title: [Primary and secondary immune response in animals following spontaneous loss of tolerance].
abstract: Mice subjected to tolerogenic treatment by sheep red blood cells (SRBC) and cyclophosphamide were immunized at various intervals (from 1 to 8 weeks after treatment) either by a single injection of 5 X 10(8) SRBC or by a double-injection of 1 X 10(6) SRBC. In control mice both immunization methods proved to be equally successful. In the experimental animals the immunological memory formation and/or its realization was destroyed to a greater extent and was restored more slowly than the capacity to the primary response.
mesh_terms: D000818:Animals; D000917:Antibody Formation; D000921:Antibody-Producing Cells; D003520:Cyclophosphamide / Q000494:pharmacology; D006824:Hybridization, Genetic; D007108:Immune Tolerance; D007156:Immunologic Memory; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013154:Spleen / Q000276:immunology
chemical_list: D003520:Cyclophosphamide
vernacular_title: Izuchenie pervichnogo i vtorichnogo immunnogo otveta u zhivotnykh posle spontannoĭ utraty tolerantnosti.