[Induced hypocalcaemia test using salmon calcitonin as a means for the evaluation of osteoclastic activity (author's transl)].
The authors measured the degree of hypocalcaemia (delta Ca S), hypophosphataemia and the fall in urinary hydroxyproline excretion induced by an intramuscular injection of 100 MRC U of synthetic salmon calcitonin (S.C.T.) during the 24 hours following the injection. In 15 control subjects, the fall in plasma calcium was slight ( - 2.1 +/- 0.9 mg/l) but significant. In bone diseases involving hyperosteoclastosis, the degree of hypocalcaemia was much greater: 10.6 +/- 1.1 mg/l in 24 cases of Paget's disease, - 9.0 +/- 1.6 mg/l in 5 cases of diffuse malignant disease of bone, - 8.0 +/- 1.4 mg/l in 6 cases of primary hyperparathyroidism and - 3.5 +/- 0.8 mg/l in 13 cases of algodystrophy of the limbs. In the subjects studied as a whole there was a significant linear relationship between the delta Ca S and the extent of the trabecular surfaces of osteoclastic resorption, but not between delta Ca S and total 24 hour urinary hydroxyproline excretion. The S.C.T. hypocalcaemia test would appear to be a simple means for the evaluation of osteoclastic activity within the skeleton, and thus to select those bone disorders which should respond to antiosteoclastic therapy (calcitonin, diphosphonates).
D000328:Adult; D000818:Animals; D001847:Bone Diseases / Q000175:diagnosis* / Q000188:drug therapy; D001859:Bone Neoplasms / Q000175:diagnosis; D002116:Calcitonin; D004164:Diphosphonates / Q000627:therapeutic use; D006801:Humans; D006909:Hydroxyproline / Q000652:urine; D006961:Hyperparathyroidism / Q000175:diagnosis; D006996:Hypocalcemia / Q000139:chemically induced; D008875:Middle Aged; D010001:Osteitis Deformans / Q000175:diagnosis; D010010:Osteoclasts; D010710:Phosphates / Q000097:blood; D012019:Reflex Sympathetic Dystrophy / Q000175:diagnosis; D012474:Salmon
D004164:Diphosphonates; D010710:Phosphates; D002116:Calcitonin; D006909:Hydroxyproline
Evaluation de l'activité ostéoclastique par le test d'hypocalcémie provoquée par la calcitonine de saumon.