title: Alphaxalone distribution in rat tissues.
abstract: A method for the extraction and gaschromatographic determination of 3alpha-hydroxy-5alpha-pregnane-11,20-dione (alphaxalone, main active component of Althesin) in microgram amount in plasma and tissues is described. The slow i.v. infusion of Althesin in the rat gives uniform alphaxalone distribution in tissues, slight localization in the fat and brain levels comparable to plasma concentration.
mesh_terms: D000530:Alfaxalone Alfadolone Mixture / Q000008:administration & dosage; D000818:Animals; D002849:Chromatography, Gas; D005260:Female; D008297:Male; D011277:Pregnanediones / Q000378:metabolism*; D051381:Rats; D012737:Sex Factors; D014018:Tissue Distribution
chemical_list: D011277:Pregnanediones; D000530:Alfaxalone Alfadolone Mixture