[Neurophoarmacologic profile of an aminotetraline derivative].
The authors examined the effect of the piperasine derivative of 2-aminotetraline N-(trans-3-hydroxy--1,2,3,4-tetrahydro-2-naphthl)--N--(3-oxy-3-phenyl 1--2 methyl propyl)--piperasine (P11) on nobred white mice and rats of the Wistar strain and found interesting and specific neuropharmacological activity. The compound P11 inhibits the central nervous system, diminishes the muscular tonus, attenuates aggressiveness, potentiates hexobarbital sleep, possesses its own analgetic activity, but weakens the morphine analgesia. Without changing spontaneous motor activity the compound sharply lowers the motor activity, raised by phenamine as well as phenamine toxicity. P11 enhances the reserpine and apomomorphine hypothermia and phenamine hyperthermia. The neurological effects of the compound P11 are discussed, taking into consideration its structural similarity with dopamine and its manifested beta adrenoblocking properties.
D000661:Amphetamine / Q000494:pharmacology; D000700:Analgesics; D000818:Animals; D001058:Apomorphine / Q000037:antagonists & inhibitors; D002490:Central Nervous System / Q000187:drug effects; D004347:Drug Interactions; D006591:Hexobarbital / Q000494:pharmacology; D051379:Mice; D009020:Morphine / Q000037:antagonists & inhibitors; D009043:Motor Activity / Q000187:drug effects; D009129:Muscle Tonus / Q000187:drug effects; D009284:Naphthols / Q000494:pharmacology*; D009420:Nervous System / Q000187:drug effects*; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D012110:Reserpine / Q000037:antagonists & inhibitors; D013331:Strychnine / Q000037:antagonists & inhibitors
D000700:Analgesics; D009284:Naphthols; D010879:Piperazines; D009020:Morphine; D012110:Reserpine; D006591:Hexobarbital; D000661:Amphetamine; D013331:Strychnine; D001058:Apomorphine; D010433:Pentylenetetrazole
Nevrofarmakologichen profil na edno aminotetralinovo proizvodno.