Further researches on live influenza virus vaccines.
A/Port Chalmers 1/73 and A/Victoria 3/75 live vaccines were well tolerated after oral administration and showed good immunogenic properties in subjects devoid of immune-defence or having low antibody titer. A/Victoria 3/75 vaccine was prepared before the epidemiological appearance of the corresponding virus which demonstrates that the preparation of a vaccine with new strains can be made in a comparatively short time. Our experiments and controls allow us to establish that the oral administration of influenza virus, grown on chicken kidney embryo, elicits the appearance of HI antibodies in a high number of susceptible subjects. A 60% seroconversion rate obtained after administration of two doses represents a favourable result, the more so as the vaccine can be considered absolutely safe in very young subjects.
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000818:Animals; D000914:Antibodies, Viral; D000917:Antibody Formation; D002648:Child; D002675:Child, Preschool; D005289:Ferrets; D006389:Hemagglutinins, Viral; D006801:Humans; D007223:Infant; D009980:Influenza A virus / Q000276:immunology*; D007252:Influenza Vaccines / Q000008:administration & dosage* / Q000009:adverse effects; D008875:Middle Aged; D051381:Rats; D013997:Time Factors; D014613:Vaccines, Attenuated / Q000008:administration & dosage* / Q000009:adverse effects
D000914:Antibodies, Viral; D006389:Hemagglutinins, Viral; D007252:Influenza Vaccines; D014613:Vaccines, Attenuated