title: Hypothesis-determinant factors in the manifestations of atopic disease.
abstract: It is postulated that both the initiation and the perpetuation of atopic disease occur as a result of a complex interaction of a genetically determined IgE response, increased permeability of the gastrointestinal and respiratory tracts, and an inherent metabolic instability that may be either localized or generalized. These three factors vary as a function of age and serve to explain the complicated natural history of allergic manifestations in atopic persons.
mesh_terms: D000367:Age Factors; D002463:Cell Membrane Permeability; D004064:Digestive System / Q000276:immunology; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D007073:Immunoglobulin E / Q000032:analysis; D012137:Respiratory System / Q000276:immunology
chemical_list: D007073:Immunoglobulin E