[Studies on possible interactions of thalidomide and genetic material from chicken embryos (author's transl)].
Tritium labelled thalidomide was applied to chicken embryos of various stages and the distribution of the readioactive label was investigated. No specific binding tendency to components of the cell could be found, especially no affinity to nucleic acids and to the chromosomal proteins (histones and non-histones) could be observed, which had been discussed hypothetically. An influence on DNA replication and transcription rate could also not be detected.
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D002642:Chick Embryo; D002843:Chromatin / Q000378:metabolism; D004247:DNA / Q000378:metabolism*; D004261:DNA Replication / Q000187:drug effects; D003956:Dialysis; D009698:Nucleoproteins / Q000378:metabolism*; D012313:RNA / Q000096:biosynthesis; D013792:Thalidomide / Q000378:metabolism / Q000494:pharmacology*; D013997:Time Factors
D002843:Chromatin; D009698:Nucleoproteins; D013792:Thalidomide; D012313:RNA; D004247:DNA
Untersuchungen zur Frage der Wechselwirkung zwischen Thalidomid und dem genetischen Material aus Hühnerembryonen.