title: [Experimental method for the quantitative assesment of the pain reaction occuring to the injection  of drug preparations].
abstract: The procedure for estimation of painfulness of injection solutions is based on registration of changes in the mobility of albino mice after administration of the solution under the aponeurosis of the anterior pad. The method was tested in the experiments with formaldehyde solutions of various concentrations and a number of drugs used in medical practice. The method provided definition of a clear dependence between the concentration of the irritating substance and the stregth of the animal response. Correlation between the drug painfulness in clinical use and supression level of the animal motor reaction was found.
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005528:Foot; D005557:Formaldehyde / Q000008:administration & dosage; D007267:Injections; D008722:Methods; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009619:Nociceptors / Q000187:drug effects; D010146:Pain / Q000139:chemically induced*; D012965:Sodium Chloride / Q000008:administration & dosage
chemical_list: D005557:Formaldehyde; D012965:Sodium Chloride
vernacular_title: Eksperimental'nyĭ metod kolichestvennoĭ otsenki bolevoĭ reaktsii, voznikaiushcheĭ pri in "ektsii lekarstvennykh preparatov.