title: Medullary sponge kidney: abnormalities of renal tubular and glomerular function, and their relationship to clinical features.
abstract: This study confirms that medullary sponge kidney (MSK) has a good prognosis, but there is a considerable morbidity in patients with renal calcification; they suffer renal colic, ureteric obstruction, and frequently need operation. There is a high incidence of urinary infection in women. On follow-up, glomerular function is well maintained, although careful testing shows a mild depression of glomerular filtration rate in at least 40%. Proximal tubular function is normal, but abnormalities of distal tubular function are often seen: acidification defects occur in 24% and are associated with nephrocalcinosis, poor urine concentrating ability, and diminished glomerular function. Urine concentration defects occur in 73% and are probably secondary to nephrocalcinosis. Hypercalciuria was present in 19% and was not related to other defects.
mesh_terms: D002118:Calcium / Q000378:metabolism; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007671:Kidney Concentrating Ability; D007678:Kidney Glomerulus / Q000503:physiopathology*; D007679:Kidney Medulla / Q000473:pathology; D007684:Kidney Tubules / Q000503:physiopathology*; D008297:Male; D007691:Medullary Sponge Kidney / Q000150:complications / Q000378:metabolism / Q000503:physiopathology*; D009397:Nephrocalcinosis / Q000209:etiology; D011379:Prognosis; D014552:Urinary Tract Infections / Q000209:etiology
chemical_list: D002118:Calcium