[Position and problems is morphological characterizing of aged cells and organs (author's transl)].
Cellular changes in the process of aging are non-specific. A combination of nuclear inclusions, invaginations of the nuclear membrane, a reduction of the number of mitochondria with a simultaneous increase in size to the point of development of megamitochondria, a disorganization of the endoplasmic reticulum and a decrease of its surface density, an increase of the lysosomal volume share and a lipofucin accumulation indicates the existance of an aged cell. On the macroscopical and microscopical levels a diagnosis on the age of an organ is impossible.
D000328:Adult; D000367:Age Factors; D000368:Aged; D000818:Animals; D001921:Brain / Q000166:cytology; D002452:Cell Count; D002467:Cell Nucleus / Q000648:ultrastructure; D002470:Cell Survival; D002477:Cells / Q000648:ultrastructure*; D004386:Duodenum / Q000166:cytology; D006801:Humans; D007583:Jejunum / Q000166:cytology; D008099:Liver / Q000166:cytology; D051379:Mice; D008875:Middle Aged; D008928:Mitochondria / Q000648:ultrastructure; D008930:Mitochondria, Liver; D051381:Rats; D013499:Surface Properties
Stand und Probleme der morphologischen Charakterisierung alter Zellen und Organe.