Electroencephalographic protective action of pyridoxylate during acute hypoxia and subsequent recovery in the rat.
Pyridoxylase at a concentration of 0.6 mmol/kg body weight injected intraperitoneally in rats, increased the resistance of animals to severe hypoxia (O2:3.2%; N2; 96.,%). The electrocorticogram (ECoG) was used to indicate the effectiveness of the drug in lowering the delay of electrographic silence, in 19 control rats and 12 pretreated rats. The ECoG was also recorded period under pure oxygen. In pretreated rats, the ECoG records became flat in a mean time of 551 s, compared with 269 s in the control group. The latent periods of successive steps during cerebral anoxia were significantly delayed in pyridoxylate-pretreated rats subjected to hypoxia. During the recovery period, pyridoxylate improved the recovery of the normal ECoG, particularly when values were expressed as a function of the duration of the hypoxic period. These findings are in good agreement with the significant protection afforded by pyridoxylate on the cerebral rate of energy-rich phosphate bond utilization during hypoxia studied in a separate work.
D000818:Animals; D001921:Brain / Q000503:physiopathology*; D004562:Electrocardiography; D006339:Heart Rate; D000860:Hypoxia / Q000517:prevention & control; D002534:Hypoxia, Brain / Q000503:physiopathology*; D007539:Isonicotinic Acids / Q000494:pharmacology*; D008297:Male; D011735:Pyridoxic Acid / Q000494:pharmacology*; D051381:Rats
D007539:Isonicotinic Acids; D011735:Pyridoxic Acid