[Effect of chlorpromazine on the relation between temperature and the binding of ANS by human erythrocytes].
It has been shown that under the effect of chlorpromazin (concentration to 2.10(-5) M) breaks observed on Arrhenius graphs of the rate constant of ANS binding with erythrocytes (k) at 28 and 36 degrees C are shifted to the region of low temperatures approximately to a similar interval (14-15 degrees C). The value k measured at 22 degrees C is not changed within the pH range of 5-7. It is concluded that breaks characterised the initial and final stages of temperature transition initiated in the zone of acid phospholipid of membranes.
D000817:Anilino Naphthalenesulfonates / Q000378:metabolism*; D002746:Chlorpromazine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D013696:Temperature
D000817:Anilino Naphthalenesulfonates; D002746:Chlorpromazine
Vliianie khlorpromazina na temperaturnuiu zavisimost' sviazyvaniia ANS s éritrotsitami cheloveka.