[Rapid change in the dynamics of antibody-forming cells under the influence of a single injection of various anthracyclines].
The dynamics of the titers and number of the antibody forming cells was studied within 26 hours after a single injection of anthracycline to immunized animals at various phases of the immune response. The specificity of the "rapid" effect of anthracyclines suggests that the low differentiated precursors of the antibody forming cells are the main target for the rubomycin effect and the immune competent cells in the state of multiplication and differentiation under the effect of the antigen are the main target for the carminomycin effect. The study was performed with noninbred mice immunized with sheep red cells.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000276:immunology*; D000921:Antibody-Producing Cells / Q000187:drug effects*; D002360:Carubicin / Q000276:immunology; D002452:Cell Count; D003630:Daunorubicin / Q000276:immunology; D006027:Glycosides / Q000008:administration & dosage / Q000276:immunology; D006388:Hemagglutinins / Q000032:analysis; D007114:Immunization; D007165:Immunosuppression Therapy; D066298:In Vitro Techniques; D007275:Injections, Intravenous; D008297:Male; D051379:Mice; D009281:Naphthalenes / Q000008:administration & dosage / Q000276:immunology*; D013997:Time Factors
D000903:Antibiotics, Antineoplastic; D006027:Glycosides; D006388:Hemagglutinins; D009281:Naphthalenes; D002360:Carubicin; D003630:Daunorubicin
Bystroe izmenenie dinamiki antiteloobrazuiushchikh kletok pod vliianiem odnokratnoĭ in''ektsii razlichnykh antratsiklinov.