On the mechanism of accumulation of 67Ga by tumors.
There is strong experimental evidence indicating that a competitive binding of 67Ga3+ to Ca2+- and Mg2+-binding sites rather than a metabolic process is involved in the accumulation of this radioisotope. These observations suggest that in tumors, as well as in other inflammatory and infectious processes, the most important role in 67Ga accumulation is played by a higher availability of those binding sites than in normal tissue.
D000818:Animals; D001665:Binding Sites; D001667:Binding, Competitive; D002113:Calcification, Physiologic; D002118:Calcium / Q000378:metabolism; D005710:Gallium Radioisotopes; D007942:Leukemia, Experimental / Q000378:metabolism*; D007945:Leukemia, Lymphoid / Q000378:metabolism; D008228:Lymphoma, Non-Hodgkin / Q000378:metabolism*; D008274:Magnesium / Q000378:metabolism; D051379:Mice; D008806:Mice, Inbred AKR; D008809:Mice, Inbred C3H; D012513:Sarcoma, Experimental / Q000378:metabolism
D005710:Gallium Radioisotopes; D008274:Magnesium; D002118:Calcium