[Analysis of the effect of morphine on the reproductive capacity and immunological status of mice].
Embryogenesis process is disturbed under the action of prolonged morphine administration to CBA mice. Simultaneously a decrease in the level of antibody-synthesizing cells and a significant reduction in the cooperating interaction of T and B lymphocytes in response to the injection of sheep red blood cells are noted. At the same time stimulation of bone marrow cells and specific sensitization of MIF-inducers to the antigen from the brain of morphinized mice are revealed.
D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects*; D003864:Depression, Chemical; D005260:Female; D005298:Fertility / Q000187:drug effects*; D008211:Lymphocyte Cooperation / Q000187:drug effects; D051379:Mice; D009020:Morphine / Q000009:adverse effects*; D013154:Spleen / Q000166:cytology
D009020:Morphine
Analiz deĭstviia morfina na reproduktivnuiu sposobnost' i immunologicheskiĭ status mysheĭ.