[The effects of intratympanally applied streptomycin-sulfate on the ipsi- and contralateral hearing potentials in the guinea pig (author's transl)].
11 Guinea pigs had a 50% streptomycin-sulfate solution injected into the middle ear. Complete loss of function of the peripheral vestibular organ occurred after two days, as was detectable by means of the caloric test. The high-degree decrease of the microphonic-potentials and the compound action potential was significant. Threshold and adaptation of the potentials of the opposite side were not affected. The results are discussed with regard to the treatment of Menière's disease by means of intratympanally applied streptomycin.
D000200:Action Potentials / Q000187:drug effects*; D002150:Caloric Tests; D004432:Ear, Middle; D006311:Hearing Disorders / Q000139:chemically induced; D008575:Meniere Disease / Q000188:drug therapy; D013307:Streptomycin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use
D013307:Streptomycin
Schädigung gleich- und gegenseitiger Hörpotentiale des Meerschweinchens nach intratympanaler Applikation von Streptomycinsulfat.