Potential biologically active agents. X. Synthesis of 3-arylimino-2-indolinones, and their 1-methyl- and 1-morpholino/piperidinomethyl derivatives as excystment and cysticidal agents against Schizopyrenus russelli.
Isatin and N -methylisatin have been condensed with alkylaminobenzoates to furnish 3-arylimino-2-indolinones and 1-methyl-3-arylimino-2-indolinones respectively. 3-Arylimino-2-indolinones were then subjected to Mannich reaction conditions to yield 1-morpholino/piperidinomethyl-3-arylimino-2-indolinones. The compounds thus synthesised were evaluated for their ability to cause excystment and cysticidal activity against Schizopyrenus russelli.
D000563:Amebicides / Q000138:chemical synthesis*; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D010880:Piperidines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats
D000563:Amebicides; D007211:Indoles; D010880:Piperidines