title: Conjunctival bleeding in Osler's disease with associated platelet dysfunction. A case report.
abstract: A patient with Osler's disease (hereditary haemorrhagic telangiectasia) was admitted to hospital because of obstinate, profuse conjuctival bleeding occurring without any known preceding rrauma. Extensive examination of the haemostatic mechanism revealed an impaired platelet function reflected in defective platelet aggregation by ADP, collagen adrenalin and defective clot retraction. This platelet dysfunction, whose association with conjunctival telangiectasia was hitherto unknown, impaired the patient's already deficient primary haemostasis following the vascular anomaly and apparently contributed to the severity of the bleeding which could only be checked surgically. The findings seem to warrant investigation of the platelet function in patients with Osler's disease. In the event of platelet dysfunction drugs, such as acetylsalicylic acid (aspirin), indomethacin, dextrans as well as transfusions with bank blood are contraindicated.
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology; D000368:Aged; D001791:Blood Platelet Disorders / Q000209:etiology*; D003018:Clot Retraction; D003094:Collagen / Q000494:pharmacology; D003228:Conjunctiva / Q000098:blood supply*; D004837:Epinephrine / Q000494:pharmacology; D005128:Eye Diseases / Q000209:etiology; D005260:Female; D006470:Hemorrhage / Q000209:etiology*; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects; D013683:Telangiectasia, Hereditary Hemorrhagic / Q000097:blood / Q000150:complications*
chemical_list: D000244:Adenosine Diphosphate; D003094:Collagen; D004837:Epinephrine