Chemical protection of mouse spermatocytes against gamma-rays with 2-mercaptopropionylglycine.
The radiosensitivity of primary spermatocytes in pachytene stage was estimated by counting the number of spermatids in the testes of control and MPG-treated mouse after exposure to 500, 1000 and 1500 R of Co60 gamma-rays. For this purpose, control and MPG-treated mice were killed 5 days after irradiation and countings of spermatids was made in stages I and II of the tubules. It has been observed that, although there was a death of primary spermatocytes in irradiated MPG-protected groups, quantitatively significant protection was afforded by this drug at all the 3 dose-levels studied.
D000603:Amino Acids, Sulfur / Q000494:pharmacology*; D000818:Animals; D005720:Gamma Rays; D008297:Male; D051379:Mice; D011837:Radiation-Protective Agents; D013087:Spermatids / Q000032:analysis; D013090:Spermatocytes / Q000528:radiation effects*; D013094:Spermatozoa / Q000528:radiation effects*; D013737:Testis / Q000166:cytology; D008625:Tiopronin / Q000008:administration & dosage / Q000494:pharmacology*
D000603:Amino Acids, Sulfur; D011837:Radiation-Protective Agents; D008625:Tiopronin