Milk precipitins in selective IgA deficiency.
Precipitating antibody to cow milk's antigens (commonly bovine IgM) is found in 40-50% of selective IgA deficient patients. These precipitins may obscure the diagnosis of selective IgA deficiency by formation of anti-antiserum precipitin rings in radial immunodiffusion. Abnormal immunoregulatory function along with excess absorption of milk antigens in the absence of secretory IgA may be predisposing factors. Elimination of dietary cow's milk results in disappearance of these antibodies.
D000818:Animals; D002417:Cattle; D004406:Dysgammaglobulinemia / Q000276:immunology*; D005500:Follow-Up Studies; D006801:Humans; D007070:Immunoglobulin A; D007075:Immunoglobulin M; D008892:Milk / Q000276:immunology*; D011234:Precipitins
D007070:Immunoglobulin A; D007075:Immunoglobulin M; D011234:Precipitins