title: Rampant dental caries in the treatment of depression.
abstract: Dental Caries are an uncommon, but significant side effect of the tricyclic antidepressants and other anticholinergic psychoactive drugs. The authors trace the etiological aspects of this syndrome including the effects of depression and antidepressant medication on salivary properties. A typical clinical presentation of the syndrome is described and the side effect profiles of the various tricyclic antidepressants are compared. With this clinical background guidelines for the management of dry mouth are presented, emphasizing the importance of technical skill, safety and continuity of care.
mesh_terms: D000328:Adult; D000639:Amitriptyline / Q000009:adverse effects; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects*; D003731:Dental Caries / Q000139:chemically induced*; D003863:Depression / Q000188:drug therapy*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007099:Imipramine / Q000009:adverse effects; D010546:Perphenazine / Q000009:adverse effects; D010862:Pilocarpine / Q000627:therapeutic use; D014987:Xerostomia / Q000139:chemically induced / Q000188:drug therapy
chemical_list: D000929:Antidepressive Agents, Tricyclic; D004338:Drug Combinations; D010862:Pilocarpine; D000639:Amitriptyline; D010546:Perphenazine; D007099:Imipramine