[Methylcholanthrene sensitization in skin tumor induction].
Injection of 2 mg of methylcholanthrene renders a sensitizing effect on separate tissues and enhances the development of skin papillomas and cancer in skin application of methylcholanthrene. To the time of papillomas appearance sensitized animals showed immunosuppression being more significant than in nonsensitized mice. Animals with cancerous tumors, both sensitized and non-sensitized, showed paralysis of immunological mechanisms of the organism protection.
D000284:Administration, Oral; D000818:Animals; D002277:Carcinoma / Q000139:chemically induced / Q000276:immunology; D007114:Immunization; D008297:Male; D008748:Methylcholanthrene / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000276:immunology; D010212:Papilloma / Q000139:chemically induced / Q000276:immunology; D012878:Skin Neoplasms / Q000139:chemically induced / Q000276:immunology*; D013997:Time Factors
D008748:Methylcholanthrene
Sensibilizatsiia metilkholantrenom pri induktsii opukholeĭ kozhi.