[Findings following antidote therapy in rats intoxicated with phosphoracetic acid. / Histochemical and biochemical lipid demonstration in liver and kidneys (author's transl)].
The fatty degeneration of the liver and kidney of Sprague-Dawley rats was observed by histochemical and biochemical means after intoxication with LD50 and 8 X LD50 O,O-diethyl-O-p-nitro-phenylphosphate (paraoxon). The degree of fatty degeneration in these organs was demonstrated alternately after antidote-treatment with bis(pyridinium-4-aldoxim-1-methyl) ether (Toxogonin) and after injection of a combination of Toxogonin, atropine and a protein-free extract from calf blood containing low-molecular substances (Actihaemyl, Solcoseryl). Under the influence of Actihaemyl the degree of fatty degeneration induced by the toxin was, in respect to both triglycerides and phospholipids, near control levels. The mode of action of Actihaemyl is discussed with regard to the activation of fatty acids.
D000183:Actihaemyl / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000931:Antidotes / Q000627:therapeutic use*; D005234:Fatty Liver / Q000139:chemically induced / Q000188:drug therapy; D005260:Female; D007668:Kidney / Q000378:metabolism*; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism*; D010261:Paraoxon / Q000506:poisoning*; D051381:Rats
D000931:Antidotes; D000183:Actihaemyl; D010261:Paraoxon
Befunde an phosphorsäureester-vergifteten Ratten nach Antidottherapie. I. Histo- und biochemische Fettdarstellung in Leber und Niere.