Gene mutation and sister chromatid exchange in Chinese hamster cells.
The mutation in hypoxanthine phosphoribosyl transferase gene and the induction of sister chromatid exchange (SCE) were comparatively studied treating Chinese hamster ovary cells with the mutagens ethylmethanesulphonate. N-methyl-N'-nitro-N-nitrosoguanidine, Mitomycin C and X-ray. All the agents exerted strong mutagenic effects and showed a dose-dependent relationship for the induction of SCEs.
D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D006224:Cricetinae; D003434:Crossing Over, Genetic; D005020:Ethyl Methanesulfonate / Q000494:pharmacology; D005260:Female; D005796:Genes; D007041:Hypoxanthine Phosphoribosyltransferase / Q000235:genetics*; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology; D008937:Mitomycins / Q000494:pharmacology; D009154:Mutation; D010053:Ovary; D012854:Sister Chromatid Exchange; D014965:X-Rays
D008937:Mitomycins; D008769:Methylnitronitrosoguanidine; D005020:Ethyl Methanesulfonate; D007041:Hypoxanthine Phosphoribosyltransferase