title: Synthesis of a 125I-labelled derivative of the antibiotic griseofulvin.
abstract: A derivative of griseofulvin has been synthesised, in which the 2'-O-methyl group is replaced by a 2'-(2-iodoethoxy), 125I-labelled group. This derivative is at least as potent as griseofulvin itself, when assayed for inhibition of growth on the Myxomycete Physarum polycephalum.
mesh_terms: D006118:Griseofulvin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D007457:Iodine Radioisotopes; D010804:Physarum / Q000187:drug effects
chemical_list: D007457:Iodine Radioisotopes; D006118:Griseofulvin