title: Study of the repercussions on blood of acute experimental inflammation in rats. II. Blood changes in the course of carrageenin induced inflammation.
abstract: Repercussions on blood of inflammation induced by carrageenin injection in the four paws of rats were studied. Two stages were observed. 4 h after carrageenin injection, a high fall in leucocyte count and a small decrease in blood total proteins and blood fibrinogen were registered. ADP mediated platelet aggregation and sedimentation rate were not modified. 24 h after carrageenin injection, sedimentation rate and blood fibrinogen were increased; some platelet hyperaggregation with ADP was also observed.
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D002351:Carrageenan; D007249:Inflammation / Q000097:blood* / Q000139:chemically induced; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats; D013997:Time Factors
chemical_list: D000244:Adenosine Diphosphate; D002351:Carrageenan