[Immunologic reactivity of the body and the adrenal cortex function in the early period after administration of a carcinogen].
The level of immunological reactivity and the functional state of the adrenal cortex were studied simultaneously in BALB/c mice 7 days after a single injection of various doses of methylcholanthrene. There existed a definite correlation between the immunodepression induced by various doses of methylcholanthrene determined according to the amount of plaque-forming cells in the experimental mouse spleen and free and combined 11-corticosteroids content in the blood plasma after 7 days of the carcinogen injection. This evidence suggests that the adrenal cortex hormones play a definite role in the pathogenesis of immunodepression induced by chemical carcinogenesis.
D015062:11-Hydroxycorticosteroids / Q000097:blood; D000302:Adrenal Cortex / Q000503:physiopathology*; D000818:Animals; D000921:Antibody-Producing Cells / Q000473:pathology*; D002452:Cell Count / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D007166:Immunosuppressive Agents; D008297:Male; D008748:Methylcholanthrene / Q000008:administration & dosage; D051379:Mice; D013154:Spleen / Q000473:pathology*; D013997:Time Factors
D015062:11-Hydroxycorticosteroids; D007166:Immunosuppressive Agents; D008748:Methylcholanthrene
Immunologicheskaia reaktivnost' organizma i funktsiia kory nadpochechnikov v ranniĭ period khimicheskogo kantserogeneza.