Role of gastric emptying on ethanol poisoning in rats.
Intraperitoneal glucose was demonstrated to significantly inhibit the absorption of ethanol ( 2 g/kg) administered orally to rats. The effect was due to slowed emptying of the stomach, verified by analysis of the stomach contents and of blood enthanol levels. The observation agrees with previous findings, according to which the rate of stomach emptying is inversely related to the blood glucose level. However, when glucose was given intravenously 15 minutes after oral administration of a lethal dose of ethanol (12.5 g/kg) no significant inhibition of ethanol absorption could be observed. Intravenous propantheline, pyrithioxine and methylene blue were also unable to prolong the survival time or to influence the lethal blood ethanol concentration (about 170 mmol/l) of the enthanol-poisoned rats.
D000284:Administration, Oral; D000435:Alcoholic Intoxication / Q000097:blood; D000818:Animals; D000431:Ethanol / Q000008:administration & dosage / Q000097:blood*; D005746:Gastric Emptying / Q000187:drug effects; D005947:Glucose / Q000008:administration & dosage / Q000494:pharmacology; D006801:Humans; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007928:Lethal Dose 50; D008297:Male; D008751:Methylene Blue / Q000494:pharmacology; D011413:Propantheline / Q000494:pharmacology; D011746:Pyrithioxin / Q000494:pharmacology; D051381:Rats
D011413:Propantheline; D000431:Ethanol; D011746:Pyrithioxin; D005947:Glucose; D008751:Methylene Blue