[The inhibition of prostaglandin induced uterine contractions by diazoxide in vitro (author's transl)].
The tocolytic efficiency of Diazoxide, a benzothiadiazine derivative with pronounced musculotropic action, was tested on the isolated uteri of non-gravid and gravid rats. Regular uterine contractions were induced by the prostaglandines E2 and F2 alpha. Their amplitude and frequency could be suppressed totally or subtotally. Contraction intervals lasted 4--22 min. The basal tone was reduced in most cases.
D000818:Animals; D003981:Diazoxide / Q000494:pharmacology*; D005260:Female; D066298:In Vitro Techniques; D011247:Pregnancy; D011448:Prostaglandin Antagonists; D011458:Prostaglandins E / Q000037:antagonists & inhibitors / Q000494:pharmacology; D011460:Prostaglandins F / Q000037:antagonists & inhibitors / Q000494:pharmacology; D051381:Rats; D014590:Uterine Contraction / Q000187:drug effects*
D011448:Prostaglandin Antagonists; D011458:Prostaglandins E; D011460:Prostaglandins F; D003981:Diazoxide
Die Hemmung Prostaglandin induzierter Wehen mit Diazoxide in Vitro