[Insulin-poietic effect of pentagastrin after beta-adrenergic block in the anesthesized dog].
Infusion of pentagastrin (5-G) into the femoral vein of anaesthesized dogs, in doses of 0.20 microgram/kg/min for 30 minutes, causes a prompt and significant increase in plasma IRI. The insulin-secretory effect of the peptide was not affected by 0.5 mg/kg i.v. of propranolol (a beta-adrenergic blocking agent) or by 1.3 mg/kg i.v. of practolol (a selective beta1-adrenergic blocking agent). These results show that the action of 5-G on the pancreatic beta-cells could be not related to the beta-adrenergic system.
D000758:Anesthesia; D000818:Animals; D000941:Antigens; D005260:Female; D007275:Injections, Intravenous; D007328:Insulin / Q000096:biosynthesis* / Q000097:blood; D008297:Male; D010179:Pancreas / Q000187:drug effects; D010418:Pentagastrin / Q000008:administration & dosage / Q000494:pharmacology*; D011217:Practolol / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology*
D000941:Antigens; D007328:Insulin; D011433:Propranolol; D010418:Pentagastrin; D011217:Practolol
Effetto insulino-poietico della pentagastrina dopo blocco beta-adrenergico nel cane anestetizzato.