Effect of vagal stimulation on the concentration of gastrin in serum and antral mucosa in dogs.
The concentration of gastrin in serum and antral mucosa was studied in anesthetized dogs after electrical stimulation of the antral branch vagus nerve. Vagal stimulation caused immediate and sustained release of gastrin into the circulation. After stimulation for one hour, the gastrin concentration of antral mucosa increased significantly. This suggests that vagal release of gastrin triggers its rapid synthesis.
D000818:Animals; D004285:Dogs; D004558:Electric Stimulation; D005753:Gastric Mucosa / Q000378:metabolism*; D005755:Gastrins / Q000097:blood / Q000378:metabolism*; D011706:Pyloric Antrum / Q000378:metabolism*; D014630:Vagus Nerve / Q000502:physiology*
D005755:Gastrins