[Examination of psychic effects of a new analgesic agent of the cyclohexanols series. A contribution to a possible psychic dependence potential of tramadol (author's transl)].
A double-blind trial was performed with 30 male students of the University of Düsseldorf. The volunteers were divided at random into two groups containing 15 subjects each. One group received 1-(m-methoxyphenyl)-2-(dimethylaminomethyl)-cyclohexan-1-ol (tramadol; Tramal), and the other placebo. The latter served as the controls. On three occasions at regular intervals in the course of one week the volunteers were questioned on the basis of Janke and Debus's "Eigenschaftswörterliste" (EWL) (attribution word list). The interviews were carried out 1 h after the injection (1 ampoule 100 mg i.m.). The results in the sense of any euphoretic or dysphoretic effects are discussed.
D000328:Adult; D000700:Analgesics / Q000494:pharmacology*; D003511:Cyclohexanols / Q000494:pharmacology*; D004311:Double-Blind Method; D005059:Euphoria / Q000187:drug effects; D006801:Humans; D008297:Male; D010919:Placebos; D019966:Substance-Related Disorders / Q000209:etiology*; D013997:Time Factors
D000700:Analgesics; D003511:Cyclohexanols; D010919:Placebos
Psychologische Wirkungsprüfung eines neuen Analgetikums aus der Cyclohexanol-Reihe. Ein Beitrag zur Abklärung des psychischen Abhängigkeitspotentials von Tramadol.