[Effect of calcitonin on various stress ulcer models in the rat].
The preventive effect of calcitonin (10 microgram/kg subcutaneously) on stress ulcer was examined in 135 rats. Three stress models were used: (1) immobilization, (2) immobilization and ketamine, (3) hypovolemia. Significantly lowered lesion rates under calcitonin were found in immobilization stress and hypovolemia models (14%, resp. 16%), compared with controls (78%, resp. 56%). Reduction of the severe lesions of the mucous membrane was the only significantly different result in the combination of immobilization and ketamine.
D000818:Animals; D002116:Calcitonin / Q000008:administration & dosage*; D004195:Disease Models, Animal; D005753:Gastric Mucosa / Q000187:drug effects; D006801:Humans; D007103:Immobilization; D008297:Male; D010437:Peptic Ulcer / Q000209:etiology / Q000517:prevention & control*; D051381:Rats; D012771:Shock, Hemorrhagic / Q000150:complications; D013315:Stress, Psychological / Q000502:physiology*
D002116:Calcitonin
Die Wirkung von Calcitonin bei verschiedenen Stressulkusmodellen der Ratte.