[Anticoagulant activity of triiodinated x-ray opaque media (author's transl)].
The anticoagulant activity of the triiodinated X-ray opaque media iodipamide, iothalamate and diatrizoate on standardized normal human pool plasma was investigated in vitro. We found a dose dependent lengthening of the thrombin time, the reptilase time and the partial thromboplastin time together with a dose dependent drop of the calcium thromboplastin and factor V activity. Iodipamide proved to exert the most pronounced anticoagulant activity of the 3 contrast media tested. The results are interpreted as latent disseminated intravascular coagulation with hyperfibrinolysis following the direct interaction of contrast media with the coagulation enzymes.
D001777:Blood Coagulation / Q000187:drug effects*; D003287:Contrast Media / Q000494:pharmacology*; D003973:Diatrizoate / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D066298:In Vitro Techniques; D007458:Iodipamide / Q000494:pharmacology; D007483:Iothalamic Acid / Q000494:pharmacology
D003287:Contrast Media; D003973:Diatrizoate; D007483:Iothalamic Acid; D007458:Iodipamide
Gerinnungshemmende Wirkungen trijodierter Röntgenkontrastmittel