Clinical pharmacology of methicillin in neonates.
The pharmacokinetic properties of methicillin were investigated in 59 newborn infants. Concentrations of methicillin in serum were approximately 58 and 80 microng/ml at one hour after 25 and 50 mg/kg doses, respectively. The average serum half-life values ranged from one to three hours and were inversely correlated with birth weight and chronologic age. The half-life values, volumes of distribution, and plasma clearances of methicillin are shown in relationship to gestational age and chronologic age. A dosage of 25 mg/kg is recommended for therapy of most neonatal staphylococcal diseases; the frequency of administration is altered on the basis of birth weight and chronologic age.
D001724:Birth Weight; D005260:Female; D005865:Gestational Age; D006207:Half-Life; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007700:Kinetics; D008712:Methicillin / Q000097:blood / Q000494:pharmacology*; D011247:Pregnancy; D013211:Staphylococcus aureus / Q000187:drug effects
D008712:Methicillin