Structure of nanaomycin E, a new nanaomycin.
A new component, nanaomycin E, has been isolated from the culture broth of Streptomyces rosa var, notoensis, which had been found to produce nanaomycins A, B, C and D. Nanaomycin E was an epoxy derivative of nanaomycin A and was converted into nanaomycin A and 4a-epi-nanaomycin B by treatment with sodium hydrosulfite in an acidic aqueous solution. 4a-epi-Nanaomycin B was quantiatively converted into nanaomycin A under alkaline conditions.
D000900:Anti-Bacterial Agents / Q000302:isolation & purification; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D003470:Culture Media / Q000032:analysis; D004352:Drug Resistance, Microbial; D011809:Quinones / Q000032:analysis / Q000302:isolation & purification; D013302:Streptomyces / Q000378:metabolism; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D003470:Culture Media; D011809:Quinones