Quinidine-induced agranulocytosis.
In a 75-year-old man, agranulocytosis and septicemia developed after eight weeks of quinidine sulfate therapy. An IgG antibody requiring the presence of quinidine was shown by complement-dependent leukocytotoxicity and leukoagglutination reactions. The antibody did not cross-react with quinine and was active against WBCs obtained from normal subjects and from the patient himself.
D000368:Aged; D000380:Agranulocytosis / Q000139:chemically induced* / Q000276:immunology; D001281:Atrial Fibrillation / Q000188:drug therapy; D003601:Cytotoxicity Tests, Immunologic; D004342:Drug Hypersensitivity / Q000209:etiology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007962:Leukocytes / Q000276:immunology; D008297:Male; D011802:Quinidine / Q000009:adverse effects* / Q000276:immunology / Q000627:therapeutic use
D007074:Immunoglobulin G; D011802:Quinidine