[Effect of beta-adrenergic blockade on acid-base balance in experimental hypertension].
On rats with experimental hypertension by method of Selye, modified by Kolarova, distributed in two groups--treated by obsidan and untreated, the following parameters on the 1st and the 3rd month after the operation were studied: pH, BB, SB, AB, BE, PaCO2, TCO2, PaO2, and SaO2. In the hypertonic animals we establish a decompensated metabolic acidosis on the 1st month and a metabolic acidosis with a marked respiratory compensation on the 3rd month. The hypertonic animals, treated by obsidan, demonstrate a sharp tendency to normalise the parameters of the acid-base status on the 1st month and normal values on the 3rd. The protective obsidan effect observed on the hypertonic rat we discuss as a result of metabolic and functional influences of the beta-adrenergic blockers.
D000138:Acidosis / Q000209:etiology*; D000818:Animals; D006973:Hypertension / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D007668:Kidney / Q000503:physiopathology; D008168:Lung / Q000503:physiopathology; D008297:Male; D011433:Propranolol / Q000627:therapeutic use*; D051381:Rats
D011433:Propranolol
Vliianie na beta-adrenergichnata blokada vurkhu kiselinno-alkalnoto ravnovesie pri eksperimentalna khipertoniia.