5-S-cysteinyldopa excretion after treatment with 8-methoxypsoralen and UVA light.
The excretion of the specific melanocytic metabolite 5-S-cysteinyldopa was studied in patients with psoriasis treated by 8-methoxypsoralen and UVA light. A pronounced increase was found after only 2 days treatment, although no increase in pigmentation could yet be observed. Peak values for urinary 5-S-cysteinyldopa were noted after 1 or 2 weeks treatment. Increase in pigmentation persisted after the excretion maxima for 5-S-cysteinyldopa.
D000328:Adult; D003548:Cysteinyldopa / Q000652:urine*; D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D008297:Male; D008544:Melanocytes / Q000187:drug effects / Q000528:radiation effects; D008730:Methoxsalen / Q000627:therapeutic use*; D008875:Middle Aged; D010778:Photochemotherapy; D010858:Pigmentation; D011565:Psoriasis / Q000628:therapy* / Q000652:urine; D013997:Time Factors; D014467:Ultraviolet Therapy
D003548:Cysteinyldopa; D004295:Dihydroxyphenylalanine; D008730:Methoxsalen