title: [High-dosage glucocorticoid therapy in acute heart infarct and in cardiogenic shock].
abstract: 40 patients with cardiogenic shock in consequence of contractility insufficiency of the heart were treated with high doses of prednisolon for short time. In 10 cases a good result of the treatment was to be seen so that the lethality quota was smaller than that of a reference group of the same age. The pharmacodynamic effect is seen in an improvement of the micro-circulation by a peripheric vasodilatation. 10 patients with acute myocardial infarction got a therapy with glucocorticoid combined with a treatment with anti-coagulants during the first both weeks. In this connection modern experimental examinations of animals are discussed which showed that glucocorticoides improve the anoxy tolerance of the heart muscle cell.
mesh_terms: D000208:Acute Disease; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology; D011239:Prednisolone / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D012770:Shock, Cardiogenic / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D011239:Prednisolone
vernacular_title: Zur hochdosierten Glukokortikoidtherapie bei akutem Herzinfarkt und kardiogenem Schock.