[Clinical study on penetration of antibiotics into cerebrospinal fluid (second report),-Study on intravenous administration of sodium cephalothin with mannitol solution (author's transl)].
Penetration of Sodium Cephalothin (CET) into CSF follwing intravenous administration was studied in 23 patients with intracranial diseases excluding inflammation and severe subarachnoid hemorrhage. 1) After intravenous injection of 2 g of CET, ventricular CSF was obtained in 4 cases. All these 4 cases showed CET concentration in CSF to be below 0.1 mcg/ml. 2) After intravenous injection of 2 g of CET, lumbar CSF was obtained in 6 cases. In two cases out of these 6 cases, CET concentration in CSF was higher than 0.7 mcg/ml. 3) In 13 cases 2 g of CET with 200ml of 20% Mannitol was injected intravenously and lumbar CSF was examined. CET concentrations in CSF between 0.7 mcg/ml and 6.0 mcg/ml were observed in 9 cases of this group. 4) According to the results it is strongly suggested that the administration of Monnitol and CET is very effective for penetration of CET into CSF.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002512:Cephalothin / Q000008:administration & dosage* / Q000134:cerebrospinal fluid; D002648:Child; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D002532:Intracranial Aneurysm / Q000097:blood / Q000134:cerebrospinal fluid; D002538:Intracranial Arteriovenous Malformations / Q000097:blood / Q000134:cerebrospinal fluid; D002542:Intracranial Embolism and Thrombosis / Q000097:blood / Q000134:cerebrospinal fluid; D008297:Male; D008353:Mannitol / Q000008:administration & dosage*; D008875:Middle Aged
D004338:Drug Combinations; D008353:Mannitol; D002512:Cephalothin