A pharmacokinetic study of 3H-diosmine.
A pharmacokinetic study of 3H-labelled 7-rhamnoglycoside of 5,7,3'-trihydroxy-4'-methoxyflavone (3H-diosmine) administered both i.v. and orally, shows the great ease with which it is absorbed in digestion. A very sharp difference in elimination between the two modes of treatment must be associated with a difference in metabolism. A study of fixation confirms this conclusion. In particular the fixation on the tunica vascularis, perhaps due to a metabolite, appears relatively late. Furthermore the existence of an enterohepatic cycle assures a permanent hepatic binding.
D000818:Animals; D001665:Binding Sites / Q000187:drug effects; D004145:Diosmin / Q000008:administration & dosage / Q000378:metabolism* / Q000494:pharmacology; D005260:Female; D005419:Flavonoids / Q000378:metabolism*; D007408:Intestinal Absorption / Q000187:drug effects; D007700:Kinetics; D008297:Male; D051381:Rats; D014316:Tritium
D005419:Flavonoids; D014316:Tritium; D004145:Diosmin