3H-Cymarol in man. Excretion pathways and serum protein binding.
In 10 patients, 5 having received 3H-cymarol i.v., 5 orally, the radioactivity in plasma, urine and in the feces of some patients also was determined. After oral administration the plasma levels rose rapidly reaching maximum levels 1--2 h after administration. After i.v. injection about 30% of the given radioactivity were excreted in the urine. The remaining radioactivity was found in the feces suggesting a high biliary excretion. Only 10% of the radioactivity excreted in the first 24 h were chloroform-extractable. The radioactivity found in the urine after oral administration of the drug amounted to 17.6%. Between 51.1 and 58.5% of the drug were bound to serum proteins.
D000368:Aged; D001798:Blood Proteins / Q000378:metabolism; D003529:Cymarine / Q000031:analogs & derivatives / Q000097:blood / Q000378:metabolism* / Q000652:urine; D005243:Feces / Q000032:analysis; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D008875:Middle Aged; D011485:Protein Binding; D013328:Strophanthins / Q000378:metabolism*
D001798:Blood Proteins; D013328:Strophanthins; D003529:Cymarine