Febantel, a new broad-spectrum anthelminthic.
N-(2-[2,3-Bis-(methoxycarbonyl)-guanidino]-5-(phenylthio)-phenyl)-2-methoxyacetamide (febantel, Rintal) is a new compound which is highly active against various species of nematodes and cestodes in mice, rats, dogs, sheep and cattle. In sheep and cattle a single oral dose of 5 mg/kg resulted in an almost complete elimination of larval and adult intestinal nematodes as well as Dictyocaulus. The compound was well tolerated by all animals tested.
D000083:Acetanilides / Q000627:therapeutic use / Q000633:toxicity; D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use* / Q000633:toxicity; D055598:Chemical Phenomena; D002621:Chemistry; D004285:Dogs; D006146:Guanidines / Q000627:therapeutic use* / Q000633:toxicity; D006373:Helminthiasis / Q000188:drug therapy* / Q000469:parasitology; D006374:Helminthiasis, Animal; D007928:Lethal Dose 50; D051379:Mice; D011817:Rabbits; D051381:Rats; D012756:Sheep
D000083:Acetanilides; D000871:Anthelmintics; D006146:Guanidines