title: [Rate of development of immunologic memory and features of the secondary immune response in mice of high and low-reacting strains].
abstract: Immunological memory to sheep red blood cells developed in mice of strain CBA, DBA/2, and hybrids (CBAXXC57BL/6) F1 24 hours after the administration of a low dose of the antigen, and in C57BL/6 mice -- in 48 hours. The level of the secondary immune response in CBA, C57BL/6, and hybrid F1 mice was much greater than in the DBA/2 mice. The maximal production of the antibody-forming cells in the spleen of CBA mice occurred after twofold administration of low antigen doses. In contrast to this, repeated administration of a high antigen dose is required to obtain a marked immune response in adoptive transfer of spleen cells of the C57BL/6 strain.
mesh_terms: D000818:Animals; D000921:Antibody-Producing Cells; D000941:Antigens / Q000008:administration & dosage; D004912:Erythrocytes / Q000276:immunology; D006824:Hybridization, Genetic; D007116:Immunization, Passive; D007156:Immunologic Memory; D051379:Mice; D008810:Mice, Inbred C57BL / Q000276:immunology; D008808:Mice, Inbred CBA / Q000276:immunology; D008811:Mice, Inbred DBA / Q000276:immunology; D008815:Mice, Inbred Strains / Q000276:immunology*; D012756:Sheep / Q000276:immunology; D013045:Species Specificity
chemical_list: D000941:Antigens
vernacular_title: Skorost' razvitiia immunologischeskoĭ pamiati i osobennosti vtorichnoĭ immunnoĭ reaktsii u mysheĭ vysoko- i nizkoreagiruiushchikh liniĭ.