Electron microscopic studies of circular DNA in mouse embryo fibroblasts infected by Rauscher leukemia virus.
Using electron microscopy, a closed circular form of DNA (4.3 mum in contour length) was detected in the nucleus of mouse embryo fibroblasts 2.5 h after infection by Rauscher murine leukemia virus. These circles were distinguishable from mitochondrial DNA by various criteria, including size, absence of secondary features, and resistance to EcoRI endonuclease.
D000818:Animals; D002467:Cell Nucleus / Q000032:analysis; D046508:Culture Techniques; D004270:DNA, Circular / Q000032:analysis*; D004272:DNA, Mitochondrial / Q000032:analysis; D004279:DNA, Viral / Q000032:analysis*; D005347:Fibroblasts; D051379:Mice; D008854:Microscopy, Electron; D011925:Rauscher Virus / Q000032:analysis* / Q000254:growth & development
D004270:DNA, Circular; D004272:DNA, Mitochondrial; D004279:DNA, Viral