Oral nicotinic acid as a treatment for ketosis.
Changes in blood metabolites and milk production were measured in eight cows with subclinical or clinical ketosis following treatment with daily doses of 12 g nicotinic acid fed with the concentrate mixture. Ketotic cows displayed a positive milk ketone test, reduced milk production and feed intake, hypoglycemia, hyperketonemia, and elevated free fatty acids in plasma. The milk ketone test was negative in all cows 5 to 9 days following initiation of treatment. After 7 days of treatment, milk production and glucose in plasma were increased while there were decreases in plasma beta-hydroxybutyrate and free fatty acids. No relapses occurred.
D000138:Acidosis / Q000662:veterinary*; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D006885:Hydroxybutyrates / Q000097:blood; D007662:Ketosis / Q000188:drug therapy / Q000662:veterinary*; D007774:Lactation; D008892:Milk / Q000032:analysis; D009539:Nicotinic Acids / Q000627:therapeutic use*; D011247:Pregnancy
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D006885:Hydroxybutyrates; D009539:Nicotinic Acids