[Acylaminoalkyl substituted benzoic and phenylalkane acids with hypoglycaemic properties (author's transl)].
Newly developed carbonic acids with hypoglycaemic properties are presented. Their activity is based on an insulin secretion with unusual biphasic dynamics which is seen both after enteral and parenteral administration. In vitro, the substances described have an inhibitory effect on gluconeogenesis in the liver and lipolysis in adipose tissue.
D000818:Animals; D001565:Benzoates / Q000138:chemical synthesis* / Q000494:pharmacology; D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000138:chemical synthesis*; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D011817:Rabbits; D051381:Rats
D001565:Benzoates; D002264:Carboxylic Acids; D007004:Hypoglycemic Agents; D007328:Insulin
Acylaminoalkyl-substituierte Benzoe- und Phenylalkansäuren mit blutglukose-senkender Wirkung. Kurze Mitteilung.