Lecithin changes in murine Mycoplasma pulmonis respiratory infection.
We examined the lipid content of bronchoalveolar (BA) washes from both mice and rats infected with Mycoplasma pulmonis, an etiological agent of murine pneumonia. During a 30-day period after intranasal inoculation, the total lipid content from infected and control rats (in milligrams per animal) remained relatively equal and unchanged. The saturated, unsaturated, and total lecithin contents in infected rats (in milligrams per animal) all increased. The maximum lecithin values were detected at 7 to 10 days after infection; later, the levels fell to control values. There was essentially no change in any lecithin value from uninfected animals. Although in BA washes from infected animals the mass of disaturated lecithins increased, the percentage of this fraction in the total lecithin pool decreased. The fatty acids of the lecithins from BA washes of infected mice had significantly less palmitic and significantly more oleic and linoleic acids than the lecithins isolated from the BA washes of control animals. Both the relative decrease in the mass of disaturated lecithins in the BA washes and the increase in the percentage of esterified unsaturated fatty acids in the lecithins may be directly related to the reduced lung function reported to occur during the course of murine M. pulmonis pneumonia.
D000818:Animals; D005227:Fatty Acids / Q000502:physiology; D005231:Fatty Acids, Unsaturated / Q000502:physiology; D005856:Germ-Free Life; D008170:Lung Compliance; D051379:Mice; D009175:Mycoplasma Infections / Q000503:physiopathology*; D011663:Pulmonary Surfactants / Q000502:physiology*; D051381:Rats
D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D011663:Pulmonary Surfactants