[Adaptation to hypoxia in liver cirrhosis: the role of 2,3-DPG (author's transl)].
By observing a group of 20 patients with liver cirrhosis, we have clarified some features concerning the tissue hypoxia, which is often present in such a disease. By determining the levels of the haemoglobin and of the intraerythrocytic 2,3-DPG, and by evaluating the acid-base state of such patients, we have emphasized the increased output of the 2,3-DPG as mechanism of adaptation to hypoxia associated with hepatic cirrhosis, both in subjects with anemia and alkalosis and in subjects without anemia but with alkalosis.
D019794:2,3-Diphosphoglycerate; D004163:Diphosphoglyceric Acids / Q000097:blood*; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood / Q000378:metabolism*; D010101:Oxygen Consumption
D004163:Diphosphoglyceric Acids; D006454:Hemoglobins; D019794:2,3-Diphosphoglycerate
Meccanismi di compenso all'ipossia in corso di epatocirrosi: ruolo del 2,3-DPG.