Alkaloids of Strychnos dolichothyrsa Gilg ex Onochie et Hepper.
Three alkaloids of the stem bark of Strychnos dolichothyrsa Gilg ex Onochie et Hepper (Loganiaceae) were isolated and identified as caracurine V and its mono- and di-N-oxide by comparison with synthesized compounds. 13C-NMR was used to confirm the structure of the N-oxides. The muscle relaxant activity and the toxicity of the N-oxides were less than those of caracurine V.
D000470:Alkaloids / Q000138:chemical synthesis / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D002855:Chromatography, Thin Layer; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009125:Muscle Relaxants, Central
D000470:Alkaloids; D009125:Muscle Relaxants, Central