title: Pharmacokinetics of fluoride in man after single and multiple oral doses.
abstract: The doses of fluoride (F) recommended in the literature for caries prevention and for the treatment of osteoporosis vary. This partly reflects inadequate knowledge of F pharmacokinetics. In the present study various single and multiple oral doses of F were given to eight volunteers, who had a strictly controlled F intake in the diet. The resulting plasma and parotid saliva concentrations as well as urinary output of F were measured. The plasma data fitted a two-compartment open model with a beta-slope half-life ranging between 2 and 9 h. Plasma clearance was 0.15+/-0.02 (SD) liter/kg/h. Data from the highest dose (10 mg) were fitted to both two- and three-compartment models, and there was no significant difference between them. Multiple doses of F 3.0 Or 4.5 mg yielded steady state concentrations ranging from 54 to 145 ng/ml. About 50 per cent of the given dose was recovered in the urine, which is indicative of considerable accumulation in the body. The saliva F/plasma F concentration ratio was 0.64 with a coefficient of variation of 5%.
mesh_terms: D000284:Administration, Oral; D000328:Adult; D005260:Female; D005459:Fluorides / Q000378:metabolism*; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D008954:Models, Biological; D012463:Saliva / Q000378:metabolism; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*
chemical_list: D012969:Sodium Fluoride; D005459:Fluorides