Effect of various inhibitors on the multiplication of BLE bacteriophage in Bacillus licheniformis.
A total of 40 substances were tested for their inhibitory effect on the multiplication of a bacteriophage in a growing culture of Bacillus licheniformis and their influence on bacitracin production. Acriflavine was the only substance which, at a concentration of 3 microgram ml-1, completely suppressed phage multiplication while having no effect on the growth of Bacillus licheniformis and on the production of the antibiotic.
D000167:Acriflavine / Q000494:pharmacology; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001407:Bacillus / Q000378:metabolism; D001414:Bacitracin / Q000096:biosynthesis; D001435:Bacteriophages / Q000187:drug effects* / Q000254:growth & development; D014779:Virus Replication / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D001414:Bacitracin; D000167:Acriflavine