Intraphypothalamic implants of testosterone or dihydrotestosterone in neonatal female rats with reference to induction of sterility.
Implants of paraffin micropellets containing about 5 microgram 5 alpha-dihydrotestosterone (DHT) into the hypothalamus of 5-day-old female rats were without effect on the sexual differentiation of the brain. By contrast, approximately the same amount of testosterone propionate (TP) given as subcutaneous or intrahypothalamic micropellets masculinized the female brain. In the light of these results as well as the author's previous findings that an antiestrogen implanted into the hypothalamus of neonatal female rats failed to block masculinization by subcutaneous injection of TP, the possibility cannot be excluded that testosterone is capable of masculinizing the brain of neonatal females without being converted into estrogens.
D000818:Animals; D000831:Animals, Newborn; D013196:Dihydrotestosterone / Q000008:administration & dosage*; D004343:Drug Implants; D005260:Female; D007031:Hypothalamus; D007247:Infertility, Female / Q000139:chemically induced*; D009929:Organ Size; D010053:Ovary / Q000033:anatomy & histology; D051381:Rats; D013739:Testosterone / Q000008:administration & dosage*
D004343:Drug Implants; D013196:Dihydrotestosterone; D013739:Testosterone