Acute effect of ascorbic acid on fibrinolytic activity.
The acute effect of 1 g oral ascorbic acid on serum fibrinolytic activity was studied in 40 adult males. In Group I (healthy adults) administration of ascorbic acid raised the serum level by about 71%, while the fibrinolytic activity increased to a peak of 137% at 6 h. In patients with CAD (Group II) an essentially similar increase in FA was observed. In Group III, simultaneous administration of ascorbic acid with 100 g fat effectively prevented a fall in fibrinolytic activity and actually raised it by 64% above the fasting level.
D000328:Adult; D001205:Ascorbic Acid / Q000097:blood / Q000494:pharmacology*; D002940:Circadian Rhythm; D003327:Coronary Disease / Q000097:blood; D005223:Fats / Q000008:administration & dosage; D005342:Fibrinolysis / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged
D005223:Fats; D001205:Ascorbic Acid