[Effect of sarcolysine on glutathione peroxidase and glutathione reductase activity in sarcoma C-45].
A drop of glutathione peroxidase and glutathione reductase activity was revealed in sarcoma C-45 at the period of its most intensive growth. Repeated sarcolysine injections (1.2 mg/kg, intraperitoneally) caused a sharp fall in the activity of both enzymes with a simultaneous reduction of the ratio of glutathione reductase and glutathione peroxidase activities. The important role of the glutathione enzyme redox system in the realization of antitumour action of the chemotherapeutic drugs is supposed.
D000818:Animals; D005979:Glutathione Peroxidase / Q000378:metabolism*; D005980:Glutathione Reductase / Q000378:metabolism*; D008297:Male; D008558:Melphalan / Q000627:therapeutic use*; D010544:Peroxidases / Q000378:metabolism*; D051381:Rats; D012513:Sarcoma, Experimental / Q000188:drug therapy* / Q000201:enzymology
D010544:Peroxidases; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D008558:Melphalan
Vliianie sarkolizina na aktivnost' glutationperoksidazy i glutationreduktazy v sarkome C-45.