Stimulus properties of d-amphetamine as compared to l-amphetamine.
Rats were trained to discriminate between d-amphetamine and saline. The discriminable ED50 values for amphetamine isomers were calculated from dose--response curves and the potency ration was 4.9 Co-administration of the ED50s was shown to produce synergistic effects suggesting that the amphetamine isomers may share a common site of action.
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D003913:Dextroamphetamine / Q000494:pharmacology*; D004193:Discrimination Learning / Q000187:drug effects*; D004192:Discrimination, Psychological / Q000187:drug effects; D004347:Drug Interactions; D008297:Male; D051381:Rats; D013237:Stereoisomerism; D013268:Stimulation, Chemical
D000661:Amphetamine; D003913:Dextroamphetamine