[Role of estrogen-sensitive neurons in the arcuate region of the hypothalamus in the mechanism of luteinizing hormone release].
Experiments were conducted on rats; estradiol brought to the arcuate region of the hypothalamus by means of microionophoresis led to the increase of the region of the hypothalamus by means of microionophoresis led to the increase of the blood luteinizing hormone (LH) level during the following stages of the estral cycle-diestrus 1, diestrus 2, and the first half day of the proestrus; as to the second half of the proestrus day--estradiol decreased its level. Changes in the LH level in the hypophysis under the influence of the microionophoretic introduction of estradiol into the arcuate region occurred during the second half of the day of diestrus 2 (reduction), and during the estrus (elevation). In the majority of cases a rise of the blood level was combined with the neuron activation in the arcuate region under the influence of estradiol.
D000818:Animals; D004031:Diestrus / Q000187:drug effects; D004958:Estradiol / Q000494:pharmacology; D004971:Estrus / Q000187:drug effects; D005260:Female; D007031:Hypothalamus / Q000187:drug effects*; D007478:Iontophoresis; D007986:Luteinizing Hormone / Q000097:blood*; D009474:Neurons / Q000187:drug effects*; D010902:Pituitary Gland / Q000187:drug effects; D011247:Pregnancy; D011359:Proestrus / Q000187:drug effects; D051381:Rats; D011960:Receptors, Estrogen / Q000187:drug effects*
D011960:Receptors, Estrogen; D004958:Estradiol; D007986:Luteinizing Hormone
Rol' éstrogenchuvstvitel'nykh neĭronov arkuatnoĭ oblasti gipotalamusa v mekhanizme osvobozhdeniia liuteiniziruiushchego gormona.