Inhibition of esterase and amidase activities of alpha- and beta-thrombin in the presence of antithrombin III and heparin.
Inhibition of the esterase and amidase activities of bovine alpha- and beta-thrombin in the presence of antithrombin III and heparin has been studied. It was found that both the esterase and amidase activities of alpha-thrombin were inhibited by antithrombin III and the reactions were accelerated by heparin. The inhibition of amidase and esterase activities of beta-thrombin by antithrombin III has also been demonstrated. Heparin however did not increase the rate of inactivation of the enzyme.
D000581:Amidohydrolases / Q000037:antagonists & inhibitors; D000813:Anilides; D000818:Animals; D000990:Antithrombin III / Q000494:pharmacology*; D002417:Cattle; D004357:Drug Synergism; D004950:Esterases / Q000037:antagonists & inhibitors; D006493:Heparin / Q000494:pharmacology*; D007700:Kinetics; D009842:Oligopeptides / Q000378:metabolism; D013917:Thrombin / Q000037:antagonists & inhibitors / Q000378:metabolism*; D014106:Tosylarginine Methyl Ester / Q000378:metabolism
D000813:Anilides; D009842:Oligopeptides; D000990:Antithrombin III; D006493:Heparin; D014106:Tosylarginine Methyl Ester; D004950:Esterases; D013917:Thrombin; D000581:Amidohydrolases