title: [Role of serum fibrinogen penetrating the subarachnoid space in the pathogenesis of brief cerebral arteriospasm].
abstract: A mixture of fibrinogen (4 ml in a 1 per cent solutions) and thrombin (10 I.U.) were instilled into the cisterma magna of 18 dogs which led to the formation of a fibrin clot in the subarachnoid space. This fibrin clot produced a spasm of the large cerebral arteries, which resulted in a narrowing to 84.8 +/- 1.8 per cent of the initial value. The subsequent administration of 400 units of fibrinolysin into the cisterna magna led to the dissolution of the fibrin clot and the dilatation of the arterie to 116.3 +/- 2.5 per cent of the initial value. Experiments carried out in 15 cats showed that, after being brought in the subarachnoid space, the spasmogenic factor of the clot, which consisted of all blood components, passes through the arachnoid into the subdural space. The penetration of the spasmogenic factor from the blood clot located on the surface of the arachnoid from the subdural to the subrarachnoid space was not observed. The arachnoid proves to be a membrane which can only be passed in one direction by the spasmogenic blood factor.
mesh_terms: D000818:Animals; D002415:Cats; D004285:Dogs; D005260:Female; D005340:Fibrinogen / Q000633:toxicity*; D005342:Fibrinolysis; D007278:Injections, Spinal; D002546:Ischemic Attack, Transient / Q000134:cerebrospinal fluid / Q000209:etiology*; D008297:Male; D013346:Subarachnoid Space; D014662:Vasoconstrictor Agents / Q000134:cerebrospinal fluid*
chemical_list: D014662:Vasoconstrictor Agents; D005340:Fibrinogen
vernacular_title: Die Rolle des in den Subarachnoidalraum eingedrungenen Blutfibrinogens in der Pathogenese des kurzzeitigen Hirnarterienspasmus.