title: Effects of 3-trifluoromethyl-alpha-ethylbenzhydrol (RGH-3332), a new enzyme inducer, on the microsomal drug metabolism. Part I.
abstract: Intensity and duration of action of several compounds which are metabolized in the liver, are reduced in rats following pretreatment with 3-trifluoromethyl-alpha-ethylbenzhydrol (RGH-3332, Zixoryn), e.g., hexobarbital, methohexitone, glutethimide, hydroxymephenesine, chlorzoxazone, zoxazolamine, ketamine, chlordiazepoxide, diphenylhydantoin, ethylmorphine and pentylenetetrazol, hydroquinone, acenocumarol, respectively. Hypnotic effect of barbital is not altered by RGH-3332. Hexobarbital, meprobamate, mephenesine, nikethamide, canrenone, metyrapone, antipyrine, bromsulphophthalein, inocyanin green, bilirubin disappearance are enhanced, excretion of ascorbic acid is increased after RGH-3332 treatment. The effect of RGH=3332 is inhibited by D,L-ethionine. Hepatic cytochrome P450 concentration is increased following treatment with RGH-3332. Results of in vivo studies proved that 3-trifluoromethyl-alpha-ethylbenzhydrol has enzyme inducing activity.
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000652:urine; D001559:Benzhydryl Compounds / Q000494:pharmacology*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004790:Enzyme Induction / Q000187:drug effects*; D005036:Ethylmorphine / Q000378:metabolism; D005260:Female; D006873:Hydroquinones / Q000378:metabolism; D006993:Hypnotics and Sedatives / Q000378:metabolism; D008862:Microsomes, Liver / Q000187:drug effects*; D009125:Muscle Relaxants, Central / Q000378:metabolism; D010433:Pentylenetetrazole / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D010672:Phenytoin / Q000378:metabolism; D051381:Rats
chemical_list: D001559:Benzhydryl Compounds; D006873:Hydroquinones; D006993:Hypnotics and Sedatives; D009125:Muscle Relaxants, Central; D004364:Pharmaceutical Preparations; D010672:Phenytoin; D003577:Cytochrome P-450 Enzyme System; D001205:Ascorbic Acid; D005036:Ethylmorphine; D010433:Pentylenetetrazole