[Current status of granulocyte separation and transfusion].
Granulocyte substitution therapy is of definitive clinical value when correctly indicated and consequently performed. Comparing the different techniques for leucocyte separation, the combination of continuous flow centrifugation (CFC) and filtration (FL) permits the highest yield of granulocytes. As yet, all available methods imply a rather high degree of inconvenience and a considerable rate of side effects for the (normal) donor which cannot easily be justified from a medical point of view. On the other hand, CFC and especially FL have a great potential for further improvement. Hence, higher yields and less donor affection are expectable. Granulocyte procurement is a great challenge to existing transfusion centres requiring their future engagement and expansion in this new and important field.
D001803:Blood Transfusion / Q000379:methods*; D002469:Cell Separation / Q000379:methods; D006098:Granulocytes; D006801:Humans
Aktueller Stand der Granulozytenseparation und -transfusion.