The mitigating effect of dietary antioxidants on chemically-induced carcinogenesis.
The effect of a dietary antioxidant mixture on 3-methylcholanthrene mediated carcinogenesis in hairless mice was investigated. The antioxidant mixture significantly reduced the frequency of premalignant lesions and their subsequent development into tumors. The similarities in response of chemical and UV light-carcinogenesis to these antioxidants suggest some congruity in the mechanisms of the carcinogenic process.
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D002273:Carcinogens / Q000037:antagonists & inhibitors*; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced; D003436:Croton Oil; D004032:Diet; D008748:Methylcholanthrene / Q000037:antagonists & inhibitors; D051379:Mice; D010212:Papilloma / Q000139:chemically induced; D011230:Precancerous Conditions / Q000139:chemically induced; D012878:Skin Neoplasms / Q000139:chemically induced*
D000975:Antioxidants; D002273:Carcinogens; D008748:Methylcholanthrene; D003436:Croton Oil