Feline interferon response to 2-amino-5-bromo-6-methyl-4-pyrimidinol (U-25,166).
U-25,166 induced high serum interferon levels in cats at concentrations at least 40 times less than the maximum tolerated dose. Although certain cats responded to U-25,166 by consistently producing higher interferon levels than did other cats, this relationship was not observed if the same animals were injected with Newcastle disease virus or polyriboinosinic:polyribocytidylic acid (poly I:C). Using a biweekly treatment regimen, cats remained responsive to interferon induction by U-25,166 over an 18-week period in which 9 doses of the compound were given. Cats given the compound daily, however, soon became hyporesponsive to interferon induction. Interferon was induced in cats given U-25,166 orally as a suspension or in capsules, but circulating interferon levels were low in cats given the drug by subcutaneous injection.
D000284:Administration, Oral; D000818:Animals; D002214:Capsules; D002415:Cats / Q000378:metabolism*; D005260:Female; D007279:Injections, Subcutaneous; D007369:Interferon Inducers / Q000494:pharmacology*; D007372:Interferons / Q000097:blood*; D008297:Male; D009522:Newcastle disease virus / Q000276:immunology; D011070:Poly I-C / Q000494:pharmacology; D011743:Pyrimidines / Q000008:administration & dosage / Q000494:pharmacology*
D002214:Capsules; D007369:Interferon Inducers; D011743:Pyrimidines; C014927:2-amino-5-bromo-6-methyl-4-pyrimidinol; D007372:Interferons; D011070:Poly I-C