Effect of cations on tetraehtylammonium exit from mouse kidney cortex slices.
Exit of 14C-tetraethylammonium (TEA) was studied in mouse kidney cortex slices incubated in Krebs-Ringer bicarbonate buffer (37 degrees C, pH 7.4) aerated with O2-CO295:5 v/v%. Substitution of Na+ in the wash out buffer by K+, Rb+ or the organic cations TEA and choline resulted in a stimulation of exit which, however, may be secondary to concomitant biochemical changes in the tissue (increase of water content and relative loss of K+) seen in the presence of these cations. However, enhancement of 14C-TEA exit although less pronounced was also produced of low organic cation concentrations having no effect on tissue water and K+. The latter specific effect on 14C-TEA exit may represent an interaction phenomenon in renal organic cation transport of accelerative exchange diffusion type.
D000818:Animals; D002412:Cations / Q000494:pharmacology*; D066298:In Vitro Techniques; D007672:Kidney Cortex / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051379:Mice; D011188:Potassium / Q000378:metabolism; D013268:Stimulation, Chemical; D013757:Tetraethylammonium Compounds / Q000378:metabolism*; D014867:Water / Q000378:metabolism
D002412:Cations; D013757:Tetraethylammonium Compounds; D014867:Water; D011188:Potassium