Synthesis and anti-inflammatory properties of some pyrrolo(1H,3H)[3,4-d]pyrimidin-2-ones and pyrrolo(1H,6H)[3,4-d]pyrimidin-2-ones.
The unequivocal synthesis of some terms belonging to the two isomeric classes of the pyrrolo(1H,3H)[3,4-d]pyrimidin-2-ones and of the pyrrolo(1H,6H)[3,4-d]pyrimidin-2-ones is reported. Some of these compounds are active in inhibiting the development of the carrageenin edema, of the granuloma cotton pellet and of the adjuvant arthritis in the rat when administered orally.
D000818:Animals; D000893:Anti-Inflammatory Agents; D001169:Arthritis, Experimental / Q000188:drug therapy; D001241:Aspirin / Q000627:therapeutic use; D004487:Edema / Q000188:drug therapy; D005260:Female; D007213:Indomethacin / Q000627:therapeutic use; D008297:Male; D051379:Mice; D011744:Pyrimidinones / Q000138:chemical synthesis / Q000627:therapeutic use; D011758:Pyrroles / Q000138:chemical synthesis / Q000627:therapeutic use; D051381:Rats
D000893:Anti-Inflammatory Agents; D011744:Pyrimidinones; D011758:Pyrroles; D001241:Aspirin; D007213:Indomethacin