The interrelationships between serum 25-hydroxycholecalciferol, serum parathyroid hormone and bone changes in anticonvulsant osteomalacia.
Serum 25-hydroxycholecalciferol (25-HCC) and serum parathyroid hormone (iPTH) were measured in 59 randomly selected adult epileptic outpatients receiving chronic anticonvulsant therapy. Quantitative morphometric analysis of iliac crest biopsies was performed. A mild degree of osteomalacia was found which was inversely correlated to dietary vitamin D intake. Serum 25-HCC was reduced in the epileptic patients compared to a control group, although dietary intake of vitamin D was higher than the mean daily intake in the Danish population. Serum 25-HCC was positively correlated to dietary vitamin D intake, but not correlated to the severity of bone changes, indicating that other factors than circulating 25-HCC are responsible for the development of anticonvulsant osteomalacia. Serum 25-HCG was inversely correlated to serum iPTH in patients with a low dietary calcium intake. The mean value of serum iPTH was not increased, and there was no correlation between serum iPTH and bone morphometry.
D000293:Adolescent; D000328:Adult; D001667:Binding, Competitive; D002136:Calcium, Dietary; D004827:Epilepsy / Q000097:blood / Q000188:drug therapy; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D006887:Hydroxycholecalciferols / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010018:Osteomalacia / Q000097:blood / Q000139:chemically induced*; D010281:Parathyroid Hormone / Q000097:blood*; D010672:Phenytoin / Q000009:adverse effects* / Q000627:therapeutic use; D014807:Vitamin D
D002136:Calcium, Dietary; D006887:Hydroxycholecalciferols; D010281:Parathyroid Hormone; D014807:Vitamin D; D010672:Phenytoin