Effect of brefeldin A and actinomycin D on culture growth and brefeldin A yield in Curvularia lunata.
Cultures incorporated with increasing quantities of brefeldin A in the form of crude extracts of fungal metabolites prior to inoculation demonstrated reduced growth rate and no significant increase in brefeldin A content. On the other hand, cultures incubated with increasing levels of actinomycin D on the 8th day of cultivation showed slight stimulation of brefeldin A formation with insignificant effect on growth.
D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000494:pharmacology; D003517:Cyclopentanes / Q000096:biosynthesis / Q000494:pharmacology; D003609:Dactinomycin / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism; D003904:Mitosporic Fungi / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D009183:Mycotoxins / Q000096:biosynthesis / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D003517:Cyclopentanes; D009183:Mycotoxins; D003609:Dactinomycin; D005947:Glucose