title: [Content of dicarboxylic acids and GABA in normal suslik brain and under the effect of oxygen at higher pressure].
abstract: The content of glutamic, asparaginic and gamma-aminobutyric (GABA) acids in norm and under hyperoxia was determined in different cerebral areas of susliks living in places at different heights above sea level. In susliks at a height of 1700-2000 m above sea level the content of glutamate aspartate and GABA lowers significantly as compared to that in susliks at a height of 500-600 m above sea level. Under the effect of oxygen 6 at. ga at the 22nd minute on the average there occur convulsions in susliks living both in high mountains and middle mountains. Acute oxygen poisoning is not accompanied by noticeable shifts in the content of free dicarboxylic amino acids in the studied cerebral areas of middle-mountain susliks and is characterized only by an increase of the GABA content in the cerebellum. In high-mountain susliks the content of glutamate under these conditions increases in great cerebral hemispheres, while the asparate content lowers in cerebral hemispheres and cerebellum. In the latter the drop in the content of GABA is statistically significant.
mesh_terms: D000531:Altitude; D000613:Aminobutyrates / Q000378:metabolism*; D000818:Animals; D001274:Atmospheric Pressure; D001921:Brain / Q000378:metabolism*; D003998:Dicarboxylic Acids / Q000378:metabolism*; D010100:Oxygen; D012589:Sciuridae / Q000378:metabolism*; D014018:Tissue Distribution; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
chemical_list: D000613:Aminobutyrates; D003998:Dicarboxylic Acids; D005680:gamma-Aminobutyric Acid; D010100:Oxygen
vernacular_title: Soderzhanie dikarbonovykh aminokislot i gamk v golovnom mozge suslikov v norme i pri deĭstvii kisloroda pod pov'shennym davleniem.