[Could the outcome of therapy of deep thrombophlebitis be improved with a combination of surgical thrombectomy and regional fibrinolysis?].
A new mode of treatment of extensive acute and subacute deep venous thrombosis of the lower extremities is introduced. For this purpose the beneficial effects of surgical thrombectomy and of thrombolysis with streptokinase are combined during the course of a single surgical intervention. Rapid-flow regional perfusion is the vehicle used for administration of streptokinase and probably represents the third arm of this therapeutic approach by adding a hemodynamic wash-out effect. Because the thrombolytic agent is rinsed out of the circuit at the end of regional perfusion the usual side effects and contra-indications of this drug are avoided. Early and late results of this treatment are assessed clinically and with repeat venograms in a group of six unselected patients. Highly satisfactory results were obtained in four patients with complete anatomical and functional restoration of deep veins along their entire length in three cases. It is felt that continued use of this method is warranted.
D000328:Adult; D005260:Female; D005342:Fibrinolysis; D006801:Humans; D008722:Methods; D010477:Perfusion; D010690:Phlebography; D013300:Streptokinase / Q000627:therapeutic use; D013924:Thrombophlebitis / Q000601:surgery*
D013300:Streptokinase
Können die Behandlungsergebnisse bei tiefer Thrombophlebitis verbessert werden durch Kombination von chirurgischer Thrombektomie und regionaler Fibrinolyse?