Lysine acetylisalicylate inhibits the protein synthesis in the rat gastric mucosa in vivo and in vitro.
Lysine acetylsalicylate (LAS), a water soluble derivative of acetylsalicylic acid and parenterally administrable analgesic, locally inhibits the incorporation of 14C protein hydrolysate into proteins of the rat isolated gastric mucosa. A similar effect on protein synthesis was observed after s.c. administration of the drug, whereas DNA and RNA synthesis were not affected. Obviously, LAS inhibits the translation step during biosynthesis of proteins. It is conceivable that this effect contributes to the potential ulcerogenic action of acetylsalicylate and that parenteral administration is not a criteria to protect the stomach from salicylate-induced side effects.
D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D066298:In Vitro Techniques; D008239:Lysine / Q000494:pharmacology; D008297:Male; D014176:Protein Biosynthesis; D051381:Rats
D008239:Lysine; D001241:Aspirin