title: 6-Methylpurine-induced inhibition of sclerotia morphogenesis in Sclerotium rolfsii and its reversal by adenosine.
abstract: In liquid synthetic medium inoculated with Sclerotium rolfsii (SR), addition of 6-methylpurine (MP, 50microgram/ml) immediately after inoculation led to approximately 100% reduction in sclerotia production. Adenosine, and to a lesser extent guanosine, each at final concentration of 100microgram/ml significantly reduced inhibition of sclerotia formation by SR in presence of 50microgram/ml MP. Uridine and cytidine each at 100microgram/ml had no such effect. The inhibition of sclerotia morphogenesis could be prevented by addition of 800microgram/ml of adenosine together with 50microgram/ml MP. Reversal by adenosine of MP-induced inhibition of sclerotia development was concentration dependent.
mesh_terms: D000241:Adenosine / Q000494:pharmacology*; D001203:Ascomycota / Q000187:drug effects* / Q000254:growth & development; D003864:Depression, Chemical; D006151:Guanosine / Q000494:pharmacology; D009024:Morphogenesis / Q000187:drug effects; D011687:Purines / Q000494:pharmacology*
chemical_list: D011687:Purines; D006151:Guanosine; D000241:Adenosine