[Pathomorphological reactions and noradrenalin content of the heart after administration of depot angiotensin in trained and untrained rats].
A 14-days' training of rats designed to adapt the animals to the procedure of blood-pressure measurement caused in the myocardium a decrease, in serum an increase in noradrenaline ( NA) content. The latter remained unchanged following 3 days of treatment with 2.5 mg depot angiotensin II (AII) but decreased by more than one-half in the myocardium of untreated animals, and increased in serum. Despite the considerable difference in myocardial NA content and blood-pressure behaviour, both trained and untrained rats showed the same morphological reactions following administration of A II. These myocardial alterations which largely correspond to the so-called epinephrine myocarditis should not therefore be due solely to NA action; rather, the involvement of A II should be considered also.
D000222:Adaptation, Physiological; D000804:Angiotensin II / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003692:Delayed-Action Preparations; D008297:Male; D009206:Myocardium / Q000032:analysis*; D009638:Norepinephrine / Q000032:analysis* / Q000097:blood; D051381:Rats
D003692:Delayed-Action Preparations; D000804:Angiotensin II; D009638:Norepinephrine
Pathomorphologische Reaktionen und Noradrenalingehalt des Herzens nach Applikation von Depot-Angiotensin bei trainierten und untrainierten Ratten.