Absorption and excretion of 3H-raubasine in human subjects and dogs.
The pharmacokinetic behavior of (3,5,6-3H)-raubasine (RAU) was investigated in human subjects after oral administration and in dogs after both intravenous and oral administration. By the oral route RAU peak plasma levels appeared in human subjects after 1 h and in dogs after 2 h. Three-day cumulative urinary excretion was 22% by i.v. route and 13% by oral route in dogs, being 29% in human subjects after oral administration. Three-day cumulative faecal excretion in dogs was 51% by i.v. route and 57% by oral route whilst it was 24% in humans. From a comparison between the urinary excretion values observed after i.v. and oral administration, a RAU intestinal absorption of 59% may be obtained.
D000284:Administration, Oral; D000818:Animals; D004285:Dogs; D005243:Feces / Q000032:analysis; D006801:Humans; D007275:Injections, Intravenous; D007408:Intestinal Absorption; D013045:Species Specificity; D015016:Yohimbine / Q000008:administration & dosage / Q000378:metabolism*
D015016:Yohimbine