title: A study on the stability of diphenylindenonesulphonyl derivatives of amino acids to acid hydrolyses.
abstract: The stability of the diphenylindenonesulphonyl (disyl) derivatives of tryptophan, proline, hydroxyproline, histidine, serine, threonine and aspartic acid, as well as of glycine, alanine, alpha-amino butyric acid, phenylalanine, valine, leucine and isoleucine to acid hydrolysis is studied. The results indicate that the disyl derivatives are much more stable in comparison with the corresponding DNP- and DNS-derivatives. Hence, the dysil-chloride method possesses definite advantages over these widely used methods for determination of N-terminal groups, not only because of its higher sensitivity, but also because of the higher stability of the disyl derivatives of amino acids to acid hydrolysis.
mesh_terms: D000596:Amino Acids / Q000032:analysis; D055598:Chemical Phenomena; D002621:Chemistry; D002850:Chromatography, Gel; D004355:Drug Stability; D006868:Hydrolysis; D007192:Indenes / Q000032:analysis; D008722:Methods; D013450:Sulfones / Q000032:analysis
chemical_list: D000596:Amino Acids; D007192:Indenes; D013450:Sulfones