[Hepatic cholestasis].
In a series of 212 liver biopsies which had been subjected to ultrastructural examination, the picture of cholestasis was encountered in 60 cases. In 32 cases it was associated with subhepatal obtruction. The reminder included hepatitis, hepatic fibrosis and cirrhosis and other diseases. Experiments in rats showed that the main findings following the ligature of choledochus included oedema and disintegration of mucosal microvilli in the bile ducts. Such changes preceded those of the hepatocytes. Simple overload by parenteral bilirubin did not evoke comparable changes. Therefore the mechanical disturbance of the epithelial wall of the bile ducts has been regarded as the basic changes subjected to later secondary modifications.
D001706:Biopsy; D002779:Cholestasis / Q000473:pathology*; D006801:Humans; D008099:Liver / Q000473:pathology* / Q000648:ultrastructure; D008854:Microscopy, Electron
Cholestáza jater.