[Effect of prostaglandins on embryonal myocardium].
In tests set up with cultivated isolated cells and explants of the myocardium of 3- and 7-day chicken embryos a positive inotropic and less marked positive chronotropic action of prostaglandins (PG) were disclosed. These effects of PG are fully blocked with polyphloretin phosphate and by addition to the incubation medium of ethylene-glycol-bis (beta-aminoethyl)N,N1-tetraacetate (EGTA), whereas in increased Ca2+ concentration in the nutrient medium potentiates the inotropic effects of PGE1. The data obtained suggest that the cardiostimulating action of PG is realized through the specific prostaglandin-sensitive myocardium receptors.
D000818:Animals; D002478:Cells, Cultured; D002642:Chick Embryo; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006321:Heart / Q000196:embryology*; D006339:Heart Rate / Q000187:drug effects*; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000032:analysis; D009924:Organ Culture Techniques; D011453:Prostaglandins / Q000494:pharmacology*; D011454:Prostaglandins A / Q000494:pharmacology; D011458:Prostaglandins E / Q000494:pharmacology; D011460:Prostaglandins F / Q000494:pharmacology; D011982:Receptors, Prostaglandin / Q000032:analysis
D011453:Prostaglandins; D011454:Prostaglandins A; D011458:Prostaglandins E; D011460:Prostaglandins F; D011982:Receptors, Prostaglandin
O vliianii prostaglandinov na émbrional'nyĭ miokard..