title: Effects of geophagia (kaolin ingestion) on the maternal blood and embryonic development in the pregnant rat.
abstract: Geophagia, in the form of clay-eating, is often observed during pregnancy in the human population. The intent of this study was to determine the effects of kaolin (clay) ingestion on the maternal blood and embryonic development of the pregnant rat. Thirty-six Sprague-dawley female rats were divided into three groups: control diet, 20% kaolin diet, and iron-supplemented 20% kaolin diet. The diets were fed 37 to 68 days, 69 to 95 days, and 96 to 117 days prior to fertilization, and the same diets were fed for the duration of the gestation period. The rats fed the kaolin diet exhibited significant reductions in hemoglobin, hematocrit, and red blood cell levels, thus indicating maternal anemia. There was also a significant reduction in the birth weight of the pups born to kaolin fed rats. The kaolin fed rats receiving an iron supplement maintained hematocrit, hemoglobin, red blood cell levels, and pup weight within the normal range.
mesh_terms: D000818:Animals; D001724:Birth Weight; D004906:Erythrocyte Count; D005260:Female; D006400:Hematocrit; D006801:Humans; D007501:Iron / Q000627:therapeutic use; D007616:Kaolin / Q000633:toxicity*; D008098:Litter Size; D010842:Pica / Q000150:complications*; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood / Q000188:drug therapy / Q000209:etiology*; D051381:Rats
chemical_list: D007616:Kaolin; D007501:Iron