Immunopathology of the lens. I 86Rb efflux and protein leakage from normal lenses exposed to unrelated antigen-antibody interactions.
Normal rabbit lenses exposed in vitro to heterologous antibody (Ab)--antigen (Ag) interactions lose control of the intracellular 86Rb; this membrane damage, which seems to be related to the quantitative ratio Ab/Ag, is relatively complement independent and is followed by a subsequent leakage of lenticular proteins. A possible implication of these findings in the development of complicated cataracts in uveitis (as 'permeability cataracts') and in the self-maintenance of recurrent uveal inflammation is shortly discussed.
D000818:Animals; D000937:Antigen-Antibody Reactions; D002463:Cell Membrane Permeability; D003165:Complement System Proteins; D005136:Eye Proteins / Q000378:metabolism*; D007908:Lens, Crystalline / Q000276:immunology* / Q000378:metabolism; D011817:Rabbits; D011868:Radioisotopes; D012413:Rubidium
D005136:Eye Proteins; D011868:Radioisotopes; D003165:Complement System Proteins; D012413:Rubidium