Folate-dependent serine synthesis in lymphocytes from controls and patients with megaloblastic anaemia: the effect of therapy.
The utilization of [14C]formate for serine synthesis by lymphocytes was impaired in all the patients with pernicious anaemia and in 70% of other patients with megaloblastic anaemia. In pernicious anaemia this was corrected by vitamin B12 therapy in 48 h but not by folate therapy although patients given folate showed a satisfactory haematological response.
D000748:Anemia, Macrocytic / Q000378:metabolism*; D000749:Anemia, Megaloblastic / Q000188:drug therapy / Q000378:metabolism*; D000752:Anemia, Pernicious / Q000378:metabolism; D005492:Folic Acid / Q000378:metabolism* / Q000627:therapeutic use; D005494:Folic Acid Deficiency / Q000378:metabolism; D005561:Formates / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000378:metabolism*; D012694:Serine / Q000096:biosynthesis*; D014805:Vitamin B 12 / Q000627:therapeutic use; D014806:Vitamin B 12 Deficiency / Q000378:metabolism
D005561:Formates; D012694:Serine; D005492:Folic Acid; D014805:Vitamin B 12