Control of the yeast Torulopsis glabrata in the stomachs of glucose fed lambs by oral dosing with nystatin and amphotericin "B".
In the absence of specific dietary lipids, large amounts of ethanol (ethyl alcohol) are produced from glucose in the stomachs of ruminant neonates by the resident yeast Torulopsis glabrata. Using new born lambs, oral dosing with the antifungal antibiotics Nystatin and Amphotericin "B" was shown in samples of stomach contents, to control the ethanol production entirely, and to suppress the yeast numbers partially but not permanently. Of 11 lambs receiving heavy and continous doses orally of the pure antibiotic powders, 7 died, of these 5 had developed adhesive peritonitis.
D000666:Amphotericin B / Q000009:adverse effects / Q000494:pharmacology*; D000818:Animals; D002175:Candida / Q000187:drug effects* / Q000378:metabolism; D000431:Ethanol / Q000096:biosynthesis; D005947:Glucose / Q000378:metabolism*; D009761:Nystatin / Q000009:adverse effects / Q000494:pharmacology*; D010538:Peritonitis / Q000139:chemically induced / Q000662:veterinary; D012756:Sheep / Q000382:microbiology*; D012757:Sheep Diseases / Q000139:chemically induced; D013279:Stomach, Ruminant / Q000382:microbiology*
D009761:Nystatin; D000431:Ethanol; D000666:Amphotericin B; D005947:Glucose