[Effect of the external use of triamcinolone acetonide under foil occlussive dressings on the plasma cortisol level and on the diurnal rhythm of plasma cortisol].
Plasma cortisole concentration was measured in 44 patients with chronic dermatitis before, during, and after occlusive treatment with corticosteroid-containing ointment (triamcinolone-acetonide). In all patients plasma cortisole concentration decreased (p less than 0.001) and the day-night-rhythm disappeared. Five patients in whom less than 20% of the body-surface was treated, showed the same but less significant changes in the plasma cortisole concentration. In some patients the plasma coritsole concentrations increased three days after therapy, and their day-night-rhythm returned. This "systemic effect" of topical treatment with triamcinolone-acetonide is not the reason for the therpeutic efficacy, but rather the local concentration of steroids in the skin.
D000287:Administration, Topical; D000328:Adult; D001682:Biological Availability; D002940:Circadian Rhythm; D004305:Dose-Response Relationship, Drug; D004485:Eczema / Q000188:drug therapy; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000037:antagonists & inhibitors / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009779:Occlusive Dressings; D011565:Psoriasis / Q000188:drug therapy; D012869:Skin Absorption; D013997:Time Factors; D014222:Triamcinolone Acetonide / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*
D014222:Triamcinolone Acetonide; D006854:Hydrocortisone
Beeinflussung des Plasmakortisolspiegels und der Plasmakortisoltagesrhythmik durch externe Anwendung von Triamzinolonazetonid unter Folienokklusivverbänden