title: Bovine superoxide dismutase and copper ions potentiate the bactericidal effect of autoxidizing cysteine.
abstract: When cysteine is oxidized by oxygen, hydrogen peroxide is formed, and hydrogen peroxide is very toxic to Peptostreptococcus anaerobius VPI 4330-1. Native and inactivated superoxide dismutase increased the rate of oxidation of cysteine and thereby potentiated the toxic effect of cysteine. A similar increase in the rate of oxidation of cysteine and in the toxicity of cysteine was obtained with Cu2+.
mesh_terms: D000332:Aerobiosis; D000818:Animals; D002417:Cattle; D003300:Copper / Q000494:pharmacology*; D003545:Cysteine / Q000378:metabolism*; D006861:Hydrogen Peroxide / Q000378:metabolism / Q000494:pharmacology*; D010084:Oxidation-Reduction; D010462:Peptostreptococcus / Q000187:drug effects*; D013482:Superoxide Dismutase / Q000494:pharmacology*
chemical_list: D003300:Copper; D006861:Hydrogen Peroxide; D013482:Superoxide Dismutase; D003545:Cysteine