Imidazole myopathy. Production of the myopathy and its dependence on acetylcholine.
An acetylcholine-mediated myopathy has been produced in the soleus muscle of the rat by the daily injection of imidazole, a compound that accelerates the metabolism of adenosine 3':5' cyclic phosphate by activating the enzyme phosphodiesterase. The imidazole-treated muscles were found to have a lowered resting membrane potential. This study suggests that a decrease in resting membrane potential may make skeletal muscle more vulnerable to necrosis by acetylcholine released during normal activity.
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006146:Guanidines / Q000633:toxicity; D006426:Hemicholinium 3 / Q000627:therapeutic use; D007093:Imidazoles / Q000633:toxicity*; D008564:Membrane Potentials; D009121:Muscle Denervation; D009132:Muscles / Q000473:pathology; D009468:Neuromuscular Diseases / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control; D009469:Neuromuscular Junction / Q000378:metabolism; D051381:Rats
D006146:Guanidines; D007093:Imidazoles; D006426:Hemicholinium 3; D000109:Acetylcholine