Study of the repercussions on blood of acute experimental inflammation in rats. I. Systemic effects induced by generalised inflammation with dextran.
Systemic effects resulting from dextran induced general inflammation in rats were studied. The phlogogenic agent was i.p. or i.v. injected. Dextran led to an increase in hematocrit values and erythrocyte counts. A decrease in blood total proteins, fibrinogen and sedimentation rate was observed, too. ADP mediated platelet aggregation was also decreased.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D003911:Dextrans / Q000494:pharmacology*; D004906:Erythrocyte Count; D005070:Evans Blue; D006400:Hematocrit; D007249:Inflammation / Q000097:blood* / Q000139:chemically induced; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats; D013997:Time Factors
D001798:Blood Proteins; D003911:Dextrans; D005070:Evans Blue; D000244:Adenosine Diphosphate