Alternative pathways for proline synthesis in mammalian cells.
Proline is synthesized in animal cells by way of two alternative pathways. Both of these pathways are functional in many cell lines. The relative contribution of a pathway to total proline synthesis may be altered by a mutational event. Differences in the developmental origin of a cell line are retained as differences in the pathways of proline synthesis.
D002460:Cell Line; D002875:Chromosomes; D005260:Female; D005971:Glutamates / Q000378:metabolism*; D007621:Karyotyping; D009952:Ornithine / Q000378:metabolism*; D009953:Ornithine-Oxo-Acid Transaminase / Q000378:metabolism; D010053:Ovary / Q000378:metabolism; D011392:Proline / Q000096:biosynthesis*
D005971:Glutamates; D011392:Proline; D009952:Ornithine; D009953:Ornithine-Oxo-Acid Transaminase