[Effect of triterpene glycosides on the plasma membrane permeability for amino acids in Saccharomyces carlsbergensis yeast cells].
The effect of triterpen glycosides, such as cauloside C from Caulophyllum robustum, stichoposide A from Stichopus japonicus S and the asaponine from Thea sinensis L on permeability of the plasmic membranes for amino acids was studied. It was shown that the glycosides induced higher levels of liberation of the amino acids with positively or negatively charged molecules from the cells of Saccharomyces carlsbergensis as compared to the control. The transport of the non-polar amino acids was least affected by addition of the saponines to the incubation medium.
D000596:Amino Acids / Q000378:metabolism*; D001692:Biological Transport / Q000187:drug effects; D002463:Cell Membrane Permeability / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006027:Glycosides / Q000494:pharmacology*; D012440:Saccharomyces / Q000187:drug effects* / Q000378:metabolism; D013997:Time Factors; D014315:Triterpenes
D000596:Amino Acids; D006027:Glycosides; D014315:Triterpenes
Vliianie nekotorykh triterpenovykh glikozidov na pronitsaemost' plazmaticheskikh membran dlia aminokislot v drozhzhevykh kletakh Saccharomyces carlsbergensis.