Molecular-genetic effects of cadmium chloride.
We studied the effect of cadmium chloride on: (1) the DNA of human cells; (2) the mutagenic effect of reproducing Kilham virus; (3) the synthesis of virus-induced interferon, and (4) the reproduction of oncogenic (mammalian leucosis) virus. Cadmium chloride caused degradation of DNA in human- and rat-embryo cells. Culture infected by the virus in the presence of cadmium sulphate had the highest yield of cells with chromosomal aberrations. Cadmium chloride caused marked inhibition of the virus-induced synthesis of interferon. The introduction of cadmium chloride into diploid cells infected by the leucosis virus caused a 3-4 fold increase in the yield of virus-induced transformation foci.
D002104:Cadmium / Q000494:pharmacology*; D002460:Cell Line; D002712:Chlorides / Q000494:pharmacology; D002869:Chromosome Aberrations; D004247:DNA / Q000378:metabolism*; D006801:Humans; D007372:Interferons / Q000096:biosynthesis*; D009154:Mutation; D012190:Retroviridae / Q000187:drug effects; D014779:Virus Replication
D002712:Chlorides; D002104:Cadmium; D004247:DNA; D007372:Interferons