Vinblastine inhibition of microtubule assembly in vitro.
The effect of vinblastine on the in vitro polymerization of tubulin was investigated. It has been shown that the presence of VLB prevents the assembly of tubulin in rat brain extracts, and the addition of VLB to assembled microtubules results in their rapid depolymerization. The polymerization was monitored by viscometry and electron microscopy.
D003078:Colchicine / Q000494:pharmacology; D006023:Glycoproteins / Q000378:metabolism*; D007700:Kinetics; D008870:Microtubules / Q000187:drug effects* / Q000378:metabolism; D014404:Tubulin / Q000378:metabolism*; D014747:Vinblastine / Q000494:pharmacology*; D014783:Viscosity
D006023:Glycoproteins; D014404:Tubulin; D014747:Vinblastine; D003078:Colchicine