Reduction of bladder contractility after alpha-adrenergic blockade and after ganglionic blockade.
Seven spinal cord injured patients were evaluated with cystometry bladder, electromyography, and pressure profiles  of the external urethral sphincter before and after phenoxybenzamine administration. Seven more patients were evaluated before and after mecamylamine administration. Both drugs reduced the contractility of the bladder. The reduction of bladder contractility may reflect decreased sympathetic stimulation to the bladder. Bladder electric potentials reflect the intrinsic tone of the detrusor muscle.
D000328:Adult; D001285:Atropine / Q000494:pharmacology*; D005725:Ganglia, Autonomic / Q000187:drug effects*; D006801:Humans; D008297:Male; D008464:Mecamylamine / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects; D010643:Phenoxybenzamine / Q000494:pharmacology*; D011312:Pressure; D013119:Spinal Cord Injuries / Q000503:physiopathology; D014521:Urethra / Q000187:drug effects; D001743:Urinary Bladder / Q000187:drug effects* / Q000294:innervation; D001750:Urinary Bladder, Neurogenic / Q000503:physiopathology*
D010643:Phenoxybenzamine; D008464:Mecamylamine; D001285:Atropine