Myxedema myopathy: a case report.
A classical case of myxedema, demonstrating the typical Hoffmann syndrome (muscle weakness, hypertrophy, pseudomyotonic phenomena) and the usual rise in serum creatine phosphokinase (CPK), is discussed. Assuming that there is a CPK loss in the muscle fiber, the pseudomyotonic phenomena may be due to an increase in ADP, which in turn inhibits the calcium pump. Furthermore, light-microscopic and electron-microscopic findings are reported.
D000244:Adenosine Diphosphate / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D003402:Creatine Kinase / Q000378:metabolism; D006801:Humans; D006984:Hypertrophy; D008297:Male; D008875:Middle Aged; D009120:Muscle Cramp / Q000378:metabolism / Q000473:pathology; D009132:Muscles / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D009135:Muscular Diseases / Q000378:metabolism / Q000473:pathology; D009230:Myxedema / Q000378:metabolism / Q000473:pathology; D013577:Syndrome
D000244:Adenosine Diphosphate; D003402:Creatine Kinase; D002118:Calcium