[Effect of saralasin infusion on glomerular filtration rate and sodium excretion in hypertensive patients (author's transl)].
Saralasin (S) infusion, at a dose of 10 micrograms/kg/min IV, decreased Glomerular Filtration Rate (GFR) in 18 hypertensive patients. This effect was more pronounced in those patients with angiotensinogenic hypertension due to the somation of the effects of S upon renal vasculature and systemic arterial pressure. A decrease in urinary sodium excretion was also observed being more intense in those patients whose systemic pressure also decreased during S infusion. In group II (10 hypertensive patients) infusion of S in increasing doses (0.1, 0.5, 1.0, 5.0 and 10.0 micrograms/kg/min) a progressive decrease in GFR was observed only when the arterial pressure also decreased. However urinary sodium excretion decreased progressively as S doses increased. This effect was not related to S effect upon arterial pressure. This observation indicates that S, like angiotensin II, has a direct effect upon the renal tubules evoking an increase of sodium reabsorption.
D000804:Angiotensin II / Q000031:analogs & derivatives*; D001794:Blood Pressure / Q000187:drug effects; D003404:Creatinine / Q000378:metabolism; D005919:Glomerular Filtration Rate / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000503:physiopathology* / Q000652:urine; D007684:Kidney Tubules / Q000378:metabolism; D011188:Potassium / Q000378:metabolism; D012504:Saralasin / Q000008:administration & dosage / Q000494:pharmacology*; D012964:Sodium / Q000378:metabolism / Q000652:urine*
D000804:Angiotensin II; D012964:Sodium; D003404:Creatinine; D012504:Saralasin; D011188:Potassium
Efeito da infusão de saralasina sobre o ritmo de filtração glomerular e a excreção urinária de sódio de pacientes hipertensos.