title: [Epicritical evaluation of the submicroscopic aspects induced with administration of hepatotropic drugs].
abstract: Five currently drugs employed in the treatment of diseases of the liver were administered to groups of healthy rabbits to detect possible biochemical and ultrastructural changes induced in the liver cell. E.M. serography revealed various signs of morphological and metabolic disturbance, whose possible interpretation is discussed in the light of earlier investigations on a similar model relating to protective treatment of the membrane.
mesh_terms: D000620:Aminoimidazole Carboxamide / Q000494:pharmacology; D000818:Animals; D004338:Drug Combinations; D005978:Glutathione / Q000494:pharmacology; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D008854:Microscopy, Electron; D009963:Orotic Acid / Q000494:pharmacology; D011817:Rabbits; D012436:S-Adenosylmethionine / Q000494:pharmacology; D013876:Thiophenes / Q000494:pharmacology; D008625:Tiopronin / Q000494:pharmacology; D014532:Uridine Diphosphate Glucose / Q000494:pharmacology; D014805:Vitamin B 12 / Q000494:pharmacology
chemical_list: D004338:Drug Combinations; D013876:Thiophenes; D000620:Aminoimidazole Carboxamide; D009963:Orotic Acid; C025656:3-acetamido-2-hydroxytetrahydrothiophene; D012436:S-Adenosylmethionine; D008625:Tiopronin; D005978:Glutathione; D014805:Vitamin B 12; D014532:Uridine Diphosphate Glucose
vernacular_title: Valutazione epicritica degli aspetti submicroscopici indotti dalla somministrazione di farmaci ad azione epatotropa.