title: Synthesis and hypoglycemic activity of 4-substituted 3-mercaptopicolinic acids.
abstract: 3-Mercapto-4-methylpicolinic acid one of very few compounds derived from 3-mercaptopicolinic acid (3-MPA) to have hypoglycemic activity. In an effort to find compounds with greater potency than 3-MPA, several 4-substituted 3-mercaptopicolinic acids (4-OMe, OC6H5, SMe, SH, Cl, NH2, Et; 1-7) were prepared and tested in 48-h fasted rats. None was hypoglycemic in this test system after oral dosing of 150 mg/kg.
mesh_terms: D000818:Animals; D007004:Hypoglycemic Agents / Q000138:chemical synthesis*; D008297:Male; D010848:Picolinic Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D007004:Hypoglycemic Agents; D010848:Picolinic Acids; D013438:Sulfhydryl Compounds