title: Changes in the morphology of ribosomes in uterine epithelial cells under various hormonal conditions.
abstract: The ultrastructural morphology of "free" cytoplasmic ribosomes of rat uterine epithelial cells was studied during diestrus, estrus, after ovariectomy, and after estradiol-17 beta administration to rats that were ovariectomized 1 to 25 weeks before hormone treatment. A change in size and contrast of ribosomes was observed concomitant with a transition from pre-existing monosomes to polysomes depending on the dose of estradiol and its route of application. In 3 weeks ovariectomized rats these changes in ribosomal granules take place at approximately the same time (30-45 min) when synthesis of "induced protein" was described biochemically. The morphological events after estradiol administration are discussed with respect to a primary site of estrogen action.
mesh_terms: D000818:Animals; D002369:Castration; D004031:Diestrus; D004717:Endometrium / Q000648:ultrastructure*; D004958:Estradiol; D004971:Estrus; D005260:Female; D011247:Pregnancy; D051381:Rats; D012270:Ribosomes
chemical_list: D004958:Estradiol