Effects of a new diuretic on cerebrospinal fluid pressure in patients with supratentorial tumors.
The effect of a new, powerful diuretic on biochemical parameters, urine output, central venous pressure, blood pressure, and cerebrospinal fluid pressure in patients with supratentorial intracerebral tumors who showed signs and symptoms of increased intracranial pressure was tested. When compared to an untreated control group and to the steady-state data of each patient, CSF pressure was significantly reduced using a dose of 240 mg of the diuretic. The 120 mg dosage did not produce significant results. Normalization of increased cerebrospinal fluid pressure was not completely obtained using either dose. Used alone, this substance is not suitable for treatment of increased intracranial pressure due to brain edema in patients with intra-cerebral tumors. It might, however, be useful in combination with other medications.
D001929:Brain Edema / Q000134:cerebrospinal fluid / Q000188:drug therapy; D001932:Brain Neoplasms / Q000134:cerebrospinal fluid*; D004232:Diuretics / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007427:Intracranial Pressure / Q000187:drug effects*; D011720:Pyrazoles / Q000627:therapeutic use*
D004232:Diuretics; D011720:Pyrazoles