Opsonic activity of guinea pig serum is reduced by in vivo administration of carcinogenic nitrosamines.
The administration of each of four carcinogenic nitrosamines to normal guinea pigs resulted in decreased opsonic activity of their sera but did not affect the capacity of their peritoneal macrophages to phagocytize particles opsonized with normal serum. Diphenylnitrosamine, a noncarcinogenic analogue, had no significant effect on opsonic or phagocytic activity.
D000818:Animals; D002273:Carcinogens / Q000494:pharmacology*; D003176:Complement C3 / Q000378:metabolism; D003181:Complement C4 / Q000378:metabolism; D011415:Complement Factor B / Q000378:metabolism; D003165:Complement System Proteins; D005260:Female; D006168:Guinea Pigs; D008297:Male; D009602:Nitrosamines / Q000494:pharmacology*; D009895:Opsonin Proteins; D010587:Phagocytosis
D002273:Carcinogens; D003176:Complement C3; D003181:Complement C4; D009602:Nitrosamines; D009895:Opsonin Proteins; D003165:Complement System Proteins; D011415:Complement Factor B