title: Plant anticancer agents III: Isolation of indole and bisindole alkaloids from Tabernaemontana holstii roots.
abstract: Certain active antileukemic and cytotoxic fractions prepared from Tabernaemontana holstii roots were investigated, resulting in the isolation of the known indole alkaloids conoduramine, conodurine, coronaridine, gabunine, 19-oxocoronaridine, pericyclivine, perivine, and vobasine. Two new alkaloids were assigned the structures 19-oxoconodurine and 19-(2-oxopropyl)conodurine. Both gabunine and 19-(2-oxopropyl)conodurine showed significant inhibitory activity against P-388 cell culture. All of the alkaloids are reported for the first time from T. holstii; conodurine, conoduramine, gabunine, perivine, and pericyclivine are reported for the first time from any Tabernaemontana species.
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000627:therapeutic use; D002478:Cells, Cultured; D002850:Chromatography, Gel; D066298:In Vitro Techniques; D007211:Indoles / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D007942:Leukemia, Experimental / Q000188:drug therapy; D009374:Neoplasms, Experimental / Q000188:drug therapy; D008517:Phytotherapy; D010946:Plants, Medicinal / Q000032:analysis*
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D007211:Indoles