N-Acetylcysteine and mucociliary activity in mammalian airways.
The effect of N-acetylcysteine on mucus trasnport velocity (MV), ciliary beat frequency (CBF), mucus production (MP), mucus lysis and on the micro-morphology of the secretory cells was studied in mammalian airways. The results showed that: 1. MV increased in healthy rats and rabbits, as well as in bronchitic rats, after concentrations as low as 10(-14) g/ml. Depression of MV occurred first at 10(-6) and 10(-5) g/ml  in healthy and bronchitic animals, respectively. 2. CBF was stimulated at concentrations between 10(-12) and 10(-10) g/ml and decreased at concentrations above 10(-8) g/ml. 3. MP increased by approximately 100% over control values. 4. Lysis of stagnant mucus was evident first at a concentration of 10(-11) g/ml after 15 min incubation. 5. TEM confirmed the increased activity of the mucus secreting cells and showed that no pathological changes occurred within the cell following incubation at 10(-7) g/ml for up to 150 min. The importance of these findings on the overall mucociliary function is discussed.
D000111:Acetylcysteine / Q000494:pharmacology*; D000818:Animals; D001980:Bronchi / Q000648:ultrastructure; D002923:Cilia / Q000187:drug effects*; D005260:Female; D009093:Mucus / Q000187:drug effects*; D009976:Orthomyxoviridae Infections / Q000503:physiopathology; D011817:Rabbits; D051381:Rats
D000111:Acetylcysteine