[The influence of treatments with a quinine-lithium-salicylate combination or acetylsalicylic acid on hematopoiesis in mice (author's transl)].
The effects of an 8-week treatment with the quinine-lithium-salicylate combination Togal and sole acetylsalicylic acid (ASA) on the hemopoietic bone marrow cells of mice were studied. In general, both substances caused only minor changes. A slight leukopenia caused by higher doses as well as a transitory erythropenia observed a little bit more distinctly in ASA treated animals than in Togal treated animals need more detailed discussion, especially so because after a short two-week Togal treatment some animals showed an increase of hemopoietic cell colonies which a sole ASA dose did not cause. On the other hand, these results indicate a lower toxicity of Togal in comparison with acetylsalicylic acid as has been already shown in several other publications. It was proven that after a several weeks' treatment with therapeutic doses no pernicious influence on blood producing organs or pathological processes of the blood picture occurred. Only doses that border on the toxic region lead to insignificant bone marrow changes. As these over-doses are ten times the highest therapeutical dose the use of Togal does any damage to the blood forming tissue or pathological changes in the blood count are not likely. This has also been proved by other authors by means of long-term tests on humans.
D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D004338:Drug Combinations; D004906:Erythrocyte Count; D006168:Guinea Pigs; D006400:Hematocrit; D006410:Hematopoiesis / Q000187:drug effects*; D007958:Leukocyte Count; D008094:Lithium / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D011803:Quinine / Q000494:pharmacology*; D012459:Salicylates / Q000494:pharmacology*; D013997:Time Factors
D004338:Drug Combinations; D012459:Salicylates; D008094:Lithium; D011803:Quinine; D001241:Aspirin
Die Beeinflussung der Hämatopoese bei Mäusen nach Behandlung mit einer Chinin-Lithium-Salicylat-Kombination und Acetylsalicylsäure.