A new trend in non-infectious immunology-investigation of the biological role of natural anti-tissue antibodies in humans and animals.
The author analysis a number of studies of Soviet and foreign investigators demonstrating the presence of natural anti-tissue antibodies in healthy human and animals. A large number of these antibodies appear during and they occur more frequently and in larger amounts in females than in males. The physiological function of these antibodies which influence the permeability of tissues, their metabolism and their role in the removal and neutralization of the products of cell disintegration and metabolism, are discussed. Emphasis is laid on the participation of normal autoantibodies in the resistance of the organism of tumours and to radiation, discovered in the last few years. The studies dealing with the detection of activators--inductors of normal autoantibodies and with the role of their effect in specific immune response are mentioned. Thus the review elucidates the theoretical and practical perspectives of exploring this new trend in immunology.
D000368:Aged; D000375:Aging; D000818:Animals; D001323:Autoantibodies / Q000032:analysis / Q000276:immunology; D005260:Female; D006801:Humans; D007109:Immunity; D008297:Male; D051379:Mice; D009369:Neoplasms / Q000276:immunology; D011817:Rabbits; D011833:Radiation Injuries, Experimental / Q000276:immunology; D051381:Rats
D001323:Autoantibodies