title: Absorption of amino acids from the small bowel and their activity in releasing of cholecystokinin.
abstract: The ability of essential and nonessential amino acids to stimulate the release of CCK was investigated in dogs using a bioassay procedure based on the perfusion of intestinal Thiry-Vella loops and determing the increase of pancreatic protein response as well as the potentiation of pancreatin bicarbonate secretion by a background doses of secretin (0.2 units/kg/h). All essential amino acids, except threonine, and all nonessential amino acids except cysteine were effective in CCK release when perfused in equimolar concentration (50-mM) through the intestinal loop. The peak pancreatic protein in response to tryptophan was about 89% of the maximal response to exogenous CCK in a dose of 25 units/kg/h. These data have also indicated that tryptophan and phenyloalanine are able to release small amounts of secretin.
mesh_terms: D000596:Amino Acids / Q000378:metabolism* / Q000502:physiology*; D000601:Amino Acids, Essential / Q000378:metabolism / Q000502:physiology; D000818:Animals; D001639:Bicarbonates / Q000378:metabolism; D002766:Cholecystokinin / Q000378:metabolism* / Q000494:pharmacology; D004285:Dogs; D007413:Intestinal Mucosa / Q000378:metabolism*; D007421:Intestine, Small / Q000378:metabolism*; D010179:Pancreas / Q000378:metabolism; D011506:Proteins / Q000378:metabolism
chemical_list: D000596:Amino Acids; D000601:Amino Acids, Essential; D001639:Bicarbonates; D011506:Proteins; D002766:Cholecystokinin