Synthesis and local anesthetic activity of benzo[b]furan derivatives.
Several 2-dialkylaminoethyl 3-methyl-2-benzo[b]furancarboxylates, 2-dialkylaminoethyl 3-methyl-2-benzo[b]furancarbamates, and 3-methyl-2-benzo[b]furancarboxamide derivatives were prepared and tested for local anesthetic activity. Piperidinoethyl 3-methyl-2-benzo[b]furancarbamate, 2-diethylaminoethyl 3-methyl-2-benzo[b]-furancarboxylate, and N-(2-diethylaminoethyl)-3-methyl-2-benzo[b]-furancarboxamide were the most potent.
D000779:Anesthetics, Local / Q000138:chemical synthesis*; D000818:Animals; D001572:Benzofurans / Q000138:chemical synthesis* / Q000494:pharmacology; D051379:Mice; D011817:Rabbits
D000779:Anesthetics, Local; D001572:Benzofurans