title: Modification of cardiac function by synchronized oscillating acceleration.
abstract: The sensitivity of selected cardiovascular (CV) responses to the physical stressor of External whole-body oscillating Acceleration Synchronized with the Electrocardiogram (EASE) was analyzed in 8 chronically instrumented tranquilized dogs. A sinusoidal acceleration wave form was imposed on the supine animals along the spinal (+/- Gz) axis at a constant amplitude of +/- 0.75 G, and a frequency equal to the paced-heart frequency (2--3 Hz). When the peak force was positive in early systole, and negative in early diastole, changes in myocardial oxygen consumption (MVo2, + 8%), mean coronary flow (MCF, + 8%), stroke volume (SV, + 15%), cardiac work (CW, + 19%) and the time derivative of left ventricular pressure (dP/dt, + 18%) were minimal in comparison to nonoscillatory control values. When the peak force was positive in early diastole and negative in late diastole and early systole, changes in MVo2 (+ 41%), MCF (+ 39%), SV (+ 33%), CW (+ 50%), and dP/dt (+ 31%) were maximal. Thus the capability of EASE to produce a range of desired sustained CV responses provides a basis for its potential diagnostic/therapeutic applications.
mesh_terms: D000054:Acceleration; D000818:Animals; D001696:Biomechanical Phenomena; D003326:Coronary Circulation; D003971:Diastole; D004285:Dogs; D006321:Heart / Q000502:physiology*; D006334:Heart Function Tests; D009206:Myocardium / Q000378:metabolism; D010101:Oxygen Consumption; D013318:Stroke Volume; D013599:Systole