Morphological and biochemical changes in the gastric mucosa of A/HEJ mice injected with a xenogeneic stomach antigen.
Subcutaneous injection of W/Fu rat stomach antigen emulsified with an equal volume of Freund's complete adjuvant at 1 week interval for a total of 2 administrations induced atrophic gastritis in A/HeJ mice. From the second week after the last injection the parietal cell mass decreased. At the same time, Alcian blue-PAS positive cells and Paneth-like cells appeared. Furthermore, the activity of alkaline phosphatase and disaccharidase of the small intestinal mucosa was biochemically demonstrated in the atrophic glandular stomach.
D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D000941:Antigens / Q000008:administration & dosage*; D001284:Atrophy; D004186:Disaccharidases / Q000378:metabolism; D005753:Gastric Mucosa / Q000201:enzymology / Q000473:pathology*; D005756:Gastritis / Q000276:immunology* / Q000473:pathology; D008679:Metaplasia; D051379:Mice; D011708:Pylorus / Q000473:pathology; D051381:Rats; D013270:Stomach / Q000276:immunology*
D000941:Antigens; D000469:Alkaline Phosphatase; D004186:Disaccharidases