Involvement of cytoskeletal structures in nerve-growth-factor-mediated induction of ornithine decarboxylase.
Induction of ornithine decarboxylase elicited in response to nerve-growth factor in target organs is greatly decreased by preincubation of these tissues with cytoskeletal poisons such as vinblastine, diamide, cytochalasin B and colchicine. These results are interpreted as evidence for the involvement of receptor-associated cytoskeletal structures in mediating the nerve-growth-factor-specific induction of ornithine decarboxylase.
D000818:Animals; D002262:Carboxy-Lyases / Q000096:biosynthesis*; D002462:Cell Membrane / Q000187:drug effects / Q000201:enzymology; D003078:Colchicine / Q000494:pharmacology; D003571:Cytochalasin B / Q000494:pharmacology; D003593:Cytoplasm / Q000502:physiology*; D003599:Cytoskeleton / Q000502:physiology*; D003958:Diamide / Q000494:pharmacology; D004790:Enzyme Induction / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008870:Microtubules / Q000502:physiology*; D009414:Nerve Growth Factors / Q000494:pharmacology*; D009955:Ornithine Decarboxylase / Q000096:biosynthesis*; D014747:Vinblastine / Q000494:pharmacology
D009414:Nerve Growth Factors; D003958:Diamide; D003571:Cytochalasin B; D014747:Vinblastine; D002262:Carboxy-Lyases; D009955:Ornithine Decarboxylase; D003078:Colchicine