title: 3H-thymidine incorporation (DNA synthesis) and radiotoxicity in the ovary of the Japanese quail before and during follicle formation.
abstract: No evidence was found for ribosomal DNA amplification in the oocytes of the Japanese quail, before or during folliculogenesis. DNA synthesis in the somatic cells, involved in follicle formation, starts at the medullar side of the basement membrane. The localized sterilization of the quail ovary after administration of 3H-thymidine (3H-TdR) seems to be due to radiation-induced lesions in the follicle forming somatic cells, rather than to direct radiation damage of the oocyte.
mesh_terms: D000818:Animals; D003370:Coturnix / Q000378:metabolism*; D004247:DNA / Q000096:biosynthesis*; D005260:Female; D009865:Oocytes / Q000378:metabolism / Q000502:physiology / Q000528:radiation effects; D010053:Ovary / Q000378:metabolism* / Q000502:physiology / Q000528:radiation effects; D013936:Thymidine / Q000378:metabolism
chemical_list: D004247:DNA; D013936:Thymidine