Calcitonin-mediated changes in plasma tryptophan and brain 5-hydroxytryptamine and acetylcholinesterase activity in rats.
After a single injection of calcitonin (20 M.R.C. units/kg body wt.) marked decreases in both Ca2+ and free tryptophan in plasma were observed, during the initial period of the treatment (up to 1 h). However, 5-hydrotryptamine contents of the whole brain and the cerebral acetylcholinesterase activity were greatly enhanced. The cerebellar acetylcholinesterase activity was not influenced by calcitonin.
D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology / Q000378:metabolism*; D001923:Brain Chemistry; D002116:Calcitonin / Q000494:pharmacology*; D002118:Calcium / Q000097:blood; D008297:Male; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D014364:Tryptophan / Q000097:blood*
D012701:Serotonin; D014364:Tryptophan; D002116:Calcitonin; D000110:Acetylcholinesterase; D002118:Calcium