The effect of digoxin on endothelaemia in rats and its modification by a combination of troxerutin and coumarin.
The effect of digoxin on endothelium was tested with the method based on counting of circulating endothelial cells in rats. Digoxin in low doses had a protective and in high doses a damaging effect on endothelium. The latter effect was effectively suppressed by a concomitant administration of a combination of troxerutin and coumarin (Venalot).
D000818:Animals; D003374:Coumarins / Q000494:pharmacology*; D004077:Digoxin / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004727:Endothelium / Q000187:drug effects*; D006896:Hydroxyethylrutoside / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D012431:Rutin / Q000031:analogs & derivatives*; D013997:Time Factors
D003374:Coumarins; D006896:Hydroxyethylrutoside; D012431:Rutin; D004077:Digoxin