[Chronic granulomatosis in childhood].
In a boy aged 8 years suffering from chronic granulomatosis of childhood necrotizing pneumonie and small pulmonary tuberculoid granulomas containing filaments of moulds were found at autopsy. Necrotizing leucocytic granulomas were present in the liver, spleen and the lymph nodes. All the organs showed aggregates of histiocytes containing yellowish cytoplasmic deposits of lipogment surrounded by a high acid phosphatase activity. The NBT-reduction leucocytic tests was repeatedly negative in vivo. The activities of NADH- and NADPH-tetrazolium reductase and succinate dehydrogenase in the tissues were histochemically normal.
D000367:Age Factors; D001344:Autopsy; D002648:Child; D002675:Child, Preschool; D005500:Follow-Up Studies; D006105:Granulomatous Disease, Chronic / Q000473:pathology*; D006801:Humans; D008099:Liver / Q000473:pathology; D008168:Lung / Q000473:pathology; D008297:Male
Chronická granulomatóza dĕtskéhovĕku.