title: Central anticholinergic effects of N-ethyl-2-pyrrolidylmethyl-cyclopentylphenyl glycollate.
abstract: The following effects of N-ethyl-2-pyrrolidyl-methyl-cyclopentylphenyl glycollate (PMCG) have been studied: effects on aggressive behaviour in mice and on general behaviour in rats, protective effects against central action of arecoline and nicotine in mice, thermo-regulatory effects in mice, protective action in poisonings with fluostigmine in mice and rats, and effects on bioelectrical activity of the brain in cats. It was stated that PMCG possesses a strong central anticholinergic activity blocking predominantly central muscarinic receptors; PMCG had also strong protective effects in anticholinesterase intoxications. It is suggested that this drug could have antiemotional and antiparkinsonian properties.
mesh_terms: D000374:Aggression / Q000187:drug effects; D000818:Animals; D001115:Arecoline / Q000037:antagonists & inhibitors; D001522:Behavior, Animal / Q000187:drug effects; D001833:Body Temperature Regulation / Q000187:drug effects; D001921:Brain / Q000187:drug effects; D003517:Cyclopentanes / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D009538:Nicotine / Q000037:antagonists & inhibitors; D010276:Parasympatholytics; D011759:Pyrrolidines / Q000494:pharmacology*; D051381:Rats
chemical_list: D003517:Cyclopentanes; D010276:Parasympatholytics; D011759:Pyrrolidines; D001115:Arecoline; D009538:Nicotine