Effect of indoprofen on prostaglandin and thromboxane A2 synthesis in the guinea pig lung.
Indoprofen has been studied in vitro as a possible selective inhibitor of thromboxane-synthetase in guinea pig lungs perfused with arachidonic acid. Indoprofen does not show selectivity of action since KB values for prostaglandin and TXA2 synthesis are not significantly different. Indoprofen might therefore act at the cyclooxygenase level as has already been demonstrated for indomethacin.
D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism; D003864:Depression, Chemical; D005260:Female; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D007216:Indoprofen / Q000494:pharmacology*; D008168:Lung / Q000187:drug effects / Q000378:metabolism*; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010666:Phenylpropionates / Q000494:pharmacology*; D011453:Prostaglandins / Q000096:biosynthesis*; D013928:Thromboxane A2 / Q000096:biosynthesis*; D013931:Thromboxanes / Q000096:biosynthesis*
D001095:Arachidonic Acids; D010666:Phenylpropionates; D011453:Prostaglandins; D013931:Thromboxanes; D013928:Thromboxane A2; D007216:Indoprofen; D007213:Indomethacin