Synthesis, pharmacologic and toxicologic study of carbonic and carbamic acid esters.
The results of the pharmacologic study of some synthesized derivatives of carbamic and carbonic acids show that the compounds are biologically active. They are less toxic than imipramine, and exert a marked excitation effect on the central nervous system. Some of the compounds (including PS-1, P-8-Y and PS-4) possess greater antidepressive action than imipramine.
D000818:Animals; D002219:Carbamates / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D002254:Carbonates / Q000138:chemical synthesis*; D002255:Carbonic Acid / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D055598:Chemical Phenomena; D002621:Chemistry; D004952:Esters; D008297:Male; D051379:Mice; D051381:Rats; D012110:Reserpine / Q000037:antagonists & inhibitors
D002219:Carbamates; D002254:Carbonates; D004952:Esters; D002255:Carbonic Acid; D012110:Reserpine