The hemodynamic effect of halothane in the normovolemic dog.
With the aid of radioactive microspheres (labeled with 169Yb, 85Sr and 141Ce, respectively), the effect of halothane anesthesia on circulation was studied for 30 min and (group A) for 120 min of halothane anesthesia in thiopental-sedated dogs. Measurements were also carried out on recovery from halothane anesthesia. Besides such well-known general circulatory changes as reduction in cardiac output, pulse rate, left ventricular work, arterial mean blood pressure and left atrial mean blood pressure, in both groups there was also a reduced coronary blood flow. The flow to the lungs, kidneys and the brain was well preserved, despite the reduction in both the cardiac output and arterial mean blood pressure. The flow to the liver, however, did not change during short halothane anesthesia; but during long anesthesia there was a marked reduction, due mainly to a decrease in the flow to the preportal area. On recovery from halothane anesthesia, the changes had mostly returned to the preanesthetic values.
D000769:Anesthesia, Inhalation; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D006221:Halothane / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects*; D007668:Kidney / Q000098:blood supply; D008102:Liver Circulation / Q000187:drug effects; D008863:Microspheres; D011652:Pulmonary Circulation / Q000187:drug effects; D013997:Time Factors
D006221:Halothane