title: [Thrombocyte aggregation after abdominal hysterectomy with combined prevention of thromboembolism using 6% macrodex and sintrom].
abstract: Thrombocyte aggregation was investigated, according to Born, in 14 patients who underwent abdominal hysterectomy due to benign illness. The patients received dextran 60 and 4-hydroxycoumarin as prophylactic therapy for early and late thromboembolism. The following results were obtained: 1. The ability of the thrombocytes to aggregate was reduced by half, 2 hours postoperatively, after administration of dextran 60, and remained at this level during the first postoperative day. This action was independent of the concentration and type of agent used in the aggregation test. The original values were attained again on the 4th postoperative day. The speed and force of desaggregation showed reverse behaviour. 2. Results bore no relationships to the age of the patient. 3. This combined prophylactic therapy with macrodex (500 ml intraoperatively) and sintrom (from the 1st postoperative day) seems to give adequate protection in both the intra- and postoperative risk phases.
mesh_terms: D015110:4-Hydroxycoumarins / Q000627:therapeutic use*; D000328:Adult; D003911:Dextrans / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects*; D011182:Postoperative Care; D013923:Thromboembolism / Q000517:prevention & control*
chemical_list: D015110:4-Hydroxycoumarins; D003911:Dextrans
vernacular_title: Die Thrombozytenaggregation nach abdominaler Hysterektomie unter kombinierter Thromboembolieprophylaxe mit Macrodex 6% und Sintrom.