Vitamins limiting for growth of subjects fed a normal diet under hyperbaric He-O2 conditions.
A growth study was conducted of rats continuously exposed for 4 weeks to ambient air, 1 ATA He-O2, or 11 ATA He-O2 conditions and fed one of 16 diets. The diets were the standard diet alone (adequate according to National Research Council standards); the standard diet with additional casein (50%), fat (25%), and all vitamins (25%); or the standard diet with all vitamins (25%), or all vitamins increased (25%) except one, which was supplied at the standard level. The standard diet was inadequate to support a normal rate of growth when fed under 11 ATA He-O2 conditions. Supplemental casein, fat, and vitamins or all vitamins alone adequately provided nutrients necessary for a normal rate of growth by hyperbaric exposed rats. The standard levels of thiamine, pantothenic acid, biotin, and vitamin K were inadequate and the standard levels of niacin, and vitamins A, D, and E were marginal in supporting growth when fed under hyperbaric conditions.
D000818:Animals; D001274:Atmospheric Pressure; D001835:Body Weight / Q000187:drug effects; D004032:Diet; D006128:Growth / Q000187:drug effects*; D006371:Helium; D008297:Male; D010100:Oxygen; D051381:Rats; D014815:Vitamins / Q000008:administration & dosage / Q000494:pharmacology*
D014815:Vitamins; D006371:Helium; D010100:Oxygen