Pharmacokinetics of trimethoprim (TMP) in normal and febrile rabbits.
The pharmacokinetics of trimethoprim (TMP) were investigated in normal and febrile rabbits. The half-life of TMP in rabbits is about 40 minutes and no differences were found between the half-life in normal and febrile rabbits. A significantly greater volume of distribution of TMP, however, was found in the febrile rabbits. Analysis according to the two-compartment model showed that the differences are due to a change in the distribution of TMP towards the peripheral compartments.
D000818:Animals; D005260:Female; D005334:Fever / Q000378:metabolism*; D006207:Half-Life; D007275:Injections, Intravenous; D008297:Male; D011817:Rabbits; D013997:Time Factors; D014295:Trimethoprim / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*
D014295:Trimethoprim