Hypothalamic self-stimulation under the chronic morphine treatment in the rat.
The influence of morphine on self-stimulation (SS) under chronic morphine administration (30 injections for 15 days) in increasing doses (from 20 to 20 mg/kg/injection) has been studied. Initial doses had a depressive effect varying in degree in different animals. Subsequent injections activated "reward" behavior. This activation is suggested as one of the neurophysiological mechanisms of morphine abuse and addiction.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004558:Electric Stimulation; D004567:Electrodes, Implanted; D006801:Humans; D007031:Hypothalamus / Q000502:physiology*; D008297:Male; D009020:Morphine / Q000008:administration & dosage / Q000494:pharmacology*; D009021:Morphine Dependence / Q000503:physiopathology; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D012653:Self Stimulation / Q000187:drug effects*; D013997:Time Factors
D009020:Morphine