Quantitative regularities of development of endogenous infection in irradiated organism (survey of literature).
Statistical analysis of data from the literature and the author's own experimental results was carried out in order to reveal functional dependence between the dose of irradiation and the development of endogenous infection in an irradiated organism. Direct linear dependence was established between the dose of irradiation and the severity of endogenous infection at doses causing death from the "bone-marrow" syndrome in acute radiation sickness. In the case of death from the "intestinal" syndrome, inverse linear dependence can be observed between the dose of irradiation and the culture yield of microbes from internal organs. In this case, the pathological effect on the organism is due to bacterial endotoxins formed during disintegration of microbial cells in the organism. Endogenous infection and endotoxinaemia essentially aggravate the course of acute radiation disease. The importance of endogenous infection in death of the organism is neutralized after irradiation in doses causing death "under the ray".
D000818:Animals; D001769:Blood / Q000382:microbiology; D004307:Dose-Response Relationship, Radiation; D005856:Germ-Free Life; D006168:Guinea Pigs; D007239:Infections / Q000209:etiology* / Q000382:microbiology; D008099:Liver / Q000382:microbiology; D008297:Male; D051379:Mice; D011817:Rabbits; D011833:Radiation Injuries, Experimental / Q000150:complications* / Q000401:mortality; D051381:Rats; D013154:Spleen / Q000382:microbiology; D013223:Statistics as Topic; D014965:X-Rays