Multifocal pontine lesions in cancer patients treated with chemotherapy and CNS radiotherapy.
Multifocal pontine lesions were found at postmortem examination in four patients with various types of malignancy. The patients had undergone extensive evaluation and treatment with multiple chemotherapy regimens as well as radiotherapy to the central nervous system. The histologic character and striking anatomic distribution of the pontine lesions are described and their possible pathogenesis discussed.
D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001927:Brain Diseases / Q000209:etiology* / Q000473:pathology; D001943:Breast Neoplasms / Q000628:therapy; D002528:Cerebellar Neoplasms / Q000628:therapy; D002648:Child; D005260:Female; D005910:Glioma / Q000628:therapy; D006801:Humans; D008223:Lymphoma / Q000628:therapy; D008228:Lymphoma, Non-Hodgkin / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications* / Q000628:therapy; D011149:Pons; D011832:Radiation Injuries / Q000209:etiology* / Q000473:pathology
D000970:Antineoplastic Agents