Methyldopa and renal stones: a retrospective study.
A possible association between treatment with methyldopa and the occurrence of renal stones was sought by retrospectively comparing 54 hypertensive patients with calculi detected by X-ray examination with a control group matched for age and sex. Treatment with methyldopa was equally frequent in both groups. There was a significant excess of methyldopa use in a subgroup of 16 patients with bilateral calculi, but the drug could be the primary cause of stone formation in, at most, four of these patients. If methyldopa does cause renal stones, it is probably an uncommon event, but precipitation of the drug from the urine may worsen a tendency to stone formation, which will lead to a higher incidence of bilateral calculi.
D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications; D007669:Kidney Calculi / Q000139:chemically induced* / Q000150:complications; D008297:Male; D008750:Methyldopa / Q000009:adverse effects*; D008875:Middle Aged; D012189:Retrospective Studies; D014514:Ureteral Calculi / Q000139:chemically induced* / Q000150:complications
D008750:Methyldopa