Reduction by thiopental of the slow-channel-mediated action potential of canine papillary muscle.
The negative inotropic effect of thiopental was examined on the canine papillary muscle. The slow-channel-mediated action potential was induced by 5mM of caffeine in high-K (27 mM) Tyrode solution. The drug reduced the slow action potential and the twitch tension, suggesting a reduction in the slow inward current.
D000200:Action Potentials / Q000187:drug effects*; D000818:Animals; D002110:Caffeine; D004285:Dogs; D008564:Membrane Potentials; D010210:Papillary Muscles / Q000187:drug effects* / Q000502:physiology; D013874:Thiopental / Q000494:pharmacology*
D002110:Caffeine; D013874:Thiopental