Antileukemic activity of ungeremine and related compounds. Preparation of analogues of ungeremine by a practical photochemical reaction.
A number of alkoxypyrrolophenanthridinium salts and their analogues related to the antileukemic alkaloid ungeremine were prepared by a practical photochemical cyclization. The importance of the quaternary nitrogen atom and of alkoxy groups, the planarity of a molecule, and steric considerations relative to antileukemic activity are discussed.
D000470:Alkaloids / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D047151:Amaryllidaceae Alkaloids; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000627:therapeutic use; D003500:Cyclization; D007212:Indolizines; D007942:Leukemia, Experimental / Q000188:drug therapy; D051379:Mice; D010777:Photochemistry; D013329:Structure-Activity Relationship
D000470:Alkaloids; D047151:Amaryllidaceae Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D007212:Indolizines; C016175:ungeremine