Destruction of the platelet aggregating activity of ristocetin A.
Hydrolysis of ristocetin A in 0.1 N HCl at 37 degrees C for 2 h resulted in the loss of its ability to induce platelet aggregation in platelet-rich plasma derived from guinea-pigs and humans. However its antibiotic activity against Staph. aureus was not lost.
D000818:Animals; D006168:Guinea Pigs; D006801:Humans; D006868:Hydrolysis; D010974:Platelet Aggregation / Q000187:drug effects*; D012310:Ristocetin / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects
D012310:Ristocetin; C016719:ristocetin A