title: Anamnestic studies in multiple sclerosis: a relationship between familial multiple sclerosis and neoplasia.
abstract: A survey of family histories of malignant neoplasia in multiple sclerosis (MS) patients indicates that a positive history of cancer in near relatives is present in 44 percent of patients and 46 percent of controls. However, those MS patients having such a positive history were much more likely than others to also have a family history of MS. Contrariwise, MS patients with a positive family history of MS had a significantly higher rate of cancer in first degree relatives (71 percent) than others. There was a trend indicating less cancer in families of MS patients possessing the HLA-B7 and DW2 histocompatibility antigens.
mesh_terms: D005260:Female; D006649:Histocompatibility Antigens / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics*
chemical_list: D006649:Histocompatibility Antigens