[Lipids and phospholipids in the fluid of broncho-alveolar lavage. Value for the study of alveolar penetration of corticosteroids by aerosol (author's transl)].
Broncho-alveolar lavages from 13 control subjects have been studied for the following parameters : phospholipids, free fatty acids, total last parameter, through the depolarisation of Diphenylhexatriene, is independent of the recovered volume. An identical study has been performed for two bronchiolo-alveolar cancers. A treatment with hydrocortisone-containing aerosol has been associated with an increase in phospholipid amount and a drastic decrease in microviscosity. This observation suggests that the synthesis of tensio-active phospholipids is dependant of corticoids by an enzymatic induction. The effect of therapeutics given in aerosol can be monitored by the biochemical and physical modification in broncho-alveolar fluids thus obtained.
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000336:Aerosols; D001980:Bronchi; D005260:Female; D006801:Humans; D008055:Lipids; D008168:Lung / Q000187:drug effects; D010743:Phospholipids; D007507:Therapeutic Irrigation
D000305:Adrenal Cortex Hormones; D000336:Aerosols; D008055:Lipids; D010743:Phospholipids
Les lipides et phospholipides du liquide de lavage broncho-alvéolaire : intérêt dans l'étude de la pénétration alvéolaire des corticoïdes par aérosol.