Predicting phenytoin dose - a revised nomogram.
The nomogram devised by Richens and Dunlop for predicting phenytoin dose has been tested in 127 residential epileptic patients, and the data obtained were used to prepare a revised version of the nomogram. In a further 78 patients, this new version was found to be superior to the original. The mean Km value was found to be 23.8 mumoles/liter. Km was independent of age and body surface area, but Dmax correlated positively with the latter two variables.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D004827:Epilepsy / Q000188:drug therapy; D006801:Humans; D007700:Kinetics; D008875:Middle Aged; D010672:Phenytoin / Q000008:administration & dosage* / Q000097:blood
D010672:Phenytoin