[Influence of pyridoxal-5'-phosphate on the responses of isolated coronary arteries to adrenaline, in the presense of pyrogallol].
The effect of PLP on the adrenaline-induced relaxation of coronary arteries was studied in vitro, after known inhibitor of COMT, Pyrogallol. Relaxation of response to adrenaline were increased by PLP. Pyrogallol potentiated responses of coronary strips to adrenaline and also reduced or abolished the enhancing effects of PLP. It is concluded that PLP enhances the response of coronary smooth muscle to adrenaline by inhibiting a enzymatic pathway for the inactivation of catecholamines.
D000818:Animals; D002417:Cattle; D003331:Coronary Vessels / Q000187:drug effects*; D004357:Drug Synergism; D004837:Epinephrine / Q000494:pharmacology*; D066298:In Vitro Techniques; D009130:Muscle, Smooth / Q000187:drug effects; D011732:Pyridoxal Phosphate / Q000494:pharmacology*; D011748:Pyrogallol / Q000494:pharmacology*
D011748:Pyrogallol; D011732:Pyridoxal Phosphate; D004837:Epinephrine
Influenza del piridossal-5'-fosfato sulle risposte di arterie coronarie isolate all'adrenalina, in presenza di pirogallolo.