Adhesion and aggregation of human platelets to rabbit subendothelium. A new approach for investigation: specific antibodies.
An SgG antibody occurring in a recently transfused thrombasthenic patient inhibited all the ADP-mediated aggregations and platelet-platelet interaction (thrombus formation) on rabbit aorta subendothelium; another IgG antibody occurring in a multitransfused Bernard-Soulier patient inhibited ristocetin and bovine factor VIII mediated aggregation and platelet-subendothelium interaction.
D000818:Animals; D000906:Antibodies; D000918:Antibody Specificity; D001778:Blood Coagulation Disorders / Q000276:immunology / Q000503:physiopathology; D001791:Blood Platelet Disorders / Q000276:immunology / Q000503:physiopathology; D001792:Blood Platelets / Q000276:immunology; D004727:Endothelium / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D010973:Platelet Adhesiveness; D010974:Platelet Aggregation; D011817:Rabbits / Q000276:immunology
D000906:Antibodies; D007074:Immunoglobulin G