Red blood cell transketolase activity and the effect of thiamine supplementation in patients with chronic liver disease.
Biochemical evidence of thiamine deficiency was found in 58% of patients with chronic liver disease, the incidence being higher in alcoholic than in non-alcoholic patients. Daily supplementation with high doses of thiamine hydrochloride (200 mg/day) for one week restored levels of thiamine pyrophosphate (TPP), the active co-enzyme form of thiamine, to normal in all cases. Such supplementation also stimulated synthesis of the TPP dependent enzyme transketolase. Because of the essential role of TPP as a co-factor in intermediary metabolism, it is concluded that high doses of thiamine should be included in the routine nutritional management of patients with severe chronic liver disease.
D001205:Ascorbic Acid / Q000008:administration & dosage; D002908:Chronic Disease; D004912:Erythrocytes / Q000201:enzymology*; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000201:enzymology / Q000378:metabolism; D008107:Liver Diseases / Q000201:enzymology / Q000378:metabolism*; D011736:Pyridoxine / Q000008:administration & dosage; D013831:Thiamine / Q000627:therapeutic use* / Q000652:urine; D013832:Thiamine Deficiency / Q000188:drug therapy* / Q000201:enzymology; D014174:Transketolase / Q000097:blood*
D014174:Transketolase; D011736:Pyridoxine; D001205:Ascorbic Acid; D013831:Thiamine