Effects of the nonapeptide SQ 20.881 on the blood pressure of conscious normotensive and chronic hypertensive mice.
Prevention of conversion of angiotensin I to angiotensin II by means of a converting enzyme inhibitor, the nonapeptide SQ 20.881, in chronic hypertensive mice was followed by a drop in blood pressure in all mice independent of the ethiology of hypertension; in conscious normotensive mice was observed a significant decrease in blood pressure, which, however, was less than that observed in the hypertensive mice.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002908:Chronic Disease; D006977:Hypertension, Renal / Q000188:drug therapy / Q000503:physiopathology*; D051379:Mice; D009842:Oligopeptides / Q000494:pharmacology*; D013722:Teprotide / Q000494:pharmacology* / Q000627:therapeutic use
D009842:Oligopeptides; D013722:Teprotide