An experimental approach to the breast cancer, reserpine problem.
Reserpine was administered intraperitoneally 3 times weekly to inbred female Syrian BIO hamsters of the 15.16 strain previously shown to be susceptible to methylcholanthrene (MC) induction of mammary cancer. Other groups of hamsters received non-carcinogenic doses of MC along with the reserpine administrations, and an additional group received a carcinogenic dose of MC alone. This last group demonstrated that BIO 15.6 females were indeed susceptible to MC mammary cancer induction, since 4 mg of MC administered by stomach tube (a total dose of 200 mg) caused mammary cancer in 52% of the animals. Mammary cancer was not observed in any of the animals given reserpine or reserpine in combination with the non-carcinogenic dose of MC.
D000818:Animals; D002273:Carcinogens; D006224:Cricetinae; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced*; D008647:Mesocricetus; D008748:Methylcholanthrene / Q000008:administration & dosage; D051379:Mice; D012110:Reserpine / Q000008:administration & dosage / Q000633:toxicity*
D002273:Carcinogens; D008748:Methylcholanthrene; D012110:Reserpine