Liposome-incorporated corticosteroids. II. Therapeutic activity in experimental arthritis.
The anti-inflammatory activity of liposomes containing cortisol palmitate was determined in experimental acute arthritis in the rabbit knee by measuring joint temperature and diameter. The therapeutic activity of the liposome preparation was dose-dependent for both these parameters of inflammation. Liposomal corticosteroid therapy was effective also in decreasing the joint temperature of an acute inflammatory 'flare' superimposed on an underlying chronic arthritis. Phosphatidic acid was necessary for expression of full anti-inflammatory activity of the liposome preparation.
D000818:Animals; D001168:Arthritis / Q000188:drug therapy*; D001169:Arthritis, Experimental / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006614:Hindlimb; D006854:Hydrocortisone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D007249:Inflammation / Q000188:drug therapy; D007270:Injections, Intra-Articular; D007596:Joints; D008081:Liposomes / Q000008:administration & dosage*; D008297:Male; D010712:Phosphatidic Acids / Q000627:therapeutic use; D010713:Phosphatidylcholines / Q000627:therapeutic use; D011817:Rabbits
D008081:Liposomes; D010712:Phosphatidic Acids; D010713:Phosphatidylcholines; C016318:cortisol-21-palmitate; D006854:Hydrocortisone