Central effect of 5,8,11,14-eicosatetraenoic acid (arachidonic acid) on the temperature in the conscious rabbit.
Hyperthermia induced by arachidonic acid in rabbit was attenuated by phenoxybenzamine, cyproheptadine and indomethacin. The reduction in arachidonic acid hyperthermia, after 6-OH-DA and the failure of PCPA to reduce this rise, indicates the involvement of noradrenaline in arachidonic acid hyperthermia.
D000818:Animals; D001095:Arachidonic Acids / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D001831:Body Temperature / Q000187:drug effects*; D003533:Cyproheptadine / Q000494:pharmacology; D005334:Fever / Q000139:chemically induced; D006892:Hydroxydopamines / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D010643:Phenoxybenzamine / Q000494:pharmacology; D011817:Rabbits
D001095:Arachidonic Acids; D006892:Hydroxydopamines; D010643:Phenoxybenzamine; D003533:Cyproheptadine; D007213:Indomethacin