title: Derivatives of 3.3-spiro-bi-5-methyl-5'-alkylaminomethyl-tetrahydrofuranone-2 as potential neurotropic agents. II.
abstract: Dilactone of gamma-bromo-beta-hydroxypropyl-beta-hydroxypropyl malonic acid 2 was prepared. By condensation with secondary or primary amines the tertiary amines 3--7. resp. the secondary amines 8--10 were obtained. The reaction of 2 with tertiary amines gave the corresponding ammonium salts 11--12. All the compounds are subjected to pharmacological examination.
mesh_terms: D000818:Animals; D002375:Catalepsy / Q000139:chemically induced / Q000503:physiopathology; D005663:Furans / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D009043:Motor Activity / Q000187:drug effects; D011619:Psychotropic Drugs / Q000138:chemical synthesis*; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D013239:Stereotyped Behavior / Q000187:drug effects
chemical_list: D005663:Furans; D011619:Psychotropic Drugs; D013141:Spiro Compounds