The relation between plasma androstenedione, plasma oestrone and androstenedione to oestrone conversion rates in post-menopausal women with and without fractures.
1. Plasma androstenedione, plasma oestrone and the conversion of plasma androstenedione into oestrone were measured in 19 post-menopausal women without fractures (six of them oophorectomized) and 18 with vertebral or femoral neck fractures (four of them oophorectomized). 2. In the series as a whole, the main determinant of the plasma oestrone level was the plasma androstenedione concentration. Only in the small oophorectomized group did the variation in conversion rate make a significant contribution to the variation in plasma oestrone. 3. The conversion rates were not different as between non-fracture and fracture cases but the mean plasma androstenedione and oestrone concentrations were lower (though not significantly) in the latter.
D000311:Adrenal Glands / Q000378:metabolism; D000367:Age Factors; D000368:Aged; D000735:Androstenedione / Q000097:blood* / Q000378:metabolism; D002369:Castration; D004970:Estrone / Q000097:blood* / Q000378:metabolism; D005260:Female; D050723:Fractures, Bone / Q000097:blood*; D006801:Humans; D008593:Menopause; D008875:Middle Aged
D004970:Estrone; D000735:Androstenedione