HLA-B27 associated arthropathies.
The association between histo-compatibility antigens and disease is reviewed, in particular that between HLA-B27 and spondylitic disorders, i.e., ankylosing spondylitis, Reiter's arthritis, psoriatic arthritis, and ankylosing hyperostosis. We determined whether the presence of HLA-B27 predicted specific radiographic findings and, conversely, whether specific radiographic changes predicted antigenic status. The prevalences of the HLA-B27 antigen in our patients were: ankylosing spondylitis, 100%; Reiter's arthritis, 93%; psoriatic arthritis, 55%; and ankylosing hyperostosis, 12%. The only specific radiographic finding associated with B27 positivity was severe spondylitis in psoriasis.
D001168:Arthritis / Q000000981:diagnostic imaging* / Q000276:immunology; D016918:Arthritis, Reactive / Q000000981:diagnostic imaging / Q000276:immunology; D006680:HLA Antigens / Q000032:analysis*; D006801:Humans; D011565:Psoriasis / Q000000981:diagnostic imaging / Q000276:immunology; D011859:Radiography; D013128:Spinal Osteophytosis / Q000000981:diagnostic imaging / Q000276:immunology; D013167:Spondylitis, Ankylosing / Q000000981:diagnostic imaging / Q000276:immunology
D006680:HLA Antigens