[Quipazine antagonizing baclofen activity. Influence of baclofen and gamma-hydroxybutyric acid on serotonin metabolism in rat brain (author's transl)].
Baclofen increases the concentration of serotonin (5-HT) and 5-hydroxyindolacetic acid (5-HIAA) in the rat c. striatum without causing concomitant increase in 5-HT biosynthesis. The effect of baclofen on 5-HIAA, but not that on 5-HT, was antagonized dose-dependently by quipazine. It is assumed that quipazine acts by stimulating 5-HT autoreceptors.
D000613:Aminobutyrates / Q000037:antagonists & inhibitors*; D000818:Animals; D001418:Baclofen / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D003342:Corpus Striatum / Q000378:metabolism; D006885:Hydroxybutyrates / Q000494:pharmacology*; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D011804:Quinolines / Q000494:pharmacology*; D011814:Quipazine / Q000494:pharmacology*; D051381:Rats; D012701:Serotonin / Q000096:biosynthesis / Q000378:metabolism*
D000613:Aminobutyrates; D006885:Hydroxybutyrates; D011804:Quinolines; D012701:Serotonin; D011814:Quipazine; D006897:Hydroxyindoleacetic Acid; D001418:Baclofen
Antagonismus der Baclofenwirkung durch Quipazin. Beeinflussung des Serotoninstoffwechsels im Rattenhirn durch Baclofen und gamma-Hydroxybuttersäure.