The effect of environmental lighting on porphyrin hepatic metabolism in the rat.
It has been shown that light may stimulate hepatic porphyria in the rat. This is evidently due to a neuro-endocrine pathway involving retina, nerve pathways in the brain and including the sympathetic chain, the pineal gland and the gonads. This light effect in porphyria appears to be via a circadian rhythm in the liver.
D000624:5-Aminolevulinate Synthetase / Q000378:metabolism; D000818:Animals; D002940:Circadian Rhythm; D003997:Dicarbethoxydihydrocollidine / Q000009:adverse effects; D005260:Female; D006118:Griseofulvin / Q000009:adverse effects; D008027:Light; D008099:Liver / Q000201:enzymology; D008297:Male; D051379:Mice; D009434:Neural Pathways / Q000502:physiology; D010053:Ovary / Q000502:physiology; D010870:Pineal Gland / Q000502:physiology; D011164:Porphyrias / Q000139:chemically induced / Q000201:enzymology; D011166:Porphyrins / Q000378:metabolism*; D051381:Rats; D012160:Retina / Q000502:physiology; D012737:Sex Factors
D011166:Porphyrins; D006118:Griseofulvin; D003997:Dicarbethoxydihydrocollidine; D000624:5-Aminolevulinate Synthetase