[Analgesic activity of probon compared to morphine].
The analgetic action of probone as compared to that of morphine was studied in chronic tests on cats. Changes in individual signs of a complex reaction in response to a graded stimulation of the cutaneous nerve were assessed. Probone in doses of 50--150 mg/kg and morphine in doses of 2--4 mg/kg raised the threshold of the flexor reflex and reduced manifestations of the emotional-behavioral and vegeto-motor reactions of the animals. But unlike morphine probone did not suppress the vocal reaction, this being a specific component of the response to pain. It is assumed that the change in the response reaction occurring under the effect of probone is due not so much to its analgetic action, but rather to the myorelax and tranquilizing effects.
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D002415:Cats; D004305:Dose-Response Relationship, Drug; D009020:Morphine / Q000494:pharmacology*; D011744:Pyrimidinones / Q000494:pharmacology*
D000700:Analgesics; D011744:Pyrimidinones; D009020:Morphine
Anal'geticheskaia aktivnost' probona v sravnenii s morfinom.