Cell wall analysis of an adenine-requiring mutant of the yeast-like form of Paracoccidioides brasiliensis strain IVIC Pb9.
An adenine-requiring mutant of Paracoccidioides brasiliensis strain IVIC Pb9 was isolated after treatment of the yeast-like (Y) form with nitrosoguanidine. Cell wall analysis of this mutant (strain IVIC Pb141) showed an increase in the amount of alpha-1,3-glucan and a virtual disappearance of the antigenic galactomannan. At the same time, a higher degree of virulence was observed for the mutant. These results agree with the hypothesis presented before (16) about a relationship between cell wall polysaccharides and pathogenicity in P. brasiliensis.
D000225:Adenine / Q000096:biosynthesis; D000596:Amino Acids / Q000032:analysis; D000606:Amino Sugars / Q000032:analysis; D002473:Cell Wall / Q000032:analysis; D005658:Fungi / Q000032:analysis*; D006601:Hexoses / Q000032:analysis; D008055:Lipids / Q000032:analysis; D009154:Mutation; D010228:Paracoccidioides / Q000032:analysis* / Q000235:genetics / Q000472:pathogenicity
D000596:Amino Acids; D000606:Amino Sugars; D006601:Hexoses; D008055:Lipids; D000225:Adenine