Cell survival and cytogenetic responses to 125I-UdR in cultured mammalian cells.
The relative toxicity of DNA precursors labeled with iodine-125, iodine-131, or hydrogen-3 was studied in exponentially growing Chinese hamster cells. Per decay, iodine-125 was found to be approximately 12 times as lethal as iodine-131 and 16 times as lethal as hydrogen-3. Chromosomal aberrations induced in these cells by the three radionuclides occurred with the same relative efficacy as their lethal effects.
D000818:Animals; D002470:Cell Survival / Q000528:radiation effects*; D002478:Cells, Cultured; D002842:Chromatids / Q000528:radiation effects; D002869:Chromosome Aberrations; D006224:Cricetinae; D004583:Electrons; D007065:Idoxuridine; D007457:Iodine Radioisotopes / Q000009:adverse effects*; D011831:Radiation Genetics; D014316:Tritium / Q000009:adverse effects
D007457:Iodine Radioisotopes; D014316:Tritium; D007065:Idoxuridine