Liposolubility as an aspect of nitrosamine carcinogenicity: quantitative correlations and qualitative observations.
Carcinogenicity data for a number of nitrosamines have been examined for possible structure-activity correlations with liposolubility by the method of Hansch. Correlations were found in two cases which support a previous mechanistic suggestion and which also suggest a possible difference between the action of nitrosopiperidines and dinitrosopiperazines in inducing olfactory carcinomas. No correlations were found for non-cyclic nitrosamines.
D000438:Alcohols; D000818:Animals; D005260:Female; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D009602:Nitrosamines; D051381:Rats; D012995:Solubility; D013329:Structure-Activity Relationship
D000438:Alcohols; D009602:Nitrosamines