The gastrointestinal and autonomic effects of 3-methyl-5,6,7,8-tetrahydroquinoline-8-thiocarboxamide hydrochloride (tiquinamide).
3-Methyl-5,6,7,8-tetrahydroquinoline-8-thiocarboxamide hydrochloride (tiquinamide), a potent gastric anti-secretory compound, affords good protection against stress- and chemically-induced gastric and duodenal erosions. It causes a dose-related delay in gastric emptying and intestinal transit, and does not have a primary effect on gastric mucosal blood flow. The only actions of tiquinamide on the peripheral autonomic nervous system are weak, but apparently specific, histamine H2-receptor blocking activity, and non-competitive inhibition of acetylcholine and histamine responses at 10(-3) mol/l. Since no other effect on isolated tissues can be detected, it seems unlikely that the antisecretory action of tiquinamide involves a direct action on the peripheral autonomic nervous system.
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D001341:Autonomic Nervous System / Q000187:drug effects*; D003847:Deoxyglucose / Q000494:pharmacology; D004064:Digestive System / Q000187:drug effects*; D004837:Epinephrine / Q000494:pharmacology; D005753:Gastric Mucosa / Q000098:blood supply; D005769:Gastrointestinal Motility / Q000187:drug effects; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects; D011804:Quinolines / Q000494:pharmacology*; D051381:Rats; D012039:Regional Blood Flow / Q000187:drug effects; D012701:Serotonin / Q000494:pharmacology; D012882:Skin Tests
D000897:Anti-Ulcer Agents; D011804:Quinolines; D012701:Serotonin; D006632:Histamine; D003847:Deoxyglucose; D004837:Epinephrine