Metabolic activation of diethylstilbestrol and aminostilbene-derivatives.
Diethylstilbestrol and trans-4-dimethylaminostilbene are metabolically activated and several of their metabolites are able to react with cellular macromolecules. Some of the problems are discussed which are encountered in linking a particular metabolite with the mutagenic and carcinogenic properties of these compounds.
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D002273:Carcinogens; D055598:Chemical Phenomena; D002621:Chemistry; D004054:Diethylstilbestrol / Q000378:metabolism; D004852:Epoxy Compounds / Q000378:metabolism; D005978:Glutathione; D009153:Mutagens; D009603:Nitroso Compounds / Q000378:metabolism; D011485:Protein Binding; D051381:Rats; D013267:Stilbenes / Q000378:metabolism*
D001798:Blood Proteins; D002273:Carcinogens; D004852:Epoxy Compounds; D009153:Mutagens; D009603:Nitroso Compounds; D013267:Stilbenes; D004054:Diethylstilbestrol; D005978:Glutathione