title: Schedule shifts, life quality and quantity--modeled by murine blood pressure elevation and arthropod life span.
abstract: During the span from 50 to 100 days and beyond, the male stroke-prone Okamoto rat develops systolic blood pressure measures in excess of 200 mm Hg. In the course of developing such a marked elevation in systolic blood pressure mean, this intermittently handled male Okamoto rat exhibits a statistically significant circadian rhythm with large amplitude. This amplitude may represent, at least in part, a response to intermittent handling; it is several times larger than the amplitude for spontaneously mesor-hypertensive (but not stroke-prone) female animals of the same age.
mesh_terms: D000375:Aging; D000818:Animals; D001794:Blood Pressure; D002561:Cerebrovascular Disorders / Q000235:genetics; D002940:Circadian Rhythm; D006339:Heart Rate; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008017:Life Expectancy; D008297:Male; D008954:Models, Biological; D011788:Quality of Life; D051381:Rats; D011919:Rats, Inbred Strains