Metabolism of N-nitroso-2-oxopropylpropylamine by rat liver: formation of products resulting from both oxidation and reduction.
Metabolism of N-nitroso-2-oxopropylpropylamine (NOPPA) with either a microsomal preparation or the soluble enzyme fraction from rat liver yielded N-nitroso-2-hydroxypropylpropylamine (NHPPA). We have also identified and quantified propionaldehyde, n-propanol and isopropanol following incubation of NOPPA with the microsomal fraction.
D000433:1-Propanol / Q000378:metabolism; D000447:Aldehydes / Q000378:metabolism; D000818:Animals; D003600:Cytosol / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D009602:Nitrosamines / Q000378:metabolism; D010084:Oxidation-Reduction; D051381:Rats
D000447:Aldehydes; D009602:Nitrosamines; C016509:2-hydroxypropyl-n-propylnitrosamine; C016637:2-oxopropyl-n-propylnitrosamine; D000433:1-Propanol; C005556:propionaldehyde