title: The effect of Schistosoma mansoni infection, and of oxamniquine, a new antischistosomal drug on some vitamins in the livers of hamsters.
abstract: The hepatic levels of thiamine, pantothenic acid and niacin in hamsters infected with S. mansoni were depressed, while the levels of riboflavin and pyridoxine remained unchanged. A single dose of oxamniquine, 10-50 mg/kg, brought the levels of thiamine, pantothenic acid and niacin to values not significantly different from those in non-infected controls, but lowered the concentrations of riboflavin and pyridoxine in infected hamsters.
mesh_terms: D000818:Animals; D050260:Carbohydrate Metabolism; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D008099:Liver / Q000032:analysis* / Q000378:metabolism; D009600:Nitroquinolines / Q000494:pharmacology*; D010073:Oxamniquine / Q000494:pharmacology* / Q000627:therapeutic use; D012550:Schistosoma mansoni; D012552:Schistosomiasis / Q000188:drug therapy / Q000378:metabolism*; D013997:Time Factors; D014803:Vitamin B Complex / Q000032:analysis*
chemical_list: D009600:Nitroquinolines; D010073:Oxamniquine; D014803:Vitamin B Complex