Toxic encephalopathy related to antihistamine-barbiturate antiemetic medication.
A toxic encephalopathy characterized by depressed level of consciousness, marked irritability, and ataxia developed in seven children, 5 years of age and younger, following administration of an antiemetic combination of pentobarbital and pyrilamine maleate. Three of the seven patients were given a dosage of medication and exceeding the manufacture's recommendation. All seven patients recovered without sequelae.
D001927:Brain Diseases / Q000139:chemically induced*; D002675:Child, Preschool; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010424:Pentobarbital / Q000008:administration & dosage / Q000009:adverse effects*; D011725:Pyridines / Q000009:adverse effects*; D011738:Pyrilamine / Q000008:administration & dosage / Q000009:adverse effects*; D014839:Vomiting / Q000188:drug therapy
D004338:Drug Combinations; D011725:Pyridines; D011738:Pyrilamine; D010424:Pentobarbital