[32P-incorporation in adenosine phosphates of the rat brain after oral application of vincamine for 2 weeks (author's transl)].
The 32P-incorporation into the adenosine phosphates AMP, ADP and ATP of the rat brain after an oral administration of a daily dose of 20 mg/kg 14,15-dihydro14 beta-hydroxy-(3 alpha,16 alpha)-eburnamenine-14-carbonic acid methylester (vincamine; Vincapront) during two weeks was determined. The concentrations of the three adenosine phosphates did not change. After the administration of vincamine the increase in the 32P-incorporation into AMP and ADP was statistically significant. The results obtained are discussed in regard to an acceleration of the pentose phosphate shunt and an activation of adenylate kinase.
D000227:Adenine Nucleotides / Q000378:metabolism*; D000244:Adenosine Diphosphate / Q000378:metabolism; D000249:Adenosine Monophosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D010761:Phosphorus Radioisotopes; D051381:Rats; D014748:Vinca Alkaloids / Q000494:pharmacology*; D014749:Vincamine / Q000494:pharmacology*
D000227:Adenine Nucleotides; D010761:Phosphorus Radioisotopes; D014748:Vinca Alkaloids; D000249:Adenosine Monophosphate; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D014749:Vincamine
Der 32P-Einbau in Adenosinphosphate des Rattengehirns nach 2wöchiger oraler Verabreichung von Vincamin.