Fluorescein and indocyanine green fluorescence angiography in study of affected males and in female carriers with choroidermia. A preliminary report.
26 males and 13 female carriers of different ages with choroideremia of varying severity were investigated using sodium fluorescein (FAG) and/or indocyanine green (ICG) fluorescence angiography. Females with minor changes present in pigment epithelium amy stay unchanged throughout life or gradually develop into a more advanced stage resembling the fundus picture of severely affected males. In moderately affected females there is a patchy degeneration of pigment epithelium in the macula. Peripapillary degeneration is seen also in indocyanine green fluorescence angiograms. In males, atrophic areas and the remaining choriocapillaris are clearly demonstrated in FAG and less well visible in ICG angiograms. ICG angiograms show choroidal vessels more clearly in cases where the pigment epithelium and the choriocapillaris are still present. In advanced cases in males and females, the choroidal blood circulation is slow.
D000293:Adolescent; D000328:Adult; D001284:Atrophy; D002648:Child; D002829:Choroid / Q000098:blood supply; D005260:Female; D005451:Fluorescein Angiography; D005452:Fluoresceins; D006801:Humans; D007208:Indocyanine Green; D008268:Macular Degeneration / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D010857:Pigment Epithelium of Eye; D012039:Regional Blood Flow; D012162:Retinal Degeneration / Q000175:diagnosis; D012737:Sex Factors
D005452:Fluoresceins; D007208:Indocyanine Green