Desmosomal abnormalities in the liver of methotrexate-treated psoriatics.
Electron microscopy of the liver of methotrexate-treated psoriatic patients revealed junctional abnormalities consisting of detachment of desmosomal plaques between hepatocytes. Mitochondria anchoring desmosomal microfilaments were frequently noted.
D003599:Cytoskeleton / Q000648:ultrastructure; D003896:Desmosomes / Q000187:drug effects / Q000648:ultrastructure; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000648:ultrastructure; D008727:Methotrexate / Q000009:adverse effects* / Q000627:therapeutic use; D008854:Microscopy, Electron; D008930:Mitochondria, Liver / Q000187:drug effects / Q000648:ultrastructure; D011565:Psoriasis / Q000188:drug therapy
D008727:Methotrexate