Effects of cordacin on lymphocyte activity in vitro.
The effects of cordacin on lymphocyte activity were studied with two parameters in vitro. The cordacin inhibited T lymphocyte E rosette formation by 93% at the concentration of 1,000 microgram/ml and tritiated-thymidine incorporation into PHA-transformed lymphocytes by 66% at the concentration of 10 microgram/ml. The implication of these results on replicating leukemic as well as normal cells is discussed.
D000970:Antineoplastic Agents / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis; D006801:Humans; D008213:Lymphocyte Activation; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D012397:Rosette Formation
D000970:Antineoplastic Agents; D010936:Plant Extracts; D004247:DNA