title: Comparison of the immune response in serum and bucco-pharyngeal secretions following immunization by different routes with a live hog cholera virus vaccine (Thiverval strain).
abstract: The influence of vaccination route on local and systemic immune response was studied with hog cholera virus vaccine. Kinetics of antibody synthesis in serum and bucco-pharyngeal secretion was observed. Results show that, whatever the vaccination route (intranasal or intramuscular) a good systemic and local immune response were induced and pigs resisted to a virulent challenge. However the highest local immune response was obtained by intranasal vaccination with large vaccine dosage (10(7) P.F.U./pig). After a virulent challenge performed by intranasal route, no clear anamnestic immune response was detected in bucco-pharyngeal secretions.
mesh_terms: D000281:Administration, Intranasal; D000818:Animals; D000917:Antibody Formation; D006691:Classical Swine Fever / Q000517:prevention & control*; D007114:Immunization / Q000662:veterinary*; D007273:Injections, Intramuscular; D009055:Mouth / Q000276:immunology* / Q000378:metabolism; D009093:Mucus / Q000276:immunology; D009500:Neutralization Tests; D010614:Pharynx / Q000276:immunology* / Q000378:metabolism; D012328:RNA Viruses / Q000276:immunology*; D013552:Swine / Q000276:immunology*; D014765:Viral Vaccines / Q000008:administration & dosage
chemical_list: D014765:Viral Vaccines