Relationship between the antitrichinellous effect of seven derivates of benzimidazolecarbamates and their chemical structure.
The efficacy of seven more recently developed anthelmintics of the benzimidazolecarbamate group, i. e., parbendazole, mebendazole, fenbendazole, oxibendazole, cambendazole, oxfendazole and albendazole, has been tested in a series of experiments on white mice artifically infected with Trichinella spiralis. Our results disclosed a relationship between their anthelmintic effect and their chemical structure. This finding might be of importance in a targeted synthesis of new, effective, derivates of benzimidazole, e. g., in the therapy of trichinellosis and in the choice of the most effective drug.
D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology* / Q000627:therapeutic use; D002159:Cambendazole / Q000494:pharmacology; D005273:Fenbendazole / Q000494:pharmacology; D008463:Mebendazole / Q000494:pharmacology; D051379:Mice; D013329:Structure-Activity Relationship; D014234:Trichinella / Q000187:drug effects*; D014235:Trichinellosis / Q000188:drug therapy
D001562:Benzimidazoles; D002159:Cambendazole; D005273:Fenbendazole; D008463:Mebendazole; C100292:parbendazole