[Experimental stereotypy caused by disorders of GABA-ergic mechanisms in the caudate nuclei].
The stereotypy was induced in rats by forming generators of pathologically intensified excitation (GPIE) on local disturbance of the inhibitory mechanisms in rostral portion of caudate nuclei, using bilateral injection of tetanus toxin. Microinjections of gamma-amino-butyric acid (GABA) into the area of the GPIE and systemic galoperidol administration inhibited the stereotypic behaviour of the animals. It is concluded that the formation of the GPIE may lie in the basis of stereotypy due to the disturbances in presynaptic link of the gamkergic system of caudate nuclei, dopaminergic neurons being an operant part of this GPIE.
D000818:Animals; D001519:Behavior / Q000502:physiology*; D002421:Caudate Nucleus / Q000187:drug effects / Q000502:physiology*; D006220:Haloperidol / Q000494:pharmacology; D006801:Humans; D008297:Male; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects / Q000502:physiology*; D013744:Tetanus Toxin; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D013744:Tetanus Toxin; D005680:gamma-Aminobutyric Acid; D006220:Haloperidol
Eksperimental'naia stereotipia, vyzvannaia narusheniem GAMK-ergicheskikh mekhanizmov v khvostatykh iadrakh.