[Effect of destruction of midbrain raphe nuclei on the behavioral effects of dopaminergic substances and I-tryptophan].
In experiments on male albino rats, after electrolytic lesions of dorsal and median mesencephalic raphe nuclei, l-DOPA and apomorphine did not exert their stimulating effect on aggressiveness and emotional reactivity, seen in control false-operated animals. The inhibitory effect of haloperidol on emotional reactivity increased after raphectomy. The stereotype behaviour elicited by dopaminergic agents and their effects on exploratory motor activity were not changed by raphectomy. It is assumed that the effects of dopamino-potentiating agents on emotional reactivity are partly mediated by their influence on serotonergic system.
D000374:Aggression / Q000187:drug effects / Q000502:physiology; D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D001931:Brain Mapping; D001933:Brain Stem / Q000502:physiology*; D004644:Emotions / Q000187:drug effects / Q000502:physiology; D006220:Haloperidol / Q000494:pharmacology; D006801:Humans; D007980:Levodopa / Q000494:pharmacology*; D008297:Male; D008636:Mesencephalon / Q000502:physiology*; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D009526:Nialamide / Q000494:pharmacology; D009949:Orientation / Q000187:drug effects / Q000502:physiology; D011903:Raphe Nuclei / Q000502:physiology*; D051381:Rats; D012701:Serotonin / Q000502:physiology; D014364:Tryptophan / Q000494:pharmacology*
D012701:Serotonin; D007980:Levodopa; D014364:Tryptophan; D000661:Amphetamine; D006220:Haloperidol; D001058:Apomorphine; D009526:Nialamide
Vliianie razrusheniia iader shva srednego mozga na povedencheski éffekty dofaminergicheskikh veshchestv i I-triptofana.