Low-dose cortisone for male infertility.
Thirty-eight males with idiopathic infertility were randomly treated with low-dose thyroid and low-dose cortisone. Pregnancy followed treatment with cortisone in 7 of 33 courses and followed treatment with thyroid in 4 of 30 courses (P = 0.5, not significant [NS]). The mean pretreatment count in all patients was 12.3 million/ml. The mean post-treatment count with thyroid was 11.2 million/ml as compared with 13 million/ml for cortisone treatment (P = 0.4, NS). Pretreatment motility was 45% as compared with 44% following thyroid treatment and 43% following cortisone treatment (P = 0.7, NS). The pregnancy rate seemed to correlate with pretreatment counts rather than with the type of treatment. The efficacy of low-dose cortisone for idiopathic fertility would seem to be in question.
D002452:Cell Count; D003348:Cortisone / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007248:Infertility, Male / Q000188:drug therapy*; D008297:Male; D011247:Pregnancy; D013081:Sperm Motility / Q000187:drug effects; D013094:Spermatozoa; D013963:Thyroid Hormones / Q000494:pharmacology / Q000627:therapeutic use
D013963:Thyroid Hormones; D003348:Cortisone