title: Fine structural correlations between the muscle pathology of amyotrophic lateral sclerosis (ALS) patients and experimental Ca-Mg deficient rats.
abstract: Nonspecific myofibrillar changes such as streaming of the Z-line, formation of rod-like structures, satellitosis, proliferation of sarcolemmal nuclei and papillary projection of the sarcolemma were recognized as a disorganization of the muscle itself. In addition, fine structural pathology in ALS specimens showed characteristically a pig-tail formation - 'Zopfformation' - which has been considered to have a neurogenic origin.
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000473:pathology*; D000818:Animals; D002118:Calcium / Q000172:deficiency*; D002467:Cell Nucleus / Q000648:ultrastructure; D004195:Disease Models, Animal; D006801:Humans; D008275:Magnesium Deficiency; D009132:Muscles / Q000473:pathology* / Q000648:ultrastructure; D051381:Rats; D012508:Sarcolemma / Q000648:ultrastructure
chemical_list: D002118:Calcium