Reversal of central anticholinergic syndrome by galanthamine.
Ten volunteers were given 2 mg scopolamine intravenously (IV) to produce substantial drowsiness and sleepiness. Galanthamine, 0.5 mg/kg IV, effectively reversed the central anticholinergic syndrome produced by scopolamine. Electroencephalographic monitoring of two subjects matched the observed changes of consciousness: scopolamine replaced the dominant awake alpha rhythm with a disorganized, slow, 4- to 6-Hz activity. Galanthamine promptly returned to EEG pattern to the control, awake state. Galanthamine produces effective, safe, and long-lasting reversal of the central anticholinergic syndrome in man.
D001812:Blood-Brain Barrier; D003693:Delirium / Q000139:chemically induced; D003702:Delusions / Q000139:chemically induced; D005702:Galantamine / Q000494:pharmacology*; D006212:Hallucinations / Q000139:chemically induced; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D012601:Scopolamine / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D012890:Sleep / Q000187:drug effects*; D013577:Syndrome; D014851:Wakefulness / Q000187:drug effects*
D005702:Galantamine; D012601:Scopolamine