[Hepatic energy metabolism disorders in emotionally-painful stress and prevention of these disorders with sodium gamma-hydroxybutyrate].
Content and biosynthesis of glycogen in rat liver tissue as well as transition of 14C from main substrates of tricarboxylic acid cycle to CO2, examined in liver slices, were studied under conditions of stress caused by pain and emotion. The stress was accompanied by mobilization of the glycogen deposits; glycogen synthesis in liver tissue and oxidation of pyruvate, asparate succinate or alpha-ketoglutarate in tricarboxylic acid cycle were inhibited. At the same time, the stress was accompanied by ulcerous impairments of gastric mucosa. The phenomena observed appear to be due to increased activity of adrenergic and sympathoadrenal systems. Prior to the stress administration of sodium gamma-hydroxybutyrate, which activates the inhibitory GHB-ergic system of brain, prevented distinctly the impairments found.
D000818:Animals; D002952:Citric Acid Cycle; D005260:Female; D005943:Gluconeogenesis; D005971:Glutamates / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D006019:Glycolysis; D006801:Humans; D006885:Hydroxybutyrates / Q000627:therapeutic use*; D008099:Liver / Q000378:metabolism*; D010071:Oxaloacetates / Q000378:metabolism; D051381:Rats; D012978:Sodium Oxybate / Q000627:therapeutic use*; D013315:Stress, Psychological / Q000188:drug therapy* / Q000378:metabolism
D005971:Glutamates; D006885:Hydroxybutyrates; D010071:Oxaloacetates; D012978:Sodium Oxybate; D006003:Glycogen
Narusheniia énergeticheskogo metabolizma pecheni pri emotsional'no-bolevom stresse i preduprezhdenie étikh narusheniĭ gammaoksibutiratom natriia.