Effects of alpha- and beta-adrenergic receptor blockade on the isoamylases of rat-parotid gland.
The in vivo activity of rat-parotid isoamylases was increased following alpha-receptor block by phentolamine. Additional inhibition of the beta-receptors by propranolol did not further augment the isoenzyme activities. After 21 days, the isoamylase concentrations were even lower than after alpha-receptor block alone. Based upon these results, an alpha-receptor mediated discharge from the duct system of already secreted gland protein and a possible role of the alpha-receptors in protein secretion from the parotid gland are discussed.
D000818:Animals; D005260:Female; D006026:Glycoside Hydrolases / Q000378:metabolism*; D007517:Isoamylase / Q000378:metabolism*; D010306:Parotid Gland / Q000187:drug effects / Q000201:enzymology*; D010646:Phentolamine / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology; D051381:Rats
D011433:Propranolol; D006026:Glycoside Hydrolases; D007517:Isoamylase; D010646:Phentolamine