Transfer of alpha-tocopherol from plasma to erythrocytes in vitamin E-deficient rats.
The transfer of alpha-tocopherol from plasma to erythrocytes was examined using labeled alpha-tocopherol in vitamin E-deficient rats and at the same time the appearance of resistance to dialuric acid-induced hemolysis in the erythrocytes was observed. It was noticed that the transfer took place in two sequential steps. The second step seemed to correlate the appearance of resistance to dialuric acid-induced hemolysis, d-alpha and d,l-alpha-Tocopherol were compared under the same in vitro experimental conditions and no difference between them was observed in the effect on the recovery of antihemolytic activity. The difference in physiological activity between d-alpha- and d,l-alpha-tocopherol may exist other than in the transfer step. The coexistence of alpha-tocopherol and alpha-tocopherol quinone did not show any inhibiton for transfer of alpha-tocopherol from plasma to erythrocytes in vitamin E-deficient rats.
D000818:Animals; D001692:Biological Transport; D004912:Erythrocytes / Q000378:metabolism*; D007700:Kinetics; D051381:Rats; D014316:Tritium; D014810:Vitamin E / Q000097:blood*; D014811:Vitamin E Deficiency / Q000097:blood*
D014316:Tritium; D014810:Vitamin E