[Uridine incorporation into the RNA of stimulated lymphocytes with different sets of sex chromosomes].
Phytohemagglutinin (PHA)-induced stimulation of uridine incorporation into RNA was studied with cotton-wool isolated peripheral blood human lymphocytes. The amount of labeling in 24-hour cultures proved to be increased in men and in 45,XO patients, compared to women. With high doses of PHA applied, hyperreactivity of the 45, XO cells was revealed. PHA-activation in normal persons tends to decrease with advancing age. Complex genomic as well as sex hormone effects may be responsible for the differences observed.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002478:Cells, Cultured; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D037102:Lectins / Q000494:pharmacology*; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012313:RNA / Q000096:biosynthesis*; D012737:Sex Factors; D014424:Turner Syndrome / Q000097:blood / Q000378:metabolism*; D014529:Uridine / Q000378:metabolism*
D037102:Lectins; D012313:RNA; D014529:Uridine
Vkliuchenie uridina v RNK stimulirovannykh limfotsitov s razlichnym naborom polovykh khromosom.