Gas chromatography mass spectrometry studies on biologically important 8-aminoquinoline derivatives.
Several substituted 8-aminoquinolines related to known antimalarial drugs have been studied by gas chromatography mass spectrometry. 5,6-Dihydroxy-8-aminoquinoline, a possible metabolite of Primaquine, can be detected by single ion monitoring after conversion to a trimethylsilyl ether derivative. The mass spectra obtained in this study indicate that there are certain ions which are characteristic of the trimethylsilyl ethers of hydroxylated 8-aminoquinolines and 5,6-dimethoxy-8-aminoquinolines. These compounds should thus be amenable to analysis if they were produced during in vivo metabolism studies. Using selected ion monitoring the derivatized compounds can be detected at submicrogram levels.
D000634:Aminoquinolines / Q000097:blood; D001711:Biotransformation; D002849:Chromatography, Gas; D006801:Humans; D013058:Mass Spectrometry; D011319:Primaquine / Q000097:blood / Q000378:metabolism*
D000634:Aminoquinolines; D011319:Primaquine