Prenatal diagnosis of a de novo Y/22 translocation.
Prenatal chromosomal analysis was performed at 17 weeks' gestation because of the previous birth of a girl with trisomy 13. A seemingly balanced de novo Y/22 translocation was diagnosed. Translocations involving the Y chromosome are rare and no similar translocation, detected pre- or postnatally, could be found in published reports. The counselling problems are discussed. The pregnancy ended at term with the birth of a phenotypically normal boy. After birth, the prenatal diagnosis was confirmed and the H-Y antigen expression was determined.
D000649:Amniocentesis; D002871:Chromosome Banding; D005260:Female; D005817:Genetic Counseling; D006182:H-Y Antigen; D006801:Humans; D007621:Karyotyping; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D011247:Pregnancy; D012730:Sex Chromosomes; D014178:Translocation, Genetic; D014998:Y Chromosome
D006182:H-Y Antigen