[Chloroquine enantiomers. Activity against P. vinckei and binding on DNA (author's transl)].
(+)-Chloroquine is more active against P. vinckei than (-)-chloroquine. No correlation has been observed between antiplasmodial activity and DNA-binding of the chloroquine enantiomers.
D000962:Antimalarials; D002738:Chloroquine / Q000378:metabolism / Q000494:pharmacology*; D004269:DNA, Bacterial / Q000378:metabolism*; D010961:Plasmodium / Q000187:drug effects; D013237:Stereoisomerism
D000962:Antimalarials; D004269:DNA, Bacterial; D002738:Chloroquine
Chloroquin-Enantiomere. Wirkung gegen Nagetiermalaria (P. vinckei) und Bindung an DNS.