[The effect of albumin and furosemide administration in children with primary nephrotic syndrome (author's transl)].
The authors have studied the effect of the infusion of sodium poor albumin on the primary nephrotic syndrome edema in children. The albumin dose used was 1 g per kilo, administered intravenously during four hours. A variable weight loss of 5.7% to 8.3% related to the initial weight was observed. The urinary volume increased considerably during the study period, as well as the urinary sodium excretion and creatinine clearance. The study of the relation of the urinary Na/K suggests that the secondary hyperaldosteronism is blocked by the albumin infusion probably due to an increase in the intravascular volume. They have concluded that the administration of sodium poor albumin whether or not associated to diuretics is effective in controlling the Primary Nephrotic Syndrome edema in children.
D000293:Adolescent; D000418:Albumins / Q000008:administration & dosage* / Q000627:therapeutic use; D001835:Body Weight / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D004039:Diet, Sodium-Restricted; D004231:Diuresis / Q000187:drug effects; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D005665:Furosemide / Q000008:administration & dosage*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D009404:Nephrotic Syndrome / Q000188:drug therapy* / Q000652:urine; D011188:Potassium / Q000652:urine; D012964:Sodium / Q000652:urine
D000418:Albumins; D005665:Furosemide; D012964:Sodium; D011188:Potassium
Efeito da infusão de albumina humana e furosemide em criancas com síndrome nefrótico primário.