Proliferative effect of lithocholic acid on rat liver cell in culture.
In contrast to cholic acid, deoxycholic acid and chenodeoxycholic acid, lithocholic acid (LCA) enhances the growth of rat liver cells in culture. Enhanced proliferation of LCA-treated rat liver cells persists even 12 days after LCA was removed. These findings could suggest a mutagenic effect of LCA, or a metabolite, on rat liver cells.
D000818:Animals; D001647:Bile Acids and Salts / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis; D008095:Lithocholic Acid / Q000494:pharmacology*; D008099:Liver / Q000166:cytology / Q000187:drug effects*; D051381:Rats
D001647:Bile Acids and Salts; D008095:Lithocholic Acid; D004247:DNA