Lowered oxygen consumption and heart rate as early symptoms of the obese-hyperglycemic syndrome in mice (ob/ob).
Latent obese-hyperglycemic mice exhibit significantly subnormal heart rate and level of oxygen consumption as early as three and eight days post-partum, respectively. Also, loss of body weight during a three-hour fasting period is detectably less extreme in obese than in normal litter mates as early as five days post-partum. Regression analysis of the differences between the latent obese and normal litter mates suggests that these symptoms begin developing at birth.
D000367:Age Factors; D000818:Animals; D001835:Body Weight; D005215:Fasting; D006339:Heart Rate; D006943:Hyperglycemia / Q000503:physiopathology*; D051379:Mice; D008820:Mice, Obese; D009765:Obesity / Q000503:physiopathology*; D010100:Oxygen / Q000097:blood*
D010100:Oxygen