[Therapeutic measures in osteogenesis imperfecta (author's transl)].
The treatment of osteogenesis imperfecta with magnesium is theoreticaly sound, but usually works in a few individuals. There are greater expectations with calcitonin, which reduces the overall osteolysis. The treatment of fractures should, whenever possible, be concervative. Internal fixation by plates is not indicated, because the plate should span from metaphysis to metyphysis, which leads to a softeming of the underlying cortex. Because of the weak bone, srews do not hold well. For operative treatment of the lower limb, the Küntscher nail is the fixation of choice, as well as for treatment of deformity by multiple fragmentation. Rapidly progressive scoliosis should be treated operatively from 9 years of age on.
D000367:Age Factors; D001205:Ascorbic Acid / Q000627:therapeutic use; D001858:Bone Nails; D002116:Calcitonin / Q000627:therapeutic use; D002648:Child; D005592:Fracture Fixation; D005594:Fracture Fixation, Intramedullary; D005598:Fractures, Spontaneous / Q000209:etiology / Q000601:surgery; D006801:Humans; D007223:Infant; D008274:Magnesium / Q000627:therapeutic use; D010013:Osteogenesis Imperfecta / Q000150:complications / Q000188:drug therapy; D010014:Osteolysis / Q000517:prevention & control; D012600:Scoliosis / Q000209:etiology / Q000601:surgery
D002116:Calcitonin; D008274:Magnesium; D001205:Ascorbic Acid
Therapeutische Massnahmen bei der Osteogenesis imperfecta.