Effects of cycloheximide on protein synthesis in human lung tumors, regenerating rat liver and hepatomas.
10(-4) M cycloheximide (CHM) inhibits leucine incorporation to about the same degree in slices of human lung tumors, rat hepatomas, regenerating livers and normal tissues. At 10(-6) M, CHM has a more pronounced effect on tumor tissue and regenerating liver than on normal tissues. 10(-8) M CHM stimulates protein synthesis in normal rat liver slices.
D000818:Animals; D003513:Cycloheximide / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008114:Liver Neoplasms, Experimental / Q000378:metabolism; D008115:Liver Regeneration; D008175:Lung Neoplasms / Q000378:metabolism; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D009374:Neoplasms, Experimental / Q000378:metabolism*; D014176:Protein Biosynthesis
D009363:Neoplasm Proteins; D003513:Cycloheximide