An electrophysiological correlate of amphetamine revealed motor imbalance in albino rats.
Ten out of eleven Wistar rats displayed a reliable interhemispheric asymmetry of the secondary slow negative wave (SNW) of the visual evoked potential. A more synchronized EEG was observed on the side of facilitated SNW. The analysis of rotation directionality in the rotometer of these rats after IP (+)-amphetamine administration (1.25 mg/kg) showed that rats reliably rotated towards the side with a more facilitated SNW. It is believed that an imbalance of nigrostriatal DA content underlies the interhemispheric asymmetry of EEG and evoked potentials.
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D001519:Behavior / Q000187:drug effects*; D001921:Brain / Q000187:drug effects*; D004569:Electroencephalography; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D006801:Humans; D009043:Motor Activity / Q000187:drug effects; D010775:Photic Stimulation; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects*
D000661:Amphetamine