3-Trifluoromethyl-alpha-ethylbenzhydrol (RGH-3332). Liver enzyme induction and D-glucaric acid excretion.
The enzyme inducing effect of 3-trifluoromethyl-alpha-ethylbenzhydrol (RGH-3332, Zixoryn) has been studied in man by means of determining urinary D-glucaric acid output. RGH-3332 was given for ten days, 300 mg/day to 13, 600 mg/day to 11 and 900 mg/day to 11 patients orally. A significant increase of glucaric acid excretion was found in all three groups confirming the enzyme inducing effect of RGH-3332. A tendency to dose-effect relationship was observed. No signs of adverse drug effects were found by laboratory tests. Minor gastrointestinal side effects were observed in two cases of 35 subjects.
D001559:Benzhydryl Compounds / Q000494:pharmacology*; D004790:Enzyme Induction / Q000187:drug effects*; D005937:Glucaric Acid / Q000652:urine*; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D013400:Sugar Acids / Q000652:urine*
D001559:Benzhydryl Compounds; D013400:Sugar Acids; D005937:Glucaric Acid