Levels of sulfhydryls and sulfhydryl-containing enzymes in brain, liver and testis of manganese treated rats.
The effect of manganese on sulfhydryls and sulfhydryl-containing enzymes in brain, liver and testis of rats was investigated. Manganese produced lowering in the contents of non-protein sulfhydryl groups and inhibited the activity of glucose-6-phosphate dehydrogenase and glutathione reductase in these tissues. The contents of the metal increased significantly in brain, liver and testis of manganese administered rats. The significance of these findings is discussed.
D000818:Animals; D001921:Brain / Q000201:enzymology / Q000378:metabolism*; D005954:Glucosephosphate Dehydrogenase / Q000037:antagonists & inhibitors; D005980:Glutathione Reductase / Q000378:metabolism; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D008345:Manganese / Q000494:pharmacology*; D011485:Protein Binding / Q000187:drug effects; D051381:Rats; D013438:Sulfhydryl Compounds / Q000378:metabolism*; D013737:Testis / Q000201:enzymology / Q000378:metabolism*
D013438:Sulfhydryl Compounds; D008345:Manganese; D005954:Glucosephosphate Dehydrogenase; D005980:Glutathione Reductase