Trichloroethylene and 1,1,1-trichloroethane: effects on brain and liver after five days intermittent inhalation.
The inhalation exposure of adult male rats to 7.9 mumol/l (200 ppm) of trichloroethylene for 4 days 6 h each day led to an accumulation of the solvent in the perirenal fat 17 h after the last exposure. Exposures to 20 mumol/l (500 ppm) of 1,1,1-trichloroethane caused similar accumulation. The latter rats presented no changes in their behaviour in an open-field test whereas the motor behaviour of the animals exposed to trichloroethylene was more active in comparison to controls 1 h after the exposure on the 4th day. Trace effects of trichloroethylene on emotional behaviour of the same rats could be seen 17 h after the last exposure. Further exposures on the 5th day increased brain, liver, lung and blood contents of trichlorethylene and 1,1,1-trichloroethane. A slight decrease in brain RNA content was found in the 1,1,1-trichloroethane exposed rats while RNA decreased significantly after the fifth day of trichloroethylene inhalation. The exposure to 1,1,1-trichloroethane on the 5th day depressed also the microsomal cytochrome P-450 content in liver of rats whereas trichloroethylene increased the hemochrome content slightly at the same time.
D000818:Animals; D001921:Brain / Q000187:drug effects*; D003672:Defecation / Q000187:drug effects; D006843:Hydrocarbons, Chlorinated / Q000494:pharmacology*; D001239:Inhalation; D008099:Liver / Q000187:drug effects*; D008297:Male; D051381:Rats; D014240:Trichloroethanes / Q000494:pharmacology*; D014241:Trichloroethylene / Q000494:pharmacology*; D014554:Urination / Q000187:drug effects
D006843:Hydrocarbons, Chlorinated; D014240:Trichloroethanes; D014241:Trichloroethylene