3-(3-Substituted prop-1-enyl)cephalosporins.
The synthesis of cephalosporin derivatives possessing a 3-substituted prop-1-enyl group at the 3 position is described. This was achieved using the reaction of vinylmagnesium chloride with the 3-formyl derivatives 1 to give a vinylcarbinol which readily underwent allylic rearrangements to give the desired side chains. The new derivatives exhibited potent in vitro and in vivo antibacterial activity.
D001419:Bacteria / Q000187:drug effects; D002511:Cephalosporins / Q000138:chemical synthesis*; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
D002511:Cephalosporins