Aspirin- and bile- induced acute erosive gastritis: its prevention by metiamide therapy.
Aspirin or bile administered by esophageal intubation to rats produced acute gastric erosions. These injuries could have been prevented by the prior administration by esophageal intubation of metiamide, a histamine H2 receptor antagonist that is known to inhibit gastric acid secretion.
D000208:Acute Disease; D000818:Animals; D001241:Aspirin / Q000009:adverse effects*; D001647:Bile Acids and Salts / Q000009:adverse effects*; D005753:Gastric Mucosa / Q000473:pathology*; D005756:Gastritis / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control; D008297:Male; D008785:Metiamide / Q000627:therapeutic use*; D051381:Rats; D013890:Thiourea / Q000031:analogs & derivatives*
D001647:Bile Acids and Salts; D008785:Metiamide; D013890:Thiourea; D001241:Aspirin