Dopamine-agonist drugs and cerebral electrical activity in the rabbit.
The eeg changes induced by acute administration in rabbits of dopamine-agonist drugs (bromocriptine, apomorphine, piribedil) were studied. We examined the spontaneous electric activity of cortex and deep structures, the electric excitability thresholds and the action of these drugs in "cerveau isolé" rabbit. Eeg findings were correlated with behavioural reactions. The modes of action and the probable double point of attack of the drugs at the CNS are discussed.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D001971:Bromocriptine / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000187:drug effects; D005071:Evoked Potentials / Q000187:drug effects; D006801:Humans; D007031:Hypothalamus / Q000187:drug effects; D010879:Piperazines / Q000494:pharmacology*; D010891:Piribedil / Q000494:pharmacology*; D011817:Rabbits; D013239:Stereotyped Behavior / Q000187:drug effects; D013788:Thalamus / Q000187:drug effects
D010879:Piperazines; D001971:Bromocriptine; D010891:Piribedil; D001058:Apomorphine