Effects of actinomycin D on brain RNA synthesis and discrimination learning in the goldfish (Carassius auratus).
Intracranial injection of actinomycin D 2 microgram inhibited about 70% of the brain RNA synthesis from 3 hr to 4 days after injection in the goldfish. Under these conditions, fish were given 4-day-training of visual discrimination between a card with vertical stripes and one with horizontal stripes. Fish injected intracranially with actinomycin D showed deficits in between-day retention (long-term memory) but not interruption of within-day acquisition (short-term memory). It is suggested that brain RNA synthesis is necessary only for the formation of long-term memory but not short-term memory.
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D003609:Dactinomycin / Q000494:pharmacology*; D004193:Discrimination Learning / Q000187:drug effects*; D006054:Goldfish; D009043:Motor Activity / Q000187:drug effects; D012313:RNA / Q000096:biosynthesis*; D013997:Time Factors
D003609:Dactinomycin; D012313:RNA