Synthesis and biological evaluation of 2 - and 4- hydroxymestranol.
The synthesis of 2-hydroxy and 4-hydroxymestranol by oxidation of mestranol with m-chloroperbenzoic acid is described. The oral estrogenicity and contragestational activity of these and related catechol estrogen derivatives in the rat is also presented.
D000818:Animals; D001681:Biological Assay; D005260:Female; D008656:Mestranol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D008722:Methods; D051381:Rats; D013329:Structure-Activity Relationship; D014599:Uterus / Q000187:drug effects
C015939:4-hydroxymestranol; D008656:Mestranol