Generic propoxyphene: need for clinical bioavailability evaluation.
Plasma level data on two investigational capsule formulations of propoxyphene with similar physicochemical parameters demonstrate that the formulations have different in vivo bioavailabilities. The potential bioavailability problems with water-soluble drugs and the lack of correlation of in vitro and in vivo parameters for equivalent drug formulations are discussed.
D000328:Adult; D001682:Biological Availability; D002214:Capsules; D011431:Dextropropoxyphene / Q000008:administration & dosage / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013810:Therapeutic Equivalency
D002214:Capsules; D011431:Dextropropoxyphene