[Changes in the phagocytic activity of the peritoneal macrophages of white mice caused by alcoholic intoxication].
Observations made on white mice showed that doses of alcohol had a stimulating effect on the indices of macrophage acitivity (pagocytic number and phagocytic index), while longer administration of 40% ethyl alcohol solution (in doses of 0,1 ml for 21--30 days) suppressed the functional activity of macrophages. In vitro experiments in which macrophages were subjected to the action of ethyl alcohol showed that alcohol, depending on its concentration, had a direct effect on the cells of the microphage system.
D000435:Alcoholic Intoxication / Q000276:immunology*; D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000494:pharmacology; D006801:Humans; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology*; D051379:Mice; D010587:Phagocytosis / Q000187:drug effects*; D013997:Time Factors
D000431:Ethanol
Izmeneniia fagotsitarnoĭ aktivnosti peritoneal'nykh makrofagov belykh mysheĭ, vyzvannye alkol'noĭ intoksikatsieĭ.