Comparative antiphlogistic activity of meseclazone, 5-chlorosalicylic acid, acetylsalicylic acid, phenylbutazone, indomethacin and hydrocortisone in various rat paw edema models.
The antiphlogistic activity of meseclazone and its major metabolite, 5-chlorosalicylic acid, have been directly compared to acetylsalicylic acid, phenylbutazone, indomethacin and hydrocortisone in rat paw edema induced by eleven different phlogistic agents. Based on the profile of activity and milligram/kilogram potency displayed by meseclazone, it most closely resembles acetylsalicylic acid and phenylbutazone in its mode of action.
D000818:Animals; D000893:Anti-Inflammatory Agents; D001241:Aspirin / Q000627:therapeutic use; D048588:Benzoxazines; D004353:Drug Evaluation, Preclinical; D004487:Edema / Q000188:drug therapy; D006854:Hydrocortisone / Q000627:therapeutic use; D007213:Indomethacin / Q000627:therapeutic use; D007555:Isoxazoles / Q000627:therapeutic use; D008297:Male; D010078:Oxazines / Q000627:therapeutic use; D010653:Phenylbutazone / Q000627:therapeutic use; D051381:Rats; D012459:Salicylates / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D048588:Benzoxazines; D007555:Isoxazoles; D010078:Oxazines; D012459:Salicylates; C006165:meseclazone; D010653:Phenylbutazone; C015751:5-chlorosalicylic acid; D001241:Aspirin; D006854:Hydrocortisone; D007213:Indomethacin