[Morphometric characteristics of neuron-glial relations in brain edema caused by stimulation of hypothalamic nuclei].
Morphologic characteristics and certain changes in cell composition of the cortex and the white substance of the brain have been studied at experimentally produced brain edema by stimulation of the lateral hypothalamic field, the indefinite zone, Forel's fields H1 and H2. It has been stated that diffuse edema of the white substance and perivascular edema dominate in histopathological changes. Morphometrical analysis of the structural changes had demonstrated a certain increase in the cortex thickness, decreased density in the arrangement of the neurons and increased volume of their nuclei at more moderate enlargement of their body volumes, as well as increased volume of the nuclei in the cortical glial cells and the white substance cells. In the cortex cells is observed, that is accompanied with increased glial index and average number of perineuronal gliocytes per one neuron. Simultaneously, in both hemispheres, the character in the arrangement of the perineuronal glia as regards the neuron changes. At the same time, in the white substance, the density of the glial arrangement sharply decreases. The changes have demonstrated that wider perivascular spaces predominate in small vessels. All the changes mentioned are more pronounced in the contralateral hemisphere.
D000818:Animals; D001929:Brain Edema / Q000473:pathology*; D002415:Cats; D002467:Cell Nucleus; D002540:Cerebral Cortex / Q000473:pathology*; D006801:Humans; D007031:Hypothalamus; D009457:Neuroglia; D009474:Neurons
Morfometricheskaia kharakteristika neĭrono-glial'nykh otnosheniĭ pri oteke mozga, vyzvannom razdrazheniem iader gipotalamusa.