title: [Energy metabolism study of Fusidium coccineum strains with varying levels of antibiotic formation].
abstract: Energy parameters of the two strains of the inperfect fungus Fusidium coccineum with different levels of antibiotic production were studied comparatively. It was shown that the respiration activity of the both strains was almost completely suppressed by KCN+ salycyl hydroxomate. It provided a supposition that the respiration activity was almost selectively connected with the mitochondria. The analysis of the energy parameters and especially the efficiency of the substrate consumption indicated that the system of oxidative phospholiration was dominant in the energy supply in both the strains. The differences between the strains were observed in the growth rate and the level of KCN-stable respiration. A change in the respiration of the active strain to the alternative KCN-stable path was observed by the end of the 6-8 day fermentation process when significant amounts of fusidin accumulated in the fermentation broth. Correlation between the level of KCN-stability and the antibiotic production was found.
mesh_terms: D003470:Culture Media; D003486:Cyanides / Q000494:pharmacology; D004734:Energy Metabolism / Q000187:drug effects; D005672:Fusidic Acid / Q000096:biosynthesis* / Q000494:pharmacology; D003904:Mitosporic Fungi / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects; D012457:Salicylamides / Q000494:pharmacology
chemical_list: D003470:Culture Media; D003486:Cyanides; D012457:Salicylamides; D005672:Fusidic Acid
vernacular_title: Izuchenie énergeticheskogo obmena shtammov Fusidium coccineum s razlichnym urovnem antibiotikoobrazovaniia.