Effect of propranolol on glycerol induced acute renal failure in rats.
The effect produced by propranolol, administered for a prolonged period of time and in large doses, on renal function in rats has been studied, as well as the modifications induced by this treatment in an experimental model of acute renal failure, and the effects of a single dose of propranolol given 1 hour before provoking failure. Propranolol, administered chronically, causes sodium and water retention and increases creatinine clearance. Acute renal failure induced by glycerol in rats treated for 7 days with propranolol is less severe than the one produced in untreated animals. In this ARF model, a single dose of propranolol does not seem to have a protective effect.
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000503:physiopathology; D000818:Animals; D003404:Creatinine / Q000032:analysis; D004231:Diuresis / Q000187:drug effects; D005260:Female; D005990:Glycerol; D007273:Injections, Intramuscular; D007678:Kidney Glomerulus / Q000187:drug effects*; D011188:Potassium / Q000032:analysis; D011433:Propranolol / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D012083:Renin / Q000378:metabolism; D012964:Sodium / Q000032:analysis; D014556:Urine / Q000032:analysis
D012964:Sodium; D011433:Propranolol; D003404:Creatinine; D012083:Renin; D005990:Glycerol; D011188:Potassium