Serotonin levels in the blood and central nervous system of a patient with sudanophilic leukodystrophy.
A case report is presented of a boy with the infantile spasm syndrome beginning at eight months of age. He had a clinical course marked by increasingly severe seizures and neurological regression. After death at twenty-one months of age, autopsy of the central nervous system revealed demyelination of white matter with sparing of arcuate fibers. An earlier born male sibling had had a similar clinical pattern but died without an autopsy. During his lifetime, the patient had markedly elevated levels of 5-hydroxyindoles (a measure of serotonin) in his blood. At autopsy, the level of 5-hydroxytryptamine (serotonin) in four grey matter areas of the brain was lower than those of a control who died on the same day. This is the first case reporting a comparison of blood and central nervous system levels of 5-hydroxytrypamine in a child.
D000367:Age Factors; D001321:Autistic Disorder / Q000097:blood; D002547:Cerebral Palsy / Q000097:blood; D006801:Humans; D007223:Infant; D008607:Intellectual Disability / Q000097:blood; D007968:Leukoencephalopathy, Progressive Multifocal / Q000097:blood* / Q000235:genetics; D008297:Male; D012598:Sclerosis / Q000097:blood / Q000235:genetics; D012701:Serotonin / Q000097:blood*; D013577:Syndrome
D012701:Serotonin