title: Susceptibility to erythromycin of anaerobes of the genera Bacteroides, Fusobacterium, Sphaerophorus, Veillonella, Clostridium, Corynebacterium, Peptococcus, Peptostreptococcus.
abstract: The minimal inhibitory concentrations (MIC) of erythromycin were determined by broth dilution tests for 313 anaerobic strains, most of which were clinical isolates. All the gram-positive anaerobes tested (84 Peptococcaceae, including 21 Peptostreptococcus anaerobius and 15 Peptococcus variabilis; 65 Corynebacterium acnes and 29 Clostridium strains, including 13 C. perfringens) were sensitive (MIC values 0.012 through 3.12 microgram erythromycin/ml); so were 111 cultures of gram-negative anaerobes (52 Bacteroides fragilis, 12 B. thetaiotaomicron, 7 B. vulgatus, 13 B. oralis, 4 B. melaninogenicus, 10 Sphaerophorus necrophorus, 2 Veillonella sp., 11 members of other species). Erythromycin at concentrations of 6.25 through 200.0 microgram/ml was active against 24 strains (1 B. fragilis, 4 Fusobacterium fusiforme, 9 Sph. freundi, 10 Sph. varius). The present results are compared to the limited number of reports existing with regard to the susceptibility of anaerobes to erythromycin.
mesh_terms: D001439:Bacteroides / Q000187:drug effects*; D003013:Clostridium / Q000187:drug effects*; D003352:Corynebacterium / Q000187:drug effects*; D004917:Erythromycin / Q000494:pharmacology*; D005673:Fusobacterium / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D010460:Peptococcus / Q000187:drug effects*; D010462:Peptostreptococcus / Q000187:drug effects*; D013045:Species Specificity; D014678:Veillonella / Q000187:drug effects*
chemical_list: D004917:Erythromycin