Two Melanesian antisera reacting with SsU components.
Two different Melanesian antibodies demonstrated, by blocking tests and their reaction patterns, steric interaction of S, s and U components. The antigen(s) detected, designated Ux and Uz, may represent differing conformations, genetically determined, of certain U, S and s structures. Of 1,000 Caucasian bloods, 3 had very marked enhancement of Ux. Family studies are presented. In one such blood, abnormal steric interaction of D with s and U was indicated. Melanesian population studies show that Ux and Uz are among the antigens depressed in recessive ovalocytosis. The linkage disequilibria affecting MNSs and SsUz are inter-related, the associations being of SUz with Caucasian M and Melanesian N.
D044383:Black People; D001789:Blood Group Antigens; D004306:Dose-Response Relationship, Immunologic; D006801:Humans; D007106:Immune Sera; D007518:Isoantibodies / Q000032:analysis*; D007519:Isoantigens; D008542:Melanesia; D044465:White People
D001789:Blood Group Antigens; D007106:Immune Sera; D007518:Isoantibodies; D007519:Isoantigens