[Effect of GABA and phenybut on the neuronal activity of the cortex and potentials of the spinal roots].
The effects of GABA AND PHENYBUT (BEta-phenyl-gamma-aminobutyric acid) on the dorsal (DRP) and ventral (VPR) root potentials were studied in the isolated frog spinal cord. The direct action of these agents on the neuronal membranes was studied by means of the microiontophoretic method in the cat cerebral cortex. Phenybut, like GABA, SUPPRESSES DRP and VRP at the spinal cord level, but it prolongs the duration of DRP and VRP rising phase and at the same time depresses the VR reflexes. Phenybut microiontophoretic application does not considerably affect the neuronal activity whereas GABA exerts an obvious inhibitory action. Differences in the mechanisms of GABA and phenybut actions on the c. n. s. elements are discussed.
D000613:Aminobutyrates / Q000494:pharmacology*; D000818:Animals; D001001:Anura; D002415:Cats; D004594:Electrophysiology; D009044:Motor Cortex / Q000187:drug effects*; D009475:Neurons, Afferent / Q000187:drug effects; D009476:Neurons, Efferent / Q000187:drug effects; D011898:Ranidae; D011930:Reaction Time / Q000187:drug effects; D012018:Reflex / Q000187:drug effects; D013003:Somatosensory Cortex / Q000187:drug effects*; D013126:Spinal Nerve Roots / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D000613:Aminobutyrates; D005680:gamma-Aminobutyric Acid
Vliianie GAMK i fenibuta na neĭronnuiu aktivnost' kory i potentsialy koreshkov spinnogo mozga.