The influence of electro-acupuncture on naloxone-induced morphine withdrawal. II. Elevation of immunoassayable beta-endorphin activity in the brain but not the blood.
The effect of electro-acupuncture in the treatment of naloxone precipitated morphine withdrawal in mice was studied. Thirty minutes of acupuncture was enough to suppress withdrawal behaviors by more than 60%. Concomitant to the decrease of withdrawal behavior, there was a significant increase of brain beta-endorphin level in the acupunctured animals. Plasma beta-endorphin level of the treated and untreated group was not significantly different.
D015670:Acupuncture Therapy; D000818:Animals; D001923:Brain Chemistry; D004580:Electronarcosis; D004723:Endorphins / Q000032:analysis*; D005260:Female; D006801:Humans; D051379:Mice; D009021:Morphine Dependence / Q000628:therapy*; D009270:Naloxone; D011863:Radioimmunoassay; D013375:Substance Withdrawal Syndrome / Q000378:metabolism / Q000628:therapy*
D004723:Endorphins; D009270:Naloxone