Mammary gland differentiation in adult male rat--effect of prenatal exposure to cyproterone acetate.
Breast tissue of adult male Holtzman rats exposed to cyproterone acetate during embryonic differentiation showed presence of specific estradiol receptor proteins and C-19 steroid aromatase. We reported similar findings in gynecomastia in man. It is therefore proposed that gynecomastia probably results from failure of adequate testosterone action on the breast primordia during embryonic differentiation.
D000735:Androstenedione / Q000378:metabolism; D000818:Animals; D001141:Aromatase / Q000378:metabolism; D002454:Cell Differentiation; D003534:Cyproterone / Q000494:pharmacology*; D004958:Estradiol / Q000378:metabolism; D004967:Estrogens / Q000378:metabolism; D005260:Female; D008297:Male; D008321:Mammary Glands, Animal / Q000196:embryology / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D011960:Receptors, Estrogen / Q000378:metabolism
D004967:Estrogens; D011960:Receptors, Estrogen; D000735:Androstenedione; D004958:Estradiol; D003534:Cyproterone; D001141:Aromatase