title: Protective effect of creatinol O-phosphate (COP) on some experimental arrhythmias in vitro and in vivo.
abstract: The activity of N-methyl-N-(beta-hydroxyethyl)guanidine O-phosphate (creatinol O-phosphate, COP) on two in vitro and in vivo experimental arrhythmias was investigated. The substance proved to be active in delaying the onset time of aconitine induced arrhythmias in guinea-pig atria. COP showed also a definite antagonizing activity against chloroform-induced ventricular fibrillation in mice.
mesh_terms: D000157:Aconitine; D000818:Animals; D000889:Anti-Arrhythmia Agents; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000517:prevention & control; D002725:Chloroform; D003401:Creatine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006168:Guinea Pigs; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D011299:Prenylamine / Q000494:pharmacology; D011802:Quinidine / Q000494:pharmacology; D014693:Ventricular Fibrillation / Q000139:chemically induced / Q000517:prevention & control
chemical_list: D000889:Anti-Arrhythmia Agents; C100173:creatinol phosphate; D002725:Chloroform; D011802:Quinidine; D011299:Prenylamine; D003401:Creatine; D000157:Aconitine