Mean steady-state plasma concentrations of labetalol in patients undergoing antihypertensive therapy.
1 Mean steady-state plasma concentrations of labetalol (labetalol Css) in 17 hypertensive patients undergoing chronic treatment with this drug, have been examined in relation to dose, fall in BP, and beta-blockade. 2 A significant relationship (rs = 0.81, P less than 0.001) was observed between labetalol Css and daily dose. 3 No correlation was found between labetalol Css and antihypertensive response. 4 In thirteen patients, there seemed to be significant relationship between labetalol Css and beta-blockade (rs = 0.72, P less than 0.005). In three patients, the degree of beta-blockade was disproportionate to the drug concentration.
D000328:Adult; D004305:Dose-Response Relationship, Drug; D004983:Ethanolamines / Q000097:blood*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D007700:Kinetics; D007741:Labetalol / Q000097:blood* / Q000627:therapeutic use; D008297:Male; D010919:Placebos; D013997:Time Factors
D004983:Ethanolamines; D010919:Placebos; D007741:Labetalol