Comparison of the mode of immunopotentiating action of BCG and wax D. II. Effect on the methylcholanthrene carcinogenesis.
The effects of BCG and wax D on methylcholanthrene (MCA) carcinogenesis in mice were studied. BCG given 8 weeks after MCA administration conferred a significant protection against carcinogenesis. When given either on the same day as MCA injection or 4 weeks after MCA, BCG slightly increased tumor incidence. Wax D provided a marked protection against tumor development when given 4 weeks after MCA. An enhanced tumor development was obtained, when wax D was administered either on the day of MCA injection or 8 weeks after MCA. These results indicated that the effects of BCG and wax D on MCA carcinogenesis varied with the timing of administration. When BCG and wax D increased the level of delayed type hypersensitivity (DTH) at the initiating time of tumor development, a protection against carcinogenesis was obtained. On the other hand, BCG and wax D enhanced tumor development, when it increased antibody formation at the time of initiation of tumor development.
D000818:Animals; D001500:BCG Vaccine / Q000627:therapeutic use; D006017:Glycolipids / Q000627:therapeutic use; D008297:Male; D008748:Methylcholanthrene; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000276:immunology* / Q000517:prevention & control
D001500:BCG Vaccine; D006017:Glycolipids; D008748:Methylcholanthrene; C009681:Wax D