Stimulation of the conversion of penicillin N to cephalosporin by ascorbic acid, alpha-ketoglutarate, and ferrous ions in cell-free extracts of strains of Cephalosporium acremonium.
D000164:Acremonium / Q000187:drug effects / Q000378:metabolism*; D001205:Ascorbic Acid / Q000494:pharmacology*; D002511:Cephalosporins / Q000096:biosynthesis*; D007501:Iron / Q000494:pharmacology*; D007656:Ketoglutaric Acids / Q000494:pharmacology*; D007700:Kinetics; D010405:Penicillinase / Q000378:metabolism; D010406:Penicillins / Q000378:metabolism*
D002511:Cephalosporins; D007656:Ketoglutaric Acids; D010406:Penicillins; D007501:Iron; D010405:Penicillinase; D001205:Ascorbic Acid