[Comparative study of energy metabolism of the skeletal muscles in man, dogs and rats during long-term ischemia].
A comparative investigation was made on muscle tissue of man, dog and rat during ischemia of five hours duration. The content of energy rich phosphates was measured. The ATP level decreased after two hours ischemia to 68% in man, to 45% in the dog, and to 23% in the rat. By five hours it had fallen further to 25% in man, 9% in the dog and only 1% in the rat. It is concluded that human muscle has a higher tolerance to ischemia.
D000244:Adenosine Diphosphate / Q000032:analysis; D000249:Adenosine Monophosphate / Q000032:analysis; D000255:Adenosine Triphosphate / Q000032:analysis; D000818:Animals; D003401:Creatine / Q000032:analysis; D004285:Dogs; D004734:Energy Metabolism; D006003:Glycogen / Q000032:analysis; D006801:Humans; D007511:Ischemia / Q000378:metabolism*; D007773:Lactates / Q000032:analysis; D009132:Muscles / Q000098:blood supply* / Q000378:metabolism*; D010725:Phosphocreatine / Q000032:analysis; D051381:Rats; D013997:Time Factors
D007773:Lactates; D010725:Phosphocreatine; D000249:Adenosine Monophosphate; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D006003:Glycogen; D003401:Creatine
Vergleichende Untersuchungen des Energiestoffwechsels der Skeletmuskulatur von Mensch, Hung und Ratte während langfristiger Ischämie.