Cytotoxic effects of emetine hydrochloride in the kidney of Long-Evans rats.
Emetine hydrochloride has been used to study its effects in the rat kidney, Sublethal doses of the drug at 10.0 mg/kg body weight of the animal were administered at 12 and 24 h intervals. Certain morphological changes occurred within the kidney. These changes involved the formation of vacuoles, swelling of mitochondria, disruption of basal membranes, deterioration of red blood cells, production of convoluted membranes and fibril-like structures. The earliest changes were observed 12 h after treatment with the drug.
D000818:Animals; D001485:Basement Membrane / Q000648:ultrastructure; D004305:Dose-Response Relationship, Drug; D004640:Emetine / Q000008:administration & dosage / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects* / Q000648:ultrastructure; D008297:Male; D008933:Mitochondrial Swelling; D051381:Rats; D011919:Rats, Inbred Strains; D014617:Vacuoles / Q000648:ultrastructure
D004640:Emetine