Disposition of sulfonamides in food-producing animals: pharmacokinetics of sulfathiazole in swine.
Disposition of sulfathiazole in plasma and urine of swine was determined following single intravenous and oral doses. Pharmacokinetics of the drug were described by a 1-compartment open model. The drug was rapidly eliminated, mainly by renal excretion of unchanged sulfathiazole and metabolism to acetylsulfathiazole, with a biological half-life of 1.4 hours. Sulfathiazole (in solution) was absorbed rapidly (half-life 0.8 hour) and relatively completely (73%) following oral administration.
D000818:Animals; D005260:Female; D013432:Sulfathiazoles / Q000097:blood / Q000378:metabolism* / Q000652:urine; D013552:Swine / Q000378:metabolism*
D013432:Sulfathiazoles