The effects of emeprone on intravesical and intra-urethral pressure in women with urgency incontinence.
By use of a sensitive technique, simultaneous registration of intravesical and intra-urethral pressure changes was performed in 14 patients with urgency incontinence before and after intramuscular or oral administraiton of emeprone. The serum concentrations of the drug at different times after administration were also measured. After intramuscular injection, emeprone caused an increased bladder capacity in all the patients, and they experienced urge at larger bladder volumes. The urethral pressure was little affected. Thus, there were no significant changes of the maximum urethral pressure or of the functinal length of the urethra. Eight out of nine patients got a residual urine. After oral administration of emeprone, two out of five patients got an increased bladder capacity, and experienced urge at a larger bladder volume. They had no residual urine. In the patients receiving emeprone intramuscularly, the maximum plasma concentrations ranged from 1171 ng/ml to 378 ng/ml; they were found after 15 or 30 min. After oral intake, the maximum concentrations ranged from 36 ng/ml to 64 ng/ml and were found after 60 to 180 min. The results suggest that emeprone has actions mainly on the bladder; the effects on the urethra seem to be small.
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D004629:Emepronium / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D011312:Pressure; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*; D014521:Urethra / Q000187:drug effects* / Q000503:physiopathology; D014546:Urinary Catheterization; D014549:Urinary Incontinence / Q000188:drug therapy* / Q000503:physiopathology
D000644:Quaternary Ammonium Compounds; D004629:Emepronium