Effect of signaled versus unsignaled stress of rat myocardium.
Foot-shock stress resulted in a threefold increase in myocardial uptake of technetium-99m-methylene diphosphonate (Tc-99m-MDP) in rats compared to unstressed controls. The introduction of a 4-sec signal prior to each shock resulted in a two-thirds reduction in this stress-induced Tc-99m-MDP myocardial uptake, suggesting that most of the stress-induced myocardial damage was psychologically mediated.
D000818:Animals; D004597:Electroshock; D006801:Humans; D008297:Male; D008954:Models, Biological; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D013315:Stress, Psychological / Q000378:metabolism*; D013667:Technetium / Q000378:metabolism; D013997:Time Factors
D013667:Technetium