Mesenchymal tumor hypoglycemia: the effect of a tumor tissue extract on the insulin and glucagon secretion from the isolated perfused porcine pancreas.
Severe fasting hypoglycemia and hypoinsulinemia occurred in a sixty-six year old woman with an intrahepatic mesenchymal tumor. An extract from the tumor was potent in inhibiting the arginine-induced glucagon secretion from the isolated perfused porcine pancreas. This observation supports the theory recently advanced that mesenchymal tumor hypoglycemia in some cases is due to a still unknown factor secreted from the tumor, which directly inhibits pancreatic glucagon secretion.
D000368:Aged; D000818:Animals; D001120:Arginine / Q000037:antagonists & inhibitors; D005260:Female; D005934:Glucagon / Q000378:metabolism; D006801:Humans; D007003:Hypoglycemia / Q000209:etiology*; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D008637:Mesenchymoma / Q000032:analysis* / Q000150:complications; D010179:Pancreas / Q000187:drug effects*; D010190:Pancreatic Neoplasms / Q000032:analysis* / Q000150:complications; D013552:Swine; D014020:Tissue Extracts / Q000494:pharmacology*
D007328:Insulin; D014020:Tissue Extracts; D005934:Glucagon; D001120:Arginine