Induced PKU in rats: effects of age and melatonin treatment.
Newborn rats injected on Days 1-8 of life with L-phenylalanine (2 g/kg) and p-chlorophenylalanine (80 mg/kg) displayed biochemical symptoms analogous to human phenylketonuria (PKU) and maze learning impairments. The behavioral effects were less evident in rats treated on Days 9-16 or 7-24. None of the symptoms observed were alleviated by simultaneous administration of melatonin (10 mg/kg/day).
D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D005260:Female; D006801:Humans; D007858:Learning / Q000187:drug effects; D008550:Melatonin / Q000494:pharmacology*; D010649:Phenylalanine / Q000097:blood; D010661:Phenylketonurias / Q000139:chemically induced* / Q000503:physiopathology; D011247:Pregnancy; D051381:Rats; D013997:Time Factors; D014443:Tyrosine / Q000097:blood
D014443:Tyrosine; D010649:Phenylalanine; D008550:Melatonin