Localisation of the NADPH delta 4-3-keto steroid-5 alpha-oxidoreductase in the rat ovary.
The 5 alpha-reductase activity was localised on the stromal comportment of the rat ovary. The 5 alpha-reductase activity in stromal tissue decreased from 27.3 +/- 2.9 ng/hr/mg protein in rats 20 days old, to 13.4 +/- 1.2 ng/hr/mg protein in rats 30 days old and to 7.1 +/- 1.0 ng/hr/mg protein in adult rats. During the oestrous cycle no significant variations in enzyme activity could be demonstrated.
D015096:3-Hydroxysteroid Dehydrogenases / Q000378:metabolism; D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase / Q000378:metabolism*; D000375:Aging; D000818:Animals; D004971:Estrus; D005260:Female; D010053:Ovary / Q000201:enzymology* / Q000254:growth & development; D010088:Oxidoreductases / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats
D010088:Oxidoreductases; D015096:3-Hydroxysteroid Dehydrogenases; D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase