[Involvement of both H1- and H2-receptors in the depressor responses of blood pressure to histamine in the rat (author's transl)].
Histamine caused a dose-dependent fall in blood pressure. This dose-response curve could be shifted to the right by administration of dimethylaminoethyl-N-p-methoxybenzyl-N-alpha-aminopyridine (mepyramine; H1-antagonist). 1-Methyl-([(5-methyl-4-imidazolyl)-2-methylthio]-3-ethyl)-2-thiourea (metiamide; H2-antagonist) alone had no effect on the histamine dose-response curve. The combination of both antagonists caused a further dose-dependent shift to the right. These results found in anaesthetized rats indicate the presence of both histamine receptors in the circulatory system of the rat.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006632:Histamine / Q000494:pharmacology*; D008297:Male; D008785:Metiamide / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology*; D011738:Pyrilamine / Q000494:pharmacology*; D051381:Rats; D011968:Receptors, Histamine / Q000187:drug effects*; D011969:Receptors, Histamine H1 / Q000187:drug effects; D011970:Receptors, Histamine H2 / Q000187:drug effects
D011725:Pyridines; D011968:Receptors, Histamine; D011969:Receptors, Histamine H1; D011970:Receptors, Histamine H2; D008785:Metiamide; D006632:Histamine; D011738:Pyrilamine
Uber die Beteiligung der Histamin H1- und H2-Rezeptoren an der durch Histamin ausgelösten Blutdrucksenkun