Evaluation of drug-induced reno-renal vasomotor reflex in the dog.
1. Renal arterial infusions of endogenous vasoactive compounds were administered, and elctromagnetic flow probes were used to measure simultaneous ipsilateral and contralateral renal blood flow. 2. The expected ipsilateral renal blood flow changes resulting from infusions of acetylcholine, noradrenaline, angiotension II, bradykinin and PGE2 were observed. There were no transient, phasic or sustained contralateral renal blood flow changes. 3. These results suggest that a previously hypothesized reno-renal vasomotor reflex communication does not exist. The discrepancies between these present studies and previous ones proposing such a reflex may be due to the methods chosen for measurement of renal blood flow.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D055590:Electromagnetic Phenomena; D005260:Female; D007668:Kidney / Q000098:blood supply / Q000187:drug effects*; D008297:Male; D012018:Reflex / Q000187:drug effects*; D012039:Regional Blood Flow / Q000187:drug effects