The origin of IgA-containing cells in intestinal lymph of sheep.
The origin of IgA-containing cells in sheep intestinal lymph was determined by antigenically stimulating a mesenteric lymph node and by studying afferent intestinal lymph. Since antigenic stimulation of the node resulted almost exclusively in the appearance of IgG1 antibody-containing cells, it was proposed that IgA-containing cells are normally produced either in the Peyer's patches or lamina propria of the intestine. These conclusions were supported by studying lymph obtained by cannulation of a lymphatic duct afferent to the mesenteric lymph nodes. Study of the cells in afferent lymph revealed the presence of a significant population of IgA-containing blast cells. This was convincing evidence that the IgA-containing cells normally found in intestinal lymph originate from sites in the intestine.
D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology; D002452:Cell Count; D007082:Ileum / Q000166:cytology; D007070:Immunoglobulin A / Q000032:analysis*; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008196:Lymph / Q000166:cytology*; D008198:Lymph Nodes / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology*; D008643:Mesentery; D010581:Peyer's Patches / Q000166:cytology; D012756:Sheep / Q000276:immunology*; D013745:Tetanus Toxoid
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D013745:Tetanus Toxoid