[Sensitivity of fragmented and stratified sea urchin embryos to cytotoxic neuropharmacological preparations].
The red half embryos and related quarter embryos (yolk and pigment) of Arbacia lixula, obtained by means of centrifugation of the eggs in sucrose gradient, retain the normal level of sensitivity and supersensitivity to cytotoxic neuropharmaca, antagonists of biogenic monoamines. The white half embryos and clear quarter embryos practically lack supersensitivity whereas the granular quarter embryos restore it to the initial level. The non-pigmented blastomers of stratified embryos are characterized by somewhat weakened supersensitivity. A suggestion is put forward that the supersensitive embryos of A. lixula possess a sensibilizing factor which couples the supersensitivity receptors with the processes of cell division and moves together with the yolk granules upon centrifugation. This factor is not observed in the Strongylocentrotus granularis embryos lacking evident supersensitivity.
D000662:Amphetamines / Q000494:pharmacology; D000818:Animals; D001561:Benzilates / Q000494:pharmacology; D001679:Biogenic Amines / Q000037:antagonists & inhibitors*; D003078:Colchicine / Q000494:pharmacology; D004048:Diethylamines / Q000494:pharmacology; D005260:Female; D007211:Indoles / Q000494:pharmacology; D010063:Ovum / Q000187:drug effects; D010640:Phenothiazines / Q000494:pharmacology; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology; D011955:Receptors, Drug / Q000187:drug effects; D012617:Sea Urchins / Q000187:drug effects / Q000196:embryology*; D014363:Tryptamines / Q000494:pharmacology
D000662:Amphetamines; D001561:Benzilates; D001679:Biogenic Amines; D004048:Diethylamines; D007211:Indoles; D010640:Phenothiazines; D000644:Quaternary Ammonium Compounds; D011955:Receptors, Drug; D014363:Tryptamines; D003078:Colchicine
Chuvstvitel'nost' zarodysheĭ-fragmentov i stratifitsirovannykh zarodysheĭ moskikh ezheĭ k tsitotoksicheskim neĭrofarmakologicheskim preparatam.