[Effect of rubomycin and carminomycin on antibody formation during the immunization of mice with various antigens].
The maximum immunodepressive effect of rubomycin and carminomycin was observed when the antibiotics were administered intravenously 24 hours after the immunization. The immune response induced by the sheep erythrocytes or the lipopolysaccharide was equally inhibited by rubomycin. Carminomycin in a dose of 0.5 mg/kg (0.1 of the LD50) to a larger extent inhibited the immune response stimulated by the lipopolysaccharide. Dependence of the immunodepressive effect of the antibiotics on their dose was found when the drugs were administered intravenously or orally.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000276:immunology*; D000917:Antibody Formation / Q000187:drug effects*; D000921:Antibody-Producing Cells / Q000187:drug effects; D000941:Antigens / Q000008:administration & dosage*; D002360:Carubicin / Q000276:immunology*; D003630:Daunorubicin / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D007114:Immunization; D007165:Immunosuppression Therapy; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA
D000903:Antibiotics, Antineoplastic; D000941:Antigens; D002360:Carubicin; D003630:Daunorubicin
Vliianie rubomitsina i karminomitsina na antiteloobrazovanie pri immunizatsii mysheĭ raznymi antigenami.