Pardoxical cytotoxic effect of antisera used in diagnostic virology. Brief report.
Rabbit antisera prepared against adenovirus-infected or uninfected HEK cells showed a high degree of cytotoxicity towards HeLa and other human cell cultures, while antisera prepared against infected HeLa cells did not. The toxic activity was independent of complement; it could be removed by adsorption to HEK monolayers.
D000260:Adenoviruses, Human / Q000302:isolation & purification*; D000818:Animals; D002460:Cell Line; D003601:Cytotoxicity Tests, Immunologic; D006801:Humans; D007106:Immune Sera; D009500:Neutralization Tests; D011817:Rabbits / Q000276:immunology
D007106:Immune Sera