[Chromatographic separation of racemic thalidomide and teratogenic activity of its enantiomers (author's transl)].
Racemic thalidomide is chromatographically separated on optically active polyamide giving both enantiomers. After i.p. administration only the S-(-)-enantiomer is teratogenic on SWS mice and Natal rats.
D000818:Animals; D002845:Chromatography; D004622:Embryo, Mammalian / Q000187:drug effects; D005260:Female; D007928:Lethal Dose 50; D051379:Mice; D008813:Mice, Inbred ICR; D011247:Pregnancy; D051381:Rats; D013237:Stereoisomerism; D013723:Teratogens; D013792:Thalidomide / Q000302:isolation & purification* / Q000633:toxicity
D013723:Teratogens; D013792:Thalidomide
Chromatographische Racemattrennung von Thalidomid und teratogene Wirkung der Enantiomere.