Mouse tumour tests for quality control of C. parvum preparations.
Description of two mouse tumor tests selected to control the quality of C. parvum pilot productions: transplanted Ehrlich's ascitic tumor in inbred Swiss mice and transplanted YC8 ascitic tumor in isogenic Balb/c mice. The results obtained during three years of control are analyzed, particularly accuracy, long range adequacy and reproducibility of tumor challenges and C, parvum stimulations. The effects of some parameters of the tumor tests, e.g. dose-responses, treatment schedules, tumor-host relationships and standard preparations are discussed.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D011425:Propionibacterium acnes / Q000276:immunology; D011786:Quality Control