title: Does promethazine (Atosil) influence the human's early acoustically evoked potentials in the same way as the late potential N1?
abstract: In a former investigation the effect of promethazine (Atosil) on the late acoustically evoked potential component N1 was examined. Now the cochlear and the brain-stem potentials were registered by the earlobe-vertex pick-up with i.m. application of 0.8 mg/kg (body weight) promethazine. There was no influence of promethazine either on the compound action potential (NAP) or on the brain-stem potentials (Pot. II-V), but sedation improves significantly the signal-to-noise ratio, therefore we sedate all patients when registering the five early acoustically evoked potentials.
mesh_terms: D000161:Acoustic Stimulation; D000200:Action Potentials / Q000187:drug effects; D000284:Administration, Oral; D001303:Auditory Cortex / Q000502:physiology; D001933:Brain Stem / Q000502:physiology; D003051:Cochlea / Q000502:physiology; D005071:Evoked Potentials / Q000187:drug effects*; D006801:Humans; D011398:Promethazine / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D011398:Promethazine