title: [Increased regional hepatic blood circulation and bile flow following application of peloid paraffin packs on rat abdominal wall].
abstract: In Sprague-Dawley rats anaesthetized with pentobarbital-Na and breathing spontaneously, regional hepatic blood flow (rHBF) is measured in the liver in situ and during application of peloid paraffin packs on the abdominal wall. Blood flow measurements are performed by means of the 85Kr(beta)-clearance technique after slug injection of the dissolved indicator into the thoracic aorta. Mean arterial blood pressure is monitored continuously. After exposing the liver surface by an incision at the right costal margin, rHBF is measured, 5, 15, 35 and 45 min later. The results of a control series clearly show that there exists a time-dependent decrease of rHBF at comparable M ABP values and normal respiratory gas parameters. If peloid paraffin packs are applied on the abdominal wall 25 min after the surgery, this time-dependent decrease of rHBF ceases and rHBF then increases to initial values. In comparison to the control series the application of peloid paraffin packs on the abdominal wall causes a significant increase in rHBF of about 20--39%. Experiments on bile flow of rats show that under normal conditions and after insertion of a cannula into the common hepatic duct, a time-independent mean flow of 0.053 ml bile/kg body weight/min occurs. The application of peloid paraffin packs 45 min after the suture of the abdominal wall yields a significant increase in bile flow of 18% within 15 min.
mesh_terms: D000818:Animals; D001646:Bile / Q000378:metabolism*; D001794:Blood Pressure; D001835:Body Weight; D006339:Heart Rate; D066298:In Vitro Techniques; D008102:Liver Circulation; D008297:Male; D010232:Paraffin; D051381:Rats; D012119:Respiration; D013997:Time Factors
chemical_list: D010232:Paraffin
vernacular_title: Steigerung der regionalen Leberdurchblutung und des Galleflusses nach Applikation von Peloid-Paraffin-Packungen auf die Bauchhaut von Ratten.