[Sulpiride and the effect of dopamine on the kidney in human salt retention].
Experiments were performed to investigate the renal interaction between dopamine (DA) and sulpiride (S), an antagonistic drug for the central dopaminic receptors. DA was infused at a subpressor rate (0,1 microgram/kg . min) during induced hypotonic polyuria. In 8 healthy subjects in a condition of salt retention (DOCA pretreatment) two successive studies were carried out in the presence and in the absence of S. The drug treatment was started two days before the experiment. BOth the renal response to hydration and the renal effects of DA are modified by S treatment. 1) S enhances the hydro-saluretic effect produced by hydration. 2) During the early period of DA infusion, S counteracts the increase DA-induced in renal plasma flow. However the inhibitory tubular effects and the increase in the hydro-saluresis produced by DA are not significantly different from those observed in the absence of the drug.
D000328:Adult; D003900:Desoxycorticosterone; D004298:Dopamine / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007668:Kidney / Q000098:blood supply / Q000187:drug effects* / Q000378:metabolism; D011141:Polyuria / Q000139:chemically induced; D011954:Receptors, Dopamine / Q000187:drug effects; D012039:Regional Blood Flow / Q000187:drug effects; D012964:Sodium / Q000378:metabolism; D012965:Sodium Chloride / Q000652:urine*; D013469:Sulpiride / Q000494:pharmacology*
D011954:Receptors, Dopamine; D003900:Desoxycorticosterone; D012965:Sodium Chloride; D013469:Sulpiride; D012964:Sodium; D004298:Dopamine
Sulpiride e azione renale della dopamina nell'uomo in ritenzione idro-salina.