[Penetration of a non-steroidal anti-inflammatory drug into human skin in vitro and in vivo. Tissue concentrations and flow rates of p-butoxyphenylacetohydroxamic acid (author's transl)].
The penetration of p-butoxyphenylacetohydroxamic acid (BPHS; Parfenac) from a crean and an ointment into human skin in vivo and in vitro was investigated. From both preparation forms high tissue concentrations were achieved. Flow rates through the horny layer could be calculated, that from the ointment being considerably higher (3.8 . 10(-8) mol/cm2 . h) than that from the cream (7 . 10(-9) mol/cm2 . h). A control experiment in vivo proved that the in vitro data are relevant. The difference between dermal concentrations in vitro (with abolished capillary function) and that in vitro (with capillary system functioning) reflected the fast absorption of the drug by the vessels.
D000287:Administration, Topical; D000893:Anti-Inflammatory Agents / Q000378:metabolism*; D002019:Bufexamac / Q000378:metabolism*; D002196:Capillaries; D006801:Humans; D006877:Hydroxamic Acids / Q000378:metabolism*; D066298:In Vitro Techniques; D012867:Skin / Q000098:blood supply; D012869:Skin Absorption
D000893:Anti-Inflammatory Agents; D006877:Hydroxamic Acids; D002019:Bufexamac
Penetration eines nicht steroidalen Antiphlogistikums in die menschliche Haut in vitro und in vivo. Gewebskonzentrationen und Flussraten von p-Butoxyphenylacetohydroxamsäure.