title: The neurological basis of motor asymmetry following unilateral 6-hydroxydopamine brain lesions in the rat: the effect of motor decortication.
abstract: The role of the motor cortex in the mediation of asymmetric movement after unilateral 6-hydroxydopamine (6-OHDA) brain lesions has been examined in the rat. The effect of unilateral and bilateral sensorimotor decortication upon spontaneous and drug (apomorphine and amphetamine)-induced motor asymmetry has been studied following unilateral injection of 6-OHDA into the lateral hypothalamus. Both bilateral decortication and unilateral decortication on the side of the 6-OHDA lesion caused a transient reversal of the spontaneous motor asymmetry normally seen in 6-OHDA lesioned animals. Neither unilateral nor bilateral sensorimotor decortication abolished drug-induced turning behaviour. It is postulated that subcortical basal ganglia efferent pathways may be involved in the mediation of motor asymmetry after unilateral 6-OHDA lesions of the nigrostriatal dopaminergic projection.
mesh_terms: D000661:Amphetamine; D000818:Animals; D001058:Apomorphine; D001479:Basal Ganglia / Q000503:physiopathology*; D001480:Basal Ganglia Diseases / Q000139:chemically induced / Q000503:physiopathology*; D001931:Brain Mapping; D002541:Cerebral Decortication; D005260:Female; D005917:Globus Pallidus / Q000503:physiopathology; D006892:Hydroxydopamines; D009044:Motor Cortex / Q000503:physiopathology*; D009434:Neural Pathways; D051381:Rats; D013787:Thalamic Nuclei / Q000503:physiopathology
chemical_list: D006892:Hydroxydopamines; D000661:Amphetamine; D001058:Apomorphine