Increased feeding in response to bilateral injection of insulin antibodies in the VMH.
In order to investigate the role of insulin in the VMH in regulation of food intake in the rat, a specific antibody against rat insulin was injected in the VMH. The insulin antibody caused transient hyperphagia, when administered in the nighttime. This result is discussed in view of the glucostatic theory of the regulation of food intake.
D000818:Animals; D000906:Antibodies; D001786:Blood Glucose / Q000378:metabolism; D002940:Circadian Rhythm; D004435:Eating; D007031:Hypothalamus / Q000502:physiology*; D007033:Hypothalamus, Middle / Q000378:metabolism / Q000502:physiology*; D007328:Insulin / Q000276:immunology* / Q000378:metabolism; D008297:Male; D051381:Rats; D011930:Reaction Time; D011955:Receptors, Drug / Q000502:physiology
D000906:Antibodies; D001786:Blood Glucose; D007328:Insulin; D011955:Receptors, Drug