Investigations on the action of cefazedone and gentamicin, alone and combined, on renal enzyme excretion in rats.
Administration of (6R, 7 R)-7-(2-[3,5-dichloro-4-oxo-1(4 H)-pyridyl]-acetamido)-3-([(5-methyl-1,3,4-thiadiazol-2-yl)-thio]methyl)-8-oxo-5-thia-azabicyclo[4,2,0]oct-2-ene-2-carboxylic acid (cefazedone, Refosporen) in a dose of 1000 mg/kg led to a statistically significant rise of the alkaline phosphatase activity in rat urine. The excretion of leucinaminopeptidase activity was not significantly affected. The enzyme activity in the animals' urine was raised by the administration of 100 mg/kg of gentamicin. Combined administration of the two antibiotics in the doses mentioned did not lead to any additive action. The established increases in activity were in the same range as after the administration of only one of the antibiotics.
D000469:Alkaline Phosphatase / Q000652:urine*; D000818:Animals; D002511:Cephalosporins / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D005839:Gentamicins / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology; D007931:Leucyl Aminopeptidase / Q000652:urine*; D051381:Rats
D002511:Cephalosporins; D005839:Gentamicins; D000469:Alkaline Phosphatase; D007931:Leucyl Aminopeptidase