Copper toxicity in sheep: the effects of  repeated intravenous injections of copper sulphate.
Four Clun Forest, Suffolk cross sheep were given daily intravenous injections of copper sulphate. Three similar sheep acted as controls. The copper dosed sheep developed haemolysis and showed liver, kidney and brain damage similar to that seen in chronic copper poisoning. All animals survived for 30 days and two would have lived longer. Reticulocytes were produced after four days and  continued to be produced, sometimes in high number throughout the course of the experiment.
D000818:Animals; D001663:Bilirubin / Q000097:blood; D003300:Copper / Q000008:administration & dosage / Q000097:blood / Q000633:toxicity*; D003967:Diarrhea / Q000662:veterinary; D007275:Injections, Intravenous; D007668:Kidney / Q000473:pathology; D008099:Liver / Q000473:pathology; D008297:Male; D012756:Sheep; D012757:Sheep Diseases / Q000097:blood / Q000139:chemically induced* / Q000473:pathology
D003300:Copper; D001663:Bilirubin