Hypotensive action of an intra-nasally applied angiotensin II-antagonist.
Intranasal administration of the specific angiotensin II-antagonist (1-NSuc-5-Val-8-Phg) A II was investigated in anaesthetized rats with different forms of experimentally elevated blood pressure. Renin- or angiotensin II-induced blood pressure increases were markedly reversed by the angiotensin II-antagonist applied intra-nasally. In rats with acute accelerated elevation of blood pressure the analogue induced also a significant decrease. No change could be observed in rats with chronic renal hypertension.
D000281:Administration, Intranasal; D000804:Angiotensin II / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D006977:Hypertension, Renal / Q000503:physiopathology; D008297:Male; D051381:Rats; D012083:Renin / Q000494:pharmacology
D000804:Angiotensin II; D012083:Renin