The effects of d-amphetamine and temperature on p-cresol and pentylenetetrazol induced convulsions.
Each of twelve (12) rats were subjected to temperatures of 37c, 20c, and 4c in an environmental chamber. Seizure responses to p-cresol injections produced a U-shaped function, with minimal seizures occuring at 20c. Subsequent administration of d-amphetamine eliminated seizures, except at 4c, at which temperature only stereotyped behavior was observed. Environmental temperature effects on metrazol injections in a second group (N=72) seemed to increase linearly with respect to seizure susceptibility and mortality, although latency to first seizure was also a U-shaped function. The findings are discussed in the context of developing a model of epilepsy appropriate for behavioral research.
D000818:Animals; D001835:Body Weight; D003408:Cresols; D003913:Dextroamphetamine / Q000494:pharmacology*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D008297:Male; D010433:Pentylenetetrazole; D051381:Rats; D011930:Reaction Time; D012640:Seizures / Q000139:chemically induced* / Q000188:drug therapy / Q000401:mortality; D013696:Temperature
D003408:Cresols; D003913:Dextroamphetamine; D010433:Pentylenetetrazole