Objective measurement of performance during acute stress in patients with essential hypertension: assessment of the effects of propranolol and metoprolol.
1. A standardized method of objectively measuring performance during simulated car driving is described. 2. The effect of a single dose of propranolol and metoprolol were compared with placebo in two groups of patients with untreated essential hypertension. 3. Performance was similar after beta-adrenoreceptor-blocking agents or placebo. 4. Blood pressure response to stress persisted after administration of the blocking agents.
D000328:Adult; D001334:Automobile Driving; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000503:physiopathology*; D008297:Male; D008790:Metoprolol; D011412:Propanolamines; D011433:Propranolol; D013315:Stress, Psychological / Q000150:complications / Q000503:physiopathology*
D011412:Propanolamines; D011433:Propranolol; D008790:Metoprolol