title: Anomalous Ullman additions with 2-chloronicotinic acid and pharmacological properties of isonixine, a new anti-inflammatory drug.
abstract: An anomalous Ullman reaction with 2-chloronicotinic acid is described. The resulting product 2',6'-di-methyl-anilide of 2-pyridone-3-carboxylic acid (isonixine) presents very interesting pharmacological properties as a potential analgesic-anti-inflammatory agent. Chemical and pharmacological data are given.
mesh_terms: D000284:Administration, Oral; D000700:Analgesics / Q000138:chemical synthesis; D000813:Anilides / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D004487:Edema / Q000139:chemically induced / Q000503:physiopathology; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009539:Nicotinic Acids / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D013488:Suppositories
chemical_list: D000700:Analgesics; D000813:Anilides; D000893:Anti-Inflammatory Agents; D009539:Nicotinic Acids; D013488:Suppositories