Carbenicillin nephrotoxicity.
A patient with biopsy-proven interstitial nephritis associated with nafcillin and dicloxacillin therapy developed fever, hematuria, pyuria, and renal insufficiency after the administration of carbenicilin five months later. Cephalosporin therapy was given to this patient without signs of renal toxicity. This is the first reported case of probable carbenicillin-induced interstitial nephritis and serves to emphasize the danger of giving any penicillin analogue to patients with a history of pencillin-induced interstitial nephritis.
D000741:Anemia, Aplastic / Q000150:complications* / Q000188:drug therapy; D001806:Blood Urea Nitrogen; D002228:Carbenicillin / Q000009:adverse effects* / Q000627:therapeutic use; D002481:Cellulitis / Q000150:complications / Q000188:drug therapy; D003404:Creatinine / Q000097:blood; D004009:Dicloxacillin / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009254:Nafcillin / Q000009:adverse effects / Q000627:therapeutic use; D009395:Nephritis, Interstitial / Q000139:chemically induced*
D009254:Nafcillin; D003404:Creatinine; D004009:Dicloxacillin; D002228:Carbenicillin