title: Central and peripheral catecholamines and phenylethanolamine-N-methyl-transferase activity during the oestrus cycle.
abstract: Natural variations in monoamine levels in the adrenal gland, whole brain, hypothalamus and plasma during the oestrus cycle were determined in Sherman rats. Noradrenaline content of adrenal gland was at its highest level during met-oestrus phase while adrenaline was at its lowest level. During pro-oestrus adrenaline in the adrenal gland was at the maximum value. Plasma adrenaline did not change significantly during the oestrus cycle. However plasma noradrenaline was significantly higher during metoesrus compared to the value of di-oestrus and pro-oestrus. In the hypothalamus noradrenaline level was at its highest value during di-oestrus and at its lowest during met-oestrus, while brian noradrenaline reached its maximum value during pro-oestrus. The sum of plasma adrenaline and noradrenaline showed maximum level during met-oestrus phase but at the same time total adrenal adrenaline plus noradrenaline was lowered. The variations in adrenaline and noradrenaline in the adrenal gland did not correspond to the changes in the activity of enzyme, phenylethanolamine-N-methyltransferase (PNMT). The activity of PNMT reached its maximum value during met-oestrus phase of the oestrus cycle. The observed variations in adrenal, brain, hypothalamus and plasma catecholamines can be attributed to the modification in endocrine activity which takes place during the oestrus cycle.
mesh_terms: D000311:Adrenal Glands / Q000201:enzymology / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002395:Catecholamines / Q000378:metabolism*; D004837:Epinephrine / Q000097:blood; D004971:Estrus; D005260:Female; D009638:Norepinephrine / Q000097:blood; D010625:Phenylethanolamine N-Methyltransferase / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats
chemical_list: D002395:Catecholamines; D010625:Phenylethanolamine N-Methyltransferase; D009638:Norepinephrine; D004837:Epinephrine