Human metabolism and steroid contraceptives. Part 2.
Biochemical studies on large groups of apparently healthy women taking oral contraceptives are intended to find which organs and tissues are most stressed, in the hope than an indication of clinical side effects will result. If contraceptive steroid dose is reduced, the incidence of systemic side effects decreases and this correlates well with the decreased abnormality of many metabolic and biochemical parameters. Reduction of dosage has an equivocal effect on gynaecological side affects-some increase, some decrease. An account is given of the possible relationship between clinical side effects of oral contraceptives, and dose-related changes in plasma proteins, vitamin status and tissue enzymes.
D001205:Ascorbic Acid / Q000097:blood; D003276:Contraceptives, Oral / Q000378:metabolism*; D003280:Contraceptives, Oral, Synthetic / Q000009:adverse effects / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D006261:Headache / Q000139:chemically induced; D006801:Humans; D006973:Hypertension / Q000139:chemically induced; D007989:Libido; D008297:Male; D008995:Monoamine Oxidase / Q000097:blood; D011388:Prolactin / Q000097:blood; D011736:Pyridoxine / Q000097:blood; D011960:Receptors, Estrogen / Q000378:metabolism; D012738:Sex Hormone-Binding Globulin / Q000097:blood; D013831:Thiamine / Q000097:blood
D003276:Contraceptives, Oral; D003280:Contraceptives, Oral, Synthetic; D011960:Receptors, Estrogen; D012738:Sex Hormone-Binding Globulin; D011388:Prolactin; D008995:Monoamine Oxidase; D011736:Pyridoxine; D001205:Ascorbic Acid; D013831:Thiamine