Effect of 2-bromo-alpha-ergocryptine (CB-154) on estrogen induced growth of the rat prostate.
Castrate male Sprague-Dawley rats were treated with either testosterone; testosterone and estradiol; testosterone, estradiol and 2-Bromo-alpha-Ergocryptine (CB-154), an inhibitor of prolactin secretion; or testosterone and CB-154. Estradiol potentiated testosterone-induced growth of the dorsal, lateral, and ventral prostate and this effect was not counteracted by CB-154. Estradiol only induced hypertrophy of the dorsal and ventral prostate, however, hyperplastic changes occurred in the lateral prostate.
D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology*; D004357:Drug Synergism; D004958:Estradiol / Q000494:pharmacology*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011388:Prolactin / Q000037:antagonists & inhibitors; D011467:Prostate / Q000187:drug effects* / Q000254:growth & development / Q000502:physiology; D051381:Rats; D013739:Testosterone / Q000494:pharmacology
D001971:Bromocriptine; D013739:Testosterone; D004958:Estradiol; D011388:Prolactin