The disposition of formaldehyde and formate arising from drug N-demethylations dependent on cytochrome P-450 in hepatocytes and in perfused rat liver.
D000633:Aminopyrine N-Demethylase / Q000378:metabolism; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D005557:Formaldehyde / Q000378:metabolism*; D005561:Formates / Q000378:metabolism*; D066298:In Vitro Techniques; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D008715:Methionine / Q000494:pharmacology; D008745:Methylation; D010084:Oxidation-Reduction; D010089:Oxidoreductases, N-Demethylating / Q000378:metabolism*; D010477:Perfusion; D051381:Rats
D005561:Formates; D005557:Formaldehyde; D003577:Cytochrome P-450 Enzyme System; D008715:Methionine; D010089:Oxidoreductases, N-Demethylating; D000633:Aminopyrine N-Demethylase