title: [Reactivation of phosphorylated acetylcholinesterase. Isomeric bisquaternary salts of pyridine aldoximes].
abstract: Mono-quaternary salts Z have been prepared from pyridine-aldoximes and 1,3-dihalogen compounds. These were used to synthesize asymmetrical bis-quaternary pyridine-oximes with three-membered bridge. The effect of reactivation of phosphorylated AChE by these substances is less than that of obidoxim (Toxogonin).
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism*; D055598:Chemical Phenomena; D002621:Chemistry; D004793:Enzyme Reactivators / Q000138:chemical synthesis*; D007536:Isomerism; D011220:Pralidoxime Compounds / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D004793:Enzyme Reactivators; D011220:Pralidoxime Compounds; D000110:Acetylcholinesterase
vernacular_title: Reaktivierung phosphorylierter Acetylcholin-Esterase. Isomere bisquartäre Salze von Pyridin-aldoximen.