title: Bayesian analysis of a dose-response experiment with serial sacrifices.
abstract: This paper presents analysis and comments which are believed to be appropriate for certain carcinogenesis studies where sacrifices are performed throughout the experiment. Estimates of the risk probability for each dose level and sacrifice time are found utilizing the sample likelihood as the posterior density. The dose-response relationship is investigated with these estimates as the response. In order to test if the dose is effective and to check the appropriateness of the time-to-incidence model a Bayesian multiple comparisons technique is introduced.
mesh_terms: D000818:Animals; D001499:Bayes Theorem; D002273:Carcinogens / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D008954:Models, Biological; D012306:Risk; D013997:Time Factors
chemical_list: D002273:Carcinogens