Isoflurane anesthesia and pressure antagonism in mice.
The anesthetic partial pressure causing a loss of righting reflex in mice (ED50) was determined for isoflurane at ambient total pressures ranging from 1 to 100 atmospheres absolute (ATA). The higher pressures, produced by adding helium, decreased isoflurane's apparent anesthetic effect: 48 percent more was needed at 100 ATA. This is consistent with previous work with N2O, where a 46 percent increase was found. The ED50 for isoflurane at 1 ATA is 0.0057 ATA, only 29 percent of that predicted by the Meyer-Overton relationship for mice.
D000769:Anesthesia, Inhalation; D000818:Animals; D001274:Atmospheric Pressure; D006371:Helium; D007530:Isoflurane / Q000494:pharmacology; D008297:Male; D008738:Methyl Ethers / Q000494:pharmacology; D051379:Mice; D011312:Pressure; D012018:Reflex / Q000187:drug effects
D008738:Methyl Ethers; D006371:Helium; D007530:Isoflurane