title: The stimulation of prolactin secretion by sulpiride in "adolescent gynaecomastia".
abstract: In order to evaluate the function of the hypothalamic-pituitary-prolactin axis in "adolescent gynaecomastia" (AG), sulpiride was administered to 7 normal boys and 7 boys with AG. The maximum increase in serum prolactin (PRL) above the mean baseline level (deltamax) was used as index of response. The sulpiride induced a greater PRL release in boys with gynaecomastia than in the controls. Our data indicate that boys with gynaecomastia may have a greater pituitary prolactin pool. The results also illustrate the usefulness of specific neurotrophic agents such as sulpiride as important tools for evaluating the function of the hypothalamic-pituitary-PRL axis.
mesh_terms: D000293:Adolescent; D000328:Adult; D006177:Gynecomastia / Q000503:physiopathology*; D006801:Humans; D008297:Male; D010903:Pituitary Gland, Anterior / Q000503:physiopathology; D011388:Prolactin / Q000097:blood / Q000378:metabolism*; D012636:Secretory Rate / Q000187:drug effects; D013268:Stimulation, Chemical; D013469:Sulpiride
chemical_list: D013469:Sulpiride; D011388:Prolactin