[Immunodepressive effect of mercazolyl].
Blood serum immunoglobulins and the process of peripheral blood blast-transformation of lymphocytes were studied in rats given mercazolyl in a dose of 0.9 mg/100 g of body weight orally for 80 days. This drug proved to produce an immunodepressive effect, which was more evidenced by the electrophoresis indices, and less (chiefly at the late periods of the experiment)--by the peripheral blood lymphocyte blasttransformation indices. The immunodepressive influence of mercazolyl on the animal organism should be taken into consideration in using this preparation in the capacity of a thyrostatic.
D000818:Animals; D007122:Immunoelectrophoresis; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007166:Immunosuppressive Agents; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D008713:Methimazole / Q000276:immunology*; D051381:Rats; D012621:Seasons; D013965:Thyroidectomy; D013997:Time Factors
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007166:Immunosuppressive Agents; D008713:Methimazole
Ob immunodepressivnom vliianii merkazolila.