The effect of basic proteins on the haemostatic system of the dog.
Intravenous administration of histones or protamine to dogs resulted in a fall of the number of blood platelets, a lowered prothrombin consumption, a fall in the fibrinogen level, activation of the fibrinolytic system and deterioration of blood clot retraction.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D004285:Dogs; D005340:Fibrinogen; D005342:Fibrinolysis / Q000187:drug effects; D006487:Hemostasis / Q000187:drug effects*; D006657:Histones / Q000494:pharmacology*; D010960:Plasminogen Activators; D010974:Platelet Aggregation / Q000187:drug effects; D010976:Platelet Count; D011479:Protamines / Q000494:pharmacology*; D011516:Prothrombin
D006657:Histones; D011479:Protamines; D011516:Prothrombin; D005340:Fibrinogen; D010960:Plasminogen Activators