[Comparison of the action of carminomycin and rubomycin on the dynamics of the primary and secondary immune responses].
The effect of rubomycin and carminomycin on the dynamics of the primary and secondary immune response and formation of the immunologic memory to sheep red cells in mice was studied. Differences in the character of the antibiotics effect indicative of the higher selective action of carminomycin on multiplying cells, precursors of the antibody-forming plasmids, were found. Theoretically interesting discrepancies in the effect of the antibiotics on the content of the antibodies in the serum and the antibody-producing cells in the spleen were shown. It was demonstrated that carminomycin had no effect on formation of the immunologic memory inspite of a noticeable decrease in the total number of the spleen nuclear cells and the number of the antibody-forming cells at the moment of immunization under the effect of the antibiotic.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000276:immunology*; D000917:Antibody Formation / Q000187:drug effects*; D000921:Antibody-Producing Cells / Q000187:drug effects; D002360:Carubicin / Q000276:immunology*; D003630:Daunorubicin / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D004912:Erythrocytes / Q000276:immunology; D007111:Immunity, Cellular / Q000187:drug effects; D007156:Immunologic Memory / Q000187:drug effects*; D008297:Male; D051379:Mice; D012756:Sheep; D013997:Time Factors
D000903:Antibiotics, Antineoplastic; D002360:Carubicin; D003630:Daunorubicin
Sravnenie deĭstviia karminomitsina i rubomitsina na dinamiku pervichnogo i vtorichnogo immunogo otveta.