The neuromuscular blocking activity of aminodeoxykanamycin as compared with that of other aminoglycoside antibiotics.
Aminodeoxykanamycin (Kaneudomycin) as well as other members of the aminoglycoside antibiotics, has an action at the neuromuscular junction. Kanendomycin was found to be five times less potent than gentamycin, as far as their neuromuscular blocking action on the rat diaphragm is concerned. The neuromuscular blocking action on the rat diaphragm is concerned. The neuromuscular blockade produced by Kanendomycin is not reversed by neostigmine but only by calcium chloride.
D000617:Aminoglycosides / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D002122:Calcium Chloride / Q000494:pharmacology; D005839:Gentamicins / Q000494:pharmacology; D007612:Kanamycin / Q000494:pharmacology; D008297:Male; D009388:Neostigmine / Q000494:pharmacology; D009466:Neuromuscular Blocking Agents; D009469:Neuromuscular Junction / Q000187:drug effects*; D051381:Rats; D013307:Streptomycin / Q000494:pharmacology
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D005839:Gentamicins; D009466:Neuromuscular Blocking Agents; D009388:Neostigmine; D007612:Kanamycin; D002122:Calcium Chloride; D013307:Streptomycin