Effects of neonatal lead exposure on apomorphine-induced aggression and stereotypy in the rat.
Rats were exposed to lead via the maternal milk. At 90 days of age, lead-exposed pairs and control pairs were tested for aggression induced by 5.0 mg/kg apomorphine. The large increase in aggression in response to apomorphine seen in controls was markedly attenuated in lead-treated subjects. In contrast, apomorphine-induced stereotypy was not affected. These results provide a further demonstration of persistent behavioral abnormalities resulting from early exposure to lead at levels which do not affect weight gain or mortality.
D000374:Aggression / Q000187:drug effects*; D000818:Animals; D000831:Animals, Newborn; D001058:Apomorphine / Q000494:pharmacology*; D001519:Behavior / Q000187:drug effects*; D005260:Female; D006128:Growth / Q000187:drug effects; D006801:Humans; D007774:Lactation; D007854:Lead / Q000494:pharmacology*; D008297:Male; D008892:Milk; D011247:Pregnancy; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects*
D007854:Lead; D001058:Apomorphine