Reversal of guanethidine blockade of sympathetic nerve terminals by tetraethylammonium and 4-aminopyridine.
1 The effect of tetraethylammonium (TEA) and 4-aminopyridine (4-AP) on the inhibitory effect of guanethidine on noradrenaline (NA) release was investigated in the perfused spleen of the cat. 2 Guanethidine blocked the release of NA evoked by nerve stimulation. TEA and 4-AP readily reversed this inhibitory effect, and the NA output was nearly doubled after repeated stimulation of the nerves. On subsequent perfusion with Krebs solution without TEA or 4-AP, the inhibitory effect of guanethidine reappeared. 3 The reversal of guanethidine blockade of sympathetic nerves by TEA and 4-AP is discussed.
D000818:Animals; D002415:Cats; D004558:Electric Stimulation; D006145:Guanethidine / Q000037:antagonists & inhibitors*; D009411:Nerve Endings / Q000187:drug effects*; D009638:Norepinephrine / Q000378:metabolism; D011725:Pyridines / Q000494:pharmacology*; D013154:Spleen / Q000294:innervation / Q000378:metabolism; D013564:Sympathetic Nervous System / Q000187:drug effects*; D013757:Tetraethylammonium Compounds / Q000494:pharmacology*
D011725:Pyridines; D013757:Tetraethylammonium Compounds; D009638:Norepinephrine; D006145:Guanethidine