Role of various amino acids on the modulation of dopamine release from nigro-striatal dopaminergic neurones.
The effects of various transmitter amino-acids on the striatal release of 3H-dopamine (3H-DA) were investigated both in vivo in cat and in vitro in rat striatal slices. When applied to the substantia nigra of the anaesthetized cat by means of a push-pull cannula, GABA induced an increase followed by a transient decrease of 3H-DA release in the ipsilateral caudate nucleus; glycine reduced 3H-DA release under similar experimental conditions. When added to the superfusion medium of rat striatal slices, GABA, glutamate and glycine increased the release of the newly synthetized 3H-DA, suggesting that these amino-acids are also directly or indirectly involved in the presynaptic modulation of striatal DA release.
D000818:Animals; D002415:Cats; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D005971:Glutamates / Q000494:pharmacology*; D005998:Glycine / Q000494:pharmacology*; D066298:In Vitro Techniques; D051381:Rats; D013378:Substantia Nigra / Q000187:drug effects* / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D005971:Glutamates; D005680:gamma-Aminobutyric Acid; D005998:Glycine; D004298:Dopamine