Tissue blood exchange and tissue oxygen tension in relation to total body oxygen consumption in experimental surgical shock.
This experimental shock model was well defined by the marked decrease in total body oxygen consumption, muscle PO2 and diffusion capacity during shock. Infusion of large amounts of electrolyte solution did not lead to a restoration of muscle oxygen tension after 1-4 hours. Dextran 40 infusion however restored both local PO2 and blood flow in the muscle as well as total body oxygen consumption.
D000818:Animals; D001692:Biological Transport; D003911:Dextrans / Q000494:pharmacology; D004285:Dogs; D008833:Microcirculation / Q000187:drug effects; D008954:Models, Biological; D009132:Muscles / Q000098:blood supply; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption; D012039:Regional Blood Flow; D012773:Shock, Surgical / Q000378:metabolism*
D003911:Dextrans; D010100:Oxygen