Passive immunotherapy of established tumors with syngeneic antitumor serum in combination with immunopotentiators.
The possibility of passive therapy of 6 approximately 8-day established tumors with syngeneic antitumor antiserum was tested using (1) combination  of the antiserum and immunopotentiators, (2) combination of the antiserum and inflammatory agents, and (3) repeated injections of antiserum. Therapeutic effect on an ascites tumor was seen using antiserum in combination with BCG or lipopolysaccharide, or less clearly with carrageenan. Combinations of antiserum and PS-K, histamine, or croton oil did not have a synergistic therapeutic effect, but repeated injection of a small amount of antiserum did have a therapeutic effect on established peritoneal and subcutaneous tumors.
D000818:Animals; D000912:Antibodies, Neoplasm / Q000008:administration & dosage*; D001500:BCG Vaccine / Q000494:pharmacology*; D002351:Carrageenan / Q000494:pharmacology; D003436:Croton Oil / Q000494:pharmacology; D004306:Dose-Response Relationship, Immunologic; D007116:Immunization, Passive; D007167:Immunotherapy; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000276:immunology / Q000628:therapy*; D051379:Mice; D008809:Mice, Inbred C3H; D011134:Polysaccharides / Q000494:pharmacology
D000912:Antibodies, Neoplasm; D001500:BCG Vaccine; D008070:Lipopolysaccharides; D011134:Polysaccharides; D003436:Croton Oil; D002351:Carrageenan