Effect of lithium on hypothalamic-pituitary dopaminergic function.
The effect of lithium on apomorphine-induced growth hormone secretion and haloperidol-induced prolactin secretion was examined in eight male subjects without history of manic-depressive illness. Lithium had no effect on baseline or drug-induced changes in serum growth hormone or prolactin concentrations. These data suggest that lithium does not alter hypothalamic-pituitary dopamine receptor function.
D000328:Adult; D001058:Apomorphine / Q000494:pharmacology; D013006:Growth Hormone / Q000378:metabolism*; D006220:Haloperidol / Q000494:pharmacology; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects*; D008094:Lithium / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D011388:Prolactin / Q000378:metabolism*; D011954:Receptors, Dopamine / Q000187:drug effects*
D011954:Receptors, Dopamine; D011388:Prolactin; D013006:Growth Hormone; D008094:Lithium; D006220:Haloperidol; D001058:Apomorphine