[Pharmacological activity of progesterone derivatives].
Tests conducted on rabbits demonstrated that the progesterone derivatives--megestol-acetate, mepregnol-diacetate, melengestrol-acetate, megestro-capronate--display a higher progestagenic action than do progesterone and pregnene. Tests with rats revealed the contraceptive action to be highest with a long-term administration of low doses of mestranol and melengestrol-acetate (ratio of 1:50), or with introduction of mestranol and megpregno-diacetate (ratio of 1:20). When used together with mestranol megestrol-capronate manifests a greater ability of prolonged action and a higher effectiveness in the pre-implantation period as compared to a combination of megestrol-acetate and mestranol.
D000818:Animals; D003278:Contraceptives, Oral, Hormonal; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D005003:Ethisterone / Q000494:pharmacology; D005260:Female; D008535:Megestrol / Q000494:pharmacology; D008552:Melengestrol Acetate / Q000494:pharmacology; D011374:Progesterone / Q000031:analogs & derivatives* / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D013329:Structure-Activity Relationship; D013997:Time Factors
D003278:Contraceptives, Oral, Hormonal; D004338:Drug Combinations; D011374:Progesterone; D008552:Melengestrol Acetate; D008535:Megestrol; D005003:Ethisterone
Farmakologicheskaia aktivnost' nekotorykh proizvodnykh progesterona.