title: [Mutagenic process in bacteriophage T4B after long-term exposure to a mutagen].
abstract: Bacteriophage T4B was continuously passed on solid media in the presence of 5-bromodeoxyuridine in two simultaneous experiments. The subsitutions of amino acids were registered, and in one of the experiments biological changes were revealed in non-optimal conditions. Calculations has shown that the number of amino acid substitutions observed corresponds to at least 140--200 fixed mutations. The possibility of the mutation fixation via selection is discussed and their relative neutrality is suggested.
mesh_terms: D000596:Amino Acids / Q000235:genetics; D005075:Biological Evolution; D001973:Bromodeoxyuridine / Q000494:pharmacology*; D055598:Chemical Phenomena; D002621:Chemistry; D003090:Coliphages / Q000187:drug effects / Q000502:physiology*; D004279:DNA, Viral / Q000235:genetics; D008954:Models, Biological; D009153:Mutagens / Q000494:pharmacology*; D009154:Mutation / Q000187:drug effects; D013045:Species Specificity; D014764:Viral Proteins / Q000235:genetics
chemical_list: D000596:Amino Acids; D004279:DNA, Viral; D009153:Mutagens; D014764:Viral Proteins; D001973:Bromodeoxyuridine
vernacular_title: Mutatsionnyĭ protsess u bakteriofaga T4B pri dlitel'nom mutagennom vozdeĭstvii.