Candida meningitis in the newborn.
The incidence of Candida meningitis in the neonatal period is increasing, and 63% of reported patients have either died or are mentally retarded. We report a newborn with Candida meningitis and arthritis who did well after treatment with intravenous and intrathecal amphotericin B, along with oral flucytosine.
D000284:Administration, Oral; D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use*; D001170:Arthritis, Infectious / Q000150:complications / Q000188:drug therapy; D002177:Candidiasis / Q000150:complications / Q000188:drug therapy*; D003596:Cytosine / Q000031:analogs & derivatives*; D004359:Drug Therapy, Combination; D005437:Flucytosine / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000150:complications / Q000188:drug therapy*; D007263:Infusions, Parenteral; D007278:Injections, Spinal; D008297:Male; D008581:Meningitis / Q000150:complications / Q000188:drug therapy*
D000666:Amphotericin B; D003596:Cytosine; D005437:Flucytosine