Derivatives of methyl vinyl sulfone. Distribution and elimination of methyl (2,2-diphenyl)-vinyl sulfone labelled with 14carbon in mice.
The investigation of methyl (2,2-diphenyl)-vinyl sulfone (14C-MDVS) administered i.p. in mice shows that this product appears rapidly in the general circularoty system. The blood concentration of MDVS reaches a maximum 1 h after injection. Part of the MDVS is bound to the plasma proteins. Infrared spectrometry analysis of radioactive products eliminated by the urine confirms that the product is not split, but also reveals the presence of hydroxyl and carbonyl groups in the metabolic conversion products.
D000818:Animals; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D051379:Mice; D011485:Protein Binding; D013450:Sulfones / Q000378:metabolism*; D013997:Time Factors; D014018:Tissue Distribution; D014753:Vinyl Compounds / Q000378:metabolism
D013450:Sulfones; D014753:Vinyl Compounds