title: The absence of sensitivity changes of the rabbit oviduct to phenylephrine and isoproterenol during early gestation.
abstract: The response of the rabbit perfused oviduct in vivo to phenylephrine (PE), isoproterenol (ISO) and epinephrine (EPI) was studied to determine if a purported change from alpha-adrenergic receptor dominance to beta-adrenergic receptor dominance during early gestation occurs (i.e. prior to implantation). The response of the tissue to PE did not change during early gestation, even in the presence of beta-receptor blockade by propranolol. The response to ISO of the PE-stimulated oviduct also did not change. However, the dose-response curve to EPI was shifted horizontally to the right 4 days after mating suggesting a tissue desensitization. It was concluded that the decreased oviductal sensitivity to EPI observed during early gestation could not be attributed to a change from alpha-receptor dominance to beta-receptor dominance.
mesh_terms: D000818:Animals; D004347:Drug Interactions; D004837:Epinephrine / Q000494:pharmacology; D005187:Fallopian Tubes / Q000187:drug effects*; D005260:Female; D005865:Gestational Age; D007545:Isoproterenol / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010656:Phenylephrine / Q000494:pharmacology*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D011433:Propranolol / Q000494:pharmacology; D011817:Rabbits
chemical_list: D010656:Phenylephrine; D011433:Propranolol; D007545:Isoproterenol; D004837:Epinephrine