title: [Experimental infection of mice, gerbils, and rats with mycoplasms from canine pericardium and cardial value (author's transl)].
abstract: Mycoplasms isolated from heart valves (A. laidlawii (A 42 Hzbtl)) and pericardium (M. canis (A 56 Hzkl)) of dogs were investigated for infectivity of rats, mice and gerbils (Meriones unguiculatus). In mice the species M. spumans (PG 13), M. maculosum (PG 15), M. edwardii (PG 24) and M. molare (H 542) were investigated too. The mycoplasmas were inoculated by oral, subcutaneous, intravenous and intraperitoneal route. Intraperitoneally the mycoplasmas were given without and with complete and incomplete Freund adjuvants. The injected Mycoplasmas did not produce any disease and could not be reisolated from rats and gerbils. From mice A. laidlawii (A 42 Hzbtl), M. canis (A 56 Hzkl) and M. edwardii (PG 24) could be reisolated after intraperitoneal administration in emulsion with complete and incomplete Freund adjuvants. Whereas M. canis (A 56 Hzkl) and M. edwardii (PG 24) could be reisolated from lung, liver and spleen only, A. laidlawii (A 42 Hzbtl) was present in heart muscle too. In histological investigations the mice which got A. laidlawii (A 42 Hzbtl) intraperitoneally with complete Freund adjuvants showed focal lymphocytic infiltrations in the myocardium.
mesh_terms: D000128:Acholeplasma laidlawii / Q000472:pathogenicity; D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D005849:Gerbillinae; D006351:Heart Valves / Q000382:microbiology*; D051379:Mice; D009174:Mycoplasma / Q000472:pathogenicity*; D009175:Mycoplasma Infections / Q000635:transmission*; D010496:Pericardium / Q000382:microbiology*; D051381:Rats
vernacular_title: Experimentelle Infektion von Mäusen, Gerbils und Ratten mit Mykoplasmen aus Herzbeutel und Herzklappe von Hunden.