Thryo-endocrine pathology, obstetric morbidity and schizophrenia: survey of a hundred families with a schizophrenic proband.
This preliminary communication reports that the mothers of 104 schizophrenic patients had: (1) a significantly higher incidence of thyroid disease than a carefully matched control group; (2) significantly more abortions, still-births and greater infant mortality. The findings and possible relevance of thyroid disease to schizophrenia are discussed. Three prospective studies currently in progress are outlined.
D000022:Abortion, Spontaneous / Q000235:genetics; D000328:Adult; D004200:Diseases in Twins; D005260:Female; D005313:Fetal Death / Q000235:genetics; D006801:Humans; D006980:Hyperthyroidism / Q000235:genetics; D007037:Hypothyroidism / Q000235:genetics; D009035:Mothers; D011247:Pregnancy; D011248:Pregnancy Complications / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*; D013959:Thyroid Diseases / Q000235:genetics*