Imidazo[4,5-f]quinolines. 4. Synthesis and anthelmintic activity of a series of imidazo[4,5-f]quinolin-9-ols.
A series of 2-arylimidazo[4,5-f]quinolin-9-ols has been prepared by a multistep procedure from various 5-aminobenzimidazoles. These compounds possess a significant degree of anthelmintic activity against the mouse tapeworm Hymenolepis nana. The most active compound is the 2-(2-furyl) analogue. Additional anthelmintic testing is reported for this compound.
D000818:Animals; D000871:Anthelmintics / Q000138:chemical synthesis; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D006912:Hydroxyquinolines / Q000138:chemical synthesis / Q000627:therapeutic use*; D007093:Imidazoles / Q000138:chemical synthesis / Q000627:therapeutic use*; D051379:Mice; D008989:Monieziasis / Q000188:drug therapy; D009349:Nematode Infections / Q000188:drug therapy; D010124:Oxyuroidea; D012756:Sheep; D013622:Taeniasis / Q000188:drug therapy*
D000871:Anthelmintics; D006912:Hydroxyquinolines; D007093:Imidazoles