Radionuclide imaging of primary renal-cell carcinoma by I-131-labeled antitumor antibody.
A goat antibody against human renal-cell carcinoma reacted on immunofluorescence with renal-cell carcinomas from 20 patients, but not with normal adult human tissues, including kidney. After i.v. administration the I-131-linked antibody showed preferential tumor localization in six of seven patients with primary renal carcinoma. Labeled antitumor antibodies may have the specificity for tumor imaging that current radiopharmaceuticals lack.
D000230:Adenocarcinoma / Q000000981:diagnostic imaging* / Q000276:immunology; D000818:Animals; D000912:Antibodies, Neoplasm; D006041:Goats / Q000276:immunology; D006801:Humans; D007457:Iodine Radioisotopes; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging* / Q000276:immunology; D011877:Radionuclide Imaging
D000912:Antibodies, Neoplasm; D007457:Iodine Radioisotopes