7,N,N-Trimethyltryptamine: a selective inhibitor of synaptosomal serotonin uptake.
7,N,N-Trimethyltryptamine (TMT) was synthesized and evaluated as an inhibitor of synaptosomal biogenic amine uptake in rat forebrain homogenates. In addition to inhibiting 3H-serotonin uptake (IC50 = 0.4 micrometer), TMT appears to be quite selective and is much less potent in blocking either 3H-norepinephrine or 3H-dopamine uptake (IC50 = 180 micrometer and 61 micrometer, respectively).
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001921:Brain / Q000378:metabolism / Q000648:ultrastructure; D003864:Depression, Chemical; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism*; D014363:Tryptamines / Q000494:pharmacology*
D014363:Tryptamines; D012701:Serotonin