title: [Genetic aspects of the effect of Vi-antigen deposition in the human body. I. Hereditary cause of the effect of Vi-antigen deposition on erythrocytes].
abstract: Investigation of the minimal and the optimal capasity of the Vi-antigen sorption in erythrocytes was carried out in partners of 11 pairs of monozygotic and 8 pairs of dizygotic twins. It is shown that the capacity of erythrocytes to sorb Vi-antigen in minimal concentrations (Smin) is under relatively rigid genetic control (G = 0.84), while the capacity of its sorption in optimal doses (Sopt) is to a much greater extent subjected to paratypic effects (G = 0.40). It is assumed that Smin is controlled by the system of the "main" gene, while Sopt is determined multifactorially, which affords the possibilities of creating adequate conditions for the vaccination of a concrete individual.
mesh_terms: D000942:Antigens, Bacterial / Q000235:genetics*; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D005838:Genotype; D006382:Hemadsorption; D006386:Hemagglutination Tests; D006801:Humans; D011247:Pregnancy; D014429:Twins, Dizygotic; D014430:Twins, Monozygotic
chemical_list: D000942:Antigens, Bacterial
vernacular_title: Geneticheskie aspekty éffekta deponirovaniia Vi-antigens v organizme cheloveka. Soobshchenie I. Nasledstvennaia obuslovlennost' éffekta deponirovaniia Vi-antigena na éritrotsitakh.