Microheterogeneity in thrombin standards.
Potency estimations of thrombin have been performed using clotting and synthetic substrates in parallel assays. The International Standard and the Nordic Standard of thrombin have both been used as references. Divergencies in estimated unitage necessitated a study on possible heterogeneities in the standard preparations presented in this paper.
D000818:Animals; D001777:Blood Coagulation; D002417:Cattle; D002850:Chromatography, Gel; D006629:Hirudins / Q000494:pharmacology; D006801:Humans; D010974:Platelet Aggregation; D013917:Thrombin / Q000592:standards*
D006629:Hirudins; D013917:Thrombin