Effect of histidine on morphine-induced changes in brain histamine.
Chronic morphine administration to rats resulted in a significant decrease in the hypothalamic and cerebro-cortical histamine concentrations. These low histamine values were restored to control levels when L-histidine was administered daily along with morphine treatment. Chronic treatment with L-histidine prevented the midbrain and cerebro-cortical histamine depletion in morphine-withdrawn rats, whereas in the hypothalamus the histamine level remained significantly decreased. The present data suggests that histamine may play a role in morphine dependence and withdrawal.
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D002540:Cerebral Cortex / Q000032:analysis; D006632:Histamine / Q000032:analysis*; D006639:Histidine / Q000494:pharmacology*; D007031:Hypothalamus / Q000032:analysis; D008297:Male; D008636:Mesencephalon / Q000032:analysis; D009020:Morphine / Q000037:antagonists & inhibitors*; D051381:Rats; D013997:Time Factors
D006639:Histidine; D009020:Morphine; D006632:Histamine