Effects of diazepam on succinylcholine-induced myalgia, potassium increase, creatine phosphokinase elevation, and relaxation.
Diazepam in a dose of 0.05 mg/kg was studied to determine its effect on a subsequently administered dose of 1 mg/kg of succinylcholine. This dose of diazepam prior to succinylcholine (1) significantly diminished the incidence of postoperative muscle pain; (2) decreased the usual increase in serum potassium; (3) did not prevent the rise in creatine phosphokinase; (4) reduced the incidence of muscle fasciculation; and (5) did not affect the magnitude or duration of the succinylcholine neuromuscular block. It was concluded that diazepam had several advantages over d-tubocurarine in the prevention of succinylcholine-induced muscle pain.
D003402:Creatine Kinase / Q000097:blood*; D003975:Diazepam / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009126:Muscle Relaxation / Q000187:drug effects*; D009132:Muscles / Q000187:drug effects; D009135:Muscular Diseases / Q000139:chemically induced*; D010149:Postoperative Pain / Q000139:chemically induced*; D011188:Potassium / Q000097:blood*; D013390:Succinylcholine / Q000009:adverse effects*; D014403:Tubocurarine / Q000494:pharmacology
D003402:Creatine Kinase; D013390:Succinylcholine; D003975:Diazepam; D011188:Potassium; D014403:Tubocurarine