Derivatives of 1,2,3,3-tetramethyl-2-azabicyclo[2.2.2]octan-5-endo-ol with antiarrhythmic and other activities. I.
A synthesis of esters from 1,2,3,3-tetramethyl-2-azabicyclo[2.2.2]octan-5-endo-ol lithium slat and acyl chlorides is described. A number of these compounds showed strong antiarrhythmic, local anesthetic and hypotensive activities.
D000777:Anesthetics / Q000138:chemical synthesis*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D001392:Azocines / Q000138:chemical synthesis* / Q000627:therapeutic use; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis* / Q000627:therapeutic use; D001952:Bridged-Ring Compounds / Q000138:chemical synthesis*; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects; D006973:Hypertension / Q000188:drug therapy; D051379:Mice; D051381:Rats
D000777:Anesthetics; D000889:Anti-Arrhythmia Agents; D001392:Azocines; D001643:Bridged Bicyclo Compounds; D001952:Bridged-Ring Compounds