title: [Toxicological investigation of reproterol (author's transl)].
abstract: Only slight toxicity of 7-(3-[2-(3,5-dihydroxyphenyl-2-hydroxy-ethylamino]-propyl)-theophylline (reproterol, Bronchospasmin) was shown in the examination of acute, subacute and chronic trials on various animal species with different modes of application. Slight side-effects noted with high toxically active dosages correspond with those of other well-known beta-sympathicomimetics. No influence on the pre-,peri- and postnatal development could be proven with doses tolerated by the parent animals.
mesh_terms: D000014:Abnormalities, Drug-Induced; D000284:Administration, Oral; D000336:Aerosols; D000818:Animals; D000831:Animals, Newborn; D001724:Birth Weight / Q000187:drug effects; D001993:Bronchodilator Agents / Q000633:toxicity; D004285:Dogs; D005260:Female; D005298:Fertility / Q000187:drug effects; D006128:Growth / Q000187:drug effects; D007275:Injections, Intravenous; D007928:Lethal Dose 50; D008297:Male; D010627:Phenethylamines / Q000008:administration & dosage / Q000633:toxicity*; D011247:Pregnancy; D011817:Rabbits; D051381:Rats; D014970:Xanthines / Q000008:administration & dosage / Q000633:toxicity*
chemical_list: D000336:Aerosols; D001993:Bronchodilator Agents; D010627:Phenethylamines; D014970:Xanthines
vernacular_title: Toxikologische Prüfung von Reproterol