Chromosomal aberrations and morphological transformation in hamster embryonic cells treated with potassium dichromate in vitro.
The addition of K2Cr2O7, at concentrations ranging from 0.1 to 0.5 microng/ml, to hamster total embryonic cells for 24 h, resulted in consistent and drastic chromosomal aberrations including gaps, breaks and exchanges. The above effect, however, was reduced successfully by the addition of a reducing agent, Na2SO3. Among other chromium compounds examined, divalent and trivalent chromium salts were ineffective on chromosome morphology even at a concentration of 3.5 microng/ml as chromium, whereas a hexavalent compound, CrO3, was highly effective. K2Cr2O7 also enhanced the morphological transformation rate in a short-term colony assay, in whicy hamster embryonic cells (1x10(4) cells/60-mm dish) were treated and the morphology was observed 8 to 10 days after the treatment.
D000818:Animals; D002478:Cells, Cultured / Q000648:ultrastructure; D002840:Chromates / Q000633:toxicity*; D002857:Chromium / Q000633:toxicity; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects*; D006224:Cricetinae / Q000196:embryology; D010084:Oxidation-Reduction; D011192:Potassium Dichromate / Q000037:antagonists & inhibitors / Q000633:toxicity*; D013447:Sulfites / Q000494:pharmacology
D002840:Chromates; D013447:Sulfites; D002857:Chromium; D011192:Potassium Dichromate