[Registration of cytostatic effects on cultured cells in vitro and their current significance for individualized chemotherapy of tumors in advanced ovarian carcinoma].
In vitro tests of cell cultures have revealed individual responses of ovarian carcinomas to various cytostatic agents, the most effective ones being cyclophosphamide and trenimon. The role of pretherapeutical sensibilization tests for the chemotherapy of advanced ovarian carcinomas was investigated in a controlled clinical trial as part of a cooperative study. The survival curves of patients treated individually according to the given test result were at any time more favourable than those of a group nonindividually treated with trenimon. No significance between the two curves could be demonstrated on the basis of our preliminary results.
D000179:Acrylates / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002478:Cells, Cultured; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D066298:In Vitro Techniques; D008727:Methotrexate / Q000627:therapeutic use; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000473:pathology; D013997:Time Factors; D014747:Vinblastine / Q000627:therapeutic use
D000179:Acrylates; D000970:Antineoplastic Agents; D014747:Vinblastine; D003520:Cyclophosphamide; D005472:Fluorouracil; D008727:Methotrexate
Zur Erfassung zytostatischer Effekte an Zellkulturen in vitro und deren gegenwärtige Bedeutung für eine individualisierte Tumorchemotherapie des fortgeschrittenen Ovarialkarzinoms.