Effect of androstenedione on the oestrous cycle of the rat.
The implantation of Silastic capsules containing androstenedione (release rate 63.2 +/- 4.4 micrograms/24 h) into 4-day cyclic rats resulted in a prolongation of the cycle (P less than 0.001), most rats showing 5-day cycles after the first, largely unaffected cycle. There was a reduction in ovulation rate (P less than 0.01) and lower serum LH levels on the morning of oestrus (P less than 0.01) but serum FSH levels were unaffected.
D000735:Androstenedione / Q000494:pharmacology*; D000818:Animals; D004971:Estrus / Q000187:drug effects*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D009929:Organ Size / Q000187:drug effects; D010053:Ovary / Q000187:drug effects; D010060:Ovulation / Q000187:drug effects; D011247:Pregnancy; D051381:Rats
D000735:Androstenedione; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone