title: Present status of chymopapain and chemonucleolysis.
abstract: An analysis of recent events and newly published data on Chymopapain and the technique of Chemonucleolysis including an objective analysis of clinical and basic research as well as the circumstances leading to the FDA curtailment of the use of Chymopapain in the United States, indicate that the drug should be reapproved for investigational use.
mesh_terms: D002917:Chymopapain / Q000627:therapeutic use*; D010450:Endopeptidases / Q000627:therapeutic use*; D006801:Humans; D007403:Intervertebral Disc / Q000187:drug effects*; D007405:Intervertebral Disc Displacement / Q000628:therapy; D013122:Spinal Diseases / Q000628:therapy*; D014481:United States; D014486:United States Food and Drug Administration
chemical_list: D010450:Endopeptidases; D002917:Chymopapain