Appearance of interferon inducibility and sensitivity during differentiation of murine teratocarcinoma cells in vitro.
Pluripotential embryonal carcinoma (EC) cells do not produce interferon after treatment with a wide variety of inducers, nor are they sensitive to its action. Several differentiated lines derived from the EC cells, however, both produce and are sensitive to mouse interferon. Differentiation of EC cells in vitro is accompanied by development of interferon inducibility and sensitivity.
D002454:Cell Differentiation; D002455:Cell Division; D002460:Cell Line; D002999:Clone Cells; D007369:Interferon Inducers; D007372:Interferons / Q000096:biosynthesis* / Q000494:pharmacology; D009522:Newcastle disease virus / Q000254:growth & development; D012672:Semliki forest virus / Q000254:growth & development; D013724:Teratoma
D007369:Interferon Inducers; D007372:Interferons