Mesangiolytic glomerulonephritis in an infant with immune deficiency and echovirus infection.
An unusual glomerulonephritis characterized by diffuse mesangial cell necrosis and lysis of mesangial areas was observed in a male infant who had a combined immune deficiency and systemic echovirus type 6 infection. The occurrence of glomerular disease in a patient with combined immune deficiency indicates that the glomerular injury can be inflicted without mediation of immune mechanisms, presumably by direct cytopathic effect of echovirus 6.
D004458:Echovirus 6, Human; D004457:Echovirus Infections / Q000150:complications*; D005921:Glomerulonephritis / Q000150:complications* / Q000473:pathology; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications*; D007223:Infant; D007678:Kidney Glomerulus / Q000473:pathology*; D008297:Male; D009336:Necrosis / Q000473:pathology