title: Antioxidative activity of lipids in mice during aging and administration of an antioxidant with gerontological protective action.
abstract: Changes in the antioxidative activity (AOA) of the liver were studied during natural aging in noninbred and C3HA mice and during administration of the synthetic anti-oxidant 2-ethyl-6-methyl-3-hydroxypyridine hydroxypyridine hydrochloride to the animals, and the effect of the doses of this compound on the level of AOA in the liver of animals aged 2 months also was investigated. Liver AOA in mice was found to decrease during aging; the decreae in animals with tumors was found to be two or three times slower than in animals without tumors. Administration of the compound after the age of 8 months led to a considerable increase in liver AOA, and this may evidently account for the considerable lengthening of the life of the experimental animals.
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism; D000375:Aging / Q000187:drug effects*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism; D008136:Longevity / Q000187:drug effects; D008325:Mammary Neoplasms, Experimental / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains; D011725:Pyridines / Q000494:pharmacology*; D013154:Spleen / Q000378:metabolism
chemical_list: D000975:Antioxidants; D011725:Pyridines