title: [Analytical data and preparation of important 3-hydroxy-5-phenyl-1,4-benzodiazepin-2-one derivatives (author's transl)].
abstract: The article describes analytical data (TLC, IR, MS) of 7-chloro-1-methyl-1,3-hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-one (3-hydroxydiazepam) and 7-cyclopropyl-methyl-1,3-dihydro-3-hydroxy-5-phenyl-2H-1,4-benzodiazpin-2-one (3-hydroxy-prazepam). Analytical properties of important derivatives (N-oxides, 3-acetoxy compounds, re-arrangement products) are also reported. Besides preparation methods are given for the synthesis of these substances, considering in particular preparation as solution-reactions as well as reaction on the TLC-plate.
mesh_terms: D001570:Benzodiazepinones / Q000032:analysis* / Q000138:chemical synthesis; D001711:Biotransformation; D003975:Diazepam / Q000378:metabolism; D006868:Hydrolysis; D010084:Oxidation-Reduction; D011222:Prazepam / Q000378:metabolism
chemical_list: D001570:Benzodiazepinones; D011222:Prazepam; D003975:Diazepam
vernacular_title: Analytik und Synthese wichtiger 3-Hydroxy-5-phenyl-1,4-benzodiazepin-2-on-Derivate.