title: [Toxicology of 1-4-dioxane].
abstract: Toxic parameters of 1-4 dioxan were estimated to be for white rats during 4 hr inhalation LC16 = 40 mg/l LC50 = 46 (42.2 +/- 50.1) mg/l; LC84 = 52 mg/l; for white mice during 2 hr inhalation LC16 = 61 mg/l; LC50 = 65 (61.3 +/- 68.2) mg/l; LC84 = 69.5 mg/l. As a result of single and repeated application, 1-4 dioxan did not induce skin changes, it was rapidly absorbed into the blood, and led to acute poisoning and irritation of the eye mucosa. A 24 hr exposure of white rats to 1-4 dioxan at concentrations of 4 and 20 mg/m3 for 90 days brought about their delayed weight gain, increased activity of glutamate-aspartate and glutamate-alanine transminases, prolonged duration of narcotic sleep, elevated content of protein in the urine, decreased diuresis, changed content of chlorides and altered motor chronaxia. The above concentrations proved to be effective. 1-4 dioxan at a concentrations proved to be effective. 1-4 dioxan at a concentration of 0.5 mg/m3 produced slight threshold changes.
mesh_terms: D000818:Animals; D003228:Conjunctiva / Q000187:drug effects; D004146:Dioxanes / Q000097:blood / Q000633:toxicity*; D004147:Dioxins / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004781:Environmental Exposure; D007928:Lethal Dose 50; D008099:Liver / Q000187:drug effects; D051379:Mice; D011817:Rabbits; D051381:Rats; D012869:Skin Absorption / Q000187:drug effects; D013997:Time Factors
chemical_list: D004146:Dioxanes; D004147:Dioxins
vernacular_title: Toksikologiia 1-4-dioksana.