Physostigmine reversal of postoperative somnolence.
The effects of physostigmine on reversal of post-operative somnolence following general anaesthesia were evaluated in 187 patients. Significant reversal of anaesthetic-induced post-operative somnolence was observed in those patients receiving physostigmine when compared to a control group. These results suggest that general anaesthesia with halothane may be included in those situations where central nervous system depression may be reversed by administration of physostigmine. Cholinergic side-effects observed with physostigmine administration were minimal.
D000293:Adolescent; D000328:Adult; D000758:Anesthesia; D006801:Humans; D008875:Middle Aged; D010830:Physostigmine / Q000494:pharmacology*; D012890:Sleep / Q000187:drug effects*; D013997:Time Factors
D010830:Physostigmine