Fatal complication of intravesical formalin during control of intractable hemorrhage from radiation cystitis.
Fatal acute tubular necrosis occurred in 1 patient in whom intravesical formalin was used to control massive persistent hemorrhage from radiation cystitis. A suggestion is made to monitor blood formic acid levels and institute prompt dialysis whenever these exceed 80 mg. per 100 ml. to avert such a catastrophe. Intravenous sodium bicarbonate appears to be indicated prophylactically in combating the associated metabolic acidosis due to absorbed formic acid.
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000328:Adult; D003556:Cystitis / Q000150:complications; D005557:Formaldehyde / Q000009:adverse effects* / Q000378:metabolism / Q000627:therapeutic use; D006470:Hemorrhage / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007267:Injections; D007683:Kidney Tubular Necrosis, Acute / Q000139:chemically induced*; D008297:Male; D011832:Radiation Injuries; D001743:Urinary Bladder; D001745:Urinary Bladder Diseases / Q000188:drug therapy* / Q000209:etiology
D005557:Formaldehyde