Successful prevention of coumarin-induced hemorrhagic skin necrosis by timely administration of vitamin k1.
Successful prevention of the progression of incipient hemorrhagic skin necrosis by timely administration of vitamin K1 in a woman treated with phenprocoumon is presented. From a critical review of the literature strong evidence emerges that coumarin necrosis does only occur in cases with severe initial drug induced hypocoagulability. Non- recognition thusfar of its importance is due to insufficient knowledge of the biological activities of thromboplastin preparations presently used in the laboratory control of oral anticoagulation. All well documented cases with apparently adequate Quick values were monitored with Faktor VIII insensitive thromboplastin. Therefore, such preparations should no longer be used in anticoagulant control.
D015110:4-Hydroxycoumarins / Q000009:adverse effects*; D005260:Female; D006470:Hemorrhage / Q000139:chemically induced; D006801:Humans; D008875:Middle Aged; D009336:Necrosis; D010644:Phenprocoumon / Q000009:adverse effects*; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000139:chemically induced / Q000517:prevention & control*; D013925:Thromboplastin; D010837:Vitamin K 1 / Q000627:therapeutic use*
D015110:4-Hydroxycoumarins; D010837:Vitamin K 1; D013925:Thromboplastin; D010644:Phenprocoumon