The effect of baclofen and aminooxyacetic acid on the action of drugs stimulating the dopaminergic system.
Baclofen and aminooxyacetic acid (AOAA) depressed the explorative and locomotor activity in rats. Baclofen, but not AOAA, decreased the locomotor stimulation, produced by apomorphine. Both compounds did not affect hyperactivity, induced by D, L-amphetamine, amantadine and methylphenidate. Neither baclofen nor AOAA influenced stereotypy induced by the above four substances.
D000085:Acetates / Q000494:pharmacology*; D000547:Amantadine / Q000494:pharmacology; D000625:Aminooxyacetic Acid / Q000494:pharmacology*; D000662:Amphetamines / Q000494:pharmacology; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001418:Baclofen / Q000494:pharmacology*; D004347:Drug Interactions; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects*; D013239:Stereotyped Behavior / Q000187:drug effects
D000085:Acetates; D000662:Amphetamines; D011954:Receptors, Dopamine; D000625:Aminooxyacetic Acid; D008774:Methylphenidate; D000547:Amantadine; D001418:Baclofen; D001058:Apomorphine