[Inflammation and host resistance against tumours. II. -- Antagonism between bradykinin and a fraction isolated from the supernatant of cultured malignant cells on the spreading of macrophages (author's transl)].
When murine peritoneal macrophages are incubated in presence of 10(-6) to 10(-8) M of bradykinin, their spreading is increased. When macrophages are incubated in presence of a low molecular weight fraction of the supernatant from cultured Lewis carcinoma's cells (AP) their spreading is decreased. When macrophages are incuated first with bradykinin and later on with AP, no inhibition of spreading is observed. When macrophages are incubated first with AP and later on with bradykinin, the increase of spreading is not observed.
D001920:Bradykinin / Q000494:pharmacology; D002277:Carcinoma / Q000503:physiopathology*; D002465:Cell Movement / Q000187:drug effects; D002478:Cells, Cultured; D008264:Macrophages / Q000502:physiology*; D009374:Neoplasms, Experimental / Q000503:physiopathology
D001920:Bradykinin
Inflammation et résistance antitumorale. II. -- Effets antagonistes de la bradykinine et d'une fraction isolée d'un surnageant de culture de cellules malignes sur l'étalement des macrophages.