[Role of distant lymphoid cell interactions for the development of in vitro antibody formation].
In order to clarify the nature of the recently described intercellular local interactions which were shown to inhibit the antibody-forming cells (AFC) proliferation in vitro, a possibility of realization of this effect at a distance was studied. It was shown that the population with a great number of cells could inhibit in vitro at a distance an increase of the AFC in the population of cells separated from the former by a millipore filter, impermeable for the cells. The results were the same with the use of polymethylmetacrylate film (5 to 10 micrometer in thickness) impermeable for proteins with a molecular weight of 150000 daltons (125I-IgG-antibodies) and some ions (51CrO4), but permeable for other substances with low molecular weight.
D000818:Animals; D000917:Antibody Formation; D000921:Antibody-Producing Cells / Q000276:immunology*; D002478:Cells, Cultured; D003602:Cytotoxicity, Immunologic; D008214:Lymphocytes / Q000276:immunology*; D008567:Membranes, Artificial; D051379:Mice; D008810:Mice, Inbred C57BL; D008851:Micropore Filters; D011109:Polymethacrylic Acids; D013154:Spleen / Q000166:cytology
D008567:Membranes, Artificial; D011109:Polymethacrylic Acids
Rol' distantnykh vzaimodeĭstviĭ limfoidnykh kletok dlia razvitiia antiteloobrazovaniia in vitro.