title: [Effect of coumarin on the livers of DBA/2J and CH3/HeJ mice].
abstract: 32 weeks chronic feeding of DBA/2J- as well as CH3/HeJ-mice with 0.5 and 1.0% coumarin, respectively, in the diet, caused minimal increases of glutamate-oxalatetransaminase, gamma-glutamyltransferase and sorbitdehydrogenase activities in the serum only, when approximately 2 g coumarin/kg daily were administered. Neither macroscopic nor microscopic examination of liver tissue revealed any pathological alterations caused by coumarin. Correspondingly the animals were unaffected in their behaviour and growth during the coumarin loading.
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001835:Body Weight / Q000187:drug effects; D003374:Coumarins / Q000494:pharmacology* / Q000633:toxicity; D004032:Diet; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D051379:Mice; D008811:Mice, Inbred DBA; D008815:Mice, Inbred Strains; D013385:Succinate Dehydrogenase / Q000097:blood
chemical_list: D003374:Coumarins; D013385:Succinate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
vernacular_title: Untersuchungen über die Wirkung von Cumarin auf die Leber von DBA/2J- und CH3/HeJ-Mäusen.