Fetal metabolism during recovery from surgical stress.
10 fetal lambs prepared with sampling catheters in the common umbilical vein and distal aorta were studied at 2 h, 2 and 4 days postoperatively. Umbilical blood flow was measured by a diffusion equilibrium method. Oxygen, lactate, pyruvate, glucose and alpha-amino nitrogen concentrations were determined on umbilical arterial (UA) and umbilical vein (UV) blood. Fetal oxygen consumption averaged 10.4, 10.6 and 1.0 ml.kg-1.min-1 for the three study periods. Lactate/pyruvate ratios were higher in UV than in UA in 17 of 20 experiments. Significant reductions (p less than 0.05) in (1) maternal mixed venous-UA glucose concentration difference, and (2) UA glucose concentrations occurred at 2 and 4 days compared to the 2-hour period. Fetal alpha-amino nitrogen balance was negative at the 2-hour period, but positive 2 days and 4 days postoperatively.
D000818:Animals; D000830:Animals, Laboratory; D001011:Aorta / Q000601:surgery; D001786:Blood Glucose / Q000378:metabolism; D005260:Female; D005333:Fetus / Q000378:metabolism*; D007773:Lactates / Q000097:blood; D009584:Nitrogen / Q000097:blood; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption; D011247:Pregnancy; D011773:Pyruvates / Q000097:blood; D012756:Sheep / Q000502:physiology*; D013312:Stress, Physiological; D013514:Surgical Procedures, Operative; D014470:Umbilical Cord / Q000098:blood supply; D014471:Umbilical Veins / Q000601:surgery
D001786:Blood Glucose; D007773:Lactates; D011773:Pyruvates; D009584:Nitrogen; D010100:Oxygen