Amyotrophic lateral sclerosis in a high selenium environment.
During a ten-year period, four cases of amyotrophic lateral sclerosis have been found in a sparsely populated county (population 4,000) in west-central South Dakota. The patients were unrelated male farmer-ranchers between 57 and 66 years of age, living within a 15-km radius of each other. The cases occurred in a region where naturally occurring selenium toxication is endemic in farm animals.
D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000139:chemically induced*; D004196:Disease Outbreaks; D004781:Environmental Exposure; D005506:Food Contamination; D006801:Humans; D008297:Male; D008875:Middle Aged; D012643:Selenium / Q000032:analysis / Q000633:toxicity*; D012737:Sex Factors; D012987:Soil / Q000032:analysis; D013023:South Dakota
D012987:Soil; D012643:Selenium