title: Therapeutic effects of various concentrations of lincomycin in drinking water on experimentally transmitted swine dysentery.
abstract: Three experimental studies were conducted in 232 growing pigs (8 to 12 weeks old) to evaluate the therapeutic effects of various concentrations of lincomycin in drinking water, against swine dysentery experimentally transmitted, by oral inoculation or by contact-commingling exposure. Four or 5 concentrations of lincomycin were used in each experiment (132, 66, 33, 16.5 or 0.0 mg/L of drinking water). Medication was initiated 7 to days after exposure and was continued for 6 to 10 days. Both methods of exposure were capable of transmitting the disease successfully. A more marked dose response was noticed in pigs inoculated orally than in pigs that were exposed by contact. All concentrations of lincomycin were effective for the treatment of swine dysentery by oral or by contact exposure. At the smaller concentration of 16.5 mg/L of drinking water, lincomycin was less effective for treating the disease than it was at greater concentrations. The suggested optimal concentration was 33 mg of lincomycin/L of drinking water for the treatment of swine dysentery.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004403:Dysentery / Q000188:drug therapy / Q000517:prevention & control / Q000662:veterinary*; D005260:Female; D008034:Lincomycin / Q000008:administration & dosage* / Q000627:therapeutic use; D008297:Male; D013552:Swine; D013553:Swine Diseases / Q000188:drug therapy* / Q000517:prevention & control; D014211:Treponemal Infections / Q000188:drug therapy / Q000517:prevention & control / Q000662:veterinary; D014867:Water
chemical_list: D014867:Water; D008034:Lincomycin