Bovine superoxide dismutase and copper ions potentiate the bactericidal effect of autoxidizing cysteine.
When cysteine is oxidized by oxygen, hydrogen peroxide is formed, and hydrogen peroxide is very toxic to Peptostreptococcus anaerobius VPI 4330-1. Native and inactivated superoxide dismutase increased the rate of oxidation of cysteine and thereby potentiated the toxic effect of cysteine. A similar increase in the rate of oxidation of cysteine and in the toxicity of cysteine was obtained with Cu2+.
D000332:Aerobiosis; D000818:Animals; D002417:Cattle; D003300:Copper / Q000494:pharmacology*; D003545:Cysteine / Q000378:metabolism*; D006861:Hydrogen Peroxide / Q000378:metabolism / Q000494:pharmacology*; D010084:Oxidation-Reduction; D010462:Peptostreptococcus / Q000187:drug effects*; D013482:Superoxide Dismutase / Q000494:pharmacology*
D003300:Copper; D006861:Hydrogen Peroxide; D013482:Superoxide Dismutase; D003545:Cysteine