[Vinblastine-loaded platelets and their effect in a case of idiopathic thrombocytopenic purpura (author's transl)].
The successful treatment of a patient with idiopathic thrombocytopenia (ITP) by vinblastine-loaded platelets (VMT) is described. Serum autoantibodies and platelet-bound IgG disappeared after treatment. We infer that this type of therapy does not oeprate on the level of platelet destroying cells but rather affects antibody producing cells. Since there was also a T-cell sensitization versus VMT we favour the hypothesis of a modified self alteration as the cause of the disease and its recovery of VMT.
D000293:Adolescent; D001323:Autoantibodies / Q000032:analysis; D001792:Blood Platelets / Q000276:immunology; D001803:Blood Transfusion; D001804:Blood Transfusion, Autologous; D006801:Humans; D008297:Male; D011241:Prednisone / Q000627:therapeutic use; D011696:Purpura, Thrombocytopenic / Q000628:therapy*; D013156:Splenectomy; D014747:Vinblastine / Q000627:therapeutic use
D001323:Autoantibodies; D014747:Vinblastine; D011241:Prednisone
Die Wirkung von Vinblastin-beladenen Thrombozyten im Fall einer idiopathischen thrombozytopenischen Purpura.