Long term effect of teflutixol on apomorphine-induced stereotypy and vomiting in dogs.
Dose--response relationships to apomorphine-induced vomiting and stereotyped running behaviour have been determined in dogs before, and up to 24 and 28 days respectively, after daily oral treatment with 2.5 mg/kg of teflutixol or 12 days. The ED50 values for apomorphine-induced vomiting after teflutixol were not different from those obtained before treatment. Stereotyped running behaviour of increasing intensity was seen 4--12 days after teflutixol treatment. The intensity then declined and returned to normal. The results suggest that the nigro-neostriatal dopamine system in dogs became hypersensitive after prolonged teflutixol treatment, while the dopamine receptors of the emetic chemotrigger zone did not.
D000818:Animals; D001058:Apomorphine / Q000037:antagonists & inhibitors*; D001519:Behavior / Q000187:drug effects*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D013239:Stereotyped Behavior / Q000187:drug effects*; D013892:Thioxanthenes / Q000494:pharmacology*; D014839:Vomiting / Q000139:chemically induced
D013892:Thioxanthenes; D001058:Apomorphine