Filter function of the guinea pig cochlea after degeneration of outer hair cells.
After kanamycin induced degeneration of outer hair cells from  guinea pigs the tuning properties of primary auditory nerve fibres are compared with those of normal untreated guinea pigs. The existence of fibres with no alteration of the tuning properties leads to the conclusion that there is no neural interaction between inner and outer hair cells needed to enhance the frequency selectivity.
D000818:Animals; D001306:Auditory Pathways / Q000187:drug effects; D001309:Auditory Threshold / Q000187:drug effects; D003051:Cochlea / Q000166:cytology / Q000187:drug effects*; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000166:cytology / Q000187:drug effects*; D007612:Kanamycin / Q000009:adverse effects; D008465:Mechanoreceptors / Q000187:drug effects*; D009410:Nerve Degeneration / Q000187:drug effects; D009412:Nerve Fibers / Q000187:drug effects
D007612:Kanamycin