Studies on anticoccidial agents. 12. Synthesis and anticoccidial activity of methyl-2(6)-nitro- and -3(5)-nitropyridinecarboxamides.
A number of methyl-2- and 3-nitropyridinecarboxamides have been synthesized. It has been established that the presence of at least one hydrogen atom, adjacent to the NO2 function, is important for anticoccidial activity and introduction of a methyl group to the adjacent position of the CONH2 function sometimes confers enhanced activity. Among the compounds herein, 5- and 6-methyl-2-nitropyridine-4-carboxamides possess optimal anticoccidial activity, being as potent as the parent compound.
D003049:Coccidiostats / Q000138:chemical synthesis*; D004539:Eimeria / Q000187:drug effects; D007539:Isonicotinic Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D009539:Nicotinic Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D010848:Picolinic Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D003049:Coccidiostats; D007539:Isonicotinic Acids; D009539:Nicotinic Acids; D010848:Picolinic Acids