title: [Changes in neurons of a spinal ganglion culture during chronic exposure to increasing concentrations of morphine].
abstract: On the model of spinal ganglion cultures in mice by means of a light and electron microscopy the authors studied neuron changes in chronic influence of increasing concentrations of morphine. These studies demonstrated changes in most of the cytoplasmatic organells: changes in the granular and agranular reticulum; an appearance of a large amount of small vesicles in the cytoplasma and lysosome; changes of the mitochondria (partial vacuolization of the crysts and appearance of a big amount of small mitochondria); a large amount of myelin-like structures; changes of the nuclear membranes; nucleoli and an increased amount of ribosomes.
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D004721:Endoplasmic Reticulum / Q000187:drug effects; D005727:Ganglia, Spinal / Q000196:embryology; D006056:Golgi Apparatus / Q000187:drug effects; D051379:Mice; D008854:Microscopy, Electron; D008928:Mitochondria / Q000187:drug effects; D009020:Morphine / Q000008:administration & dosage*; D009474:Neurons / Q000187:drug effects* / Q000648:ultrastructure
chemical_list: D009020:Morphine
vernacular_title: Izmeneniia neĭronov kul'tury spinal'nykh gangliev pri khronicheskom vozdeĭstvii vozrastaiushchikh kontsentratsiĭ morfina.