title: The influence of unithiol and spironolactone on the biliary excretion of 203Hg in rat.
abstract: Rats with cannulated bile ducts were intravenously given 203HgCl2 in the dose of 120 microgram of Hg2+ per rat. Intramuscular administration of Unithiol (sodium 2,3-dimercaptopropanosulphonate) 4 and 7 h after 203Hg injection markedly increased both biliary and urinary excretion of 203Hg. In rats with Spironolactone (17-Hydroxy-7alpha-mercapto-3-oxo-17alpha-pregn-4-ene-21-carboxylic acid, gamma-lactone, acetate) pretreatment the effect of Unithiol on the biliary excretion of 203Hg was enhanced. Urinary excretion of mercury was lowest in comparison with Unithiol treated group.
mesh_terms: D000818:Animals; D001646:Bile / Q000187:drug effects / Q000378:metabolism*; D004112:Dimercaprol / Q000031:analogs & derivatives*; D004347:Drug Interactions; D005260:Female; D008628:Mercury / Q000378:metabolism*; D051381:Rats; D013148:Spironolactone / Q000494:pharmacology*; D013997:Time Factors; D014494:Unithiol / Q000494:pharmacology*
chemical_list: D004112:Dimercaprol; D013148:Spironolactone; D014494:Unithiol; D008628:Mercury