Effect of methylamalonic acid on gluconeogenesis in isolated rat and guinea-pig hepatocytes.
Gluconeogenesis from pyruvate, alanine, lactate and propionate was inhibited by methylmalonate in both rat and guinea-pig hepatocytes. The effect was dose-dependent. Gluconeogenesis from glycerol and xylitol was not affected.
D000818:Animals; D003864:Depression, Chemical; D005943:Gluconeogenesis / Q000187:drug effects*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008099:Liver / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008314:Malonates / Q000494:pharmacology*; D008764:Methylmalonic Acid / Q000494:pharmacology*; D051381:Rats
D008314:Malonates; D008764:Methylmalonic Acid