Protective effect of creatinol O-phosphate (COP) on ventricular fibrillation and death induced by intravenous CaCl2 in mice.
The activity of N-methyl-N-(beta-hydroxyethyl)guanidine O-phosphate (creatinol O-phosphate, COP) on the acute toxicity of CaCl2 in mice was studied. The results obtained in the present investigation show that COP administered i.v. is able to antagonize, in a dose-dependent way, the lethal ventricular fibrillation provoked by CaCl2 in unanesthetized mice. Prenalamine and cinnarizine, two calcium antagonistic compounds, proved to be active in a way qualitatively similar to COP.
D000818:Animals; D002122:Calcium Chloride / Q000037:antagonists & inhibitors* / Q000633:toxicity; D002936:Cinnarizine / Q000494:pharmacology; D003401:Creatine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004562:Electrocardiography; D005260:Female; D008297:Male; D051379:Mice; D011299:Prenylamine / Q000494:pharmacology; D014693:Ventricular Fibrillation / Q000139:chemically induced / Q000517:prevention & control*
D002936:Cinnarizine; C100173:creatinol phosphate; D011299:Prenylamine; D002122:Calcium Chloride; D003401:Creatine