title: [Study on the induction of chronical trichophytosis in small experimental animals for screening antimycotic agents. 3rd communication: the effect of cyclophosphamide on experimental trichophytosis in guinea pigs (author's transl)].
abstract: Elevated doses of the cytostatic cyclophosphamide (Endoxan) given daily for 6 weeks, resulted in a prolonged course of experimental trichophytosis in guinea-pigs. From this phenomenon, it may be concluded that the short self-healing course of this disease is due to a rapid triggering of immunoreactions. The fractionated treatment with cyclophosphamide at defined intervals (50 mg/kg initially and 30 mg/kg at 4-day intervals) did not result in any effect.
mesh_terms: D000818:Animals; D003520:Cyclophosphamide / Q000494:pharmacology*; D004195:Disease Models, Animal; D005260:Female; D006168:Guinea Pigs; D007111:Immunity, Cellular / Q000187:drug effects; D008297:Male; D013997:Time Factors; D014005:Tinea / Q000276:immunology / Q000473:pathology / Q000503:physiopathology*
chemical_list: D003520:Cyclophosphamide
vernacular_title: Versuche zur Erzeugung einer chronischen Trichophytie bei kleinen Versuchstieren für die Prüfung von Antimykotika. III. Mitt.: Die Wirkung von Cyclophosphamid auf die experimentelle Meerschweinchen-Trichophytie.