[Effect of dichlothiazide on the transport of organic substances in the kidneys].
Following a protracted introduction of dichlothiazide to rats (20 mg/kg) and to dogs (5 mg/kg) there occurs a marked increase in the tubular secretion of the cardiotrast and passage of urates with urine. A single and long-term administration of the drug to dogs did not have any substantial effect on the maximal reabsorption of glucose.
D000042:Absorption; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D004231:Diuresis / Q000187:drug effects; D004285:Dogs; D005947:Glucose / Q000378:metabolism; D006852:Hydrochlorothiazide / Q000494:pharmacology*; D007468:Iodopyracet / Q000378:metabolism; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D007684:Kidney Tubules / Q000187:drug effects; D051381:Rats; D013997:Time Factors; D014527:Uric Acid / Q000378:metabolism
D006852:Hydrochlorothiazide; D014527:Uric Acid; D005947:Glucose; D007468:Iodopyracet
Vliianie dikhlotiazida na transport organicheskikh veshchestv v pochkakh.