Mouse teratomas and embryoid bodies: their induction and differentiation.
Teratomas were induced by the transfer of mouse blastocysts (C3H and 129/J strains) and egg-cylinders (C3H) to extra-uterine sites. C3H and 129/J blastocysts cultured in vitro for 4 or 5 days could also form teratomas in extra-uterine sites. Four transplantable teratomas, or teratocarcinomas, were derived from C3H embryos; embryoid bodies were derived from each line. The differentiative capacity of a teratocarcinoma was shown to be similar whether it was maintained as a solid tumour or as embryoid bodies.
D000818:Animals; D001755:Blastocyst; D002454:Cell Differentiation; D004407:Dysgerminoma / Q000209:etiology; D005260:Female; D007668:Kidney; D051379:Mice; D008809:Mice, Inbred C3H; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental; D010063:Ovum; D013724:Teratoma / Q000209:etiology* / Q000473:pathology