A possible relationship between high-extraction cereal and rickets and osteomalacia.
The evidence of the present study suggests a strong and possibly causal relationship between high-extraction cereal and rickets and osteomalacia. It seems likely that this occurs when vitamin-D status is border-line. The rachitogenic component of high-extraction cereal remains to be identified; dietary phytate now seems unlikely and phytate-derived polyphosphate esters or dietary phosphorus may be incriminated. The present study strongly indicates that Mellanby's original suggestion of an "anti-calcifying substance" in high-extraction cereal remains valid.
D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D044466:Asian People; D002648:Child; D004032:Diet / Q000009:adverse effects*; D005433:Flour / Q000009:adverse effects; D006801:Humans; D010018:Osteomalacia / Q000209:etiology*; D010710:Phosphates / Q000009:adverse effects; D010833:Phytic Acid / Q000009:adverse effects; D012279:Rickets / Q000209:etiology*; D012621:Seasons; D013472:Sunlight; D014807:Vitamin D / Q000378:metabolism
D010710:Phosphates; D014807:Vitamin D; D010833:Phytic Acid; D000469:Alkaline Phosphatase