title: [Thyroid tissue link of hemostasis in diffuse toxic and euthyroid goiter].
abstract: Blood coagulation system and fibrinolysis factors contained in the thyroid gland tissue of patients with diffuse toxic and euthyroid goiter and also of apparently healthy persons were investigated. The thyroid gland of healthy persons was shown to possess thromboplastin, antithrombin, anticoagulant, antiheparin, and fibrinolytic properties and to contain plasminogen, plasminogen activators, antiplasmins. The function of the external hemocoagulation system was reduced due to diminished thromboplastin and antiheparin activity of the gland tissue, reduction of aggregation and increase of disaggregation properties of the gland tissue. External blood coagulation system was undisturbed in patients with euthyroid gland. Local fibrinolysis was enhanced in patients with diffuse toxic goiter on account of increase in the thyroid gland of plasminogen activators, reduction of antiplasmin activity, and increase of the nonenzymatic fibrinolysis activity. Analogous changes in local fibrinolysis occurred in patients with euthyroid goiter.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects; D005343:Fibrinolytic Agents; D006042:Goiter / Q000097:blood*; D006111:Graves Disease / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects; D013961:Thyroid Gland; D014020:Tissue Extracts / Q000494:pharmacology*
chemical_list: D005343:Fibrinolytic Agents; D014020:Tissue Extracts
vernacular_title: Tkanevoe zveno gemostaza u bol'nykh diffuznym toksicheskim zobom.