Effect of anticonvulsants on plasma testosterone and sex hormone binding globulin levels.
Plasma sex hormone binding globulin (SHBG) and testosterone levels were measured in 29 patients with epilepsy (16 men and 13 women), most of them on chronic therapy with anticonvulsant drugs. Sex hormone binding globulin concentrations were increased in both sexes and testosterone levels in male patients. It is postulated that anticonvulsants may induce hepatic synthesis of SHBG.
D000927:Anticonvulsants / Q000494:pharmacology* / Q000627:therapeutic use; D002220:Carbamazepine / Q000494:pharmacology; D004833:Epilepsy, Temporal Lobe / Q000097:blood / Q000188:drug therapy; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010634:Phenobarbital / Q000494:pharmacology; D010672:Phenytoin / Q000494:pharmacology; D012737:Sex Factors; D012738:Sex Hormone-Binding Globulin / Q000032:analysis* / Q000378:metabolism; D013739:Testosterone / Q000097:blood*
D000927:Anticonvulsants; D012738:Sex Hormone-Binding Globulin; D002220:Carbamazepine; D013739:Testosterone; D010672:Phenytoin; D010634:Phenobarbital