Effect of thiocyanate on mammary gland growth in rats.
In growing rats from 3 weeks to 3 months old, 0.1% potassium thiocyanate (KSCN) decreased the plasma protein-bound iodine level by 47% and the total DNA in the mammary gland by 11%, but had no effect on the total RNA. Administration of thiocyanate in the form of 0.1, 0.3 and 0.5% KSCN during pregnancy and 14 d of lactation lowered the protein-bound iodine level by 48-66%, the total DNA by 11-47% and the total RNA by 14-63%, depending on the KSCN dosage. The 14-d-old litters of rats receiving thiocyanate weighed 4-41% less than those in the control group.
D000818:Animals; D001798:Blood Proteins; D004247:DNA / Q000096:biosynthesis; D005260:Female; D007455:Iodine / Q000097:blood; D007774:Lactation; D008321:Mammary Glands, Animal / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D011247:Pregnancy; D011485:Protein Binding; D051381:Rats / Q000254:growth & development* / Q000378:metabolism; D013861:Thiocyanates / Q000494:pharmacology*
D001798:Blood Proteins; D013861:Thiocyanates; D004247:DNA; D007455:Iodine