Influence of some inhibitors of histamine metabolism on the gastric secretion.
Influence of some inhibitors of histamine metabolism on the gastric secretion. Acta Physiol. Pol., 1977, 28 (6): 515-520. The influence of inhibitors of histamine metabolism on histamine (H) and Nalpha Nalpha-dimethylhistamine (NDMH) stimulated gastric secretion was studied in guinea-pigs and cats. Inhibitors of monoamine oxidase (MAO) and diamine oxidase (DAO): N-oxide diacetylaminopyridine (AAP) and N-oxide 2 aminopyridine (AP) increased HCI secretion in the gastric juice after H and NDMH. Inhibitors of N-methyl transferase: amodiaquine (A) and quinacrine (Q) increased HC1 secretion in the gastric juice after H but not after NDMH. The lack of action of A and Q on NDMH-stimulated gastric secretion suggests, that in guinea-pig and cat NDMH is not methylated additionally at the imidazole ring and therefore, it is a stronger gastric secretagogue than histamine itself.
D000655:Amodiaquine; D000818:Animals; D002415:Cats; D004791:Enzyme Inhibitors; D005260:Female; D005750:Gastric Juice / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects*; D006168:Guinea Pigs; D006632:Histamine / Q000031:analogs & derivatives; D006633:Histamine Antagonists / Q000494:pharmacology*; D008297:Male; D008745:Methylation; D008780:Methyltransferases; D011796:Quinacrine
D004791:Enzyme Inhibitors; D006633:Histamine Antagonists; D000655:Amodiaquine; D006632:Histamine; D008780:Methyltransferases; D011796:Quinacrine