Growth of Leishmania donovani amastigotes in a continuous macrophage-like cell culture.
The feastibility of using a macrophage-like murine tumor cell as a host for Leishmania donovani was investigated. This cell line, designated P388D1, rapidly phagocytized amastigotes and supported their intracellular replication. It can serve as a model "host" without the inherent limitations of primary macrophage cultures.
D000818:Animals; D002455:Cell Division; D002460:Cell Line; D007891:Leishmania / Q000254:growth & development* / Q000502:physiology / Q000648:ultrastructure; D008223:Lymphoma; D008264:Macrophages; D051379:Mice; D010587:Phagocytosis