title: [Investigations on the excretion of cefaclor in human bile (author's transl)].
abstract: The concentration of cefaclor in serum and bile was determined for up to 360 minutes after a single oral dose of 1 g cefaclor in 18 patients with continuous T-drainage of the bile duct. The rate of absorption varied, there being marked differences in the time. The peak bile concentration of 12.1 mcg/ml was reached after 120 min; the peak serum concentration of 12.3 mcg/ml, on the other hand, was reached after only 90 min. There was no accumulation of cefaclor in the bile.
mesh_terms: D000328:Adult; D000368:Aged; D001646:Bile / Q000032:analysis*; D002433:Cefaclor / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology; D002506:Cephalexin / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D002433:Cefaclor; D002506:Cephalexin
vernacular_title: Untersuchungen zur Exkretion von Cefaclor in menschlicher Galle.