Organic solvent soluble lipofuscin pigment in brain tissues of mice fed large amounts of polyunsaturated fats in presence and absence of various antioxidants.
The amount of lipid soluble fluorescent pigment is compared in brain tissues of mice fed a diet containing 10% safflower oil with and without a supplement of antioxidants as Vitamin E, Ascorbyl-Palmitate and Sodium-Selenite. Addition of 0.2 g/kg Vitamin E to the diet gives a high raise in the mortality. The addition of 0.2 g/kg Vitamin E and 0.5 g/kg Ascorbyl-Palmitate leads to higher values of extractable lipid soluble fluorescent pigment in mice brain tissues.
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D004041:Dietary Fats / Q000494:pharmacology*; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D005260:Female; D008062:Lipofuscin / Q000302:isolation & purification / Q000378:metabolism*; D051379:Mice; D010860:Pigments, Biological / Q000378:metabolism*; D012450:Safflower Oil; D012997:Solvents
D000975:Antioxidants; D004041:Dietary Fats; D005231:Fatty Acids, Unsaturated; D008062:Lipofuscin; D010860:Pigments, Biological; D012997:Solvents; D012450:Safflower Oil