Direct or proximate contact between cells and metabolic activation systems is required for mutagenesis.
D001580:Benzopyrenes / Q000494:pharmacology; D001711:Biotransformation; D002448:Cell Adhesion; D002462:Cell Membrane / Q000502:physiology; D002478:Cells, Cultured; D004128:Dimethylnitrosamine / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008769:Methylnitronitrosoguanidine / Q000378:metabolism; D008862:Microsomes, Liver / Q000378:metabolism*; D009153:Mutagens / Q000378:metabolism*
D001580:Benzopyrenes; D009153:Mutagens; D008769:Methylnitronitrosoguanidine; D004128:Dimethylnitrosamine