Synthesis and pharmacological activity of derivatives of exo-trimethylenenorbornane. III.
Two synthetic routes to (exo-5,6-trimethylenenorbornan-2-ylidene)acetonitrile starting from exo-5,6-trimethylenenorbornan-2-one are described. From the above-mentioned nitrile, 2-(exo-5,6-trimethylenenorbornan-2-ylidene)ethanamine and 2-(exo-5,6-trimethylenenorbornan-2-yl)ethanamine, as well as N,N-dimethyl and N,N-diethyl derivatives of the latter, were prepared.
D000661:Amphetamine / Q000037:antagonists & inhibitors; D000700:Analgesics / Q000138:chemical synthesis; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis; D000927:Anticonvulsants / Q000138:chemical synthesis; D001892:Camphanes / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D003292:Convulsants / Q000138:chemical synthesis; D008297:Male; D051379:Mice; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D051381:Rats; D012110:Reserpine / Q000037:antagonists & inhibitors
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D000927:Anticonvulsants; D001892:Camphanes; D003292:Convulsants; D012110:Reserpine; D000661:Amphetamine