title: The mechanism of group differences in the character of the vaccinal process in immunization against natural smallpox.
abstract: The effect of antigenic polymorphism of the ABO-system blood groups on the character of the vaccinal process after immunization against natural smallpox was investigated. The increased susceptibility of persons possessing A antigen to the harmful effect of smallpox vaccine virus is due to hereditary rather than to acquired factors. The leukocytes of peripheral blood of these persons showed a poorer binding capacity with respect to the smallpoxvaccine virus; they also exhibited a high rate of chromosomal aberration after vaccination, resulting to some extent from increased proliferative ability of the cells.
mesh_terms: D000017:ABO Blood-Group System; D000293:Adolescent; D002648:Child; D006801:Humans; D007114:Immunization; D007223:Infant; D007518:Isoantibodies / Q000096:biosynthesis; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology; D012899:Smallpox / Q000235:genetics / Q000517:prevention & control*; D012900:Smallpox Vaccine / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D000017:ABO Blood-Group System; D007518:Isoantibodies; D012900:Smallpox Vaccine