Development of hemangiosarcomas in B6C3F1 mice fed 2-methyl-1-nitroanthraquinone.
Subcutaneous hemangiosarcomas developed in 97% of 172 B6C3F1 mice of both sexes fed either 0.03% or 0.36% 2-methyl-1-nitroanthraquinone in the diet. There was no significant relationship to dose or sex. In addition similar vascular tumors occurred in the mesentery of 14 mice. 2-Methyl-1-nitroanthraquinone is carcinogenic in B6C3F1 mice when given in food. One of 97 control mice had a splenic hemangiosarcoma.
D000818:Animals; D000880:Anthraquinones / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D005260:Female; D006394:Hemangiosarcoma / Q000139:chemically induced* / Q000473:pathology; D008175:Lung Neoplasms / Q000473:pathology; D008297:Male; D008643:Mesentery / Q000473:pathology; D051379:Mice; D008815:Mice, Inbred Strains; D009132:Muscles / Q000473:pathology; D009362:Neoplasm Metastasis; D012737:Sex Factors
D000880:Anthraquinones; C016581:2-methyl-1-nitroanthraquinone