title: [On the development of an oral preparation of meproscillarin (author's transl)].
abstract: Analytical methods of determination, investigations of stability and the behaviour of the substance in artificial gastric and intestinal fluids are the bases for the formulation of an oral preparation of 14-hydroxy-3beta-[4-O-methyl-alpha-L-rhamnopyranosyl)oxy]-14beta-bufa-4,20,22-trienolide (meproscillarin, Clift). The problems of developing a stable form, the maintenance of uniform content and the bioavailability are discussed.
mesh_terms: D000284:Administration, Oral; D001682:Biological Availability; D002301:Cardiac Glycosides / Q000008:administration & dosage* / Q000032:analysis; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003720:Densitometry; D004355:Drug Stability; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet; D013607:Tablets; D013997:Time Factors
chemical_list: D002301:Cardiac Glycosides; D013607:Tablets
vernacular_title: Entwicklung einer oralen Darreichungsform von Meproscillarin.