In vitro evaluation of intraocular infusion fluids: effects on the lens and cornea.
Glutatione-bicarbonate-Ringer solution (GBR), GBR deficient in adenosine and glutathione, and a newly proposed glucose-phosphate-Ringer solution (GPR) have been found to maintain lens function and corneal endothelial viability with approximately equal efficacy during prolonged periods of incubation. Currently used intraocular irrigating solutions do not perform as well in maintaining the function of borderline decompensated lenses and in sustaining endothelial viability.
D000818:Animals; D001639:Bicarbonates / Q000008:administration & dosage / Q000494:pharmacology*; D002021:Buffers; D002387:Cataract Extraction; D003315:Cornea / Q000187:drug effects*; D004727:Endothelium / Q000187:drug effects; D005069:Evaluation Studies as Topic; D005947:Glucose / Q000494:pharmacology*; D005978:Glutathione / Q000008:administration & dosage / Q000494:pharmacology*; D007267:Injections; D007908:Lens, Crystalline / Q000187:drug effects*; D010710:Phosphates / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits; D012996:Solutions; D013997:Time Factors; D014822:Vitreous Body / Q000601:surgery
D001639:Bicarbonates; D002021:Buffers; D010710:Phosphates; D012996:Solutions; D005978:Glutathione; D005947:Glucose