Assignment of the gene for glyoxalase I to region p21 leads to pter of human chromosome 6.
Using somatic cell hybrids between TK-deficient mouse cells and white blood cells derived from a patient with a translocation of the region p21 leads to pter of chromosome 17, we have assigned the gene for human GLO, to region p21 leads to pter of chromosome 6. Since the HLA region is only 10 cM distant from GLO, these results also confirm that the HLA region is located on the short arm of human chromosome 6.
D000818:Animals; D002902:Chromosomes, Human, 16-18; D002906:Chromosomes, Human, 6-12 and X; D005796:Genes; D006680:HLA Antigens / Q000302:isolation & purification; D006801:Humans; D006822:Hybrid Cells / Q000201:enzymology; D007791:Lactoylglutathione Lyase / Q000235:genetics*; D008190:Lyases / Q000235:genetics*; D051379:Mice; D014178:Translocation, Genetic
D006680:HLA Antigens; D008190:Lyases; D007791:Lactoylglutathione Lyase