[Cellular immunity in patients with Hodgkin's disease: modification induced by incubating lymphocytes with fetal calf serum and Hodgkin's serum].
The capacity of peripheral blood lymphocytes from fifteen patients with untreated Hodgkin's disease to form E-rosettes with sheep erytrocytes and to respond to PHA stimulation was found to be impaired in 47% of patients. When peripheral blood lymphocytes were incubated overnight in culture medium containing 20% fetal calf serum, E-RFC levels and the capacity to respond to PHA returned to normal. These functions were resuppressed by additional incubation with Hodgkin's disease serum but not from normal serum. The Hodgkin's disease serum inhibited normal peripheral blood lymphocytes to form E-rosettes and to respond to PHA.
D000818:Animals; D002417:Cattle; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D005333:Fetus / Q000276:immunology; D006689:Hodgkin Disease / Q000097:blood / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D008213:Lymphocyte Activation; D010835:Phytohemagglutinins / Q000494:pharmacology; D011247:Pregnancy; D012397:Rosette Formation; D012756:Sheep
D010835:Phytohemagglutinins
Studio della risposta cellulare immune nei pazienti con morbo di Hodgkin: modificazioni indotte dall'incubazione dei linfociti con siero fetale di vitello e con siero di Hodgkin.