[Mode of action of D-penicillamine in chronic polyarthritis. 2. Studies on DNA repair in synovial fluid cells following intra-articular administration of D-penicillamine].
6 patients with rheumatoid arthritis were treated intraarticularly with 50 or 100 mg D-Penicillamine. The influence of this substance on DNA repair in cells of synovial fluid was investigated. DNA repair was investigated by gradient centrifugation. 50 mg D-PA showed no effect, 100 mg D-PA a slight slowing of the DNA-rejoining till the native supercoiled DNA form.
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D002908:Chronic Disease; D004247:DNA / Q000528:radiation effects; D004260:DNA Repair / Q000187:drug effects; D005720:Gamma Rays; D006801:Humans; D007270:Injections, Intra-Articular; D007719:Knee Joint; D010396:Penicillamine / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D013582:Synovial Fluid / Q000166:cytology / Q000528:radiation effects
D004247:DNA; D010396:Penicillamine
Uber den Wirkungsmechanismus von D-Penicillamin bei chronischer Polyarthritis. 2. Untersuchungen über die DNA-Reparatur in Zellen der Synovialflüssigkeit nach intraartikulärer D-Penicillamin-Verabreichung.