Corticosteroid response in dominant congenital glaucoma.
The parents of six children with goniodysgenesis and hereditary infantile congenital glaucoma were tested with corticosteroid eye-drops. Their response on provocation demonstrated a clear trend: In five families one parent of each couple responded with a tensional rise of 9 mmHg or more, whereas the other parent responded with a rise of 9 mmHg or less. Of the six parents with the greater response, five had glaucoma in their ancestry and displayed a distinct goniodysgenesis. The findings support the previously presented view that hereditary infantile congenital glaucoma is caused by a dominant goniodysgenesis with varying expressively. The high corticosteroid response in the families of our study appears to be correlated to this goniodysgenesis. The inherited corticosteroid response is obviously not a specific genetic trait confined to families with simple glaucoma.
D000293:Adolescent; D002648:Child; D003907:Dexamethasone; D005260:Female; D005901:Glaucoma / Q000175:diagnosis* / Q000235:genetics; D006068:Gonioscopy; D006801:Humans; D007223:Infant; D008297:Male; D010375:Pedigree; D014065:Tonometry, Ocular
D003907:Dexamethasone