Protein deprivation causes reversible impariment of mucosal immune response to cholera toxoid/toxin in rat gut.
Scretory antibodies may be the major defence against mucosal infections, especially those due to viruses and non-invasive pathogens such as Vibrio cholerae and toxinogenic Escherichia coli. The high incidence of mucosal infections in malnourished protein-deficient children may result from defective antibody production, but evidence for this is conflicting. We report here that protein deficiency markedly impairs the mucosal immune reponse to cholera toxiod/toxin (CT), a protein antigen, in rats and that this impairment is rapidly reversed by refeeding.
D000818:Animals; D000992:Antitoxins / Q000276:immunology; D002772:Cholera Toxin / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D004044:Dietary Proteins / Q000378:metabolism; D004195:Disease Models, Animal; D007071:Immunoglobulin A, Secretory / Q000378:metabolism; D007156:Immunologic Memory; D007413:Intestinal Mucosa / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology; D011488:Protein Deficiency / Q000276:immunology*; D051381:Rats; D013997:Time Factors
D000992:Antitoxins; D004044:Dietary Proteins; D007071:Immunoglobulin A, Secretory; D002772:Cholera Toxin