[Neurologic adverse manifestations and complications of ambulatory therapy with psychotropic drugs in the late stages].
Neurological side-effects and complications were studied in 100 patients having undergone long-term (3--14 years) out-patient treatment. In 14 cases there were slight side-effects. In patients of old age, after 6 year lithium treatment there were extrapyramidal signs, disturbances of memory and disorders of orientation in place. In 1 case following 2 year treatment with small doses of neuroleptical drugs there was an oral dyskinesia, after which an overdosage with antidepressive drugs and tranquillizers led to an akineticohypotonic syndrome. The side-effects and complications had a reversible character. Recommendations for therapy of such complications are given.
D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000009:adverse effects*; D001341:Autonomic Nervous System; D001480:Basal Ganglia Diseases / Q000139:chemically induced; D003072:Cognition Disorders / Q000139:chemically induced; D004409:Dyskinesia, Drug-Induced; D005260:Female; D006801:Humans; D008094:Lithium / Q000009:adverse effects* / Q000037:antagonists & inhibitors; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced / Q000188:drug therapy; D008875:Middle Aged; D009055:Mouth; D009422:Nervous System Diseases / Q000139:chemically induced; D009949:Orientation; D014149:Tranquilizing Agents / Q000009:adverse effects*; D014202:Tremor / Q000139:chemically induced; D005680:gamma-Aminobutyric Acid / Q000627:therapeutic use
D000928:Antidepressive Agents; D014149:Tranquilizing Agents; D005680:gamma-Aminobutyric Acid; D008094:Lithium
Nevrologicheskie pobochnye iavleniia i oslozhneniia na pozdnikh étapakh dlitel'noĭ ambulatornoĭ terapii psikhotropnymi preparatami.