title: [Cerebral polyuric hyponatremia--discussion of a new syndrome with disturbance of electrolyte balance of central origin (author's transl)].
abstract: We have experienced with 50 cases of parasellar tumors, four cases of which had persistent thirst, polydipsia, polyuria, and reversible temporary hyponatremia secondary to hypernatriuresis. The mechanism of the syndrome in these four cases could not be explained by either that of the syndrome of hypernatremia or of the so-called SIADH. We tentatively named this syndrome as "CEREBRAL POLYURIC HYPONATREMIA" and the criteria of this syndrome as as follows: 1) persistent thirst, polydipsia polyuria, 2) reversible temporary hyponatremia secondary to hypernatriuresis, 3) exception of the following items--administration of uretic drugs, renal and adrenal dysfunction, hyperglycemia, hyperlipemia, overadministration of water, and poor administration of NaCl. The mechanism of this syndrome is presumed as follows: 1) compression by a tumor or surgical attack to the anterior hypothalamus, 2) disturbance of the mechanism of ADH secret-on, 3) extrasecretion of natriuretic factor possibly produced in the anterior hypthalamus, and 4) preservation of the thirst center.
mesh_terms: D000236:Adenoma / Q000150:complications / Q000378:metabolism; D000328:Adult; D001932:Brain Neoplasms / Q000150:complications* / Q000378:metabolism; D003397:Craniopharyngioma / Q000150:complications / Q000378:metabolism; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000150:complications* / Q000378:metabolism; D008297:Male; D008579:Meningioma / Q000150:complications / Q000378:metabolism; D008875:Middle Aged; D010871:Pinealoma / Q000150:complications / Q000378:metabolism; D010911:Pituitary Neoplasms / Q000150:complications / Q000378:metabolism; D011141:Polyuria / Q000150:complications* / Q000378:metabolism; D012964:Sodium / Q000378:metabolism
chemical_list: D012964:Sodium