The effect of the bis-(2-pyridil-1-oxide)-disulfide adduct with Mg SO4 on the scalp and hair lipids.
Animal experiments demonstrate that the topical application of the bis-(2-pyridyl-l-oxide)- disulfide adduct with MgSO4(Omadine MDS) increases the mitosis rate and also the size of the sebaceous glands in the Syrian hamster ear. Corresponding results have been obtained in human subjects in whom the secretion of the sebaceous glands was shown to increase after application of the compound. The studies also demonstrate that it decreases the fatty acid content of the scalp lipids. In this way a seborrhoea oleosa is transformed into a seborrhoea sicca. The undesired side effect of a stimulation of the sebaceous gland secretion is thus in part compensated for the patient's subjective feeling.
D000293:Adolescent; D000818:Animals; D006224:Cricetinae; D003497:Cyclic N-Oxides / Q000494:pharmacology; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D006197:Hair / Q000187:drug effects* / Q000378:metabolism; D006203:Hair Preparations / Q000494:pharmacology*; D006801:Humans; D050356:Lipid Metabolism; D008297:Male; D008647:Mesocricetus; D011725:Pyridines / Q000494:pharmacology*; D012535:Scalp / Q000187:drug effects* / Q000378:metabolism; D013997:Time Factors; D014280:Triglycerides / Q000378:metabolism
D003497:Cyclic N-Oxides; D005230:Fatty Acids, Nonesterified; D006203:Hair Preparations; D011725:Pyridines; D014280:Triglycerides