Mutalomycin, a new polyether antibiotic taxonomy, fermentation, isolation and characterization.
Mutalomycin is a new metal-complexing polyether antibiotic produced by a strain of Streptomyces mutabilis NRRL 8088. The metabolite, a monocarboxylic acid, was isolated as the sodium salt C41H69NaO12. The structure of this polyether was established by X-ray analysis of its potassium salt C41H69KO12. Mutalomycin contains six heterocyclic rings and is structurally related to nigericin. The metabolite is active against gram-positive bacteria and Eimeria tenella (chicken coccidiosis).
D000818:Animals; D000906:Antibodies / Q000302:isolation & purification; D055598:Chemical Phenomena; D002621:Chemistry; D003049:Coccidiostats; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D009550:Nigericin / Q000031:analogs & derivatives; D013055:Spectrophotometry, Infrared; D013302:Streptomyces / Q000166:cytology / Q000378:metabolism*
D000906:Antibodies; D003049:Coccidiostats; C016007:mutalomycin; D009550:Nigericin