Hemoglobin Gavello - alpha 2 beta 2 47 (CD6) Asp replaced by Gly. A new hemoglobin variant from Polesine (Italy).
During a survey for abnormal hemoglobins in Polesine (a region north of the Po river, where beta-thalassemia is very frequent) a slow moving variant was noted in a 79-yr-old woman living in Gavello, a small town in the province of Rovigo. Structural studies demonstrated a previously undescribed amino acid substitution, beta47 Asp replaced by Gly. This new variant has been named Hb Gavello.
D000368:Aged; D001224:Aspartic Acid / Q000378:metabolism*; D004588:Electrophoresis, Cellulose Acetate; D005260:Female; D005998:Glycine / Q000378:metabolism*; D006455:Hemoglobins, Abnormal; D006801:Humans; D007558:Italy
D006455:Hemoglobins, Abnormal; D001224:Aspartic Acid; D005998:Glycine