[Determination of antimicrobial activity of a combination of acidamfenicol, clotrimazole and dexamethasone in vitro (author's transl)].
The in vitro antimicrobial activity of the antieczematic Bay f 4797 was studied. This combination drug contains the three active components acidamfenicol, clotrimazole and dexamethasone (prospective trade name: Baycuten). Various bacterial and fungal species of importance in dermatology served as test organisms. All the bacterial strains examined were found to be moderately susceptible to acidamfenicol; clotrimazole showed good inhibitory values agaisnt all the fungal species and the gram-positive bacterial strains. Additionally it was checked whether a synergistic or antagonistic interaction occurs with respect to the antimicrobial activity. An interference which could lead to impairment of the therapeutic activity was not observed.
D001419:Bacteria / Q000187:drug effects*; D002701:Chloramphenicol / Q000031:analogs & derivatives* / Q000494:pharmacology; D003022:Clotrimazole / Q000494:pharmacology*; D003907:Dexamethasone / Q000494:pharmacology*; D004338:Drug Combinations; D004347:Drug Interactions; D005658:Fungi / Q000187:drug effects*; D007093:Imidazoles / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests
D004338:Drug Combinations; D007093:Imidazoles; D002701:Chloramphenicol; D003907:Dexamethasone; D003022:Clotrimazole
Bestimmung der antimikrobiellen Wirksamkeit einer Kombination aus Azidamfenicol, Clotrimazol und Dexamethason in vitro.