In vivo effect of UV-B on lymphocyte function.
Whole-body exposure of normal subjects to erythemogenic doses of UV-B radiation results in a decrease in the proportion of circulating E-rosette-forming lymphocytes, an increase in the proportion of null cells and a decreased incorporation of tritiated thymidine into DNA of lymphocytes following stimulation by phytohaemagglutinin (PHA). These alterations are dose-dependent, appear soon after exposure, reach a maximum after 8-12 h, and are reversed by 48-72 h post exposure.
D000328:Adult; D002940:Circadian Rhythm; D004307:Dose-Response Relationship, Radiation; D004890:Erythema / Q000209:etiology / Q000276:immunology; D006801:Humans; D007958:Leukocyte Count; D008214:Lymphocytes / Q000378:metabolism / Q000528:radiation effects*; D010835:Phytohemagglutinins / Q000494:pharmacology; D012397:Rosette Formation; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors; D014466:Ultraviolet Rays
D010835:Phytohemagglutinins; D013936:Thymidine