Chemoimmunotherapy of sarcomatoid renal cell carcinoma.
Sarcomatoid renal adenocarcinomas are rare, invariably fatal tumors. There is only one report of treatment of this tumor with chemotherapy. We report a case of an advanced sarcomatoid renal adenocarcinoma treated with chemoimmunotherapy consisting of cyclophosphamide, vincristine, Adriamycin (doxorubicin), DTIC, BCG, and sarcoma viral oncolysate. The patient had an objective response with a marked reduction in the size of the tumor mass. The residual tumor was removed surgically, and the patient remains in complete remission two years after the diagnosis was made.
D000008:Abdominal Neoplasms / Q000628:therapy; D000230:Adenocarcinoma / Q000473:pathology / Q000628:therapy*; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001500:BCG Vaccine / Q000627:therapeutic use*; D002296:Carcinosarcoma / Q000473:pathology / Q000628:therapy*; D003520:Cyclophosphamide / Q000008:administration & dosage; D003606:Dacarbazine / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012509:Sarcoma / Q000276:immunology / Q000382:microbiology; D014412:Tumor Virus Infections / Q000276:immunology; D014750:Vincristine / Q000008:administration & dosage; D014765:Viral Vaccines / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D001500:BCG Vaccine; D014765:Viral Vaccines; D014750:Vincristine; D003606:Dacarbazine; D004317:Doxorubicin; D003520:Cyclophosphamide