[Antitumor properties and toxicity of a carminomycin and protein complex].
The properties of carminomycin complexes with protein, a bovine serum albumin prepared with two different methods using glutaraldehyde or carbodiimine were studied. The complex prepared with the use of carbodiimine was biologically inactive. The complex prepared with the use of glutaraldehyde had a molecular mass of about 15 000 000 dalton, was more toxic than carminomycin and possessed proportionally higher antitumor activity and a wider antitumor spectrum. The studies on the use of the method of carminomycin complex formation with antitumor immunoglobulins are promising.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D002360:Carubicin / Q000627:therapeutic use* / Q000633:toxicity; D002417:Cattle; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D007928:Lethal Dose 50; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy; D046911:Macromolecular Substances; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy; D012710:Serum Albumin, Bovine / Q000627:therapeutic use* / Q000633:toxicity; D013329:Structure-Activity Relationship
D000903:Antibiotics, Antineoplastic; D004338:Drug Combinations; D046911:Macromolecular Substances; D012710:Serum Albumin, Bovine; D002360:Carubicin
Protivoopukholevye svoĭstva i toksichnost' kompleksa karminomitsina s belkom.