Effects of substituted 1,2,3-triazoles on adenosine deaminase, guanine deaminase and xanthine oxidase.
The action of some known and new synthesized substituted 1,2,3-triazoles on adenosine deaminase, guanine deaminase and xanthine oxidase was studied. The effect of substituents in 1, 4 and 5 positions was studied and discussed. The presence of a carboxamido group in 4 position seems to be essential in the binding to adenosine deaminase.
D058892:Adenosine Deaminase Inhibitors; D000619:Aminohydrolases / Q000037:antagonists & inhibitors*; D000818:Animals; D001665:Binding Sites; D002417:Cattle; D006148:Guanine Deaminase / Q000037:antagonists & inhibitors*; D066298:In Vitro Techniques; D009700:Nucleoside Deaminases / Q000037:antagonists & inhibitors*; D011817:Rabbits; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors*
D058892:Adenosine Deaminase Inhibitors; D014230:Triazoles; D014969:Xanthine Oxidase; D000619:Aminohydrolases; D009700:Nucleoside Deaminases; D006148:Guanine Deaminase