Treatment of renal amyloidosis with dimethylsulphoxide (DMSO).
Amyloid fibrils can be dissolved by dimethylsulphoxide (DMSO) in vitro and in vivo. This prompted us to investigate the therapeutic value of DMSO in renal failure caused by amyloidosis. Two patients with renal failure caused by secondary amyloidosis due to rheumatoid arthritis, showed a remarkable improvement of renal function. The effect of DMSO in amyloidosis secondary to rheumatoid arthritis seems to depend on its anti-inflammatory action, resulting in a decrease in amyloid formation. No evidence was found for an increase in amyloid degradation. The effect of DMSO in primary amyloidosis was inconclusive.
D000686:Amyloidosis / Q000150:complications / Q000188:drug therapy* / Q000209:etiology; D001172:Arthritis, Rheumatoid / Q000150:complications; D009202:Cardiomyopathies / Q000150:complications; D004121:Dimethyl Sulfoxide / Q000627:therapeutic use*; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D007677:Kidney Function Tests; D000685:Serum Amyloid A Protein
D000685:Serum Amyloid A Protein; D004121:Dimethyl Sulfoxide