[Synthesis of the bis(S-methoxycarbonylthio)-B-chain of beef insulin (author's transl)].
The bis(S-methoxycarbonylthio)-B-chain of beef insulin was synthesized from B-chain bis(S-sulfonate) and methoxycarbonyl-sulfenylchloride and reacted with thioglycolic acid as well as with cysteine in acidic solution to the corresponding unsymmetrical disulfides in 80% yield.
D000818:Animals; D002417:Cattle; D003545:Cysteine; D007202:Indicators and Reagents; D007328:Insulin / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D008722:Methods
D007202:Indicators and Reagents; D007328:Insulin; D003545:Cysteine
Darstellung von Bis(S-methoxycarbonylthio)-B-Kette des Rinderinsulins.