title: Synthesis and biological activity of (2-hydroxy-1-naphthyl)-methylamino acetamido-epicillin and cephradine, and (2-hydroxy-1-naphthyl)-methylacetamido 6-APA.
abstract: Two new penicillins and a new cephalosporin have been synthesized by condensing 2-hydroxy-1-naphthaldehyde with epicillin, 6-aminopenicillanic acid and cephradine, and subsequently reducing the SCHIFF bases with NaBH4. The antimicrobial activities of these compounds are also described.
mesh_terms: D000667:Ampicillin / Q000031:analogs & derivatives* / Q000097:blood / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D001419:Bacteria / Q000187:drug effects; D002511:Cephalosporins / Q000138:chemical synthesis*; D002515:Cephradine / Q000031:analogs & derivatives / Q000097:blood / Q000138:chemical synthesis* / Q000494:pharmacology; D051379:Mice; D010406:Penicillins / Q000097:blood / Q000138:chemical synthesis* / Q000494:pharmacology; D013203:Staphylococcal Infections / Q000188:drug therapy
chemical_list: D002511:Cephalosporins; D010406:Penicillins; D000667:Ampicillin; D002515:Cephradine