Large Y chromosome (Yq+) and increased risk of abortion.
Previous reports have indicated an association between Yq+ in the family and increased risk of abortion. In a chromosome investigations of 11,148 consecutively newborn children, we found 58 boys with a large Y chromosome (Y/F equal to or greater than 1.00). The mothers of these boys had 22% abortions, compared with 13% among 4,895 mothers of children with normal karyotypes and without Yq+ (P less than 0.001).
D000022:Abortion, Spontaneous / Q000453:epidemiology / Q000235:genetics*; D003718:Denmark; D005260:Female; D006801:Humans; D008297:Male; D011247:Pregnancy; D012730:Sex Chromosomes / Q000648:ultrastructure*; D014998:Y Chromosome / Q000648:ultrastructure*