1,5-benzodiazepine derivatives with expected psychotropic activity.
By sulfuration of 4-methyl-1H-tetrahydro-1,5-benzodiazepinone-2 (1) its 2-thione 2 was synthesized. From this compound 2-hydrazone 3 and s-triazole derivatives 4 and 5 were obtained. Screening revealed that only compound 2 showed strong inhibitory activity in the spontaneous motility test, weak synergism with hexobarbital, weak antinflammatory activity in the carrageenin test and strong analgesic activity in the hot plate test.
D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D001569:Benzodiazepines / Q000494:pharmacology* / Q000633:toxicity; D004357:Drug Synergism; D006591:Hexobarbital / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects; D011619:Psychotropic Drugs; D051381:Rats; D013329:Structure-Activity Relationship
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D011619:Psychotropic Drugs; D001569:Benzodiazepines; D006591:Hexobarbital