[Dose-effect relations. Doubleblind study on two different doses of pimozide (author's transl)].
Two identical groups of schizophrenic patients were treated for 28 days randomized with 3 and 8 mg of pimozide. In the antipsychotic efficacy no difference could be seen. Difference was in side effects: The 8-mg group had three times more extrapyramidal signs, mostly akathisia and agitation, and needed seven times more minor tranquilizer than the 3-mg group. Severe agitation as a psychotic symptom was equal in both groups. Preference therefore is given to the smaller dosage.
D000328:Adult; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D006801:Humans; D008875:Middle Aged; D010868:Pimozide / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D012559:Schizophrenia / Q000188:drug therapy*; D012565:Schizophrenic Psychology
D010868:Pimozide
Beziehungen zwischen Dosishöhe und Behandlungsergebnis. Doppelbinduntersuchung mit Pimozid in zwei Dosierungen.