title: High performance liquid chromatographic analysis of hydrochlorothiazide in serum and urine.
abstract: We report a high performance liquid chromatographic method for the analysis of hydrochlorothiazide in 500microliter of serum of 25 microliter of urine. The between-day precision of the analysis (CV 5.0-7.0%) is acceptable, as is the recovery of hydrochlorothiazide (90-96%) and trichloromethiazide (96%) added to serum. No drug or drug metabolite interferences have been noted. The method represents a considerable improvement over existing techniques described in the literature.
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004347:Drug Interactions; D006801:Humans; D006852:Hydrochlorothiazide / Q000032:analysis* / Q000097:blood / Q000652:urine
chemical_list: D006852:Hydrochlorothiazide