[Hemodynamic effects of obzidan in vasorenal hypertension in dogs in ontogeny].
Vasorenal hypertension was reproduced in experiments on 18--22 day-old and 2--3-month-old puppies and on sexually-mature dogs by bilateral stenosis of the renal arteries. Two weeks later all the animals were given intravenous infusion of obzidan in a dose of 2 mg/kg. The arterial pressure, the minute and systolic volumes (MV, SV), total peripheral resistance (TPR), and the work, strength, and phase structure of the left ventricle were recorded. In animals aged 18--22 days with elevated pressure, obzidan infusion promoted its normalization, led to a decrease in the increased MO to subnormal values, a decrease in TPR and the heart beat rate, and normalization of the increased SV. In puppies aged 2--3 months, obzidan normalized the pressure by causing a fall in the minute output which was already reduced in hypertension, and a certain decrease in TPR with hardly any changes occurring in SV. In adult dogs, despite a sharp decrease in MV, arterial pressure did not significantly change due to the increase in TPR. Energy expenditure per each liter of MV was normalized by obzidan only in puppies.
D000367:Age Factors; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003864:Depression, Chemical; D004285:Dogs; D006321:Heart / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006977:Hypertension, Renal / Q000188:drug therapy*; D009200:Myocardial Contraction / Q000187:drug effects; D011433:Propranolol / Q000627:therapeutic use*
D011433:Propranolol
Gemodinamicheskie éffekty obzidana pri vazorenal'noĭ gipertonii u sobak v ontogeneze.