Some effects of mianserin on monoamine metabolism in the rat brain.
1 Mianserin does not affect the uptake of biogenic amines into rat brain, in contrast to tricyclic antidepressants which block amine uptake. 2 Mianserin increases the turnover of noradrenaline (NA) in rat brain after acute or chronic administration, whereas tricyclic antidepressants reduce turnover of NA and 5-hydroxytryptamine. 3 It should not be assumed that a compound must inhibit amine re-uptake mechanisms before it can be considered as a potential antidepressant.
D000588:Amines / Q000378:metabolism*; D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D003984:Dibenzazepines / Q000494:pharmacology*; D008297:Male; D008803:Mianserin / Q000494:pharmacology*; D051381:Rats; D012701:Serotonin / Q000378:metabolism
D000588:Amines; D001679:Biogenic Amines; D003984:Dibenzazepines; D008803:Mianserin; D012701:Serotonin