Caffeine potentiation of amphetamine: implications for hyperkinesis therapy.
Neither 0.05 mg/kg d-amphetamine nor 15 mg/kg caffeine alone produce amphetamine-like responding in rats trained in two-lever operant chambers to discriminate 0.8 mg/kg d-amphetamine from saline. The co-administration of the two drug doses produced responding similar to the 0.8 mg/kg d-amphetamine dose. A suggestion for the mechanism of action and a regimen of administration for caffeine in hyperkinetic children are discussed.
D000818:Animals; D002110:Caffeine / Q000494:pharmacology* / Q000627:therapeutic use; D003913:Dextroamphetamine / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D006801:Humans; D006948:Hyperkinesis / Q000188:drug therapy*; D051381:Rats
D002110:Caffeine; D003913:Dextroamphetamine