The oncogenic effect of immunosuppressive (cytotoxic) agents in (NZB x NZW) mice. II. Emergence of tumors in young animals treated with azathioprine and ifosfamide, including a histologic assessment of the neoplasms.
The age of (NZB x NZW) mice treated with immunosuppressive agents has been associated with an increased incidence of neoplastic disease in certain experimental situations. In this study, azathioprine administered daily over a period of 7 to 8 months significantly increased the occurrence of malignancies in animals aged 6 to 12 weeks at the start of treatment. No such increase was observed for ifosfamide. The resulting lesions observed in azathioprine and ifosfamide treated hybrids were predominantly lymphomas (60 to 80%) and could be classified according to two histologic types: Type I and II. The lymphomas in the ifosfamide groups could not be distinguished histologically from those in the azathioprine groups.
D000818:Animals; D001379:Azathioprine / Q000633:toxicity*; D002273:Carcinogens; D002277:Carcinoma / Q000139:chemically induced; D003520:Cyclophosphamide / Q000031:analogs & derivatives*; D005260:Female; D006965:Hyperplasia / Q000139:chemically induced; D007069:Ifosfamide / Q000633:toxicity*; D008208:Lymphatic System / Q000187:drug effects / Q000473:pathology; D008223:Lymphoma / Q000139:chemically induced / Q000473:pathology; D051379:Mice; D008814:Mice, Inbred NZB; D008815:Mice, Inbred Strains; D012509:Sarcoma / Q000139:chemically induced
D002273:Carcinogens; D003520:Cyclophosphamide; D001379:Azathioprine; D007069:Ifosfamide