Pulmonary circulatory adaptation to acute atelectasis in man.
Pulmonary functional veno-arterial shunt determinations were made breathing 100% oxygen in thirty consecutive patients during thoracotomy with one-lung anesthesia. Initially, with both lungs ventilated (FiO2 100%), the mean shunt value was 18.1 +/- 1.2% (S.D.). With the collapse of one lung by deflation and surgical pneumothorax, the shunt rose to 36.0 +/- 1.5%. With time the value fell: 36.0 +/- 1.5% at five minutes, 30.3 +/- 1.4% at fifteen minutes, 30.3 +/- 1.4% at thirty minutes, 28.1 +/- 1.4% at sixty minutes, and 24.6 +/- 2.8% after two hours. This trend was significant at a p value of less than 0.001. This study for the first time documents in man the phenomenon of pulmonary circulatory adaptation to acute atelectasis.
D000208:Acute Disease; D001166:Arteriovenous Shunt, Surgical; D002302:Cardiac Output; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000601:surgery; D010100:Oxygen / Q000097:blood; D011031:Pneumothorax, Artificial; D001261:Pulmonary Atelectasis / Q000150:complications / Q000503:physiopathology*; D011652:Pulmonary Circulation; D012119:Respiration
D010100:Oxygen