title: Piperoxane reduces the effects of clonidine on aggression in mice and on noradrenaline dependent hypermotility in rats.
abstract: Aggression in isolated male mice and hypermotility in rats produced by the noradrenaline releaser H 77/77 were studied after the s.c. administration of the alpha-adrenergic agonist clonidine and the alpha-antagonist piperoxane. Clonidine 0.005--0.5 mg/kg inhibited both behaviours while piperoxane showed a weak and short-lasting antiaggressive effect and no H 77/77 antagonism. Inactive doses of piperoxane reduced the inhibitory effects of clonidine. The results indicate that isolation-induced aggression in mice and H 77/77-induced hypermotility in rats are behavioural signs related to the availability of noradrenaline at the receptor.
mesh_terms: D000374:Aggression / Q000187:drug effects*; D000818:Animals; D003000:Clonidine / Q000494:pharmacology*; D004336:Drug Antagonism; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology*; D010880:Piperidines / Q000494:pharmacology*; D010883:Piperoxan / Q000494:pharmacology*; D051381:Rats; D014439:Tyramine / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D010880:Piperidines; D010883:Piperoxan; D003000:Clonidine; D009638:Norepinephrine; D014439:Tyramine