title: [Effect of antibiotics on the structure and function of the ovaries].
abstract: Streptomycin, penicillin, levomycetin, florimycin, cycloserin, erythromycin, sekazin, novobiocin, tetracyclines and neomycins had a stimulating effect on the sexual organs of the tests animals during the 1st decade of their administration. With long-term use some of the drugs induced dystrophic changes in the ovary. The signs of stimulation in the ovary were evident from increased activity of the oxidation-reduction enzymes in the inner membrane of the follicles and the interstitial cells of the stroma, as well as in an increase in the number of the maturating follicles. With long-term long use of erythromycin, sekasin or novobiocin, disappearance of the primordial follicles, an increase in the number of the atretic follicles and death of the ovocytes in the mature follicles were observed in the ovary.
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004971:Estrus / Q000187:drug effects; D005260:Female; D009929:Organ Size / Q000187:drug effects; D010053:Ovary / Q000187:drug effects* / Q000503:physiopathology; D011247:Pregnancy; D051381:Rats; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents
vernacular_title: O vliianii antibiotikov na strukturu i funktsiiu iaichnikov.