[Antimycotic drugs. 5th Communication: carbocyclically and heterocyclically substituted trifluoromethylpyrimidines (author's transl)].
In view of the role that methoxy and methylthio groups play in antimycotic drugs, 2-methoxy- and 2-methylthio-trifluoromethylpyrimidines (3a-h) have been developed by condensation of O-methylisourea (1a) or S-methylisothiourea (1b), respectively, with beta-diketones (2a-d). Opposed to this course, the reaction of 1b with 1,1,1,2,2,3,3-heptafluoro-6-(2-thienyl)-4,6-hexanedione (4) fails to lead to ring closure but rather yields 4,4,5,5,6,6,6-heptafluoro-3-(2-methyl-1-thioureido)-1-(2-thienyl)-1-hexen-1,3-diol (5).
D000935:Antifungal Agents / Q000138:chemical synthesis; D055598:Chemical Phenomena; D002621:Chemistry; D011743:Pyrimidines / Q000138:chemical synthesis / Q000494:pharmacology*
D000935:Antifungal Agents; D011743:Pyrimidines
Antimykotische Wirkstoffe 5. Mitteilung: Carbocyclisch und heterocyclisch substituierte Trifluormethylpyrimidine.