Influence of ethanol and dexamethasone on blood-brain barrier dysfunction to albumin.
Stab-wounded ethanol-intoxicated and non-intoxicated rats were studied with respect to the effect of postoperative dexamethasone treatment on blood-brain barrier dysfunction to bovine albumin. In ethanol-intoxicated rats, fluorescence microscopy revealed an increased area of extravasation of fluorescent tracer, compared to non-intoxicated ones. No significant effect of dexamethasone treatment was observed in non-intoxicated rats. In ethanol-intoxicated rats, dexamethasone treatment resulted in a decreased area of extravasation. Quantitative immuno-electrophoretic measurements of exogeneous bovine albumin confirmed a significant decrease of blood-brain barrier dysfunction to albumin after dexamethasone treatment in ethanol-intoxicated rats, while no significant effect was observed in non-intoxicated ones.
D000435:Alcoholic Intoxication / Q000503:physiopathology*; D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects*; D003907:Dexamethasone / Q000494:pharmacology*; D000431:Ethanol / Q000494:pharmacology*; D006801:Humans; D007122:Immunoelectrophoresis; D046911:Macromolecular Substances; D008297:Male; D008856:Microscopy, Fluorescence; D051381:Rats; D012711:Serum Albumin, Radio-Iodinated
D046911:Macromolecular Substances; D012711:Serum Albumin, Radio-Iodinated; D000431:Ethanol; D003907:Dexamethasone