[Biochemical and pharmacological properties of new 2-substituted aziridines. Contribution to experimental tumor research].
A new class of compounds, the 2-cyanaziridines, has immune-modulating properties. This immune-modulation was proved by the influence on the delayed type hypersensitivity reaction, the increase of the lymphocyte transformation by T-cell-specific mitogens ConA and PHA, the increase of phagocytosis of macrophages, the increase of resistance against bacterial, fungal and virus infections and by the influence on various transplantation tumors in mice and rats.
D000818:Animals; D000970:Antineoplastic Agents; D001388:Aziridines / Q000494:pharmacology*; D001389:Azirines / Q000494:pharmacology*; D002177:Candidiasis / Q000517:prevention & control; D003520:Cyclophosphamide / Q000627:therapeutic use; D006968:Hypersensitivity, Delayed / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D009368:Neoplasm Transplantation; D010587:Phagocytosis / Q000187:drug effects
D000970:Antineoplastic Agents; D001388:Aziridines; D001389:Azirines; D003520:Cyclophosphamide
Biochemische und pharmakologische Eigenschaften neuer 2-substituierter Aziridine. Beiträge zur experimentellen Krebsforschung.