Theophylline concentrations in asthmatic patients after administration of aminophylline.
To test the efficacy of using a weight-derived formula to determine aminophylline dosages, 50 patients hospitalized for treatment of severe asthma were given intravenous aminophylline infusions at a rate of 0.9 mg/kg/hr to a maximum dosage of 1,500 mg/24 hr. Serum theophylline determinations done 12 to 96 hours after institution of this therapy showed levels greater than 20 mg/liter in 34% of these patients. Reliance on weight-derived formulas can be dangerous.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000628:Aminophylline / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D001249:Asthma / Q000097:blood / Q000188:drug therapy*; D005260:Female; D006207:Half-Life; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D013806:Theophylline / Q000097:blood*
D000628:Aminophylline; D013806:Theophylline