Dose dependency of the post-insult protective effect of pentobarbital in the canine experimental stroke model.
In a canine stroke model, dose dependent protection by postocclusion pentobarbital was suggested from 10--40 mg/kg. In 28 dogs investigated (10 from a previous study) a distinct, significant reduction in right cerebral hemisphere infarction occurred in animals given 15--20 mg/kg pentobarbital intramuscularly 1 hour postocclusion. Increased dosages did not alter statistically the infarct size and 2 dogs at the 50 mg/kg and 80 mg/kg levels died of barbiturate-induced respiratory failure.
D000818:Animals; D002561:Cerebrovascular Disorders / Q000517:prevention & control*; D004195:Disease Models, Animal; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D002542:Intracranial Embolism and Thrombosis / Q000517:prevention & control; D010424:Pentobarbital / Q000008:administration & dosage / Q000494:pharmacology*
D010424:Pentobarbital