title: The aminoglycoside antibiotics. I. Synthesis and biological evaluation of an analog of gentamicin.
abstract: The synthesis of 2-deoxy-4-O-(2,6-diamino-2,3,4,6-tetradeoxy-alpha-D-erythrohexopyranosyl)-6-O-(3-deoxy-3-methylamino-alpha-D-xylopyranosyl)-D-streptamine (1), an analog of gentamicin A, from diideoxyneamine and methyl 3-methylamino-3-deoxy-beta-D-xylopyranoside is described. The product was characterized by its 13C nmr spectrum and was found to exhibit broad spectrum antibacterial activity.
mesh_terms: D001419:Bacteria / Q000187:drug effects; D005839:Gentamicins / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D005839:Gentamicins