[The Stockholm preoperative radiotherapy of operable breast cancer. Preliminary report].
The 4 year results of a prospective clinical trial on the treatment of operable breast cancer, comparing the effects of preoperative radiotherapy followed by surgery with those of surgery followed or not by postoperative radiotherapy are presented for patient groups of approximately 100 each. At 4 years 85 per cent survive after preoperative radiotherapy plus surgery, as against 77 per cent after surgery only and 81 per cent after surgery plus postoperative radiotherapy. These differences are not statistically significant. The incidence of local recurrence after radiotherapy was reduced to 1/4 of that seen after surgery only. The radiation could be shown to induce temporary damage in a number of immunological parameters. No correlation could be demonstrated between these findings and the clinical course of the disease.
D001943:Breast Neoplasms / Q000276:immunology / Q000532:radiotherapy* / Q000601:surgery; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods; D009364:Neoplasm Recurrence, Local; D011182:Postoperative Care; D011183:Postoperative Complications / Q000209:etiology; D011300:Preoperative Care; D011832:Radiation Injuries / Q000209:etiology; D011878:Radiotherapy / Q000009:adverse effects
L'essai de Stockholm de radiothérapie pré-opératoire dans le cancer du sein opérable. Rapport préliminaire.