Morphological effects of moderate diet and clofibrate on swine atherosclerosis.
Early proliferative coronary atherosclerosis was produced in swine by feeding them a high-fat, high-cholesterol diet for 17 months, at which time one group of animals was killed (reference group), while the remainder was transferred for 12 months to a moderate diet that resulted in serum cholesterol levels of about 190 mg/100 ml. The moderate diet only did not decrease the size of coronary lesions, but prevented their progression. The addition of clofibrate therapy caused regression that involved a significant decrease in size, gross sudanophilia, and extent of calcification and the disappearance of foam-cell lesions. Resultant serum cholesterol levels appear to be more important than the amount of dietary cholesterol in the progression, prevention, and regression of swine coronary atherosclerosis.
D000818:Animals; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D002994:Clofibrate / Q000627:therapeutic use*; D003327:Coronary Disease / Q000178:diet therapy / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*; D003331:Coronary Vessels / Q000473:pathology*; D004036:Diet, Atherogenic; D008297:Male; D012075:Remission, Spontaneous; D013552:Swine
D002791:Cholesterol, Dietary; D002994:Clofibrate