Identification of dense deposit disease: a report for the International Study of Kidney Diseases in Children.
The fluorescent dye thioflavin T stains intensely the deposits in dense deposit disease and can be used for identification purposes. Comparison of thioflavin T staining with electron microscopy was carried out in 25 patients and showed excellent congruity. Thioflavin T is much easier to use, but is less specific than electron microscopy. Cases of light chain disease and of some gammopathies can be a source of confusion. In nearly all other instances, the pattern of staining helps to differentiate dense deposits from other types of deposits and from amyloid.
D001485:Basement Membrane / Q000473:pathology; D002648:Child; D005456:Fluorescent Dyes; D006801:Humans; D007668:Kidney / Q000473:pathology* / Q000648:ultrastructure; D007674:Kidney Diseases / Q000175:diagnosis / Q000473:pathology*; D007678:Kidney Glomerulus / Q000473:pathology
D005456:Fluorescent Dyes