Immunoglobulin-binding structure on bovine group G streptococci different from type III Fc receptors on human group G streptococci.
The immunoglobulin G (IgG)-binding capacity of 54 group G streptococci of human and bovine origin was investigated. Of 20 human strains, 17 carried a surface component which could combine with human IgG and bovine IgG1 and IgG2. Inhibition experiments with unlabeled human IgG and with a panel of animal sera revealed that the same surface component was involved in the binding of human as well as bovine immunoglobulins. Of 16 beta-hemolytic bovine group G streptococci, 13 reacted with human IgG but not with bovine IgG1 or IgG2. This binding structure was different from the type III Fc reactivity found in human group G streptococci. All human strains, including the three IgG Fc-nonreactive strains, fermented trehalose, in contrast to all bovine beta-hemolytic strains, which were negative. Immunoglobulin Fc reactivity is thus a feature not only of human strains but also of some bovine strains.
D000818:Animals; D001665:Binding Sites; D002417:Cattle; D006801:Humans; D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G / Q000276:immunology*; D013045:Species Specificity; D013291:Streptococcus / Q000276:immunology* / Q000378:metabolism
D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G