title: Serial bone scintigraphy for assessing the effectiveness of treatment of osseous metastases from prostatic cancer.
abstract: 130 serial bone scintigrams were performed to evaluate the course of skeletal metastases under treatment in 36 patients with prostatic cancer. During a successful treatment scintigraphic controls revealed a significant decrease of the metastatic 99mTc-diphosphonate uptake in 14 patients and sometimes even a complete normalization of the skeletal radioactivity distribution, whereas a progression characterized by an increased multifocal radioactivity concentration was registered in 16 patients indicating the failure of the initiated therapy. Based on these results of follow-up studies scintigraphic bone imaging can be recommended for the assessment of the effectiveness of on-going therapy of skeletal metastases.
mesh_terms: D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D004967:Estrogens / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis; D011471:Prostatic Neoplasms / Q000601:surgery / Q000628:therapy*; D011877:Radionuclide Imaging; D013737:Testis / Q000601:surgery
chemical_list: D004967:Estrogens