Water soluble vitamins in patients with chronic renal failure and effect of B6 administration of immunological activity.
Blood concentrations of water soluble vitamins were studied in 29 undialyzed and 35 dialyzed patients with CRF, and 36 healthy volunteers. Effects of B6 administration on immunological parameters were studied in dialyzed patients. In dialyzed patients, whole blood B1 decreased, while plasma B2, B6 and serum B12 and folic acid increased. In undialyzed patients with uremia, plasma B2, serum B12 and folic acid increased, while plasma C decreased in patients with moderate CRF. Oral administration of B6 for 4 wks was associated with improved tuberculin skin tests and PHA mitogen responses in dialyzed patients. Supplementation of B1 is required for patients with CRF while B6 and C may be considered.
D001205:Ascorbic Acid / Q000097:blood; D005492:Folic Acid / Q000097:blood; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000276:immunology / Q000628:therapy; D008214:Lymphocytes / Q000276:immunology; D011736:Pyridoxine / Q000008:administration & dosage* / Q000097:blood; D006435:Renal Dialysis; D012256:Riboflavin / Q000097:blood; D013831:Thiamine / Q000097:blood; D014374:Tuberculin Test; D014805:Vitamin B 12 / Q000097:blood; D014815:Vitamins / Q000097:blood*
D014815:Vitamins; D005492:Folic Acid; D011736:Pyridoxine; D014805:Vitamin B 12; D001205:Ascorbic Acid; D012256:Riboflavin; D013831:Thiamine