Effect of ethanol on dopamine synthesis in rat striatal synaptosomes.
We have examined the effects of acute and chronic ethanol treatment and of ethanol withdrawal on dopamine synthesis in rat striatal synaptosomes in vitro. Our studies showed that acute exposure to ethanol produces a dose-related decrease in dopamine synthesis in synaptosomes. This effect of acute ethanol treatment is time-dependent, since there is an initial stimulation of dopamine synthesis, which then is followed by a depression of synthesis. Chronic exposure to ethanol in the form of a liquid diet for 2 weeks does not alter dopamine synthesis in striatal synaptosomes. After withdrawal from ethanol, dopamine synthesis in striatal synaptosomes is decreased.
D000437:Alcoholism / Q000378:metabolism; D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D004298:Dopamine / Q000096:biosynthesis*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000494:pharmacology*; D006801:Humans; D008297:Male; D051381:Rats; D013375:Substance Withdrawal Syndrome / Q000378:metabolism; D013574:Synaptosomes / Q000378:metabolism*; D014443:Tyrosine / Q000378:metabolism
D000431:Ethanol; D014443:Tyrosine; D004298:Dopamine