Fenoprofen: drug form selection and preformulation stability studies.
Several fenoprofen salts were prepared to obtain the most acceptable form for an oral dosage formulation. Thermal analysis techniques were used to compare stabilities of the water of hydration in different salt forms and to assess the effects of the water of hydration on compatibility with propoxyphene and codeine salts. Photodegradation products of fenoprofen were isolated and identified, and their relevance to product formulation was evaluated.
D000588:Amines / Q000138:chemical synthesis; D002626:Chemistry, Pharmaceutical; D004055:Differential Thermal Analysis; D004355:Drug Stability; D005279:Fenoprofen / Q000138:chemical synthesis / Q000528:radiation effects; D006813:Humidity; D008027:Light; D010666:Phenylpropionates / Q000138:chemical synthesis / Q000528:radiation effects; D012995:Solubility; D013818:Thermogravimetry
D000588:Amines; D010666:Phenylpropionates; D005279:Fenoprofen