title: Carbamazepine: prevention of alcohol withdrawal seizures.
abstract: Effects of carbamazepine on alcohol withdrawal seizures and symptoms were studied in rats. Carbamazepine was administered during alcohol feeding and continued during alcohol withdrawal. When carbamazepine serum levels were above 3 micrograms per milliliter, alcohol withdrawal seizures were not observed. Carbamazepine also alleviated alcohol withdrawal symptoms, especially heightened spontaneous activity, startle to noise, stereotyped chewing movements, and intermittent body stiffening.
mesh_terms: D000437:Alcoholism / Q000097:blood / Q000150:complications*; D000818:Animals; D002220:Carbamazepine / Q000097:blood / Q000627:therapeutic use*; D006801:Humans; D051381:Rats; D012640:Seizures / Q000097:blood / Q000209:etiology / Q000517:prevention & control*; D013375:Substance Withdrawal Syndrome / Q000097:blood / Q000150:complications / Q000188:drug therapy*
chemical_list: D002220:Carbamazepine