An escape phenomenon from water and sodium retention induced by propranolol in rats.
Rats given a daily dose of propranolol 45 mg/kg b.wt retain water and sodium for 4 days, escaping during the 5th and 6th days in which their excretions are larger than basal values. Afterwards, in the period studied, they make a new retention and clearing is less accentuated. No relationship could be found between these retentions and plasma renin activity or renal renin content.
D000818:Animals; D001834:Body Water / Q000378:metabolism*; D004231:Diuresis / Q000187:drug effects*; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D012083:Renin / Q000378:metabolism; D012964:Sodium / Q000652:urine*; D013997:Time Factors
D012964:Sodium; D011433:Propranolol; D012083:Renin