Dibenztroponeacetic and -propionic acids. Potent new antiinflammatory agents.
The syntheses and antiinflammatory assays of some dibenztroponeacetic and -propionic acids and derivatives are described. The most potent compound, d-2-(5H-dibenzo[a,d]cyclohepten-5-on-2-yl)propionic acid, has a potency of ca, 70 times phenylbutazone in the rat carrageenan paw assay and two to three times indomethacin in long-term animal assays. Some beta-dialkylaminoethyl esters of this compound also show high antiinflammatory activity.
D000085:Acetates / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis*; D001169:Arthritis, Experimental / Q000503:physiopathology; D003986:Dibenzocycloheptenes / Q000138:chemical synthesis* / Q000494:pharmacology; D004487:Edema / Q000503:physiopathology; D005260:Female; D006099:Granuloma / Q000503:physiopathology; D008297:Male; D051379:Mice; D010146:Pain / Q000503:physiopathology; D011422:Propionates / Q000138:chemical synthesis / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship
D000085:Acetates; D000893:Anti-Inflammatory Agents; D003986:Dibenzocycloheptenes; D011422:Propionates