Alteration of brain noradrenaline, dopamine and 5-hydroxytryptamine levels during vanadium poisoning.
Effects of subacute and chronic intoxication with vanadium on the levels of noradrenaline (NA), dopamine (DA) and 5-hydroxytryptamine (5-HT) were examined. It was shown that subacute as well as chronic intoxication caused changes in levels of biogenic amines in the rat brain. NA concentration decreased whereas DA and 5-HT levels significantly increased. Vanadium in concentrations of 10(-3) and 10(-4) M inhibited the uptake of 3H-NA by cerebral cortex slices in vitro.
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D004298:Dopamine / Q000378:metabolism*; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D013997:Time Factors; D014639:Vanadium / Q000506:poisoning*
D014639:Vanadium; D012701:Serotonin; D004298:Dopamine; D009638:Norepinephrine