A comparison of the effects of prednisolone and methylprednisolone on human lymphoblastoid cells.
Methylprednisolone is more effective than prednisolone in mediating long-term cytolysis and immediate inhibition of nucleoside uptake in human lymphoblastoid cells. This suggests that methylation of prednisolone makes it more potent by aiding interaction with a cellular target rather than increasing its stability.
D002051:Burkitt Lymphoma / Q000378:metabolism; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D007938:Leukemia / Q000378:metabolism; D008214:Lymphocytes / Q000187:drug effects*; D008775:Methylprednisolone / Q000494:pharmacology*; D011239:Prednisolone / Q000494:pharmacology*; D014529:Uridine / Q000378:metabolism
D011239:Prednisolone; D014529:Uridine; D008775:Methylprednisolone