[Test of combination of the agents coumarin and troxerutin for embryotoxic and teratogenic side-effects in Göttingen miniature pigs (author's transl)].
Göttingen miniature pigs were used to test a combination of the active principles coumarin and troxerutin (Venalot) for teratogenic and embryotoxiic side-effects. The experimental group consisted of 17 mother pigs with 95 fetuses, the control group of 6 untreated sows with 45 fetuses. The combination of coumarin and troxerutin was administered orally at a level of the 100-fold therapeutic dose (i.e. 25 mg coumarin + 150 mg troxertutin/kg/day) from day 6 to day 30 of gestation. The pathological and histological examinations of the uteri and fetuses revealed no indications of any embryotoxic or teratogenic damage caused by the tested combinations. Morphological and clinico-chemical investigations did also not result in any findings definitely attributable to the medication.
D000818:Animals; D003374:Coumarins / Q000008:administration & dosage / Q000009:adverse effects*; D004338:Drug Combinations; D005260:Female; D005313:Fetal Death / Q000139:chemically induced*; D006896:Hydroxyethylrutoside / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D012431:Rutin / Q000031:analogs & derivatives*; D013552:Swine; D013723:Teratogens
D003374:Coumarins; D004338:Drug Combinations; D006896:Hydroxyethylrutoside; D013723:Teratogens; D012431:Rutin
Uberprüfung einer Kombination der Wirkstoffe Cumarin und Troxerutin auf embryotoxische und teratogene Nebenwirkungen an Göttinger Miniaturschweinen