Plasma vasopressin concentrations and effects of vasopressin antiserum on blood pressure in rats with malignant two-kidney Goldblatt hypertension.
Male Sprague-Dawley rats with unilateral renal artery stenosis and a contralateral untouched kidney develop a malignant hypertension (MH) which is characterized by high blood pressures, sodium and water depletion, and subsequent activation of the renin-angiotensin system. In the present studies we found plasma arginine vasopressin (AVP) concentrations-3-fold higher than those in rats with benign renal hypertension, and 4- to 5-fold higher than those in normotensive control rats. Analysis of individual values showed considerable scatter; about 50% of the values fell in the range of benign hypertensive or control rats. When a specific AVP antiserum was injected, iv, into eight conscious unrestrained MH rats, BP transiently fell toward control values in four; in one, BP fell by only 10 mm Hg, and three other MH rats showed no response. In the same rats, injection of a specific angiotensin II antiserum always induced a transient fall in BP. On the basis of these and previously reported observations, we conclude that, subsequent to sodium and water loss and activation of the renin-angiotensin system, vasopressin release is stimulated in a significant number of MH rats and that, in these rats, vasopressin may cause significant systemic vasoconstriction. Thereby vasopressin may contribute to the development of malignant renal hypertension in rats.
D000818:Animals; D001127:Arginine Vasopressin / Q000097:blood; D001794:Blood Pressure; D006974:Hypertension, Malignant / Q000503:physiopathology*; D006977:Hypertension, Renal / Q000503:physiopathology*; D007106:Immune Sera / Q000494:pharmacology*; D008297:Male; D009318:Natriuresis; D051381:Rats; D012078:Renal Artery Obstruction / Q000503:physiopathology; D012964:Sodium / Q000378:metabolism; D014661:Vasoconstriction / Q000187:drug effects; D014667:Vasopressins / Q000097:blood* / Q000276:immunology / Q000502:physiology; D014882:Water-Electrolyte Balance
D007106:Immune Sera; D014667:Vasopressins; D001127:Arginine Vasopressin; D012964:Sodium