title: Evolutionary changes of alpha-crystallin and the phylogeny of mammalian orders.
abstract: The sequences of the A chains of the eye lens protein alpha-crystallin from seventeen mammalian species were compared. They showed a generally slow rate of evolution, but with marked variations in different lineages. Most substitutions have occurred in the C-terminal part of the chain, which probably forms part of the surface of the alpha-crystallin aggregate. The ancestral sequence method of Dayhoff revealed interesting indications about the phylogenetic relationships between the eleven mammalian orders that were represented by the investigated species. Most evident was the divergence of marsupial and placental orders. A notable resemblance between the hyrax and elephant sequences was observed, setting them apart from the ungulates, including whale. Primates, rodents, lagomorphs, insectivores and tupaiids seem to derive from a common stem group. These phylogenetic inferences are discussed in relation to current palaeontological and taxonomical opinions, and compared to evidence from other protein sequence data.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D005075:Biological Evolution; D003459:Crystallins / Q000235:genetics; D003580:Cytochromes; D005340:Fibrinogen; D006454:Hemoglobins; D008322:Mammals / Q000235:genetics*; D009211:Myoglobin; D010802:Phylogeny
chemical_list: D003459:Crystallins; D003580:Cytochromes; D006454:Hemoglobins; D009211:Myoglobin; D005340:Fibrinogen