Persistent hypothalamic-pituitary insufficiency following acute meningoencephalitis. A report of two cases.
This report concerns two patients, a 43-year-old woman and a 53-year-old man, who developed clinical as well as laboratory signs of permanent gonodal and thyroid failure following an acute intracranial infection--in the woman a meningoencephalitis of unknown origin, and in the man an encephalitis caused by Coxsackie B5. Endocrine investigations were compatible with hypothalamic-pituitary dysfunction, with some of the results favoring a hypothalamic lesion. Perhaps hormone deficiency of hypothalamic and/or pituitary origin is a more common sequel of acute meningoencephalitis than has hitherto been reported.
D000208:Acute Disease; D000328:Adult; D003384:Coxsackievirus Infections / Q000150:complications*; D005260:Female; D006801:Humans; D007018:Hypopituitarism / Q000209:etiology*; D007031:Hypothalamus / Q000503:physiopathology*; D007037:Hypothyroidism / Q000209:etiology; D008297:Male; D008590:Meningoencephalitis / Q000150:complications*; D008875:Middle Aged; D010902:Pituitary Gland / Q000503:physiopathology; D010907:Pituitary Hormones / Q000097:blood; D013961:Thyroid Gland / Q000503:physiopathology; D013963:Thyroid Hormones / Q000097:blood
D010907:Pituitary Hormones; D013963:Thyroid Hormones