[Analysis of normal and methylated urinary nucleobases: a new criterion for diagnosis and follow-up of malignancies (author's transl)].
The qualitative and quantitative analysis by high performance liquid chromatography of the normal and modified nucleobases excreted in urine represents a new and versatile tool. Its use for the diagnosis of malignancies, deliminating infectious diseases, and for the follow-up of the effects of a cytostatic therapy is shown. This method offers a chance to introduce the analysis of a series of fragments of primary gene products into the routine of clinical biochemistry.
D000225:Adenine / Q000652:urine; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000652:urine; D006147:Guanine / Q000031:analogs & derivatives / Q000652:urine; D006801:Humans; D007223:Infant; D009369:Neoplasms / Q000652:urine*; D011687:Purines / Q000652:urine*
D011687:Purines; D006147:Guanine; D003404:Creatinine; D000225:Adenine
Die Analyse von normalen und methylierten Nucleobasen im Urin als neues Kriterium für Diagnose und Verlauf von Malignomen.