title: Organic solvent soluble lipofuscin pigment in brain tissues of mice fed large amounts of polyunsaturated fats in presence and absence of various antioxidants.
abstract: The amount of lipid soluble fluorescent pigment is compared in brain tissues of mice fed a diet containing 10% safflower oil with and without a supplement of antioxidants as Vitamin E, Ascorbyl-Palmitate and Sodium-Selenite. Addition of 0.2 g/kg Vitamin E to the diet gives a high raise in the mortality. The addition of 0.2 g/kg Vitamin E and 0.5 g/kg Ascorbyl-Palmitate leads to higher values of extractable lipid soluble fluorescent pigment in mice brain tissues.
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D004041:Dietary Fats / Q000494:pharmacology*; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D005260:Female; D008062:Lipofuscin / Q000302:isolation & purification / Q000378:metabolism*; D051379:Mice; D010860:Pigments, Biological / Q000378:metabolism*; D012450:Safflower Oil; D012997:Solvents
chemical_list: D000975:Antioxidants; D004041:Dietary Fats; D005231:Fatty Acids, Unsaturated; D008062:Lipofuscin; D010860:Pigments, Biological; D012997:Solvents; D012450:Safflower Oil