Effect of macrophage activation by immunoadjuvants on serum levels of lysosomal hydrolases in mice.
The effect of pyran copolymer, injected into mice bearing the M109 Madison lung carcinoma, on serum concentrations of lysozyme, beta-glucuronidase, and N-acetyl-beta, D-glucosaminidase was studied and compared with that of other immunoadjuvants. Increases in lysozyme levels ranging from 50 to 100% were observed after injection of pyran, BCG and Bru-Pel; increases in the levels of the other enzymes were less consistent. Other immunoadjuvants were less effective in raising serum concentrations of lysosomal enzymes. The findings were correlated with the results of previous studies on macrophage activation and antineoplastic action produced by these immunoadjuvants and suggest that serum levels of lysozyme can serve as indices of these effects.
D000118:Acetylglucosaminidase / Q000097:blood; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D005966:Glucuronidase / Q000097:blood; D006867:Hydrolases / Q000097:blood*; D008247:Lysosomes / Q000201:enzymology*; D008264:Macrophages / Q000187:drug effects*; D008297:Male; D051379:Mice; D009113:Muramidase / Q000097:blood; D009374:Neoplasms, Experimental / Q000201:enzymology; D012673:Semustine / Q000494:pharmacology
D000276:Adjuvants, Immunologic; D012673:Semustine; D006867:Hydrolases; D009113:Muramidase; D005966:Glucuronidase; D000118:Acetylglucosaminidase