[Penetration of polyene antibiotics into human embryonic kidney tissue cell cultures].
Penetration of 14C-amphotericin AM-2 into the cells of the tissue culture of the human embryon kidneys was studied by means of light autoradiography after incubation with the antibiotic. Microscopic examination of the autographs of the cell slices revealed the presence of the radioactive label in the cytoplasm and nucleoplasm of the cells. The revealed intracellular localization of the label was evident of the antibiotic penetration into the cells.
D000666:Amphotericin B / Q000031:analogs & derivatives / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001345:Autoradiography; D002250:Carbon Radioisotopes; D002478:Cells, Cultured / Q000187:drug effects*; D003470:Culture Media; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D008854:Microscopy, Electron; D011090:Polyenes; D013997:Time Factors
D000900:Anti-Bacterial Agents; D002250:Carbon Radioisotopes; D003470:Culture Media; D011090:Polyenes; D000666:Amphotericin B
O proniknovenii polienovykh antibiotikov v kletki kul'tury tkani pochek émbriona cheloveka.