Activation of the alternative complement pathway by Torulopsis glabrata.
Torulopsis glabrata is a yeast-like fungus with increasing importance as an opportunistic human pathogen. The role of serum complement in resistance to this infection was studied by chemotactic and opsonic assays. The results indicate that T. glabrata activates complement via the alternative pathway. This may be an important mechanism in host immunity to this fungus.
D002175:Candida / Q000276:immunology*; D002634:Chemotaxis, Leukocyte; D003167:Complement Activation; D003175:Complement C2 / Q000172:deficiency; D003179:Complement C3b; D003170:Complement Pathway, Alternative; D006801:Humans; D009504:Neutrophils; D010587:Phagocytosis
D003175:Complement C2; D003179:Complement C3b