[Effect of interferon-inducing complex on thymidine 3H-labeling of DNA, RNA and proteins of marrow cells after total X-irradiation of mice].
Interferonogen is shown to intensify the RNA synthesis only slightly, practically having effect neither on DNA synthesis nor on protein one. Interferonogen administered 2h before irradiation impedes development of the pronounced inhibition of DNA, first of all. Basing on the fact that the mentioned regularities were manifested at the early stages of the post radiation period (up to 3-4 h) and coming from the previously established radioprojection efficiency of interferonogen it is supposed that interferonogenesis takes part in regulation of the cell reparation systems.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects*; D004247:DNA / Q000096:biosynthesis* / Q000528:radiation effects; D007369:Interferon Inducers / Q000494:pharmacology*; D007700:Kinetics; D051379:Mice; D014176:Protein Biosynthesis; D011506:Proteins / Q000528:radiation effects; D012313:RNA / Q000096:biosynthesis* / Q000528:radiation effects; D013936:Thymidine / Q000378:metabolism
D007369:Interferon Inducers; D011506:Proteins; D012313:RNA; D004247:DNA; D013936:Thymidine
Vliianie interferonogennogo kompleksa na vkliuchenie mechenykh predshestvennikov v DNK, RNK i belki kletok kostnogo mozga posle obshchego rentgenovskogo oblucheniia mysheĭ.