Ethanol and spinal presynaptic inhibition in man.
Ethanol, 0.65 gm per kilogram of body weight, was administered orally to 6 normal subjects. The mean blood ethanol levels ranged from 0.74 to 0.99 gm per liter over a subsequent 40-minute testing period. The proportion of the soleus motoneuron pool activated by the Achilles tendon reflex was reduced. Vibratory inhibition of the monosynaptic reflex was used as an estimate of spinal presynaptic inhibition. It was unaffected by ethanol.
D000328:Adult; D000428:Alcohol Drinking; D000435:Alcoholic Intoxication / Q000503:physiopathology; D004558:Electric Stimulation; D000431:Ethanol / Q000097:blood / Q000494:pharmacology*; D006801:Humans; D007866:Leg / Q000294:innervation; D009046:Motor Neurons / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects; D009433:Neural Inhibition / Q000187:drug effects*; D012023:Reflex, Monosynaptic / Q000187:drug effects; D012026:Reflex, Stretch / Q000187:drug effects; D013116:Spinal Cord / Q000187:drug effects*; D013569:Synapses / Q000187:drug effects*
D000431:Ethanol