Abnormal-pursuit eye movements in schizophrenia. Evidence for a genetic indicator.
Disordered smooth-pursuit eye movements occur in a high percentage of schizophrenic patients and their first-degree relatives. A Test of the hypothesis that these disorders represent a genetic indicator of schizophrenia was undertaken by testing pursuit eye movements in a sample of monozygotic and dizygotic twins discordant for clinical schizophrenia. Deviant eye tracking is significantly concordant within monozygotic twin pairs, and less so with dizygotic twin pairs discordant for schizophrenia. A genetic interpretation is consistent with these results.
D000328:Adult; D000368:Aged; D004198:Disease Susceptibility; D004200:Diseases in Twins; D004584:Electronystagmography; D005133:Eye Movements; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D012559:Schizophrenia / Q000235:genetics*; D012931:Social Environment; D014429:Twins, Dizygotic; D014430:Twins, Monozygotic