title: Single and low-level oocyst infections of drug-resistant field strains of Eimeria tenella in medicated birds.
abstract: Five out of ten birds infected with a single oocyst of strain Gt2 of Eimeria tenella and medicated with the recommended level of robenidine were found positive in the first experiment and four in the second in comparison with seven and six respectively in nonmedicated birds. Six birds out of ten were found positive in the two groups of similarly medicated birds infected with two or four oocysts each. Although single oocyst infections of strain Lilly 155 were unsuccessful, six out of ten birds were found positive in birds infected with ten oocysts each.All single and low-level oocyst infections were accomplished with oocysts previously treated with beta-glucuronidase and broken into sporocysts prior to infections. The overall results suggested that when a coccidium became resistant to an anticoccidial drug, only one or a few occysts were needed to start an infection if the drug was continued. The results also showed that, perhaps, successful single or low-level oocyst infections can also be used as a criterion for demonstrating drug resistance in coccidia.
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D002645:Chickens; D003048:Coccidiosis / Q000469:parasitology / Q000662:veterinary*; D004351:Drug Resistance; D004539:Eimeria / Q000187:drug effects*; D005260:Female; D005966:Glucuronidase / Q000494:pharmacology; D008297:Male; D011201:Poultry Diseases / Q000188:drug therapy / Q000469:parasitology*
chemical_list: D005966:Glucuronidase