title: The effects of inhibition of fatty acid oxidation in suckling newborn rats.
abstract: Inhibition of fatty acid oxidation with pent-4-enoate in suckling newborn rats caused a fall in blood [glucose] and blood [ketone bodies] and inhibition of gluconeogenesis from lactate. Glucose utilization was not increased in newborn rats injected with pent-4-enoate. Active fatty acid oxidation appears to be essential to support gluconeogenesis and to maintain normal blood [glucose] in suckling newborn rats.
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism*; D005229:Fatty Acids, Monounsaturated; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D005943:Gluconeogenesis / Q000187:drug effects; D005951:Glucose Tolerance Test; D010084:Oxidation-Reduction; D051381:Rats; D012965:Sodium Chloride / Q000494:pharmacology; D014631:Valerates / Q000494:pharmacology
chemical_list: D005227:Fatty Acids; D005229:Fatty Acids, Monounsaturated; D005231:Fatty Acids, Unsaturated; D014631:Valerates; D012965:Sodium Chloride; C009785:4-pentenoic acid