title: IgA nephropathy (Clinical, pathological and immunological findings).
abstract: Seventy-five biopsy samples from patients with chronic renal disorders were examined by the usual techniques of light microscopy and immunofluorescence; in fifteen patients IgA nephropathy was found. These patients were young adults; the onset of the disease was characterized by macrohematuria, and recurrent episodes of hematuria were observed. Histological examination revealed proliferative endothelio-mesangial glomerulonephritis at various stages of development with focal or diffuse patterns; immunofluorescence revealed constant and intense positive reactions for IgA mainly in association with C3. It is assumed that there is a relationship connecting the more advanced histological changes, a more severe clinical course and the presence of IgM deposits.
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D005921:Glomerulonephritis / Q000209:etiology; D006417:Hematuria / Q000209:etiology; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications*; D007070:Immunoglobulin A; D007674:Kidney Diseases / Q000150:complications / Q000209:etiology; D008297:Male; D008875:Middle Aged
chemical_list: D007070:Immunoglobulin A