Monoamine oxidase and pyruvate oxidase inhibitory properties of some newer thiosemicarbazones and their anticonvulsant activity.
Seventeen 4-[3-(N-cyclohexylamino)propyl]-1-substituted-3-thiosemicarbazones were synthesized and evaluated for their ability to inhibit rat brain monoamine oxidase (MAO) and pyruvate oxidase in vitro. Anticonvulsant activity exhibited by these thiosemicarbazones (100 mg/kg,i.p.) against pentylenetetrazol-induced seizures ranged from 10-50%.
D000818:Animals; D000927:Anticonvulsants; D001921:Brain / Q000201:enzymology; D005260:Female; D008297:Male; D051379:Mice; D008996:Monoamine Oxidase Inhibitors; D011771:Pyruvate Oxidase / Q000037:antagonists & inhibitors*; D051381:Rats; D013882:Thiosemicarbazones / Q000494:pharmacology*
D000927:Anticonvulsants; D008996:Monoamine Oxidase Inhibitors; D013882:Thiosemicarbazones; D011771:Pyruvate Oxidase