[Preventive effect of lithium chloride on the development in rats of a preference for ethanol].
It was revealed in experiments on rats treated with a 5% ethanol solution with equal quantities of LiCl (experiment) and NaCl (control) for seven weeks as the only source of liquid that with li+ concentration in the blood plasma of approximately 0.6 meq/1 LiCl prevented the development of alcohol dependence. On studying the neurosecretory hypothalamic nuclei, hypophysis and adrenal cortex of the same animals a certain correlation has been demonstrated between the morphofunctional condition of the mentioned formations, the degree of ethanol preference development and the character of LiCl influence on the process.
D000437:Alcoholism / Q000517:prevention & control*; D000818:Animals; D004353:Drug Evaluation, Preclinical; D000431:Ethanol / Q000037:antagonists & inhibitors*; D006801:Humans; D008094:Lithium / Q000097:blood / Q000627:therapeutic use*; D008297:Male; D009490:Neurosecretory Systems / Q000187:drug effects; D010286:Paraventricular Hypothalamic Nucleus / Q000187:drug effects; D051381:Rats; D012965:Sodium Chloride / Q000627:therapeutic use; D013495:Supraoptic Nucleus / Q000187:drug effects; D013997:Time Factors
D000431:Ethanol; D012965:Sodium Chloride; D008094:Lithium
Preventivnyi éffekt khlorida litiia na razvitie u krys predpochteniia k étanolu.