Structural perturbations in the plasma membrane during concanavalin A endocytosis.
Endocytosis of Concanavalin A, triggered by its interaction with the surface of cells from a murine plasmocytoma line, is characterised by various steps which can be visualised by cytochemistry and freeze-fracturing. Plasma membrane internalisation is initiated by clustering of Concanavalin A receptors and by formation of intramembraneous particle necklaces, which were observed on fracture faces. Subsequent perturbation of the lipid bilayer precedes the fusion and formation of closed vesicles.
D000818:Animals; D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism / Q000648:ultrastructure*; D003208:Concanavalin A / Q000378:metabolism*; D004705:Endocytosis; D005614:Freeze Fracturing; D008563:Membrane Lipids / Q000378:metabolism; D051379:Mice; D010954:Plasmacytoma; D011952:Receptors, Concanavalin A
D008563:Membrane Lipids; D011952:Receptors, Concanavalin A; D003208:Concanavalin A