Keratan sulfate-like glycosaminoglycan in the cerebral cortex of the brain and its variation with age.
A keratan sulfate-like substance was found kn the cerebral cortex proteoglycans of rats. This substance tripled during the rapid growth phase from 1 to 3 months of age and then decreased steadily to a negligible quantity in the senescent rat, aged 25 months. In contrast, the uronic acid-containing glycosaminoglycans remained constant during the life span studied. The marked decrease observed in the proportion of keratan sulfate-like moiety to the other glycosaminoglycans in the cerebral cortex of the senescent rat (aged 25 months) compared with the young adult rat (aged 3 months) may explain the reduced extracellular volume observed by others in the senescent brain.
D000375:Aging; D000818:Animals; D050260:Carbohydrate Metabolism; D002540:Cerebral Cortex / Q000254:growth & development / Q000378:metabolism*; D006025:Glycosaminoglycans / Q000378:metabolism*; D007632:Keratan Sulfate / Q000378:metabolism; D008297:Male; D011509:Proteoglycans / Q000378:metabolism; D051381:Rats; D014574:Uronic Acids / Q000378:metabolism
D006025:Glycosaminoglycans; D011509:Proteoglycans; D014574:Uronic Acids; D007632:Keratan Sulfate