Increased ALA dehydratase activity and spleen weight in lead-intoxicated rats. A consequence of increased blood cell destruction.
Lead was given in the diet (1%) to rats from birth and at different times the animals were studies for delta amino levulinic acid dehydratase (ALAD) activity, spleen weight, 59Fe incorporation in erythrocytes and 51Cr-labeled erythrocytes survival. The increased ALAD and spleen weight found after lead treatment is explained as a consequence of a shortened survival, which results in a younger age of circulating erythrocytes with higher ALAD activity.
D000818:Animals; D004905:Erythrocyte Aging; D004912:Erythrocytes / Q000378:metabolism; D007501:Iron / Q000378:metabolism; D007855:Lead Poisoning / Q000097:blood / Q000201:enzymology*; D009929:Organ Size; D000623:Porphobilinogen Synthase / Q000097:blood* / Q000378:metabolism; D051381:Rats; D013154:Spleen
D007501:Iron; D000623:Porphobilinogen Synthase