Time course of audiogenic seizure susceptibility and plasma pentobarbital concentration during withdrawal.
Rats were made dependent on sodium barbital by daily oral administration of the drug over a 4 week period. At the end of this time the animals were switched to sodium pentobarbital, I.P., 30 mg/Kg every 4 hours for 3 days and withdrawn. Mean Plasma pentobarbital concentrations was observed to decline rapidly following peak concentrations which occurred approximately 1 hour after the final dose. The last samples in which pentobarbital was detectable were taken 3 hours after the last dose. Audiogenic seizure susceptibility and intensity peaked at 6 hours following the last dose, suggesting that a low concentration of barbiturate is more important in increasing seizure propensity than a sudden decrease in concentration. No electroencephalographic abnormalities were observed during the withdrawal period.
D000161:Acoustic Stimulation; D000818:Animals; D004569:Electroencephalography; D006801:Humans; D008297:Male; D010424:Pentobarbital / Q000097:blood*; D051381:Rats; D012640:Seizures / Q000503:physiopathology*; D013375:Substance Withdrawal Syndrome / Q000097:blood / Q000503:physiopathology*; D013997:Time Factors
D010424:Pentobarbital