[Doses levorin display an antiandrogenic action?].
The antiandrogenic effect of levorin on immature castrated rats treated with exogenic testosterone was studied. In a dose of 200 mg/kg levorin lowered the cholesterin blood levels in the rats, inhibited the testosterone-induced increase in RNA concentration in the ventral and dorsal prostate and the seminal vesicles and to a less extent suppressed the growth of the accessory sexual glands. However, the antiandrogenic effect was observed with the use of levorin in the dose producing a pronounced toxic action evident from death of a part of the animals and a marked decrease in the animal body weight. This fact casts doubt on specificity of the levorin effect. Apparently, in high doses levorin impairs metabolism as a whole which cannot but affect the response of the sexual glands to administration of testosterone.
D000726:Androgen Antagonists; D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D002174:Candicidin / Q000494:pharmacology*; D002369:Castration; D002784:Cholesterol / Q000097:blood; D004247:DNA / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011467:Prostate / Q000187:drug effects; D012313:RNA / Q000378:metabolism; D051381:Rats; D012669:Seminal Vesicles / Q000187:drug effects; D013739:Testosterone / Q000494:pharmacology; D013997:Time Factors
D000726:Androgen Antagonists; D000935:Antifungal Agents; D002174:Candicidin; D013739:Testosterone; D012313:RNA; D004247:DNA; D002784:Cholesterol
Okazyvaet li levorin antiandrogennoe deĭstvie?