Pancuronium requirements. With special reference to serum protein pattern.
Requirements of pancruonium were evaluated in 50 adult patients undergoing abdominal surgery in halothane anaesthesia. A significant negative correlation was found between gamma-globulin and the apnoeic dose of pancuronium (r = --0.335, P less than 0.02), on the one hand, and the apnoeic period after it (r = --0.311, P less than 0.05), on the other hand. beta-Globulin displayed a significant positive correlation with the apnoeic period after pancuronium (r = 0.344, P less than 0.02). The heavier patients necessitated less drug/kg bw. to obtain apnoea than the leaner ones did. Finally, the females showed a higher sensitivity to pancuronium in comparison to the males.
D000328:Adult; D000368:Aged; D000375:Aging; D000758:Anesthesia; D001798:Blood Proteins / Q000378:metabolism; D001835:Body Weight; D005260:Female; D006221:Halothane; D006801:Humans; D008297:Male; D008875:Middle Aged; D009126:Muscle Relaxation / Q000187:drug effects; D010197:Pancuronium / Q000008:administration & dosage* / Q000097:blood; D011485:Protein Binding; D013997:Time Factors
D001798:Blood Proteins; D010197:Pancuronium; D006221:Halothane