title: Decreased antibody response following immunization with enantiomorphic synthetic polypeptides.
abstract: The ability to decrease the antibody response to poly(Glu52Lys33Tyr15) in the DA and PVG strains of rats by prior immunization with its D-amino acid enantiomorph poly(DGlu48DLys38DTyr14) was tested as part of a continuing investigation into the role of optical isomerism in the ability of an antigen to induce an antibody response. The results showed that prior immunization with the D-amino acid polymer decreased the immune response to the isomeric L-polypeptide in both strains.
mesh_terms: D000818:Animals; D000917:Antibody Formation; D007114:Immunization; D007536:Isomerism; D010455:Peptides / Q000276:immunology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D010455:Peptides