title: Methionine fortification of a soy protein formula fed to infants.
abstract: Data from study of nine normal full-term infants fed a soy isolate-based formula unsupplemented with methionine were compared with similar data from study of 10 similar infants fed the same formula supplemented with L-methionine and with data from previous studies of larger groups of infants receiving various other feedings. Food intake, growth, and serum chemical values were studied from 8 through 111 days of age. In addition, nitrogen balance studies were carried out. Statistically significant differences were as follows: lesser weight gain per 100 kcal by infants fed the unsupplemented soy isolate-based formula than by infants fed milk-based or other soy isolate-based formulas; lesser serum concentrations of albumin at age 28 days by infants fed the unsupplemented soy isolate-based formula than by breast-fed infants; greater serum concentrations of urea nitrogen by infants receiving the unsupplemented soy isolate-based formula than by those receiving the same formula supplemented with L-methionine. A number of other differences was noted but were not statistically significant. The results suggest that normal infants fed a formula providing 2.25 /100 kcal of a soy protein isolate not fortified with methionine performed less well during the first 6 weeks of life than did breast-fed infants and infants fed milk-based formulas or other soy isolate-based formulas fortified with methionine. The limiting nutrient appears to have been methionine.
mesh_terms: D000375:Aging; D001798:Blood Proteins / Q000378:metabolism; D001827:Body Height / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D004032:Diet; D005527:Food, Fortified / Q000592:standards; D006801:Humans; D007223:Infant; D007225:Infant Food / Q000592:standards*; D007231:Infant, Newborn; D008297:Male; D008715:Methionine / Q000097:blood / Q000494:pharmacology*; D014674:Plant Proteins, Dietary; D013025:Glycine max
chemical_list: D001798:Blood Proteins; D014674:Plant Proteins, Dietary; D008715:Methionine