title: Proinsulin and A-component antibodies in diabetics after long-term monocomponent insulin treatment.
abstract: In newly diagnosed diabetics treated with Monotard (porcine monocomponent (MC) Lente insulin) for five years, no antibodies against porcine or bovine proinsulin were observed, but 2 of 13 subjects developed a-component antibodies. In newly diagnosed diabetics, treatment for the same period with conventional Lente insulin induced both proinsulin and a-component antibodies (in 5 and 8 of 10 cases, respectively). In 31 patients transferred from conventional Lente to Monotard, proinsulin and a-component antibody levels were significantly lower than in 22 patients maintained on conventional Lente after the 5-year follow-up period. No significant differences were noted between bovine and procine proinsulin antibodies. Insulin antibody production was similar to that of proinsulin antibody.
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D002417:Cattle; D002648:Child; D003920:Diabetes Mellitus / Q000097:blood* / Q000188:drug therapy / Q000276:immunology; D005260:Female; D006801:Humans; D007330:Insulin Antibodies / Q000032:analysis*; D049528:Insulin, Long-Acting / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011384:Proinsulin / Q000097:blood*; D013552:Swine; D013997:Time Factors
chemical_list: D007330:Insulin Antibodies; D049528:Insulin, Long-Acting; D011384:Proinsulin