Response of anamnestic IgA-producing cells in the mouse gut after repeated intragastric immunization.
1) Repeated intragastric immunization after a 90-day interval results in a local immunologic memory. 2) Repeated intragastric immunization does not induce the same circulation of gut lymphocytes as does the initial oral immunization. 3) Measurement of circulating antibodies is a poor criterion for gauging the local immune status. 4) A gastric intubation dose of 4 X 10(9) SRBC given daily for 4 days appears to be suboptimal for the induction of a local immune response.
D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology*; D000941:Antigens / Q000008:administration & dosage; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D007070:Immunoglobulin A / Q000096:biosynthesis*; D007156:Immunologic Memory; D007413:Intestinal Mucosa / Q000276:immunology*; D007441:Intubation, Gastrointestinal; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C
D000941:Antigens; D007070:Immunoglobulin A