The carcinogenicity of N-nitroso compounds formed endogenously in mice from benzimidazole carbamate pesticides.
Malignant lymphomas were developed in Swiss mice after intragastric treatment with carbamate pesticides combined with sodium nitrite in their drinking water. Attention is directed to the carcinogenic effect of N-nitroso compounds formed from carbamate pesticides in vivo. The importance of further investigations is stressed, since these results indicate that, under appropriate conditions, commercially available pesticides may increase tumor frequency in mice.
D000818:Animals; D001542:Benomyl / Q000633:toxicity*; D001562:Benzimidazoles / Q000633:toxicity*; D002219:Carbamates / Q000633:toxicity*; D005659:Fungicides, Industrial / Q000633:toxicity*; D008228:Lymphoma, Non-Hodgkin / Q000139:chemically induced*; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009573:Nitrites; D009602:Nitrosamines / Q000378:metabolism / Q000633:toxicity*; D013953:Thymus Neoplasms / Q000139:chemically induced*
D001562:Benzimidazoles; D002219:Carbamates; D005659:Fungicides, Industrial; D009573:Nitrites; D009602:Nitrosamines; D001542:Benomyl