[Effect of polyploidogenic factors on Trichothecium roseum mycelium in the process of trichothecine and fibrinolytic enzyme biosynthesis].
The effect of colchicine and boric acid on the substrate mycelium of Trichothecium roseum was studied in the course of trichothecin biosynthesis. Addition of boric aicd (0.01%) and colchicine (0.1%) to the medium for biosynthesis increased the antibiotic activity of the fungus, this being due to the specific effect of polyploidogenous factors on growth of the mycelium and the proportion of nuclei in it. The number of nuclei increased in cells of the substrate mycelium correlating with a higher antibiotic activity.
D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D001888:Boric Acids / Q000494:pharmacology; D002467:Cell Nucleus / Q000187:drug effects; D003078:Colchicine / Q000494:pharmacology; D003470:Culture Media; D004305:Dose-Response Relationship, Drug; D005342:Fibrinolysis / Q000187:drug effects*; D003904:Mitosporic Fungi / Q000187:drug effects / Q000378:metabolism*; D011123:Polyploidy; D012717:Sesquiterpenes / Q000096:biosynthesis*; D013997:Time Factors; D014255:Trichothecenes / Q000096:biosynthesis*
D000900:Anti-Bacterial Agents; D001888:Boric Acids; D003470:Culture Media; D012717:Sesquiterpenes; D014255:Trichothecenes; D003078:Colchicine
Vliianie poliploidogennykh faktorov na mitseliĭ Trichothecium roseum v protsesse biosinteza trikhotetsina i fibrinoliticheskikh fermentov.