title: Generic propoxyphene: need for clinical bioavailability evaluation.
abstract: Plasma level data on two investigational capsule formulations of propoxyphene with similar physicochemical parameters demonstrate that the formulations have different in vivo bioavailabilities. The potential bioavailability problems with water-soluble drugs and the lack of correlation of in vitro and in vivo parameters for equivalent drug formulations are discussed.
mesh_terms: D000328:Adult; D001682:Biological Availability; D002214:Capsules; D011431:Dextropropoxyphene / Q000008:administration & dosage / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013810:Therapeutic Equivalency
chemical_list: D002214:Capsules; D011431:Dextropropoxyphene