Hypoprothrombinemia: case report.
A patient with a significant history of spontaneous and posttraumatic bleeding was found to have hypoprothrombinemia. His prothrombin (factor II) activity by clotting assay was 9.5% and his factor II antigen was 5%. Crossed immunoelectrophoresis and sucrose density gradient ultracentrifugation of the patient's plasma showed his prothrombin to be qualitatively indistinguishable from normal prothrombin by these techniques.
D000328:Adult; D001780:Blood Coagulation Tests; D002499:Centrifugation, Density Gradient; D006801:Humans; D007020:Hypoprothrombinemias / Q000097:blood* / Q000276:immunology; D007123:Immunoelectrophoresis, Two-Dimensional; D008297:Male