[Intramuscular injections and activity of serum creatine phosphokinase. Histopathological study in animal experiments].
In healthy Labrador dogs a single intramuscular injection of benzoctamin, diazepam and pethidin leads to a distinct increase in serum-creatine-phosphokinase (SCK) activity, whilst a single intramuscular injection of physiologic saline has no effect whatsoever. Intravenous injection of an identical dose of the above-mentioned drugs leaves SCK activity unchanged. Muscle specimens of the injection site, excised 5 days after intramuscular injection of the same drugs, display muscle cell necrosis, macrophage proliferation and reparative changes. The impressive histological alterations point to the striated muscle cell as a probable source of the increase in SCK activity (MM fraction).
D000818:Animals; D000873:Anthracenes / Q000008:administration & dosage / Q000494:pharmacology; D003402:Creatine Kinase / Q000097:blood*; D003975:Diazepam / Q000008:administration & dosage / Q000494:pharmacology; D004285:Dogs; D006801:Humans; D007273:Injections, Intramuscular; D008614:Meperidine / Q000008:administration & dosage / Q000494:pharmacology; D009132:Muscles / Q000166:cytology; D009206:Myocardium / Q000166:cytology
D000873:Anthracenes; D008614:Meperidine; D003402:Creatine Kinase; D003975:Diazepam
Intramuskuläre Injektionen und Serumkreatinphosphokinase-Aktivität Ein tierexperimenteller histopathologischer Beitrag.