Effects of 3-trifluoromethyl-alpha-ethylbenzhydrol (RGH-3332), a new enzyme inducer on the central nervous system of rats. Part II.
3-Trifluoromethyl-alpha-ethylbenzhydrol (RGH-3332, Zixoryn) had been reported to induce the hepatic mixed function oxydase system similarly to phenobarbital [5]. CNS effects of both compounds were tested on immature rats, age 14 days, in the developmental phase of quick morphological and functional growth. A marked difference in total locomotor activity, exploratory behaviour and reaction to both compounds between immature and adult rats is reported. Toxicity of RGH-3332 is favourable in itself and in comparison to that of phenobarbital in both age groups. CNS effects are neglibile compared to the main effect, they can be observed only in 6--8fold doses eliciting maximum inductive response in case of RGH-3332, while CNS effects are caused by phenobarbital at lower doses than that required for maximum inductive response.
D000818:Animals; D000927:Anticonvulsants; D001559:Benzhydryl Compounds / Q000494:pharmacology* / Q000633:toxicity; D002491:Central Nervous System Agents; D004790:Enzyme Induction / Q000187:drug effects*; D005260:Female; D006993:Hypnotics and Sedatives; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009125:Muscle Relaxants, Central; D051381:Rats
D000927:Anticonvulsants; D001559:Benzhydryl Compounds; D002491:Central Nervous System Agents; D006993:Hypnotics and Sedatives; D009125:Muscle Relaxants, Central