The protein-sparing effect of carbohydrate. 2. The role of insulin.
1. In five experiments with growing female pigs of 38-63 kg, insulin (2 mU/kg) per min) and glucose (9-17 mg/kg per min) were infused continuously for 3-7 d. In three further experiments, glucose (9 mg/kg per min) was infused alone for 5 d. 2. In response to the combined infusion, plasma insulin increased 2-7-fold, plasma glucose decreased, on average, by 50% and plasma urea concentration was reduced by 40%. Urinary excretion of urea and nitrogen decreased after the first day of infusion to values averaging 70% of control levels. 3. The infusion of glucose alone provoked only a small increase in plasma insulin. The reduction of urinary urea and of N excretion were approximately 25% of those observed with the combined infusions.
D000818:Animals; D001786:Blood Glucose; D004040:Dietary Carbohydrates; D005260:Female; D007328:Insulin / Q000097:blood / Q000494:pharmacology*; D009584:Nitrogen / Q000652:urine; D011506:Proteins / Q000378:metabolism*; D013552:Swine; D014508:Urea / Q000652:urine
D001786:Blood Glucose; D004040:Dietary Carbohydrates; D007328:Insulin; D011506:Proteins; D014508:Urea; D009584:Nitrogen