[Effect of a benzopyrone compound on embryonic tissue and cell cultures (author's transl)].
Embryonic tissues and cells of the chicken were treated with a coumarin-rutin derivative preparation (Venalot). A total of 3000 cultures from embryonic epithelia, skeletal muscle tissue, and connective tissues were tested. At high dosages, never administered in the therapy, the preparation inhibited the cell proliferation strongly. With the diminution to therapeutical concentrations no longer inhibitory but stimulatory effects, viz. to mitosis, were revealed. High cell partition rates in the connective tissue (fibroblasts), in the epithelial cells and in the bony tissue of the embryonic os frontale (osteoblasts) are an indication of the mechanism of the known wound-healing accelerating action of the preparation. The effect of stimulating the proteolytic action in mesenchymal cells, observed on isolated peritoneal macrophages has been confirmed for the mesenchymal cell of the embryonic chicken.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D002642:Chick Embryo; D003374:Coumarins / Q000494:pharmacology*; D003470:Culture Media; D004338:Drug Combinations; D005347:Fibroblasts / Q000187:drug effects; D066298:In Vitro Techniques; D010006:Osteoblasts / Q000187:drug effects; D012431:Rutin / Q000494:pharmacology
D003374:Coumarins; D003470:Culture Media; D004338:Drug Combinations; D012431:Rutin
Die Wirkung eines Benzopyron-Präparates auf embryonale Gewebe und Zellen in Kultur.