Synthesis and chemical properties of N- and O-phosphorylated derivatives of creatinol.
N-Methyl-N-(beta-hydroxyethyl)-guanidine O-phosphate (creatinol O-phosphate) was synthesized from creatinol by phosphorylation with partially hydrolyzed phosphoryl chloride or by dehydration of its phosphate salt. Creatinol N-phosphate was obtained by addition of N-methylamino ethanol to bis-p-nitrobenzylphosphocyanamide, followed by hydrogenolysis. The chemical properties of both compounds were investigated; creatinol N-phosphate was rearranged to creatinol O-phosphate by heating.
D055598:Chemical Phenomena; D002621:Chemistry; D003401:Creatine / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D006868:Hydrolysis; D013997:Time Factors
C100173:creatinol phosphate; D003401:Creatine