title: Derivatives of benzimidazole: vasodilator activity of 2-(p-chloro-alpha-hydroxybenzyl)-benzimidazole hydrochloride. Preliminary study.
abstract: The effects of 2-(p-chloro-alpha-hydroxybenzyl)-benzimidazole hydrochloride (HBBPC) have been studied in the rabbit and rat. Most of these studies were performed comparatively with reference vasodilators and papaverine. HBBPC vasodilator activity is nearly the same as that of papaverine in the isolated rabbit ear. The characteristic of the vasoactive action of HBBPC seems to reside in its duration. The mechanism of action of HBBPC seems of peripheral type, that is to say it acts on the vascular smooth muscle.
mesh_terms: D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology*; D004431:Ear, External / Q000098:blood supply; D005260:Female; D006614:Hindlimb / Q000098:blood supply; D066298:In Vitro Techniques; D008297:Male; D010477:Perfusion; D011817:Rabbits; D051381:Rats; D012039:Regional Blood Flow / Q000187:drug effects; D014665:Vasodilator Agents
chemical_list: D001562:Benzimidazoles; D014665:Vasodilator Agents