Biotin as a regulator of some haematic parameters and of DNA-content of the liver of old rats.
Biotin administration to old rats (28 months) causes in the blood an increase of ATP, glucose, triglycerides, alkaline phosphatase and a decrease of cholesterol and acid phosphatase; in the liver DNA and electrostatic interactions between DNA and histones are increased. Such parameters come within the values shown by adult rats.
D000135:Acid Phosphatase / Q000097:blood; D000255:Adenosine Triphosphate / Q000097:blood; D000375:Aging; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001710:Biotin / Q000494:pharmacology*; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism; D001798:Blood Proteins / Q000032:analysis / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D004247:DNA / Q000032:analysis* / Q000378:metabolism; D003852:Deoxyribonucleoproteins / Q000032:analysis / Q000378:metabolism; D005260:Female; D008055:Lipids / Q000097:blood; D008099:Liver / Q000032:analysis / Q000187:drug effects* / Q000378:metabolism; D008660:Metabolism / Q000187:drug effects*; D051381:Rats; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D001798:Blood Proteins; D003852:Deoxyribonucleoproteins; D008055:Lipids; D014280:Triglycerides; D001710:Biotin; D000255:Adenosine Triphosphate; D004247:DNA; D002784:Cholesterol; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase