Convenient synthesis of (RS)-4-amino-3-hydroxybutyric acid.
A new three-step synthesis of 4-amino-3-hydroxybutyric acid from an inexpensive starting material and under mild reaction conditions is described. Crotonic acid was brominated by the Wohl-Ziegler reaction to 4-bromocrotonic acid, which, in turn, was converted with ammonium hydroxide into 4-aminocrotonic acid. This compound, refluxed in water in the presence of a strong acid resin, afforded 4 amino-3-hydroxybutyric acid in good yields.
D000613:Aminobutyrates / Q000138:chemical synthesis*; D003437:Crotonates; D006885:Hydroxybutyrates / Q000138:chemical synthesis*; D008722:Methods
D000613:Aminobutyrates; D003437:Crotonates; D006885:Hydroxybutyrates