[Insomnia in bismuth encephalopathy (author's transl)].
Myoclonic encephatopathy caused by the insoluble salts of bismuth may be accompanied by a state of total insomnia. This insomnia has been confirmed by polygraphic recordings in 3 subjects. The recovery of sleep has a stereotyped course, with a step-wise reappearance over time of sucessive stages of NREM sleeps tarting with stage age I, and parallel re-establishment of REM sleep. Return to normal sleep lags behind clinical recovery. A pharmacological analysis with the phobenecid test was attempted in 2 of the 3 subjects. The results were the same in both as regards renewal of lumbar 5 HIAA, which paradoxically is not changed much; as regards the rate of lumbar HVA renewal, the results were quite different.
D000328:Adult; D001729:Bismuth / Q000633:toxicity*; D001921:Brain / Q000378:metabolism; D001927:Brain Diseases / Q000139:chemically induced*; D004298:Dopamine / Q000378:metabolism; D004569:Electroencephalography; D005260:Female; D006212:Hallucinations / Q000139:chemically induced; D006801:Humans; D008297:Male; D008875:Middle Aged; D012701:Serotonin / Q000378:metabolism; D007319:Sleep Initiation and Maintenance Disorders / Q000139:chemically induced* / Q000503:physiopathology
D012701:Serotonin; D001729:Bismuth; D004298:Dopamine
L'insomnie de l'encéphalopathie bismuthique.