[Biosynthesis of corriphyrins - a new branch of metabolism of tetrapyrrole compounds].
Experiments were carried out to study biosynthesis of tetrapyrrole pigments--corriphyrins which are methylated reduced derivatives of uroporphyrin III. It was shown that the pattern of corriphyrin synthesis was close to that of vitamin B12. The mutant strain of propionic bacteria which was active in the vitamin B12 formation synthesized significantly more corriphyrins than the original strain. The corriphyrin synthesis was stimulated by delta-aminolevulinic acid and methionine and was inhibited by hydroxylamine and aeration. The formation of corriphyrins was repressed by vitamin B12. It is concluded that corriphyrins are precursors of vitamin B12 at the stage between uroporphyrinogene III and cobyrinic acid. The paper discusses further investigations of metabolism of methylated derivatives of uroporphyrinogene III as a method of elucidating the evolution of tetrapyrrole compounds and clarifying the processes involved in porphyrin metabolism in higher plants and animals.
D000332:Aerobiosis; D000622:Aminolevulinic Acid / Q000494:pharmacology; D006898:Hydroxylamines / Q000494:pharmacology; D008715:Methionine / Q000494:pharmacology; D011166:Porphyrins / Q000378:metabolism*; D011424:Propionibacterium / Q000187:drug effects / Q000378:metabolism*; D011758:Pyrroles / Q000378:metabolism*; D013045:Species Specificity
D006898:Hydroxylamines; D011166:Porphyrins; D011758:Pyrroles; D000622:Aminolevulinic Acid; D008715:Methionine
Biosintez korrifirinov - novaia vetv' metabolizma tetrapirrol'ykh soedineniĭ.