Influence of essential amino acids and keto acids on protein metabolism and the anaemia of patients on chronic intermittent haemodialysis.
Ten patients were treated with 10 g essential amino acids per day orally; 9 patients received 9.5 g of a mixture of essential amino acids (Lys, Thr, Try, His, Tyr) and ketoanalogues of Ile, Leu, Phe, Val, Met per day and a control group of 11 patients received no supplementation. All patients were on a liberal food intake amounting to 1g protein/kg body weight and 31 kcal/kg body weight daily. Before and three months after the beginning of supplementation the following parameters were measured: serum concentrations of albumin, transferrin, urea, creatinine, blood haemoglobin content and haematocrit, activities of the enzymes delta-aminolevulinic acid dehydrase and porpho-bilinogen desaminase, and globin synthesis in peripheral red blood cells. After treatment with either essential amino acids or keto acids a significant stimulation of globin synthesis occurred. None of the other parameters was altered. It is concluded that in well-nourished patients supplements of essential amino acids or keto acids are ineffective.
D000601:Amino Acids, Essential / Q000627:therapeutic use*; D000740:Anemia / Q000209:etiology / Q000378:metabolism / Q000628:therapy*; D003404:Creatinine / Q000097:blood; D004044:Dietary Proteins / Q000008:administration & dosage; D005914:Globins / Q000096:biosynthesis; D006801:Humans; D007651:Keto Acids / Q000627:therapeutic use*; D011506:Proteins / Q000378:metabolism*; D006435:Renal Dialysis; D012709:Serum Albumin / Q000032:analysis; D014168:Transferrin / Q000032:analysis; D014508:Urea / Q000097:blood; D014511:Uremia / Q000150:complications* / Q000628:therapy
D000601:Amino Acids, Essential; D004044:Dietary Proteins; D007651:Keto Acids; D011506:Proteins; D012709:Serum Albumin; D014168:Transferrin; D014508:Urea; D005914:Globins; D003404:Creatinine