A new selective antagonist of prostaglandins: 20-methyl-13,14-didehydro-PGF2 alpha.
20-methyl-13,14-didehydro-PGF2 alpha has been assayed for antagonistic activity against PGF2 alpha and PGE2 on different smooth msucle preparations in vitro. This compound may be considered a selective and probably a competitive antagonist of PGF2 alpha on rat uterus in vitro.
D000818:Animals; D015237:Dinoprost / Q000031:analogs & derivatives*; D005260:Female; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects; D011448:Prostaglandin Antagonists; D011460:Prostaglandins F / Q000037:antagonists & inhibitors; D011461:Prostaglandins F, Synthetic / Q000494:pharmacology*; D051381:Rats; D014599:Uterus / Q000187:drug effects
D011448:Prostaglandin Antagonists; D011460:Prostaglandins F; D011461:Prostaglandins F, Synthetic; C027038:20-methyl-13,14-(didehydroprostaglandin) F2alpha; D015237:Dinoprost