[Decrease in the stress reaction and the ulcerative lesions of the stomach under the influence of gamma-hydroxybutyric acid].
The effect of preliminary Na gamma-hydroxybutyric acid (GHBA) injection on the activation of adrenergic and hypophyseal-adrenal systems during emotional-painful stress and ulcerous affection of the stomach after the stress cessation was studied in experiments on rats. It was established that the preliminary GHBA administration inhibits stimulation of stress causing systems and thereby prevents ulcerous affection of the stomach mucosa. It is suggested that the activation of GHBA-ergic inhibiting system, which accompanies the stress, is a natural mechanism of limitation of the stress reaction and prevention of the stress affections.
D000818:Animals; D018756:GABA Antagonists; D006801:Humans; D006885:Hydroxybutyrates / Q000494:pharmacology*; D010913:Pituitary-Adrenal System / Q000187:drug effects; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects; D013276:Stomach Ulcer / Q000517:prevention & control*; D013315:Stress, Psychological / Q000517:prevention & control*
D018756:GABA Antagonists; D006885:Hydroxybutyrates; D011941:Receptors, Adrenergic
Umen'shenie stressornoĭ reaktsii i iazvennykh porazheniĭ zheludka pod vliianiem GOMK.