title: The invasive pituitary adenoma. A prolactin-producing tumor.
abstract: Invasive pituitary adenoma was diagnosed by means of a transnasal aspiration biopsy method in 11 patients with extensive destruction of bone in the sellar region. In most cases the initial symptoms were decrease of libido and potency or amenorrhea-galactorrhea. Later, chiasmatic compression developed in six patients, ocular motor signs in two, and epilepsy in two. Most of the patients had symptoms for many years; in two, the tumor was discovered by chance. They all had very high serum-prolactin values. The patients were treated with irradiation, and the prognosis seems to be relatively favorable.
mesh_terms: D000236:Adenoma / Q000175:diagnosis / Q000378:metabolism* / Q000503:physiopathology; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000503:physiopathology; D011388:Prolactin / Q000096:biosynthesis*
chemical_list: D011388:Prolactin