[Action of aminazine and tisercin in a changed functional state of the body].
Experiments with rats evidenced that the pain-allaying and hypothermal action of chlorpromazine and tisercin (5 and 1 mg/kg) remains intact with an upset homeostasis against the background of a phlogogenic mixture and inflammation effect, though it becomes less potent. These drugs increase the higher permeability of the blood-histological barrier of the suprarenals caused by the stress (introduction of an irritating mixture) and inflammation.
D000311:Adrenal Glands / Q000187:drug effects; D000698:Analgesia; D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D002463:Cell Membrane Permeability / Q000187:drug effects; D002746:Chlorpromazine / Q000494:pharmacology*; D006706:Homeostasis / Q000187:drug effects; D007036:Hypothermia, Induced; D008728:Methotrimeprazine / Q000494:pharmacology*; D051381:Rats; D013312:Stress, Physiological / Q000139:chemically induced*; D013950:Thymus Gland / Q000187:drug effects; D013997:Time Factors
D008728:Methotrimeprazine; D002746:Chlorpromazine
Deĭstvie aminazina i tizertsina v usloviiakh izmenennogo funkstional'nogo sostoianiia organizma.