Influence of cortisone and cyclophosphamide on xanthine oxidase bacterial activation.
The xanthine oxidase increase in mice liver as response to infection was studied as a possible parameter useful for a better understanding of theimmunosuppression due to cyclophosphamide and cortisone. An impact of cortisone but not of cyclophosphamide on this mechanism was found; this may be useful in order to discriminate between the two different types of immunosuppressive drugs.
D000818:Animals; D001424:Bacterial Infections / Q000201:enzymology* / Q000276:immunology / Q000503:physiopathology; D003348:Cortisone / Q000494:pharmacology*; D003520:Cyclophosphamide / Q000494:pharmacology*; D004789:Enzyme Activation / Q000187:drug effects; D007166:Immunosuppressive Agents; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D051379:Mice; D013997:Time Factors; D014969:Xanthine Oxidase / Q000378:metabolism*
D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D014969:Xanthine Oxidase; D003348:Cortisone