title: [Drug-induced fixed exanthema: immuno-allergologic study of 37 patients].
abstract: The Authors performed ona group a patients suffering from drug exanthema a thorough clinico-anamnestic and allergo-immunological investigation (skin reactions, patch-tests, Prausnitz-Küstner passive transport, in vitro lymphocyte blastization, total serum IgE radioimmunoassay). The results obtained do not support an immunoallergical pathogenesis of this syndrome. The possible alternative hypotheses and the future perspectives of study are discussed.
mesh_terms: D000293:Adolescent; D000328:Adult; D001241:Aspirin / Q000009:adverse effects; D002511:Cephalosporins / Q000009:adverse effects; D002648:Child; D005076:Exanthema / Q000139:chemically induced* / Q000209:etiology / Q000276:immunology; D005260:Female; D006801:Humans; D007116:Immunization, Passive; D007073:Immunoglobulin E; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D012882:Skin Tests; D013752:Tetracycline / Q000009:adverse effects
chemical_list: D002511:Cephalosporins; D007073:Immunoglobulin E; D013752:Tetracycline; D001241:Aspirin
vernacular_title: L'esantema fisso da farmaci: studio immuno-allergologico di 37 pazienti.