Anaphylactoid responses in rats.
The relative activities of dextran, mannan and ovomucoid as agents inducing anaphylactoid responses in rats vary with the route of injection, mannan being the most active especially by the intradermal route. All of these responses are potentiated by pretreatment with insulin and inhibited by glucose. Carrageenan and concanavalin A are also active but only by the subcutaneous route. Whereas the concanavalin A response is potentiated by insulin, that of carrageenan is reduced. There are therefore at least three classes of agents capable of inducing anaphylactoid responses in rats.
D000707:Anaphylaxis / Q000276:immunology*; D000818:Animals; D002351:Carrageenan / Q000494:pharmacology; D003208:Concanavalin A / Q000494:pharmacology; D003911:Dextrans / Q000494:pharmacology; D007271:Injections, Intradermal; D007274:Injections, Intraperitoneal; D007279:Injections, Subcutaneous; D007328:Insulin / Q000494:pharmacology; D008351:Mannans / Q000494:pharmacology; D010059:Ovomucin / Q000494:pharmacology; D051381:Rats
D003911:Dextrans; D007328:Insulin; D008351:Mannans; D003208:Concanavalin A; D010059:Ovomucin; D002351:Carrageenan