Aflatoxin metabolism and absence of cytochrome P-450 in rat colon tissue during vitamin A malnutrition.
Homogenized mucosal linings prepared from vitamin A adequate and deficient male rats were used in metabolic studies of aflatoxin B1 (AFB1). Cytochrome P-420 was identified in both groups which metabolized AFB1 to 4 metabolic products in vitro. The implications of this observation are discussed in relation to colon carcinoma.
D000348:Aflatoxins / Q000378:metabolism*; D000818:Animals; D003106:Colon / Q000201:enzymology / Q000378:metabolism*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000201:enzymology / Q000378:metabolism; D008297:Male; D051381:Rats; D014802:Vitamin A Deficiency / Q000378:metabolism*
D000348:Aflatoxins; D003577:Cytochrome P-450 Enzyme System