[Studies on the pharmacodynamic activity of several drug solvents. 2. Glycerin, N-(beta-hydroxyethyl)-lactamide, polyethylene glycol 400].
The drug solvents glycerin, N-(beta-hydroxyethyl)-lactamide, and polyethylene glycol 400 (Lutrol 9) were examined for their pharmacodynamic properties in the following tests: i.p. toxicity, "sign pattern", inclined screen test, balance rod test, and potentiation of hexobarbitone sleeping time in mice, spasmolytic activity in the guinea pig isolated ileum, and cardiovascular studies in anaesthetized rats, cats, and dogs including the i.v. toxicity. In mice and rats glycerin exhibited the highest tocicity as well as the greatest activity in potentiating hexobarbitone sleeping time. In the isolated ileum the solvents showed unspecific spasmolytic activities with histamine, carbachol, and BaCl2 as spasmogens. After i.v. administration in rats, cats, and dogs the solvents caused cardiovascular effects even in very low doses. Based on the pharmacodynamic properties, doses are recommended for each solvent which should not be exceeded without control experiments in the laboratory routine. These tolerable doses do not only depend on the species but also on the test concerned.
D000818:Animals; D002415:Cats; D004285:Dogs; D004347:Drug Interactions; D004983:Ethanolamines / Q000494:pharmacology* / Q000633:toxicity; D005260:Female; D005990:Glycerol / Q000494:pharmacology*; D006003:Glycogen / Q000633:toxicity; D006168:Guinea Pigs; D006439:Hemodynamics / Q000187:drug effects; D006591:Hexobarbital / Q000494:pharmacology; D006993:Hypnotics and Sedatives; D066298:In Vitro Techniques; D007773:Lactates / Q000494:pharmacology* / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D011092:Polyethylene Glycols / Q000494:pharmacology* / Q000633:toxicity; D004856:Postural Balance / Q000187:drug effects; D051381:Rats; D012997:Solvents / Q000494:pharmacology* / Q000633:toxicity
D004983:Ethanolamines; D006993:Hypnotics and Sedatives; D007773:Lactates; D012997:Solvents; D011092:Polyethylene Glycols; D006003:Glycogen; D006591:Hexobarbital; D005990:Glycerol
Ausgewählte Untersuchungen zur pharmakodynamischen Eigenwirkung verschiedener Lösungsvermittler. 2. Mitteilung: Glycerin, N-Hydroxythyllactamid, Polythylenglycol 400.