Synaptic proteins. Characterization of tubulin and actin and identification of a distinct postsynaptic density polypeptide.
The major proteins in isolated synaptic junctions (SJs) and postsynaptic densities (PSDs) have been compared to actin, tubulin, and the major neurofilament (NF) protein by two-dimensional gel electrophoresis and tryptic peptide map analysis. These studies show: (a) tubulin is present in SJ and PSD fractions and is identical to cytoplasmic tubulin, (b) actin in these fractions is very similar to the gamma- and beta-actin found predominantly in nonmuscle cells, and (c) the major PSD protein is distinct from all other known fibrous proteins.
D000199:Actins / Q000032:analysis*; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D004586:Electrophoresis; D006023:Glycoproteins / Q000032:analysis*; D008970:Molecular Weight; D010455:Peptides / Q000032:analysis; D011506:Proteins / Q000032:analysis*; D051381:Rats; D013569:Synapses / Q000032:analysis*; D014404:Tubulin / Q000032:analysis*
D000199:Actins; D000596:Amino Acids; D006023:Glycoproteins; D010455:Peptides; D011506:Proteins; D014404:Tubulin