Control of carnitine-related metabolism during myocardial ischemia.
Induction of ischemia in the open-chest dog or isolated rat heart caused a series of critical changes in carnitine-related metabolism. As a result of these metabolic changes, the LCACA/carnitine ratio rapidly increased which, in turn, may have reduced the activity of mitochondrial ANT and a number of other enzyme systems necessary for normal heart function. Carnitine administration apparently reversed these carnitine-linked metabolic changes and protected the ischemic myocardium. Possible mechanisms for the protective action of carnitine were discussed.
D000332:Aerobiosis; D000818:Animals; D001692:Biological Transport; D002331:Carnitine / Q000378:metabolism*; D002332:Carnitine O-Acetyltransferase / Q000378:metabolism; D002463:Cell Membrane Permeability; D003327:Coronary Disease / Q000378:metabolism*; D004195:Disease Models, Animal; D004285:Dogs; D000860:Hypoxia / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D051381:Rats
D002332:Carnitine O-Acetyltransferase; D002331:Carnitine