Anticore antibody screening of transfused blood.
Aliquots of 130 HB8Ag negative units of blood which were administered to 26 recipients were tested under code for anti-HBc by a solid phase radioimmunoassay technqiue. 14 of the 26 recipients developed posttransfusion hepatitis (PTH), including 6 cases of hepatitis B. Anti-HBc was detected in 7 or 5.3% of 130 donor units. Of the 14 patients acquiring PTH, 6 received a unit of anti-HBc-positive blood. Type B hepatitis occurred in 4 of the 7 anti-HBc recipients, and non-type B hepatitis in 2. Only 1 of 12 recipients who failed to develop PTH had received a unit containing anti-HBc.
D000914:Antibodies, Viral / Q000302:isolation & purification*; D000918:Antibody Specificity; D001782:Blood Donors; D001803:Blood Transfusion; D002353:Carrier State; D006509:Hepatitis B / Q000517:prevention & control; D006510:Hepatitis B Antibodies / Q000302:isolation & purification*; D006512:Hepatitis B Core Antigens; D006801:Humans; D011863:Radioimmunoassay
D000914:Antibodies, Viral; D006510:Hepatitis B Antibodies; D006512:Hepatitis B Core Antigens