title: [Beclobrate and eniclobrate hydrochloride, new diphenylmethane derivatives as agents for lowering cholesterol and triglyceride levels. Part I: Synthesis and consideration of structure-activity relationships (author's transl)].
abstract: Within the course of a research project for finding new lipid-lowering substances with better therapeutic indices than the standard agent in use, various diphenylmethane derivatives were synthesized and tested with respect to their activity and toxicity. On the basis of these results Sgd 24774 (beclobrate) and Sgd 33374 (eniclobrate-hydrochloride) were selected for further investigation and clinical studies.
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000138:chemical synthesis*; D001559:Benzhydryl Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D000960:Hypolipidemic Agents / Q000138:chemical synthesis*; D007928:Lethal Dose 50; D008297:Male; D051381:Rats; D013329:Structure-Activity Relationship; D014280:Triglycerides / Q000097:blood*
chemical_list: D000924:Anticholesteremic Agents; D001559:Benzhydryl Compounds; D000960:Hypolipidemic Agents; D014280:Triglycerides
vernacular_title: Neue Cholesterin- und Triglyceridspiegel-senkende Dephenylmethan-Derivate, Beclobrat und Eniclobrat-hydrochlorid. 1. Mitteilung: Synthese und Betrachtungen über die Zusammenhänge zwischen Aktivität und Struktur.