Diminishing hypotensive effect of increasing doses of pindolol in DOCA/saline hypertensive rats.
In DOCA-saline hypertensive rats, pindolol (4, 20 or 50 mg/kg orally) produced a hypotensive effect which was inversely related to dose. Following adrenal demedullation, a hypotensive response to the highest dose of pindolol was unmasked and the magnitude of the responses to lower doses was increased. The results suggest that adrenal catecholamines moderate the hypotensive effects of high doses of pindolol.
D000315:Adrenalectomy; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D003900:Desoxycorticosterone; D004305:Dose-Response Relationship, Drug; D006973:Hypertension / Q000139:chemically induced / Q000503:physiopathology*; D010869:Pindolol / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D003900:Desoxycorticosterone; D010869:Pindolol