title: [Determination and comparison of the plasma and urine concentrations in men given tranylcypromine stereoisomers].
abstract: The (+) and (-)isomers of DL-trans-2-phenylcyclopropylamine (tranylcypromine, Parnate, Jatrosom) were tested under cross-over conditions on 10 volunteers. (-)Tranylcypromine entered blood circulation more rapidly, reached significantly higher concentrations and was metabolized more slowly than (+)tranylcypromine. These results indicate a difference in the pharmacokinetics of the tranylcypromine isomers. In the urine collected over a period of 24 h the excretion of unmetabolized (4)tranylcypromine was lower probably resulting from the greater metabolization rate of this isomer. There is a conformity between the findings in plasma and urine.
mesh_terms: D000328:Adult; D006801:Humans; D007700:Kinetics; D008297:Male; D013237:Stereoisomerism; D013997:Time Factors; D014191:Tranylcypromine / Q000097:blood / Q000378:metabolism* / Q000652:urine
chemical_list: D014191:Tranylcypromine
vernacular_title: Bestimmung und Vergleich der Plasma- und Urinkonzentrationen nach Gabe von (+)- und (-)-Tranylcypromin.