title: Late recurrence of cancer in the larynx and hypopharynx after irradiation.
abstract: 11 cases of recurrent laryngeal or hypopharyngeal carcinoma, occurring 5 or more years after radiotherapy for carcinoma, are reported. The possible pathological mechanisms involved include persistence of the original carcinoma, second primary due to the original factors, and radiation-induced carcinoma. The last-mentioned possibility is of vital importance and requires further investigation. If radiation-induced carcinoma is as common as some recent series suggest, then primary treatment of T1 laryngeal carcinoma must be re-thought. However, this author believes that convincing evidence is lacking that irradiation is a common cause of late recurrent carcinoma.
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000175:diagnosis / Q000209:etiology / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009381:Neoplasms, Radiation-Induced / Q000175:diagnosis; D010610:Pharyngeal Neoplasms / Q000175:diagnosis / Q000209:etiology / Q000532:radiotherapy*; D013997:Time Factors