[Reaction of local myocardial blood flow in non-anesthetized dogs and anesthetized cats to the oral and parenteral administration of a Crateagus fraction (oligomere procyanidines)].
Local blood flow in the myocardium of the left ventricle in unanesthetized dogs was measured by chronically implanted heat-conduction probes. Oral administration of a fraction of Crataegus (oligomere procyanidines) led to a significant rise in blood flow for several hours depending on the dose, the highest increase reaching an average value of about + 70% of the resting flow. In dogs regularly fed with this substance for a longer period of time, a rising tendency of the matutinal resting values of myocardial blood flow towards a maximum was seen. Intravenous application of oligomere procyanidines in anesthetized cats led to a dose-dependent increase in myocardial blood flow for several minutes and a slight decrease in arterial blood pressure.
D000284:Administration, Oral; D000758:Anesthesia; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D003326:Coronary Circulation / Q000187:drug effects*; D004285:Dogs; D007263:Infusions, Parenteral; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D010946:Plants, Medicinal; D013997:Time Factors
D010936:Plant Extracts
Reaktion der Iokalen Myokarddurchblutung von wachen Hunden und narkotisierten Katzen auf orale und parenterale Applikation einer Crataegusfraktion (oligomere Procyanidine).