Half life of injected 125I-insulin in control and ob/ob mice.
The t-1/2 of moniodo 125I-insulin in ob/ob mice and their lean litter mates is 10 min. No difference was found between the two groups. Further, 48 hr of fasting did not alter the t-1/2 in ob/ob mice. In view of the markedly enlarged insulin pool in ob/ob mice, one must conclude that the mass of insulin degraded in unit time is increased. However, these findings indicate that the cause of hyperinsulinism in ob/ob mice is unrelated to rates of insulin degradation.
D000818:Animals; D001835:Body Weight; D005215:Fasting; D006207:Half-Life; D006946:Hyperinsulinism / Q000378:metabolism*; D007328:Insulin / Q000032:analysis / Q000378:metabolism*; D007457:Iodine Radioisotopes; D008433:Mathematics; D051379:Mice; D008810:Mice, Inbred C57BL; D051381:Rats; D013552:Swine
D007328:Insulin; D007457:Iodine Radioisotopes