Effects of intrastriatal injections of atropine and methacholine on the apomorphine-induced gnawing in the rabbit.
To find out the anatomical location of the target point of cholinergic-dopaminergic equilibrium, atropine (40 microng) or methacholine (10 microng) were injected through previously implanted cannulas into various places of caudate nucleus and putamen of the rabbit, and the effect of the injections on stereotype gnawing induced by subcutaneously or intravenously administered apomorphine (1--2 mg/kg) was assessed. The intensity of gnawing was measured using a special apparatus, counting each bite. Atropine inhibited the stereotype, while metacholine potentiated it. The effects were evident with the method used, but difficult to reveal with the classical method of assessing the intensity of stereotyped behavior, based on visual observation. The results suggest that the striatum is not a target point for the cholinergic component of the cholinergic-dopaminergic equilibrium in the central nervous system.
D000818:Animals; D001058:Apomorphine / Q000008:administration & dosage / Q000494:pharmacology*; D001285:Atropine / Q000008:administration & dosage / Q000494:pharmacology*; D001519:Behavior / Q000187:drug effects*; D002421:Caudate Nucleus; D004347:Drug Interactions; D006801:Humans; D007267:Injections; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D008297:Male; D008688:Methacholine Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D011699:Putamen; D011817:Rabbits; D013239:Stereotyped Behavior / Q000187:drug effects*
D008688:Methacholine Compounds; D001285:Atropine; D001058:Apomorphine