Inhibition of dopamine release in the cat caudate nucleus by nigral application of glycine.
"Encéphale isolé" cats were implanted with two push-pull cannulae, one in the left caudate nucleus and the other in the ipsilateral substantia nigra. L-3,5(-3)H-Tyrosine was introduced continuously into the caudate nucleus to study the release of 3H-DA. Glycine (10(-5)M) added to the superfusing medium of the push-pull cannula inserted into the substantia nigra reduced (25%) the spontaneous release of 3H-DA. Conversely, strychnine (10(-5)M) slightly stimulated the 3H-transmitter release. The inhibiting effect of glycine (10(-5)M) on 3H-DA release was no longer seen in the presence of strychnine (10(-5) M). The results support the hypothesis of a tonic glycinergic inhibitory control of the activity of the nigrostriatal dopaminergic neurons.
D000818:Animals; D002415:Cats; D002421:Caudate Nucleus / Q000187:drug effects* / Q000378:metabolism; D003655:Decerebrate State; D003864:Depression, Chemical; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D005998:Glycine / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D008297:Male; D010477:Perfusion; D013331:Strychnine / Q000494:pharmacology; D013378:Substantia Nigra / Q000187:drug effects*
D013331:Strychnine; D005998:Glycine; D004298:Dopamine