Evidence for withdrawal from caffeine by rats.
Injections of caffeine produced avoidance of a novel flavor. Rats which had previously received injections of caffeine on each of twelve days avoided a novel solution which had been associated with the absence of caffeine. This and other controls suggest that physiological withdrqwal from caffeine is the mechanism for this avoidance.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D002110:Caffeine / Q000494:pharmacology; D006801:Humans; D008297:Male; D051381:Rats; D012439:Saccharin / Q000494:pharmacology; D013375:Substance Withdrawal Syndrome / Q000209:etiology* / Q000503:physiopathology
D002110:Caffeine; D012439:Saccharin