[Pharmacological modification of evoked caudate nucleus potentials].
To stimulation of the Substantia nigra the nucleus caudatoputamen of the rat responds with the release of a short-latent sum action potential that may serve to characterize the interaction between the two nuclear areas. The partly conflicting results reported in the literature about drug effects on this potential prompted us to examine the effectiveness of dopaminergic and cholinergic substances or their antagonists following systematic administration. Chloropromazine increases the amplitude of the potential, while apomorphine has a distinct antagonistic effect. Interesting appear to be the analogical effects of Tricuran, arecoline and apomorphine, and the furtherance of the chloropromazine effect by arecoline.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001115:Arecoline / Q000494:pharmacology; D001285:Atropine / Q000494:pharmacology; D001337:Autonomic Agents / Q000494:pharmacology*; D002421:Caudate Nucleus / Q000187:drug effects* / Q000502:physiology; D002746:Chlorpromazine / Q000494:pharmacology; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D005703:Gallamine Triethiodide / Q000494:pharmacology; D011699:Putamen / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D013378:Substantia Nigra / Q000502:physiology*
D001337:Autonomic Agents; D001115:Arecoline; D001285:Atropine; D001058:Apomorphine; D005703:Gallamine Triethiodide; D002746:Chlorpromazine
Pharmakologische Beeinflussung von ausgelösten Caudatus-Potentialen.