[Effects of 6-methyl-uracil upon the phagocytic activity in mice following whole-body X-irradiation OR 2,4,6-triethyleneimino-s-triazine treatment (author's transl)].
1. Phagocytic activity measured by means of the intravasal clearance of a soot dispersion in male NMRI-mice was increased six to ten days after whole-body X-irradiation (640 R) and decreased during the same period after i.v. administration of 2,4,6-triethyleneimino-s-triazine (TEM 2.0 mg/kg). 2. By means of 6-methyl-uracil food admixtures (200 to 400 ppm during 2 or 3 weeks) or by repeated intravenous injections of a N-methyl-D-glucosamine-6-methyluracil complex (62.5 to 250 mg/kg daily during five days), a significant augmentation of the phagocytic index being related to time and dosage was obtained in otherwise untreated mice. Comparable results were seen using cytidine and cytidine-s'-phosphate, whereas guanosine-5'-phosphate remained ineffective. 3. Whilst stimulating effects of 6-methyl-uracil or its N-methyl-D-glucosamine complex on X-irradiated mice were suspended, an increase up to supernormal values of the phagocytic index was produced by the pyrimidine base in animals treated with TEM. In accordance to this the survival rate of lethally X-irradiated mice (960 R) could not be increased; with animals given lethal TEM-doses, however, a significantly increased survival rate was obtained. 4. The present investigations as well as former biochemical analyses confirm the assumption that 6-methyluracil produces its regeneration effects, to some extent at least, by specific pathways influencing the reticuloendothelium. Different results from X-irradiated and TEM-treated mice are referring to the different points of attack of the two noxa.
D000818:Animals; D002470:Cell Survival / Q000528:radiation effects; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010587:Phagocytosis / Q000187:drug effects* / Q000528:radiation effects; D011829:Radiation Dosage; D014227:Triazines / Q000494:pharmacology*; D014498:Uracil / Q000494:pharmacology*
D014227:Triazines; D014498:Uracil
Zur Wirkung von 6-Methyluracil auf die Phagozytoseaktivität von Mäusen nach Einwirkung von Ganzkörper-Röntgenbestrahlung oder 2,4,6-Triäthylenimino-s-triazin.