The effect of the nitroimidazole drug dimetridazole on microaerophilic campylobacters.
Dimetridazole, a nitroimidazole drug reported to act only on obligately anaerobic micro-organisms, is widely used for the prevention and treatment of swine dysentery. Forty-four strains of the microaerophilic bacterium Campylobacter coli isolated from either healthy or diseased pigs, and a strain of Campylobacter fetus, were all sensitive to dimetridazole. The sensitivities (minimal inhibitory concentration less than 10 microng per ml) were similar to those of anaerobic bacteria. Dimetridazole inhibited growth of campylobacters in a shaken culture in air, but did not inhibit uptake of oxygen. Inhibition of growth appeared to result from an inhibition of nucleic-acid synthesis and does not seem to depend upon interference with electron transport in the catabolism of pyruvate.
D000818:Animals; D002167:Campylobacter / Q000187:drug effects*; D002168:Campylobacter fetus / Q000302:isolation & purification / Q000378:metabolism; D004247:DNA / Q000096:biosynthesis; D004131:Dimetridazole / Q000494:pharmacology*; D004403:Dysentery / Q000662:veterinary; D004579:Electron Transport / Q000187:drug effects; D005243:Feces / Q000382:microbiology; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism; D009593:Nitroimidazoles / Q000494:pharmacology*; D010100:Oxygen / Q000378:metabolism; D011773:Pyruvates / Q000378:metabolism; D012313:RNA / Q000096:biosynthesis; D013552:Swine; D013553:Swine Diseases / Q000382:microbiology
D009593:Nitroimidazoles; D011773:Pyruvates; D012313:RNA; D004247:DNA; D009247:NADH, NADPH Oxidoreductases; D004131:Dimetridazole; D010100:Oxygen