title: Chemical and radiochemical stability of the adrenal-scanning agents, 6beta-iodomethyl-19-norcholest-5(10-en-3beta-ol and 19-iodocholest-5-en-3beta-ol.
abstract: The chemical stabilities of the adrenal-scanning agents, 6beta-iodo-methyl-19-norcholest-5(10)-en-3beta-ol (6-iodomethylnorcholesterol) and 19-iodocholest-5-en-3beta-ol (19-iodocholesterol), and several of their derivatives were examined by 13C nuclear magnetic resonance. Neat 6-iodomethylnorcholesterol, sealed in glass under nitrogen and stored at 0 degrees C, remains 98 mole% chemically pure for 3 months. Neat 19-iodocholesterol, stored in the dark at 25 degrees C, remains 98 mole% chemically pure for 3 months. Either 6-iodomethylnorcholesterol-125I or-131I, informulation and stored at 5 degrees C, will remain greater than 97% radiochemically pure for at least 15 days. Labelled 19-iodocholesterol, formulated and stored under the same conditions, shows 20% decomposition after 3 weeks and 40% after 6 weeks.
mesh_terms: D000311:Adrenal Glands / Q000000981:diagnostic imaging*; D002782:Cholestenes / Q000138:chemical synthesis; D004355:Drug Stability; D004356:Drug Storage; D006914:Hydroxysteroids / Q000138:chemical synthesis; D007457:Iodine Radioisotopes; D007553:Isotope Labeling; D009682:Magnetic Resonance Spectroscopy; D009654:Norsteroids / Q000138:chemical synthesis; D011877:Radionuclide Imaging
chemical_list: D002782:Cholestenes; D006914:Hydroxysteroids; D007457:Iodine Radioisotopes; D009654:Norsteroids