Creatine during bleeding anemia of rabbits.
In bleeding induced anemia of rabbits an increase of creatine in the red cells occurred, which in some cases amounted to more than 5-times the normal concentration. In all but one case plasma creatine rose as well. Reticulocytosis, increased O2-consumption of the red cells and an increased level of erythropoietin indicated active erythropoiesis and a shift towards a younger cell population. Whether the rise of red cell creatine is solely due to a higher proportion of young cells remains an open question.
D000740:Anemia / Q000097:blood*; D000818:Animals; D003401:Creatine / Q000097:blood*; D004912:Erythrocytes / Q000378:metabolism; D006400:Hematocrit; D006470:Hemorrhage / Q000097:blood*; D051379:Mice; D010101:Oxygen Consumption; D011817:Rabbits; D012156:Reticulocytes / Q000378:metabolism
D003401:Creatine