Prolactin: its role in the development of mammary tumours.
Experimentally, it has been found that the rate of DNA synthesis of normal mammary glands which is a limiting factor for mammary tumourigenesis is largely dependent upon the circulating level of prolactin. Based on these results, one of the roles of prolactin in the development of mammary tumours is hypothesized to create mammary gland conditions favourable for the action of carcinogens through its stimulation of the rate of mammary gland DNA synthesis, a measure of the frequency of mammary gland cell division.
D000818:Animals; D001943:Breast Neoplasms / Q000139:chemically induced; D004971:Estrus; D005260:Female; D006801:Humans; D008321:Mammary Glands, Animal / Q000187:drug effects; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced*; D051379:Mice; D011247:Pregnancy; D011388:Prolactin / Q000009:adverse effects* / Q000037:antagonists & inhibitors / Q000494:pharmacology; D051381:Rats
D011388:Prolactin