title: [Frequency of lethal chromosomal and genome mutations in man].
abstract: According to the cytogenetic studies chromosome anomalies frequency in 209 children who died in the perinatal period was 7.2 per cent. These cases were found to consist of 8 autosome trisomies, 5 anomalies in sex chromosome system, 1 case of triploidy and 1 case of structural reorganization. Accounting for the elimination of chromosome anomalies during the early periods of fetus development, the frequency of chromosome lethals was shown to be 6.44 X 10(-2) in registered pregnancies and 54.89 X 10-2 in conceptions.
mesh_terms: D002869:Chromosome Aberrations / Q000453:epidemiology; D025063:Chromosome Disorders; D005260:Female; D005313:Fetal Death / Q000235:genetics*; D005804:Genes, Lethal; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000235:genetics*; D008297:Male; D009030:Mosaicism; D009154:Mutation; D011247:Pregnancy; D012729:Sex Chromosome Aberrations / Q000453:epidemiology; D014314:Trisomy
vernacular_title: Chastota letal'nykh khromosomnykh i genomnykh mutatsiĭ u cheloveka.