title: Changes in serum lipids during treatment with norgestrel, oestradiol-valerate and cycloprogynon.
abstract: The serum concentrations of triglycerides, cholesterol, and free glycerol were determined in 23 climacteric women, before and after the administration of three different steroid drugs. Each drug was given within a period of 12 weeks (3 cycles). Period I: Norgestrel, 0.5 mg daily from the 12th to 21st day of each cycle. Period II: Oestradiol-valerate (Progynon) 2 mg daily from the 2nd to 21st day of each cycle. Period III: Oestradiol-valerate 2 mg from the 1st to 11th day followed by oestradiol-valerate 2 mg+0.5 mg dl-norgestresl from day 12 to 21 of each cycle (Cycloprogynon). A significant decrease in triglycerides was observed following the administration of norgestrel and Cycloprogynon, whereas oestradiol-valerate had no effect on the triglyceride levels. On the other hand, oestradiol-valerate, following a period of norgestrel, produced an increase in serum cholesterol levels.
mesh_terms: D000328:Adult; D002784:Cholesterol / Q000097:blood; D002979:Climacteric / Q000187:drug effects*; D004338:Drug Combinations; D004958:Estradiol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005990:Glycerol / Q000097:blood; D006801:Humans; D008055:Lipids / Q000097:blood*; D008875:Middle Aged; D009644:Norgestrel / Q000008:administration & dosage / Q000627:therapeutic use*; D014280:Triglycerides / Q000097:blood
chemical_list: D004338:Drug Combinations; D005230:Fatty Acids, Nonesterified; D008055:Lipids; D014280:Triglycerides; D009644:Norgestrel; D004958:Estradiol; D002784:Cholesterol; D005990:Glycerol