title: [Therapy of a refractory idiopathic thrombocytopenic purpura by vinblastine-loaded thrombocytes (author's transl)].
abstract: A 15-year-old patient with ITP which was refractory to corticosteroids, splenectomy, and immunosuppressive therapy with vincristine was twice treated with platelets loaded with vinblastine. Five days after the application of the platelets vinblastine complex the platelets began to rise up to 600 X 10(9)/l. The remission has lasted until now for more than 15 weeks. The therapy showed no major side effects except for a transient granulocytopenia.
mesh_terms: D000293:Adolescent; D001792:Blood Platelets; D006801:Humans; D008297:Male; D011696:Purpura, Thrombocytopenic / Q000188:drug therapy*; D014747:Vinblastine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D014747:Vinblastine
vernacular_title: Therapie einer refraktären idiopathisch-thrombozytopenischen Purpura mit Vinblastin-beladenen Thrombozyten.