Effects of cicloxilic acid on secretory function of the liver. I. Effect on bile flow and on biliary secretion of bilirubin and glucuronic acid in anesthetised bileduct-cannulated rat.
Both in normal and experimentally jaundiced rats cis-2-hydroxy-2-phenyl-cyclohexanecarboxilic acid (cicloxilic acid) induces a greater and longer lasting increase in bile flow and a greater increase in bilirubin and glucuronic acid secretion than do the choleretics sodium 2-(2-hydroxy-3n hexoxy-propoxy)-benzoate and dehydrocholic acid. The intense increase in bilirubin secretion is interpreted as the outcome of stimulation of the biliary secretion mechanisms whilst the effect on bile flow and on the biliary secretion of glucuronic acid are attributed to the kinetics of biliary secretion of cicloxilic acid.
D000758:Anesthesia; D000818:Animals; D001565:Benzoates / Q000494:pharmacology; D001646:Bile / Q000378:metabolism*; D001663:Bilirubin / Q000378:metabolism*; D003509:Cyclohexanecarboxylic Acids / Q000494:pharmacology*; D003685:Dehydrocholic Acid / Q000494:pharmacology; D005965:Glucuronates / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051381:Rats; D013997:Time Factors
D001565:Benzoates; D003509:Cyclohexanecarboxylic Acids; D005965:Glucuronates; D003685:Dehydrocholic Acid; D001663:Bilirubin