Prevention of acute gastric ulceration in the rat by cimetidine, a histamine H2-receptor antagonist.
1. Intraperitoneal injections of cimetidine into rats markedly reduced gastric acid production. When given at a dose of 50 mg/kg body weight, rate of acid production fell from a mean of 2.73 mumol/min (s.d. = 0.32) to a lowest level of 0.81 (s.d. = 0.28): the difference was highly significant (P less than 0.005). When given in a dose of 100 mg/kg, the rate of acid production further fell to 0.18 mumol/min (s.d. = 0.12;P less than 0.001). 2. Treatment with cimetidine in doses of 100 mg/kg 8-hourly during a 24 h period of restraint prevented the development of acute gastric ulceration in the rat. Pretreatment with cimetidine also protected against the ulcerogenic effects of intragastrically administered bile or lysolecithin. 3. The marked sustained reduction of acid production most probably accounts for the protective effects of cimetidine against ulcer production in the rat stomach.
D000818:Animals; D001646:Bile / Q000502:physiology; D002927:Cimetidine / Q000494:pharmacology / Q000627:therapeutic use*; D005750:Gastric Juice / Q000378:metabolism; D006146:Guanidines / Q000627:therapeutic use*; D008244:Lysophosphatidylcholines / Q000494:pharmacology; D008297:Male; D051381:Rats; D012149:Restraint, Physical; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*
D006146:Guanidines; D008244:Lysophosphatidylcholines; D002927:Cimetidine