Effect of dieldrin on the stability of lysosomes in the rat liver.
The effect of dieldrin on the bound and free activity of cathepsin, acid ribonuclease, acid phosphatase and aryl sulphatase has been investigated. Administration of dieldrin increased the activity of free cathepsin, acid ribonuclease, and acid phosphatase in rat liver whereas it did not affect the activity of aryl sulphatase. This indicates that dieldrin labilizes the lysosomes.
D000135:Acid Phosphatase / Q000032:analysis; D000818:Animals; D001192:Arylsulfatases / Q000032:analysis; D002403:Cathepsins / Q000032:analysis; D004026:Dieldrin / Q000494:pharmacology*; D066298:In Vitro Techniques; D008099:Liver / Q000648:ultrastructure*; D008247:Lysosomes / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D051381:Rats; D012260:Ribonucleases / Q000032:analysis
D012260:Ribonucleases; D000135:Acid Phosphatase; D001192:Arylsulfatases; D002403:Cathepsins; D004026:Dieldrin