Sugar-oximes, new potential antidotes against organophosphorus poisoning.
In attempt to improve distribution and transport qualities of antidotes against organophosphorus poisoning, a new series of pyridine aldoximes linked to glucose moiety were synthesized and studied both in vivo and in vitro. Preliminary results describing the biological activity of the new compounds are presented and discussed in this report.
D000818:Animals; D000931:Antidotes / Q000138:chemical synthesis*; D002801:Cholinesterase Reactivators / Q000138:chemical synthesis / Q000494:pharmacology; D002802:Cholinesterases / Q000378:metabolism; D004524:Eels; D005947:Glucose / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D051379:Mice; D062025:Organophosphate Poisoning; D011220:Pralidoxime Compounds / Q000138:chemical synthesis* / Q000494:pharmacology
D000931:Antidotes; D002801:Cholinesterase Reactivators; D011220:Pralidoxime Compounds; D002802:Cholinesterases; D005947:Glucose