[Effect of carbon disulfide on peripheral blood leukocytes. I. Effect of carbon disulfide on in vitro chromosome structure and division capability of leukocytes in man].
The peripheral blood leukocytes in normal subjects were cultured according to Moorhead with addition of CS2 (0,75 microliter/ml of culture). It has been found that CS2 decreases the mitotic index, and in some cultures inhibits totally the cell division. Moreover, it causes structural disturbances of chromosomes being of pre- and postreplicative character as well as their viscous degeneration, lesser spiralization and sometimes pulverization. The presence of greater amount of erythrocytes of the donor's blood in the culture markedly diminished the intensity of these changes.
D000293:Adolescent; D000328:Adult; D002246:Carbon Disulfide / Q000009:adverse effects*; D002455:Cell Division / Q000187:drug effects; D002869:Chromosome Aberrations; D006801:Humans; D007962:Leukocytes / Q000187:drug effects*
D002246:Carbon Disulfide
Wpływ dwusiarczku wegla na leukocyty krwi obwodowej. I. Wpływ dwusiarczku wegla in vitro na strukture chromosomów i zdolność poddziałowa leukocytow człowieka.