title: [Effect of diuretics (diacarb and lasix) on the experimental antitumor activity, toxicity and pharmacokinetics of the antibiotic, olivomycin].
abstract: Diacarb or lasix in combination with olivomycin increased the antibiotic antiblastomic activity and toxicity when used for the course treatment of mice with transplanted lymphosarcoma LIO-I. The chemotherapeutic indices of such combinations did not differ from those of olivomycin used alone. Diacarb decreased excretion of olivomycin with the urine in healthy mice, while lasix increased it.
mesh_terms: D000086:Acetazolamide / Q000627:therapeutic use*; D000818:Animals; D004231:Diuresis / Q000187:drug effects; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D005260:Female; D005665:Furosemide / Q000627:therapeutic use*; D007700:Kinetics; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy; D009848:Olivomycins / Q000494:pharmacology / Q000627:therapeutic use* / Q000633:toxicity; D051381:Rats
chemical_list: D004338:Drug Combinations; D009848:Olivomycins; D005665:Furosemide; D000086:Acetazolamide
vernacular_title: Vliianie diuretikov (diakarba i laziksa) na protivoopukholevuiu aktivnost', toksichnost' i farmakokinetiku antibiotika olivomitsina v éksperimente.