Anticonvulsant action of thiabendazole.
Thiabendazole was found to be specifically effective against maximal electroshock seizures in albino rats. It produced a significant dose-dependent decrease in the duration of the tonic extensor phase of hind legs. The ED50 was similar for oral or s.c. administration. PTZ-induced convulsions were unaffected by lower doses but aggravated by the higher dose studied.
D000818:Animals; D000927:Anticonvulsants; D004597:Electroshock; D008297:Male; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D051381:Rats; D013827:Thiabendazole / Q000494:pharmacology*
D000927:Anticonvulsants; D013827:Thiabendazole; D010433:Pentylenetetrazole