title: Allelic expression in intergeneric fox hybrids (Alopex lagopus x Vulpes vulpes). III. Regulation of the expression of the  parental alleles at the Gpd locus linked to the X chromosome.
abstract: The electrophoretic pattern of glucose-6-phosphate dehydrogenase (G6PD) was studied in 60 intergeneric fox hybrids (Alopex lagopus x Vulpes vulpes), 33 females and 27 males. It is shown that the structural gene for G6PD, designated Gpd, is located on the X chromosome in both Arctic and silver foxes. Analysis of G6PD patterns in the erythrocytes of hybrid females demonstrated that the phenotypic expression of parental alleles at the Gpd locus varied considerably: from 1:1 to the hemizygous manifestation of an allele of either the Artic or the silver fox. The expression of the parental alleles at this locus is different in the various tissues of single female hybrids. It is suggested that the variable quantitative expression of the alleles at the Gpd locus in hybrid females is related to the presence of two cell populations having in an active state either the X chromosome of the Arctic fox or that of the silver fox. It is also proposed that the size of the two cell populations is largely affected by the different relationships between cells having different activated X-chromosomes among initiator (stem) cells from which various definitive organs and tissues develop. The number of initiator cells for erythroid tissue has been calculated to be five or six.
mesh_terms: D000483:Alleles; D000818:Animals; D005260:Female; D005589:Foxes / Q000235:genetics*; D005796:Genes; D008040:Genetic Linkage; D005954:Glucosephosphate Dehydrogenase / Q000235:genetics* / Q000378:metabolism; D006824:Hybridization, Genetic; D009030:Mosaicism; D012730:Sex Chromosomes; D014960:X Chromosome
chemical_list: D005954:Glucosephosphate Dehydrogenase