Effect of phentolamine on perineal muscle EMG activity in paraplegia.
The effect of the alpha-adrenergic blocking agent, phentolamine, was studied on the perineal muscle EMG in 3 paraplegic patients. The drug reduced the EMG activity in these patients. This suggests that the normal suppression of external sphincter activity during micturition might be related to a reduction in the external sphincter activity supplied by the sympathetic system.
D004576:Electromyography; D006801:Humans; D009132:Muscles / Q000187:drug effects / Q000503:physiopathology*; D010264:Paraplegia / Q000503:physiopathology*; D010502:Perineum / Q000187:drug effects / Q000503:physiopathology*; D010646:Phentolamine / Q000494:pharmacology*; D001743:Urinary Bladder / Q000187:drug effects / Q000503:physiopathology
D010646:Phentolamine