Genitourinary malignancy and pseudohyperparathyroidism.
Genitourinary tumors account for half of all documented cases of pseudohyperparathyroidism. The treatment of hypercalcemia is directed toward immediate correction of the electrolyte imbalance and long-term control. These goals are accomplished with volume repletion, calcium normalization and removal of the tumor. Effective therapy includes saline infusion and furosemide. Additional control is obtained with phosphates and/or indomethachin. In refractory cases actinomycin-D or mithramycin is helpful. The first reported case of urethral cancer and second reported case of testicular seminoma producing this syndrome are added to the literature.
D002294:Carcinoma, Squamous Cell / Q000150:complications; D002369:Castration; D004407:Dysgerminoma / Q000150:complications / Q000601:surgery; D005260:Female; D005665:Furosemide / Q000627:therapeutic use; D006801:Humans; D006934:Hypercalcemia / Q000188:drug therapy / Q000209:etiology; D006961:Hyperparathyroidism / Q000150:complications / Q000209:etiology*; D007213:Indomethacin / Q000494:pharmacology; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D010710:Phosphates / Q000627:therapeutic use; D011453:Prostaglandins / Q000096:biosynthesis; D012965:Sodium Chloride / Q000008:administration & dosage / Q000627:therapeutic use; D013736:Testicular Neoplasms / Q000150:complications / Q000601:surgery; D014523:Urethral Neoplasms / Q000150:complications; D014565:Urogenital Neoplasms / Q000150:complications*
D010710:Phosphates; D011453:Prostaglandins; D012965:Sodium Chloride; D005665:Furosemide; D007213:Indomethacin