A reflection on the oxygen diffusion of the terminal villus of the human placenta (author's transl).
By using a simple model, transformed to cartesian coordinates, we examined the behavior of the fetal and maternal oxygen partial pressure on the terminal villus of the human placenta during a constant arteriovenous oxygen difference. For this purpose we divided the flow length of the cotyledon in central and a peripheral part. We found that the oxygen exchange takes place at a lower utero-umbilical oxygen pressure gradient it the reduction of the maternal blood flow velocity amounts to 30% of the normal value and if the diffusion distance is doubled. However under these circumstances a sufficient the oxygen supply of the fetal organism. This is the case with the total flow length of a single cotyledon, but some of the terminal villi in the periphery of the cotyledon, could receive at the same time a diminished oxygen supply leading to degenerative cell changes. At a progression of these morphological changes or during labor the oxygen transport can get insufficient.
D002824:Chorionic Villi / Q000378:metabolism* / Q000648:ultrastructure; D005260:Female; D005333:Fetus / Q000502:physiology; D006801:Humans; D008855:Microscopy, Electron, Scanning; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption; D010313:Partial Pressure; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D012039:Regional Blood Flow
D010100:Oxygen
Eine Betrachtung zur Sauerstoffdiffusion an der Terminalzotte der menschlichen Plazenta.