Interactions of immune complexes and platelets in rabbits immunized with hapten-carrier conjugates.
The thrombopenic effects of immune complexes were studied in 32 rabbits, immunized actively with aspirin. The test animals were exposed to hapten-protein conjugates with a hapten density ranging from 0.6 to 38, and to pure hapten. The resulting thrombopenia and leucopenia correlated closely with the presence of immune complexes in the serum as detected by the platelet aggregation sedimentation pattern test (P1.A.). This platelet-aggregation activity sedimented mainly in the 19S fraction. The effects induced by polyvalent antigens where dose-dependent and could be modified by a prior injection of aspirin. Expectedly, monovalent antigens were only marginally effective.
D000818:Animals; D000917:Antibody Formation; D000936:Antigen-Antibody Complex; D000941:Antigens; D001241:Aspirin / Q000276:immunology; D001792:Blood Platelets / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D006241:Haptens; D007970:Leukopenia / Q000209:etiology; D010974:Platelet Aggregation; D011817:Rabbits; D013921:Thrombocytopenia / Q000209:etiology
D000936:Antigen-Antibody Complex; D000941:Antigens; D006241:Haptens; D001241:Aspirin