title: [On the effect of the antidepressant viloxazin on EEG and optimization of the system driver-vehicle-road (author's transl)].
abstract: The effects of a single dose of 100 mg 2-[(o-ethoxyphenoxy)-methyl]-morpholine hydrochloride (viloxazin) on EEG and optimizing control behaviour of drivers were investigated under double-blind conditions in 5 male subjects with many years' driving experience. The study was carried out on a special test course using a car equipped with measuring devices. The following signals were recorded: EEG and EOG, driving speed, steering torque, steering angle and angle rate, longitudinal and lateral acceleration, and yaw rate. As evaluated by means of spectral analysis with a subsequent principal component analysis the EEG showed an increase of the power in alpha- and beta-frequencies indicating a drug induced decrease of EEG vigilance. In correspondence the optimization of the system driver-vehicle-road was reduced indicating an impairment of the driver's control behaviour.
mesh_terms: D000328:Adult; D001334:Automobile Driving; D004311:Double-Blind Method; D004569:Electroencephalography; D004585:Electrooculography; D006801:Humans; D008297:Male; D009025:Morpholines / Q000494:pharmacology*; D009048:Motor Skills / Q000187:drug effects*; D014745:Viloxazine / Q000494:pharmacology*
chemical_list: D009025:Morpholines; D014745:Viloxazine
vernacular_title: Zur Wirkung des Antidepressivums Viloxazin auf das hirnelektrische Verhalten und die Optimierung des Systems Fahrer-Fahrzeug-Strasse.