title: Synthesis, pharmacologic and toxicologic study of carbonic and carbamic acid esters.
abstract: The results of the pharmacologic study of some synthesized derivatives of carbamic and carbonic acids show that the compounds are biologically active. They are less toxic than imipramine, and exert a marked excitation effect on the central nervous system. Some of the compounds (including PS-1, P-8-Y and PS-4) possess greater antidepressive action than imipramine.
mesh_terms: D000818:Animals; D002219:Carbamates / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D002254:Carbonates / Q000138:chemical synthesis*; D002255:Carbonic Acid / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D055598:Chemical Phenomena; D002621:Chemistry; D004952:Esters; D008297:Male; D051379:Mice; D051381:Rats; D012110:Reserpine / Q000037:antagonists & inhibitors
chemical_list: D002219:Carbamates; D002254:Carbonates; D004952:Esters; D002255:Carbonic Acid; D012110:Reserpine