Metabolic effects of clofibrate on experimental animals.
The effect of ethyl-alpha-(p-chlorophenoxy)-isobutyrate (clofibrate, Miscleron) on certain parameters of lipid and carbohydrate metabolism was studied in male and female white rats. The vitamin A content and the mixed function oxydase activity in the liver was also examined. 1. In short-term experiments over 10 to 30 days clofibrate significantly influenced the examined parameters. In a long-term experiment (9 months), however, these changes were no more observable. 2. Clofibrate exerted a protective effect against lipid mobilization following physical exercise (swimming). 3. No significant differences between male and female rats after clofibrate treatment could be observed.
D000818:Animals; D002994:Clofibrate / Q000494:pharmacology*; D005260:Female; D007668:Kidney / Q000378:metabolism; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008099:Liver / Q000378:metabolism; D008297:Male; D008660:Metabolism / Q000187:drug effects*; D005082:Physical Exertion; D051381:Rats; D012737:Sex Factors; D013550:Swimming; D013997:Time Factors
D008055:Lipids; D002994:Clofibrate