[Determination of human blood and urine progestins by the method of competitive protein binding on the basis of guinea pig transprogestin].
The use as a testing system of transprogestin or of progesterone-binding protein (obtained from a pregnant guinea pig) with a high specificity to progesterone and a number of its affiliated metabolites increased the sensitivity of the method considerably, permitting to determine progestins in the blood and urine of nonpregnant women (at various phases of the sexual cycle) and in men. Dynamics of the given progestins in the urine correlates with the changes of their blood level and permits complete and objective assessment of the ovarian and placental functions in women with various physiological conditions.
D000328:Adult; D000818:Animals; D001667:Binding, Competitive; D002855:Chromatography, Thin Layer; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D008297:Male; D008598:Menstruation; D049590:Postpartum Period; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D011376:Progesterone-Binding Globulin; D011372:Progestins / Q000097:blood / Q000378:metabolism* / Q000652:urine; D011485:Protein Binding; D012737:Sex Factors
D011376:Progesterone-Binding Globulin; D011372:Progestins
Opredelenie progestinov v krovi i moche u liudeĭ metodom konkurentnogo sviazyvaniia belkami na osnove transprogestina morskoĭ svinki.