[Proliferative kinetics of antibody-forming cells normally and exposed to vinblastine].
The proliferative kinetics of IgM antibody-producing cells (APC) of mice immunized by sheep red blood cells was studied using autoradiography and vinblastine. The incorporation index for APC was determined every 4 hours from 72 to 112 hours of the immune response. The significance of recruitment in APC exponential growth was proven by means of 3 different regimes of 3H-thymidine introduction to immunized mice. The discontinuous character of recruitment and its resistance to vinblastine were shown. It is suggested that vinblastine impared both APC and their precursors.
D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000502:physiology*; D001345:Autoradiography; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D007700:Kinetics; D051379:Mice; D008808:Mice, Inbred CBA; D013154:Spleen / Q000166:cytology; D013997:Time Factors; D014747:Vinblastine / Q000494:pharmacology*
D014747:Vinblastine
Issledovanie proliferativnoĭ kinetiki antiteloobrazuiushchikh kletok v norme i pri vozdeĭstvii vinblastinom.