Release of vasopressin by enkephalin.
Leu-enkephalin, its stable analogue [D-Ala2-D-Leu5]-enkephalin and the C-fragment of lipotropin (beta endorphin) injected intravenously in the rat produced antidiuretic responses which were inhibited reversibly by naloxone. It was shown for Leu-enkephalin that injection into the cerebral ventricles was at least ten times more effective than intravenous injection and for [D-Ala2-D-Leu5]-enkephalin that the antidiuretic response was associated with increased excretion of vaspressin in the urine.
D000818:Animals; D004723:Endorphins / Q000494:pharmacology*; D004745:Enkephalins / Q000494:pharmacology* / Q000652:urine; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D013997:Time Factors; D014667:Vasopressins / Q000378:metabolism*
D004723:Endorphins; D004745:Enkephalins; D014667:Vasopressins; D009270:Naloxone