Histamine H1- and H2-receptor-mediated gastric microcirculatory effects in the aetiology of stress ulceration in the rat stomach.
Stress produced severe mucosal ulcers, increased mucosal microcirculation and lowered mast cell counts in the glandular wall of rat stomachs. Mepyramine i.m. or metiamide i.p. effectively prevented both ulceration and microcirculatory changes but not stress-reduced mast cell counts.
D000631:Aminopyridines / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005753:Gastric Mucosa / Q000098:blood supply* / Q000166:cytology; D006801:Humans; D008297:Male; D008407:Mast Cells / Q000187:drug effects; D008785:Metiamide / Q000494:pharmacology*; D008833:Microcirculation / Q000187:drug effects; D011738:Pyrilamine / Q000494:pharmacology*; D051381:Rats; D011968:Receptors, Histamine / Q000502:physiology*; D013276:Stomach Ulcer / Q000209:etiology* / Q000517:prevention & control; D013315:Stress, Psychological / Q000150:complications*; D013890:Thiourea / Q000031:analogs & derivatives*
D000631:Aminopyridines; D011968:Receptors, Histamine; D008785:Metiamide; D013890:Thiourea; D011738:Pyrilamine