[Effect of piracetam on some manifestations of the effects of ethanol and acetaldehyde].
An experimental study of pyracetam (2-pyrrolidonacetamide) showed it capable to mitigate some behavioral and toxic manifestations of the action exerted by alcohol in tests on mice and rats, such as those of the "open field", "conflict situation", "rotating rod" and righting reflex. Pyracetam also attenuated some toxic symptoms of acetaldehyde in mice. It shortened the duration of coma, lessened the intensity of convulsive seizures, but it had no influence on the lethal effect of acetaldehyde. The type of the relation between doses and effects suggests the observed antagonism to be of a nonspecific nature.
D000079:Acetaldehyde / Q000037:antagonists & inhibitors / Q000506:poisoning*; D000435:Alcoholic Intoxication / Q000150:complications / Q000188:drug therapy*; D000818:Animals; D003128:Coma / Q000188:drug therapy / Q000209:etiology; D000431:Ethanol / Q000037:antagonists & inhibitors; D006801:Humans; D051379:Mice; D009069:Movement Disorders / Q000188:drug therapy / Q000209:etiology; D010889:Piracetam / Q000627:therapeutic use*; D011760:Pyrrolidinones / Q000627:therapeutic use*; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy
D011760:Pyrrolidinones; D000431:Ethanol; D000079:Acetaldehyde; D010889:Piracetam
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