Cytosine arabinoside binding to human plasma proteins.
The interaction of cytosine arabinoside (Ara-C) with human plasma proteins was investigated by means of ultrafiltration and ultracentrifugation. The results obtained with both methods did not differ significantly. Ara-C binding was studied at plasma levels within the therapeutic range (0.005-1.0 mg/l). It appeared that 13.3% (SD: 2.2%) of Ara-C in the plasma was bound to proteins. The percentage of bound drug was independent of the drug concentration, at least in the therapeutic range.
D001798:Blood Proteins / Q000378:metabolism*; D003561:Cytarabine / Q000097:blood*; D006801:Humans; D011485:Protein Binding; D014461:Ultracentrifugation; D014462:Ultrafiltration
D001798:Blood Proteins; D003561:Cytarabine