title: Modification of hepatotoxic effects of aflatoxin B1 in rabbits by immunization.
abstract: Reduction of acute toxic effect of aflatoxin B1 was achieved by immunizing the rabbits with small amounts of bovine serum albumin-aflatoxin B1 conjugate. Rabbits after immunization showed lower mortality, near normal serum isocitric dehydrogenase activity, no abnormality in livers when challenged with a single dose of aflatoxin B1. The results suggest that immunization might be used prophylactically against aflatoxicosis.
mesh_terms: D000348:Aflatoxins / Q000276:immunology*; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D007114:Immunization; D007521:Isocitrate Dehydrogenase / Q000097:blood; D011817:Rabbits; D012710:Serum Albumin, Bovine / Q000276:immunology
chemical_list: D000348:Aflatoxins; D012710:Serum Albumin, Bovine; D007521:Isocitrate Dehydrogenase