title: Effect of the linoleic acid concentration of mother's diet on adenyl cyclase activity of fetal and neonatal rat brown adipose tissue.
abstract: An adenyl cyclase activity was measurable in the brown adipose tissue of fetal rat, and could be stimulated in vitro by noradrenaline during the last 3 days of fetal life. The stimulating effect of noradrenaline was maximal at birth and decreased during the first days of extrauterine life. Ingestion by mother of a high lipid diet modified the developmental pattern of fetal adenyl cyclase. The linoleic acid content of mother's diet had no effect on the noradrenaline- or fluoride-stimulated specific activities except on the day 22 of gestation. Relative noradrenaline-stimulated activity, expressed as a fraction of the maximal activity, was significantly increased in fetuses and 1-day-old newborns from mothers fed a high linoleic acid diet, but no effect was observed in suckling newborns.
mesh_terms: D000262:Adenylyl Cyclases / Q000378:metabolism*; D002001:Adipose Tissue, Brown / Q000187:drug effects / Q000201:enzymology*; D000818:Animals; D000831:Animals, Newborn; D004041:Dietary Fats; D005260:Female; D005333:Fetus; D005865:Gestational Age; D008041:Linoleic Acids / Q000494:pharmacology*; D008431:Maternal-Fetal Exchange; D009638:Norepinephrine / Q000494:pharmacology; D011247:Pregnancy; D051381:Rats
chemical_list: D004041:Dietary Fats; D008041:Linoleic Acids; D000262:Adenylyl Cyclases; D009638:Norepinephrine