Inhibition of secretin-stimulated exocrine pancreatic secretion by diazoxide in the rat.
Diazoxide, a known insulin inhibitor, inhibits the pancreatic exocrine response to secretin in unanesthetized rats and does not modify the CCK-PZ-stimulated secretion. These results suggest that insulin may have a role on the stimulation of exocrine pancreas through secretin.
D000818:Animals; D002766:Cholecystokinin / Q000494:pharmacology; D003981:Diazoxide / Q000494:pharmacology*; D008297:Male; D010179:Pancreas / Q000378:metabolism*; D010189:Pancreatic Juice / Q000378:metabolism*; D051381:Rats; D012633:Secretin / Q000494:pharmacology*; D012636:Secretory Rate / Q000187:drug effects
D012633:Secretin; D002766:Cholecystokinin; D003981:Diazoxide