Sustained release methadone salts and methadone-naloxone mixtures. Part 2: In vitro studies of methadone release.
Various tablet formulations, using two methadone salts namely methadone-alpha-naphthalenesulfonate and methadone-o-benzoylbenzoate and a number of methadone-naloxone combinations were prepared. The quantities of methadone released from these tablets in simulated gastric and intestinal fluids were examined using spectrophoto-metric studies. All formulations followed a typical release pattern, indicating a high degree of consistency of the formulations.
D003692:Delayed-Action Preparations; D005750:Gastric Juice / Q000378:metabolism; D006556:Heroin Dependence / Q000188:drug therapy / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D008691:Methadone / Q000378:metabolism / Q000627:therapeutic use*; D009270:Naloxone / Q000378:metabolism / Q000627:therapeutic use*
D003692:Delayed-Action Preparations; D009270:Naloxone; D008691:Methadone