[Insulin activity of blood plasma in fetuses and newborn infants with asphyxia. Effect of insulin on the course of hypoxia and elimination of its sequelae under experimental conditions].
In this clinico-experimental work data are presented concerning the blood plasma insulin activity in mature fetuses and neonates in asphyxia; the influence of insulin on the course of hypoxia and elimination of its sequelae under experimental conditions on the newborn and sexually mature rats was also noted. The blood plasma insulin activity proved to increase in the neonates born of mothers with normally coursing pregnancy. A statistically significant reduction of the insulin activity was noted in neonates whose mothers suffered from toxemia of the second half of pregnancy. The death of fetuses and neonates was accompanied by a marked reduction of the blood plasma insulin activity. Preliminary administration of insulin increased the tolerance of experimental animals to hypoxia. Administration of insulin at the period of normalization of physiological functions after hypoxia produced a positive influence on the animal revival. Data are presented on the mechanism of insulin action in hypoxia.
D000818:Animals; D001238:Asphyxia Neonatorum / Q000097:blood* / Q000517:prevention & control; D005260:Female; D005311:Fetal Hypoxia / Q000097:blood* / Q000517:prevention & control; D006801:Humans; D007231:Infant, Newborn; D007328:Insulin / Q000097:blood* / Q000172:deficiency / Q000627:therapeutic use; D011247:Pregnancy; D051381:Rats
D007328:Insulin
Insulinovaia aktivnost' plazmy krovi u plodov i novorozhdennykh pri gipoksii. Vliianie insulina na techenie gipoksii i likvidatsiiu ee posledstvii v eksperimente.