The adjuvant effect of tuberculin in experimental sensitization to merthiolate.
When guinea pigs were sensitized to tuberculin by exposure to complete Freund's adjuvant the size of the intradermal PPD test was positively correlated to the body weight of the animal. Old Tuberculin showed stimulating effect in a subsequent sensitization to merthiolate (thimerosal). The high frequency of delayed cutaneous allergy to merthiolate in Swedish population is probably explained by sensitization through intradermal testing with tuberculin containing merthiolate as a preservative.
D000818:Animals; D003877:Dermatitis, Contact / Q000209:etiology; D005035:Ethylmercury Compounds / Q000276:immunology*; D005620:Freund's Adjuvant; D006168:Guinea Pigs; D007114:Immunization; D007271:Injections, Intradermal; D012882:Skin Tests; D013849:Thimerosal / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*; D014373:Tuberculin / Q000008:administration & dosage / Q000276:immunology*
D005035:Ethylmercury Compounds; D014373:Tuberculin; D013849:Thimerosal; D005620:Freund's Adjuvant