Stimulating effect of angiotensin II on the spontaneous release of newly synthetized [3H]dopamine in rat striatal slices.
Angiotensin II (A II) (10(-6) M, 10(-5) M, 5 . 10(-5) M) stimulated the spontaneous release of [3H]dopamine (DA) continuously synthetized from [3H]tyrosine in striatal slices of the rat. The A II-evoked release of [3H]-DA was prevented when slices were superfused with a calcium-free medium containing EGTA 5 . 10(-4) M. It was also suppressed in the presence of the potent antagonist Sar1-Ile8-angiotensin.
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D003342:Corpus Striatum / Q000032:analysis / Q000187:drug effects* / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D007031:Hypothalamus / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D011945:Receptors, Angiotensin / Q000032:analysis / Q000187:drug effects; D013268:Stimulation, Chemical
D011945:Receptors, Angiotensin; D000804:Angiotensin II; D004298:Dopamine; D009638:Norepinephrine