The effect of apomorphine injection into caudate nucleus on electrical activity of some structures of the rabbit brain.
The studies were carried out on rabbits with chronically implanted electrodes and cannulas. Apomorphine, dopamine, or haloperidol were injected into the caudate nucleus of wakeful rabbits at a volume of 2 microliter. EEG was recorded from gyrus cinguli anterior, nucleus dorsalis raphe, and dorsal part of hippocampal formation. Apomorhine produced a dose-dependent desynchronization of EEG in the structure tested. This effect did not appear when dopaminergic receptors were blocked by previous systemic (1.2 mg/kg) or intracaudal (10microgram) injection of heloperidol.
D000818:Animals; D001058:Apomorphine / Q000008:administration & dosage / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects*; D002421:Caudate Nucleus; D003344:Cortical Synchronization; D004298:Dopamine / Q000494:pharmacology; D004569:Electroencephalography; D006220:Haloperidol / Q000494:pharmacology; D007267:Injections; D008032:Limbic System; D011817:Rabbits; D011903:Raphe Nuclei
D006220:Haloperidol; D001058:Apomorphine; D004298:Dopamine