The effect of a non-absorbable fat, sucrose polyester, on the metabolism of vitamin A by the rat.
Sucrose polyester (SPE) is a fat-like material that is not absorbed. The effect of this material on vitamin A metabolism was determined by measuring the amount of the vitamin that was stored in the liver of rats following the ingestion of a known amount of vitamin A. In one study, the vitamin A was administered as an oral dose in a vehicle consisting of various proportions of cottonseed oil and SPE. Each 1% replacement of cottonseed oil by SPE resulted in a 0.26% decrease in the amount of vitamin A found in the liver. In the second study, the vitamin A was incorporated into diets in which the fat component consisted of various proportions of cottonseed oil and SPE. When these diets were consumed for 1 week, each 1% replacement of cottonseed oil by SPE resulted in a 0.84% decrease in the storage of vitamin A by the liver. It is proposed that in the lumen of the intestine vitamin A distributes between the customary micellar phase and the unhydrolyzed oil phase of SPE. The vitamin A in this latter phase is eliminated in the feces.
D000042:Absorption; D000818:Animals; D003369:Cottonseed Oil; D004305:Dose-Response Relationship, Drug; D005227:Fatty Acids / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism*; D008297:Male; D011091:Polyesters / Q000032:analysis; D051381:Rats; D013395:Sucrose / Q000031:analogs & derivatives* / Q000494:pharmacology; D014801:Vitamin A / Q000008:administration & dosage / Q000378:metabolism*
D003369:Cottonseed Oil; D005227:Fatty Acids; D011091:Polyesters; D014801:Vitamin A; D013395:Sucrose