Maternally determined susceptibility to D-amphetamine-induced stereotypy in rats.
During the first week after parturition, rat pups were removed and returned to a mother-present nest, were removed and returned to a mother-absent nest, were separated from their mothers by removal of the mothers, or were undisturbed. In adulthood when repeatedly injected with a dose of D-amphetamine which induces progressively higher levels of stereotypy (2.5 mg/kg), only subjects which had been removed and returned to a mother-present nest in infancy showed a retarded rate of increase in stereotypy.
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001519:Behavior / Q000187:drug effects*; D003913:Dextroamphetamine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006234:Handling, Psychological; D006801:Humans; D008297:Male; D008425:Maternal Behavior; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects* / Q000502:physiology
D003913:Dextroamphetamine