title: Perturbation of respiration in Candida utilis: induction of metabolic oscillations.
abstract: The effects of potentially perturbating influences on the respiration of glucose-grown Candida utilis were studied using an open oxygen electrode system. Periods of anaerobiosis as short as 2 min produced an oscillation in respiration after the air supply was restored. Longer exposure to anoxia was followed by an overshoot in dissolved oxygen after switching back to a gas phase of air. Centrifugation, cold shock or nutrient starvation caused less disturbance to respiration rates than did anaerobiosis. The high frequency oscillations (period about 5 min) resulting from anaerobic-aerobic transitions are contrasted with the slow cell cycle-dependent oscillations previously observed in synchronous cultures.
mesh_terms: D000693:Anaerobiosis; D002175:Candida / Q000187:drug effects / Q000378:metabolism*; D002258:Carbonyl Cyanide m-Chlorophenyl Hydrazone / Q000494:pharmacology; D003080:Cold Temperature; D005947:Glucose / Q000378:metabolism; D010100:Oxygen / Q000494:pharmacology; D010101:Oxygen Consumption / Q000187:drug effects
chemical_list: D002258:Carbonyl Cyanide m-Chlorophenyl Hydrazone; D005947:Glucose; D010100:Oxygen