Synthesis of carboxyarylindoles and benzofurans as nonsteroidal antiinflammatory agents.
2-Carboxyaryl-substituted dihydrobenz[e]indoles, tetrahydroindoles, and tetrahydrobenzofurans have been synthesized as structural analogues of fendosal, a new antiinflammatory agent, and tested in the carrageenan-induced rat paw edema assay. Two of these, 2-(3-carboxy-4-hydroxyphenyl)-3-phenyl-4,5-dihydrobenz[e]indole and 1-(n-butyl)-2-(3-carboxy-4-hydroxyphenyl)-4,5,6,7-tetrahydroindole, were found to have significant activity, albeit of a lower order than fendosal.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis*; D001572:Benzofurans / Q000138:chemical synthesis* / Q000494:pharmacology; D004487:Edema / Q000503:physiopathology; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D051381:Rats; D013329:Structure-Activity Relationship
D000893:Anti-Inflammatory Agents; D001572:Benzofurans; D007211:Indoles