[Effect of cesium, lithium and rubidium on several effects of morphine].
The effect of chlorous salts of cesium, lithium, and rubidium on the analgetic action of morphine (according to the vocalization test) and also on the pattern of the dependence on it (according to the so-called "two-bottle test") was studied. As shown, the salts under investigation decreased both the algesic reaction threshold and the duration of morphine-induced analgesia; cesium chloride proved most active in this respect. All the compounds studied decrease the morphine preference coefficient. The greatest effect was found in cesium chloride which decreased the morphine preference coefficient 40-fold as compared to the control.
D000818:Animals; D002586:Cesium / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008094:Lithium / Q000494:pharmacology* / Q000627:therapeutic use; D009020:Morphine / Q000037:antagonists & inhibitors* / Q000627:therapeutic use; D009021:Morphine Dependence / Q000188:drug therapy; D010146:Pain / Q000188:drug therapy; D051381:Rats; D012413:Rubidium / Q000494:pharmacology* / Q000627:therapeutic use
D002586:Cesium; D009020:Morphine; D008094:Lithium; D012413:Rubidium
Vliianie tseziia, litiia i rubidiia na nekotorye éffekty morfina.