A further contribution to the choice of the dose for L-tryptophan load test.
The analysis of the results of a study on the urinary excretion of metabolites "via kynurenine" after the ingestion in man of different amounts of tryptophan is reported. Of the three doses of L-tryptophan administered to the subjects, that is 2 g pro capite, 50 mg/Kg and 75 mg/Kg body weight, it is preferable to choose that of 50 mg/Kg b.w. as a load test. Such a dose assures an excretion of the more important metabolites without significant variations between men and women and without producing overloading effects.
D000618:Aminohippuric Acids / Q000652:urine; D001835:Body Weight; D005260:Female; D006801:Humans; D007736:Kynurenic Acid / Q000652:urine; D007737:Kynurenine / Q000378:metabolism* / Q000652:urine; D008297:Male; D012737:Sex Factors; D014364:Tryptophan / Q000008:administration & dosage* / Q000378:metabolism; D014977:Xanthurenates / Q000652:urine; D062367:ortho-Aminobenzoates / Q000652:urine
D000618:Aminohippuric Acids; D014977:Xanthurenates; D062367:ortho-Aminobenzoates; D007737:Kynurenine; D014364:Tryptophan; D007736:Kynurenic Acid