[Radioimmuno assay of drugs (author's transl)].
Radioimmuno assays for routine analyses of hormones were developed in clinical laboratories in the early sixties. The importance of this procedure has increased permanently. The method bases upon the reaction of an antigen with an antibody to an antigen-antibody complex. A labelled antigen is used to quantify the formation of the complex. To demonstrate the development of a drug radioimmuno assay nomifensine was used, that has a complex pattern of metabolism. High sensitivity, high specificity, low interference in samples of patients with multiple therapy, simple handling of a great number of samples per person, good interlaboratory reproducibility, and low costs are the advantages of this procedure justifying the relatively high expense for introducing a control area for isotopes.
D000418:Albumins; D000917:Antibody Formation; D000941:Antigens / Q000032:analysis; D006801:Humans; D007457:Iodine Radioisotopes; D009627:Nomifensine / Q000032:analysis; D004364:Pharmaceutical Preparations / Q000032:analysis* / Q000378:metabolism; D011863:Radioimmunoassay
D000418:Albumins; D000941:Antigens; D007457:Iodine Radioisotopes; D004364:Pharmaceutical Preparations; D009627:Nomifensine
Radioimmunologische Bestimmungen von Arzneimitteln.