title: [Pharmacokinetic studies of "Pharmachem" tylosin with healthy and infectious epididymitis-affected rams].
abstract: The retention in blood and the excretion with semen were followed up of tylosin-base, product of the State Economic Corporation "Pharmachim" (People's Republic of Bulgaria). It was found that at muscular application (12 mg/kg) the preparation is resorbed at the site of injection and is retained at a therapeutic level concentration in the blood of rams in the course of 24 to 26 hours. Tylosin gains access to the testes and is excreted with the semen at the same rate as in infectious epididymitis-intact rams. No correlation has been observed between the blood level of tylosin and the content of tylosin in the spermal plasma. The single treatment of rams with tylosin at the dosing cited above is not able to arrest the excretion of Brucella organisms with the semen, and does not improve its morphologic composition.
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001702:Biopharmaceutics; D002002:Brucella / Q000187:drug effects; D002031:Bulgaria; D004341:Drug Evaluation / Q000662:veterinary; D004823:Epididymitis / Q000188:drug therapy / Q000662:veterinary*; D007700:Kinetics; D007933:Leucomycins / Q000627:therapeutic use*; D008297:Male; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy*; D013094:Spermatozoa / Q000187:drug effects; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D007933:Leucomycins
vernacular_title: Niakoi farmakokinetichni prouchvaniia vurkhu tilozin "Farmakhim" pri zdravi i bolni ot zarazen epididimit kochove.