[GABA system as a factor facilitating the development of compensation of disordered cerebral hemodynamics].
Shifts in the system of GABA transformation in ischemia and specific inhibition of GABA-transaminase under conditions of quantitative measurement of the blood circulation by means of hydrogen clearance permitted to establish a definite association between the increased GABA level in the brain and the tissues of the wall of its arteries, and the development of compensation of disturbed cerebral circulation. Consequently, one of the principal manifestations of an increased amount of endogenous GABA in deficiency of the brain blood supply was GABA capacity to improve the cerebral circulation.
D000222:Adaptation, Physiological; D000613:Aminobutyrates / Q000502:physiology*; D000818:Animals; D001921:Brain / Q000098:blood supply; D002415:Cats; D002561:Cerebrovascular Disorders / Q000378:metabolism / Q000503:physiopathology*; D004285:Dogs; D005968:Glutamate Decarboxylase / Q000378:metabolism; D006439:Hemodynamics; D051381:Rats; D013997:Time Factors; D000637:Transaminases / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism / Q000502:physiology*
D000613:Aminobutyrates; D005680:gamma-Aminobutyric Acid; D000637:Transaminases; D005968:Glutamate Decarboxylase
Sistema GAMK kak faktor, sposobstvuiushchiĭ vozniknoveniiu kompensatsii narushennoĭ mozgovoĭ gemodinamiki.