[Mutagenic action of cadmium on the sex cells of male mice].
Possible mutagenic effect of cadmium chloride was studied by determining the frequency of dominant lethal mutations induced in germ cells of male mice. Water solution of CdCl2 was injected intraperitoneally to male mice at doses of 1.0, 2.0 and 4.0 mg/kg. The results obtained did not reveal any mutagenic effect of this compound. The dose of 4.0 mg/kg CdCl2 resulted in the death of spermatocytes and spermatogonia and the sterility of male mice. Cadmium chloride at a dose of 2.0 mg/kg did not affect the frequency of dominant lethal mutation induced by gamma-rays 60Co at a dose of 450 r in germ cells of male mice.
D000818:Animals; D002104:Cadmium / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D020964:Embryo Loss / Q000139:chemically induced; D005260:Female; D005720:Gamma Rays / Q000009:adverse effects; D005799:Genes, Dominant / Q000187:drug effects; D005804:Genes, Lethal / Q000187:drug effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009153:Mutagens; D011247:Pregnancy; D013091:Spermatogenesis / Q000187:drug effects / Q000528:radiation effects; D013094:Spermatozoa / Q000187:drug effects* / Q000528:radiation effects
D009153:Mutagens; D002104:Cadmium
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