Preliminary study of pharmacokinetics and metabolism of sodium 2-n-propylpentanoate in pig and human.
The pharmacokinetics of sodium 2-n-propyl-pentanoate have been studied in pig and human. The drug is excreted in the human urine as a mixture of glucuronide and other unidentified conjugates. It appears that no other conjugates can be found in pig's urine. Treatment with sulfatase does not identify sulfate-conjugates in human urine. Coadministration of acetyl salicylic acid (ASA) increases the fraction of glucuronide and other conjugates in human urine. The rate of renal excretion of the drug appears to be increased during concomitant administration of ASA.
D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D005231:Fatty Acids, Unsaturated / Q000097:blood / Q000378:metabolism* / Q000652:urine; D005965:Glucuronates / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D008297:Male; D013552:Swine
D005231:Fatty Acids, Unsaturated; D005965:Glucuronates; D001241:Aspirin