Inhibition of maturation of Rauscher leukemia virus by amino acid analogs.
Synthesis of primary precursor polyproteins of Rauscher leukemia virus (RLV) core and envelope proteins occurs in the presence of amino acid analogs canavanine and p-fluorophenylalanine, but cleavage of these precursors is severely inhibited or slowed down. After treatment with these agents, the release of characteristic virus or stable virus-like particles is greatly depressed.
D002172:Canavanine / Q000494:pharmacology*; D046508:Culture Techniques; D010452:Peptide Biosynthesis; D010649:Phenylalanine / Q000031:analogs & derivatives*; D011498:Protein Precursors / Q000096:biosynthesis / Q000378:metabolism*; D011925:Rauscher Virus / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D014764:Viral Proteins / Q000096:biosynthesis / Q000378:metabolism*; D014779:Virus Replication / Q000187:drug effects; D010135:p-Fluorophenylalanine / Q000494:pharmacology*
D011498:Protein Precursors; D014764:Viral Proteins; D002172:Canavanine; D010649:Phenylalanine; D010135:p-Fluorophenylalanine