title: [Pharmacological studies on the antiphlogistic effect of pentosanpolysulfate in combination with metamizol].
abstract: In the present study we investigated the antiinflammatory effect of pentosanpolysulfate (SP 54) in combination with metamizol using different forms of rat paw edema (induced by dextrane, hyaluronidase, trypsin, formaldehyde, carragenine or kaolin). After s. c. application Probaphen, a new drug containing pentosanpolysulfate, metamizol, and lidocaine, proved in our experiments to exert an antiphlogistic effect about 40% stronger than the equivalent amount of SP 54 alone. Since pentosanpolysulfate by itself has no analgetic activity, its combination with metamizol results in a formulation which is not only a more potent antiinflammatory drug but will aslo counteract pains which accompany most edematous reactions. Probaphen may therefore be suggested for the treatment of rheumatoid arthritis and similar inflammatory and edematous processes. First clinical studies and reports on Probaphen fully support our pharmacological results.
mesh_terms: D000632:Aminopyrine / Q000031:analogs & derivatives*; D000818:Animals; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D004177:Dipyrone / Q000627:therapeutic use*; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D004487:Edema / Q000188:drug therapy*; D007249:Inflammation / Q000188:drug therapy*; D008012:Lidocaine / Q000627:therapeutic use; D008297:Male; D010146:Pain / Q000188:drug therapy; D010426:Pentosan Sulfuric Polyester / Q000627:therapeutic use*; D011134:Polysaccharides / Q000627:therapeutic use*; D051381:Rats
chemical_list: D004338:Drug Combinations; D011134:Polysaccharides; D000632:Aminopyrine; D010426:Pentosan Sulfuric Polyester; D004177:Dipyrone; D008012:Lidocaine
vernacular_title: Pharmakologische Studien zur antiphlogistischen Wirkung von Pentosanpolysulfat in Kombination mit Metamizol