Antimycobacterial activity of some potential chemotherapeutic compounds.
Fourteen compounds were tested in vitro for activity against Mycobacterium intracellulare and other pathogenic mycobacteria. Only clofazimine and chaulmoogric acid showed significant activity against M. intracellulare. In view of known minimal side effects of clofazimine further studies are warranted for this drug in chemotherapy of M. intracellulare infections.
D002991:Clofazimine / Q000494:pharmacology* / Q000627:therapeutic use; D003517:Cyclopentanes / Q000494:pharmacology; D005227:Fatty Acids / Q000494:pharmacology; D009161:Mycobacterium / Q000187:drug effects*; D009164:Mycobacterium Infections / Q000188:drug therapy; D009821:Oils / Q000494:pharmacology*
D003517:Cyclopentanes; D005227:Fatty Acids; D009821:Oils; C017119:chaulmoogric acid; D002991:Clofazimine