Pharmacological study of bovine airways. Evidence for excitatory and inhibitory effects of histamine.
Bovine airway muscle contracts to carbachol greater than histamine greater than 2-methylhistamine greater than prostaglandin F2 alpha. Trachea of neonatal calves are more sensitive to histamine than those of older cattle. Partially contracted bovine airways relax to prostaglandins E1 and E2 greater than dopamine greater than phenylephrine greater than 4-methylhistamine greater than dimaprit. Histamine-induced airway constriction was incompletely blocked by mepyramine and the mepyramine-resistant component was blocked by atropine. After H1-receptor blockade, histamine-induced tracheobronchial relaxation was incompletely antagonized by metiamide and not blocked by propranolol or indomethacine, suggesting an atypical histamine receptor not associated with catecholamine or prostaglandin production.
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001285:Atropine / Q000494:pharmacology; D001920:Bradykinin / Q000494:pharmacology; D001980:Bronchi / Q000187:drug effects*; D002217:Carbachol / Q000494:pharmacology; D002417:Cattle / Q000502:physiology*; D006632:Histamine / Q000494:pharmacology*; D008785:Metiamide / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011460:Prostaglandins F / Q000494:pharmacology; D011738:Pyrilamine / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology; D014132:Trachea / Q000187:drug effects*
D011460:Prostaglandins F; D012701:Serotonin; D008785:Metiamide; D001285:Atropine; D006632:Histamine; D002217:Carbachol; D011433:Propranolol; D011738:Pyrilamine; D001920:Bradykinin