title: Distribution of the myocardial tissue PO2 in the rat and the inhomogeneity of the coronary bed.
abstract: The structural inhomogeneity of the myocardial capillary bed is stimulated by microcirculatory units (MCU's) in a diffusion model. This stimulation is based on MCU's in which the arrangement of the capillary ends (concurrent structure, partial and total countercurrent (structure, helical structure) as well as the structure and supply parameters are varied. The variation of these parameters is based on own measurements of the intracapillary HbO2 saturation as well as on the following parameters from the literature: frequency distribution of capillary distance and capillary radius, mean capillary length or capillary section length respectively, arterial and mean venous PO2, mean coronary blood flow, mean O2 consumption and diffusion conductivity. The analysis of O2 supply of the normoxic rat heart shows that an O2 diffusion shunt is obligatory except of MCU's with an extremely large capillary distance or with a concurrent capillary structure. Therefore the minimal tissue PO2 lies at the level of the capillary venous PO2 of a MCU. The maximum of the total PO2 frequency distribution in the normoxic rat myocardium lies at 25 +/- 5 mm Hg, i.e. above the mean venous PO2 (20 mm Hg). Tissue PO2 values between 0 and 5 mm Hg amount to 0.5% i.e. they are extremely rare. Tissue PO2 values of 0-1 mm Hg represent less than 0.2%.
mesh_terms: D000818:Animals; D002196:Capillaries / Q000033:anatomy & histology; D003326:Coronary Circulation; D003331:Coronary Vessels / Q000033:anatomy & histology*; D004058:Diffusion; D008433:Mathematics; D008722:Methods; D008954:Models, Biological; D009206:Myocardium / Q000032:analysis*; D010100:Oxygen / Q000032:analysis* / Q000097:blood; D051381:Rats
chemical_list: D010100:Oxygen