Techniques for assessment of biliary excretion and enterohepatic circulation in the rat.
1. A surgical technique is described which enables biliary excretion studies to be performed in conscious unrestrained rats. 2. Bile is continuously collected in a glass vessel implanted into the peritoneal cavity. 3. Assessment of enterohepatic circulation is made by a modification of the technique. 4. The application of these techniques to both metabolic and pharmacokinetic studies is described briefly.
D000818:Animals; D001646:Bile / Q000378:metabolism*; D002404:Catheterization / Q000379:methods / Q000662:veterinary; D004764:Enterohepatic Circulation; D005260:Female; D008297:Male; D051381:Rats / Q000378:metabolism* / Q000601:surgery