Topical treatment of vaccinia virus infection with an interferon inducer in rabbits.
Ointment containing 1.7 mg/g of the interferon inducer poly (ICLC) (a complex of polyriboinosinic-polyribocytidylic acid and with poly-L-lysine and carboxymethylcellulose) was effective both prophylactically and therapeutically against vaccinia virus infection in rabbit skin. Poly (ICLC)-treated animals developed higher titers of local interferon and of circulating virus-neutralizing antibodies than placebo-treated animals. Serum levels of greater than 100 units of interferon/ml were found 24 hr after application of the poly (ICLC) ointment to the skin of uninfected rabbits.
D000287:Administration, Topical; D000818:Animals; D002266:Carboxymethylcellulose Sodium / Q000627:therapeutic use; D007369:Interferon Inducers / Q000627:therapeutic use*; D007372:Interferons / Q000096:biosynthesis; D010919:Placebos; D011070:Poly I-C / Q000627:therapeutic use; D011107:Polylysine / Q000627:therapeutic use; D011817:Rabbits; D014615:Vaccinia / Q000517:prevention & control / Q000628:therapy*
D007369:Interferon Inducers; D010919:Placebos; D011107:Polylysine; D007372:Interferons; D002266:Carboxymethylcellulose Sodium; D011070:Poly I-C