1,2-Diphenylethylamines as potential non-stimulant anorectics.
A series of 1,2-diphenylethylamines has been synthesized in which the phenyl rings were substituted with Cl, OCH3 or CF3 at various positions and in various combinations. Four N-ethylpiperazino and N-ethylmorpholino compounds were also prepared. When tested in rats, some of the compounds were found to be potent anorectics and none of them stimulated motor activity.
D000818:Animals; D001067:Appetite Depressants / Q000138:chemical synthesis*; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010627:Phenethylamines / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats
D001067:Appetite Depressants; D010627:Phenethylamines