Structure of two glycoasparagines isolated from the urine of patients with aspartylglycosylaminuria (AGU).
The structures of two glycoasparagines composed of one mole each of N-acetylneuraminic acid, galactose, N-acetylglucosamine, and asparagine were determined by periodate oxidation, enzymatic degradation, and methylation analysis. The structures were NANAalpha2 leads to 3Galbeta1 leads to 4GlcNAcbeta leads to Asn and NANAalpha2 leads to 6Galbeta1 leads to 4GlcNAcbeta leads to Asn, respectively.
D001216:Asparagine / Q000031:analogs & derivatives* / Q000652:urine; D002241:Carbohydrates / Q000032:analysis; D002849:Chromatography, Gas; D006801:Humans; D007700:Kinetics; D008661:Metabolism, Inborn Errors / Q000652:urine*; D009439:Neuraminidase / Q000378:metabolism; D009844:Oligosaccharides / Q000652:urine*
D002241:Carbohydrates; D009844:Oligosaccharides; D001216:Asparagine; D009439:Neuraminidase