Normal pressure hydrocephalus, parkinsonism, and primary empty sella--coincidence or cause-effect?
The triad of normal-pressure hydrocephalus, parkinsonism, and primary empty sella appeared in a 70-year-old woman. There was dramatic resolution of the extrapyramidal signs and symptoms on treatment with levodopa-carbidopa and ventriculojugular shunt. The syndrome may be the result of several mechanisms, but an alteration of cerebrospinal fluid (CSF) pressure dynamics may be the sole etiology for this triad.
D000368:Aged; D002230:Carbidopa / Q000008:administration & dosage; D002557:Cerebrospinal Fluid Shunts; D004359:Drug Therapy, Combination; D004652:Empty Sella Syndrome / Q000150:complications*; D005260:Female; D006801:Humans; D006849:Hydrocephalus / Q000150:complications*; D006850:Hydrocephalus, Normal Pressure / Q000150:complications* / Q000601:surgery; D007601:Jugular Veins; D007980:Levodopa / Q000008:administration & dosage; D010300:Parkinson Disease / Q000150:complications* / Q000188:drug therapy
D007980:Levodopa; D002230:Carbidopa