[Retrobulbular tissue changes following TSH administration and influence of various drugs in rats].
Our results demonstrate that the thyreotropin induced exophthalmus is a useful model for testing the efficacy of drugs in animal experiments. Concerning the exophthalmus producing tissue factors till now only qualitative results could be offered. Measuring the incorporation of 3H methionine the statements could be improved quantitatively. Hyaloronidase markedly reduced the thyreotropin induced exophthalmus. L-triiodothyronine, D-triiodothyronine. L-thyroxine, D-thyroxine and hydrocortisone had no certain influence on the TSH induced alterations.
D000818:Animals; D006111:Graves Disease / Q000139:chemically induced*; D006854:Hydrocortisone / Q000494:pharmacology; D008297:Male; D008715:Methionine / Q000378:metabolism; D051381:Rats; D013961:Thyroid Gland / Q000187:drug effects / Q000502:physiology* / Q000503:physiopathology; D013972:Thyrotropin / Q000494:pharmacology*; D013974:Thyroxine / Q000494:pharmacology; D014284:Triiodothyronine / Q000494:pharmacology
D014284:Triiodothyronine; D013972:Thyrotropin; D008715:Methionine; D013974:Thyroxine; D006854:Hydrocortisone
Retrobulbäre Gewebsveränderungen nach TSH Applikation und ihre Beeinflussung durch verschiedene Pharmaka bei Ratten.