[Mode of action of D-penicillamine in chronic polyarthritis. 1. Protein synthesis inhibition in synovial fluid cells].
The influence of D-Penicillamine on protein synthesis in synovial fluid cells was investigated in 5 patients suffering from rheumatoid arthritis. Intra-articular injection of this substance at a dosage of 5 to 250 mg is followed by an inhibition of protein synthesis in the synovial fluid cells.
D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D002908:Chronic Disease; D003864:Depression, Chemical; D006801:Humans; D007719:Knee Joint; D010396:Penicillamine / Q000494:pharmacology / Q000627:therapeutic use*; D014176:Protein Biosynthesis; D013582:Synovial Fluid / Q000166:cytology* / Q000378:metabolism
D010396:Penicillamine
Uber den Wirkungsmechanismus von D-Penicillamin bei chronischer Polyarthritis. 1. Proteinsynthesehemmung in Zellen der Synovialflüssigkeit.