Some effects of irradiation of mice in utero with tritiated compounds.
Mice have been exposed continuously, in utero, to tritiated water (via the maternal drinking water) or to tritiated thymidine (infused continuously into the mother). In both cases the patterns of labeling and subsequent loss of tritium over an extended period have been studied. The technique of infusion in unrestrained mice and its application in the production of fully tritium-labeled offspring is described in some detail. These fully labeled mice are being used to study a number of early and late effects, in particular, gonad cell effects and carcinogenesis, following this form of internal irradiation. Some preliminary results are presented. Similar results produced a homogeneous irradiation from tritiated water are also reported.
D000818:Animals; D002467:Cell Nucleus / Q000528:radiation effects; D002470:Cell Survival / Q000528:radiation effects; D004247:DNA / Q000378:metabolism; D004622:Embryo, Mammalian / Q000528:radiation effects*; D005260:Female; D008297:Male; D051379:Mice; D009865:Oocytes / Q000528:radiation effects; D011247:Pregnancy; D011835:Radiation Protection; D013936:Thymidine; D013997:Time Factors; D014018:Tissue Distribution; D014316:Tritium / Q000009:adverse effects* / Q000378:metabolism; D014867:Water
D014867:Water; D014316:Tritium; D004247:DNA; D013936:Thymidine