[Acrodermatitis enteropathica. Anatomo-clinical study of 2 familial cases treated with zinc sulfate].
Two familial cases of acrodermatitis enteropathica began at the time of weaning, with characteristic dermatologic lesions and digestive signs, resulting in lack of weight gain: at 13 months of age growth future was evident in the elder child. The anatomic lesions were those of an exophagitis and, in the duodenal mucosa, a dilation of the capillaries of the chorion in the absence of villous atrophy. The ultrastructural study showed inclusions in Paneth's cells, and changes in keratin cells, with intra-cytoplasmic vacuoles and abnormal melanin pigment in the skin. The administration of zinc sulphate induced a rapid recovery of cutaneous lesions and resumption of growth. The interruption of treatment resulted twice in a quite immediate relapse of cutaneous signs in the first patient, which was rapidly reversible with the reintroduction of zinc sulphate.
D000169:Acrodermatitis / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D002196:Capillaries / Q000648:ultrastructure*; D002823:Chorion / Q000098:blood supply*; D004386:Duodenum / Q000648:ultrastructure*; D004817:Epidermis / Q000648:ultrastructure*; D004947:Esophagus / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D015032:Zinc / Q000627:therapeutic use*
D015032:Zinc
Acrodermatitis enteropathica. Etude anatomo-clinique de deux das familiaux traites par le sulfate de zinc.