Morphological lesions in guinea pigs during skin exposure to 1,1,2-trichloroethane.
Guinea pigs were exposed to 1,1,2-trichloroethane applied directly on the skin of the back for periods between 15 minutes and twelve hours under anaesthesia. Morphological changes could be observed in the epidermis after 15 minutes and continued to progress during continuing exposure. The changes consisted of pyknotic nuclei, perinuclear  oedema of basal and suprabasilar cells as well as a focal separation of the epidermis from the corium with vesicle formations. The liver tissue showed reduction of glycogen content as well as hydropic changes  in the centrilobular areas six hours after the start of exposure. The liver changes were less marked 12 hours after exposure and absent in nonanaesthetized animals. No morphological changes were observed in the kidney or the brain.
D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology; D005260:Female; D006168:Guinea Pigs; D006843:Hydrocarbons, Chlorinated / Q000633:toxicity*; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D012867:Skin / Q000187:drug effects / Q000473:pathology; D012871:Skin Diseases / Q000139:chemically induced* / Q000473:pathology; D013997:Time Factors; D014240:Trichloroethanes / Q000633:toxicity*
D006843:Hydrocarbons, Chlorinated; D008112:Liver Glycogen; D014240:Trichloroethanes