title: Gene mutation and sister chromatid exchange in Chinese hamster cells.
abstract: The mutation in hypoxanthine phosphoribosyl transferase gene and the induction of sister chromatid exchange (SCE) were comparatively studied treating Chinese hamster ovary cells with the mutagens ethylmethanesulphonate. N-methyl-N'-nitro-N-nitrosoguanidine, Mitomycin C and X-ray. All the agents exerted strong mutagenic effects and showed a dose-dependent relationship for the induction of SCEs.
mesh_terms: D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D006224:Cricetinae; D003434:Crossing Over, Genetic; D005020:Ethyl Methanesulfonate / Q000494:pharmacology; D005260:Female; D005796:Genes; D007041:Hypoxanthine Phosphoribosyltransferase / Q000235:genetics*; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology; D008937:Mitomycins / Q000494:pharmacology; D009154:Mutation; D010053:Ovary; D012854:Sister Chromatid Exchange; D014965:X-Rays
chemical_list: D008937:Mitomycins; D008769:Methylnitronitrosoguanidine; D005020:Ethyl Methanesulfonate; D007041:Hypoxanthine Phosphoribosyltransferase