title: [Pharmacological effects of the new psychotropic preparation, mebikar].
abstract: By its effects mebicar -- a derivative of bicyclic bis-ureas -- may be refered to psychotropic drugs occupying a middle position between tranquilizers and neuroleptics. The drug inhibits the orientation reaction in albino mice, potentiates the action of narcotic hypnotics, abolishes the conditioned reflex reaction of avoidance, displays central adrenolytic activity, interferes with the norepinephrine metabolism in the brain stem and modifies the permeability of the blood-encephalic barrier, like this is done by the known neuroleptics. The substance is little toxic, does not exert any direct spasmolytic action on the isolated organs.
mesh_terms: D000661:Amphetamine / Q000037:antagonists & inhibitors; D000818:Animals; D001736:Biureas / Q000494:pharmacology* / Q000633:toxicity; D001812:Blood-Brain Barrier / Q000187:drug effects; D001643:Bridged Bicyclo Compounds / Q000494:pharmacology* / Q000633:toxicity; D001952:Bridged-Ring Compounds / Q000494:pharmacology*; D002490:Central Nervous System / Q000187:drug effects; D002697:Chloral Hydrate / Q000494:pharmacology; D003214:Conditioning, Classical / Q000187:drug effects; D003292:Convulsants / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006591:Hexobarbital / Q000494:pharmacology; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009068:Movement / Q000187:drug effects; D011619:Psychotropic Drugs; D011817:Rabbits; D051381:Rats; D013997:Time Factors
chemical_list: D001736:Biureas; D001643:Bridged Bicyclo Compounds; D001952:Bridged-Ring Compounds; D003292:Convulsants; D011619:Psychotropic Drugs; C015979:mebikar; D002697:Chloral Hydrate; D006591:Hexobarbital; D000661:Amphetamine
vernacular_title: Farmakologicheskie éffekty novogo psikhotropnogo preparata mebikara.