title: Protective effects of a novel thromboxane analog in lethal traumatic shock.
abstract: Pinane thromboxane A2 (PTA2) an analog of thromboxane A2 that inhibits the formation of thromboxanes as well as antagonizes their biological actions, at an infusion rate of 1.0 mumole . kg-1 . h-1, prolonged survival in traumatic shock in rats. PTA2 also prevented the accumulation of thromboxane B2, the lysosomal protease, cathepsin D, and the cardiotoxic peptide MDF in the circulating blood.
mesh_terms: D000818:Animals; D000081008:Bicyclic Monoterpenes; D002403:Cathepsins / Q000097:blood; D009201:Myocardial Depressant Factor / Q000097:blood; D051381:Rats; D012774:Shock, Traumatic / Q000097:blood / Q000188:drug therapy*; D013928:Thromboxane A2 / Q000031:analogs & derivatives / Q000627:therapeutic use*; D013929:Thromboxane B2 / Q000097:blood; D013931:Thromboxanes / Q000037:antagonists & inhibitors / Q000627:therapeutic use*
chemical_list: D000081008:Bicyclic Monoterpenes; D009201:Myocardial Depressant Factor; D013931:Thromboxanes; D013929:Thromboxane B2; D013928:Thromboxane A2; C020465:pinane-thromboxane A2; D002403:Cathepsins