Differential radiation response amongst proliferating epithelial cells.
Tissue irradiation results in both reproductive and histologically evident cell death. The correlation between these is poor. Irrespective of dose and fraction sterilized, many cells behave as if unirradiated (cell cycle and maturation activity). The fraction of histologically observable dead cells is usually less than 0.1, with most in the intestine being positioned in the presumptive stem cell region. The data strongly suggest different epithelial sub-populations with differing radioresponses. These may be the stem and differentiated proliferative cells.
D000818:Animals; D002453:Cell Cycle / Q000528:radiation effects*; D002465:Cell Movement / Q000528:radiation effects; D002470:Cell Survival / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D000078404:Epidermal Cells; D004817:Epidermis / Q000528:radiation effects; D005720:Gamma Rays; D007413:Intestinal Mucosa / Q000166:cytology / Q000528:radiation effects*; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D014316:Tritium / Q000494:pharmacology; D014965:X-Rays
D014316:Tritium