Effect of cigarette smoke exposure on maturation of the antibody response in spleens of newborn mice.
Balb/c mice were exposed to smoke from Kentucky Reference IRI cigarettes within 24 hr after birth on a Prototype Mark II Walton Horizontal Smoke Exposure Machine for various periods of time up to 10 wk of age. There was no difference in the magnitude of the splenic plaque-forming cells (PFC) response in smoke-exposed and untreated control animals immunized with sheep red blood cells (SRBC) on sequential days up to day 9 postpartum. However, beginning at day 10 and for each subsequent time period assayed thereafter, there was a statistically significant reduction in the number of splenic PFC observed in the smoke-exposed animals. On day 10, the PFC response of smoke-exposed mice was reduced by 33%, on day 14, there was a 60% reduction, whereas animals exposed to smoke from 4-10 wk showed a 90% reduction of the splenic PFC response.
D000818:Animals; D000831:Animals, Newborn; D000906:Antibodies / Q000276:immunology*; D000921:Antibody-Producing Cells / Q000276:immunology; D000941:Antigens / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology; D007114:Immunization; D051379:Mice; D008807:Mice, Inbred BALB C; D010947:Plants, Toxic; D012756:Sheep; D012906:Smoke; D013154:Spleen / Q000276:immunology*; D014026:Nicotiana
D000906:Antibodies; D000941:Antigens; D012906:Smoke