[Absence of a teratogenic effect of sodium nitroprusside in wistar rats and rabbits (author's transl)].
In a series of experiments sodium nitroprusside (NNP) was tested in the prenatal phases of development in two animal species with regard to possible teratogenic and embryo-toxic effects. A total of 571 offsprings of rats and 48 offsprings of rabbits was investigated. The application of NNP in the prenatal experiment produced no evidence of an embryo-toxic or teratogenic effect, respectively, in rats and rabbits.
D000818:Animals; D004622:Embryo, Mammalian / Q000187:drug effects; D005260:Female; D005292:Ferricyanides / Q000633:toxicity*; D007928:Lethal Dose 50; D008297:Male; D009599:Nitroprusside / Q000633:toxicity*; D011247:Pregnancy; D011817:Rabbits; D051381:Rats; D013723:Teratogens
D005292:Ferricyanides; D013723:Teratogens; D009599:Nitroprusside
Fehlende teratogene Wirkung von Nitroprussidnatrium (NNP) an Wistar-Ratten und Kaninchen.