Cerebral necrosis following irradiation and chemotherapy for metastatic choriocarcinoma.
A case of cerebral necrosis following radiation and chemotherapy in a patient with metastatic cerebral choriocarcinoma is reported. Computed tomography (EMI Scan) demonstrated evolution and enlargement of the necrotic lesion. This focus was surgically excised and histology is presented. The possible enhancement of radiation necrosis by chemotherapy is noted, but the continued need for simultaneous use of radiation and chemotherapy is recognized and discussed.
D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001921:Brain / Q000473:pathology; D001927:Brain Diseases / Q000175:diagnosis / Q000209:etiology*; D001932:Brain Neoplasms / Q000628:therapy*; D002699:Chlorambucil / Q000009:adverse effects; D002822:Choriocarcinoma / Q000628:therapy*; D003609:Dactinomycin / Q000009:adverse effects; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000009:adverse effects; D009336:Necrosis; D009362:Neoplasm Metastasis; D011247:Pregnancy; D011832:Radiation Injuries / Q000175:diagnosis / Q000473:pathology; D011878:Radiotherapy / Q000009:adverse effects*; D014057:Tomography, X-Ray Computed; D014594:Uterine Neoplasms / Q000628:therapy*
D000970:Antineoplastic Agents; D002699:Chlorambucil; D003609:Dactinomycin; D008727:Methotrexate