title: Comparative morphological and cytogenetical investigations on human ovarian granulosa cell tumors.
abstract: Comparative morphological and cytogenetical investigations of three granulosa cell tumors revealed the existence of two distinct categories which represent two morphocytogenetical stages of tumor progression. The following peculiarities characterized them: 1) In the premalignant stage the microfollicular and macrofollicular patterns with Call-Exner body like structures are prevailing and besides normal diploid metaphases some neardiploid are found. 2) In the malignant stage following the occurence and gradual selection of a neartriploid neoplastic cell type undifferentiated sarcomatous aspects are dominant.
mesh_terms: D046508:Culture Techniques; D005260:Female; D006106:Granulosa Cell Tumor / Q000473:pathology*; D006801:Humans; D008677:Metaphase; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000473:pathology*; D011003:Ploidies