title: Effect of intravesical formalin on the urothelium.
abstract: In an experimental study, the urinary bladder of the rabbit was subjected to 10% formaldehyde instillation for periods ranging from 15 to 90 min. Varying degrees of cystitis, ranging from focal superficial to transmural necrotising cystitis, epithelial sloughs and intra-epithelial calcification may be seen. The depth of reaction was related approximately to the duration of exposure. Saline irrigation after instillation, contact time of 10 min and 1% formaldehyde seemed to reduce complications.
mesh_terms: D000818:Animals; D003556:Cystitis / Q000139:chemically induced* / Q000473:pathology; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D005557:Formaldehyde / Q000633:toxicity*; D008297:Male; D011817:Rabbits; D013997:Time Factors; D001743:Urinary Bladder / Q000187:drug effects / Q000473:pathology
chemical_list: D005557:Formaldehyde