Urinary iodine excretion rates following intrathecal injections of iodinated organic carbonates.
Oily iodinated organic carbonates were investigated for use as myelographic media. The urinary excretion of total iodine was used to monitor the apparent elimination rate of these compounds from the subarachnoid space. Within the chain length series of C2-C6, the decrease of elimination rates and disposition rate constants with increasing chain length was demonstrated. This observation is consistent with a dissolution rate-limited elimination model. Such a model was derived and successfully NONLIN computer fitted to the observed elimination data. The model-derived parameter of clearance from the cerebrospinal fluid through the lipid "blood-brain barrier" correlated well with the compound's water solubilities and projected octanol-water partition coefficients. Additional compounds need to be tested to evaluate the postulated model system.
D000818:Animals; D002254:Carbonates / Q000008:administration & dosage / Q000378:metabolism*; D003287:Contrast Media / Q000008:administration & dosage / Q000378:metabolism*; D005260:Female; D007278:Injections, Spinal; D007455:Iodine / Q000652:urine*; D007700:Kinetics; D008954:Models, Biological; D051381:Rats; D012995:Solubility
D002254:Carbonates; D003287:Contrast Media; D007455:Iodine