Topical hemostatic agents for bone bleeding in humans. A quantitative comparison of gelatin paste, gelatin sponge plus bovine thrombin, and microfibrillar collagen.
The three topical hemostatic agents--gelatin paste, microfibrillar collagen, and gelatin sponge soaked in thrombin--individually were effective in reducing bleeding from cancellous bone, as tested on the femoral surface of trochanteric osteotomies during total hip replacement. During a three-minute interval, the spontaneous reduction in bleeding in eight control hips to which no agent was applied was 11 per cent. Gelatin paste gave a reduction of 85 per cent; gelatin sponge soaked in thrombin, a reduction of 75 per cent; and microfibrillar collagen, a reduction of 47 per cent. None of these agents interfered with healing of the trochanteric osteotomy.
D000287:Administration, Topical; D000818:Animals; D001847:Bone Diseases / Q000188:drug therapy*; D002417:Cattle; D003094:Collagen / Q000008:administration & dosage / Q000627:therapeutic use; D005780:Gelatin / Q000008:administration & dosage / Q000627:therapeutic use; D005781:Gelatin Sponge, Absorbable / Q000008:administration & dosage / Q000627:therapeutic use; D006470:Hemorrhage / Q000188:drug therapy*; D006490:Hemostatics / Q000008:administration & dosage* / Q000627:therapeutic use; D006621:Hip Joint / Q000601:surgery; D006801:Humans; D009824:Ointments; D010027:Osteotomy; D013917:Thrombin / Q000008:administration & dosage / Q000627:therapeutic use
D006490:Hemostatics; D009824:Ointments; D005780:Gelatin; D003094:Collagen; D013917:Thrombin