[DNA synthesis in connective tissue elements of regenerating skin under the influence of thyrocalcitonin and hypoxia].
The influence of TCT on the proliferation activity of the connective tissue elements of the regenerating skin in normal and lowered partial oxygen tension was studied by means of H3-thymidin autoradiography. Continuous saturation of the organism with exogenous TCT is characterized by an increase in the count of cells during the S-period of mitotic cycle, the DNA synthesis intensification, and a considerable decrease in the number of silver grains over the nuclei in the course of the 24-hour observation period; this can testify to the acceleration of the cell passage of mitotic cycle stages in normal and low partial oxygen tension in hypoxia.
D000818:Animals; D002116:Calcitonin / Q000494:pharmacology*; D002908:Chronic Disease; D003238:Connective Tissue / Q000378:metabolism; D004247:DNA / Q000096:biosynthesis*; D005347:Fibroblasts / Q000378:metabolism; D006097:Granulation Tissue / Q000378:metabolism; D000860:Hypoxia / Q000150:complications* / Q000378:metabolism; D008297:Male; D051381:Rats; D012867:Skin / Q000293:injuries*; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects
D002116:Calcitonin; D004247:DNA; D013936:Thymidine
Sintez DNK v soedinitel'notkannykh élementakh regeneriruiushcheĭ kozhi pod vliianiem tirokal'tsitonina i gipoksii.