Effects of t-AMCHA and EACA on the plasma kallikrein system.
Varied amounts of t-AMCHA or EACA added to non-contact fresh dog plasma generates kininogenase and TAME esterase activities. These phenomena may be abolished by prior addition of lima bean trypsin inhibitor. t-AMCHA or EACA had no effect on partially purified kallikrein, but had a significant inhibitory influence on plasma kininase. The generation of prekallikrein activator with t-AMCHA was ascertained by gel filtration on a Sephadex G-100 column. The blood kinin level increased about 50% one hr after administration of t-AMCHA. It is suggested from these results that t-AMCHA may initiate the true activation of the kallikrein system by activating the Hageman factor.
D000614:Aminocaproates / Q000494:pharmacology*; D015119:Aminocaproic Acid / Q000494:pharmacology*; D000818:Animals; D003509:Cyclohexanecarboxylic Acids / Q000494:pharmacology*; D004285:Dogs; D004950:Esterases / Q000032:analysis; D005174:Factor XII; D007610:Kallikreins / Q000032:analysis; D007705:Kinins / Q000097:blood; D014148:Tranexamic Acid / Q000494:pharmacology*
D000614:Aminocaproates; D003509:Cyclohexanecarboxylic Acids; D007705:Kinins; D014148:Tranexamic Acid; D005174:Factor XII; D004950:Esterases; D007610:Kallikreins; D015119:Aminocaproic Acid