Cardiac sensitization induced by phenobarbitone and prolonged by CS2.
The arrhythmogenic effect of 8 microgram/kg noradrenaline given i.v. was increased in male rats pretreated 1-2 days earlier with phenobarbitone and starved from the time  of the first phenobarbitone injection (80 mg/kg followed by 50 mg/kg 6 h later). Daily exposure to 4.0 mg/l CS2 (first exposure 24 h after the first phenobarbitone injection) for 4 h prevented the decline in susceptibility on the 3rd and 4th days after phenobarbitone, when the reaction of unexposed rats to noradrenaline returned to normal.
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced*; D002246:Carbon Disulfide / Q000494:pharmacology*; D004357:Drug Synergism; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D010634:Phenobarbital / Q000494:pharmacology*; D011674:Pulse / Q000187:drug effects; D051381:Rats; D013217:Starvation / Q000503:physiopathology; D013997:Time Factors
D002246:Carbon Disulfide; D009638:Norepinephrine; D010634:Phenobarbital