Effect of histamine on respiratory movements and isolated ileum of pertussis-vaccinated mice. A negative study.
1. The sensitivity of mice, of the Swiss random bred strain, previously i.p. vaccinated with Bordetella pertussis Phase I cells, to histamine was investigated. 2. No response and no increase of the sensitivity of the respiratory system of the pertussis-vaccinated mice was observed during and after the inhaled histamine. 3. No contractions and no response of the isolated perfused ileum of the pertussis-vaccinated mice were observed after the addition of histamine. 4. No experimental or control mouse died during the whole experiment.
D000336:Aerosols; D000818:Animals; D005260:Female; D006632:Histamine / Q000008:administration & dosage / Q000494:pharmacology*; D007082:Ileum / Q000187:drug effects; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D010567:Pertussis Vaccine / Q000494:pharmacology*; D012119:Respiration / Q000187:drug effects*; D013997:Time Factors
D000336:Aerosols; D010567:Pertussis Vaccine; D006632:Histamine