Halothane effects on conductivity of the AV node and His-Purkinje system in the dog.
His-bundle electrocardiography was used to evaluate the effect of halothane on AV nodal and His-Purkinje system conduction times in the spontaneously beating dog heart. During artrial pacing at basic heart rates of 120 or 200 beats per minute (bpm), an extrastimulus (cycle length longer or shorter than that of the basic rate) was delivered to test the effect of halothane on several parameters of AV nodal conductivity. Included were the functional refractory period, basal conduction time, and fatigue effect (prolongation of basal conduction time as heart rate was increased from 120 to 200 bpm). Increasing MAC level of halothane (1.25 to 2.75 MAC) prolonged both AV node and His-Purkinje conduction times, yet had little effect on the parameters of nodal conductivity tested for. These effects of halothane could be potentially dangerous in the clinical setting for patients with defective AV conduction. In addition, changes in conduction may be in part responsible for arrhythmias seen during halothane anesthesia.
D000758:Anesthesia; D000818:Animals; D001283:Atrioventricular Node / Q000187:drug effects / Q000502:physiology; D002036:Bundle of His / Q000187:drug effects / Q000502:physiology; D004285:Dogs; D004594:Electrophysiology; D006221:Halothane / Q000494:pharmacology*; D006329:Heart Conduction System / Q000187:drug effects* / Q000502:physiology; D011690:Purkinje Fibers / Q000187:drug effects / Q000502:physiology
D006221:Halothane