title: [Morphologic and histochemical responses of the body to introduction of C1. botulinum toxin. V. Response of locus coeruleus cells of the brain to introduction of the toxin of C1. botulinum type B].
abstract: After the per os administration of 1Dlm/ml of botulin, type B. there were observed at the period of development of the limb paralysis and myasthenia morphological changes in the locus coeruleus cells expressed in the development of a more pronounced than normal perinuclear clarification and some nuclear basophilia. Histochemical study of succinic dehydrogenase, acid phosphatase, cholinesterase, and catecholamines pointed to the intensified neuron metabolism of the locus coeruleus; this could serve as an indication of enhanced energopacemaker function of this nucleus in hypoxia which occurred.
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D001905:Botulinum Toxins / Q000506:poisoning*; D002395:Catecholamines / Q000378:metabolism; D002802:Cholinesterases / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D006168:Guinea Pigs; D006651:Histocytochemistry; D008125:Locus Coeruleus / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D012313:RNA / Q000378:metabolism; D013385:Succinate Dehydrogenase / Q000378:metabolism
chemical_list: D002395:Catecholamines; D012313:RNA; D004247:DNA; D013385:Succinate Dehydrogenase; D002802:Cholinesterases; D000135:Acid Phosphatase; D001905:Botulinum Toxins
vernacular_title: Morfologicheskaia i gistokhimicheskaia kharakteristika reaktsiĭ organizma na vvedenie toksina C1. botulinum. Soobshchenie V. Reaktsiia kletok sinego piatna (locus coeruleus) mozga na vvedenie toksina C1. botulinum tipa B.