The formation of cyclized silyl derivatives of beta-hydroxyamines and their analyses by means of gas chromatography mass spectrometry.
A generally applicable silylation method for beta-hydroxylated primary, secondary, tertiary and even quaternary amines is presented. These aminoalcohols form 6-membered heterocycles under the influence of a reagent mixture consisting of 1,3-bis-(chloromethyl)-1,1,3,3-tetramethyldisilazane and chloromethyldimethyl-chlorosilane. Examples of analogue ring closures with a gamma-hydroxyamine and an alpha-amino acid are also given. The formation of the derivatives and their properties, are discussed, mainly from the viewpoint mass spectrometry.
D000605:Amino Alcohols / Q000032:analysis*; D055598:Chemical Phenomena; D002621:Chemistry; D002849:Chromatography, Gas / Q000379:methods; D013058:Mass Spectrometry / Q000379:methods; D012821:Silanes
D000605:Amino Alcohols; D012821:Silanes