Interaction between a synthetic polypeptide, TIGAL, and Fc receptors on non-bursa-derived chicken lymphoid cells.
Autoradiographic studies have shown that radioiodinated TIGAL binds in vitro to a small but varying fraction of lymphoid cells from bursectomized, agammaglobulinemic chickens, whereas no binding of radioiodinated TGAL or a variety of other radioiodinated antigens can be observed. The binding of [125I]TIGAL is inhibited by antigen-antibody complexes. Radioiodinated antigen-antibody complexes are bound to a similar proportion of the lymphoid cells from bursectomized chickens, and this binding is inhibited by preincubation of the cells with unlabeled TIGAL but not with TGAL. These results indicate a cross-reaction at the level of Fc receptors between determinants on TIGAL and on IgG.
D000418:Albumins / Q000276:immunology; D000818:Animals; D000936:Antigen-Antibody Complex; D001345:Autoradiography; D001666:Binding Sites, Antibody; D002060:Bursa of Fabricius / Q000601:surgery*; D002645:Chickens; D005293:Ferritins / Q000276:immunology; D007141:Immunoglobulin Fc Fragments; D007457:Iodine Radioisotopes; D007962:Leukocytes / Q000276:immunology; D010455:Peptides / Q000276:immunology*; D051381:Rats
D000418:Albumins; D000936:Antigen-Antibody Complex; D007141:Immunoglobulin Fc Fragments; D007457:Iodine Radioisotopes; D010455:Peptides; D005293:Ferritins