Effect of creatinine on various experimentally induced inflammatory models.
Creatinine, an aminoacid, has been studied for its anti-inflammatory activity. It is orally effective in suppressing the inflammatory responses produced by carrageenan, 5-hydroxytryptamine, nystatin and formaldehyde. It is observed that the antiinflammatory effect of creatinine is not owing to counter irritant action. It is suggested that it may partially be mediating its anti-inflammatory activity by interfering with the action or/and synthesis of prostaglandins. Like phenylbutazone it also possesses an analgesic action.
D000208:Acute Disease; D000284:Administration, Oral; D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents; D002351:Carrageenan / Q000494:pharmacology; D002908:Chronic Disease; D003401:Creatine / Q000494:pharmacology; D003404:Creatinine / Q000008:administration & dosage / Q000627:therapeutic use*; D004341:Drug Evaluation; D004487:Edema / Q000188:drug therapy; D005260:Female; D005557:Formaldehyde / Q000494:pharmacology; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D009761:Nystatin / Q000494:pharmacology; D010653:Phenylbutazone / Q000627:therapeutic use; D011448:Prostaglandin Antagonists; D051381:Rats; D012701:Serotonin / Q000494:pharmacology
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D011448:Prostaglandin Antagonists; D009761:Nystatin; D005557:Formaldehyde; D012701:Serotonin; D002351:Carrageenan; D003404:Creatinine; D010653:Phenylbutazone; D003401:Creatine