title: Contact sites between lymphoid cells of the bursa of Fabricius, in vivo and in vitro.
abstract: Contact sites between lymphocytes and between lymphocytes and macrophages were demonstrated by electron microscopy in the lymphoid follicles of the bursa of Fabricius. When compared with nonspecialized regions of the cell membranes, these contact sites were characterized by a decreased intercellular distance, subplasmalemmal densities and coated pits. Microfilaments, microtubules and coated vesicles of the subjacent cytoplasm were frequently associated with these contact sites. When the same cells were isolated and introduced into culture, they formed cluster-like assemblies in which cells were closely approximated along broadly contacting surfaces. The morphology of the sites appeared to involve primarily the plasma membrane (including coated pits) and the cell coat. These observations indicated that the same cells of a given lymphoid tissue can form one type of contact site in vivo and another, dissimilar type of contact site, in vitro.
mesh_terms: D000818:Animals; D002060:Bursa of Fabricius / Q000648:ultrastructure*; D002478:Cells, Cultured; D002645:Chickens; D007365:Intercellular Junctions / Q000648:ultrastructure*; D008870:Microtubules / Q000648:ultrastructure; D013950:Thymus Gland / Q000648:ultrastructure