Correlation of cell kinetic findings with morphology of non-Hodgkin's malignant lymphomas.
Kinetic studies were carried out on 6 benign and 37 malignant lymph nodes from patients with non-Hodgkin's malignant lymphomas (ML). The labeling index, DNA content, and cell distribution through the cell cycle were analyzed in the ML, which were classified according to the Kiel classification. Approximately 90% of the ML studied showed a clear diploidy; the only cases of polyploidy were limited to some centroblastic-centrocytic ML with more than 30% malignant centroblasts and to be single centroblastic ML. The labeling indexes ranged from 0.05 to 33%. No correlation was found between the proliferative rate and the degree of ploidy, while a grading of labeling index was found in relation to the three main DNA distribution patterns observed (i.e., G1 peak, S accumulation, and bimodal distribution through the cell cycle). From a kinetic point of view, the most heterogeneous groups were the lymphoplasmacytoid (subtype polymorphous) and centroblastic-centrocytic ML, where the degree of proliferation increased as the mixture of cell type (relative to the former group) and the malignant centroblastic component (relative to the latter group) increased.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002455:Cell Division; D004273:DNA, Neoplasm / Q000032:analysis / Q000096:biosynthesis; D004171:Diploidy; D005260:Female; D006801:Humans; D007700:Kinetics; D008198:Lymph Nodes / Q000473:pathology; D008223:Lymphoma / Q000032:analysis / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology; D008297:Male; D008875:Middle Aged
D004273:DNA, Neoplasm