Protein and isoamylase content of rat-submaxillary gland under the influence of alpha- and beta-sympathicolysis.
In order to study the function of adrenergic receptors in the submaxillary gland in vivo, rats were treated with the alpha-sympathicolytic, phentolamine (Regitin) and with the beta-sympathicolytic, propranolol (Dociton) and the protein, amylase, and isoamylase content of their submaxillary glands were investigated. The protein concentration rises after 3 weeks of alpha- as well as combined alpha- and beta-sympathicolysis while the amylase concentrations remain, on the whole, unchanged. The pharmacologically induced secretory inhibitions are being discussed in connection with the generally accepted receptor functions.
D000818:Animals; D005260:Female; D006026:Glycoside Hydrolases / Q000378:metabolism*; D007517:Isoamylase / Q000378:metabolism*; D010646:Phentolamine / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology*; D011506:Proteins / Q000378:metabolism; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects; D011950:Receptors, Cholinergic / Q000187:drug effects; D013363:Submandibular Gland / Q000201:enzymology / Q000378:metabolism*
D011506:Proteins; D011941:Receptors, Adrenergic; D011950:Receptors, Cholinergic; D011433:Propranolol; D006026:Glycoside Hydrolases; D007517:Isoamylase; D010646:Phentolamine