[Membrane stabilizing effect of medicinal substances used for the treatment of chronic venous insufficiency].
Experiments "in vitro" have brought evidence that butadion, escinol, esculetin, glyvenol, rutin, escin and the summary flavor noid preparation are capable of stabilizing erythrocytes membranes with the cells subjected to hypotonic hemolysis. Depending upon optimal concentrations the activity of the substances was within the range of 10(-3) to 10(-8). As concerns the intensity of the effect in the optimal concentration (10(-5) M), that corresponds to the one built up in the blood of patients given the therapeutic dose of the drug, the action of glyvenol was 1.6-3.5 times superior to that of the other compounds.
D004910:Erythrocyte Membrane / Q000187:drug effects*; D004912:Erythrocytes / Q000187:drug effects*; D005419:Flavonoids / Q000494:pharmacology*; D006027:Glycosides / Q000494:pharmacology*; D009996:Osmotic Fragility / Q000187:drug effects; D012431:Rutin / Q000494:pharmacology
D005419:Flavonoids; D006027:Glycosides; D012431:Rutin
Membranostabiliziruiushchiĭ éffekt lekarstvennykh sredstv, primeniaemykh dlia lecheniia khronicheskoĭ venoznoĭ nedostatochnosti.