Induction of avidin in the chick oviduct by tissue damage and prostaglandins.
In immature, diethylstilboestrol-treated chicks, ligation of the oviduct caused local avidin synthesis in the immediate vicinity of the ligature. PGF-2alpha injected directly into the oviduct also induced avidin synthesis, whereas saline or PGE-2 had no effect. PGE and PGF-2alpha concentrations increased in the oviduct within 24 h of ligation: the PGE increase could be partly inhibited by indomethacin, whereas that of PGF-2alpha was less inhibited. An LD50 dose of indomethacin alone and with ligation had a clear stimulatory effect on avidin synthesis, whereas aspirin alone, or with ligation, was not effective. Ligation alone and with indomethacin appeared to alter the PGF-2alpha/PGE ratio. These results suggest that PGF-2alpha may be involved in the regulation of avidin synthesis in the chick oviduct.
D000818:Animals; D001360:Avidin / Q000096:biosynthesis*; D002645:Chickens; D005260:Female; D007213:Indomethacin / Q000494:pharmacology; D010047:Ovalbumin / Q000031:analogs & derivatives*; D010057:Oviducts / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D011458:Prostaglandins E / Q000096:biosynthesis / Q000494:pharmacology; D011460:Prostaglandins F / Q000096:biosynthesis / Q000494:pharmacology*
D011458:Prostaglandins E; D011460:Prostaglandins F; D001360:Avidin; D010047:Ovalbumin; D007213:Indomethacin