Variations in hepatic microsomal drug metabolism in C57Bl/6 mice from three different suppliers.
Drug metabolism by hepatic microsomal and soluble fractions was compared in male C57Bl/6 mice purchased from three different suppliers. Mice were studied at 9 weeks of age after having been purchased either as weanlings or at 8 weeks of age. Significant differences were found in the specific activity of several mixed-function oxidase enzymes and in amounts of cytochrome P-450 among the three sources of mice.
D000818:Animals; D001711:Biotransformation; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000235:genetics / Q000378:metabolism*; D008862:Microsomes, Liver / Q000378:metabolism*