title: Exceptionally high serum erythropoietin activity in an anephric patient with severe anemia.
abstract: An exceptionally high serum erythropoietin (EPO) activity was documented in an anephric patient with severe anemia who required transfusions every 4 weeks. The patient's serum EPO was comparable to normal human urinary EPO in the polycythemic mouse assay and was neutralized by an antiserum against EPO. The patient's serum inhibited EPO stimulated-heme synthesis by normal human marrow cells in vitro. This finding suggests that an inhibitor played an important role in causing the anemia of this uremic patient.
mesh_terms: D000293:Adolescent; D000740:Anemia / Q000097:blood* / Q000150:complications / Q000378:metabolism; D001853:Bone Marrow / Q000378:metabolism; D002478:Cells, Cultured; D004921:Erythropoietin / Q000378:metabolism*; D005260:Female; D005921:Glomerulonephritis / Q000601:surgery; D006801:Humans; D009392:Nephrectomy; D006435:Renal Dialysis
chemical_list: D004921:Erythropoietin