[Physiology and biochemistry of streptomycetes. XIII. Biosynthesis of paromomycin by Streptomyces albus var. metamycinus nov. var. supplied with 14C-glucose, 14C-glucosamine, 14C-2-desoxystreptamine and 14C-ribose].
Distribution of radioactivity in paromomycin ascertained after application of 14C-D-glucose, 14C-D-glucosamine, 14C-2-deoxystreptamine, respectively, 14C-D-ribose is taken as basis for a biosynthesis scheme: While ribose bound in the antibiotic originates from glucose by oxidation and following decarboxylation, glucosamine is formed via fructose-6-phosphate. Paromose I arises from glucosamine, but not the cyclohexan derivative 2-deoxystreptamine, whose biosynthesis pathway is directly branching off glucose.
D002250:Carbon Radioisotopes; D055598:Chemical Phenomena; D002621:Chemistry; D005944:Glucosamine / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D006595:Hexosamines / Q000378:metabolism*; D010303:Paromomycin / Q000096:biosynthesis*; D012266:Ribose / Q000378:metabolism*; D013302:Streptomyces / Q000378:metabolism*
D002250:Carbon Radioisotopes; D006595:Hexosamines; D010303:Paromomycin; D012266:Ribose; D005947:Glucose; C007265:2-deoxystreptamine; D005944:Glucosamine
Physiologie und Biochemie der Streptomyceten. XIII. Biosynthese von Paromomycin unter Einsatz von 14C-Glucose,-Glucosamin, -2-Desoxystreptamin und-Ribose durch Streptomyces albus var. metamycinus nov. var.