Stress-induced modulation of the immune response.
After mice were exposed to a daily auditory stressor for varying lengths of time, the responses of their splenic lymphoid cells in vitro were assessed. Both the blastogenic activity of concanavalin A or lipopolysaccharide and the ability of immune lymphocytes to lyse P815 target cells showed the same patterns of immunosuppression and enhancement.
D000818:Animals; D003601:Cytotoxicity Tests, Immunologic; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007111:Immunity, Cellular; D007165:Immunosuppression Therapy; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009622:Noise; D013154:Spleen / Q000276:immunology; D013312:Stress, Physiological / Q000097:blood; D013315:Stress, Psychological / Q000502:physiology*; D013997:Time Factors
D006854:Hydrocortisone