Effects of the antibiotic netropsin on mouse ascites tumour chromosomes in vitro.
The antibiotic netropsin was found to induce an increase of the aberration frequency of up to 10% and a decondensation and elongation of centromeric regions of the chromosomes in mouse ascites tumour cells cultivated in vitro.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000235:genetics / Q000648:ultrastructure; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects* / Q000648:ultrastructure; D006146:Guanidines / Q000494:pharmacology*; D007621:Karyotyping; D051379:Mice; D009429:Netropsin / Q000494:pharmacology*
D006146:Guanidines; D009429:Netropsin