The effect of two inhibitors of histidine decarboxylase on gastric secretion in the rat.
The effects of the hydrazino-analogue of histidine (HH) and DL-gamma-N(1,2,3,4-tetrahydroisoquinolyl)-alpha-hydrazino-butyric acid (AIS 48), two inhibitors of histidine decarboxylase, and atropine on gastric secretion stimulated by histamine and pentagastrin were studied in the perfused rat stomach. The results confirm that the mechanism of action of the physiological polypeptide is mediated, and that the inhibition of histidine decarboxylase can be useful means to control gastric secretion.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002262:Carboxy-Lyases / Q000037:antagonists & inhibitors*; D004347:Drug Interactions; D005750:Gastric Juice / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology; D006639:Histidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006640:Histidine Decarboxylase / Q000037:antagonists & inhibitors*; D006834:Hydrazines / Q000494:pharmacology*; D007546:Isoquinolines / Q000494:pharmacology*; D008297:Male; D010418:Pentagastrin / Q000494:pharmacology; D051381:Rats
D006834:Hydrazines; D007546:Isoquinolines; D006639:Histidine; D001285:Atropine; D006632:Histamine; D002262:Carboxy-Lyases; D006640:Histidine Decarboxylase; D010418:Pentagastrin