Interaction of molybdenum with other elements and compounds in the organism.
The toxic effect of molybdenum lies in the inhibition of the activity of the sulphide oxidase system and in the formation of thiomolybdate from molybdate and endogenous sulphides. Sulphate ions activate the enzymic system oxidizing sulphide and thiomolybdate thus restraining the formation of thiomolybdate and accelerating the oxidation of thiomolybdate to the less toxic molybdate.
D000818:Animals; D003300:Copper / Q000378:metabolism / Q000494:pharmacology; D004032:Diet; D004044:Dietary Proteins; D006801:Humans; D008099:Liver / Q000201:enzymology; D008982:Molybdenum / Q000378:metabolism* / Q000633:toxicity; D050862:Oxidoreductases Acting on Sulfur Group Donors / Q000378:metabolism; D051381:Rats; D013431:Sulfates / Q000494:pharmacology
D004044:Dietary Proteins; D013431:Sulfates; D003300:Copper; D008982:Molybdenum; D050862:Oxidoreductases Acting on Sulfur Group Donors