Quadruple vaccines containing pertussis and poliomyelitis vaccines.
Quadruple vaccines (DTP-P), prepared by mixing crude adsorbed Salk poliomyelitis vaccines, heat-killed pertussis vaccines and adsorbed purified diphtheria and tetanus toxoids were found to be toxic for mice. However, by using purified poliomyelitis and heat-killed formalinized pertussis components, vaccines were prepared that were non-toxic. The pertussis component of these vaccines retained potency over extended periods of storage. Stable, potent DTP-P vaccines offer an excellent alternative to DTP and live poliomyelitis vaccine in the basic immunization of infants and children.
D000818:Animals; D004168:Diphtheria Toxoid / Q000592:standards / Q000633:toxicity; D005557:Formaldehyde; D006358:Hot Temperature; D051379:Mice; D010567:Pertussis Vaccine / Q000592:standards / Q000633:toxicity*; D011054:Poliovirus Vaccine, Inactivated / Q000592:standards / Q000633:toxicity*; D013745:Tetanus Toxoid / Q000592:standards / Q000633:toxicity
D004168:Diphtheria Toxoid; D010567:Pertussis Vaccine; D011054:Poliovirus Vaccine, Inactivated; D013745:Tetanus Toxoid; D005557:Formaldehyde