Excretion of methyl mercury in rat bile: the effect of diethylmaleate, cyclohexene oxide and acrylamide.
Diethylmaleate, cyclohexene oxide and acrylamide administered intraperitoneally to rats, have been shown markedly to inhibit biliary excretion of methyl mercury. Simultaneously the sulphhydryl and sulphide content of the bile decreases. These results probably reflect the conjugation of acrylamide, diethylmaleate and cyclohexene oxide to glutathione in the liver, thereby blocking the biliary excretion of methyl mercury. A high concentration of liver glutathione seems to be a prerequisite for the normal translocation of methyl mercury from liver to bile. These results indicate that methyl mercury is transported from liver to bile as a glutathione complex.
D000178:Acrylamides / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D001646:Bile / Q000032:analysis; D003510:Cyclohexanes / Q000494:pharmacology*; D004852:Epoxy Compounds / Q000494:pharmacology*; D004988:Ethers, Cyclic / Q000494:pharmacology*; D005978:Glutathione / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D008298:Maleates / Q000378:metabolism / Q000494:pharmacology*; D008767:Methylmercury Compounds / Q000378:metabolism*; D051381:Rats; D013438:Sulfhydryl Compounds / Q000378:metabolism; D013440:Sulfides / Q000378:metabolism; D013997:Time Factors
D000178:Acrylamides; D003510:Cyclohexanes; D004852:Epoxy Compounds; D004988:Ethers, Cyclic; D008298:Maleates; D008767:Methylmercury Compounds; D013438:Sulfhydryl Compounds; D013440:Sulfides; D005978:Glutathione