[Studies using loperamide in patients with diarrhea following telecobalt irradiation of malignant abdominal tumors (author's transl)].
45 patients with diarrheas appearing after exposure of the gastro-intestinal region to ionizing radiation were given loperamide in the course of a study. A few days after administration of the loperamide, normalization of the stools took place, except in three cases. Simultaneous tenesmic gripes, some of the patients had also suffered from, disappeared completely, with the exception of two cases where, however, normalization of the stools was obtained by means of the loperamide therapy. Subjective side-effects did not occur. Also no alterations of the blood count, hematological features, liver function tests or urine have been observed.
D000008:Abdominal Neoplasms / Q000532:radiotherapy; D000328:Adult; D000368:Aged; D003967:Diarrhea / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008139:Loperamide / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D010880:Piperidines / Q000627:therapeutic use*; D011832:Radiation Injuries / Q000188:drug therapy*; D011867:Radioisotope Teletherapy / Q000009:adverse effects
D010880:Piperidines; D008139:Loperamide
Studien mit Loperamide an Patienten mit Diarrhoe nach Telekobalt-Strahlenbehandlung maligner Tumoren im Abdominalbereich.