title: Pc 1 Duarte, a common polymorphism of a human brain protein, and its relationship to depressive disease and multiple sclerosis.
abstract: Pc 1 Duarte, a common variant of a human brain-specific protein, is present in one-third of the control population and has a gene frequency of 0.17. There was a significantly increased frequency of mutant heterozygotes and homozygotes among individuals with depressive disease. This is consistent with a model in which Pc 1 Duarte is the major gene in depressive disease, acting in conjunction with an environmental threshold effect.
mesh_terms: D044383:Black People; D002421:Caudate Nucleus / Q000378:metabolism; D003866:Depressive Disorder / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000235:genetics*; D009419:Nerve Tissue Proteins / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic; D011699:Putamen / Q000378:metabolism; D013405:Suicide; D044465:White People
chemical_list: D009419:Nerve Tissue Proteins