Immunological studies of human anterior uveitis.
Immunofluorescent studies revealed extracellular deposits of IgG and C3 as well as immunoglobulin containing inflammatory cells in the affected iris of a patient suffering from endogenous acute uveitis. Antibodies to uveal components were detected in the serum of 4 out of a total of 23 endogenous uveitis patients examined. Examination of these 23 sera also revealed antinuclear activity in one, antismooth muscle activity in one, and anti-mitochondrial activity in three. None of the sera showed anti-thyroglobulin activity. Antibodies to uveal components or immune complexes containing 'auto-antibodies' do not appear to be a common source of tissue damage in human endogenous anterior uveitis.
D001323:Autoantibodies / Q000032:analysis; D003176:Complement C3 / Q000032:analysis; D003181:Complement C4; D003165:Complement System Proteins / Q000032:analysis; D005340:Fibrinogen; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007498:Iris / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D014606:Uveitis, Anterior / Q000276:immunology*
D001323:Autoantibodies; D003176:Complement C3; D003181:Complement C4; D007074:Immunoglobulin G; D005340:Fibrinogen; D003165:Complement System Proteins