title: [Serial evaluation of blood polyamines in children treated with growth hormone].
abstract: Blood polyamines were evaluated in normal children of various ages (from infancy to adolescence). Polyamines show a distinctive pattern: maximal values were observed during infancy; they decrease during childhood and again increase at puberty. After i.m. injection of Human Growth Hormone (HGH), polyamine concentrations increase significantly in the first 60 minutes. Polyamines increase more in patients previously untreated or treated intermittently with HGH than in patients under continuous treatment. The results suggest that in humans as well as in animals, polyamines could be involved in the growth processes and that the effect of HGH probably consists in a stimulation of polyamine synthesis.
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D004393:Dwarfism, Pituitary / Q000097:blood* / Q000188:drug therapy; D013006:Growth Hormone / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D011073:Polyamines / Q000097:blood*
chemical_list: D011073:Polyamines; D013006:Growth Hormone
vernacular_title: Valutazione seriata delle poliamine ematiche in bambini trattati con l'ormone della crescita.