title: Serum and salivary digoxin concentrations in children.
abstract: Serum and salivary digoxin concentrations were measured in 53 children and correlated with ECG variables and serum potassium, calcium and magnesium concentrations. In 73% of patients cardiac failure was controlled, while only 7,5% of patients had serum digoxin concentrations within the 'therapeutic range'. It is proposed that the adult therapeutic range of 1-2 ng/ml is not applicable to children, who can be controlled at lower concentrations and/or that a significant proportion of the children studied no longer required maintenance digoxin therapy.
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004077:Digoxin / Q000009:adverse effects / Q000032:analysis* / Q000097:blood / Q000627:therapeutic use; D004562:Electrocardiography; D006331:Heart Diseases / Q000188:drug therapy; D006801:Humans; D007223:Infant; D012463:Saliva / Q000032:analysis*
chemical_list: D004077:Digoxin