title: [Kinetic parameters of the rat liver monooxygenase system in the early stages of chemical carcinogenesis].
abstract: Functions of the liver monooxygenase system, participating in metabolism of 3,4-benzpyrene, were shown to vary significantly at different steps of carcinogenesis induced by 3,4-benzpyrene. These variations appear to be due to changes in the effect of monooxygenase-epoxide hydrase complex in rat liver microsomes.
mesh_terms: D000633:Aminopyrine N-Demethylase / Q000378:metabolism; D000818:Animals; D001579:Benzopyrene Hydroxylase / Q000378:metabolism; D001580:Benzopyrenes; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D003579:Cytochrome Reductases / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D009369:Neoplasms / Q000139:chemically induced* / Q000201:enzymology; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000201:enzymology; D010105:Oxygenases / Q000378:metabolism*; D051381:Rats; D013997:Time Factors
chemical_list: D001580:Benzopyrenes; D003577:Cytochrome P-450 Enzyme System; D010105:Oxygenases; D001579:Benzopyrene Hydroxylase; D000633:Aminopyrine N-Demethylase; D003579:Cytochrome Reductases
vernacular_title: Kineticheskie parametry monooksigenaznoĭ sistemy pecheni krys na rannikh étapakh khimicheskogo kantserogeneza.