Hepatic lesions in asymptomatic children of leprosy patients.
Forty-two asymptomatic children of leprosy patients were studied for possible hepatic lesions. Hepatic lesions were observed in 47% while acid-fast bacilli in the liver were found in 9.5%. The most frequent lesions encountered included granuloma in 9.5%, focal areas of necrosis in 14%, portal triaditis in 17%, and Kupffer cell hyperplasia in 33%. Occasionally more than one lesion was observed in a biopsy. No correlation with the occurrence of the various hepatic lesions could be made with a history of BCG vaccination or results of skin tests done with tuberculin and lepromin.
D000293:Adolescent; D002648:Child; D006801:Humans; D007728:Kupffer Cells / Q000473:pathology; D007918:Leprosy / Q000473:pathology*; D008099:Liver / Q000473:pathology*; D008297:Male; D009336:Necrosis