Does androgen influence prolactin secretion?
In both intact and castrated male and female rats, administration of the A-ring reduced androgen, dihydrotestosterone (DHT), consistently failed to stimulate prolactin (PRL) secretion although it inhibited LH release and, in males, stimulated ventral prostate growth. In intact females, but not in the other types of rat, DHT actually suppressed PRL release. These findings do not support generalizations, based entirely on findings with testosterone, that both "androgens" and estrogens exert stimulatory actions on PRL secretion. The distinct stimulatory effects of testosterone and its esters on PRL secretion seem attributable, not to their androgenic actions per se, but to the ability of testosterone to form estrogenic metabolites. This ability does not appear to be shared by the "pure" androgen, DHT.
D000818:Animals; D002369:Castration; D013196:Dihydrotestosterone / Q000494:pharmacology*; D004343:Drug Implants; D004958:Estradiol / Q000031:analogs & derivatives / Q000494:pharmacology; D004971:Estrus; D005260:Female; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D011247:Pregnancy; D011388:Prolactin / Q000097:blood / Q000378:metabolism*; D011467:Prostate / Q000187:drug effects / Q000502:physiology; D051381:Rats; D012737:Sex Factors; D013739:Testosterone / Q000031:analogs & derivatives / Q000494:pharmacology
D004343:Drug Implants; D013196:Dihydrotestosterone; D013739:Testosterone; D004958:Estradiol; D011388:Prolactin; D007986:Luteinizing Hormone