Reduction by linoleic acid of the severity of experimental allergic encephalomyelitis in the guinea pig.
This paper reports the effects of supplementation of the diet with linoleic acid on the severity of experimental allergic encephalomyelitis (EAE) in guinea pigs. Clinical signs of disease (e.g. paresis, paraplegia, urinary incontinence), weight loss, frequency of perivascular lesions in the central nervous system and ability of isolated lymph node cells to respond to myelin basic protein in vitro were all reduced by linoleic acid supplementation. Linoleic acid was effective when fed at a dose of 0.5 ml/day from 7 to 21 days after sensitization of the animals with basic protein, i.e., before and during the time in which clinical signs normally appeared. The same daily dose fed from 7 days before to 7 days after sensitization, i.e., ceasing about 7 days before the normal time of appearance of clinical signs, produced no significant effect. Feeding linoleic acid to normal guinea pigs significantly altered the fatty acid composition of their serum and lymph nodes, but not of their brain. Of several possible explantations for the protective effect of lineolic acid in EAE, we considered action by this essential fatty acid on the immune system most likely.
D000818:Animals; D001921:Brain / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D005260:Female; D006168:Guinea Pigs; D008041:Linoleic Acids / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use*; D008198:Lymph Nodes / Q000187:drug effects; D009103:Multiple Sclerosis / Q000188:drug therapy; D009829:Oleic Acids / Q000097:blood / Q000627:therapeutic use; D010169:Palmitic Acids / Q000097:blood; D013116:Spinal Cord / Q000473:pathology; D013229:Stearic Acids / Q000097:blood; D013997:Time Factors
D008041:Linoleic Acids; D009829:Oleic Acids; D010169:Palmitic Acids; D013229:Stearic Acids