[Dose finding for bronchospasmolytic drugs in clinical practice (authors' transl)].
The paper deals with methods of investigation, importance of provocation tests for investigations in healthy volunteers and patients, need for selection criteria, the "ideal" patient and methods of determining dose-response and time-response of effect and side-effects. The good correlation of the results in clinical and animal pharmacological studies and the problems of the correlation with pharmacokinetic data regarding the inhalation of bronchospasmolytic agents is discussed.
D001980:Bronchi / Q000187:drug effects; D001993:Bronchodilator Agents / Q000008:administration & dosage*; D004341:Drug Evaluation / Q000379:methods; D006801:Humans
D001993:Bronchodilator Agents
Dosisfindung von Bronchospasmolytika in der Klinik