[Identification of thyroglobulin-binding cells in the blood of Hashimoto patients (author's transl)].
We developed a new method for demonstration and enumeration of antigen-binding cells, the principle and application of this method is demonstrated using peripheral blood lymphoid cells from Hashimoto patients, non-Hashimoto, non Graves' disease goiter patients and in patients without thyroid disease. A significantly higher number of thyroglobulin-binding cells was observed in the peripheral blood of Hashimoto patients as compared to members of the two other groups. The results of the FICA-tests were compared to conventional serological data of the individual patients.
D000368:Aged; D000941:Antigens / Q000032:analysis; D001666:Binding Sites, Antibody; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000032:analysis; D008875:Middle Aged; D012397:Rosette Formation; D013954:Thyroglobulin / Q000276:immunology*; D013967:Thyroiditis, Autoimmune / Q000097:blood / Q000276:immunology*
D000941:Antigens; D013954:Thyroglobulin
Identifikation thyreoglobulinbindender Zellen im Blut von Hashimoto-Patienten.