Platelet hyporesponsiveness to epinephrine in carriers of Bartter's syndrome.
Platelet aggregation was investigated in the parents of 4 patients with Bartter's syndrome. Aggregation induced by ADP and ristocetin was normal. However, there was some depression of aggregation induced by collagen. All obligatory heterozygotes showed depressed aggregation in response to epinephrine.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D001477:Bartter Syndrome / Q000097:blood* / Q000235:genetics; D004837:Epinephrine / Q000494:pharmacology*; D006579:Heterozygote; D006801:Humans; D006929:Hyperaldosteronism / Q000097:blood*; D010974:Platelet Aggregation / Q000187:drug effects*; D012310:Ristocetin / Q000494:pharmacology
D012310:Ristocetin; D000244:Adenosine Diphosphate; D004837:Epinephrine