title: [HLA markers and periodic disease [familial Mediterranean fever (F.M.F.)] (author's transl)].
abstract: Thirty-one unrelated patients, 15-52 years old, were typed by microlymphocytotoxicity for 27 alleles of the HLA system. In addition, 12 families including 1 or more patient were also analysed. This criteria for diagnosis were those of Sohar et all. (Am. Intern. Med., 1967, 43, 227-253). All patients were of Israelite-Sephardin origin except two (Armenian and French); they were from North-Africa (Tunisia, Morocco and Algeria) and Israël. The results were compared to the antigen frequencies of 3 reference normal populations. The frequencies of the studied alleles do not differ from those of controls, except for HL-A28 and B14 slightly increased when compared to the normal frequencies. The study of 7 families with at least two sibs suffering from FMF shows a random distribution of the genotypes : 2 HLA identical, 6 different and 10 haploidentical diseased sibs. This distribution differs significantly (p less than 0.01) from that expected in the case of a recessive inheritance. These data do not support the hypothesis of a linkage between genes controlling FMF and HLA genes.
mesh_terms: D000293:Adolescent; D000328:Adult; D000352:Africa, Northern / Q000208:ethnology; D003601:Cytotoxicity Tests, Immunologic; D010505:Familial Mediterranean Fever / Q000235:genetics / Q000276:immunology*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D007557:Israel / Q000208:ethnology; D007585:Jews; D008297:Male; D008875:Middle Aged; D010375:Pedigree
chemical_list: D006680:HLA Antigens
vernacular_title: Marqueurs HLA chez les sujets atteints de maladie périodique (fièvre familiale méditerranéenne).