Aminopyrine breath test in alcoholic liver disease and in patients on enzyme-inducing drugs.
The 14C-aminopyrine breath test was used to measure liver function in 14 normal subjects, 16 patients with alcoholic cirrhosis, 14 alcoholics without cirrhosis, and 29 patients taking a variety of drugs. The normal value for the breath test was 8.6 +/- 1.5%, whereas it was significantly lower (5.1 +/- 3.8%) in patients with alcoholic cirrhosis. Higher than normal values were found in some alcoholic patients without cirrhosis and in patients receiving enzyme-inducing drugs, such as phenobarbitone. There was a significant correlation between serum gamma-glutamyltransferase and breath test in these groups. Some patients with alcoholic cirrhosis may also be capable of enzyme induction.
D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000437:Alcoholism / Q000201:enzymology / Q000503:physiopathology; D000632:Aminopyrine; D001463:Barbiturates / Q000008:administration & dosage; D001944:Breath Tests; D004790:Enzyme Induction; D006801:Humans; D008103:Liver Cirrhosis / Q000503:physiopathology; D008104:Liver Cirrhosis, Alcoholic / Q000201:enzymology / Q000503:physiopathology*; D008111:Liver Function Tests; D009892:Opium / Q000008:administration & dosage
D000305:Adrenal Cortex Hormones; D001463:Barbiturates; D000632:Aminopyrine; D009892:Opium