The effect of furosemide and bumetanide on warfarin metabolism and anticoagulant response.
In a study of 11 normal subjects who received either furosemide or bumetanide, response to warfarin was unaffected by either diuretic. The mean prothrombin times after a single oral dose of 50 mg warfarin were 18.8 +/- 0.7 sec before and 19.6 +/- 1.7 sec during furosemide administration, and 18.3 +/- 1.4 sec before and 19.7 +/- 1.3 sec during bumetanide administration. Mean plasma warfarin half-lives were 43.2 +/- 2.8 hr before and 37.8 +/- 1.7 hr during furosemide treatment and 39.9 +/- 9.5 hr before and 37.4 +/- 2.4 hr during bumetanide treatment. Hypoprothrombinemic responses, plasma warfarin concentrations, and warfarin half-lives were not significantly influenced by treatment with either diuretic. Both loop diuretics furosemide and bumetanide can be safely administered during warfarin anticoagulant therapy without risk of clinically significant interaction.
D000293:Adolescent; D000328:Adult; D001777:Blood Coagulation / Q000187:drug effects*; D002034:Bumetanide / Q000494:pharmacology*; D004232:Diuretics / Q000494:pharmacology*; D004311:Double-Blind Method; D004347:Drug Interactions; D005665:Furosemide / Q000494:pharmacology*; D006207:Half-Life; D006801:Humans; D008297:Male; D011517:Prothrombin Time; D014859:Warfarin / Q000097:blood / Q000494:pharmacology*
D004232:Diuretics; D002034:Bumetanide; D014859:Warfarin; D005665:Furosemide