Preliminary observations on orgotein treatment of canine cataract.
In 2 clinical studies of canine cataract, mostly bilateral, intraocular injection of orgotein (Palosein: Diagnostic Data) was followed by varying degrees of clearing of lens opacity and return of functional vision in 39 of 56 dogs, most of which were given 1 injection (1.25 mg). First evidence of sight return and lens clearing was observed at 3-14 weeks post-treatment. In 2 dogs, clearing of cataract was followed by recurrence, and repeat treatment in one of these effected improvement. Although these results must be considered preliminary, in part because they relate to clinical cases not susceptible to controlled study, the apparent success rate suggests the feasibility of larger-scale studies under controlled conditions.
D000818:Animals; D002386:Cataract / Q000188:drug therapy / Q000662:veterinary*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D005260:Female; D007267:Injections; D008297:Male; D008667:Metalloproteins / Q000008:administration & dosage / Q000627:therapeutic use*
D008667:Metalloproteins; C005180:orgotein