Some aspects of aminoglycoside antibiotic measurement.
More than 2 years of experience in assaying aminoglycoside antibiotic levels have proved that the appropriate acetyltransferase employed in conjunction with 14C-acetyl co-enzyme A provides rapid, reproducible results (CV = 4+). These results are available before the next administration is due, enabling the clinician to adjust the dose. This is especially indicated if there is impairment of renal function.
D000123:Acetyltransferases; D000583:Amikacin / Q000097:blood; D000617:Aminoglycosides / Q000097:blood; D000900:Anti-Bacterial Agents / Q000097:blood*; D005839:Gentamicins / Q000097:blood; D006801:Humans; D014031:Tobramycin / Q000097:blood
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D005839:Gentamicins; D000583:Amikacin; D000123:Acetyltransferases; D014031:Tobramycin