Study of the influence of certain antitumor preparations on the population of hematopoietic stem cells.
The influence of antitumor preparations 1,2-bisdiazoacetylethane (diazan) and N-nitroso-N-methylurea (NMU) on the inhibition of colony formation after sublethal irradiation and on migration after nonuniform irradiation of mice was investigated by methods of endogenous cloning of hematopoietic stem cells. It was shown that both preparations in the therapeutic doses used in experimental oncology (diazan 150 mg/kg, NMU 8 mg/kg) have no mitostatic effect on the hematopoietic stem cells, while NMU also does not influence their migration. Diazan somewhat stimulated the migration process.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002464:Cell Migration Inhibition; D002999:Clone Cells; D003979:Diazonium Compounds / Q000494:pharmacology*; D006412:Hematopoietic Stem Cells / Q000187:drug effects* / Q000528:radiation effects; D008770:Methylnitrosourea / Q000494:pharmacology*; D051379:Mice; D009607:Nitrosourea Compounds / Q000494:pharmacology*; D013386:Succinates / Q000494:pharmacology*
D000970:Antineoplastic Agents; D003979:Diazonium Compounds; D009607:Nitrosourea Compounds; D013386:Succinates; C000279:diazan; D008770:Methylnitrosourea