[Lysis of fresh experimental thrombi under the action of a secondary adrenaline-heparin-fibrinogen complex].
It is shown that the epinephrine-heparin-fibrinogen complex, as well as a number of other complex compounds of heparin accomplish the prophylaxis of thrombogenesis at the initial stages of the process, the epinephrine-heparin-fibrinogen complex lysing the thrombi in an average of 48 minutes, while the complexes of fibrinogen-heparin and epinephrine-heparin do this in 2--4 hours. The complex heparin compounds exercise a thrombolytic action only on non-stabilized fresh thrombi with less than 15 minutes from the time of their formation.
D000818:Animals; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D004837:Epinephrine / Q000627:therapeutic use*; D005340:Fibrinogen / Q000627:therapeutic use*; D005342:Fibrinolysis / Q000187:drug effects; D006493:Heparin / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D013927:Thrombosis / Q000188:drug therapy*; D013997:Time Factors
D004338:Drug Combinations; D005340:Fibrinogen; D006493:Heparin; D004837:Epinephrine
Lizis svezhikh éksperimental'nykh trombov pod deĭstviem vtorichnogo kompleksa adrenalin-geparin-fibrinogen.