[Two years feeding toxicity study of tamarind seed polysaccharide in rats (author's transl)].
Tamarind seed polysaccharide (Glyloid) was incorporated at the level of 4, 8, 12% in a standard commercial diet and fed ad lib. to male and female rats for 2 years. No significant changes were noted in the behavior, mortality, body weight, food intake, biochemical analysis of urine and blood, hematological test, organ weight and histopathological findings of rats receiving Glyloid. In all groups containing control group, spontaneous diseases with aging, such as myocardial change, nephropathy, mammary tumor (in female), pituitary tumor etc., were seen. These diseases played important role as the cause of death of the dead rats.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects; D005260:Female; D007674:Kidney Diseases / Q000139:chemically induced; D008297:Male; D008660:Metabolism / Q000187:drug effects; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009929:Organ Size / Q000187:drug effects; D010946:Plants, Medicinal; D011134:Polysaccharides / Q000097:blood / Q000633:toxicity*; D051381:Rats; D012639:Seeds; D012737:Sex Factors; D013997:Time Factors
D011134:Polysaccharides; C018558:glyloid