title: Physiological, biochemical, and morphological characteristics of myocardial anoxia: the use of a semi-perfusion canine preparation.
abstract: Regional myocardial anoxia was produced in dogs by perfusion of the left circumflex artery (LCA) with deoxygenated blood. Isolated sarcoplasmic reticulum fragments (cardiac relaxing system) showed decreased Ca2+ binding and uptake. The ability of isolated mitochondria to utilise long-chain fatty acids was markedly reduced. This model has revealed inherent biochemical differences between ischaemia and anoxia.
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D003327:Coronary Disease / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D004285:Dogs; D000860:Hypoxia / Q000378:metabolism* / Q000503:physiopathology; D066298:In Vitro Techniques; D008929:Mitochondria, Heart / Q000378:metabolism; D009200:Myocardial Contraction; D009206:Myocardium / Q000473:pathology; D010085:Oxidative Phosphorylation; D012519:Sarcoplasmic Reticulum / Q000378:metabolism
chemical_list: D002118:Calcium