Cross reactivity of digitoxin and spironolactone in two radioimmunoassays for serum digoxin.
We measured the cross reactivity of two medications--digitoxin and spironolactone--in two digoxin radioimmunoassay (liquid and solid-phase) kit procedures. Both tests showed similar average percentages of cross reactivity with digitoxin (7.2 and 8.9% for intravenous, and 11.9 and 10.9% for oral administration), but no cross reactivity with spironolactone or its metabolites after equal intravenous or oral doses.
D003429:Cross Reactions; D004071:Digitalis Glycosides / Q000276:immunology*; D004072:Digitonin / Q000276:immunology*; D004077:Digoxin / Q000097:blood* / Q000276:immunology; D005069:Evaluation Studies as Topic; D006801:Humans; D008297:Male; D008722:Methods; D011863:Radioimmunoassay; D013148:Spironolactone / Q000276:immunology*
D004071:Digitalis Glycosides; D013148:Spironolactone; D004077:Digoxin; D004072:Digitonin