Influence of treatment duration on audiogenic seizure susceptibility during barbiturate withdrawal in rats.
Barbiturate withdrawal seizure susceptibility in rats increased with increasing duration of treatment during a 15-day treatment period in which the animals were given an i.p. dose of sodium barbital every 12 h. This method of producing dependence has clear advantages over previously described methods.
D000161:Acoustic Stimulation; D000818:Animals; D001463:Barbiturates / Q000009:adverse effects*; D006801:Humans; D008297:Male; D051381:Rats; D012640:Seizures / Q000209:etiology*; D013375:Substance Withdrawal Syndrome / Q000150:complications / Q000503:physiopathology*; D019966:Substance-Related Disorders / Q000150:complications / Q000503:physiopathology; D013997:Time Factors
D001463:Barbiturates