Attempted induction of granulosa cell tumor in Balb-C mice by gonadotropin administration.
An attempt of granulosa cell tumor (GCT) induction by prolonged administration of exogenous pregnant mare's serum gonadotropin (PMSG) to young, mature, and middle-aged Balb-C mice resulted mainly in stromal luteal cell proliferation. 48.9% of young mice, 64.5% of mature mice and 65% of middle-aged mice developed luteal cell proliferation. This effect seemed to be dependent on duration of treatment, mainly in young mice. Young mice injected for less than 6 months developed significantly less luteal cell proliferation than those injected for more than 6 months. Only 1 GCT was found. This study seems to support the contention that besides gonadotropin stimulation, other factors may be involved in GCT development. A large number of PMSG-injected mice developed generalized lymphosarcoma, the mechanism of which remains unknown.
D000367:Age Factors; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D005260:Female; D006064:Gonadotropins, Equine / Q000008:administration & dosage; D006106:Granulosa Cell Tumor / Q000139:chemically induced*; D008228:Lymphoma, Non-Hodgkin / Q000139:chemically induced; D051379:Mice; D008807:Mice, Inbred BALB C; D009374:Neoplasms, Experimental / Q000139:chemically induced; D010051:Ovarian Neoplasms / Q000139:chemically induced*; D010053:Ovary / Q000473:pathology; D013997:Time Factors
D006064:Gonadotropins, Equine