Transplantable thyroid tumour in rats: iodoamino acid distribution in successive tumour generations.
All first generation thyroid tumours in rats, produced by 3 micronc 131I followed by LID, were uniformly functional containing MIT, DIT, T4, T3, and in some cases, T'3. All fourth generation tumours were nonfunctional as tested. Second and third generation tumours were biochemically unpredictable, some containing all IAA including T'3, others only MIT, I-and a trace DIT. Degree of dedifferentiation and of autonomy did not necessarily correlate with loss of function. Results could be explained by postulating nodules with differing biochemical properties within individual tumours.
D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D004105:Diiodotyrosine / Q000378:metabolism; D005260:Female; D007457:Iodine Radioisotopes; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000378:metabolism; D051381:Rats; D013963:Thyroid Hormones / Q000378:metabolism*; D013964:Thyroid Neoplasms / Q000378:metabolism*; D013974:Thyroxine / Q000378:metabolism; D013997:Time Factors; D014284:Triiodothyronine / Q000378:metabolism; D014443:Tyrosine / Q000378:metabolism
D000596:Amino Acids; D007457:Iodine Radioisotopes; D013963:Thyroid Hormones; D014284:Triiodothyronine; D014443:Tyrosine; D004105:Diiodotyrosine; D013974:Thyroxine