The influence of calcium antagonists on endothelium.
Calcium antagonists possess, similarly to endothelotropic (vasotropic) drugs, a stabilizing effect on endothelium against the disrupting influence of citrate in rats. This was demonstrated with the new method for counting of circulating endothelial cells. The effect is dose related and the effective experimental dosages corresponded closely to the clinical dose range. The common link between both drug groups is probably the mediating effect of ionic calcium.
D000818:Animals; D002118:Calcium / Q000037:antagonists & inhibitors*; D002866:Chromonar / Q000494:pharmacology; D004176:Dipyridamole / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004727:Endothelium / Q000187:drug effects*; D005260:Female; D009543:Nifedipine / Q000494:pharmacology; D011299:Prenylamine / Q000494:pharmacology; D051381:Rats; D014700:Verapamil / Q000494:pharmacology
D004176:Dipyridamole; D014700:Verapamil; D009543:Nifedipine; D011299:Prenylamine; D002866:Chromonar; D002118:Calcium