[Antimalarial 6-aminoquinolines. VII. 2- and 4-Alkoxy derivatives of 6-(4-diethylamino-1-methylbutylamino)-5,8-dimethoxyquinoline (author's transl)].
19 derivatives, 10 a--t, of 6-(4-diethylamino-1-methylbutylamino)-5,8-dimethoxyquinoline (1a) with alkoxy-, hydroxy-, and methylmercapto substituents in 4- and/or 2-position were synthesized with the aim of studying the influence of these substituents on antimalarial activity and toxicity of 1a. The alkoxy derivatives of 1a are highly active against P. vinckei (mouse). The 2- and 4-hydroxy derivatives, 10 l and 10 m, are inactive.
D000634:Aminoquinolines / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D000962:Antimalarials; D055598:Chemical Phenomena; D002621:Chemistry; D007928:Lethal Dose 50; D051379:Mice; D012995:Solubility
D000634:Aminoquinolines; D000962:Antimalarials
Gegen Malaria wirksame 6-Aminochinoline. VII. Mitteilung: 2- und 4-Mono- und Dialkoxyderivate von 6-(4-Diäthylamino-1-methylbutylamino)-5,8-dimethoxychinolin).