[Complement and nephritic activity in membranoproliferative glomerulonephritis].
A study of complement profiles and of "nephritic activity" (NeF activity) has been carried out in 33 children presenting with membranoproliferative glomerulonephritis (MPGN), in order to determine the pathway of complement activation. By morphological studies two varieties of MPGN have been distinguished. In MPGN with subendothelial deposits, immunofluorescent studies and complement profiles show an activation by the classical pathway. The demonstration of NeF activity in 7 of 20 patients suggests that there is recruitment of the amplification pathway. In MPGN with dense deposits, immunopathological studies indicate an activation of the complement system through the alternate pathway, NeF activity being present in 10 of 13 patients. With the functional tests used, it is not possible to ascertain that the factors responsible for the NeF activity in MPGN with subendothelial deposits are identical to the C3NeF identified in MPGN with dense deposits and/or partial lipodystrophy.
D002196:Capillaries / Q000473:pathology; D002648:Child; D003172:Complement C1 / Q000032:analysis; D003176:Complement C3 / Q000032:analysis; D003178:Complement C3 Nephritic Factor / Q000032:analysis*; D003181:Complement C4 / Q000032:analysis; D003182:Complement C5 / Q000032:analysis; D003169:Complement Inactivator Proteins / Q000032:analysis*; D003165:Complement System Proteins / Q000032:analysis*; D004727:Endothelium / Q000473:pathology; D005921:Glomerulonephritis / Q000276:immunology* / Q000473:pathology; D006801:Humans; D008566:Membranes / Q000473:pathology
D003172:Complement C1; D003176:Complement C3; D003178:Complement C3 Nephritic Factor; D003181:Complement C4; D003182:Complement C5; D003169:Complement Inactivator Proteins; D003165:Complement System Proteins
Complément et activité néphritique dans les glomérulonéphrites membranoprolifératives.