Cytocidal effect of rifamycin derivatives on ascites tumor cells: studies with [125I]iododeoxyuridine.
The cytotoxicity of 2 rifamycin derivatives, rifazone-82 and rifampicin, on mouse ascites cells was studied, using the [125I]iododeoxyuridine (IUDR) method of labeling the tumor cells. This technique allows a distinction to be made between a cytocidal and cytostatic effect. The 2 drugs exerted a cytocidal effect against 2 non-leukemic cell lines, but had no effect against 3 leukemic lines.
D000230:Adenocarcinoma / Q000188:drug therapy; D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D005260:Female; D007065:Idoxuridine / Q000378:metabolism; D007457:Iodine Radioisotopes; D007942:Leukemia, Experimental / Q000188:drug therapy; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D012293:Rifampin / Q000627:therapeutic use; D012294:Rifamycins / Q000627:therapeutic use*; D014184:Transplantation, Homologous
D007457:Iodine Radioisotopes; D012294:Rifamycins; C016718:rifazone-82; D007065:Idoxuridine; D012293:Rifampin