1,3-dicyclohexyl-5-alkyl-5-aminomethylbarbituric acids as potential antiinflammatory agents.
The synthesis and the structure of 1,3-dicyclohexyl-5-alkyl-5-aminomethylbarbituric acids, obtained by the Mannich reaction, are described. Some of the obtained compounds showed a strong antiinflammatory activity in biological tests.
D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis*; D001463:Barbiturates / Q000138:chemical synthesis*; D003460:Crystallization; D007202:Indicators and Reagents; D008352:Mannich Bases
D000893:Anti-Inflammatory Agents; D001463:Barbiturates; D007202:Indicators and Reagents; D008352:Mannich Bases