[Absorption and distribution of cytoplasmic organ lysates (conjunctisan A eye drops) following intraconjunctival application (author's transl)].
The absorption and transport pathways of Conjunctisan A were determined, and its mode of action clarified, by means of radioactive labeling. A dose of 0.5 ml of this drug, labeled with I131, was applied to the conjunctival sacs of rats and rabbits. After six hours there was highly significant enrichment in the ocular tissues. The highest degree of enrichment was found in the uvea, i.e., the ciliary body, choroid and retina. However, there was also moderate enrichment in the lens and the vitreous. It was proved immunologically that the radioactivity was identical with the original Conjunctisan A molecule. In particular, it as demonstrated that the enriched Conjunctisan A in the aqueous humor precipitates with the specific antibody.
D000042:Absorption; D000818:Animals; D003228:Conjunctiva / Q000378:metabolism*; D004338:Drug Combinations / Q000378:metabolism; D005136:Eye Proteins; D005260:Female; D008297:Male; D009883:Ophthalmic Solutions; D011233:Precipitin Tests; D011506:Proteins / Q000378:metabolism*; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D014020:Tissue Extracts / Q000378:metabolism*
D004338:Drug Combinations; D005136:Eye Proteins; D009883:Ophthalmic Solutions; D011506:Proteins; D014020:Tissue Extracts; C027144:conjunctisan A
Resorption und Verteilung zytoplasmatischer Organlysate (Conjunctisan A Augentropfen) nach intrakonjunktivaler Applikation.