title: [Biotransformation of rifampicin in pulmonary tuberculosis patients].
abstract: Biotransformation of rifampicin in 39 tuberculosis patients treated with the drug was studied. The studies showed that biotransformation of rifampicin was most intensive during the first 3--6 hours after its use, which was confirmed by excretion of maximum amounts of rifampicin and its metabolites with the urine. 2--4 weeks after the beginning of the treatment with rifampicin excretion of its metabolism products decreased. When rifampicin was used simultaneously in a single dose with tubazid excretion of rifampicin transformation product and desacetylation of the antibiotic slowed down.
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D001711:Biotransformation; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012293:Rifampin / Q000378:metabolism* / Q000627:therapeutic use / Q000652:urine; D013997:Time Factors; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000378:metabolism*
chemical_list: D007538:Isoniazid; D012293:Rifampin
vernacular_title: Biotransformatisiia rifampitsina u bol'nykh tuberkulezom legkikh