title: [Polymorphisms and deficient drug metabolism as triggers of toxic reactions (author's transl)].
abstract: The influences of polymorphisms and pharmacokinetic defects of drug metabolism as causes of toxic drug reactions are presented. The different mechanisms of toxic side effects mediated by alterations of the metabolism and excretion of drugs are discussed.
mesh_terms: D000818:Animals; D000983:Antipyrine / Q000009:adverse effects; D003493:Cyclacillin / Q000009:adverse effects; D003975:Diazepam / Q000009:adverse effects; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced; D010597:Pharmacogenetics; D010653:Phenylbutazone / Q000009:adverse effects; D011110:Polymorphism, Genetic; D011324:Primidone / Q000009:adverse effects; D051381:Rats
chemical_list: D011324:Primidone; D003493:Cyclacillin; D010653:Phenylbutazone; D003975:Diazepam; D000983:Antipyrine
vernacular_title: Polymorphismen und Defekte des Arzneimittelstoffwechesels als Ursache toxischer Reaktionen.