Subpopulations of cytogenetically abnormal cells in fibroblast cultures derived from workers exposed to mineral oil.
Fibroblast cultures were grown from skin biopsy specimens from individuals with a high risk of cancer due to occupational exposure to mineral oil. A high frequency of chromosomally abnormal fibroblast subpopulations was found in cultures derived from tissue that had been exposed to the carcinogen, but these aberrant clonal populations were also present in control lines from the same individuals. Abnormal clones formed a greater proportion of the total cell population in the lines derived from the oil-exposed tissue compared with the control lines after a comparable time in culture. This difference in clone size may be a consequence of the in vivo exposure to mineral oil or other environmental agents.
D000368:Aged; D002869:Chromosome Aberrations; D002999:Clone Cells / Q000648:ultrastructure; D005347:Fibroblasts / Q000648:ultrastructure*; D005834:Genital Neoplasms, Male / Q000209:etiology* / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D008899:Mineral Oil / Q000009:adverse effects*; D009784:Occupational Diseases / Q000209:etiology* / Q000235:genetics; D012611:Scrotum; D012878:Skin Neoplasms / Q000209:etiology* / Q000235:genetics
D008899:Mineral Oil