In vitro steroid metabolic studies in human testes. II: Metabolism of cholesterol, pregnenolone, progesterone, androstenedione and testosterone by testes of an estrogen-treated man.
The effect of long-term in vivo estrogen treatment on in vitro steroidogenesis by the testes of a young man was investigated. In vitro incubation of testicular tissue of this man with 3H-pregnenolone, 3H-progesterone, 3H-androstenedione and 3H-testosterone demonstrated suppression of 17-hydroxylase activity, with little or no effect of the treatment on delta5-3beta-hydroxysteroid oxidoreductase, 5alpha-reductase and aromatase. Increased 20alpha-hydroxysteroid oxidoreductase activity was observed. Determination of intratesticular steroid concentrations led to similar conclusions.
D000328:Adult; D000728:Androgens / Q000378:metabolism*; D000735:Androstenedione / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism*; D045166:Estradiol Congeners / Q000494:pharmacology*; D004967:Estrogens / Q000502:physiology; D004997:Ethinyl Estradiol / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008297:Male; D011284:Pregnenolone / Q000378:metabolism; D011374:Progesterone / Q000378:metabolism; D011372:Progestins / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000378:metabolism; D013737:Testis / Q000187:drug effects / Q000378:metabolism*; D013739:Testosterone / Q000378:metabolism; D014189:Transsexualism / Q000188:drug therapy / Q000378:metabolism
D000728:Androgens; D045166:Estradiol Congeners; D004967:Estrogens; D011372:Progestins; D013739:Testosterone; D000735:Androstenedione; D004997:Ethinyl Estradiol; D011374:Progesterone; D011284:Pregnenolone; D002784:Cholesterol