[The influence of the broncholytic reproterol in persons with bradycardic arrhythmia upon impulse and conduction as well as irritability of the human ventricle (author's transl)].
The new  broncholytic 7-(3-[2-(3,5-dihydroxyphenyl)-2-hydroxy-ethylamino]-propyl)-theophylline (reproterol, Bronchospasmin), a beta-phenylethyl-aminoalkyl-xanthine, was investiggated in two doses (60 and 90 mug i.v.) in patients who suffered from bradycardic arrhythmia. The influence on the primary and tertiary impulses and conduction in 36 cases and on the irritability of the human ventricle in 8 cases was tested. Reproterol led to a tolerable increase in the atrial and ventricular rate as well as to a desirable acceleration of the AV conduction. Irritability was significantly increased to a lesser degree than by the administration of orciprenaline and oxyfedrine. Except for a few, but not threatening, extrasystoles, two cases with bigeminal rhythms and some cases with a thermacogenesis, no undersible side effects were noted following injection.
D001919:Bradycardia / Q000503:physiopathology*; D001993:Bronchodilator Agents / Q000009:adverse effects*; D004558:Electric Stimulation; D004562:Electrocardiography; D006329:Heart Conduction System / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D010627:Phenethylamines / Q000009:adverse effects*; D014970:Xanthines / Q000009:adverse effects*
D001993:Bronchodilator Agents; D010627:Phenethylamines; D014970:Xanthines
Die Beeinflussung der Reizbildung und Reizleitung sowie der Irritabilität des menschlichen Ventrikels durch das Broncholytikum Reproterol bei Personen mit bradykarden Rhythmusstörungen