Effect of lysine vasopressin on pentylenetetrazol-induced retrograde amnesia in rats.
Lysine vasopressin (1 microgram/rat SC) administered 1 hr prior to either the acquisition trial or 24 hr retention trial facilitated passive avoidance retention. Amnesia was produced when a single 50 mg/kg (IP) injection of pentylenetetrazol was given immediately following the passive avoidance acquisition trial. A single injection of lysine vasopressin (1 microgram/rat SC) administered 1 hr prior to either the acquisition trial or 24 hr retention trial antagonized the amnesia.
D000647:Amnesia / Q000503:physiopathology*; D000648:Amnesia, Retrograde / Q000139:chemically induced / Q000503:physiopathology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D006801:Humans; D008236:Lypressin / Q000494:pharmacology*; D008297:Male; D008568:Memory / Q000187:drug effects; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology; D013997:Time Factors; D014667:Vasopressins / Q000031:analogs & derivatives*
D014667:Vasopressins; D008236:Lypressin; D010433:Pentylenetetrazole