Pepstatin- and leupeptin-loaded liposomes: a tool in protein breakdown studies.
The preparation of proteinase inhibitor loaded "solid" positively charged liposomes is described. Some properties of the vesicle preparations are given and the findings are tentatively summarized in a scheme of liposomophagy.
D000818:Animals; D002784:Cholesterol; D007976:Leupeptins / Q000494:pharmacology; D008081:Liposomes; D008247:Lysosomes / Q000187:drug effects / Q000378:metabolism*; D008954:Models, Biological; D009842:Oligopeptides / Q000494:pharmacology; D010436:Pepstatins / Q000494:pharmacology; D010713:Phosphatidylcholines; D011506:Proteins / Q000378:metabolism*
D007976:Leupeptins; D008081:Liposomes; D009842:Oligopeptides; D010436:Pepstatins; D010713:Phosphatidylcholines; D011506:Proteins; D002784:Cholesterol