title: [Contribution to the pharmacology of a novel neuroleptic drug: flupenthixol (author's transl)].
abstract: Flupenthixol, which is chemically closely related to clopenthixol and fluphenamine, has the following properties: it reduces spontaneous motor activity, disturbs the behaviour, potentiates hexobarbital and chloral sleep, lowers central temperature and protects from death due to amphetamine; it is cataleptigenous and antagonizes apomorphic vomiting; it has marked adrenolytic and antihistaminic properties; its analgesic action is noteworthy. Flupenthixol presents the pharmacological profile of a neuroleptic drug.
mesh_terms: D000588:Amines / Q000378:metabolism; D000661:Amphetamine / Q000494:pharmacology; D000700:Analgesics; D000818:Animals; D000932:Antiemetics / Q000494:pharmacology; D001831:Body Temperature / Q000187:drug effects; D002697:Chloral Hydrate / Q000494:pharmacology; D005475:Flupenthixol / Q000494:pharmacology* / Q000633:toxicity; D006168:Guinea Pigs; D006439:Hemodynamics / Q000187:drug effects; D006591:Hexobarbital / Q000494:pharmacology; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D012890:Sleep / Q000187:drug effects; D013892:Thioxanthenes / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D000588:Amines; D000700:Analgesics; D000932:Antiemetics; D013892:Thioxanthenes; D002697:Chloral Hydrate; D006591:Hexobarbital; D000661:Amphetamine; D005475:Flupenthixol
vernacular_title: Beitrag zur Pharmakologie eines Neuroleptikums: Flupenthixol.