[Aldactone in the treatment of sarcoidosis of the lungs (author's transl)].
Earlier experimental findings and isolately clinical experiences too made to suppose spironolacton and their derivatives to have an immunosuppressive effect. Under this point of view and in connection with it the conception to apply cortisone in a combination as low as possible or even to avoid it al all, aldactone has been applied by way of trial in the therapy of the sarcoidosis of the lungs. After an experience over three years the therapeutical results are compared with the earlier treatment methods only basing on cortisone and the possible effective mechanism is discussed. Merely spontaneous regressions are not supposed to be in all cases showing a good therapeutical effect; the successful application of aldactone in the treatment of lung fibrosis is also speaking in favour of it.
D001706:Biopsy; D003348:Cortisone / Q000627:therapeutic use; D004357:Drug Synergism; D006801:Humans; D008171:Lung Diseases / Q000188:drug therapy* / Q000473:pathology; D012507:Sarcoidosis / Q000188:drug therapy* / Q000473:pathology; D013148:Spironolactone / Q000627:therapeutic use*
D013148:Spironolactone; D003348:Cortisone
Aldactone in der Behandlung der Lungensarkoidose.