Liver support systems: the low clearance of model hepatic excretory anions by charcoal hemoperfusion.
The removal of cholephilic anions (unconjugated bilirubin, bromosulfophthalein, and indocyanine green) by charcoal hemoperfusion was assessed in normal dogs. None of these model excretory compounds was effectively removed by the charcoal columns. In vitro studies suggested that poor removal of the anions was related to albumin binding in that, when the anions were in molecular solution, their extraction by the charcoal column was high; however, when albumin was added, their extraction was negligible. Therefore, if the removal from plasma of strongly bound toxins is important in the treatment of acute hepatitic failure, additional support devices may have to be encompassed into the ultimately hepatic support system.
D000818:Animals; D000838:Anions; D001663:Bilirubin / Q000097:blood; D002606:Charcoal / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004285:Dogs; D004573:Electrolytes / Q000097:blood*; D005260:Female; D006464:Hemoperfusion / Q000379:methods*; D006501:Hepatic Encephalopathy / Q000097:blood / Q000628:therapy*; D007208:Indocyanine Green / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D011485:Protein Binding; D013448:Sulfobromophthalein / Q000378:metabolism
D000838:Anions; D004573:Electrolytes; D013448:Sulfobromophthalein; D002606:Charcoal; D007208:Indocyanine Green; D001663:Bilirubin