The effect of cyclophosphamide on the centromere separation sequence in Chinese hamster spermatogonia.
The sequence of centromere separation in spermatogonial chromosomes of untreated and cyclophosphamide-treated Chinese hamsters is described. Centromeres of chromosome 1 and 2 separated much earlier than all other chromosomes, especially 6-8. Cyclophosphamide significantly inhibits the centromere separation in all chromosome groups but does not alter the sequence of separation.
D000818:Animals; D002503:Centromere / Q000187:drug effects*; D002875:Chromosomes / Q000187:drug effects*; D006224:Cricetinae; D003520:Cyclophosphamide / Q000494:pharmacology*; D008297:Male; D013093:Spermatogonia / Q000187:drug effects*; D013094:Spermatozoa / Q000187:drug effects*; D013997:Time Factors
D003520:Cyclophosphamide