[The effect of thyroid hormone on the absorption of L-proline, chloramphenicol and digitoxin].
Using the method of the perfused small intestine preparation in situ, the influence of triiodothyronine on the absorption was investigated. The absorptions of L-proline and digitoxin were disturbed by the thyroid hormone in different ways, in contrast to chloramphenicol, where it is unaltered. The effects of triiodothyronine on the absorption of these substances are dose dependently different. Obviously the thyroid hormone can influence the absorption of proline and digitoxin in both ways, increase or decrease. The behaviour of digitoxin different from that of chloramphenicol points to this drug making use of active mechanisms concerned in the absorption.
D000818:Animals; D002701:Chloramphenicol / Q000378:metabolism*; D004074:Digitoxin / Q000378:metabolism*; D066298:In Vitro Techniques; D007408:Intestinal Absorption / Q000187:drug effects*; D007421:Intestine, Small / Q000378:metabolism; D008297:Male; D011392:Proline / Q000378:metabolism*; D051381:Rats; D014284:Triiodothyronine / Q000494:pharmacology*
D014284:Triiodothyronine; D002701:Chloramphenicol; D011392:Proline; D004074:Digitoxin
Wirkung des Schilddrüsenhormons auf die Resorption von L-Prolin, Chloramphenicol und Digitoxin.