Methotrexate analogues. 11. Unambiguous chemical synthesis and in vitro biological evaluation of alpha- and gamma-monoesters as potential prodrugs.
D000818:Animals; D001711:Biotransformation; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004950:Esterases / Q000097:blood; D004951:Esterification; D005493:Folic Acid Antagonists; D006801:Humans; D066298:In Vitro Techniques; D007536:Isomerism; D007942:Leukemia, Experimental / Q000473:pathology; D008727:Methotrexate / Q000031:analogs & derivatives* / Q000097:blood / Q000138:chemical synthesis / Q000494:pharmacology; D013045:Species Specificity
D005493:Folic Acid Antagonists; D004950:Esterases; D008727:Methotrexate