title: Bursa of Fabricius--mitotic index in the follicles of immunized and non-immunized chicks (Gallus domesticus).
abstract: The mitotic index in the cortical compartment of the follicles of the bursa of Fabricius from chicks immunized with sheep red blood cells (SRBC) is always higher when compaired with non-immunized ones. This mitotic index reachs its maximum 6 days after the SRBC injection, coincident with the highest serum antibody titer. The mitotic activity in the cortex of the follicles of the bursa of Fabricius is always higher than that of the medulla during the postembryonic development of chickens (PROCHAZKA, RODAK, KREJCI 1967). Otherwise it is almost established that the cortex is a zone of continuous lymphocyte proliferation, not occuring the same with the medulla. In addition these bursal histological structures are considered as 2 distinct compartments (GROSSI et al. 1974). The purpose of this paper is to study the response in the mitotic index of the cortical and medullary compartments of the follicles of the bursa of immunized and non-immunized chicks. To correlate possible changes in the mitotic index with circulating antibody levels, the serum antibody titer from the same birds was also recorded.
mesh_terms: D000818:Animals; D000906:Antibodies / Q000032:analysis; D002060:Bursa of Fabricius / Q000166:cytology*; D002645:Chickens; D004912:Erythrocytes / Q000276:immunology; D007114:Immunization; D008214:Lymphocytes / Q000166:cytology; D008938:Mitosis; D008940:Mitotic Index; D009929:Organ Size; D012756:Sheep / Q000097:blood; D013997:Time Factors
chemical_list: D000906:Antibodies