Effect of p-hydroxyacetanilide, sodium sulfate, and L-methionine on the leukemogenicity of N-[4-(5-nitro-2-furyl)-2-thiazolyl]acetamide.
Dietary administration of N-[4-(5-nitro-2-furyl)-2-thiazolyl]acetamide to mice for 14 weeks followed by 16 weeks of control diet resulted in a high incidence of lymphocytic leukemia and a low incidence of forestomach squamous cell papillomas. The coadministration of p-hydroxyacetanilide at a dose of 1.0% with either 250 or 500 ppm of N-[4-(5-nitro-2-furyl)-2-thiazolyl]acetamide resulted in inhibition of leukemogenesis, whereas when p-hydroxyacetanilide was coadministered with 1000 ppm of N-[4-(5-nitro-2-furyl)-2-thiazolyl]acetamide the leukemia incidence was not significantly reduced, but the latent period was prolonged. When sodium sulfate was administered with p-hydroxyacetanilide and N-[4-(5-nitro-2-furyl)-2-thiazolyl]acetamide, leukemogenesis was partially restored. L-Methionine, fed in place of sodium sulfate, unblocked leukemogenicity inhibition by p-hydroxyacetanilide. None of these chemicals, p-hydroxyacetanilide, sodium sulfate, or L-methionine, significantly affected the incidence of forestomach papillomas induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]acetamide, although tumor incidences in all groups were low. p-Hydroxyacetanilide and sodium sulfate had no significant effect on the high incidence of stomach tumors induced by formic acid 2-[4-(5-nitro-2-furyl)-2-thiazolyl]hydrazide or bladder tumors induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide.
D000083:Acetanilides / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D002273:Carcinogens; D004347:Drug Interactions; D005260:Female; D006834:Hydrazines; D007942:Leukemia, Experimental / Q000139:chemically induced* / Q000517:prevention & control; D007945:Leukemia, Lymphoid / Q000139:chemically induced; D051379:Mice; D009581:Nitrofurans; D010212:Papilloma / Q000139:chemically induced; D013274:Stomach Neoplasms / Q000139:chemically induced; D013431:Sulfates / Q000494:pharmacology*; D013844:Thiazoles; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced
D000083:Acetanilides; D002273:Carcinogens; D006834:Hydrazines; D009581:Nitrofurans; D013431:Sulfates; D013844:Thiazoles