[Effect of N'-methyl-N'-beta-chlorethylbenzaldehyde hydrazone on aerobic glycolysis in Ehrlich ascites cells].
N'-Methyl-N'-beta-chloroethylhydrazones are potent inducers of aerobic glycolysis of Ehrlich ascites carcinoma (E.A.) cells without influencing directly the respiration which is reduced only after glycolysis is at its maximum. This induction of glycolysis is not influenced by simultaneous blocking of respiration by potassium cyanide. A primary attack on the cell membrane leading to an increased glucose influx is discussed because of the in vitro inhibition of these beta-chloroethylhydrazones of glyceraldehyde-3-phosphate oxidoreductase.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000201:enzymology / Q000378:metabolism; D003486:Cyanides; D004140:Dinitrophenols; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000037:antagonists & inhibitors; D006019:Glycolysis / Q000187:drug effects*; D006835:Hydrazones / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009588:Nitrogen Mustard Compounds / Q000627:therapeutic use*; D010101:Oxygen Consumption / Q000187:drug effects; D011344:Procarbazine
D003486:Cyanides; D004140:Dinitrophenols; D006835:Hydrazones; D009588:Nitrogen Mustard Compounds; D011344:Procarbazine; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases
Zur Wirkung von N'-Methyl-N'-beta-chloräthyl-benzaldehyd-hydrazonen auf die aerobe Glykolyse der Ehrlich-Ascites-Zelle.