[Antitumor action of new 2,4-diethyleneimino-6-amino-sym.-triazina derivatives].
In experiments of mice and rats with transplantable tumors (sarcoma 37, sarcoma 45, ascites Ehrlich tumor, etc) the authors studied the antitumor activity of a number of new water-soluble derivatives of 2,4-diethylenimino-6-amino-sym.-triazine differing only in the substituting radical associated with sym.-triazine cycle. All substances under study showed marked antitumor activity. The effect of the structure of the compounds concerned and their physico-chemical properties for antitumor activity are discussed.
D000818:Animals; D000970:Antineoplastic Agents; D001388:Aziridines / Q000627:therapeutic use / Q000633:toxicity*; D001389:Azirines / Q000633:toxicity*; D001773:Blood Cells / Q000187:drug effects; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D007928:Lethal Dose 50; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy; D051381:Rats; D012511:Sarcoma 37 / Q000188:drug therapy; D012513:Sarcoma, Experimental / Q000188:drug therapy; D013997:Time Factors; D014227:Triazines / Q000627:therapeutic use / Q000633:toxicity
D000970:Antineoplastic Agents; D001388:Aziridines; D001389:Azirines; D014227:Triazines
Protivoopukholevoe deĭstvie nekotorykh novykh proizvodnykh 2,4-diétilenimino-6-amino-simm.-triazina.