Structure of vancomycin and its complex with acetyl-D-alanyl-D-alanine.
Vancomycin, a broad-spectrum antibiotic, inhibits the growth of cell walls by complex formation with peptides terminating in D-alanyl-D-alanine. The structure of vancomycin was determined by X-ray analysis of the degradation product CDP-I. A model of the complex is proposed based on this study and spectroscopic data.
D004151:Dipeptides; D008958:Models, Molecular; D008968:Molecular Conformation; D014640:Vancomycin / Q000031:analogs & derivatives; D014961:X-Ray Diffraction
D004151:Dipeptides; D014640:Vancomycin