title: Metabolism of testosterone by forehead skin of the roebuck (Capreolus capreolus).
abstract: Roebucks have a specialized region of skin on the forehead which contains sebaceous and apocrine glands that produce secretions used in territorial marking. These glands enlarge during the breeding season and regress after the rut as the testes regress. The metabolism of testosterone by this forehead skin in vitro was studied in two captive roebucks over the period of glandular enlargement and subsequent regression, and compared with that of dorsal skin. In May, June and July, both areas of skin actively metabolized testosterone and the metabolites detected were androstenedione, androstanedione, dihydrotestosterone, epiandrosterone, androsterone and 5alpha-androstanediols. There were no major differences in testosterone metabolism between the two body sites, although dorsal skin appeared to be more active in total metabolism than forehead skin. There was a peak in the extent of metabolism in June/July, with a subsequent gradual decline to December. The decline in metabolism occurred at a time when the associated glands were still enlarged, which suggests that the availability of androgen to the skin glands is determined not only by the amount of testosterone in the circulation, but also by a decrease in the metabolizing capacity of the tissue.
mesh_terms: D000735:Androstenedione / Q000378:metabolism; D000818:Animals; D001050:Apocrine Glands / Q000033:anatomy & histology / Q000378:metabolism; D001699:Biometry; D001947:Breeding; D003670:Deer / Q000378:metabolism*; D013196:Dihydrotestosterone / Q000378:metabolism; D005546:Forehead; D008297:Male; D012627:Sebaceous Glands / Q000033:anatomy & histology / Q000378:metabolism; D012867:Skin / Q000378:metabolism*; D013739:Testosterone / Q000378:metabolism*; D013997:Time Factors
chemical_list: D013196:Dihydrotestosterone; D013739:Testosterone; D000735:Androstenedione