The effect of Schistosoma mansoni infection, and of oxamniquine, a new antischistosomal drug on some vitamins in the livers of hamsters.
The hepatic levels of thiamine, pantothenic acid and niacin in hamsters infected with S. mansoni were depressed, while the levels of riboflavin and pyridoxine remained unchanged. A single dose of oxamniquine, 10-50 mg/kg, brought the levels of thiamine, pantothenic acid and niacin to values not significantly different from those in non-infected controls, but lowered the concentrations of riboflavin and pyridoxine in infected hamsters.
D000818:Animals; D050260:Carbohydrate Metabolism; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D008099:Liver / Q000032:analysis* / Q000378:metabolism; D009600:Nitroquinolines / Q000494:pharmacology*; D010073:Oxamniquine / Q000494:pharmacology* / Q000627:therapeutic use; D012550:Schistosoma mansoni; D012552:Schistosomiasis / Q000188:drug therapy / Q000378:metabolism*; D013997:Time Factors; D014803:Vitamin B Complex / Q000032:analysis*
D009600:Nitroquinolines; D010073:Oxamniquine; D014803:Vitamin B Complex