Effect of 1,5-dicaffeylquinic acid (cynarine) on cholesterol levels in serum and liver of acute ethanol-treated rats.
The effect of 1,5-dicaffeylquinic acid (Cynarine) on total cholesterol levels in serum and liver of acute ethanol-treated rats was studied. Male Wister rats were administered ethyl alcohol, 6 g/kg per day by gavage over three days. In rats treated with ethanol alone, the serum and hepatic cholesterol showed a significant rise of 44 and 75%, respectively. In rats receiving ethanol and Cynarine simultaneously, a distinct reduction of the serum and hepatic cholesterol levels was observed.
D000818:Animals; D002784:Cholesterol / Q000097:blood*; D002934:Cinnamates / Q000494:pharmacology*; D000431:Ethanol / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051381:Rats
D002934:Cinnamates; D000431:Ethanol; D002784:Cholesterol