title: The effects of chronic disulfiram treatment on mice infected with Schistosoma mansoni.
abstract: Compounds which block the formation of the egg shell in female schistosomes are thought to have chemotherapeutic value. One of these compounds, disulfiram, when given chronically in the diet produced a 60% reduction in the mortality of mice carrying a heavy schistosome burden. This reduction in mortality was associated with an 80% decrease in granuloma formation. On the other hand, there was no decrease in the amount of periportal inflammation in drug-treated animals. While the use of this drug results in significant amelioration of schistosomal pathology, its effects are rapidly reversible, thus severely limiting its chemotherapeutic potential.
mesh_terms: D000818:Animals; D004221:Disulfiram / Q000627:therapeutic use* / Q000633:toxicity; D005260:Female; D007422:Intestines / Q000473:pathology; D008099:Liver / Q000473:pathology; D008168:Lung / Q000473:pathology; D051379:Mice; D010063:Ovum / Q000187:drug effects; D012550:Schistosoma mansoni / Q000187:drug effects; D012552:Schistosomiasis / Q000188:drug therapy* / Q000473:pathology; D013154:Spleen / Q000473:pathology
chemical_list: D004221:Disulfiram