Impaired secretin release in chronic alcoholic dogs.
Plasma immunoreactive secretin has been compared before and after stimulation by intraduodenal infusion of HCl in 3 dogs who had received 2 g-kg-1-day-1 alcohol for 3 years and 4 non-alcoholic control dogs. After HCl infusion, blood secretin was lower in chronic alcoholic animals than in controls. This decreased post-stimulation concentration of secretin in chronic alcoholic dogs was in contrast to the increased release of gastrin after a meal which has been previously described.
D000437:Alcoholism / Q000503:physiopathology*; D000818:Animals; D004285:Dogs; D004386:Duodenum; D006801:Humans; D006851:Hydrochloric Acid / Q000008:administration & dosage; D007441:Intubation, Gastrointestinal; D012633:Secretin / Q000097:blood / Q000378:metabolism*; D013268:Stimulation, Chemical
D012633:Secretin; D006851:Hydrochloric Acid