Acetylenics. 2. Synthesis and pharmacology of certain N,N-diakyl-3-phenylpropyn-2-amines. Some analogues with tryptamine-like behavioral effects in mice.
A number of N,N-dialkyl-3-phenylpropyn-2-amines 7 have been prepared and tested for their biological action. Certain analogues show tryptamine-like behavior effects in mice. The tryptamine-like activity of these compounds appears to be controlled by their lipophilicity. These compounds show only weak inhibition of rat liver monoamine oxidase. Although these compounds exhibit tryptamine-like action, experiments seem to indicate that there is no interaction with the tryptamine receptors.
D000480:Alkynes / Q000138:chemical synthesis / Q000494:pharmacology*; D000588:Amines / Q000138:chemical synthesis / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008996:Monoamine Oxidase Inhibitors; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D011985:Receptors, Serotonin / Q000187:drug effects
D000480:Alkynes; D000588:Amines; D008996:Monoamine Oxidase Inhibitors; D011985:Receptors, Serotonin