Circulating autoantibody against human myoglobin in polymyositis.
A passive hemagglutination method for circulating autoantibody to purified human skeletal muscle myoglobin has been developed. This antibody was detected in the sera of 22 of 31 patients with polymyositis. The incidence and the antibody titers were significantly higher than in other myopathies such as myasthenia gravis (P less than .02), Duchenne-type muscular dystrophy (P less than .001), and other conditions (P less than .001). This new antibody test is useful in diagnosing polymyositis.
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis; D003882:Dermatomyositis / Q000175:diagnosis / Q000276:immunology*; D005260:Female; D006386:Hemagglutination Tests / Q000379:methods; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D009103:Multiple Sclerosis / Q000276:immunology; D009136:Muscular Dystrophies / Q000276:immunology; D009157:Myasthenia Gravis / Q000276:immunology; D009211:Myoglobin / Q000276:immunology*; D012213:Rheumatic Fever / Q000276:immunology
D001323:Autoantibodies; D009211:Myoglobin