title: Immunosuppression in murine malaria. II. The primary response to bovine serum albumin.
abstract: The primary antibody response to alumadsorbed bovine serum albumin was depressed in CBA mice infected with Plasmodium yoelii yoelii. Responses initiated within approximately 3 weeks of this malaria infection were reduced in quantity, but not in avidity. Responses initated later were normal. A depressed primary response was also seen in infected compared to control splenectomized mice; this was accompanied by impaired  priming for a secondary response.
mesh_terms: D000208:Acute Disease; D000534:Alum Compounds; D000818:Animals; D000917:Antibody Formation; D001666:Binding Sites, Antibody; D002417:Cattle; D005260:Female; D007156:Immunologic Memory; D007164:Immunosorbents; D007165:Immunosuppression Therapy; D008288:Malaria / Q000276:immunology*; D051379:Mice; D008808:Mice, Inbred CBA; D012710:Serum Albumin, Bovine / Q000276:immunology*; D013156:Splenectomy
chemical_list: D000534:Alum Compounds; D007164:Immunosorbents; D012710:Serum Albumin, Bovine