title: Effects of urea treatment in combination with curettage in extensive periophthalmic malignancies.
abstract: 46 patients with 47 cancers of the eyelids and the canthi, large or very large in their great majority, were treated with local urea injections in combination with thorough curettage. In 7 of the above patients, the caruncle and the conjunctiva were also affected. This treatment was effective in 100% of our cases. The full recovery of the skin which had been destroyed by the cancer, without any remnants of scar or other disfigurement, is a very remarkable phenomenon; the functional condition of the lids remained quite normal as well. So we can affirm that in extensive periophthalmic carcinomas, in which cure with conventional methods is very difficult or almost impossible, as in some reported cases, the afore-mentioned treatment gives the most beneficial results, without any of the disadvantages of these methods.
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000188:drug therapy*; D002281:Carcinoma, Basosquamous / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D003475:Curettage; D005142:Eyelid Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014508:Urea / Q000627:therapeutic use*
chemical_list: D014508:Urea