[Binding capacity of testosterone estradiol binding globulin (TeBG) in normal children and in children with endocrine pathology].
The binding capacity of plasma TeBG was measured by polyacrylamide gel electrophoresis. In normal prepubertal children the values are identical in the two sexes boys (6.23 +/- 1.72 microgram/dl); girls (6.21 +/- 1.93 microgram/dl). In boys puberty induces an immediate and highly significant (p less than 0.001) drop in TeBG (1.79 +/- 0.75 microgram/dl) while it remains unchanged in girls (5.34 +/- 0.92 microgram/dl). In newborn males there is a physiological rise in plasma testosterone in the first months of life with a parallel rise in TeBG. In boys with precocious puberty the drop in TeBG is delayed in comparison to the rise in plasma testosterone. The pubertal drop of TeBG is delayed and incomplete in boys with male pseudohermaphroditism. The data indicates that the measurement of TeBG binding capacity can be used as an indirect method to evaluate the peripheral effect of testosterone. The lack of effect of HCG on TeBG means that this test is of no value as a functional assessment of prepubertal subjects.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D012734:Disorders of Sex Development / Q000097:blood*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007713:Klinefelter Syndrome / Q000097:blood*; D008297:Male; D011485:Protein Binding; D011627:Puberty; D011629:Puberty, Precocious / Q000097:blood*; D012737:Sex Factors; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism*; D013739:Testosterone / Q000097:blood
D006063:Chorionic Gonadotropin; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone
Etude de la capacité de fixation de la testosterone estradiol binding globulin (TeBG) chez l'enfant normal et en pathologie endocrinienne de l'enfant.