Effect of metabolic inhibitors on growth and brefeldin A formation in Curvularia lunata.
Arsenite as opposed to azide exerted a stronger inhibitory effect on brefeldin A production than on mycelial growth of cultures of Curvularia lunata. However, azide was a more potent inhibitor of mycelial growth than arsenite at 0.5 mM and 1.0 mM. The inhibitory effects of iodoacetate on growth and brefeldin A formation were significantly less potent than those of iosoacetamide. Increases in the levels of fluoride elicited a variable inhibitory effect on brefeldin A production and a corresponding decrease in biomass.
D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D000963:Antimetabolites / Q000494:pharmacology*; D001151:Arsenic / Q000494:pharmacology; D001386:Azides / Q000494:pharmacology; D003517:Cyclopentanes / Q000096:biosynthesis; D005459:Fluorides / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism; D007460:Iodoacetamide / Q000494:pharmacology; D007461:Iodoacetates / Q000494:pharmacology; D003904:Mitosporic Fungi / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism
D000900:Anti-Bacterial Agents; D000963:Antimetabolites; D001386:Azides; D003517:Cyclopentanes; D007461:Iodoacetates; D005947:Glucose; D001151:Arsenic; D005459:Fluorides; D007460:Iodoacetamide