[Effect of alcoholic intoxication on the activity of several dehydrogenases and aminotransferases in rat brain tissue].
An acute intraperitoneal administration of ethanol (4-8 g/kg) produced a fall in the activity of malate-dehydrogenase (MDG), alanine- and aspartate-aminotransferase in homogenates and mitochondria of the cerebellum, large hemispheres and liver of the rats by 25 and 50 per cent, respectively. The activity of succinate-dehydrogenase (SDG) increased by 24 per cent in the large hemispheres and fell by 20 per cent in the liver and in the cerebellum homogenate. The activity of lactate-dehydrogenase (LDG) of the large hemispheres and liver mitochondria decreased by 30 per cent. A chronic (1 1/2-2 month long) ethanol intoxication produced a drop of the LDG and MDG in the mitochondria of the nerve structures and of aminotransferase in the liver. The SDG activity rose in the homogenate of the cerebellum, large hemispheres and of the liver by 80, 50 and 20 percent, respectively. The dehydrogenases and aminotransferases activity in the liver and nerve structures of rats in the state of abstinence was somewhat below the normal, but higher than in animals chronically consuming alcohol.
D000410:Alanine Transaminase / Q000378:metabolism; D000435:Alcoholic Intoxication / Q000201:enzymology*; D000437:Alcoholism / Q000201:enzymology*; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D001921:Brain / Q000201:enzymology*; D002531:Cerebellum / Q000201:enzymology / Q000648:ultrastructure; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008099:Liver / Q000201:enzymology; D008291:Malate Dehydrogenase / Q000378:metabolism; D008297:Male; D008928:Mitochondria / Q000201:enzymology; D008930:Mitochondria, Liver / Q000201:enzymology; D009043:Motor Activity; D010088:Oxidoreductases / Q000378:metabolism*; D051381:Rats; D013385:Succinate Dehydrogenase / Q000378:metabolism; D013687:Telencephalon / Q000201:enzymology / Q000648:ultrastructure; D000637:Transaminases / Q000378:metabolism*
D010088:Oxidoreductases; D007770:L-Lactate Dehydrogenase; D008291:Malate Dehydrogenase; D013385:Succinate Dehydrogenase; D000637:Transaminases; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
Vliianie alkogol'noĭ intoksikatsii na aktivnost' nekotorykh degidrogenaz i aminotransferaz v tkani golovnogo mozga krys.