Synthesis of thromboxane B2 and prostaglandins by bovine gastric mucosal microsomes.
Bovine gastric mucosal microsomes synthesize prostaglandins from arachidonic acid but thromboxane B2 is the principal product. Thromboxane B2 synthesis occurs at an appreciable rate from endogenous precursor but more rapidly with added arachidonate. Nonsteroidal antiinflammatory drugs inhibited synthesis of prostaglandins and thromboxanes with the following decreasing order of potency: indomethacin, fenoprofen, acetylsalicylic acid, phenylbutazone, sulfinpyrazone, and acetaminophen.
D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism; D002417:Cattle; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D005753:Gastric Mucosa / Q000378:metabolism*; D013058:Mass Spectrometry; D008861:Microsomes / Q000378:metabolism*; D011448:Prostaglandin Antagonists / Q000494:pharmacology; D011453:Prostaglandins / Q000096:biosynthesis*; D013929:Thromboxane B2 / Q000096:biosynthesis*; D013931:Thromboxanes / Q000096:biosynthesis*
D001095:Arachidonic Acids; D011448:Prostaglandin Antagonists; D011453:Prostaglandins; D013931:Thromboxanes; D013929:Thromboxane B2