title: Combination of two techniques: amniocentesis and nervous tissue explants. A pilot investigation.
abstract: Addition of serum derived from amniotic fluid cells (AFS) from Tay Sachs carrier to developing mouse cerebral cortex explants results in excessive accumulation of lipid in neuronal cytoplasm.
mesh_terms: D000649:Amniocentesis / Q000379:methods; D000818:Animals; D002454:Cell Differentiation; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000166:cytology; D005260:Female; D006801:Humans; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods*; D013661:Tay-Sachs Disease / Q000175:diagnosis* / Q000503:physiopathology