Fluorescent analogue of ampicillin.
As the outcome of the reaction of ampicillin with 4-phenylspiro[furan-2(3H),1'-phthalane]-3,3'-dione (fluorescamine), the chemical analogue of ampicillin (F-AMPI) has been prepared. This preparation has manifested strong fluorescence in UV light. Some basic chemical and biological properties of this product such as chemical stability electrophoretic mobility, uniformity during thin-layer chromatography and ion-exchange chromatography, and antimicrobial activity were examined. The results were compared with values of the original antibiotic.
D000667:Ampicillin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002845:Chromatography; D004590:Electrophoresis, Paper; D005453:Fluorescence; D008826:Microbial Sensitivity Tests; D013050:Spectrometry, Fluorescence
D000667:Ampicillin