Effect of cessation of propranolol treatment on myocardial noradrenaline and acetylcholine content in the rat.
Cessation of long-term treatment of rats with propranolol 10 mg/kg/day subcutaneously produced no alteration in the myocardial noradrenaline content estimated 12, 24, 48 and 96 hours after the last propranolol injection; nor did the myocardial acetylcholine content change. These results do not support the idea that the withdrawal-rebound phenomenon caused by abrupt cessation of propranolol therapy is associated with an accumulation of the autonomic neurotransmitters in myocardial tissue.
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism*; D011433:Propranolol / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D011433:Propranolol; D000109:Acetylcholine; D009638:Norepinephrine