title: Medical treatment of the ductus arteriosus.
abstract: Prostaglandin administered by aortic infusion prevents ductus closure when this is desirable--as in term infants with pulmonary atresia or critical pulmonic stenosis--raising arterial oxygen tension to levels compatible with life. On the other hand, in prematures with persistent patency of the ductus, administering indomethacin inhibits prostaglandin sysnthesis, inducing closure, and can obviate surgery.
mesh_terms: D000818:Animals; D001241:Aspirin / Q000627:therapeutic use; D003326:Coronary Circulation; D004373:Ductus Arteriosus / Q000187:drug effects / Q000502:physiology*; D004374:Ductus Arteriosus, Patent / Q000188:drug therapy*; D005318:Fetal Heart / Q000502:physiology; D005557:Formaldehyde / Q000627:therapeutic use; D006330:Heart Defects, Congenital / Q000628:therapy*; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage / Q000627:therapeutic use*; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000628:therapy; D010100:Oxygen / Q000097:blood; D011448:Prostaglandin Antagonists / Q000627:therapeutic use; D011453:Prostaglandins / Q000502:physiology; D011458:Prostaglandins E / Q000008:administration & dosage / Q000627:therapeutic use*; D012756:Sheep
chemical_list: D011448:Prostaglandin Antagonists; D011453:Prostaglandins; D011458:Prostaglandins E; D005557:Formaldehyde; D001241:Aspirin; D010100:Oxygen; D007213:Indomethacin