Modification of hepatotoxic effects of aflatoxin B1 in rabbits by immunization.
Reduction of acute toxic effect of aflatoxin B1 was achieved by immunizing the rabbits with small amounts of bovine serum albumin-aflatoxin B1 conjugate. Rabbits after immunization showed lower mortality, near normal serum isocitric dehydrogenase activity, no abnormality in livers when challenged with a single dose of aflatoxin B1. The results suggest that immunization might be used prophylactically against aflatoxicosis.
D000348:Aflatoxins / Q000276:immunology*; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D007114:Immunization; D007521:Isocitrate Dehydrogenase / Q000097:blood; D011817:Rabbits; D012710:Serum Albumin, Bovine / Q000276:immunology
D000348:Aflatoxins; D012710:Serum Albumin, Bovine; D007521:Isocitrate Dehydrogenase