[Studies of sulfhemoglobin formation by various drugs (3) (author's transl)].
Sulfhemoglobin (SHb) and methemoglobin (MHb) formations by various compounds were examined by single and three consecutive intraperitoneal administrations to mice. With a single administration, methemoglobinemia was induced by diphenylamine (DPA), 1-naphthylamine (NA), phenylnaphthylamine (PNA), N-(1-naphthyl) anthranilic acid (N1) and N-(1'-naphthyl)-2-aminophenylacetic acid (IG240), and was not observed with phenylanthranilic acid (PAA), N-benzoyl-N'-phenyl-2, 6-diaminobenzoic acid (BPAA), flufenamic acid (FA), mefenamic acid (MFA), N-(2-6-dichlorophenyl) anthranilic acid (CPAA), N-(2', 6'-dichlorophenyl)-2-aminophenylacetic acid (CPPA), nine derivatives of N1 and two derivatives of IG240. On the other hand, sulfhemoglobinemia, with a single administration, was found to be induced by NA. Furthermore, with three consecutive administrations, such was induced by DPA, PAA, BPAA and FA even though SHb was not demonstrated with a single administration, and was not observed with MF, CPAA, CPPA and various derivatives of N1 and IG240.
D015057:1-Naphthylamine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D000814:Aniline Compounds / Q000494:pharmacology*; D000818:Animals; D004159:Diphenylamine / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008706:Methemoglobin / Q000096:biosynthesis; D051379:Mice; D009281:Naphthalenes / Q000031:analogs & derivatives*; D010648:Phenylacetates / Q000008:administration & dosage / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013435:Sulfhemoglobin / Q000096:biosynthesis*; D013997:Time Factors; D062367:ortho-Aminobenzoates / Q000008:administration & dosage / Q000494:pharmacology*
D000814:Aniline Compounds; D009281:Naphthalenes; D010648:Phenylacetates; D062367:ortho-Aminobenzoates; D008706:Methemoglobin; D013435:Sulfhemoglobin; D015057:1-Naphthylamine; D004159:Diphenylamine