title: [Studies on toxicity and fertility of escin in the rat (author's transl)].
abstract: The DL50 of escin was determined after i.p. application. Juvenile male rats were treated with 2X5 mg/kg escin at age 32 days. After they had reached fertility, kidneys, testes and sperm were examined. The high dose of escin used did not affect fertility and a nephrotoxic activity could not be detected either.
mesh_terms: D000367:Age Factors; D000818:Animals; D004928:Escin / Q000494:pharmacology* / Q000633:toxicity; D005298:Fertility / Q000187:drug effects*; D007668:Kidney / Q000187:drug effects; D007928:Lethal Dose 50; D008297:Male; D051381:Rats; D012503:Saponins / Q000494:pharmacology*; D013094:Spermatozoa / Q000187:drug effects; D013737:Testis / Q000187:drug effects
chemical_list: D012503:Saponins; D004928:Escin
vernacular_title: Toxizitäts- und Fertilitätsstudien mit Aescin bei der Ratte.