Inhibition of specific immune responses by feeding protein antigens.
A profound and long-lasting state of specific immune unresponsiveness may be induced in adult inbred mice given a single dose of protein immunogens--such as ovalbumin or hemocyanin--by the digestive route. The degree of unresponsiveness induced by intragastric exposure to ovalbumin could not be achieved by intravenous injection of deaggregated ovalbumin solutions across a wide range of doses. Unresponsiveness induced by intragastric exposure to hapten-protein conjugates is specific to the carrier protein.
D000284:Administration, Oral; D000818:Animals; D000917:Antibody Formation; D000941:Antigens / Q000008:administration & dosage*; D004136:Dinitrobenzenes / Q000008:administration & dosage; D005260:Female; D006433:Hemocyanins / Q000008:administration & dosage; D007108:Immune Tolerance; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007441:Intubation, Gastrointestinal; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D010047:Ovalbumin / Q000008:administration & dosage; D010059:Ovomucin / Q000008:administration & dosage
D000941:Antigens; D004136:Dinitrobenzenes; D010059:Ovomucin; D010047:Ovalbumin; D006433:Hemocyanins