title: Model computation of the effect of arbitrary variations in aqueous inflow, outflow conductance, ocular rigidity and episcleral vein pressure on ocular pressure.
abstract: Model calculations of the time course of the intraocular pressure are performed in cases where the four determinants mentioned in the title vary, singly or simultaneously, according to specified time functions. Assumptions are 1) that the outflow of the aqueous humor is proportional to the driving pressure, and 2) that the intraocular pressure and volume are  related to each other as described by Friedenwald. The mathematical solution if numerical and involves the repetition of the same calculatory step process. It is rendered probable that the maximal inhibitory effect of acetazolamide on the secretion  of  aqueous humour is reached in less than one minute after the drug has reached the receptors. A programmable calculator with 224 storage locations is used, the programs are given.
mesh_terms: D000086:Acetazolamide / Q000008:administration & dosage; D001082:Aqueous Humor / Q000378:metabolism / Q000502:physiology*; D003201:Computers; D007275:Injections, Intravenous; D007429:Intraocular Pressure / Q000187:drug effects; D008433:Mathematics; D008954:Models, Biological; D014690:Venous Pressure / Q000187:drug effects
chemical_list: D000086:Acetazolamide