Cytotoxic agents from Bursera morelensis (Burseraceae): deoxypodophyllotoxin and a new lignan, 5'-desmethoxydeoxypodophyllotoxin.
The isolation and identification of deoxypodophyllotoxin and a new lignan, 5'-desmethoxydeoxypodophyllotoxin, from the dried exudate of Bursera morelensis (Burseraceae) are reported. Deoxypodophyllotoxin showed high activity in the KB and PS test systems; the new lignan, although highly active against the KB test system, demonstrated only marginal activity against the PS test system. A structure is suggested for the new lignan, which was named morelensin.
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D004365:Drugs, Chinese Herbal; D006801:Humans; D007942:Leukemia, Experimental / Q000188:drug therapy; D009374:Neoplasms, Experimental / Q000188:drug therapy; D010946:Plants, Medicinal / Q000032:analysis*; D011034:Podophyllotoxin / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000627:therapeutic use
D004365:Drugs, Chinese Herbal; C014451:deoxypodophyllotoxin; D011034:Podophyllotoxin