Hematological changes produced in mice by ochratoxin A.
The effects of ochratoxin A (5 mg/kg, intraperitoneal) on clotting time, hemoglobin, total count of red blood cells and white blood cells and differential count of white blood cells were studied in mice. This mycotoxin caused a significant decrease in the hemoglobin level and in the total count of red blood cells. Among white blood cells there was a significant increase in small lymphocytes and a significant fall in the count of neutrophils, basophils and monocytes in treated mice. The administration of ochratoxin A also prolonged the clotting time by more than 6-fold.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D004906:Erythrocyte Count; D006402:Hematologic Diseases / Q000139:chemically induced*; D006454:Hemoglobins / Q000378:metabolism; D007958:Leukocyte Count; D008297:Male; D051379:Mice; D009793:Ochratoxins / Q000633:toxicity*
D006454:Hemoglobins; D009793:Ochratoxins