Experimental investigations of the renal tolerance of cefazedone.
Renal tolerance tests in Wistar rats (n = 40) over 12 days showed that the tubulotoxic threshold dose of the cephalosporin antibiotic (6R,7R)-7-(2-[3,5-dichloro-4-oxo-1(4H)-pyridyl]-acetamido)-3-([(5-methyl-1,3,4-thiadiazol-2-yl)-thio]methyl)-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylic acid acid (cefazedone, Refosporen) is 2000 mg/kg/day when the cell excretion rates in the urine are used as the parameter of toxicity. It is concluded that cefazedone and cefazolin are similar in respect of their nephrotoxicity.
D000818:Animals; D001219:Aspartate Aminotransferases / Q000652:urine; D002511:Cephalosporins / Q000633:toxicity*; D005260:Female; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D007674:Kidney Diseases / Q000139:chemically induced* / Q000201:enzymology / Q000473:pathology; D007684:Kidney Tubules / Q000166:cytology / Q000187:drug effects; D007770:L-Lactate Dehydrogenase / Q000652:urine; D008291:Malate Dehydrogenase / Q000652:urine; D051381:Rats; D014556:Urine / Q000166:cytology
D002511:Cephalosporins; D007770:L-Lactate Dehydrogenase; D008291:Malate Dehydrogenase; D001219:Aspartate Aminotransferases