Time dependent changes in the pharmacokinetics of aspirin.
In an experiment carried out on six volunteers, measurement of total serum salicylate concentration was used to describe aspirin kinetics after a single 1500 mg oral dose. The availability of the drug was significantly better when it was administered at 6(00) than at 18(00) or 22(00). Also a significant time-dependence was found between the morning and evening values of both the serum half-life time of salicylate and kel. The possible relation between these results and the appearance of undesirable side effects in patients should be examined.
D000328:Adult; D001241:Aspirin / Q000378:metabolism*; D002940:Circadian Rhythm; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D012459:Salicylates / Q000097:blood; D013997:Time Factors
D012459:Salicylates; D001241:Aspirin