Nature of DNA synthesized in the presence of ATP in isolated nuclei.
Optimal DNA synthesis in isolated Ehrlich ascites tumor cell nuclei depends upon the presence of ATP. The increased synthesis in the presence of ATP is shown to be due primarily to increased synthesis per active site rather than initiation of synthesis at different sites. The size of the short pieces observed in the presence of ATP is larger than the corresponding pieces observed in the absence of ATP.
D000255:Adenosine Triphosphate / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D001665:Binding Sites; D001973:Bromodeoxyuridine / Q000378:metabolism; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism*; D002467:Cell Nucleus / Q000378:metabolism; D004260:DNA Repair; D004261:DNA Replication; D004273:DNA, Neoplasm / Q000096:biosynthesis*; D066298:In Vitro Techniques
D004273:DNA, Neoplasm; D000255:Adenosine Triphosphate; D001973:Bromodeoxyuridine