[Teratogenic effect of N-phthaloyl-L-aspartic acid on the mouse (author's transl)].
The optical isomers of N-phthaloyl-aspartic acid, structurally related to thalidomide, were administered i.p. to pregnant mice on day 9 of gestation; the injected solutions contained Tween 20 as solubilizer. N-Phthaloyl-L-aspartic acid exerts an embryotoxic and teratogenic effect as is evident by the high incidence of resorption and malformations. On the other hand the D-isomer is devoid of any embryotoxic and teratogenic activity under the same conditions of experiment.
D000818:Animals; D001224:Aspartic Acid; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D010797:Phthalimides / Q000633:toxicity*; D011247:Pregnancy; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013723:Teratogens; D013792:Thalidomide / Q000031:analogs & derivatives
D010797:Phthalimides; D013723:Teratogens; D001224:Aspartic Acid; D013792:Thalidomide
Teratogene Wirkung von N-Phthalyl-L-asparaginsäure bei der Maus