title: Hydrocortisone effects on cell proliferation: specificity of response among various cell types.
abstract: The effect of 14 micrometer hydrocortisone (HC) on the proliferative activity of various vertebrate cell lines has been measured. Such activity in human deploid cell line WI-38 was enhanced by HC addition whereas in a number of other vertebrate cell lines under identical conditions HC was inhibitory to growth. We examined the effects of HC on normal human diploid cells other than WI-38; some were stimulated, some inhibited and some were unresponsive. The results suggest that cells derived from different human tissues retain in vitro some aspects of their cell-specific hormonal responses.
mesh_terms: D000375:Aging; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D002472:Cell Transformation, Viral; D004247:DNA / Q000096:biosynthesis; D006854:Hydrocortisone / Q000494:pharmacology*
chemical_list: D004247:DNA; D006854:Hydrocortisone