[Effect of sectioning the celiac and vagus nerves on the activity and isoenzymatic composition of rat liver lactate dehydrogenase].
Total activity of lactate dehydrogenase (LDH) was increased in rat liver cytoplasm after dissection of nervus celiacus; the enzyme activity was, however, decreased after section of nervus vagus. As showen by polyacrylamide gel electrophoresis the alterations in the enzyme activity occurred mainly due to changes in the isoenzyme LDH5, prevailing in this liver fraction. Administration of insulin did not restore the LDH activity, decreased after vagotomy. The suggestion is corroborated that the regulatory effects of sympathetic and parasympathetic nervous systems on glycolysis are of oppositely directed character.
D000818:Animals; D002447:Celiac Plexus / Q000502:physiology*; D003593:Cytoplasm / Q000201:enzymology; D004789:Enzyme Activation / Q000187:drug effects; D007328:Insulin / Q000494:pharmacology; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D008099:Liver / Q000201:enzymology* / Q000294:innervation; D008297:Male; D051381:Rats; D013562:Sympathectomy; D014630:Vagus Nerve / Q000502:physiology*
D007328:Insulin; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase
Vliianie pererezki chrevnykh i bluzhdaiushchikh nervov na aktivnost' i izofermentnyĭ sostav laktatdegidrogenazy pecheni krys.