Experiments on the influence of an aromatic retinoid on the chemical carcinogenesis in rats by butyl-butanol-nitrosamine and 1,2-dimethylhydrazine.
In male Sprague-Dawley rats it was tested whether the induction of carcinomas of the bladder by butyl-butanol-nitrosamine (BBN) and the induction of carcinomas of the colon by 1,2-dimethylhydrazine (DMH) could be influenced by an aromatic retinoid ethyl-allyl-trans-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoate (RO 10-9359). Neither an inhibitory nor an enhancing effect of the retinoid on carcinogenesis was observed.
D000818:Animals; D000970:Antineoplastic Agents; D002273:Carcinogens; D003043:Cocarcinogenesis; D004127:Dimethylhydrazines / Q000037:antagonists & inhibitors / Q000633:toxicity; D004347:Drug Interactions; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000517:prevention & control; D009602:Nitrosamines / Q000037:antagonists & inhibitors / Q000633:toxicity; D051381:Rats; D014801:Vitamin A / Q000031:analogs & derivatives* / Q000627:therapeutic use / Q000633:toxicity
D000970:Antineoplastic Agents; D002273:Carcinogens; D004127:Dimethylhydrazines; D009602:Nitrosamines; D014801:Vitamin A