[The pre- and postoperative 2,3-diphosphoglycerate concentration of erythrocytes in children with cyanotic heart disease].
The behaviour of 2,3-diphosphoglycerate concentration (2,3-DPG) of red blood cells of babies and children with cyanotic heart diseases is studied before and after shunt operations. In babies with cyanotic heart diseases at the age of up to 6 months an increase of 2,3-DPG-level and haematocrit (HCT) is seen. Later, the compensation of chronic hypoxia is effected by further increase of HCT at unchanged high 2,3-DPG-level. The 2,3-DPG concentration which is still increased after successfull shunt operations as compared with the normal value is considered as an effective adaptation mechanism to the residual hypoxia presenting only a small load on the circulatory system. The 2,3-DPG concentration alone does not represent a criterion for the assessment of chronic hypoxia.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004163:Diphosphoglyceric Acids / Q000097:blood*; D004912:Erythrocytes / Q000378:metabolism*; D006330:Heart Defects, Congenital / Q000097:blood* / Q000601:surgery; D006400:Hematocrit; D006801:Humans; D000860:Hypoxia; D007223:Infant; D007231:Infant, Newborn; D010100:Oxygen / Q000097:blood
D004163:Diphosphoglyceric Acids; D010100:Oxygen
Verhalten des 2,3-Diphosphoglyzerats in roten Blutzellen bei Kindern mit zyanotischen Herzfehlern prä- und postoperativ.