title: Nifurtimox in the treatment of South American leishmaniasis.
abstract: A trial of Nifurtimox (Lampit) in 26 patients with mucocutaneous leishmaniasis is reported. 13 patients with cutaneous lesions and 13 patients with mucosal disease were treated with a daily oral divided dose of 10 mg/kg body-weight for 30 days. 46% of the cutaneous cases and only 15% of the mucosal cases apparently responded to this regimen during at least one year of follow up. The difficulties of assessing cure in this disease are briefly discussed. We consider that Nifurtimox remains an investigational drug. While possibly exhibiting some anti-leishmanial activity it cannot be recommended for routine use in either form of the disease.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005500:Follow-Up Studies; D006801:Humans; D007897:Leishmaniasis, Mucocutaneous / Q000175:diagnosis / Q000188:drug therapy*; D008875:Middle Aged; D009297:Nasal Mucosa; D009547:Nifurtimox / Q000009:adverse effects / Q000627:therapeutic use*; D009581:Nitrofurans / Q000627:therapeutic use*
chemical_list: D009581:Nitrofurans; D009547:Nifurtimox