title: X-chromosome inactivation during differentiation of female teratocarcinoma stem cells in vitro.
abstract: Evidence is presented that both X chromosomes are genetically active in clonal cultures of undifferentiated female mouse teratocarcinoma stem cells derived from a spontaneous ovarian tumour. As the cells differentiate in vitro one of the X chromosomes becomes inactivated.
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002999:Clone Cells; D005260:Female; D007621:Karyotyping; D051379:Mice; D012730:Sex Chromosomes; D013724:Teratoma; D014960:X Chromosome