Generalized microsporum audoninii infection and depressed cellular immunity associated with a missing plasma factor required for lymphocyte blastogenesis.
Described herein is a 15 year old girl with a generalized, possibly systemic Microsporum audouinni infectin associated with anergy and defective lymphocyte transformation as a consequence of a deficiency of an uncharacterized plasma factor. Intravenous administration of plasma, obtained from normal donors, has produced consistent although incomplete clinical improvement. Defective lymphocyte transformation to M. audiouinii antigen cultured in autologous plasma became normal after infusions of normal plasma were instituted. Systemic administrations of griseofulvin, clotrimazole and miconazole produced transient and incomplete clinical improvement. Clearing of the cutaneous infection and stabillization of the neurologic status was finally achieved with plasma infusions combined with parenterally administered amphotericin B.
D000293:Adolescent; D000666:Amphotericin B / Q000627:therapeutic use; D000946:Antigens, Fungal; D001921:Brain / Q000000981:diagnostic imaging; D002634:Chemotaxis, Leukocyte; D003881:Dermatomycoses / Q000188:drug therapy / Q000276:immunology*; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D008213:Lymphocyte Activation; D008222:Lymphokines / Q000096:biosynthesis; D008864:Microsporum / Q000254:growth & development / Q000276:immunology*; D011877:Radionuclide Imaging; D012882:Skin Tests; D014165:Transfer Factor
D000946:Antigens, Fungal; D008222:Lymphokines; D014165:Transfer Factor; D000666:Amphotericin B