[Inhibitory effect of the calcium antagonist fendiline on digitalis glykosides induced contractions in the guinea pig terminal ileum (author's transl)].
The 10 mm muscle-strips from the guinea pig terminal ileum digitalis glycosides (0.4 microgram/ml beta-acetyl-digoxin or 0.5 microgram/ml k-strophanthin) induce contractions which are dose-dependently and reversibly prevented by the calcium antagonist N-(2-benzyl-ethyl)-N-(1-phenyl-ethyl)-amine hydrochloride (fendiline, Sensit) (0.01--1 microgram/ml). Therapeutic use of calcium antagonists for manifest symptoms of digitalis intoxication (diarrhoea, intestinal infarctions) is discussed as these symptoms may be caused by digitalis-induced increase of intracellular calcium ions.
D000818:Animals; D002118:Calcium / Q000037:antagonists & inhibitors*; D002301:Cardiac Glycosides / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D004077:Digoxin / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors / Q000494:pharmacology; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D010627:Phenethylamines / Q000494:pharmacology*; D013328:Strophanthins / Q000037:antagonists & inhibitors / Q000494:pharmacology; D013997:Time Factors
D002301:Cardiac Glycosides; D010627:Phenethylamines; D013328:Strophanthins; D004077:Digoxin; D002118:Calcium
Die Hemmwirkung des Ca++-Antagonisten Fendilin auf die durch Herz-Glykoside erzeugten Kontraktionen am terminalen Ileum des Meerschweinchens.