Ocular penetration of orally administered minocycline.
Minocycline administered orally with a loading dose of 200 mg followed by 2 doses of 100 mg 12 hours apart was found to produce adequate levels in the aqueous of patients with noninflamed eyes at the time of routine cataract extraction. The plasma to aqueous ratio was approximately 2:1. This study suggests the potential usefulness of minocycline in ocular infections that are due to sensitive bacteria.
D000284:Administration, Oral; D001082:Aqueous Humor / Q000032:analysis*; D002387:Cataract Extraction; D006801:Humans; D008911:Minocycline / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D013754:Tetracyclines / Q000378:metabolism*
D013754:Tetracyclines; D008911:Minocycline