1,25-dihydroxycholecalciferol in hypophosphataemic osteomalacia presenting in adults.
The effects of exogenous 1,25-dihydroxycholecalciferol (1,25(OH)2D3) in two adults with late-onset hypophosphataemic osteomalacia were studied. In the presence of elevated 25-hydroxyvitamin D levels 1,25OH)2D3 improved intestinal 47Ca absorption and increased urinary calcium, phosphate and hydroxyproline excretion. Hypophosphataemia, parathyroid hormone and bone mineralization were not significantly affected. The rise of the 1,25-dihyroxyvitamin D concentrations was dose dependent. The results indicate htat the impared renal phosphate conservation--the primary defect in this disorder--is not corrected by exogneous 1,25-dihydroxycholecalciferol.
D000328:Adult; D001842:Bone and Bones / Q000378:metabolism; D004100:Dihydroxycholecalciferols / Q000097:blood / Q000627:therapeutic use*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D006887:Hydroxycholecalciferols / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D008903:Minerals / Q000378:metabolism; D010018:Osteomalacia / Q000097:blood / Q000188:drug therapy*; D010760:Phosphorus Metabolism Disorders / Q000150:complications*
D004100:Dihydroxycholecalciferols; D006887:Hydroxycholecalciferols; D008903:Minerals