A re-evaluation of antibiotic sterilisation of heart valve allografts.
Six different mixtures of antibiotics used for treating heart valve allografts at the National Heart Hospital have been compared and the formulation of the medium in current use is described. The abilities of antibiotic-resistant bacteria, and of fungi with low sensitivities to antifungal agents, to survive treatment are also described. These abilities emphasise the need for routine microbiological screening of every valve.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004338:Drug Combinations; D005069:Evaluation Studies as Topic; D006351:Heart Valves / Q000382:microbiology / Q000637:transplantation*; D006801:Humans; D013242:Sterilization / Q000379:methods*; D014184:Transplantation, Homologous
D000900:Anti-Bacterial Agents; D004338:Drug Combinations