Induction of aortic lipid deposition in a high-response (ExHC) rat fed a diet containing cholesterol and cholic acid.
Male ExHC and Sprague--Dawley rats were fed a diet containing 3% cholesterol, 0.6% sodium cholate and 15% olive oil for 16 weeks. The ExHC rat is highly susceptible to dietary hypercholesterolemia. Aortas of the ExHC rats showed Sudan-stained deposits and cholesterol accumulation in the intima and media, whereas no deposited lipids were seen in those of the Sprague--Dawley rats. In male and female ExHC rats fed diets containing the above supplements at 3 dose levels, plasma cholesterol and aortic lipid deposition were found to be dose-dependent. Lipid deposition was more prominent in female than in males, but aortic intimal proliferation was absent.
D000818:Animals; D001011:Aorta / Q000032:analysis / Q000473:pathology*; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D002793:Cholic Acids / Q000008:administration & dosage; D005260:Female; D006937:Hypercholesterolemia / Q000473:pathology*; D008055:Lipids / Q000032:analysis; D008099:Liver / Q000032:analysis; D008297:Male; D010743:Phospholipids / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains / Q000502:physiology*; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood
D002791:Cholesterol, Dietary; D002793:Cholic Acids; D008055:Lipids; D010743:Phospholipids; D014280:Triglycerides; D002784:Cholesterol