title: [Circadian fluctuations of pharmacokinetic parameters after oral administration of hexobarbital (author's transl)].
abstract: To 4 male and 2 female subjects hexobarbital was applied orally at different times of the day: 2, 10, 18 h. Serum concentrations of hexobarbital were determined by HPLC procedure and the resulting pharmacokinetic parameters in a rotating iterative program. Application at 18 h resulted in a shorter invasion time, a higher maximum concentration and a delayed elimination; in addition, the AUC was elevated in relation to application at 2 or 10 h. In the 2 female subjects a different pattern was observed. The results lead to the assumption that application of hexobarbital is more effective in the evening than in the morning.
mesh_terms: D000328:Adult; D002940:Circadian Rhythm; D005260:Female; D006591:Hexobarbital / Q000097:blood / Q000378:metabolism* / Q000652:urine; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D013997:Time Factors
chemical_list: D006591:Hexobarbital
vernacular_title: Zirkadiane Schwankungen pharmakokinetischer Parameter nach oraler Gabe von Hexobarbital.