Deuterated iodoacetanilide: a covalent protein label for neutron scattering studies.
A simple preparation of a deuterated alkylating reagent is described. Its reaction with the beta 93-SH groups of hemoglobin was used to illustrate the preparation of a protein derivative which contains 5 covalently attached non-exchangeable deuterium atoms at a unique locus on each beta chain.
D000083:Acetanilides; D000477:Alkylating Agents; D003903:Deuterium; D006454:Hemoglobins / Q000032:analysis; D009502:Neutrons; D011487:Protein Conformation; D012542:Scattering, Radiation / Q000379:methods*
D000083:Acetanilides; D000477:Alkylating Agents; D006454:Hemoglobins; C026848:4-iodoacetanilide; D003903:Deuterium