Rat dopamine hypersensitivity. I. Effect of age.
Two groups of 5 Sprague-Dawley rats were tested with either d-amphetamine or saline following our drug abuse-kindling model for dopaminergic hypersensitivity on pretest and posttest. However, when the animals were 40 weeks older, the saline group also received d-amphetamine. Thus, this group served as saline control for the initial two tests and-amphetamine control for age on the third session. The control group showed significantly more stereotyped behavior on Phase 3 as compared with the experimental group in the first session. These results suggest an increased responsivity of dopaminergic receptors with age as measured by stereotyped behavior in rats.
D000367:Age Factors; D000818:Animals; D003913:Dextroamphetamine; D004342:Drug Hypersensitivity / Q000503:physiopathology*; D006801:Humans; D008297:Male; D051381:Rats; D011954:Receptors, Dopamine / Q000502:physiology*; D013239:Stereotyped Behavior; D019966:Substance-Related Disorders / Q000503:physiopathology
D011954:Receptors, Dopamine; D003913:Dextroamphetamine