Microtubule reassembly-interactions between microtubules and pore complexes, endoplasmic reticulum and 100 A filaments in tumour cells in vitro.
100 A filaments and annulate lamellae were often observed in the vicinity of vinblastine-induced paracrystals in tumour cells treated with nocodazole. There was often a direct continuity between 100 A filaments and paracrystals. The assembly of microtubules was examined in nocodazole-treated cells with special attention to possible initiating sites. We found an apparent association of microtubules with pore like structures associated with the endoplasmic reticulum. A complex system of 100 A filaments, microtubules and endoplasmic reticulum was observed. The significance of these results is discussed.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001562:Benzimidazoles / Q000494:pharmacology*; D002219:Carbamates / Q000494:pharmacology*; D002460:Cell Line; D003593:Cytoplasm / Q000648:ultrastructure*; D003599:Cytoskeleton / Q000648:ultrastructure*; D004721:Endoplasmic Reticulum / Q000648:ultrastructure*; D051379:Mice; D008870:Microtubules / Q000648:ultrastructure*; D010954:Plasmacytoma; D014747:Vinblastine / Q000494:pharmacology*
D000970:Antineoplastic Agents; D001562:Benzimidazoles; D002219:Carbamates; D014747:Vinblastine