Adrenocortical involution in rats during oestrus synchronisation with medroxyprogesterone.
Daily treatment of female rats with medroxyprogesterone acetate in aqueous suspension resulted in adrenocortical atrophy. The doses given were those used for oestrus synchronisation. Intramuscular injections of 2-0 mg medroxyprogesterone acetate were used to investigate the atrophic process. Adrenocortical involution was associated with extensive single cell deletion (apoptosis). It is suggested that theses changes were due to suppression of pituitary ACTH secretion. The cytological changes support the concept that single cell death plays an important role in organ remodelling. Biochemical determinations of DNA, RNA, protein and dry matter, and histological examination, did not reveal significant changes in the liver.
D000302:Adrenal Cortex / Q000187:drug effects* / Q000648:ultrastructure; D000311:Adrenal Glands / Q000187:drug effects*; D000818:Animals; D001284:Atrophy; D004973:Estrus Synchronization; D005260:Female; D008099:Liver / Q000187:drug effects; D008525:Medroxyprogesterone / Q000494:pharmacology*; D011247:Pregnancy; D051381:Rats
D008525:Medroxyprogesterone