Microfluorometric investigations on the cell cycle progression of experimental ascites tumors treated with alkaloidic drugs.
The effects of the antitumor agents vincristine (VCR) and vincaleucoblastine (VLB) on the cell cycle progression of three different ascites tumor cell lines in vivo (Ehrlich, Crocker S 180, and leukemia L 1210) were studied in detail by flow microfluorometric techniques over a 5-day period of drug treatment and during the post-treatment course. These investigations give evidence that the tumor lines employed show completely different sensitivity against VCR and VLB. During the treatment massive polyploidization was demonstrated to be, in general, the second response of treated cells overcoming an initial proliferative block in the G 2 phase of their life cycle.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D002453:Cell Cycle / Q000187:drug effects*; D004273:DNA, Neoplasm / Q000378:metabolism; D005470:Fluorometry / Q000379:methods; D007939:Leukemia L1210 / Q000188:drug therapy; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D012510:Sarcoma 180 / Q000188:drug therapy; D014747:Vinblastine / Q000494:pharmacology; D014748:Vinca Alkaloids / Q000494:pharmacology*; D014750:Vincristine / Q000494:pharmacology
D004273:DNA, Neoplasm; D014748:Vinca Alkaloids; D014750:Vincristine; D014747:Vinblastine