title: [Comparison of the cardiac effects of triamterene and its phase II metabolite p-hydroxytriamterene sulphuric acid ester (author's transl].
abstract: The positive inotropic action of triamterene (TA) on isolated, electrically stimulated left atria was compared with that of its phase II metabolite, p-hydroxytriamterene sulphuric acid ester (OH-TA-ester). It was found that the metabolite also possesses a positive inotropic action, its potency, however, is about 10 times lower than that of triamterene.
mesh_terms: D000818:Animals; D006168:Guinea Pigs; D006900:Hydroxylation; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D013463:Sulfuric Acid Esters / Q000378:metabolism / Q000494:pharmacology; D014223:Triamterene / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D013463:Sulfuric Acid Esters; D014223:Triamterene
vernacular_title: Vergleich der kardialen Wirkung von Triamteren und dessen Phase-II-Metaboliten p-Hydroxytriamteren-schwefelsäureester.