title: Failure of signs of physical dependence to develop in hamsters after prolonged consumption of large doses of ethanol.
abstract: Male Golden Hamsters drank large amounts of ethanol with food and water freely available, when ethanol was presented in water at concentrations of 10-40% (w/v). Although the hamsters consumed an average of 13.8 g/kg/day of ethanol for 3 months, no withdrawal signs were observed during 4 days without ethanol, nor were withdrawal signs observed during withdrawal after 4 more months of ethanol consumption. Although the Golden Hamster consumes large amounts of ethanol without the need for food or water deprivation, the Golden Hamsters may have limited usefulness as a model of physical dependence.
mesh_terms: D000161:Acoustic Stimulation; D000428:Alcohol Drinking; D000437:Alcoholism / Q000150:complications / Q000503:physiopathology*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002755:Choice Behavior; D006224:Cricetinae; D000431:Ethanol / Q000494:pharmacology; D006801:Humans; D008297:Male; D008647:Mesocricetus; D012640:Seizures / Q000209:etiology / Q000503:physiopathology; D013375:Substance Withdrawal Syndrome / Q000209:etiology / Q000503:physiopathology; D013997:Time Factors
chemical_list: D000431:Ethanol