Investigation of the liver glycogen level in rats treated with anticonceptives.
The results of our experiments with carbohydrate metabolism confirmed that 1. the gestagen component of norethynodrel (Infecundin) causes a more explicit increase of the liver glycogen level than that of ethynodioldiacetate (Bisecurin); 2. among oestrogens mestranol (Infecundin) gives a higher glycogen production in the liver than ethinyloestradiol (Bisecurin); 3. the greatest increase of liver glycogen level is in the course of the acute (14 days') treatment period; 4. the active substances of Infecundin (first of all mestranol) produce a longer lasting effect on the quantity of liver glycogen than those of Bisecurin; 5. to this action of the drug molecules of both anticonceptives (Infecundin, Bisecurin) there is a tendency to habituation. After a treatment lasting 48 days, the liver glycogen level in comparison with the control did but slightly increase; 6. evaluable changes occur sooner in the glycogen level of rats treated with hormonal contraceptives prior to the generally used so-called liver function test becoming positive.
D000818:Animals; D003276:Contraceptives, Oral / Q000494:pharmacology*; D003278:Contraceptives, Oral, Hormonal / Q000494:pharmacology*; D004997:Ethinyl Estradiol / Q000494:pharmacology; D005260:Female; D008112:Liver Glycogen / Q000378:metabolism*; D008656:Mestranol / Q000494:pharmacology; D009641:Norethynodrel / Q000494:pharmacology; D051381:Rats
D003276:Contraceptives, Oral; D003278:Contraceptives, Oral, Hormonal; D008112:Liver Glycogen; D004997:Ethinyl Estradiol; D009641:Norethynodrel; D008656:Mestranol