Hypoglycemic activity of amine derivatives. Preliminary observations.
Dicyclohexylamine and related amino compounds as well as some simple secondary amines with branched aliphatic substituents were found to decrease blood glucose levels of fasted, glucose-loaded, or streptozotocin-diabetic rats, and of fasted mice. Structure-activity relationships are discussed.
D000588:Amines / Q000494:pharmacology*; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000097:blood; D005260:Female; D005951:Glucose Tolerance Test; D007004:Hypoglycemic Agents; D008297:Male; D051379:Mice; D051381:Rats; D013329:Structure-Activity Relationship
D000588:Amines; D007004:Hypoglycemic Agents