Improvement in multiple sclerosis during prolonged induced hypothermia.
Moderate hypothermia (33 degrees C) was induced for 7 and 3 days, respectively, in two patients with multiple sclerosis. In both patients, striking improvement of clinical signs persisted throughout the period of cooling, indicating the potential for sustained reversal of the neurologic deficit. Hypothermia may aid management of severe acute exacerbations of multiple sclerosis.
D000208:Acute Disease; D000328:Adult; D001831:Body Temperature; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000628:therapy*; D009460:Neurologic Examination; D012075:Remission, Spontaneous; D013997:Time Factors