title: [Study of changes in certain immunoglobulin fractions in acute and chronic hepatopathies treated with alpha-mercaptopropionylglycine].
abstract: 15 patients have been treated with alpha-MPG (Thiola) by the intramuscular route and by venous infusion at doses varying from 500 mg to 1000 mg i.v. and from 100 mg to 200 mg i.m. for a treatment period of from 20 to 40 days. In a number of cases parenteral therapy was followed by oral therapy depending on the degree of liver insufficiency and the therapeutic response of the drug. In all cases, the drug proved to possess antitoxic and liver protector effectiveness and was without side effects gastroenterically and generally, even when administered at high doses for long periods. The results obtained are summarised in tables and data regarding patients at admission and discharge noted.
mesh_terms: D000208:Acute Disease; D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000603:Amino Acids, Sulfur / Q000627:therapeutic use*; D002908:Chronic Disease; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007273:Injections, Intramuscular; D008107:Liver Diseases / Q000188:drug therapy* / Q000276:immunology; D008875:Middle Aged; D008625:Tiopronin / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000603:Amino Acids, Sulfur; D007136:Immunoglobulins; D008625:Tiopronin
vernacular_title: Studio delle variazioni di particolari frazioni immunoglobuliniche nelle epatopatie acute e chroniche sottoposte a trattamento con alpha-mercaptopropionilglicina.