Immunogenetic aspects of nasopharyngeal carcinoma. V. Confirmation of a Chinese-related HLA profile (A2, Singapore 2) associated with an increased risk in Chinese for nasopharyngeal carcinoma.
Histocompatibility locus A typing of 43 Malaysian Chinese and 51 Hong Kong Chinese patients with nasopharyngeal carcinoma (NPC) confirmed the association between the occurrence of A2-Sin 2 and the increased risk for NPC that was previously demonstrated in Singapore Chinese. The results support the previous interpretation that the histocompatibility locus A genotype of importance in NPC predisposition is the A2-Sin 2 haplotype. The histocompatibility locus A-linked, genetically determined NPC risk is common to Asian Chinese from at least three geographic locations.
D044466:Asian People; D002681:China / Q000208:ethnology; D006680:HLA Antigens; D006723:Hong Kong; D006801:Humans; D008296:Malaysia; D009303:Nasopharyngeal Neoplasms / Q000235:genetics / Q000276:immunology*; D010641:Phenotype; D012306:Risk; D012846:Singapore
D006680:HLA Antigens