[Effect of long-term administration of thyroxine on the content of nucleic acids and certain indicators of phosphorus metabolism in the liver in experimental thyrotoxicosis].
In the liver of albino rats with experimental thyrotoxicosis a study was made of nucleic acids and some indices of phosphorus metabolism: total and inorganic phosphorus, total and acid-soluble phosphorus, phosphorus of RNA, DNA and phosphoproteins. A significant elevation of the RNA and DNA content was noted 1 1/2 months from the beginning of the experiment. An increase of the concentration of nucleic acid phosphorus and a simultaneous reduction of the content of phosphorus of phosphoproteins and inorganic phosphorus was noted in the phosphorus metabolism indices under study. The content of total and acid-soluble phosphorus displayed no significant change. The data obtained indicated that, along with increased catabolism in thyrotoxicosis there occurred rather intensive synthesis, without reaching the normal level, however.
D000818:Animals; D004247:DNA / Q000378:metabolism*; D006980:Hyperthyroidism / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D010750:Phosphoproteins / Q000378:metabolism; D010758:Phosphorus / Q000378:metabolism*; D012313:RNA / Q000378:metabolism*; D051381:Rats; D013974:Thyroxine / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
D010750:Phosphoproteins; D010758:Phosphorus; D012313:RNA; D004247:DNA; D013974:Thyroxine
Vliianie prodolzhitel'nogo vvedeniia tiroksina na soderzhanie nukleinovykh kislot i nekotorykh pokazateleĭ fosfornogo obmena v pecheni pri eksperimental'nom tireotoksikoze.