Effect of Methylene Blue on glutamate and reduced glutathione of rabbit erythrocytes.
Methylene Blue injected into rabbits resulted in increased glutamate, reduced glutathione and pyrrolid-2-one-5-carboxylate in erythrocytes. The increase in reduced glutathione was probably due to increased glutamate changing the feedback control of glutathione on gamma-glutamylcysteine synthetase.
D000818:Animals; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D005971:Glutamates / Q000378:metabolism*; D005978:Glutathione / Q000378:metabolism*; D008751:Methylene Blue / Q000494:pharmacology*; D011761:Pyrrolidonecarboxylic Acid / Q000378:metabolism; D011817:Rabbits
D005971:Glutamates; D005978:Glutathione; D011761:Pyrrolidonecarboxylic Acid; D008751:Methylene Blue