The SGOT/SGPT ratio--an indicator of alcoholic liver disease.
The SGOT/SGPT ratio is significantly elevated in patients with alcoholic hepatitis and cirrhosis (2.85 +/- 0.2) compared with patients with postnecrotic cirrhosis (1.74 +/- 0.2), chronic hepatitis (1.3 +/- 0.17), obstructive jaundice (0.81 +/- 0.06) and viral hepatitis (0.74 +/- 0.07). An SGOT/SGPT ratio greater than 2 is highly suggestive of alcoholic hepatitis and cirrhosis. It occurs in 70% of these patients compared with 26% of patients with postnecrotic cirrhosis, 8% with chronic hepatitis, 4% with viral hepatitis and none with obstructive jaundice.
D000410:Alanine Transaminase / Q000097:blood*; D001219:Aspartate Aminotransferases / Q000097:blood*; D004796:Clinical Enzyme Tests; D003937:Diagnosis, Differential; D006505:Hepatitis / Q000201:enzymology; D006519:Hepatitis, Alcoholic / Q000175:diagnosis* / Q000201:enzymology; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000175:diagnosis* / Q000201:enzymology; D008107:Liver Diseases / Q000175:diagnosis
D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase