Iotroxamide--a new intravenous cholangiographic agent. Comparison with iodipamide and the effect of bile salts.
The maximum biliary excretion rate of iotroxamide was found to be significantly greater than that of iodipamide in bile-fistula dogs. High bile salt excretion rates had no effect on the rate of biliary excretion of either compound, but the choleresis associated with greater bile salt excretion reduced the biliary concentration of both agents. Both are potent choleretics, stimulating about 23.5 ml of bile per mmole of contrast agent excreted in bile. This obligatory coupling of the contrast agents with water as they are excreted in bile imposes a limit on the maximum concentration that can be achieved in bile. Since iotroxamide is excreted more rapidly in bile than iodipamide for any equimolar plasma concentration, it may be a superior contrast agent for intravenous cholangiography.
D000818:Animals; D001646:Bile / Q000378:metabolism; D001647:Bile Acids and Salts / Q000378:metabolism* / Q000494:pharmacology; D001658:Biliary Fistula / Q000378:metabolism; D002756:Cholagogues and Choleretics / Q000378:metabolism; D002758:Cholangiography; D004285:Dogs; D007458:Iodipamide / Q000031:analogs & derivatives* / Q000378:metabolism*; D007471:Ioglycamic Acid / Q000378:metabolism; D007700:Kinetics; D008954:Models, Biological; D013656:Taurocholic Acid / Q000494:pharmacology; D014283:Triiodobenzoic Acids / Q000378:metabolism
D001647:Bile Acids and Salts; D002756:Cholagogues and Choleretics; D014283:Triiodobenzoic Acids; D013656:Taurocholic Acid; D007471:Ioglycamic Acid; D007458:Iodipamide