[Effect of lithium chloride on ethanol uptake by rats].
A selective uptake of ethanol by presenting its 5% solution as the only source of fluid was elaborated in rats for 2 months. It was found that lithium chloride injected intravenously in a dose of 35 mg/kg twice per 24 hours for 14 days depressed the ethanol preference causing a motivation inversion whose mechanism was associated with the changes in the activity of the hypothalamic centres of the neuroendocrine regulation. A possibility of lithium salts in the therapy of chronic alcoholism is discussed.
D000437:Alcoholism / Q000188:drug therapy* / Q000378:metabolism; D000818:Animals; D002908:Chronic Disease; D006801:Humans; D008094:Lithium / Q000627:therapeutic use*; D008297:Male; D010286:Paraventricular Hypothalamic Nucleus / Q000378:metabolism; D010909:Pituitary Hormones, Posterior; D051381:Rats; D013495:Supraoptic Nucleus / Q000378:metabolism
D010909:Pituitary Hormones, Posterior; D008094:Lithium
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