Angioimmunoblastic lymphadenopathy. A generalized lymphoproliferative disorder with cutaneous manifestations.
Angioimmunoblastic lymphadenopathy (AIBL) is a recently described, systemic disorder characterized by an excessive proliferation of transformed lymphocytes, possibly the result of chronic antigenic stimulation, frequently by drugs. Cutaneous involvement, usually in the form of a pruritic, generalized, maculopapular rash, occurs in about 40% of cases. We saw a patient with AIBL who had an unusual, primarily plaque- and nodular-type of skin involvement and who had been receiving drugs not previously reported as being associated with this disorder. Because cutaneous involvement is a frequent, presenting complaint, dermatologists should be able to recognize this unusual, clinicopathologic entity.
D000368:Aged; D006801:Humans; D008206:Lymphatic Diseases / Q000139:chemically induced / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D012867:Skin / Q000473:pathology; D012877:Skin Manifestations