Tallysomycin, a new antitumor antibiotic complex related to bleomycin. I. Production, isolation and properties.
The unusual actinomycetes strain No. E465-94 produced a complex of new glycopeptide antibiotics tallysomycin, which was separated by CM-Sephadex chromatography into two major components, A (C68H107N21O27S2) and B (C62H95N19O26S2). They were isolated first in a copper-chelated form and showed physico-chemical properties similar to those of the bleomycin-group of antibiotics. Tallysomycin exhibited broad antibacterial and antifungal activity, and was highly active in vivo against bacterial infections in mice. Tallysomycins A and B demonstrated potent activity in the prophage induction of lysogenic bacteria.
D000191:Actinomycetaceae / Q000378:metabolism; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology; D000935:Antifungal Agents; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003090:Coliphages / Q000187:drug effects; D005285:Fermentation; D007928:Lethal Dose 50; D007942:Leukemia, Experimental / Q000503:physiopathology; D051379:Mice
D000903:Antibiotics, Antineoplastic; D000935:Antifungal Agents