New antitumor antibiotics, OS-4742 A1, A2, B1 and B2 produced by a strain of Streptomyces.
New antibiotics, OS-4742 A1, A2, B1 and B2, were isolated from the culture broth of the strain OS-4742, which was designated as Streptomyces matensis subsp. vineus. These compounds have anthracycline chromophores and sugar moieties, but do not contain nitrogen. They possess antimicrobial activities against Gram-positive bacteria and antitumor activities against S-180 solid tumor on mice.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000302:isolation & purification; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D055598:Chemical Phenomena; D002621:Chemistry; D051379:Mice; D012510:Sarcoma 180 / Q000188:drug therapy*; D013302:Streptomyces / Q000378:metabolism* / Q000502:physiology
D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic