Biochemical analysis of a lithopedion.
Lithopedions are very rare; the medical literature mentions 330 cases. In the present case, a calcified lithopedion was found in the abdominal cavity of a 69-year-old woman who had died of unrelated causes. In general, the different organs of the lithopedion were easily distinguishable macroscopically. Microscopic examination detected reasonably well preserved structure only in skeletal muscle. Dry weight studies showed a definite dehydration (mummification) had taken place. Chemical analysis revealed a shell consisting mostly of inorganic constituents. Quantitative inorganic analysis of tissues was done and results compared to normal tissues. These results showed significant decrease of K and Cl, significant increase in Mg, P, Na and enormous increase in Ca. These data are compatible with the histologically observed calcification of the tissues. Under proper conditions, presumably dormant enzymes were reactivated in brain, liver, and muscle, although the total activity was low. Discernible LDH isoenzymes were found in liver and muscle. Discernible CK isoenzymes were found in brain and muscle.
D000368:Aged; D000818:Animals; D001921:Brain / Q000201:enzymology; D002114:Calcinosis / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D002712:Chlorides / Q000378:metabolism; D003402:Creatine Kinase / Q000378:metabolism; D004528:Egg Shell / Q000032:analysis; D005260:Female; D005333:Fetus / Q000378:metabolism*; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008099:Liver / Q000201:enzymology; D008274:Magnesium / Q000378:metabolism; D009132:Muscles / Q000201:enzymology; D010758:Phosphorus / Q000378:metabolism; D011188:Potassium / Q000378:metabolism; D011247:Pregnancy; D012964:Sodium / Q000378:metabolism
D002712:Chlorides; D007527:Isoenzymes; D010758:Phosphorus; D012964:Sodium; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase; D008274:Magnesium; D011188:Potassium; D002118:Calcium