[Spontaneous tumors in aged SD-JCL rats (author's transl)].
Incidence of spontaneous tumors was examined in 77 male and 73 female SD-JCL rats reared throughout their lifespan of 5 to 36 months. Total tumor incidences were 60% and 95% for males and females, respectively. The sex difference was mostly attributable to a high incidence of mammary tumor in females. The pituitary tumor was found in 30% of males and 66% of females aged 5 to 36 months while islet cell tumor of the pancreas and thyroid tumor occurred later and the incidence of latter was particularly high in rats lived more than 2 years. Myeloid leukemia appeared to occur as early as 5 months of age.
D000230:Adenocarcinoma / Q000662:veterinary; D000232:Adenofibroma / Q000662:veterinary; D000236:Adenoma / Q000662:veterinary; D000310:Adrenal Gland Neoplasms / Q000662:veterinary; D000375:Aging; D000818:Animals; D005260:Female; D005350:Fibroma / Q000662:veterinary; D008297:Male; D008321:Mammary Glands, Animal; D009369:Neoplasms / Q000453:epidemiology / Q000662:veterinary*; D010190:Pancreatic Neoplasms / Q000662:veterinary; D010911:Pituitary Neoplasms / Q000662:veterinary; D051381:Rats; D012376:Rodent Diseases / Q000453:epidemiology*; D012509:Sarcoma / Q000662:veterinary; D013964:Thyroid Neoplasms / Q000662:veterinary