Adrenergic innervation and adrenergic mechanisms. A study of the human urethra.
Adrenergic nerves studied by a histochemical method were uniformly distributed along the whole extent of the male and female urethra. Corresponding to the adrenergic innervation a preponderance of contraction-mediating alpha-adrenoceptors was found in vitro studying urethral strips and in vivo recording the urethral closure pressure profile (UCPP). Norephedrine significantly reduced incontinence and increased UCPP in stress-incontinent women.
D000320:Adrenergic Fibers / Q000166:cytology*; D000328:Adult; D000368:Aged; D001626:Bethanechol Compounds / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008856:Microscopy, Fluorescence; D008875:Middle Aged; D009130:Muscle, Smooth / Q000294:innervation; D010665:Phenylpropanolamine / Q000494:pharmacology / Q000627:therapeutic use; D011312:Pressure; D011941:Receptors, Adrenergic / Q000033:anatomy & histology / Q000502:physiology; D011950:Receptors, Cholinergic / Q000033:anatomy & histology / Q000502:physiology; D014521:Urethra / Q000294:innervation*; D001743:Urinary Bladder / Q000294:innervation; D014550:Urinary Incontinence, Stress / Q000188:drug therapy; D014563:Urodynamics
D001626:Bethanechol Compounds; D011941:Receptors, Adrenergic; D011950:Receptors, Cholinergic; D010665:Phenylpropanolamine