3H-etorphine levels in CNS of tolerant and non-tolerant rats.
Rats were rendered tolerant to etorphine by administering it daily for 5 days at doses of either 10 microgram/kg i.v. or 5 microgram/kg s.c..3H-etorphine was then injected to tolerant and non-tolerant rats; after 15 min their brain and spinal cord were removed for 3H-etorphine assay. Tolerant rats had lower 3H-etorphine levels in both tissues than control rats.
D000818:Animals; D001921:Brain / Q000378:metabolism; D002389:Catatonia / Q000139:chemically induced; D002490:Central Nervous System / Q000378:metabolism*; D004361:Drug Tolerance; D005048:Etorphine / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans; D008297:Male; D009019:Morphinans / Q000378:metabolism*; D004856:Postural Balance / Q000187:drug effects; D051381:Rats; D013116:Spinal Cord / Q000378:metabolism
D009019:Morphinans; D005048:Etorphine