title: Chronic double lumen intravenous cannulation of the unrestrained rat.
abstract: Chronic double lumen intravenous cannulation was performed on the rat. The cannulation system consisted of a pulley assembly, protective tube, mounting post, and a double lumen cannula. Using a double lumen expanded catheter, a two-channel connection was made with the rat's vascular system through a single entry into the external jugular vein. The cannulation system permitted free animal movement in a large cage and simultaneous measurement of behavioral and physiologic variables. The procedure minimized stress and provided a simple alternative to other systems using two cannulas.
mesh_terms: D000818:Animals; D000830:Animals, Laboratory; D002404:Catheterization / Q000295:instrumentation / Q000662:veterinary*; D008722:Methods; D051381:Rats