Maternal age and the incidence of aneuploidy in first-cleavage mouse embryos.
Eggs obtained from young virgin and aged parous female mice were fertilized in vitro to compare the incidence of aneuploidy in the resulting first-cleavage embryos. There was a significantly higher incidence of aneuploidy in the aged group (7.5% versus 3.3%) and this was due solely to a higher proportion of trisomic female chromosome complements; there was no difference in the incidence of monosomics. These results thus suggest that non-disjunction occurs more frequently in eggs from older females, leading to the production of aneuploid embryos.
D000782:Aneuploidy; D000818:Animals; D002875:Chromosomes / Q000648:ultrastructure; D004622:Embryo, Mammalian / Q000648:ultrastructure*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D008423:Maternal Age; D051379:Mice; D011247:Pregnancy