Effect of experimental neurosis on the secretion of acid gastric proteinases in dogs.
In experiments on dogs with gastric cannula we proved that the gastric juice, obtained after intravenous injection of insulin, contained after separation of DEAE Sephadex A-50 5--7 proteolytically active fractions. In four dogs of both sexes the ratio and number of individual fractions remained constant in control experiments. However, there were differences between the animals. After induction of experimental neurosis (by the collision of the alimentary and avoidance reflex) all animals showed the same marked changes in the chromatographic patterns of acid proteinases. There was a change not only in the ratio of two larger groups of proteolytically active fractions but also in the total number of all fractions. These changes persisted for 8--10 weeks after induction of experimental neurosis.
D000818:Animals; D002852:Chromatography, Ion Exchange; D004285:Dogs; D005260:Female; D005750:Gastric Juice / Q000201:enzymology*; D006801:Humans; D008297:Male; D009497:Neurotic Disorders / Q000201:enzymology*; D010447:Peptide Hydrolases / Q000378:metabolism
D010447:Peptide Hydrolases