[Functional studies of the cardia muscles in achalasia].
1. The mechanical properties - extension behaviour and ability to contract per muscle cross-section - were the same for healthy and aganglionic cardiac sphincter. 2. The acetyl choline threshold is higher in aganglionic muscle strips. The maximum effective acetyl choline dose (2 microgram/ml) remained the same. 3. Achalasia is characterized by a considerable reduction of adrenergic beta-receptor activity and alpha-receptor predominance.
D000109:Acetylcholine / Q000494:pharmacology; D002217:Carbachol / Q000494:pharmacology; D002299:Cardia / Q000187:drug effects / Q000503:physiopathology*; D004931:Esophageal Achalasia / Q000503:physiopathology*; D006801:Humans; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000503:physiopathology*
D002217:Carbachol; D000109:Acetylcholine
Funktionelle Untersuchungen an der Kardiamuskulatur bei Achalaisie.