[Results of a predictive trial of the response to nomifensine in ambulatory patients].
Nine hundred and fifty eight cases of neurotic-secondary ambulatory depression were treated with nomifensin by 135 psychiatrists. The analysis of visual analogue scales and of the global assessment shows that:--there were 2/3 responders and 1/3 non-responders--the most improved items were: crying, troubles in getting to sleep, abnormal tiredness, anxiety;--associated drugs from the beginning were frequent. They seemed to correspond to different initial symptomatologies but the final state did not differ substantially;--discrimination methods (linear discriminant function, stepwise discrimination) could separate groups of responders and non-responders, but did not allow for a valid individual prediction;--admist possible causes of these misclassifications, several factors are discussed: patient selection, choice of the variables, skewed or bimodal distributions, statistical methods used, acurateness of quotation, spectrum of the stutied drug.
D000275:Adjustment Disorders / Q000188:drug therapy; D000328:Adult; D000368:Aged; D000553:Ambulatory Care; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003863:Depression / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007546:Isoquinolines / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009627:Nomifensine / Q000627:therapeutic use*; D011379:Prognosis
D000928:Antidepressive Agents; D007546:Isoquinolines; D009627:Nomifensine
Résultats d'un essai prédictif de réponse à la nomifensine chez les malades ambulatoires.