Renal and testicular damage following dermal application of the flame retardant tris (2,3-dibromopropyl) phosphate.
Tris(2,3-dibromopropyl) phosphate (TRIS) was the most popular flame retardant chemical used in children's sleepwear. Acute toxicological data indicated that TRIS was low in toxicity. Since human exposure to TRIS-treated fabrics could occur for long periods of time, a subchronic study was undertaken to obtain additional information. The dermal application of TRIS (neat) at a dose of 1 ml/kg (2.27 g/kg) to the clipped backs of albino rabbits, once each week for 3 months, resulted in testicular atrophy and chronic interstitial nephritis in males. Females did not show any adverse effects.
D000287:Administration, Topical; D000818:Animals; D001284:Atrophy; D001835:Body Weight / Q000187:drug effects; D005260:Female; D005411:Flame Retardants / Q000008:administration & dosage / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D008099:Liver / Q000187:drug effects*; D008297:Male; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000473:pathology; D009929:Organ Size / Q000187:drug effects; D011817:Rabbits; D012737:Sex Factors; D012869:Skin Absorption; D013733:Testicular Diseases / Q000139:chemically induced* / Q000473:pathology; D013737:Testis / Q000187:drug effects* / Q000473:pathology; D013997:Time Factors
D005411:Flame Retardants