[The role of ointment bases in the formulation of 2 antifungal drugs. II. Liberation studies on 5-fluorocytosine and tolnaftate ointment bases by the microbiological agar plate method].
In this study a microbiological in vitro agar plate method was developed to measure the liberation of two antifungal agents; 5-Fluorocytosine and Tolnaftate; comparatively from six different type ointment bases. The effect of dimethylformamide to the liberation of these two antifungals was also studied. Cetyl alcohol ointment and Emulsion ointment (B.P. 1968) bases gave the best results for the two active agents. Dimethylformamide accelerated the release of these antifungals from the emulsion type bases (Emulsion Ointment and Simple Ointment).
D002626:Chemistry, Pharmaceutical; D003596:Cytosine / Q000031:analogs & derivatives; D004058:Diffusion; D005437:Flucytosine; D009823:Ointment Bases; D010592:Pharmaceutic Aids; D014047:Tolnaftate
D009823:Ointment Bases; D010592:Pharmaceutic Aids; D014047:Tolnaftate; D003596:Cytosine; D005437:Flucytosine
Iki antifungal maddenin merhem halinde formülasyonunda merhem sivağlarinin rolü II. Merhemlerden 5--fluorositozin ve tolnaftat'in saliverilmesinin mikrobiyolojik yöntemle araştirilmasi.