Heterophile antibodies. Part II. An evaluation of the effect of autologous blood group substances on the natural formation of agglutinating antibodies to sheep red blood cells.
This study shows that some substances in human secretions can inhibit the agglutination of sheep red blood cells by human antibodies. When present in adequate concentrations, they can also inhibit the reaction of the donor's own sheep red blood cell antibody activity in vito. The subjects in whom this phenomenon was found almost always had low agglutinating antibody titers to sheep red blood cells. The inhibiting activity of saliva for sheep red blood cell antibodies was influenced by the ABH secretor status. Substances reacting against sheep red blood cell antibodies occur in the secretions in considerably smaller quantities than ABH substances.
D000017:ABO Blood-Group System; D000373:Agglutinins; D000818:Animals; D000910:Antibodies, Heterophile; D000917:Antibody Formation; D006801:Humans; D007518:Isoantibodies; D012463:Saliva / Q000276:immunology; D012756:Sheep / Q000276:immunology*; D014182:Transplantation, Autologous
D000017:ABO Blood-Group System; D000373:Agglutinins; D000910:Antibodies, Heterophile; D007518:Isoantibodies