[Hydroxylation of testosterone and induction of steroid hydroxylases by phenobarbital in genetically obese mice (author's transl)].
In spite of the profound alterations in lipid metabolism in the liver of genetically obese mice (strain C57 BL/6J) the activity of the hepatic hydroxylases with testosterone as substrate does not differ from that of their litter mates of normal weight. However, when the increased liver weight of the obese animals is taken into account their total capacity for steroid hydroxylation exceeds that of their litter mates by a factor of more than 2. Moreover, the inducibility of the membrane-bound enzyme system is not affected: application of phenobarbital (20 or 40 mg/kg body weight twice daily for 4 days) leads to a 2--3fold increase of the activity.
D000818:Animals; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D006900:Hydroxylation; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000235:genetics / Q000378:metabolism*; D009929:Organ Size; D010634:Phenobarbital / Q000494:pharmacology*; D013250:Steroid Hydroxylases / Q000096:biosynthesis*; D013739:Testosterone / Q000378:metabolism*
D013739:Testosterone; D013250:Steroid Hydroxylases; D010634:Phenobarbital
Hydroxylierung von Testosteron und Induktion der Steroid-Hydroxylasen durch Phenobarbital bei genetisch adipösen Mäusen.