Plasma protein binding of d-propoxyphene in normal subjects and anephric patients.
The free fraction of d-propoxyphene in the plasma of normal subjects is 0.24 +/- 0.02 (mean +/- S.D.) and is not concentration dependent in the usual therapeutic and toxic conentration range. Renal failure and relatively high concentrations of d-norpropoxyphene, the major metabolite of d-propoxyphene, have no significant effect on the plasma protein binding of d-propoxyphene.
D000328:Adult; D001798:Blood Proteins / Q000378:metabolism*; D011431:Dextropropoxyphene / Q000031:analogs & derivatives / Q000097:blood* / Q000494:pharmacology; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007668:Kidney / Q000502:physiology*; D007676:Kidney Failure, Chronic / Q000097:blood*; D008297:Male; D009392:Nephrectomy; D011485:Protein Binding / Q000187:drug effects
D001798:Blood Proteins; D011431:Dextropropoxyphene