Structure-anorectic activity relationships in substituted phenethylamines.
A series of phenylisopropylamine derivatives are compared with the correspondent beta-methoxy- and beta-hydroxy-phenethylamine compounds. Unlike amphetamine, the beta-methoxy phenethylamine has no anorectic activity. This property appears only with the introduction of a CF3 group on the benzene nucleus. The racemic N-alkyl derivatives are more active than the racemic or even the levorotatory N-benzyl compound. The beta-hydroxy-phenethylamines are devoid of anorectic activity.
D000818:Animals; D001066:Appetite / Q000187:drug effects; D001067:Appetite Depressants; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010627:Phenethylamines / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship
D001067:Appetite Depressants; D010627:Phenethylamines