Neonatal hypocalcaemia associated with maternal hyperparathyroidism. New pathogenetic observations.
A 32-day-old male infant had hypocalcaemic convulsions associated with asymptomatic maternal hyperparathyroidism. Very low total and ionised serum calcium, increased serum phosphate, and normal serum parathyroid hormone (PTH) and 25-hydroxycholecalciferol (25-OHD3) concentrations were found at admission. After treatment with calcium and vitamin D, serum PTH and 25-OHD3 concentrations increased markedly before serum calcium levels returned to normal perhaps indicating an inability to convert 25-OHD3 to the metabolically active 1,25-dihyroxyvitamin D3 during the hyperphosphataemic state. Treatment with 1,25-dihdroxyvitamin D3 or its analogues is recommended.
D002118:Calcium / Q000097:blood / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism; D006996:Hypocalcemia / Q000188:drug therapy / Q000209:etiology*; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications; D012640:Seizures / Q000209:etiology; D014807:Vitamin D / Q000627:therapeutic use
D014807:Vitamin D; D002118:Calcium