19-Hydroxy-prostaglandin E and infertility in human males.
We measured the content of 19-hydroxy-prostaglandin E (19-OH-PGE) and prostaglandin E (PGE) in the semen of 10 infertile males by alkaline dehydration, thin layer chromatographic separation and ultraviolet spectrophotometry. 7 fertile males were also studied. In both groups the content of seminal 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha) also was measured by thin layer chromatographic separation and highly specific radioimmunoassay. The amounts of 19-OH-PGE and PGE were significantly lower (p < .02, p < .05) in the infertile group than the fertile group. Differences in mean seminal 6-keto-F1 alpha were not significant. The uterine stimulatory actions of 19-OH-PGE demonstrable in the monkey may apply to fertility in man.
D015121:6-Ketoprostaglandin F1 alpha; D000527:Alprostadil / Q000031:analogs & derivatives*; D002855:Chromatography, Thin Layer; D006801:Humans; D007248:Infertility, Male / Q000378:metabolism*; D008297:Male; D011458:Prostaglandins E / Q000032:analysis*; D011460:Prostaglandins F / Q000032:analysis; D012661:Semen / Q000032:analysis*; D013076:Sperm Count
D011458:Prostaglandins E; D011460:Prostaglandins F; C025128:19-hydroxyprostaglandin E1; D015121:6-Ketoprostaglandin F1 alpha; D000527:Alprostadil