The dose response of several benzimidazole anthelmintics against resistant strains of Haemonchus contortus and Trichostrongylus colubriformis selected with thiabendazole.
Dose response lines for eight benzimidazole anthelmintics and thiophanate were determined, using standardised strains of thiabendazole selected and resistant Haemonchus contortus and Trichostrongylus colubriformis. Against H contortus, thiophanate, thiabendazole, parbendazole and oxibendazole were inactive. Mebendazole was inactive at dose rates of 6.26 and 12.5 mg/kg, although significant activity occurred at 25 mg/kg. Fenbendazole, cambendazole, oxfendazole and albendazole demonstrated significant activity at dose rates equal to or greater than the recommended therapeutic level. Thiophanate was inactive against resistant T colubriformis. The remaining compounds only showed significant activity when used at dose rates in excess of the recommended therapeutic level. These results show that a side resistance exists among the benzimidazole anthelmintics and suggests that changes in dose response lines could be expected to occur if resistant strains are selected with benzimidazoles other than thiabendazole.
D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D001562:Benzimidazoles / Q000494:pharmacology*; D002159:Cambendazole / Q000494:pharmacology; D002219:Carbamates / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance; D005273:Fenbendazole / Q000494:pharmacology; D006189:Haemonchus / Q000187:drug effects* / Q000254:growth & development; D013827:Thiabendazole / Q000494:pharmacology*; D013875:Thiophanate / Q000494:pharmacology; D014251:Trichostrongyloidea / Q000187:drug effects* / Q000254:growth & development
D000871:Anthelmintics; D001562:Benzimidazoles; D002219:Carbamates; C011321:oxibendazole; D002159:Cambendazole; D013875:Thiophanate; D005273:Fenbendazole; D013827:Thiabendazole; C011030:oxfendazole