[Effect of thiamine on the formation of immune response in toxic lesions of the liver].
The authors studied the influence of various doses of thiamine on the formation of immune response in the animals with toxic affection of the liver. As revealed, thiamine in a dose of 400 microgram per kg of body weight inhibited the formation of the immune response in healthy rats, but failed to influence this process in the animals with toxic affection of the liver. Thiamine in a dose of 100 microgram per 100 g of body weight stimulated the formation of the immune response in healthy rats and in those poisoned with carbon tetrachloride. The simulating effect of thiamine was more pronounced in poisoned than in healthy rats. The blood serum of rats poisoned with carbon tetrachloride enhanced the immunostimulating action of thiamine.
D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects; D002252:Carbon Tetrachloride Poisoning / Q000276:immunology*; D056486:Chemical and Drug Induced Liver Injury / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D051381:Rats; D012397:Rosette Formation; D013831:Thiamine / Q000008:administration & dosage / Q000276:immunology*
D013831:Thiamine
O vliianii tiamina na formirovanie immunnogo otveta pri toksicheskom porazhenii pecheni.