Computerized cranial tomography in Wilson disease.
Hepatolenticular degeneration (Wilson disease) is suspected by the clinical picture and confirmed by characteristic laboratory demonstration of impaired copper metabolism. Three patients with Wilson disease involving the basal ganglia were shown to have abnormalities on computerized tomography (CT) scan, whereas four other patients without signs of cerebral involvement had normal brain scans. Wilson disease may be added to the long list of diseases to which the EMI scan may make a useful diagnostic contribution.
D000328:Adult; D001479:Basal Ganglia / Q000000981:diagnostic imaging; D002570:Ceruloplasmin / Q000032:analysis; D005260:Female; D006527:Hepatolenticular Degeneration / Q000000981:diagnostic imaging* / Q000188:drug therapy; D006801:Humans; D008297:Male; D019965:Neurocognitive Disorders / Q000175:diagnosis; D010396:Penicillamine / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
D002570:Ceruloplasmin; D010396:Penicillamine