Nitrones. 7. alpha-Quinoxalinyl-N-substituted nitrone 1,4-dioxides.
A series of alpha-quinoxalinyl-N-substitute nitrone 1,4-dioxides has been synthesize and evaluated as antibacterial and antiprotozoal agents. Structure-activity relationships are discussed. Of the compounds tested, alpha-(3-methyl-2-quinoxalinyl)-N-methylnitrone 1,4-dioxide (2) was the most active agent in vivo against the gram-negative and the gram-positive organisms.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D000981:Antiprotozoal Agents / Q000138:chemical synthesis*; D001419:Bacteria / Q000187:drug effects; D007928:Lethal Dose 50; D008722:Methods; D051379:Mice; D011528:Protozoan Infections / Q000188:drug therapy; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D013329:Structure-Activity Relationship; D014422:Turkeys
D000900:Anti-Bacterial Agents; D000981:Antiprotozoal Agents; D011810:Quinoxalines