Synthesis of alpha-[7-methyl-9-methoxy-5-oxo-furo-[3,2-g] [1]-benzopyranoxy-4]-butyric and valeric acids and their aminoesters.
In the reaction of 4-desmethylkhelline with ethyl alpha-bromobutyrate or alpha-bromovalerate we obtained alpha-[7-methyl-9-methoxy-5-oxo-furo[3,2-g] [1] benzopyranoxy-4]-butyric 2 and valeric 3 acids and later their dialkylaminoethylesters as hydrochlorides (2b--2, 3b--3e). Compounds 2c, 2e, 2f (Table 1) and 3e (Table 2) show a weak hypotensic activity. Moreover compound 2f possesses an antriarrhythmic activity.
D000613:Aminobutyrates / Q000138:chemical synthesis; D000959:Antihypertensive Agents / Q000138:chemical synthesis*; D001578:Benzopyrans / Q000138:chemical synthesis*; D002087:Butyrates / Q000138:chemical synthesis*; D007666:Khellin / Q000031:analogs & derivatives*; D014631:Valerates / Q000138:chemical synthesis*
D000613:Aminobutyrates; D000959:Antihypertensive Agents; D001578:Benzopyrans; D002087:Butyrates; D014631:Valerates; D007666:Khellin