A comparison of the distribution, metabolism and excretion of ethylenethiourea in the pregnant mouse and rat.
Pregnant mice and rats were treated by stomach intubation on day 15 g of gestation with 240 mg/kg of ethylenethiourea (ETU) made up in part with radiolabeled ETU. Animals were sacrificed at specific times post-treatment, and maternal tissues, fetus, urine and feces were collected for determination of radioactivity. Maternal and fetal tissue levels of ETU were similar at three hours post treatment; thereafter, the mouse (maternal and fetus) showed much less ETU than the rat. The t1/2 of ETU elimination from the maternal blood was 9.4 and 5.5 hours for the rat and mouse, respectively. Analysis of urine by thin-layer chromatography and radiochromatography revealed that the mouse and rat metabolized ETU by different pathways. Furthermore, the mouse is able to metabolize ETU to a greater extent than the rat.
D000818:Animals; D002250:Carbon Radioisotopes; D002940:Circadian Rhythm; D005031:Ethylenethiourea / Q000008:administration & dosage / Q000378:metabolism* / Q000633:toxicity; D005260:Female; D005333:Fetus / Q000378:metabolism*; D007093:Imidazoles / Q000378:metabolism*; D007553:Isotope Labeling; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D051379:Mice; D009132:Muscles / Q000378:metabolism; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D011270:Pregnancy, Animal; D051381:Rats; D013154:Spleen / Q000378:metabolism; D013462:Sulfur Radioisotopes; D013997:Time Factors
D002250:Carbon Radioisotopes; D007093:Imidazoles; D013462:Sulfur Radioisotopes; D005031:Ethylenethiourea