Ca2+-transport inhibition by the antitumor agents adriamycin and daunomycin.
The antitumor agents adriamycin and daunomycin inhibit Ca2+-transport in mitochondria from Ehrlich ascites carcinoma cells as well as in a biphasic model system. The experimental results indicate that both antibiotics interact with phospholipids. The significance of these observations in the pharmacological behavior of these anticancer compounds is discussed.
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism; D003630:Daunorubicin / Q000494:pharmacology*; D004317:Doxorubicin / Q000494:pharmacology*; D051379:Mice; D008928:Mitochondria / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism
D010743:Phospholipids; D004317:Doxorubicin; D002118:Calcium; D003630:Daunorubicin