Pharmacodynamic study of a pyrophtalone: [methyl-2 (piperidino-2 ethyl-1)-1 dihydro 1-4 pyridylidene-4 yl]-2 indanedione 1-3. I. Anti-inflammatory activity.
The anti-inflammatory activity of a pyrophtalone [methyl-2 (piperidino-2 ethyl-1)-1 dihydro 1-4 pyridylidene-4 yl]-2 indanedione 1-3, has been demonstrated with different methods (carrageenan-induced edema of rat's paw, granuloma formation, adjuvant-induced arthritis). The anti-inflammatory potency is lower but sometimes comparable to that of phenylbutazone. Moreover, the acute toxicity and the ulcerogenic effect of the pyropthalone derivative are clearly less marked.
D000818:Animals; D000893:Anti-Inflammatory Agents; D001169:Arthritis, Experimental / Q000503:physiopathology; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000503:physiopathology; D006099:Granuloma / Q000503:physiopathology; D007189:Indans / Q000009:adverse effects / Q000494:pharmacology* / Q000633:toxicity; D007192:Indenes / Q000494:pharmacology*; D007928:Lethal Dose 50; D008297:Male; D011725:Pyridines / Q000009:adverse effects / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced
D000893:Anti-Inflammatory Agents; D007189:Indans; D007192:Indenes; D011725:Pyridines; D002351:Carrageenan