[Studies on the recording of cytostatic effects on organ cultures of squamous cell carcinoma of the uterine cervix].
Organ cultures are a suitable in vitro test--object for pretherapeutical testing of cytostatic resistance on carcinomas of the cervix uteri. The decrease of activity of lactic dehydrogenase and isocitric acid dehydrogenase, determined histochemically, can be used to monitor cytostatic effects at the cultivated tumour. In preparing chemotherapy schedules for advanced cervical carcinomas, cytostatic agents provedly ineffective in vitro should be avoided.
D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000201:enzymology; D005260:Female; D006801:Humans; D007521:Isocitrate Dehydrogenase / Q000097:blood; D007770:L-Lactate Dehydrogenase / Q000097:blood; D009924:Organ Culture Techniques; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000201:enzymology
D000970:Antineoplastic Agents; D007770:L-Lactate Dehydrogenase; D007521:Isocitrate Dehydrogenase
Untersuchungen zur Erfassung zytostatischer Effekte an Organkulturen von Plattenepithelkarzinomen der Cervix uteri.