[Mechanisms of the hyporeactivity occurring in mice after the administration of the antigen of lysed erythrocytes].
Specific hyporeactivity state to SRBC was induced in mice by injection of SRBC hemolysate. The blocking serum factor in such mice was not identical by the action character to the antierythrocytic antibodies, possibly representing the antigen-antibody complex. In combined administration to mice of the SRBC hemolysate and cyclophosphamide (CP) production of the blocking serum factor was found to be suppressed; however the mouse reactivity to SRBC proved to be considerably decreased. It is suggested that in this case there occurs inactivation of immuno-competent cells as a result of combined action of CP and the antigen on the SRBC in the nonimmunogenic form.
D000818:Animals; D000906:Antibodies / Q000276:immunology; D000921:Antibody-Producing Cells / Q000276:immunology; D000936:Antigen-Antibody Complex; D000937:Antigen-Antibody Reactions; D000941:Antigens / Q000008:administration & dosage*; D004912:Erythrocytes / Q000276:immunology*; D006461:Hemolysis; D007106:Immune Sera / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D013997:Time Factors
D000906:Antibodies; D000936:Antigen-Antibody Complex; D000941:Antigens; D007106:Immune Sera
O mekhanizmakh giporeaktivnosti, voznikaiushcheĭ u mysheĭ posle vvedeniia antigena lizirovannykh éritrotsitov.