title: [Unexpected anti-inflammatory activity of rigid structures derived from 6-arylpyridazinone antihypertensive agents. II. Synthesis and activity of 5H-indeno(1,2-c)pyridazine and 5H-indeno(1,2-c)pyridazin-3-one].
abstract: The synthesis of 5H-indeno[1,2-c]pyridazine (V) and of some derivatives were reported. The compounds synthesised generally retained the antiinflammatory activity exhibited by the 4,4a-dihydro derivatives of this class, previously tested. Moreover (V) showed analgesic and antipyretic properties higher than those of acetylsalicylic acid.
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D007192:Indenes / Q000138:chemical synthesis*; D051379:Mice; D011724:Pyridazines / Q000138:chemical synthesis*; D051381:Rats
chemical_list: D000893:Anti-Inflammatory Agents; D007192:Indenes; D011724:Pyridazines
vernacular_title: Inattesa attività antiinflammatoria di strutture rigide derivate da 6-arilpiridazinoni antiipertensivi. Nota II. Sintesi e attività di 5H-indeno[1,2-c]piridazine e 5H-indeno-[1,2-c]piridazin-3-oni.