Association of immunoblastic lymphadenopathy and Hashimoto's thyroiditis.
A 75-year-old white woman with a supraclavicular mass and primary hypothyroidism was found to have immunoblastic lymphadenopathy and Hashimoto's thyroidits. Peripheral blood contained normal percentages of T and B lymphocytes, but there was a markedly decreased response to phytohemagglutinin and to skin testing for delayed hypersensitivity. Since lack of suppressor T cells, B-cell proliferation, and decreased immunosurveillance may be causative factors in these diseases, it was of interest to document this rare association of immunoblastic lymphadenopathy and Hashimoto's thyroiditis.
D000368:Aged; D001327:Autoimmune Diseases / Q000276:immunology; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008206:Lymphatic Diseases / Q000150:complications*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology; D008218:Lymphocytosis / Q000276:immunology; D008223:Lymphoma / Q000150:complications* / Q000276:immunology / Q000473:pathology; D013964:Thyroid Neoplasms / Q000150:complications* / Q000276:immunology / Q000473:pathology; D013967:Thyroiditis, Autoimmune / Q000150:complications* / Q000276:immunology / Q000473:pathology