Long-term co- trimoxazole treatment of chronic Salmonella carriers.
Long-term co-trimoxazole treatment (4-6 months) was tried in 7 chronic carriers of mainly Salmonella typhi and S. paratyphi B. No one had positive faecal cultures during treatment. Four faecal carriers were followed-up with regular cultures for at least 1 year after treatment and 3 of them remained negative. Long-term co-trimoxazole treatment seems to be well tolerated also in very old patients and may be worth trying also in cases where other antibiotics have failed.
D000368:Aged; D002353:Carrier State / Q000188:drug therapy*; D002675:Child, Preschool; D002908:Chronic Disease; D004338:Drug Combinations; D004341:Drug Evaluation; D005243:Feces / Q000382:microbiology; D005500:Follow-Up Studies; D006801:Humans; D012480:Salmonella Infections / Q000188:drug therapy*; D012484:Salmonella paratyphi B / Q000302:isolation & purification; D012485:Salmonella typhi / Q000302:isolation & purification; D013420:Sulfamethoxazole / Q000009:adverse effects / Q000627:therapeutic use*; D013997:Time Factors; D014295:Trimethoprim / Q000009:adverse effects / Q000627:therapeutic use*
D004338:Drug Combinations; D014295:Trimethoprim; D013420:Sulfamethoxazole