title: Bioelectric activity of chick stato-acoustic ganglion cells in culture.
abstract: Electrical membrane properties were recorded intracellularly from dissociated embryonic chick stato-acoustic ganglion (S-AG) cells cultivated in vitro for 8 days. Most S-AG cells exhibited the complete action potentials with overshoot by passing current and a half of them fired repetitively during single prolonged stimulation. In some S-AG cells with relatively high input resistances, long-term negative after-potentials were clearly observed at the end of repetitive discharges. The action potential was composed of fast and slow components. The former component was blocked by tetrodtoxin (TTX) and the latter one was markedly suppressed by treatment with MnCl2 or verapamil. These data indicate that the action potential from the chick S-AG perikaryon is produced by both Na and Ca mechanisms together.
mesh_terms: D000200:Action Potentials; D000818:Animals; D002118:Calcium / Q000378:metabolism; D002463:Cell Membrane Permeability; D002478:Cells, Cultured; D002642:Chick Embryo; D005724:Ganglia / Q000378:metabolism / Q000502:physiology*; D008345:Manganese / Q000494:pharmacology; D011188:Potassium / Q000378:metabolism; D012964:Sodium / Q000378:metabolism; D013779:Tetrodotoxin / Q000494:pharmacology; D014700:Verapamil / Q000494:pharmacology; D000159:Vestibulocochlear Nerve / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*
chemical_list: D008345:Manganese; D013779:Tetrodotoxin; D012964:Sodium; D014700:Verapamil; D011188:Potassium; D002118:Calcium