Balanced reciprocal whole-arm translocation t(1;19) in three generations.
Seven carriers of a balanced reciprocal whole-arm translocation of chromosomes 1 and 19 were found in 19 members investigated in three generations of one family. The apparent lack of a carrier of an unbalanced form of the translocation and of a history of miscarriages are discussed.
D000022:Abortion, Spontaneous / Q000453:epidemiology; D000328:Adult; D002900:Chromosomes, Human, 1-3; D002903:Chromosomes, Human, 19-20; D005260:Female; D006801:Humans; D008297:Male; D010375:Pedigree; D011247:Pregnancy; D014178:Translocation, Genetic