Toxic effects of subconjunctival dicloxacillin.
Rabbits were given dicloxacillin subconjunctively. Very high levels of the drug were recovered from the aqueous humor. Soon after injection, corneal opacification, epithelial sloughing and conjunctival necrosis were noted clinically. The globes were studied histopathologically.
D000818:Animals; D003228:Conjunctiva / Q000473:pathology; D003315:Cornea / Q000473:pathology; D003318:Corneal Opacity / Q000139:chemically induced* / Q000473:pathology; D004009:Dicloxacillin / Q000008:administration & dosage / Q000633:toxicity*; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D007267:Injections; D008297:Male; D009336:Necrosis; D011817:Rabbits
D004009:Dicloxacillin