Calcium metabolism in lithium-treated patients. Relation to uni-bipolar dichotomy.
The bone mineral content (BMC) together with biochemical indices of calcium metabolism were measured in 83 manic-depressive patients on long-term lithium therapy. The patients were diagnosed and divided into a unipolar and a bipolar group according to strict symptomatic course criteria. The patients with bipolar course had a significantly decreased BMC (88% of normal, P is less than 0.001), while the unipolar patients had normal BMC. Both groups had biochemical changes consistent with primary hyperparathyroidism.
D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000188:drug therapy*; D001842:Bone and Bones / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D005260:Female; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000139:chemically induced; D008094:Lithium / Q000009:adverse effects* / Q000627:therapeutic use; D008274:Magnesium / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D008094:Lithium; D008274:Magnesium; D002118:Calcium