[Local ventricular wall motion, local myocardial flow, and blood flow distribution in a poststenotic myocardial region in patients with coronary heart disease (author's transl)].
In 10 patients with coronary heart disease, local ventricular wall motion, local poststenotic flow, and distribution of myocardial perfusion were determined in the underperfused myocardium before and after 8 mg of Oxyfedrin intravenously. In 8 of the 10 patients there was a uniform reaction consisting of an improvement of wall motion, increase in flow, and homogeneity of flow distribution. These parallel changes of local wall movement and local blood flow in a poststenotic underperfused part of the myocardium can most probably be explained by the positively inotropic action of Oxyfedrin with a consecutive increase in blood flow. The results show that a therapeutic affect in patients with a coronary stenosis less than 60% in the left descending artery can be obtained with a positively inotropic substance.
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D003251:Constriction, Pathologic / Q000503:physiopathology; D003327:Coronary Disease / Q000503:physiopathology*; D003331:Coronary Vessels / Q000503:physiopathology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects; D010099:Oxyfedrine / Q000494:pharmacology; D012039:Regional Blood Flow / Q000187:drug effects
D010099:Oxyfedrine
Lokale Ventrikelwandfunktion, lokaler myokardialer Fluss und lokale Flussverteilung unter Oxyfedrin) in poststenotischen Myokardregionen.