Epidermal antihyperplastic effects of contact antiphlogistics.
The inhibitory effects of six contact antiphlogistics and two dermatocorticoids on hexadecane-induced hyperplasia of the guinea-pig skin were tested and compared. On the basis of the results obtained, the substances can be ranked in the following order of potency (percent inhibition of surface epithelial proliferation): acetylsalicylic acid (7.9%), phenylbutazone (12.5%), bufexamac (16.4%), bendazac (16.6%), oxyphenbutazone (19.5%), indomethacin (20.0%), hydrocortisone (20.6%) and fluocinolone acetonide (32.0%).
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology; D002019:Bufexamac / Q000494:pharmacology; D005446:Fluocinolone Acetonide / Q000494:pharmacology; D006168:Guinea Pigs; D006854:Hydrocortisone / Q000494:pharmacology; D006965:Hyperplasia; D007191:Indazoles / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D010113:Oxyphenbutazone / Q000494:pharmacology; D010168:Palmitates / Q000008:administration & dosage; D010653:Phenylbutazone / Q000494:pharmacology; D012867:Skin / Q000187:drug effects* / Q000473:pathology
D000893:Anti-Inflammatory Agents; D007191:Indazoles; D010168:Palmitates; D005446:Fluocinolone Acetonide; D002019:Bufexamac; D010653:Phenylbutazone; D010113:Oxyphenbutazone; D001241:Aspirin; D006854:Hydrocortisone; D007213:Indomethacin