Changes in the mouse thymus observed during puberty.
The changes in the female mouse thymuses during puberty were investigated. During this period the lymphatic cell number in the thymus and its proliferative activity were found to decrease while the mitogen reactivity to PHA to increase. These changes cannot be observed in females ovariectomized before puberty. The role of ovarian hormones in the observed phenomenon is discussed.
D000818:Animals; D002369:Castration; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology; D004247:DNA / Q000096:biosynthesis; D004971:Estrus; D005260:Female; D037102:Lectins / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D011247:Pregnancy; D012741:Sexual Maturation; D013936:Thymidine / Q000378:metabolism; D013950:Thymus Gland / Q000187:drug effects / Q000502:physiology*
D037102:Lectins; D003208:Concanavalin A; D004247:DNA; D013936:Thymidine