title: Further studies on gonadotropin-inhibiting substances excreted in human urine.
abstract: Partial separtion of human urinary substances which have properties to suppress the ovulation induced by PMS and HCG in mice was attempted by gel filtration on Sephadex G-100 and ultrafiltration using the Amicon Diaflo membranes UM-2 and UM-10. In addition to a thermostable inhibitor which has a molecular weight more than 10,000, the presence of heat-labile inhibitor with a molecular weight less than 1,000 was newly demonstrated.
mesh_terms: D000818:Animals; D006063:Chorionic Gonadotropin / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D005260:Female; D006064:Gonadotropins, Equine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D006358:Hot Temperature; D006801:Humans; D008297:Male; D051379:Mice; D008970:Molecular Weight; D010060:Ovulation / Q000187:drug effects*; D014556:Urine / Q000032:analysis*
chemical_list: D006063:Chorionic Gonadotropin; D006064:Gonadotropins, Equine