[Ocular blood flow of cats after local administration of pilocarpine, phenylephrine, and of a mixture of both drugs (author's transl)].
Radioactively labelled microspheres (size 15 micron) were used to determine the regional blood flow in cats before and 15, 30 and 45 minutes after unilateral drug administration. In four experimental groups, each consisting of five animals, two drops of the drug were administered into the conjunctival sac. The blood flow increased in both eyes after administration of 2% pilocarpine and of Glauko Biciron, a mixture of 2% pilocarpine and 0.06% phenylephrine. No significant differences in the regional blood flows between the treated and untreated eye were found. After administration of 2% phenylephrine a decrease in blood flow was observed in both eyes, however earlier and more pronounced in the left eye. Thus, phenylephrine evoked the expected vasoconstrictive effect on the treated side. In the control group, which received physiological salt solution, the blood flow on the treated side decreased in most tissues, while an increase was observed on the untreated side.
D000287:Administration, Topical; D000818:Animals; D002415:Cats; D004338:Drug Combinations; D005123:Eye / Q000098:blood supply*; D009883:Ophthalmic Solutions; D010656:Phenylephrine / Q000008:administration & dosage*; D010862:Pilocarpine / Q000008:administration & dosage*; D012039:Regional Blood Flow / Q000187:drug effects
D004338:Drug Combinations; D009883:Ophthalmic Solutions; D010862:Pilocarpine; D010656:Phenylephrine
Die Durchblutung des Katzenauges unter lokaler Verabreichung von Pilocarpin, Phenylephrin und einer Kombination beider Pharmaka.