Mode of action of saframycin A, a novel heterocyclic quinone antibiotic. Inhibition of RNA synthesis in vivo and in vitro.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002466:Cell Nucleolus / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D007700:Kinetics; D007939:Leukemia L1210 / Q000378:metabolism; D011809:Quinones / Q000494:pharmacology; D012334:RNA, Neoplasm / Q000096:biosynthesis*; D013329:Structure-Activity Relationship; D014158:Transcription, Genetic / Q000187:drug effects
D000900:Anti-Bacterial Agents; D011809:Quinones; D012334:RNA, Neoplasm