Laser photolysis and fluorescence studies on pyrene-thiazide and pyrene-diazoxide systems.
The laser photolysis studies on pyrene, pyrene-thiazides and pyrene-diazoxide systems in acetonitrile revealed that thiazides and diazoxide can scavenge the photoejected electron. It was found that the pyrene fluorescence is quenched by the present diuretics and related compounds and both static and dynamic quenching constants were obtained. Thiazides quench the fluorescence through both static and dynamic mechanism, while the small static quenching constant and no lifetime shortening of pyrene were observed in the case of diazoxide quencher. This difference may correspond to the difference of their diuretic activity.
D003981:Diazoxide; D004232:Diuretics; D005453:Fluorescence; D006852:Hydrochlorothiazide; D007834:Lasers; D010782:Photolysis; D011721:Pyrenes; D049993:Sodium Chloride Symporter Inhibitors; D013329:Structure-Activity Relationship
D004232:Diuretics; D011721:Pyrenes; D049993:Sodium Chloride Symporter Inhibitors; D006852:Hydrochlorothiazide; D003981:Diazoxide