[Antimicrobial activity of the broad spectrum antimycotic isoconazole nitrate in humans (author's transl)].
A comparative study (occlusion test according to Marples and Kligman) was conducted in 100 test subjects with several formulations of isoconazole nitrate. The following results were obtained: 1. There are no differences in efficacy between the free base, isoconazole, and the nitrate. 2. Increasing the active substance concentration of isoconazole nitrate above 1% produced a noticeable increase in its effect so that 2% and 4% preparations are appropriate for particular uses. 3. 1% isoconazole nitrate (Travogen cream, Gyno-Travogen cream) is more effective than a commercial cream containing 1% clotrimazole. 4. The addition of a corticosteroid (diflucortolone-21-valerate 0.1%, Travocort cream) does not influence the action of isoconazole nitrate.
D003022:Clotrimazole / Q000494:pharmacology; D003881:Dermatomycoses / Q000188:drug therapy; D004060:Diflucortolone / Q000494:pharmacology; D004338:Drug Combinations; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology*; D008825:Miconazole / Q000031:analogs & derivatives / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009824:Ointments; D012867:Skin / Q000382:microbiology*
D004338:Drug Combinations; D007093:Imidazoles; D009824:Ointments; D008825:Miconazole; D003022:Clotrimazole; D004060:Diflucortolone
Antimikrobielle Wirksamkeit des Breitspektrum-Antimykotikums Isoconazolnitrat im Humanversuch.