title: Effect of the expulsion phase of Trichinella spiralis on Hymenolepis diminuta infection in mice.
abstract: The rapid elimination of the intestinal phase of Trichinella spiralis in NIH mice is associated with progressive inflammation of the intestinal tract. The non-specific effects of this inflammation were studied in mice concurrently infected with an unrelated parasite, Hymenolepis diminuta, which does not stimulate a visible inflammatory response but is also immunologically rejected by this strain of mice. It was demonstrated that the rejection phase of T. spiralis infection had a marked effect upon the growth and survival of H. diminuta. The cestode either failed to establish or to grow; if the worms were already strobilate when inflammation developed then destrobilation occurred. There was no cross-immunity between the parasites, nor was the interaction a direct consequence of inter-specific competition.
mesh_terms: D000818:Animals; D003348:Cortisone / Q000627:therapeutic use; D006925:Hymenolepiasis / Q000150:complications / Q000276:immunology*; D006926:Hymenolepis / Q000276:immunology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013997:Time Factors; D014234:Trichinella / Q000276:immunology; D014235:Trichinellosis / Q000150:complications / Q000276:immunology*
chemical_list: D003348:Cortisone