Analgesic and tranquilizing activity of 5,8-disubstituted 2-aminomethyl-3,4-dihydronaphthalenes.
Interesting analgesic activity approaching that of meperidine and codeine was observed in standard animal models for 8-chloro-3,4-dihydro-5-methoxy-2-pyrrolidinomethylnaphthalene (compound 7). This compound was orally effective and its analgesic activity was not reversed by the opiate antagonist, naloxone. A limited number of other 2-aminomethyl analogues displayed activity in neuroleptic screens.
D000700:Analgesics / Q000138:chemical synthesis; D000818:Animals; D004285:Dogs; D008297:Male; D051379:Mice; D009281:Naphthalenes / Q000138:chemical synthesis / Q000494:pharmacology*; D011759:Pyrrolidines / Q000138:chemical synthesis / Q000494:pharmacology; D051381:Rats; D014149:Tranquilizing Agents
D000700:Analgesics; D009281:Naphthalenes; D011759:Pyrrolidines; D014149:Tranquilizing Agents