[Cytopathic effect of the tularemia microbe on a culture of peritoneal macrophages].
Morphological analysis of the process of interaction of tularemia microbe strains differing by virulence with macrophages demonstrated that all these strains produced a lethal effect on macrophages obtained from the animales sensitive to the infection. The macrophages obtained from the animals were but little sensitive to tularemia and were resistant to the action of the causative agent of this infection. The data obtained led to a supposition on the presence in the tularemia causative agent of a factor responsible for its lethal action on the macrophages.
D000818:Animals; D000942:Antigens, Bacterial; D001202:Ascitic Fluid / Q000166:cytology; D001427:Bacterial Toxins / Q000032:analysis*; D002478:Cells, Cultured; D005604:Francisella tularensis / Q000032:analysis / Q000276:immunology / Q000472:pathogenicity*; D006168:Guinea Pigs; D008264:Macrophages / Q000382:microbiology*; D051379:Mice; D013045:Species Specificity; D014774:Virulence
D000942:Antigens, Bacterial; D001427:Bacterial Toxins
Izuchenie tsitopaticheskogo deĭstviia tularemiinogo mikroba na kul'turu peritoneal'nykh makrofagov.