Zipeprol metabolism in man and in the animal.
The urinary metabolism of 1-(2-methoxy-2-phenyl)-ethyl-4-(2-hydroxy-3-methoxy-3-phenyl)-propyl-piperazine dihydrochloride (zipeprol) was studied in man, the dog and the rat. Zipeprol metabolites seemed comparable in man and rat. The principal metabolites isolated from urine were identified by TLC, GLC, IR and mass spectrometry. Zipeprol is partially eliminated untransformed from the body, is mainly metabolised by N-dealkylation, oxidation, hydroxylation and methylation.
D000284:Administration, Oral; D000818:Animals; D000996:Antitussive Agents / Q000378:metabolism* / Q000652:urine; D001711:Biotransformation; D004285:Dogs; D006801:Humans; D010879:Piperazines / Q000378:metabolism* / Q000652:urine; D051381:Rats; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D000996:Antitussive Agents; D010879:Piperazines