Quantitative determination of chlorpromazine. HCl in tablets, spansules, injectables, and bulk chemical by nuclear magnetic resonance spectroscopy.
A nuclear magnetic resonance (NMR) procedure is described for the quantitative analysis of chlorpromazine. HCl in bulk chemical as well as in final dosage forms--tablets, spansules, and injectables. The method is based on measurement of a characteristic signal of chlorpromazine relative to an internal standard. Three different internal standards are specified: Cyclohexane was selected because of the convenience and rapidity with which samples could be prepared for assay. Piperonal was used to verify the method and to show that precision and accuracy were not affected by the volatility of the cyclohexane. Tetramethylammonium bromide was used as an internal standard for Thorazine injectable. No interferences were found from stearates and other tablet excipients. The NMR procedure provides a simple, direct, and specific assay with a precision of +/- 1-2%.
D002214:Capsules / Q000032:analysis; D002746:Chlorpromazine / Q000008:administration & dosage / Q000032:analysis*; D007267:Injections; D009682:Magnetic Resonance Spectroscopy; D008722:Methods; D012996:Solutions / Q000032:analysis; D013607:Tablets / Q000032:analysis
D002214:Capsules; D012996:Solutions; D013607:Tablets; D002746:Chlorpromazine