Morphologic and biologic correlation of hyperplastic and neoplastic renal lesions occurring in Buffalo and Fischer strain rats ingesting n-4-(4'-fluorobiphenyl) acetamide.
Hyperplastic and neoplastic lesions of the kidney induced in inbred Buffalo and Fisher strain rats with 0.04% N-4-(4'-fluorobiphenyl) acetamide were transplanted s.c. to rats of the same strain. Hyperplastic renal lesions ("areas" or nodules) did not survive and grow. Carcinomas of the kidney grew and killed the animals. Growth was related to the size and the degree of differentiation of the carcinoma. It is concluded that the histologic pattern of hyperplastic and neoplastic lesions of the kidney can be correlated with the results obtained on transplantation.
D000081:Acetamides / Q000009:adverse effects*; D000230:Adenocarcinoma / Q000139:chemically induced / Q000473:pathology; D000818:Animals; D005260:Female; D006965:Hyperplasia / Q000139:chemically induced / Q000473:pathology; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D007680:Kidney Neoplasms / Q000139:chemically induced / Q000473:pathology*; D008297:Male; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains
D000081:Acetamides