Acute demyelinating disease in a chimpanzee three years after inoculation of brain cells from a patient with MS.
Brain cells from a patient with classic multiple sclerosis were inoculated intracerebrally into the frontal lobe of a newborn chimpanzee. The animal developed acute quadriplegia three years, two months later and was killed four days after the onset of symptoms. Central nervous system lesions were primarily localized in the spinal cord at root entry zones; these were characterized by demyelination and regeneration of myelin by Schwann cells.
D000818:Animals; D003711:Demyelinating Diseases / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D008854:Microscopy, Electron; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000209:etiology; D002679:Pan troglodytes; D013116:Spinal Cord / Q000473:pathology* / Q000648:ultrastructure