title: [Folic acid and pregnancy, a real problem?].
abstract: The efficacy of prophylactic treatment with ferrous sulfate (80 mg Fe++) and the combination of ferrous sulfate with folic acid (80 mg Fe++ and 350 microgram folic acid) were studied in a double blind trial in the 20th, and again in the 30th and 36th week of pregnancy (29 patients). At the beginning of the treatment (20th week) 29% of the patients showed a pathologically reduced serum folic acid level. Combined therapy has a favorable effect on the folic acid levels in the serum and red blood cells; this was confirmed statistically. At the end of pregnancy, 69% of the patients of the control group (ferrous sulfate) showed a pathologically reduced serum level and 23% a subnormal level in erythrocytes. These results unquestionably justify the prophylactic prescription of folic acid during pregnancy.
mesh_terms: D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D005296:Ferrous Compounds / Q000008:administration & dosage*; D005492:Folic Acid / Q000008:administration & dosage* / Q000097:blood; D005494:Folic Acid Deficiency / Q000517:prevention & control*; D006801:Humans; D007501:Iron / Q000008:administration & dosage* / Q000097:blood; D011247:Pregnancy; D011248:Pregnancy Complications / Q000517:prevention & control*; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third
chemical_list: D005296:Ferrous Compounds; D005492:Folic Acid; D007501:Iron
vernacular_title: Acide folique et gravidité, problème réel?