Iron transport in NRK cells synchronized in G(1) by picolinic acid.
NRK cells treated with picolinic acid are arrested in G(1)(G0). After removal of the agent a wave of transferrin-dependent iron uptake was observed only in early G(1). Therefore, iron transport is a primary event in the reinitiation of cell growth and may be connected with subsequent metabolic steps leading to initiation of DNA synthesis.
D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D004247:DNA / Q000096:biosynthesis; D007399:Interphase; D007501:Iron / Q000378:metabolism*; D010848:Picolinic Acids / Q000494:pharmacology*; D051381:Rats; D014168:Transferrin / Q000378:metabolism
D010848:Picolinic Acids; D014168:Transferrin; D004247:DNA; D007501:Iron