title: Anthelmintic control of concurrent Hymenolepis nana and Syphacia obvelata infections in the mouse with uredofos.
abstract: Tests were made to determine the efficacy of uredofos in either the diet or drinking water for controlling induced Hymenolepis nana and naturally acquired Syphacia obvelata infections in the mouse. Four levels of administration (50, 75, 100, and 125 parts per million) were used in a 6-day drugdiet assay. Consistent removal of Hymenolepis nana occurred only at 125 parts per million, whereas removal Syphacia obvelata was complete at all levels. The disodium salt of uredofos was given in the drinking water. Three levels of administration (12, 18 and 25 mg/kg) were used, and the treatment period was limited to 24 hours. Complete removal of Hymenolepis nana occurred at 25 mg/kg and Syphacia obvelata was completely eliminated at all levels.
mesh_terms: D000284:Administration, Oral; D000821:Animal Feed; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000627:therapeutic use*; D006925:Hymenolepiasis / Q000150:complications / Q000188:drug therapy / Q000662:veterinary*; D008297:Male; D051379:Mice; D009349:Nematode Infections / Q000150:complications / Q000188:drug therapy / Q000662:veterinary*; D009943:Organophosphorus Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D010124:Oxyuroidea; D010671:Phenylurea Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D012376:Rodent Diseases / Q000188:drug therapy*; D014867:Water
chemical_list: D000871:Anthelmintics; D009943:Organophosphorus Compounds; D010671:Phenylurea Compounds; D014867:Water