title: [Treatment of a case of grave orthostatic hypotension (Shy-Drager's syndrome) by an association of L-dopa and mono-amine-oxidase inhibitor (author's transl)].
abstract: The authors report a case of grave orthostatic hypotension (Shy-Drager's syndrome) with major postural disturbances. The biological test confirmed a catecholaminergic deficiency. After several drugs were tried unsucessfully, an association of L-Dopa and fractionated doses of mono-amine-oxydase inhibitor was proposed. The increase blood pressure was sufficient to block the diturbances of postural adaptation, without inducing hypertensive jerks. The functionnal result have been stable for three years, while the parkinsonian syndrome have shown little progression.
mesh_terms: D000368:Aged; D004341:Drug Evaluation; D005500:Follow-Up Studies; D006801:Humans; D007024:Hypotension, Orthostatic / Q000188:drug therapy*; D007520:Isocarboxazid / Q000008:administration & dosage / Q000627:therapeutic use*; D007980:Levodopa / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D013577:Syndrome
chemical_list: D007520:Isocarboxazid; D007980:Levodopa
vernacular_title: Syndrome de Shy et Drager: traitement d'une hypotension orthostatique grave par l'association L.dopa-inhibiteur de la mono-amine oxydase.