[Effect of sodium hydroxybutyrate on cerebral circulation and regional vasomotor reflexes].
In experiments on cats it was found using electromagnetic and resistographic methods that sodium hydroxybutyrate (100 mg/kg) considerably increases cerebral circulation. The drug also potentiates the blood flow to the brain during formation of pressor reflexes of the arterial pressure. The blood flow increase is also observed in the system of femoral arteries while in the intestinal artery, on the contrary, there is a reduction in the blood flow increase during vasomotor reflexes. The reflex changes of the resistance in regional vessels are also different: the inhibition of pressor reflexes in the cerebral vessels along with their facilitation in the intestinal and femoral arteries and the potentiation of the reflex dilatatory phase in the limb vessels are seen. Different sensitivity to the drug of synaptic formations in the central links of various regional vasomotor reflexes is likely to underlie the difference described.
D000818:Animals; D001158:Arteries / Q000502:physiology; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D005260:Female; D006885:Hydroxybutyrates / Q000494:pharmacology*; D012018:Reflex / Q000187:drug effects*
D006885:Hydroxybutyrates
Bliianie natriia oksibutirata na mozgovoe krovoobrashchenie i regnonarnye sosudodvigatel'nye refleksy.