Regulation of protein synthesis, intracellular electrolytes and cataract formation in vitro.
Control of protein synthesis is associated with changes in the ratio of intracellular Na+ to K+ in the cultured embryonic chick lens. Correlations of intracellular Na+/K+ ratios with crystallin synthesis and cataract formation in vitro suggest that the Na+/K+ ratio may have an important role in the regulation of protein synthesis during cataractogenesis.
D000818:Animals; D002386:Cataract / Q000209:etiology*; D002642:Chick Embryo; D003459:Crystallins / Q000096:biosynthesis*; D046508:Culture Techniques; D007908:Lens, Crystalline / Q000378:metabolism*; D008970:Molecular Weight; D010042:Ouabain / Q000494:pharmacology; D011188:Potassium / Q000378:metabolism*; D011817:Rabbits; D012964:Sodium / Q000378:metabolism*
D003459:Crystallins; D010042:Ouabain; D012964:Sodium; D011188:Potassium