title: Jaundice phototherapy: micro flow-cell photometry reveals rapid biliary response of Gunn rats to light.
abstract: Hepatic pigment clearance in rats can be followed continuously with photometric detectors designed for high-pressure liquid chromatography. This method showed that light has a fast effect on bilirubin metabolism in homozygous Gunn rats, even at low doses and intensities. This is consistent with geometric isomerization of bilirubin IXalpha as a primary step in phototherapy.
mesh_terms: D000818:Animals; D001646:Bile / Q000378:metabolism; D001663:Bilirubin / Q000097:blood / Q000378:metabolism* / Q000528:radiation effects; D004195:Disease Models, Animal; D006801:Humans; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000628:therapy*; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D010789:Phototherapy; D051381:Rats
chemical_list: D001663:Bilirubin