An electron microscopic study of the origin of osteoblasts in implants of demineralized bone matrix.
Correlated light microscope and ultrastructural observations of allogeneic intramuscular implants of rat demineralized bone matrix demonstrate the interrelationships between various osteogenetic and non-osteogenetic cell types and suggest that the bone morphogenetic response is evoked from cells of a common origin. Endothelial cells may play a prominent, essential, as well as primary role in the bone morphogenetic response.
D000818:Animals; D001846:Bone Development; D001857:Bone Matrix / Q000648:ultrastructure*; D003593:Cytoplasm / Q000648:ultrastructure; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D006056:Golgi Apparatus / Q000648:ultrastructure; D008854:Microscopy, Electron; D008928:Mitochondria / Q000648:ultrastructure; D009024:Morphogenesis; D010000:Osteitis / Q000473:pathology; D010006:Osteoblasts / Q000648:ultrastructure*; D010010:Osteoclasts / Q000648:ultrastructure; D051381:Rats