title: [Carcinogenic properties of diaphene NN].
abstract: Carcinogenic activity of diaphene NN was studied in female mice of line CC57W. Weekly subcutaneous injections of 40 mg of diaphene induced tumors in 65% of mice (leucoses and local sarcomas). Instillations of 40 mg of diaphene per os (3-5 times per week) induced tumors in 39% of mice. In control mice tumors were found in 38% of cases, including 36% of leucoses. It is concluded that diaphene NN shows an insignificant carcinogenic activity.
mesh_terms: D000818:Animals; D002273:Carcinogens; D005260:Female; D007942:Leukemia, Experimental / Q000139:chemically induced; D051379:Mice; D008810:Mice, Inbred C57BL; D009281:Naphthalenes / Q000008:administration & dosage / Q000494:pharmacology; D009374:Neoplasms, Experimental / Q000139:chemically induced; D010655:Phenylenediamines / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D002273:Carcinogens; D009281:Naphthalenes; D010655:Phenylenediamines
vernacular_title: O kantaserogennykh svoĭstvakh diafena NN.