Biological activity of high dose of des-asp 1-, ileu 8-angiotensin II in man.
The biological activity of high doses of des-asp 1-, ileu 8-angiotensin II (AIIIA) was studied in man. In 5 normal men an intravenous infusion of 600 ng/kg/min of AIIIA for 30 min caused a slight rise in blood pressure, a decrease in plasma renin activity and an increase in plasma aldosterone. This dose inhibited pressor and steroidogenic actions of angiotensin II infused into the same 5 normal men at a rate of 20 ng/kg/min for 30 min. These results are considerably different from our previous report using lower dose (200 ng/kg/min) of AIIIA and indicate that in man AIIIA has both agonist and antagonist activities on the peripheral arterioles as well as on the adrenal cortex.
D000450:Aldosterone / Q000097:blood*; D000804:Angiotensin II / Q000008:administration & dosage / Q000037:antagonists & inhibitors*; D001794:Blood Pressure / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D012083:Renin / Q000097:blood*
D000804:Angiotensin II; D000450:Aldosterone; D012083:Renin; D006854:Hydrocortisone