Ultrastructural effects of 6-hydroxy-dopamine and 5, 6-dihydroxytryptamine on the central nervous system of fresh-water mussel, Anodonta cygnea L.
Ultrastructural effects of 6-hydroxydopamine and 5, 6-dihydroxytryptamine treatments were investigated in the central nervous system of fresh-water mussel. Two days after the treatments, the following characteristic find-structural alterations could be observed in the neuropil of the ganglia: frequent occurrence of multilamellar bodies, lysosomatic structures and elongated tubular forms; shrinking of varicose axon profiles with an enchancement of the density of the axoplasm and clumping of its content; abnormal swelling of certain axons in the neuropil. This degenerative process was accompanied by an intense phagocytosis. The damages evoked by the employed "false transmitters" in the mussel ganglia were, in general, similar to those found in vertebrates. Statistical analysis of the vesicle population of ganglia suggests the intragranular uptake of 6-hydroxydopamine and 5, 6-dihydroxytryptamine and, in addition, the role of dense-core vesicles of different types in the storage of both serotonin and catecholamines. Perikarya composing the cortical layer of the ganglia were not affected by the "false transmitters". This shows that different parts of a mussel neuron are differently sensitive to 6-hydroxydopamine and 5, 6-dihydroxytryptamine.
D015115:5,6-Dihydroxytryptamine / Q000494:pharmacology*; D000818:Animals; D001369:Axons / Q000648:ultrastructure; D049872:Bivalvia / Q000187:drug effects*; D005724:Ganglia / Q000187:drug effects* / Q000648:ultrastructure; D006892:Hydroxydopamines / Q000494:pharmacology*; D009474:Neurons / Q000648:ultrastructure; D010587:Phagocytosis / Q000187:drug effects
D006892:Hydroxydopamines; D015115:5,6-Dihydroxytryptamine