[Promoting and inhibitory influences of tribenoside and acetylsalicylic acid on spontaneous arthrosis in the mouse (author's transl)].
Tribenoside administered in moderate doses over periods of three or ten months, inhibited the development of spontaneous arthrosis in mice of the C 57 black strain. Acetylsalicylic acid administered once daily in oral doses of 50 and 150 mg/kg for five months, had a distinctly promoting effect on the development of the same arthrosis. Attention is drawn to certain common features in the activity spectra of the two drugs, but especially also to their opposite effects on mucopolysaccharide metabolism and on regenerative processes which are promoted by tribenoside but inhibited by acetylsalicylic acid.
D000284:Administration, Oral; D000818:Animals; D001241:Aspirin / Q000008:administration & dosage / Q000627:therapeutic use*; D006027:Glycosides / Q000008:administration & dosage / Q000627:therapeutic use*; D007592:Joint Diseases / Q000188:drug therapy*; D051379:Mice; D008810:Mice, Inbred C57BL; D013997:Time Factors
D006027:Glycosides; D001241:Aspirin
Fördernde und hemmende Einflüsse von Tribenosid und Acetylsalicylsäure auf die spontane Arthrose der Maus.