[Effect of the diuretic Etozolin (Gö 687) on renal elimination of water and solutes in subjects with normal renal function (author's transl)].
The novel diuretic ethyl (Z)-(3-methyl-4-oxo-5-piperidino-thiazolidin-2-ylidene)acetate (etozolin, Gö 687, Elkapin) has been investigated on 10 volunteers with intact renal function. Administration of 800 mg of the compound caused a significant increase of the renal elimination of water, sodium, chloride magnesium as well as of the sum of the osmotic constituents while an influence on the creatinine-clearance could not be demonstrated. Potassium elimination was also raised, however, at the same time the sodium-potassium ration increased strongly. Due to its long-lasting action etozolin seems particularly indicated for the treatment of cardiac and renal edema as well as for the treatment of hypertension.
D000328:Adult; D001834:Body Water / Q000378:metabolism*; D002712:Chlorides / Q000652:urine; D003404:Creatinine / Q000652:urine; D004232:Diuretics / Q000494:pharmacology*; D006801:Humans; D007668:Kidney / Q000502:physiology*; D008274:Magnesium / Q000652:urine; D008297:Male; D010880:Piperidines / Q000494:pharmacology; D011188:Potassium / Q000652:urine; D013844:Thiazoles / Q000494:pharmacology*; D014882:Water-Electrolyte Balance / Q000187:drug effects*
D002712:Chlorides; D004232:Diuretics; D010880:Piperidines; D013844:Thiazoles; D003404:Creatinine; D008274:Magnesium; D011188:Potassium
Wirkung des Diuretikums Etozolin (Gö 687) auf die renale Ausscheidung von Wasser und Soluta bei normaler Nierenfunktion.