[Effect of estrogen on interconversion of prostaglandin F and E in rat uterus (author's transl)].
To determine estrogen action in PG metabolism in rat uterus, effect of the hormone on the uptake and interconversion of PGF and E was studied using 3H-PGF2alpha and 3H-PGE2. The following results were obtained: Uptake of 3H-PGF2alpha and 3H-PGE2 was increased at 6 hours after estrogen injection. The conversion into PGF and PGE group from 3H-PGE2 and 3H-PGF2alpha, respectively, was observed in rat uterus, but the hormone action on the interconversion of PG was apparently different between PGF2alpha and PGE2. The conversion of 3H-PGF2alpha into PGE group was increased with the lapse of time after estrogen injection. However, estrogen action on the conversion of 3H-PGE2 into PGF group was not so remarkable as that of 3H-PGF2alpha. Effects of indomethacin in vivo and in vitro on the metabolism of PGF2alpha increased by estrogen were also examined. Estrogen action on the uptake of PGF group was inhibited by indomethacin injection, but the conversion into PGE was not influenced by this compound.
D000818:Animals; D004958:Estradiol / Q000494:pharmacology; D004965:Estrogen Antagonists; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D011458:Prostaglandins E / Q000378:metabolism*; D011460:Prostaglandins F / Q000378:metabolism*; D051381:Rats; D013268:Stimulation, Chemical; D013997:Time Factors; D014599:Uterus / Q000378:metabolism*
D004965:Estrogen Antagonists; D004967:Estrogens; D011458:Prostaglandins E; D011460:Prostaglandins F; D004958:Estradiol; D007213:Indomethacin