title: Intravesical lignocaine and detrusor instability.
abstract: The effect of intravesical lignocaine solution on detrusor instability of mixed aetiology was examined in 20 patients; 40 ml of 1% lignocaine solution with 40 ml of 8.4% sodium bicarbonate solution was instilled into the bladder. This produced increased bladder capacity in 19, altered bladder sensation in 9, changed the character of the cystometrogram in 9, and lowered the maximum detrusor pressure during bladder filling in 16. The symptomatic effect of lignocaine was short-lived in all but one patient in whom it lasted 24 h. The possible mechanism of this inhibitory effect on bladder function is discussed.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011312:Pressure; D001743:Urinary Bladder / Q000187:drug effects / Q000503:physiopathology; D001745:Urinary Bladder Diseases / Q000188:drug therapy* / Q000503:physiopathology; D001750:Urinary Bladder, Neurogenic / Q000188:drug therapy; D014549:Urinary Incontinence / Q000503:physiopathology / Q000517:prevention & control*; D014563:Urodynamics
chemical_list: D008012:Lidocaine