title: [Histochemical investigation on the mechanism of action of a synthetic mucolytic compound (Na 872 Cl): preliminary results].
abstract: A histochemical study about mucolytic capacity of Na872Cl compound revealed its action upon epitelial mucins of mouse colonic and tracheal mucosa but the results depend on the chemical type of fixative employed (formalin or acetone fixed sections); the mode of action especially regarding the influence of fixatives and the nature of sensitive substrates are discussed.
mesh_terms: D000551:Ambroxol / Q000494:pharmacology*; D000818:Animals; D001964:Bromhexine / Q000031:analogs & derivatives*; D005100:Expectorants / Q000138:chemical synthesis / Q000494:pharmacology*; D006651:Histocytochemistry; D007413:Intestinal Mucosa / Q000187:drug effects / Q000378:metabolism*; D051379:Mice; D009092:Mucous Membrane / Q000187:drug effects / Q000378:metabolism*; D014132:Trachea / Q000187:drug effects / Q000378:metabolism*
chemical_list: D005100:Expectorants; D000551:Ambroxol; D001964:Bromhexine
vernacular_title: Indagine istochimica sul meccanismo d'azione di un mucolitico di sintesi (Na 872 Cl): risultati preliminarai.