USP dissolution test II: Sigmoid dissolution profiles from directly compressed tablets.
The basic steps involved in the dissolution of a directly compressed tablet in a USP basket dissolution apparatus were examined via data generation. The proposed model explains why a dissolution curve can be sigmoid shaped and why the portion past the lag time has a log-linear undissolved mass versus time correlation.
D008956:Models, Chemical; D012995:Solubility; D013607:Tablets; D013997:Time Factors
D013607:Tablets