On the inhibition of human leukocyte elastase by trifluoroacetyl tripeptides.
The recently reported Ki values for human leukocyte elastase and a series of trifluoroacetylated peptides are erroneous because the enzyme preparation was contaminated by a small amount of porcine pancreatic elastase. The correct Ki values are much higher. However, trifluoroacetylated peptides are still much more potent inhibitors than the corresponding acetylated peptides.
D000818:Animals; D005463:Fluoroacetates / Q000494:pharmacology; D006801:Humans; D007962:Leukocytes / Q000201:enzymology*; D009842:Oligopeptides / Q000494:pharmacology*; D010179:Pancreas / Q000201:enzymology; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D013552:Swine
D005463:Fluoroacetates; D009842:Oligopeptides; D010196:Pancreatic Elastase