title: [Changes on platelet adhesion, aggregation and production in course of mumps and mumps meningitis (author's transl)].
abstract: In 20 children with mumps and mumps meningitis thrombocyte functions, the thrombopoiesis and the platelet count were examinated over a four week period. The spontaneous, standardized platelet adhesion and aggregation on silikonized glass surface showed a statistically significant increase from the 5th to the 15th day of the illness. Within the first four days a decrease of the megathrombocyte portion respectively of the youngest platelet forms was noted as revealed by the platelet spreading preparations. Then the thrombopoiesis index as well as the platelet count arised from the 5th day of the illness parallel to the other platelet functions. The enhanced thrombopoiesis diminished at the end of the 3rd week of the illness but the platelet adhesion and aggregation continued to be further increased. A distinct correlation could be established between the development of the specific antibodies and increased platelet adhesion, aggregation and thrombopoiesis in epidemic parotitis. The influence of the immune complexes and of the virus itself, furthermore the occurrence of the regenerating phase as well as the effects of the possible thromboplastic activity following a tissue damage or an inflammatory reaction were discussed.
mesh_terms: D000914:Antibodies, Viral / Q000032:analysis; D001772:Blood Cell Count; D001792:Blood Platelets / Q000502:physiology; D002648:Child; D006801:Humans; D008587:Meningitis, Viral / Q000097:blood*; D009107:Mumps / Q000097:blood*; D010973:Platelet Adhesiveness; D010974:Platelet Aggregation; D013997:Time Factors
chemical_list: D000914:Antibodies, Viral
vernacular_title: Veränderungen von Thrombozytenadhäsion, -aggregation und -neubildung im Verlauf des Mumps und der Mumps-Meningitis.