Reversal of clofibrate-induced cholesterol oversaturation of bile with chenodeoxycholic acid.
Giving clofibrate 2 g daily to seven patients significantly increased the biliary cholesterol concentration while the proportion of bile acids fell. Five patients on established clofibrate treatment were given 750 mg of chenodeoxycholic acid (CDCA) daily for one month. Biliary lipid analysis after the CDCA treatment showed a significant fall in the proportion of cholesterol and a rise in that of bile acids. The serum lipid concentrations, which had already been reduced by diet and clofibrate, showed a further significant reduction after the introduction of CDCA. This study suggests that CDCA may be usefully combined with clofibrate to reverse the tendency towards cholesterol saturation of bile and enhance the effect of lowering serum lipid concentrations.
D000328:Adult; D001646:Bile / Q000032:analysis* / Q000187:drug effects; D001647:Bile Acids and Salts / Q000032:analysis; D002635:Chenodeoxycholic Acid / Q000494:pharmacology* / Q000627:therapeutic use; D002784:Cholesterol / Q000032:analysis*; D002994:Clofibrate / Q000494:pharmacology* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000188:drug therapy / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010743:Phospholipids / Q000032:analysis
D001647:Bile Acids and Salts; D010743:Phospholipids; D002635:Chenodeoxycholic Acid; D002784:Cholesterol; D002994:Clofibrate