Action of bencyclane-hydrogen-fumarate on the carbohydrate metabolism of bovine lens homogenates.
1-Benzyl-1-(3-dimethylaminopropoxy)cycloheptane (bencyclane-hydrogen-fumarate; Fludilat) in a concentration of 10-2 M effects an increase in the O2 consumption and the formation of CO2 in a 10% bovine lens homogenate. This effect is even increased if the glucose-substrate supply is raised from 25 mM to 37 mM. Investigations on the concentrations at ATP, ADP and AMP show that bencyclane is able to stabilize the physiologic distribution pattern of the three free adenine nucleotides. Further, the observed changes in the distribution pattern indicated that the fumaric acid rest of bencyclane may serve as a substrate for this reaction in the same way as fumarate.
D000244:Adenosine Diphosphate / Q000378:metabolism; D000249:Adenosine Monophosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001537:Bencyclane / Q000494:pharmacology*; D050260:Carbohydrate Metabolism; D002245:Carbon Dioxide / Q000096:biosynthesis; D002417:Cattle; D003508:Cycloheptanes / Q000494:pharmacology*; D005650:Fumarates / Q000378:metabolism; D066298:In Vitro Techniques; D007908:Lens, Crystalline / Q000187:drug effects / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects; D013997:Time Factors
D003508:Cycloheptanes; D005650:Fumarates; D002245:Carbon Dioxide; D000249:Adenosine Monophosphate; D000244:Adenosine Diphosphate; D001537:Bencyclane; D000255:Adenosine Triphosphate