Correlation between the spermicidal activity and the haemolytic index of certain plant saponins.
The haemolytic index, the spermicidal efficacy and the effect on the vaginal mucosa of some plant saponins were determined. It was proved that a certain correlation exists between the haemolytic index and the spermicidal efficacy of these saponins. Saponin of Gypsophila paniculata was proved to be relatively superior when used in aqueous solution or when formulated in polyethylene glycol ointment base.
D000818:Animals; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004339:Drug Compounding; D005260:Female; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D007509:Irritants; D008297:Male; D011817:Rabbits; D012503:Saponins / Q000008:administration & dosage / Q000494:pharmacology*; D013089:Spermatocidal Agents; D014621:Vagina / Q000187:drug effects; D014622:Vaginal Creams, Foams, and Jellies
D007509:Irritants; D012503:Saponins; D013089:Spermatocidal Agents; D014622:Vaginal Creams, Foams, and Jellies