A pharmacokinetic model for predicting pesticide residues in fish.
By using the compartmental analysis approach of pharmacokinetics, found useful in describing the kinetics of a foreign compound in a biological system, a rather simple mathematical model was developed to predict, by computer simulation, steady-state pesticide residues in fish from limited pre-steady-state experimental data. Such steady-state data are needed in order to calculate the tendency of the residue to concentrate in fish--the so-called bioconcentration factor. The model was applied to four different carbon-14 labeled biocides at seven concentrations. Considering the simplicity of the model and the fact that residues were measured by the non-specific technique of radioassay, model predicted values were in good agreement with experimental values.
D000818:Animals; D003201:Computers; D005399:Fishes / Q000378:metabolism*; D007700:Kinetics; D008954:Models, Biological; D010573:Pesticide Residues / Q000378:metabolism*; D013997:Time Factors
D010573:Pesticide Residues