Clinical characteristics of familial acute anterior uveitis.
Of 24 patients with familial acute anterior uveitis (AAU) 22 cases were non-granulomatous and 2 granulomatous. Of the 23 HLA tested patients 19 had the antigen HLA-B27. The 2 granulomatous and 2 non-granulomatous AAU cases were HLA-B27 negative. The iritis associated with the antigen HLA-B27 was unilateral, acute and recurrent, with cells and flare in the aqueous humor, and it lasted on an average 5 weeks. Keratic precipitates were never mutton fat, if the antigen B27 was present. X-ray examination of 8 patients revealed sacroilittis in 5. It is concluded that certain factors like trauma or infective agents may provoke familial AAU which is in close relationship with the HLA-B27 associated rheumatic group of diseases.
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D005131:Eye Injuries / Q000150:complications; D005260:Female; D006099:Granuloma / Q000235:genetics; D006680:HLA Antigens; D006801:Humans; D007239:Infections / Q000150:complications; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D012737:Sex Factors; D014606:Uveitis, Anterior / Q000175:diagnosis / Q000209:etiology / Q000235:genetics*
D006680:HLA Antigens