Sicca complex and cholangiostatic jaundice in two members of a family probably caused by thiabendazole.
An entire family (father, mother, and three daughters) were given thiabendazole because one of the children had acquired pinworm infestation. The mother and one daughter (non-infected) developed a sicca complex (keratoconjunctivitis sicca and xerostomia) accompanied by cholangiostatic jaundice. Sjögren's syndrome is an autoimmune disease and presents many immune mechanism aberrancies. An association between autoimmune liver disease and sicca complex has been reported. Labeled mitochondrial antibodies bound to the parotid duct have been noted in patients with autoimmune cholangiostatic jaundice and such antibodies may be similar to the antibody against salivary duct found in Sjögren's syndrome. It is suggested that in these two patients, thiabendazole may have acted as a hapten and by binding to the body protein induced the production of autoantibodies which may have acted against the biliary epithelium, the salivary duct epithelium, and the lacrimal gland ducts.
D000293:Adolescent; D000328:Adult; D001323:Autoantibodies; D001327:Autoimmune Diseases / Q000209:etiology; D002648:Child; D002779:Cholestasis / Q000139:chemically induced*; D004757:Enterobius; D005260:Female; D006801:Humans; D007637:Keratoconjunctivitis / Q000139:chemically induced*; D008297:Male; D010123:Oxyuriasis / Q000188:drug therapy; D012859:Sjogren's Syndrome / Q000139:chemically induced* / Q000276:immunology; D013827:Thiabendazole / Q000009:adverse effects* / Q000276:immunology / Q000627:therapeutic use; D014987:Xerostomia / Q000139:chemically induced*
D001323:Autoantibodies; D013827:Thiabendazole