Serum antibodies before and after immunisation in haemodialysed children.
Serum antibodies (AB) have been measured before and after vaccination in haemodialysed children. The main finding was a normal increase in AB titres following adsorbed vaccines (diphtheria, tetanus, pertussis and poliomyelitis) demonstrating a normal humoral immune ability. By contrast, a poor response to live attenuated viruses (poliomyelitis and measles) was observed. Two additional findings were an inhibitor effect of tetanus toxoid in mice by uraemic serum, and a constant negative Schick test indicative of suppressed non-specific skin reactivity.
D000293:Adolescent; D000907:Antibodies, Bacterial / Q000032:analysis*; D000914:Antibodies, Viral / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D004165:Diphtheria / Q000276:immunology; D006801:Humans; D008457:Measles / Q000276:immunology; D011051:Poliomyelitis / Q000276:immunology; D006435:Renal Dialysis; D013742:Tetanus / Q000276:immunology; D014511:Uremia / Q000276:immunology* / Q000628:therapy; D014611:Vaccination; D014917:Whooping Cough / Q000276:immunology
D000907:Antibodies, Bacterial; D000914:Antibodies, Viral