Influence of aspirin on healing of chronic gastric ulcers in dogs.
Gastric ulcers induced in dogs by transserosal injection of 1 ml of 40% acetic acid healed completely by the 7th week after ulceration and never reulcerated during the observation period up to 12 weeks. Acetic acid ulcers in the active (at 1 week), quiescent (3 weeks) or healed (at 7 weeks) stages were not influenced by the daily administration of aspirin 2 g/dog/day for for 5 consecutive weeks. All examinations were done by gastroscopy in addition to macroscopical and histological observations at autopsy.
D000085:Acetates; D000818:Animals; D001241:Aspirin / Q000008:administration & dosage / Q000494:pharmacology*; D002908:Chronic Disease; D004285:Dogs; D005753:Gastric Mucosa / Q000473:pathology; D005773:Gastroscopy; D008297:Male; D010439:Peptic Ulcer Perforation / Q000473:pathology; D012008:Recurrence; D013276:Stomach Ulcer / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology*; D014945:Wound Healing / Q000187:drug effects
D000085:Acetates; D001241:Aspirin