[Effect of the diuretic Etozolin in patients with normal and impaired renal function (author's transl)].
The effect of the novel diuretic ethyl (Z)-(3-methyl-4-oxo-5-piperidino-thiazolidin-2-ylidene) acetate (etozolin, Gö 687, Elkapin) on renal function and especially on the elimination of solutes has been investigated under clearance conditions on 25 hydrated patients with different glomerular filtration rates (GFR). On normal persons the compound caused a decrease of GFR and of urea elimination while the absolute and the fractional elimination of sodium and chloride as well as the fractional potassium clearance increased significantly. In patients with chronic renal insufficiency (GFR less than 20 ml/min) these values could not be influenced. A significant correlation between initial GFR and decrease of GFR as well as between initial GFR and increase of renal elimination of sodium and chloride could be demonstrated: the lower the initial GFR the weaker the elimination of electrolytes and the decrease of the filtration rate, the latter being neglible at an initial GFR of 80 ml/min or less.
D000328:Adult; D002712:Chlorides / Q000652:urine; D004232:Diuretics / Q000494:pharmacology*; D005919:Glomerular Filtration Rate / Q000187:drug effects*; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D007674:Kidney Diseases / Q000503:physiopathology*; D008875:Middle Aged; D010880:Piperidines / Q000494:pharmacology; D011188:Potassium / Q000652:urine; D012964:Sodium / Q000652:urine; D013844:Thiazoles / Q000494:pharmacology*; D014882:Water-Electrolyte Balance / Q000187:drug effects
D002712:Chlorides; D004232:Diuretics; D010880:Piperidines; D013844:Thiazoles; D012964:Sodium; D011188:Potassium
Wirkung des Diuretikums Etozolin bei Patienten mit normaler und eingeschränkter Nierenfunktion.