Mitochondrial pathology in the liver in a patient with the Dubin-Johnson syndrome.
Electron microscopy study of a liver biopsy from a patient with the Dubin-Johnson syndrome revealed evidence of severe mitochondrial damage. The changes included membranous whorls, isolated intramitochondrial membranes, myelin figures and large cytoplasmic vacuoles, presumably representing degenerated micochondria. Mitochondrial damage should be looked for in future electron microscopy studies in patients with the Dubin-Johnson syndrome.
D005260:Female; D006801:Humans; D007566:Jaundice, Chronic Idiopathic / Q000473:pathology*; D008099:Liver / Q000648:ultrastructure; D008875:Middle Aged; D008930:Mitochondria, Liver / Q000473:pathology*