Normal distribution of acetylation phenotypes in systemic lupus erythematosus.
Previous reports have indicated that idiopathic systemic lupus erythematosus (SLE), like drug-induced lupus, is more frequent in "slow" hepatic acetylators. Using dapsone acetylation rate to determine phenotypes, we found that of the 18 SLE patients studied, 9 were fast acetylators, 8 were slow, and 1 was indeterminate. This result (53% fast) is similar to acetylator phenotypes in our normal controls (50% fast) and in the population at large (52%).
D000107:Acetylation; D000123:Acetyltransferases / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D002648:Child; D002853:Chromatography, Liquid; D003622:Dapsone / Q000031:analogs & derivatives / Q000378:metabolism; D005260:Female; D006801:Humans; D008099:Liver / Q000378:metabolism; D008180:Lupus Erythematosus, Systemic / Q000235:genetics / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D013997:Time Factors
D003622:Dapsone; D000123:Acetyltransferases