Small lymphocyte production and lymphoid cell proliferation in mouse bone marrow.
In mice given 3H-thymidine systemically during temporary circulatory occlusion of one hind limb, comparison of the labeling of rapidly-renewing small lymphocytes in the tibial marrows demonstrated that these cells were locally produced. Labeling by 3H-thymidine infusion revealed that many marrow large lymphoid cells, presumptive small lymphocyte progenitors, had a marked proliferative activity and rapid turnover which varied according to cell size, was maximal in young mice and declined with increasing age.
D000375:Aging; D000818:Animals; D001853:Bone Marrow; D001854:Bone Marrow Cells; D002452:Cell Count; D008214:Lymphocytes; D051379:Mice