Multiple myeloma, IgA cryoglobulinemia and serum hyperviscosity in a dog.
Clinical signs of hyperviscosity syndrome in a 6-year-old dog included listlessness, polydipsia, anorexia, vomiting, and recurrent bleeding from the gums. Fundoscopy showed the typical retinal changes associated with this syndrome. A polymeric IgA cryoglobulin characterized in the dog's serum was later isolated and structurally studied. It was found to contain J chain but no secretory component. The heavy and light chains were covalently bound.
D000818:Animals; D001809:Blood Viscosity; D003450:Cryoglobulins; D004285:Dogs; D004591:Electrophoresis, Polyacrylamide Gel; D007122:Immunoelectrophoresis; D007070:Immunoglobulin A; D008297:Male; D009101:Multiple Myeloma / Q000150:complications* / Q000473:pathology; D010265:Paraproteinemias / Q000150:complications* / Q000473:pathology; D012635:Secretory Component
D003450:Cryoglobulins; D007070:Immunoglobulin A; D012635:Secretory Component