The uri nary excretion of 2-phenylethylamine in phenylketonuria.
The urinary concentrations of free and conjugated 2-phenylethylamine were determined in phenylketonuric patients and normal subjects by solvent extraction and gas chromatography. Free 2-phenylethylamine excretion was found to be significantly elevated above normal in phenylketonuric adults and children receiving a normal or a slightly restricted intake of phenylalanine. Urinary 2-phenylethylamine was also significantly increased in phenylketonuric children receiving low phenylalaine dietary therapy. Conjugated 2-phenylethylamine excretion was found not to be increased above normal. In the light of these results, a relationship between blood phenylalanine concentration and 2-phenylethylamine excretion is proposed, and the possible role of this amine in phenylketonuria is discussed.
D000328:Adult; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D010627:Phenethylamines / Q000652:urine*; D010649:Phenylalanine / Q000097:blood / Q000627:therapeutic use; D010661:Phenylketonurias / Q000178:diet therapy / Q000652:urine*
D010627:Phenethylamines; D010649:Phenylalanine