[A new acute-phase protein. II. Quantitative determination in the serum of patients with rheumatoid arthritis].
An antigen (SF1 or TSGA) originally found in the inflammable synovial fluid of man, which comes from the cytoplasm of neutrophils, possesses the properties of an acute-phase-protein. The production of a specific antiserum against this antigen and the method of its quantitative determination by means of the Mancini-technique are described. In 89 sera of patients with rheumatoid arthritis the antigen was determined. First results of this investigation which speak for a dependence of the antigen concentration in the serum on activity and progression of the disease are reported.
D000818:Animals; D000941:Antigens / Q000032:analysis*; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D002462:Cell Membrane / Q000276:immunology; D006801:Humans; D007106:Immune Sera; D009504:Neutrophils / Q000276:immunology; D011817:Rabbits / Q000276:immunology; D013583:Synovial Membrane / Q000276:immunology*
D000941:Antigens; D007106:Immune Sera
Untersuchungen über ein neues akute-Phase-Protein. II. Quantitative Bestimmung im Serum von Patienten mit Rheumatoid-Arthritis.