[Effect of short-term microcirculatory disorders on indices of myocardial energy metabolism].
Disturbance of the microcirculation produced by the combined injection of the high molecular weight dextran and vasopressin led as soon as the first minutes (5 min) to the intensification of glycolysis. This was testified to by the reduction of glycogen concentration by 19.4 percent, elevation of the phosphorylase "A" activity by 30-36 percent and of the pyruvic acid by 36.9 percent. The ATP, ADP, AMP, and the KP concentration remained unchanged. The observed glycolysis changes can be regarded as the initial metabolic reactions resulting from hypoxia originating in microcirculation disturbances.
D000244:Adenosine Diphosphate / Q000032:analysis; D000249:Adenosine Monophosphate / Q000032:analysis; D000255:Adenosine Triphosphate / Q000032:analysis; D000818:Animals; D002682:Chinchilla; D003327:Coronary Disease / Q000378:metabolism*; D004734:Energy Metabolism; D006003:Glycogen / Q000032:analysis; D007773:Lactates / Q000032:analysis; D008833:Microcirculation; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism*; D010725:Phosphocreatine / Q000032:analysis; D010758:Phosphorus / Q000032:analysis; D006005:Phosphorylases / Q000378:metabolism; D011773:Pyruvates / Q000032:analysis; D011817:Rabbits
D007773:Lactates; D011773:Pyruvates; D010725:Phosphocreatine; D010758:Phosphorus; D000249:Adenosine Monophosphate; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D006003:Glycogen; D006005:Phosphorylases
Vliianie kratkovremennogo narusheniia mikrotsirkuliatsii na pokazateli énergeticheskogo obmena v miokarde.