title: [Experimental protection with tyrothrizin against herpes simplex virus infections in mice].
abstract: Using 12-day old baby mice, strain NMRI, the LD50 of a Herpes simplex virus type 1 was calculated. Intragastric inoculation of the mice was carried out applying a stomach tube. Lethality of the mice was reduced from 67% to 23% by pre-incubation of the virus suspension for 30 min at 37 degrees C in the presence of 0.2 mg tyrothricin/ml. The effect was statistically significant and could be produced only after direct contact between tyrothricin and virus. Under the same conditions there was no effect of lysozyme against virus infectivity.
mesh_terms: D000818:Animals; D004347:Drug Interactions; D006561:Herpes Simplex / Q000401:mortality / Q000517:prevention & control*; D051379:Mice; D009113:Muramidase / Q000627:therapeutic use; D013997:Time Factors; D014449:Tyrothricin / Q000627:therapeutic use*
chemical_list: D014449:Tyrothricin; D009113:Muramidase
vernacular_title: Schutzversuche mit Tyrothricin an der Herpes-simplex-Virus-infizierten Maus.