The role of bile acids in phalloidin poisoning.
Glycocholate and other bile acids inhibit the response of isolated hepatocytes to phalloidin in a concentration dependent manner. It is suggested that the inhibition is due to a block of phalloidin uptake. This interaction might explain the high specificity of phalloidin for liver tissue.
D000818:Animals; D001647:Bile Acids and Salts / Q000502:physiology*; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects; D009842:Oligopeptides / Q000506:poisoning*; D010590:Phalloidine / Q000037:antagonists & inhibitors / Q000506:poisoning*; D051381:Rats; D013997:Time Factors
D001647:Bile Acids and Salts; D009842:Oligopeptides; D010590:Phalloidine