Selective inhibition of protein synthetic activity of cerebral membrane-bound ribosomes as a consequence of ethanol ingestion.
Ethanol ingestion by weanling rats results in an inhibition of protein synthetic activity of cerebral membrane-bound ribosomes. Among various amino acids tested, the incorporation of serine was inhibited to a maximum degree. In contrast to membrane-bound ribosomes, the activity of free ribosomes was enhanced as a consequence of ethanol treatment. Aminoacylation of tRNA in pH 5 fraction was also reduced in the brain cortices of ethanol-fed animals.
D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000648:ultrastructure; D003864:Depression, Chemical; D000431:Ethanol / Q000494:pharmacology*; D008297:Male; D008566:Membranes / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D012343:RNA, Transfer / Q000378:metabolism; D051381:Rats; D012269:Ribosomal Proteins / Q000096:biosynthesis*; D012270:Ribosomes / Q000187:drug effects / Q000378:metabolism*
D000596:Amino Acids; D009419:Nerve Tissue Proteins; D012269:Ribosomal Proteins; D000431:Ethanol; D012343:RNA, Transfer