[No increase in chemotherapeutic effectiveness of cyclophosphamide (CPA) in rat leukemia L 5222 by 5-ethyl-2'-deoxyuridine (EDU) (author's transl)].
Monotherapy of early rat leukemia L 5222 with 5 X 100 mg/kg EDU over 48 h yielded no increase in lifespan as compared to untreated controls. Combination therapy of advanced L 5222 with EDU and CPA in four different schedules results in no increase in life-span as compared to treatment with CPA only. DNA histogrms of preterminal L 5222 revealed no synchronizing effect of EDU.
D000818:Animals; D003520:Cyclophosphamide / Q000627:therapeutic use*; D004273:DNA, Neoplasm / Q000032:analysis; D003857:Deoxyuridine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004347:Drug Interactions; D007942:Leukemia, Experimental / Q000188:drug therapy*; D051381:Rats
D004273:DNA, Neoplasm; D003520:Cyclophosphamide; D003857:Deoxyuridine
Keine Steigerung der chemotherapeutischen Wirkung von Cyclophosphamid durch 5-Athyl-2'-deoxyuridin an der Rattenleukämie L 5222.