[Antibody formation following immunization with mono- and bivalent mumps-(measles-)vaccine (author's transl)].
The authors studied the seroconversion of 307 children, 1-11 years old, induced by Mumpsvax (136 children) and a bivalent mumps-measles vaccine (strain Jeryl Lynn/strain Moraten; 171 vaccines) by the HI-test. The seroconversion induced by the measles component of the bivalent vaccine covered 96.3% of the seronegatives prior to immunization. The comparable values for mumps antibodies were lower (Mumpsvax:80.6%; bivlant vaccine: 82.2%). An increase in titer in seropositive children was obtained in 57.1% after immunization with Mumpsvax and in 50.8% with the bivalent vaccine. Comparative studies to investigate the sensitivity of the HI-test versus the neutralisation test (NT) showed the greater accuracy of the latter. Before the vaccination with Mumpsvax, only 26.6% of 60 sera studied were found to be seronegative, whilst the NT gave a more reliable figure (55%). Similar data were found in 62 sera before immunization with the bivalent vaccine (HI-test: 33.8%; NT:66.1% seronegative). The seroconversion rates were slightly higher when the NT had been used: 75.6% (bivalent) and 81.8% (monovalent vaccine) versus 75.6% and 75%, respectively, by the HI-test.
D000917:Antibody Formation; D002648:Child; D002675:Child, Preschool; D006386:Hemagglutination Tests; D006801:Humans; D007223:Infant; D008458:Measles Vaccine / Q000627:therapeutic use; D009108:Mumps Vaccine / Q000627:therapeutic use*; D009109:Mumps virus / Q000302:isolation & purification; D009500:Neutralization Tests
D008458:Measles Vaccine; D009108:Mumps Vaccine
Die Antikörperbildung nach Gabe von mono- und bivalenter Mumps-(Masern-)Vakzine.