[Interaction of 3-[3H]-2-n-nonyl-4-hydroxy-quinoline-N-oxide with submitochondrial particles of beef heart. I. Inhibition of the respiratory activity].
The inhibitory effect of 3-3H-2-n-nonyl-4-hydroxy-quinoline-N-oxide (3H-NQNO) on the respiration induced by NADH or by succinate was studied in submitochondrial particles from beef heart. Polarographic experiments showed that oxygen uptake by submitochondrial particles was inhibited by 3H-NQNO. Similar results were obtained with the unlabelled compound NQNO. The inhibitory activity of 3H-NQNO on the respiration was 2 or 3 times better than that of the heptyl derivatives (HQNO) and additive with that shown by antimycin.
D000818:Animals; D002417:Cattle; D006912:Hydroxyquinolines / Q000494:pharmacology*; D066298:In Vitro Techniques; D008929:Mitochondria, Heart / Q000187:drug effects* / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects; D013347:Subcellular Fractions / Q000187:drug effects
D006912:Hydroxyquinolines
Interazione di 3-[3H]-2-N-Nonil-4-idrossi-chinolina-N-ossido con particelle submitocondriali di cuore di bue: 1. Inibizione dell'attivita' respiratoria.