Intraspinal bleeding in haemophilia: successful treatment with factor VIII concentrate.
A severely affected haemophilic boy became tetraparetic as a result of a spontaneously occurring intraspinal haematoma. Myelography defined the extent of the lesion and showed it to be extradural in site. Infusion of large doses of factor VIII concentrate led to dramatic improvement and avoided the need to operate.
D000328:Adult; D005169:Factor VIII / Q000627:therapeutic use*; D006407:Hematoma, Epidural, Cranial / Q000000981:diagnostic imaging; D006467:Hemophilia A / Q000000981:diagnostic imaging* / Q000188:drug therapy; D006470:Hemorrhage / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D009192:Myelography; D013117:Spinal Cord Compression / Q000000981:diagnostic imaging; D013118:Spinal Cord Diseases / Q000000981:diagnostic imaging*
D005169:Factor VIII