title: The effect of cyproheptadine on the chromosomes of human lymphocytes in vitro.
abstract: The effect of 4-[5-dibenzo(alpha,alpha)-cyclohepten-5-ylidene]-1-methylpiperidine (cyproheptadine, Periactinol) on the chromosomes of human lymphocytes in vitro was investigated. Cell cultures that had been established for 48 h from lymphocytes obtained from the peripheral blood of four volunteers were exposed for an additional 24 h to drug concentrations of 2.54 X 10(-5), 5.09 X 10(-5), 1.02 X 10(-4), or 2.03 X 10(-4) Mol/l. No variations or aberrations were seen in the chromosomes of human lymphocytes that could be definitely related to treatment with cyproheptadine.
mesh_terms: D000367:Age Factors; D002648:Child; D002875:Chromosomes / Q000187:drug effects*; D003533:Cyproheptadine / Q000009:adverse effects* / Q000494:pharmacology; D003582:Cytogenetics; D006801:Humans; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000187:drug effects*
chemical_list: D003533:Cyproheptadine