title: [Binding capacity of some drugs to plasma proteins of newborns in comparison with adults (author's transl)].
abstract: Comparative studies on binding capacity of some drugs to plasma proteins of newborns and adults were carried out. Plasma from the newborn and adult rabbits as well as human from 4 sources: a) from healthy adults, b) from cord blood, c) from 5 days old newborns, and 6 month old infants were used for the experiments. For methodological reasons in the first part of our studies we have chosen: two sulfonamides - sulfamethazine and sulfamethoxasole, chlorpromazine and sodium salicylate. In the experiments two different techniques were used 1) equilibrium dialysis, 2) ultrafiltration. On the basis of the results obtained in animals as well as in human beings it was noted that the degree of drug binding to plasma proteins in newborns was different from that observed in adults, it may be higher or lower according to the drug used. The knowledge of this fact is of great importance, and should be taken into consideration in the calculation of proper dosage of various drugs in the newborns and infants.
mesh_terms: D000328:Adult; D000367:Age Factors; D000818:Animals; D002746:Chlorpromazine / Q000378:metabolism*; D005312:Fetal Blood; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D011485:Protein Binding; D011817:Rabbits; D012980:Sodium Salicylate / Q000378:metabolism*; D013418:Sulfamethazine / Q000378:metabolism; D013420:Sulfamethoxazole / Q000378:metabolism; D013449:Sulfonamides / Q000378:metabolism*
chemical_list: D013449:Sulfonamides; D013418:Sulfamethazine; D013420:Sulfamethoxazole; D002746:Chlorpromazine; D012980:Sodium Salicylate
vernacular_title: Bindungskapazität der Serumeiweisskörper von Neugeborenen und Erwachsenen für einige Arzneimittel.