Characterization of tin-technetium colloid in technetium-labeled albumin preparations.
The Tc-99m human serum albumin (HSA) system has been reinvestigated with gel filtration as the assay method. Other than Tc-99m HSA, two radioactive components have been isolated by this technique. Both components are tin-technetium colloids of differing particle sizes, and the relative quantity of each one is pH-dependent. The colloid has been further characterized by protein-induced x-ray emission analysis (PIXE) and by tissue distribution in rats. By this gel-filtration method, commercial Tc-99m HSA kits have been evaluated and have revealed varying amounts of colloids present.
D000818:Animals; D003102:Colloids; D007553:Isotope Labeling / Q000592:standards*; D008297:Male; D010084:Oxidation-Reduction; D051381:Rats; D012709:Serum Albumin; D013667:Technetium; D014001:Tin
D003102:Colloids; D012709:Serum Albumin; D013667:Technetium; D014001:Tin