title: Short- and long-term effects of a massive dose of 6-OH-DA upon marsh mice.
abstract: Single, sublethal subcutaneous doses of 6-hydroxydopamine (6-OH-DA) were given to young adult male and female Marsh mice. The ability of 6/8 males to sire 15 or more days later was not abolished. Of 10 females dosed during pregnancy, 6 failed to deliver and lost substantially in body weight. Of the 4 that delivered, 2 cannabalized their young. The offspring of the 6-OH-DA-dosed fathers and mothers showed no gross anatomical defects nor lessened survival rates. Confrontation of 6-OH-DA-dosed males with control males as pairs demonstrated increased anal sniffing as compared with control-pair confrontation. In a long-term series with males, liver anomalies including tumor development were demonstrated for 6-OH-DA. Lymphoid tumor induction was not affected. However, 3 local fibrosarcomas and 1 intrasorbital giant cell sarcoma arose. A sublethal dose of L-dopa had no lasting effect on male mouse aggression nor on other behavioral manifestations that would implicate 6-OH-DA formation as a metabolic route.
mesh_terms: D000374:Aggression / Q000187:drug effects; D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002190:Cannibalism; D005260:Female; D006801:Humans; D006892:Hydroxydopamines / Q000008:administration & dosage / Q000494:pharmacology*; D007980:Levodopa / Q000494:pharmacology; D008297:Male; D008431:Maternal-Fetal Exchange; D051379:Mice; D009369:Neoplasms / Q000139:chemically induced; D011247:Pregnancy; D013997:Time Factors
chemical_list: D006892:Hydroxydopamines; D007980:Levodopa