Hepatic disposition of tilorone hydrochloride in the rat.
1. The hepatic disposition of tilorone HCl, an antiviral and antitumour agent, was studied in male Wistar rats after intraduodenal administration. 2. A concentrative transfer into the liver occurred, the liver/portal blood concentration ratio being 120 or higher. The relationship between dose and hepatic concentration was linear. 3. Biliary excretion of tilorone was low and dose-related; whole blood concentration was also dose-related. 4. Neither hepatic concentration nor biliary excretion exhibited saturation over the dosage studied (6--174 mg/kg). The hepatic 'depot' of tilorone lacked the characteristics of a true 'first-pass' effect.
D000818:Animals; D001646:Bile / Q000378:metabolism; D005449:Fluorenes / Q000378:metabolism*; D007408:Intestinal Absorption; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D013994:Tilorone / Q000097:blood / Q000378:metabolism*; D013997:Time Factors
D005449:Fluorenes; D013994:Tilorone