title: Amidantel, a potent anthelminthic from a new chemical class.
abstract: N-(4-[(1-(Dimethylamino)-ethylidene)-amino]-phenyl)-2 methoxyacetamide hydrochloride (amidantel, BAY d 8815) is a new aminophenylamidine with an interesting anthelminthic spectrum. In rodents the compound is active against nematodes, filariae and cestodes. Of special interest is the high efficacy in dogs against hookworms and large roundworms. Amidantel was well tolerated by all animals tested and did not show teratogenic effects.
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D002415:Cats; D055598:Chemical Phenomena; D002621:Chemistry; D004285:Dogs; D006373:Helminthiasis / Q000188:drug therapy; D007928:Lethal Dose 50; D051379:Mice; D010655:Phenylenediamines / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D011817:Rabbits; D051381:Rats
chemical_list: D000871:Anthelmintics; D010655:Phenylenediamines