[Experimental studies in animals concerning adhesive orchiopexy (author's transl)].
In an experimental study in rabbits, histoxicity of butyl-2-cyano-acrylic-tissue adhesive for orchiopexy was comapred with the usual suture type fixation of the testis. There was no difference in tissue damage between the two methods in respect to local inflammation, diameters of the tubules and the number of spermatogonic cells. Using several established cell lines, a significant cytotoxicity was seen when dropping butyl-2-cyanoacrylic-adhesive into the tissue cultures. Mutagenic influence of butyl-2-cyanoacrylate should be ruled out in children prior to clinical application. In addition, the high cost of the adhesive should be considered.
D000818:Animals; D003487:Cyanoacrylates / Q000633:toxicity*; D004659:Enbucrilate / Q000633:toxicity*; D008297:Male; D009153:Mutagens; D011817:Rabbits; D013093:Spermatogonia; D013737:Testis / Q000187:drug effects* / Q000601:surgery; D014014:Tissue Adhesives
D003487:Cyanoacrylates; D009153:Mutagens; D014014:Tissue Adhesives; D004659:Enbucrilate
Tierexperimentelle Untersuchungen zur Klebeorchidopexie.