[The behaviour of codeine and codeine-6-glucuronide in hydrolysis with hydrochloric acid (author's transl)].
The behaviour of codeine and codeine-6-glucuronide with hydrochloric acid has been investigated. Three methods of hydrolysis were selected; they are often used in routine identification of drugs in urine. With method I (12--13% HCl; 30 min at 100 degrees C) about 53% of codeine-6-glucuronide were not hydrolized. The corresponding values: with method II (20% HCl; 6 min heated azeotrope in open vessel) about 8% and with method III (nearly 5% HCl; 30 min at 100 degrees C) about 83%.
D055598:Chemical Phenomena; D002621:Chemistry; D002855:Chromatography, Thin Layer; D003061:Codeine / Q000032:analysis*; D005965:Glucuronates / Q000032:analysis; D006851:Hydrochloric Acid; D006868:Hydrolysis; D008722:Methods; D013056:Spectrophotometry, Ultraviolet
D005965:Glucuronates; D006851:Hydrochloric Acid; D003061:Codeine
Verhalten von Codein und Codein-6-glucuronid bei der Hydrolyse mit Salzsäure.