Dopaminergic pathways in the rat central nervous system and rotational behavior.
Unilateral lesion of substantia nigra or ventral tegmental area causes ipsilateral rotational behaviour after receptor stimulation by apomorphine, whereas contralateral rotations were observed after lesion of globus pallidus. The alterations in dopamine and noradrenaline content of relating structures were determined by radiometric microassay. There is no strong correlation between transmitter depletion and motoric asymmetry. The site and extent of lesion seems to be more determinative to motoric disturbances.
D000818:Animals; D001519:Behavior / Q000502:physiology*; D001923:Brain Chemistry / Q000187:drug effects; D002395:Catecholamines / Q000378:metabolism; D002490:Central Nervous System / Q000502:physiology*; D004298:Dopamine / Q000502:physiology*; D005260:Female; D005917:Globus Pallidus / Q000502:physiology; D006801:Humans; D006892:Hydroxydopamines / Q000494:pharmacology; D051381:Rats; D013239:Stereotyped Behavior / Q000502:physiology*; D013378:Substantia Nigra / Q000502:physiology
D002395:Catecholamines; D006892:Hydroxydopamines; D004298:Dopamine