Biochemical frontiers of fibrosis: concepts and perspectives.
The inhibition of Fibrotic lesion are classified into two: specific and nonspecific inhibition. The specific inhibition is based on the chemistry and metabolism of collagen, whereas the nonspecific inhibition is viewed from the point of the fibro-proliferative inflammation preceding fibroblasts activation. A brief account is given on existing as well as perspective methods to present a frame work for a concept on pharmacology of fibrosis.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D003094:Collagen / Q000378:metabolism*; D003095:Collagen Diseases / Q000188:drug therapy* / Q000378:metabolism; D005347:Fibroblasts / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000209:etiology; D008054:Lipid Peroxides / Q000378:metabolism; D011392:Proline / Q000031:analogs & derivatives
D000893:Anti-Inflammatory Agents; D008054:Lipid Peroxides; D003094:Collagen; D011392:Proline