Dominant-lethal assay of selected cytostatics.
Dominant-lethal assays in male mice were made with the following cytostatics: Cyclophosphamide, TS-160, Edikron, Penberol, Cytembena, Mercaptopurine, Butocin, and Damvar. The cytostatics were administered mostly for 14-day periods, with the exception of Butocin (7 days) and high doses of Cyclophosphamide and TS-160 (single administrations). From the first day of administration on, the males were mated with intact females mostly at eight one-week intervals, and the quality of pregnancy was checked. Antifertility effects were found with TS 160, Penberol (at high dosage), and Mercaptopurine. Effects on permiogenesis with genetic risk were found with Cyclophosphamide, TS-160, Mercaptopurine, and less marked ones also with Cytembena. The effects were mostly manifested by increases in the numbers of early fetal resorptions, and less frequently by preimplantation loss of ova. No genetic risk was revealed by the assay in the cytostatics Edikron, Penberol, Butocin, and Damvar.
D000179:Acrylates / Q000009:adverse effects; D000477:Alkylating Agents / Q000009:adverse effects*; D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D003520:Cyclophosphamide / Q000009:adverse effects; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005260:Female; D005327:Fetal Resorption / Q000139:chemically induced; D007248:Infertility, Male / Q000139:chemically induced; D008297:Male; D015122:Mercaptopurine / Q000009:adverse effects; D051379:Mice; D009153:Mutagens; D009588:Nitrogen Mustard Compounds / Q000009:adverse effects; D011247:Pregnancy; D013091:Spermatogenesis / Q000187:drug effects
D000179:Acrylates; D000477:Alkylating Agents; D000964:Antimetabolites, Antineoplastic; D009153:Mutagens; D009588:Nitrogen Mustard Compounds; C009802:2,2',2''-trichlorotriethylamine; D003520:Cyclophosphamide; D015122:Mercaptopurine