[Change in plasma renin activity in patients with hypertension and healthy persons after furosemide intake].
Blood plasma renin activity was studied by the radioimmune method in clino- and orthostatism in 36 males with hypertensive disease and in 15 healthy males before and after 3-day medication with furosemide in a daily dose of 120 mg under in-patient conditions. Renin activity proved to be higher in double stimulation (in orthostatism after furosemide intake) than in orthostatism before the intake of the drug. Diversity was revealed between patients with different stages of hypertensive disease. Stage IB of the disease was characterized by increased renin activity in orthostatism and marked reaction to stimulation with furosemide. In stage IIB, on the contrary, renin activity was low and the reaction to stimulation with furosemide weak. Hypotensive effect after intake of furosemide was observed in patients with IIB stage of hypertensive disease.
D000293:Adolescent; D000328:Adult; D005665:Furosemide / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D011187:Posture; D012083:Renin / Q000097:blood*; D013268:Stimulation, Chemical
D005665:Furosemide; D012083:Renin
Izmenenie aktivnosti renina v plazme krovi u bol'nykh gipertonicheskoĭ bolezn'iu i zdorovykh liudeĭ posle priema furosemida.