Influence of carbon tetrachloride on induction of tumours of the liver and kidneys in mice by netrosamines.
Mice were given a single dose of nitrosolimethylamine, nitrosoliethylamine or nitrosomethylethylamine and the yield of tumours and related lesions in the livers determined 12 months later. A hepatonecrotic dose of CCl4 24 or 48 h before the nitrosamines, increased the yields of hepatocellular tumours and proliferative foci in the livers, whereas when given 60 h before the nitrosamines there was no significant effect.
D000818:Animals; D002251:Carbon Tetrachloride / Q000494:pharmacology*; D004357:Drug Synergism; D007668:Kidney / Q000473:pathology; D007680:Kidney Neoplasms / Q000139:chemically induced*; D007928:Lethal Dose 50; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000139:chemically induced*; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009602:Nitrosamines / Q000633:toxicity*; D011230:Precancerous Conditions; D013997:Time Factors
D009602:Nitrosamines; D002251:Carbon Tetrachloride