Formation of nucleoside 5'-phosphoramidates under potentially prebiological conditions.
Adenosine 5'-phosphoramidates form when solutions containing adenosine 5'-polyphosphates pnA (n greater than or equal to 3) or P1, P2-diadenosine 5'-diphosphate and amines are allowed to dry out. Mg ions catalyze these reactions. We have studied systems containing ammonia, imidazole, glycine, ethylenediamine and histamine. The yields of adenosine 5'-phosphoramidates range from 10-50% based on the nucleotide. The prebiotic significance of the reactions is discussed.
D000249:Adenosine Monophosphate / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D000255:Adenosine Triphosphate / Q000031:analogs & derivatives; D000588:Amines; D000641:Ammonia; D055598:Chemical Phenomena; D002621:Chemistry; D005029:Ethylenediamines; D005998:Glycine; D006632:Histamine; D007093:Imidazoles; D011122:Polyphosphates
D000588:Amines; D005029:Ethylenediamines; D007093:Imidazoles; D011122:Polyphosphates; D000249:Adenosine Monophosphate; C015651:adenosine 5'-phosphoramidate; D000641:Ammonia; D006632:Histamine; D000255:Adenosine Triphosphate; D005998:Glycine