title: [On the pharmacology of Etozolin (author's transl)].
abstract: Ethyl (Z)-(3-methyl-4-oxo-5-piperidino-thiazolidin-2-ylidene)acetate (etozolin, Gö 687, Elkapin) is a diuretic with a new chemical structure. Animal experiments with etozolin showed low toxicity, potent diuretic and saluretic properties with a mild onset of action. A marked antihypertensive effect was found in long-term experiments in hypertensive rats. In investigations concerning general pharmacology etozolin showed no effects which stand against its use as a diuretic.
mesh_terms: D000818:Animals; D001646:Bile / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D004231:Diuresis / Q000187:drug effects; D004232:Diuretics / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D004285:Dogs; D005704:Gallbladder / Q000502:physiology; D006973:Hypertension / Q000188:drug therapy; D010880:Piperidines / Q000494:pharmacology; D051381:Rats; D013844:Thiazoles / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D014882:Water-Electrolyte Balance / Q000187:drug effects
chemical_list: D004232:Diuretics; D010880:Piperidines; D013844:Thiazoles
vernacular_title: Zur Pharmakologie von Etozolin.