Excretion of salt and water by patients with sickle-cell anaemia: effect of a diuretic and solute diuresis.
1. Patients with sickle-cell anaemia were unable to increase free water reabsorption (TcH2O) in response to intravenous hypertonic sodium chloride solution. 2. Ethacrynic acid caused a brisk natriuresis in patients with sickle-cell anaemia but fractional sodium excretion was lower in these patients. 3. These findings could be explained by abnormal function of the loop of Henle.
D000328:Adult; D000755:Anemia, Sickle Cell / Q000378:metabolism*; D004231:Diuresis / Q000187:drug effects*; D004976:Ethacrynic Acid / Q000494:pharmacology*; D006801:Humans; D009318:Natriuresis / Q000187:drug effects; D012964:Sodium / Q000652:urine; D012965:Sodium Chloride / Q000494:pharmacology*
D012965:Sodium Chloride; D012964:Sodium; D004976:Ethacrynic Acid