title: [Effect of phosphemide and forpurine on antibody formation].
abstract: Tests conducted on mice of the CBA line immunized with sheep erythrocytes have brought evidence that, when introduced to the animals 24 and 48 hours after immunization, phosphemide appreciably reduces the number of cells producing the IgM- and IgG-anibodies. The maximum immunodepressive effect of phopurine was observed when this was introduced simultaneously with the antigen, and also 24 and 48 hours following immunization. Both compounds produced a change in the mass of the immuno-competent organs and reduced the number of nuclei-containing cells in the spleen throughout the entire period of investigation.
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D000921:Antibody-Producing Cells / Q000187:drug effects; D000970:Antineoplastic Agents; D001388:Aziridines / Q000276:immunology*; D001389:Azirines / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D004912:Erythrocytes / Q000276:immunology; D007114:Immunization; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009943:Organophosphorus Compounds / Q000276:immunology; D013154:Spleen / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology
chemical_list: D000970:Antineoplastic Agents; D001388:Aziridines; D001389:Azirines; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D009943:Organophosphorus Compounds; C008880:phosphazine
vernacular_title: Vliianie fosfemida i fopurina na antiteloobrazovanie.