title: Inflammatory potential of foreign particulates in parenteral drugs.
abstract: Particulate and bacterial contamination of IV fluids and drugs have been implicated in venous thrombosis, infusion phlebitis, suppurative thrombophlebitis, pyrogenic reactions, and systemic sepsis. In a study of the inflammatory potential of the filterable residue of sodium cephalothin, we have found a tissue-specific reaction with venous endothelium but not with cutaneous or subcutaneous tissues. In a controlled animal model, removal of particulates from an infusion by use of a 0.45 micron in-line membrane filter reduces the incidence and severity of infusion phlebitis.
mesh_terms: D000818:Animals; D002512:Cephalothin; D004285:Dogs; D004340:Drug Contamination; D007249:Inflammation / Q000139:chemically induced*; D007263:Infusions, Parenteral; D007428:Intradermal Tests; D010689:Phlebitis / Q000139:chemically induced; D011817:Rabbits; D012882:Skin Tests; D013924:Thrombophlebitis / Q000139:chemically induced; D014680:Veins / Q000473:pathology
chemical_list: D002512:Cephalothin