title: Electrical activity in sympathetic fibres to hind limb muscles of the cat produced by hypothalamic stimulation.
abstract: Electrical stimulation of the "Defence Area" of the hypothalamus in anaesthetized cats was accomplished by stereotaxic placement of bipolar stainless steel electrodes; the spinal cord was sectioned at L4. The muscle blood flow in one hind limb was recorded with an electromagnetic flowmeter. Increases of between 100% and 300% were observed during hypothalamic stimulation. Electroneurographic recordings from small nerve filaments supplying tibialis anterior muscle revealed two populations of neurones whose activity was abolished by lumbar sympathectomy. It appears that the increased blood flow in skeletal muscle during stimulation of the hypothalamic "Defence Area" is brought about by a simultaneous inhibition of vasoconstrictor activity and increase in cholinergic vasodilator discharge.
mesh_terms: D000818:Animals; D001794:Blood Pressure; D002346:Carotid Sinus / Q000502:physiology; D002415:Cats; D004558:Electric Stimulation; D006614:Hindlimb / Q000098:blood supply / Q000294:innervation*; D007031:Hypothalamus / Q000502:physiology*; D007083:Iliac Artery / Q000294:innervation; D009132:Muscles / Q000098:blood supply / Q000294:innervation; D009638:Norepinephrine / Q000494:pharmacology; D012039:Regional Blood Flow; D013564:Sympathetic Nervous System / Q000502:physiology*; D014666:Vasomotor System / Q000502:physiology*
chemical_list: D009638:Norepinephrine