Non-specific prostaglandin antagonism by 8-ethoxycarbonyl-5-methyl-10, 11-dihydro-PGA1-ethyl ester (HR 546) on some smooth muscle preparations in vitro.
The ability of 8-ethoxycarbonyl-10, 11 dihydro-A-prostaglandin(HR 546) to antagonise smooth muscle contracting effect of prostaglandins E2 and F2alpha on isolated preparations of rat and hamster stomach fundus, guinea pig ileum and gerbil colon has been studied. HR 546 was found to be a potent, non-specific, probably competitive, prostaglandin antagonist on these four smooth muscle preparations.
D000818:Animals; D003106:Colon / Q000187:drug effects; D006224:Cricetinae; D005849:Gerbillinae; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D011448:Prostaglandin Antagonists / Q000494:pharmacology*; D011455:Prostaglandins A, Synthetic / Q000494:pharmacology*; D011458:Prostaglandins E / Q000494:pharmacology; D011460:Prostaglandins F / Q000494:pharmacology; D051381:Rats; D013270:Stomach / Q000187:drug effects
D011448:Prostaglandin Antagonists; D011455:Prostaglandins A, Synthetic; D011458:Prostaglandins E; D011460:Prostaglandins F