Effects of certain antitumor platinum compounds on kidney esterases.
In a study of the biochemical mechanism of renal toxicity of certain antitumor platinum compounds, particularly cis-dichlorodiammineplatinum(II) (NSC-119875), qualitative and quantitative studies of the soluble nonspecific kidney esterases were carried out using (C57BL/L X DBA/2) mice. There was a major suppression of the testosterone-dependent esterases of treated male mice; these levels dropped to levels below those found in untreated females within 72 h after certain of the drugs were administered. This effect appeared to be in inverse relationship to the numerical value of the LD50 values of the compounds investigated.
D000818:Animals; D002945:Cisplatin / Q000494:pharmacology* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004950:Esterases / Q000378:metabolism*; D005260:Female; D007526:Isoelectric Point; D007668:Kidney / Q000201:enzymology*; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010984:Platinum / Q000494:pharmacology* / Q000633:toxicity; D012737:Sex Factors
D010984:Platinum; D004950:Esterases; D002945:Cisplatin