title: [Concentrations in serum and tonsils after infection of azidocillin (author's transl)].
abstract: Prior to tonsillectomy 57 selected patients were given 1 g azidocillin i.v. in the form of a 10% aqueous solution. Serum samples were drawn at different times after the injection and both the serum and the tonsils were examined for azidocillin activity. The results of examination of 133 serum samples and 111 tonsils were evaluated, in addition to 74 paired values for tonsils and serum. Serum levels attained a maximum of 230 microng/ml and remained within measurable range for at least six hours. Tonsil levels  reached a maximum of 17 microng/g and after three hours began to drop below measurable range. The quotient for distribution between tonsils and serum rose during the first hour to 20-25% (average approx. 10%) and was about 3-6% three to four hours after injection.
mesh_terms: D000328:Adult; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D008297:Male; D014066:Palatine Tonsil / Q000032:analysis / Q000378:metabolism*; D010400:Penicillin G / Q000031:analogs & derivatives* / Q000032:analysis / Q000097:blood / Q000378:metabolism*; D010406:Penicillins / Q000378:metabolism*
chemical_list: D010406:Penicillins; D010400:Penicillin G
vernacular_title: Serum- und Tonsillenkonzentrationen nach Injektion von Azidocillin