Polymer-bound carbonic anhydrides in N-acylation of 7-aminocephalosporanic acid.
Aminocephalosporanic acid tert-butyl ester was reacted with polystyrene-bound mixed carbonic-carboxylic anhydrides to give the corresponding N-acylated derivatives. Clevage of the tert-butyl protecting group with trifluoroacetic acid gave the corresponding cephalosporanic acid.
D002245:Carbon Dioxide / Q000031:analogs & derivatives*; D002511:Cephalosporins / Q000138:chemical synthesis*; D008722:Methods; D011108:Polymers
D002511:Cephalosporins; D011108:Polymers; D002245:Carbon Dioxide