The influence of D-penicillamine on cell proliferation. I. Quantitative investigations during an acute exudative inflammation in a model granuloma.
The influence of D-penicillamine (DPA) administration on a defined acute exudative inflammation in a model granuloma was investigated in a short-term experiment. The results indicate that DPA administration influences the metabolism of collagen but does not influence the proliferation behaviour of the fibroblasts. A significant increase in the number of fibroblasts can be explained in terms of an interaction of the loss of the soluble collagen with the number of fibroblasts necessary to maintain the total collagen level constant.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects*; D003094:Collagen / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D005122:Exudates and Transudates / Q000166:cytology; D005347:Fibroblasts / Q000378:metabolism; D007249:Inflammation / Q000378:metabolism / Q000473:pathology*; D008297:Male; D010396:Penicillamine / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D003094:Collagen; D004247:DNA; D010396:Penicillamine