Barrel rotation induced by vasopressin and related peptides in rats.
Intraventricular injection of arginine-8-vasopressin and its analogues vasotocin and lysine-8-vasopressin into rat brain evoked a special rotational behavior resembling somatostatin-induced barrel rotation [1]. Oxytocin and oxypressin were less active while vasopressin fragments had no effect. Vasopressin-induced barrel rotation was accompanied by pathological symptoms indicating a disturbance of muscle tone regulation and is considered to be a non-specific and toxic effect. This rotational behavior was not prevented by atropine, propranolol, phentolamine, methylsergide or haloperidol but was reduced by chlorpromazine, probably due to the latter's muscle relaxing activity.
D000818:Animals; D001519:Behavior / Q000187:drug effects*; D004347:Drug Interactions; D006801:Humans; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D013004:Somatostatin / Q000494:pharmacology; D013239:Stereotyped Behavior / Q000187:drug effects*; D014667:Vasopressins / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology*
D014667:Vasopressins; D013004:Somatostatin