title: Evolution of ageing.
abstract: An evolutionary view of ageing suggests that mortality may be due to an energy-saving strategy of reduced error regulation in somatic cells. This supports Orgel's 'error catastrophe' hypothesis and offers a new basis for the study of normal and abnormal ageing syndromes and of apparently immortal transformed cell lines.
mesh_terms: D000375:Aging; D000818:Animals; D005075:Biological Evolution; D002470:Cell Survival; D002471:Cell Transformation, Neoplastic; D005347:Fibroblasts / Q000502:physiology; D006801:Humans; D008660:Metabolism; D008954:Models, Biological; D014176:Protein Biosynthesis