The effects of some hydrophobic gases on the pulmonary surfactant system.
1. Decompression from exposures to raised ambient pressure of sulphur hexafluoride, carbon tetrafluoride, hexafluoro-ethane and nitrous oxide results in the formation of dense foam and pulmonary oedema. 2. The degree of pulmonary oedema produced is dependent on the exposure pressure, although the exposure time required is short in comparison to tissue saturation times. 3. The effect is not prevented by atropine, ephedrine or hydrocortisone. 4. The effect is also produced in vitro by saturated solutions of halothane, chloroform and ether. 5. It is suggested that the mechanism of action is physical with physico-chemical factor involved being a differential partition of these gases within the surfactant: membrane complex.
D000818:Animals; D001274:Atmospheric Pressure; D001285:Atropine / Q000494:pharmacology; D004809:Ephedrine / Q000494:pharmacology; D005459:Fluorides / Q000494:pharmacology; D005740:Gases / Q000494:pharmacology*; D006845:Hydrocarbons, Fluorinated / Q000494:pharmacology; D006854:Hydrocortisone / Q000494:pharmacology; D008297:Male; D051379:Mice; D009584:Nitrogen / Q000494:pharmacology; D009609:Nitrous Oxide / Q000494:pharmacology; D011654:Pulmonary Edema / Q000503:physiopathology; D011663:Pulmonary Surfactants / Q000502:physiology*; D013455:Sulfur / Q000494:pharmacology; D013997:Time Factors
D005740:Gases; D006845:Hydrocarbons, Fluorinated; D011663:Pulmonary Surfactants; D013455:Sulfur; D001285:Atropine; D004809:Ephedrine; D009609:Nitrous Oxide; D009584:Nitrogen; D005459:Fluorides; D006854:Hydrocortisone