title: Interaction of hyperoxia and blood flow during fatigue of canine skeletal muscle in situ.
abstract: Right and left gastrocnemius-plantaris muscle preparations in 20 dogs anesthetized with pentobarbital sodium were used to investigate the effect of hyperoxia on tension maintenance. Muscles were stimulated via the sciatic nerve for 20 min at 60 200-ms tetanic contractions/min (10 impulses/contraction). Direct muscle stimulation after the experimental period resulted in no significant change in tension. In control experiments the tension developed by the right or left muscles over the 20 min was not different. The tension developed by muscles perfused with hyperoxic blood decreased 14% after 20 min, whereas tension in the normoxic muscles decreased 35%. Blood flow in the hyperoxic muscles was significantly higher at 20 min (P less than 0.05). Pump perfusion of one of a pair of normoxic muscles resulted in a tension decrease of 13% in the pump-perfused muscles, whereas tension in the control muscles decreased 34%. Tension maintenance was flow dependent. The effect of hyperoxia could be mediated through the involvement of oxygen in the long-term control of muscle blood flow.
mesh_terms: D000818:Animals; D001794:Blood Pressure; D004285:Dogs; D005260:Female; D008297:Male; D009119:Muscle Contraction; D009129:Muscle Tonus; D009132:Muscles / Q000098:blood supply / Q000502:physiology*; D010100:Oxygen / Q000097:blood*; D012039:Regional Blood Flow; D012119:Respiration; D013997:Time Factors
chemical_list: D010100:Oxygen