[Participation of hematopoietic stem cells in the process of immune response formation].
The endogenous colony formation and immunogenesis in mice of CBA and C57BL strains immunized with various doses of sheep red blood cells (SRBC) were studied. An absolute or relative increase of antibody forming cells under the action of growing SRBC dose from 2.10(7) to 2.10(8) as well as a decrease following 2.10(9) dose administration were noted. The number of endogenous hemopoietic spleen colonies augmented depending on increased antigen dose. Strain differences in the number of endogenous spleen colonies remained. It is suggested that the stimulation mode of hemopoietic lines is based on a specific RES blockade by SRBC resulting in enhanced proliferative effect of stem cells.
D000818:Animals; D000921:Antibody-Producing Cells; D000941:Antigens; D003114:Colony-Forming Units Assay; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006412:Hematopoietic Stem Cells / Q000276:immunology*; D007114:Immunization; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D012756:Sheep / Q000276:immunology
D000941:Antigens
Uchastie stvolovykh krovetvornykh elementov v protsesse formirovaniia immunnogo otveta.