[Electronoptical studies of the effect of 1-[p-(methylnitrosamino)-benzylidenamino]-adamantane on the fowl plague virus (FPV) in cell culture].
The adamantanamine derivative 1-[p-(methylnitrosamino)-benzylidenamino]-adamantane (MBAA) at a concentration of 40 microgram/ml demonstrated no effect on adsorption of fowl plague virus (FPV) on chick embryonal cells. The penetration of the virions took place by means of pinocytosis. In the final stages of penetration the virions became gradually disintegrated. Under the influence of MBAA, after break-down of the membrane of pinocytic vesicles a swollen part of the virus core remained in cytoplasm. The morphologically visible replication stages were completely blocked by MBAA. From these results it was concluded that the antiviral action of MBAA most probably depends on a block of virus replication between the final stages of the penetration process and the beginning of production of virus specific structural antigens.
D000218:Adamantane / Q000031:analogs & derivatives / Q000494:pharmacology*; D000327:Adsorption; D000818:Animals; D001952:Bridged-Ring Compounds / Q000494:pharmacology*; D002462:Cell Membrane / Q000382:microbiology; D002467:Cell Nucleus / Q000382:microbiology; D002642:Chick Embryo; D046508:Culture Techniques; D003593:Cytoplasm / Q000382:microbiology; D009980:Influenza A virus / Q000187:drug effects* / Q000254:growth & development / Q000648:ultrastructure; D009602:Nitrosamines / Q000494:pharmacology*; D010873:Pinocytosis; D014779:Virus Replication / Q000187:drug effects
D001952:Bridged-Ring Compounds; D009602:Nitrosamines; D000218:Adamantane
Elektronenoptische Untersuchungen zur Wirkung von 1-[p-(Methylnitrosamino)-benzylidenamino]-adamantan auf das Fowl-Plague-Virus (FPV) in Zellkultur.