Immunoglobulin concentrations in first-degree relatives of epileptic patients with drug-induced IgA deficiency.
Serum immunoglobulins A, G and M were studied in parents and siblings of 16 patients being treated for epilepsy. Five healthy families served as controls. Seven of the patients were low IgA-responders and the rest of the patients had shown normal IgA-levels during treatment. None of the parents and siblings studied showed a serum-IgA deficiency, with the exception of one mother who was being treated for rheumatoid arthritis with naproxen. Low serum concentrations of IgG and IgM were not found. A significantly increased IgM-level was found in first-degree relatives of the low IgA-responders, and the siblings of low 2gA-responders had significantly raised IgA in their sera.
D000293:Adolescent; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D003241:Consanguinity; D004406:Dysgammaglobulinemia / Q000139:chemically induced*; D004827:Epilepsy / Q000188:drug therapy / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis
D000927:Anticonvulsants; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins