Proton magnetic resonance spectroscopic determination of disulfiram: collaborative study.
A proton magnetic resonance spectroscopic method for determining disulfiram in the bulk drug product and in the formulated material was collaboratively studied. The method depends on the use of chloroform-d as a solvent and hexamethylcyclotrisiloxane as the internal standard. No interference from tablet excipients was observed. The method is rapid and specific. Eighteen laboratories analyzed duplicate samples of a bulk drug product, a 250 mg tablet composite, and a 500 mg tablet composite. The average per cent results and standard deviations were 99.7 +/- 1.4, 100.9 +/- 2.0, and 99.9 +/- 2.2, respectively.
D004221:Disulfiram / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy; D008722:Methods; D013607:Tablets / Q000032:analysis
D013607:Tablets; D004221:Disulfiram