Studies on some new thiosemicarbazones as potential antitubercular agents.
Twenty-one 4-aryl-3-thiosemicarbazides and their new vanillin-4-aryl-3-thiosemicarbazones have been prepared in good yield. Antitubercular activity of five of the vanillin-4-aryl-3-thiosemicarbazones was evaluated against mycobacterium tuberculosis strain H37 Ra in Löwenstein-Jensen medium. In addition to IR, biological activity and TLC studies for thiosemicarbazones were carried out.
D000995:Antitubercular Agents / Q000138:chemical synthesis*; D005421:Flavoring Agents / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013882:Thiosemicarbazones / Q000138:chemical synthesis* / Q000494:pharmacology
D000995:Antitubercular Agents; D005421:Flavoring Agents; D013882:Thiosemicarbazones