Chemotherapy studies of various nitrosoureas: prevention of development of ethylnitrosourea-induced tumors in the nervous system.
Of four nitrosoureas administered to F344 rats that were offspring of mothers treated with ethylnitrosourea during pregnancy, 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea and its methyl derivative were particularly effective in blocking tumor development.
D000818:Animals; D001932:Brain Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D005038:Ethylnitrosourea; D005260:Female; D009374:Neoplasms, Experimental / Q000517:prevention & control; D009588:Nitrogen Mustard Compounds; D009607:Nitrosourea Compounds / Q000627:therapeutic use*; D011247:Pregnancy; D051381:Rats; D011916:Rats, Inbred F344
D009588:Nitrogen Mustard Compounds; D009607:Nitrosourea Compounds; D005038:Ethylnitrosourea