title: Functional genetic damages and their possible role in the aging of eukaryote cells.
abstract: As a result of investigations of the functional acitivty of eukaryote cells damaged by ionizing radiation and alkylating mutagens under conditions of extreme loading, the authors have suggested that natural aging and aging accelerated by mutagens are based on a process of accumulation of functional genetic damages. The molecular nature of these damages differs from the mutational changes and repairable damages of DNA.
mesh_terms: D000375:Aging; D000818:Animals; D001388:Aziridines / Q000494:pharmacology; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000528:radiation effects*; D008115:Liver Regeneration / Q000187:drug effects / Q000528:radiation effects; D008938:Mitosis / Q000187:drug effects / Q000528:radiation effects; D009153:Mutagens / Q000494:pharmacology*; D009154:Mutation / Q000528:radiation effects*; D010634:Phenobarbital / Q000494:pharmacology; D010879:Piperazines / Q000494:pharmacology; D014176:Protein Biosynthesis / Q000187:drug effects; D051381:Rats; D014158:Transcription, Genetic / Q000187:drug effects
chemical_list: D001388:Aziridines; D009153:Mutagens; D010879:Piperazines; D003577:Cytochrome P-450 Enzyme System; C007526:dipin; D010634:Phenobarbital