The effect of vitamin supplementation upon antipyrine metabolism in the elderly.
1 Antipyrine plasma half-life and clearance rates were studied in 19 elderly patients shortly after admission to a geriatric ward and again 2 weeks after a course of dietary supplementation with Vitamins A, B complex, C and D. 2 Antipyrine half-life fell and clearance increased in the nine who had sub-clinical evidence of ascorbic acid deficiency. No correlation was found with other indices of nutritional status. 3 Vitamin supplementation in elderly people with no demonstrable deficiencies did not alter the metabolism of antipyrine.
D000368:Aged; D000983:Antipyrine / Q000097:blood*; D001205:Ascorbic Acid / Q000097:blood; D001206:Ascorbic Acid Deficiency; D001361:Avitaminosis / Q000097:blood*; D001798:Blood Proteins / Q000032:analysis; D006801:Humans; D007700:Kinetics; D007962:Leukocytes / Q000032:analysis; D014508:Urea / Q000097:blood; D014801:Vitamin A / Q000097:blood; D014815:Vitamins / Q000494:pharmacology*
D001798:Blood Proteins; D014815:Vitamins; D014801:Vitamin A; D014508:Urea; D001205:Ascorbic Acid; D000983:Antipyrine