[Psychotropic effect of Elroquil].
The psychotropic effect of Elroquil has been studied in 13 cats (8 of them having electrodes implanted in the hypothalamus). Diazepam was used as the reference drug. By electrical stimulation of the brain structures various states of excitation, such as rage, anxiety, restlessness and negation could be provoked. Evaluation was made by a scoring scale and multivector analysis. When administered in doses of 15--20 mg/kg, Elroquil had a reliable tranquilizing effect, without any negation occurring. Only in doses of 40 mg/kg had aggressiveness and rage to be subdued. However, a neurosis-like condition could not be managed. Characteristically, Elroquil neither changed the group behavior of the animals, nor eliminated conflict situations. Ataxia was not stimulated. The vegetative correlation of emotional strain was changed in length but not in intensity.
D000374:Aggression / Q000187:drug effects; D000818:Animals; D001007:Anxiety / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D002415:Cats; D002746:Chlorpromazine / Q000031:analogs & derivatives* / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D004558:Electric Stimulation; D006801:Humans; D007031:Hypothalamus / Q000187:drug effects / Q000502:physiology*
D003975:Diazepam; D002746:Chlorpromazine
Experimentelle Untersuchungen über Besonderheiten der psychotropen Wirkung von Elroquil.