Action of surface-active substances on biological membranes. IV. Hemolytic and membrane-perturbing action of homologous series of beta-D-glucopyranosyl-1-alkylphosphates.
The hemolytic action of a homologous series of beta-D-glucopyranosyl-1-alkylphosphates on human erythrocytes has been examined. The agent's affinity for the red cell membrane and the mean number of the agent's molecules which, upon interaction with an erythrocyte, make it undergo hemolysis have been measured. The contribution of the head group and that of a CH2 group of the surfactants to the free energy of the agents' binding to the cell membrane have been estimated. The effect of the surfactants on the red cell volume and the lytic concentrations of the agents have been measured. The contribution of a CH2 group to the free energy of the interaction of the amphiphiles embedded in the membrane bilayer with their environment has been evaluated and is proposed to be used as a measure of the membrane matrix stability.
D004910:Erythrocyte Membrane / Q000187:drug effects*; D004911:Erythrocyte Volume / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects*; D005958:Glucosephosphates / Q000494:pharmacology*; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D013501:Surface-Active Agents / Q000494:pharmacology*; D013816:Thermodynamics
D005958:Glucosephosphates; D013501:Surface-Active Agents