title: Alterations of lactate dehydrogenase isoenzymes with subacute adriamycin toxicity.
abstract: Single doses of Adriamycin (ADR) and isoproterenol in CDF rats produce significant increases in total serum lactate dehydrogenase (LDH) activity, LDH isoenzymes, and LDH-1/LDH-2 ratio. Isoproterenol produced significant increases in LDH-1, LDH-2, and LDH-3 and the LDH-1/LDH-2 ratio; ADR produced significant increases in all isoenzymes, reflecting widespread toxicity, with peak levels of total LDH, LDH isoenzymes, and LDH-1/LDH-2 ratio at 48 hours after injection. While the increased LDH-1/LDH-2 ratio may suggest myocardial leakage with ADR administration, the results are too nonspecific to conclude that the heart is the primary source of serum LDH-1 and LDH-2.
mesh_terms: D000818:Animals; D009202:Cardiomyopathies / Q000139:chemically induced / Q000201:enzymology*; D004317:Doxorubicin / Q000633:toxicity*; D005260:Female; D007527:Isoenzymes; D007545:Isoproterenol / Q000633:toxicity; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D051381:Rats; D013997:Time Factors
chemical_list: D007527:Isoenzymes; D004317:Doxorubicin; D007770:L-Lactate Dehydrogenase; D007545:Isoproterenol