title: [The effect of chronic renal insufficiency with and without dialysis therapy on the manganese content of various human organs].
abstract: On the basis of the organ values of nine decreased, formerly with Al (OH)3 treated patients with renal insufficiency without dialysis and 15 patients with dialysis their Mn-state was investigated in comparison to 60 control persons comparable as to age and sex. The dialysis patients for a considerable part died of the so-called dialysis encephalopathy three to five years after the beginning of the Al-treatment. In all investigated nine organs with the exception of the blood of the dialysed patients (liver, hair of the head, myocardium, brain, rib, lung and testicle) the Mn-content was, in comparison to the control persons, essentially, partly highly significantly reduced. These findings were discussed in various kinds of animals in connection with the skeletal and nervous disturbances conditioned by the Mn-deficiency. It may not be excluded that the Al-hydroxyde used for the phosphate binding protects also another essential trace elements and particularly Mn from resporption and has an antagonistic influence on the Mn-metabolism, respectively. Animal experiments must clarify the complex mentioned.
mesh_terms: D000367:Age Factors; D000536:Aluminum Hydroxide / Q000009:adverse effects* / Q000494:pharmacology; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism* / Q000628:therapy; D008297:Male; D008345:Manganese / Q000032:analysis / Q000172:deficiency*; D006435:Renal Dialysis / Q000009:adverse effects*; D012737:Sex Factors; D014018:Tissue Distribution
chemical_list: D008345:Manganese; D000536:Aluminum Hydroxide
vernacular_title: Der Einfluss chronischer Niereninsuffizienz mit und ohne Dialysetherapie auf den Mangangehalt verschiedener Organe des Menschen.