Treating acute acetaminophen poisoning with acetylcysteine.
A patient ingested 15.6 gm acetaminophen and sought medical attention after seven hours. At that time, her plasma acetaminophen level was 217 microng/ml. Treatment with acetylcysteine was begun eight hours after the ingestion. The clinical course of this patient was characterized by a mild illness with a minor elevation of liver enzyme values. A number of factors predicted severe hepatotoxicity for this patient had she not received treatment.
D000082:Acetaminophen / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000506:poisoning*; D000111:Acetylcysteine / Q000494:pharmacology / Q000627:therapeutic use*; D000208:Acute Disease; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects; D008875:Middle Aged; D013406:Suicide, Attempted
D000082:Acetaminophen; D000111:Acetylcysteine