The influence of the nictitating membrane on steroid inhibition of limbal wound healing.
In a study involving 34 rabbits, it was found that local corticosteroids inhibit limbal wound healing in normal rabbit eyes, and do not inhibit similar wounds if the nictitating membrane has been removed. It was further found that the contact time of fluorescein labelled corticosteroids is almost 3 times longer in rabbit eyes with nictitating membranes than those in which the membranes have been removed.
D000287:Administration, Topical; D000818:Animals; D003907:Dexamethasone / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005456:Fluorescent Dyes; D008032:Limbic System / Q000502:physiology*; D008297:Male; D009541:Nictitating Membrane / Q000502:physiology*; D011817:Rabbits; D013718:Tensile Strength; D014945:Wound Healing / Q000187:drug effects*
D005456:Fluorescent Dyes; D003907:Dexamethasone