The effect of high animal protein intake on the risk of calcium stone-formation in the urinary tract.
1. Studies were carried out on six normal male subjects to determine the short-term effect of increasing the dietary consumption of animal protein on the urinary risk factors for stone-formation, namely, volume, pH, calcium oxalate, uric acid and glycosaminoglycans. 2. An increase of 34 g/day of animal protein in the diet significantly increased urinary calcium (23%) and oxalate (24%). Total urinary nitrogen increased by an average of 368 mmol/day. The accompanying increase in dietary purine (11 mmol of purine nitrogen/day) caused a 48% increase in the excretion of uric acid. 3. The overall relative probability of forming stones, calculated from a combination of the risk factors, was markedly increased (250%) throughout the period of high animal protein ingestion.
D000328:Adult; D000828:Animal Population Groups; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D004044:Dietary Proteins / Q000378:metabolism*; D006801:Humans; D008297:Male; D009584:Nitrogen / Q000652:urine; D011336:Probability; D012306:Risk; D014545:Urinary Calculi / Q000209:etiology*
D004044:Dietary Proteins; D009584:Nitrogen; D002118:Calcium