title: Influence of ethanol on thyroxine accumulation in the hypothalamus, pituitary gland and cerebrospinal fluid in the newborn rabbit.
abstract: The effect of ethanol on thyroxine (T4) accumulation in the hypothalamus (H), pituitary gland (P) and cerebrospinal fluid (CSF) has been investigated in 1-15-day-old rabbits. It has been found that H or CSF serum ratios decreased with age by about 2 in the course of 13 postnatal days. Stable T4 resulted in an increase of 125 I-T4 in H, P and CSF. Ethanol per se caused an increase in transfer and accumulation of radiothyroxine or made the changes after loading animals with carrier T4 more pronounced.
mesh_terms: D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism; D001812:Blood-Brain Barrier / Q000187:drug effects*; D000431:Ethanol / Q000494:pharmacology*; D007031:Hypothalamus / Q000378:metabolism*; D010902:Pituitary Gland / Q000378:metabolism*; D013974:Thyroxine / Q000134:cerebrospinal fluid / Q000378:metabolism*
chemical_list: D000431:Ethanol; D013974:Thyroxine