[Behaviour of intestinal goblet cells following application of oxidated water soluble terpenes. A pilot study (author's transl)].
1 and 3 h after i.p. application of Ozothin, an oxidation product of Bordeaux terpin oil, in rats there is a significant increase in goblet cells both totally and in the tightly filled ones (respectively in the villi of the small intestine). Double i.v. injection of therapeutic doses of Ozothin (first 14 h and booster 2 h preoperatively) induces a significant decrease in the number of the tightly filled goblet cells. These contradictory results may partly be explained as an initially timed ischesis of mucigenous glands by Ozothin. Statistically significant differences among the different series of tests could be found only in the epithelium of the villi. In the crypts there were similar results lacking statistical significance.
D000293:Adolescent; D000328:Adult; D000818:Animals; D002452:Cell Count; D005260:Female; D006801:Humans; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007413:Intestinal Mucosa / Q000166:cytology / Q000187:drug effects*; D007421:Intestine, Small / Q000166:cytology / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009077:Mucins / Q000378:metabolism; D010865:Pilot Projects; D051381:Rats; D013729:Terpenes / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
D009077:Mucins; D013729:Terpenes
Verhalten intestinaler Becherzellen nach Applikation oxydierter, teilweise wasserlöslicher Terpene. Eine Pilot-Studie