[The action of products of the formaldehyde reaction with different amines on nucleic acids and their components].
The kinetics and equilibrium of the reaction between nucleic acids components and the products of formaldehyde interaction with ethanolamine and different amino acids has been studied. These parameters were found to be similar for all the products used. The destabilization of the N-glycosidic bond in deoxyadenosine caused by formaldehyde derivatives of different amines was studied. The rate of the cleavage of the N-glycosidic bond under the action of formaldehyde derivatives of glycine and ethanolamine was found to be 10 times greater than that under the action of formaldehyde derivatives of other amines. It is shown that DNA preparations with different content of adenine can be obtained by adding the product of formaldehyde reaction with glycine to DNA.
D000596:Amino Acids; D055598:Chemical Phenomena; D002621:Chemistry; D004247:DNA; D004983:Ethanolamines; D005557:Formaldehyde; D005998:Glycine; D011687:Purines; D011743:Pyrimidines
D000596:Amino Acids; D004983:Ethanolamines; D011687:Purines; D011743:Pyrimidines; D005557:Formaldehyde; D004247:DNA; D005998:Glycine
Deĭstvie produktov reaktsii formal'degida s razlichnymi aminami na nukleinovye kisloty i ikh komponenty.