Open evaluation of labetalol in the treatment of angina pectoris occurring in hypertensive patients.
1 In nine hypertensive subjects with angina pectoris, labetalol diminished the incidence of chest pain occurring spontaneously or induced by exercise. 2 Labetalol lowered BP in all subjects. 3 Exercise tolerance at maximum levels was increased by labetalol. 4 Improved cardiac function by labetalol may be related to decreased afterload on the left ventricle, and diminished oxygen utilization by the myocardium.
D000787:Angina Pectoris / Q000150:complications / Q000188:drug therapy*; D001794:Blood Pressure / Q000187:drug effects; D004562:Electrocardiography; D004983:Ethanolamines / Q000627:therapeutic use*; D005132:Eye Manifestations; D005260:Female; D006339:Heart Rate; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*; D007741:Labetalol / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D005082:Physical Exertion
D004983:Ethanolamines; D007741:Labetalol