Effect of cholinesterase inhibitors on differentiation of cultured sympathicoblasts.
The 2 cholinesterase inhibitors, eserine and BW 284C 51, inhibited the nerve fibre growth and differentiation of immature sympatheticoblasts at low concentrations. The effect was nerve cell-specific and appeared in the course of the in vitro development, indicating that cholinesterases might play an important role in the early differentiation of sympathicoblasts.
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002478:Cells, Cultured; D002642:Chick Embryo; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D002802:Cholinesterases / Q000378:metabolism; D003864:Depression, Chemical; D005725:Ganglia, Autonomic / Q000166:cytology / Q000196:embryology / Q000201:enzymology
D002800:Cholinesterase Inhibitors; D002802:Cholinesterases