title: [Experimental studies on topic application of amikacin to the eye (author's transl)].
abstract: The compatibility of amikacin as well as its penetration into the different tissues of the eye were studied experimentally in rabbits. Amikacin is well tolerated, both when applying drops and subonjunctival injections. When 1% solution of amikacin is dropped into the eye, antibacterially effective concentrations are achieved in the cornea and in the aqueous humour. There was only minimum penetration in the cornea found after subconjunctival injection. No amikacin was found in the vitreous body, neither when applying drops nor subconjuctival injections.
mesh_terms: D000287:Administration, Topical; D000583:Amikacin / Q000008:administration & dosage / Q000009:adverse effects* / Q000378:metabolism; D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism; D003228:Conjunctiva; D003315:Cornea / Q000378:metabolism; D005123:Eye / Q000187:drug effects*; D007267:Injections; D007612:Kanamycin / Q000031:analogs & derivatives*; D009883:Ophthalmic Solutions; D011817:Rabbits
chemical_list: D009883:Ophthalmic Solutions; D007612:Kanamycin; D000583:Amikacin
vernacular_title: Experimentelle Untersuchungen zur lokalen Anwendung von Amikacin am Auge.