title: Histologic and electron-microscopic liver changes in diabetic children.
abstract: The results of 99 histologically examined liver biopsy samples--14 of them also examined under the electron microscope--taken from 68 insulin-treated diabetic children of both sexes at an age from 2-14 years. most of them with long-standing diabetes, are presented, thus giving a survey of morphologic liver findings of diabetes mellitus in this age group. Apart from metabolic changes, such as amount of fat and glycogen storage--including the nuclear glycogen of the liver--secondary diseases of inflammatory nature were found to play a prominent role in one third of the children. There are definite correlations with the degree of metabolic decompensation, demanding preventive and therapeutic measures.
mesh_terms: D000293:Adolescent; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D003920:Diabetes Mellitus / Q000473:pathology*; D003922:Diabetes Mellitus, Type 1 / Q000473:pathology*; D005234:Fatty Liver / Q000209:etiology; D005260:Female; D006505:Hepatitis / Q000209:etiology; D006529:Hepatomegaly / Q000209:etiology; D006801:Humans; D008099:Liver / Q000473:pathology*; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D008854:Microscopy, Electron
chemical_list: D008112:Liver Glycogen