Inherited combined deficiency of factor V and factor VIII: report of a case with normal factor VIII antigen and ristocetin-induced platelet aggregation.
A patient with inherited combined deficiency of factor V and factor VIII is reported, who demonstrated normal levels of factor VIII antigen and plasma cofactor for ristocetin-induced platelet aggregation. The relationship of this condition to classical hemophilia and von Willebrand's disease is discussed. The data presented suggest that multiple loci on at least 2 chromosomes are necessary for the normal expression of factor VIII activity.
D000328:Adult; D000941:Antigens; D005166:Factor V Deficiency / Q000150:complications* / Q000235:genetics; D005169:Factor VIII / Q000276:immunology*; D006467:Hemophilia A / Q000150:complications* / Q000235:genetics; D006801:Humans; D008297:Male; D010974:Platelet Aggregation; D012310:Ristocetin
D000941:Antigens; D012310:Ristocetin; D005169:Factor VIII