Binding study of benzamides to serum albumins by fluorescence probe technique.
The interaction between human and bovine serum albumins (HSA and BSA) were studied with two derivatives of benzamide, metoclopramide (Primpéran) and sultopride (Barnétil). It was possible to evaluate association constants (K ass.) characterising this interaction by fluorescence probe technique inspite of the very low binding tendency, which can be correlated to pharmacokinetic properties of these drugs.
D000818:Animals; D001549:Benzamides / Q000097:blood*; D001665:Binding Sites; D002417:Cattle; D007700:Kinetics; D008787:Metoclopramide / Q000097:blood; D011485:Protein Binding; D012710:Serum Albumin, Bovine / Q000378:metabolism*; D013050:Spectrometry, Fluorescence; D013469:Sulpiride / Q000031:analogs & derivatives / Q000097:blood
D001549:Benzamides; D012710:Serum Albumin, Bovine; D013469:Sulpiride; D008787:Metoclopramide