Modification of radiation-induced spleen weight changes in mice by 2-mercaptopropionylglycine.
It was found that the MPG partially protects the spleen against weight loss due to radiation, and exaggerates the compensatory reaction in the tissue during recovery. It is also concluded that MPG protects the stem cells in the spleen, which helps to restore the peripheral blood by extramedullary erythropoiesis.
D000603:Amino Acids, Sulfur / Q000494:pharmacology*; D000818:Animals; D007700:Kinetics; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D013154:Spleen / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects*; D008625:Tiopronin / Q000494:pharmacology*
D000603:Amino Acids, Sulfur; D008625:Tiopronin