Prilocaine effect on aconitine-induced arrhythmias.
Prilocaine, a synthetic tertiary amine with local anesthetic properties, suppressed aconitine-induced atrial and ventricular arrhythmias in the cat. In normal animals, prilocaine decreased the heart rate. In the group of successfully treated arrhythmic cats as well as in normal animals, the drug increased the blood pressure, while the equally effective antiarrhythmic drug, lidocaine, did decrease blood pressure.
D000157:Aconitine / Q000009:adverse effects*; D031841:Aconitum / Q000031:analogs & derivatives*; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced*; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D004562:Electrocardiography; D006339:Heart Rate / Q000187:drug effects; D008012:Lidocaine / Q000494:pharmacology; D011318:Prilocaine / Q000494:pharmacology*
D011318:Prilocaine; D008012:Lidocaine; D000157:Aconitine