[Effect of glucocorticoids on the level of transcortin-like cytoplasmic receptors].
Experiments were conducted on intact, adrenalectomized and stress-subjected male Wistar rats; the level of transcortin-like cytosol receptors of the lungs heart, kidneys, and the liver was studied by means of 3H-corticosterone and solid-phase sorption. The level of transcortin-like receptors in the cytosol of various tissues in intact rats had the following declining sequence; the lungs, heart, kidneys, liver. In stress the level of transcortin-like receptors in the tissue cytosol displayed a sharp reducion, although the sequence characteristic of intact animals persisted. In adrenalectomized rats stress induced no significant fall in the content of transcortin-like receptors in the tissue cytosol, whereas intraperitoneal administration of cortisol to adrenalectomized rats decreased the level of these receptors. A hypothesis was put forward on the antistress action of transcortin-like cytoplasm receptors.
D000818:Animals; D001665:Binding Sites; D003345:Corticosterone / Q000494:pharmacology*; D003600:Cytosol / Q000378:metabolism*; D006728:Hormones / Q000494:pharmacology; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology*; D007668:Kidney / Q000648:ultrastructure; D008099:Liver / Q000648:ultrastructure; D008168:Lung / Q000648:ultrastructure; D008297:Male; D009206:Myocardium / Q000648:ultrastructure; D051381:Rats; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000378:metabolism; D014156:Transcortin / Q000378:metabolism*
D006728:Hormones; D014156:Transcortin; D003345:Corticosterone; D006854:Hydrocortisone
Vliianie gliukokortikoidov na uroven' transkortinpodobnykh tsitoplazmennykh retseptorov.