Retrograde amnesia in chicks and mice induced by 3,4-dehydro-DL-proline, a proline analog.
L-proline induces retroactive amnesia without causing brain seizures or isoelectric activity. 3,4-dehydro-DL-proline, a proline analog containing a double-bond in the 5-membered ring, has similar effects at a smaller dose. Three experiments describe the amnestic qualities of 3,4-dehydro-DL-proline in a chick memory paradigm, the retrograde quality of this amnesia, and its existence in a mammalian (mouse) preparation. Finally, EEG records show that chicks injected with amnestic doses of 3,4-dehydro-DL-proline do not exhibit seizure spiking or abnormal electrical activity.
D000647:Amnesia / Q000139:chemically induced*; D000648:Amnesia, Retrograde / Q000139:chemically induced*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D002645:Chickens; D004569:Electroencephalography; D006801:Humans; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D011392:Proline / Q000031:analogs & derivatives* / Q000494:pharmacology; D013997:Time Factors
D011392:Proline