Elimination of cardiac glycosides through hemofiltration.
Elimination of three different cardiac glycosides by hemofiltration was investigated using the flat bed RP-6 (Rhône-Poulenc, Paris). At a filtration rate of 59 +/- 9 ml/min the mean clearance of 3-H-g-strophanthin was 54.9 +/- 10.4, that of a 3-H-digoxin and unlabelled digoxin 36.7 +/- 6.6 and that of digitoxin 4.6 +/- 2.8 ml/min. It is concluded from these results that hemofiltration is able to eliminate more than 50% of the amount excreted during the same period of time by normal kidneys. Elimination of cardiac glycosides by continuous hemofiltration is high enough to justify its use in digitalis intoxication, particularly because of the excellent control of electrolyte balance with this new method of detoxification.
D002301:Cardiac Glycosides; D004074:Digitoxin / Q000097:blood; D004077:Digoxin / Q000097:blood; D005374:Filtration; D006801:Humans; D007668:Kidney / Q000502:physiology; D007688:Kidneys, Artificial; D006435:Renal Dialysis; D013328:Strophanthins / Q000097:blood
D002301:Cardiac Glycosides; D013328:Strophanthins; D004077:Digoxin; D004074:Digitoxin