title: [The secretory action of various C-5-alkylsubstituted histamines and N alpha-methyl-histamines on anaesthetized cats with Heidenhain pouches (author's transl)].
abstract: In particular, the action of N alpha-methyl-histamine has to be considered since its secretory response is approximately 1.5 times greater than that of histamine and its secretion lasted for a longer period of time. After C-5-alkylsubstitution, both 5-methyl-histamine and N alpha,5-dimethyl-histamine showed secretory action comparable to that of histamine; the agonistic activity, however, decreased with increasing chain length.
mesh_terms: D000818:Animals; D002415:Cats; D005750:Gastric Juice / Q000378:metabolism*; D006632:Histamine / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D008761:Methylhistamines / Q000494:pharmacology*; D013268:Stimulation, Chemical; D013329:Structure-Activity Relationship; D013997:Time Factors
chemical_list: D008761:Methylhistamines; D006632:Histamine
vernacular_title: Uber die Wirkung von 5-alkylsubstituierten Histaminen und N alpha-Methyl-histaminen auf die Magensekretion der narkotisierten Heidenhain-Katze.