title: [Modification by drugs of cellular and humoral resistance mechanisms in animal experiments. I. In-vitro studies of peritoneal leukocytes and serums in rats].
abstract: 44 rats were fed p.o. with 3.1 ml/kg of Esberitox over a period of 5 days once daily, for increasing their non-specific resistance against injections. It could be shown that peritoneal leucocytes exhibited an increased phagocytosis of staphylococcus aureus. Besides the direct influence on the ingestion of this pathogenic microorganism, the leucocytes of the Esberitox group showed a stimulated uptake of oxygen when tested in vitro. The humoral defence seems also to be improved due to the elevated bactericidal activity of sera from Esberitox treated rats.
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D066298:In Vitro Techniques; D007962:Leukocytes / Q000276:immunology* / Q000378:metabolism; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects; D010537:Peritoneum / Q000276:immunology*; D010587:Phagocytosis / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D010936:Plant Extracts
vernacular_title: Uber die medikamentöse Beeinflussung zellulärer und humoraler Resistenzmechanismen im Tierversuch. I. In-vitro-Untersuchungen an Peritoneal-Leukozyten und Seren der Ratte.