Interaction of fibrinopeptides A and B with dopaminergic receptors in central nervous system.
The effect of fibrinopeptides A and B (FAB) on the action of compounds affecting the dopaminergic receptors in central nervous system (CNS) of rats was investigated. These peptides given intraperitoneally (ip) or intraventricularly (ivc) exerted dose-dependent stimulatory effects on the CNS: Enhanced the apomorphine and amphetamine-induced stereotypies and reduced the catalepsy induced by haloperidol. FAB depressed the dopamine level, especially when given together with alpha-MT, and elevated the level of homovanillic acid in the striatum. The results suggest that the stimulatory effects of FAB depend on their interaction with dopaminergic receptors in the CNS.
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D002490:Central Nervous System / Q000187:drug effects*; D004347:Drug Interactions; D005338:Fibrin Fibrinogen Degradation Products / Q000494:pharmacology*; D006801:Humans; D007140:Immunoglobulin Fab Fragments; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects*; D013239:Stereotyped Behavior / Q000187:drug effects; D013268:Stimulation, Chemical; D013997:Time Factors
D005338:Fibrin Fibrinogen Degradation Products; D007140:Immunoglobulin Fab Fragments; D011954:Receptors, Dopamine; D000661:Amphetamine