[Interaction of sibiromycin with soluble chromatin from the cells of murine NK/LI lymphadenosis].
Interaction of sibiromycin with chromatin from NK/Li cells was studied. It was shown that the chromatin proteins had no significant effect on the amount of the antibiotic firmly bound with DNA. The difference observed in the kinetics of the sibiromycin interaction with chromatin and DNA from NK/Li cells was not induced by replacement of a part of the DNA bound proteins. Possibly the chromatin proteins hampered formation of DNA conformation necessary for sibiromycin binding.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000378:metabolism*; D002843:Chromatin / Q000378:metabolism*; D004273:DNA, Neoplasm / Q000378:metabolism; D004347:Drug Interactions; D066298:In Vitro Techniques; D007700:Kinetics; D008223:Lymphoma / Q000378:metabolism*; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000378:metabolism; D011485:Protein Binding / Q000187:drug effects; D012995:Solubility
D000903:Antibiotics, Antineoplastic; D002843:Chromatin; D004273:DNA, Neoplasm
Vzaimodeĭstvie sibiromitsina s rastvorimym khromatinom iz kletok limfadenoza mysheĭ NK/LI.