[Influence of high intravenous doses of D-penicillamine on toxic actions of cardiac glycosides in the guinea pig. Short communication (author's transl)].
Intravenous infusions of arrhythmogenic and lethal doses of ouabain and digoxin in anesthetized guinea pigs were not influenced by pretreatment with 1 g/kg D-penicillamine. The respective doses of proscillaridin and digitoxin, however, were significantly decreased by D-penicillamine. As could be demonstrated with proscillaridin this effect of D-penicillamine was dose-dependent between 0.25 and 1.0 g/kg. Obviously the strong plasma-protein binding of D-penicillamine leads to a displacement from binding sites of such cardiac glycosides which are also strongly bound to plasma proteins and thus reduces toxic doses of cardiac glycosides. Because of the extremely different doses of D-penicillamine in the animal experiments compared to those used therapeutically in man the present findings are irrelevant for clinical practice.
D000818:Animals; D001667:Binding, Competitive / Q000187:drug effects; D001798:Blood Proteins / Q000378:metabolism; D002018:Bufanolides / Q000633:toxicity*; D004077:Digoxin / Q000633:toxicity*; D004562:Electrocardiography; D006168:Guinea Pigs; D007275:Injections, Intravenous; D010042:Ouabain / Q000633:toxicity*; D010396:Penicillamine / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D011442:Proscillaridin / Q000633:toxicity*; D011485:Protein Binding
D001798:Blood Proteins; D002018:Bufanolides; D010042:Ouabain; D004077:Digoxin; D010396:Penicillamine; D011442:Proscillaridin
Einfluss hoher i.v. Dosen von D-Penicillamin auf toxische Herzglykosidwirkungen am Meerschweinchen. Kurze Mitteilung.