Pharmacological study of the activity of a group of piperizine esters and changes in action relative to their chemical structure.
A group of original symmetrical and asymmetrical piperazine compounds containing ester function have been synthesized and pharmacologically characterized. All compounds are pharmacologically active. Some relationships between their chemical structure and biological activity are discussed. Analgesic and coronary dilatory and especially spasmolytic effects are marked for all asymmetrical esters. A number of the compounds are interesting for further investigations relative to their possible application in medical practice.
D000818:Animals; D002415:Cats; D055598:Chemical Phenomena; D002621:Chemistry; D004347:Drug Interactions; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010879:Piperazines / Q000494:pharmacology* / Q000633:toxicity; D011817:Rabbits; D051381:Rats; D013329:Structure-Activity Relationship
D010879:Piperazines