The effects of silybin on experimental phalloidine poisoning.
Histochemical and histoenzymological studies carried out on liver slices of the mouse show that silybin both as prophylactic and curative treatment, inhibits the disorders of metabolic activity brought about by phallodine and maintains enzymatic activities at levels comparable with those of the control animals. Silybin, when administered alone, produces only minor changes in activities. As with silymarin, the only notable effect is an increased activity of alkaline phosphatase. The mode of action of these two substances appears to be the same.
D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control; D005419:Flavonoids / Q000627:therapeutic use*; D006651:Histocytochemistry; D008297:Male; D051379:Mice; D009842:Oligopeptides / Q000506:poisoning*; D010590:Phalloidine / Q000506:poisoning*; D012838:Silymarin / Q000627:therapeutic use*
D005419:Flavonoids; D009842:Oligopeptides; D012838:Silymarin; D010590:Phalloidine