[Murine hematopoietic stem cells after acute and chronic administration of vincristine].
The effects of vincristine on bone marrow hemopoietic stem cells were studied in mice. After the administration of a single dose of the drug there is a sharp decline in the content of CFUs. When the drug is given in small, weekly doses for 16 weeks, after an initial drop, the stem cell content rises at a normal level where it remains, although with wide oscillations. On the whole the effects of vincristine on b.m. CFUs are comparable with that observed after vinblastine administration.
D000818:Animals; D001815:Bloodletting; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D051379:Mice; D014750:Vincristine / Q000008:administration & dosage / Q000494:pharmacology*
D014750:Vincristine
Cellule staminali emopoietiche murine dopo somministrazione acuta e cronica di vincristina.