The inhibitory effect of crinofizin (pineal peptide extract) on adrenalin-induced hyperglycemia in rabbits.
The effect of crinofizin--a pineal peptide extract with clinical use--on adrenalin hyperglycemia was tested in the rabbit. Administered subcutaneously one hour before an i.v. hyperglycemic dose of adrenalin, crinofizin significantly reduced the hyperglycemic effect of this hormone. The results reveal the functional antagonism between adrenalin and hypoglycemic pineal peptide(s) called "pinealine".
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004837:Epinephrine / Q000494:pharmacology*; D006943:Hyperglycemia / Q000097:blood* / Q000139:chemically induced; D007700:Kinetics; D008297:Male; D010455:Peptides / Q000494:pharmacology*; D010870:Pineal Gland / Q000502:physiology*; D011817:Rabbits
D001786:Blood Glucose; D010455:Peptides; C016320:polypeptide pineal extract; D004837:Epinephrine