[Electromyographic studies on the effect of the cinnamamide derivative LCB-29 in spastic syndromes (author's transl)].
In ten patients with para- or tetraspastic syndromes of various etiology 5 different spastic phenomena demonstrating pathologically raised excitability of muscle regulation functions were registered electromyographically before and 1 h after i.v. administration of N-(hydroxy-2-ethyl)-cinnamamide (LCB-29). In the majority of cases a marked decrease of spasticity was registered. The rapid onset of this effect of LCB-29 allowed constant test conditions and therefore eliminated other influences on spasticity. The decrease of raised polysynaptic excitability at spinal level led, at least in part, to the assumption of a spinal site of action of LCB-29. The absence of a sedative effect with oral medication makes a strong central effect seem less probable.
D000328:Adult; D000368:Aged; D002934:Cinnamates / Q000627:therapeutic use*; D004341:Drug Evaluation; D004576:Electromyography; D004679:Encephalomyelitis / Q000150:complications; D006801:Humans; D008875:Middle Aged; D009128:Muscle Spasticity / Q000188:drug therapy* / Q000209:etiology; D011782:Quadriplegia / Q000150:complications
D002934:Cinnamates
Elektromyographische Untersuchungen zur Wirkung des Zimtsäurederivats LCB-29 bei spastischen Syndromen.