A possible effect of vitamin D metabolities on cell adhesion.
The effect has been studied of the metabolites of vitamin D on the adhesion of 3T6 fibroblast cells and of pig aortic endothelial cells in culture. 1,25-dihydroxycholecalciferol (x10(-7)M) caused a decrease within 2 h in the adhesive qualities of the cells causing them to float free in the medium; the largest effect was seen with the endothelial cells. All the metabolites of vitamin D tested produced an effect including 25-hydroxyvitamin D which appeared to also have a major toxic effect on the endothelial cells.
D000818:Animals; D001011:Aorta; D002448:Cell Adhesion / Q000187:drug effects*; D002478:Cells, Cultured; D055598:Chemical Phenomena; D002621:Chemistry; D004100:Dihydroxycholecalciferols / Q000494:pharmacology*; D004727:Endothelium; D005347:Fibroblasts; D006887:Hydroxycholecalciferols / Q000494:pharmacology*; D051379:Mice; D013552:Swine
D004100:Dihydroxycholecalciferols; D006887:Hydroxycholecalciferols