title: [Influence of single and repeated administration of desipramine (DMI) on the secretion of growth hormone (GH) (author's transl)].
abstract: DMI leads to stimulation of GH in healthy male subjects 60--120 min after i.m. injection and 150--210 min after oral application. During a 20-day administration of 2 x 75 mg DMI per day a repeated stimulation of GH was provable on days 0, 10 and 20 in two male patients, whereas no stimulation of GH occurred in two female patients who underwent the same treatment. The GH basic secretion did not increase in any of the four after patients 10 and 20 days, respectively. Neither prolactin (PRL) nor thyreotrophin (TSH) serum concentrations are influenced by DMI. The increase in PRL and TSH, which is induced by the thyrotrophin releasing hormone (TRH), is provable after acute as well as after chronic administration of DMI.
mesh_terms: D000328:Adult; D003891:Desipramine / Q000008:administration & dosage / Q000494:pharmacology*; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D008297:Male; D011388:Prolactin / Q000097:blood; D013268:Stimulation, Chemical; D013972:Thyrotropin / Q000097:blood; D013997:Time Factors
chemical_list: D011388:Prolactin; D013972:Thyrotropin; D013006:Growth Hormone; D003891:Desipramine
vernacular_title: Beeinflussung der Hypophysen-Vorderlappen-Hormon-Sekretion nach akuter und chronischer Gabe von Desipramin.