Severe hemolytic disease of the newborn associated with anti-JSb.
The red blood cells of the group A infant of a group O central African Negro woman of the Zezuru tribe with anti-Lea and anti-JSb in her serum were found to be strongly agglutinated by a commerical antiglobulin reagent six days after birth. The high concentration of bilirubin in the infant's serum gradually decreased but he became profoundly anemic and, in the absence of a suitable donor, was successfully transfused with blood from his mother. Subsequent tests using the maternal anti-JSb diluted one in ten to avoid agglutination by the anti-Lea showed that the frequency of the JS(b-) phenotype in group O Zezuru is approximately one per cent.
D000017:ABO Blood-Group System; D001663:Bilirubin / Q000097:blood; D044383:Black People; D001789:Blood Group Antigens; D001803:Blood Transfusion; D004899:Erythroblastosis, Fetal / Q000276:immunology* / Q000628:therapy; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D013019:South Africa
D000017:ABO Blood-Group System; D001789:Blood Group Antigens; D001663:Bilirubin