Scleroderma-inducing glycosaminoglycan in the urine of patients with systemic scleroderma.
A glycosaminoglycan with scleroderma-inducing effect was isolated and partially purified from the urine of patients with systemic scleroderma. The glycosaminoglycan was an N-sulfated glycosaminoglycuronan and its high total sulfate and 2,5-anhydromannose contents suggest that the glycosaminoglycan is a degradation product of heparin or polysulfated heparin sulfate. Furthermore, the composition of the above glycosaminoglycan was similar to that of the N-sulfated glycosaminoglycan which we observed previously in uninvolved skin of scleroderma.
D000328:Adult; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D005260:Female; D006025:Glycosaminoglycans / Q000032:analysis / Q000302:isolation & purification / Q000652:urine*; D006801:Humans; D008297:Male; D051379:Mice; D008875:Middle Aged; D012595:Scleroderma, Systemic / Q000139:chemically induced / Q000473:pathology / Q000652:urine*; D012867:Skin / Q000187:drug effects / Q000473:pathology; D013431:Sulfates / Q000032:analysis
D000596:Amino Acids; D006025:Glycosaminoglycans; D013431:Sulfates