Analysis of the prodrug 7-acetylacroninium perchlorate in presence of the parent compound acronine.
Analysis of acronine and the prodrug acetylacroninium perchlorate in parenteral solutions is described. The unstable prodrug reacts quantitatively with the nucleophilic agent aniline by an unusual mechanism to form a phenylimino derivative of acronine. This derivative and acronine itself were determined by a spectrophotometric two-component method.
D000175:Acronine / Q000031:analogs & derivatives / Q000032:analysis* / Q000138:chemical synthesis; D000470:Alkaloids / Q000032:analysis*; D002855:Chromatography, Thin Layer; D004347:Drug Interactions; D008027:Light; D013053:Spectrophotometry
D000470:Alkaloids; D000175:Acronine