Tryptophan metabolism in animals with dermatitis. II) In guinea pigs.
Tryptophan load in guinea pigs after induction of a photodermatitis from psoralen caused marked increase of urinary excretion of total metabolites "via kynurenine" in comparison with that obtained before dermatitis. Xanthurenic acid is the metabolite which showed the most increased levels in urine during dermatitis. This dermatitis from furocoumarin caused an alteration of tryptophan metabolism in guinea pigs as well as rats, but species differences in the excretion of metabolites after amino acid load are observed.
D000818:Animals; D003877:Dermatitis, Contact / Q000209:etiology / Q000378:metabolism*; D005363:Ficusin; D006168:Guinea Pigs; D007737:Kynurenine / Q000652:urine; D010787:Photosensitivity Disorders / Q000378:metabolism*; D014364:Tryptophan / Q000378:metabolism*; D014977:Xanthurenates / Q000652:urine
D014977:Xanthurenates; D007737:Kynurenine; D014364:Tryptophan; D005363:Ficusin