The role of the responsiveness of animal stock to certain secretagogues in evaluating antisecretory drugs. Experiments in the lumen-perfused rat.
The gastric secretion pattern resulting from histamine, pentagastrin and carbachol infusion was studied in lumen-perfused anesthetised male Wistar rats. The differences between the results of this study and other published results and among the latter demonstrate the necessity of knowing the acid secretion patterns in given laboratory conditions before attempting to assess the antisecretory activity of any drug.
D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D005750:Gastric Juice / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology; D008297:Male; D010418:Pentagastrin / Q000494:pharmacology; D051381:Rats; D012636:Secretory Rate / Q000187:drug effects
D006632:Histamine; D002217:Carbachol; D010418:Pentagastrin