Interaction of DNA with a porphyrin ligand: evidence for intercalation.
The porphyrin photosensitizer, meso-Tetra (4-N-methylpyridyl) porphine tetraperchlorate binds to calf thymus DNA by intercalation and by external electrostatic association. This was concluded from the results of measruements involving Scatchard analysis, viscometry, thermal denaturation, and circular dichroism.
D000818:Animals; D002417:Cattle; D055598:Chemical Phenomena; D002621:Chemistry; D002942:Circular Dichroism; D004247:DNA; D007700:Kinetics; D009690:Nucleic Acid Conformation; D011166:Porphyrins; D013053:Spectrophotometry; D013950:Thymus Gland
D011166:Porphyrins; D004247:DNA