[Influence of intrauterine hypoxia on protein synthesis in different regions of the brain and on functioning of the histo-hematic barrier during late ontogenesis in rats].
Experiments were conducted on sexually mature rats subjected to acute hypoxia at a definite antenatal period. The penetration of six labeled amino acids into the tissue of different regions of the brain and their incorporation into proteins was studied. Inhibition of protein synthesis especially in the hypothalamus and the cerebral cortex was characteristic of the experimental animals; these findings correlated with disturbances of the conditioned reflex activity. Dysfunction of the blood-brain barrier for labeled amino acids and radioactive phosphorus was found in the experimental animals; as to the permeability of other histohematic barriers -- it was unchanged.
D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D001812:Blood-Brain Barrier; D001921:Brain / Q000378:metabolism*; D005260:Female; D005311:Fetal Hypoxia / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D010710:Phosphates / Q000378:metabolism; D011247:Pregnancy; D051381:Rats
D000596:Amino Acids; D009419:Nerve Tissue Proteins; D010710:Phosphates
Vliianie vnutriutrobnoĭ gipoksii na sintez belka v raznykh otdelakh mozga i funktsiiu gisto-gematicheskikh bar'erov v pozdnem ontogeneze u krys.