Anti-estrogen inhibition of testosterone-stimulated aggression in mice.
Testosterone-stimulated intermale aggression in castrated mice can be reversibly inhibited by anti-estrogen administration suggesting that estrogen formation and actions in the brain may be required for testosterone's behavioral actions.
D000374:Aggression / Q000187:drug effects*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002369:Castration; D004965:Estrogen Antagonists / Q000494:pharmacology*; D006801:Humans; D008297:Male; D051379:Mice; D009594:Nitromifene / Q000494:pharmacology*; D011759:Pyrrolidines / Q000494:pharmacology*; D013739:Testosterone / Q000037:antagonists & inhibitors*
D004965:Estrogen Antagonists; D011759:Pyrrolidines; D013739:Testosterone; D009594:Nitromifene