title: [Effect of BCNU on the kinetics of the primary immune response in mice].
abstract: It was shown in experiments on mice administered the alkylating agent BCNU (1,3-bis/2-chlorethyl/-I-nitrosourea) at a dose of 20 mg/kg 48 or 72 hours following immunization wtih sheep red cells that kinetics of producing antibody-forming cells assumes a wave-like pattern with a sharp alternation of rises and falls in the number of antibody inducers. Analysis of the data obtained allowed a conclusion that BCNU does not affect the recruitment -- transformation of the precursor cells to antibody-forming cells.
mesh_terms: D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects; D000937:Antigen-Antibody Reactions / Q000187:drug effects*; D002330:Carmustine / Q000276:immunology*; D005260:Female; D007114:Immunization; D007121:Immunocompetence / Q000187:drug effects; D007700:Kinetics; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D013997:Time Factors
chemical_list: D002330:Carmustine
vernacular_title: Vliianie BCNU na kinetiku pervichnogo immunnogo otveta u mysheĭ.