[Methods for simultaneous recording of pharmacodynamic and toxic effects on interior sensitive receptors, respiration and cardiac-circulatory system of guinea pigs (author's transl)].
A method for simultaneous, continuous registration of pharmacodynamic and toxic effects, resp., on pulmonary-stretch receptors, on respiration and on hemodynamics in guinea pigs is described. The following parameters are recorded synchronously by a multi-track recorder: 1. The afferences in the cervical n. vagus; its electrical integration is employed for measuring the total intensity and the ex- and the inhalation intensity, resp., of the afferences; 2. the pneumatogram for measuring the maximum velocity of air flow, duration of the breath phase and parts thereof (in-, and exhalation and postexpiratory pause), and the respiration rate; 3. the diastolic and systolic blood pressure during in- and exhalation and postexpiratory pause; 4. the electrocardiogram (ECG). The normal distribution of the initial values is examined and discussed. Further the initial values measured in three series of experiments are discussed and compared: mono-vagotomy/spontaneous respiration, bivagotomy/spontaneous respiration and artificial respiration/monovagotomy. The results are compared with some experimental and clinical findings from literature.
D000818:Animals; D001794:Blood Pressure; D006168:Guinea Pigs; D006339:Heart Rate; D006439:Hemodynamics; D008465:Mechanoreceptors / Q000502:physiology*; D008722:Methods; D010600:Pharmacology / Q000379:methods*; D012119:Respiration; D014116:Toxicology / Q000379:methods*; D014628:Vagotomy; D014630:Vagus Nerve / Q000502:physiology
Methode zur simultanen Registrierung von pharmakodynamischen bzw. toxischen Effekten auf innere sensible Rezepforen, auf die Atmung und auf das Herz-Kreislauf-System von Meerschweinchen.