Thermography as a tool for evaluating the local tolerance of i.m. administration of drugs.
Until today the local tolerance of i.m. administration of various drugs has been possible to register only by asking the patients about their subjective feelings. In this study using a new galenic form of trimethoprim/sulfamethoxazol (Bactrim) developed for i. m. administration and ampicillin we could find that thermography can be used as a very exact method to measure the local tolerance of i.m. administered drugs. In fact, the thermography gave reaction before the patient reported any pain and in cases where pain existed the thermography findings correlated well with the reports of the test persons.
D000328:Adult; D000368:Aged; D000667:Ampicillin / Q000008:administration & dosage; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D013420:Sulfamethoxazole / Q000008:administration & dosage; D013817:Thermography; D014295:Trimethoprim / Q000008:administration & dosage
D004338:Drug Combinations; D000667:Ampicillin; D014295:Trimethoprim; D013420:Sulfamethoxazole