The effect of anaesthesia and total hip replacement on the phytohaemagglutinin and concanavalin A responses of lymphocytes.
Cell-mediated immunity as a part of the immune host defence mechanisms was studied in 12 patients undergoing total hip replacement surgery. The combined anaesthesia used did not lower the phytohaemagglutinin (PHA) and concanavalin A (Con A) responses of lymphocytes in whole blood culture during the first hour of anaesthesia before the beginning of surgery, but a clear decrease occurred after the beginning of the operation. The mitogenic responses started to recover immediately after the operation, but complete recovery was not obtained during the follow-up of 9-14 days.
D000368:Aged; D000758:Anesthesia; D003208:Concanavalin A / Q000494:pharmacology*; D005260:Female; D005500:Follow-Up Studies; D006621:Hip Joint / Q000601:surgery*; D006801:Humans; D007595:Joint Prosthesis; D037102:Lectins / Q000494:pharmacology*; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged
D037102:Lectins; D003208:Concanavalin A