[Relative bioavailability of a vincamine retard formulation. Pharmacokinetic study in normal subjects (author's transl)].
The study was carried out in 6 healthy volunteers in cross-over design. The pharmacokinetic parameters were calculated after application of 60 mg vincamine base in comparison to a sustained release formulation (vincamine ratio-pharm 30 mg) on the basis of a GC method. Summarizing it can be stated that the sustained release formulation has a flatter profile and is therefore more adapted to clinical application. The extent of absorption expressed as AUC of the serum concentration-time curve, has three times the extent of the curve with the pure substance.
D001682:Biological Availability; D003692:Delayed-Action Preparations; D006801:Humans; D007700:Kinetics; D008875:Middle Aged; D013997:Time Factors; D014748:Vinca Alkaloids / Q000378:metabolism*; D014749:Vincamine / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*
D003692:Delayed-Action Preparations; D014748:Vinca Alkaloids; D014749:Vincamine
Relative Bioverfürgbarkeit einer Vincamin-Retard-Zubereitung. Pharmakokinetische Untersuchungen an gesunden Versuchspersonen.