[Induction of lung maturation in pending premature delivery and scheduled premature delivery].
At the Women's Hospital of the Medical Academy of Erfurt we have examined the efficiency of dexamethasone on fetal lungs maturation at imminent premature birth and planned untimely delivery. Dexamethasone was given in a randomized series at a dosage of 12-mg per day orally on three successive days. The effectiveness of induction was measured at the percentage of the total phospholipid fraction in the amniotic fluid and at the mortality of RDS in both groups. A successful induction with dexamethasone we can only reach after the 32nd week of pregnancy.--Because this effect is not always continuous, we recommend to make the induction of fetal lungs maturation with dexamethasone and--if it necessary--its repetition after one week conditional upon the content of total phospholipids in amniotic fluid.
D000328:Adult; D000649:Amniocentesis; D000653:Amniotic Fluid / Q000032:analysis; D003907:Dexamethasone / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000517:prevention & control*; D008168:Lung / Q000187:drug effects* / Q000254:growth & development; D008297:Male; D007752:Obstetric Labor, Premature; D010743:Phospholipids / Q000032:analysis; D011247:Pregnancy
D010743:Phospholipids; D003907:Dexamethasone
Zur Induktion der Lungenreife bei drohender Frühgeburt und geplanter vorzeitiger Entbindung.