[Influence of extrapyramidal disorders induced by haloperidol on phenamine stereotypy and the effects of schizophrenic patients' serum (experimental study)].
Experiments on white mice demonstrated that the appearance of extrapyramidal disturbances depends upon the scheme of haloperidol administration. A long-term use of the preparation leads to development of habituation, while its cessation--to symptoms similar to withdrawal. The development of extrapyramidal disturbances does not increase the antagonism of haloperidol in relation to phenamine, but distinctly increases and prolongs the activizing action of the blood serum of schizophrenic patients on the behaviour of animals.
D000661:Amphetamine / Q000037:antagonists & inhibitors*; D000818:Animals; D001480:Basal Ganglia Diseases / Q000139:chemically induced*; D001519:Behavior; D001522:Behavior, Animal; D006220:Haloperidol; D006801:Humans; D007106:Immune Sera / Q000494:pharmacology; D051381:Rats; D012559:Schizophrenia / Q000097:blood*; D013239:Stereotyped Behavior
D007106:Immune Sera; D000661:Amphetamine; D006220:Haloperidol
Vliianie ékstrapirimidnykh narusheniĭ, vyzvannykh galoperidolom, na fenaminvovye stereotipii i éffekty syvorotke krovi bol'nykh shizofrenieĭ (éksperimental'noe issledovanie)