[The fetal hydantoin syndrome (author's transl)].
Two siblings have various congenital malformations due to the teratogenic effect of anticonvulsant drugs. Their mother has a 14-year history of continuous anticonvulsant medication. The malformations noted in the older girl are less and in the 8 years younger sister more extensively developed as well as in the fetal hydantoin syndrome. The causes of different severity of the fetal hydantoin syndrome in two sisters are discussed.
D000014:Abnormalities, Drug-Induced / Q000517:prevention & control; D000015:Abnormalities, Multiple / Q000139:chemically induced; D000293:Adolescent; D002648:Child; D004827:Epilepsy / Q000188:drug therapy; D005260:Female; D005385:Fingers / Q000002:abnormalities; D005532:Foot Deformities, Congenital; D006618:Hip Dislocation, Congenital / Q000139:chemically induced; D006801:Humans; D006827:Hydantoins / Q000009:adverse effects* / Q000627:therapeutic use; D006972:Hypertelorism / Q000139:chemically induced; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy; D011295:Prenatal Care; D013577:Syndrome
D006827:Hydantoins
Das embryopathische Hydantoin-Syndrom.