Investigation of the role of prolonged emotional stress in the genesis of hypercholesteremia and hypertension.
In experiments on freely moving rabbits, exposed to prolonged (for 2 h) interrupted stimulation of negative emotiogenic zones of the hypothalamus through implanted electrodes daily for 4 months, the development of a lasting endogenous hypercholesteremia and of a mild but lasting hypertension was observed. Changes in the cholesterol concentration were greater if stimulation continued in conjunction with daily feeding of the rabbits with small doses of methylthiouracil.
D000818:Animals; D001931:Brain Mapping; D004558:Electric Stimulation; D006801:Humans; D006937:Hypercholesterolemia / Q000209:etiology*; D006973:Hypertension / Q000209:etiology*; D007031:Hypothalamus / Q000503:physiopathology*; D008297:Male; D011817:Rabbits; D013315:Stress, Psychological / Q000150:complications*; D013997:Time Factors