[Pancreatic juice and stress ulcers of the rat (author's transl)].
In 55 rats the role of pancreatic juice for the development of stress ulcers was stuided. After ligation of the common bile duct the stress ulcer incidence was significantly decreased. An additional pancreaticogastrostomy was followed by an even lower ulcer frequency. After pancreaticojejunostomy a higher ulcer incidence was found as after bile duct ligation alone. The role of a duodenogastric reflux for development of stress ulcers is discussed. The ulcerogenic property of bile acids and of the combination of bile and pancreatic juice, caused by lysolecithin, is demonstrated. Pancreatic juice doesn't work as an ulcerogenic substance, but possibly has a protective function by uffering the hydrochloric acid.
D000818:Animals; D001647:Bile Acids and Salts; D008297:Male; D010189:Pancreatic Juice; D010437:Peptic Ulcer / Q000209:etiology*; D051381:Rats; D013312:Stress, Physiological
D001647:Bile Acids and Salts
Pankreassaft und Stressulcus der Ratte.