Adrenal dehydrogenases in alloxan diabetic rats following continuous exposure to light.
The enzymes delta5-3beta-hydroxysteroid dehydrogenase delta5-3beta-HSD) and glucose-6-phosphate dehydrogenase (G-6-PDH) were demonstrated histochemically in the adrenal cortex of female rat. The activities of these enzymes were increased significantly in the alloxan-treated rats kept in LD (light: darkness) cycles of 10:14 h. Continuous light exposure to diabetic animals appeared to decrease delta5-3beta-HSD and g-6-PDH in comparison to the diabetic rats kept in 10 h illumination. The evidence indicates that suppression of adrenal steroidogenesis in diabetic rats after exposure to continuous light is due to the alteration of pentose phosphate pathway.
D000302:Adrenal Cortex / Q000201:enzymology*; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology*; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D006913:Hydroxysteroid Dehydrogenases / Q000378:metabolism; D008027:Light; D008029:Lighting; D010088:Oxidoreductases / Q000378:metabolism*; D051381:Rats; D013997:Time Factors
D010088:Oxidoreductases; D006913:Hydroxysteroid Dehydrogenases; D005954:Glucosephosphate Dehydrogenase