neurons, neuroglia and some nerve cell processes; the folate enzyme was markedly decreased in neurons and increased neuroglia NADH2-cytochrom-C-reductase activity was strongly positive in nerve cells in young and old animals.
D000375:Aging; D000818:Animals; D002417:Cattle; D002421:Caudate Nucleus / Q000201:enzymology*; D005492:Folic Acid / Q000378:metabolism*; D009245:NADH Dehydrogenase / Q000378:metabolism; D009474:Neurons / Q000201:enzymology; D013762:Tetrahydrofolate Dehydrogenase / Q000378:metabolism*
D005492:Folic Acid; D013762:Tetrahydrofolate Dehydrogenase; D009245:NADH Dehydrogenase