Rabies viruses increase in virulence when propagated in neuroblastoma cell culture.
Several strains of attenuated rabies virus lacking the capacity to kill adult mice acquired a high lethal potential for mice after one to five serial passages in murine or human neuroblastoma cells. The virulence acquired after passage in neuroblastoma cells is a stable genetic trait retained during subsequent passage of viruses in nonneuroblastoma cell systems.
D000818:Animals; D002460:Cell Line; D002478:Cells, Cultured; D051379:Mice; D009447:Neuroblastoma / Q000382:microbiology*; D009474:Neurons / Q000382:microbiology; D011819:Rabies Vaccines / Q000633:toxicity; D011820:Rabies virus / Q000235:genetics / Q000472:pathogenicity*; D014613:Vaccines, Attenuated / Q000633:toxicity; D014779:Virus Replication
D011819:Rabies Vaccines; D014613:Vaccines, Attenuated