Action of some non-steroid anti-inflammatory drugs on skin anaphylaxis due to ovalbumin in the rat and the guinea pig.
Six non-steroidal anti-inflammatory drugs, metiazinic and niflumic acids, iburofen, indometacin, ketoprofen and phenylbutazone, were tested on two anaphylactic skin reactions to ovalbumin: the passive reaction in the rat and active anaphylaxis in the guinea pig. In the rat, only niflumic and metiazinic acids reduced very slightly the reaction. In the guinea pig, ibuprofen, phenylbutazone, metiazinic acid and ketoprofen had good activity. The results are discussed.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D006168:Guinea Pigs; D006967:Hypersensitivity / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D010047:Ovalbumin / Q000276:immunology; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects*; D051381:Rats; D012871:Skin Diseases / Q000188:drug therapy / Q000276:immunology
D000893:Anti-Inflammatory Agents; D010047:Ovalbumin