title: A gas-liquid chromatographic method for the determination of butriptyline in serum.
abstract: 1. A gas-liquid chromatographic (GC) method for the analysis of butriptyline in serum has been development. Quantitation is based on the peak height ratio between butriptyline and promazine used as internal standard. A triple partition provides a "clean" extract. A detection limit of 10 ng/ml is achieved. 2. The usefulness of the method has been demonstrated in bioavailability studies in dogs.
mesh_terms: D000818:Animals; D002849:Chromatography, Gas / Q000379:methods; D003986:Dibenzocycloheptenes / Q000097:blood*; D004285:Dogs; D004355:Drug Stability; D006801:Humans; D008832:Microchemistry; D012044:Regression Analysis
chemical_list: D003986:Dibenzocycloheptenes