Observation of antibody activity against antibiotics in patients with atopic disease.
Antibodies to antibiotics were studied in patients hypersensitive to these preparations and in patients with other types of allergic disease. In addition to examining these antibodies, a whole series of other immunological tests were carried out (IgG, IgA, IgM, IgE, C'3 and OPI). Antibodies to antibiotics were found in a high percentage of subjects, not only in those hypersensitive to antibiotics but also in patients with asthma bronchiale and rhinitis pollinosa. The considerable differences in IgG and IgE observed in patients with high titres of haemagglutinating antibodies to antibiotics point out the blocking character of these antibodies.
D000700:Analgesics / Q000009:adverse effects; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D000906:Antibodies / Q000032:analysis*; D000983:Antipyrine / Q000009:adverse effects; D001249:Asthma / Q000276:immunology*; D004342:Drug Hypersensitivity / Q000209:etiology / Q000276:immunology*; D006386:Hemagglutination Tests; D007073:Immunoglobulin E / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology*
D000700:Analgesics; D000900:Anti-Bacterial Agents; D000906:Antibodies; D007074:Immunoglobulin G; D007073:Immunoglobulin E; D000983:Antipyrine