Rotational behavior induced in rats by intranigral application of GABA-related drugs and GABA antagonists.
GABA and GABA-related drugs such as muscimol, gamma-hydroxybutyric acid and baclofen injected unilaterally into the substantia nigra of rats elicited contraversive turning. Unilateral injections of picrotoxin and bicuculline produced either ipsi- or contraversive turning depending on the volume of vehicle. I.p. applied haloperidol did not abolish the muscimol-induced turning. This and the direction of rotational behavior suggests that the turning behavior elicited by GABA-related drugs is not mediated by the nigrostriatal dopaminergic tract.
D000613:Aminobutyrates / Q000494:pharmacology*; D000818:Animals; D001519:Behavior / Q000187:drug effects*; D018756:GABA Antagonists; D006801:Humans; D007267:Injections; D008297:Male; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects*; D013378:Substantia Nigra; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology*
D000613:Aminobutyrates; D018756:GABA Antagonists; D005680:gamma-Aminobutyric Acid