[Changes in the endomembrane system and mitochondria of cultured chick fibroblasts upon application of colchicine and following its withdrawal].
After the administration of colchicine (5 mcg/ml) into nutritive medium of primary tissue culture there is a remarkable decrease in the volume and number of fibroblast-membrane organoids during the first 3 hours. The removing of colchicine-damaged fibroblasts into the medium without colchicine leads to the renewal of the most of intracellular membranes during the following 24 hours. Probable reasons and mechanisms of colchicine-induced alterations are discussed.
D000818:Animals; D002478:Cells, Cultured; D002642:Chick Embryo; D003078:Colchicine / Q000494:pharmacology*; D005347:Fibroblasts / Q000187:drug effects / Q000648:ultrastructure; D007425:Intracellular Membranes / Q000187:drug effects*; D008928:Mitochondria / Q000187:drug effects*
D003078:Colchicine
Izmenenie éndomembrannoĭ sistemy i mitokhondriĭ v kul'tiviruemykh kurinykh fibroblastakh pri deĭstvii kolkhitsina i posle ego udaleniia. Morfometricheskiĭ analiz.