Preoperative oral antacid therapy for patients requiring emergency surgery.
Preoperative oral antacid therapy has been used effectively to reduce the number of emergency obstetric patients "at risk" of developing acid-aspiration syndrome. Thirty-three nonobstetric adult patients requiring emergency surgery were selected to determine whether the protective effects of antacid therapy could also be derived in this high-risk group. Maalox-treated patients had a mean gastric pH of 6.46 +/- 0.5 and gastric volume 21.5 +/- 3.6 ml, with none at risk, whereas control patients had mean pH of 3.71 +/- 0.43, gastric volume 71.5 +/- 16.5 ml, and 42.1% at risk. This report suggests that preoperative antacid therapy should reduce the incidence of acid aspiration and subsequent morbidity and mortality in patients requiring emergency surgery.
D000284:Administration, Oral; D000536:Aluminum Hydroxide / Q000008:administration & dosage; D000768:Anesthesia, General; D000863:Antacids / Q000008:administration & dosage*; D004630:Emergencies; D005260:Female; D006801:Humans; D007441:Intubation, Gastrointestinal; D008276:Magnesium Hydroxide / Q000008:administration & dosage; D008297:Male; D011183:Postoperative Complications / Q000517:prevention & control; D012306:Risk; D013514:Surgical Procedures, Operative
D000863:Antacids; D000536:Aluminum Hydroxide; D008276:Magnesium Hydroxide