[Effect of corticosteroids, androgens and their metabolites on the activation of lymphoid cells].
The character of hydrocortisone and testosterone, and also of their metabolites (cortisone and 5alpha-dihydrotestosterone) influence on the lymphocyte blasttransformation induced with PHA and various antigens was studied. Testosterone proved to produce a preponderant depressive action on the blasttransformation induced by PHA. On the contrary, hydrocortisone considerably suppressed the blasttransformation to the antigen. The suppressive influence on the blasttransformation to PHA is intensive in case of a simultaneous administration into the culture of the hormonal preparations and mitogen. Transformation of the hormones into metabolites is accompanied by some reduction of their suppressive influence on the blasttransformation. On the whole, blasttransformation to PHA is more resistant to the action of the hormones than that induced with the antigen.
D003348:Cortisone / Q000494:pharmacology*; D003864:Depression, Chemical; D013196:Dihydrotestosterone / Q000494:pharmacology*; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology*; D066298:In Vitro Techniques; D037102:Lectins / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000276:immunology*; D014066:Palatine Tonsil / Q000166:cytology; D013739:Testosterone / Q000494:pharmacology*
D037102:Lectins; D013196:Dihydrotestosterone; D013739:Testosterone; D003348:Cortisone; D006854:Hydrocortisone
Vliianie kortikosteroidov, androgenov i ikh metabolitov na aktivatsiiu limfoidnykh kletok.