title: Aspirin- and bile- induced acute erosive gastritis: its prevention by metiamide therapy.
abstract: Aspirin or bile administered by esophageal intubation to rats produced acute gastric erosions. These injuries could have been prevented by the prior administration by esophageal intubation of metiamide, a histamine H2 receptor antagonist that is known to inhibit gastric acid secretion.
mesh_terms: D000208:Acute Disease; D000818:Animals; D001241:Aspirin / Q000009:adverse effects*; D001647:Bile Acids and Salts / Q000009:adverse effects*; D005753:Gastric Mucosa / Q000473:pathology*; D005756:Gastritis / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control; D008297:Male; D008785:Metiamide / Q000627:therapeutic use*; D051381:Rats; D013890:Thiourea / Q000031:analogs & derivatives*
chemical_list: D001647:Bile Acids and Salts; D008785:Metiamide; D013890:Thiourea; D001241:Aspirin