Immunofluorescent localization of thyroglobulin--autoantibody producing cells in various organs of obese strain (OS) chickens.
The Obese strain (OS) of White Leghorn chickens develops a spontaneous autoimmune thyroiditis with circulating thyroglobulin-autoantibodies (Tg-AAb) similar to human Hashimoto thyroiditis. The paper describes attempts to localize the site of Tg-AAb production in various organs of these animals using the immunofluorescence method. Tg-AAb producing plasma cells and germinal centers could be detected in the infiltrated thyroid glands but not in spleen, bone marrow, coecal tonsils, thymus, bursa of Fabricius and Harderian glands.
D000818:Animals; D000921:Antibody-Producing Cells; D001323:Autoantibodies; D001854:Bone Marrow Cells; D002060:Bursa of Fabricius / Q000166:cytology; D002645:Chickens; D006243:Harderian Gland / Q000166:cytology; D010950:Plasma Cells / Q000276:immunology; D013154:Spleen / Q000166:cytology; D013950:Thymus Gland / Q000166:cytology; D013954:Thyroglobulin; D013961:Thyroid Gland / Q000166:cytology*; D013966:Thyroiditis / Q000276:immunology
D001323:Autoantibodies; D013954:Thyroglobulin