The danger of "yellow dyes" (tartrazine) to allergic subjects.
Oral administration of 50 mg tartrazine to 122 patients with a variety of allergic disorders caused the following reactions: general weakness, heatwaves, palpitations, blurred vision, rhinorrhoea, feeling of suffocation, pruritus and urticaria. There was activation of the fibrinolytic pathway as shown by reduction of plasminogen with high pre-kallikrein and low kallikrein values. Reduction in complement activity (CH50) was seen in three out of sixteen reactions.
D001391:Azo Compounds / Q000009:adverse effects*; D003165:Complement System Proteins; D004342:Drug Hypersensitivity / Q000209:etiology*; D005342:Fibrinolysis; D005503:Food Additives / Q000009:adverse effects*; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D013645:Tartrazine / Q000009:adverse effects*
D001391:Azo Compounds; D005503:Food Additives; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D003165:Complement System Proteins; D013645:Tartrazine