title: Alternative pathways for proline synthesis in mammalian cells.
abstract: Proline is synthesized in animal cells by way of two alternative pathways. Both of these pathways are functional in many cell lines. The relative contribution of a pathway to total proline synthesis may be altered by a mutational event. Differences in the developmental origin of a cell line are retained as differences in the pathways of proline synthesis.
mesh_terms: D002460:Cell Line; D002875:Chromosomes; D005260:Female; D005971:Glutamates / Q000378:metabolism*; D007621:Karyotyping; D009952:Ornithine / Q000378:metabolism*; D009953:Ornithine-Oxo-Acid Transaminase / Q000378:metabolism; D010053:Ovary / Q000378:metabolism; D011392:Proline / Q000096:biosynthesis*
chemical_list: D005971:Glutamates; D011392:Proline; D009952:Ornithine; D009953:Ornithine-Oxo-Acid Transaminase