Effects of dietary constituents on ultraviolet light-mediated carcinogenesis.
The effects of several dietary supplements of antioxidants and enzyme inducers on ultraviolet light-mediated carcinogenesis were investigated. Glutathione (reduced) was without effect, but butylated hydroxytoluene, phenobarbital, and disulfiram all significantly suppressed the initiation and development of actinic lesions and tumors. On the basis of the present study and related previous ones, tumor inhibition appears to be due not to an umbrageous effect but rather to the induction of systemic physiological responses.
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D004032:Diet; D004221:Disulfiram / Q000494:pharmacology; D005260:Female; D005978:Glutathione / Q000494:pharmacology; D007642:Keratosis / Q000517:prevention & control; D051379:Mice; D008819:Mice, Nude; D009374:Neoplasms, Experimental / Q000517:prevention & control; D009381:Neoplasms, Radiation-Induced / Q000517:prevention & control*; D010634:Phenobarbital / Q000494:pharmacology; D011833:Radiation Injuries, Experimental / Q000517:prevention & control; D012878:Skin Neoplasms / Q000517:prevention & control*; D014466:Ultraviolet Rays
D000975:Antioxidants; D002084:Butylated Hydroxytoluene; D005978:Glutathione; D004221:Disulfiram; D010634:Phenobarbital