Familial Y/22 translocation in a woman.
A phenotypically normal 35-year-old woman who had a malformed fetus was found to have a Y/22 translocation. One brother as well as a sister and her three children also have the Y/22 chromosome while another sister lacks it. The problem raised by the presence of this translocated chromosome for genetic counseling, especially for prenatal diagnosis, is emphasized.
D000328:Adult; D002871:Chromosome Banding; D002904:Chromosomes, Human, 21-22 and Y; D005260:Female; D005817:Genetic Counseling; D006801:Humans; D007621:Karyotyping; D008297:Male; D010375:Pedigree; D010641:Phenotype; D011796:Quinacrine; D012730:Sex Chromosomes; D014178:Translocation, Genetic; D014998:Y Chromosome
D011796:Quinacrine