title: Behavioral effects of low level neonatal lead exposure.
abstract: Rats exposed to lead via maternal milk were tested at various stages of development on a number of behavioral tasks. Beginning at paturition, the dams were given either tap water, 0.02%, or 0.10% lead acetate in the drinking water. Pups from all three groups were weaned to normal chow and tap water at 21 days of age. The mean lead concentration of the dam's blood and of neonatal (20 days of age) brain and blood were all below 50 microgram/100 ml. No significant differences were found between the high lead-exposed group and controls in general as measured by wheel running over a 21 day period beginning at 30 days of age. However, there was a significant difference in wheel running behavior during the first three hr of testing. Both lead-exposed groups were found to display significantly less aggressive behavior as measured by the shock-elicited aggression test. Low level lead exposure had no discernable effect on the acquisition and subsequent reversal of a successive brightness discrimination task. Lead exposure under these conditions appears to affect some aspects of emotional behavior, while having little effect on general activity or cognitive function.
mesh_terms: D000374:Aggression / Q000187:drug effects; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001522:Behavior, Animal / Q000187:drug effects*; D004192:Discrimination, Psychological / Q000187:drug effects; D006801:Humans; D007854:Lead / Q000032:analysis / Q000097:blood / Q000494:pharmacology*; D008297:Male; D008892:Milk / Q000032:analysis; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D013997:Time Factors
chemical_list: D007854:Lead