Gaze failure, drifting eye movements, and centripetal nystagmus in cerebellar disease.
Three abnormalities of eye movement in man are described which are indicative of cerebellar system disorder, namely, centripetally beating nystagmus, failure to maintain lateral gaze either in darkness or with eye closure, and slow drifting movements of the eyes in the absence of fixation. Similar eye movement signs follow cerebellectomy in the primate and the cat. These abnormalities of eye movement, together with other signs of cerebellar disease, such as rebound alternating, and gaze paretic nystagmus, are explained by the hypothesis that the cerebellum helps to maintain lateral gaze and that brain stem mechanisms which monitor gaze position generate compensatory biases in the absence of normal cerebellar function.
D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000503:physiopathology; D002524:Cerebellar Ataxia / Q000503:physiopathology; D002526:Cerebellar Diseases / Q000503:physiopathology*; D002561:Cerebrovascular Disorders / Q000503:physiopathology; D002648:Child; D005133:Eye Movements; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000503:physiopathology; D009759:Nystagmus, Pathologic / Q000503:physiopathology