The value of phenformin and ethyloestrenol in the prevention of deep venous thrombosis in patients undergoing surgery.
The effect of phenformin and ethyloestrenol on the incidence of post-operative deep venous thrombosis was studied in 314 surgical patients in a double-blind randomised trial. Although the laboratory tests suggested that the regime produced an increase in activators of the fibrinolytic system, the drugs used did not lower the incidence of post-operative deep venous thrombosis. Possible explanations of this paradox are advanced.
D005032:Ethylestrenol / Q000627:therapeutic use*; D005342:Fibrinolysis; D006801:Humans; D010629:Phenformin / Q000627:therapeutic use*; D010958:Plasminogen / Q000032:analysis; D011183:Postoperative Complications; D013924:Thrombophlebitis / Q000517:prevention & control* / Q000601:surgery*
D010958:Plasminogen; D005032:Ethylestrenol; D010629:Phenformin