Scopolamine does not affect footshock sensitivity in the rat.
To test the generality of the finding of Feigley, et al. [8] that scopolamine increases sensitivity/reactivity to footshock, rats were tested under either scopolamine or saline conditions for sensitivity to footshock in an automated version of the flinch-jump paradigm. There was no significant trend toward increased sensitivity following scopolamine injection at any of the response magnitudes assessed. Since the previous study included an operant response in the measure of sensitivity, it was suggested that apparent effects of scopolamine on reactivity to footshock are dependent on the inclusion of an operant response in the measure of reactivity, and are not due to changes in sensory thresholds.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004597:Electroshock; D004924:Escape Reaction / Q000187:drug effects; D008297:Male; D009619:Nociceptors / Q000187:drug effects*; D051381:Rats; D012601:Scopolamine / Q000494:pharmacology*
D012601:Scopolamine