title: [Polyfunctional role of the alveolar brush cells in the rat lung].
abstract: By means of scanning and transmission electron microscopy it was demonstrated that the number of vacuoles located in the apical part of cytoplasm in alveolar brush cells of the regenerating rat lung increases, hyperplasia of Golgi-complex takes place and the activation of the protein-synthetising apparatus is evident. The immature surfactant material (osmiophilic lamellar bodies) and secretory dense core vesicles were found in the cytoplasm of alveolar brush cells. Intramuscular injections of colchicin to rats (0.1 mg/100 g body weight) 6 times during 24 hours before decapitation does not influence the number, topography and structure of microfibrilla bundles contained in a sufficient amount by alveolar brush cells. At the same time a part of microvilli of alveolar brush cells undergoes destruction and resorption under the action of colchicin. The data on ultrastructural organization of alveolar brush cells show that they are able to fulfill several functions: absorptive, contractile and secretory.
mesh_terms: D000042:Absorption; D000818:Animals; D002462:Cell Membrane / Q000502:physiology*; D006056:Golgi Apparatus / Q000502:physiology*; D008854:Microscopy, Electron; D008871:Microvilli / Q000502:physiology*; D009940:Organoids / Q000502:physiology*; D011650:Pulmonary Alveoli / Q000648:ultrastructure*; D011663:Pulmonary Surfactants / Q000378:metabolism; D051381:Rats; D014617:Vacuoles / Q000502:physiology*
chemical_list: D011663:Pulmonary Surfactants
vernacular_title: O polifunktsional'nom znachenii shchetochnykh al'veolotsitov ("brush-cells") legkogo krysy.