[Newer antimycotics. IV. Aryl-hydrazones of mesoxalic-acid-seminitril-hydrazid (author's transl)].
The author produced a number of aryl-hydrazones of mesoxalic-acid-seminitril-hydrazide and their N2-acyl-derivatives, farther the halogeno-substituted phenyl-hydrazones of mesoxalic-acid-seminitril-hydrazones, and investigated their fungistatic efficiency in vitro. From the author's results it can be concluded, that 2-, 3- and 4-chloro-phenyl-hydrazones of mesoxalic-acid-siminitril-hydrazide exert a strong fungistatic effect on Trichophyton- and Epidermophyton-species, but they are inactive on other fungi-strains. Their N2-acyl-derivatives, farther with aldehydes and ketones formed derivatives of the previous compounds exert any fungistatic effect neither on Trichophyton- and Epidermophyton-species, nor on other fungi-strains. From this it can be concluded, that the fungistatic activity of the investigated compounds is strong structur-specific.
D000935:Antifungal Agents; D003883:Arthrodermataceae / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D006835:Hydrazones / Q000494:pharmacology*; D003904:Mitosporic Fungi / Q000187:drug effects; D009570:Nitriles / Q000494:pharmacology; D012232:Rhizoctonia / Q000187:drug effects; D014588:Ustilago / Q000187:drug effects; D015003:Yeasts / Q000187:drug effects
D000935:Antifungal Agents; D006835:Hydrazones; D009570:Nitriles
Neuere Antimycotika. IV. Arylhydrazone des Mesoxalsäureseminitril-hydrazids.