[Radioprotective effect of acute hypoxia on 5-day-old mice preliminarily adapted to oxygen deficiency].
Studies of 5-day mice F1 (CBA X C57Bl) demonstrated that an exposure of animals to acute hypoxia (5% O2--95% N2) during their irradiation produced a different effect on the spleen and the growing cerebellar cortex. In these circumstances lesions of well oxygenated spleen tissues were noticeably reduced, whereas cerebellar cortex cells characterized by a low oxygen tension and a high tolerance to anoxia remained essentially unprotected. The findings are discussed in the light of adaptation concepts postulating that oxygen tension in cells is regulated, depending on the level of its uptake which in turn is determined by the relative oxygen content in the surrounding medium.
D000208:Acute Disease; D000222:Adaptation, Physiological; D000818:Animals; D002525:Cerebellar Cortex / Q000528:radiation effects; D002588:Cesium Radioisotopes; D005720:Gamma Rays; D006824:Hybridization, Genetic; D000860:Hypoxia / Q000150:complications*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010100:Oxygen; D011833:Radiation Injuries, Experimental / Q000150:complications*; D013154:Spleen / Q000528:radiation effects
D002588:Cesium Radioisotopes; D010100:Oxygen
Osobennosti radiozashchitnogo éffekta ostroĭ gipoksii na 5-sutochnykh myshakh, predvaritel'no adaptirovannykh k usloviiam kislorodnoĭ nedostatochnosti.