[Synthesis and biological activity of 7-(2-nitroimidazoles and 7-(2-aminoimidazole) methyleneamino cephalosporin and their derivatives].
The synthesis of 7-[[(1-methyl-2-nitro-1H-imidazol-5-yl)methylene]amino] and 7-[[(2-amino-1-methyl-1H-imidazol-5-yl)methyle-ne]amino]cephalosporanic acids and of some derivatives is described. Their physico-chemical characteristics are reported. The compounds show no appreciable antibacterial activity in vitro. They show no synergy with cephaloridine against Enterobacter cloacae 214 (producer of class I beta-lactamase) and therefore have no anti-beta-lactamase activity.
D002511:Cephalosporins / Q000138:chemical synthesis* / Q000494:pharmacology; D004754:Enterobacter / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D009593:Nitroimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared
D002511:Cephalosporins; D009593:Nitroimidazoles
Sintesi e attività biologica di alcune 7-(2-nitroimidazolil) e 7-(2-amminoimidazolil)metilenammino cefalosporine e loro derivati.