Problems in the use of live influenza virus vaccines in patients with chronic bronchopulmonary disease.
A brief review is presented of the problems existing in the organisation and execution of clinical trials of live attenuated influenza vaccine in patients with chronic pulmonary disease. Such trials must be designed to determine the safety of the procedure as well as its immunological effectiveness.
D000368:Aged; D000914:Antibodies, Viral; D001982:Bronchial Diseases; D002908:Chronic Disease; D006801:Humans; D007252:Influenza Vaccines / Q000009:adverse effects*; D008173:Lung Diseases, Obstructive; D008176:Lung Volume Measurements; D009975:Orthomyxoviridae / Q000276:immunology; D012107:Research Design; D006113:United Kingdom; D014613:Vaccines, Attenuated / Q000009:adverse effects*
D000914:Antibodies, Viral; D007252:Influenza Vaccines; D014613:Vaccines, Attenuated