Study of lung surfactant activity in guinea pigs after vagotomy.
Vagotomy in guinea-pigs reduces the pulmonary surfactant activity. Unilateral vagotomy brings about a similar reduction in the lung on the same side. The findings indicate that surfactant reduction may be an important causative factor in the initiation of pulmonary edema in vagotomised guinea-pigs. It is suggested that surfactant synthesis or release may be affected by alterations in the pulmonary blood flow or removal of the effect of neuro-secretory fibres, following vagotomy.
D000818:Animals; D005260:Female; D006168:Guinea Pigs; D008168:Lung / Q000378:metabolism; D008297:Male; D011654:Pulmonary Edema / Q000209:etiology*; D011663:Pulmonary Surfactants / Q000378:metabolism*; D014628:Vagotomy / Q000009:adverse effects*
D011663:Pulmonary Surfactants