title: Pharmacokinetic aspects of digoxin in patients with terminal renal failure III. Effect of heparin.
abstract: The effect of an i.v. injection of 25 mg heparin on the plasma digoxin level was studied in ten patients on chronic intermittent hemodialysis. Six patients did not show a significant change in the plasma digoxin level of more than 0.1 ng/ml. An increase up to 0.4 ng/ml was observed in four patients. The consequences with regard to digoxin assay and clinical effects are discussed.
mesh_terms: D004077:Digoxin / Q000097:blood*; D004347:Drug Interactions; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006493:Heparin / Q000097:blood / Q000494:pharmacology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood*; D007700:Kinetics; D014280:Triglycerides / Q000097:blood
chemical_list: D005230:Fatty Acids, Nonesterified; D014280:Triglycerides; D004077:Digoxin; D006493:Heparin