[Transmural electronic potential difference--a functional parameter of the gastric mucosal barrier (author's transl)].
The transmural electric potential difference represents the resultant of a complex of electromotive forces across the gastric mucosal barrier. Its quantitative changes correlate with other functional parameters of the gastric mucosal barrier: H+-back diffusion, Na+-influx, ultrastructural changes of the mucosa. Measurement of the transmural electric PD represents a convenient technique to detect functional changes of the mucosa induced by aspirin, alcohol and bile acids. Antacids with potent buffering capacity are able to prevent reduction of PD-changes induced by aspirin and bile acids. Antacids therefore seem to exhibit a protective effect against acute lesions of the gastric mucosa.
D000863:Antacids / Q000494:pharmacology; D001241:Aspirin / Q000494:pharmacology; D001647:Bile Acids and Salts / Q000494:pharmacology; D002792:Cholestyramine Resin / Q000494:pharmacology; D000431:Ethanol / Q000494:pharmacology; D005753:Gastric Mucosa / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D008564:Membrane Potentials; D011199:Potentiometry / Q000379:methods
D000863:Antacids; D001647:Bile Acids and Salts; D002792:Cholestyramine Resin; D000431:Ethanol; D001241:Aspirin
Transmurale elektrische Potentialdifferenz-Messung als Funktionsparameter der Magenmukosaschranke.