[The induction of seizures in "Papio papio" following allylglycine alone or in combination with intermittent photic stimulation (author's transl)].
Allylglycine, an inhibitor of GABA synthesis, produces increased sensitivity to photic stimulation and in convulsant doses spontaneous seizures arising occipitally in the baboon (Horton and Meldrum, 1973). In this study, convulsant doses of allylglycine induced either sharp wave and polyspike frontorolandic discharges (FR) or critical posterior discharges which then reinforce the fronto-rolandic spikes. A seizure may then arise from the fronto-rolandic region and secondarily spread to the rest of the cerebral cortex. Intermittent photic stimulation produces a reinforcement of the fronto-rolandic sharp waves and can also induce self-maintaining mechanisms similar to those just described. In this situation, however, and with the animals paralysed with Flaxedil no seizures arising occipitally have been observed. The role of the occipital cortex as the sensory visual and somatic afferent in photosensitive epilepsy in the baboon is discussed in the light of these results.
D000498:Allyl Compounds / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D005998:Glycine / Q000031:analogs & derivatives*; D010215:Papio; D010775:Photic Stimulation; D012640:Seizures / Q000139:chemically induced / Q000209:etiology* / Q000503:physiopathology
D000498:Allyl Compounds; D005998:Glycine
Les crises induites-ou non-par la stimulation lumineuse intermittente chez le "Papio papio" après injection d'allylglycine.