Uridine enhances the chemotherapeutic action of the 4'-demethylepipodophyllotoxin-thenylidene-glucoside (VM 26)-cyclophosphamide combination on i.m. implanted Ehrlich carcinoma.
The chemotherapeutic effectiveness of the simultaneously used combination of 4'-demethylepipodophyllotoxin-thenylidene-glucoside (VM 26) and cyclophosphamide was significantly enhanced by uridine in i.m. implanted Ehrlich carcinoma without increasing toxicity when uridine was applied sequentially at an interval of 20 h.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy*; D003520:Cyclophosphamide / Q000627:therapeutic use*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D051379:Mice; D009368:Neoplasm Transplantation; D011034:Podophyllotoxin / Q000031:analogs & derivatives*; D013713:Teniposide / Q000627:therapeutic use*; D014184:Transplantation, Homologous; D014529:Uridine / Q000627:therapeutic use*
D003520:Cyclophosphamide; D013713:Teniposide; D011034:Podophyllotoxin; D014529:Uridine