Incidence of decompression-induced pulmonary haemorrhage in young and old rats.
Seventeen young rats (40-52 days of age) and 17 old rats (545-702 days of age) were decompressed from one atmospheric pressure to an ambient pressure of 30 mmHg in 0.25 second. It was found that 11 of 34 young lungs (32%) and 23 of 34 old lungs (68%) showed decompression-induced pulmonary haemorrhage. The difference was statistically significant. The pulmonary haemorrhage of the old rats was markedly more severe than that of the young rats.
D000375:Aging; D000818:Animals; D003664:Decompression / Q000009:adverse effects*; D006470:Hemorrhage / Q000453:epidemiology / Q000209:etiology*; D008171:Lung Diseases / Q000453:epidemiology / Q000209:etiology*; D011312:Pressure / Q000009:adverse effects*; D051381:Rats