[Development of new antiepileptics. II. Anticonvulsant effect of hydantoin derivatives].
From a series of N-substituted hydantoin derivatives, 1-phenyl-3-(o-chloro-p-sulfonamide-phenyl)-hydantoin was found to exhibit the best anticonvulsant activity against electroshock seizures. This substance showed also a weak activity against pentylenetetrazole seizures, as well as minor analgesic and sedative effects. The toxic effects are negligible; the lethal dose in mice was higher than 5000 mg/kg p.o. The other tested hydantoin derivatives showed much weaker anticonvulsant activities.
D000700:Analgesics; D000818:Animals; D000927:Anticonvulsants; D004597:Electroshock; D006827:Hydantoins / Q000494:pharmacology* / Q000633:toxicity; D006993:Hypnotics and Sedatives; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors
D000700:Analgesics; D000927:Anticonvulsants; D006827:Hydantoins; D006993:Hypnotics and Sedatives; D010433:Pentylenetetrazole
Die Entwicklungen neuer Antiepileptika. Teil II: Antikonvulsive Wirkung einiger Hydantoin-Derivate.