The prevention by creatinol O-phosphate of myocardial lesions evoked by isoprenaline.
Isoprenaline 30 mg/kg has been injected subcutaneously in rats pretreated or not with Creatinol O-phosphate (200 mg/kg intraperitoneously). Isoprenaline-induced cardionecrosis and the associated alterations of the ionic composition of the heart were reduced when Creatinol O-phosphate was injected 4 hr before isoprenaline.
D000818:Animals; D009202:Cardiomyopathies / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D003401:Creatine / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D005260:Female; D007477:Ions / Q000378:metabolism; D007545:Isoproterenol / Q000037:antagonists & inhibitors*; D009206:Myocardium / Q000473:pathology; D009336:Necrosis; D051381:Rats; D013997:Time Factors
D007477:Ions; D007545:Isoproterenol; D003401:Creatine