title: Hypoglycemic activity of amine derivatives. Preliminary observations.
abstract: Dicyclohexylamine and related amino compounds as well as some simple secondary amines with branched aliphatic substituents were found to decrease blood glucose levels of fasted, glucose-loaded, or streptozotocin-diabetic rats, and of fasted mice. Structure-activity relationships are discussed.
mesh_terms: D000588:Amines / Q000494:pharmacology*; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000097:blood; D005260:Female; D005951:Glucose Tolerance Test; D007004:Hypoglycemic Agents; D008297:Male; D051379:Mice; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D000588:Amines; D007004:Hypoglycemic Agents