[Structure-activity relationships of bronchospasmolytic beta-phenylethyl-aminoalkyl-xanthines (author's transl)].
Structure-activity relationships of 90 bronchospasmolytic compenylethyl-aminoalkyl-xanthines are reported. Particularly the influence of substituents in the phenyl moiety as well as of the carbon bridge between the xanthine residue and the beta-phenylethylamine moiety is described. 2. A method is shown for the selection of one optimally bronchospasmolytic substance from many potential compounds synthetised via multiple screening steps to profound biological studies.
D000818:Animals; D001980:Bronchi / Q000187:drug effects; D001993:Bronchodilator Agents; D055598:Chemical Phenomena; D002621:Chemistry; D004285:Dogs; D005260:Female; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D010627:Phenethylamines / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014970:Xanthines / Q000494:pharmacology*
D001993:Bronchodilator Agents; D010627:Phenethylamines; D014970:Xanthines; D007545:Isoproterenol
Struktur-Wirkungs-Beziehungen von bronchospasmolytisch wirksamen beta-Phenyläthyl-aminoalkyl-xanthinen