Precocious 'feminization' of rat liver enzymes in the presence of ectopic pituitary tissue.
The presence of ectopic pituitary tissue (derived from an adult rat) in prepubertal male and female rats caused the immature, masculine-type hepatic steroid metabolism to develop into female-type metabolism. It is concluded that the hypothalamus-pituitary system controls the ontogenesis of sex-dependent steroid metabolism in rat liver.
D000375:Aging; D015113:Androstane-3,17-diol / Q000378:metabolism; D000735:Androstenedione / Q000378:metabolism; D000818:Animals; D005260:Female; D005262:Feminization / Q000378:metabolism; D008099:Liver / Q000201:enzymology* / Q000378:metabolism; D008297:Male; D010902:Pituitary Gland / Q000637:transplantation; D051381:Rats; D012727:Sex Characteristics; D014184:Transplantation, Homologous
D015113:Androstane-3,17-diol; D000735:Androstenedione