title: [Effect of carbidine on the sex glands of rats chronically exposed to ethanol].
abstract: In experiments on rats it was shown that carbidine injected intramuscularly for two weeks does not effect gonadotropic action in a dose effective in experimental therapy of alcohol dependence (4 mg/kg). The drug neither potentiates adverse after-effects of chronic action of ethanol on ovo- and spermatogenesis nor slows down the course of the reparative processes in the gonads after ethanol is discontinued. However, further regressive changes in the gonadal generative elements were recorded in administering carbidine against the background of continued use of ethanol.
mesh_terms: D000437:Alcoholism / Q000188:drug therapy* / Q000473:pathology; D000818:Animals; D002243:Carbolines / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007211:Indoles / Q000009:adverse effects*; D008297:Male; D009866:Oogenesis / Q000187:drug effects; D010049:Ovarian Diseases / Q000139:chemically induced*; D010053:Ovary / Q000473:pathology; D051381:Rats; D013091:Spermatogenesis / Q000187:drug effects; D013733:Testicular Diseases / Q000139:chemically induced*; D013737:Testis / Q000473:pathology
chemical_list: D002243:Carbolines; D007211:Indoles
vernacular_title: Vliianie karbidina na polovye zhelezy krys pri khronicheskom vozdeĭstvii étanola.