title: A report of the histological features in 12 cases of gonadoblastoma.
abstract: This report deals with 12 cases of gonadoblastoma submitted to the Ovarian Tumour Panel of the Royal College of Obstetricians and Gynaecologists. These tumours are found in children and young adults. Children may present with obvious genital malformation, retarded growth or precocious puberty. In adults the main compliant is amenorrhoea but sometimes there is associated masculinization. Histologically the gonadoblastoma has a distinctive structure, easily recognized in most instances. The most important feature is the instability of the germ cells in these tumours. Nine of these cases showed an associated dysgerminoma, bilateral in 4. In any cases of suspected gonadal dysgenesis presumptive evidence of diagnosis is suggested by the presence of a Y chromosome, raised gonadotrophin output and pelvic calcification on X-ray examination. At operation, streak tissue on both sides must be removed since these tumours are frequently microscopic in size. For the same reason the tissue removed should be serially sectioned.
mesh_terms: D000293:Adolescent; D000328:Adult; D000568:Amenorrhea / Q000209:etiology; D002648:Child; D004407:Dysgerminoma / Q000150:complications / Q000175:diagnosis / Q000235:genetics / Q000473:pathology*; D005260:Female; D006062:Gonadotropins / Q000097:blood; D006801:Humans; D007223:Infant; D008297:Male; D010051:Ovarian Neoplasms / Q000235:genetics / Q000473:pathology*; D014770:Virilism / Q000209:etiology; D014998:Y Chromosome
chemical_list: D006062:Gonadotropins