The metabolism of lithocholic acid-3alpha-sulfate by human intestinal microflora.
Lithocholic acid-3alpha-sulfate is metabolized by human intestinal microflora to nonpolar metabolites which have been partially purified by Sephadex LH-20 chromatography. These metabolites were characterized by thin layer and gas liquid chromatography as well as combined gas liquid chromatography-mass spectrometry. The chromatographic properties of one of the metabolites are consistent with those described for a delta2- or delta3-cholenate. The formation of cholenates by the microflora may represent a retoxification of the sulfate ester of lithocholic acid.
D002770:Cholenes / Q000378:metabolism; D005243:Feces / Q000382:microbiology; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000382:microbiology*; D008095:Lithocholic Acid / Q000378:metabolism*; D013463:Sulfuric Acid Esters / Q000378:metabolism
D002770:Cholenes; D013463:Sulfuric Acid Esters; D008095:Lithocholic Acid