title: Substance P afferents from the habenula innervate the dorsal raphe nucleus.
abstract: The lateral habenula nuclei of the diencephalon innervate the median and dorsal raphe nuclei of the brainstem. Habenula lesions lead to decreased substance P levels in the dorsal but not median raphe within 24 hours. From this data, we propose a peptidergic innervation of the dorsal raphe nucleus by the habenula nuclei.
mesh_terms: D000344:Afferent Pathways / Q000033:anatomy & histology / Q000201:enzymology; D000818:Animals; D001933:Brain Stem / Q000033:anatomy & histology*; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D005968:Glutamate Decarboxylase / Q000378:metabolism; D008297:Male; D009410:Nerve Degeneration; D011903:Raphe Nuclei / Q000033:anatomy & histology* / Q000201:enzymology; D051381:Rats; D013373:Substance P / Q000378:metabolism*; D013788:Thalamus / Q000033:anatomy & histology* / Q000201:enzymology
chemical_list: D013373:Substance P; D002795:Choline O-Acetyltransferase; D005968:Glutamate Decarboxylase