The antiarrhythmic effect of prostaglandin E2 on catecholamine-induced arrhythmias.
The antiarrhythmic effect of PGE2 as compared with the adrenergic beta-receptor blocking substance propranolol and the unspecific antiarrhythmic agent ajmaline was examanined on catecholamine-induced arrhythmias of the guinea-pig after preliminary sensibilisation by means of chloroform. Prophylactic administration of the tested substances resulted in a decrease in severity of arrhythmia by 91% after propranolol, by 37% after PGE2 and by 34% after ajmaline. Onset and duration of the arrhythmia were affected only to a negligible degree. The possible mode of action is still under discussion.
D000404:Ajmaline / Q000627:therapeutic use; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy*; D002395:Catecholamines / Q000009:adverse effects*; D005260:Female; D006168:Guinea Pigs; D008297:Male; D011433:Propranolol / Q000627:therapeutic use; D011458:Prostaglandins E / Q000627:therapeutic use*
D002395:Catecholamines; D011458:Prostaglandins E; D000404:Ajmaline; D011433:Propranolol