Estrogen excretion patterns in induced ovulation.
Observation of response to gonadotropins in the treatment of anovulation has allowed us to define the estrogen excretion pattern which leads to a successful single pregnancy. The typical pattern shows a low pretreatment urinary total estrogen excretion; treatment with gonadotropins, of human pituitary origin, is continued for about 14 days. There is a predictable rate of rise of preovulatory estrogen excretion (30 microgram/24 hr2). Human choronic gonadotropin--about 4000 IU--should be given when an estrogen excretion of 75-100 microgram/24 hr has been obtained. The use of this pattern of ovarian response is put forward as a useful guide in the planning of gonadotropin therapy.
D000858:Anovulation / Q000188:drug therapy*; D004967:Estrogens / Q000652:urine*; D005260:Female; D006065:Gonadotropins, Pituitary / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D008183:Luteal Phase; D010062:Ovulation Induction; D011247:Pregnancy; D013997:Time Factors
D004967:Estrogens; D006065:Gonadotropins, Pituitary