[Intraamnial application of 14C-labeled lecithine at man 13 hrs. ante partum (author's transl)].
It was examined, whether by intraamnial applicated lecithine an approaching respiratory distress syndrome could be prevented. This possibility of therapy was tested on a fetus unviable of life. It was shown by examining the lavage-fluid of the fetal lung, as well as the organ homogenates of lung; liver and gut, that the intraamnial applicated lecithine was metabolised and resynthesised in the organism. In the lung the lecithine was present as a complete molecule.
D000328:Adult; D000650:Amnion; D002250:Carbon Radioisotopes; D005260:Female; D005333:Fetus / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D007267:Injections; D007422:Intestines / Q000032:analysis; D008099:Liver / Q000032:analysis; D008168:Lung / Q000032:analysis; D010713:Phosphatidylcholines / Q000378:metabolism / Q000627:therapeutic use*; D011247:Pregnancy; D012127:Respiratory Distress Syndrome, Newborn / Q000517:prevention & control*; D013997:Time Factors
D002250:Carbon Radioisotopes; D010713:Phosphatidylcholines
Intraamniale Applikation von 14C-markiertem Lecithin beim Menschen 13 Stunden ante partum.