title: Afterloading interstitial implant in the treatment of oral cavity and oropharyngeal cancers.
abstract: (1) In all, 70 patients with carcinoma of the oral cavity and oropharynx have been treated utilizing one or more of several interstitial iridium-192 afterloading techniques. (2) After an 18-month minimum follow-up period, local control is still maintained in 9 of 10 patients with T1 and T2 lesions (UICC), in 17 of 22 patients with T3 lesions, and in 21 of 38 patients reirradiated for recurrent disease. The complication rate of 29% in the reirradiated patients, though high, is considered acceptable in these essentially hopeless cases. (3) This preliminary report is made to stimulate interest in the role of interstitial iridium-192 afterloading techniques. We feel they deserve evaluation in a controlled study of other head and neck cancer management techniques (including external irradiation, surgical resection and adjunctive chemotherapy).
mesh_terms: D005500:Follow-Up Studies; D006801:Humans; D007495:Iridium / Q000008:administration & dosage* / Q000627:therapeutic use; D009062:Mouth Neoplasms / Q000532:radiotherapy*; D009364:Neoplasm Recurrence, Local; D010610:Pharyngeal Neoplasms / Q000532:radiotherapy*; D011868:Radioisotopes / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D011868:Radioisotopes; D007495:Iridium