The effect of essential fatty acid deprivation on the metabolic transformations of [1(-14)C]linolenate in developing rat brain.
Linolenic acid undergoes rapid metabolism in the brain of 21-day-old rats. Radioactivity is rapidly transferred from linolenic acid to the C20 (n--3) fatty acids while that in docosapentaenoic acid (22 : 5 n--3) and docosahexaenoic acid (22 : 6 n--3) gradually increases. A greater proportion of the radioactivity is associated with the polyunsaturated and less with saturated and monounsaturated fatty acids in essential fatty acid-deprived rats relative to controls.
D000818:Animals; D001921:Brain / Q000254:growth & development / Q000378:metabolism*; D005228:Fatty Acids, Essential / Q000172:deficiency*; D005260:Female; D007278:Injections, Spinal; D008042:Linolenic Acids / Q000008:administration & dosage / Q000378:metabolism*; D008297:Male; D010743:Phospholipids / Q000378:metabolism; D051381:Rats
D005228:Fatty Acids, Essential; D008042:Linolenic Acids; D010743:Phospholipids