Anticomplementary properties of 043/63 and 043/13 two new antiinflammatory drugs.
The anticomplementary properties of two indandione derivatives were studied in vitro on fresh human serum and in vivo on rabbits. In vitro the two substances block immunohemolysis and have direct effect on serum complement activity. One substance blocks the activation of the first complement component and the other the fourth complement component. In vivo, single doses, lower or block complement activity of rabbit serum.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001969:Bromobenzenes / Q000494:pharmacology; D003165:Complement System Proteins; D004306:Dose-Response Relationship, Immunologic; D006461:Hemolysis; D006801:Humans; D007192:Indenes / Q000494:pharmacology*; D009281:Naphthalenes / Q000494:pharmacology; D011817:Rabbits; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D001969:Bromobenzenes; D007192:Indenes; D009281:Naphthalenes; D003165:Complement System Proteins