Adenosine as a prostaglandin antagonist. Possible mechanism of the defect in combined immunodeficiency disease due to adenosine deaminase deficiency.
Adenosine inhibition of cell division in EB-virus-transformed human lymphocytes and in normal lymphocytes stimulated by phytohemagglutinin can be overcome by prostaglandin (PG) E2. Analysis of adenosine/PGE2 interactions in smooth muscle suggests that adenosine causes immuno-deficiency by blocking a PG-dependent calcium stage of lymphocyte activation.
D000241:Adenosine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000243:Adenosine Deaminase / Q000172:deficiency; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000201:enzymology; D037102:Lectins / Q000494:pharmacology; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male; D011458:Prostaglandins E / Q000037:antagonists & inhibitors* / Q000494:pharmacology
D037102:Lectins; D011458:Prostaglandins E; D000243:Adenosine Deaminase; D000241:Adenosine