title: Synthesis and antitumour activity of new daunorubicin and adriamycin analogues.
abstract: A new synthetic procedure for the preparation of daunorubicin and adriamycin analogues bearing different substituents on ring D, has been developed. The new compounds display outstanding efficacy against experimental tumours of mice.
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D003630:Daunorubicin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000627:therapeutic use; D004317:Doxorubicin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000627:therapeutic use; D006367:HeLa Cells / Q000187:drug effects; D007942:Leukemia, Experimental / Q000188:drug therapy*; D013329:Structure-Activity Relationship
chemical_list: D004317:Doxorubicin; D003630:Daunorubicin