Termination of early pregnancy by ONO-802 (16,16-dimethyl-trans-delta2-PGE1 methyl ester).
ONO-802 was infused into the uterine cavity for the termination of early pregnancy in 45 healthy volunteers. Forty two (93%) of the 45 cases had complete abortions and two had incomplete abortions. Nine (20%) of the 45 volunteers complained of nausea, 7 (16%) vomited and 5 (11%) complained of abdominal pain. Neither diarrhea nor weakness was observed. These results suggest that ONO-802 is more acceptable for the termination of early pregnancy than is PGF2alpha.
D000028:Abortion, Induced; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D011458:Prostaglandins E / Q000009:adverse effects / Q000627:therapeutic use*; D013997:Time Factors
D011458:Prostaglandins E; D011374:Progesterone; D004958:Estradiol