title: Regional blood flow redistribution during early burn shock in the guinea pig.
abstract: The distribution of blood flow was determined with radioactive microspheres following scald injury in guinea pigs. Burn was induced in halothane-anesthetized guinea pigs by a 3-sec immersion to the xiphoid process in 100 degree C water. Cardiac output and fractional blood flow measurements were made at preburn, 15-min postburn, and 75-min post-burn. In the scalded animals cardiac output decreased 58% by 75 min postburn. Three different blood flow responses to burn were noted: a) Brain, heart, hepatic artery, and adrenals received an increased fraction of the cardiac output; b) the fractional distribution of the diaphragm, liver (portal), spleen, gastrointestinal tract, muscle (from burned portion of the body), and bone remained constant; while c) the pancreas, burned skin, nonburned skin, and adipose tissue received a reduced fraction of the cardiac output. Although some regions of the body (i.e., brain and heart) received a greater percentage of the total cardiac output after burn injury, the cardiac output decrease was sufficient to cause a depression in absolute blood flow to all but two sites (adrenals and hepatic artery).
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity; D002056:Burns / Q000503:physiopathology*; D002302:Cardiac Output; D005260:Female; D006168:Guinea Pigs; D006339:Heart Rate; D006439:Hemodynamics; D008297:Male; D012039:Regional Blood Flow; D012774:Shock, Traumatic / Q000503:physiopathology*