[Autoimmune response following administration of a protein preparation from the caudate nuclei of cattle brains to rabbits].
Plasma membranes of bovine caudate nuclei were solubilized by means of Triton X-100. Detergent-extracted membrane proteins were separated by chromatography on DEAE-cellulose and the affinity adsorbent proposed for the isolation of nicotinic cholinergic receptor protein (N-ChR) from Torpedo electrical organ. Half of the rabbits immunized with purified protein preparation developed a syndrome of myasthenia type. This effect resembled the autoimmune response to N-ChR from fish electrical organs. It is assumed that the N-ChR present in the caudate nucleus has antigen determinants similar to N-ChRs of the electrical organs and skeletal muscles.
D000818:Animals; D001323:Autoantibodies; D002417:Cattle / Q000276:immunology; D002421:Caudate Nucleus / Q000276:immunology*; D002462:Cell Membrane / Q000276:immunology; D004557:Electric Organ / Q000276:immunology; D006967:Hypersensitivity / Q000209:etiology / Q000276:immunology; D008565:Membrane Proteins / Q000276:immunology; D009132:Muscles / Q000276:immunology; D009135:Muscular Diseases / Q000209:etiology* / Q000276:immunology; D009419:Nerve Tissue Proteins / Q000276:immunology*; D011817:Rabbits
D001323:Autoantibodies; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins
Autoimmunnyĭ otvet pri vvedenii krolikam belkovogo preparata iz khvostatykh iader mozga krupnogo rogatogo skota.