title: Diminished affinity for purine substrates as a basis for gout with mild deficiency of hypoxanthine-guanine phosphoribosyltransferase.
mesh_terms: D001375:Azaguanine / Q000494:pharmacology; D001665:Binding Sites; D004351:Drug Resistance; D004912:Erythrocytes / Q000201:enzymology; D005347:Fibroblasts / Q000201:enzymology; D006073:Gout / Q000201:enzymology*; D006147:Guanine / Q000378:metabolism*; D006579:Heterozygote; D006801:Humans; D007041:Hypoxanthine Phosphoribosyltransferase / Q000097:blood / Q000172:deficiency* / Q000378:metabolism; D007042:Hypoxanthines / Q000378:metabolism*; D007700:Kinetics; D007926:Lesch-Nyhan Syndrome / Q000201:enzymology; D010754:Phosphoribosyl Pyrophosphate / Q000378:metabolism
chemical_list: D007042:Hypoxanthines; D006147:Guanine; D010754:Phosphoribosyl Pyrophosphate; D007041:Hypoxanthine Phosphoribosyltransferase; D001375:Azaguanine