Temperature and species differences in susceptibility of kidney cell cultures to mercury toxicity.
The effect of temperature on inorganic mercury toxicity was investigated using kidney tissue culture systems. The relative susceptibility of rabbit (homeothermic) kidney to mercury intoxication was compared to that of Coho salmon (poikilothermic) kidney to mercury intoxication was compared to that of Coho salmon (poikilothermic) kidney over temperature ranges consistent with the habitat of each of the two species. It was demonstrated that susceptibility to mercury toxicity is species dependent; that is, the rabbit kidney cells tolerated higher mercury concentrations in the medium than did the fish-derived cells. Within a given species, susceptibility to mercury toxicity was temperature dependent. Decreasing the temperature increased the toxicity of mercury to cultures of rabbit kidney cells, whereas decreasing temperatures decreased the effect of mercury toxicity on the salmon kidney cells. As a consequence, fish taken from arctic waters are liable to be more toxic when introduced into mammalian food chains. Albumin was shown to act as a protective agent in vitro against inorganic mercury toxicity.
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured / Q000187:drug effects*; D005780:Gelatin / Q000494:pharmacology; D007668:Kidney; D008628:Mercury / Q000633:toxicity*; D011817:Rabbits; D012474:Salmon; D012710:Serum Albumin, Bovine / Q000494:pharmacology; D013045:Species Specificity; D013696:Temperature
D012710:Serum Albumin, Bovine; D005780:Gelatin; D008628:Mercury