title: Family history in classical juvenile onset diabetes in relation to severity of the disease.
abstract: A group of 100 patients with juvenile diabetes, age at onset 1-15 years (7.1 +/- 3.9), was studied with reference to family history of diabetes (FHD), HLA-types, symptoms at onset of diabetes, and occurrence of partial postinitial remission. No significant relations were seen between HLA-types and FHD. Nor was there any correlation between FHD and age at onset of diabetes, severity of th disease at onset, or occurrence of remission. Patients with a dominant type of inheritance were insulin-dependent to the same extent as those with less pronounced or no known FHD. According to previous results, it is concluded that all children and adolescents with a newly diagnosed diabetes should receive insulin treatment immediately to minimize further loss of B-cell function.
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics* / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D010375:Pedigree