title: Deep controlled hypotension with sodium nitroprusside in the surgical treatment of intracranial arterial aneurysms.
abstract: The authors report 73 cases of intracranial arterial aneurysms operated on under deep controlled hypotension--i.e. hypotension below 60 mmHg of systolic arterial pressure (s.a.p.)--. Deep hypotension was induced by Sodium Nitroprusside (SNP). No problems were encountered in order to reach or to maintain deep hypotension. SNP showed to be an easy hypotensive agent, without toxicity at the recommended dosage. Fifty-nine patients were operated on between 40 and 25 mmHg of s.a.p. In 55 patients deep hypotension lasted for 30 minutes or more, reaching 2 hours in 3 patients. Surgical results were excellent, in regard either to the control of bleeding, either to the dissection of the aneurysm. Clinical results were evaluated by comparison with 146 patients operated on under normal pressure (group of control); no complications were clearly related to deep hypotension per se. However, the authors stress the risks of deep hypotension in early surgery, due to the possible association to vascular spasm.
mesh_terms: D001794:Blood Pressure / Q000187:drug effects; D002543:Cerebral Hemorrhage / Q000601:surgery; D002560:Cerebrovascular Circulation / Q000187:drug effects; D005292:Ferricyanides / Q000627:therapeutic use*; D006801:Humans; D007023:Hypotension, Controlled; D002532:Intracranial Aneurysm / Q000601:surgery*; D002546:Ischemic Attack, Transient / Q000401:mortality; D009599:Nitroprusside / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000401:mortality; D012422:Rupture, Spontaneous
chemical_list: D005292:Ferricyanides; D009599:Nitroprusside