Immunokinetics of a single dose of levamisole.
Ten patients with classical or definite rheumatoid arthritis and a low number of E-rosette forming lymphocytes were given single doses of 50, 100 and 150 mg of levamisole. Levamisole produced a dose-related sustained increase in E-rosette forming cells. A single dose of 150 mg restored the number of E-rosette forming cells to normal within 24 hours and this effect lasted 6 to 7 days. These immunokinetic data provide a rational basis for the once-a-week administration of levamisole.
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000276:immunology; D005260:Female; D006801:Humans; D007109:Immunity / Q000187:drug effects*; D007700:Kinetics; D007978:Levamisole / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D012397:Rosette Formation
D007978:Levamisole