Plasma renin activity and plasma aldosterone concentration in infants with various sodium intakes.
Plasma renin activity (PRA) and plasma aldosterone concentration (PA) were measured in 20 healthy infants 2-12 months of age, after taking a commercial modified cow's milk formula with 8.2 mmol/l sodium for at least five days, and after at least five days on a home-made, undiluted acidified cow's milk formula with 12.6 mmol/l sodium. The mean sodium intakes were 1.20 and 1.87 mmol/kg of body weight per day respectively. The arithmetic means for the corresponding PRA were 6.16 and 1.08 ng/ml . h (difference not significant) and the corresponding arithmetic means for PA were 603 and 355 pg/ml, the difference being highly significant (P less than 0.01). It is concluded that one has to consider the sodium intake in the milk formula when studying plasma aldosterone in infancy.
D000450:Aldosterone / Q000097:blood*; D000818:Animals; D005260:Female; D006801:Humans; D007223:Infant; D007225:Infant Food / Q000032:analysis*; D008297:Male; D008433:Mathematics; D008892:Milk / Q000032:analysis; D012083:Renin / Q000097:blood*; D012964:Sodium / Q000008:administration & dosage* / Q000032:analysis
D000450:Aldosterone; D012964:Sodium; D012083:Renin