title: Inactivation of the chemoattractant folic acid by cellular slime molds and identification of the reaction product.
abstract: Enzymes inactivating the chemoattractants folic acid and pterin were detected in extracellular, intracellular, and particulate fractions obtained from Dictyostelium discoideum strains NC4 and AX-2 and Polysphondylium violaceum. The products of the inactivation reaction were analyzed by thin-layer chromatography and UV spectroscopy. Results obtained indicate that folic acid and pterin were deaminated to 2-deamino folic acid and lumazine, respectively.
mesh_terms: D000619:Aminohydrolases / Q000378:metabolism*; D002458:Cell Fractionation; D002633:Chemotaxis; D004023:Dictyostelium / Q000201:enzymology; D005492:Folic Acid / Q000378:metabolism*; D009235:Myxomycetes / Q000201:enzymology*; D011622:Pterins / Q000378:metabolism
chemical_list: D011622:Pterins; D005492:Folic Acid; D000619:Aminohydrolases