title: Effects of lasalocid and monensin in combination with roxarsone on lesion reduction and oocyst suppression in chicks infected with Eimeria tenella field isolates.
abstract: The anticoccidial activity of lasalocid, monensin, and roxarsone, alone and in combination, was evaluated against eleven Eimeria tenella recent field isolates. Lasalocid was used at 0.0075. 0.01, and 0.0125% activity drug in feed; monensin at 0.0099 and 0.0121%; and roxarsone at 0.005%. Further studies with lasalocid 0.0075%, monensin 0.0099% and roxarsone 0.005 and 0.0025% combinations were carried out against three E. tenella field isolates selected from the aforementioned strains. Lasalocid and monensin each exhibited a high degree of anticoccidial activity at all concentrations tested. Lasalocid and monensin fed in combination with roxarsone showed, in addition to high anticoccidial activity a further reduction in gross lesions and oocysts production, more pronounced at 0.005% level of roxarsone than at 0.0025%, compared to either medication alone or the roxarsone combinations. These positive effects were noted with all strains tested. The practical aspects of these findings are discussed.
mesh_terms: D000284:Administration, Oral; D000821:Animal Feed; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001152:Arsenicals / Q000008:administration & dosage*; D002645:Chickens; D003048:Coccidiosis / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D004338:Drug Combinations; D005243:Feces / Q000469:parasitology; D005260:Female; D005663:Furans / Q000008:administration & dosage*; D007832:Lasalocid / Q000008:administration & dosage* / Q000627:therapeutic use; D008297:Male; D008985:Monensin / Q000008:administration & dosage* / Q000627:therapeutic use; D011201:Poultry Diseases / Q000188:drug therapy* / Q000469:parasitology; D012406:Roxarsone / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D001152:Arsenicals; D004338:Drug Combinations; D005663:Furans; D008985:Monensin; D012406:Roxarsone; D007832:Lasalocid