Immunosuppression in murine malaria. II. The primary response to bovine serum albumin.
The primary antibody response to alumadsorbed bovine serum albumin was depressed in CBA mice infected with Plasmodium yoelii yoelii. Responses initiated within approximately 3 weeks of this malaria infection were reduced in quantity, but not in avidity. Responses initated later were normal. A depressed primary response was also seen in infected compared to control splenectomized mice; this was accompanied by impaired  priming for a secondary response.
D000208:Acute Disease; D000534:Alum Compounds; D000818:Animals; D000917:Antibody Formation; D001666:Binding Sites, Antibody; D002417:Cattle; D005260:Female; D007156:Immunologic Memory; D007164:Immunosorbents; D007165:Immunosuppression Therapy; D008288:Malaria / Q000276:immunology*; D051379:Mice; D008808:Mice, Inbred CBA; D012710:Serum Albumin, Bovine / Q000276:immunology*; D013156:Splenectomy
D000534:Alum Compounds; D007164:Immunosorbents; D012710:Serum Albumin, Bovine