Effects of procainamide and chloramphenicol on acute vasospasm.
The basilar artery of the dog was exposed through the clivus and made spastic by puncture or by topical application of 5% barium chloride. Injections of procainamide or chloramphenicol into the vertebral artery or into a peripheral vein had no discernable effect on the acute vasospasm. Topical application of 0.1% to 10% concentrations of either of these drugs effected definite vasodilation, with the extent and rapidity of vasodilation increasing with increasing concentrations. Lesser concentrations were ineffective.
D000208:Acute Disease; D000287:Administration, Topical; D000818:Animals; D001488:Basilar Artery / Q000187:drug effects*; D002701:Chloramphenicol / Q000008:administration & dosage / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D007275:Injections, Intravenous; D002546:Ischemic Attack, Transient / Q000188:drug therapy*; D011342:Procainamide / Q000008:administration & dosage / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000627:therapeutic use
D014665:Vasodilator Agents; D002701:Chloramphenicol; D011342:Procainamide