title: The effect of various doses of oral oestradiolvalerate and oestriolsuccinate on urine calcium/creatinine, serum FSH and endometrium in castrated women.
abstract: The effects of various doses recommended for clinical use of oestradiolvalerate and oestriolsuccinate on urine calcium/creatinine, serum FSH and endometrium were investigated in two castrated women. Oestrogen treatments were given in 6-week periods separated by 2 weeks without treatment. After various oestrogen treatments, serum FSH generally decreased clearly and urine calcium/creatinine slightly. The proliferative effect on endometrium was investigated histologically. In no period was a hyperplastic endometrium found.
mesh_terms: D000328:Adult; D002118:Calcium / Q000652:urine*; D002369:Castration; D002455:Cell Division / Q000187:drug effects; D003404:Creatinine / Q000652:urine*; D004717:Endometrium / Q000166:cytology / Q000187:drug effects*; D004958:Estradiol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D004964:Estriol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006801:Humans
chemical_list: D004958:Estradiol; D005640:Follicle Stimulating Hormone; D003404:Creatinine; D004964:Estriol; D002118:Calcium