title: Paraben allergy.
abstract: A hydrocortisone preparation containing methylparaben and propylparaben provoked bronchospasm and pruritus when given intravenously to an asthmatic patient, whereas another hydrocortisone preparation without paraben preservative did not. Direct and passive transfer (Prausnitz-Küstner) skin tests for immediate hypersensitivity to parabens were positive. Parabens, frequently employed as bacteriostatic agents, are capable of producing immunologically mediated, immmediate systemic hypersensitivity reactions.
mesh_terms: D001249:Asthma / Q000188:drug therapy*; D001986:Bronchial Spasm / Q000139:chemically induced*; D002648:Child; D004342:Drug Hypersensitivity / Q000209:etiology*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000139:chemically induced*; D007114:Immunization; D008297:Male; D010226:Parabens / Q000009:adverse effects* / Q000276:immunology / Q000627:therapeutic use; D011537:Pruritus / Q000139:chemically induced*; D012882:Skin Tests / Q000379:methods
chemical_list: D010226:Parabens