title: Effect of melatonin on induction of ovulation in the light- induced constant estrous-anovulatory syndrome and possible role of the brain serotoninergic system.
abstract: Continuous light (CL) induces constant estrous anovulatory (CEA) syndrome and blockade of pineal gland activity. Chronic treatment with metatonin is able to overcome the anovulatory state in about 70% of CL-CEA rats, and the luteinizing effect of melatonin is significantly counteracted either by feeding the animals with a tryptophan-poor diet or by injecting methiothepin, a blocker of central serotoninergic receptors. It appears that melatonin elicits luteinization in CL-CEA rats through the brain serotoninergic system.
mesh_terms: D000818:Animals; D000858:Anovulation / Q000188:drug therapy*; D004971:Estrus / Q000187:drug effects / Q000528:radiation effects; D005260:Female; D008027:Light; D008550:Melatonin / Q000494:pharmacology* / Q000627:therapeutic use; D008719:Methiothepin / Q000494:pharmacology; D010060:Ovulation / Q000187:drug effects* / Q000528:radiation effects; D010870:Pineal Gland / Q000528:radiation effects; D011247:Pregnancy; D051381:Rats; D011985:Receptors, Serotonin / Q000187:drug effects*; D014364:Tryptophan / Q000172:deficiency
chemical_list: D011985:Receptors, Serotonin; D008719:Methiothepin; D014364:Tryptophan; D008550:Melatonin