On the possible anti-rheumatic effects (immuno-effector?)of imidazole derivatives (levamisole, clotrimazole, niridazole).
Some imidazole derivatives (levamisole, clotrimazole) have no significant effect on the rat adjuvant arthritis at dosages used in human therapy. If the effectiveness of these drugs in rheumatoid arthritis is confirmed by double blind studies, it would be necessary to find an explanation other than an immuno-effective action does not occur in some patients.
D000818:Animals; D001168:Arthritis / Q000188:drug therapy*; D001169:Arthritis, Experimental / Q000188:drug therapy*; D007093:Imidazoles / Q000627:therapeutic use*; D007978:Levamisole / Q000627:therapeutic use; D008297:Male; D009560:Niridazole / Q000627:therapeutic use; D051381:Rats; D013773:Tetramisole / Q000627:therapeutic use
D007093:Imidazoles; D007978:Levamisole; D013773:Tetramisole; D009560:Niridazole