Receptivity of female rats.
Receptivity of female rats has been investigated under chronic experimental conditions. A receptivity index has been worked out for quantitative evaluation. It proved suitable for disclosing stimulatory (2.5 mg noretynodrel, oestradiol propionate) as well as inhibitory (etynodiol diacetate) effects. 2.5 mg noretynodrel has a biphasic effect; causing an inhibition and later an increase in receptivity. Receptivity of untreated female rats is low and can be increased by various steroids; the best treatment was 50 micrograms oestradiol monopropionate administered twice weekly, but this resulted in an inverse mating reaction, with frequent copulations in every phase of the cycle. In untreated females the number of copulations varied widely. Previous deliveries did not influence receptivity and frigidity was also observed.
D000818:Animals; D003307:Copulation; D004958:Estradiol / Q000494:pharmacology; D004971:Estrus / Q000187:drug effects; D005040:Ethynodiol Diacetate / Q000494:pharmacology; D005260:Female; D008656:Mestranol / Q000494:pharmacology; D009641:Norethynodrel / Q000494:pharmacology; D010298:Parity; D011247:Pregnancy; D051381:Rats; D012726:Sexual Behavior, Animal / Q000187:drug effects
D004958:Estradiol; D005040:Ethynodiol Diacetate; D009641:Norethynodrel; D008656:Mestranol