title: Morphological changes in rat skeletal muscle following reinnervation.
abstract: Morphological changes appearing in the course of muscle regeneration after reinnervation of denervated M. soleus (slow) and M. tibialis anterior (fast) rat skeletal muscle were investigated. It was found that pathological changes typical for denervation atrophy (seen on the 10th day after crushing the sciatic nerve) and symptoms of regeneration (beginning about the 15th day) were much more pronounced in the soleus than in the tibialis muscle. Some stages of regeneration in the soleus muscle could be distinguished. The contractile material destructions were the first pathological changes that disappeared after the beginning of regeneration. In the second stage other denervation changes disappeared and intensive regeneration of muscle fibres was observed. In the next stage regeneration slowed down, and the reduction of the excess of muscle nuclei was visible. Four months after crushing the nerve, regeneration proceeded to completion with only some traces of the passed processes: in the soleus muscle, chains of sarcolemmal nuclei, satellite cells and newly formed muscle fibres were more often seen than in contralateral muscle; in the tibialis, collagen depots were present around the vessels and between muscle fascicles.
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000648:ultrastructure; D003094:Collagen; D003239:Connective Tissue Cells; D003714:Denervation; D005260:Female; D008297:Male; D009132:Muscles / Q000294:innervation / Q000502:physiology* / Q000648:ultrastructure; D009409:Nerve Crush; D009416:Nerve Regeneration; D010587:Phagocytosis; D051381:Rats; D012038:Regeneration
chemical_list: D003094:Collagen