Quantitative field desorption mass spectrometry. V. Discussion of methodology and examples of applications.
The possibilities for the application of field desorption mass spectrometry in quantitative analyses are described and evaluated. The advantages of and the sources of errors in the use of different standards as well as in the application of different methods such as photographic detection, single ion monitoring, repetitive scanning, selected ion monitoring, and double ion detection are illustrated by representative examples. Sensitivity and precision of the different techniques are evaluated. Most importantly, the use of stable isotope labelled compounds as internal standards has enabled quantitative determination with good precision, accuracy, and sensitivity. In order to demonstrate the capabilities of the methods, examples of applications are presented and the scope of quantitative analysis with field desorption mass spectrometry is discussed.
D006801:Humans; D013058:Mass Spectrometry / Q000295:instrumentation / Q000379:methods*; D010661:Phenylketonurias / Q000652:urine; D014443:Tyrosine / Q000652:urine
D014443:Tyrosine