[On the efficiency of new antiinflammatory agents. A comparative study (author's transl)].
In a comparative study new antiinflammatory agents, like sodium-(3-[(2,6-dichlorephenyl)-amino5-phenyl)-acetate (diclofenac); d,l-2-(3-phen0xy-phenyl) propionic acid (fenoprofen); 2-(3-benzoxyl-phenly-propionic acid (ketoprofen); cis-5-fluoro-2-methyl-1-(p-methylsulfinyl) benzylideryl-3-indenyl-acetic acid (MK 231, sulindac); 2-(6-methoxy-2-naphthyl)-propionic acid (naproxen/, showed nearly the same antiiflammatory effectiveness as 5-methoxy-2-methyl-1-(4-chlorobenzoyl)-indolyl-(3)-acetic acid (indometacin). In homogenates of inflamed rat paws an antiproteolytic activity of the new antiinflammatory agents was lacking.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001597:Benzylidene Compounds / Q000627:therapeutic use; D002351:Carrageenan; D004008:Diclofenac / Q000627:therapeutic use; D004487:Edema / Q000188:drug therapy* / Q000201:enzymology; D005279:Fenoprofen / Q000627:therapeutic use; D066298:In Vitro Techniques; D007192:Indenes / Q000627:therapeutic use; D007213:Indomethacin / Q000627:therapeutic use; D007660:Ketoprofen / Q000627:therapeutic use; D009288:Naproxen / Q000627:therapeutic use; D010653:Phenylbutazone / Q000627:therapeutic use; D011480:Protease Inhibitors; D051381:Rats
D000893:Anti-Inflammatory Agents; D001597:Benzylidene Compounds; D007192:Indenes; D011480:Protease Inhibitors; D004008:Diclofenac; D009288:Naproxen; D002351:Carrageenan; D007660:Ketoprofen; D010653:Phenylbutazone; D005279:Fenoprofen; D007213:Indomethacin
Zur Wirkungspotenz neuerer Antiphlogistika. Eine Verleichsuntersuchung