Role of endogenous interferon in the anti-tumor effect of poly I-C and statolon as demonstrated by the use of anti-mouse interferon serum.
We have determined the effect of sheep anti-mouse interferon globulin on the anti-tumor effects of poly I-C, statolon, tilorone, pyran copolymer and BCG in mice inoculated with Ehrlich ascites or L 1210 lymphoma cells. Whereas the anti-tumor effects of poly I-C and statolon were nulified when mice were injected with immunoglobulins, the anti-tumor effects of pyran copolymer and BCG were not modified by this treatment. We conclude that interferon mediates the anti-tumor activity of poly I-C and statolon in these experimental systems. It is suggested that anti-interferon serum provides a direct method of determining whether other biologic effects attributed to viruses, poly I-C, statolon, tilorone, pyran copolymer (and possibly other interferon inducers) are mediated or not by interferon.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001500:BCG Vaccine / Q000627:therapeutic use; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D002460:Cell Line; D004357:Drug Synergism; D007372:Interferons / Q000276:immunology / Q000502:physiology*; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D011070:Poly I-C / Q000627:therapeutic use*; D011134:Polysaccharides / Q000627:therapeutic use*; D011713:Pyran Copolymer / Q000627:therapeutic use; D013994:Tilorone / Q000627:therapeutic use
D000970:Antineoplastic Agents; D001500:BCG Vaccine; D011134:Polysaccharides; D011713:Pyran Copolymer; D007372:Interferons; D013994:Tilorone; D011070:Poly I-C