[Studies on the fibrinolytic system in ruptured intracranial aneurysm. Part 1. Monitoring of the antifibrinolytic therapy through repeated measurement of SK-euglobulin lysis time and FDP (author's transl)].
Streptokinase euglobulin lysis time (SK-ELK), fibrin and fibrinogen degradation products (FDP) and fibrinogen in the blood were determined to know the proper dosage of t-AMCHA which would not cause the ischemic complications yet suffice to prevent the rebleeding of ruptured intracranial aneurysm. SK-ELT was almost doubled(130 sec) by the administration of 6-8g/day of t-AMCHA within 24-48h in normal control. On the other hand, SK-ELT in SAH patients fluctuated tremendously during ten days after the first bleeding. FDP took a high value soon after the first bleeding in grade IV and V patients. Increase in FDP was also observed following rebleeding in one case, following severe vasospasm, and following progressive neurological deterioration, and the increase in FDP was concentrated 4-10 days after SAH. Fibrinogen showed a tendency to increase gradually after the administration of t-AMCHA, and this increase of fibrinogen would be one of the alarming signs of the development of ischemic complications. From these results, it was suggested that the dosis of t-AMCHA should be determined precisely according to the result of repeated monitoring, and the dosis should be as such that it could constantly keep SK-ELT at 130-150 sec.
D000284:Administration, Oral; D003509:Cyclohexanecarboxylic Acids / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism*; D005340:Fibrinogen / Q000378:metabolism; D005342:Fibrinolysis / Q000187:drug effects; D006801:Humans; D007275:Injections, Intravenous; D002532:Intracranial Aneurysm / Q000097:blood* / Q000188:drug therapy; D008875:Middle Aged; D012422:Rupture, Spontaneous; D012712:Serum Globulins / Q000378:metabolism*; D013300:Streptokinase / Q000378:metabolism*
D003509:Cyclohexanecarboxylic Acids; D005338:Fibrin Fibrinogen Degradation Products; D012712:Serum Globulins; D005340:Fibrinogen; D013300:Streptokinase