Alkali metal cations: effects on isolation-induced aggression in the mouse.
Alkali metal cations were given in varying doses over 14 days to CF-1, male mice, isolated for 4 weeks prior to testing for isolation-induced fighting. Lithium and cesium in doses of 4.5 and 6.0 meq/kg reduced the duration of isolation-induced aggression in a 15 min test period when compared with controls. Toxicity was evident in the cesium-treated, but not the lithium-treated mice. No enhancement of aggression was seen in the rubidium-treated group.
D000374:Aggression / Q000187:drug effects*; D000818:Animals; D002586:Cesium / Q000494:pharmacology; D006801:Humans; D008094:Lithium / Q000494:pharmacology; D008297:Male; D008670:Metals / Q000494:pharmacology*; D051379:Mice; D011188:Potassium / Q000494:pharmacology; D012413:Rubidium / Q000494:pharmacology; D012934:Social Isolation; D012964:Sodium / Q000494:pharmacology; D013997:Time Factors
D008670:Metals; D002586:Cesium; D008094:Lithium; D012964:Sodium; D012413:Rubidium; D011188:Potassium