Effect of anaesthetic agents on the ionic composition of cerebrospinal fluid following total cerebral ischaemia.
Total cerebral ischaemia in rats caused a marked increase in the cisternal CSF potassium concentration but little change in CSF sodium or chloride concentration. The anaesthetic techniques studied (pentobarbitone, halothane/oxygen and nitrous oxide/oxygen/relaxant) did not effect the potassium increase following cerebral ischaemia. We conclude that the mechanism of barbiturate protection following cerebral ischaemia is different from that of hypothermia.
D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D002712:Chlorides / Q000134:cerebrospinal fluid; D004573:Electrolytes / Q000134:cerebrospinal fluid*; D006221:Halothane / Q000494:pharmacology; D002546:Ischemic Attack, Transient / Q000134:cerebrospinal fluid*; D009609:Nitrous Oxide / Q000494:pharmacology; D010424:Pentobarbital / Q000494:pharmacology; D011188:Potassium / Q000134:cerebrospinal fluid; D051381:Rats; D012964:Sodium / Q000134:cerebrospinal fluid
D000777:Anesthetics; D002712:Chlorides; D004573:Electrolytes; D012964:Sodium; D010424:Pentobarbital; D009609:Nitrous Oxide; D011188:Potassium; D006221:Halothane