Fanconi's anaemia associated with haemophilia A.
Fanconi's anaemia and haemophilia A are born inherited diseases creating haemostatic defects. The association of these two rare diseases in one patient is described. The patient's haemophilia was studied with a newly developed immunological technique determining the plasma antigen associated with Factor VIII activity, and was found to be a genetic variant of moderately severe haemophilia A. It was not possible to demonstrate a common bone marrow defect or a common immunological or genetical background of the two diseases. The double haemostatic defect created, i.e. Factor VIII deficiency and thrombocytopenia, resulted in only a slight increase in bleeding tendency. A favourable result was obtained with corticosteroid and androgenic treatment.
D000015:Abnormalities, Multiple / Q000235:genetics; D000741:Anemia, Aplastic / Q000235:genetics*; D002648:Child; D005169:Factor VIII / Q000032:analysis; D005199:Fanconi Anemia / Q000097:blood / Q000150:complications / Q000235:genetics*; D006467:Hemophilia A / Q000150:complications / Q000235:genetics*; D006801:Humans; D008297:Male; D013921:Thrombocytopenia / Q000235:genetics
D005169:Factor VIII