Chlorine dioxide metabolism in rat.
Chlorine dioxide (ClO2) is under consideration as an alternative to chlorination as a disinfectant for public water supplies. A new assay was developed to qualitatively and quantitatively measure the metabolites of 36ClO2 in water and biological fluids. Studies in the rat indicated that the metabolites of ClO2 were Cl-, ClO-2, and ClO-b. At maximum absorption the percentage of ClO; formed in plasma from an initial oral dose of 10 mg/l 36ClO, was higher than from a 100 mg/l dose. The 36Cl concentration in washed packed cells indicated that 36Cl readily exchanges with chloride of saline.
D000818:Animals; D002704:Chlorates / Q000032:analysis; D002713:Chlorine / Q000097:blood / Q000378:metabolism* / Q000652:urine; D017606:Chlorine Compounds; D004202:Disinfectants; D008297:Male; D010087:Oxides / Q000097:blood / Q000378:metabolism* / Q000652:urine; D010100:Oxygen / Q000032:analysis; D051381:Rats; D014881:Water Supply
D002704:Chlorates; D017606:Chlorine Compounds; D004202:Disinfectants; D010087:Oxides; D002713:Chlorine; C025109:chlorine dioxide; D010100:Oxygen