title: [On the pharmacology of piprozoline (author's transl)].
abstract: Ethyl (Z)-(3-ethyl-4-oxo-5-piperidino-thiazolidin-2-ylidene)- acetate (piprozoline, Gö 919, Problin) is a new potent choleretic which can be classified as a true cholepoietic agent. Accordingly the substance increases bile fluid and solid content as well. A dose-dependent choleretic effect could be shown in all species investigated. The choleretic effect of piprozoline is long-lasting and superior to that of the other choleretics compared with. There was a significant inhibition of experimentally induced liver damage in animals by piprozoline given prophylactically. Our experiments did not reveal any pharmacological properties interfering with the use of piprozoline as a choleretic.
mesh_terms: D000546:Amanitins / Q000009:adverse effects; D000818:Animals; D001646:Bile / Q000378:metabolism; D001647:Bile Acids and Salts / Q000378:metabolism; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy; D002415:Cats; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy / Q000209:etiology; D002756:Cholagogues and Choleretics / Q000633:toxicity; D004285:Dogs; D005260:Female; D005688:Galactosamine / Q000009:adverse effects; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010880:Piperidines / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D013844:Thiazoles / Q000494:pharmacology* / Q000633:toxicity
chemical_list: D000546:Amanitins; D001647:Bile Acids and Salts; D002756:Cholagogues and Choleretics; D010880:Piperidines; D013844:Thiazoles; D005688:Galactosamine
vernacular_title: Zur Pharmakologie von Piprozolin