The anticonvulsant and CNS activity of N-butyryl-N-butylurea in mice.
As a further extension of our studies related to CNS activity of substituted butylureas, a number of derivatives of butylurea were synthesized. Among these a derivative of n-butylurea, N-butyryl-N-butylurea (NBNB) was prepared by acylation of n-butylurea with butyryl chloride in pyridine. The compound was found to possess considerable sedative-hypnotic action. Sleeping time of pentobarbital and barbital was significantly potentiated by NBNB. The compound also exhibited moderate anti-tremorine action and produced significant reduction in the activity ratio for Treadmill experiments. Significant anticonvulsive activity of NBNB was observed against strychnine, pentetrazole and supramaximal electroshock-induced convulsions. In addition to protection against tonic convulsions, the animals were also protected against strychnine and pentetrazole lethality.
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis*; D000978:Antiparkinson Agents; D001463:Barbiturates / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D004357:Drug Synergism; D005260:Female; D006993:Hypnotics and Sedatives; D008297:Male; D051379:Mice; D011619:Psychotropic Drugs / Q000138:chemical synthesis*; D014508:Urea / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
D000927:Anticonvulsants; D000978:Antiparkinson Agents; D001463:Barbiturates; D006993:Hypnotics and Sedatives; D011619:Psychotropic Drugs; C028086:N-butyryl-N-butylurea; D014508:Urea