title: [Synthesis of Butyl 6alpha-Fluoro-11beta-hydroxy-16alpha-methyl-3,20-dioxo-1,4-pregnadien-21-oate (Fluocortin Butylester) (author's transl)].
abstract: Among the metabolites of fluocortolone (1) there was found the alpha-keto acid 4a. This acid, as well as the esters 4b--4k were synthesized and the butyl ester 4c was chosen for local anti-inflammatory therapy.
mesh_terms: D005448:Fluocortolone / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D008722:Methods; D011244:Pregnadienediols / Q000138:chemical synthesis*
chemical_list: D011244:Pregnadienediols; D005448:Fluocortolone
vernacular_title: Synthese von 6alpha-Fluor-11beta-hydroxy-16alpha-methyl-3,20-dioxo-1,4-pregnadien-21-säure-butylester (Fluocortin-butylester).