Consequence of solubility alteration by salt effect on dissolution enhancement and biological response of a solid dispersion of an experimental antianginal drug.
Improvement of dissolution of a poorly water-soluble experimental antianginal drug has been obtained by solid dispersion preparation. Its solubility decreased with rising chloride ion concentration and biological responses in dogs varied with the gastrointestinal administration site. A correlation seemed to exist between the apparent solubility and the heart rate activity.
D000588:Amines / Q000494:pharmacology*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D001596:Benzylamines / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D001682:Biological Availability; D002712:Chlorides; D004285:Dogs; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D008297:Male; D011759:Pyrrolidines / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D012995:Solubility
D000588:Amines; D000889:Anti-Arrhythmia Agents; D001596:Benzylamines; D002712:Chlorides; D011759:Pyrrolidines