[Cortisol 6beta-hydroxylation pathway in the early neonatal period].
The method of thin-layer chromatography was applied to the study of renal excretion of 6beta-hydroxycortisol in 56 healthy neonates whose mothers were sufferin from late toxemia and in  9 women with 39-40 weeks of gestation. The proportional of 6beta-hydroxycortisol in the sum total of cortisol metabolites excreted in neonates the first week after birth was found to constitute 23.5-26.9%. However, as in adults the predominant route of cortisol metabolism was formation of tetrahydroderivatives whose proportion in the sum total of the excreted compounds constituted 47.7-55.0%. A high 6beta-hydroxycortisol excretion level was noted at the end of pregnancy. Equal amounts of 6beta-hydroxycortisol were excreted in healthy neonates and in children whose mothers were suffering from late toxemia of pregnancy. 6beta-hydroxycortisol formation is the usual independent route of cortisol metabolism in neonates the first week after birth.
D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000031:analogs & derivatives / Q000378:metabolism* / Q000652:urine; D006900:Hydroxylation; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange; D011225:Pre-Eclampsia / Q000378:metabolism*; D011247:Pregnancy
D006854:Hydrocortisone
Put' 6beta-gidroksilirovaniia kortizola v rannem neonatal'nom periode.