title: Interaction of phenoxybenzamine with angiotensin II in the isolated perfused rabbit kidney. Short communication.
abstract: Interaction of phenoxybenzamine with angiotensin II was studied in the isolated perfused rabbit kidney. Angiotensin II induced a dose-dependent increase in perfusion pressure and urine flow when given through the renal artery. Phenoxybenzamine when added to the perfusion medium caused a decrease in perfusion pressure but an increase in urine flow. Further addition of acetyl salicylic acid to the perfusion medium significantly reversed both agonistic effects of angiotensin II. The possible mechanisms of these findings are discussed.
mesh_terms: D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D004231:Diuresis / Q000187:drug effects; D004347:Drug Interactions; D066298:In Vitro Techniques; D007668:Kidney / Q000098:blood supply / Q000187:drug effects*; D010477:Perfusion; D010643:Phenoxybenzamine / Q000494:pharmacology*; D011817:Rabbits
chemical_list: D010643:Phenoxybenzamine; D000804:Angiotensin II