title: Anticoccidial activity of salinomycin in battery raised broiler chickens.
abstract: Infections with single species of Eimeria acervulina, E. mivati, E. maxima, E. tenella, E. necatrix, and E. brunetti, and the six species mixed, were utilized in three separate battery experiments to evaluate the anticoccidial efficacy of various levels of salinomycin (AHR-3096), a fermentation product of a strain of Streptomyces albus. At the 60 to 100 p.p.m. treatment levels, this compound showed significant anticoccidial activity for all parameters studied (mortality, weight gain, feed conversion, dropping scores, and lesion scores). The mortality due to coccidiosis was reduced to 0.1% in the medicated infected birds. Some activity, as measured by weight gain, was seen in the lower levels of salinomycin medication (12.5 to 50 p.p.m.), but other parameters, including mortality and lesion scores, indicated less activity than that seen with the higher treatment levels. At 100 p.p.m., there was no apparent effect on the compound on bird performance in uninfected control birds. Salinomycin at the 100 p.p.m. treatment level was statistically as effective as 121 p.p.m. monensin (reference anticoccidial) in controlling coccidiosis.
mesh_terms: D000821:Animal Feed; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001835:Body Weight; D002645:Chickens; D003048:Coccidiosis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D003049:Coccidiostats / Q000627:therapeutic use*; D007422:Intestines / Q000473:pathology; D008985:Monensin / Q000627:therapeutic use; D011201:Poultry Diseases / Q000188:drug therapy* / Q000473:pathology; D011714:Pyrans / Q000627:therapeutic use; D000095662:Polyether Polyketides
chemical_list: D000900:Anti-Bacterial Agents; D003049:Coccidiostats; D008985:Monensin; D011714:Pyrans; C010327:salinomycin; D000095662:Polyether Polyketides