Impairment of tracheal ring ciliary activity by halothane.
The effects of varying concentrations of halothane on tracheal ciliary activity were studied using a ferret tracheal organ culture technique. Using 1% and 2% halothane produced no impairment of ciliary activity, while 3% halothane caused some ciliostasis; 4% and 5% halothane produced rapid cessation of ciliary activity. Recovery was prompt and complete after exposure to 4% halothane for as long as 3 days, but after 4 days of exposure recovery was incomplete and after a week of exposure death of ciliary cells occurred.
D000769:Anesthesia, Inhalation; D000818:Animals; D002335:Carnivora / Q000033:anatomy & histology*; D002923:Cilia / Q000187:drug effects*; D005289:Ferrets / Q000033:anatomy & histology*; D006221:Halothane / Q000494:pharmacology*; D009924:Organ Culture Techniques / Q000379:methods; D014132:Trachea / Q000648:ultrastructure*
D006221:Halothane