[Pharmacological effect of tinofedrine on cerebral and peripheral hemodynamics in the dog (author's transl)].
l-(+)-alpha-(1-[(3,3-Di-3-thienylallyl)amino]-ethyl)-benzyl alcohol hydrochloride (Tinofedrine, D 8955, Novocebrin), a new drug, synthetized in our research laboratories, has been tested in dogs with regard to the improvement of cerebral and peripheral blood flow. Direct electromagnetic flow measurement at the vertebral artery as well as 133xenon wash-out method showed a strong and long-lasting increase of cerebral and femoral blood flow following intravenous as well as oral administration. No decrease of activity was observed after repeated intravenous application. Comparative studies with several standard drugs of the same field of indication proved a remarkable superiority of tinofedrine in our experimental conditions.
D000818:Animals; D001537:Bencyclane / Q000494:pharmacology; D001592:Benzyl Alcohols / Q000008:administration & dosage / Q000494:pharmacology*; D001593:Benzyl Compounds / Q000494:pharmacology*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D002928:Cinanserin / Q000494:pharmacology; D004285:Dogs; D006439:Hemodynamics / Q000187:drug effects*; D009540:Nicotinyl Alcohol / Q000494:pharmacology; D012039:Regional Blood Flow / Q000187:drug effects; D013876:Thiophenes / Q000494:pharmacology*; D013997:Time Factors; D014971:Xanthinol Niacinate / Q000494:pharmacology
D001592:Benzyl Alcohols; D001593:Benzyl Compounds; D013876:Thiophenes; D001537:Bencyclane; D014971:Xanthinol Niacinate; D009540:Nicotinyl Alcohol; D002928:Cinanserin
Pharmakologische Wirkung von Tinofedrin auf die zerebrale und periphere Hämodynamik des Hundes.