[Adrenal function after long term treatment with beclomethasone dipropionate in childhood asthma (author's transl)].
Evaluating plasma levels of cortisol and corticosterone after ACTH-stimulation, and the urinary metabolites tetrahydrocortisone and tetrahydrocortisol in asthmatic children it could be demonstrated, that in most cases there was no suppression of adrenal function following treatment over 6 to 18 months with a daily dose of 200 to 300 microgram beclomethasone dipropionate. Since in a few patients suppression was found, an ACTH stimulation after a six months treatment is recommended.
D000293:Adolescent; D000302:Adrenal Cortex / Q000187:drug effects*; D001249:Asthma / Q000188:drug therapy*; D001507:Beclomethasone / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003345:Corticosterone / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D013760:Tetrahydrocortisol / Q000652:urine; D013761:Tetrahydrocortisone / Q000652:urine
D013761:Tetrahydrocortisone; D013760:Tetrahydrocortisol; D001507:Beclomethasone; D003345:Corticosterone; D006854:Hydrocortisone
Nebennierenrindenfunktion nach Langzeitbehandlung mit Beclometasondipropionat (BDP) beim kindlichen Asthma Bronchiale.