Mixed bacterial and fungal meningitis in a neonate.
Mixed infections of the central nervous system occurring in children without underlying neurological disease may be more frequent than previously suspected. In this case report, a neonate whose cerebrospinal fluid culture at 24 hours showed group B streptococcus only, was found on postmortem examination at six days of age to have disseminated candidiasis with cerebral abscesses. The degree of systemic involvement in this newborn suggested intra-uterine acquired candidiasis. Early diagnosis of polymicrobic infections is difficult, but this case suggests it should be considered in patients not responding to antibiotic therapy.
D001921:Brain / Q000473:pathology*; D001922:Brain Abscess / Q000473:pathology*; D002177:Candidiasis / Q000150:complications* / Q000473:pathology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000473:pathology*; D008297:Male; D008431:Maternal-Fetal Exchange; D008581:Meningitis / Q000473:pathology*; D011247:Pregnancy; D013290:Streptococcal Infections / Q000150:complications* / Q000473:pathology