title: Heparinised clotting factor concentrates in patients with Christmas disease and liver disease.
abstract: Evidence has been sought of activation of the coagulation system in two groups of patients following the infusion of two heparinised clotting factor concentrates. No changes were detected in 13 patients with mild hepatic dysfunction. In six studies on patients with Christmas disease induced abnormalities occurred in only one. Activation of the coagulation mechanism did not occur in another individual who had received the same batch of material.
mesh_terms: D001772:Blood Cell Count; D001777:Blood Coagulation; D001779:Blood Coagulation Factors / Q000627:therapeutic use*; D001792:Blood Platelets; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D002836:Hemophilia B / Q000097:blood / Q000628:therapy*; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D008107:Liver Diseases / Q000097:blood / Q000628:therapy*; D011517:Prothrombin Time
chemical_list: D001779:Blood Coagulation Factors; D005338:Fibrin Fibrinogen Degradation Products; D006493:Heparin