Carcinogenic effect of a quanidine pesticide administered with sodium nitrite on adult mice and on the offspring after prenatal exposure.
Adult Swiss mice were treated intragastrically during the last week of pregnancy with the fungicide dodecylquanidine acetate (dodine, DGA) together with 0.05% sodium nitrite. The incidence of malignant lymphomas, lung adenomas and hepatomas was 30--70% in females. The first tumors appeared 4 months after delivery in the FO generation and at 6--7 months in the F1 generation. Among the untreated control mice the frequency of spontaneous tumors was 6%, and lymphomas developed, if at all, only after 10 months. The oncogenic activity of DGA with sodium nitrite in the offspring was dependent on the dose of DGA.A and C type RNA virus particles were demonstrated in lymphomas by electronmicroscopy. DGA alone had no effect on the cancer incidence.
D000818:Animals; D002273:Carcinogens; D004357:Drug Synergism; D005260:Female; D005659:Fungicides, Industrial / Q000008:administration & dosage / Q000633:toxicity*; D006146:Guanidines / Q000008:administration & dosage / Q000633:toxicity*; D007181:Inclusion Bodies, Viral; D008228:Lymphoma, Non-Hodgkin / Q000139:chemically induced; D008297:Male; D008431:Maternal-Fetal Exchange; D051379:Mice; D009573:Nitrites / Q000633:toxicity*; D011247:Pregnancy; D012513:Sarcoma, Experimental / Q000139:chemically induced* / Q000648:ultrastructure; D012737:Sex Factors; D012977:Sodium Nitrite / Q000008:administration & dosage / Q000633:toxicity*
D002273:Carcinogens; D005659:Fungicides, Industrial; D006146:Guanidines; D009573:Nitrites; C006921:dodine; D012977:Sodium Nitrite