title: Immunoelectrophoretic studies on the kinetics of plasmic degradation of human fibrinogen.
abstract: In vitro degradation of fibrinogen results in the appearance of an early fragment, different in its electrophoretic mobility to that of fragments X, Y, D and E. It reacts with antifibrinogen antiserum does not react with anti-D antiserum and it is antigenically related to fragment E. Compared with terminal fragment E, it migrates more slowly towards the anode, it appears earlier and in a greater concentration at the beginning, decreasing and disappearing during degradation. The antigen antibody crossed electrophoresis was used in these experiments, but to distinguish the fragments from already known X, Y or even fibrinogen, the applying of an intermediate gel with anti D was of great value.
mesh_terms: D005338:Fibrin Fibrinogen Degradation Products; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D007122:Immunoelectrophoresis
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; D005340:Fibrinogen