Evaluation of the toxicologic and teratogenic potentials of sodium fluorescein in the rat.
Sodium fluorescein (10%) when injected intravenously (5 ml/kg) in pregnant albino rats crossed the placental barrier and appeared to be distributed throughout the fetus within 15 min. It was detectable in the fetus up to 4 h after injection but not beyond 24 h. A single intravenous administration of sodium fluorescein did not produce embryotoxic or teratogenic effects. Oral LD50 studies using sodium phenobarbital on rats which received sodium fluorescein during their fetal development showed no apparent effects of sodium fluorescein on their drug detoxification systems.
D000014:Abnormalities, Drug-Induced; D000818:Animals; D005260:Female; D005452:Fluoresceins / Q000633:toxicity*; D008098:Litter Size / Q000187:drug effects; D008431:Maternal-Fetal Exchange; D010634:Phenobarbital / Q000494:pharmacology; D011247:Pregnancy; D051381:Rats; D013997:Time Factors; D014018:Tissue Distribution
D005452:Fluoresceins; D010634:Phenobarbital