Examination of the role of 'non-functional' corpora lutea in the female rat.
In rats with 5 day reproductive cycles, 'anovulatory' cycles were induced by blockade of ovulation with sodium pentobarbitone injected at pro-oestrus. Such anovulatory cycles were characterized in the ovaries by gradual atresia of the large follicles present at the time of the injection and the growth of a new cohort destined for the next ovulation. In the vaginal smears, anovulatory cycles were indistinguishable from normal ovulatory cycles. The serum concentrations of progesterone remained at baseline levels during dioestrus of anovulatory cycles whereas increased concentrations of progesterone were observed during dioestrus of ovulatory cycles. It is concluded that the 'non-functional' corpora lutea of the cycle are the source of dioestrous progesterone. The length of anovulatory cycles after a single injection of pentobarbitone was 5 days despite the absence of any increase in progesterone concentrations during dioestrus. It is concluded that progesterone production during dioestrus plays no major role in the control of the duration of 5 day reproductive cycles.
D000818:Animals; D000858:Anovulation / Q000503:physiopathology*; D003338:Corpus Luteum / Q000187:drug effects / Q000502:physiology*; D004031:Diestrus / Q000187:drug effects; D005260:Female; D010060:Ovulation / Q000187:drug effects*; D010424:Pentobarbital / Q000494:pharmacology*; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D051381:Rats
D011374:Progesterone; D010424:Pentobarbital