Removal of gastrin by various organs in dogs.
In 6 anesthetized dogs receiving 400 pmoles kg-1 hr-1 of natural human little gastrin intravenously, blood samples for radioimmunoassay of gastrin were taken repeatedly from a carotid artery, jugular vein, femoral vein, renal vein, and mesenteric vein. The calculated removal of gastrin in a single passage through these four vascular beds ranged from 21 to 30% and did not differ significantly among them. In 6 additional dogs, the carotid arterial to hepatic venous removal was 40%. We conclude that the percentage removal of gastrin is about the same in all of the major vascular beds of the body.
D000818:Animals; D004285:Dogs; D005268:Femoral Vein; D005755:Gastrins / Q000097:blood*; D006503:Hepatic Veins; D007422:Intestines / Q000502:physiology*; D007601:Jugular Veins; D007668:Kidney / Q000502:physiology*; D008099:Liver / Q000502:physiology*; D008642:Mesenteric Veins; D012082:Renal Veins
D005755:Gastrins