A comparison of Ludiomil, Tryptizol and Lentizol.
One hundred and seventy-six patients were admitted to an open, multicentre, comparative trial of Ludiomil, Tryptizol SR and Lentizol, each administered in a dose of 75 mg at night. Fifty-seven patients received Tryptizol SR, 60 received Lentizol and 59 received Ludiomil. Nine patients on Tryptizol SR, 10 patients on Lentizol and 6 patients on Ludiomil dropped out for a variety of reasons. A seventeen-symptom rating scale was used and the symptoms analyzed individually. A greater response in the severity and number of symptoms was seen in the first week of treatment on Ludiomil though the differences rarely reached the acceptable level of statistical significance. Global assessments did not reveal any differences between the groups. Side-effects were also similar. Only dry mouth and drowsiness were persistent problems.
D000328:Adult; D000639:Amitriptyline / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000873:Anthracenes / Q000627:therapeutic use*; D003692:Delayed-Action Preparations; D003863:Depression / Q000188:drug therapy*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008376:Maprotiline / Q000009:adverse effects / Q000627:therapeutic use*
D000873:Anthracenes; D003692:Delayed-Action Preparations; D000639:Amitriptyline; D008376:Maprotiline