[Effect of chloramphenicol on the toxic and therapeutic effect of N-nitrosomethylurea].
The influence of chloramphenical (CAP) on toxic and therapeutic effect of N-nitrosomethyl urea (MNU) in mice of CBA line was studied. It is shown that in injection of lethal doses of MNU--0.08--0.1 mg/g in intact animals CAP reduced LD100 to LD50 and LD50 to LD0. Also CAP increased an average survival of animals with ascites Ehrlich tumor when injected the lethal dose of MNU--0.1 mg/g. Therapeutic effect of MNU in a dose of 0.05--0.075 mg/g in the presence of CAP was not changed and sometimes was even increased. Under discussion is the significance of the obtained results for chemotherapy of malignant tumors in man.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D002701:Chloramphenicol / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D008770:Methylnitrosourea / Q000627:therapeutic use / Q000633:toxicity*; D051379:Mice; D008808:Mice, Inbred CBA; D009607:Nitrosourea Compounds / Q000633:toxicity*; D013997:Time Factors
D009607:Nitrosourea Compounds; D002701:Chloramphenicol; D008770:Methylnitrosourea
Vliianie khloramfenikola na toksicheskiĭ i lechebnyĭ éffekt N-nitrozometilmocheviny.