[Stimulating action of hematoporphyrin on motor coordination and resistance to fatigue in rats].
The pharmacological activity of hematoporphyrin has been studied on two experimental models which are able to monitor the motor coordination in the rat, namely the natatory exhaustion and the Rota-Rod tests. A dose related effect of hematoporphyrin in increasing resistane to motor fatigue has been observed in the Rota-Rod between 2-8 mg/kg i.p. Higher doses of hematoporphyrin seem to be less effective (difasic effect). In both tests hematoporphyrin was able to potentiate the stimulating effect of d-amphetamine (6 mg/kg s.c.). The potentiation appeared to be dose related between 2 and 8 mg/kg in the Rota Rod and between 2 and 16 mg/kg in the natatory test.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003913:Dextroamphetamine / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D005221:Fatigue / Q000517:prevention & control*; D006415:Hematoporphyrins / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats
D006415:Hematoporphyrins; D003913:Dextroamphetamine
Azione stimolante dell'ematoporfirina sul coordinamento motorio e sulla resistenza alla fatica nel ratto.