title: [Effect of the influenza virus and its structural components on the animal immunocompetence system].
abstract: The authors studied the effect of the influenza virus A (PR8/34) and of its structural components on the immunological reactivity of mice. The enzyme of the external coat of the influenza virus--neuraminidase--possessed an immunodepressive action. Administration of neuraminidase led to the elimination of sialic acids from the surface of lymphocytes and to the reduction of their electrophoretic mobility. The mechanism of the immunodepressive action of neuraminidase is discussed.
mesh_terms: D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology* / Q000382:microbiology; D002642:Chick Embryo; D007165:Immunosuppression Therapy; D009980:Influenza A virus / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D009439:Neuraminidase / Q000276:immunology; D013499:Surface Properties; D013997:Time Factors
chemical_list: D009439:Neuraminidase
vernacular_title: Vliianie virusa grippa i ego strukturnykh komponentov na immunokompetentnuiu sistemu zhivotnykh.