Prostaglandins and congeners. 16. Synthesis and bronchodilator activity of dl-11-doexy-3-thiaprostaglandins.
The interesting bronchodilator activity of certain dl-11-deoxy-3-thiaprostaglandins and their preparation by the conjugate addition of appropriately substituted (E)-1-alkenyllithio cuprate reagents to requisite cyclopentenones are described.
D000109:Acetylcholine / Q000037:antagonists & inhibitors; D000818:Animals; D001986:Bronchial Spasm / Q000503:physiopathology; D001993:Bronchodilator Agents / Q000138:chemical synthesis*; D005260:Female; D006168:Guinea Pigs; D006633:Histamine Antagonists / Q000138:chemical synthesis; D008297:Male; D011459:Prostaglandins E, Synthetic / Q000138:chemical synthesis* / Q000494:pharmacology; D012702:Serotonin Antagonists / Q000138:chemical synthesis; D013329:Structure-Activity Relationship
D001993:Bronchodilator Agents; D006633:Histamine Antagonists; D011459:Prostaglandins E, Synthetic; D012702:Serotonin Antagonists; D000109:Acetylcholine