K cell activity of normal and chronic lymphocytic leukaemia lymphocytes: association with lymphocytes bearing receptors for human C3b.
Blood lymphocytes of patients with chronic lymphocytic leukaemia (CLL) and of normal individuals were depleted of EAC3b- or EAC3d-rosette-forming cells (RFC), respectively and assayed for K-cell activity in a system measuring antibody-dependent-cell-mediated cytotoxicity (ADCC). K-cell activity was found to be associated with a cell population bearing receptors for C3b.
D000920:Antibody-Dependent Cell Cytotoxicity; D001665:Binding Sites; D003176:Complement C3 / Q000378:metabolism*; D006801:Humans; D007141:Immunoglobulin Fc Fragments; D007694:Killer Cells, Natural / Q000276:immunology*; D007945:Leukemia, Lymphoid / Q000276:immunology*; D012397:Rosette Formation
D003176:Complement C3; D007141:Immunoglobulin Fc Fragments