[Study of the toxicity and antiblastoma activity of antibiotics echinomycin and 6270 in complexes with DNA].
Studies with the use of intact inbred albino mice showed that in intravenous administration the acute toxicity of antibiotic No. 6270 and echinomycin in complexes with DNA increased 3--4 times as compared to the toxicity of the same antibiotics used without the complex. Under the experimental conditions with 3-fold intravenous administration at 72-hour intervals in doses equivalent by their acute toxicity, the antitumor activity of the echinomycin complex with DNA against the solid form of lymphosarcoma L10-1 was approximately 4 times lower than the activity of the antibiotic used alone. Like echinomycin, antibiotic No. 6270 in complex with DNA used according to the same administration scheme in doses equivalent by their acute toxicity had a lower inhibitory effect on growth of lymphosarcoma L10-1 and sarcoma 180 as compared to its use alone.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000633:toxicity; D004247:DNA / Q000008:administration & dosage* / Q000633:toxicity; D004359:Drug Therapy, Combination; D004448:Echinomycin / Q000008:administration & dosage* / Q000633:toxicity; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy*; D051379:Mice; D011810:Quinoxalines / Q000008:administration & dosage*; D012513:Sarcoma, Experimental
D000903:Antibiotics, Antineoplastic; D011810:Quinoxalines; D004448:Echinomycin; D004247:DNA
Izuchenie toksichnosti i antiblastomnoĭ aktivnosti antibiotikov ékhinomitsina i 6270 v kompleksakh s DNK.