The effects of lithium on phenylethylamine behavior in rats are counteracted by monoamine oxidase A and B inhibitors.
Rats given a subcutaneous injection of beta-phenylethyl-amine (PEA) (30 or 60 mg/kg) showed stereotyped behavior and autonomic effects which were suppressed by LiCl. Inhibition of Type A MAO by clorgyline or Lilly 51641 (2 or 8 mg/kg) or of Type B MAO by l-deprenyl (2 or 8 mg/kg) counteracted the suppressant effects of LiCl on PEA-behavior. The findings suggest that both Type A MAO and Type B MAO play a role in the effects of LiCl on PEA-behavior.
D000818:Animals; D001519:Behavior / Q000187:drug effects*; D006801:Humans; D008094:Lithium / Q000037:antagonists & inhibitors* / Q000097:blood / Q000494:pharmacology; D008297:Male; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D010627:Phenethylamines / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects*; D013997:Time Factors
D008996:Monoamine Oxidase Inhibitors; D010627:Phenethylamines; D008094:Lithium