The anthelmintic effects of flubendazole on Brugia pahangi.
The anthelmintic effects of flubendazole (methyl [5-(4-fluorobenzoyl)-1-H-benzimidazol-2-yl] carbamate) (Janssen Pharmaceutica) were evaluated in jirds (Meriones unguiculatus) and cats (Felis cattus) infected with Brugia pahangi. Flubendazole was macrofilaricidal at 5 x 2.5 mg/kg and 1 x 25 mg/kg in jirds and 1 x 100 mg/kg in cats when administered by subcutaneous injection. It also killed developing larvae in jirds. It was not microfilaricidal.
D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000627:therapeutic use*; D002009:Brugia / Q000187:drug effects / Q000254:growth & development; D002415:Cats; D004334:Drug Administration Schedule; D005260:Female; D005368:Filariasis / Q000188:drug therapy* / Q000469:parasitology; D008297:Male; D008463:Mebendazole / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use*; D012377:Rodentia
D000871:Anthelmintics; D001562:Benzimidazoles; D008463:Mebendazole; C018945:flubendazole