title: Defects of the central nervous system in Finland: III. Disease and drugs in pregnancy.
abstract: The matched pair system of the Finnish Register of Congenital Malformations was used to search for association between defects of the central nervous system (CNS), and maternal diseases and/or drug consumption during pregnancy. The study material consisted of 710 cases with CNS defects and their controls. Significant associations were found for the following conditions: influenza, threatened abortion, depressive state, toxemia of pregnancy, diabetic mothers, and for the consumption of the following drugs: salicylates, pyrazolones/anilines, euphoristic analgesics, sympathomimetics, barbiturates, and cough medicines. 259 cases with polydactyly and their controls were also compared, with a view to demonstrating what biases might be introduced by the case-control method. After utilizing the possibilities of this design for examining the above mentioned significant associations, the factors to be seriously considered were reduced to the following ones: influenza, depressive state, toxemia of pregnancy, diabetic mothers and cough medicines.
mesh_terms: D000014:Abnormalities, Drug-Induced; D000015:Abnormalities, Multiple / Q000209:etiology; D000996:Antitussive Agents / Q000009:adverse effects; D002490:Central Nervous System / Q000002:abnormalities*; D000013:Congenital Abnormalities / Q000209:etiology*; D003863:Depression / Q000150:complications; D005260:Female; D005385:Fingers / Q000002:abnormalities; D005387:Finland; D006801:Humans; D007251:Influenza, Human / Q000150:complications; D011225:Pre-Eclampsia / Q000150:complications; D011247:Pregnancy; D011248:Pregnancy Complications; D011251:Pregnancy Complications, Infectious; D011261:Pregnancy Trimester, First; D011254:Pregnancy in Diabetics / Q000150:complications
chemical_list: D000996:Antitussive Agents