Metabolism of N-acetyl PGE2 carboxamide in the rat.
After intratracheal administration to rats, the bronchodilator N-acetyl PGE2 carboxamide was converted rapidly to PGE2 and 13,14-dihydro-15-keto-PGE2, the major plasma metabolite. Oxidation of the N-acetyl carboxamide by prostaglandin dehydrogenase and hydrolysis of the imide bond were demonstrated in vitro.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D015232:Dinoprostone / Q000031:analogs & derivatives*; D006868:Hydrolysis; D006911:Hydroxyprostaglandin Dehydrogenases / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D010084:Oxidation-Reduction; D011459:Prostaglandins E, Synthetic / Q000378:metabolism*; D051381:Rats
D011459:Prostaglandins E, Synthetic; C024543:N-acetylprostaglandin E2 carboxamide; D006911:Hydroxyprostaglandin Dehydrogenases; D015232:Dinoprostone