Antagonism of non-steroidal anti-inflammatory drugs and narcotic analgesics against ethacrynic acid induced writhing.
Thiol-group reactive agents [alloxan, N-ethyimaleimide (NEM), ethacrynic acid, p-chlormercuribenzoate (PCMB)] were shown to induce a writhing syndrome in mice and rats when injected i.p. in appropriate dosage. Non-steroidal anti-inflammatory agents, narcotic analgesics and also psychotropic drugs inhibit the syndrome elicited in rats by ethacrynic acid. Rats pretreated with cysteine i.p. show a greatly reduced nociceptive response to ethacrynic acid or alloxan.
D000700:Analgesics / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001095:Arachidonic Acids; D003545:Cysteine / Q000008:administration & dosage; D004976:Ethacrynic Acid / Q000037:antagonists & inhibitors*; D008297:Male; D051379:Mice; D009292:Narcotic Antagonists / Q000494:pharmacology; D013035:Spasm / Q000139:chemically induced* / Q000188:drug therapy
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D001095:Arachidonic Acids; D009292:Narcotic Antagonists; D003545:Cysteine; D004976:Ethacrynic Acid