Studies on the mechanism of reflex vasodilatation. The cholinergic component in the baroreceptorial reflex in the dog.
This study was designed to investigate whether the cholinergic system is involved in the genesis of the reflex vasodilatation which follows the systemic hypertension induced by fast intravenous injection of norepinephrine in the dog. Accordingly, in 7 dogs the gracilis muscle was isolated and perfused and the reflex evoked. The analysis of the integrated areas of vasodilatation after atropine pretreatment showed a significant decrease of the reflex response in the perfused circulation. In fact, the mean value of the integrated areas of vasodilatation which was 66 +/- 8 mm Hg/min in the control condition, was reduced to 45 +/- 4 mm Hg/min after administration of atropine in the gracilis artery; meanwhile the integrated areas of systemic hypertension did not show any change. Phentolamine intra-arterial administration completely abolished the reflex. These results suggest the existence of a cholinergic component in the reflex vasodilatation induced by transitory baroreceptorial stimulation.
D000818:Animals; D001285:Atropine / Q000008:administration & dosage / Q000494:pharmacology; D004285:Dogs; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D006973:Hypertension / Q000139:chemically induced; D007275:Injections, Intravenous; D008297:Male; D009132:Muscles / Q000098:blood supply; D009638:Norepinephrine / Q000008:administration & dosage / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D011311:Pressoreceptors / Q000502:physiology*; D011950:Receptors, Cholinergic / Q000187:drug effects / Q000502:physiology*; D012018:Reflex / Q000502:physiology*; D013997:Time Factors; D014664:Vasodilation / Q000187:drug effects
D011950:Receptors, Cholinergic; D001285:Atropine; D009638:Norepinephrine; D010646:Phentolamine