title: Effect of the depletion on brain noradrenaline on the plasma FSH and growth hormone levels in ovariectomized rats.
abstract: The electrolytic lesion of locus coeruleus reduced the hypothalamic noradrenaline (NE) content to 28% of the control values and resulted in a marked decrease of the plasma FSH level in ovariectomized rats before puberty. The local microinjection of 6-OH-dopamine into the locus coeruleus led to a reduction in the hypothalamic NE content to 21% of the control level and induced a decrease of the compensatory ovarian hypertrophy and that of the plasma FSH level. The electrolytic lesion of the locus coeruleus or the 6-OH-dopamine treatment failed to influence the plasma growth hormone (GH) level. The observations support the hypothesis that ventral noradrenergic projection is involved in controlling the pituitary FSH secretion.
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000502:physiology; D002369:Castration; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D013006:Growth Hormone / Q000097:blood*; D006892:Hydroxydopamines / Q000494:pharmacology; D007031:Hypothalamus / Q000378:metabolism; D008125:Locus Coeruleus / Q000502:physiology; D009638:Norepinephrine / Q000378:metabolism* / Q000502:physiology; D051381:Rats
chemical_list: D006892:Hydroxydopamines; D005640:Follicle Stimulating Hormone; D013006:Growth Hormone; D009638:Norepinephrine