[Genotypical characteristics of the immunological Vi-antibody maturation depending on the effect of Vi-antigen deposit in the body].
The authors carried out a comparative analysis of the changes in the antibody synthesis and their immunological maturation in the immunization with various doses of the Vi-antigen of linear rats differing by the capacity to deposit this antigen. August rats with a high capacity to deposit the Vi-antigen (in comparison with Wistar rats in which this capacity was less)  were characterized by an increased level of highly avid antibodies. The interlinear differences were found in the character of the changes in the antibody synthesis depending on the immunizing dose of the antigen. Genotypical peculiarities of the immunological maturation of the antibodies were demonstrated. The authors suppose that the described phenomenon was genetically determined and referred to the factors determining the individual immunological reactivity. In the choice of the optimal immunizing doses of the antigens the authors recommend complex determination of the antibody level and the degree of their avidity.
D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis*; D000917:Antibody Formation; D000942:Antigens, Bacterial / Q000008:administration & dosage*; D004306:Dose-Response Relationship, Immunologic; D005838:Genotype; D051381:Rats; D011919:Rats, Inbred Strains; D012485:Salmonella typhi / Q000276:immunology*
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial
Genotipicheskie osobennosti immunologicheskogo sozrevaniia Vi-antitel v zavisimosti ot effekta deponirovaniia Vi-antigena v organizme.