[Biotransformations of strophanthidin D- and L-arabinosides in the body of rats].
Metabolism of two cardiac glycosides--strophanthidine-3-alpha-L- and strophanthidine-3-alpha-D-arabinozide was studied at the stage of their passage via the liver and on the way of excretion by the kidneys in tests on albino rats by using paper chromatography. It was found that in passing through the liver both glycosides undergo a process of reduction of the aldehyde group at C1O to the alcoholic one. Different time periods of passage with urine were reduced, viz. strophanthidine-3-alpha-D-arabinozide and its metabolite are excreted during 24 hours and strophanthidine-3-alpha-L-arabinozide and the product of its transormation--within the space of 12 hours.
D000818:Animals; D001089:Arabinose / Q000378:metabolism; D001646:Bile / Q000032:analysis; D001711:Biotransformation; D006027:Glycosides / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D010084:Oxidation-Reduction; D051381:Rats; D013327:Strophanthidin / Q000031:analogs & derivatives* / Q000378:metabolism; D013997:Time Factors
D006027:Glycosides; D013327:Strophanthidin; D001089:Arabinose
Bioprevrashcheniia D- i L-arabinozidov strofantidina v organizme krys.