title: [Neurotropic action of probon compared to amidopyrine].
abstract: In comparing the neurotropic action of probon and amidopyrine it became evident that both analgesics inhibit the behavioral reactions of rats in "open field" tests, fail to produce any protective action with respect to the reflex reaction of the heart in response to pain stimulation and attenuate such an effect of seduxen. By lengthening the hexobarbital-induced sleep probon and amidopyrine change the EEG nature typical of the effect produced by barbiturates. The difference between the study analgesics is rather a quantitative one, viz. in many rests probon is more potent and its action manifestes itself in a wider range of dosages.
mesh_terms: D000632:Aminopyrine / Q000494:pharmacology* / Q000627:therapeutic use; D000700:Analgesics / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D001921:Brain / Q000187:drug effects; D003975:Diazepam / Q000037:antagonists & inhibitors / Q000494:pharmacology; D004569:Electroencephalography; D005106:Exploratory Behavior / Q000187:drug effects; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009949:Orientation / Q000187:drug effects; D010146:Pain / Q000188:drug therapy; D011744:Pyrimidinones / Q000494:pharmacology* / Q000627:therapeutic use; D011817:Rabbits; D051381:Rats
chemical_list: D000700:Analgesics; D011744:Pyrimidinones; D000632:Aminopyrine; D003975:Diazepam
vernacular_title: Neĭrotropnoe deĭstvie probona v sravnenii s amidopirinom.