Effect of a biguanide (buformin) on carnitine palmitoyltransferase activity.
Buformin at a concentration of 1--2.5 mM stimulates solubilized carnitine palmitoyltransferase by reducing the inhibitory effect of palmitoyl-CoA. Neither buformin nor metformin inhibits the solubilized carnitine palmitoyltransferase.
D000217:Acyltransferases / Q000378:metabolism*; D000818:Animals; D001645:Biguanides / Q000494:pharmacology*; D002026:Buformin / Q000494:pharmacology*; D002334:Carnitine O-Palmitoyltransferase / Q000378:metabolism*; D002417:Cattle; D007700:Kinetics; D008099:Liver / Q000201:enzymology; D013268:Stimulation, Chemical
D001645:Biguanides; D000217:Acyltransferases; D002334:Carnitine O-Palmitoyltransferase; D002026:Buformin