title: [Isolation and identification of some metabolites of clofedanol from human urine (author's transl].
abstract: 10 excretory products of Clofedanol (1-(o-chlorphenyl)-1-phenyl-3-dimethylaminopropanol) were identified in human urine. The following five products were extracted with chloroform at pH 1--2: o-(chlorphenyl)-phenylmethane (I), benzophenone (II), o-chlorbenzophenone (III), benzhydrol (IV), and o-(chlorphenyl)-beta-phenylacrolein (V). Two compounds were extracted with chloroform at pH 13--14: unchanged Clofedanol and 1-(o-chlorphenyl)-1-phenyl-3-dimethylaminopropene-1 (VI). N,N-dimethylamino-acetic acid (VII) was also identified in urine. Clofedanol and metabolite IV were present as free compounds, and they were also found after hydrolysis of metabolites VIII and IX with beta-glucuronidase.
mesh_terms: D000996:Antitussive Agents / Q000652:urine*; D001559:Benzhydryl Compounds / Q000652:urine; D001711:Biotransformation; D002845:Chromatography; D006801:Humans; D013058:Mass Spectrometry; D011412:Propanolamines / Q000652:urine*
chemical_list: D000996:Antitussive Agents; D001559:Benzhydryl Compounds; D011412:Propanolamines; C010432:clofedanol
vernacular_title: Isolierung einiger Metaboliten des Clofedanol aus menschlichem Harn und ihre Identifizierung.