Decreased sensitivity to insulin in white adipose tissue from adrenalectomised rats.
The ability of insulin to increase both [14C]-glucose incorporation into fatty acids and pyruvate dehydrogenase activity in incubated rat epididymal adipose tissues was considerably lessened after adrenalectomy. Insulin antagonism of adrenaline-stimulated lipolysis in isolated fat cells was abolished after adrenalectomy. Percentage stimulation of lipolysis above basal by adrenaline was not appreciably altered by adrenalectomy.
D000273:Adipose Tissue / Q000378:metabolism*; D000315:Adrenalectomy; D000818:Animals; D004822:Epididymis; D004837:Epinephrine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D005227:Fatty Acids / Q000096:biosynthesis; D005990:Glycerol / Q000378:metabolism; D007328:Insulin / Q000494:pharmacology*; D008053:Lipid Mobilization / Q000187:drug effects*; D008297:Male; D011768:Pyruvate Dehydrogenase Complex / Q000378:metabolism*; D051381:Rats
D005227:Fatty Acids; D007328:Insulin; D011768:Pyruvate Dehydrogenase Complex; D005990:Glycerol; D004837:Epinephrine