title: Carcinogenic effect of a quanidine pesticide administered with sodium nitrite on adult mice and on the offspring after prenatal exposure.
abstract: Adult Swiss mice were treated intragastrically during the last week of pregnancy with the fungicide dodecylquanidine acetate (dodine, DGA) together with 0.05% sodium nitrite. The incidence of malignant lymphomas, lung adenomas and hepatomas was 30--70% in females. The first tumors appeared 4 months after delivery in the FO generation and at 6--7 months in the F1 generation. Among the untreated control mice the frequency of spontaneous tumors was 6%, and lymphomas developed, if at all, only after 10 months. The oncogenic activity of DGA with sodium nitrite in the offspring was dependent on the dose of DGA.A and C type RNA virus particles were demonstrated in lymphomas by electronmicroscopy. DGA alone had no effect on the cancer incidence.
mesh_terms: D000818:Animals; D002273:Carcinogens; D004357:Drug Synergism; D005260:Female; D005659:Fungicides, Industrial / Q000008:administration & dosage / Q000633:toxicity*; D006146:Guanidines / Q000008:administration & dosage / Q000633:toxicity*; D007181:Inclusion Bodies, Viral; D008228:Lymphoma, Non-Hodgkin / Q000139:chemically induced; D008297:Male; D008431:Maternal-Fetal Exchange; D051379:Mice; D009573:Nitrites / Q000633:toxicity*; D011247:Pregnancy; D012513:Sarcoma, Experimental / Q000139:chemically induced* / Q000648:ultrastructure; D012737:Sex Factors; D012977:Sodium Nitrite / Q000008:administration & dosage / Q000633:toxicity*
chemical_list: D002273:Carcinogens; D005659:Fungicides, Industrial; D006146:Guanidines; D009573:Nitrites; C006921:dodine; D012977:Sodium Nitrite