title: The effect of apomorphine injection into caudate nucleus on electrical activity of some structures of the rabbit brain.
abstract: The studies were carried out on rabbits with chronically implanted electrodes and cannulas. Apomorphine, dopamine, or haloperidol were injected into the caudate nucleus of wakeful rabbits at a volume of 2 microliter. EEG was recorded from gyrus cinguli anterior, nucleus dorsalis raphe, and dorsal part of hippocampal formation. Apomorhine produced a dose-dependent desynchronization of EEG in the structure tested. This effect did not appear when dopaminergic receptors were blocked by previous systemic (1.2 mg/kg) or intracaudal (10microgram) injection of heloperidol.
mesh_terms: D000818:Animals; D001058:Apomorphine / Q000008:administration & dosage / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects*; D002421:Caudate Nucleus; D003344:Cortical Synchronization; D004298:Dopamine / Q000494:pharmacology; D004569:Electroencephalography; D006220:Haloperidol / Q000494:pharmacology; D007267:Injections; D008032:Limbic System; D011817:Rabbits; D011903:Raphe Nuclei
chemical_list: D006220:Haloperidol; D001058:Apomorphine; D004298:Dopamine