Effect of erythropoietin therapy on the red cell volume of uraemic and non-uraemic rats.
Studies were performed to determine the effect of injecting repeated doses of erythropoietin (Ep) on the red cell volume of chronically uraemic rats and on that of non-uraemic sham operated ones. After 13 doses of Ep (5 u/dose), started either 5 or 21 d after removal of five-sixths of the renal mass, the increase in the red cell volume of uraemic rats was as great as that of non-uraemic ones. The significance of these results is discussed.
D000740:Anemia / Q000188:drug therapy* / Q000209:etiology; D000818:Animals; D004911:Erythrocyte Volume; D004921:Erythropoietin / Q000627:therapeutic use*; D005260:Female; D006400:Hematocrit; D009392:Nephrectomy; D051381:Rats; D014511:Uremia / Q000150:complications / Q000188:drug therapy*
D004921:Erythropoietin