Autoradiographic distribution study of 14C-2-phenyl-6-sulfonamido-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone (fenquizone) in mice.
The distribution of 2-phenyl-6-sulfonamido-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone (fenquizone, M.G. 13054) labelled with 14C in mice was studied by means of an autoradiographic technique. High concentration of radioactivity was found in the intestine, liver, kidney, blood, myocardium and skeletal muscles in decreasing order at various times after oral administration. The drug was easily absorbed in the intestine reaching the highest concentration between 2 and 4 hr. The labelled compound did not cross the blood-brain barrier.
D000818:Animals; D001345:Autoradiography; D002319:Cardiovascular System / Q000378:metabolism; D002490:Central Nervous System / Q000378:metabolism; D004064:Digestive System / Q000378:metabolism; D004232:Diuretics / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D009132:Muscles / Q000378:metabolism; D011799:Quinazolines / Q000378:metabolism*; D013449:Sulfonamides; D013997:Time Factors; D014018:Tissue Distribution; D014566:Urogenital System / Q000378:metabolism
D004232:Diuretics; D011799:Quinazolines; D013449:Sulfonamides