[Epidemiology of hepatitis in Swiss hemophiliacs].
A total of 108 Swiss haemophiliacs (89 haemophilia A and 19 haemophilia B patients) were investigated for the presence of serological hepatitis B virusmarkers and for transaminase abnormalities; the patients were also evaluated regarding hepatitis history. 22% of the patients were found to have a history of acute clinical hepatitis. 82% showed signs of hepatitis B virus (or hepatitis Bs-antigen) exposure: 6% were shown to be hepatitis Bs-antigen carriers, hepatitis B2-antibodies were found in 71% and hepatitis Bc-antibodies in 72% of the patients. 39% of the haemophiliacs showed elevated transaminase activities; it must be assumed that a proportion of the patients of this group have asymptomatic chronic liver disease.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001798:Blood Proteins / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D005169:Factor VIII / Q000032:analysis; D006467:Hemophilia A / Q000150:complications*; D002836:Hemophilia B / Q000150:complications; D006509:Hepatitis B / Q000150:complications*; D006510:Hepatitis B Antibodies / Q000032:analysis; D006511:Hepatitis B Antigens / Q000032:analysis; D006801:Humans; D007223:Infant; D008875:Middle Aged; D013557:Switzerland; D000637:Transaminases / Q000378:metabolism; D065227:Transfusion Reaction
D001798:Blood Proteins; D006510:Hepatitis B Antibodies; D006511:Hepatitis B Antigens; D005169:Factor VIII; D000637:Transaminases
Hepatitisepidemiologie bei Schweizer Hämophilen.