24 hour profile of 18-hydroxy-11-deoxycorticosterone in normal supine man: relationship with cortisol and aldosterone.
Daily profiles of plasma 18-hydroxy-11-deoxycorticosterone (18-OH-DOC) were studied in four normal supine men on a normal sodium intake. Blood was taken every hour from 01.00 to 24.00 hours. Plasma cortisol (F) and aldosterone (A) were determined hourly for comparative studies. 18-OH-DOC fluctuated considerably during the 24 h period of investigation, the highest values being found during the early morning hours in synchrony with F. The episodic secretions of 18-OH-DOC were also significantly correlated with those of A, which in turn paralleled those of F. We conclude that ACTH, plays a definite role in the regulation of 18-OH-DOC in normal supine men on a normal sodium diet.
D015070:18-Hydroxydesoxycorticosterone / Q000097:blood*; D000328:Adult; D000450:Aldosterone / Q000097:blood*; D002940:Circadian Rhythm; D003900:Desoxycorticosterone / Q000031:analogs & derivatives*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D011187:Posture
D015070:18-Hydroxydesoxycorticosterone; D003900:Desoxycorticosterone; D000450:Aldosterone; D006854:Hydrocortisone