Serum inhibitors to granulopoiesis in thalassemia major.
Peripheral blood (pb) and bone marrow CFU-C were evaluated in patients with thalassemia major. A decrease in both pb and marrow CFU-C was noted when compared to normal donors and individuals with hemolytic anemia requiring transfusion therapy. Experiments suggested that a nondialyzable serum factor was resonsible for the depressed pb CFU-C in 6 and of 6 children with thalassemia. Serum lipoprotein electrophoresis revealed type IV pattern in 9 out of 18 children with elevation of the pre-beta fraction. These experiments suggest (1) decreased stem cell CFU-C, (2) decreased pb CFU-C, and (3) a serum inhibitor that may be contributing to the depressed pb CFU-C.
D000293:Adolescent; D000328:Adult; D001854:Bone Marrow Cells; D002648:Child; D002675:Child, Preschool; D002999:Clone Cells; D006098:Granulocytes; D006410:Hematopoiesis; D006801:Humans; D007958:Leukocyte Count; D007962:Leukocytes; D008074:Lipoproteins / Q000097:blood; D013789:Thalassemia / Q000097:blood*
D008074:Lipoproteins