Relationship between concentration of prostaglandins E and F in the regulation of ovum transport in rabbits.
Prostaglandin E and F levels were measured by a radioimmunoassay technique in different parts of the rabbit fallopian tube treated with indomethacin and in untreated rabbit at 0, 24, 48 and 72 hours after Human Chorionic Gonadotrophin (HCG) administration. The results indicate a significant rise in the levels of PGE and fall in the levels of PGF throughout the isthmus at 48 hours and in the distal isthmus at 72 hours in the untreated rabbits. In the indomethacin treated rabbits, PGF levels were reduced relatively more than PGE levels in different parts of the rabbit fallopian tube at various time intervals after HCG administration. Prostaglandins E and F may have a role in regulating ovum transport.
D000818:Animals; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D005187:Fallopian Tubes / Q000378:metabolism; D005260:Female; D007213:Indomethacin / Q000494:pharmacology; D010060:Ovulation / Q000187:drug effects; D010066:Ovum Transport / Q000187:drug effects; D011458:Prostaglandins E / Q000378:metabolism*; D011460:Prostaglandins F / Q000378:metabolism*; D011817:Rabbits; D013997:Time Factors
D006063:Chorionic Gonadotropin; D011458:Prostaglandins E; D011460:Prostaglandins F; D007213:Indomethacin