[Effect of ethyl alcohol on oxidation-reduction processes in the myocardium].
Evidence is given of disturbances of aerobic oxidative process in the myocardial mitochondria occurring in acute and chronic alcoholic intoxication. A single introduction of alcohol in a dose of 1 and 3 g/kg to rats and dogs produces "hypoxyform" changes in the myocardium, viz. a fall of PO2, a reduced activity of most NAD-independent enzymes, activation of succinate- and lactate-dehydrogenases in a moderate dissociation of oxidative phosphorylation reactions. The damaging effect of the alcohol persists for 24 hours after its one-time introduction. Following a 2-month long alcoholic intoxication there was seen a depressed respiratory activity of the mitochondria and of the study enzymes, except for cytochrome-C-oxidase. It is assumed that the cardiotoxic effect of alcohol is due to the damage of the energy-producing system of the mitochondria.
D000435:Alcoholic Intoxication / Q000378:metabolism*; D000818:Animals; D003579:Cytochrome Reductases / Q000378:metabolism; D005969:Glutamate Dehydrogenase / Q000378:metabolism; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D008928:Mitochondria / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism*; D010085:Oxidative Phosphorylation; D010088:Oxidoreductases / Q000378:metabolism*; D010101:Oxygen Consumption; D051381:Rats; D013385:Succinate Dehydrogenase / Q000378:metabolism
D010088:Oxidoreductases; D007770:L-Lactate Dehydrogenase; D013385:Succinate Dehydrogenase; D005969:Glutamate Dehydrogenase; D003579:Cytochrome Reductases
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