Immunomodulating effects in vitro of a hydroxythiazolobenzimidazole in the absence of mitogenicity.
Wy-13, 876, a hydroxythiazolobenzimidazole, enhanced in vitro antibody formation by mouse spleen cells immunized with sheep red blood cells. The optimal dose was 25--50 microgram/culture. The compound did not have a mitogenic effect at any dose.
D000276:Adjuvants, Immunologic; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D000921:Antibody-Producing Cells / Q000187:drug effects; D001562:Benzimidazoles / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008938:Mitosis / Q000187:drug effects; D013844:Thiazoles / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D001562:Benzimidazoles; D013844:Thiazoles