Effect of prostaglandin A1 infusion in hypertensive patients with renal artery stenosis.
Clinical data, arteriographic findings, peripheral and renal vein plasma renin activity (PRA) studies and responses to prostaglandin A1 infusion are presented from observations in seven hypertensive patients with renal artery stenosis. PGA1 infusion caused an increase in PRA and urine sodium excretion but no significant change in blood pressure. Exaggerated increases in PRA were observed in five patients. With cessation of PGA1 infusion PRA returned toward pre-infusion levels. In two patients bilateral renal and peripheral vein PRA's were determined before and during PGA1 infusion. PGA1 caused a greater increase in renal vein PRA than in peripheral vein PRA indicating a direct enhancement of renin secretion. These studies indicate possible relationships between the vasoactive prostaglandins and the renin-angiotensin system in the pathogenesis of hypertension due to renal artery stenosis.
D000328:Adult; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D007668:Kidney / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011454:Prostaglandins A / Q000494:pharmacology*; D012078:Renal Artery Obstruction / Q000503:physiopathology*; D012083:Renin / Q000097:blood / Q000378:metabolism*; D012964:Sodium / Q000652:urine
D011454:Prostaglandins A; D012964:Sodium; D012083:Renin