Inhibitory effect of enkephalins on contractions of the guinea-pig ileum elicited by PGE1.
Methionine-enkephalin and leucine-enkephalin (m-enk and 1-enk) as well as D-Ala2-methionine-enkephalin amide have been shown to antagonize contractions of the isolated guinea-pig intestine elicited by PGE1, the last mentioned being the most potent of the three. The inhibitory effect of these pentapeptides is abolished by naloxone.
D000818:Animals; D004723:Endorphins / Q000494:pharmacology*; D004745:Enkephalins / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D009270:Naloxone / Q000494:pharmacology; D011458:Prostaglandins E / Q000037:antagonists & inhibitors* / Q000494:pharmacology
D004723:Endorphins; D004745:Enkephalins; D011458:Prostaglandins E; D009270:Naloxone