title: Absence of Chromosome Damage in the bone marrow of rats fed detergent actives for 90 days.
abstract: Four detergent actives, sodium lauryl sulphate, DOBS 055, Dobanol 25 sulphate LCU and Dobanol 25 sulphate HCB, were fed to rats in the diet for 90 days at the maximum tolerated dose, 1.13 percent active ingredient in each case. Sodium lauryl sulphate and DOBS 055 were also fed at half this concentration. Chromosome preparations were made from the bone marrow and scored for the presence of rearrangements, chromatid gaps and breaks and isochromatid gaps and breaks. The four detergent actives were found to have no effect on the chromosomes of rat bone marrow cells.
mesh_terms: D001853:Bone Marrow / Q000648:ultrastructure; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects*; D003902:Detergents / Q000494:pharmacology*; D004032:Diet; D009153:Mutagens; D012967:Sodium Dodecyl Sulfate / Q000494:pharmacology; D013997:Time Factors
chemical_list: D003902:Detergents; D009153:Mutagens; D012967:Sodium Dodecyl Sulfate