title: Degenerative disk disease of the lumbar spine: immunological implications.
abstract: The evidence for an autoimmune mechanism in degenerative disk disease is derived from the presence of a cellular reaction using both the leukocyte-migration inhibition test as well as the lymphocyte transformation test. The associated inflammatory reaction is the basis of the clinical syndrome and the chronicity of sign and symptoms.
mesh_terms: D000818:Animals; D000917:Antibody Formation; D001327:Autoimmune Diseases; D002464:Cell Migration Inhibition; D006801:Humans; D007111:Immunity, Cellular; D007403:Intervertebral Disc / Q000276:immunology*; D007962:Leukocytes / Q000276:immunology; D008213:Lymphocyte Activation; D013122:Spinal Diseases / Q000276:immunology*