Prevention of ionizing radiation-induced liver microcirculation changes by the use of flow improvers.
Platelet aggregation and adhesiveness, as well as TpO2 responses to hypoxia were measured as microcirculation parameters in beagle dogs subject to Co60 ionizing radiation to a dose of 4600 rads in 5 weeks. Simultaneously, changes in blood chemistry and coagulation were also determined. Marked changes in all studied parameters in the post radiation period lead to the conclusion that the radiation liver damage, which is at least in part mediated through microcirculation disturbances, can be prevented with the flow improver, Rheomacrodex.
D000818:Animals; D003037:Cobalt Radioisotopes; D003911:Dextrans / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D008099:Liver / Q000098:blood supply*; D008833:Microcirculation / Q000187:drug effects / Q000528:radiation effects*; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption; D010973:Platelet Adhesiveness / Q000187:drug effects; D010974:Platelet Aggregation / Q000187:drug effects
D003037:Cobalt Radioisotopes; D003911:Dextrans; D010100:Oxygen