Ophiocordin, an antifungal antibiotic of Cordyceps ophioglossoides.
An unknown antibiotic, ophiocordin, C21H22N2O8, MW: 430, was isolated from submerged cultures of Cordyceps ophioglossoides, strain TU 276, grown in a glycerol soybean meal medium at 27 degrees C. The antibiotic was extracted from acidified culture fluids with n-butanol and purified by subsequent column chromatography on DEAE-Sephadex and cellulose. Studies including nuclear magnetic resonance and mass spectrometry resulted in proposals of partial structures of the molecule. Inhibition by ophiocordin could be demonstrated for a small number of fungi belonging to different taxonomic groups. Bacteria were not inhibited. The antifungal effect was antagonized by ammonia and nitrate ions and by certain amino acids.
D000935:Antifungal Agents / Q000032:analysis / Q000096:biosynthesis / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D003470:Culture Media; D004355:Drug Stability; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D062385:Hydroxybenzoates / Q000032:analysis; D006999:Hypocreales / Q000378:metabolism*; D003904:Mitosporic Fungi / Q000187:drug effects; D012995:Solubility; D013045:Species Specificity
D000935:Antifungal Agents; D003470:Culture Media; D062385:Hydroxybenzoates