title: [Systemic lupus erythematosus in twins (author's transl)].
abstract: A report is given of systemic lupus erythematosus (SLE) in monozygotic twins. One sister developed coombs-positive haemolytic anaemia at the age of 11 years and suffered from five haemolytic crises over a period of 8 months. SLE could not be proven at that time, but following a 3-year symptom-free period, characteristic clinical and immunological evidence of SLE became manifest. The second sister developed classical SLE at the age of 15 years. Clinical, immunological, etiological and therapeutical aspects of SLE are being discussed.
mesh_terms: D000293:Adolescent; D000743:Anemia, Hemolytic / Q000175:diagnosis / Q000188:drug therapy; D001379:Azathioprine / Q000627:therapeutic use; D002648:Child; D004200:Diseases in Twins; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy / Q000235:genetics*; D011241:Prednisone / Q000627:therapeutic use; D011247:Pregnancy; D014430:Twins, Monozygotic
chemical_list: D001379:Azathioprine; D011241:Prednisone
vernacular_title: Zum Lupus erythematodes visceralis anhand einer Beobachtung bei Zwillingen.