title: HLA antigens in autoimmune thyroid diseases.
abstract: HLA antigens were determined in 85 unrelated Japanese patients with Graves' disease and 56 patients with Hashimoto's thyroiditis, with the use of the microcytotoxicity test. HLA-Bw35 was found in 36.4% of 85 patients with Graves' disease compared with 13.3% of 150 normal control subjects. This difference in antigen frequency is significant at the level of P less than .0005. The association with HLA-Bw35 in Japanese patients with Graves' diseases is different from that with HLA-B8 in white patients. In patients with Hashimoto's thyroiditis, HLA-Bw35 was also increased (28.5% of 56 patients) but not at a level of statistical significance (P less than .05).
mesh_terms: D000328:Adult; D005260:Female; D006111:Graves Disease / Q000276:immunology*; D006680:HLA Antigens; D006801:Humans; D008297:Male; D013967:Thyroiditis, Autoimmune / Q000276:immunology*
chemical_list: D006680:HLA Antigens