Effect of morphine on 'wet-dog' shakes caused by cerebroventricular injection of serotonin.
Intraventricular administration of serotonin to rats causes 'wet-dog' shakes, a sign of morphine withdrawal. The frequency of shakes is dose-dependent. Shaking is potentiated by pretreatment with an inhibitor of monoamine oxidase or with 5,7-dihydroxytryptamine, and is depressed by morphine or serotonin receptor blockers. Depression of serotonin-induced shaking by morphine is reversed rapidly by naloxone. However, naloxone did not reverse the inhibition of 'wet-dog' shakes caused by serotonin receptor blockers.
D015116:5,7-Dihydroxytryptamine / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007276:Injections, Intraventricular; D008297:Male; D008803:Mianserin / Q000494:pharmacology; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D011985:Receptors, Serotonin / Q000187:drug effects; D012701:Serotonin / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D012702:Serotonin Antagonists; D013375:Substance Withdrawal Syndrome; D014191:Tranylcypromine / Q000494:pharmacology
D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D008803:Mianserin; D015116:5,7-Dihydroxytryptamine; D012701:Serotonin; D009270:Naloxone; D014191:Tranylcypromine; D009020:Morphine; D004298:Dopamine; D009638:Norepinephrine