[Myocardial energy metabolic disorders in emotional-pain stress and the prevention of these disorders by using sodium gamma-oxybutyrate].
Marked disorders of energy metabolism in the heart muscle simultaneously with the development of ulcerous lesions of the stomach were revealed in animals which had suffered an emotional-pain stress (EPS). These disorders are displayed in the fact that two hours after EPS, the glycogen reserve in the animal's myocardium diminishes, resynthesis of glycogen and oxidation of the main substrates of the tricarboxylic acid cycle are inhibited, and malate dehydrogenase and possibly other dehydrogenase systems of the mitochondria are partly inactivated. Such decrease in the activity of the metabolic tracts is attended by depression of the force and rate of cardiac contractions revealed on inducing a high rate of contractions. The preliminary administration of sodium gammaoxybutyrate to a considerable extent prevents all the changes in the animal's myocardium occurring due to the effect of EPS.
D000818:Animals; D002952:Citric Acid Cycle / Q000187:drug effects; D004734:Energy Metabolism / Q000187:drug effects*; D004789:Enzyme Activation / Q000187:drug effects; D005260:Female; D006003:Glycogen / Q000378:metabolism; D006801:Humans; D006885:Hydroxybutyrates / Q000627:therapeutic use*; D009206:Myocardium / Q000378:metabolism*; D010084:Oxidation-Reduction; D010146:Pain / Q000378:metabolism*; D051381:Rats; D012978:Sodium Oxybate / Q000378:metabolism / Q000627:therapeutic use*; D013315:Stress, Psychological / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D006885:Hydroxybutyrates; D005680:gamma-Aminobutyric Acid; D012978:Sodium Oxybate; D006003:Glycogen
Narusheniia énergeticheskogo metabolizma miokarda pri émotsional'no-bolevom stresse i profilaktika étikh narusheniĭ s pomoshch'iu gamma-oksibutirata natriia.