The influence of D-penicillamine on cell proliferation. II. Quantitative investigations during a chronic proliferative inflammation in a model granuloma.
The influence of D-penicillamine (DPA) on a defined chronic proliferative inflammation in a model granuloma was tested in a long-term experiment. A change in collagen metabolism was detected during the three weeks of DPA administration, whereas the proliferation of the fibroblast population remained unaffected.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects*; D003094:Collagen / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D006099:Granuloma / Q000473:pathology; D007249:Inflammation / Q000473:pathology*; D008297:Male; D010396:Penicillamine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D003094:Collagen; D004247:DNA; D010396:Penicillamine