Pharmacological investigation of cardiovascular and haemodynamic effects of salts of ioxitalamic acid in anaesthetized dogs.
Aqueous solutions of salts of ioxitalamic acid were infected by intravenous, intracarotid, proximal intra-aortic, and intrafemoral route. We observed cardiovascular effects of small magnitude and short duration. They are composed of hypotension (intravenous and intracarotid route), hypotension followed by hypertension (intra-aortic route), changes of LVP, dLVP/dt and contractile strength parallel with those in blood pressure, bradycardia, increased femoral blood flow. Several factors seemed to be involved in the mechanism of these effects: vagal reflex, transient myocardial depression, peripheral vasodilating effect, increased volaemia. By all routes of administration used, the infection of non-iodinated solutions [NaCl, glucose, methylglucamine (MGL) and monoethanolamine (MEA) hydrochloride] of the same osmolarity as ioxitalamate solution, resulted in similar effects.
D000818:Animals; D001011:Aorta; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D002343:Carotid Artery, Internal; D002800:Cholinesterase Inhibitors; D002802:Cholinesterases / Q000097:blood; D004285:Dogs; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D005263:Femoral Artery; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006632:Histamine / Q000097:blood; D007269:Injections, Intra-Arterial; D007275:Injections, Intravenous; D007483:Iothalamic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D012039:Regional Blood Flow / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
D002800:Cholinesterase Inhibitors; D007483:Iothalamic Acid; D006632:Histamine; D002802:Cholinesterases