Ketamine-induced rotation: interaction with GABA-transaminase inhibitors and picrotoxin.
Ketamine in a dose of 100 mg/kg (IP) produced stereotypic behavior and vigorous rotation in adult male Sprague-Dawley rats. The first rotation phase, accompanied by head swinging, was short and terminated by the anesthetic phase which lasted 20-30 min. The second rotation phase began 1-3 min after the end of the anesthetic phase. A single dose of GABA-T inhibitors, gamma-vinyl GABA (1200 mg/kg, IP) or gamma-acetylenic GABA (100 mg/kg, IP) administered 4 hours prior to ketamine, shortened the first rotation phase, increased the anesthetic phase, changed the pattern of postanesthetic rotation and reduced total and net rotation scores. Picrotoxin (3 mg/kg) given 10 min prior to ketamine tended to act in the opposite direction although none of its effects reached statistical significance.
D000612:4-Aminobutyrate Transaminase / Q000037:antagonists & inhibitors*; D000758:Anesthesia; D000818:Animals; D001519:Behavior / Q000187:drug effects*; D004347:Drug Interactions; D006801:Humans; D007649:Ketamine / Q000494:pharmacology*; D008297:Male; D010852:Picrotoxin / Q000494:pharmacology*; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects*; D000637:Transaminases / Q000037:antagonists & inhibitors*; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives / Q000494:pharmacology
D000612:4-Aminobutyrate Transaminase; D007649:Ketamine; D010852:Picrotoxin; D000637:Transaminases; D005680:gamma-Aminobutyric Acid