[Lactate dehydrogenase (LDH) and isoenzymes in pig liver during postnatal development].
1. LDH-activity in the liver of newborn piglets is 4 times that of adult pig sliver and remains relatively constant at this level during the first 3 weeks of life. 2. 90% of LDH is localized in the cytosolic compartment of the liver, independent of age of pigs. 3. In the liver of newborn piglets the isoenzymes LDH-3 and LDH-4 includes the main part of LDH-activity. The typical distribution of LDH isoenzymes in the liver of adult pigs (LDH-3 greater than LDH-2 greater than LDH-1 greater than LDH-4 greater than LDH-5) is already reached in 6-day-old piglets. Afterwards there follows only a decrease of LDH-1. Therefore, during postnatal development a directed shift from M- to H-type of isoenzyme distribution is observed.
D000375:Aging; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism; D004592:Electrophoresis, Starch Gel; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D008099:Liver / Q000201:enzymology* / Q000254:growth & development; D008722:Methods; D013552:Swine / Q000378:metabolism*
D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase
Das Verhalten der Laktatdehydrogenase und ihrer Isoenzyme in der Ferkelleber während der postnatalen Entwicklung.