Preparation and biological actions of some symmetrically N,N-disubstituted dopamines.
The title compounds have been synthesized and evaluated for emetic effects in the dog, actions on the cardioaccelerator nerve in the cat, pecking in pigeons, and for behavioral effects following both peripheral and direct intracerebral injection into the nucleus accumbens and caudate-putamen of the rat. Generally, in the series studied, the N,N-diethyl and N,N-di-n-propyl congeners of dopamine displayed notably high degrees of activity. However, the test compounds exerted differing effects on peripheral and central dopamine receptors and in the area postrema. Differentiations of the activities of the different homologues within the brain were also shown.
D000818:Animals; D001058:Apomorphine / Q000037:antagonists & inhibitors; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000187:drug effects*; D002415:Cats; D010856:Columbidae; D003342:Corpus Striatum / Q000187:drug effects; D004285:Dogs; D004298:Dopamine / Q000031:analogs & derivatives* / Q000494:pharmacology; D018492:Dopamine Antagonists; D004639:Emetics; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D009431:Neural Conduction / Q000187:drug effects; D009714:Nucleus Accumbens / Q000187:drug effects; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects; D013239:Stereotyped Behavior
D018492:Dopamine Antagonists; D004639:Emetics; D011954:Receptors, Dopamine; D001058:Apomorphine; D004298:Dopamine