[Studies on the analysis of nifedipine considering in particular transformation products formed by light exposition (author's transl)].
Under the influence of light (VIS and UV) on thin-layer plates and in liquid solutions, 1,4-dihydro-2,6-dimethyl-4-(0-nitro-phenyl)-pyridine-3,5-carboxylic acid dimethylester (nifedipine, Adalat) is converted to the nitroso compound 4-(2-'nitrosophenyl)-2,6-dimethyl-3,5-dicarbomethoxy-pyridine. The article also describes TLC-, GLC-, UV-, IR- and MS-data of nifedipine, the nitroso and the nitro derivative.
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002849:Chromatography, Gas; D004355:Drug Stability; D008027:Light; D013058:Mass Spectrometry; D009543:Nifedipine / Q000032:analysis* / Q000528:radiation effects; D009603:Nitroso Compounds / Q000032:analysis; D011725:Pyridines / Q000032:analysis*
D009603:Nitroso Compounds; D011725:Pyridines; D009543:Nifedipine
Untersuchungen zur Analytik von Nifedipin unter besonderer Berücksichtigung der bei Lichtexposition entstehenden Umwandlungsprodukte.