Megakaryocytes in the giant platelet syndrome. A cytochemical and ultrastructural study.
When compared to normal megakaryocytes, those from a patient with the giant platelet syndrome exhibited numerous cytochemical abnormalities. These reflected disturbances in the metabolism of RNA, glycogen, arginine-rich histone, and various glycolytic enzymes. Ultrastructural studies of the abnormal megakaryocytes also showed decreased glycogen and RNA (ribosomes) as well as aberrations of nuclear lobulation.
D001791:Blood Platelet Disorders; D001792:Blood Platelets / Q000473:pathology*; D004950:Esterases / Q000097:blood; D006003:Glycogen / Q000097:blood; D006651:Histocytochemistry; D006657:Histones / Q000097:blood; D006801:Humans; D008297:Male; D008533:Megakaryocytes / Q000378:metabolism / Q000473:pathology*; D008854:Microscopy, Electron; D008875:Middle Aged; D012313:RNA / Q000097:blood; D013577:Syndrome; D013921:Thrombocytopenia / Q000097:blood / Q000473:pathology*
D006657:Histones; D012313:RNA; D006003:Glycogen; D004950:Esterases