[Influence of hydrocortisone on the response to noradrenaline of segments of isolated coronary arteries in the presence of a beta-adrenergic blocking agent].
The effect of hydrocortisone on the noradrenaline-induces contraction, after propranolol, was studied in vitro. Contraction of response to noradrenaline were increased by hydrocortisone. We suggest that the hydrocortisone influence depends on inhibition of catecol-O-metiltransferase (COMT).
D000818:Animals; D002417:Cattle; D003331:Coronary Vessels / Q000187:drug effects*; D004347:Drug Interactions; D006854:Hydrocortisone / Q000494:pharmacology*; D066298:In Vitro Techniques; D009638:Norepinephrine / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology*; D014661:Vasoconstriction / Q000187:drug effects
D011433:Propranolol; D006854:Hydrocortisone; D009638:Norepinephrine
Influenza dell'idrocortisone sulle risposte alla noradrenalina di segmenti di arterie coronarie isolate in presenza di un bloccante beta-adrenergico.