Sulfobromophthalein and indocyanine green binding by the hepatic cytoplasmic proteins.
The elution patterns of human and rat liver supernate mixed with BSP or ICG have been demonstrated using G-100 Sephadex gel filtration. The elution pattern in the rat liver remained the same as that shown by Levi et al. In the human liver BSP localized to Y protein could hardly be demonstrated, whereas ICG was detected. This pattern was quite similar in Rotor's hyperbilirubinemia and in Crigler-Najjar syndrome Type II. These observations suggest that the impaired hepatic transportation of organic anions in congenital hyperbilirubinemias may not be related to cytoplasmic organic anion-binding proteins.
D000818:Animals; D003593:Cytoplasm / Q000032:analysis*; D006801:Humans; D006932:Hyperbilirubinemia / Q000378:metabolism; D007208:Indocyanine Green / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D013448:Sulfobromophthalein / Q000378:metabolism*
D011506:Proteins; D013448:Sulfobromophthalein; D007208:Indocyanine Green