[Studies on brewer's yeast (II). Phlogistic action (author's transl)].
Yeast has a phlogistic effect, and the inflammatory action of 10 brewer's yeast samples fractionated by autolysis and/or destruction of the cell wall was studied in rat hind paw. The yeast samples produced a dose dependent edema when given subcutaneously into the paw. The samples obtained by dissolution or destruction of the cell wall produced the most prominent edema and the phlogistic effect was more potent than commerical yeast powder. Peak of the response was noted 1 hour after injection and thereafter the grade of edema rapidly decreased. The pattern of swelling resembled that by dextran. The edema was partially (less than 40%) inhibited by anti-inflammatory drugs such as aspirin, aminopyrine, phenylbutazone, and indomethacin. Mannan, a main constituent of the yeast cell wall, produced a swelling similar to that observed with yeast samples and this edema was almost completely inhibited by cyprohepatdine, an anti-serotonin drug, but was not inhibited by diphenhydramine, an anti-histamine drug. The results suggest that there is a release of serotonin when brewer's yeast is given subcutaneously, thus producing a phlogistic effect.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D002473:Cell Wall / Q000032:analysis; D004487:Edema / Q000139:chemically induced*; D006633:Histamine Antagonists / Q000494:pharmacology; D008351:Mannans / Q000037:antagonists & inhibitors; D051381:Rats; D012702:Serotonin Antagonists / Q000494:pharmacology; D015002:Yeast, Dried / Q000037:antagonists & inhibitors
D000893:Anti-Inflammatory Agents; D006633:Histamine Antagonists; D008351:Mannans; D012702:Serotonin Antagonists