Generalized argyria. Clinicopathologic features and histochemical studies.
In three cases of generalized argyria, the degree of slate-gray cutaneous discoloration varied from barely perceptible to pronounced. Deposition of silver-containing granules in and around cutaneous adnexal structures was best seen with darkfield microscopy. Histochemical studies suggested that the granules consisted of silver sulfide. Indiscriminate use of currently available silver-containing medications can result in generalized argyria.
D000368:Aged; D001129:Argyria / Q000209:etiology / Q000473:pathology*; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000473:pathology*