Resetting of osmoreceptor response as cause of hyponatraemia in acute idiopathic polyneuritis.
In a patient with hyponatraemia associated with acute idiopathic polyneuritis plasma concentrations of antidiuretic hormone increased when hypertonic saline was infused intravenously, and urine osmolality rose concomitantly. A water load was excreted normally, while the plasma remained extremely hypo-osmolal. It is concluded that osmoregulation was functioning normally but was set abnormally low, possibly owing to a disturbance of the peripheral volume receptors.
D000208:Acute Disease; D001127:Arginine Vasopressin / Q000097:blood; D006801:Humans; D007010:Hyponatremia / Q000097:blood / Q000209:etiology* / Q000652:urine; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D011115:Polyneuropathies / Q000150:complications* / Q000378:metabolism; D012462:Saline Solution, Hypertonic; D014882:Water-Electrolyte Balance
D012462:Saline Solution, Hypertonic; D001127:Arginine Vasopressin