Cholinergic mechanisms involved in head-shaking of infant rats.
Central cholinergic mechanisms involved in D-amphetamine induced head-shaking (H-S) were explored in 9-day-old albino rats using anticholinergic, anticholinesterase and cholinomimetic drugs. Scopolamine (5 mg/kg, IP) blocks both spontaneous and D-amphetamine induced H-S. Physostigmine (0.10 mg/kg, IP), but not neostigmine, increases D-amphetamine induced H-S up to 400%. Pilocarpine (1-10 mg/kg, IP) per se induces H-S and strongly potentiates the amphetamine H-S effect. Cholinergic--catecholaminergic interactions in the CNS are discussed in relation to the expression of this motor item.
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D003913:Dextroamphetamine / Q000494:pharmacology; D004347:Drug Interactions; D010275:Parasympathetic Nervous System / Q000502:physiology*; D010862:Pilocarpine / Q000494:pharmacology; D051381:Rats; D012601:Scopolamine / Q000494:pharmacology
D002800:Cholinesterase Inhibitors; D010862:Pilocarpine; D012601:Scopolamine; D003913:Dextroamphetamine