The uptake of IgG and IgM coated sheep erythrocytes in perfused rabbit liver.
Erythrocytes sensitized with IgM and IgG (EA) are entrapped during perfusion of isolated rabbit liver. The binding of EIgG is of high affinity while that of EIgM is weak and partly reversible. Moreover, the binding of EIgM is dependent on the presence of Ca++ ions in the perfusion medium whilst the binding of EIgG is independent of divalent cations. No uptake of sensitized erythrocytes during perfusion of the inferior extremities of rabbits is found.
D000818:Animals; D000936:Antigen-Antibody Complex; D001665:Binding Sites; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D007074:Immunoglobulin G / Q000378:metabolism; D007075:Immunoglobulin M / Q000378:metabolism; D066298:In Vitro Techniques; D008099:Liver / Q000276:immunology* / Q000378:metabolism; D008297:Male; D011817:Rabbits
D000936:Antigen-Antibody Complex; D007074:Immunoglobulin G; D007075:Immunoglobulin M