[The influence of a combination of clonidine and acetylandromedol on blood pressure and central sympathetic tone of the cat (author's transl)].
The effects of acetylandromedol alone and in combination with 2-(2,6-dichlorophenolamino)-2-imidazoline hydrochloride (clonidine) on the arterial blood pressure and the preganglionic discharges of the cervical sympathetic and phrenic nerves were studied in 36 anaesthetized cats. At a dosage of 10--40 micrograms/kg i.v. acetylandromedol produced a fall of blood pressure and an increase of the central nervous sympathetic activity. Both effects lasted longer than 1 h. The combination of 40 micrograms acetylandromedol/kg with 15 micrograms clonidine/kg i.v. caused a decrease of the sympathetic activity. A depression of the respiratory centres was not observed. 10 micrograms acetylandromedol/kg in combination with 15 micrograms clonidine/kg produced a significantly more pronounced hypotensive action than the single application of 20 micrograms acetylandromedol/kg or 30--120 micrograms clonidine/kg.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001339:Autonomic Fibers, Preganglionic / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects*; D002415:Cats; D003000:Clonidine / Q000008:administration & dosage / Q000494:pharmacology*; D004224:Diterpenes / Q000008:administration & dosage / Q000494:pharmacology*; D004347:Drug Interactions; D007275:Injections, Intravenous; D010791:Phrenic Nerve / Q000187:drug effects; D013564:Sympathetic Nervous System / Q000187:drug effects*; D014118:Toxins, Biological / Q000008:administration & dosage / Q000494:pharmacology*
D004224:Diterpenes; D014118:Toxins, Biological; D003000:Clonidine
Der Einfluss kombinierter Gaben von Clonidin und Acetylandromedol auf den Blutdruck und den zentralen Sympathikustonus der Katze.