The effect of lithium on the increase in forebrain 5-hydroxyindoleacetic acid produced by raphe stimulation.
1 The change in forebrain 5-hydroxyindoleacetic acid (5-HIAA) concentration induced by raphe stimulation has been studied in rats treated with Li+ or 0.9% w/v NaCl solution (saline) for 10 days. 2 Raphe stimulation increased the forebrain concentration of 5-HIAA in both groups of animals. Chlorimipramine abolished this effect in the control group, but not in the Li+ group. 3 The inhibition of 5-hydroxytryptamine (5-HT) uptake by chlorimipramine was not affected by pretreatment with Li+ or by the addition of Li+ to synaptosomal suspensions in vitro. 4 It is suggested that the production of 5-HIAA following raphe stimulation in Li+-treated animals is derived from the metabolism of 5-HT which remains within the intracellular environment. The consequence of this in relation to transmitter release is discussed.
D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000648:ultrastructure; D001933:Brain Stem / Q000502:physiology*; D002997:Clomipramine / Q000494:pharmacology; D004558:Electric Stimulation; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism*; D066298:In Vitro Techniques; D008094:Lithium / Q000378:metabolism / Q000494:pharmacology*; D008297:Male; D011903:Raphe Nuclei / Q000502:physiology*; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D013574:Synaptosomes / Q000378:metabolism
D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D008094:Lithium; D002997:Clomipramine