[Biopharmaceutic investigations with D-norpseudoephedrine. 2nd communication: Bioavaliability of a depot preparation (author's transl)].
The concentrations of D-norpseudoephedrine in the plasma of five healthy male subjects were measured after oral administration of either two Fugoa depot aragees or of a standard of 60 mg D-norpseudoephedrinehydrochloride in a hard gelatin capsule. Areas under curves (AUC) were calculated with the trapezoidal-rule for blood levels to compare bioavailability. The medium bioavailability of Fugoa depot dragees was 95% compared to the standard. With the paired t-test no significant difference in the bioavailability occurred.
D001702:Biopharmaceutics; D003692:Delayed-Action Preparations; D004809:Ephedrine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D006801:Humans; D008297:Male
D003692:Delayed-Action Preparations; D004809:Ephedrine
Biopharmazeutische Untersuchungen an D-Norpseudoephedrin 2. Mitt: Bioverfügbarketi aus einer Depot-Zubereitung