[Effect of inhibitors of nucleic synthesis on induction of the secondary immunologic response in vitro].
The authors studied the influence of the DNA and RNA inhibitors on the formation of antibody-forming cell populations in induction of a secondary immunological response in vitro. Low concentrations of cytosine-arabinoside, the DNA synthesis inhibitor, increased the count of indirect hemolysin-forming and rosette-forming cells; its high concentrations depressed the secondary immunological response induction in the direct hemolysin-forming cell system more intensively than in the indirect cell system. Actinomycin D depressed the stimulation of secondary immunological response in vitro both in the systems of direct and indirect hemolysin-forming, and of rosette-forming cells.
D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects; D003561:Cytarabine / Q000494:pharmacology*; D003609:Dactinomycin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006460:Hemolysin Proteins / Q000096:biosynthesis; D007104:Immune Adherence Reaction; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D007156:Immunologic Memory / Q000187:drug effects*; D066298:In Vitro Techniques; D051379:Mice
D006460:Hemolysin Proteins; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D003561:Cytarabine; D003609:Dactinomycin
Vliianie ingibitorov nukleinovogo sinteza na induktsiiu vtorichnogo immunologicheskogo otveta in vitro.