A rapid gas-chromatographic method for the determination of drugs in clinical toxicology.
A rapid gas-chromatographic method for the qualitative and quantitative measurement of various drugs in human plasma and other body fluids has been developed. The extraction procedure is done within 5 min, and gas-chromatographic measurement carried out on 2 diverse columns with detection by flame ionisation detectors. The detection sensitivity of most drugs is high enough to determine their plasma levels in suicidally or accidentally poisoned patients. As shown for 6 different drugs, the limit of detection, the reproducibility and the accuracy are sufficient even for analysis of therapeutical plasma concentrations.
D002849:Chromatography, Gas / Q000379:methods; D006801:Humans; D004364:Pharmaceutical Preparations / Q000097:blood*; D014116:Toxicology / Q000379:methods
D004364:Pharmaceutical Preparations