[Experimental venous thrombosis in guinea pigs: effect of heparin and drugs affecting platelet function (author's transl)].
Thrombosis was induced in the jugular vein of guinea pigs by damage of the epithelium with a sclerosing solution. The effect of heparin, Dextran 70, acetylsalicylic acid, dypriridamole and phenilbutazone in preventing the development of the thrombus was investigated. Only heparin in high doses showed this effect.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000925:Anticoagulants / Q000627:therapeutic use*; D001241:Aspirin / Q000494:pharmacology; D001792:Blood Platelets / Q000187:drug effects; D003911:Dextrans / Q000494:pharmacology; D004176:Dipyridamole / Q000494:pharmacology / Q000627:therapeutic use*; D004341:Drug Evaluation; D006168:Guinea Pigs; D006493:Heparin / Q000494:pharmacology; D010653:Phenylbutazone / Q000494:pharmacology; D013924:Thrombophlebitis / Q000188:drug therapy*
D000893:Anti-Inflammatory Agents; D000925:Anticoagulants; D003911:Dextrans; D004176:Dipyridamole; D006493:Heparin; D010653:Phenylbutazone; D001241:Aspirin
Trombose venosa experimental na cobaia: efeito da heparina e de drogas que alteram a fundão plaquetaria.