Hypoglycin stimulates insulin secretion.
Hypoglycin A(0.01--1.0 mmol/l) stimulated insulin release from pieces of rabbit pancreas in vitro in the presence or absence of extracellular glucose. The relevance of this finding to the hypoglycaemia of Jamaican vomiting sickness is discussed.
D000818:Animals; D003521:Cyclopropanes / Q000494:pharmacology*; D005947:Glucose / Q000494:pharmacology; D007005:Hypoglycins / Q000494:pharmacology*; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism*; D011817:Rabbits
D003521:Cyclopropanes; D007005:Hypoglycins; D007328:Insulin; D005947:Glucose