Metabolism of [3H]serotonin in the marine mollusc, Aplysia californica.
The fate of serotonin was studied in several tissues of the marine mollusc, Aplysia californica. When isolated nervous tissue was bathed in [3H]serotonin, two radioactive derivatives were formed; both appeared to be sugar conjugates: the first, possibly of glucuronic acid, and the second, of a more complex sugar moiety. When [3H]serotonin was injected directly into cell bodies of identified neurons, both serotonergic and non-serotonergic, only the conjugate which behaved as the glucuronide was formed. [3H]Serotonin was also converted only to this substance during incubation with isolated heart, kidney and hemolymph. Metabolic activity of the blood resided within cellular elements. No evidence of oxidative deamination was found in any tissue. In contrast to serotonin, however, [3H]tryptamine was readily oxidized to indoleacetic acid by nervous tissue.
D000107:Acetylation; D000818:Animals; D001048:Aplysia / Q000378:metabolism*; D002642:Chick Embryo; D005724:Ganglia / Q000378:metabolism; D006458:Hemolymph / Q000378:metabolism; D066298:In Vitro Techniques; D007668:Kidney / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism*; D014363:Tryptamines / Q000378:metabolism
D014363:Tryptamines; D012701:Serotonin