Terbutaline preventing permeability effects of histamine in the lung.
In unanaesthetized guinea-pigs the effect of terbutaline on histamine-induced increase in lung weight was studied. Terbutaline 0.1 mg/kg and 0.3 mg/kg was given subcutaneously 5 min. before exposure during 60 min. to a histamine aerosol. Terbutaline markedly prevented the histamine-induced increase in lung weight. This effect is discussed in relation to the mechanism of action of mediator-induced increase in vascular permeability.
D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects; D005260:Female; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology*; D008168:Lung / Q000187:drug effects*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011654:Pulmonary Edema / Q000139:chemically induced; D013726:Terbutaline / Q000494:pharmacology*
D006632:Histamine; D013726:Terbutaline