[The "stimulatory proteodyschylia" in the amitriptylin (Laroxyl) treated rat parotid gland. Experiments on the effect of antidepressive pharmacotherapy on the parotid glands of the rat (author's transl)].
The activity of total amylase and isoamylases in the rat parotid gland is reduced by treatment with Amitriptylin (Laroxyl) for 3 and 7 days while the protein content of the glands remains constant. These changes are no longer visible after treatment for 21 days and following a period without drug application. To differentiate the disturbances of protein secretion (proteodyschylia) prominent in the clinical picture of sialadenosis, the following classification is proposed. We suggest the term "stimulatory proteodyschylia" for a decrease of acinar amylolytic activity, here caused by Amitriptylin application, as opposed to the "inhibitory proteodyschylia" characterized by an acinar amylase congestion.
D000639:Amitriptyline / Q000008:administration & dosage / Q000494:pharmacology*; D000681:Amylases / Q000378:metabolism; D000818:Animals; D005260:Female; D007517:Isoamylase / Q000378:metabolism; D010306:Parotid Gland / Q000187:drug effects* / Q000201:enzymology; D051381:Rats; D012471:Salivary Proteins and Peptides / Q000378:metabolism*
D012471:Salivary Proteins and Peptides; D000639:Amitriptyline; D000681:Amylases; D007517:Isoamylase
Die "stimulatorische Proteodyschylie" in der Amitriptylin (Larozyl)-behandelten Rattenparotis. Tierexperimentelle Untersuchungen über die Auswirkung einer antidepressiven Pharmakotherapie auf die Ohrspeicheldrüsen.