Porcine mastitis-metritis-agalactia (MMA) syndrome: mammary gland responsiveness to oxytocin given to healthy sows during lactation.
Mammary gland responsiveness to exogenous oxytocin during lactation was assessed by measuring changes in intramammary pressure of healthy sows given (IM injection) synthetic oxytocin (40 U). Response to oxytocin was measured once a week for the first 8 weeks of lactation. Recordings of pressure changes were expressed as mean area (cm2) under the trace at each 10-minute interval over 30 minutes after oxytocin had been given. During the 2nd week of lactation, there was a 55.3% increase (P less than 0.05) in responsiveness to oxytocin (25.1 +/- 4.2 cm2/10 minutes) as compared with the 1st week (13.9 +/- 2.2 cm2/10 minutes). Responsiveness decreased, however, from the 2nd to the 8th week. Since the incidence of mastitis-metritis-agalactia in sows is particularly high during the 1st week of lactation, low responsiveness of the mammary gland to oxytocin may be a contributing factor.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004716:Endometritis / Q000662:veterinary; D005260:Female; D007774:Lactation / Q000187:drug effects; D007775:Lactation Disorders / Q000662:veterinary; D008321:Mammary Glands, Animal / Q000187:drug effects*; D008413:Mastitis / Q000662:veterinary; D010121:Oxytocin / Q000008:administration & dosage / Q000494:pharmacology*; D011247:Pregnancy; D013552:Swine / Q000502:physiology*; D013553:Swine Diseases / Q000503:physiopathology; D013577:Syndrome / Q000662:veterinary
D010121:Oxytocin