[Antibody-forming capacity of mouse spleen cells after hypoxic hypoxia and the administration of erythropoietin].
In CBA mice the absolute and relative (per 10(6) spleen cells) number of antibody-forming cells (AFC) in the spleen was cut by half on the 1st, 4th, and 7th days after acute hypoxia (12 hours, 6700 m), and on the 1st and 4th days after cessation of chronic hypoxia (16 days, 16 hours, 6700 m). The number of AFC in the spleen returned to the normal level on the 7th day after cessation of chronic hypoxia. Single or double erythropoietin injections caused approximately a 1.15--2-fold decrease in spleen AFC number in posthypoxic mice in comparison with control animals.
D000818:Animals; D000917:Antibody Formation; D000921:Antibody-Producing Cells / Q000187:drug effects*; D004921:Erythropoietin / Q000276:immunology*; D000860:Hypoxia / Q000276:immunology*; D007114:Immunization; D051379:Mice; D008808:Mice, Inbred CBA; D013154:Spleen / Q000276:immunology*; D013997:Time Factors
D004921:Erythropoietin
Antiteloobrazuiushchaia sposobnost' kletok selezenki mysheĭ posle gipoksicheskoĭ gipoksii i vvedeniia éritropoétina.