Effect of the depletion on brain noradrenaline on the plasma FSH and growth hormone levels in ovariectomized rats.
The electrolytic lesion of locus coeruleus reduced the hypothalamic noradrenaline (NE) content to 28% of the control values and resulted in a marked decrease of the plasma FSH level in ovariectomized rats before puberty. The local microinjection of 6-OH-dopamine into the locus coeruleus led to a reduction in the hypothalamic NE content to 21% of the control level and induced a decrease of the compensatory ovarian hypertrophy and that of the plasma FSH level. The electrolytic lesion of the locus coeruleus or the 6-OH-dopamine treatment failed to influence the plasma growth hormone (GH) level. The observations support the hypothesis that ventral noradrenergic projection is involved in controlling the pituitary FSH secretion.
D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000502:physiology; D002369:Castration; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D013006:Growth Hormone / Q000097:blood*; D006892:Hydroxydopamines / Q000494:pharmacology; D007031:Hypothalamus / Q000378:metabolism; D008125:Locus Coeruleus / Q000502:physiology; D009638:Norepinephrine / Q000378:metabolism* / Q000502:physiology; D051381:Rats
D006892:Hydroxydopamines; D005640:Follicle Stimulating Hormone; D013006:Growth Hormone; D009638:Norepinephrine