Hemoglobin Thailand [alpha 56 (E 5) Lys leads to Thr]: a new abnormal human hemoglobin.
A healthy Thai male was found to have an abnormal hemoglobin moving faster than Hb A in starch-gel electrophoresis, in addition to the normal hemoglobin constituents. The abnormal hemoglobin constituted 28% of the whole hemoglobin. The subject was asymptomatic and had normal hematologic findings. Structural characterization revealed that the amino acid substitution was alpha 56 Lys leads to Thr. This variant has never been described previously and it is named Hb Thailand.
D000085:Acetates / Q000494:pharmacology; D000596:Amino Acids; D004592:Electrophoresis, Starch Gel; D005914:Globins / Q000302:isolation & purification; D006455:Hemoglobins, Abnormal / Q000302:isolation & purification*; D006801:Humans; D008239:Lysine / Q000378:metabolism*; D008297:Male; D010455:Peptides / Q000302:isolation & purification; D013785:Thailand; D013912:Threonine / Q000378:metabolism*
D000085:Acetates; D000596:Amino Acids; D006455:Hemoglobins, Abnormal; D010455:Peptides; D013912:Threonine; D005914:Globins; D008239:Lysine