[On glutamate dehydrogenase interaction with sex hormones].
The effect of sex hormones on the activity of glutamate dehydrogenase from beef liver was studied in vitro. The inhibitory effect of the hormones was relieved both when the guanidine groups of the enzyme were blocked and when L-arginine was added to the reaction mixture. The data obtained suggest that the guanidine groups of the arginine residues of the enzyme are involved in the realization of the inhibitory effect of the hormones.
D000818:Animals; D001120:Arginine / Q000378:metabolism / Q000494:pharmacology; D002417:Cattle; D055598:Chemical Phenomena; D002621:Chemistry; D004054:Diethylstilbestrol / Q000494:pharmacology; D004958:Estradiol / Q000494:pharmacology; D005969:Glutamate Dehydrogenase / Q000037:antagonists & inhibitors*; D012739:Gonadal Steroid Hormones / Q000494:pharmacology*; D006146:Guanidines / Q000378:metabolism; D006589:Hexestrol / Q000494:pharmacology; D008099:Liver / Q000201:enzymology; D011374:Progesterone / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013739:Testosterone / Q000494:pharmacology
D012739:Gonadal Steroid Hormones; D006146:Guanidines; D006589:Hexestrol; D013739:Testosterone; D011374:Progesterone; D004958:Estradiol; D004054:Diethylstilbestrol; D001120:Arginine; D005969:Glutamate Dehydrogenase
O vzaimodeĭstvii glutamatdegidrogenazy s polovymi gormonami