Behaviour of murine lymphosarcoma cells during prolonged cultivation in vivo.
Transplantable strain of murine lymphosarcoma growing as a free suspension in the peritoneal cavity of isologous hosts was isolated after fractionated irradiation of C57BL mice. A 14-year cultivation led to changes in its properties; the mean survival time of the hosts was shortened, the modal number of chromosomes changed from 41--42 to 39 and their radioresistance increased slightly. Strain specificity remained unchanged.
D000818:Animals; D002478:Cells, Cultured; D005260:Female; D007621:Karyotyping; D008228:Lymphoma, Non-Hodgkin / Q000401:mortality / Q000473:pathology* / Q000648:ultrastructure; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D009381:Neoplasms, Radiation-Induced / Q000401:mortality / Q000648:ultrastructure; D011836:Radiation Tolerance; D012513:Sarcoma, Experimental / Q000473:pathology; D013160:Splenic Neoplasms / Q000401:mortality / Q000648:ultrastructure; D014184:Transplantation, Homologous