[Role of sterol photoconversion products in the regulation of cholesterol biosynthesis in rat skin].
In order to clarify the effect of products of photochemical conversion of sterols on cholesterol biosynthesis, rat skin samples were incubated with 2-(14)C-acetate in the presence of the antirachitic agent Dk and 7beta-hydroxycholesterol. The synthesis of sterols from acetate was activated in the presence of Dk. A correlation between the activation of sterol synthesis and the concentration of the antirachitic agent was found. An addition of 7beta-hydroxycholesterol to the incubation medium inhibited acetate incorporation into the sterols. The level of synthesis inhibition increased with an elevation of the 7beta-hydroxysterol concentration in the incubation medium. This indicates that both products of sterol photoconversion can be involved in the control of cholesterol biosynthesis.
D000085:Acetates / Q000378:metabolism; D000818:Animals; D002784:Cholesterol / Q000096:biosynthesis*; D004305:Dose-Response Relationship, Drug; D006888:Hydroxycholesterols / Q000494:pharmacology*; D066298:In Vitro Techniques; D010777:Photochemistry; D051381:Rats; D012867:Skin / Q000187:drug effects* / Q000378:metabolism; D013261:Sterols / Q000494:pharmacology*
D000085:Acetates; D006888:Hydroxycholesterols; D013261:Sterols; D002784:Cholesterol
Rol' produktov fotoprevrashcheniia sterinov v reguliatsii biosinteza kholesterina v kozhe krys.