[Influence of the beta-receptor blocker nifenalol on insulin secretion in normal subjects and diabetic patients (author's transl)].
In 10 insulin-independent diabetic patients and 5 healthy volunteers the basal and glucose-stimulated insulin secretion was tested before and during oral treatment with the beta-blocker 1-(4-nitrophenyl)-2-isopropylaminoethanol (nifenalol, Inpea). In diabetic patients the insulin secretion was not changed by Inpea. The fasting blood sugar levels were slightly elevated in 8 of these patients. This result, which could not be ascertained statistically, may be due to a slight intrinsic activity of this beta-blocker. The normal subjects showed different responses. In one person the glucose tolerance deteriorated by Inpea.
D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D003920:Diabetes Mellitus / Q000097:blood / Q000378:metabolism*; D004983:Ethanolamines / Q000494:pharmacology*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D001786:Blood Glucose; D004983:Ethanolamines; D007328:Insulin
Einfluss des beta-Rezetptorenblockers Nifenalol auf die Insulinsekretion bei Normalpersonen und Diabetikern