Attenuating effect of fighting on shock-induced gastric ulceration and hypertension: hypothesis of inhibition by sensory feedback.
A behavioral-biochemical hypothesis is presented to explain the attenuating effect of fighting on electric-shock induced gastric ulceration and hypertension in rats. It is suggested that shock-induced gastric lesions and hypertension result from undampened oscillations in central cholinergic and adrenergic activity, respectively, and that the sensory input derived from fighting serves to reduce the amplitude of these oscillations via a process of inhibition. The hypothesis suggests that other forms of sensory input in addition to that supplied by fighting--whether self-generated or produced artificially by electrical or mechanical stimulators--would have an identical equilibrating effect on oscillations in neurotransmitter activity.
D000320:Adrenergic Fibers / Q000503:physiopathology; D000374:Aggression / Q000502:physiology*; D000818:Animals; D002799:Cholinergic Fibers / Q000503:physiopathology; D004597:Electroshock; D005246:Feedback; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000503:physiopathology*; D007103:Immobilization; D051381:Rats; D013276:Stomach Ulcer / Q000209:etiology / Q000503:physiopathology*; D013564:Sympathetic Nervous System / Q000503:physiopathology*