[Relationship between the phase of the sex cycle and differences in the rate of hexenal detoxication and its induction by phenobarbital in female rats].
Differences in hexenal detoxication rate and its induction with small doses of phenobarbital in mongrel female rats, depending upon the stage of the sex cycle, were investigated. The application of the hexobarbital test demonstrated that the duration of a continuous lateral position and re-establishment of locomotion after administration of a standard dose of hexobarbital in the stages of proestrus and estrus are much shorter than they are in the stages meta- and diestrus. In females pretreated with small doses of phenobarbital were found the same temporal correlations of sleep and restored locomotion during corresponding cycles following administration of hexobarbital as in controls, but their levels proved 2-3 times lower respectively than they were in control females. Low doses of phenobarbital (10, 10 and 20 mg/kg) used in the present experiments are nearly as effective as are doses almost by one order higher (80-150 mg/kg), used by other authors.
D000818:Animals; D004971:Estrus; D005260:Female; D006591:Hexobarbital / Q000378:metabolism*; D008658:Inactivation, Metabolic; D007700:Kinetics; D010634:Phenobarbital / Q000494:pharmacology*; D011247:Pregnancy; D051381:Rats
D006591:Hexobarbital; D010634:Phenobarbital
Razlichiia skorosti detoksikatsii geksenala i induktsii ee fenobarbitalom u krys-samok v zavisimosti ot stadii polovogo tsikla.