Sodium retention in chronic liver disease: lack of a natriuretic factor?
An acute volume expansion in water diuresis has been induced in 8 patients with liver cirrhosis and in 8 normal subjects, taken as controls. A two hour postinfusion urine sample has been utilized to obtain the urine fraction with natriuretic activity. This activity was assayed in 16 rats. Our results confirm a significantly lower natriuretic activity of cirrhotic urine fractions than those of controls.
D000818:Animals; D004231:Diuresis; D006801:Humans; D008099:Liver / Q000378:metabolism; D008103:Liver Cirrhosis / Q000378:metabolism*; D009318:Natriuresis; D051381:Rats; D012964:Sodium / Q000378:metabolism*
D012964:Sodium