Anticonvulsant-induced osteomalacia.
Four cases of osteomalacia associated with the long term consumption of phenytoin (Dilantin) were admitted to a geriatric unit in a two-month period. No other cause for their disease was found. The diagnosis was made on biochemical data and no bone biopsy was obtained. Radiographic evidence was found in two cases only.
D000818:Animals; D002642:Chick Embryo; D004305:Dose-Response Relationship, Drug; D005260:Female; D050723:Fractures, Bone / Q000209:etiology; D006801:Humans; D010018:Osteomalacia / Q000139:chemically induced* / Q000150:complications; D010672:Phenytoin / Q000008:administration & dosage / Q000009:adverse effects*
D010672:Phenytoin