[Regarding the effect of bromhexine metabolite VII on lecithin synthesis in fetal lungs (author's transl)].
With the help of incorporated amounts of radioactively labeled choline, it was shown that bromhexine metabolite VIII in vivo (10 mg, 5 mg, 1 mg/kg body weight) and in vitro (100 microgram to 0,01 microgram/g fetal lung tissue) does not stimulate lecithin synthesis in fetal lungs of rats.
D000551:Ambroxol / Q000494:pharmacology*; D000818:Animals; D001964:Bromhexine / Q000031:analogs & derivatives*; D002794:Choline / Q000378:metabolism; D005260:Female; D066298:In Vitro Techniques; D008168:Lung / Q000196:embryology* / Q000378:metabolism; D011247:Pregnancy; D011663:Pulmonary Surfactants / Q000096:biosynthesis*; D051381:Rats
D011663:Pulmonary Surfactants; D000551:Ambroxol; D002794:Choline; D001964:Bromhexine
Zur Wirkung von Bromhexine Metabolit VIII auf die Lezithinsynthese in der fetalen Lunge.