title: The effect of certain antiplatelet drugs on in vitro malonylaldehyde (MDA) production.
abstract: Several antiaggregating agents were tested with regard to their effect on platelet malonylaldehyde (MDA) production which seems to be a good marker of prostaglandin metabolism. Non-steroidal antiinflammatory compounds, namely acetylsalicylic acid (ASA), ditazole and sulfinpyrazone, showed a sure, statistically significant, inhibitory effect on MDA production while theophylline, adenosine and alpha-blocking agent nycergoline did not. Dipyridamole on the contrary, was demonstrated to have a mild but still statistically significant effect on the inhibition of platelet MDA production.
mesh_terms: D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D008314:Malonates / Q000097:blood*; D008315:Malondialdehyde / Q000097:blood*; D010974:Platelet Aggregation / Q000187:drug effects*
chemical_list: D008314:Malonates; D008315:Malondialdehyde