[Action of trazodone on the secretion of pituitary hormones. Behavior of prolactin and somatotropin].
The effect of i.v. trazpdone on PRL and GH was studied in normal subjects and in patients with hypophyseal adenoma coupled with amenorrhoea and galactorrhoea or acromegaly. PRL levels were reduced, whereas the behaviour of GH was paradoxical. These results suggest that the dopaminergic and serotoninergic systems take part in regulating the secretion of these two hormones. An interesting comparison was made with their behaviour following the administration of bromoergocryptine in the adenoma series.
D000172:Acromegaly / Q000188:drug therapy*; D000236:Adenoma / Q000188:drug therapy; D000328:Adult; D000568:Amenorrhea / Q000188:drug therapy*; D005260:Female; D005687:Galactorrhea / Q000188:drug therapy*; D013006:Growth Hormone / Q000378:metabolism; D006801:Humans; D007775:Lactation Disorders / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000627:therapeutic use*; D010903:Pituitary Gland, Anterior / Q000187:drug effects*; D010908:Pituitary Hormones, Anterior / Q000378:metabolism*; D010911:Pituitary Neoplasms / Q000188:drug therapy*; D011247:Pregnancy; D011388:Prolactin / Q000378:metabolism; D014196:Trazodone / Q000494:pharmacology / Q000627:therapeutic use*
D010879:Piperazines; D010908:Pituitary Hormones, Anterior; D011388:Prolactin; D013006:Growth Hormone; D014196:Trazodone
Studio dell'azione del trazodone sulla secrezione di ormoni ipofisari. Comportamento della prolattina e del somatotropo.