Interaction between aldosterone and renomedullary prostaglandins. Competitive action between aspirin and spironolactone.
Aldosterone injected i.m. decreased the release of renomedullary PGEs and the index (urinary Na/K ratio) in conscious normotensive intact and adrenalectomized rats. Coadministration of spironolactone increased the release of PGEs as well as the index (urinary Na/K ratio). The effect of spironolactone was partly inhibited by aspirin injected in a ratio 5:1 (aspirin:spironolactone), and effect which could be reversed by the infusion of a synthetic prostaglandin (PGA2) in a subhypotensive dose.
D000315:Adrenalectomy; D000450:Aldosterone / Q000494:pharmacology*; D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D008297:Male; D011188:Potassium / Q000652:urine; D011455:Prostaglandins A, Synthetic / Q000494:pharmacology*; D011458:Prostaglandins E / Q000378:metabolism*; D051381:Rats; D012964:Sodium / Q000652:urine; D013148:Spironolactone / Q000494:pharmacology*
D011455:Prostaglandins A, Synthetic; D011458:Prostaglandins E; D013148:Spironolactone; D000450:Aldosterone; D012964:Sodium; D001241:Aspirin; D011188:Potassium