Factor VIII activity and antigen in sick newborns with pathological proteolysis in blood.
Factor VIII clotting activity (VII:C) and factor VIII related antigen (VIII:R:AG) were determined in 12 sick newborn infants with pathological proteolysis in their circulation. A marked discrepancy was noted between VIII:R:AG and VIII:C, the ratio in sick infants being, on average, 2:1, while no discrepancy was seen in healthy newborns. The finding in the sick infants resembled a low grade plasminogen activation, which was studied experimentally. It is concluded that demonstration of a marked discrepancy between VIII:R:AG and VIII:C is a useful indication of pathologic proteolysis in sick newborns.
D000941:Antigens / Q000032:analysis; D001238:Asphyxia Neonatorum / Q000097:blood; D001777:Blood Coagulation; D001796:Blood Protein Disorders / Q000097:blood*; D001798:Blood Proteins / Q000032:analysis; D005169:Factor VIII / Q000032:analysis; D006801:Humans; D007123:Immunoelectrophoresis, Two-Dimensional; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000097:blood*; D012127:Respiratory Distress Syndrome, Newborn / Q000097:blood
D000941:Antigens; D001798:Blood Proteins; D005169:Factor VIII