Serial sacrifice study of pathogenesis of 210Po-induced lung tumors in Syrian golden hamsters.
The pathogenesis of 210Po-induced tumors in the peripheral lung of Syrian golden hamsters has been studied in a serial sacrifice experiment utilizing both plastic (glycol methacrylate) and routine paraffin embedding procedures for lung sections. A rapid progression from hyperplasia of bronchiolar-type cells that appear in the alveolar region to malignant tumors was documented. Tumors began appearing as early as 15 weeks after the first intratracheal instillation of 210Po.
D000230:Adenocarcinoma / Q000209:etiology; D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000209:etiology; D006224:Cricetinae; D006965:Hyperplasia; D008175:Lung Neoplasms / Q000209:etiology* / Q000473:pathology; D008297:Male; D008647:Mesocricetus; D009374:Neoplasms, Experimental / Q000209:etiology; D009381:Neoplasms, Radiation-Induced / Q000209:etiology* / Q000473:pathology; D011059:Polonium / Q000633:toxicity*; D011230:Precancerous Conditions / Q000209:etiology* / Q000473:pathology; D013997:Time Factors
D011059:Polonium