Portal hypertension in systemic mastocytosis.
We report the case of a 66-year-old male patient with portal hypertension related to systemic mastocytosis. The liver was enlarged; microscopic examination showed portal mast cell infiltration and fibrosis. Portal hypertension was evidenced by splenomegaly, esophageal varices, and increased wedged-free hepatic venous pressure gradient. Arteriography showed that portal vein was patent. Portal hypertension could be the consequence of intrahepatic block due to mast cell infiltration and/or fibrosis of the liver.
D000368:Aged; D001706:Biopsy; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications*; D008099:Liver / Q000473:pathology; D008297:Male; D008407:Mast Cells / Q000473:pathology; D011168:Portal System / Q000473:pathology; D014582:Urticaria Pigmentosa / Q000150:complications* / Q000473:pathology