title: [The efficacy of established, systemically active trichomonacidal agents in the infection model tri-chomonas vaginalis/rat (author's transl)].
abstract: Experimental chemotherapeutical studies were carried out with metronidazole, tinidazole, nitrimidazine and ornidazole in rats infected with Trichomonas vaginalis intravaginally. All compounds tested showed a systemic trichomonacidal activity within rather a narrow dosage range after three oral doses and also after a single dose, i.e., 1.4-3.0 mg/kg and 7.7-15.9 mg/kg body weight (DC50), respectively.
mesh_terms: D000818:Animals; D000994:Antitrichomonal Agents / Q000627:therapeutic use*; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005260:Female; D051381:Rats; D014247:Trichomonas Vaginitis / Q000188:drug therapy*
chemical_list: D000994:Antitrichomonal Agents
vernacular_title: Die Wirksamkeit bekannter systemisch wirksamer Trichomonazide im Infektionsmodell Trichomonas vaginalis/ratte