Effects of anesthetics on diphenylhydantoin metabolism in the rat: possible inhibition by diethyl ether.
The effects of diethyl ether and urethane on the elimination of diphenylhydantoin (DPH) in the rat were compared. The apparent half-life of DPH following a dose of 10 mg/kg, iv, under continuous ether anesthesia was 284 +/- 47 min, while the half-life under urethane anesthesia was 25.5 +/- 6.3 min. The latter was in agreement with the literature value for DPH half-life without anesthesia. The effects of both anesthetic agents on bile flow and indocyanine green clearance were not different. Following intravenous administration of DPH (1 mg/kg), DPH metabolites excreted in bile at 2 h were 75.3 +/- 4.8% of the dose with urethane anesthesia and 25.0 +/- 5.0% of the dose with continuous ether anesthesia. The data suggest that ether may inhibit the DPH metabolism in vivo, most likely at the hydroxylation step, while urethane does not.
D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D001646:Bile / Q000378:metabolism; D003864:Depression, Chemical; D004347:Drug Interactions; D004986:Ether / Q000494:pharmacology*; D005019:Ethyl Ethers / Q000494:pharmacology*; D007208:Indocyanine Green; D007700:Kinetics; D008297:Male; D010672:Phenytoin / Q000378:metabolism*; D051381:Rats; D013997:Time Factors; D014520:Urethane / Q000494:pharmacology
D000777:Anesthetics; D005019:Ethyl Ethers; D004986:Ether; D014520:Urethane; D010672:Phenytoin; D007208:Indocyanine Green