title: [Obtaining 14-oxycarminomycin and a study of its antitumor activity].
abstract: The authors obtained  14-oxykarminomycin by alkaline hydrolysis of 14-bromokarminomycin. On two-fold  intravenous administration to mice with lymphosarcoma, strain L10-1, 14-oxycarminomycin showed the same toxicity as karminomycin. The preparation had the same selective antitumor activity as karminomycin.
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis*; D002360:Carubicin / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D004341:Drug Evaluation; D006868:Hydrolysis; D007928:Lethal Dose 50; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy
chemical_list: D000903:Antibiotics, Antineoplastic; C015416:14-oxycarminomycin; D002360:Carubicin
vernacular_title: Poluchenie 14-oksikarminomitsina i izuchenie ego protivoopukholevoĭ aktivnosti.