Muscarinic hyposensitivity in the developing rat pretreated with 6-hydroxydopa.
Atropine-induced locomotor stimulation was investigated in the developing rat pretreated with 6-hydroxydopa at birth. The locomotor stimulation by atropine was first observed on day 20 and gradually increased with age. The treatment with 6-hydroxydopa potentiated atropine-induced locomotor stimulation on days later than day 20 and inhibited a pilocarpine-induced catalepsy on day 30. This suggests that central cholinergic neurons, probably in the neostriatum, reach functional maturity between 15 and 20 days, and that the pretreatment with 6-hydroxydopa induced muscarinic hyposensitivity in the developing rat.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002375:Catalepsy / Q000139:chemically induced; D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004298:Dopamine / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D010275:Parasympathetic Nervous System / Q000187:drug effects; D010862:Pilocarpine / Q000494:pharmacology; D051381:Rats; D011950:Receptors, Cholinergic / Q000187:drug effects*; D011976:Receptors, Muscarinic / Q000187:drug effects*; D013997:Time Factors
D011950:Receptors, Cholinergic; D011976:Receptors, Muscarinic; D010862:Pilocarpine; C001388:6-hydroxydopa; D004295:Dihydroxyphenylalanine; D001285:Atropine; D004298:Dopamine