Dominant and recessive effects of induced-lethals in female mice by exposure to gamma-irradiation during the 10th to 14th day of intrauterine life.
The frequency of (dominant and) recessive lethal mutations induced by 160-rad chronic gamma-irradiation given with a dose rate of 0.03 rad/min during the 10th to 14th day of gestation has been studied in female CBA-mice. An increased rate of recessive lethal equivalents by about 10% has been noted. This increase corresponds to a mutation rate of 6.3 X 10(-4) mutation/rad/genome. There were not found any dominant mutations, nor any dominance effects from the induced recessive lethal equivalents. The hazards after irradiation during foetal development are discussed.
D000818:Animals; D005260:Female; D005333:Fetus / Q000528:radiation effects*; D005720:Gamma Rays; D005787:Gene Frequency; D005799:Genes, Dominant; D005804:Genes, Lethal; D005808:Genes, Recessive; D005865:Gestational Age; D051379:Mice; D008808:Mice, Inbred CBA; D010053:Ovary / Q000528:radiation effects*