title: Sulfisoxazole-induced thrombocytopenic purpura. Immunologic mechanism as cause.
abstract: During treatment of brucellosis with sulfisoxazole, tetracycline, and streptomycin sulfate, severe thrombocytopenic purpura developed in a young farmer. Verification for an immune mechanism was provided by clinical challenge with a small dose of sulfisoxazole that caused recurrence of thrombocytopenia and by serologic laboratory test results that detected a serum factor causing platelet agglutination requiring the presence of sulfisoxazole. The original antigenic stimulation was considered to come from drinking cows' milk contaminated with sulfonamide drugs. Cross-reactivity with some other sulfonamide drugs was demonstrated.
mesh_terms: D000328:Adult; D000818:Animals; D001792:Blood Platelets / Q000187:drug effects; D002006:Brucellosis / Q000188:drug therapy; D003429:Cross Reactions; D004342:Drug Hypersensitivity / Q000209:etiology*; D006801:Humans; D008297:Male; D008892:Milk / Q000032:analysis; D011696:Purpura, Thrombocytopenic / Q000139:chemically induced*; D013444:Sulfisoxazole / Q000009:adverse effects* / Q000276:immunology / Q000627:therapeutic use
chemical_list: D013444:Sulfisoxazole