Mutagenicity testing of 3 hallucinogens: LSD, psilocybin and delta 9-THC, using the micronucleus test.
Using the micronucleus test as a screening method for mutagenic activity, no significant increase in the number of micronuclei was found when LSD, psilocybin or delta 9-THC were administered in 3 logarithmically increasing doses to mice, Azathioiprine (Imuran), given as a positive control, caused a statistically significantt increase in the micronucleated cells.
D000818:Animals; D001379:Azathioprine / Q000494:pharmacology; D001853:Bone Marrow / Q000187:drug effects; D002869:Chromosome Aberrations / Q000187:drug effects; D013759:Dronabinol / Q000494:pharmacology*; D008238:Lysergic Acid Diethylamide / Q000494:pharmacology*; D051379:Mice; D009153:Mutagens; D011562:Psilocybin / Q000494:pharmacology*
D009153:Mutagens; D011562:Psilocybin; D013759:Dronabinol; D008238:Lysergic Acid Diethylamide; D001379:Azathioprine