[The effect of sodium dantrolene on the detrusor urinae muscle of the bladder isolated from guinea pigs].
The effects of dantrolene sodium were evaluated in vitro using the guinea pig detrusor muscle preparation. Dantrolene reversibly decreased the strength of the responses of the detrusor to acetylcholine and histamine. The drug seems to depress the detrusor muscle of the bladder as it does others smooth muscles.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D003620:Dantrolene / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects* / Q000378:metabolism; D001743:Urinary Bladder / Q000187:drug effects / Q000378:metabolism
D006632:Histamine; D003620:Dantrolene; D000109:Acetylcholine
Effetti del dantrolene sodico sul muscolo detrusore di vescica urinaria isolata di cavia.