Treatment of infantile subglottic hemangioma with radioactive gold grain.
Congenital subglottic hemangioma causes life-threatening airway obstruction during the first few months of life. The mortality rate of recognized and untreated cases justifies active treatment, and although radiation therapy is currently most favored, it carries a risk of inducing malignant change in the thyroid gland later in life. A series of 11 patients with laryngeal hemangiomata is reported, conventional radiotherapy was utilized in the first seven patients, and placement of a radioactive gold grain directly into the lesion was used in the last four patients. This technique offers maximal tumor dose with minimal thyroid gland irradiation compared to treatment by conventional radiotherapy, and its successful use in these four patients is reported as worthy of further trial.
D005260:Female; D006050:Gold Radioisotopes / Q000008:administration & dosage* / Q000627:therapeutic use; D006391:Hemangioma / Q000151:congenital / Q000532:radiotherapy*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007822:Laryngeal Neoplasms / Q000151:congenital / Q000532:radiotherapy*; D008297:Male
D006050:Gold Radioisotopes