Vendor differences in starvation-induced gastric ulceration.
The incidence of starvation-induced gastric lesions was observed in Sprague-Dawley rats obtained from four different vendors (ARS/Sprague-Dawley, Hilltop, Holtzman, and Charles River). Food was withheld for 5 days from rats weighing 150, 200, 260 or 330 g. Glandular lesions occurred in 150 g rats; rumenal lesions occurred in 200+ rats. ARS/Sprague-Dawley rats developed more glandular lesions, whereas Hilltop rats developed more rumenal lesions.
D000818:Animals; D000830:Animals, Laboratory; D001835:Body Weight; D008297:Male; D051381:Rats; D013217:Starvation / Q000150:complications*; D013276:Stomach Ulcer / Q000209:etiology*