Pressure-induced ischemia. II. A metabolic study in hamster cheek pouch.
The effects of pressure-induced ischemia on energy metabolism, measured as ATP and glucose content, is studied in hamster cheek pouch. Metabolic deterioration during ischaemia is studied and after 2 h the glucose content was significantly reduced but not the ATP content, which was significantly reduced after 4 h of ischemia. Restoration of glucose levels in the cheek pouch tissue was achieved within 30 min of recirculation after release of pressure. The cellular energy metabolism is unable after 4 h of ischemia to restore ATP levels in the tissue during the 120-min of postischemic observation time. There is a difference in ability to resume normal energy metabolism after 2 and 4 h of pressure-induced ischemia.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002610:Cheek; D006224:Cricetinae; D004734:Energy Metabolism; D005260:Female; D005947:Glucose / Q000378:metabolism; D007511:Ischemia / Q000209:etiology / Q000378:metabolism*; D008297:Male; D008647:Mesocricetus; D008833:Microcirculation; D011312:Pressure; D013997:Time Factors
D000255:Adenosine Triphosphate; D005947:Glucose