Effect of pancuronium bromide on the adrenergic reactivity of the isolated rat vas deferens.
Pancuronium bromide (10(-7) to 10(-4) M) failed to produce contraction of the isolated rat vas deferens. Also, no contractions were seen when the animals were pretreated with an MAO inhibitor (iproniazid 80 mg/kg, p.o.). On the other hand, pancuronium bromide (10(-6) to 10(-4) M) produced 1.62- to 2.65-fold increases in the sensitivity of the vas deferens to noradrenaline. This rules out an indirect adrenergic effect in this preparation and suggests an inhibitory effect on catecholamine uptake.
D000818:Animals; D007490:Iproniazid / Q000494:pharmacology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D010197:Pancuronium / Q000494:pharmacology*; D051381:Rats; D013564:Sympathetic Nervous System / Q000187:drug effects*; D014649:Vas Deferens / Q000187:drug effects / Q000294:innervation
D007490:Iproniazid; D010197:Pancuronium; D009638:Norepinephrine