title: [Characteristics of early autoimmune reaction in vaccinated and revaccinated animals].
abstract: Experiments were conducted on albino mongrel female mice weighing 18 to 22 g. Development of early autoimmune reaction in response to the primary administration of microbial antigens was revealed; its intensity and duration depended on the dose of the antigen. Injection of physiological saline of the same or greater volume led only to the short-lived increase in the count of the autoantibody synthesizing cells in the spleen tissue. In repeated contact with the given antigen, there was noted a marked intensification of the reaction to homologous antigen, and a depression--to heterologous one in 7 to 14 days. Reaction to the administration of physiological saline alone failed to alter.
mesh_terms: D000818:Animals; D000917:Antibody Formation; D000921:Antibody-Producing Cells / Q000166:cytology; D000942:Antigens, Bacterial / Q000008:administration & dosage*; D001323:Autoantibodies / Q000096:biosynthesis*; D002002:Brucella / Q000276:immunology*; D002452:Cell Count; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D007114:Immunization; D007117:Immunization, Secondary; D051379:Mice; D012482:Salmonella paratyphi A / Q000276:immunology*; D013154:Spleen / Q000166:cytology
chemical_list: D000942:Antigens, Bacterial; D001323:Autoantibodies
vernacular_title: Osobennosti ranneĭ autoimmunoĭ reaktsii u vaktsinirovannykh i revaktsinirovannykh zhivotnykh.