Effects of phosphate supplementation on intact and fractured femora of rats: a biomechanical study.
The production of a better and stronger healing bone has attracted the interest of many investigators in the past. Numerous substances have been used to increase both the strength and the rate of production of fracture callus. Recently phosphate, administered orally, has been suggested for this purpose. A biomechanical study was conducted with rat femora and variable doses of phosphate in this regard. Phosphate was found to benefit osteomalacic bones but to have no effect on normal bones and a toxic effect in high concentrations.
D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001696:Biomechanical Phenomena; D002146:Bony Callus / Q000187:drug effects; D002118:Calcium / Q000097:blood; D004195:Disease Models, Animal; D005264:Femoral Fractures / Q000503:physiopathology; D050723:Fractures, Bone / Q000503:physiopathology*; D008297:Male; D010710:Phosphates / Q000494:pharmacology*; D010758:Phosphorus / Q000097:blood; D051381:Rats; D014945:Wound Healing / Q000187:drug effects
D010710:Phosphates; D010758:Phosphorus; D000469:Alkaline Phosphatase; D002118:Calcium