Absorption and elimination kinetics of 32P malathion in the hen.
A method for the separation of urine and faeces in the hen was developed and the biological fate of 32P malathion, following a single oral dose of 262.40 mg/kg body weight was studied. The results suggested that the compound was rapidly absorbed from the gastrointestinal tract; significant quantities being detected in the plasma and whole blood 1/2 hr after ingestion. Total 32P was eliminated in the urine by apparent first order kinetics with an average half-life of 5.7 hrs. The cumulative urinary and faecal data revealed that 93% of the 32P is excreted via the urine within 48 hrs, thus indicating that the compound is almost completely absorbed. It is therefore concluded that accumulation in the system is unlikely.
D000284:Administration, Oral; D000818:Animals; D002645:Chickens / Q000378:metabolism*; D005243:Feces / Q000032:analysis; D005260:Female; D006207:Half-Life; D007408:Intestinal Absorption; D008294:Malathion / Q000008:administration & dosage / Q000032:analysis / Q000378:metabolism*; D013997:Time Factors
D008294:Malathion