Pharmacological evidence for the involvement of Na+ channels in the release of catecholamines from perfused adrenal glands.
Veratridine (0.1 mM) was found to be effective in producing an increase in the catecholamine output from perfused guinea-pig adrenal glands in the presence of high concentrations of hexamethonium (1.83 mM) and atropine (28.8 micrometer). The response to veratridine was abolished by removal of either Na+ or Ca2+ from perfusion media and by the addition of tetrodotoxin (0.1 micrometer). It is suggested that the response to veratridine may be due to an increase in the tetrodotoxin-sensitive Na+ permeability of chromaffin cell membranes.
D000311:Adrenal Glands / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002118:Calcium / Q000502:physiology; D002395:Catecholamines / Q000378:metabolism*; D006168:Guinea Pigs; D006584:Hexamethonium Compounds / Q000494:pharmacology; D066298:In Vitro Techniques; D008566:Membranes / Q000378:metabolism; D012964:Sodium / Q000502:physiology*; D013779:Tetrodotoxin / Q000494:pharmacology; D013997:Time Factors; D014701:Veratridine / Q000494:pharmacology
D002395:Catecholamines; D006584:Hexamethonium Compounds; D013779:Tetrodotoxin; D014701:Veratridine; D001285:Atropine; D012964:Sodium; D002118:Calcium