[2-Carbethoxymethylene-thiazolidones-(4), a novel series of Heterocycles with choleretic properties].
Base-induced condensation of alpha-mercapto-carboxylic esters with  activated acetonitriles yields 2-methylene-thiazolidones-(4). The paper presented describes the development of ethyl (Z)-(3-ethyl-4-oxo-5-piperidino-thiazolidin-2-ylidene) acetate (30; piprozoline, Gö 919, Probilin), a novel choleretic with exocrin pancreas stimulating and hepatoprotective properties, by following-up the choleretic parent compound 2, which belongs to the 2-carbethoxymethylene-thiazolidones-(4) series. Synthesis and properties of piprozoline are reported. Structure-activity relationship is discussed in short.
D000818:Animals; D002756:Cholagogues and Choleretics / Q000138:chemical synthesis*; D007928:Lethal Dose 50; D051379:Mice; D013057:Spectrum Analysis; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
D002756:Cholagogues and Choleretics; D013844:Thiazoles
2-Carbäthoxymethylen-thiazolidone-(4), eine neue Klasse von Heterozyklen mit choleretischen Eigenschaften