Synthesis and pharmacological testing on some theophylline esters.
Esters of theophylline-7-acetic acid with different amino alcohols were prepared as possible atropine substitutes, together with esters of some hydroxy acids with beta-hydroxyethyl theophylline. Moreover, esters possessing both theophyllinyl and piperazinyl moieties were prepared with the hope that their spasmolytic activity might be increased. Some of the prepared compounds proved to possess atropine-like activity.
D000109:Acetylcholine / Q000037:antagonists & inhibitors; D000818:Animals; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008722:Methods; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D013806:Theophylline / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
D013806:Theophylline; D000109:Acetylcholine