[On the effect of iodine containing opaque media on erythrocyte acetylcholinesterase (author's transl)].
Clinical symptoms of side effects by iodinated opaque media are approximately similar to those caused by inhibition of acetylcholinesterase. The inhibition of acetylcholinesterase of human erythrocytes was tested with the following opaque media in vivo and in vitro: adipiodonmeglumine, meglumine-iothalamate and sodium-iothalamate. Apparently there is no connection between opaque media induced incompatibility and the inhibition of acetylcholinesterase because 1. by the time maximal inhibition is reached most of the renally excreted opaque media has been eliminated, and because 2. a fairly rapid reversibility of the inhibition follows. For patients with congenital variants of acetylcholinesterase it could be of clinical consequence under succinyldicholinanaesthesia.
D000110:Acetylcholinesterase / Q000097:blood*; D002800:Cholinesterase Inhibitors; D003287:Contrast Media / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology*; D006801:Humans; D066298:In Vitro Techniques; D007482:Iothalamate Meglumine / Q000494:pharmacology; D007483:Iothalamic Acid / Q000494:pharmacology; D008536:Meglumine / Q000031:analogs & derivatives / Q000494:pharmacology; D013997:Time Factors
D002800:Cholinesterase Inhibitors; D003287:Contrast Media; D007483:Iothalamic Acid; D008536:Meglumine; D000110:Acetylcholinesterase; D007482:Iothalamate Meglumine
Zur Wirkung von jodhaltigen Kontrastmitteln auf die Erythrozyten-Acetylcholinesterase.