[Antimalarial 6-aminoquinolines. VIII. 2- and 4-amino derivatives (author's transl)].
Ten 2- or 4-amino derivatives 10b-I of 6-(4-diethylamino-1-methylbutylamino)-5,8-dimethoxyquinoline were synthesised with the aim of studying the influence of these substituents on antimalarial activity and toxicity of the 6-aminoquinolines. The 4-dialkylamino derivatives 10c-h were less active against P. vinckei (mouse) than 4-alkoxy derivatives. The 4-amino derivative 10b was inactive.
D000634:Aminoquinolines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000627:therapeutic use; D008288:Malaria / Q000188:drug therapy; D008722:Methods; D051379:Mice; D013329:Structure-Activity Relationship
D000634:Aminoquinolines; D000962:Antimalarials
Gegen Malaria wirksame 6-Aminochinoline. VIII. 2-und 4-Aminoderivate.