Intravesical instillation of dilute formalin for treatment of cyclophosphamide-induced hemorrhagic cystitis in two dogs.
Sterile hemorrhagic cystitis induced by cyclophosphamide therapy was diagnosed in 2 dogs. Clinical signs included pollakiuria, hematuria, and stranguria. The signs were progressive and referable to long-term oral cyclophosphamide administration. Dilute (1%) formalin was used to treat the hemorrhagic cystitis. Clinical control of hemorrhage was achieved in both cases, and hemorrhage did not recur.
D000818:Animals; D003520:Cyclophosphamide / Q000009:adverse effects*; D003556:Cystitis / Q000139:chemically induced / Q000188:drug therapy / Q000662:veterinary*; D004283:Dog Diseases / Q000139:chemically induced / Q000188:drug therapy*; D004285:Dogs; D005260:Female; D005557:Formaldehyde / Q000008:administration & dosage* / Q000627:therapeutic use; D006417:Hematuria / Q000662:veterinary; D006470:Hemorrhage / Q000139:chemically induced / Q000188:drug therapy / Q000662:veterinary*; D014546:Urinary Catheterization
D005557:Formaldehyde; D003520:Cyclophosphamide