Mechanism of relaxant action of prostaglandin F2alpha on the guinea-pig isolated trachea.
Prostaglandin F2alpha consistently produced a dose-related triphasic response in guinea-pig isolated tracheal chain preparations. The response consisted of an initial transient contraction followed by a transient relaxation, followed by a further contraction. The relaxant action was not due to adrenergic or histaminergic transmission, but might be due to a PG-like material released by the PGF 2alpha-induced contraction.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D006168:Guinea Pigs; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009126:Muscle Relaxation / Q000187:drug effects*; D011460:Prostaglandins F / Q000008:administration & dosage / Q000494:pharmacology*; D014132:Trachea / Q000187:drug effects*
D011460:Prostaglandins F