[Concentrations of polyamines in maternal and umbilical-cord blood and in the amniotic fluid during normal human pregnancy and in feto-placental insufficiency].
Blood maternal polyamines during normal pregnancy exhibit an important augmentation around the 10th and the 34th-38th week, and a minor increase between the 20th-25th week of pregnancy. These peaks coincide with extremely important metabolic events in the feto-placental unit such as maximal growth rate in the placenta and fetus, respectively. The levels of polyamines measured from the 38th to 41th week in the blood of the umbilical cord are higher than in the blood of the mother. Putrescine, spermidine and spermine are not detectable when measured in the non-hydrolized amniotic fluid during normal pregnancy, instead a band with a lower Rf than spermine is present. In case of feto-placental insufficiency polyamine concentration in maternal blood are well below the normal values, from the 34th to 38th week of pregnancy. Such a behaviour appears for umbilical cord blood at the 38th and 39th week. Also the unknown polyamine of the amniotic fluid undergoes evident modification in feto-placental insufficiency. These results show that blood polyamines of the mother are probably of fetal origin, and that modified pattern of maternal polyamines may indicate an insufficient body growth of the fetus.
D000328:Adult; D000653:Amniotic Fluid / Q000032:analysis*; D005260:Female; D005312:Fetal Blood / Q000032:analysis*; D006801:Humans; D010922:Placenta Diseases / Q000097:blood*; D011073:Polyamines / Q000032:analysis / Q000097:blood*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood*
D011073:Polyamines
Concentrazioni di poliamine nel sangue materno e funicolare, a nel liquido amniotico durante la gravidanza umana normale e l'insufficienza feto-placentare.