Hemodynamic changes in burned mice treated with triglycylvasopressin.
Cardiac output distribution, blood pressure and flow in a carotid artery catheter during the first five days after a standardized 15% third degree burn were studied in groups of mice treated with triglycylvasopressin, and in groups used as controls. All animals received isotonic saline solution amounting to 20% of the body weight twice daily, and the treated groups received in addition triglycylvasopressin (TGLVP), a vasopressin analogue with prolonged effect, 100 microgram/kg body weight twice daily. Cardiac output distribution was determined by the 86Rubidium-technique, and showed in burned animals a decreasing fraction to kidneys and small bowel as well as an increased share to the carcass during the experimental period. These changes were partly counteracted by TGLVP-treatment. Flow in the carotid artery catheter in the treated group far exceeded that in the controls, which might be explained by a lower viscosity of the blood in the treated group.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001809:Blood Viscosity / Q000187:drug effects; D002056:Burns / Q000188:drug therapy* / Q000503:physiopathology; D002302:Cardiac Output / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D051379:Mice; D012039:Regional Blood Flow / Q000187:drug effects; D014667:Vasopressins / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use
D014667:Vasopressins