[Effect of substances of a polypeptide nature isolated from the cerebral cortex on the immune response of mice].
The influence of low molecular weight polypeptides (Mol wt below 10,000) isolated by acetic acid extraction from the cortex and white matter of the brain and from the bone marrow of cows on the primary immune response to SRBC was studied in experiments on 248 male CBA mice. The results showed that after the subcutaneous injections of the preparations from the cortex (where the theta-antigen cross-reacting with the thymocytes was localized) for 5 days prior to and 3 days post immunization, hemagglutinin titres and the quantity of direct (IgM) and indirect (IgG) antibody-forming cells increased 2.5 times in comparison with the control. The preparations from the white matter of the brain and from the bone marrow failed to demonstrate such an effect.
D000373:Agglutinins / Q000096:biosynthesis*; D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects*; D001853:Bone Marrow / Q000032:analysis*; D001923:Brain Chemistry; D002417:Cattle; D002452:Cell Count; D002540:Cerebral Cortex / Q000032:analysis; D006388:Hemagglutinins / Q000096:biosynthesis*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA / Q000276:immunology; D009928:Organ Specificity; D010455:Peptides / Q000302:isolation & purification / Q000494:pharmacology*; D013154:Spleen / Q000276:immunology
D000373:Agglutinins; D006388:Hemagglutinins; D010455:Peptides
Vliianie veshchestv polipeptidnoĭ prirody, vydelennykh iz kory golovnogo mozga, na immunyĭ otvet u mysheĭ.