Abnormal whole-body and cellular (erythrocytes) turnover of 22Na+ in normotensive relatives of probands with established essential hypertension.
1. Whole-body elimination rate of 22Na+ was decreased in normotensive or borderline first-degree relatives of hypertensive probands. 2. Whole-body potassium, exchangeable sodium and urine excretion of sodium, potassium and creatinine were similar in relatives and controls. 3. Erythrocyte net influx of 22Na+ was significantly increased in normotensive relatives. 4. Abnormal whole-body and cellular handling of sodium (22Na+) demonstrated in relatives indicates that this abnormality may have an important role in the development of essential hypertension in man.
D004912:Erythrocytes / Q000378:metabolism*; D006207:Half-Life; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000235:genetics*; D007700:Kinetics; D011188:Potassium / Q000378:metabolism; D012964:Sodium / Q000097:blood*
D012964:Sodium; D011188:Potassium