Dynamics of local-anesthetic compounds in regional anesthesia.
The clinical effectiveness and safety of compounded mixtures of lidocaine + bupivacaine and chloroprocaine + bupivacaine for either epidural or brachial-plexus block was studied in 48 adult patients. Of the several alternatives, chloroprocaine + bupivacaine with epinephrine was found the best choice for patients with typical plasma cholinesterase.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000765:Anesthesia, Conduction; D000767:Anesthesia, Epidural; D000779:Anesthetics, Local / Q000008:administration & dosage* / Q000097:blood; D001917:Brachial Plexus; D002045:Bupivacaine / Q000008:administration & dosage / Q000097:blood; D002802:Cholinesterases / Q000097:blood; D004338:Drug Combinations; D004837:Epinephrine / Q000008:administration & dosage / Q000494:pharmacology; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage / Q000097:blood; D008875:Middle Aged; D009407:Nerve Block; D011343:Procaine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000097:blood; D013997:Time Factors
D000779:Anesthetics, Local; D004338:Drug Combinations; D011343:Procaine; D008012:Lidocaine; D002802:Cholinesterases; D002045:Bupivacaine; D004837:Epinephrine