title: [Gastroesophageal reflux in infancy. The physiological basis of management (author's transl)].
abstract: Gastrin has a regulating effect on the complicated closing mechanism of the lower oesophageal sphincter. This hormone produced in G-cells of the pyloric antrum and carried by the blood stream has its greatest effect on the anterior fundus wall, cardias and the lower oesophageal sphincter. Thus, when there is a failure in the closing mechanism of the lower oesophageal sphincter produced by lacking maturity of the oesophageal fibers and the cardias zone, only those surgical procedures using the gastric fundus in order to correct the failure can guarantee a good result, if medical treatment has not been successful. The authors comment on the physiological basis of the treatment, the medical as well as the surgical one, of the gastro-oesophageal reflux.
mesh_terms: D004943:Esophagogastric Junction / Q000503:physiopathology; D005755:Gastrins / Q000502:physiology*; D005764:Gastroesophageal Reflux / Q000601:surgery*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000601:surgery*; D011706:Pyloric Antrum / Q000502:physiology / Q000601:surgery*
chemical_list: D005755:Gastrins
vernacular_title: Reflujo gastroesofágico en la primera infancia. Bases fisiológicas de su tratamiento.