Metabolism of toluene in man: gas-chromatographic determination of o-, m- and p-cresol in urine.
Complete separation of phenol, o-, m- and p-cresol was achieved by capillary gas-chromatography. Urinary concentrations of cresols were determined quantitatively in samples from 10 male workers exposed to toluene. Besides p-cresol, o- and m-cresol were found to be urinary compounds in the case of the exposed group in contrast to normal persons. This finding was proved by gas-chromatography/mass spectrometry. The difference between both groups is significant. It is concluded that beside hippuric acid o-, m- and p-cresol are metabolites of toluene.
D001711:Biotransformation; D002849:Chromatography, Gas; D003408:Cresols / Q000652:urine*; D006626:Hippurates / Q000652:urine; D006801:Humans; D013058:Mass Spectrometry; D014050:Toluene / Q000378:metabolism*
D003408:Cresols; D006626:Hippurates; D014050:Toluene