[Effects of graded doses of copper complexes with L-aminoacids on gastric acid secretion in the rat].
Gastric acid responses to intragastric administration of graded doses (14-30-45 mg/Kg) of copper (II) complexes with aminoacids (two simple complexes, Cu-Trp2 and Cu-Phe2, and on mixed complex, Cu-Trp-Phe) were investigated in Shay rats. The results (% inhibition of H+ mEq/4h) shown that graded doses of copper complexes caused a progressive inhibition on gastric acid secretion, and that percentage inhibition values were, for all complexes, in linear correlation with employed doses. A possible mechanism by which copper complexes affect gastric acid secretion is discussed.
D000818:Animals; D003300:Copper / Q000494:pharmacology*; D004151:Dipeptides / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D010649:Phenylalanine / Q000494:pharmacology; D051381:Rats; D014364:Tryptophan / Q000494:pharmacology
D004151:Dipeptides; C028281:phenylalanyltryptophan; D010649:Phenylalanine; D003300:Copper; D014364:Tryptophan
Effetti di dosi scalari di complessi rameici con L-aminoacidi sulla secrezione acida gastrica nel ratto.