[Hypothalamic self-stimulation during the abstinence syndrome in morphine-dependent rats].
Rats with lateral hypothalamic self-stimulation were treated chronically with morphine (30 injections in the course of 15 days) in doses increasing stepwise  from 20 to 120 mg/kg per injection. Morphine facilitated self-stimulation from the 9th injection. Both short-term abstinence (16-18 hours) and cessation of the narcotic resulted in inhibition of the response. Full suppression of self-stimulation occurred under the administration of nalorphine, morphine antagonist, in a dose of 5 mg/kg.
D000818:Animals; D003864:Depression, Chemical; D004558:Electric Stimulation; D006801:Humans; D007031:Hypothalamus / Q000503:physiopathology*; D008297:Male; D009020:Morphine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D009269:Nalorphine / Q000494:pharmacology; D051381:Rats; D013268:Stimulation, Chemical; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology*; D019966:Substance-Related Disorders
D009020:Morphine; D009269:Nalorphine
Gipotalamicheskaia samostimuliatsiia pri abstinentnom sindrome u morfinzavisimykh krys.