Piperidylalkylindoles. 1. Hypotensive activity of 3-[2-(phenoxypiperidyl)ethyl]indoles.
A series of 3-[2-(phenoxypiperidyl)-ethyl]indoles was synthesized and evaluated for hypotensive activity in the spontaneous hypertensive rat. Maximum hypotensive activity appeared when the phenoxy substituent was para substituted and occupied the 4 position of the piperidine ring.
D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis; D004353:Drug Evaluation, Preclinical; D006973:Hypertension / Q000188:drug therapy*; D007211:Indoles / Q000138:chemical synthesis / Q000627:therapeutic use*; D010880:Piperidines / Q000138:chemical synthesis / Q000627:therapeutic use*; D051381:Rats
D000959:Antihypertensive Agents; D007211:Indoles; D010880:Piperidines