The concentrations of the prostaglandins E and F, 13 14-dihydro-15-oxo-prostaglandin F and thromboxane B2. In tissues obtained from women with and without pre-eclampsia.
The concentrations of prostaglandins E (PGE) and F (PGF), 13, 14-dihydro-15-oxo-prostaglandin F (PGFM) and thromboxane B2 (TXB2) were measured by specific radioimmunoassays in tissues obtained from women with and without pre-eclampsia. The concentrations of PGE in the amnion, chorion, decidua and placenta obtained from subjects with pre-eclampsia were significantly lower than those from subjects without pre-eclampsia. The concentration of PGE in these tissues increased significantly with gestational age and correlated with urinary oestrogen excretion. PGF concentrations were lower in the amnion and placenta of the pre-eclamptics compared to those without pre-eclampsia. The concentrations of PGFM in the amnion, decidua, and myometrium were lower in the pre-eclamptics. No significant difference in the TXB2 concentrations between the two groups of subjects were found. It is suggested that the altered tissue concentrations of prostaglandins in pre-eclamptics are due to the effects of gestational age and oestrogens and may or may not be involved in the pathogenesis of pre-eclampsia.
D000293:Adolescent; D000328:Adult; D000650:Amnion / Q000378:metabolism; D002823:Chorion / Q000378:metabolism; D003656:Decidua / Q000378:metabolism; D015237:Dinoprost / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D009215:Myometrium / Q000378:metabolism; D010920:Placenta / Q000378:metabolism; D011225:Pre-Eclampsia / Q000378:metabolism*; D011247:Pregnancy; D011458:Prostaglandins E / Q000032:analysis*; D011460:Prostaglandins F / Q000032:analysis*; D013929:Thromboxane B2 / Q000032:analysis*; D013931:Thromboxanes / Q000032:analysis*
D011458:Prostaglandins E; D011460:Prostaglandins F; D013931:Thromboxanes; C008228:15-keto-13,14-dihydroprostaglandin F2alpha; D013929:Thromboxane B2; D015237:Dinoprost