The interrelations of gastrin release, antral gastrin concentration and acid secretion rate.
The interrelations of meal stimulated gastrin release, antral gastrin concentration (AGC) and acid secretion rate were examined in a heterogenous group of 72 patients, Gastrin release calculated as the integrated gastrin output was directly related to AGC, r = 0.50 (p less than 0.001) and inversely related to maximum acid output (MAO), r = -0.31 (p less than 0.01). The relation between integrated gastrin output and AGC was significant in 21 patients with low acid secretion rates (MAO: less than 10 mEq/h), r = 0.66 (p less than 0.01) and in 27 patients with normal acid secretion rates (MAO: 10-25 mEq/h), r = 0.56 (p less than 0.05), but not in 24 patients with high acid secretion rates (MAO: greater than 25 mEq/h), r= 0.35 (p greater than 0.05). A weak inverse relation between AGC and MAO may exist in patients with low acid secretion  rates, r = -0.40 (p less than 0.10). Considered together using multiple regression procedures AGC and MAO explained less than one-half of the variability in meal stimulated gastrin release.
D005502:Food; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000032:analysis; D005755:Gastrins / Q000032:analysis / Q000378:metabolism*; D005767:Gastrointestinal Diseases / Q000503:physiopathology; D006801:Humans; D011706:Pyloric Antrum / Q000032:analysis; D012636:Secretory Rate
D005755:Gastrins