[Sulfalene pharmacogenetics. I. The genetic determination of the pharmacokinetic indices].
Genetic determination of pharmacokinetics of sulfalen, a new antibacterial drug, has been studied in 28 twin pairs of Moscow Russian population. In order to determine the degree of heritability of such pharmacokinetic parameters of sulfalen as t 1/2 (half-life); Vd and delta (apparent and specific volumes of distribution) and Co (apparent initial concentration) Holtsinger H-statistics values have been calculated, which are 0.891, 0.866, 0.766 and 0.797 respectively. Possible causes of discrepancies between these values and the coefficients of genetic determination G, calculated by decomposition of general phenotypical dispercion of the parameters via the main equation of quantitative traits of genetics are given (0.913, 0.762, 0.828, 0.856 in that order). The data obtained make it possible to assume that genetic determination t 1/2 of sulfalen is carried out within the system of monogenous interaction (HD = 0.91, HA = 0), that of Vd and Co--within the system of additive-polygenous interaction, while linear and non-linear effects contribute to delta determination (HD = 0.232, HA = 0.596).
D000284:Administration, Oral; D000328:Adult; D005260:Female; D006801:Humans; D007700:Kinetics; D008433:Mathematics; D009031:Moscow; D010597:Pharmacogenetics; D010641:Phenotype; D011247:Pregnancy; D013415:Sulfalene / Q000097:blood*; D013424:Sulfanilamides / Q000097:blood*; D013997:Time Factors; D014429:Twins, Dizygotic; D014430:Twins, Monozygotic
D013424:Sulfanilamides; D013415:Sulfalene
Farmakogenetika sul'falena. Soobshchenie I. Geneticheskaia determinatsiia farmakokineticheskikh pokazateleĭ.