[Comparative effects of different inhibitors of phenylalanine hydroxylase and dihydropteridine reductase. In vivo and in vitro study in rats].
The effects of inhibitors of phenylalanine hydroxylase and dihydropteridine reductase have been tested in vivo and in vitro to induce classical phenylketonuria and the variant due to dihydropteridine reductase deficiency. In addition two inhibitors of intestinal absorption of phenulalanine were investigated. Blood, urine, and hepatic parameters have been measured and are discussed.
D000818:Animals; D004093:Dihydropteridine Reductase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D004195:Disease Models, Animal; D006801:Humans; D008099:Liver / Q000201:enzymology; D009247:NADH, NADPH Oxidoreductases / Q000037:antagonists & inhibitors*; D010649:Phenylalanine / Q000097:blood; D010651:Phenylalanine Hydroxylase / Q000037:antagonists & inhibitors* / Q000172:deficiency / Q000378:metabolism; D010661:Phenylketonurias / Q000097:blood / Q000139:chemically induced*; D051381:Rats; D014443:Tyrosine / Q000097:blood
D014443:Tyrosine; D010649:Phenylalanine; D010651:Phenylalanine Hydroxylase; D004093:Dihydropteridine Reductase; D009247:NADH, NADPH Oxidoreductases
Comparaison des effets de différents inhibiteurs vis-à-vis de la phénylalanine hydroxylase et de la dihydroptéridine réductase. Etude in vitro et in vivo chez le rat.