Influence of anthocyanoside treatment on the cholesterol-induced atherosclerosis in the rabbit.
We have studied the effect of treatment with anthocyanosides from Vaccinium myrtillis on cholesterol-induced atheroma of rabbits. We have found that the drug did not modify the serum cholesterol levels, but decreased the proliferation of the intima the extracellular matrix production the calcium and lipid deposition in the aorta, and the DNA and lipid contents. The alterations in the biochemical composition of the isolated brain microvessels were also diminished. The following mechanism may explain the protective action of the treatment: the collagen of the vessel walls participates in the control of vascular permeability. This permeability is increased by a cholesterol-rich diet. The protective drug interacts with collagen, increasing its cross-links, thus diminishing the permeability in small, as well as in large blood vessels.
D000818:Animals; D000872:Anthocyanins / Q000494:pharmacology*; D001013:Aorta, Thoracic; D001158:Arteries / Q000187:drug effects / Q000378:metabolism; D001161:Arteriosclerosis / Q000139:chemically induced / Q000517:prevention & control*; D001921:Brain / Q000098:blood supply / Q000187:drug effects; D002784:Cholesterol / Q000378:metabolism; D002791:Cholesterol, Dietary / Q000009:adverse effects*; D003094:Collagen / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D050356:Lipid Metabolism; D008297:Male; D011817:Rabbits
D000872:Anthocyanins; D002791:Cholesterol, Dietary; D003094:Collagen; D004247:DNA; D002784:Cholesterol