Leukocyte migration test for the study of immune reactivity in cases of Graves disease associated with infiltrative ophthalmopathy.
The leukocyte migration test was carried out in 26 untreated cases of Graves disease, using crude thyroid extract, human eye muscle antigen and actomyosin as antigens. A significant reduction in the spontaneous (antigen-free) migration values was demonstrable in the cases of Graves disease, compared with the controls. The migration inhibition test gave positive results with the thyroid antigen in the hyperthyroid cases, in opposition to euthyroid ophthalmopathy, where it was found negative. The results were positive with retrobulbar muscle antigen in hyperthyroid and euthyroid infiltrative ophthalmopathy. In advanced cases of infiltrative ophthalmopathy, the results were positive with actomyosin as well.
D000205:Actomyosin / Q000276:immunology; D000328:Adult; D001324:Autoantigens / Q000032:analysis; D002464:Cell Migration Inhibition; D005128:Eye Diseases / Q000276:immunology; D005260:Female; D006111:Graves Disease / Q000276:immunology*; D006801:Humans; D006980:Hyperthyroidism / Q000276:immunology; D007962:Leukocytes / Q000276:immunology*; D008297:Male; D009801:Oculomotor Muscles / Q000276:immunology; D013954:Thyroglobulin / Q000032:analysis; D013961:Thyroid Gland / Q000276:immunology; D014020:Tissue Extracts
D001324:Autoantigens; D014020:Tissue Extracts; D013954:Thyroglobulin; D000205:Actomyosin