[Biosynthesis of C19- and C21-steroids in tissue slices of paraganglioma and pheochromocytoma (author's transl)].
The biogenesis of C19- and C21-steroids has been studied in tissue slices of a paraganglioma, of a pheochromocytoma and of human adrenal cortex using radioactive steroids. Slices of paraganglioma as well as of pheochromocytoma metabolise 17-hydroxyprogesterone to cortisone, cortisol, 11-deoxycortisol and testosterone. The rate of formation of these steroids, however, by the two tumours is 8--15 times less than that in normal adrenal cortex tissue. After incubation of dehydroepiandrosterone with tissue slices of paraganglioma and pheochromocytoma, 7alpha-hydroxydehydroepiandrosterone, 11beta-hydroxy-4-androstene-3,17-dione and 4-androstene-3,17-dione were found as metabolites; testosterone was converted by both tissues to 4-androstene-3,17-dione. 17-Hydroxypregnenolone was converted to a small extent (1.7%) to dehydroepiandrosterone by slices of paranganglioma. These results show that enzymes of steroid biosynthesis (hydroxylases, oxidoreductases, delta4(-5)-isomerases, C17(-20)-desmolases) are present in both paraganglioma and pheochromocytoma.
D000302:Adrenal Cortex / Q000378:metabolism; D006801:Humans; D007535:Isomerases / Q000378:metabolism; D008190:Lyases / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000378:metabolism; D010088:Oxidoreductases / Q000378:metabolism; D010235:Paraganglioma / Q000201:enzymology / Q000378:metabolism*; D010673:Pheochromocytoma / Q000201:enzymology / Q000378:metabolism*; D013256:Steroids / Q000096:biosynthesis*
D013256:Steroids; D006899:Mixed Function Oxygenases; D010088:Oxidoreductases; D008190:Lyases; D007535:Isomerases
Biosynthese von C19- und C21-Steroiden im Paragangliom und Phäochromozytom des Menschen.