[Effect of sodium selenite, alpha-tocopherol and their combinations on the indices of the functional state of the heart regulation adren- and cholinergic systems in experimental myocardial infarct].
A course-wise administration of sodium selenate (30 gamma/kg), alpha-tocopherol (50 mg/kg) and of their combination in the same doses brings down the catecholamines content in the heart and suprarenals in the acute period of developing myocardial infarction (2nd day) with its subsequent normalization on the 14th day. Under the effect of these drugs the proportion of acetylcholine-like substances in the heart with experimental infarction rises at the expense of an accruing free (unbound with protein) fraction. The cholinesterase activity then gets intensified in the acute period and becomes normal by the 14th day.
D000109:Acetylcholine / Q000378:metabolism; D000208:Acute Disease; D000818:Animals; D000975:Antioxidants; D004338:Drug Combinations; D004341:Drug Evaluation; D004562:Electrocardiography; D004837:Epinephrine / Q000378:metabolism; D006329:Heart Conduction System / Q000187:drug effects*; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000378:metabolism; D009336:Necrosis; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects; D011950:Receptors, Cholinergic / Q000187:drug effects; D012643:Selenium / Q000627:therapeutic use*; D013997:Time Factors; D014810:Vitamin E / Q000627:therapeutic use*
D000975:Antioxidants; D004338:Drug Combinations; D011941:Receptors, Adrenergic; D011950:Receptors, Cholinergic; D014810:Vitamin E; D012643:Selenium; D000109:Acetylcholine; D009638:Norepinephrine; D004837:Epinephrine
Vliianie selenita natriia, al'fa-tokoferola i ikh kombinatsii na nekotorye pokazateli funktsional'nogo sostoianiia adren- i kholinergicheskoĭ sistemy reguliatsii serdtsa pri éksperimental'nom infarkte miokarda.