Effect of malonate and maleate on growth and brefeldin A formation in Curvularia lunata.
Malonate exerted a stronger inhibitory effect on brefeldin A production than on mycelia growth in cultures of Curvularia lunata especially at inhibitory levels of 100 to 200 mM. The extent of 200 mM malonate inhibition of growth and brefeldin A production was greater in cultures treated with malonate prior to inoculation than those treated following 5 days after inoculation. Maleate at levels of 40 to 220 mM activated brefeldin A formation in cultures though exerting variable effects on mycelia growth.
D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D003517:Cyclopentanes / Q000378:metabolism; D008298:Maleates / Q000378:metabolism*; D008314:Malonates / Q000378:metabolism*; D003904:Mitosporic Fungi / Q000254:growth & development / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D003517:Cyclopentanes; D008298:Maleates; D008314:Malonates