[Renal toxicity of the association: gentamicin/furosemide. One case (author's transl)].
The association in therapeutic doses of gentamicin and furosemide resulted, in a young patient suffering from post-B virus hepatitis cirrhosis, in renal insufficiency which was spontaneously regressive when the drugs were stopped. Gentamicin, used without furosemide, was not associated with any impairment of renal function. A review of the literature indicates a number of pathogenic hypotheses to explain the increased nephrotoxicity of this drug combination.
D000328:Adult; D004359:Drug Therapy, Combination; D005665:Furosemide / Q000009:adverse effects*; D005839:Gentamicins / Q000009:adverse effects*; D006509:Hepatitis B / Q000150:complications; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced*; D008103:Liver Cirrhosis / Q000188:drug therapy / Q000209:etiology; D008297:Male
D005839:Gentamicins; D005665:Furosemide
Toxicité rénale de l'association gentamicine-furosémide. Une observation.