Interaction of indolmycin in the metabolism of tryptophan in rat liver.
When compared with other tryptophan analogues, indolmycin is a potent inhibitor of tryptophan pyrrolase and tryptophan decarboxylase, both enzymes involved in tryptophan catabolism. Otherwise the decarboxylation of 5-hydroxytryptophan is only slightly affected by indolmycin. The indolmycin derivative, 2-methylamino-5-(1-naphthylmethyl)-oxazolidin-4-one (YX-CX 22 XX) demonstrates only a slightly weaker inhibitory effect in the tryptophan-tRNA-ligase system in E. coli but does not show any significant action on the tryptophan metabolism in the eukaryotic system.
D000818:Animals; D004790:Enzyme Induction / Q000187:drug effects; D066298:In Vitro Techniques; D007211:Indoles / Q000378:metabolism / Q000494:pharmacology*; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008750:Methyldopa / Q000494:pharmacology; D008781:Methyltyrosines / Q000494:pharmacology; D051381:Rats; D014366:Tryptophan Oxygenase / Q000378:metabolism; D014369:Tryptophan-tRNA Ligase / Q000037:antagonists & inhibitors
D007211:Indoles; D008781:Methyltyrosines; D008750:Methyldopa; D014366:Tryptophan Oxygenase; D014369:Tryptophan-tRNA Ligase