Effect of nitrofurantoin on meiosis of the male mouse.
The effects of nitrofurantoin [N-(5-nitro-2-furfurylidine)-1-amino-hydantoin] on chromosomes of primary and secondary spermatocytes of mice were studied. No mutagenic activity was detectable after application of either 8 mg/kg or 40 mg/kg nitrofurantoin. An increase in the univalent rates and a decrease in the chiasma frequencies was observed in treated animals. The probable origins of these effects are discussed.
D000818:Animals; D008297:Male; D008540:Meiosis / Q000187:drug effects*; D051379:Mice; D009582:Nitrofurantoin / Q000494:pharmacology*; D013090:Spermatocytes
D009582:Nitrofurantoin