title: A possible interrelationship between gonadotrophin stimulation and prostaglandin F2alpha inhibition of steroidogenesis by granulosa-luteal cells in vitro.
abstract: The newly formed corpus luteum of many species is refractory to the lytic action of prostaglandin F2alpha (PGF2alpha). This phenomenon was studied utilizing porcine, bovine and human granulosa-luteal cells in tissue culture. The steroidogenic potential of the granulosa-luteal cells was critical in determining whether PGF2alpha could inhibit progesterone production. Since the steroidogenic potential of the granulosa-luteal cell is related to the amount of LH bound to the cell, the bound LH may protect the granulosa-luteal cells from the lytic action of PGF2alpha. Finally, a 'see-saw' type of interaction between LH and PGF2alpha is postulated to account for the resistance of the newly formed corpus luteum to PGF2alpha.
mesh_terms: D000818:Animals; D002417:Cattle; D003338:Corpus Luteum / Q000187:drug effects*; D046508:Culture Techniques; D005260:Female; D005640:Follicle Stimulating Hormone / Q000494:pharmacology; D006107:Granulosa Cells / Q000187:drug effects*; D006801:Humans; D008184:Luteal Cells / Q000187:drug effects*; D007986:Luteinizing Hormone / Q000494:pharmacology; D006080:Ovarian Follicle / Q000187:drug effects*; D011374:Progesterone / Q000096:biosynthesis; D011460:Prostaglandins F / Q000494:pharmacology*; D013552:Swine; D013997:Time Factors
chemical_list: D011460:Prostaglandins F; D011374:Progesterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone