Pharmacological analysis of the effects of metoclopramide on the transmurally stimulated guinea-pig ileum.
The effects of metoclopramide (Mcp), a benzamide derivative, have been quantitatively analyzed on the responses of the isolated guinea-pig ileum to transmural stimulation. Mcp (0.03 microgram ml-1 upwards) increased these responses but this effect which was calcium-dependent was not concentration-dependent (up to 30 micrograms ml-1). Mcp antagonized the inhibitor effects of noradrenaline, dopamine, procaïne, adenosine triphosphate, bufexamac and hydrocortisone on the ileal responses, but not those of tetrodotoxin and verapamil.
D000818:Animals; D002118:Calcium / Q000502:physiology; D004558:Electric Stimulation; D005260:Female; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D008297:Male; D008787:Metoclopramide / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*
D008787:Metoclopramide; D002118:Calcium