Combination of two techniques: amniocentesis and nervous tissue explants. A pilot investigation.
Addition of serum derived from amniotic fluid cells (AFS) from Tay Sachs carrier to developing mouse cerebral cortex explants results in excessive accumulation of lipid in neuronal cytoplasm.
D000649:Amniocentesis / Q000379:methods; D000818:Animals; D002454:Cell Differentiation; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000166:cytology; D005260:Female; D006801:Humans; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods*; D013661:Tay-Sachs Disease / Q000175:diagnosis* / Q000503:physiopathology