Determination of time course of tablet disintegration II: Method using continuous functions.
An analysis of the disintegration-dissolution sequence of drug release from a tablet leads to a mathematical expression relating disintegration to the dissolution profile of the tablet and the dissolution rate of the primary drug particles in the tablet. The equation describing the disintegration of an acetaminophen tablet is determined to demonstrate the application of the theory.
D000082:Acetaminophen; D002626:Chemistry, Pharmaceutical / Q000379:methods; D008956:Models, Chemical; D012995:Solubility; D013607:Tablets; D013997:Time Factors
D013607:Tablets; D000082:Acetaminophen