Plasma prolactin in juvenile diabetics. 24-h studies with somatostatin.
In normal subjects during 24-hours saline infusion, plasma prolactin showed a number of small rises during day and night. The mean night-time level was significantly higher than the day-time level (8.2 +/- 0.6 ng/ml as against 4.7 +/- 0.5 ng/ml). In 12 insulin-dependent diabetics the 24 h plasma prolactin pattern was identical to that found in normals. Somatostatin infusion (4 mg/24 h in normals; 2--6 mg/24 h in diabetics) had no effect on the 24 h plasma prolactin pattern in either normals or in diabetics.
D000328:Adult; D002940:Circadian Rhythm; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D006801:Humans; D008297:Male; D011388:Prolactin / Q000097:blood*; D013004:Somatostatin / Q000494:pharmacology
D013004:Somatostatin; D011388:Prolactin