In vivo formation of dopamine from 3,4-methylenedioxyphenethylamine in the rat.
Administered 1-C14-3,4-methylenedioxyphenethylamine led to the excretion of about 2% of the urinary C14 as conjugated dopamine and 3-methoxytyramine metabolites, in tranylcypromine treated rats. The amine was not excreted unchanged. The major metabolites were identified as conjugates of methylenedioxyphenylacetic acid, homovanilic acid and dihydroxyphenylacetic acid. The latter are derived by the further metabolism of conjugated methylenedioxyphenylacetic acid. Administered tranylcypromine doubled the excretion of conjugates of labeled dopamine and3-methoxytyramine. NADPH served as a cofactor for the microsomal demethylenation of the amine.
D015104:3,4-Methylenedioxyamphetamine / Q000031:analogs & derivatives / Q000378:metabolism*; D000662:Amphetamines / Q000378:metabolism*; D000818:Animals; D001711:Biotransformation; D004298:Dopamine / Q000096:biosynthesis*; D066298:In Vitro Techniques; D008862:Microsomes, Liver / Q000378:metabolism; D051381:Rats
D000662:Amphetamines; C016575:3,4-methylenedioxyphenethylamine; D015104:3,4-Methylenedioxyamphetamine; D004298:Dopamine