[Teratologic-neurotoxicologic studies on biglumide (K-2004) and thalidomide].
Comparison of the teratogenic and neurotoxic influence of thalidomide with the new hypnosedative preparation Biglumide (K-2004) revealed significant differences. Malformations could be seen only after treatment with thalidomide. Some results concerning the thalidomide-treated group of animals could be interpreted as a retardation of development in the posterior root ganglia.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000196:embryology; D001643:Bridged Bicyclo Compounds / Q000009:adverse effects*; D001952:Bridged-Ring Compounds / Q000009:adverse effects*; D002490:Central Nervous System / Q000002:abnormalities*; D003508:Cycloheptanes / Q000009:adverse effects; D005260:Female; D005727:Ganglia, Spinal / Q000187:drug effects / Q000196:embryology; D006993:Hypnotics and Sedatives / Q000009:adverse effects*; D008431:Maternal-Fetal Exchange; D010525:Peripheral Nerves / Q000187:drug effects / Q000196:embryology; D011247:Pregnancy; D011817:Rabbits; D013127:Spinal Nerves / Q000187:drug effects / Q000196:embryology; D013723:Teratogens; D013792:Thalidomide / Q000009:adverse effects* / Q000031:analogs & derivatives*
D001643:Bridged Bicyclo Compounds; D001952:Bridged-Ring Compounds; D003508:Cycloheptanes; D006993:Hypnotics and Sedatives; D013723:Teratogens; D013792:Thalidomide; C006161:taglutimide
Teratologisch-neurotoxische Prüfung von Biglumid (K-2004) und Thalidomid.