[Effect of hypoxia and hyperthermia on the processes of lipid peroxidation in the rat liver against a background of the action of gutimine and unsaturated amines].
Following the action of extraordinary stimulants (hypoxic hypoxia, hypoxia+hyperoxia, hypodynamia+hyperthermy) animals demonstrate accumulation of malonic dialdehyde with a simultaneous fall of antiradical activity of the liver tissue. A preliminary introduction to rats of acetylene amines--1,4 bis (3-morpholinopropynyl) benzol 3,4,5-(morpholinopropynyl)-1-methylpyrazol and also of tocopherol antioxidant and gutumine antihypoxant averts activation of the lipids peroxidation processes. The inhibition of peroxidation with the studied agents is attended by stabilization of lyzosomal and mitochondrial membranes. Unsaturated amines prevent destruction of the organelles membranes provoked by the UV-irradiation and incubation at 37 degrees C (pH--4.7).
D000135:Acid Phosphatase / Q000528:radiation effects; D000480:Alkynes / Q000627:therapeutic use; D000531:Altitude; D000578:Amidines / Q000627:therapeutic use*; D000588:Amines / Q000627:therapeutic use*; D000818:Animals; D004353:Drug Evaluation, Preclinical; D005334:Fever / Q000378:metabolism*; D000860:Hypoxia / Q000378:metabolism*; D007700:Kinetics; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism*; D008247:Lysosomes / Q000201:enzymology; D010084:Oxidation-Reduction; D010545:Peroxides / Q000378:metabolism; D051381:Rats; D013890:Thiourea / Q000031:analogs & derivatives* / Q000627:therapeutic use; D013997:Time Factors; D014466:Ultraviolet Rays; D014810:Vitamin E / Q000627:therapeutic use
D000480:Alkynes; D000578:Amidines; D000588:Amines; D010545:Peroxides; D014810:Vitamin E; D000135:Acid Phosphatase; D013890:Thiourea
Vliianie gipoksii i gipertermii na protsessy perekisnogo okisleniia lipidov pecheni krys na fone deĭstviia gutimina i nenasyshchennykh aminov.