A32390A, a new biologically active metabolite. II. Isolation and structure.
An inhibitor of dopamine-beta-hydroxylase, designated A32390A, was isolated from the culture broth of a Pyrenochaeta species. The inhibitor showed antimicrobial activity against fungi and gram-positive bacteria. Spectroscopic analysis and chemical degradation studies indicated that the structure was 1,6-di-O-(2-isocyano-3-methylcrotonyl)-D-mannitol.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D004352:Drug Resistance, Microbial; D005658:Fungi / Q000187:drug effects; D008297:Male; D008353:Mannitol / Q000031:analogs & derivatives* / Q000302:isolation & purification; D051379:Mice; D009206:Myocardium / Q000032:analysis; D009570:Nitriles / Q000302:isolation & purification; D009638:Norepinephrine / Q000032:analysis; D051381:Rats
D000900:Anti-Bacterial Agents; D009570:Nitriles; D008353:Mannitol; C014930:A32390A; D009638:Norepinephrine