Bone mineralization and bone mineral content in primary hyperparathyroidism.
The degree of bone mineralization and the bone mineral content (BMC) was evaluated in 6 patients with primary hyperparathyroidism. The degree of bone mineralization was estimated as the phosphorus/hydroxyproline ratio (P/Hypro) in bone biopsies; BMC was estimated by photon absorptiometry on both forearms. The mena values of both parameters were significantly lower than normal (P less than 0.001 for P/Hypro; P less than 0.02 for BMC). As no significant correlation was found between P/Hypro and BMC in hyperparathyroidism, the findings of low values of P/Hypro and of BMC in patients with elevated serum calcium point to primary hyperparathyroidism.
D000328:Adult; D000368:Aged; D001842:Bone and Bones / Q000032:analysis / Q000378:metabolism*; D002118:Calcium / Q000097:blood; D005260:Female; D006801:Humans; D006909:Hydroxyproline / Q000032:analysis / Q000378:metabolism; D006961:Hyperparathyroidism / Q000097:blood / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D008903:Minerals / Q000378:metabolism*; D010281:Parathyroid Hormone / Q000097:blood; D010758:Phosphorus / Q000032:analysis / Q000378:metabolism
D008903:Minerals; D010281:Parathyroid Hormone; D010758:Phosphorus; D006909:Hydroxyproline; D002118:Calcium