title: Effect of acute and chronic ethanol intake on metastasis formation in rat liver.
abstract: The effect of acute ethanol intoxication and prolonged intake of ethanol on metastasis formation in the liver was studied in the rat. The tumour cells used were derived from a pharmacologically induced colon carcinoma (NGW 1) and were injected intraportally. Acute ethanol intoxication at the time of injection was associated with a liver weight of 13.29 +/- 0.89 gm two weeks later, compared to 8.43 +/- 0.51 gm in controls. Daily intake of ethanol for eight weeks resulted in a mild reduction of platelets. The liver weight in two groups was 7.31 +/- 0.50 gm and 12.19 +/- 1.40 gm three weeks after intraportal injection of cancer cells as compared to 9.53 +/- 1.11 gm and 19.63 +/- 1.67 gm in controls. The results indirectly supported the hypothesis that acute ethanol intoxication causes increased platelet activity and confirmed earlier results showing the importance of platelets for metastasis formation.
mesh_terms: D000435:Alcoholic Intoxication / Q000150:complications*; D000818:Animals; D000431:Ethanol; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000139:chemically induced*; D008297:Male; D009362:Neoplasm Metastasis; D009374:Neoplasms, Experimental / Q000139:chemically induced; D010976:Platelet Count; D051381:Rats; D011920:Rats, Inbred WF
chemical_list: D000431:Ethanol