Suppression of phosphorylcholine-specific IgE antibody formation in BALB/c mice by isologous anti-T 15 antiserum.
In order to study the regulation of IgE antibody formation, isologous anti-idiotypic antisera against the phosphoryl choline (PC)-specific BALB/c myeloma proteins T 15 and M 167 were passively administered to BALB/c in the course of an anti-PC IgE response. Isologous anti-T 15 antiserum had a long-lasting suppressive effect on the formation of IgE antibodies with PC specificity, whereas administration of anti-M 167 antiserum had no or only little effect, similar to that of normal BALB/c serum. This indicates that anti-PC IgE antibodies consist mainly of the T 15 idiotype or of cross-reacting idiotypes, and that IgE response is accessible to regulation with anti-idiotypic antibodies. This murine model may permit the study of regulation of an IgE response largely restricted to few defined idiotypes characterized as tumor proteins.
D000818:Animals; D000917:Antibody Formation; D002794:Choline / Q000031:analogs & derivatives*; D005260:Female; D007106:Immune Sera / Q000096:biosynthesis; D007073:Immunoglobulin E / Q000096:biosynthesis*; D007130:Immunoglobulin Idiotypes; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology*; D009194:Myeloma Proteins / Q000276:immunology; D010767:Phosphorylcholine / Q000276:immunology*
D007106:Immune Sera; D007130:Immunoglobulin Idiotypes; D009194:Myeloma Proteins; D010767:Phosphorylcholine; D007073:Immunoglobulin E; D002794:Choline