Lysine transfer RNA2 is the major target for L-ethionine in the rat.
Ethionine, a hepatocarcinogen, ethylates macromolecules in vivo especially tRNA of rat liver. When rats were injected with L-[ethyl-3H]ethionine, the tRNA fraction of the liver was found to be labeled. One tRNA with the highest specific activity was purified and identified as lysine-tRNA2.
D000818:Animals; D005001:Ethionine / Q000378:metabolism* / Q000494:pharmacology; D005260:Female; D008099:Liver / Q000378:metabolism*; D008239:Lysine; D008970:Molecular Weight; D009843:Oligoribonucleotides / Q000032:analysis; D012343:RNA, Transfer / Q000378:metabolism*; D051381:Rats
D009843:Oligoribonucleotides; D012343:RNA, Transfer; D008239:Lysine; D005001:Ethionine