A comparative study of antipyrine pharmacokinetics in saliva and plasma using a colourimetric method of antipyrine analysis.
1. Half-life, apparent volume of distribution and metabolic clearance rate for antipyrine elimination were reliably estimated from either plasma or saliva samples. 2. Pharmacokinetic analysis of antipyrine from saliva utilizing a simple and sensitive colourimetric technique provided a convenient method for assessing the activity of hepatic microsomal drug-metabolizing enzymes.
D000328:Adult; D000983:Antipyrine / Q000097:blood / Q000378:metabolism*; D003124:Colorimetry; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D012463:Saliva / Q000378:metabolism*
D000983:Antipyrine