title: The in vitro effects of calcium and potassium in resensitization of tracheal smooth muscles of the allergized guinea pig.
abstract: Tracheal smooth muscle obtained from allergized guinea pigs gives rise in vitro to two-phase cycles of responsiveness to antigen administration desensitization produced immediately after a conditioning antigen dose, followed by resensitization within 4 h. As in the case of resensitization to a drug, resensitization to an antigen is a Ca++- and K+-dependent phenomenon. A comprehensive receptor model of the chemical excitatory action of antigen in cells is consistent with a Ca++-dependent resensitization phenomenon in the allergized systems. On the other hand, the results bear weight against both a 'pharmacological mediator-depletion theory' and an 'antibody saturation-desaturation theory', which have been invoked to explain desensitization and resensitization to antigen in allergized systems.
mesh_terms: D000818:Animals; D000941:Antigens; D002118:Calcium / Q000494:pharmacology*; D002245:Carbon Dioxide / Q000378:metabolism; D003888:Desensitization, Immunologic; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006168:Guinea Pigs; D006967:Hypersensitivity / Q000276:immunology*; D008297:Male; D009130:Muscle, Smooth / Q000276:immunology*; D013997:Time Factors; D014132:Trachea / Q000276:immunology
chemical_list: D000941:Antigens; D002245:Carbon Dioxide; D002118:Calcium