Incorporation studies of nucleic acid precursors in gastric cancer: an attempt in individualized chemotherapy.
Measurements of the rate of incorporation of radioactively labeled nucleic acid precursors into the DNA and RNA of gastric carcinoma cell suspensions indicated variable rates of proliferation for the tumors. The rate of incorporation generally correlates to the cytological level of differentiation of the carcinoma. Reduced differentiation of the tumors showed a corresponding increase in the rate of proliferation. Knowing the proliferation-dependent effect of most cytostatica, this results in a resistance to cytostatica of highly differentiated gastric cancers. The nucleic acid synthesis of proliferatively active tumors could only be partially inhibited by the cytostatica tested (5-fluorouracil, adriamycin). Carcinomas with metabolic possibility for compensation of the active mechanism of the cytostatica were biochemically resistant. Due to the resulting methodical problems and unaccountable patient-dependent causes of resistance, a conclusive statement about cytostatica-sensitive tumors is difficult to make in incorporation studies.
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002454:Cell Differentiation; D002455:Cell Division; D004273:DNA, Neoplasm / Q000096:biosynthesis*; D004351:Drug Resistance; D006801:Humans; D009694:Nucleic Acid Precursors / Q000378:metabolism*; D012334:RNA, Neoplasm / Q000096:biosynthesis*; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000378:metabolism*
D000970:Antineoplastic Agents; D004273:DNA, Neoplasm; D009694:Nucleic Acid Precursors; D012334:RNA, Neoplasm