Reduced frequencies of mitomycin-C induced sister chromatid exchanges in AKR mice.
The frequencies of base-line and Mitomycin-C (MMC) induced sister chromatid exchanges (SCE) were surveyed in four inbred strains of mice. In contrast to the C57Bl/6J, CBA/J, and A/J strains where frequencies of SCE increased linearly with increasing dose of MMC, levels of SCE were significantly lower in AKR/J mice at high MMC concentrations. At a dose of 5 mg/kg MMC, chromosomal aberrations were more frequent in bone marrow cells of AKR/J mice than in C57Bl/6J mice. These observations suggest an altered response to DNA damage in the AKR mouse strain.
D000818:Animals; D001853:Bone Marrow / Q000473:pathology; D002842:Chromatids; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR / Q000235:genetics*; D008810:Mice, Inbred C57BL / Q000235:genetics; D008808:Mice, Inbred CBA / Q000235:genetics; D008937:Mitomycins
D008937:Mitomycins