Anti-inflammatory activity in oak gall extracts.
A method for the purification of the Hungarian oak gall extracts containing anti-inflammatory activity is described. The anti-inflammatory activity of the purified extract was tested in the carrageenan-induced rat paw edema and in rat polyarthritis induced by mycobacterial adjuvant. In doses of 4.3 and 8.5 mg/kg i.p., the extract inhibited dose-dependently the formation of paw edema induced by carrageenan in rats. When rats were treated daily from 3 days prior to and 16 days after the injection of the mycobacterial adjuvant, the severity of the polyarthritic symptoms was significantly reduced.
D000818:Animals; D000893:Anti-Inflammatory Agents; D001169:Arthritis, Experimental / Q000503:physiopathology; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000503:physiopathology; D008297:Male; D009161:Mycobacterium / Q000276:immunology; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D014197:Trees
D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D002351:Carrageenan