A fast-screening procedure for testing the effects of pollutants in mammals.
A compartmental analysis of r the radiorespirometric study of the metabolism of [14C]glucose is described. The model is applied to the study of the effects of CH3HgCl on this metabolism. Implications of the agreement between experiment and the mathematical model for the development of fast-screening experiments for detecting in vivo effects of pollutants and toxins are discussed.
D000818:Animals; D002245:Carbon Dioxide / Q000378:metabolism; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004785:Environmental Pollutants / Q000378:metabolism / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D008954:Models, Biological; D051381:Rats; D013997:Time Factors
D004785:Environmental Pollutants; D002245:Carbon Dioxide