[Cimetidine and hyperprolactinemia].
Plasma TSH was determined in 12 normal subjects before and after administration of mg 400 of cimetidine i.v., an H2-receptor antagonist. TSH concentration remained unchanged. In 7 normal subjects, pretreated with bromocriptine; variation of plasma prolactin were studied before and after administration of mg 400 and 800 of cimetidine. Bromocriptine inhibited the increase of prolactin secretion, induced by cimetidine. It can be assumed that: a) cimetidine doesn't release hypothalamic TRH in portal vessels; b) that drug has no direct effect on pituitary cells; c) hypothalamic H2-receptor blockade by cimetidine decreases dopamine release from hypothalamus to pituitary gland.
D000328:Adult; D001971:Bromocriptine / Q000494:pharmacology*; D002927:Cimetidine / Q000494:pharmacology*; D005260:Female; D006146:Guanidines / Q000494:pharmacology*; D006801:Humans; D011388:Prolactin / Q000097:blood*; D013972:Thyrotropin / Q000097:blood
D006146:Guanidines; D001971:Bromocriptine; D002927:Cimetidine; D011388:Prolactin; D013972:Thyrotropin
Cimetidine and hyperprolactinaemia.