title: A dog model for human psychopathology.
abstract: The author reviews studies of the development and scientific exploitation of two true-breeding strains of pointer dogs, one of which is basically normal and one of which is nervous, particularly around people. Basic studies, which generally contrast the nervous dogs with the normal dogs, include studies of inheritance, early experience, conditioning, psychophysiology, neuropharmacology, and neurochemistry. The author suggests that the nervous line is an animal model of human psychopathology and probably of cardiac pathology.
mesh_terms: D000818:Animals; D001007:Anxiety / Q000235:genetics* / Q000503:physiopathology / Q000523:psychology; D001145:Arrhythmias, Cardiac / Q000503:physiopathology; D001522:Behavior, Animal; D001921:Brain / Q000503:physiopathology; D003213:Conditioning, Psychological; D004195:Disease Models, Animal; D004285:Dogs / Q000097:blood; D004777:Environment; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000494:pharmacology
chemical_list: D008774:Methylphenidate