Effects of delta1-trans-tetrahydrocannabinol on mechanical performance of isolated heart muscle preparations.
1 The effects of four concentrations of delta1-trans-tetrahydrocannabinol (delta1-THC) (0.1, 1, 5 and 20 microgram/ml) were compared to that of the vehicle (ethanol, 0.5 microliter/ml) on the mechanical performance of isolated cardiac muscle of the cat and rat. 2 In rat isolated papillary muscles, delta1-THC (20 microgram/ml) caused a decline in mechanical performance (-8% in developed tension and -11% in Vmax) in contrast to the apparent lack of effect of ethanol. 3 All other parameters of mechanical performance studied in both rat and cat papillary muscles were unaffected by delta1-THC when compared with ethanol. 4 It was concluded that delta1-THC in concentrations up to 20 microgram/ml had negligible effect on contractile performance, the time course of contraction or muscle elasticity in rat and cat isolated papillary muscle preparations under the conditions studied.
D000818:Animals; D002415:Cats; D013759:Dronabinol / Q000494:pharmacology*; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D010210:Papillary Muscles / Q000187:drug effects; D051381:Rats
D013759:Dronabinol