Effects of some antiarrhythmic agents on dog heart mitochondrial oxidative phosphorylation.
Significant decreases in state 3 oxygen consumption, respiratory control index (RCI), ADP : O ratio and phosphorylation rate were observed in the presence of 0.1-1.0 mM quinidine; 0.5 mM or greater concentrations elevated state 4 oxygen consumption. Lidocaine (1-2.5 mM) also depressed RCI and increased state 4 oxygen consumption but procaine amide (1-2.5 mM) was without effect. It is suggested that cardiodepression by quinidine may be associated with its ability to impair mitochondrial metabolism.
D000244:Adenosine Diphosphate / Q000378:metabolism; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D004285:Dogs; D066298:In Vitro Techniques; D008012:Lidocaine / Q000494:pharmacology; D008929:Mitochondria, Heart / Q000187:drug effects / Q000378:metabolism*; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects; D011342:Procainamide / Q000494:pharmacology; D011802:Quinidine / Q000494:pharmacology
D000889:Anti-Arrhythmia Agents; D000244:Adenosine Diphosphate; D008012:Lidocaine; D011802:Quinidine; D011342:Procainamide