Chronic lymphocytic leukemia--well-differentiated lymphocytic lymphoma with monoclonal IgA:IgA production by circulating lymphocytes.
A patient is described in whom morphologic features of well-differentiated lymphocytic lymphoma (WDL) or chronic lymphocytic leukemia (CLL) and immunologic features of multiple myeloma were present. Studies of isolated peripheral blood lymphocytes demonstrated de novo synthesis of IgA K, the same paraprotein that was identified in the serum. Predominant IgA synthesis by peripheral lymphocytes has not been previously shown in either WDL or CLL.
D006801:Humans; D007070:Immunoglobulin A / Q000096:biosynthesis*; D007945:Leukemia, Lymphoid / Q000150:complications*; D008214:Lymphocytes / Q000276:immunology*; D008223:Lymphoma / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications; D011947:Receptors, Antigen, B-Cell / Q000096:biosynthesis
D007070:Immunoglobulin A; D011947:Receptors, Antigen, B-Cell