Sodium and water metabolism under the influence of prolactin, aldosterone, and antidiuretic hormone.
1. Rabbits were placed in metabolism cages in order to measure their intakes of food, water, and sodium chloride (as 1% saline solution), and to measure urinary and faecal excretion of sodium, potassium, and water. 2. Antidiuretic hormone (0.2 i.u./day) caused a reduction in urine volume and no change in sodium excretion. There was full compensatory reduction in water intake so that no accumulation of water occurred. 3. Aldosterone (4 mg/da) caused a reduction in renal sodium excretion for 1--2 days. The saline intake was reduced, though this was insufficient to prevent some sodium accumulation. 4. Renal mineralocorticoid 'escape' resulted in a large increase in sodium excretion at the end of the aldosterone treatment period. This was fully compensated through increased saline intake, and balance was maintained. 5. Prolactin (200 i.u./day) caused a reduction in urine volume and in renal sodium excretion and since there were no compensatory changes in water and sodium intake, this led to substantial accumulation of both water and sodium. 6. The effects of smaller doses of both aldosterone and prolactin were investigated and found to be similar but smaller. 7. It is suggested that whereas prolactin may have little or no role to play in the sodium homoeostasis of the normal animal, the hormone may well be responsible for the substantial increase in body fluids in pregnancy.
D000450:Aldosterone / Q000494:pharmacology*; D000818:Animals; D001066:Appetite / Q000187:drug effects; D004326:Drinking / Q000187:drug effects; D009318:Natriuresis / Q000187:drug effects; D011188:Potassium / Q000097:blood; D011388:Prolactin / Q000494:pharmacology*; D011817:Rabbits; D012964:Sodium / Q000097:blood / Q000378:metabolism* / Q000652:urine; D014556:Urine / Q000032:analysis; D014667:Vasopressins / Q000494:pharmacology*; D014867:Water / Q000378:metabolism*
D014867:Water; D014667:Vasopressins; D000450:Aldosterone; D011388:Prolactin; D012964:Sodium; D011188:Potassium