[Coumarin-necroses: An allergic reaction or a local Sanarelli-Shwartzman-phenomenon? (author's transl)].
In a 70-year old woman presenting with extended coumarin-necroses on her right thigh and shin histological findings, immunofluorescence and coagulation-parameters favoured a mechanism closely related to a local Sanarelly-Shwartzman-reaction. A primary immunological process involving the vessel walls could be ruled out.
D000368:Aged; D003374:Coumarins / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007866:Leg / Q000098:blood supply; D009336:Necrosis; D012790:Shwartzman Phenomenon / Q000139:chemically induced; D012867:Skin / Q000098:blood supply; D012871:Skin Diseases / Q000139:chemically induced*; D013924:Thrombophlebitis / Q000188:drug therapy
D003374:Coumarins
Cumarinnekrose Allergische Reaktion oder Ausdruck eines lokalen Sanarelli-Shwartzman-Phänomens?