Hypokinesia produced by anterolateral hypothalamic 6-hydroxydopamine lesions and its reversal by some antiparkinson drugs.
Hypokinesia produced by stereotaxic microinjection of solutions of 6-hydroxydopamine into the anterolateral hypothalamus of male rats is accompanied by a generalized reduction in brain noradrenaline levels and a reduction of dopamine in the striatum and cerebral cortex. The hypokinesia is reversed by the putative dopamine-receptor agonists apomorphine, ET-495 and CB-154 as well as by the amino acids L-Dopa and m-tyrosine when administered in combination with the peripheral decarboxylase inhibitor Ro 4-4602. The relative importance of noradrenergic and dopaminergic systems in the mediation of the action of anti-akinesia drugs is discussed.
D000818:Animals; D000978:Antiparkinson Agents / Q000494:pharmacology*; D001058:Apomorphine / Q000494:pharmacology; D001921:Brain / Q000378:metabolism; D001971:Bromocriptine / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism; D006892:Hydroxydopamines / Q000009:adverse effects*; D007031:Hypothalamus / Q000502:physiology*; D007032:Hypothalamus, Anterior / Q000187:drug effects / Q000502:physiology*; D007980:Levodopa / Q000494:pharmacology; D008297:Male; D008959:Models, Neurological; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology*; D009638:Norepinephrine / Q000378:metabolism; D010891:Piribedil / Q000494:pharmacology; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects; D012701:Serotonin / Q000378:metabolism; D014443:Tyrosine / Q000494:pharmacology
D000978:Antiparkinson Agents; D006892:Hydroxydopamines; D011954:Receptors, Dopamine; D012701:Serotonin; D001971:Bromocriptine; D014443:Tyrosine; D007980:Levodopa; D010891:Piribedil; D001058:Apomorphine; D004298:Dopamine; D009638:Norepinephrine