Oestrogen induction of riboflavin-binding protein in immature chicks.
In hyperthyroid chicks, oestrogen-induced plasma accumulation of riboflavin-binding protein was diminished, whereas the reverse situation prevailed in hypothyroid birds. Under hyperthyroid conditions, higher concentrations of oestrogen were required to elicit a response comparable with that obtained in normal birds treated with lower concentrations of the hormone. Elevated hepatic cytochrome P-450 concentrations and decreased half-life of the induced protein in hyperthyroid animals suggest that higher catabolic rates of the inducer and induced protein are contributory factors to the diminished response.
D000818:Animals; D002352:Carrier Proteins / Q000097:blood*; D002645:Chickens; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004958:Estradiol / Q000494:pharmacology*; D004967:Estrogens / Q000494:pharmacology; D006980:Hyperthyroidism / Q000097:blood; D007037:Hypothyroidism / Q000097:blood; D008099:Liver / Q000378:metabolism; D008297:Male; D012256:Riboflavin / Q000378:metabolism*; D013974:Thyroxine / Q000494:pharmacology
D002352:Carrier Proteins; D004967:Estrogens; D004958:Estradiol; D003577:Cytochrome P-450 Enzyme System; D013974:Thyroxine; D012256:Riboflavin