[Influence of pyridoxal-5'-phosphate on responses of isolated coronary arteries to noradrenaline, in the presence of pyrogallol].
The effect of PLP on the noradrenaline-induced relaxation of coronary arteries was studied in vitro, after known inhibitor of COMT, Pyrogallol. Relaxation of response to noradrenaline were increased by PLP. Pyrogallol potentiated responses of coronary strips to noradrenaline and also reduced or abolished the enhancing effects of PLP. It is concluded that PLP enhances the response of coronary smooth muscle to noradrenaline by inhibiting a enzymatic pathway for the inactivation of catecolamines.
D000818:Animals; D002417:Cattle; D003331:Coronary Vessels / Q000187:drug effects*; D004357:Drug Synergism; D066298:In Vitro Techniques; D009130:Muscle, Smooth / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology*; D011732:Pyridoxal Phosphate / Q000494:pharmacology*; D011748:Pyrogallol / Q000494:pharmacology*
D011748:Pyrogallol; D011732:Pyridoxal Phosphate; D009638:Norepinephrine
Influenza del piridossal-5'-fosfato sulle risposte di arterie coronarie isolate alla noradrenalina, in presenza di pirogallolo.