Chronic ECHO type 5 virus meningoencephalitis in X-linked hypogammaglobulinemia: treatment with immune plasma.
A patient with X-linked hypogammaglobulinemia developed chronic meningoencephalitis. ECHO virus type 5 was repeatedly cultured from cerebrospinal fluid (CSF). Infusions of high-titer, specific plasma resulted in clinical improvement, but failed to eradicate the virus. After more intensive plasma infusions, the virus could not be cultured from the CSF. The patient died 8 months after institution of intensive therapy. The cause of death was unknown. Autopsy showed persistence of perivascular and meningeal inflammation. Specific anti-ECHO-virus-5 plasma was shown to be more effective in lowering CSF ECHO-virus titers than was plasma without anti-ECHO-virus antibody.
D000293:Adolescent; D000361:Agammaglobulinemia / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D000914:Antibodies, Viral / Q000008:administration & dosage; D001921:Brain / Q000473:pathology; D004457:Echovirus Infections / Q000276:immunology* / Q000473:pathology; D029822:Enterovirus B, Human / Q000276:immunology; D006801:Humans; D007116:Immunization, Passive; D008297:Male; D008590:Meningoencephalitis / Q000000981:diagnostic imaging / Q000276:immunology* / Q000473:pathology; D012729:Sex Chromosome Aberrations / Q000276:immunology; D014057:Tomography, X-Ray Computed
D000914:Antibodies, Viral