Restoration of the bone marrow pluripotent stem cells in AKR mice after arabinosylcytosine treatment.
The hypothesis of repression of multipotent stem cells (CFU) by leukemic cells to explain their depletion, previously demonstrated in AKR leukemic mice, was tested. Using arabinosylcytosine to destroy leukemic cells, it was shown that the bone marrow CFU pool was acutely depressed between 2 h and 12 h after treatment. However, 5 to 7 days later, this pool was restored, surpassing the value of the bone marrow pool in normal mice. This seems to indicate that the CFU pool in leukemic mice is potentially capable of proliferating but is repressed by leukemic cells.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D003561:Cytarabine / Q000494:pharmacology*; D005260:Female; D007938:Leukemia / Q000473:pathology*; D051379:Mice; D008806:Mice, Inbred AKR; D009929:Organ Size / Q000187:drug effects; D013154:Spleen / Q000187:drug effects; D013268:Stimulation, Chemical; D013950:Thymus Gland / Q000187:drug effects
D003561:Cytarabine