An attempt at passive transfer of immunity to leprosy patients by transfusion of allogeneic lymphocytes, inactivated with mitomycin C.
An attempt was made to repair cell-mediated immunity in 7 patients suffering from lepromatous leprosy and severe erythema nodosum leprosum by intravenous infusion of 400 million allogeneic blood lymphocytes on 3 occasions. The lymphocytes were obtained from lepromin and tuberculin-positive subjects and were inactivated in vitro by treatment with mitomycin C. Immunotherapy with inactivated lymphocytes only modified the severity of erythema nodosum leprosum, without altering other aspects of the disease.
D001803:Blood Transfusion; D004893:Erythema Nodosum / Q000276:immunology / Q000628:therapy*; D006801:Humans; D007111:Immunity, Cellular; D007116:Immunization, Passive; D007918:Leprosy / Q000276:immunology / Q000628:therapy*; D017710:Lymphocyte Transfusion; D008214:Lymphocytes / Q000187:drug effects; D008937:Mitomycins / Q000494:pharmacology
D008937:Mitomycins