The effect of serotonin given into the lateral ventricle of the brain on serum TSH level in normal and thyroxine-blocked rats.
The effect of serotonin given into the lateral ventricle of the brain in rats was investigated. Serotonin was solved in artificial cerebrospinal fluid and administered in three doses: 250 microgram, 50 microgram, 10 microgram. Only the highest dose of serotonin caused a statistically significant increase in serum TSH level 0.5 h after the injection. The possible role of serotonin in the blocking mechanism of thyroid hormones on TSH secretion was also taken into consideration. 50 microgram of serotonin significantly strengthened the lowering effect of 1-thyroxine given 0.5 h before on serum TSH level.
D000818:Animals; D002552:Cerebral Ventricles; D005260:Female; D051381:Rats; D012701:Serotonin / Q000008:administration & dosage / Q000494:pharmacology*; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000378:metabolism
D012701:Serotonin; D013972:Thyrotropin; D013974:Thyroxine