Bone histomorphometry in patients with chronic renal failure: effect of 1alpha-hydroxyvitamin D3.
Morphometric and dynamic studies of iliac crest bone biopsies were carried out in twelve patients with chronic renal failure (six on chronic haemodialysis and six with renal insufficiency) before and after 6 months of 1alpha-hydroxyvitamin D3 treatment. Pre-treatment biopsies showed signs of osteomalacia and hyperparathyroidism. Biopsies taken during treatment showed changes towards normality, indicating a beneficial effect of 1alpha-hydroxyvitamin D3.
D000328:Adult; D001706:Biopsy; D005260:Female; D006801:Humans; D006887:Hydroxycholecalciferols / Q000627:therapeutic use*; D006962:Hyperparathyroidism, Secondary / Q000473:pathology; D007085:Ilium / Q000473:pathology*; D007676:Kidney Failure, Chronic / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010018:Osteomalacia / Q000473:pathology; D006435:Renal Dialysis
D006887:Hydroxycholecalciferols