title: [Immunologic studies with fully synthetic human insulin in patients with diabetes mellitus].
abstract: A group of 12 diabetic patients with insulin allergy previously documented by positive skin tests have been investigated with insulin of bovine, porcine and human origin and with a synthetic human insulin (CGP 12 831). In 3 patients clearly positive skin tests were found even against CGP 12 831. In lymphocyte transformation tests performed in these 3 cases, an increase of 3H-thymidine uptake was found when Actrapid was added. No increase was observed when CGP 12 831 was added.
mesh_terms: D000818:Animals; D002417:Cattle / Q000276:immunology; D003920:Diabetes Mellitus / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D007328:Insulin / Q000138:chemical synthesis / Q000276:immunology*; D008213:Lymphocyte Activation; D012882:Skin Tests; D013552:Swine / Q000276:immunology
chemical_list: D007328:Insulin
vernacular_title: Immunologische Untersuchungen mit vollsynthetischem humanem Insulin bei Patienten mit Diabetes mellitus.