title: E1On the effect of 6-methyluracil on mice damaged by 2,4,6-triethylene-imino-1,3,5-triazine or by X-irradiation (author's transl).
abstract: Survival time of mice after i.v. injections of 2,4.6-triethylene-imino-1,3,5-trazine (TEM) or total body-X-irradiation (TBI) was increased by 6-methyluraclil (6-MU) when given in food (200 ppm). Under the same conditions, 6-MU decreased the involution of spleen and thymus (as measured by DNA-content and DNase II activity) under the infuence of TEM and enhanced the regeneration of the spleen after TBI. Elevation of DNase I- and protein content of the kidneys and a (short-dated) increase of incorporation of 14C-phenylalamine into microsomes of liver of 14C-orotic acid into RNA of liver and kidney suggest that the influence of 6-MU is mediated at least partly by a specfically anabolic effect.
mesh_terms: D000818:Animals; D004247:DNA / Q000096:biosynthesis; D003851:Deoxyribonucleases / Q000378:metabolism; D005503:Food Additives; D006133:Growth Substances; D008297:Male; D051379:Mice; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis; D011833:Radiation Injuries, Experimental / Q000378:metabolism; D012038:Regeneration / Q000187:drug effects; D013154:Spleen / Q000378:metabolism; D013950:Thymus Gland / Q000378:metabolism; D014265:Triethylenemelamine / Q000037:antagonists & inhibitors; D014498:Uracil / Q000031:analogs & derivatives* / Q000494:pharmacology; D014965:X-Rays
chemical_list: D005503:Food Additives; D006133:Growth Substances; D014498:Uracil; D012313:RNA; D004247:DNA; D003851:Deoxyribonucleases; D014265:Triethylenemelamine
vernacular_title: Zur Wirkung von 6-Methyluracil auf Mäuse nach Schädigung durch 2,4,6-Triäthylenimino-1,3,5-triazin oder Röntgenbestrahlung