title: [Studies on the influence of piprozoline on the microsomal enzyme system of the rat liver (author's transl)].
abstract: Studies of hexobarbital sleeping time in rats showed that only a very high dosage of ethyl(Z)-(3-ethyl-4-oxo-5-piperidino-thiazolidin-2-ylidene)-acetate (piprozoline, Gö 919, Problin) (500 mg/kg) produced a weak interaction with the metabolism of hexobarbital; no signs of any induction of the oxidative enzyme system were observed until 4 days after pre-treatment with 3 X 250 mg/kg. Determinations of the in vitro activity of hepatic microsomal enzymes after several days pre-treatment of male Wistar rats with 2 X 250 mg piprozoline/kg per day showed that piprozoline has only a slight inductive effect on some of the enzymes of the oxidative system. Some of the glucuronidation reactions tested showed marked increases.
mesh_terms: D000818:Animals; D002756:Cholagogues and Choleretics / Q000494:pharmacology*; D004790:Enzyme Induction / Q000187:drug effects; D005965:Glucuronates / Q000378:metabolism; D006591:Hexobarbital / Q000378:metabolism / Q000494:pharmacology; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D010088:Oxidoreductases / Q000378:metabolism; D010880:Piperidines / Q000494:pharmacology; D051381:Rats; D012890:Sleep / Q000187:drug effects; D013844:Thiazoles / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D002756:Cholagogues and Choleretics; D005965:Glucuronates; D010880:Piperidines; D013844:Thiazoles; D006591:Hexobarbital; D010088:Oxidoreductases
vernacular_title: Untersuchungen zum Einfluss von Piprozolin auf das mikrosomale Enzymsystem der Rattenleber