[Assembly and function of organized enzymes (author's transl)].
When different enzymes form complexes with one another they gain new capabilities of function. Tryptophan synthase is discussed as an illustrative example in which formation of the complex leads to mutual activation of the component subunits. Kinetic studies show that conformational changes play an important role in this process. As the extreme case of self-organisation, structural genes of different enzymes might have been fused in the course of evolution, giving rise to multifunctional enzymes.
D005075:Biological Evolution; D004789:Enzyme Activation; D005796:Genes; D009097:Multienzyme Complexes / Q000378:metabolism*; D011487:Protein Conformation; D014367:Tryptophan Synthase / Q000378:metabolism
D009097:Multienzyme Complexes; D014367:Tryptophan Synthase
Assembly und Funktion organisierter Enzyme