Factor VIII inhibition associated with chlorpromazine-induced hepatic injury.
A 90-year-old man was given chlorpromazine for sedation and 2 weeks later developed cholestatic jaundice and subsequently a factor VIII inhibitor. His death 4 weeks after institution of chlorpromazine, from massive bleeding, coupled with the autopsy finding of intrahepatic cholestatic jaundice, suggests that both adverse reactions were due to the drug.
D000368:Aged; D056486:Chemical and Drug Induced Liver Injury; D002746:Chlorpromazine / Q000009:adverse effects*; D005169:Factor VIII / Q000037:antagonists & inhibitors*; D006801:Humans; D008297:Male
D005169:Factor VIII; D002746:Chlorpromazine