Effects of repeated applications of two semi-permanent hair dyes to the skin of A and DBAf mice.
Two proprietary semi-permanent hair dyes were tested for carcinogenicity in A and DBAf mice by repeated topical applications in aqueous acetone. Mice of both strains developed lymphoid tumours but experimental differences were marked only in DBAf mice. A number of tumours of the ovary and uterus, and some skin papillomas near the penis, occured in dye-treated but not in control DBAf mice. As many hair-dye constituents are known mutagens, adequate carcinogenicity testing of these substances, and epidemiological study of exposed human populations, are needed for evaluating possible health hazard from hair dyeing.
D000818:Animals; D004396:Coloring Agents / Q000633:toxicity*; D005260:Female; D006197:Hair; D008175:Lung Neoplasms / Q000139:chemically induced; D008223:Lymphoma / Q000139:chemically induced; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008811:Mice, Inbred DBA; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D014565:Urogenital Neoplasms / Q000139:chemically induced
D004396:Coloring Agents