title: Differences in the effects of manganese and magnesium on initiation and elongation in the RNA polymerase I reaction.
abstract: The effects of magnesium and manganese in the initiation and elongation steps of the RNA polymerase I reaction in RNA synthesis were studied. For RNA chain initiation manganese was found to be a better effector than magnesium. For RNA chain elongation either manganese or magnesium acted as an effector, but a high concentration of manganese was inhibitory.
mesh_terms: D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000201:enzymology; D002466:Cell Nucleolus / Q000378:metabolism*; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism*; D008274:Magnesium / Q000494:pharmacology*; D008345:Manganese / Q000494:pharmacology*; D012318:RNA Polymerase I / Q000378:metabolism*; D014158:Transcription, Genetic / Q000187:drug effects*
chemical_list: D008345:Manganese; D012321:DNA-Directed RNA Polymerases; D012318:RNA Polymerase I; D008274:Magnesium