title: Disseminated tuberculosis, bone marrow necrosis and lymphoma: a case report.
abstract: Tuberculosis often complicates lymphoma, and bone marrow necrosis has been described in disseminated tuberculosis. However, the association of lymphoma, disseminated tuberculosis and bone marrow necrosis is rare. We report a patient with this triple association. After a 3-week influenza-like illness the patient was admitted to hospital semicomatose with pancytopenia and hyponatraemia. During routine examination a bone marrow trephine biopsy revealed diffuse lymphomatous infiltration with scattered necrotic foci. On Ziehl-Neelsen staining these foci exhibited numerous acid-fast bacilli. The patient subsequently died and at autopsy was found to have widely disseminated non-reactive tuberculosis.
mesh_terms: D000328:Adult; D001853:Bone Marrow / Q000473:pathology; D001855:Bone Marrow Diseases / Q000150:complications* / Q000473:pathology; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000150:complications* / Q000473:pathology; D008297:Male; D009336:Necrosis / Q000150:complications*; D014391:Tuberculosis, Miliary / Q000150:complications* / Q000473:pathology