Possible phenylethylmalondiamide (PEMA) intoxication.
We have encountered a case of apparent intoxication with primidone (Mysoline) in a patient with severe renal impairment. Of interest were high serum levels of phenylethyl-malondiamide (PEMA), a metabolite of primidone.
D000328:Adult; D001711:Biotransformation; D005260:Female; D006207:Half-Life; D006801:Humans; D008314:Malonates / Q000506:poisoning*; D010657:Phenylethylmalonamide / Q000097:blood / Q000506:poisoning*; D011324:Primidone / Q000097:blood / Q000506:poisoning* / Q000627:therapeutic use; D014402:Tuberous Sclerosis / Q000097:blood / Q000188:drug therapy
D008314:Malonates; D011324:Primidone; D010657:Phenylethylmalonamide