title: Anaemia, iron deficiency and exercise: extended studies in human subjects.
abstract: 1. Ventilation and cardiac frequency were measured during repeated treadmill exercise in three healthy subjects over 36 weeks, before, during and after iron-deficiency anaemia was produced and after iron treatment. The haemoglobin and 2,3-diphosphoglycerate concentrations and the oxygen-binding (P50) were measured. 2. There was an inverse relationship between the haemoglobin concentrations and the 2,3-diphosphoglycerate concentrations and the P50 values. 3. The mean cardiac frequencies during the fourth to tenth minutes of exercise showed a negative correlation with the haemoglobin concentrations in all three subjects, and the mean minute ventilations in two of them.
mesh_terms: D000328:Adult; D000747:Anemia, Hypochromic / Q000503:physiopathology*; D004163:Diphosphoglyceric Acids / Q000097:blood; D006339:Heart Rate; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D005082:Physical Exertion; D012123:Pulmonary Ventilation
chemical_list: D004163:Diphosphoglyceric Acids; D006454:Hemoglobins