[Effect of neurotropic substances on sleep disorders caused by electrical stimulation of the hypothalamus in cats].
The total period of sleep decreased as a result of the REM-sleep deficite following rage reaction induced in cats by the electrical stimulation of the hypothalamus. Haloperidol (1, 2, 3 mg/kg), diazepam (0.5, 1 mg/kg), nitrazepam (1, 6 mg/kg), glutetymide (10, 30, 60 mg/kg), pentobarbital (5, 15, 30 mg/kg) failed to eliminate sleep disturbances induced by rage reaction; lithium hydroxybutyrate (100, 150 mg/kg), dimedrol (1.5, 6 mg/kg) and imipramine increased the total sleep time on account of the slow wave phase; sodium hydroxybutyrate (100 mg/kg) normalized the electrophysiological pattern of sleep, decreasing the REM-sleep latency and the number of waking cats, and increasing the total REM-sleep time and the number of REM-sleep episodes.
D000818:Animals; D002415:Cats; D004558:Electric Stimulation; D006801:Humans; D006993:Hypnotics and Sedatives; D007031:Hypothalamus; D008297:Male; D011619:Psychotropic Drugs / Q000627:therapeutic use*; D012894:Sleep Stages; D012893:Sleep Wake Disorders / Q000188:drug therapy* / Q000209:etiology; D013312:Stress, Physiological / Q000150:complications*
D006993:Hypnotics and Sedatives; D011619:Psychotropic Drugs
Vliianie neĭrotropnykh veshchestv na narushenie sna, obuslovlennoe élektricheskoĭ stimuliatsieĭ gipotalamusa u koshek.