[Blood coagulation studies of therapeutic abortion induced by 15-methyl-prostaglandin F2 alpha].
10 women with unwanted pregnancies in the first and second trimester were terminated by use of intramuscular injections of 15-Methyl-PGF2alpha. Studies of bleeding and recalcification time, platelet count, levels of heat-fibrin, prothrombin, partial thromboplastin time, platelet adhesiveness and heparinocytes were performed before treatment. 30 minutes, 4 and 8 hours after beginning of 15-Methyl-PGF2alpha-administration, 2 hours after the expulsion of the product of conception and 24 hours after first investigation. Prothrombin decreased during treatment with 15-Methyl-PGF2alpha and did not obtain the starting value 24 hours after first investigation. Platelet count showed an equal attitude. The time of recalcification increased continuous. Heparinocytes continuous decreased up to 2 hours after expulsion of the product of conception. 24 hours after first investigation a significant ascent was noticed. The results of the studies on coagulation did not indicate a strong injury of coagulation system. They suggest the positive estimation of termination of pregnancy in the first and second trimester with 15-Methyl-PGF2alpha.
D000030:Abortion, Missed / Q000188:drug therapy; D000032:Abortion, Therapeutic / Q000379:methods*; D001772:Blood Cell Count; D001777:Blood Coagulation / Q000187:drug effects*; D005260:Female; D005337:Fibrin / Q000378:metabolism; D006801:Humans; D010973:Platelet Adhesiveness / Q000187:drug effects; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D011461:Prostaglandins F, Synthetic / Q000494:pharmacology* / Q000627:therapeutic use
D011461:Prostaglandins F, Synthetic; D005337:Fibrin
Gerinnungsuntersuchungen bei 15-Methyl-Prostaglandin-F 2alpha-induzierten therapeutischen Abortus.