A dominant lethal study in male rats after repeated exposures to vinyl chloride or vinylidene chloride.
Male CD rats were exposed 6 hr/day for 5 days/wk to 0, 50, 250, or 1,000 ppm of vinyl chloride or 55 ppm of vinylidene chloride. Starting on week 11 of exposure, these males were mated with untreated females. There was no evidence of either preimplantation loss or postimplanation loss in pregnant females that resulted from these matings. Consequently, it was concluded that these exposures did not produce germinal mutation, as manifested by a dominant lethal effect, in male rats.
D000818:Animals; D002875:Chromosomes / Q000187:drug effects*; D004000:Dichloroethylenes / Q000633:toxicity*; D004781:Environmental Exposure; D005804:Genes, Lethal; D006843:Hydrocarbons, Chlorinated / Q000633:toxicity*; D008297:Male; D009153:Mutagens / Q000633:toxicity*; D051381:Rats; D013094:Spermatozoa / Q000187:drug effects*; D014752:Vinyl Chloride / Q000633:toxicity*; D014753:Vinyl Compounds / Q000633:toxicity*
D004000:Dichloroethylenes; D006843:Hydrocarbons, Chlorinated; D009153:Mutagens; D014753:Vinyl Compounds; D014752:Vinyl Chloride