[Phenols as toxic metabolites of benz(a)pyrene].
The effect of benzo(a)pyrene and two its phenolic metabolites 3-hydroxybenzo(a)-pyrene and 6-hydroxybenzo(a)pyrene--on the cultures of normal and transformed fibroblasts has been studied. In was shown that unlike the parent carcinogen its phenolic metabolites exerted only toxic (but not transforming) effect on cultured cells, and this effect has been developed at a faster rate than that produced by benzo(a)pyrene. 6-hydroxybenzo(a)pyrene was more toxic than 3-hydroxybenzo(a) pyrene. It was concluded that both metabolites produced their effects without preliminary activation by microsomal enzymes.
D000818:Animals; D001580:Benzopyrenes / Q000633:toxicity*; D002460:Cell Line; D002470:Cell Survival; D006224:Cricetinae; D004247:DNA / Q000096:biosynthesis; D005347:Fibroblasts; D007739:L Cells; D051379:Mice
D001580:Benzopyrenes; D004247:DNA
Fenoly kak toksicheskie metabolity benz(a)pirena.