Bile flow and biliary excretion rate of some organic anions in phenobarbital-pretreated rats.
Bile flow and the biliary excretion of indocyanine green, bromcresol green, eosine, bromsulphthalein-glutathione conjugate (BSP-GSH), amaranth and iodoxamic acid were investigated in control and phenobarbital-pretreated rats (75 mg/kg i.p. daily for 5 days). The bile flow was increased by phenobarbital from an average of 50.6 to 77.7 microliter/kg/min. Depending on the dose, the biliary excretion rate of bromcresol green was increased by 48-496% and that of eosine by 30-149%. After phenobarbital pretreatment the excretion of BSP-GSH was also enhanced by 34-52%, that of amaranth by 37-53% and that of iodoxamic acid by 40-56%. However, the biliary excretion of indocyanine green remained unchanged. There was no parallelism between the increase in bile flow and biliary excretion of the drugs.
D000548:Amaranth Dye / Q000378:metabolism; D000818:Animals; D000838:Anions; D001646:Bile / Q000032:analysis / Q000378:metabolism*; D001711:Biotransformation / Q000187:drug effects*; D001961:Bromcresol Green / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D007208:Indocyanine Green / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D010634:Phenobarbital / Q000494:pharmacology*; D051381:Rats; D013448:Sulfobromophthalein / Q000378:metabolism; D014283:Triiodobenzoic Acids / Q000378:metabolism
D000838:Anions; D014283:Triiodobenzoic Acids; D013448:Sulfobromophthalein; D001961:Bromcresol Green; D000548:Amaranth Dye; D005978:Glutathione; D007208:Indocyanine Green; D010634:Phenobarbital