Problems with activated charcoal and alumina as sorbents for medical use.
Although activated charcoal and alumina have been used extensively as sorbents in uremic patients, the following problems remain to be solved: 1) elution of SO4--from activated charcoal which does not adsorb it; 2) production of methylguanidine from creatinine on the surface of activated charcoal; 3) production of lipoperoxide from fatty acids by chemical reaction of activated charcoal; 4) adsorption of Ca++ and Mg++ when alumina adsorbs inorganic phosphate. These problems are studied in vitro and clinically.
D000327:Adsorption; D000535:Aluminum; D000537:Aluminum Oxide; D001806:Blood Urea Nitrogen; D002118:Calcium; D002606:Charcoal; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003404:Creatinine; D006801:Humans; D008054:Lipid Peroxides; D008760:Methylguanidine; D006435:Renal Dialysis; D013431:Sulfates; D014508:Urea
D008054:Lipid Peroxides; D013431:Sulfates; D002606:Charcoal; D008760:Methylguanidine; D014508:Urea; D003404:Creatinine; D000535:Aluminum; D000537:Aluminum Oxide; D002118:Calcium