[Inhibition of histamine-sensitive adenylate cyclase system of human gastric mucosa by cimetidine (author's transl)].
Human gastric mucosa contains a histamin-sensitive adenylate cyclase system. The activation of this enzyme system by histamine is competititively inhibited by the H2-receptor blocking agent cimetidine. Our results underscore the rational basis for the use 0f H2-receptor antagonists in the therapy of peptic ulcer.
D000067956:Adenylyl Cyclase Inhibitors; D002927:Cimetidine / Q000494:pharmacology*; D004789:Enzyme Activation; D005753:Gastric Mucosa / Q000187:drug effects*; D006146:Guanidines / Q000494:pharmacology*; D006632:Histamine; D006801:Humans; D010437:Peptic Ulcer / Q000628:therapy
D000067956:Adenylyl Cyclase Inhibitors; D006146:Guanidines; D002927:Cimetidine; D006632:Histamine
Hemmbarkeit der Histamin-stimulierbaren adenylatzyklase der menschlichen Magenschleimhaut durch Cimetidin.