Studies on regional inhibition of carbonic anhydrase by sulpiride in rat brain.
Sulpiride is an antipsychotic which possesses the free sulfonamide radical. From the viewpoint of this phenomenon, the in vitro inhibitory effect of sulpiride on carbonic anhydrase (CAH) was investigated. CAH inhibition was studied in eleven regions of the rat brain. The distribution of sulpiride was estimated on the basis of these findings.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D002257:Carbonic Anhydrase Inhibitors; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D013469:Sulpiride / Q000378:metabolism / Q000494:pharmacology*
D002257:Carbonic Anhydrase Inhibitors; D013469:Sulpiride