title: Lactulose in vincristine-induced constipation.
abstract: Constipation which is resistant to the usual range of laxatives is a troublesome undesirable effect of vincristine. Lactulose in doses up to 25 ml thrice daily proved to be a simple and effective treatment in six patients with refractory vincristine-induced constipation, and a successful prophylactic in two other patients. Palatable, and without any serious undesirable effects, lactulose can improve the quality of life for patients with a malignant tumour which is responsive to vincristine.
mesh_terms: D000328:Adult; D000368:Aged; D003248:Constipation / Q000139:chemically induced / Q000188:drug therapy*; D004187:Disaccharides / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007792:Lactulose / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D014750:Vincristine / Q000009:adverse effects*
chemical_list: D004187:Disaccharides; D007792:Lactulose; D014750:Vincristine