[Physiopathology of articular chondrocalcinosis].
The physiopathological mechanisms leading to precipitation of pyrophosphate in the articular cartilage remain unclear. Numerous findings suggest an error in pyrophosphate metabolism: excessive production or defective degradation, a primary modification of the fundamental substance leading to crystallization, a chondrocyte dysfunction being a possible cause of these two anomalies. The relationships between deposition of calcium pyrophosphate and changes in the subchondral osseous plaque common to several metabolic diseases are even more mysterious.
D002131:Calcium Pyrophosphate / Q000378:metabolism; D002358:Cartilage, Articular / Q000378:metabolism; D002805:Chondrocalcinosis / Q000378:metabolism / Q000503:physiopathology*; D003460:Crystallization; D006801:Humans; D010587:Phagocytosis
D002131:Calcium Pyrophosphate
Physiopathologie de la chondrocalcinose articulaire.