Pharmacological studies of o-chloro-alpha-[(tert.-butylamino)methyl]benzylalcohol hydrochloride (C-78), a new bronchodilator. III. Actions on the nervous systems and miscellaneous organs.
Pharmacological effects of o-chloro-alpha-[(tert.-butylamino)methyl]benzylalcohol hydrochloride (C-78) on the nervous systems and miscellaneous organs were studied. 1. Through a low dosage of C-78 had little influence on the central nervous system, a high dosage of C-78 had a little slow-waving effect on the spontaneous EEG in rabbits, inhibitory action of the convulsion caused by pentetrazol or electroshock in mice and anti-pyrogenic action in rabbits. C-78 also dose-dependently inhibited the increase of motility caused by amphetamine in mice. 2. Only high concentrations of C78 had a local anesthetic action on the cornea and the skin of the back in guinea pigs. 3. C-78 significantly increased non-esterified fatty acids (NEFA) and glucose contents of blood in rabbits, but these actions were inhibited by propranolol. Another, high dosage of C-78 had anti-ulcer and anti-inflammatory action. From the results of the previous experiments and this study, it was concluded that C-78 is a new beta 2-receptor stimulating drug where beta 2-receptor selectivity is greater than that of isoproterenol, salbutamol and clorprenaline.
D000700:Analgesics; D000779:Anesthetics, Local; D000818:Animals; D000893:Anti-Inflammatory Agents; D000897:Anti-Ulcer Agents; D000927:Anticonvulsants; D000932:Antiemetics; D001592:Benzyl Alcohols / Q000494:pharmacology*; D001593:Benzyl Compounds / Q000494:pharmacology*; D001773:Blood Cells / Q000187:drug effects; D001777:Blood Coagulation / Q000187:drug effects; D001786:Blood Glucose / Q000378:metabolism; D001831:Body Temperature / Q000187:drug effects; D001993:Bronchodilator Agents / Q000494:pharmacology*; D004231:Diuresis / Q000187:drug effects; D004285:Dogs; D004569:Electroencephalography; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009420:Nervous System / Q000187:drug effects*; D009469:Neuromuscular Junction / Q000187:drug effects; D004856:Postural Balance / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D012890:Sleep / Q000187:drug effects
D000700:Analgesics; D000779:Anesthetics, Local; D000893:Anti-Inflammatory Agents; D000897:Anti-Ulcer Agents; D000927:Anticonvulsants; D000932:Antiemetics; D001592:Benzyl Alcohols; D001593:Benzyl Compounds; D001786:Blood Glucose; D001993:Bronchodilator Agents; D005230:Fatty Acids, Nonesterified