Immunofluorescence study of brain plaques from two patients with multiple sclerosis.
Immunofluorescence studies were performed on selected plaques from two multiple sclerosis patients. Positive staining revealed the corresponding presence of immunoglobulin G and complement fraction C1q within the plaque areas. These components could be removed only after low pH washing. On the basis of these observations, we discuss the possibility of the presence of immunocomplexes within the multiple sclerosis brain.
D001921:Brain / Q000276:immunology*; D003176:Complement C3 / Q000032:analysis; D003181:Complement C4 / Q000032:analysis; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007072:Immunoglobulin D / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008459:Measles virus / Q000276:immunology; D009103:Multiple Sclerosis / Q000276:immunology*
D003176:Complement C3; D003181:Complement C4; D007070:Immunoglobulin A; D007072:Immunoglobulin D; D007075:Immunoglobulin M