[Aspects of the decrease of some enzyme activities in erythrocytes of subjects with beta-thalassemia].
G6PD, GSH-Px and 6PGD activity was found to be elevated in beta-thalassemia heterozygous erythrocytes. Estimates of the activities of the three enzymes in red cell fractions of differing mean age separated by centrifugation through a density gradient of Ficoll-Triosil layers, showed that the rate of in vivo decline was normal for G6PD and GSH-Px, and decreased for 6PGD. The increased enzyme activity results from increased rate of synthesis for G6PD and GSH-Px, and from higher in vivo stability for 6PGD.
D004912:Erythrocytes / Q000201:enzymology*; D005954:Glucosephosphate Dehydrogenase / Q000097:blood*; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D010544:Peroxidases / Q000097:blood*; D010734:Phosphogluconate Dehydrogenase / Q000097:blood*; D013789:Thalassemia / Q000201:enzymology*
D010734:Phosphogluconate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D010544:Peroxidases; D005979:Glutathione Peroxidase
Aspetti del decadimento di albune attivita' enzimatiche in eritrociti di soggetti beta-talassemici.