[Preliminary study of the physical chemistry and catalytic properties of glutathione-S-transferase from human placenta].
Glutathione-S-transferase activity has been identified in the cytosol of human placenta. The specific activity measured is about 50% of that found in human liver. While some kinetic data have a close correspondence with those attributed to transferases of other sources, the molecular weight (60.000 daltons) and electric properties of this protein are unusual. The inhibitory effect of several non-substrate compounds suggests that also the placental Glutathione-S-transferase may play some role in detoxication of exogenous substances.
D002509:Cephaloridine / Q000494:pharmacology; D005260:Female; D005978:Glutathione / Q000378:metabolism; D005982:Glutathione Transferase / Q000037:antagonists & inhibitors / Q000502:physiology*; D006801:Humans; D008099:Liver / Q000201:enzymology; D008970:Molecular Weight; D010920:Placenta / Q000201:enzymology*; D011247:Pregnancy; D012395:Rose Bengal / Q000494:pharmacology; D013448:Sulfobromophthalein / Q000494:pharmacology; D013696:Temperature
D013448:Sulfobromophthalein; D012395:Rose Bengal; D005982:Glutathione Transferase; D005978:Glutathione; D002509:Cephaloridine
Studio preliminare delle proprieta' catalitiche e chimico fisiche della glutatione-S-transferasi da placenta umana.