[Electron microscopic study of the localization of adenylate cyclase in the small intestinal epithelial cells of rabbits with NAG-infections].
As found, in NAG-infection primary intensification of adenylate cyclase activity occurred at the apical plasmalemma of the villar cells; then the process spread to the lateral and further to the basal plasmalemma of the enterocytes. At more advanced stages of NAG-infection an increased adenylate cyclase activity was observed in the crypt cells. Thus, with increased duration of the toxin action there was a gradual rise of the enzyme activity, and the epithelial cells of the small intestine in the area of local affection become involved in the pathological process.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn; D002462:Cell Membrane / Q000201:enzymology; D004848:Epithelium / Q000201:enzymology; D006651:Histocytochemistry; D007413:Intestinal Mucosa / Q000201:enzymology*; D008854:Microscopy, Electron; D011817:Rabbits; D014735:Vibrio Infections / Q000201:enzymology*
D000262:Adenylyl Cyclases
Elektronno-mikroskopicheskoe izuchenie lokalizatsii adenilattsiklazy vépitelial'nykh kletkakh tonkoĭ kishki krolikov pri NAG-infektsii.