Development of factor VIII antibody in haemophilic monozygotic twins. European Study Group of Factor VIII Antibody.
The immunologic consequences of replacement therapy have been studied in 2 pairs of young haemophilic monozygotic twins. In both pairs one cotwin only developed a factor VIII specific antibody. This non-concordance illustrates the influence upon a specific immune response of non-genetic factors since the blood products, administered to each brother-pair, were not at all time identical nor were the regimens of transfusion therapy.
D000917:Antibody Formation; D001803:Blood Transfusion; D002648:Child; D002675:Child, Preschool; D004200:Diseases in Twins; D005169:Factor VIII / Q000276:immunology*; D005260:Female; D006467:Hemophilia A / Q000235:genetics / Q000276:immunology* / Q000628:therapy; D006801:Humans; D007223:Infant; D008297:Male; D011247:Pregnancy; D014430:Twins, Monozygotic
D005169:Factor VIII