Biliary excretion of some anionic derivatives of diethylstilboestrol and phenolphthalein in the guinea pig.
The metabolic fates and modes of excretion of diethylstilboestrol mono[35S]sulphate and diethylstilboestrol di[35S]sulphate were studied in the guinea pig. Comparative studies were also made with [G-3H]diethylstilboestrol and phenolphthalein di[35S]sulphate. Diethylstiboesterol di[35S]sulphate was extensively eliminated in the bile unchanged. After administration of diethylstilboestrol mono[35S]sulphate, extensive biliary elimination of radioactivity was also recorded. Radioactive components were identified as diethylstilboestrol disulphate, diethylstilboestrol monosulphate monoglucuronide and unchanged diethylstilboestrol monosulphate. When [G-3H]diethylstilboestrol was administered, 3H-labelled diethylstilboestrol monoglucuronide, diethylstilboestrol monosulphate monoglucuronide and diethylstilboestrol disulphate appeared in the bile. Phenolphthalein di[35S]sulphate was excreted unchanged in bile. These findings are discussed in relation to studies carried out in the rat [Barford, Olavesen, Curtis & Powell (1977) Biochem. J. 164, 423--430] and species differences are related to differences in enzyme activities in rat and guinea-pig liver.
D000818:Animals; D001646:Bile / Q000378:metabolism*; D004054:Diethylstilbestrol / Q000031:analogs & derivatives* / Q000378:metabolism; D006168:Guinea Pigs; D010635:Phenolphthaleins / Q000378:metabolism*; D013462:Sulfur Radioisotopes; D013463:Sulfuric Acid Esters / Q000378:metabolism; D014316:Tritium
D010635:Phenolphthaleins; D013462:Sulfur Radioisotopes; D013463:Sulfuric Acid Esters; D014316:Tritium; D004054:Diethylstilbestrol