[Correlation between the 'active' and 'passive' mechanisms of chlortetracycline penetration in the cells of a sensitive and resistant strains of mycobacteria].
The value of chlortetracycline physical diffusion into the cells of the strains of Mycobacterium citreum sensitive and resistant to tetracyclines was estimated. Exclusion of the active transport was achieved with the use of 4 per cent formalin. It was shown that the scale of the 'passive' penetration of chlortetracycline into the cells of the sensitive and resistant strains was the same. Because of the physical diffusion up to 1/3 the absorbed antibiotic appeared to be transferred into the cells of the sensitive strain. When the sensitive strain was grown on the glucose medium, partial repression of formation of the transport system common for chlortetracycline and oxalacetic acid observed. In case of resistant strains the 'glucose effect' was absent.
D000042:Absorption; D001692:Biological Transport / Q000187:drug effects; D002250:Carbon Radioisotopes; D002751:Chlortetracycline / Q000494:pharmacology*; D003470:Culture Media; D004058:Diffusion; D004352:Drug Resistance, Microbial; D004734:Energy Metabolism / Q000187:drug effects; D005557:Formaldehyde / Q000494:pharmacology; D009154:Mutation; D009161:Mycobacterium / Q000187:drug effects* / Q000378:metabolism; D010071:Oxaloacetates / Q000494:pharmacology
D002250:Carbon Radioisotopes; D003470:Culture Media; D010071:Oxaloacetates; D005557:Formaldehyde; D002751:Chlortetracycline
Sootnoshenie mezhdu "aktivnym" meknanizami proniknoveniia khlortetratsiklina v kletki chuvstvitel'nogo i ustoichivykh shtammov mikobakterii