Carcinomas of the liver in Osborne-Mendel rats ingesting DDT.
Osborne-Mendel male and female rats ingested 200, 400, 600, or 800 ppm DDT composed of 81.8% p,p isomer and 18.2% o,p isomer for periods up to 2 years. Male and female rats developed highly significant incidences of hepatocellular carcinomas. The carcinomas varied from well-differentiated to undifferentiated. There was a highly significant increase in carcinomas of the ovary in treated female rats. Lymphosarcomas were also increased in DDT-treated male rats.
D000818:Animals; D003634:DDT / Q000633:toxicity*; D005260:Female; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology; D008175:Lung Neoplasms / Q000139:chemically induced; D008228:Lymphoma, Non-Hodgkin / Q000139:chemically induced; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced; D010051:Ovarian Neoplasms / Q000139:chemically induced; D051381:Rats
D003634:DDT