Cytogenetic effects of myleran in vivo on bone-marrow cells from male mice.
The cytogenetic effects of Myleran were examined in bone-marrow cells from male mice. To study the dose--response relationship the male mice were injected with 5, 10, 20 or 40 mg of Myleran/kg. Bone-marrow samples were prepared 24 h later. The time response was investigated by examining bone-marrow samples 1, 2, 4 or 10 days after i.p. injection of 40 mg of Myleran. Most of the structural aberrations were of the chromatid type and the dose--response relationship was linear. The chromatid and chromosomal aberrations were maximal at 2 days and decreased sharply after longer intervals of time.
D000818:Animals; D001853:Bone Marrow / Q000648:ultrastructure; D002066:Busulfan / Q000494:pharmacology*; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D013997:Time Factors
D002066:Busulfan