Effects of two cannabinoids upon abstinence signs in ethanol-dependent mice.
The effects of delta9-tetrahydrocannabinol (THC) and nabilone, a synthetic cannabinoid, upon handling-induced convulsions and responsiveness to electric foot shock were examined during abstinence in ethanol-dependent mice. The severity of handling-induced convulsions was apparently increased by THC (10-40 mg/kg) and nabilone (2.5-10 mg/kg) but both drugs elicited similar convulsions in normal mice never exposed to ethanol. Enhanced responsiveness to electric foot shock, evident during abstinence, was suppressed by THC (10-40 MG/KG). The effects of ethanol upon the two abstinence signs were determined for comparative purposes. Ethanol (0.5-4 g/kg) reduced the severity of handling-induced convulsions and suppressed the increased responsiveness to electric foot shock. These results indicate that THC and nabilone have similar actions upon two abstinence signs in ethanol-dependent mice, and although one sign (responsiveness to electric foot shock) was clearly alleviated, another (handling-induced convulsions) was not.
D000428:Alcohol Drinking; D000437:Alcoholism / Q000188:drug therapy / Q000523:psychology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002186:Cannabinoids / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D013759:Dronabinol / Q000031:analogs & derivatives / Q000494:pharmacology; D004597:Electroshock; D000431:Ethanol / Q000494:pharmacology; D006801:Humans; D008297:Male; D051379:Mice; D011720:Pyrazoles / Q000494:pharmacology; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy / Q000523:psychology*
D002186:Cannabinoids; D011720:Pyrazoles; D000431:Ethanol; D013759:Dronabinol