[The toxicity of lincomycin. Two i.v. applications of 6 g. each to a 10 year old girl without toxic symptoms].
A 10-year old girl (34.5 kg) being treated at our clinic for osteomyelitis erroneously received an overdose of lincomycin. On a single day she was given 2 infusions containing 6 g of lincomycin each, which corresponds to a dose of 343 mg/kg of body weight. There was an interval of 10 h between infusions. Apart from fatigue and unpleasant taste sensation, she demonstrated no signs of intoxication. None of the laboratory parameters (GOT, GPT, gamma-GT, LDH, G-LDH, LAP, alkaline phosphatase and CK; furthermore, the concentrations of glucose, BUN, creatinine, uric acid and bilirubin) offered any evidence of toxic organ damage. Osteomyelitis in children demands extremely high doses of antibiotics. In view of this fact, the therapeutic range of a substance is of utmost clinical interest.
D002648:Child; D005260:Female; D006801:Humans; D008034:Lincomycin / Q000097:blood / Q000506:poisoning* / Q000627:therapeutic use; D008508:Medication Errors; D010019:Osteomyelitis / Q000188:drug therapy
D008034:Lincomycin
Zur Frage der Toxizität von Lincomycin. Zweimalige i.v. Applikation von je 6 g Lincomycin bei einem 10jährigen Mädchen ohne Zeichen einer Intoxikation.