The effects of a deproteinized blood extract on the myocardial changes developing during experimentally induced intermittent hypoxia.
Myocardial hypoxia induced by intermittent cross-clamping of the aorto-coronary bypass during closed-heart surgery provokes progressive derangement of the myocardial metabolism. The principal changes observed after 18 min of hypoxia (without protection) were a marked swelling of mitochondria, distortion of cristae, reduction in glycogen content, interstitial oedema, focal destruction of I-band material and coagulation necrosis of myofilaments. Another characteristic change is the decoupling of oxidative phosphorylation. These morphological and biochemical changes were successfully prevented by the administration of Solcoseryl (Actihaemyl), a dialysis concentrate from deproteinised calf blood. The less pronounced structural and functional mitochondrial changes in protected hearts suggest that the myocardium is able to tolerate a more severe hypoxia under Solcoseryl protection.
D000818:Animals; D001790:Blood Physiological Phenomena; D003327:Coronary Disease / Q000378:metabolism / Q000473:pathology*; D004285:Dogs; D008929:Mitochondria, Heart / Q000187:drug effects; D009206:Myocardium / Q000648:ultrastructure; D010085:Oxidative Phosphorylation / Q000187:drug effects; D013997:Time Factors; D014020:Tissue Extracts / Q000494:pharmacology*
D014020:Tissue Extracts