[Experimental hyperammoniemia].
The effect of chloralose anesthesia and of hypoxia or hypercapnia of altogether 40 minutes' duration on the concentrations of ammonia in the arterial blood was investigated in mongrel dogs. The NH3 values increased marginally as a result of chloralose anesthesia and only slightly as a result of severe (Pao2=32 mm Hg), acute hypoxia. Hypercapnia (Paco2=75 or 111 mm Hg) induced with a mixture of gases was accompanied by an increase of commensurate degree in the blood ammonia levels which was presumably attributable to an augmented protal-to-systemic shunt circulation.
D000641:Ammonia / Q000097:blood*; D000818:Animals; D001639:Bicarbonates / Q000097:blood; D002698:Chloralose / Q000494:pharmacology; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate; D006935:Hypercapnia / Q000150:complications; D000860:Hypoxia / Q000150:complications
D001639:Bicarbonates; D002698:Chloralose; D000641:Ammonia
Experimentelle hyperammoniämie.