Asplenia syndrome in one of mono-zygotic twins.
One of mono-zygotic twins who had the asplenia syndrome with severe cardiac malformations is described, the other twin being normal. This is the first documented case of situs ambiguus in mono-zygotic twins. The relationship of situs ambiguus to situs inversus, which has previously been described in a number of mono-zygotic twin pairs (some concordant and some discordant) is unclear.
D000015:Abnormalities, Multiple / Q000175:diagnosis; D005260:Female; D006321:Heart / Q000196:embryology; D006330:Heart Defects, Congenital / Q000175:diagnosis*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D011247:Pregnancy; D012857:Situs Inversus / Q000150:complications; D013154:Spleen / Q000002:abnormalities* / Q000196:embryology; D014427:Twins; D014430:Twins, Monozygotic; D014684:Venae Cavae / Q000002:abnormalities