Monosodium glutamate admlinistration to the newborn reduces reproductive ability in female and male mice.
Monosodium glutamate (MSG) administered during the neonatal period (days 2 to 11) resulted in a sequence of events that were manifested in adulthood. Reproductive dysfunction was seen in both female and male animals. Females treated with MSG had fewer pregnancies and smaller litters, while males treated with MSG showed reduced fertility. The MSG-treated mice showed increased body weight and decreased pituitary, thyroid, ovary, or testis weights.
D000311:Adrenal Glands / Q000033:anatomy & histology; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001724:Birth Weight / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D005260:Female; D005298:Fertility / Q000187:drug effects*; D005971:Glutamates / Q000009:adverse effects*; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects*; D008098:Litter Size / Q000187:drug effects; D008297:Male; D051379:Mice; D009765:Obesity / Q000139:chemically induced; D009929:Organ Size / Q000187:drug effects; D010053:Ovary / Q000033:anatomy & histology; D010902:Pituitary Gland / Q000033:anatomy & histology; D011247:Pregnancy; D012970:Sodium Glutamate / Q000009:adverse effects*; D013737:Testis / Q000033:anatomy & histology; D013961:Thyroid Gland / Q000033:anatomy & histology
D005971:Glutamates; D012970:Sodium Glutamate