[Embryotropic action of phenazepam in mini pigs, a new species of experimental animals].
It has been established in experiments on mini pigs of Siberian origin that phenazepam given at a dose of 1 mg/kg per os during organogenesis has no embryotoxic or teratogenic action. The drug content in the blood of pregnant animals was determined simultaneously. A conclusion is drawn about perspectiveness of using mini pigs for testing embryotoxic activity of drugs.
D000818:Animals; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000097:blood / Q000494:pharmacology*; D004195:Disease Models, Animal; D004622:Embryo, Mammalian / Q000187:drug effects*; D005260:Female; D011247:Pregnancy; D011270:Pregnancy, Animal; D013552:Swine; D013723:Teratogens
D001570:Benzodiazepinones; D013723:Teratogens; D001569:Benzodiazepines; C017928:phenazepam
Izuchenie embriotropnogo deĭstviia fenazepama v opytakh na minisvin'iakh - novom vide eksperimental'nykh zhivotnykh.