Lack of susceptibility of F344 rats to mammary tumor induction by topically applied fluorenylacetohydroxamic acids and their acetates.
Carcinogenicity of N-hydroxy-N-3-fluorenylacetamide for the mammary glands of female inbred F344 rats was examined after systemic and topical administration. The compound given ip produced a 60% mammary tumor incidence but was only marginally active after topical application. Female F344 rats did not develop mammary tumors after topical application of N-hydroxy-N-2-fluorenylacetamide, N-acetoxy-N-2-fluorenylacetamide, or N-acetoxy-N-3-fluorenylacetamide. These results contrasted with those reported earlier for female Sprague-Dawley rats and indicated differences in susceptibility of the mammary glands of these rat strains to tumor induction by these carcinogens.
D000099:Acetoxyacetylaminofluorene / Q000008:administration & dosage* / Q000378:metabolism / Q000633:toxicity; D000287:Administration, Topical; D000818:Animals; D001711:Biotransformation; D005260:Female; D005449:Fluorenes / Q000008:administration & dosage*; D006881:Hydroxyacetylaminofluorene / Q000008:administration & dosage* / Q000378:metabolism / Q000633:toxicity; D007274:Injections, Intraperitoneal; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced*; D051381:Rats; D011916:Rats, Inbred F344; D013045:Species Specificity
D005449:Fluorenes; D006881:Hydroxyacetylaminofluorene; D000099:Acetoxyacetylaminofluorene