title: Hyperalgesia induced by naloxone follows diurnal rhythm in responsivity to painful stimuli.
abstract: A diurnal rhythm was observed in the responsiveness of mice to nociceptive stimuli and in the hyperalgesic activity of endogenous opioid peptides and may partly account for previous controversy over the direct action of naloxone in opiate-naive animals.
mesh_terms: D000818:Animals; D002940:Circadian Rhythm; D004723:Endorphins / Q000502:physiology; D004745:Enkephalins / Q000502:physiology; D006358:Hot Temperature; D006930:Hyperalgesia / Q000139:chemically induced* / Q000503:physiopathology; D006941:Hyperesthesia / Q000139:chemically induced*; D051379:Mice; D009270:Naloxone / Q000009:adverse effects / Q000494:pharmacology*; D011930:Reaction Time / Q000187:drug effects
chemical_list: D004723:Endorphins; D004745:Enkephalins; D009270:Naloxone