Toxic effects of 8-methoxypsoralen on lymphocyte division.
Cultured human leucocytes have been used to examine the toxicity and phototoxicity of 8-methoxy psoralen (8-MOP). It has been shown that 8-MOP depresses cell turnover at concentrations of 10(-10) M or above. In black light (UVA), 8-MOP inhibition begins at concentrations of 10(-14) M. Patients treated for psoriasis with 8-MOP show concentrations of 10(-6)-10(-7) M. The inhibition of cell turnover observed with the present technique is at this concentration 40% for 8-MOP alone and 70% for 8-MOP and black light. These results can be related to the micronuclei and chromosome abnormalities seen in dividing cells.
D002455:Cell Division / Q000187:drug effects* / Q000528:radiation effects; D002478:Cells, Cultured; D006801:Humans; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000187:drug effects* / Q000528:radiation effects; D008730:Methoxsalen / Q000009:adverse effects* / Q000627:therapeutic use; D011565:Psoriasis / Q000188:drug therapy; D014466:Ultraviolet Rays
D008730:Methoxsalen