Therapeutic studies in NZB/NZW mice. VI. Age-dependent effects of concanavalin A stimulated spleen cell supernate.
Spleen cells from normal mice were cultured with Concanavalin A to produce an immunosuppressive supernate. This supernate was used to treat the lupus-like autoimmune disease of NZB/NZW mice. Such treated mice lived significantly longer than did controls, but only if treatment was initiated early in the course of the illness.
D000367:Age Factors; D000818:Animals; D001327:Autoimmune Diseases / Q000628:therapy; D002457:Cell Extracts / Q000627:therapeutic use*; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology*; D005069:Evaluation Studies as Topic; D005260:Female; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D066298:In Vitro Techniques; D008180:Lupus Erythematosus, Systemic / Q000628:therapy*; D051379:Mice; D008815:Mice, Inbred Strains; D008970:Molecular Weight; D013154:Spleen / Q000166:cytology; D013268:Stimulation, Chemical; D013997:Time Factors; D014020:Tissue Extracts / Q000627:therapeutic use*
D002457:Cell Extracts; D007166:Immunosuppressive Agents; D014020:Tissue Extracts; D003208:Concanavalin A