A comparison of drug-metabolizing capability in isolated viable rat hepatocytes and renal tubule fragments.
1. The metabolism of a number of xenobiotics has been investigated in isolated viable rat hepatocytes and kidney tubule fragments in suspension. 2. The level of Phase I metabolism was very low in the kidney cells although such cells possess appreciable Phase II metabolic capacity. 3. These findings are discussed in relation to the physiological role of cytochrome P-450 and the conjugating enzymes, and the value of intact cells systems in assessing inter-organ differences in xenobiotic metabolism.
D000818:Animals; D001565:Benzoates / Q000378:metabolism; D001580:Benzopyrenes / Q000378:metabolism; D001713:Biphenyl Compounds / Q000378:metabolism; D003374:Coumarins / Q000378:metabolism; D006923:Hymecromone / Q000378:metabolism; D066298:In Vitro Techniques; D007684:Kidney Tubules / Q000378:metabolism*; D008099:Liver / Q000166:cytology / Q000378:metabolism*; D008297:Male; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D051381:Rats
D001565:Benzoates; D001580:Benzopyrenes; D001713:Biphenyl Compounds; D003374:Coumarins; D004364:Pharmaceutical Preparations; D006923:Hymecromone