title: Comparative effects of metformin and phenformin on the progression and regression of cholesterol induced athreosclerosis in rabbits.
abstract: This work was undertaken to determine the comparative effects of metformin and phenformin on the development and the regression of atherosclerosis in cholesterol fed rabbits: 1. Both compounds reduced very significantly the elevated lipid content of plasma induced by a high cholesterol diet, they limited and sometimes suppressed the appearance of lipid deposits in the liver. Only metformin prevented the development of aortic and coronary lesions. 2. In rabbits fed a cholesterol enriched diet for a period of 2 months, followed by a normal diet during 12 months, both compounds accelerated the sponanteous regression of hyperlipidemia and of the excess lipids in the liver, observed in the corresponding controls. Only metformin promoted a marked elimination of arterial lipids and displayed a protective action against coronary atherosclerosis.
mesh_terms: D000818:Animals; D001161:Arteriosclerosis / Q000209:etiology / Q000517:prevention & control*; D002791:Cholesterol, Dietary / Q000009:adverse effects*; D005234:Fatty Liver / Q000517:prevention & control; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008687:Metformin / Q000494:pharmacology*; D010629:Phenformin / Q000494:pharmacology*; D011817:Rabbits
chemical_list: D002791:Cholesterol, Dietary; D008687:Metformin; D010629:Phenformin