title: [Antiviral agents / 9th communication: virustatically active N-(1-adamantyl)-thiourea derivatives based on cyclic secondary amines (author's transl)].
abstract: By nucleophilic addition of pyrrolidine (2a), piperidine (2b), 3-hydroxypiperidine (2c), and 4-hydroxypiperidine (2d) on 1-adamantyl-isothiocyanate (1), the N',N'-disubstituted N-(1-adamantyl)-thiourea derivatives 3a, 3b, 3c, and 3d are accessible. Particularly 3d exhibits remarkable antiviral activity vaccinia and herpes virus.
mesh_terms: D000218:Adamantane / Q000031:analogs & derivatives; D000998:Antiviral Agents; D001952:Bridged-Ring Compounds / Q000031:analogs & derivatives; D006564:Herpesviridae / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D013055:Spectrophotometry, Infrared; D013890:Thiourea / Q000031:analogs & derivatives*; D014616:Vaccinia virus / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D001952:Bridged-Ring Compounds; D013890:Thiourea; D000218:Adamantane
vernacular_title: Virustatisch wirksame N-[Adamantyl-(1)]-thioharnstoffe auf der Basis zyklischer sekundärer Amine 9. Mitteilung: Antivirale Wirkstoffe