[Effect of gnotobiotic conditions on the histophysiology of liver and spleen tissues].
The liver and spleen of gnotobiotic Wistar rats were examined by histochemical methods; the liver was also studied by electron microscopy. Under conditions of gnotobiotic animal existance the activity of succinic dehydrogenase, non-specific esterase in the liver was found to be decreased; fatty infiltration was intensified in the cytoplasm of hepatocytes and Kupffer's cells; a part of them is subject to fatty dystophy. At the same time both the activity of acid phosphatase of hepatocytes and the contents of lysosomes in the biliary poles of hepatocytes became increased. Decomposition of erythrocytes in the spleen, as well as release of free iron and pigments which stimulated excretion of bile in gnotobiotes were enhanced.
D000135:Acid Phosphatase / Q000502:physiology; D000367:Age Factors; D001654:Bile Pigments / Q000096:biosynthesis; D004789:Enzyme Activation; D004950:Esterases / Q000502:physiology; D005856:Germ-Free Life; D008099:Liver / Q000502:physiology* / Q000648:ultrastructure; D013154:Spleen / Q000502:physiology* / Q000648:ultrastructure; D013385:Succinate Dehydrogenase / Q000502:physiology
D001654:Bile Pigments; D013385:Succinate Dehydrogenase; D004950:Esterases; D000135:Acid Phosphatase
Vliianie gnotobioticheskikh usloviĭ na gistofiziologiiu tkaneĭ selezenki.