title: Relationship of intravenous sodium bicarbonate infusions and cerebral intraventricular hemorrhage.
abstract: The incidence of cerebral intraventricular hemorrhage was determined by computed tomography in 100 infants with birth weights less than or equal to 1,500 gm. A comparison of IVH with serum sodium concentrations and the amount of intravenous sodium bicarbonate administered did not reveal a significant relationship. Analysis of the method of infusion of sodium bicarbonate indicated that the rapid infusion of hyperosmolar (M to M/12) sodium bicarbonate is associated with a significantly increased incidence of IVH.
mesh_terms: D001639:Bicarbonates / Q000009:adverse effects*; D002543:Cerebral Hemorrhage / Q000139:chemically induced / Q000209:etiology*; D002552:Cerebral Ventricles / Q000187:drug effects*; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral / Q000009:adverse effects*; D009994:Osmolar Concentration; D011247:Pregnancy; D012964:Sodium / Q000097:blood
chemical_list: D001639:Bicarbonates; D012964:Sodium