Precursor lesions in familial melanoma. A new genetic preneoplastic syndrome.
In seven consecutive melanoma-prone families, pigmented lesions with distinctive clinical and histologic characteristics occurred in 18 of 20 melanoma patients (90%) and 24 of 43 first-degree relatives (56%). Recognition of these lesions led to the detection of early-stage melanoma in six family members. This syndrome appears to represent an autosomal dominant trait and may serve as a cutaneous marker to identify persons at high risk for melanoma.
D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000235:genetics* / Q000473:pathology; D010375:Pedigree; D011230:Precancerous Conditions / Q000473:pathology*; D012306:Risk; D012878:Skin Neoplasms / Q000235:genetics* / Q000473:pathology; D013577:Syndrome