title: Synthesis and biological activity of some 2-aminoimidazoles.
abstract: A review of the literature showed that 2-amino-imidazoles have not benn taken into consideration as antimicrobial agents. Our preliminary data indicating that 2-amino-4(5)-phenylimidazole possessed a moderate in vitro activity prompted us to prepare a limited series of 2-amino-4(5)-arylimidazoles and of some related derivatives. In vitro atimicrobial screening gave evidence of a broad spectrum activity for some of them. Several compounds have been tested also against S. mutans. In particular, 2-amino-4(5)-(4-biphenylyl)-imidazole hydrochloride showed substantial activity in this test, confirmed also against defferent representative strains of S. mutans. When submitted to a plaque inhibition test, it strongly inhibited the plaque forming ability of a S. mutans  strain.
mesh_terms: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis; D001419:Bacteria / Q000187:drug effects; D003731:Dental Caries / Q000517:prevention & control; D005658:Fungi / Q000187:drug effects; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D013295:Streptococcus mutans / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D007093:Imidazoles