Effect of acid on the motility of the oesophagus of the pig with experimentally induced oesophagitis.
The mucous membrane of the oesophagus of 6 pigs was experimentally damaged with hydrochloric acid to create changes similar to reflux oesophagitis. The passage of contrast medium through the oesophagus of the pigs was observed by using spot radiography and pressure measurements. Acid contrast medium caused spasms and nonperistaltic pressure waves during the act of swallowing. Conventional contrast medium traversed the oesophagus normally and the swallowing complex was normal. On the basis of this experimental model it is concluded that the acidity of a bolus is of fundamental importance in the aetiology of spasms in oesophagitis.
D000818:Animals; D001466:Barium Sulfate; D004942:Esophagitis, Peptic / Q000503:physiopathology*; D004947:Esophagus / Q000187:drug effects* / Q000503:physiopathology; D006851:Hydrochloric Acid / Q000494:pharmacology*; D009092:Mucous Membrane / Q000187:drug effects; D010528:Peristalsis / Q000187:drug effects; D013552:Swine
D001466:Barium Sulfate; D006851:Hydrochloric Acid