[Breast cancer: limited excision followed by irradiation. Results and therapeutic indications in 150 cases treated at the Curie Foundation in 1960-1970].
The authors studies 150 cases of mammary cancer treated at La Fondation Curie between 1960 and 1970 by lumpectomy followed by irradiation. At the 5th year the survival rate without recurrence is 85 p. 100 (128 out of 150 cases) and is 72 p. 100 (56 out of 78) at the 10th year. There were 17 local/regional recurrences in the first 5 years, say 11 p. 100, of which one was supraclavicular and one "acute". Of the 15 cases operated on 7 are alive without sign of recurrence at more than 5 years. Satisfactory conservation of the breast has been achieved since in the 128 cured patients the breast was preserved 123 times (96%). In the 78 cases followed for 10 years there were 13 local/regional recurrences, say 17 p. 100, of which one was "acute". In the 56 cured cases the breast was preserved in 49 (87%). The combination of lumpectomy/irradiation seems to be a viable therapeutic modality but with these limitations: 1. That the diagnosis of carcinoma should be pre- or per-operative and the lumpectomy generous. 2. That the radiotherapy dosage should be relatively moderate. 3. That the indications be strictly adhered to--only treat tumours less than 3 cm, taking due note of the respective volumes of tumour and breast without apparent involvement of axillary nodes. If these conditions are adhered to the results are good both aesthetically and curatively.
D001943:Breast Neoplasms / Q000532:radiotherapy / Q000601:surgery*; D006801:Humans; D008207:Lymphatic Metastasis / Q000532:radiotherapy; D008408:Mastectomy; D009364:Neoplasm Recurrence, Local; D011182:Postoperative Care; D012189:Retrospective Studies
Cancers du sein : exérèse limitée suivie d'irradiation. Résultats et indications thérapeutiques à propos de 150 cas traités à la Fondation Curie de 1960 à 1970.