Gastrin release in response to arginine infusion.
Intravenous infusion of arginine has been reported to be a powerful stimulus of endogenous gastrin release. This response has been re-examined in 12 normal human subjects. 6 of the subjects showed a 40% or greater rise in serum gastrin, and these responses were widely scattered in time. Changes in overall mean serum gastrin were small and showed a significant (p less than 0.05) rise over mean basal levels at only one point in time which was during arginine infusion. In this study arginine infusion resulted in a much smaller and less consistent serum gastrin response than previous reports.
D000328:Adult; D001120:Arginine / Q000494:pharmacology*; D005260:Female; D005755:Gastrins / Q000097:blood / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D010455:Peptides / Q000276:immunology; D011863:Radioimmunoassay; D013268:Stimulation, Chemical
D005755:Gastrins; D010455:Peptides; D001120:Arginine