title: Combined intravenous miconazole and intrathecal amphotericin B for treatment of disseminated coccidioidomycosis.
abstract: A patient received a previously unreported combination of intravenous miconazole and intrathecal amphotericin B for the treatment of disseminated coccidioidomycosis with central nervous system involvement. After first having been treated with amphotericin B, followed by a course of miconazole therapy, the patient responded with remarkable clinical and serologic improvement to the combination of intrathecal amphotericin B and intravenous miconazole. The combination should be considered in the treatment of disseminated coccidioidomycosis with central nervous system involvement.
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage*; D002908:Chronic Disease; D003047:Coccidioidomycosis / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage*; D007275:Injections, Intravenous; D007278:Injections, Spinal; D008297:Male; D008825:Miconazole / Q000008:administration & dosage*
chemical_list: D007093:Imidazoles; D008825:Miconazole; D000666:Amphotericin B