Long acting methadone formulation. Part 3: Preparation and in vivo evaluation of tablets containing methadone salts and methadone-naloxone combinations.
The preparation and in vivo evaluation of the methadone salts, methadone-o-benzoylbenzoate and methadone-alpha-naphthalenesulfonate, and a number of methadone-naloxone formulations, in the form of three layered slowly eroding tablets, were examined. Male albino rats of the Wistar strain were used as experimental animals and the results indicated that a prolongation of the resistance to pain threshold was attained, though severe side-effects were observed. A number of animals died during these experimental procedures.
D000818:Animals; D003692:Delayed-Action Preparations; D004338:Drug Combinations; D004339:Drug Compounding; D008297:Male; D008691:Methadone / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D013607:Tablets; D013997:Time Factors
D003692:Delayed-Action Preparations; D004338:Drug Combinations; D013607:Tablets; D009270:Naloxone; D008691:Methadone