title: [Thrombocyte aggregation after vaginal hysterectomy with combined prevention of thromboembolism with macrodex 6% and sintrom].
abstract: The ADP- and collagen-induced thrombocyte aggregation has been investigated and statistically evaluated in 25 women. These patients had undergone vaginal hysterectomy and colporrhaphy due to descensus vaginae et uteri and received 500 ml Macrodex 6% during the operation and Sintrom from the 1st post-operative day as prophylactic treatment for early and late thromboembolism. After administration of dextran 60, the ability of the thrombocytes to aggregate was reduced by half, 2 hours post-operatively, independent of the concentration and type of agent added in the aggregation test, and remained at this level during the 1st post-operative day. The original values were once again attained on the 4th post-operative day. The speed and force of deaggregation showed reverse behaviour. There was no influence apparent due to age of the patient or phase of the cycle (proliferation, secretion and post-menopausal). By carrying out this combined prophylactic treatment for thromboembolism, satisfactory protection is provided in the dangerous phases during the operation and post-operatively.
mesh_terms: D000074:Acenocoumarol / Q000627:therapeutic use*; D000244:Adenosine Diphosphate; D000328:Adult; D003911:Dextrans / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008598:Menstruation; D010974:Platelet Aggregation / Q000187:drug effects*; D013923:Thromboembolism / Q000517:prevention & control*
chemical_list: D003911:Dextrans; D000244:Adenosine Diphosphate; D000074:Acenocoumarol
vernacular_title: Die Thrombozytenaggregation nach vaginaler Hysterektomie unter kombinierter Thromboembolieprophylaxe mit Macrodex 6% und Sintrom.