Serum complement changes in W/Fu rats inoculated with syngeneic (C58NT) D lymphoma cells.
Weanling W/Fu rats were inoculated intraperitoneally with 1 X 10(6) to 1 X 10(7) (C58NT)D Gross virus-induced lymphoma cells. Sera obtained 7 days later showed moderate to marked depressions of overall hemolytic activity, C1, C3 and properdin. These changes were not observed in uninjected W/Fu rats or in animals inoculated with syngeneic normal spleen cells. In the latter group and in the tumor-bearing animals, factor B levels were also depressed. Evidence of complement utilization was also observed in the ascitic fluids of the tumor-bearing W/Fu rats.
D000406:AKR murine leukemia virus / Q000276:immunology; D000818:Animals; D003172:Complement C1 / Q000096:biosynthesis; D003176:Complement C3 / Q000096:biosynthesis; D011415:Complement Factor B / Q000096:biosynthesis; D003165:Complement System Proteins; D006461:Hemolysis; D007942:Leukemia, Experimental / Q000276:immunology*; D011414:Properdin / Q000096:biosynthesis; D011817:Rabbits; D051381:Rats; D011920:Rats, Inbred WF
D003172:Complement C1; D003176:Complement C3; D011414:Properdin; D003165:Complement System Proteins; D011415:Complement Factor B