[Circadian-induced change in the pharmacokinetic pattern exemplified on hexobarbital/Retrospective analysis of experimental data (author's transl)].
The present study dealt with data from a study to evaluate circadian influences on the pharmacokinetics of hexobarbital. It could be seen that the pharmacokinetic model changes from an open one-compartment model to an open two-compartment model in dependence of the time of application. The curve fitting to an open two-compartment model reached high correlations when the test substance was applied at 18 h. The pharmacokinetic parameters to be evaluated did not fit to literature data. After application of the substance at 10 h in the morning the curve fitting to an open one-compartment model correlated highly. The pharmacokinetic parameters at this time comparable with the known literature.
D002940:Circadian Rhythm; D006591:Hexobarbital / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D013997:Time Factors
D006591:Hexobarbital
Zirkadian bedingter Wechsel des pharmakokinetischen Modells am Beispiel von Hexobarbital. Retrospektive Analyse von Versuchsdaten.