In acute pancreatitis the decrease of villous activity, the damage of the intestinal mucosa might be induced by agents produced during pancreatitis or by trypsin.
If injected into the blood circulation, pancreatitic abdominal exudate significantly reduces villous activity and blood pressure. A relationship can be established between the log of the exudate doses and their effects.
D000818:Animals; D001794:Blood Pressure; D004285:Dogs; D005122:Exudates and Transudates; D006470:Hemorrhage / Q000139:chemically induced / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000187:drug effects / Q000503:physiopathology*; D010195:Pancreatitis / Q000139:chemically induced / Q000378:metabolism*; D051381:Rats; D014357:Trypsin / Q000494:pharmacology
D014357:Trypsin