Absorption of amino acids from the small bowel and their activity in releasing of cholecystokinin.
The ability of essential and nonessential amino acids to stimulate the release of CCK was investigated in dogs using a bioassay procedure based on the perfusion of intestinal Thiry-Vella loops and determing the increase of pancreatic protein response as well as the potentiation of pancreatin bicarbonate secretion by a background doses of secretin (0.2 units/kg/h). All essential amino acids, except threonine, and all nonessential amino acids except cysteine were effective in CCK release when perfused in equimolar concentration (50-mM) through the intestinal loop. The peak pancreatic protein in response to tryptophan was about 89% of the maximal response to exogenous CCK in a dose of 25 units/kg/h. These data have also indicated that tryptophan and phenyloalanine are able to release small amounts of secretin.
D000596:Amino Acids / Q000378:metabolism* / Q000502:physiology*; D000601:Amino Acids, Essential / Q000378:metabolism / Q000502:physiology; D000818:Animals; D001639:Bicarbonates / Q000378:metabolism; D002766:Cholecystokinin / Q000378:metabolism* / Q000494:pharmacology; D004285:Dogs; D007413:Intestinal Mucosa / Q000378:metabolism*; D007421:Intestine, Small / Q000378:metabolism*; D010179:Pancreas / Q000378:metabolism; D011506:Proteins / Q000378:metabolism
D000596:Amino Acids; D000601:Amino Acids, Essential; D001639:Bicarbonates; D011506:Proteins; D002766:Cholecystokinin