[Microfilaricidal action of Diethylcarbamazine on Dipetalonema dessetae in his natural host (author's transl)].
With a Filaria of Rodent whose microfilariae are periodic and diurnal, and destroyed by DEC, the authors don't observe the immediate rise of microfilaria count sometimes noted following treatment of periodic filaria during the low phase of microfilaremia. Moreover, the microfilaremia falls at 30% of the pre-treatment level after 15 mn. This may be in relation with the swift digestive absorption, as detected by the rise of the DEC serum level, whose maximum is reached within 15 mn.
D000818:Animals; D002940:Circadian Rhythm; D004049:Diethylcarbamazine / Q000097:blood / Q000494:pharmacology*; D005260:Female; D005370:Filarioidea / Q000187:drug effects*; D008297:Male; D008842:Microfilariae / Q000187:drug effects; D012377:Rodentia / Q000469:parasitology*
D004049:Diethylcarbamazine
Action de la diéthylcarbamazine sur les microfilaires de Dipetalonema dessetae chez son hôte définitif.