title: [Synthesis and virostatic activity of adamantan-1-carbonic acid amidines (author's transl)].
abstract: 33 different adamntyl amidines containing four different structural types were synthesized and checked for virostatic activity. The activity of compounds of type II seems to originate in their ability to form H-bonds. The strength of antiviral activity is at least partly determined by the electronic effects of substituents at the benzene ring.
mesh_terms: D000218:Adamantane / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis*; D001952:Bridged-Ring Compounds / Q000138:chemical synthesis*; D008722:Methods; D013329:Structure-Activity Relationship
chemical_list: D000998:Antiviral Agents; D001952:Bridged-Ring Compounds; D000218:Adamantane
vernacular_title: Uber Synthese und virustatische Wirkung von Adamantan-1-carbonsäureamidinen.