A teratological evaluation of anticonvulsant drugs.
Reviewing the important teratological data on anticonvulsants, the Hungarian experiences are reported. In the Hungarian Congenital Malformation Register use of the anticonvulsants diazepam and phenobarbiturates during pregnancy was determined in infants delivered with cleft lip with or without cleft palate, posterior cleft palate and, as a control, anencephaly and spina bifida. The teratogenic effect of diphenyl-hydantoin was confirmed, while that of diazepam and phenobarbital was not supported.
D000014:Abnormalities, Drug-Induced; D000757:Anencephaly / Q000139:chemically induced; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D002971:Cleft Lip / Q000139:chemically induced; D002972:Cleft Palate / Q000139:chemically induced; D003975:Diazepam / Q000009:adverse effects; D004827:Epilepsy / Q000188:drug therapy; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D010672:Phenytoin / Q000009:adverse effects; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy; D016136:Spina Bifida Occulta / Q000139:chemically induced
D000927:Anticonvulsants; D010672:Phenytoin; D003975:Diazepam