Concentration of porcine proinsulin-like material in plasma of insulin-treated diabetics in relation to purity of insulin preparations.
Porcine proinsulin-like Material (P-PLM) was determined in plasma from 25 juvenile diabetics previously treated for more than six years with crystalline porcine insulin and again after 2--2 1/2 years subsequent treatment with highly purified porcine insulin. As P-PLM in insulin preparations was reduced from 7 mmol/mol insulin to 0.1 mmol/mol insulin, so plasma concentrations of P-PLM were reduced from mean 166 pmol/l (range 34--428) to mean 27 pmol/l (range 13--64) on the same insulin dose. During the same period, the insulin-binding capacity of plasma showed a decrease.
D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D007328:Insulin / Q000627:therapeutic use*; D007330:Insulin Antibodies / Q000032:analysis; D011384:Proinsulin / Q000097:blood*; D011863:Radioimmunoassay; D013552:Swine
D007328:Insulin; D007330:Insulin Antibodies; D011384:Proinsulin