title: Central effect of 5,8,11,14-eicosatetraenoic acid (arachidonic acid) on the temperature in the conscious rabbit.
abstract: Hyperthermia induced by arachidonic acid in rabbit was attenuated by phenoxybenzamine, cyproheptadine and indomethacin. The reduction in arachidonic acid hyperthermia, after 6-OH-DA and the failure of PCPA to reduce this rise, indicates the involvement of noradrenaline in arachidonic acid hyperthermia.
mesh_terms: D000818:Animals; D001095:Arachidonic Acids / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D001831:Body Temperature / Q000187:drug effects*; D003533:Cyproheptadine / Q000494:pharmacology; D005334:Fever / Q000139:chemically induced; D006892:Hydroxydopamines / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D010643:Phenoxybenzamine / Q000494:pharmacology; D011817:Rabbits
chemical_list: D001095:Arachidonic Acids; D006892:Hydroxydopamines; D010643:Phenoxybenzamine; D003533:Cyproheptadine; D007213:Indomethacin