[Transfusion of platelets loaded with periwinkle alkaloids as a treatment for chronic idiopathic thrombocytopenic purpura (author's transl)].
In a 70 year-old woman with a chronic idiopathic thrombocytopenic purpura refractory to all the therapeutic used, the absence of antiplatelet antibodies and the action of patient mononuclear cells on normal platelet 14C serotonin release was observed. The injection of vincristine loaded platelets was followed by a remission and a normalisation of the cellular immunological tests.
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000368:Aged; D001792:Blood Platelets / Q000276:immunology; D002908:Chronic Disease; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy; D014677:Pharmaceutical Vehicles / Q000627:therapeutic use*; D010983:Plateletpheresis; D011696:Purpura, Thrombocytopenic / Q000188:drug therapy* / Q000276:immunology; D014750:Vincristine / Q000276:immunology / Q000627:therapeutic use*
D000305:Adrenal Cortex Hormones; D014677:Pharmaceutical Vehicles; D014750:Vincristine
Traitement d'un purpura thrombopénique par la transfusion de plaquettes véhiculant de la vincristine (plaquettes "cheval de Troie").