[Changes in the metabolism of cerebral mitochondria under the influence of sera from schizophrenic patients and their relatives].
With the aid of a polarographic method it was demonstrated that the blood serum of schizophrenic patients and their relatives, unlike the blood serum taken from normal donors evoke a significant change of the metabolism in the mitochondria of the hemispheric cortex. The intensity of oxidation and respiration control under the influence of these sera change similarly, while the intensity of phosphorylation and oxidation with phosphorylation coupling change significantly to a higher degree under the influence of the blood of probands. Changes in the metabolism indices of mitochondria under the influence of these sera to a significant extent are genetically determined.
D000818:Animals; D002415:Cats; D002540:Cerebral Cortex / Q000648:ultrastructure*; D004200:Diseases in Twins; D005260:Female; D006801:Humans; D007106:Immune Sera / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D008928:Mitochondria / Q000378:metabolism*; D010101:Oxygen Consumption; D010750:Phosphoproteins / Q000378:metabolism; D011247:Pregnancy; D012559:Schizophrenia / Q000097:blood / Q000235:genetics*; D014429:Twins, Dizygotic; D014430:Twins, Monozygotic
D007106:Immune Sera; D010750:Phosphoproteins
Osobennosti izmeneniia metabolizma mitokhondriĭ mozga pod vliianiem syvorotki krovi bol'nykh shizofrenieĭ i ikh rodstvennikov.