title: The insensitivity of mushroom nuclear RNA polymerase activity to inhibition by amatoxins.
abstract: Nuclear fractions isolated from Amanita phalloides, Amanita muscaria and Agaricus bisporus were subjected to in vitro RNA synthesis assays in the presence of various concentrations of amatoxins. The mushroom nuclei were highly insensitive to inhibition by amatoxin when compared to assays of nuclear fractions isolated from the Oömycete fungus, Achlya ambisexualis and from rabbit brain.
mesh_terms: D000363:Agaricales / Q000201:enzymology*; D000545:Amanita / Q000201:enzymology; D000546:Amanitins / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000201:enzymology; D002467:Cell Nucleus / Q000201:enzymology; D012321:DNA-Directed RNA Polymerases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D009868:Oomycetes / Q000201:enzymology; D012313:RNA / Q000096:biosynthesis; D011817:Rabbits
chemical_list: D000546:Amanitins; D012313:RNA; D012321:DNA-Directed RNA Polymerases