Effect of chronic administration and withdrawal of sodium barbitone on protein synthesis of rat brain.
After chronic administration of sodium barbitone to rats, a marked increase incorporation of [14C]-Leucine into isolated nerve endings was observed. Withdrawal of the drug resulted in a decreased incorporation with respect to values obtained with chronic ingesting animals. On the other hand chronic administration of the barbiturate produced a decreased incorporation in mitochondrial and microsomal fractions. These results are discussed in relation to the development of tolerance and abstinence syndrome to this drug.
D000818:Animals; D001462:Barbital / Q000494:pharmacology*; D001463:Barbiturates / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects*; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D007930:Leucine / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D051381:Rats; D013375:Substance Withdrawal Syndrome / Q000378:metabolism*
D001463:Barbiturates; D009419:Nerve Tissue Proteins; D001462:Barbital; D007930:Leucine