[Effect of chronic stimulation of rats with intact and deafferented hypothalamuses on lipid metabolism and the adrenal cortex].
Chronic irritation of the falsely operated rats and those with the deafferentated hypothalamus led to reduction of total blood cholesterol and the accumulation of triglycerides in the liver. Dexamethasone administration was accompanied by an increase of blood cholesterol and triglycerides and the triglyceride accumulation in the liver. The action of dexamethasone was more pronounced in the animals with the deafferentated hypothalamus. The rate of 11-oxycorticosteroid secretion into the adrenal vein is reduced in the latter.
D015062:11-Hydroxycorticosteroids / Q000378:metabolism*; D000302:Adrenal Cortex / Q000378:metabolism*; D000311:Adrenal Glands / Q000378:metabolism*; D000818:Animals; D002784:Cholesterol / Q000378:metabolism; D003907:Dexamethasone / Q000494:pharmacology*; D006801:Humans; D007031:Hypothalamus / Q000502:physiology*; D007103:Immobilization; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D009475:Neurons, Afferent / Q000502:physiology; D051381:Rats; D013315:Stress, Psychological / Q000502:physiology*; D014280:Triglycerides / Q000378:metabolism
D015062:11-Hydroxycorticosteroids; D014280:Triglycerides; D003907:Dexamethasone; D002784:Cholesterol
Vliianie khronicheskogo razdrazheniia krys s intaktnym i deafferentirovannym gipotalamusom na lipidnyĭ obmen i koru nadpochechnikov