Potentiation by clofibrate of in-vivo tumor inhibition by hydrazine sulfate and cytotoxic agents, in Walker 256 carcinosarcoma.
Clofibrate as a sole agent was found to have statistically perceptible antitumor effects against the in vivo growth of Walker 256 intramuscular carcinosarcoma in rats. Clofibrate was also found to potentiate the antitumor effect of hydrazine sulfate, cytotoxic drugs and the combination of hydrazine sulfate + cytotoxic drug. The results suggest that substances which might directly or indirectly interfere with host lipogenesis and/or lipolysis, may also have adjunctal antitumor potential.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002279:Carcinoma 256, Walker / Q000188:drug therapy*; D002994:Clofibrate / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D006834:Hydrazines / Q000627:therapeutic use*; D051381:Rats
D000970:Antineoplastic Agents; D006834:Hydrazines; C029424:hydrazine; D002994:Clofibrate