Testicular tumors in infants and children.
Forty three children with testicular tumors have been presented. Eighty per cent of these tumors were malignant, and 60 per cent occurred in children less than two and one half years of age. Twenty of the 24 malignant germinal tumors were embryonal cell carcinomas. The mean age of the patients at presentation of these tumors was 18 months. Nine patients underwent orchiectomy alone, and five of these have died. Eleven received combined therapy, and all have survived. We currently recommend radical orchiectomy and extended unilateral retroperitoneal lymphadenectomy. If examination of the nodes reveals evidence of metastases, a bilateral dissection is done. Radiotherapy is given only in the presence of nodal metastases. Adjuvant chemotherapy with vincristine, actinomycin D, and Cytoxan is given for two years to all patients with malginant nonseminomatous germ cell tumors or sarcomas.
D000293:Adolescent; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D002822:Choriocarcinoma / Q000628:therapy; D004359:Drug Therapy, Combination; D006801:Humans; D007223:Infant; D007984:Leydig Cell Tumor / Q000628:therapy; D008197:Lymph Node Excision; D008297:Male; D012509:Sarcoma / Q000628:therapy; D013724:Teratoma / Q000628:therapy; D013736:Testicular Neoplasms / Q000628:therapy*
D000970:Antineoplastic Agents