[Effectiveness of orotic acid and calcium pangamate in experimental liver dystrophy].
In tests staged on albino rats with acute dystrophy of the liver provoked with carbon tetrachloride the effect of orotic acid and calcium pangamate on the functional state of the liver was studied. Combined application of orotic acid and calcium pangamate was found to promote a more complete restoration of an intensive secretion of bile, synthesis and secretion of cholates together with bile, formation and secretion of bilirubin, excretion of cholesterol than this could be achieved by separate application of these compounds.
D000208:Acute Disease; D000818:Animals; D001646:Bile / Q000187:drug effects / Q000378:metabolism; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D005260:Female; D008107:Liver Diseases / Q000188:drug therapy*; D009963:Orotic Acid / Q000627:therapeutic use*; D051381:Rats; D013997:Time Factors; D014803:Vitamin B Complex / Q000627:therapeutic use*
D014803:Vitamin B Complex; D009963:Orotic Acid
Effektivnost' orotovoĭ kisloty i pangamata kal'tsiia pri éksperimental'noĭ distrofii pecheni.