The HLA B w4/w6 diallelic system in Graves' disease.
We studied the diallelic system HLA--Bw4/w6 in patients with Graves' disease and control subjects. Twenty-one out of the 22 patients with Graves' disease were found to be HLA--Bw6 positive and 16 of these were homozygous, contrasted with 28 and 9 out of 34 controls, respectively. HLA--Bw6 positivity results in a relative risk for Graves' disease of 3.27; homozygosity for that allele further increases the risk to 7.4. It is possible that the increased risk attached to HLA--Bw6 is secondary to the increase in HLA--B8 previously described in Graves' disease.
D000483:Alleles; D006111:Graves Disease / Q000235:genetics* / Q000276:immunology; D006680:HLA Antigens / Q000032:analysis; D006238:Haploidy; D006801:Humans; D010641:Phenotype
D006680:HLA Antigens