Effects of creatinol-O-phosphate (COP) on haemodynamics and cardiac metabolism in conscious and anaesthetized dogs.
The effects of creatinol-O-phosphate (COP, Aplodan) have been studied on haemodynamics and cardiac metabolism of virtually normal heart (conscious dogs with electromagnetic probes chronically implanted) and progressively failing heart (open chest anaesthetized dogs). The results obtained show that COP in both series of experiments increased cardiac work and improved some myocardial metabolic parameters (delta redox potential across the heart, lactate/pyruvate ratio, excess lactate) probably by enhancing the myocardial O2 supply-consumption ratio, and consequently increasing the amount of O2 available for energetic reactions in the cardiac muscle and possibly in other tissues as well.
D000818:Animals; D001775:Blood Circulation / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D003401:Creatine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004285:Dogs; D006321:Heart / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D009206:Myocardium / Q000378:metabolism*; D010084:Oxidation-Reduction; D010101:Oxygen Consumption / Q000187:drug effects; D010313:Partial Pressure; D014690:Venous Pressure / Q000187:drug effects
D003401:Creatine