title: Effects of halothane on microtubules in the sciatic nerve of the rat.
abstract: The effect of halothane and colchicine on microtubule repolymerisation after exposure to cold has been examined in the sciatic nerve of the rat. Myelinated axons showed a significant decrease in microtubule numbers and density after exposure to both 20 mM halothane and 10(-5) M colchicine; exposure to both agents simultaneously produced a further significant reduction when compared to halothane alone. It is suggested that halothane can interfere with microtubule repolymerisation in mammalian axons possibly in a similar way to that described in invertebrates.
mesh_terms: D000818:Animals; D001369:Axons / Q000187:drug effects / Q000648:ultrastructure; D003078:Colchicine / Q000494:pharmacology; D003599:Cytoskeleton / Q000648:ultrastructure; D004357:Drug Synergism; D006221:Halothane / Q000494:pharmacology*; D008297:Male; D008870:Microtubules / Q000187:drug effects* / Q000648:ultrastructure; D051381:Rats; D012584:Sciatic Nerve / Q000187:drug effects* / Q000648:ultrastructure
chemical_list: D003078:Colchicine; D006221:Halothane