[Effect of intra-duodenal administration of HCl and NaHCO3 on the secretion and content of sodium, potassium and calcium in the pancreatic juice and bile of sheep].
The experiments were carried out on 3 sheep with a Harrison type cannula inserted into the funds of the gall-bladder enabling to obtain bile and with a Herrera type cannula fixed in the duodenum enabling to sample pancreatic juice. Administration of 3 mEq HCl in 50 ml of solution to the duodenum increased the volume of secreted bile from 6,04 ml to 8,11 ml/15 min with no essential changes in the volume of pancreatic juice. Administration of 15 mEq NaHCO3 in 50 ml of solution decreased the volume of secreted bile from 6.73 ml to 4,15 ml/15 min and decreased pancreatic juice from 5,46 ml to 4.72 ml/15 min. Intravenous administration of secret increased the volume of both pancreatic juice and bile. Administration of HCl and NaHCO3 solution to the duodenum did not cause changes in the concentration and secretion of sodium, potassium and calcium in pancreatic juice and bile. The results point to the predominance of the secretory function of bile over pancreatic juice in sheep after stimulation of the duodenum with the investigated substances.
D000818:Animals; D001639:Bicarbonates / Q000008:administration & dosage; D001646:Bile / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004386:Duodenum; D006851:Hydrochloric Acid / Q000008:administration & dosage; D007440:Intubation; D010189:Pancreatic Juice / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism*; D012756:Sheep / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism*
D001639:Bicarbonates; D012964:Sodium; D006851:Hydrochloric Acid; D011188:Potassium; D002118:Calcium
Wpływ dodwunastniczego podawania HCl i NaHCO3 na wydzielanie i zawartość sodu, potasu i wapnia w soku trzustkowym i zółci u owiec.