Ascorbate stimulation of salicylate absorption in isolated rat intestine.
Salicylate transport across the rat intestine was measured using both in vitro and in vivo procedures. After the steady state for labeled salicylate was reached, the addition of ascorbate stimulated tracer flux with the establishment of a new steady state. The tissue permeability had a saturable dependence on ascorbate concentration. Also, ascorbate stimulated the tissue short-circuit current.
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D004553:Electric Conductivity; D066298:In Vitro Techniques; D007408:Intestinal Absorption / Q000187:drug effects*; D007422:Intestines / Q000502:physiology; D008297:Male; D010539:Permeability; D051381:Rats; D012459:Salicylates / Q000378:metabolism*; D013268:Stimulation, Chemical
D012459:Salicylates; D001205:Ascorbic Acid