Radionuclide imaging of metastases from renal-cell carcinoma by 131I-labeled antitumor antibody.
On immunofluorescence assay, goat antisera reacted with renal-cell carcinomas from 20 patients, but not with adult normal human tissues (including patient's normal kidney). After in travenous injection, the 131I-labeled antibody localized preferentially in metastatic renal carcinoma in 6 consecutive patients. Labeled antitumor antibodies may have the specificity for tumor imagining which current radiopharmaceuticals lack.
D000230:Adenocarcinoma / Q000000981:diagnostic imaging* / Q000276:immunology; D000818:Animals; D000912:Antibodies, Neoplasm; D001859:Bone Neoplasms / Q000000981:diagnostic imaging; D005260:Female; D006041:Goats / Q000276:immunology; D006801:Humans; D007457:Iodine Radioisotopes; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging* / Q000276:immunology; D008297:Male; D008479:Mediastinal Neoplasms / Q000000981:diagnostic imaging; D009362:Neoplasm Metastasis / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D012535:Scalp / Q000000981:diagnostic imaging; D012878:Skin Neoplasms / Q000000981:diagnostic imaging; D013977:Tibia / Q000000981:diagnostic imaging
D000912:Antibodies, Neoplasm; D007457:Iodine Radioisotopes