[Fatal pancytopenia associated with sulfamethoxazole-trimethoprim therapy (author's transl)].
The authors report a case of fatal pancytopenia associated with sulfamethoxazole-trimethoprim therapy in a patient with folic acid deficiency. The mechanism is a matter of speculation, but the most attractive view is that the inhibiting effect of trimethoprim on dehydrofolate reductase can involve pancytopenia in patients with folic acid deficiency.
D004338:Drug Combinations; D005494:Folic Acid Deficiency / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D010198:Pancytopenia / Q000209:etiology*; D013420:Sulfamethoxazole / Q000009:adverse effects*; D014295:Trimethoprim / Q000009:adverse effects*
D004338:Drug Combinations; D014295:Trimethoprim; D013420:Sulfamethoxazole
Pancytopénie mortelle survenue au cours d'un traitement par sulfaméthoxazole-triméthoprime.