[Damage to the isolated heart due to adrenaline perfused with a saline solution].
Perfusion of the isolated heart with Krebs solution containing 5 and 20 microgram/ml of adrenaline induced cardiocyte micronecrosis. Perfusion with 0.5 microgram/ml of adrenaline induced no micronecrosis. Dispersion analysis showed a statistically significant effect of adrenaline concentrations on the degree of the cardionecrotic effect. The fact of micronecrosis appearance in the isolated heart during its perfusion with saline solution requires revision of the hypothesis on the leading role of blood factor in the realization of the cardionecrotic effect of adrenaline. The appearance of micronecroses with the action of adrenaline in concentrations which activate the mechanism of amines uptake by the heart myocytes speaks in favour of the casual relationship between the accumulation of the biogenic amines by myocytes and the development of their necrosis.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000633:toxicity*; D006331:Heart Diseases / Q000139:chemically induced*; D006651:Histocytochemistry; D008297:Male; D009206:Myocardium / Q000201:enzymology; D009336:Necrosis; D010477:Perfusion; D051381:Rats; D013385:Succinate Dehydrogenase / Q000378:metabolism
D013385:Succinate Dehydrogenase; D004837:Epinephrine
Povrezhdenie izolirovannogo serdtsa adrenalinom v usloviiakh perfuzii ego solevym rastvorom.