[Actinomyces streptomycini mutants blocked in the biosynthesis of the streptobiosamine portion of the streptomycin molecule].
Four low active mutants of Act. streptomycini were obtained under the effect of nitrozo-methylbiuret. The mutants increased their antibiotic production level, when streptobiosamine was present in the formentation medium. It was shown that in 3 out of the 4 mutants the highest antibiotic yield was in the medium containing streptobiosamine in an amount of 1 mg/ml and in 1 strain the highest yield was in the medium with 0.5 mg/ml of streptobiosamine. When the mutants were grown in a medium containing N-methyl-L-glucosamine no increase in streptomycin production was registered.
D001737:Biuret / Q000031:analogs & derivatives / Q000494:pharmacology; D003470:Culture Media; D004187:Disaccharides / Q000096:biosynthesis*; D008968:Molecular Conformation; D009154:Mutation / Q000187:drug effects; D013302:Streptomyces / Q000187:drug effects / Q000378:metabolism*; D013307:Streptomycin / Q000096:biosynthesis*
D003470:Culture Media; D004187:Disaccharides; C016762:streptobiosamine; D001737:Biuret; D013307:Streptomycin
Mutanty Actinomyces streptomycini, blokirovannye po biosintezu streptobiozaminovoĭ chasti molekuly streptomitsina.