[Immunotropic activity of adapiprazine].
It is shown that the replacement of the ethyl or methyl radical in the molecules of aethaperazine or metherazine with the adamantyl one results in the appearance of a singular immunotropic activity. Such a drug (adapiprazine) exerts an immunodepressive action both on the primary and secondary response of the mice immunized with sheep erythrocytes. The immunodepressive action of adapiprazine is manifest with a low-dosage optimum introduced before immunization. In analogous conditions aethaperazine and metherazine fail to display any immunodepressive action. Adapiprazine arrests the rejection of a skin allotrasplant in mice differing from the donors in the presence of a strong histocompatibility locus. In in vitro tests adapiprazine in a concentration of 10(-5) mol and less has no effect on the spontaneous migration of leucocytes in the capillary, nor upon the process of immune roset-formation.
D000218:Adamantane / Q000031:analogs & derivatives / Q000276:immunology / Q000633:toxicity; D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects; D004306:Dose-Response Relationship, Immunologic; D004912:Erythrocytes / Q000276:immunology; D006801:Humans; D006824:Hybridization, Genetic; D007109:Immunity / Q000187:drug effects; D007114:Immunization; D007166:Immunosuppressive Agents; D066298:In Vitro Techniques; D007700:Kinetics; D007962:Leukocytes / Q000276:immunology; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D010546:Perphenazine / Q000276:immunology; D010640:Phenothiazines / Q000276:immunology* / Q000633:toxicity; D011346:Prochlorperazine / Q000276:immunology; D012397:Rosette Formation; D013997:Time Factors
D007166:Immunosuppressive Agents; D010640:Phenothiazines; C015648:adapiprazine; D010546:Perphenazine; D000218:Adamantane; D011346:Prochlorperazine
Immunotropnaia aktivnost' adapiprazina.