The immune response of horses to tetanus toxoid.
An intramuscular injection of 8-16 Lf tetanus toxoid in water-in-oil emulsion protected adult horses against tetanus for at least 128 weeks. A booster dose of 8 Lf toxoid in aqueous solution protected them for a further period of at least 3 1/2 years. Colostral immunity protected foals for at least 10 weeks. An intramuscular injection of 8 Lf toxoid in water-in-oil emulsion given to foals from immune dams when they were 10-18 weeks old did not elicit any antibody response. They did respond, however, to a booster injection of 8 Lf toxoid in aqueous solution given 12 weeks after the first dose. New-born foals were shown to be inherently unable to respond to an injection of tetanus toxoid.
D000276:Adjuvants, Immunologic; D000818:Animals; D003126:Colostrum / Q000276:immunology; D006734:Horse Diseases / Q000517:prevention & control*; D006736:Horses / Q000276:immunology*; D007110:Immunity, Active; D007112:Immunity, Maternally-Acquired; D007114:Immunization; D007115:Immunization Schedule; D013742:Tetanus / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D013745:Tetanus Toxoid / Q000276:immunology*; D013997:Time Factors
D000276:Adjuvants, Immunologic; D013745:Tetanus Toxoid