Dose-response relationships in attenuation of puromycin-induced amnesia by neurohypophyseal peptides.
Intracerebral injections of puromycin one day after training of mice in a Y-maze cause amnesia when the animals are tested 7 days later. This amnesia was shown to be attenuated by various neurohypophyseal hormones, analogs and fragments, administered subcutaneously immediately after training. Dose-response relationships have been obtained for the attenuation of puromycin-induced amnesia in mice by selected neurohypophyseal peptides. All of the compounds tested reduce the amnesia in a dose-related way, suggesting that these peptides may interact with specific receptors to induce their central effect. Among the peptides studied the two most potent--i.e., those that cause substantial retention of memory at the lowest doses--are the neurohypophyseal hormone arginine vasopressin and Z-prolyl-leucyl-glycinamide (Z-MIF).
D000647:Amnesia / Q000139:chemically induced* / Q000188:drug therapy; D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D051379:Mice; D010455:Peptides / Q000494:pharmacology*; D010904:Pituitary Gland, Posterior; D011691:Puromycin / Q000494:pharmacology*; D011955:Receptors, Drug / Q000187:drug effects
D010455:Peptides; D011955:Receptors, Drug; D001127:Arginine Vasopressin; D011691:Puromycin