Effect of substance P on pulmonary resistance and dynamic pulmonary compliance in the anaesthetized cat and guinea-pig.
The effect of substance P, acetylcholine, and histamine on pulmonary resistance (RL) and on pulmonary dynamic compliance (CDYN) was studied in the anaesthetized cat and guinea-pig. In the anaesthetized guinea-pig, substance P (0.1-1.0 microgram/kg) acetylcholine (1.0-10 microgram/kg), and histamine (1.0-10.0 microgram/kg) produced a dose-dependent increase in RL and decrease in CDYN. In the anaesthetized cat, the effect of substance P was weak on both RL and CDYN, whereas histamine (5-50 microgram/kg) produced a dose-dependent increase in CDYN, but the effect on RL was weak. The effect of acetylcholine was qualitatively the same as in the anaesthetized guinea-pig but about 10 times less effective.
D000109:Acetylcholine / Q000008:administration & dosage / Q000494:pharmacology; D000403:Airway Resistance / Q000187:drug effects*; D000768:Anesthesia, General; D000818:Animals; D002415:Cats; D004305:Dose-Response Relationship, Drug; D005260:Female; D006168:Guinea Pigs; D006632:Histamine / Q000008:administration & dosage / Q000494:pharmacology; D008170:Lung Compliance / Q000187:drug effects*; D008297:Male; D013373:Substance P / Q000008:administration & dosage / Q000494:pharmacology*
D013373:Substance P; D006632:Histamine; D000109:Acetylcholine