Evaluation of a charcoal-sorbitol mixture as an antidote for oral aspirin overdose.
The preparation of charcoal in a 70% sorbitol solution results in a suspension that is more palatable and less gritty than an aqueous slurry of charcoal. Although the charcoal-sorbitol mixture may be slightly less effective in reducing the extent of aspirin absorption compared with a charcoal slurry, it may prove to be of particular value in those cases where acceptance of a charcoal slurry presents a problem.
D000328:Adult; D000931:Antidotes / Q000008:administration & dosage / Q000627:therapeutic use*; D001241:Aspirin / Q000378:metabolism / Q000506:poisoning*; D002606:Charcoal / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D004341:Drug Evaluation; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D008297:Male; D013012:Sorbitol / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D013535:Suspensions
D000931:Antidotes; D013535:Suspensions; D002606:Charcoal; D013012:Sorbitol; D001241:Aspirin