The synthesis of dimethylphosphonoprostaglandin analogs.
The synthesis of prostaglandin analogs incorporating the dimethylphosphono or dimethylphosphonomethyl moiety in place of the carboxylic acid moiety is described. These analogs exhibited only very low levels of smooth muscle activity during biological testing.
D000818:Animals; D009130:Muscle, Smooth / Q000187:drug effects; D011465:Prostaglandins, Synthetic / Q000138:chemical synthesis* / Q000494:pharmacology
D011465:Prostaglandins, Synthetic