Evaluation of a 4% gelatin solution in the treatment of canine haemorrhagic shock.
The effects of volume replacement with 4% gelatin containing 1% glycine at pH 5.8 and 6.4 on the changes in mean arterial blood pressure (MABP) and blood levels of glucose, lactate and urea following acute haemorrhage in dogs were studied. Comparison was made with dogs given homologous blood. Dogs bled 30% of blood volume, maintained in shock for 30 min, and infused with gelatin solutions, showed values of MABP, blood glucose, lactate and urea nitrogen insignificantly different from dogs similarly bled and infused with homologous blood. The responses obtained in dogs infused with gelatin at pH 5.8 were better than at pH 6.4.
D000208:Acute Disease; D000818:Animals; D001803:Blood Transfusion; D001804:Blood Transfusion, Autologous / Q000379:methods; D004285:Dogs; D005260:Female; D008297:Male; D011097:Polygeline / Q000008:administration & dosage / Q000627:therapeutic use*; D011108:Polymers / Q000627:therapeutic use*; D012771:Shock, Hemorrhagic / Q000188:drug therapy* / Q000628:therapy
D011108:Polymers; D011097:Polygeline