title: The management of testicular tumors in children.
abstract: Of 43 testicular tumors in children seen at the Children's Hospital Medical Center and Sidney Farber Cancer Institute 33 were malignant. These tumors occurred primarily in young children. Any solid scrotal mass in an infant must be considered malignant until proved otherwise. Primary emphasis is placed on the 20 cases of embryonal cell carcinoma. Of 9 patients who underwent only orchiectomy 5 have died, whereas all 11 patients who received combination therapy have survived. We recommend radical inguinal orchiectomy, extended unilateral retroperitoneal lymphadenectomy and adjuvant chemotherapy in repeated courses for 2 years. Radiotherapy is withheld if the lymphadenectomy is negative.
mesh_terms: D002369:Castration; D002648:Child; D002675:Child, Preschool; D002822:Choriocarcinoma / Q000628:therapy; D003609:Dactinomycin / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D007984:Leydig Cell Tumor / Q000628:therapy; D008197:Lymph Node Excision; D008297:Male; D009362:Neoplasm Metastasis; D012509:Sarcoma / Q000628:therapy; D013724:Teratoma / Q000628:therapy*; D013736:Testicular Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*
chemical_list: D003609:Dactinomycin