Aplysinopsin: antineoplastic tryptophan derivative from the marine sponge Verongia spengelii.
Bioassay-guided fractionation of the aqueous alcoholic extract of the marine sponge Verongia spengelii for tumor inhibitory agents led to the isolation of aplysinopsin, a new tryptophan derivative recently reported from another sponge Thorecta aplysinopsis. Aplysinopsin showed cytotoxicity against the KB, P388 and L1210 cell cultures.
D000818:Animals; D000970:Antineoplastic Agents; D002460:Cell Line; D003603:Cytotoxins; D007939:Leukemia L1210; D011161:Porifera / Q000032:analysis*; D014364:Tryptophan / Q000031:analogs & derivatives* / Q000302:isolation & purification
D000970:Antineoplastic Agents; D003603:Cytotoxins; C015685:aplysinopsin; D014364:Tryptophan