[Pharmacokinetics of mezlocillin in the rabbit eye].
Following intravenous injection of 50 mg/kg Mezlocillin into rabbit eyes the concentrations measured in the aqueous humor were of low-grade therapeutic efficacy. In the vitreous, this dose and form of application had no therapeutic effect. The transfer concentration in the aqueous humor after subconjunctival application of 20 mg Mezlocillin was comparably low. High therapeutic levels in the aqueous humor and even, in isolated cases, traces of Mezlocillin in the vitreous were found after subconjunctival injection of 100 mg.
D000818:Animals; D001082:Aqueous Humor / Q000032:analysis; D005123:Eye / Q000378:metabolism*; D008802:Mezlocillin; D010406:Penicillins / Q000008:administration & dosage / Q000378:metabolism*; D011817:Rabbits; D014822:Vitreous Body / Q000032:analysis
D010406:Penicillins; D008802:Mezlocillin
Untersuchungen zur Pharmakokinetik von Mezlocillin am Kaninchenauge.