Effects of octylguanidine on the electrical and mechanical events of xenopus heart.
The effects of octylguanide on the electrical and mechanical events of Xenopus heart perfused at the rate of 5 ml/m with oxigenated Ringer of ph 7,4 at 24 degrees C were studied. The early effects on the action potential resemble those of the tetrodotoxina, the later effects looks like instead as those observed with metabolic poisons. The cardiac preparations poisoned by octylguanidine still have a metabolic reserve available to furnish energy for the contractile process.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D006146:Guanidines / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects*; D007545:Isoproterenol / Q000494:pharmacology; D008564:Membrane Potentials / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects; D014981:Xenopus
D006146:Guanidines; D007545:Isoproterenol