[Selection of active strains of Actinomadura carminata, the producer of carminomycin].
The method of selecting active strains among a definite group of analogue-resistant mutants was used on the basis of studying the dependence of the carminomycin-producing organism growth and the antibiotic synthesis level on some metabolites. As a result, gamma-ray induced mutants 4 times more active than the parent strains were obtained.
D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis*; D002360:Carubicin / Q000096:biosynthesis*; D003470:Culture Media; D009154:Mutation / Q000187:drug effects / Q000528:radiation effects; D009615:Nocardia / Q000235:genetics* / Q000378:metabolism; D012641:Selection, Genetic / Q000187:drug effects / Q000528:radiation effects; D013171:Spores, Bacterial / Q000187:drug effects / Q000528:radiation effects
D000903:Antibiotics, Antineoplastic; D003470:Culture Media; D002360:Carubicin
Selektsiia aktivnykh shtammov Actinomadura carcminata--produtsenta karminomitsina.