[A transurethrally transplanted model of a carcinoma in the area of the urinary bladder of the rabbit (author's transl)].
Thirty-nine rabbits were injected intratesticularly (n = 4), in the neck (n = 6), or in the submucosal area of the bladder (n = 29), with a 1-ml suspension of cells from a continuously passaged Brown-Pearce carcinoma. Actual submucosal transplantation (n = 9) caused, in addition to bladder tumors, massive metastases in the peritoneal cavity, the pleura, and the eyes. Animals receiving mucous membrane cornification prior to the submucosal infiltration (n = 15) developed exulcerated tumors in the bladder lumen and a primary bladder carcinoma like metastasis. Animals in which the tumor cell suspension was transplanted transurethrally (n = 5) likewise showed metastases in para-aortal lymph nodes and in the liver. The experiments indicate that the Brown-Pearce carcinoma, which is not indigenous to the bladder, will, with appropriate methodology, behave in a manner similar to that of a primary bladder carcinoma and can in addition be transplanted transurethrally. Tumors thus induced appear to be suitable models for studying different therapeutic approaches to bladder carcinoma.
D000818:Animals; D002284:Carcinoma, Brown-Pearce / Q000473:pathology*; D004195:Disease Models, Animal; D005134:Eye Neoplasms; D008297:Male; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation / Q000379:methods*; D009374:Neoplasms, Experimental / Q000473:pathology*; D010534:Peritoneal Neoplasms; D010997:Pleural Neoplasms; D011817:Rabbits; D014184:Transplantation, Homologous; D001749:Urinary Bladder Neoplasms / Q000473:pathology*
Transurethral transplantiertes Modell eines Karzinoms im Bereich der Harnblase des Kaninchens.