A genetic study of immunoglobulin E.
Path analysis gives evidence of genetic heritability (.425) for serum IgE levels. Complex segregation analysis indicates, in addition to significant polygenic heritability, a major regulatory locus RE, with homozygotes re/re maintaining persistently high levels of IgE. The gene frequency of re is .489, and the displacement is 1.67 standard deviations.
D005260:Female; D005787:Gene Frequency; D005796:Genes; D006801:Humans; D006967:Hypersensitivity / Q000235:genetics*; D007073:Immunoglobulin E / Q000235:genetics*; D008297:Male; D013223:Statistics as Topic
D007073:Immunoglobulin E