Benzodiazepine receptors in "emotional" and "non-emotional" mice; comparison of four strains.
The binding of 3H-diazepam to membrane benzodiazepine receptors was examined in four inbred strains of mice. "Emotional" or "anxious" BALB/cJ mice had significantly lower specific benzodiazepine binding when compared with three other "non-emotional" strains. Scatchard analysis demonstrated that the lower specific benzodiazepine binding is the result of a lower density of receptors in the "emotional" BALB/cJ mice. These results reinforce the contention that a system involving the benzodiazepine receptor may play a role in emotional behavior.
D000818:Animals; D001007:Anxiety / Q000503:physiopathology*; D001923:Brain Chemistry; D003975:Diazepam / Q000378:metabolism*; D006801:Humans; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D011955:Receptors, Drug / Q000378:metabolism*; D013045:Species Specificity
D011955:Receptors, Drug; D003975:Diazepam