title: Studies of absorption, distribution and excretion of 2,6-xylidide of 2-pyridone-3-carboxylic acid (isonixine).
abstract: The absorption, tissue distribution and excretion of 14C-labelled 2,6-xylidide of 2-pyridone-3-carboxylic acid (isonixine) have been investigated in the rat after intragastric and intraduodenal administration. Isonixine was rapidly absorbed from the gastro-intestinal tract. The half-life of absorption was 3.15 h. The product was soon distributed in the whole organism. The radioactive metabolites were excreted rapidly, the major route being the urinary tract (85% in 72 h). There was no evidence of long-term storage of isonixine in the body. These results were confirmed by autoradiographic studies in the mouse after oral administration.
mesh_terms: D000813:Anilides / Q000008:administration & dosage / Q000378:metabolism / Q000652:urine; D000818:Animals; D001646:Bile / Q000378:metabolism; D001711:Biotransformation; D004386:Duodenum; D006207:Half-Life; D007408:Intestinal Absorption; D007441:Intubation, Gastrointestinal; D008297:Male; D009539:Nicotinic Acids / Q000008:administration & dosage / Q000378:metabolism* / Q000652:urine; D051381:Rats; D013270:Stomach; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D000813:Anilides; D009539:Nicotinic Acids