title: The behaviour of fibroblasts migrating from chick heart explants: changes in adhesion, locomotion and growth, and in the distribution of actomyosin and fibronectin.
abstract: Fibroblasts migrating from heart explants of chick embryos at first have a high rate of locomotion but lack focal contacts or adhesions and also lack substantial actin-containing bundles. A meshwork of 7-nm filaments is present particularly in submembranous regions and is proposed to be directed towards efficient locomotion whilst maintaining a high degree of spreading. Also during the first 48 h there is little production of extracellular fibronectin and the growth rate is low. Later, these fibroblasts develop focal contacts and focal adhesions together with actomyosin bundles, with a parallel increase in fibronectin expression. We propose that progressive immobilization by the development of focal adhesions and actomyosin structures occurs to set these cells up for growth.
mesh_terms: D000205:Actomyosin / Q000032:analysis*; D000818:Animals; D002448:Cell Adhesion; D002453:Cell Cycle; D002455:Cell Division; D002462:Cell Membrane / Q000648:ultrastructure; D002465:Cell Movement; D002642:Chick Embryo; D003599:Cytoskeleton / Q000648:ultrastructure; D005347:Fibroblasts; D005353:Fibronectins / Q000032:analysis* / Q000096:biosynthesis; D009206:Myocardium / Q000166:cytology
chemical_list: D005353:Fibronectins; D000205:Actomyosin