[Encephalopathy due to vincristine sulfate (author's transl)].
A cytotoxic effect by vincristine sulfate on the cerebral cortex is claimed in literature. In 188 children treated with vincristine we saw no so called "Vincristine-induced Encephalopathy". The proportional risk of vincristin-induced cerebral complications amount to 1%, as demonstrated by various authors. In 67 children investigated 5 weeks up to 2 years after last vincristine-injection we found no EEG-tracing, which could be discussed as a vincristine-induced finding.
D001927:Brain Diseases / Q000139:chemically induced* / Q000175:diagnosis; D002648:Child; D004569:Electroencephalography; D006801:Humans; D013997:Time Factors; D014750:Vincristine / Q000009:adverse effects*
D014750:Vincristine
Zur Frage der Encephalotoxizität des Vincristin (EEG-Befunde bei Langzeitüberlebenden nach Leukämien und soliden Tumoren im Kindesalter, die mit Vincristin behandelt wurden).