Protective effects of a novel thromboxane analog in lethal traumatic shock.
Pinane thromboxane A2 (PTA2) an analog of thromboxane A2 that inhibits the formation of thromboxanes as well as antagonizes their biological actions, at an infusion rate of 1.0 mumole . kg-1 . h-1, prolonged survival in traumatic shock in rats. PTA2 also prevented the accumulation of thromboxane B2, the lysosomal protease, cathepsin D, and the cardiotoxic peptide MDF in the circulating blood.
D000818:Animals; D000081008:Bicyclic Monoterpenes; D002403:Cathepsins / Q000097:blood; D009201:Myocardial Depressant Factor / Q000097:blood; D051381:Rats; D012774:Shock, Traumatic / Q000097:blood / Q000188:drug therapy*; D013928:Thromboxane A2 / Q000031:analogs & derivatives / Q000627:therapeutic use*; D013929:Thromboxane B2 / Q000097:blood; D013931:Thromboxanes / Q000037:antagonists & inhibitors / Q000627:therapeutic use*
D000081008:Bicyclic Monoterpenes; D009201:Myocardial Depressant Factor; D013931:Thromboxanes; D013929:Thromboxane B2; D013928:Thromboxane A2; C020465:pinane-thromboxane A2; D002403:Cathepsins