Inhibition of noradrenaline release from sympathetic nerves by pentobarbital.
Pentobarbital concentrations of 10--100 micrometer selectively inhibited the noradrenaline release evoked by activation of the nicotinic receptors on the terminals sympathetic nerves of the rabbit heart. Higher concentrations also decreased the noradrenaline release induced by KCl or by electrical stimulation of the nerve axons.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D004558:Electric Stimulation; D006329:Heart Conduction System / Q000187:drug effects*; D009638:Norepinephrine / Q000378:metabolism*; D010424:Pentobarbital / Q000494:pharmacology*; D011817:Rabbits; D011950:Receptors, Cholinergic / Q000187:drug effects*; D011978:Receptors, Nicotinic / Q000187:drug effects*
D011950:Receptors, Cholinergic; D011978:Receptors, Nicotinic; D010424:Pentobarbital; D000109:Acetylcholine; D009638:Norepinephrine