title: [Ultrastructural changes in the liver in hepatocerebral dystrophy].
abstract: The authors studied the character of subcellular changes in the liver of 15 patients with hepato-cerebral dystrophy and compared them with 5 patients with hepatocirrhosis of a non-hereditary etiology. The mitochondrias suffer most severily from cell organella. Their pathology is more characterized by changes connected with the increase of electronic density and to a lesser degree by swellings. The correlation between the occurrence of electronic dense mitochondrias and the increased hepatocytelipid infiltration is marked. The ultrastructural study has confirmed a preventive role of the lipofuscin complex with cuprum. The main reason of the development of hepacirrhosis in hepato-cerebral dystrophy is the accumulation of cuprum nonutilized by pathogenetical mechanisms--lesion of mitochondrias, tissue hypoxia, necrosis of hepatocytes. The capability of neutralization and withdrawal of cuprum can determine the severity and rapidity of the development of the disease.
mesh_terms: D003300:Copper / Q000378:metabolism; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D006527:Hepatolenticular Degeneration / Q000378:metabolism / Q000473:pathology*; D006651:Histocytochemistry; D006801:Humans; D007728:Kupffer Cells / Q000648:ultrastructure; D008062:Lipofuscin / Q000378:metabolism; D008099:Liver / Q000378:metabolism / Q000648:ultrastructure*; D008112:Liver Glycogen / Q000378:metabolism; D008247:Lysosomes / Q000378:metabolism / Q000648:ultrastructure; D008854:Microscopy, Electron; D008930:Mitochondria, Liver / Q000648:ultrastructure; D009336:Necrosis
chemical_list: D008062:Lipofuscin; D008112:Liver Glycogen; D003300:Copper
vernacular_title: Ul'trastrukturnye izmeneniia pecheni pri gepatotserebral'noĭ distrofii.