Modification of the effects of LSD-25, d-amphetamine and tryptamine on electrically evoked responses in the visual system by methiothepin and octoclothepin.
LSD-25 (32 microgram/kg), d-amphetamine (3.2 mg/kg), and tryptamine (320 to 3200 microgram/kg) given intravenously depressed the response recorded in the visual cortex to electrical stimulation of the optic chiasm of the chloralose anesthetized cat. Relatively large doses of 1 mg/kg of the dibenzothiepin derivatives, methiothepin and octoclothepin, antagonized the depressant effects of both LSD-25 and tryptamine to a greater degree than d-amphetamine.
D000818:Animals; D001921:Brain / Q000187:drug effects*; D002415:Cats; D003913:Dextroamphetamine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D003988:Dibenzothiepins / Q000494:pharmacology*; D004558:Electric Stimulation; D004569:Electroencephalography; D005071:Evoked Potentials / Q000187:drug effects; D008238:Lysergic Acid Diethylamide / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D008719:Methiothepin / Q000494:pharmacology*; D013997:Time Factors; D014363:Tryptamines / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D014785:Vision, Ocular / Q000502:physiology*
D003988:Dibenzothiepins; D014363:Tryptamines; D008719:Methiothepin; D008238:Lysergic Acid Diethylamide; D003913:Dextroamphetamine