[Effect of preliminary administration of allogenic cells on transplantation immunity in mice receiving cyclophosphamide].
It was shown that injection of 1 X 10(8) spleen cells from C57Bl/6 mice to CBA mice one day before the injection of cyclophosphamide (CY) helped the take of 2 X 10(7) allogeneic or semiallogeneic cells (injected for the second time 3 to 6 hours after C)). Criterion of survival is the ability of the donor cells to produce antibodies to sheep red blood cells in the recipients tolerant of this antigen. Injection of 1 X 10(8) allogeneic cells two days before CY produces no protective effect. Killer-cells proved to appear on the second day after the immunization with allogeneic cells; their peak was reached on the 5th day. The data obtained suggest that CY eliminated the recipients' lymphocytes, which responded to the transplantation antigens, whereas the killer-cells already formed were stable to the CY action.
D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects; D002452:Cell Count; D003520:Cyclophosphamide / Q000494:pharmacology*; D005260:Female; D006183:H-2 Antigens; D006824:Hybridization, Genetic; D007156:Immunologic Memory; D007694:Killer Cells, Natural / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D013154:Spleen / Q000637:transplantation*; D014181:Transplantation Immunology / Q000187:drug effects; D014184:Transplantation, Homologous
D006183:H-2 Antigens; D003520:Cyclophosphamide
Vliianie predvaritel'nogo vvedeniia allogennykh kletok na transplantatsionnyĭ immunitet u mysheĭ, poluchivshikh tsiklofosfamid.