title: Effect of stimulation of locus coeruleus on the evoked potential in the amygdala in rats.
abstract: Effects of stimulation of the locus coeruleus (LC) on evoked potential in the medial amygdala elicited by stimulation of the olfactory bulb (OB-AME potentials) were studied in the gallamine-immobilized rats. The amplitude of the OB-AME potential was inhibited 27.5% by the conditioning stimulation of LC delivered 30 msec before the test stimulation. The inhibitory effect of LC was reduced by propranolol 5 mg/kg i.p., but not by phentolamine 10 mg/kg i.p.. This effect was also reduced by tetrabenazine 10 mg/kg i.p.. Methamphetamine 5 mg/kg i.p. produced considerable potentiation of the LC inhibitory effect and a reduction of the OB-AME potential itself. These results suggest that the LC plays an inhibitory role in the electrical activity of the medial amygdala.
mesh_terms: D000679:Amygdala / Q000502:physiology*; D000818:Animals; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects; D006801:Humans; D008125:Locus Coeruleus / Q000502:physiology*; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology; D009830:Olfactory Bulb / Q000502:physiology; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D013747:Tetrabenazine / Q000494:pharmacology
chemical_list: D008694:Methamphetamine; D011433:Propranolol; D010646:Phentolamine; D013747:Tetrabenazine