Regulation of protein synthesis by estradiol-17beta in cultured hepatocytes.
Estradiol-17beta added to cultured chick embryo hepatocytes induced the appearance in the medium of a phosphoprotein, identified as phosvitin on the basis of: (i) its behaviour on ionic exchange columns; (ii) its SDS-acrylamide gel electrophoretic mobility; (iii) its amino acid composition. The hormone treatment was also followed by a decreased synthesis of other proteins secreted by the hepatocytes.
D000818:Animals; D002478:Cells, Cultured; D002642:Chick Embryo; D004958:Estradiol / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D010750:Phosphoproteins / Q000096:biosynthesis*; D010774:Phosvitin / Q000096:biosynthesis; D013268:Stimulation, Chemical; D014819:Vitellogenins / Q000096:biosynthesis
D010750:Phosphoproteins; D014819:Vitellogenins; D004958:Estradiol; D010774:Phosvitin