Intoxication caused by interaction of chloramphenicol and phenytoin.
A patient with a brain tumor and seizures who was receiving maintenance doses of phenytoin was given chloramphenicol on three occasions. Her neurological status was both complicated and obscured by the reoccurrence of phenytoin intoxication. Retrospective drug analysis showed a marked elevation of serum concentrations of phenytoin during each course of chloramphenicol.
D002701:Chloramphenicol / Q000494:pharmacology* / Q000627:therapeutic use; D004347:Drug Interactions; D005260:Female; D006392:Hemangioma, Cavernous / Q000188:drug therapy; D006801:Humans; D008875:Middle Aged; D010672:Phenytoin / Q000097:blood / Q000506:poisoning* / Q000627:therapeutic use; D012658:Sella Turcica; D012769:Shock / Q000188:drug therapy; D013268:Stimulation, Chemical
D010672:Phenytoin; D002701:Chloramphenicol