title: A new easily accessible steric parameter for structure-activity relationships.
abstract: A simple steric parameter Sb is formulated on the basis of substituent branching. This parameter can be calculated for every conceivable substituent and gives an estimate of steric effects which is sufficient for most purposes in practical drug design. Sb may also be applied to quantitative structure-activity relationships.
mesh_terms: D008956:Models, Chemical; D008968:Molecular Conformation; D013329:Structure-Activity Relationship