title: Inhibition of Dictyostelium discoideum beta-glucosidase by purines.
abstract: beta-Glucosidase of Dictyostelium discoideum is inhibited by purines in the following order: adenine greater than adenosine greater than 6-methylaminopurine greater than hypoxanthine greater than inosine greater than purine greater than guanosine. Adenine inhibits activity by 50% at 1 to 2 mM. The kinetics are complex because the enzyme is stimulated by substrate and inhibited by glucose.
mesh_terms: D000225:Adenine / Q000494:pharmacology; D000241:Adenosine / Q000494:pharmacology; D004023:Dictyostelium / Q000201:enzymology*; D005947:Glucose / Q000494:pharmacology; D005959:Glucosidases / Q000037:antagonists & inhibitors*; D006151:Guanosine / Q000494:pharmacology; D007042:Hypoxanthines / Q000494:pharmacology; D007288:Inosine / Q000494:pharmacology; D007700:Kinetics; D009235:Myxomycetes / Q000201:enzymology*; D011687:Purines / Q000494:pharmacology*
chemical_list: D007042:Hypoxanthines; D011687:Purines; D006151:Guanosine; D007288:Inosine; D005959:Glucosidases; D005947:Glucose; D000225:Adenine; D000241:Adenosine