Amphotericin B and 5-fluorocytosine penetration into blood and fibrin clots.
The fungicidal effect of amphotericin B and 5-fluorocytosine (5-FC) on fungi incorporated into blood and fibrin clots was investigated. Amphotericin B was ineffective against fungi incorporated into blood clots, but effective in the eradication of fungi in fibrin clots. 5-FC was ineffective both against fungi incorporated in blood clots as well as in fibrin clots. The combination of 5-FC and amphotericin B was likewise ineffective against fungi incorporated into blood clots. The failure of these drugs to penetrate blood clots may explain the treatment failure in fungal endocarditis.
D000666:Amphotericin B / Q000494:pharmacology*; D001769:Blood / Q000382:microbiology*; D001792:Blood Platelets; D002175:Candida / Q000187:drug effects*; D003596:Cytosine / Q000031:analogs & derivatives*; D004617:Embolism / Q000382:microbiology*; D004697:Endocarditis, Bacterial / Q000188:drug therapy; D005337:Fibrin; D005437:Flucytosine / Q000494:pharmacology*; D006801:Humans; D008954:Models, Biological
D000666:Amphotericin B; D003596:Cytosine; D005337:Fibrin; D005437:Flucytosine