[Effect of N-nitrosoethylurea dosage and postnatal x-ray irradiation on transplacental blastomogenesis in mice].
In transplacental exposure to nitrosoethylurea in a dose of 2 mg/Kg the frequency of occurrence of different neoplasms in mice would not change as compared with a dose of 20 mg/Kg. However, in a dose of 2 mg/Kg the time of lung tumor development was prolonged. Postnatal roentgen irradiation increased the incidence of lung adenomas and ovarian tumors in female mice, exposed in embryogenesis to NEU effect in a dose of 2 mg/Kg; male mice showed a somewhat delayed development of tumors. In animals, subjected to NEU effect transplacentally in a dose of 20 mg/Kg, postnatal roentgen irradiation resulted in the appearance of lung adenocarcinomas, tumors of other lacolizations being developed neither in female nor in male mice.
D000236:Adenoma / Q000139:chemically induced / Q000209:etiology*; D000818:Animals; D005038:Ethylnitrosourea / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D005333:Fetus / Q000187:drug effects*; D008175:Lung Neoplasms / Q000139:chemically induced / Q000209:etiology*; D008431:Maternal-Fetal Exchange; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000209:etiology*; D009381:Neoplasms, Radiation-Induced; D009607:Nitrosourea Compounds / Q000008:administration & dosage*; D010051:Ovarian Neoplasms / Q000139:chemically induced / Q000209:etiology*; D010920:Placenta; D011247:Pregnancy
D009607:Nitrosourea Compounds; D005038:Ethylnitrosourea
Vliianie dozy N-nitrozoetilmocheviny i postnatal'nogo rentgenovskogo oblucheniia na transplatsentarnyĭ blastomogenez u mysheĭ.