title: Radiation-induced dominant lethal mutations in oocytes of Musca domestica.
abstract: Dominant lethal mutations induced by gamma-radiation were measured in stage-7 and stage-14 oocytes of Musca domestica. At both stages the data are consistent with the multi-hit theory on radiation induction of dominant lethals. This conclusion is supported by fractionation experiments which indicate that both S7 and S14 oocytes are capable of repairing, in different periods of time, a similar amount of dominant lethal damage.
mesh_terms: D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005720:Gamma Rays; D005799:Genes, Dominant; D005804:Genes, Lethal; D006793:Houseflies / Q000235:genetics*; D009865:Oocytes / Q000528:radiation effects*; D010063:Ovum / Q000528:radiation effects*