Studies on the inhibitory effect of lectins on myxo-virus release.
Lectins of different specificities do not interfere with the maturation of myxo-viruses; their inhibitory effect on virus replication is mainly due to prevention of the detachment of infectious virus particles from the host cell. In chick embryo fibroblasts infected with an influenza virus and treated with concanavalin A, budding occurs into intracytoplasmic vacuoles, but this phenomenon is not observed with a parainfluenza virus and with different cells.
D000818:Animals; D002642:Chick Embryo; D003208:Concanavalin A / Q000494:pharmacology; D046508:Culture Techniques; D009980:Influenza A virus / Q000254:growth & development* / Q000302:isolation & purification; D037102:Lectins / Q000494:pharmacology*; D008766:Methylmannosides / Q000494:pharmacology; D009522:Newcastle disease virus / Q000254:growth & development* / Q000302:isolation & purification; D013010:Sonication; D014617:Vacuoles / Q000382:microbiology; D014779:Virus Replication / Q000187:drug effects*
D037102:Lectins; D008766:Methylmannosides; D003208:Concanavalin A