title: Effect of roentgen, cyclotron neutron, or mixed neutron-photon fractionated irradiation of mice. LD50/4 day values.
abstract: Mice were whole-body-irradiated with 5 fractions of roentgen rays in 5 days, 5 fractions of cyclotron neutrons in 5 days, or with mixed neutron-photon fractionated radiation, in the sequence n-n-x-x-x or n-x-x-x-n. The LD50/4 day values were determined. Roentgen rays and neutrons interact in the additive manner in the mixed fractionation schemes: effective dose per fraction is as predicted from the roentgen ray-only and neutron-only experiments. This essentially agrees with HENDRY et coll. (1976). However, no trend was found towards a less-than -additive effect which was observed by those authors and has also been suggested in skin response to mixed schemes (NELSON et coll. 1975).
mesh_terms: D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005260:Female; D007422:Intestines / Q000528:radiation effects; D007928:Lethal Dose 50; D051379:Mice; D009374:Neoplasms, Experimental / Q000532:radiotherapy; D009502:Neutrons; D010315:Particle Accelerators; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental; D012867:Skin / Q000528:radiation effects; D014965:X-Rays