Pathological study on amyloidosis--scanning electron microscopic observation of amyloid-laden mouse liver.
Amyloidosis of liver in mice induced by casein injection was studied by scanning electron microscopy (SEM). In the fractured-surfaces of the central portion of amyloid nodules, they appeared as chestnut-bur-like structures and were composed of numerous thread-like structures of fasciculated amyloid fibrils and of stick-like structures of amyloid bundles in three dimensional figure. In the cytoplasm of the Kupffer cell, amyloid bundles were revealed as band-like bulges. These bulges were projected from the Kupffer cell into the Disse's space and continued with thread-like structures outside the cytoplasm of Kupffer cells.
D000686:Amyloidosis / Q000473:pathology*; D000818:Animals; D007728:Kupffer Cells / Q000648:ultrastructure; D008099:Liver / Q000648:ultrastructure*; D051379:Mice; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning