The influence of chlorpromazine, diazepam and imipramine on the central action of ethanol.
In experiments with white rats, chlorpromazine, diazepam and imirpramine injected intraperitoneally in the dose of 20 mg/kg and imipramine and diazepam in the dose of 50 mg/kg did not enhance the acute toxicity of ethanol expressed as LD50. Only chlorpromazine in the dose of 50 mg/kg i.p. increased toxicity of ethanol. However, the aforementioned drugs intensified the central action of ethanol by prolonging (except imipramine) duration of narcotic sleep and motor incoordination, and potential ethanol-induced hypothermia.
D000818:Animals; D002746:Chlorpromazine / Q000494:pharmacology*; D003975:Diazepam / Q000494:pharmacology*; D004357:Drug Synergism; D000431:Ethanol / Q000633:toxicity*; D007035:Hypothermia / Q000139:chemically induced; D007099:Imipramine / Q000494:pharmacology*; D007928:Lethal Dose 50; D008297:Male; D051381:Rats; D012890:Sleep / Q000187:drug effects
D000431:Ethanol; D007099:Imipramine; D003975:Diazepam; D002746:Chlorpromazine