title: Effect of increased iodide intake on thyroid function in subjects on chronic lithium therapy.
abstract: Thyroid function tests were obtained in 10 patients on chronic lithium therapy before and after the administration of potassium iodide 250 mg q.i.d. Mean serum TSH rose by 8.9 muU/ml and mean serum T3 rose from 70 to 101 ng/dl. Two patients became hypothyroid; a third showed a rise in TSH without any change in T3 or T4. A fourth patient developed hyperthyroidism probably secondary to the Jod-Basedow phenomenon. Pharmacologic doses of iodine should be administered with caution to patients on chronic lithium therapy.
mesh_terms: D000328:Adult; D000368:Aged; D003863:Depression / Q000188:drug therapy; D005260:Female; D006801:Humans; D007454:Iodides / Q000009:adverse effects*; D008094:Lithium / Q000097:blood / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011193:Potassium Iodide / Q000009:adverse effects; D013961:Thyroid Gland / Q000187:drug effects* / Q000378:metabolism; D013972:Thyrotropin / Q000097:blood / Q000378:metabolism; D013974:Thyroxine / Q000097:blood / Q000378:metabolism; D014284:Triiodothyronine / Q000097:blood / Q000378:metabolism
chemical_list: D007454:Iodides; D014284:Triiodothyronine; D011193:Potassium Iodide; D013972:Thyrotropin; D008094:Lithium; D013974:Thyroxine