Leukemoid reaction in BALB/c mice bearing primary tumors induced by 3-methylcholanthrene.
During the growth of five of ten primary tumors that were induced by 3-methylcholanthrene in BALB/cMk and BALB/cMk X C57BL/6F1 mice, leukemoid reactions, characterized by increase in number of granulocytes in peripheral blood, and splenomegaly were observed. However, no such reactions occurred in five C57BL/6 mice bearing primary tumors induced by 3-methylcholanthrene. The results of leukemoid reactions in mice bearing 3-methylcholanthrene-induced primary tumors are compared with the reactions found in mice bearing transplanted tumors.
D000818:Animals; D005260:Female; D007942:Leukemia, Experimental / Q000097:blood / Q000209:etiology* / Q000473:pathology; D008297:Male; D008748:Methylcholanthrene; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D009378:Neoplasms, Multiple Primary / Q000209:etiology*; D012513:Sarcoma, Experimental / Q000139:chemically induced*; D013045:Species Specificity; D014184:Transplantation, Homologous; D014185:Transplantation, Isogeneic
D008748:Methylcholanthrene