title: [Analysis of the biological effect of city smog extract. I. Cytotoxicity of city smog extract from an urban area and of polycyclic aromatic hydrocarbons on mouse macrophages in vitro (author's transl)].
abstract: We analyzed the cytotoxic effect of a city smog extract from a large urban area, employing mouse macrophages in vitro. In parallel experiments we tested carcinogenic and non carcinogenic polycyclic aromatic hydrocarbons: benzo(a)pyrene, 7, 12-dimethylbenzanthracene, pyrene and anthracene. City smog extract induced a dose-dependent reduction of cell viability and an alteration in cell membrane permeability. In contrast to city smog extract the carcinogenic and non carcinogenic polycyclic aromatic hydrocarbons produced no detectable cytotoxic effects in the dose range we analyzed. Possible implications of the cytotoxic effect of city smog extract on the lung are discussed.
mesh_terms: D000393:Air Pollutants / Q000009:adverse effects*; D000397:Air Pollution / Q000032:analysis; D000818:Animals; D000873:Anthracenes / Q000009:adverse effects; D001580:Benzopyrenes / Q000009:adverse effects; D002273:Carcinogens; D004391:Dust; D005860:Germany, West; D008264:Macrophages / Q000187:drug effects*; D051379:Mice; D009153:Mutagens / Q000009:adverse effects; D011721:Pyrenes / Q000009:adverse effects; D012905:Smog / Q000032:analysis; D014505:Urban Population
chemical_list: D000393:Air Pollutants; D000873:Anthracenes; D001580:Benzopyrenes; D002273:Carcinogens; D004391:Dust; D009153:Mutagens; D011721:Pyrenes; D012905:Smog
vernacular_title: Untersuchung der biologischen Wirkung von atmosphärischen Feinstaubextrakten. I. Prüfung der zytotoxischen Wirkung eines Feinstaubextraktes aus einem Ballungsgebiet und von polyzyklischen Kohlenwasserstoffen an Mäusemakrophagen in vitro.