[The effect of non-steroid antiphlogistic drugs on the number of antibody-forming cells during the primary immune response].
In mice immunized with sheep erythrocytes introduction of acetylsalycilic acid (250 mg/kg), sodium salicylate (100 mg/kg) and mephenamic acid (100 mg/kg) exerted an inhibitory effect on the synthesis of antibody-forming cells and the titre of hemagglutinines in immunized animals. The acetylsalicylic acid and sodium salicylate are more effective on the 3--5th post-immunization day; the maximal effect of the mephenamic acid becomes apparent on the 7th day and its action is more lasting.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000917:Antibody Formation / Q000187:drug effects*; D000921:Antibody-Producing Cells / Q000187:drug effects*; D001241:Aspirin / Q000494:pharmacology; D006386:Hemagglutination Tests; D008528:Mefenamic Acid / Q000494:pharmacology; D051379:Mice; D012980:Sodium Salicylate / Q000494:pharmacology
D000893:Anti-Inflammatory Agents; D008528:Mefenamic Acid; D001241:Aspirin; D012980:Sodium Salicylate
Bliianie nesterondnykh protivovospalitel'nykh preparatov na kolichestvo antiteloobrazuiushchikh kletok pri pervichnom immunnom otvete.