[Hormonal regulation of the electrical properties of the cell membrane].
Experiments were conducted on rats; it was shown that insulin, adrenaline, hydrocortisone, somatotropin, estradioldipropionate, deoxycorticosteroneacetate caused a rise of the membrane potential of individual muscle fibers, hepatocytes, motor neurons of the spinal cord, critical depolarization threshold, membrane resistance, shifts, in the K+, Na+ content. Simultaneously with these changes of the electrical properties of the membrane there occurred a rise of the RNA fraction synthesis, transcribing capacity of chromatin. Inhibitors of protein biosynthesis (actinomycin D, olivomycin, X-irradiation) prevented the hyperpolarization development and activation of genetic apparatus, whereas energy metabolsim inhibitors (sodium fluoride, monoiodine acetate, 2,4-dinitrophenol) failed to influence the rise of the membrane potential caused by hormones. Shifts in the electrical properties of cell membranes caused by hormones are connected with the genetic apparatus activation.
D000818:Animals; D000963:Antimetabolites / Q000494:pharmacology; D002462:Cell Membrane / Q000502:physiology*; D003609:Dactinomycin / Q000494:pharmacology; D003900:Desoxycorticosterone / Q000502:physiology; D004553:Electric Conductivity; D004594:Electrophysiology; D004837:Epinephrine / Q000502:physiology; D004958:Estradiol / Q000502:physiology; D013006:Growth Hormone / Q000502:physiology; D006728:Hormones / Q000502:physiology*; D006854:Hydrocortisone / Q000502:physiology; D007328:Insulin / Q000502:physiology; D008564:Membrane Potentials / Q000187:drug effects / Q000528:radiation effects; D051381:Rats
D000963:Antimetabolites; D006728:Hormones; D007328:Insulin; D003609:Dactinomycin; D003900:Desoxycorticosterone; D004958:Estradiol; D013006:Growth Hormone; D006854:Hydrocortisone; D004837:Epinephrine
Gormonal'naia reguliatsiia élektricheskikh svoĭstv membrany kletki.