The phosphoglucomutase group system of human erythrocytes.
Frequency of PGM1 phenotypes and their corresponding genes in the Polish population was determined in two samples: in 760 adults and 240 children. The frequency of the PGM1 1 gene in adults was 0-748, and in children 0-765. A statistically significant deficiency of heterozygotes was found in adults. Heredity of the phosphoglucomutase system was studied in 52 families with 162 children, in 223 mother-child pairs, and in 73 twin pairs of the same sex. In all groups, phenotypes of PGM1 agreed with the hypothesis of heredity, assuming a pair of alleles of the PGM1 system. In the parent combinations PGM1 1-1 X PGM1 2-1 a deficiency of PGM1 2-1 children was found. Analysis of linkage of genes of the PGM1 system with eight group systems provided data indicating a possibility of linkage of the PGM1 system with the Rh system. The theoretical usefulness of the PGM1 system in paternity investigations in the Polish population was estimated to be 14-24%.
D000328:Adult; D000483:Alleles; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D005554:Forensic Medicine; D005787:Gene Frequency; D008040:Genetic Linkage; D006579:Heterozygote; D006801:Humans; D007223:Infant; D008297:Male; D010334:Paternity; D010641:Phenotype; D010733:Phosphoglucomutase / Q000378:metabolism*; D011044:Poland; D011247:Pregnancy; D014427:Twins
D010733:Phosphoglucomutase