Generalization and simplification of the Moore-Goodman test for significant of alignment homologies.
A test given by Moore and Goodman (1977) that checks the significance of a homology between protein sequences is generalized to any type of distance measure and to any classification of codon pairs or amino acids according to this measure. A normal distribution is shown to approximate satisfactorily the probability distribution underlying this test for the examples chosen, and supposedly for any distance measure. The test accordingly reduces to a simple standard procedure.
D000595:Amino Acid Sequence; D005075:Biological Evolution; D003062:Codon; D008954:Models, Biological; D009154:Mutation; D011506:Proteins / Q000235:genetics*
D003062:Codon; D011506:Proteins