Consequence of cerulenin-released beta-lactamase in clinical coliforms.
Periplasmic beta-lactamase of certain clinical coliforms was released, without affecting cell viability, by perturbation of the outer membrane utilizing the fatty acid-mimicking antibiotic cerulenin. Release of such compartmentalized beta-lactamase, at high population density, seems to provide an extra margin of resistance to the organisms against cephaloridine.
D000935:Antifungal Agents / Q000494:pharmacology*; D002509:Cephaloridine / Q000494:pharmacology; D002510:Cephalosporinase / Q000378:metabolism; D002569:Cerulenin / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D004925:Escherichia / Q000187:drug effects / Q000201:enzymology*; D007709:Klebsiella / Q000187:drug effects / Q000201:enzymology*; D011511:Proteus / Q000201:enzymology*; D011532:Providencia / Q000187:drug effects / Q000201:enzymology*
D000935:Antifungal Agents; D002569:Cerulenin; D002510:Cephalosporinase; D002509:Cephaloridine