A circulating humoral pressor agent in Dahl S rats with salt hypertension.
1. In Dahl S rats becoming hypertensive while on a diet of high NaCl content there appears to be a blood-borne humoral agent which produces vasoconstriction in a bioassay using the isolated hindquarters of rats. 2. This vasoconstrictor effect strongly suggests the presence of a humoral pressor agent or the lack of a vasodilator agent in the blood of hypertensive S rats. 3. The vasoconstrictor effect is not due to high renin concentrations. 4. This humoral vasoconstrictor action could partly account for the high vascular resistance in the hypertensive S rat.
D000818:Animals; D001681:Biological Assay; D001794:Blood Pressure; D006973:Hypertension / Q000139:chemically induced / Q000503:physiopathology*; D051381:Rats; D012965:Sodium Chloride; D013045:Species Specificity; D014655:Vascular Resistance; D014662:Vasoconstrictor Agents / Q000097:blood*
D014662:Vasoconstrictor Agents; D012965:Sodium Chloride