Endometrial stromal sarcoma arising from vaginal endometriosis.
The present case reports the concurrence of endometriosis of the vaginal cuff with endometrial stromal sarcoma in association with high-dose estrogen. This case raises the question of whether chronic high-dose estrogen might be associated with malignant transformation of endometrial stroma. Although there is no definitive evidence of a causal relation between estrogen and endometrial stromal sarcoma, the possibility should be explored further. Therapy of this neoplasm is discussed and salient clinical and pathologic features are reviewed.
D004715:Endometriosis / Q000150:complications / Q000473:pathology*; D004967:Estrogens / Q000009:adverse effects; D005260:Female; D006801:Humans; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary; D012509:Sarcoma / Q000139:chemically induced / Q000150:complications / Q000473:pathology*; D014594:Uterine Neoplasms / Q000139:chemically induced / Q000150:complications / Q000473:pathology*; D014625:Vaginal Neoplasms / Q000150:complications / Q000473:pathology*
D004967:Estrogens