Theophylline bioavailability following oral administration of six sustained-release preparations.
Plasma theophylline concentrations were measured in 20 adults after single doses of 8 mg/kg of each of six oral sustained-release theophylline preparations. Twelve subjects were studied in a multiple-dose trial. Comparison of bioavailability and absorption characteristics suggest usefulness of some of these products for the purpose of maintaining safe and effective blood levels with twice-a-day dosing.
D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D003692:Delayed-Action Preparations; D004341:Drug Evaluation; D006801:Humans; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced; D013614:Tachycardia, Paroxysmal / Q000139:chemically induced; D013806:Theophylline / Q000097:blood / Q000378:metabolism*; D014202:Tremor / Q000139:chemically induced
D003692:Delayed-Action Preparations; D013806:Theophylline