Postsynaptic supersensitivity and kindling: further evidence of similarities.
Fourteen Sprague-Dawley rats of 150 to 200 g of initial weight were given either d-amphetamine or cocaine intermittently following both a drug-abuse model previously described by the author and an intermittent model for pharmacological "kindling." The psychotogenic effects of the drugs were measured as stereotyped behavior utilizing standardized scales. A retest with the same drug and same protocol as the pretest stage was executed after an off-drug period of 12 weeks, demonstrating dopamine receptors hypersensitivity as measured by stereotyped behavior for both d-amphetamine and cocaine. The importance of demonstrating dopamine receptor hypersensitivity with an intermittent (kindling) drug-abuse-type model is discussed.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001519:Behavior / Q000187:drug effects*; D003042:Cocaine / Q000008:administration & dosage / Q000494:pharmacology*; D003913:Dextroamphetamine / Q000008:administration & dosage / Q000494:pharmacology*; D004195:Disease Models, Animal; D006801:Humans; D007274:Injections, Intraperitoneal; D051381:Rats; D011954:Receptors, Dopamine; D013239:Stereotyped Behavior / Q000187:drug effects*; D013997:Time Factors
D011954:Receptors, Dopamine; D003042:Cocaine; D001058:Apomorphine; D003913:Dextroamphetamine