[Diuretic and saluretic effects of bemetizide and triamterene compared to those of their combination (author's transl)].
The diuretic and saluretic effect of the benzothiadiazine derivative 3-(a-methylbenzyl)-6-chlore-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-diozide (bemetizide) and the pteridine derivative 2,4,7-triamino-6-phenylpteridine (triamterene) were compared with those of their combination in the animal experiment on rats. Dose-effect relationships at a ratio of 1:2. The combination displayed marked advantages over the individual substances. The mixing proportion of 1:2 may be considered suitable.
D000818:Animals; D001581:Benzothiadiazines; D004231:Diuresis / Q000187:drug effects*; D004232:Diuretics; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004357:Drug Synergism; D005260:Female; D011188:Potassium / Q000652:urine; D051381:Rats; D012964:Sodium / Q000652:urine; D049993:Sodium Chloride Symporter Inhibitors / Q000494:pharmacology*; D014223:Triamterene / Q000008:administration & dosage / Q000494:pharmacology*
D001581:Benzothiadiazines; D004232:Diuretics; D004338:Drug Combinations; D049993:Sodium Chloride Symporter Inhibitors; D012964:Sodium; D011188:Potassium; D014223:Triamterene
Diuretische und saluretische Wirkung des Bemetizid und des Triamteren im Vergleich zu verschiendenen Kombinationen beider Substanzen