title: [Cefamandole: in vitro and in vivo activity].
abstract: Among the cephalosporin antibiotics, a relatively new derivative of Cefamandole has been studied, the sodium salt of its formyl ester, Cefamandole nafate. It has shown a broad spectrum of antibiotic activity against a wide variety of Gram-positive and Gram-negative Bacteria (127 strains); the susceptibility was good even with beta-lactamase-producing bacteria. Good protective doses (PD50) were found after mice infections with Staphylococcus aureus and Salmonella wien. The pharmacokinetics of Cefamandole carried out comparatively in 5 human volunteers and in laboratory animals exhibited high levels, especially in the urines.
mesh_terms: D000818:Animals; D002435:Cefamandole / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D002511:Cephalosporins / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D006168:Guinea Pigs; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D008826:Microbial Sensitivity Tests; D051381:Rats; D011919:Rats, Inbred Strains; D012481:Salmonella Infections, Animal / Q000188:drug therapy; D013203:Staphylococcal Infections / Q000188:drug therapy; D013997:Time Factors
chemical_list: D002511:Cephalosporins; D002435:Cefamandole
vernacular_title: Cefamandolo: attivita' in vitro ed in vivo.