[Production of granules with controlled drug release rate (author's transl)].
A procedure for microgranulation is described (cf. [7]) which is based on the use of formaldehyde-treated gelatin. The drug (Drotaverin: No-Spa) contained in the matrix is released, dependently of the formaldehyde concentration in the matrix, at a predetermined rate. The release (first-order kinetics) is rapid at low formaldehyde concentrations, and slower at higher formaldehyde concentrations.
D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D005557:Formaldehyde; D007700:Kinetics; D011208:Powders; D012995:Solubility
D003692:Delayed-Action Preparations; D011208:Powders; D005557:Formaldehyde
Herstellung eines Granulates mit regulierter Wirkstoffabgabegeschwindigkeit.