[Behaviour of asbestos fibres in the respiratory system as revealed by animal experiments (author's transl)].
By comparing the evolution of chrysotile and amosite fibres in rat lungs, more rapid clearance was found in the case of chrysotile. The rate of chrysotile clearance is strongly influenced by the size factor. The two varieties of asbestos also differ in their chemical behaviour in the lung. The evolution of chrysotile fibers in vivo is characterized by progressive decrease in magnesium content, while silicium retained in the fibre skeleton is practically not eliminated. Transport of fibers from the lungs to the lymph-nodes, the parietal pleura and the diaphragm also differs with the two asbestos varieties. From fibre counts with the electron microscope, chrysotile was more rapidly eliminated from the lungs than amosite. The concentration is higher with amosite in the lymph-nodes, and with chrysotile in the diaphragm. This last result confirms observations made on human lungs.
D000818:Animals; D001194:Asbestos / Q000378:metabolism*; D001195:Asbestosis / Q000378:metabolism; D001692:Biological Transport; D008168:Lung / Q000378:metabolism*; D008198:Lymph Nodes / Q000378:metabolism; D008657:Metabolic Clearance Rate; D010994:Pleura / Q000378:metabolism; D051381:Rats
D001194:Asbestos
Etude expérimentale du devenir des fibres d'amiante dans l'appareil respiratoire.