title: Relationship between the antitrichinellous effect of seven derivates of benzimidazolecarbamates and their chemical structure.
abstract: The efficacy of seven more recently developed anthelmintics of the benzimidazolecarbamate group, i. e., parbendazole, mebendazole, fenbendazole, oxibendazole, cambendazole, oxfendazole and albendazole, has been tested in a series of experiments on white mice artifically infected with Trichinella spiralis. Our results disclosed a relationship between their anthelmintic effect and their chemical structure. This finding might be of importance in a targeted synthesis of new, effective, derivates of benzimidazole, e. g., in the therapy of trichinellosis and in the choice of the most effective drug.
mesh_terms: D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology* / Q000627:therapeutic use; D002159:Cambendazole / Q000494:pharmacology; D005273:Fenbendazole / Q000494:pharmacology; D008463:Mebendazole / Q000494:pharmacology; D051379:Mice; D013329:Structure-Activity Relationship; D014234:Trichinella / Q000187:drug effects*; D014235:Trichinellosis / Q000188:drug therapy
chemical_list: D001562:Benzimidazoles; D002159:Cambendazole; D005273:Fenbendazole; D008463:Mebendazole; C100292:parbendazole