title: [The effect of tramadol on the EEG and the electronystagmogram (author's transl)].
abstract: 1-(m-Methoxyphenyl)-2-(dimethylaminomethyl)-cyclohexan-1-ol (tramadol; Tramal) in oral doses of 150 mg/kg caused no essential changes in the EEG pattern in man. Only the alpha-rhythm of the occipital leads was more synchronized and the amplitude somewhat higher. beta-Waves increased slightly, but the delta-waves were not significantly changed. Tramadol induced no measurable alterations in the electronystagmographic recordings of quick voluntary eye movements or follow-up to-and-fro eye movements. In the optokinetic and postrotatory nystagmus, however, there was a moderate decrease in the total amplitude and maximal angular velocity of the slow nystagmic stage. The results of EEG and electronystagmographic investigations indicate that tramadol has a moderate relaxant (central depressant) effect.
mesh_terms: D000328:Adult; D000700:Analgesics / Q000494:pharmacology*; D003511:Cyclohexanols / Q000494:pharmacology*; D004569:Electroencephalography; D004584:Electronystagmography; D004585:Electrooculography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D000700:Analgesics; D003511:Cyclohexanols
vernacular_title: Die Wirkung von Tramadol auf das Elektroenzephalogramm und Elektronystagmogramm.