A morphologic study of intracerebral hemorrhage in a case of acute leukemia.
Morphologic studies have thus far failed to demonstrate the nature of the vessel involved in the brain hemorrhages of patients with acute leukemia. A detailed study of such hemorrhages was carried out in a patient with leukemic phase of mycosis fungoides. Plastic-embedded lesions showed that blast cells blocked the lumen of the capillary, leading to severe dilation and rupture of the vessel. The rheologic properties of blast cells in vessels of critical diameters seem to be an important factor in the pathogenesis of intracerebral hemorrhages.
D000208:Acute Disease; D001921:Brain / Q000473:pathology*; D002196:Capillaries / Q000473:pathology; D002543:Cerebral Hemorrhage / Q000209:etiology / Q000473:pathology*; D004906:Erythrocyte Count; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000150:complications / Q000473:pathology*