[The pharmacology of 3,4-dihydroxyphenyl-alpha-hydroxypropionic acid sodium salt].
Sodium salt of 3,4-dihydroxyphenyl-alpha-hydroxypropionic acid inhibits exploratory behavior and induces hypothermia in mice. The compound enhances central effects of L-DOPA, such as: gross excitation in group, fighting behavior, anticataleptogenic action and hyperthermic effect. The L-DOPA central effects are mitigated by pyridoxal phosphate. The 3,4-dihydroxyphenyl-alpha-hydroxypropionic acid sodium salt abolishes the protective action of pyridoxal phosphate. In vitro this salt inhibits DOPA-decarboxylase. It is suggested that the compound under discussion is a competitive antagonist of L-DOPA, when the latter is involved in reactions with pyridoxal phosphate.
D000374:Aggression / Q000187:drug effects; D000818:Animals; D065105:Aromatic Amino Acid Decarboxylase Inhibitors; D001831:Body Temperature / Q000187:drug effects; D005106:Exploratory Behavior / Q000187:drug effects; D006801:Humans; D007980:Levodopa / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000494:pharmacology; D051379:Mice; D009043:Motor Activity / Q000187:drug effects
D065105:Aromatic Amino Acid Decarboxylase Inhibitors; D007980:Levodopa
K farmakologii natrievoĭ soli 3,4-dioksifenil-al'fa-oksiproiolionovoĭ kisloty.