Mice protection with 2,4-monofurfurylidene-tetra-O-methyl-sorbitol (MSF) against acute toxicity due to Amanita phalloides.
2,4-Monofurfurylidene-tetra-O-methyl-sorbitol (MSF), which protects rats against a number of hepatotoxins, also reduces the death rate in mice receiving a crude Amanita phalloides powder (APP) by i.p. route, this protective effect being dose- and time-dependent. MSF-pretreatment greatly reduces APP-induced liver damage and blood serum GOT and GPT increase. MSF antagonizes APP more effectively than do mercaptopropionylglycine (MPG) and silymarin. The results are briefly discussed.
D000410:Alanine Transaminase / Q000097:blood; D000545:Amanita; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D004334:Drug Administration Schedule; D005260:Female; D005663:Furans / Q000008:administration & dosage / Q000627:therapeutic use; D007668:Kidney / Q000473:pathology; D008099:Liver / Q000473:pathology; D051379:Mice; D009145:Mushroom Poisoning / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control; D010936:Plant Extracts / Q000633:toxicity; D051381:Rats; D013012:Sorbitol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use
D005663:Furans; D010936:Plant Extracts; D013012:Sorbitol; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase