Short- and long-term effects of intraventricular 6-hydroxydopamine in rats pretreated with a monoamine oxidase inhibitor.
Bilateral intraventricular injections of high dose (2 X 250 microgram) of 6-hydroxydopamine to rats pretreated with nialamide produced a pronounced hyperactivity persisting for several hours and induced permanent aggressiveness. Only 50% rat survived the treatment for longer than a week, the explorative activity of the survivors was inhibited for over 2 months. The brain catecholamine content was depressed for at least 15 months, while no long-term changes of serotonin level were observed. The hyperactivity, aggressiveness and hypothermia produced by apomorphine were enhanced in centrally chemosympathectomized rats, while the hyperactivity produced by D-amphetamine or amantadine remained inaffected. The results confirm the development of dopamine receptor supersensitivity following central chemosympathectomy, and indicate a possibility of employing the supersensitivity model for distinguishing between pre- and postsynaptic action of dopaminergic stimulants.
D000374:Aggression / Q000187:drug effects; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001679:Biogenic Amines / Q000378:metabolism; D001831:Body Temperature / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects; D004347:Drug Interactions; D005106:Exploratory Behavior / Q000187:drug effects; D006801:Humans; D006892:Hydroxydopamines / Q000008:administration & dosage / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009526:Nialamide / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D001679:Biogenic Amines; D006892:Hydroxydopamines; D009526:Nialamide