Effect of phenacetin and N-alkylacetanilides on N-2-fluorenylacetamide hepatocarcinogenesis.
Phenacetin, N-methylacetanilide and N-ethylacetanilide prevented N-2-fluorenylacetamide hepatocarcinogenesis in F344 strain rats. Phenacetin was most effective followed by N-ethylacetanilide. Phenacetin was not carcinogenic when fed at 0.8% level for 16 weeks followed by control diet for another 10 weeks.
D015073:2-Acetylaminofluorene / Q000633:toxicity*; D000083:Acetanilides / Q000494:pharmacology*; D000818:Animals; D008113:Liver Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control; D010615:Phenacetin / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats
D000083:Acetanilides; C030135:N-ethylacetanilide; C030136:N-methylacetanilide; D015073:2-Acetylaminofluorene; D010615:Phenacetin