Increased susceptibility to the epileptic effects of alcohol withdrawal following periodic electroconvulsive shocks.
There was a progressive intensification (kindling) of the motor seizure pattern when electroconvulsive shocks (ECSs) were administered to rats at 3-day intervals, but not when the inter-ECS interval was 1 hr. Similarly, the incidence of convulsive symptoms elicited by subsequent alcohol exposure and withdrawal was a function of the number of antecedent ECSs administered at 3-day, but not at 1-hr, intervals. Significant ECS-produced intensification of the alcohol withdrawal syndrome persisted for 3 weeks following ten periodic ECSs and occurred even when the motor seizures elicited by the antecedent ECSs were pharmacologically suppressed.
D000818:Animals; D001285:Atropine / Q000627:therapeutic use; D001463:Barbiturates / Q000627:therapeutic use; D004597:Electroshock; D006801:Humans; D008297:Male; D051381:Rats; D012640:Seizures / Q000188:drug therapy / Q000209:etiology*; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy / Q000209:etiology*; D013390:Succinylcholine / Q000627:therapeutic use
D001463:Barbiturates; D001285:Atropine; D013390:Succinylcholine