[Effect of m-cholinoblockaders and physostigmine on emotional reactivity and catecholamine metabolism in the brain of rats].
In experiments on male albino rats m-choline blocking agents, atropine and benactyzine potentiated the stimulating effect of l-DOPA on emotional reactivity and aggressiveness, while physostigmine antagonized behavioral effects of l-DOPA. Both the choline blocking agents and physostigmine lowered the brain dopamine accumulation rate after introduction of l-DOPA, at the same time raising the level of homovanilic acid dopamine metabolite. It is suggested that the effect of cholinergic compounds on emotional reactivity and aggressiveness of the animals depends in part on the activity of the brain dopaminergic system.
D000374:Aggression / Q000187:drug effects; D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D001535:Benactyzine / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002395:Catecholamines / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004644:Emotions / Q000187:drug effects*; D006801:Humans; D007980:Levodopa / Q000494:pharmacology; D008297:Male; D010830:Physostigmine / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D002395:Catecholamines; D007980:Levodopa; D001535:Benactyzine; D001285:Atropine; D010830:Physostigmine
Vliianie m-kholinoblokatorov i fizostigmina na émotsional'nuiu reaktivnost' i obmen katekholaminov v mozge krys.