Fc gamma receptors receptors on fetal rat brain cells during neoplastic transformation in culture after exposure to ethylnitrosourea in vivo.
Fetal rat brain cells, undergoing neoplastic transformation in long-term culture after a single transplacental pulse of N-ethyl-N-nitrosourea on the 18th day of gestation, were investigated for Fc gamma receptors. Rosette assay with cells in suspension and the hemadsorption to cells on coverglasses were used for their detection. The receptors were found on cells after about 2 months in culture. A maximum of 20% of the cells were Fc gamma receptor-positive after 3 months. About 3 weeks later no Fc gamma receptors could be detected. Malignant rat neurogenic cell lines were also negative.
D000818:Animals; D001932:Brain Neoplasms / Q000139:chemically induced / Q000473:pathology*; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D005038:Ethylnitrosourea; D005260:Female; D005333:Fetus / Q000032:analysis; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology; D009607:Nitrosourea Compounds; D011247:Pregnancy; D051381:Rats; D011961:Receptors, Fc / Q000032:analysis*
D009607:Nitrosourea Compounds; D011961:Receptors, Fc; D005038:Ethylnitrosourea