Effects of manganese, calcium, magnesium and lithium on the ouabain-induced seizure.
The effects of the intraventricularly administered cations (Mn2+, Ca2+, Mg2+ and Li+) against the seizure induced by ouabain (3 microgram) were investigated. Mn2+, Ca2+ and Mg2+ caused definite sedation and decreased locomotor activity. But Li+ was without significant behavioral effect at the doses applied. Among the cations used, Mn2+, Ca2+ and Mg2+ showed significant anticonvulsive effect on the ouabain-induced seizure. In comparison, on the dose and molar-to-molar basis, the potency of anticonvulsive action was in the following order: Mn2+ greater than Ca2+ greater than Mg2+. On the contrary, the higher dose of Li+ potentiated the ouabain-induced seizure. The importance of the increased Ca2+ level in the extracellular space or the inhibition of Ca2+ uptake as the anticonvulsive effect of Ca2+, Mn2+ and Mg2+ was discussed.
D000818:Animals; D001519:Behavior / Q000187:drug effects; D002118:Calcium / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D008094:Lithium / Q000008:administration & dosage / Q000494:pharmacology*; D008274:Magnesium / Q000008:administration & dosage / Q000494:pharmacology*; D008345:Manganese / Q000008:administration & dosage / Q000494:pharmacology*; D010042:Ouabain; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology*
D008345:Manganese; D010042:Ouabain; D008094:Lithium; D008274:Magnesium; D002118:Calcium