title: [Chromosome studies before and after phenylbutazone infusion therapy].
abstract: Studies on chromosomes of lymphocyte cultures of peripheral blood were performed in 15 patients with rheumatoid arthritis (group I: 48-h culture, n = 8; group II; 72-h culture, n = 7) before and after phenylbutazone infusion therapy (600 mg/d for 10 days). The average rate of cells with exchange aberrations of chromosomal type after this therapy (group I: 0.52%; group II: 0.69%) was higher than the control values found before treatment (group I: 0.13%; group II: 0%); X2 test: group I + II: P less than 0.025. The results obtained are discussed.
mesh_terms: D000328:Adult; D000368:Aged; D002875:Chromosomes / Q000187:drug effects*; D006801:Humans; D007263:Infusions, Parenteral; D008214:Lymphocytes / Q000187:drug effects / Q000648:ultrastructure*; D008875:Middle Aged; D010653:Phenylbutazone / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D010653:Phenylbutazone
vernacular_title: Chromosomenuntersuchungen vor und nach Infusionstherapie mit Phenylbutazon.