title: [Anaemia and microcytosis during thyrotoxicosis. Physiopathological discussion. 36 cases (author's transl)].
abstract: Study of 36 cases of thyrotoxicosis demonstrated the prevalence of anaemia (17 cases) and of microcytosis (26 cases). In patients with a microcytosis, serum iron was measured in 9, being found to be low in 5 of them, whilst amongst twelve 10 had anti-thyroid antibodies and anti-gastric antibodies. Atrophic gastritis was seen in the 5 patients who underwent endoscopy. Four biopsies revealed 3 cases of atrophic gastritis and one of simple gastritis. The types of anaemia seen and their mechanisms are discussed: microcytic anaemia related to disturbed iron metabolism or to its impaired intestinal absorption; normocytic anaemia; macrocytic anaemia possibly preceding pernicious anaemia. It would seem to be possible to distinguish two pathogenic categories: thyrotoxicosis reversible changes in iron metabolism, and atrophic gastritis associated with hyperthyroidis in an "auto-immune context" and which has led to the concept of "thyro-gastric" disease.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000740:Anemia / Q000209:etiology*; D000747:Anemia, Hypochromic / Q000209:etiology; D000748:Anemia, Macrocytic / Q000209:etiology; D000752:Anemia, Pernicious / Q000209:etiology; D001323:Autoantibodies / Q000032:analysis; D004913:Erythrocytes, Abnormal; D005260:Female; D005756:Gastritis / Q000150:complications / Q000276:immunology; D006111:Graves Disease / Q000097:blood / Q000150:complications* / Q000276:immunology; D006801:Humans; D007501:Iron / Q000097:blood; D008297:Male; D008875:Middle Aged
chemical_list: D001323:Autoantibodies; D007501:Iron
vernacular_title: Anémie et microcytose au cours de la maladie de Basedow. Discussion physio-pathologique. 36 observations.