Mammalian spot test with moxnidazole, a 5-nitroimidazole.
Moxnidazole [3-(5-nitrol-1-methyl-2-imidazolyl)-methyleneamino-5-morpholinomethyl-2-oxazolidinone, HCl], known to be mutagenic in microbial tests and Drosophila, induced genetic alterations in somatic cells of mice. Ethyl methanesulfonate (EMS) served as positive control.
D000818:Animals; D004622:Embryo, Mammalian / Q000187:drug effects*; D005260:Female; D005838:Genotype; D051379:Mice; D009153:Mutagens; D009593:Nitroimidazoles / Q000494:pharmacology*; D010080:Oxazoles / Q000494:pharmacology*; D023303:Oxazolidinones; D010858:Pigmentation / Q000187:drug effects*; D011247:Pregnancy
D009153:Mutagens; D009593:Nitroimidazoles; D010080:Oxazoles; D023303:Oxazolidinones; C013139:moxnidazole