Influence of cicloxilic acid on the intracellular transport of 3H-palmitic acid during acute ethanol fatty liver.
cis-2-Hydroxy-2-phenyl-cyclohexanecarboxilic acid (cicloxilic acid) modifies the rat's hepatocyte intracellular movements of 3H-palmitic acid in the course of fatty liver by acute ethanol intoxication. It counteracts the impairment of radioactive lipid uptake due to ethanol treatment and promotes the early and complete release of the radioisotope inhibited by ethanol. The relevance of these results to the role of changes in the intracellular transport systems in the pathogenesis of ethanol steatosis is discussed. This and previous studies show that cicloxilic acid acts by stimulating the intracellular lipoprotein transport probably preventing by this mechanism the ethanol induced liver injury.
D000818:Animals; D003509:Cyclohexanecarboxylic Acids / Q000494:pharmacology*; D003600:Cytosol / Q000187:drug effects / Q000378:metabolism; D005235:Fatty Liver, Alcoholic / Q000378:metabolism*; D005260:Female; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D010169:Palmitic Acids / Q000378:metabolism*; D051381:Rats; D013997:Time Factors
D003509:Cyclohexanecarboxylic Acids; D010169:Palmitic Acids