Chemotactic responses of tumor cells to products of resorbing bone.
To explore possible mechanisms for the metastasis of malignant cells to bone, a model of tumor cell migration was developed, using Walker carcinosarcoma or malignant lymphoma cells. It was found that bone contains a factor that is strongly chemotactic for tumor cells. This factoor is released by a variety of agents that induce resorption of bone.
D000818:Animals; D001862:Bone Resorption / Q000503:physiopathology*; D001842:Bone and Bones / Q000503:physiopathology*; D002279:Carcinoma 256, Walker / Q000503:physiopathology*; D002460:Cell Line; D002465:Cell Movement; D002633:Chemotaxis; D002634:Chemotaxis, Leukocyte; D008223:Lymphoma / Q000503:physiopathology; D009362:Neoplasm Metastasis; D009374:Neoplasms, Experimental / Q000503:physiopathology; D009924:Organ Culture Techniques