Failure of a "prophylactic" antimicrobial drug to prevent sepsis after fiberoptic bronchoscopy.
A 53-year-old patient with lymphoblastic lymphoma developed progressive interstitial pulmonary infiltrates. The patient was believed to have Pseudomonas bronchitis and was given parenteral gentamicin. Transbronchial lung biopsy performed through a fiberoptic bronchoscope was complicated by the development of Pseudomonas septicemia. The organism isolated on blood culture, like the one isolated on sputum culture, was fully susceptible to gentamicin in vitro. A prophylactic antimicrobial drug did not prevent bacteremic Pseudomonas infection in our immunosuppressed patient with pre-existent Pseudomonas bronchitis.
D001991:Bronchitis / Q000188:drug therapy; D001999:Bronchoscopy / Q000009:adverse effects*; D005839:Gentamicins / Q000008:administration & dosage*; D006801:Humans; D007165:Immunosuppression Therapy; D008175:Lung Neoplasms / Q000150:complications; D008228:Lymphoma, Non-Hodgkin / Q000150:complications; D008297:Male; D008875:Middle Aged; D011292:Premedication; D011552:Pseudomonas Infections / Q000188:drug therapy / Q000517:prevention & control*; D018805:Sepsis / Q000517:prevention & control*
D005839:Gentamicins