[Adrenal cortex production of aldosterone "in vitro" caused by angiotensin II: effects of indomethacin].
Angiotensin II increases aldosterone production of isolated and superfused bovine adrenal glands. Indomethacin shows a bi-phasic effect on the production of the above-mentioned hormone, inhibitory at low doses (0,2 microgram/ml), stimulatory at high doses (5.0 microgram/ml). Preincubation with this drug impedes the increase of aldosterone production induced by angiotensin II. It is likely that the steroidogenetic effect of angiotnesin II is carried out through the PGs.
D000302:Adrenal Cortex / Q000187:drug effects*; D000450:Aldosterone / Q000096:biosynthesis*; D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D002417:Cattle; D004347:Drug Interactions; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology*
D000804:Angiotensin II; D000450:Aldosterone; D007213:Indomethacin
Corticosteroidogenesi aldosteronica "in vitro" da angiotensina II: effetti dell'indometacina.