title: [Vaginal absorption of econazole].
abstract: After vaginal application econazol is absorbed to a high degree. Plasma levels are maintained for a relatively long period. Metabolism occurs in the vagina already. As there are no objections concerning toxicology the fact of absorption is considered positive from the therapeutical view-point because this drug does exert its effect not only in the vaginal cavity but also in the epithelium. It is suggested that vaginal absorption is influenced by cervical mucus.
mesh_terms: D000042:Absorption; D000287:Administration, Topical; D000368:Aged; D004464:Econazole / Q000008:administration & dosage / Q000378:metabolism*; D004848:Epithelium / Q000378:metabolism; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000378:metabolism*; D008875:Middle Aged; D009824:Ointments; D014621:Vagina / Q000378:metabolism*
chemical_list: D007093:Imidazoles; D009824:Ointments; D004464:Econazole
vernacular_title: Untersuchungen zur vaginalen Resorption von Econazol.