[Hypoxic pulmonary vasoconstriction and angiotensin II blockade in calves (author's transl)].
The pulmonary vascular response to breathing low oxygen containing gas mixture was examined before and during Angiotensin II blockade in five open-chested newborn calves. Angiotensin II blockade was achieved by continuous infusion of Sar1-Ile5-Leu8-Angiotensin II (Saralasin), a competitive inhibitor of Angiotensin II. The hypoxic rise in pulmonary vascular resistance after blockade did not differ from that of control. It is concluded that Angiotensin II does not play a significant role in acute hypoxic pulmonary vasoconstriction in the calf.
D000804:Angiotensin II / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000818:Animals; D002417:Cattle; D000860:Hypoxia / Q000150:complications*; D008168:Lung / Q000098:blood supply; D008171:Lung Diseases / Q000209:etiology*; D011652:Pulmonary Circulation; D012504:Saralasin / Q000494:pharmacology*; D014661:Vasoconstriction
D000804:Angiotensin II; D012504:Saralasin
Vasocostrizione polmonare ipossica e blocco dell'angiotensina II nel vitello.