Use of 125I-fibrinogen kinetic data to detect disseminated intravascular coagulation and deposition of fibrin in patients with metastatic cancer.
A technique using computerized data handling for following the fate of 125I-fibrinogen through various physiological compartments is presented. Its use in detecting fibrin build up in patients with metastatic tumors and cancer-caused DIC is explained. An increase in j3u (fractional catabolic rate as seen in the urine data) throughout the course of a study was found to be an important indicator of extravascular fibrin build up.
D004211:Disseminated Intravascular Coagulation / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism; D005337:Fibrin; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D008433:Mathematics; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism
D005337:Fibrin; D005340:Fibrinogen