RNA-RNA hybridization between influenza viruses.
A study is described of the RNAs of recombinant viruses made from A/PR/8/34, which is non-infectious for man, and wild human Influenza A strains. By RNA-RNA hybridization it was possible to determine the proportion of the genome donated by each of the parents. The technique can be applied as a biochemical marker to detect the recombinants among parental viruses and moreover, it is a method to select the attenuated viruses among the recombinants.
D000917:Antibody Formation; D006801:Humans; D009980:Influenza A virus / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D012367:RNA, Viral / Q000235:genetics*; D011995:Recombination, Genetic; D014613:Vaccines, Attenuated
D012367:RNA, Viral; D014613:Vaccines, Attenuated