Ion exchange method for determining mephentermine sulfate in drug formulations: collaborative study.
Ion exchange chromatography is used to separate mephentermine sulfate from drug formulations. The drug is subsequently measured by ultraviolet spectrophotometry. Assays on 4 commercial samples of tablets and injectables gave recoveries from 97.6 to 104% of declared. A collaborative study involving 2 tablet and 2 liquid formulations gave mean recoveries ranging from 94.7 to 99.3% and coefficients of variation from 1.39 to 2.00%.
D002852:Chromatography, Ion Exchange / Q000379:methods; D008616:Mephentermine / Q000032:analysis*; D012996:Solutions / Q000032:analysis; D013607:Tablets / Q000032:analysis; D014481:United States; D014486:United States Food and Drug Administration
D012996:Solutions; D013607:Tablets; D008616:Mephentermine