[On the dose-effect relation of allopurinol (author's transl)].
The hypuricemic action(y) of 1H-pyrazolo(3,4-d)pyrimidin-4-ol (allopurinol) is dependent on the serum concentration of uric acid (x). After treatment with allopurinol at doses of 300 mg daily for 8 days there exists a highly significant correlation corresponding the equation y = 0.875x + 3.950. At a level of 8 mg/dl without any therapy serum uric acid concentration is expected to decrease by an average of 3 mg/dl if allopurinol is applied at daily doses of 300 mg in a preparation with or without any retarding effect. Following a dose reduction to 150 mg allopurinol daily over a period of 8 days, too, the mean diminution of the hypuricemic action amounts only to 0.43 +/- 0.26 mg/dl (S.D.). In some cases, however, long-term therapy with allopurinol at daily doses of 150 mg is insufficient to guarantee a normuricemic state.
D000328:Adult; D000368:Aged; D000493:Allopurinol / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D003692:Delayed-Action Preparations; D004305:Dose-Response Relationship, Drug; D006073:Gout / Q000188:drug therapy; D006801:Humans; D008875:Middle Aged; D013997:Time Factors; D014527:Uric Acid / Q000097:blood
D003692:Delayed-Action Preparations; D014527:Uric Acid; D000493:Allopurinol
Zur Dosis-Wirkungs-Beziehung von Allopurinol.