title: Milk fat globule membranes devoid of intramembranous particles.
abstract: When isolated milk fat globule membranes from bovine, human, and murine (rat) milk were examined by freeze-fracturing most of the membrane faces were devoid of membrane-intercalated particles whereas a minor portion showed relatively few particles, either in clusters or in apparent random distribution. A reduced particle density was also noted in membranes of intra-alveolar milk fat globules of cows and rats, in contrast to high particle densities in the apical plasma membrane of lactating epithelial cells. The observations suggest that certain membrane constituents recognized as intramembranous particles either are displaced from the region of the apical surface of the mammary epithelial cell which is involved in milk fat globule budding or are dislocated and rearranged during the budding process.
mesh_terms: D000818:Animals; D002417:Cattle; D002462:Cell Membrane / Q000648:ultrastructure; D004848:Epithelium / Q000648:ultrastructure; D005260:Female; D005614:Freeze Fracturing; D006801:Humans; D007774:Lactation; D008055:Lipids; D008321:Mammary Glands, Animal / Q000648:ultrastructure; D008892:Milk / Q000648:ultrastructure*; D008895:Milk, Human / Q000648:ultrastructure*; D011247:Pregnancy; D051381:Rats
chemical_list: D008055:Lipids