title: The interactions of ticlopidine and aspirin in normal subjects.
abstract: This trial was performed on 24 health volunteers in order to study the possible interactions between aspirin and ticlopidine. The results confirm the inhibitory activity of aspirin on collagen-induced aggregation and that of ticlopidine on ADP-induced aggregation. If aspirin does not modify the inhibitory effect of ticlopidine on ADP-induced aggregation, ticlopidine on the other hand potentiates the effect of aspirin on collagen-induced aggregation.
mesh_terms: D000328:Adult; D001241:Aspirin / Q000494:pharmacology*; D004357:Drug Synergism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects*; D011725:Pyridines / Q000494:pharmacology*; D013876:Thiophenes / Q000494:pharmacology*
chemical_list: D011725:Pyridines; D013876:Thiophenes; D001241:Aspirin