Effect of steroids and diethylstilbestrol on cocaine toxicity, plasma concentrations and urinary excretion.
Comparative experiments were performed on female rats given pregnenolone-16 alpha-carbonitrile (PCN), spironolactone, triamcinolone, estradiol or diethylstilbestrol to study correlations between the toxic effect of cocaine, its blood clearance and its urinary excretion. PCN and estradiol significantly reduced the toxicity of the drug as well as its plasma levels and urinary excretion. Diethylstilbestrol and spironolactone, unlike triamcinolone, also diminished cocaine toxicity and plasma concentrations.
D000818:Animals; D003042:Cocaine / Q000097:blood / Q000633:toxicity* / Q000652:urine; D004054:Diethylstilbestrol / Q000494:pharmacology*; D004347:Drug Interactions; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D011285:Pregnenolone Carbonitrile / Q000494:pharmacology; D051381:Rats; D013148:Spironolactone / Q000494:pharmacology; D013256:Steroids / Q000494:pharmacology*; D013997:Time Factors; D014221:Triamcinolone / Q000494:pharmacology
D013256:Steroids; D011285:Pregnenolone Carbonitrile; D014221:Triamcinolone; D013148:Spironolactone; D004958:Estradiol; D004054:Diethylstilbestrol; D003042:Cocaine