title: The effects of prostaglandin and mating on release of LH in the female rabbit.
abstract: The release of LH in response to prostaglandin (PG) treatment of female rabbits in various reproductive states was compared with the surge following mating. Intracarotid infusion of PGE-2 or PGF-2alpha (0-3--900 microgram/h) into non-receptive and pseudopregnant does resulted in small, 2--4-fold elevations in jugular vein LH concentration. Similar doses of PGF-2alpha in oestrogen-pretreated, oestrous does stimulated a 13-fold increase in plasma LH levels. Mating resulted in a much larger release of LH, as plasma levels increased approximately 60-fold from 1-1 +/- 0-2 (S.E.M.) ng/ml to 67-8 +/- 10-5 ng/ml. These results indicate that PG can stimulate the hypothalamic-hypophysial axis to release LH in non-receptive, pseudopregnant and oestrogen-pretreated, oestrous rabbits.
mesh_terms: D000818:Animals; D003307:Copulation; D004971:Estrus; D005260:Female; D007986:Luteinizing Hormone / Q000097:blood / Q000378:metabolism*; D008297:Male; D011247:Pregnancy; D011458:Prostaglandins E / Q000494:pharmacology*; D011460:Prostaglandins F / Q000494:pharmacology*; D011817:Rabbits; D013268:Stimulation, Chemical
chemical_list: D011458:Prostaglandins E; D011460:Prostaglandins F; D007986:Luteinizing Hormone