title: Intramolecular base composition heterogeneity of human DNA.
abstract: The intramolecular base composition heterogeneity of human DNA has been investigated by electron microscopic observations of partially denatured structures and by equilibrium solution thermal denaturation techniques. DNA sequences having an average length of less than 2000 base pairs are found to be heterogeneous in base composition. These heterogeneous sequences occupy a minimum of 67 to 81% of the human genome.
mesh_terms: D001483:Base Sequence; D004247:DNA / Q000032:analysis; D003854:Deoxyribonucleotides / Q000032:analysis; D005559:Formamides / Q000494:pharmacology; D006358:Hot Temperature; D006801:Humans; D008970:Molecular Weight; D009691:Nucleic Acid Denaturation / Q000187:drug effects
chemical_list: D003854:Deoxyribonucleotides; D005559:Formamides; D004247:DNA