title: Effect of follicle-stimulating hormone and its antiserum on the activity of ornithine decarboxylase in the ovary of rat and hamster.
abstract: The ability of FSH to stimulate the activity of ornithine decarboxylase (ODC) in the ovary of the immature rat and cycling hamster has been examined using specific antisera to gonadotropins. The stimulatory effect of FSH on ODC activity in the ovary of the immature rat was abolished when LH antiserum was administered along with FSH, while similar administration of FSH antiserum had no effect on LH action in stimulating ODC activity, thereby demonstrating the specificity of the LH effect. During the estrus cycle of the hamster, ODC activity in the ovary could be detected only on the evening of proestrus, the maximal activity seen at 1700 h being associated with both the Graafian follicles and the rest of the ovarian tissue. Neutralization of the proestrous FSH surge had no effect on the activity of ODC in either of these tissues, while similar administration of LH antiserum at 1300 h of proestrus completely inhibited the ODC activity in both large follicles and the rest of the ovarian tissue. Thus, the surge of LH, but not of FSH, appears to be responsible for regulating the ODC activity in the ovary of the cycling hamster.
mesh_terms: D000818:Animals; D002262:Carboxy-Lyases / Q000378:metabolism*; D006224:Cricetinae; D004971:Estrus; D005260:Female; D005640:Follicle Stimulating Hormone / Q000276:immunology / Q000494:pharmacology*; D006064:Gonadotropins, Equine / Q000494:pharmacology; D007106:Immune Sera / Q000494:pharmacology; D007986:Luteinizing Hormone / Q000276:immunology / Q000494:pharmacology; D009955:Ornithine Decarboxylase / Q000378:metabolism*; D006080:Ovarian Follicle / Q000201:enzymology; D010053:Ovary / Q000187:drug effects / Q000201:enzymology*; D011247:Pregnancy; D051381:Rats
chemical_list: D006064:Gonadotropins, Equine; D007106:Immune Sera; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D002262:Carboxy-Lyases; D009955:Ornithine Decarboxylase