Termination of pseudopregnancy in rats by silastic-PVP-PGF2 alpha tube.
The efficacy of a one-end or both-end open Silastic-polyvinyl-pyrrolidone (Silastic-PVP) tube containing 600 microgram prostaglandin-F2 alpha (PGF2 alpha) and placed subcutaneously on day-6 of pseudopregnancy (PSP) in the induction of premature termination of PSP was compared. A both-end open Silastic-PVP-PGF2 alpha tube was more efficacious in inducing an early termination of PSP with a mean duration of 7.8 days. By contrast, PSP females receiving a one-end open Silastic-PVP-PGF2 alpha tube showed a mean duration of PSP of 9.9 days. The shortened duration of PSP in both these treatment groups was significantly different from the control value of 13.1 days. The significant drop in progesterone (delta 4P) but rise in 20 alpha-dihydroprogesterone (20 alpha-DHP) occurred 24 hr after treatment in PSP rats treated with both-end open Silastic-PVP-PGF2 alpha tube, whereas similar changes in delta 4P and 20 alpha-DHP took place 48-72 hr after the deposition of a one-end open Silastic-PVP PGF2 alpha tube. It is concluded than an initial larger amount of circulating PGF2 alpha is needed to induce an early premature termination of PSP. The exposure of corpus luteum to a more sustained but lower level of PGF2 alpha leads to a slower response.
D004092:20-alpha-Dihydroprogesterone / Q000097:blood; D000818:Animals; D004343:Drug Implants; D005260:Female; D008186:Luteolytic Agents; D011205:Povidone; D011374:Progesterone / Q000097:blood; D011460:Prostaglandins F / Q000008:administration & dosage / Q000494:pharmacology*; D011555:Pseudopregnancy / Q000187:drug effects*; D051381:Rats; D012826:Silicone Elastomers; D013997:Time Factors
D004343:Drug Implants; D008186:Luteolytic Agents; D011460:Prostaglandins F; D012826:Silicone Elastomers; D004092:20-alpha-Dihydroprogesterone; D011374:Progesterone; D011205:Povidone