Benserazide induces migraine attacks. Irrelevance of concomitant hyperprolactinemia.
Migrainous women underwent acute administration of sulpiride (25 mg i.v.) and benserazide (125 mg per os), both drugs increasing prolactin secretion. A similar increase in prolactin levels was found following the administration of the two drugs. A typical migraine attack was observed only in the 4 women given benserazide. These data, though being preliminary, stress the scarce or irrelevant role of prolactin in the pathogenesis of the migraine attack.
D000328:Adult; D001545:Benserazide / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006834:Hydrazines / Q000009:adverse effects*; D008881:Migraine Disorders / Q000139:chemically induced*; D011388:Prolactin / Q000097:blood*; D013469:Sulpiride / Q000494:pharmacology
D006834:Hydrazines; D001545:Benserazide; D013469:Sulpiride; D011388:Prolactin