Cerebromedullospinal disconnection after intraventricular methotrexate.
A case of cerebromedullospinal disconnection or "locked-in" syndrome after intraventricular methotrexate is described. This is an unusual complication of intraventricular methotrexate instillation. Ventral pontine infarction is postulated to be responsible for the syndrome.
D001927:Brain Diseases / Q000139:chemically induced*; D002277:Carcinoma / Q000188:drug therapy; D005260:Female; D006801:Humans; D007276:Injections, Intraventricular; D008577:Meningeal Neoplasms / Q000188:drug therapy; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D010264:Paraplegia / Q000139:chemically induced*; D013577:Syndrome
D008727:Methotrexate