Influence of citalopram and chlorimipramine on uptake of 5-HT by isolated perfused guinea pig lungs.
A method is described for the preparation and perfusion in vitro of isolated guinea pig lungs, 5-HT is rapidly taken up from a perfusing solution by the organ (about 70% uptake). In the concentration range 10(-7) to 5 X 10(-6) M citalopram concentration dependently inhibited the uptake of 5-HT by the lung preparation. Chlorimipramine inhibited the uptake of 5-HT only by 40--50%, and the inhibition was not concentration dependent. The method used seems to be a reliable model for studying the uptake of 5-HT.
D000818:Animals; D001572:Benzofurans / Q000494:pharmacology*; D002997:Clomipramine / Q000494:pharmacology*; D003984:Dibenzazepines / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008168:Lung / Q000378:metabolism*; D008297:Male; D011437:Propylamines / Q000494:pharmacology*; D012701:Serotonin / Q000378:metabolism*; D012702:Serotonin Antagonists
D001572:Benzofurans; D003984:Dibenzazepines; D011437:Propylamines; D012702:Serotonin Antagonists; D012701:Serotonin; D002997:Clomipramine