title: Procaine, lidocaine, and ketamine inhibit histamine-induced contracture of guinea pig tracheal muscle in vitro.
abstract: In vitro experiments using guinea pig tracheal smooth muscle were performed to compare the relaxant properties of procaine, lidocaine, and ketamine following contracture induced by histamine. Procaine produced a spasmolytic effect in a dose-related manner. In the doses tested, relaxation induced by procaine was more pronounced than that produced by either lidocaine or ketamine, although the latter 2 drugs also had a significant spasmolytic effect.
mesh_terms: D000772:Anesthesia, Local; D000818:Animals; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D006632:Histamine; D066298:In Vitro Techniques; D007649:Ketamine / Q000494:pharmacology*; D008012:Lidocaine / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects; D011343:Procaine / Q000494:pharmacology*; D014132:Trachea / Q000187:drug effects*
chemical_list: D011343:Procaine; D007649:Ketamine; D006632:Histamine; D008012:Lidocaine