Phenytoin hepatotoxicity: a case report and review.
A 17-year-old woman with phenytoin-induced hepatotoxicity was compared with 23 other cases from the literature. Hepatic injury caused by phenytoin is rare but important because of its significant morbidity and mortality. A typical multisystem clinical pattern precedes the manifestations of hepatic dysfunction. Pathologic findings indicate a mixed hepatocellular damage of cholestasis and necrosis. Pathogenic mechanisms are unexplained, but a delayed hypersensitivity reaction appears likely.
D000293:Adolescent; D000328:Adult; D000368:Aged; D056486:Chemical and Drug Induced Liver Injury; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008107:Liver Diseases / Q000628:therapy; D008875:Middle Aged; D010672:Phenytoin / Q000633:toxicity*
D010672:Phenytoin