Metabolic effects of some antibilharzial drugs. Studies on the inhibitory action of "bilharcid" on succinate oxidation in normal rat liver.
THE INHIBITION of succinate oxidation by Piperazine diantimonyl tartarate (Bilharcid) could be in part attributed to accumulation of oxaloacetate. This is discussed with reference to the effect of ATP, glutamate and cysteine on the reversal of the inhibitory action, of the drug on succinate oxidation.
D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D000965:Antimony / Q000378:metabolism / Q000494:pharmacology*; D003545:Cysteine / Q000494:pharmacology; D005971:Glutamates / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D010071:Oxaloacetates / Q000378:metabolism; D051381:Rats; D012556:Schistosomicides / Q000378:metabolism / Q000494:pharmacology*; D013385:Succinate Dehydrogenase / Q000378:metabolism*
D005971:Glutamates; D010071:Oxaloacetates; D012556:Schistosomicides; D000255:Adenosine Triphosphate; D000965:Antimony; D013385:Succinate Dehydrogenase; D003545:Cysteine