New esters of Halopredone for topical antiinflammatory use.
A series of new halopredone esters has been prepared and screened for local and systemic antiinflammatory activity. High local activity with no side effects, equivalent to that of 17,21-bis(acetyloxy)-2-bromo-6beta,9-difluoro-11beta-hydroxypregna-1,4-diene-3,20-dione (halopredone acetate; Topicon), is obtained when either the 17- or 21-OH of halopredone are benzoylated.
D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D001835:Body Weight / Q000187:drug effects; D004952:Esters; D006868:Hydrolysis; D009929:Organ Size / Q000187:drug effects; D011277:Pregnanediones / Q000008:administration & dosage* / Q000494:pharmacology; D051381:Rats
D000893:Anti-Inflammatory Agents; D004952:Esters; D011277:Pregnanediones