[The action of 1-aminoadamantane. Comparative studies with isolated nerve endings and thrombocytes on the release of serotonin and dopamine].
Nerve endings isolated from rat brain accumulate exogenous serotonin and dopamine. Both biogenic amines are released from nerve endings as well by means of electrical stimulation with rectangular pulses of alternating polarity as by incubation with 5 X 10(-4) to 5 X 10(-5) M solutions of the adamantane derivatives 1-aminoadamantane hydrochloride (D 1) and 1-amino-3,5-dimethyladamantane hydrochloride (memantine, D 145). The electrically stimulated liberation is small but is significantly increased after simultaneous incubation of the nerve endings with subthreshold concentrations of 1-aminoadamantanes (5X10(-6) to 5X10(-5) M). The reuptake of released serotonin is noncompetitively inhibited by 1-aminoadamantanes. Also in blood platelets frequently used as model cells of the nerve endings the serotonin uptake is inhibited by small concentrations of D 145, 10(-5) to 2X10(-4) M. High concentrations of D 145- greater than 2X10(-3) M, induce the "release-reaction", the simultaneous liberation of serotonin, ATP, and ADP. In the concentration range of 2X10(-4) to 2X10(-3) M D 145 only serotonin is set free.
D000547:Amantadine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000818:Animals; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D003864:Depression, Chemical; D004298:Dopamine / Q000097:blood / Q000378:metabolism*; D004558:Electric Stimulation; D006801:Humans; D066298:In Vitro Techniques; D008559:Memantine / Q000494:pharmacology*; D009411:Nerve Endings / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D012701:Serotonin / Q000097:blood / Q000378:metabolism*
D012701:Serotonin; D000547:Amantadine; D004298:Dopamine; D008559:Memantine
Zur Wirkung der 1-Aminoadamantane. Vergleichende Untersuchungen an isolierten Nervenendigungen und Thrombozyten zur Freisetzung von Serotonin and Dopamin.