[Component composition and admixtures of related compounds in commercial preparations with an erythromycin base].
Chromatographic purity of erythromycin base preparations manufactured in the USSR with various technological procedures and those of 4 foreign firms was studied. All the preparations studied in addition to the main component of erythromycin A contained 5 to 7 per cent of erythromycin C and about 1.5 to 3.5 per cent of a non-identified component possessing a somewhat lower chromatographic mobility than erythromycin C. The admixture of 0.5--1 per cent of anhydroerythmycin was found in many erythromycin preparations. The preparations of some foreign firms contained also a number of additional substances. It was shown that the antimicrobial activity of anhydroerythromycin was 50-60 times lower than that of erythromycin. Direct correla;ion between the level of the antimicrobial activity of the market prepaetions of erythromycin and the level of its chemical purity was noted.
D000818:Animals; D002855:Chromatography, Thin Layer; D004917:Erythromycin / Q000031:analogs & derivatives / Q000032:analysis* / Q000633:toxicity; D051379:Mice
D004917:Erythromycin
Kompenentnyĭ sostav i primesi rodstvennykh soedineniĭ v tovarnykh preparatakh éritromitsina osnovaniia.