Arsenate-induced renal agenesis in rats.
The developmental origin of arsenate-induced renal agenesis was investigated. Pregnant Wistar rats were each injected once ip with 45 mg/kg sodium arsenate at day 10 (sperm day = day 0). Pregnancy was terminated at various times following injection and the embryos recovered and serially sectioned. Renal agenesis resulted when the mesonephric duct failded to give rise to a ureteric bud with subsequent failure of induction of the metanephric blastema. The underlying defect was retardation in growth of the mesonephric duct, first observed 48 hours after arsenate injection. A shortened mesonephric duct also resulted in a failure of the mesonephros to attain normal size and in the male resulted in absence of the ductus deferens, seminal vesicle a variable portion of the epididymis. Due to the intimate association of the mesonephric and growing paramesonephric ducts, a shortened mesonephric duct resulted in a shortened paramesonephric duct with resultant lack of a uterine horn.
D000014:Abnormalities, Drug-Induced / Q000196:embryology*; D000818:Animals; D001149:Arsenates / Q000633:toxicity*; D001151:Arsenic / Q000633:toxicity*; D005260:Female; D005327:Fetal Resorption / Q000139:chemically induced; D005835:Genitalia / Q000002:abnormalities; D005865:Gestational Age; D007668:Kidney / Q000002:abnormalities*; D008297:Male; D011247:Pregnancy; D051381:Rats; D013997:Time Factors; D014564:Urogenital Abnormalities
D001149:Arsenates; D001151:Arsenic