title: [Study in vitro of the biosynthesis of Hb in alpha-thalassemic subjects of Puglia].
abstract: An haematological study and haemoglobin biosynthesis in vitro carried out on the members of family from Ostuni (Apulia), three of which present Hb H in quantities varying from 26 to 28 and 29%, has been reported. On the basis of the haematological and biosynthetical data, the Authors think that the genetics of the alpha-thalassemia in the family under observation is similar to that observed in South East Asia according to the hypothesis of the existence of two alpha loci. The biosynthetical data fall into the values obtained by Kan and Coll. even if with slight differences.
mesh_terms: D006455:Hemoglobins, Abnormal / Q000032:analysis*; D006801:Humans; D007558:Italy; D013789:Thalassemia / Q000097:blood* / Q000453:epidemiology / Q000235:genetics
chemical_list: D006455:Hemoglobins, Abnormal
vernacular_title: Studio in vitro della biosintesi della Hb in soggetti pugliesi alpha talassemici.