Respiratory function following premedication with droperidol or diazepam.
Respiratory function was measured before and 1 hour after premedication with diazepam (10 mg IM) or droperidol (5 mg IM) in 2 groups of 14 normal patients scheduled for elective surgery. Diazepam had no significant effects on respiratory rate, tidal volume, minute ventilation, dead space, VD/VT %, alveolar ventilation, expired Po2, or Pco2, end-tidal Pco2, arterial Po2 or Pco2, or alveolar-arterial Po2 or Pco2 gradients. Droperidol was associated with statistically significant but modest reductions in tidal volume (-13.3%) and minute ventilation (-8.4%) while other respiratory functions remained unaffected.
D000328:Adult; D003864:Depression, Chemical; D003975:Diazepam / Q000008:administration & dosage / Q000009:adverse effects*; D004329:Droperidol / Q000008:administration & dosage / Q000009:adverse effects*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D011229:Preanesthetic Medication / Q000009:adverse effects* / Q000379:methods; D012119:Respiration / Q000187:drug effects*; D012129:Respiratory Function Tests; D013997:Time Factors
D004329:Droperidol; D003975:Diazepam