Local anesthetics and pulmonary venous admixture in pregnant and nonpregnant sheep.
Pulmonary venous admixture (Qs/Qt) was determined in nine nonpregnant sheep and in seven pregnant sheep during their last trimesters of gestation. Pulmonary venous admixture was greater in the pregnant animals (5.7 +/- 1.6% of the cardiac output; mean +/- SD) than in the nonpregnant ones (4.2 +/- 1.3%; p less than 0.05). On consecutive days, four local anesthetics were infused in random order via a femoral venous catheter into each sheep for 30 minutes. Total doses of 1.8 mg/kg of bupivacaine, 2.7 mg/kg of etidocaine, 6 mg/kg of lidocaine, and 15 mg/kg or chloroprocaine were administered. None of the anesthetics induced a significant change in pulmonary venous admixture.
D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D001012:Aorta, Abdominal; D002045:Bupivacaine / Q000097:blood / Q000494:pharmacology; D005041:Etidocaine / Q000097:blood / Q000494:pharmacology; D005260:Female; D008012:Lidocaine / Q000097:blood / Q000494:pharmacology; D008168:Lung / Q000098:blood supply / Q000187:drug effects; D010100:Oxygen / Q000097:blood*; D011247:Pregnancy; D011270:Pregnancy, Animal; D011343:Procaine / Q000097:blood / Q000494:pharmacology; D011651:Pulmonary Artery; D012756:Sheep; D014682:Vena Cava, Inferior; D014692:Ventilation-Perfusion Ratio
D000779:Anesthetics, Local; D011343:Procaine; D008012:Lidocaine; D005041:Etidocaine; D010100:Oxygen; D002045:Bupivacaine