title: Compared effects of irradiation and cyclophosphamide induced erythroid aplasia on the catabolism of exogenous erythropoietin.
abstract: The effect of erythroid aplasia on the clearance rate of exogenous erythropoietin from the circulation has been studied in irradiated (200, 400 and 800 r) and cyclophosphamide (50 mg/kg) treated rats. After irradiation, the T1/2 was increased from 1.5 h in controls to 2.3 h. In spite of similar aplasia, the T1/2 observed after cyclophosphamide administration was identical to the T1/2 in controls. These results suggest that the action of X-rays on the catabolism of erythropoietin is independent of erythroid aplasia and could be related to an extramedullary effect of irradiation.
mesh_terms: D000741:Anemia, Aplastic / Q000378:metabolism; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000528:radiation effects; D001854:Bone Marrow Cells; D003520:Cyclophosphamide / Q000494:pharmacology*; D004921:Erythropoietin / Q000378:metabolism*; D006207:Half-Life; D008297:Male; D011830:Radiation Effects; D051381:Rats
chemical_list: D004921:Erythropoietin; D003520:Cyclophosphamide