The synthesis of 13-cis-dl-erythro-15,16-dihydroxyprostaglandins.
Both pairs of dl-11-desoxy- and dl-13-cis-erythro-15,16-dihydroxyprostaglandins have been synthesized via 1,4-conjugate additions of an appropriately functionalized cis-vinyl cuprate to the requisite cyclopentenone. These prostaglandin analogs are considerably less potent than PGE2 as gastric secretion inhibitors or as bronchodilators.
D001980:Bronchi / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D005750:Gastric Juice / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects; D006801:Humans; D011453:Prostaglandins / Q000138:chemical synthesis*; D011465:Prostaglandins, Synthetic / Q000494:pharmacology
D011453:Prostaglandins; D011465:Prostaglandins, Synthetic