Role of complement in thrombogenesis. I. Complement-dependent coagulation in a model system.
Chondroitin sulphate was used to isolate from plasma a system that clotted with Russell's viper venom, brain extract and activated contact factors. Clotting appeared to depend on concomitant change in C4, C3 and C1s in the system. Brain extract additionally reacted with C9. Reconstitution of specifically defective plasmas suggested a specific role for each of these complement components in clotting.
D000937:Antigen-Antibody Reactions; D001777:Blood Coagulation; D001792:Blood Platelets / Q000187:drug effects; D002809:Chondroitin Sulfates; D003029:Coagulants / Q000494:pharmacology; D003174:Complement C1 Inactivator Proteins / Q000378:metabolism; D003176:Complement C3 / Q000378:metabolism; D003181:Complement C4 / Q000378:metabolism; D003182:Complement C5 / Q000378:metabolism; D003186:Complement C9 / Q000378:metabolism; D003165:Complement System Proteins / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques
D003029:Coagulants; D003174:Complement C1 Inactivator Proteins; D003176:Complement C3; D003181:Complement C4; D003182:Complement C5; D003186:Complement C9; D002809:Chondroitin Sulfates; D003165:Complement System Proteins