The effect of oophorectomy on plasma oestrone and androstenedione levels in the rat.
Plasma oestrone and androstenedione levels have been measured in oophorectomized and sham-operated rats by means of radioimmunoassay. The mean oestrone level in the oophorectomized animals was approximately two-thirds of that in the intact animals while the androstendione levels were about half of those in the intact rats. A direct relationship was observed between the plasma oestrone and androstenedione levels in the control animals and to a lesser extent in the oophorectomized animals. The results indicate that approximately 50% of circulating androstenedione and 30% of circulating oestrone originate in the ovaries in the female adult rat.
D000735:Androstenedione / Q000097:blood*; D000818:Animals; D002369:Castration; D004970:Estrone / Q000097:blood*; D005260:Female; D011863:Radioimmunoassay; D051381:Rats
D004970:Estrone; D000735:Androstenedione