title: The relationship of sex steroids to uric acid levels in plasma and urine.
abstract: The effect of endogenous and exogenously administered oestrogens, androgens and progesterone on plasma and urinary uric acid and uric acid clearance was studied in a total of 65 healthy volunteers, including normal menstruating and post-menopausal women, girls with primary amenorrhoea and adult male subjects. A serial study throughout a full cycle in 3 women showed an inverse relationship between plasma uric and synthetic oestrogens produced a fall in plasma uric acid concentration through a uricosuric effect in most subjects of both sexes. Testosterone propionate caused a definite increase in plasma uric acid levels in post-menopausal women while endogenous testosterone changes due to Leydig cell stimulation produced no definite effect in male subjects. Administration of a progesterone preparation produced an effect similar to that of oestrogens in post-menopausal women. The evidence presented here supports ithe view that sex steroids play a significant part in uric acid regulation in biological fluids of both sexes.
mesh_terms: D000293:Adolescent; D000328:Adult; D000568:Amenorrhea / Q000378:metabolism; D000728:Androgens / Q000494:pharmacology; D004967:Estrogens / Q000494:pharmacology; D005260:Female; D012739:Gonadal Steroid Hormones / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008593:Menopause; D008598:Menstruation; D008875:Middle Aged; D011374:Progesterone / Q000494:pharmacology; D014527:Uric Acid / Q000097:blood / Q000378:metabolism* / Q000652:urine
chemical_list: D000728:Androgens; D004967:Estrogens; D012739:Gonadal Steroid Hormones; D014527:Uric Acid; D011374:Progesterone