The role of some prostaglandins in the interaction of fibrinogen degradation products (FDP) with central dopamine receptors of rats.
Indomethacin and fibrinogen degradation products (FDP) augmented amphetamine and apomorphine-induced stereotypies. In contrast, PGE1 and PGE2 decreased the stereotypies in rats, while PGF2 alpha enhanced amphetamine-induced stereotypy. Indomethacin given in combination with the peptides did not change their effect, whereas prostaglandins diminished the stimulatory effect of FDP on the amphetamine or apomorphine-induced stereotypy. Indomethacin and studied prostaglandins did not influence inhibitory action of FDP on haloperidol-induced catalepsy. It is concluded that prostaglandins do not play any essential role in the interaction of FDP with dopaminergic system in the CNS.
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D002375:Catalepsy / Q000139:chemically induced; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism*; D006801:Humans; D008297:Male; D011453:Prostaglandins / Q000502:physiology*; D051381:Rats; D011954:Receptors, Dopamine / Q000378:metabolism*; D013239:Stereotyped Behavior / Q000187:drug effects; D013997:Time Factors
D005338:Fibrin Fibrinogen Degradation Products; D011453:Prostaglandins; D011954:Receptors, Dopamine; D000661:Amphetamine; D001058:Apomorphine