Anticonvulsant properties of some new derivatives of phensuccinimide.
Anticonvulsant properties of two new derivatives, of phenylsuccinimide, N-morpholinomethyl-3-bromophenyl-succinimide(IL-7) and N-amino-3-bromophenylsuccinimide (IL-16), were studied. It was stated that both compounds have similar acute toxicity and act longer than phensuximide. They are especially active in maximal electroshock seizure (MES) test. Their effectiveness against convulsions produced by pentetrazole is less than that of phensuximide. Their effectiveness against procaine and strychnine is similar, only one of tested compounds has very high potency against strychnine. This compound, IL-16, has also a different pattern of effect-time which is probably due to its different pharmacokinetic behaviour.
D000818:Animals; D000927:Anticonvulsants; D004597:Electroshock; D005260:Female; D007928:Lethal Dose 50; D051379:Mice; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D011343:Procaine / Q000037:antagonists & inhibitors; D013331:Strychnine / Q000037:antagonists & inhibitors; D013388:Succinimides / Q000494:pharmacology* / Q000633:toxicity; D013997:Time Factors
D000927:Anticonvulsants; D013388:Succinimides; D011343:Procaine; D013331:Strychnine; D010433:Pentylenetetrazole