Transient and long-term differential modulations of branched-chain alpha-keto acid decarboxylase activity in hypophysectomized rats.
Hypophysectomy caused a marked but transient increase in branched-chain alpha-keto acid decarboxylase activities in rat liver mitochondria, peaking at about nine days post-surgery. The magnitude of increase is different for each of the three branched-chain alpha-keto acids. The activities then fall to a new steady state in three weeks with alpha-ketoisovalerate decarboxylase activity within the normal range, alpha-keto-beta-methylvalerate decarboxylase activity at twice normal, and alpha-ketoisocaproate decarboxylase activity decreased to a level too low for accurate measurements.
D000818:Animals; D002208:Caproates / Q000378:metabolism; D002262:Carboxy-Lyases / Q000378:metabolism*; D045782:Hemiterpenes; D007016:Hypophysectomy; D007651:Keto Acids / Q000378:metabolism; D007656:Ketoglutaric Acids / Q000378:metabolism; D008930:Mitochondria, Liver / Q000201:enzymology; D010421:Pentanoic Acids / Q000378:metabolism; D051381:Rats
D002208:Caproates; D045782:Hemiterpenes; D007651:Keto Acids; D007656:Ketoglutaric Acids; D010421:Pentanoic Acids; C016211:alpha-keto-beta-methylvaleric acid; C001505:alpha-ketoisovalerate; C013082:alpha-ketoisocaproic acid; D002262:Carboxy-Lyases