title: Anticoccidial derivatives of 6-azauracil. 2. High potency and long plasma life of N1-phenyl structures.
abstract: Attachment of substituted phenyl side chains at N1 of 6-azauracil caused striking increases in plasma life and anticoccidial potency. The increases were related in part to the acidity of the imide hydrogen. Maximum effects were shown by phenyl rings substituted in both meta positions by compact, electron-withdrawing, lipophilic substituents, as in 1-(3',5'-dichlorophenyl)-6-azauracil, which had plasma half-life of 160 h and a potency 250-fold greater than that of 6-azauracil.
mesh_terms: D000818:Animals; D002645:Chickens; D003048:Coccidiosis / Q000188:drug therapy; D003049:Coccidiostats / Q000138:chemical synthesis*; D006207:Half-Life; D008297:Male; D013329:Structure-Activity Relationship; D014498:Uracil / Q000031:analogs & derivatives* / Q000097:blood / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D003049:Coccidiostats; D014498:Uracil; C100248:azauracil