Modifications of the biological activity of anti-D immunoglobulin caused by heat aggregation.
Some of the biological activities known to be confined to certain anti-D sera such as Ripley could be simulated using heat-treated human anti-D Ig preparations. Thus, human red cells sensitized with heat-treated anti-D Ig were found to be capable of causing Fc-receptor on lymphocyte surfaces and of fixing complement. In its other effects such as reactivity to rheumatoid factor and to anti-allotype agglutinators, heat-treated anti-D Ig seemed inferior to such anti-D sera as Ripley.
D002850:Chromatography, Gel; D003165:Complement System Proteins / Q000378:metabolism; D006358:Hot Temperature; D006801:Humans; D007106:Immune Sera / Q000494:pharmacology; D007126:Immunoglobulin Allotypes; D007141:Immunoglobulin Fc Fragments; D007136:Immunoglobulins; D012217:Rheumatoid Factor / Q000494:pharmacology; D012397:Rosette Formation
D007106:Immune Sera; D007126:Immunoglobulin Allotypes; D007141:Immunoglobulin Fc Fragments; D007136:Immunoglobulins; D003165:Complement System Proteins; D012217:Rheumatoid Factor