Centromere inactivation in a case of Turner variant with two dicentric iso-long arm Y chromosomes.
A 6-year-old girl of small stature and with some features of Turner's syndrome was found to have a karyotype with two-thirds of the cells possessing one, and one-third with two dicentric iso-long arm Y chromosomes. In metaphases with 46 chromosomes the majority of the abnormal Ys exhibited two primary constrictions. In cells with 47 chromosomes both isochromosomes prevalently had only one active centromere.
D002503:Centromere; D002648:Child; D002875:Chromosomes; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D008677:Metaphase; D012730:Sex Chromosomes; D014424:Turner Syndrome / Q000473:pathology*; D014998:Y Chromosome