title: Mood change and magnesium. A possible interaction between magnesium and lithium?
abstract: Magnesium and lithium are chemically related. Magnesium is an essential ion in many enzyme systems and lithium is of value in the treatment of manic-depressive disease. A significant sex difference in mean plasma magnesium levels is reported in 44 depressed patients. It is suggested that further studies of magnesium metabolism are indicated and that they may provide a better understanding of manic-depressive disease and the mode of action of lithium.
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000188:drug therapy; D003863:Depression / Q000097:blood*; D005260:Female; D006801:Humans; D008094:Lithium / Q000494:pharmacology; D008274:Magnesium / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012737:Sex Factors
chemical_list: D008094:Lithium; D008274:Magnesium