Effect of hydrolyzed formaldehyde-treated RNA on neoplastic and normal human cells.
Alkaline hydrolysate of dialyzed formaldehyde-treated RNA, in which 39% of purine nucleotides are modified to methylene bis derivatives (R-CH2-R'), displays cytotoxic activity toward cultured human tumor cells. The alkaline hydrolysate of dialyzed formaldehyde-treated RNA is substantially less toxic to normal human embryonic cells. There is a correlation between the cytotoxic effect and cell growth rate, which has been traced by quantitative tests.
D000970:Antineoplastic Agents; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D004622:Embryo, Mammalian; D005557:Formaldehyde; D006801:Humans; D006868:Hydrolysis; D009369:Neoplasms; D012313:RNA / Q000494:pharmacology*
D000970:Antineoplastic Agents; D005557:Formaldehyde; D012313:RNA