[Glycosaminoglycan metabolic disorders in periosteal and endosteal osteogenic cells in phenol poisoning].
The analysis of 35S sulphate incorporation into the growing bone structures in the experiment with 2-3 week guinea pigs subjected to long-term phenol intoxication made it possible to conclude that 35S sulphate assimilation by the osteogenic cells of periost and endost is less intensive in the treated animals, particularly in those receiving a large dose of phenol, (40 mg/kg) than in the control ones. This testifies to the reduction of the biosynthesis rates of sulphated glycosaminoglycans in the bone growth regions.
D000818:Animals; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism*; D006025:Glycosaminoglycans / Q000096:biosynthesis*; D006168:Guinea Pigs; D010006:Osteoblasts / Q000378:metabolism*; D010012:Osteogenesis / Q000187:drug effects*; D010521:Periosteum / Q000187:drug effects / Q000378:metabolism*; D010636:Phenols / Q000506:poisoning*; D013431:Sulfates / Q000378:metabolism
D006025:Glycosaminoglycans; D010636:Phenols; D013431:Sulfates
Narusheniia obmena glikozaminoglikanov v osteogennykh klethakh periosta i éndosta pri intoksikatsii fenolom.