[Detection of noise-induced physiological stress and hearing loss in guinea pigs by means of an electro-cochleographic method (author's transl)].
One of the most essential prerequisites to the suitability of test animals used for studying the damage effect of noise on audition is the threshold determination with reasonable expenditure. Mention is made of an electro-cochleographic method to determine the click threshold and click threshold shift [TTS(C) and PTS(C)], resp., after an uninjured guinea pig has been subjected to noise. The temporary threshold shift following a short-term sonic exposure and the permanent threshold shift following a permanent sonic exposure reveal a far heavier effect on the guinea pig ear than on the human ear. However, the trends in stress and affection are so much alike in guinea pig and man that the former's involvement in studying the effects of audition-affecting noise on the human ear seems to be primising.
D000222:Adaptation, Physiological; D000818:Animals; D001309:Auditory Threshold; D003051:Cochlea; D003638:Deafness / Q000175:diagnosis*; D004568:Electrodiagnosis; D005260:Female; D006168:Guinea Pigs; D006317:Hearing Loss, Noise-Induced / Q000175:diagnosis*; D006801:Humans; D008297:Male; D009622:Noise / Q000009:adverse effects*; D013312:Stress, Physiological / Q000175:diagnosis*; D013997:Time Factors
Nachweis der physiologischen Beanspruchung und der Schädigung des Meerschweinchengehörs nach Lärmeinwirkung mittels Elektrocochleographie.