Na-dependent Li-transport in primary nerve cell cultures.
Primary cultures from chick embryonic brain were used to study the steady state distribution of lithium. The intra/extracellular Li+ ratio decreased by enhancing the external Na+ concentration. Ouabain did not influence this unequality. A phloretin-sensitive component was revealed in the Li uptake at low Na+ concentration. The findings might suggest the existence of a Na+-dependent Li+ countertransport system in these brain cell cultures.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002463:Cell Membrane Permeability / Q000187:drug effects; D002478:Cells, Cultured; D002642:Chick Embryo; D008094:Lithium / Q000378:metabolism*; D010042:Ouabain / Q000494:pharmacology; D010693:Phloretin / Q000494:pharmacology; D012964:Sodium / Q000494:pharmacology*
D010042:Ouabain; D008094:Lithium; D012964:Sodium; D010693:Phloretin