Neonatal experimental autoimmune myasthenia gravis.
Neonatal rats born of and nursed by mothers immunized with Torpedo acetylcholine receptor protein developed a defect of neuromuscular transmission as indicated by reduced miniature endplate potential amplitudes. It is likely that antibodies to the Torpedo receptor protein were passively transferred to the neonates in the milk. With the exception of the route of transfer, this neonatal form of experimental autoimmune myasthenia gravis appears to be similar to its human counterpart, and thus can serve as an experimental model.
D000818:Animals; D000831:Animals, Newborn; D000906:Antibodies / Q000032:analysis; D001327:Autoimmune Diseases; D005260:Female; D005399:Fishes; D008431:Maternal-Fetal Exchange; D008564:Membrane Potentials; D009157:Myasthenia Gravis; D009469:Neuromuscular Junction / Q000503:physiopathology; D011247:Pregnancy; D011248:Pregnancy Complications; D051381:Rats; D011950:Receptors, Cholinergic / Q000276:immunology*
D000906:Antibodies; D011950:Receptors, Cholinergic