title: [Treatment of diarrhea with difenoxin hydrochloride in children (author's transl)].
abstract: In an open clinical study symptomatic treatment was given to 93 children aged 16 days to 24 months who suffered from acute diarrhea. All the patients received antidiarrheal diet suited to their age. If indicated, the children were rehydrated with electrolyte and buffer solutions. In order to reduce the intestinal motility as well as the loss of water and electrolyte in the stool, but not to stop the stools, difenoxin hydrochloride (Lyspafen) in the commercial composition was prescribed. The dose was 1 drop/kg body weight/day administered in 3 single doses. The preparation was administered to the children for 4-6 days on the average. Regardless of the bacteriological findings in the stools, very good results were obtained in 59 patients (63.44%); sufficient results in 19 children (20.43%); and poor results in 15 children (16.13%). In the group with negative stool samples very good results were obtained in 74% of the patients. The therapeutic results were very good to sufficient in the majority of cases belonging to the group with facultative pathogenic germs and pathogenic coli in the stools. In 66.67% (4 cases) of the children infected by Salmonellae and Shigellae the treatment was insufficient. No undesirable adverse reactions were seen in the children treated. Summing-up of the results revealed that cure of or improvement in the diarrhea was obtained in 83.87% of the test population.
mesh_terms: D002675:Child, Preschool; D003968:Diarrhea, Infantile / Q000188:drug therapy* / Q000209:etiology / Q000382:microbiology; D004157:Diphenoxylate / Q000627:therapeutic use*; D004405:Dysentery, Bacillary / Q000188:drug therapy; D005243:Feces / Q000382:microbiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007540:Isonipecotic Acids / Q000627:therapeutic use*; D012480:Salmonella Infections
chemical_list: D007540:Isonipecotic Acids; D004157:Diphenoxylate
vernacular_title: Behandlung der Diarrhöe bei Kindern mit Difenoxin-hydrochlorid.