[Changes in liver metabolism following a standardized skin burn and intraperitoneal injection of a burn toxin isolated from burned mice skin. Studies on rat liver using isolation perfusion].
Parameters of liver metabolism were studied in the isolated perfused rat liver 5 days after a standard skin burn or an i.p. injection of a specific cutaneous burn toxin. Decreased values of the energy quotient ATP/ADP compared with normal controls were found. The absolute content of adenonucleotides was unchanged. The excretion of glucose and urea was also decreased in both groups and glucose synthesis after a lactate load was only slightly stimulated. The results show a direct influence of a burn toxin on hepatic metabolism suggesting a possible disturbance of oxydative phosphorylation.
D000227:Adenine Nucleotides / Q000378:metabolism*; D000818:Animals; D002056:Burns / Q000378:metabolism*; D005260:Female; D005947:Glucose / Q000096:biosynthesis / Q000378:metabolism; D007657:Ketone Bodies / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D051379:Mice; D051381:Rats; D014118:Toxins, Biological / Q000378:metabolism*; D014508:Urea / Q000378:metabolism
D000227:Adenine Nucleotides; D007657:Ketone Bodies; D014118:Toxins, Biological; D014508:Urea; D005947:Glucose
Leberstoffwechselveränderungen nach standardisierter Hautverbrennung und intraperitonealer Injektion eines aus verbrannter Mäusehaut isolierten Verbrennungstoxins. Versuche an der isoliert perfundierten Rattenleber.