Chlorinated benzene induction of hepatic porphyria.
1,4-Dichlorobenzene and 1,2,4-trichlorobenzene were compared with hexachlorobenzene which is known to cause porphyria. Although hexachlorobenzene administration resulted in a manyfold increase in liver porphyrin levels and urinary excretion of porphyrins, the lesser chlorinated compounds did not do so.
D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000652:urine*; D002722:Chlorobenzenes / Q000633:toxicity*; D005260:Female; D006581:Hexachlorobenzene / Q000633:toxicity; D008099:Liver / Q000187:drug effects; D009929:Organ Size / Q000187:drug effects; D011164:Porphyrias / Q000139:chemically induced* / Q000652:urine; D051381:Rats
D002722:Chlorobenzenes; D006581:Hexachlorobenzene