title: [Possibilities of earlier evidence of the lead load].
abstract: A total of 138 workers of a motorcar transportation plant were examined to show a degree of lead damage. The analysis of obtained results was conducted from the two points of view: 1) according to employment time in plant; 2) according to work groups. The following laboratory examinations were carried out: delta-aminolevulin acid and coproporphyrin urinary excretion; determination of serous transaminase of glutaminoxalacetic acid and glutamin and piruvic acid, leucinaminopeptidase, whole protein, albumin-globulin coefficient, protein fractions (albumin alpha 1-, alpha 2-, beta 1-, beta 2, gamma) as well as of dehydratase activity of delta-aminolevulin acid in erythrocytes. In conformity with literary data an increased urinary excretion of delta-aminolevulin acid and of coproporphyrin to a different degree, as well as a decrease of dehydratase content of delta-aminolevulin acid in erythrocytes were detected. In the authors' view attention is to be drawn to a minor or greater extent to proportional increase of leucinaminopeptidase content however, in all the age groups and all the professional categories. The results of present examinations are considered by authors an important and sensitive parameter to evidence of lead damage.
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000622:Aminolevulinic Acid / Q000652:urine; D001219:Aspartate Aminotransferases / Q000097:blood; D001798:Blood Proteins / Q000032:analysis; D003306:Coproporphyrins / Q000652:urine; D003937:Diagnosis, Differential; D004912:Erythrocytes / Q000201:enzymology; D006801:Humans; D007855:Lead Poisoning / Q000175:diagnosis*; D007931:Leucyl Aminopeptidase / Q000097:blood; D009790:Occupations; D000623:Porphobilinogen Synthase / Q000097:blood; D012709:Serum Albumin / Q000032:analysis; D012712:Serum Globulins / Q000032:analysis; D013997:Time Factors
chemical_list: D001798:Blood Proteins; D003306:Coproporphyrins; D012709:Serum Albumin; D012712:Serum Globulins; D000622:Aminolevulinic Acid; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D007931:Leucyl Aminopeptidase; D000623:Porphobilinogen Synthase
vernacular_title: Die Möglichkeiten des früheren Nachweises der Bleibelastung.