[Experimental study of the emotiontropic effect of lithium: ambivalent dose-dependent effect in "reserpine depression" and preventive anti-stress effect].
Experiments on male-rats with a chronic administration of lithium show that it exerts a dose-dependence ambivalent action on the biochemical and behavioural characterisics of "reseprine depressions". In this way changes in the catecholeamine excretion and disturbances of conditioned reactions of advoidance are prevented (in dosages 10 mg/kg , and increasing them to 50 mg/kg). An opposite influence of different doses of lithium was also seen in a study of the hypothalamic resources of noradrenalin in the remote period of an after action of reserpine. The use of lithium exerts an expressed preventive effect in experimental emotional stress, preventing the development of suprarenal reactions and disorders of conditioned reflexes of avoidance. The authors discuss some neurochemical mechanisms of ambivalent and emotiotropic effect of lithium and the exedience of an enlargement of its prophylactic use.
D000311:Adrenal Glands / Q000378:metabolism; D000818:Animals; D003863:Depression / Q000139:chemically induced* / Q000188:drug therapy / Q000378:metabolism; D004837:Epinephrine / Q000378:metabolism; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism; D008094:Lithium / Q000494:pharmacology / Q000627:therapeutic use*; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D012110:Reserpine; D013315:Stress, Psychological / Q000187:drug effects*
D012110:Reserpine; D008094:Lithium; D009638:Norepinephrine; D004837:Epinephrine
Eksperimental'noe issledovanie ĕmotsiotropnogo deĭstviia litiia: ambivalentnoe doze-zavisimoe vliianie pri "rezerpinovoĭ depressii" i preventivnyĭ antistressornyĭ éffekt.