title: Blood flow to the genital tract of oestrous and dioestrous guinea-pigs.
abstract: Ovarian, uterine and vaginal blood flow were determined in 22 virgin guinea-pigs by the tracer microsphere technique. Measurements were made during oestrus, when cornified cells appeared in the vaginal smear (Day 1), or during the luteal phase of the cycle (Day 11). The total rate of blood flow to the genital tract was 0-58 ml.min-1 on Day 11 and 2-92 ml.min-1 on Day 1. This difference was largely due to an 8-fold increase in uterine blood flow from 0-26 to 2-01 ml.min-1. Although uterine weight increased over the same period, there was a significant increase in uterine tissue perfusion from 0-32 to 1-18 ml.min-1.g-1. The vagina exhibited a similar pattern, including a significant increase in tissue perfusion. Ovarian blood flow decreased from a value of 0-19 ml.min-1 during the luteal phase to 0-10 ml.min-1 at oestrus. Perfusion of the ovarian tissue was considerably greater on Day 11 than on Day 1 (2-86 versus 1-39 ml.min-1.g-1).
mesh_terms: D000818:Animals; D004031:Diestrus; D004971:Estrus; D005260:Female; D005836:Genitalia, Female / Q000098:blood supply*; D006168:Guinea Pigs / Q000502:physiology*; D009929:Organ Size; D010053:Ovary / Q000098:blood supply; D011247:Pregnancy; D012039:Regional Blood Flow; D014599:Uterus / Q000098:blood supply; D014621:Vagina / Q000098:blood supply