Modifying effect of bradykinin on motor activity in the guinea-pig gall bladder.
1. The interaction of bradykinin and cholecystokinin preparations was investigated on the guinea-pig isolated gall bladder. Bradykinin (1-100 ng/ml) induced dose-dependent contractile effects which were considerably smaller than those produced by cholecystokinin octapeptide. Bradykinin in a low concentration (1.0 ng/ml) caused a significant increase of the contraction induced by cholecystokinin octapeptide (P less than 0.001) and natural cholecystokinin-pancreozymin (P less than 0.01), and also augmented the effects of acetylcholine on this preparation. Therefore these effects are probably not specific for cholecystokinin.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001920:Bradykinin / Q000494:pharmacology*; D002766:Cholecystokinin / Q000494:pharmacology; D005704:Gallbladder / Q000187:drug effects*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*
D002766:Cholecystokinin; D000109:Acetylcholine; D001920:Bradykinin