[Mechanism of action of heparin on lymphoid cells in vitro].
Heparin ability to interfere significantly with the passage of antibodies from the antibody-forming cells was shown in vitro on CBA/C mice, using a 2 percent erythrocyte suspension as an antigen. A partial restoration of the plaque formation ability was observed in vitro by the supplement of substances possessing the features of "Triton" X-100 detergents, deoxycholate to the suspension of spleen plaque forming cells treated with heparin. Hence, it was concluded that heparin was capable of interacting with the outer membrane of immunocompetent cells inhibiting the passage of synthesized antibodies to the milieu.
D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects; D003840:Deoxycholic Acid / Q000494:pharmacology; D004347:Drug Interactions; D006493:Heparin / Q000494:pharmacology*; D008214:Lymphocytes / Q000187:drug effects*; D051379:Mice; D008808:Mice, Inbred CBA; D011092:Polyethylene Glycols / Q000494:pharmacology; D013154:Spleen / Q000166:cytology / Q000276:immunology
D003840:Deoxycholic Acid; D011092:Polyethylene Glycols; D006493:Heparin
O mekhanizme deĭstviia geparina na limfoidnye kletki in vitro.