The effects of D-histiding on the expression of morphine tolerance and physical dependence in mice.
D-Histidine, administered in the 'wthdrawal' phase of morphine addiction, failed to modify the expression of tolerance and physical dependence in mice. L-Histidine, on the contrary, can enhance tolerance and inhibit physical dependence. Whole brain histamine is markedly increased by L-histidine administration, but only minimally by D-histidine. This confirms that the actions of L-histidine on morphine addiction are stereospecific, and so can be more confidently correlated with the increase in brain histamine levels produced by the natural amino acid precursor.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D004361:Drug Tolerance; D006632:Histamine / Q000378:metabolism; D006639:Histidine / Q000494:pharmacology*; D006801:Humans; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009020:Morphine / Q000494:pharmacology*; D009021:Morphine Dependence / Q000378:metabolism / Q000503:physiopathology*; D011930:Reaction Time / Q000187:drug effects; D013375:Substance Withdrawal Syndrome / Q000378:metabolism / Q000503:physiopathology
D006639:Histidine; D009020:Morphine; D006632:Histamine