title: [The course of asymptomatic diabetes under varying preventive therapy--concluding report of a 5-year prospective study].
abstract: During a prospective study the course of asymptomatic diabetes in different preventive treatment (diet, additionally tolbutamide, carbutamide or buformin) was observed concerning the frequency of manifestation and the behaviour of the oral glucose tolerance. Among the 100 protodiabetics after 5 years 38 clinical manifestations could be established, which finally nearly equally were distributed to all 4 groups of treatment. Only under the influence of buformin an effect preventing manifestation limited to 2 years appeared. Patients with persisting full or partial remissions continuously and more decreased in weight than cases of manifestation. Furthermore, the course was determined by the initially existing degree of hyperglycaemia as well as by the improvement of the glucose tolerance achieved in the first year. On account of the results of the examinations and the existing literature a preventive use of oral antidiabetics cannot be recommended.
mesh_terms: D002026:Buformin / Q000627:therapeutic use; D002271:Carbutamide / Q000627:therapeutic use; D003920:Diabetes Mellitus / Q000503:physiopathology* / Q000517:prevention & control / Q000628:therapy; D003927:Diet, Diabetic; D005260:Female; D005859:Germany, East; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014044:Tolbutamide / Q000627:therapeutic use
chemical_list: D014044:Tolbutamide; D002271:Carbutamide; D002026:Buformin
vernacular_title: Verlauf des asymptomatischen Diabetes bei untershiedlicher Präventivbehandlung - Abshlussbericht einer 5jährigen prospektiven Studie.