[Hemodynamic parameters and plasma-renin activity following intravenous dihydralazine administration--a contribution to the regulation of renin].
On account of the complex effective mechanism the control of dihydralazin is performed particularly with regard to the changes of the plasma-renin-activity. The examinations were carried out in 7 patients each with renal and essential hypertension. The plasma-renin-activity, the behaviour of blood pressure, the stroke volume and the minute volume as well as the peripheral arterial resistance should be examined concerning the influence of two doses of dihydralazin and with regard to the influence of the basic disease to the above mentioned parameters. The plasma-renin-activity is decreased as well as increased by dihydralazin. Baroreceptors are made responsible for the renin regulation. Already with 4.125 mg dihydralazin (1/8 ampoule Depressan) nearly the same permanent effect reducing the blood pressure is to be achieved as with a double dosage. Stroke volume and minute volume are reduced by dihydralazin. The peripheral arterial resistance decreases in no case, but in the renal hypertension it shows a rising tendency. With the help of these examinations it shall particularly referred to the fact that the therapeutic mechanism of the slowly beginning and long lasting decrease of blood pressure is not yet be fully clarified.
D000293:Adolescent; D000328:Adult; D001157:Arterial Occlusive Diseases / Q000188:drug therapy; D004078:Dihydralazine / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005921:Glomerulonephritis / Q000188:drug therapy; D006801:Humans; D006830:Hydralazine / Q000031:analogs & derivatives*; D006973:Hypertension / Q000188:drug therapy*; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D012077:Renal Artery; D012083:Renin / Q000097:blood*
D006830:Hydralazine; D012083:Renin; D004078:Dihydralazine
Hämodynamische Parameter und Plasma-Renin-Aktivität nach intravenöser Dihydralazingabe--ein Beitrag zur Reninregulation.