Different effects of synthetic delta 9-tetrahydrocannabinol and cannabis extract on steroid metabolism in male rats.
Repeated oral administration of cannabis extract as well as synthetic delta9-tetrahydrocannabinol to male rats produced significant changes in excretion of androgenic steroids and their metabolites as detectable in blood and urine. Cannabis extracts were found to be significantly more active than the mixtures containing same amounts of synthetic cannabinoids.
D000728:Androgens / Q000378:metabolism*; D000737:Androstenols / Q000097:blood / Q000652:urine; D000818:Animals; D002186:Cannabinoids / Q000008:administration & dosage / Q000494:pharmacology*; D002188:Cannabis; D013759:Dronabinol / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051381:Rats; D013739:Testosterone / Q000097:blood / Q000652:urine
D000728:Androgens; D000737:Androstenols; D002186:Cannabinoids; D013739:Testosterone; D013759:Dronabinol