Sensory irritation to formaldehyde and acrolein during single and repeated exposures in mice.
Mice were exposed to various concentrations of formaldehyde or acrolein. Concentration-response relationships were developed by measuring per cent decrease in respiratory rate, indicating upper respiratory tract sensory irritation. Relationships are presented between the concentration associated with a 50% respiratory decrease and TLVs. A summary of other animal inhalation studies is presented. The basis for the acrolein and formaldehyde TLVs are reviewed. Mice exposed for 4 days showed increasing sensitivity daily for both compounds. A re-evaluation of the TLVs is suggested.
D000171:Acrolein / Q000633:toxicity*; D000447:Aldehydes / Q000633:toxicity*; D000818:Animals; D003315:Cornea / Q000294:innervation; D005557:Formaldehyde / Q000633:toxicity*; D008297:Male; D008452:Maximum Allowable Concentration; D051379:Mice; D012120:Respiration Disorders / Q000139:chemically induced*; D012143:Respiratory Physiological Phenomena; D012137:Respiratory System / Q000294:innervation; D013045:Species Specificity
D000447:Aldehydes; D005557:Formaldehyde; D000171:Acrolein