[Chemically induced carcinogenesis of stomach of the rat after vagotomy and resection (author's transl)].
180 male Wistar-rats were daily exposed to 30 and 100 mg MNNG/1000 ccm tapwater. After 7 weeks exposure a truncal vagotomy with pyloroplasty or a Billroth-II-resection was performed in 25 animals of each dosage-group. 80 rats were not operated. The incidence of carcinomas in the Billroth-II-rats of both dosage-groups was evidently higher than in the exposed controls. In the vagotomized rats an increased occurrence of carcinomas could not be observed.
D000818:Animals; D005743:Gastrectomy; D008297:Male; D008769:Methylnitronitrosoguanidine / Q000008:administration & dosage; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D011708:Pylorus / Q000601:surgery; D051381:Rats; D013274:Stomach Neoplasms / Q000139:chemically induced*; D013997:Time Factors; D014628:Vagotomy
D008769:Methylnitronitrosoguanidine
Chemisch induzierte Karzinogenese des Rattenmagens nach Vagotomie und Resektion.