[Stimulating effect of schizophrenic patients' plasma on the cellular incorportation of tryptophan in vitro].
A study of 21 schizophrenic patients and 21 normal donors in one experiment, conducted on a pool or erythrocytes in 18 chickens with the use of a double blind method, confirmed the previously obtained data of the stimulant action of plasma in schizophrenic patients on the uptake of tryptophan by chicken erythrocytes. It was demonstrated, that the plasma at the same time evokes an increase of cytoplasmatic enzymes (lactate dehydrogenase and myokynase). The authors studied the correlations between the influence of plasma on the tryptophan uptake and the release of hemoglobin from the erythrocytes and its concentration in the incubation medium. The data also demonstrate the parameters of functions describing the first correlation and that it has a nonmonotonous character. The problem of the connection between the plasma action on the tryptophane uptake and its hemolytic activing is discussed.
D000263:Adenylate Kinase / Q000378:metabolism; D000328:Adult; D000818:Animals; D002645:Chickens / Q000097:blood; D003402:Creatine Kinase / Q000378:metabolism; D004912:Erythrocytes / Q000201:enzymology / Q000378:metabolism*; D005260:Female; D006461:Hemolysis; D006801:Humans; D007106:Immune Sera / Q000494:pharmacology*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000097:blood*; D014364:Tryptophan / Q000378:metabolism*
D007106:Immune Sera; D014364:Tryptophan; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase; D000263:Adenylate Kinase
Izuchenie stimuliruiushchego deĭstviia plazmy bol'nykh shizofrenieĭ na kletochnoe vkliuchenie triptofana in vitro.