Effect of metoclopramide on prolactin secretion in man.
Prolactin (PRL) secretion was studied after i.m. administration of Metoclopramide (alone or with a pretreatment with 5-Br-2alpha-ergo-cryptine) and after i.m. administration of Sulpiride. The results obtained evidenced a considerable hPRL increase after Metoclopramide administration, similar to that observed with Sulpiride, completely abolished by 5-Br-2alpha-ergocryptine. On the basis of these data it seems evident a strong and specific effect of Metoclopramide on hPRL secretion, probably more potent than Sulpiride.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001971:Bromocriptine / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology*; D008875:Middle Aged; D011388:Prolactin / Q000378:metabolism*; D013469:Sulpiride / Q000494:pharmacology
D001971:Bromocriptine; D013469:Sulpiride; D011388:Prolactin; D008787:Metoclopramide