Morphometric study of testicle alterations in rats submitted to hypervitaminosis A.
Testicle lesions and spermatogenetic activity in adult rats submitted to hypervitaminosis A were determined by quantitative studies of the germinal epithelium and of Leydig cells. Hypophysary levels of luteinizing hormone (LH) and relative weights of the adrenals were also determined, and the results were interpreted as being caused by the double mechanism of action (direct and indirect) of vitamin A.
D000311:Adrenal Glands / Q000187:drug effects; D000818:Animals; D005260:Female; D007985:Leydig Cells / Q000187:drug effects / Q000473:pathology; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D009929:Organ Size; D010902:Pituitary Gland / Q000378:metabolism; D051381:Rats; D013091:Spermatogenesis / Q000187:drug effects; D013094:Spermatozoa / Q000473:pathology; D013733:Testicular Diseases / Q000139:chemically induced* / Q000473:pathology; D013737:Testis / Q000187:drug effects* / Q000473:pathology; D014801:Vitamin A / Q000008:administration & dosage / Q000633:toxicity*
D014801:Vitamin A; D007986:Luteinizing Hormone