Significance of Hageman factor (coagulation factor XII) for neutrophil locomotion and chemotaxis.
Neutrophils separated from Hageman factor-deficient blood exhibit normal random and directional locomotion. No defect in cytotaxin formation could be demonstrated in Hageman factor-deficient plasma, nor did kallikrein inhibitor interfere with the chemotactic activity of normal immune complex-activated human plasma. The results suggest that the chemotactic activity which is detectable in unfractionated human plasma is not derived from Hageman factor-dependent pathways.
D000936:Antigen-Antibody Complex; D002465:Cell Movement; D002634:Chemotaxis, Leukocyte; D005174:Factor XII; D005175:Factor XII Deficiency / Q000276:immunology; D006801:Humans; D007610:Kallikreins / Q000096:biosynthesis; D007616:Kaolin / Q000494:pharmacology; D009504:Neutrophils / Q000276:immunology*; D010960:Plasminogen Activators / Q000096:biosynthesis
D000936:Antigen-Antibody Complex; D007616:Kaolin; D005174:Factor XII; D007610:Kallikreins; D010960:Plasminogen Activators