[Comparative characteristics of the action of sydnocarb, phenamine and caffeine on multiple alteration in the orientation of the avoidance response in rats].
The ability of rats to alter orientation of the avoidance response in an Y-shaped maze was determined. Sydnocarb (20 mg/kg) improved the reversal learning of the animals, shortened the latent reaction periods and did not upset passive avoidance. Amphetamine (0.5 mg/kg) and caffein (25 mg/kg) shortened the latency of reactions, but did not affect the reversal learning. In large doses (2 and 5 mg/kg) amphetamine distinctly disturbed the reversal learning, while sydnocarb (50 mg/kg) did not impair the alteration of the avoidance response. In rats poorly amenable to reversal learning during control testing syndnocarb facilitated the alteration of the habit better than other drugs. In animals well amenable to reversal learning, in contrast to amphetamine and caffein, it did not derange their behavior.
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D002110:Caffeine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004924:Escape Reaction / Q000187:drug effects*; D010069:Oxadiazoles / Q000494:pharmacology*; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D013558:Sydnones / Q000494:pharmacology*
D010069:Oxadiazoles; D011619:Psychotropic Drugs; D013558:Sydnones; D002110:Caffeine; D000661:Amphetamine; C009257:sidnocarb
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