title: Structural features and quantitative age-dependent changes in the intervascular barrier of the guinea-pig haemochorial placenta.
abstract: The haemomonochorial placenta of the guinea-pig undergoes several quantitative changes between the 49th and 64th days of gestation, all of which are in such a direction as to increase the efficiency of transplacental transport. The fetal vessels become larger, the maternal vessels increase in surface area by proliferation of microvilli, and the effective mean distance between the two vessel sets decreases. The magnitude of these changes suggests that the efficiency of transport of hydrophilic solutes across the maternal-fetal interface could double, although changes in the number of permeation sites per unit area may modify this relationship. The presence of open intercellular spaces and fenestrations in the fetal endothelium suggests that this layer may not be a major permeability barrier in the guinea-pig, but may create an unstirred layer of extracellular fluid between endothelium and syncytiotrophoblast.
mesh_terms: D000818:Animals; D004727:Endothelium / Q000648:ultrastructure; D005110:Extracellular Space / Q000648:ultrastructure; D005260:Female; D005865:Gestational Age; D006168:Guinea Pigs; D008431:Maternal-Fetal Exchange; D010920:Placenta / Q000098:blood supply*; D011247:Pregnancy; D014327:Trophoblasts / Q000648:ultrastructure