title: Behavioral effects of neuroleptics, apomorphine and amphetamine after bilateral lesion of the locus coeruleus in rats.
abstract: Bilateral lesions of the locus coeruleus (LC) markedly increased susceptibility to the cateleptogenic effects of neuroleptics. The apomorphine-induced stereotypy was enhanced in rats with lesioned LC whilst amphetamine stereotypy was only slightly increased. No changes in locomotor activity have been observed in LC-lesioned rats treated with apomorphine and amphetamine. This data indicates that lesions of the LC produce decreased activity of dopaminergic brain neurons as well as supersensitivity of dopaminergic receptors.
mesh_terms: D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001519:Behavior / Q000187:drug effects*; D001679:Biogenic Amines / Q000032:analysis; D001923:Brain Chemistry / Q000187:drug effects; D002090:Butyrophenones / Q000494:pharmacology*; D003913:Dextroamphetamine / Q000494:pharmacology*; D006220:Haloperidol / Q000494:pharmacology*; D006801:Humans; D008125:Locus Coeruleus / Q000033:anatomy & histology / Q000502:physiology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D013134:Spiperone / Q000494:pharmacology*; D013239:Stereotyped Behavior / Q000187:drug effects*; D013997:Time Factors
chemical_list: D001679:Biogenic Amines; D002090:Butyrophenones; D013134:Spiperone; D006220:Haloperidol; D001058:Apomorphine; D003913:Dextroamphetamine