[Investigations on the antimicrobial activity of amin-aldehyde-condensates. 3. Communication: n,o-acetals (author's transl)].
In the scope of our research about the antimicrobial activity of amin-aldehyde-condensates a number of partly new N,O-acetals was synthesized by reaction of formaldehyde with several alcohols and secondary amines. Structures and physically constants are shown in the tables 1 and 2. The antimicrobial activity is demonstrated by the results of the disk-test (table 3), of the minimal inhibition concentration (MIC, table 4) and the suspension and area disinfecting test following the methods of the DGHM (tables 5 and 6). It may be shown, that the N,O-acetals have both germistatic activity mainly versus Staphylococcus aureus, Bacillus subtilis, Aspergillus niger and Penicillium glaucum and germicidal activity versus the gram-negative testgerms especially Pseudomonas aeruginosa.
D000080:Acetals / Q000138:chemical synthesis / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D005557:Formaldehyde / Q000378:metabolism; D005658:Fungi / Q000187:drug effects
D000080:Acetals; D005557:Formaldehyde
Untersuchungen zur antimikrobiellen Wirksamkeit von Amin-Aldehyd-Kondensaten 3. Mitteilung: N,O-Acetale.