[Changes in the oxidative glucose brain metabolism under long-term xantinol-nicotinate medication (author's transl)].
8 patients suffering from dementia were treated with xantinol-nicotinate for 4 weeks. At the beginning and at the end of the treatment cerebral blood flow and cerebral metabolic rates of oxygen, glucose and lactate were measured with the N2O-method. With regard to the initial level of each parameter CBF, CMR glucose and CMR oxygen increased significantly, if it had been decreased at the first measurement, while primarily normal or even increased parameters did not change. Seming contradictions to other authors are discussed.
D001921:Brain / Q000378:metabolism*; D002560:Cerebrovascular Circulation / Q000187:drug effects; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007773:Lactates / Q000378:metabolism; D001523:Mental Disorders / Q000188:drug therapy; D010084:Oxidation-Reduction; D010101:Oxygen Consumption / Q000187:drug effects; D013806:Theophylline / Q000031:analogs & derivatives*; D014971:Xanthinol Niacinate / Q000009:adverse effects* / Q000627:therapeutic use
D007773:Lactates; D014971:Xanthinol Niacinate; D013806:Theophylline; D005947:Glucose
Die Veränderung des oxidativen Glukosestoffwechsels des Gehirns unter langfristiger Xantinol-nicotinat-Medikation.