title: Absorption studies with the anti-diarrhoeal agent ethacridine lactate in laboratory animals and man.
abstract: Tritiated 2-ethoxy-6,9-diaminoacridine (ethacridine lactate, Rivanol) has been orally administered to rat, dog, rabbit and man, and the distribution of radioactivity between urine and faeces determined. Complete recoveries of radioactivity were obtained from rat, rabbit and man. From direct measurement of levels of radioactivity, the maximum percentage of the dose excreted via the urine varied from 1.7% (man) to 6.1% (dog). Tritiated water accounted for nearly 50% of this amount. The low levels of radioactivity in plasma of dog and man and in the bile of rats following administration of 3H-ethacridine lactate suggested that there was only a low degree of oral absorption and substantiated previous reports that the drug is essentially unabsorbed in man. From fluorimetric measurements and the determination of levels of radioactivity in ether extracts of urine, it could be concluded that for all species less than 0.1% of the dose appeared in the urine as acridine-like material.
mesh_terms: D000166:Acridines / Q000378:metabolism*; D000284:Administration, Oral; D000328:Adult; D000818:Animals; D000930:Antidiarrheals / Q000008:administration & dosage / Q000378:metabolism*; D001646:Bile / Q000378:metabolism; D004285:Dogs; D004975:Ethacridine / Q000008:administration & dosage / Q000378:metabolism*; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D008875:Middle Aged; D011817:Rabbits; D051381:Rats; D014316:Tritium
chemical_list: D000166:Acridines; D000930:Antidiarrheals; D014316:Tritium; D004975:Ethacridine