Toxicologic and teratologic studies of oxibendazole in ruminants and laboratory animals.
Acute toxicity of oxibendazole was assessed with single oral doses given to mice (4 to 32 g/kg of body weight), sheep (230 to 600 mg/kg), and cattle (600 mg/kg); there were no ill effects. Subacute toxicity did not occur with multiple doses given 5 days to cattle (30 to 75 mg/kg/day) and to sheep (10 to 50 mg/kg/day). Chronic effects did not occur with daily doses of 3 to 30 mg/kg given 98 days to rats and dogs. Teratogenicity of the compound was studied in mice, rats, and sheep medicated at a dose level of 30 mg of oxibendazole/kg and in cattle given 75 mg/kg on selected dates during pregnancy. Microscopically, rodent fetuses seemed normal, and on gross physical examination, lambs and calves were free of malformations and ossification variations.
D000014:Abnormalities, Drug-Induced / Q000662:veterinary; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001562:Benzimidazoles / Q000633:toxicity*; D002219:Carbamates / Q000633:toxicity*; D002417:Cattle; D002418:Cattle Diseases / Q000139:chemically induced*; D002802:Cholinesterases / Q000097:blood; D004285:Dogs; D005260:Female; D008297:Male; D051379:Mice; D010012:Osteogenesis; D011247:Pregnancy; D051381:Rats; D012756:Sheep; D012757:Sheep Diseases / Q000139:chemically induced*; D013723:Teratogens
D001562:Benzimidazoles; D002219:Carbamates; D013723:Teratogens; C011321:oxibendazole; D001219:Aspartate Aminotransferases; D002802:Cholinesterases