[Effect of antibulins on the distribution of fibrillar elements in mouse embryonal fibroblasts].
Effects of colcemid, colchicine and vinblastine on distribution of fibrillar elements (microtubules, microfilaments and 100 A filaments) in mouse embryo fibroblasts were studied by the transmission electron microscopy and by additional treatment of cells with cytochalasin B. All the fibrillar components under routine conditions were seen to form a system of elements with a radial distribution. After antitubulin treatment, the radial system was seen tranformed into a circular one, which consisted mainly of microfilament bundles apparently connecting cell peripheral attachment sites with each other.
D002478:Cells, Cultured; D003593:Cytoplasm / Q000187:drug effects*; D003599:Cytoskeleton / Q000187:drug effects*; D003703:Demecolcine / Q000494:pharmacology*; D008870:Microtubules / Q000187:drug effects*; D014747:Vinblastine / Q000494:pharmacology*
D014747:Vinblastine; D003703:Demecolcine
Vliianie antitubulinov na raspredelenie fibrilliarnykh élementov v myshinykh émbrional'nykh fibroblastakh.