Oestrogenic activity of oestradiol-decanoate after oral administration to rodents.
Oestradiol-decanoate, dissolved in arachis oil and orally administered to rodents, produces oestrogenic effects. Compared on a molecular basis the ester has 0.1-1.0 times the activity of ethinyl oestradiol, dependent on the species and the parameter studied. The effects of oestradiol-decanoate are less or absent when the oil is omitted. It is likely that absorption of the steroid ester takes place via the intestinal lymphatics in conjunction with the oil.
D000284:Administration, Oral; D000818:Animals; D002369:Castration; D006224:Cricetinae; D003651:Decanoates / Q000494:pharmacology; D004958:Estradiol / Q000008:administration & dosage / Q000494:pharmacology*; D004997:Ethinyl Estradiol / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D006065:Gonadotropins, Pituitary / Q000378:metabolism; D006168:Guinea Pigs; D051379:Mice; D009821:Oils / Q000008:administration & dosage; D009929:Organ Size / Q000187:drug effects; D010060:Ovulation / Q000187:drug effects; D051381:Rats; D011960:Receptors, Estrogen / Q000187:drug effects*; D014599:Uterus / Q000187:drug effects; D014621:Vagina / Q000187:drug effects
D003651:Decanoates; D006065:Gonadotropins, Pituitary; D009821:Oils; D011960:Receptors, Estrogen; D004997:Ethinyl Estradiol; D004958:Estradiol