title: Regulating the "size of mesh" in drug screening from statistical point of view demonstrated by a 2-step procedure of in vivo testing of antiviral compounds.
abstract: The present paper indicates how to regulate the "size of mesh" in drug screening by sample size and/or by modification of the statistical procedure used. Such a regulation is demonstrated on a 2-step procedure of in vivo testing of antiviral compounds as an example, by changing the rules of decision with the parameter R0. From the computed probabilities of discarding substances with defined effectivities, curves have been drawn which allow to read off immediately sample sizes and R0-values for a desired "size of mesh".
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D011336:Probability; D013223:Statistics as Topic
chemical_list: D000998:Antiviral Agents