title: The biochemistry of depression.
abstract: The author outlines the hypothesis of the role of amines in depression. Postulating that depression involves a derangement of amine metabolism in which a deficit of amine activity occurs in certain areas of the brain which in turn results in altered transmission, the theory proposes that certain antidepressant drugs effect an elevation of brain amines restoring normal transmission and relieving the depression.
mesh_terms: D000928:Antidepressive Agents / Q000494:pharmacology*; D001679:Biogenic Amines / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D003863:Depression / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D006801:Humans; D008376:Maprotiline / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism
chemical_list: D000928:Antidepressive Agents; D001679:Biogenic Amines; D008376:Maprotiline; D012701:Serotonin; D004298:Dopamine; D009638:Norepinephrine