[Effect of glycerol formal on the embryonic development of the rat].
In order to evaluate the effect on embryonic development of a solvent commonly used in pharmacological investigations, glycerol formal was administered to pregnant rats from days 6 through 15 of gestation at the daily doses of 0.25, 0.50 and 1.0 ml/Kg i.m. Glycerol formal did not induce systemic toxicity in the mothers, but showed an embryotoxic and teratogenic activity on the products of conception.
D000818:Animals; D004148:Dioxolanes / Q000494:pharmacology*; D004149:Dioxoles / Q000494:pharmacology*; D005260:Female; D011247:Pregnancy; D051381:Rats / Q000196:embryology*; D012997:Solvents; D013723:Teratogens
D004148:Dioxolanes; D004149:Dioxoles; D012997:Solvents; D013723:Teratogens; C025240:glycerol formal
Effetti del glicerolformale sullo sviluppo embrionale del ratto.