Effects of colchicine on the ovine corpus luteum: role of microtubules in the secretion of progesterone.
By 4 h after i.v. injection of ewes at the mid-luteal phase of the oestrous cycle with colchicine (1 mg/kg), the concentration of progesterone in peripheral plasma was halved while the content of progesterone in luteal tissue was doubled. The ultrastructure of the luteal tissue showed some specific drug-induced changes: microtubules were no longer present and the intracellular transport and secretion of granules associated with progesterone secretion appeared to be inhibited.
D000818:Animals; D003078:Colchicine / Q000494:pharmacology*; D003338:Corpus Luteum / Q000032:analysis / Q000187:drug effects* / Q000648:ultrastructure; D004971:Estrus; D005260:Female; D008870:Microtubules / Q000187:drug effects; D011247:Pregnancy; D011374:Progesterone / Q000032:analysis / Q000378:metabolism*; D012756:Sheep / Q000378:metabolism*
D011374:Progesterone; D003078:Colchicine