[Diuresis and natriuresis following application of bemeticide and triamterence in rats on normal and low-potassium diet (author's transl)].
The investigations were carried out under identical conditions and were aimed at determining the effects of different doses of the two diuretics: 3-(alpha-methylbenzyl)-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxide (bemeticide) and 2,4,7-triamino-6-phenylpteredine (triamterene) as well as for their joint administration at ratios of 1:2 and 1:4, resp., with regard to renal elimination of sodium and potassium as well as to urinary output in normally and low-potassium-fed rats. The 1:2 combination of bemeticide and triamterene resulted in an optimum diuretic and sodium elimination effect with potassium values within normal range, both in the normally and in the low-potassium-fed animals. An increase of the triamterene component from the 1:2 to the 1:4 ratio did not yield additional advantages.
D000818:Animals; D001581:Benzothiadiazines; D004032:Diet; D004231:Diuresis / Q000187:drug effects*; D004232:Diuretics; D004305:Dose-Response Relationship, Drug; D007008:Hypokalemia / Q000652:urine; D007671:Kidney Concentrating Ability / Q000187:drug effects; D008297:Male; D009318:Natriuresis / Q000187:drug effects*; D011188:Potassium / Q000008:administration & dosage* / Q000652:urine; D051381:Rats; D049993:Sodium Chloride Symporter Inhibitors / Q000494:pharmacology*; D014223:Triamterene / Q000008:administration & dosage / Q000494:pharmacology*
D001581:Benzothiadiazines; D004232:Diuretics; D049993:Sodium Chloride Symporter Inhibitors; D011188:Potassium; D014223:Triamterene
Diurese und Salurese der Ratte nach Applikation von Bemetizid und Triamteren bei normaler und kaliumarmer Fütterung