[Biotransformation and pharmacokinetics of grandiflorenic acid [kauradien-9(11),16-oic acid-18]. 3rd communication (author's transl)].
Absorption, metabolism and excretion of 14C-GFA following i.v., i.p. and oral application are investigated in rats. After i.p. administration GFA is completely absorbed, after oral dosage about 83% are absorbed. GFA is excreted by 100% via bile and undergoes extensive enterohepatic circulation. After administration of 20 mg/kg 14C-GFA nearly all radioactivity is eliminated after 96 h, more than 80% via the faeces.
D000284:Administration, Oral; D000818:Animals; D001646:Bile / Q000378:metabolism; D001711:Biotransformation; D001944:Breath Tests; D002264:Carboxylic Acids / Q000008:administration & dosage / Q000378:metabolism / Q000652:urine; D004224:Diterpenes / Q000008:administration & dosage / Q000378:metabolism* / Q000652:urine; D005243:Feces / Q000032:analysis; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D051381:Rats; D013997:Time Factors
D002264:Carboxylic Acids; D004224:Diterpenes
Biotransformation und Pharmakokinetik von Grandiflorensäure [Kauradien-9(11),16-säure-18] 3. Mitteilung: Untersuchungen zur Pharmakokinetik an Ratten.