[Differences in the inductive effect of small doses of phenobarbital in rats depending on their age and sex].
The induction influence from low doses of phenobarbital introduced for 3 days (10, 10 and 20 mg/kg) on the detoxication rate of hexanal (100 mg/kg) in mongrel rats of different sexes and age was studied. Investigations included measurements of the protein, phospholipids and glycogen content in the liver and the use of continued lateral position time test. A three-day phenobarbital pre-treatment speeded up the hexenal detoxication in rats of all the age groups except the oldest ones (26--32 months). The acceleration as against controls was more spectacular in younger rats and sexually mature female rats (by comparison with sexually mature male rats). As contrasted to controls, a three-day administration of phenobarbital produced in test animals a rise of protein, phospholipids and glycogen content in the liver.
D000367:Age Factors; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D006591:Hexobarbital / Q000494:pharmacology; D008658:Inactivation, Metabolic; D008124:Locomotion / Q000187:drug effects; D008297:Male; D010634:Phenobarbital / Q000008:administration & dosage*; D011187:Posture; D051381:Rats; D012737:Sex Factors; D013997:Time Factors
D006591:Hexobarbital; D010634:Phenobarbital
Razlichiia induktsionnogo éffekta malykh doz fenobarbitala u krys v zavisimosti ot vozrasta i pola.