Management of alcohol withdrawal syndromes.
Withdrawal from alcohol (ethanol, ethyl alcohol) or other general sedatives leads to progressive hyperactivity that progresses from tremulousness, sleep disturbance, and hallucinosis, to the more serious rum fits and delirium tremens (DTs). Withdrawal can be prevented and, in most cases, arrested by prompt replacement of alcohol with paraldehyde, benzodiazepines or other general sedatives. Diazepam is appropriate replacement therapy for most patients. When delirium is manifest, the chance is greater than 15% that the patient will die, and this reaction cannot be aborted. The patient with DTs must be calmed with a general sedative that has a rapid onset of maximal effect to prevent overdosage. Diazepam, 5 mg intravenously every five minutes, permits evaluation of the maximal effect of each dose before the next dose is administered. Although some patients have advance sedative or alcohol withdrawal, great care must be taken to elicit the proper history of alcohol abuse so that sedative replacement therapy will prevent or abort early withdrawal, thus sparing the patient a mortality equivalent to that of acute myocardial infarction or Russian roulette.
D000428:Alcohol Drinking; D000430:Alcohol Withdrawal Delirium / Q000517:prevention & control*; D000437:Alcoholism / Q000534:rehabilitation*; D003975:Diazepam / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D004361:Drug Tolerance; D000431:Ethanol / Q000008:administration & dosage; D006212:Hallucinations / Q000209:etiology; D006801:Humans; D009759:Nystagmus, Pathologic / Q000209:etiology; D010242:Paraldehyde / Q000627:therapeutic use; D011604:Psychoses, Alcoholic / Q000517:prevention & control*; D012640:Seizures / Q000209:etiology; D012893:Sleep Wake Disorders / Q000209:etiology; D014202:Tremor / Q000209:etiology
D000431:Ethanol; D003975:Diazepam; D010242:Paraldehyde