Enduring changes in dopamine receptor cells of pups from drug administration to pregnant and nursing rats.
A decrease in specific [3H]spiroperidol binding to rat caudate tissue and a parallel decrease in sensitivity to apomorphine in eliciting stereotyped behavior was observed in the offspring of rat mothers treated with either haloperidol or alpha-methyl-p-tyrosine-methyl ester during pregnancy. In contrast, evidence of increased dopamine-receptor sensitivity was observed in the pups if haloperidol was administered to their mothers postpartum during nursing rather than during pregnancy.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003342:Corpus Striatum / Q000187:drug effects* / Q000196:embryology / Q000254:growth & development; D005260:Female; D005333:Fetus / Q000187:drug effects*; D006220:Haloperidol / Q000494:pharmacology*; D006801:Humans; D007774:Lactation; D008431:Maternal-Fetal Exchange; D008781:Methyltyrosines / Q000494:pharmacology*; D011247:Pregnancy; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects*; D013239:Stereotyped Behavior / Q000187:drug effects
D008781:Methyltyrosines; D011954:Receptors, Dopamine; D006220:Haloperidol