C-Alkylpiperazines. IX (1) - reversion of N1 and N4-substituents and its influence on the pharmacological activity in 2-methylpiperazine derivatives.
The synthesis of N1-(2'-pyridyl)-N4-(3,4-dimethoxyphenyl-ethyl)-2-methylpiperazine is reported. This compound was found definitely less active as an adrenolytic and vasodilator than the previously tested isomer in which the position of N1 and N4 substituents is reverted.
D000818:Animals; D002415:Cats; D055598:Chemical Phenomena; D002621:Chemistry; D051379:Mice; D010879:Piperazines / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013565:Sympatholytics; D014665:Vasodilator Agents
D010879:Piperazines; D013565:Sympatholytics; D014665:Vasodilator Agents