The effect of synthetic scotophobin on motor activity in mice.
The motor activity of mice treated by scotophobin (1, 2, 4, 6 micrograms) was tested in a photoresistor actometer 24, 48 and 72 h after injection. Scotophobin in doses of 4 and 6 micrograms per mouse increased significantly the motor activity as compared with controls injected with saline only. This result suggests that shortening of dark box time, found by some authors after injection of scotophobin, seem to be the consequence of the enhanced motor activity of mice. Thus the effect of scotophobin on the behavior of animals is not specific and this substance can not be considered responsible for the "memory transfer".
D000818:Animals; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D010455:Peptides / Q000009:adverse effects / Q000494:pharmacology*
D010455:Peptides