[The influence of benzarone on the polidocanol and thiopental induced edemas in the hind-limb of the cat (author's transl)].
In chloralose-anesthetized cats, a hind-limb was perfused at constant flow and the vascular endothelium was made permeable for protein by intravascular injection of polidocanol and thiopental. Besides parameters of circulation and the transcapillary fluid exchange the contents of plasma protein and water were measured in skin and muscle tissue of the edematous hind-limb as well as in the contralateral untreated hind-limb. Benzarone, 2.5 mg/kg i.v., inhibited the development of the protein edemas when injected before the application of the edema producing substances. In polidocanol and thiopental-induced edemas--except for the thiopental-induced skin edema that was less marked even in the controls--benzarone had a significant effect.
D000818:Animals; D001572:Benzofurans / Q000627:therapeutic use*; D001798:Blood Proteins / Q000378:metabolism; D002415:Cats; D004487:Edema / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control*; D009132:Muscles / Q000503:physiopathology; D011092:Polyethylene Glycols / Q000494:pharmacology*; D012867:Skin / Q000503:physiopathology; D013874:Thiopental / Q000494:pharmacology*
D001572:Benzofurans; D001798:Blood Proteins; D011092:Polyethylene Glycols; D013874:Thiopental
Uber den Einfluss des Benzarons auf das Polidocanol- und Thiopental-Odem am Hinterlauf der Katze.