[Distribution volume and elimination of triamterene and its active metabolites in the rabbit (author's transl)].
In rabbits the volumes of distribution of triamterene (TA) and its metabolites hydroxytriamterene (OH-TA) and hydroxytriamterene sulfuric acid ester (OH-TA-ester) were determined after i.v. administration of the agents. Both TA as well as its metabolites distribute in at least 2 compartments, OH-TA exhibiting by far the greatest volume of distribution, followed by TA and then by OH-TA-ester. TA and its phase-II-metabolite are eliminated at practically equal rate, whereas the elimination of OH-TA is relatively slow.
D000818:Animals; D001711:Biotransformation; D008297:Male; D011817:Rabbits; D013997:Time Factors; D014223:Triamterene / Q000097:blood / Q000378:metabolism*
D014223:Triamterene
Verteilungsvolumen und Elimination von Triamteren und seinen wirksamen Metaboliten beim Kaninchen.