[Intraportal and intravenous administration of fat emulsions. Comparison of liver morphology in animal experiments].
In short infusion series run over 5 days, a fat emulsion on the basis of soya oil with egg lecithin used as emulsifier has been infused to rabbits by the intravenous and intraportal routes in a dosage of 2 and 4 g/kg bodyweight/day. By a light-microscopic analysis of the liver morphology after one and three weeks, mainly a fatty degeneration of the Kupffer's cells of the liver was found. It was considerably less conspicuous after endo-portal supply than after peripheric-intravenous supply--findings which became more obvious with the higher dose.
D000818:Animals; D004041:Dietary Fats / Q000008:administration & dosage*; D004655:Emulsions; D005234:Fatty Liver / Q000209:etiology; D005260:Female; D007275:Injections, Intravenous; D007728:Kupffer Cells / Q000473:pathology; D008297:Male; D011169:Portal Vein; D011817:Rabbits
D004041:Dietary Fats; D004655:Emulsions
Intraportale und intravenöse Zufuhr von Fettemulsionen--Ein Vergleich der Lebermorphologie im Tierversuch.