Constitutional factors and the local and general responses to injury.
The different constitutional factors which may affect the response to injury and the problems which must be considered in evaluating any injury model are discussed. Species, age, sex, nutrition and the presence of disease are discussed in relation to an injury model based on hind limb ischaemia, with reference to the extensive literature.
D000375:Aging; D000818:Animals; D001824:Body Constitution; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology; D006614:Hindlimb / Q000098:blood supply; D007511:Ischemia / Q000503:physiopathology; D009748:Nutrition Disorders / Q000503:physiopathology; D011817:Rabbits; D051381:Rats; D012008:Recurrence; D012737:Sex Factors; D013045:Species Specificity; D014949:Wounds, Nonpenetrating / Q000503:physiopathology*