Some effects of prostaglandin on corpora lutea and on the uterus in the cycling dog.
The effect of prostaglandin PGF2alpha was investigated on the progesterone production in the corpora lutea and on the occurrence of amino acids and carbohydrates in the uteri of seven beagles in metoestrus (D-36 to D-42). The dose, 15 mg in all (3 X 5 mg with intervals of 1 and 24 hours), was injected i.m. After ovariectomy and hysterectomy it appeared that 5 hours after the last injection in conversion of pregenolone into progesterone in the corpora lutea was greatly reduced that in the uterus much more fructose, glucose, and glucuronic acid was present than could by expected at the time of the cycle. After 24 hours the progesterone production was still low and in the uterus the fructose production had increased and lactic acid was formed. Four days after the last injection, the progesterone production in the corpora lutea was normal again and the amounts of fructose and of glucose in the uterus showed the normal values; the concentrations of glucuronic acid and of lactic acid were still elevated, but they were reducing. Seemigly 15 mg of PGF2alpha injected i.m. in dogs caused a temporary blocking of progesterone production in the corpora lutea, accompanied by the formation of glucuronic acid in the uteri van zeven beagles in metoestrus (D-36 - D142). De dosis bedroeg in total 15 mg (3 X 5 small amounts of fructose and of lactic acid in the uterus.
D000818:Animals; D003338:Corpus Luteum / Q000187:drug effects*; D004285:Dogs / Q000502:physiology*; D004971:Estrus; D005260:Female; D005632:Fructose / Q000096:biosynthesis; D005965:Glucuronates / Q000096:biosynthesis; D007773:Lactates / Q000096:biosynthesis; D011247:Pregnancy; D011284:Pregnenolone / Q000378:metabolism; D011374:Progesterone / Q000096:biosynthesis / Q000378:metabolism; D011460:Prostaglandins F / Q000494:pharmacology*; D014599:Uterus / Q000187:drug effects*
D005965:Glucuronates; D007773:Lactates; D011460:Prostaglandins F; D005632:Fructose; D011374:Progesterone; D011284:Pregnenolone