[Modification of toxicity of the calcium antagonist verapamil by depletion of catecholamines (author's transl)].
The acute toxicity of verapamil in mice was nearly doubled by a partial depletion of catecholamines with reserpine 2 mg/kg s.c. 40 and 24 h prior to the experiments. These experiments are in favour of the view that a regulatory effect of the sympathetic nervous systme plays an important role in the treatment with organic calcium antagonists.
D000818:Animals; D002395:Catecholamines / Q000378:metabolism*; D004357:Drug Synergism; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D012110:Reserpine / Q000494:pharmacology; D014700:Verapamil / Q000633:toxicity*
D002395:Catecholamines; D012110:Reserpine; D014700:Verapamil
Anderrun der Toxizität des Calciumantagonisten Verapamil durch Brenzkatechinaminverarmung