title: [Studies on the disposition of meproscillarin in rat and dog (author's transl)].
abstract: The disposition of 14-hydroxy-3beta-[(4-O-methyl-alpha-L-rhamnopyranosyl)oxy]-14beta-bufa-4,20,22-trienolide (meproscillarin, Clift) formed by methylation of proscillaridin was tested in rats and dogs. Meproscillarin is better absorbed than proscillaridin. The drug is primarily eliminated via the bile. After oral administration 6% of the dose were excreted with urine by the rat and 3% by the dog. The main metabolite in the bile was shown to be a glucuronide of meproscillarin.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001646:Bile / Q000378:metabolism; D002301:Cardiac Glycosides / Q000008:administration & dosage / Q000378:metabolism*; D004285:Dogs; D005243:Feces / Q000032:analysis; D005260:Female; D007275:Injections, Intravenous; D008297:Male; D051381:Rats; D013997:Time Factors
chemical_list: D002301:Cardiac Glycosides
vernacular_title: Untersuchungen zur Disposition von Meproscillarin an den Spezies Ratte und Hund.