Comparative pharmacokinetics and relative bioavailability for different preparations of nitrofurantoin.
In a single-dose study three different dosage forms of nitrofurantoin tablets are compared in order to attain a longer duration of efficacy by means of sustained-release dosage forms. In particular, bioavailability and the rate constants are estimated and show for one dosage form significant advantages. The measured serum and urine concentration levels are evaluated with a two-compartment model of first order which assumed the sustained release of the drug in an exponential manner.
D000328:Adult; D001682:Biological Availability; D003692:Delayed-Action Preparations; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008954:Models, Biological; D009582:Nitrofurantoin / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*
D003692:Delayed-Action Preparations; D009582:Nitrofurantoin