Experimental arthrosis from intra-articular vitamin A injection in the rabbit. Morphological and biochemical study: considerations on the pathogenesis of human arthrosis in relation to the experimental model.
The key to the pathogenesis of arthrosis lies in the mechanism responsible for the initial lesions. In this experimental work the possibility of producing arthrosic changes is demonstrated by activating lysosomal chondrocytic enzymes by the intra-articular injection of Vitamin A in rabbits. On the basis of the experimental results the authors discuss the possible role that activation of the lysosomal hydrolytic enzymes might play in producing primary and secondary arthrosis in humans. They advance the hypothesis that this mechanism may be the common final step in the degradation of the articular cartilage, whatever the aetiological factor.
D000135:Acid Phosphatase / Q000378:metabolism*; D000818:Animals; D001168:Arthritis / Q000139:chemically induced* / Q000209:etiology; D002237:Carbohydrate Dehydrogenases / Q000378:metabolism*; D002358:Cartilage, Articular / Q000201:enzymology*; D004789:Enzyme Activation; D005966:Glucuronidase / Q000378:metabolism*; D007270:Injections, Intra-Articular; D007719:Knee Joint; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D008247:Lysosomes / Q000201:enzymology; D011817:Rabbits; D014533:Uridine Diphosphate Glucose Dehydrogenase / Q000378:metabolism*; D014801:Vitamin A / Q000008:administration & dosage
D014801:Vitamin A; D002237:Carbohydrate Dehydrogenases; D014533:Uridine Diphosphate Glucose Dehydrogenase; D007770:L-Lactate Dehydrogenase; D000135:Acid Phosphatase; D005966:Glucuronidase