18 month skin painting study of a mercapto-functional silicone oil in mice.
Thrice weekly application of lambda-mercapto-polydimethylsiloxane to the shaven backs of Swiss mice over an 18 month period did not have an obvious effect on weight gain nor did this material produce systemic toxicity. Lung adenomas and lymphosarcomas were observed upon histopathological examination in both untreated and treated group. Other lesions observed were not thought to be treatment related.
D000236:Adenoma / Q000139:chemically induced; D000287:Administration, Topical; D000818:Animals; D004129:Dimethylpolysiloxanes / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D008175:Lung Neoplasms / Q000139:chemically induced; D008228:Lymphoma, Non-Hodgkin / Q000139:chemically induced; D008297:Male; D051379:Mice; D009821:Oils / Q000008:administration & dosage / Q000633:toxicity*; D012828:Silicones / Q000633:toxicity*; D013997:Time Factors
D004129:Dimethylpolysiloxanes; D009821:Oils; D012828:Silicones