Renal and hepatic necrosis after metabolic activation of 2-substituted furans and thiophenes, including furosemide and cephaloridine.
D000818:Animals; D002509:Cephaloridine / Q000009:adverse effects* / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury; D005663:Furans / Q000009:adverse effects* / Q000378:metabolism; D005665:Furosemide / Q000009:adverse effects* / Q000378:metabolism; D066298:In Vitro Techniques; D007668:Kidney / Q000473:pathology; D007674:Kidney Diseases / Q000139:chemically induced* / Q000378:metabolism; D008099:Liver / Q000473:pathology; D008107:Liver Diseases / Q000378:metabolism; D008297:Male; D051379:Mice; D008861:Microsomes / Q000378:metabolism; D009336:Necrosis; D013876:Thiophenes / Q000009:adverse effects* / Q000378:metabolism
D005663:Furans; D013876:Thiophenes; D005665:Furosemide; D002509:Cephaloridine