Differentiation of lymphocytes in cerebrospinal fluid in disorders of the central nervous system.
In 73 patients with variable CNS-disorders Slg-lymphocytes and RF-lymphocytes originating from CF were characterized by demonstration of surface markers. In the CF the Slg-lymphocytes were increased in comparison to the blood whereas the RF-lymphocytes generelly were decreased. Patients suffering from acute or chronic inflammatory diseases had significantly more Slg-lymphocytes while RF-lymphocytes were significantly decreased in those patients as well as in patients with malignancies. A correlation between the number of Slg-lymphocytes and immunoglobulin-levels was not seen. The respective data in blood did not follow the changes in CF. The results suggest a prevailing stimulation of the humoral immune system of the CNS during inflammatory diseases.
D000208:Acute Disease; D000818:Animals; D001932:Brain Neoplasms / Q000134:cerebrospinal fluid / Q000276:immunology; D002493:Central Nervous System Diseases / Q000097:blood / Q000134:cerebrospinal fluid*; D002555:Cerebrospinal Fluid / Q000166:cytology*; D002556:Cerebrospinal Fluid Proteins; D002908:Chronic Disease; D004660:Encephalitis / Q000134:cerebrospinal fluid / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology; D006801:Humans; D007104:Immune Adherence Reaction; D007070:Immunoglobulin A / Q000134:cerebrospinal fluid; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid; D007075:Immunoglobulin M / Q000134:cerebrospinal fluid; D008214:Lymphocytes / Q000166:cytology* / Q000276:immunology; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid / Q000276:immunology; D012756:Sheep / Q000276:immunology; D013499:Surface Properties
D002556:Cerebrospinal Fluid Proteins; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M