title: [Chronic infection of cells with tick-borne encephalitis virus. Additional characteristics of the provirus].
abstract: The paper presents additional characteristics of HEp-2 cells cronically infested with tick-borne encephalitis virus, Sofyin strain (Hep-2-Sof). On the basis of the inhibition analysis, the method of molecular hybridization, and transfection, HEp-2-Sof cells were shown to contain dozens of DNA-transcripts of tick-borne encephalitis virus integrated into nucleoplasm DNA and into the fraction of repeated sequences. Their transcription is mediated by a polymerase sensitive to L-amanitine.
mesh_terms: D000547:Amantadine / Q000494:pharmacology; D002460:Cell Line; D002999:Clone Cells; D004247:DNA; D003609:Dactinomycin / Q000494:pharmacology; D004669:Encephalitis Viruses, Tick-Borne / Q000235:genetics; D009693:Nucleic Acid Hybridization; D012367:RNA, Viral; D014158:Transcription, Genetic / Q000187:drug effects; D014162:Transfection; D014779:Virus Replication / Q000187:drug effects
chemical_list: D012367:RNA, Viral; D003609:Dactinomycin; D004247:DNA; D000547:Amantadine
vernacular_title: Khronicheskaia infektsiia kletok virusom kleshchevogo éntsefalita. Doponitel'naia kharakteristika provirusa.