Exocrine secretion of the pancreas and enzymes in the lymph after administration of a combination of courmarin and rutin sulphate.
The effect of Venalot, a combination of coumarin and rutin sulphate, on stimulated exocrine secretion of the pancreas and on changes of pancreatic enzymes in thoracic duct lymph was studied in 10 subjects with normal function of the pancreas. Venalot has no direct effect on the exocrine function of the pancreas. Following administration of the compound, the amylase and lipase activity in thoracic duct lymph increases temporarily, probably as a consequence of outflow from the interstitial liquid of the pancreas.
D000328:Adult; D000681:Amylases / Q000378:metabolism; D001639:Bicarbonates / Q000378:metabolism; D003374:Coumarins / Q000494:pharmacology*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D006896:Hydroxyethylrutoside / Q000031:analogs & derivatives* / Q000494:pharmacology; D008049:Lipase / Q000378:metabolism; D008196:Lymph / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D012431:Rutin / Q000031:analogs & derivatives*
D001639:Bicarbonates; D003374:Coumarins; D004338:Drug Combinations; D006896:Hydroxyethylrutoside; D012431:Rutin; D008049:Lipase; D000681:Amylases