Lung tumor response in mice to metals and metal salts.
Two studies tested the ability of metals and their salts to produce lung tumors in strain A mice. Of 13 compounds examined, lead subacetate, manganous sulfate, molybdenum trioxide, and nickelous acetate elicited a weakly carcinogenic response following intraperitoneal injection. Nine metallic compounds were negative. There was no evidence of cocarcinogenic effect between metals and the chemical carcinogen, 3-methylcholanthrene. On the basis of these and other data, recommendation is made for further investigations in metal carcinogenesis.
D000818:Animals; D003043:Cocarcinogenesis; D007274:Injections, Intraperitoneal; D007854:Lead / Q000633:toxicity; D008175:Lung Neoplasms / Q000139:chemically induced*; D020149:Manganese Poisoning; D008670:Metals / Q000633:toxicity*; D008748:Methylcholanthrene; D051379:Mice; D008805:Mice, Inbred A; D008982:Molybdenum / Q000633:toxicity; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009532:Nickel / Q000633:toxicity
D008670:Metals; D007854:Lead; D008748:Methylcholanthrene; D009532:Nickel; D008982:Molybdenum