The forced end-expiratory flow rate in chloromethyl ether workers.
Spirograms were made in 103 chemical workers, 72 of whom had been exposed for years to chloromethyl ethers to various degrees. The end-expiratory flow rate was below 60% of predicted in one-third of exposed men compared to only 3% of unexposed men. Smoking was a confounding factor. In 49 current cigarette smokers consuming less than one pack per day, the data suggested a dose-response relationship between chemical exposure and the frequency of low end-expiratory flow rate.
D001725:Bis(Chloromethyl) Ether; D002617:Chemical Industry; D004305:Dose-Response Relationship, Drug; D004781:Environmental Exposure; D005540:Forced Expiratory Flow Rates; D006801:Humans; D008297:Male; D008738:Methyl Ethers; D009787:Occupational Medicine; D012907:Smoking / Q000503:physiopathology
D008738:Methyl Ethers; D001725:Bis(Chloromethyl) Ether