title: Mammalian hexokinases: a system for the study of co-operativity in monomeric enzymes.
abstract: Kinetic and structural studies have been carried out of two isoenzymes of hexokinase from the rat, hexokinase II and glucokinase. Although both enzymes are monomeric, hexokinase II has a molecular weight double that of glucokinase and resembles a dimer of glucokinase. The co-operativity of glucokinase, which is not observed for hexokinase II, appears to be kinetic in origin rather than the consequence of ineractions between distinct glucose-binding sites.
mesh_terms: D000818:Animals; D002846:Chromatography, Affinity; D005941:Glucokinase / Q000378:metabolism*; D006593:Hexokinase / Q000302:isolation & purification / Q000378:metabolism*; D007700:Kinetics; D008956:Models, Chemical; D008970:Molecular Weight; D051381:Rats
chemical_list: D006593:Hexokinase; D005941:Glucokinase