title: Gonadotrophin suppression by steroids in normal, adult male rats.
abstract: Effect of subcutaneous administration of various doses of different steroids on serum levels of LH and FSH in normal, adult male rats were investigated. Each steroid was injected daily during 7 days in doses of 50, 25, 12.5 or 6.25 mug per 100 g body weight. Ring A 5alpha-reduced testosterone metabolites exerted high activity in the suppressing serum LH and FSH levels. 5alpha-Androstane-3beta, 17 beta-diol had in the doses tested, however, no such effects on serum gonadotrophins, Serum LH concentrations in normal rats appeared more sensitive to steroid treatment than serum FSH concentrations.
mesh_terms: D000734:Androstenediols / Q000494:pharmacology; D000735:Androstenedione / Q000494:pharmacology; D000818:Animals; D013196:Dihydrotestosterone / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000494:pharmacology; D005640:Follicle Stimulating Hormone / Q000097:blood*; D012739:Gonadal Steroid Hormones / Q000494:pharmacology*; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D011374:Progesterone / Q000494:pharmacology; D051381:Rats; D013739:Testosterone / Q000097:blood
chemical_list: D000734:Androstenediols; D012739:Gonadal Steroid Hormones; D013196:Dihydrotestosterone; D013739:Testosterone; D000735:Androstenedione; D011374:Progesterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone