The effect of baclofen on alpha-flupenthixol-induced catalepsy in the rat.
1 alpha-Flupenthixol (alpha-FPT; 0.2 mg/kg i.p.) when administered to rats produced catalepsy. 2 Baclofen (10 mg/kg i.p.) given 30 min after alpha-FPT had a biphasic effect on the catalepsy. Initially there was a potentiation of the effect, followed by a significant attenuation of the degree of catalepsy. 3 Possible mechanisms of action are discussed.
D000613:Aminobutyrates / Q000494:pharmacology*; D000818:Animals; D001418:Baclofen / Q000494:pharmacology*; D002375:Catalepsy / Q000139:chemically induced / Q000503:physiopathology*; D004347:Drug Interactions; D005260:Female; D005475:Flupenthixol / Q000494:pharmacology*; D006801:Humans; D051381:Rats; D013892:Thioxanthenes / Q000494:pharmacology*
D000613:Aminobutyrates; D013892:Thioxanthenes; D005475:Flupenthixol; D001418:Baclofen