[Differential inhibition of synthesis and methylation of DNA fragments by hydroxyurea in L5178Y lymphoblasts in vitro].
In cultures of mouse L5178Y lymphoblasts treated with low concentrations of hydroxyurea during the logarithmic phase of growth differential inhibition of synthesis and methylation of various DNA fragments was observed. Some evidence is presented that the effect may be due to different sensitivity of cells to the action of hydroxyurea at various times of the S-phase.
D000818:Animals; D002460:Cell Line; D004273:DNA, Neoplasm / Q000096:biosynthesis* / Q000097:blood; D006918:Hydroxyurea / Q000494:pharmacology*; D007942:Leukemia, Experimental / Q000378:metabolism*; D008214:Lymphocytes / Q000187:drug effects; D008745:Methylation
D004273:DNA, Neoplasm; D006918:Hydroxyurea
Róznicowe hamowanie syntezy i metylacji fragmentów dna przez hydroksymocznik w limfoblastach L5178Y in vitro.