Contribution to the regulatory role of insulin in inflammation and anaphylaxis.
Insulin, in doses which did not influence the blood sugar level, potentiated the anaphylactic shock in ovalbumin-sensitized CFLP mice and moderately inhibited the carrageenan-induced paw edema. Higher doses were found to produce a dose-dependent inhibition of the inflammatory process at the 2nd hour, and caused less suppression at the 4th hour of the swelling. These results suggest that insulin may play a complex regulatory role in hypersensitivity and inflammatory reactions, and its effect is not necessarily related to hypoglycemia.
D000707:Anaphylaxis / Q000503:physiopathology*; D000818:Animals; D002351:Carrageenan; D004305:Dose-Response Relationship, Drug; D007249:Inflammation / Q000139:chemically induced / Q000517:prevention & control*; D007328:Insulin / Q000008:administration & dosage / Q000276:immunology*; D008297:Male; D051379:Mice
D007328:Insulin; D002351:Carrageenan