Penta-acetyl-gitoxin: the prototype of a prodrug in the cardiac glycoside series.
Penta-acetyl-gitoxin is a suitable prodrug of gitoxin since it shows--side-effect latentiation, due to its inactive application form;--bioavailability, due to its improved solubility and thus good enteral absorption and--bioactivation, due to rapid de-acetylation in the body after absorption.
D000818:Animals; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D004071:Digitalis Glycosides / Q000378:metabolism* / Q000494:pharmacology; D004074:Digitoxin / Q000378:metabolism / Q000494:pharmacology; D006168:Guinea Pigs; D006801:Humans; D066298:In Vitro Techniques; D009129:Muscle Tonus / Q000187:drug effects; D051381:Rats
D004071:Digitalis Glycosides; D004074:Digitoxin