Amantadine-resistance as a genetic marker for influenza viruses.
The infection of eggs, cell cultures or mice with a mixture of amantadine-resistant and amantadine-sensitive strains of influenza virus resulted in the transfer of amantadine-resistance or sensitivity between strains. The response of a recombinant virus to amantadine was not related to either of its surface antigens. Resistance to amantadine was transferred as an all-or-none character. It is concluded that amantadine-resistance is a useful genetic marker for influenza viruses.
D000547:Amantadine / Q000494:pharmacology*; D000818:Animals; D002642:Chick Embryo; D004352:Drug Resistance, Microbial; D005796:Genes; D009975:Orthomyxoviridae / Q000187:drug effects* / Q000254:growth & development; D011995:Recombination, Genetic; D014779:Virus Replication / Q000187:drug effects
D000547:Amantadine