title: The chemistry of diclofenac sodium (Voltarol).
abstract: The study of phenylbutazone and of the major anti-inflammatory agents which followed a decade later provided target criteria for a research project aimed at the synthesis of a new anti-inflammatory agent with superior activity and tolerability. Diclofenac fulfils the steric and physicochemical criteria, and the absence of a heterocyclic ring from its chemical structure may have a beneficial influence on its tolerability.
mesh_terms: D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis; D055598:Chemical Phenomena; D002621:Chemistry; D004008:Diclofenac; D010648:Phenylacetates
chemical_list: D000893:Anti-Inflammatory Agents; D010648:Phenylacetates; D004008:Diclofenac