[Effect of lithium chloride on several indices of cardiac function].
Used in a dose of 100 mg/kg lithium chloride modifies the ECG patterns in rats, rabbits and cats. It increases the voltage of P and R waves, the S-T interval and slows down the rhythm of cardiac contractions. In doses of 50-300 mg/kg the compound raises the coronary circulation rate in narcotized cats. The compound exerts an antiarrhythmic action in chlorocalcium arrhythmia in rats, in strophanthin-induced one in cats and frogs and the intensity of this action is not inferior to that produced by potassium chloride, quinidine, novacainamide, izoptin and even exceeds it.
D000818:Animals; D000889:Anti-Arrhythmia Agents; D001001:Anura; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000517:prevention & control; D002122:Calcium Chloride; D002415:Cats; D003326:Coronary Circulation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000187:drug effects*; D008094:Lithium / Q000494:pharmacology* / Q000627:therapeutic use; D010946:Plants, Medicinal; D011189:Potassium Chloride / Q000627:therapeutic use; D011343:Procaine; D011802:Quinidine / Q000627:therapeutic use; D011817:Rabbits; D051381:Rats; D013328:Strophanthins; D014700:Verapamil / Q000627:therapeutic use
D000889:Anti-Arrhythmia Agents; D013328:Strophanthins; D011343:Procaine; D011189:Potassium Chloride; D008094:Lithium; D014700:Verapamil; D011802:Quinidine; D002122:Calcium Chloride
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