title: Hormonal control of sexual attraction in pseudohermaphroditic female dogs.
abstract: Groups of female dogs exposed to different degrees of androgenic stimulation during development and a control group of ovariectomized females were tested for their attraction to tethered male and female stimulus animals. Attraction to the male was measured before and after administration of estradiol, and attraction to an estrous female was tested before and after administration of testosterone propionate (TP). Time spent visiting the tethered male was approximately equal for all groups prior to hormone treatment, but after receiving estradiol, control females exhibited a pronounced increase in visiting time; the second longest visits were paid by females that had received moderate amounts of androgen before birth; more heavily androgenized females exhibited no increase in attraction to the male despite estradiol injections. Visits to the estrous female before administration of TP were longer for some groups than for others, but there was no relation between the degree of perinatal androgenization and mean visiting time. After injections to TP the most pronounced increase in visiting was shown by females that had received the largest amounts of androgen during development, and the second largest increase occurred in the prenatally androgenized group. Control females showed the smallest increase in visiting time.
mesh_terms: D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D002369:Castration; D012734:Disorders of Sex Development / Q000139:chemically induced; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000494:pharmacology*; D004971:Estrus; D005260:Female; D005333:Fetus / Q000187:drug effects; D011247:Pregnancy; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D013739:Testosterone / Q000494:pharmacology*
chemical_list: D013739:Testosterone; D004958:Estradiol