Comparative studies on the influence of some radioprotectors on the postirradiation hydrolytic function of subcellular fractions of pancreas.
Comparative studies on the influence of the two radioprotectors Fenchlorfos and cysteamine on the hydroproteolytic activity of pancreatic subcellular fractions of rats were carried out. The animals were irradiated with the single dose of 800 R of X-rays. Biochemical estimation of lipase, beta-glucuronidase, acid phosphatase and catheptic (caseinolytic) activity were done 24 hours after exposition. The two radioprotective substances have a lot of common in their action against hydrolytic activity. They induce the decrease of some enzymes of subcellular fractions we checked both in control as well as in irradiated groups. The ambivalent influence of Trichlorfon on the lipase activity in granules and supernatant fraction seems to be of interest.
D000818:Animals; D003543:Cysteamine / Q000494:pharmacology; D005260:Female; D006868:Hydrolysis; D008297:Male; D010179:Pancreas / Q000187:drug effects / Q000528:radiation effects*; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D051381:Rats; D013347:Subcellular Fractions / Q000187:drug effects / Q000528:radiation effects*; D014236:Trichlorfon / Q000494:pharmacology
D011837:Radiation-Protective Agents; D003543:Cysteamine; D014236:Trichlorfon