[Effect of chronic alcoholic intoxication on the circadian rhythm of the hypothalamic neurosecretory centers in rats].
Experiments were conducted on male rats; by means of quantitative cytochemical analysis and karyometry circadian rhythm of the hypothalamo-hypophysial neurosecretory system function was studied. In the evening (9--10 p.m.) the intensity of the synthesis, transport, and neurosecretion showed a significant elevation in comparison with the day (3--4 p.m.). Neurosecretory process was suppressed and the circadian rhythm of the hypothalamic neurosecretory system activity was disturbed in rats given a 5% ethanol solution as the only source of fluid for 2 months. As suggested, damage of an important biorhythm synchronizer (the neurosecretory centers of the hypothalamus) could play an important role in the pathogenesis of chronic alcoholism.
D000437:Alcoholism / Q000503:physiopathology*; D000818:Animals; D002940:Circadian Rhythm / Q000187:drug effects*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects; D007031:Hypothalamus / Q000187:drug effects*; D008297:Male; D009490:Neurosecretory Systems / Q000187:drug effects*; D010286:Paraventricular Hypothalamic Nucleus / Q000187:drug effects; D051381:Rats; D013495:Supraoptic Nucleus / Q000187:drug effects; D013997:Time Factors
Vliianie khronicheskoĭ alkogolnoĭ intoksikatsii na tsirkadnyĭ ritmneĭrosekretornykh tsentrov gipotalamusa krys.