Interaction of the anti-tumour drug cis-Pt(en)Cl2 with Cytidilyl-3'--5'-guanosine.
Chemical shifts occurring in 1H nuclear magnetic resonance and Sephadex G 25 chromatography are used to follow the reaction of the dinucleotide C3'p5'G (cytidilyl-3'phosphate5'-guanosine) in aqueous solution and to separate its products. Binding of the platinum occurs in first place at the cytosine, then at the guanine base. Two major complexes are produced, Pt:CpG and (Pt:CpG)2, which account for respectively for an internal and an external cross-linking effect.
D000970:Antineoplastic Agents; D003568:Cytidine Monophosphate; D003597:Cytosine Nucleotides; D006151:Guanosine; D009682:Magnetic Resonance Spectroscopy; D010984:Platinum
D000970:Antineoplastic Agents; D003597:Cytosine Nucleotides; D006151:Guanosine; D010984:Platinum; D003568:Cytidine Monophosphate