title: Characterisation of serum fibrinogen degradation products using gel chromatography and radioimmunoassay.
abstract: Fibrin(ogen) degradation products (FDP) are detected by radioimmunoassay in the serum of all subjects. Some of these FDPs have considerable biological activity in vivo, and hence may play a significant part in the process of coagulation. Chromatography of serum samples from patients including those with pulmonary emboli and deep venous thrombosis indicates that the majority of non-clottable fibrin(ogen)-related antigen present is of high molecular weight--greater than that of fibrinogen--and that in pathological situations there is a quantitative increase not a qualitative alteration in the molecular species present.
mesh_terms: D002850:Chromatography, Gel; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products; D006801:Humans; D008297:Male; D008970:Molecular Weight; D011247:Pregnancy; D011655:Pulmonary Embolism / Q000097:blood; D011863:Radioimmunoassay; D013924:Thrombophlebitis / Q000097:blood
chemical_list: D005338:Fibrin Fibrinogen Degradation Products