Azidocillin levels in tracheobronchial secretions.
Concentrations of azidocillin in serum and tracheobronchial secretions were followed in 20 patients after an oral dose of 0.75 g of the drug. Serum concentrations were followed for 4 h and the concentration in tracheobronchial secretion was determined in samples taken through a fibreoptic bronchoscope 1--2 h after administration. The concentration in secretions varied between hardly measurable levels and 1.1 micrograms/ml. No correlation between levels in serum and tracheobronchial secretion was found. A slight tendency to higher secretion levels was found when the bronchoscopy showed signs of tracheobronchitis.
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D001980:Bronchi / Q000378:metabolism*; D001999:Bronchoscopy; D005260:Female; D005336:Fiber Optic Technology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010400:Penicillin G / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000032:analysis* / Q000097:blood; D010406:Penicillins / Q000032:analysis*
D010406:Penicillins; D010400:Penicillin G