Inhibition by isoptin (a calcium antagonist) of the mitogenic stimulation of lymphocytes prior to the S-phase.
Isoptin (alpha-isopropyl-alpha-(N-methyl-N-homoveratryl)-gamma-amino-propyl-3,4-dimethoxyphenylacetonitril-hydrochloride)--a calcium antagonist--inhibits mitogenic stimulation of lymphocytes. Isoptin acts prior to the S-phase of the cehl cycle but does not prevent the early events involved in triggering of cell mitosis. The drug seems to be a good tool for studying the relevance of the 'early events' assumed to be involved in lymphocyte stimulation.
D000818:Animals; D002453:Cell Cycle; D005260:Female; D008213:Lymphocyte Activation / Q000187:drug effects*; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008934:Mitogens / Q000494:pharmacology; D013154:Spleen / Q000166:cytology; D014700:Verapamil / Q000494:pharmacology*
D008934:Mitogens; D014700:Verapamil