Experimental modifications induced by membrane oxygenators on lung ultrastructure in dogs and baboons.
Extracorporeal circulation with membrane oxygenator (E.C.M.O.) was performed in 6 dogs and 5 baboons during 4 to 57 hours. Examination of pulmonary samples showed progressive lesions in the two species: at the second hour of E.C., alteration of capillary endothelium, at the sixth, extensive lesions of all the lung structures, worsening later on. We discussed whether these lesions are related to the E.C.M.O., their reversibility and the questionable benefit of E.C.M.O. for management of respiratory distress syndrome.
D000818:Animals; D002196:Capillaries / Q000473:pathology; D004285:Dogs; D004727:Endothelium / Q000473:pathology; D008168:Lung / Q000098:blood supply / Q000648:ultrastructure*; D055370:Lung Injury; D010107:Oxygenators, Membrane / Q000009:adverse effects*; D010215:Papio; D012131:Respiratory Insufficiency / Q000628:therapy