Failure of 2,4,6-triaminopyrimidine (TAP) to block sodium pathways in a "leaky" epithelium: the urinary bladder of the trout.
The organic cation 2, 4, 6 - Triaminopyrimidine (TAP) used to block sodium permeability across leaky epithelia is ineffective on isolated urinary bladder of the trout. This observation suggests that this membrane does not present cation-selective paracellular pathways.
D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects; D011743:Pyrimidines / Q000494:pharmacology*; D012487:Salmonidae / Q000502:physiology*; D012964:Sodium / Q000378:metabolism*; D014337:Trout / Q000502:physiology*; D001743:Urinary Bladder / Q000187:drug effects / Q000378:metabolism*
D007473:Ion Channels; D011743:Pyrimidines; D012964:Sodium