A new approach to the problem of retinal neovascularization.
Tumor cells introduced into the rabbit vitreous produced a form of retinal neovascularization, but only when the tumor cells were in direct contact with the vascularized retina. This contrasted with the production of neovascularization at a distance of several millimeters in other angiogenesis models. An extract of adult rabbit vitreous was found to inhibit the growth of limbal neovascularization induced by tumors implanted in the rabbit corneal stroma. The experimental model of retrolental fibroplasia provides a bioassay to investigate further the apparent inhibitory substances in the vitreous.
D043925:Angiogenesis Inducing Agents / Q000096:biosynthesis / Q000502:physiology; D000818:Animals; D002415:Cats; D004285:Dogs; D008954:Models, Biological; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental; D010100:Oxygen; D011817:Rabbits; D012171:Retinal Vessels / Q000503:physiopathology*; D012178:Retinopathy of Prematurity / Q000378:metabolism / Q000503:physiopathology; D014020:Tissue Extracts / Q000494:pharmacology; D014184:Transplantation, Homologous; D014822:Vitreous Body / Q000601:surgery
D043925:Angiogenesis Inducing Agents; D014020:Tissue Extracts; D010100:Oxygen