[Induction of fatty acid oxidation in peroxisomes of rat liver by magnesium-4 chlorophenoxyisobutyrate (Mg-CPIB)].
Magnesium-4-chlorophenoxyisobutyrate (Mg-CPIB) and ethyl-CPIB were administered to adult male rats. After one and two weeks, respectively, the peroxysomal fraction from the livers was isolated and activities of fatty acid beta-oxidation and catalase were measured. With both drugs, catalase activity was only slightly induced (50%), whereas a great increase of fatty acid oxidizing enzymes was observed. After both time intervals the inducing effect of the magnesium salt of CPIB was significantly higher than that of the ethyl ester. The bearing of the induction of peroxysomal fatty acid oxidation on the hypolipidemic effect of CPIB is discussed.
D000818:Animals; D002374:Catalase / Q000378:metabolism; D002994:Clofibrate / Q000031:analogs & derivatives*; D002995:Clofibric Acid / Q000494:pharmacology*; D005227:Fatty Acids / Q000378:metabolism*; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism* / Q000648:ultrastructure; D008297:Male; D008830:Microbodies / Q000187:drug effects / Q000378:metabolism*; D009940:Organoids / Q000378:metabolism*; D010084:Oxidation-Reduction; D051381:Rats
D005227:Fatty Acids; D002995:Clofibric Acid; D002374:Catalase; D002994:Clofibrate
Induktion der Fettsäureoxidation in Peroxysomen der Rattenleber durch Magnesium-4-chlorphenoxyisobutyrat.