Swine cell systems as interferon producers. IV. Comparative studies on the correlation between virulence of different Newcastle disease virus strains and their potency as interferon inducers.
Comparative studies concerning a correlation between virulence of various Newcastle virus strains and their interferon-inducing potency confirmed that such a correlation existed. The nearly avirulent La Sota strain of NDV was the poorest interferon inducer, the virulent Hertfordshire strain manifested a very good inducing potency. However, the most virulent J.B. strain virus was a poorer interferon inducer than the Hertfordshire strain. This should not be viewed as contradictory to the conclusion of the correlation between virulence and interferon-inducing ability of NDV since the highly virulent strain might destroy faster the interferon-producing cells, before the latter produced the maximum interferon quantity which they potentially could produce.
D000818:Animals; D046508:Culture Techniques; D007369:Interferon Inducers; D007372:Interferons / Q000096:biosynthesis*; D007668:Kidney; D007962:Leukocytes / Q000378:metabolism; D008168:Lung; D009522:Newcastle disease virus; D013552:Swine; D014774:Virulence
D007369:Interferon Inducers; D007372:Interferons