title: Nitrogen bridgehead compounds. Part 7: Synthesis of anti-atherosclerotic pyrido[1,2-a]pyrimidines.
abstract: The synthesis of 9-substituted-pyrido[1,2-a]pyrimidines are described. The new compounds exhibit antiatherosclerotic effects. The 3-ethoxycarbonyl-6-methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine-9-acetic acid (Chinoin-123) has the most favourable effects.
mesh_terms: D000818:Animals; D001011:Aorta / Q000378:metabolism; D001161:Arteriosclerosis / Q000188:drug therapy*; D055598:Chemical Phenomena; D002621:Chemistry; D002784:Cholesterol / Q000378:metabolism; D005260:Female; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008297:Male; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000627:therapeutic use; D011817:Rabbits; D014280:Triglycerides / Q000378:metabolism
chemical_list: D008055:Lipids; D011743:Pyrimidines; D014280:Triglycerides; D002784:Cholesterol