title: Antileukemic activity of derivatives of 1-phenyl-2,5-dimethyl-3,4-bis(hydroxymethyl)pyrrole bis(N-methylcarbamate).
abstract: Treatment of N-aryl-N-acetylalanine derivatives, 3, with acetic anhydride-dimethyl acetylenedicarboxylate gave the dimethyl N-aryl-2,5-dimethylpyrrole-3,4-dicarboxylates, 4. Reduction of 4 and acylation of 5 gave 2a-j and 6. All of the title compounds 2a-j and 6 showed significant reproducible activity in the P388 in vivo antileukemic assay.
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D005260:Female; D007942:Leukemia, Experimental / Q000503:physiopathology*; D008297:Male; D051379:Mice; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D011758:Pyrroles