Rutosides and radiation induced regression of experimental tumours.
The effect of some flavonoids like O-(beta-hydro-xyethyl)-rutoside, alone and in combination with X-rays, was investigated on three transplantable mouse tumours. The growth characteristics of the tumours depending on the sex of the host animal and the application of flavonoids are described. Under the different experimental conditions exployed involving 1500 mice, flavonoids did not alter the radiation effect on the tumours as neither a protective nor a sensitizing effect was observed.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000532:radiotherapy; D002392:Catechin / Q000494:pharmacology; D005260:Female; D006896:Hydroxyethylrutoside / Q000494:pharmacology*; D007460:Iodoacetamide / Q000494:pharmacology; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000532:radiotherapy*; D011837:Radiation-Protective Agents; D011838:Radiation-Sensitizing Agents; D012431:Rutin / Q000031:analogs & derivatives*; D012510:Sarcoma 180 / Q000532:radiotherapy; D014594:Uterine Neoplasms / Q000532:radiotherapy
D006896:Hydroxyethylrutoside; D011837:Radiation-Protective Agents; D011838:Radiation-Sensitizing Agents; D012431:Rutin; D002392:Catechin; D007460:Iodoacetamide