Comparative effects of dihydroergotoxine (DHET) on CBF and metabolism changes produced by experimental cerebral edema, hypoxia and hypertension.
Dihydroergotoxine (DHET) perfused in the dog (100 microgram/kg) presenting a cerebral per-hypocapno-anemic syndrome reduces cerebral hyperemia, increases cerebral venous PO2, despite the rise in CMRO2 and favors glucose oxidation by the brain. DHET (20 mg/kg p.o.) is able to drop mean, diastolic and systolic arterial blood pressures in renal-hypertensive rats having a cerebral edema induced by triethyltin intoxication without affecting cerebral water and sodium levels which are increased in the controls. DHET (50 microgram/kg i.v.) can also improve EEG changes produced by a traumatic edema but does not exert (200 microgram/kg i.v.) any effect on EEG changes produced in the rabbit by lithium chloride intoxication.
D000740:Anemia / Q000378:metabolism; D000818:Animals; D001784:Blood Gas Analysis; D001786:Blood Glucose / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D001929:Brain Edema / Q000378:metabolism*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004088:Dihydroergotoxine / Q000494:pharmacology*; D004195:Disease Models, Animal; D004285:Dogs; D004569:Electroencephalography; D004573:Electrolytes / Q000378:metabolism; D006977:Hypertension, Renal / Q000139:chemically induced / Q000378:metabolism*; D006985:Hyperventilation / Q000378:metabolism; D002534:Hypoxia, Brain / Q000378:metabolism*; D007773:Lactates / Q000378:metabolism; D008094:Lithium / Q000633:toxicity; D010101:Oxygen Consumption / Q000187:drug effects; D011817:Rabbits; D014267:Triethyltin Compounds / Q000633:toxicity
D001786:Blood Glucose; D004573:Electrolytes; D007773:Lactates; D014267:Triethyltin Compounds; D004088:Dihydroergotoxine; D008094:Lithium