Genetics of cell-surface antigens: regional mapping of three components of the human cell-surface antigen complex, AL, on chromosome 11.
Cytogenetic analysis has been performed on a series of deletion mutations on human chromosome 11 of AL hybrid clones in which specific markers have been lost as a result of treatment with mutagenic agents. Such analysis has localized the three previously identified components of the AL cell-surface antigen complex to the indicated regions of chromosome 11: a1 and a3:11p13 leads to 11pter; a2:11q13 leads to 11qter. Using these methodologies human lactic dehydrogenase A localization on the short arm as reported by others has been confirmed. Evidence is presented provisionally assigning this gene to 11p13 leads to 11pter.
D000941:Antigens / Q000235:genetics*; D002462:Cell Membrane / Q000276:immunology; D002874:Chromosome Mapping; D002906:Chromosomes, Human, 6-12 and X; D002999:Clone Cells; D005796:Genes; D006801:Humans; D006822:Hybrid Cells; D007770:L-Lactate Dehydrogenase / Q000235:genetics; D009154:Mutation
D000941:Antigens; D007770:L-Lactate Dehydrogenase