Non-specific reactions caused by diluents containing glycerol in nasal and bronchial challenge tests.
Sixty-one patients hospitalized because of asthma and/or allergic rhinitis were given nasal and bronchial challenge tests with diluents containing glycerol. 62% of the patients with rhinitis and 37% of those with asthma gave positive reactions. Glycerol should therefore not be used in allergen extracts which are meant for challenge tests. The non-specific effect of glycerol seems to be cumulative with increasing dose.
D000281:Administration, Intranasal; D000328:Adult; D001249:Asthma / Q000139:chemically induced*; D005541:Forced Expiratory Volume; D005990:Glycerol / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D012129:Respiratory Function Tests; D006255:Rhinitis, Allergic, Seasonal / Q000139:chemically induced*
D005990:Glycerol