[Kidney preservation by mechanical perfusion and by hypothermic storage: a comparative study].
72 dog kidneys were stored under hypothermia as described by COLLINS and SACKS between 24 and 72 hrs and then transplanted. The immediate function of the kidneys was measured by PAH and inulin clearances. 24 hrs proved to be the maximum safe preservation time with both methods. The immediate function of the kidneys stored under hypothermia could not be improved by the addition of furosemide to the flushing solution. These results were compared with those gained by mechanical perfusion of the organ: kidney function after 72 hrs of hypothermic mechanical perfusion was significantly better than after 24 hrs of hypothermic storage.
D000818:Animals; D004285:Dogs; D005665:Furosemide / Q000494:pharmacology; D007444:Inulin / Q000652:urine; D007668:Kidney / Q000187:drug effects / Q000502:physiology; D009926:Organ Preservation / Q000379:methods*; D010477:Perfusion; D012034:Refrigeration; D014021:Tissue Preservation / Q000379:methods*; D010130:p-Aminohippuric Acid / Q000652:urine
D005665:Furosemide; D007444:Inulin; D010130:p-Aminohippuric Acid
Nierenkonservierung durch maschinelle Perfusion und hypotherme Lagerung: Eine Vergleichsuntersuchung.