Measurement of thyroid hormone in experimental thyroid tumours in rats.
Rats treated with 131I and propylthiouracil were shown to develop thyroid tumours 7--9 months after treatment. In this group, the levels of total thyroxine and tri-iodothyronine, and free thyroxine and tri-iodothyronine in the serum were low, and that of TSH was raised. In a group of rats treated with 131I and then propylthiouracil and thyroxine, thyroid tumours were found despite normal concentrations of total and free thyroxine and tri-iodothyronine in the serum. The level of TSH in the serum was significantly raised in this group. Thyroid tumours were not found in the various control groups of rats.
D000818:Animals; D007457:Iodine Radioisotopes; D008297:Male; D009374:Neoplasms, Experimental / Q000097:blood; D011441:Propylthiouracil; D051381:Rats; D013964:Thyroid Neoplasms / Q000097:blood* / Q000139:chemically induced; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000097:blood*; D014284:Triiodothyronine / Q000097:blood*
D007457:Iodine Radioisotopes; D014284:Triiodothyronine; D011441:Propylthiouracil; D013972:Thyrotropin; D013974:Thyroxine