[Cytostatic effect of cyclophosphane on esophageal tumors and epithelium of mice].
Investigation of cytostatic activity of cyclophosphamide in sarcoma 37 and esophagus epithelium in albino mice with respect to the diurnal rhythm of mitotic activity and the number of labeled nuclei was performed. Apparently the tumour cells in the G1-phase and at the beginning of the S-phase of the mitotic cycle were the most sensitive to the inhibitory effect of this drug. During the completion of the DNA-synthesis period the cell resistance to the action of the cytostatic increased. Cells at the G1-phase of the mitotic cycle were sensitive to the inhibitory action of cyclophosphane in the esophageal epithelium.
D000818:Animals; D003520:Cyclophosphamide / Q000494:pharmacology / Q000627:therapeutic use*; D004247:DNA / Q000096:biosynthesis; D004285:Dogs; D004848:Epithelium / Q000187:drug effects; D004947:Esophagus / Q000166:cytology / Q000187:drug effects*; D008297:Male; D051379:Mice; D008940:Mitotic Index / Q000187:drug effects; D051381:Rats; D012511:Sarcoma 37 / Q000188:drug therapy*
D003520:Cyclophosphamide; D004247:DNA
Issledovanie tsitostaticheskogo deĭstviia tsiklofosfana v opukholi i épitelii pishchevoda u mysheĭ.