title: Mutagenicity of vinyl chloride. External chromosome studies on persons with and without VC illness, and on VC exposed animals.
abstract: Chromosome analysis was undertaken on lymphocyte cultures taken from (1) six workers with estimated exposure to VC and four workers with monitored exposure to VC (employed in the BASF); (2) 20 workers showing symptoms of VC illness with unknown exposure and one angiosarcoma case, due to VC exposure (not employed in the BASF); and, (3) on bone marrow cells of Chinese hamsters after inhalation of 2,500 ppm or 5,000 ppm, or after intraperitoneal injections of 300 mg/kg or 600 mg/kg. The proband groups showing symptoms of VC illness, the only living angiosarcoma case, and the animal test show a significant increase in the rate of aberrations in comparison to the control group.
mesh_terms: D000328:Adult; D000395:Air Pollutants, Occupational / Q000633:toxicity; D000818:Animals; D002869:Chromosome Aberrations; D006224:Cricetinae; D006390:Hemangioendothelioma / Q000139:chemically induced / Q000235:genetics; D006394:Hemangiosarcoma / Q000139:chemically induced / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009153:Mutagens / Q000633:toxicity*; D009784:Occupational Diseases / Q000139:chemically induced / Q000235:genetics*; D014752:Vinyl Chloride / Q000633:toxicity*; D014753:Vinyl Compounds / Q000633:toxicity*
chemical_list: D000395:Air Pollutants, Occupational; D009153:Mutagens; D014753:Vinyl Compounds; D014752:Vinyl Chloride