Changes in volemia and natremia and onset of sodium appetite in sodium depleted rats.
Rats depleted of sodium by the IP injection of 10% b.w. of isotonic glucose for 30 min, developed a specific sodium appetite. The blood volume decreased 16% of the control value immediately after the treatment, returning to normal levels 2 to 4 hr later. The plasma sodium concentration showed a sudden and significant decrease, returning to control value 10-12 hr after the dialysis. In contrast, the sodium appetite became evident 10-12 hr after dialysis and reached the highest volume of ingestion at the sixteenth hr when both volemia and natremia had returned to normal. Since the appearance of the sodium appetite was not initiated during the state of hypovolemia and hyponatremia, the results show that the decrease in plasma volume and sodium concentration of the intravascular fluid that occurs after acute sodium depletion by IPD does not initiate an immediate onset of the sodium appetite.
D000818:Animals; D001810:Blood Volume; D003956:Dialysis; D004326:Drinking; D005518:Food Preferences; D006400:Hematocrit; D008297:Male; D051381:Rats; D012964:Sodium / Q000097:blood / Q000172:deficiency / Q000378:metabolism*; D013997:Time Factors
D012964:Sodium