[Determination of the thyroglobulin content in malignant and benign thyroid gland tumors as well as in thyrotoxic strumas using an immunological method].
A decreased content of the organospecific antigen (thyroglobulin) was found in the tissues of 70% of thyroid gland cancers and in about 50% of thyroid benign tumours and thyrotoxic goiters studied. These data testify to the fact that the antigenic simplification is not an obligatory and specific process for the malignant transformation of thyroid tissue. Among the neoplasms with decreased thyroglobulin content there were found tumours built up both of "A" and "C" cellular types, thus indicating the dual nature of the antigenic simplification of the thyroid tumours.
D000951:Antigens, Neoplasm / Q000032:analysis; D006042:Goiter / Q000378:metabolism*; D006044:Goiter, Nodular / Q000378:metabolism; D006801:Humans; D006980:Hyperthyroidism / Q000378:metabolism*; D007106:Immune Sera / Q000302:isolation & purification; D011233:Precipitin Tests / Q000379:methods*; D013954:Thyroglobulin / Q000032:analysis*; D013964:Thyroid Neoplasms / Q000032:analysis* / Q000276:immunology; D013967:Thyroiditis, Autoimmune / Q000276:immunology
D000951:Antigens, Neoplasm; D007106:Immune Sera; D013954:Thyroglobulin
Opredelenie soderzhaniia tireoglobulina v zlokachestvennykh i dobrokachestvennykh opukholiakh shchitovidnoĭ zhelezy, a takzhe v tireotoksicheskikh strumakh s pomoshch'iu immunologicheskogo metoda.