[Effect of organic acids on the biosynthesis of macrotetralide antibiotics by an Actinomyces chrysomallus var. carotenoides strain].
The biosynthesis of macrotetrolides by Actinomyces chrysomalus var. carotenoides was stimulated by acetic, succinic, propionic, oxalic, malic, tartaric, citric, pyruvic, alpha-ketoglutaric and fumaric acids. Incorporation of 14C-acetate into the molecule of the antibiotic and the data on dependence of the stimulating effect upon the quantitative ratio and time of the organic acid addition were indicative of the role of acetic, succinic and propionic acids as precursors of macrotetrolides. The other organic acids increased the biosynthesis of macrotetolides when added to the culture within wide time ranges of the culture development and prolonged the period of the mycelium productive state.
D000143:Acids / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D003470:Culture Media; D013302:Streptomyces / Q000187:drug effects* / Q000378:metabolism; D013997:Time Factors
D000143:Acids; D000900:Anti-Bacterial Agents; D003470:Culture Media
Vliianie organicheskikh kislot na biosintez makrotetralidnykh antibiotikov shtammom Actinomyces chrysomallus var. carotenoides.