Biological standardization of potency testing of diphtheria-tetanus-pertussis vaccines.
Active protection tests were introduced for the potency testing of the toxoid components of the DTP vaccine. The standardization of these tests is described, with special attention on WHO requirements. A freeze-dried, adsorbed DTP vaccine was prepared for use under tropical or subtropical conditions. The potency testing of the components of this vaccine is presented in this paper.
D000818:Animals; D004168:Diphtheria Toxoid / Q000276:immunology / Q000592:standards*; D005260:Female; D006168:Guinea Pigs; D006814:Hungary; D007109:Immunity; D008297:Male; D051379:Mice; D010567:Pertussis Vaccine / Q000276:immunology / Q000592:standards*; D013745:Tetanus Toxoid / Q000276:immunology / Q000592:standards*
D004168:Diphtheria Toxoid; D010567:Pertussis Vaccine; D013745:Tetanus Toxoid