[Further observations by electron microscope of striated muscle in progressive Duchenne muscular dystrophy].
Gastrocnemius muscle fragments of children affected by clinically diagnosed progressive muscular dystrophy of Duchenne have been studied. At the light microscope, in the semi-thin sections, the more evident changes are represented by a wide diameter range of the fibers and fatty infiltration. Some fibers show numerous nuclei in their central part, a sarcoplasmic degeneration of vacuolar type and an irregular and tortuous course of the myofibrils. Moreover, the ultrastructural findings have shown characteristic changes in myofilaments and Z bands represented by: streaming of the Z bands, collection of the triads and concentric laminated bodies. These observations have pointed out a certain gradualness of the alterations, starting from focal changes of Z band to the complete disarrangement of myofilaments.
D002648:Child; D003599:Cytoskeleton / Q000648:ultrastructure; D006801:Humans; D008854:Microscopy, Electron; D009132:Muscles / Q000473:pathology*; D009136:Muscular Dystrophies / Q000473:pathology*
Ulteriori osservazioni al microscopio elettronico del muscolo striato nella distrofia muscolare progressiva di Duchenne.