Magnetic microspheres: synthesis of a novel parenteral drug carrier.
The synthesis and characterization of a novel parenteral drug carrier capable of area specific localization by magnetic means are described. The carrier consists of human serum albumin microspheres, average of 1 micrometer in diameter, in which a magnetizable material (magnetite) and a prototype drug (doxorubicin) are entrapped. Stabilization of the microsphere matrix by formaldehyde, 2,3-butanedione, and heat conferred equal stability to the matrix but differentially affected the in vitro drug release rate. Release doxorubicin was chemically identical to the starting material.
D002254:Carbonates; D003931:Diacetyl; D004317:Doxorubicin / Q000008:administration & dosage; D004355:Drug Stability; D005557:Formaldehyde; D006358:Hot Temperature; D008863:Microspheres; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D012709:Serum Albumin
D002254:Carbonates; D004364:Pharmaceutical Preparations; D012709:Serum Albumin; D005557:Formaldehyde; D004317:Doxorubicin; D003931:Diacetyl