Chemotherapeutically active nitro-derivatives. 4. 5-Nitroimidazoles (Part IV).
16 novel 1-methyl-5-nitroimidazoles substituted at 2-position were examined for activity against various protozoa, in particular trichomonads in NMRI mice and amebae in golden hamsters. Six of the compounds proved to be superior to metronidazole and one superior to tinidazole against trichomonads. The compounds exhibited no marked effect against amebae and trypanosomes. The structure-activity relationships of the new compounds are discussed.
D000562:Amebiasis / Q000188:drug therapy*; D000818:Animals; D006224:Cricetinae; D008647:Mesocricetus; D051379:Mice; D009593:Nitroimidazoles / Q000627:therapeutic use*; D013329:Structure-Activity Relationship; D014245:Trichomonas Infections / Q000188:drug therapy*; D014352:Trypanosomiasis / Q000188:drug therapy*
D009593:Nitroimidazoles