title: Collaborative study of gas-liquid chromatographic determination of methaqualone in pharmaceutical and clandestine preparations.
abstract: Eight laboratories collaboratively studied a procedure for the quantitative determination of methaqualone. HC1 in pharmaceutical and clandestine preparations. Methaqualone is extracted from an aqueous bicarbonate solution into chloroform and quantitated by gas-liquid chromatography on a 3% OV-1 column. Tetraphenylethylene is used as an internal standard. Two commerical preparations and 4 sample mixtures prepared by the author were studied. Recoveries for the 4 prepared samples ranged from 100.0 to 102.6%, and the coefficients of variation ranged from 1.58 to 4.15% for the 6 samples studied. The method has been adopted as official first action.
mesh_terms: D002849:Chromatography, Gas; D004304:Dosage Forms / Q000032:analysis; D005069:Evaluation Studies as Topic; D006801:Humans; D013287:Illicit Drugs / Q000032:analysis*; D008702:Methaqualone / Q000032:analysis*; D008722:Methods; D004364:Pharmaceutical Preparations / Q000032:analysis*; D019966:Substance-Related Disorders
chemical_list: D004304:Dosage Forms; D013287:Illicit Drugs; D004364:Pharmaceutical Preparations; D008702:Methaqualone