[Role of antigens and adjuvant substances in the histological response in experimental granulomas (immunogenic granuloma)].
The injection in rabbits of vaccinal antigens combined with immunity adjuvants (in particular calcium phosphate) causes a local lesion in which it is possible to recognize histologically, after a transitory afflux of polymorphonuclear leukocytes, a central area of adjuvant deposit, a middle area of histiocytes and monocytes, and a peripheral immunogenic area of lymphocytes and plasmocytes. These two cellular zones are rich in highly fluorescent cells in the presence of an antiglobulin serum with an embedding technique which respects to the upmost the structures and immunoreactivity of the cells. These histological features are not completely observed on the separate injection of antigen or adjuvant. They must be interpreted, after a fleeting non-specific reaction, while taking into account the still poorly understood method of action of the inorganic adjuvant and spread of the antigen in the organism.
D000276:Adjuvants, Immunologic; D000818:Animals; D000941:Antigens; D005453:Fluorescence; D006099:Granuloma / Q000276:immunology* / Q000473:pathology; D006967:Hypersensitivity / Q000276:immunology*; D011817:Rabbits; D014612:Vaccines
D000276:Adjuvants, Immunologic; D000941:Antigens; D014612:Vaccines
Rôle des antigènes et des substances adjuvantes dans la réponse histologique au cours de granulomes expérimentaux ("granulome immunogène").