Prazosin combined with thiazide diuretic and beta-blocker in the treatment of hypertension.
In a study of 10 patients suffering from hypertension the results showed that combination treatment with prazosin, cyclopenthiazide and a beta-blocker produced a significant fall in blood pressure. Side-effects such as palpitations, headache, syncope and drowsiness which may occur with prazosin alone were obviated by combining prazosin with a beta-blocker.
D001794:Blood Pressure; D003518:Cyclopenthiazide / Q000008:administration & dosage* / Q000627:therapeutic use; D004232:Diuretics; D004359:Drug Therapy, Combination; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D010869:Pindolol / Q000008:administration & dosage* / Q000627:therapeutic use; D011224:Prazosin / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D011433:Propranolol / Q000008:administration & dosage* / Q000627:therapeutic use; D011674:Pulse; D011799:Quinazolines / Q000008:administration & dosage*; D049993:Sodium Chloride Symporter Inhibitors / Q000008:administration & dosage*
D004232:Diuretics; D011799:Quinazolines; D049993:Sodium Chloride Symporter Inhibitors; D011433:Propranolol; D010869:Pindolol; D003518:Cyclopenthiazide; D011224:Prazosin