RNA biosynthesis in lymphocytes from various chronic diseases (cytochemical, cytoautoradiographic, optic and electronic study).
In lymphocytes of patients with myasthenia gravis and systemic lupus erythematosus high indices of uridin labelling were very often encountered, similar to those observed in evident malignant diseases such as chronic lymphocytic leukemia and Hodgkin's disease. The electron cytoautoradiographic investigations showed particularly that large sized nucleoli and even the giant ones are sometimes not the result of an RNA-hypersynthesis but of an RNA accumulation. The utility of such data for the therapy with immunodepressing drugs is discussed.
D002908:Chronic Disease; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008180:Lupus Erythematosus, Systemic / Q000473:pathology*; D008214:Lymphocytes / Q000378:metabolism*; D009157:Myasthenia Gravis / Q000473:pathology*; D009369:Neoplasms / Q000473:pathology*; D012313:RNA / Q000096:biosynthesis*
D007166:Immunosuppressive Agents; D012313:RNA