title: Studies on isoprenaline-induced myocardial lesions. 1. Quantitative evaluation by mercurascan uptake.
abstract: For the quantitative evaluation of myocardial damage induced by isoprenaline (ISO) a method based on the uptake of 203Hg-labelled Mercurascan (MSC) in the heart was used. The increase of myocardial uptake of MSC in ISO-treated rats over control values was very rapid and might be directly proportional to the number of damaged myocardial cells actually present in the heart. MSC-uptake method of myocardial damage evaluation was more sensitive and precise than other methods tested (macroscopic evaluation according to Rona, increase of heart weight). Different modifications of MSC-uptake test may be selected in relation to experimental conditions. MSC test is especially useful for evaluation of early myocardial lesions induced by small doses of ISO (0.01 mg/kg).
mesh_terms: D000818:Animals; D005452:Fluoresceins / Q000378:metabolism*; D006321:Heart / Q000187:drug effects*; D006331:Heart Diseases / Q000139:chemically induced; D007545:Isoproterenol / Q000009:adverse effects*; D008433:Mathematics; D008631:Mercury Radioisotopes; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D013997:Time Factors
chemical_list: D005452:Fluoresceins; D008631:Mercury Radioisotopes; D007545:Isoproterenol