title: Fc receptors for human, rabbit and pig antibodies on human eosinophils from normal persons and patients with atopic dermatitis.
abstract: The presence of Fc receptors on eosinophils from normal persons and atopic patients was investigated using a rosetting technique. Normal eosinophils were found to react with pig antibody (32.5% rosettes), rabbit antibody (46,6% rosettes) and human antibody (29.3% rosettes). Eosinophils from atopic dermatitis patients also formed rosettes with these antibodies, but the percentage of rosettes with pig antibody was significantly higher (63,5%; p less than 0.001) than that given by normal eosinophils. A similar result was found with eosinophils from patients with other atopic diseases (asthma and hay fever) suggesting a similar pattern of eosinophil alteration in all atopic patients. On the other hand, eosinophils from patients with non-atopic eczemas did not differ from those of normals.
mesh_terms: D000328:Adult; D000818:Animals; D000906:Antibodies; D001249:Asthma / Q000276:immunology; D001665:Binding Sites; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000097:blood / Q000276:immunology*; D004485:Eczema / Q000276:immunology; D004804:Eosinophils / Q000276:immunology*; D006801:Humans; D007141:Immunoglobulin Fc Fragments; D008875:Middle Aged; D011817:Rabbits; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology; D012397:Rosette Formation; D013552:Swine
chemical_list: D000906:Antibodies; D007141:Immunoglobulin Fc Fragments