title: Major pharmacological effects of 6-methoxytetrahydro-beta-carboline, a drug elevating the tissue 5-hydroxytryptamine level.
abstract: Major pharmacological effects of 6-methoxy-1,2,3,4-tetrahydro-beta-carboline (6-methoxytryptoline, 6-MeOTHBC) are described. It seemed to have a weak effect of its own on 5-HT-receptors. It is concluded that most of the effects, like the increase of rectal temperature after peripheral administration and decrease and then increase after intrahypothalamic application as well as the antagonism of the group toxicity of amphetamine without effect on norepinephrine toxicity or barbiturate sleeping time, can result from the increase of tissue 5-HT-concentration and/or inhibition of 5-HT-uptake.
mesh_terms: D000208:Acute Disease; D000661:Amphetamine / Q000633:toxicity; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002243:Carbolines / Q000494:pharmacology* / Q000633:toxicity; D002415:Cats; D004347:Drug Interactions; D004971:Estrus / Q000187:drug effects; D005260:Female; D007211:Indoles / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009130:Muscle, Smooth / Q000187:drug effects; D009638:Norepinephrine / Q000633:toxicity; D009929:Organ Size; D010424:Pentobarbital / Q000037:antagonists & inhibitors; D011247:Pregnancy; D051381:Rats; D012110:Reserpine / Q000494:pharmacology; D012701:Serotonin / Q000032:analysis*; D013045:Species Specificity; D013270:Stomach / Q000187:drug effects
chemical_list: D002243:Carbolines; D007211:Indoles; D012701:Serotonin; D012110:Reserpine; D000661:Amphetamine; D010424:Pentobarbital; D009638:Norepinephrine