Metabolism correlates of cocaine-induced stereotypy in rats.
An increase in stereotyped behavior was observed in rats injected daily with cocaine (40 mg/kg, IP), as compared with the first day. This increase persisted 14 days after discontinuation of the drug treatment, and corresponded to increased levels of 3H-cocaine norcocaine and benzoylecgonine in brain. Pretreatment of the animals with SKF-522A, an inhibitor of cocaine demethylation, produced a decrease in stereotypy rating and concomitantly a lower level of 3H-norcocaine in the brain. The role of this metabolite in the production of cocaine-induced stereotyped behavior is discussed.
D000818:Animals; D001519:Behavior / Q000187:drug effects*; D001923:Brain Chemistry / Q000187:drug effects; D003042:Cocaine / Q000037:antagonists & inhibitors / Q000378:metabolism* / Q000494:pharmacology; D005260:Female; D006801:Humans; D011335:Proadifen / Q000494:pharmacology; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects*; D013997:Time Factors
D011335:Proadifen; D003042:Cocaine