[Dopamin-beta-hydroxylaseaktivität im Plasma von Dialysepatienten (author's transl)].
Plasma dopamin-b-hydroxylase (DBH) was studied in 70 healthy control persons and in 37 hemodialysed patients. Basal DBH in controls corresponded to 50.0 +/- 29.3 IU. There was was no significant difference between males (53.9 +/1 33.8 IU) and females (47.4 +/- 25 IU); no correlation could be found between age and plasma DBH. In hemodialysed patients basal DBH levels were significantly (p less than 0.01) decreased (32.5 %/- 17.6 IU), suggesting lowered sympathetic activity and/or abnormalities in release, distribution space, or metabolism of DBH. During hemodialysis plasma DBH activity rose during ultrafiltration. This finding indicates a directionally appropriate sympathetic reflex response to volume depletion in dialysed patients.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001835:Body Weight; D004299:Dopamine beta-Hydroxylase / Q000097:blood*; D005260:Female; D006339:Heart Rate; D006400:Hematocrit; D006801:Humans; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D012737:Sex Factors; D013564:Sympathetic Nervous System / Q000503:physiopathology; D014462:Ultrafiltration; D014511:Uremia / Q000097:blood* / Q000503:physiopathology
D004299:Dopamine beta-Hydroxylase
Plasma Dopamin-beta-Hydroxylase-Activity in Dialysed Patients.