Plant anticancer agents VI: Isolation of voacangine, voacamine, and epivoacorine from Tabernaemontana arborea sap.
Fractionation of the sap of Tabernaemontana arborea, guided by cytotoxicity against the P-388 lymphocytic leukemia, yielded the known indole alkaloids voacangine, voacamine, and epivoacorine as the major cytotoxic constituents.
D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D002855:Chromatography, Thin Layer; D007211:Indoles / Q000302:isolation & purification / Q000494:pharmacology; D007942:Leukemia, Experimental / Q000473:pathology
D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D007211:Indoles