Effect of live attenuated vaccines on the course of experimental allergic encephalomyelitis. A pilot study.
The clinical severity of EAE is enhanced by pre-treatment with distemper, measles and BCG vaccine, measles vaccine gives a more severe onset of disease. Rubella vaccine and TAB leads to mild disease which recurs on re-treatment with the appropriate vaccine. These findings and their possible significance in MS are briefly discussed.
D000818:Animals; D001500:BCG Vaccine / Q000008:administration & dosage; D004216:Distemper; D004285:Dogs; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology*; D006168:Guinea Pigs; D007114:Immunization; D008458:Measles Vaccine / Q000008:administration & dosage; D009103:Multiple Sclerosis / Q000209:etiology; D010865:Pilot Projects; D012411:Rubella Vaccine / Q000008:administration & dosage; D014436:Typhoid-Paratyphoid Vaccines / Q000008:administration & dosage; D014613:Vaccines, Attenuated / Q000494:pharmacology*
D001500:BCG Vaccine; D008458:Measles Vaccine; D012411:Rubella Vaccine; D014436:Typhoid-Paratyphoid Vaccines; D014613:Vaccines, Attenuated