Prophylactic intraperitoneal povidone-iodine in alimentary tract surgery.
In controlled experiments intraperitoneal povidone-iodine significantly reduced the mortality of mice (p less than 0.01) and rats (p less than 0.01) with induced peritonitis. Povidone-iodine irrigation of the rat colon before and after anastomosis did not interfere with healing or inhibit peritoneal adhesion formation. However, a newly formulated povidone-iodine solution containing increased PVP significantly reduced adhesion formation in a controlled study in rats.
D000818:Animals; D003108:Colonic Diseases / Q000517:prevention & control; D005260:Female; D005767:Gastrointestinal Diseases / Q000601:surgery*; D007274:Injections, Intraperitoneal; D051379:Mice; D010529:Peritoneal Cavity; D010532:Peritoneal Diseases / Q000517:prevention & control; D010538:Peritonitis / Q000517:prevention & control; D011183:Postoperative Complications / Q000517:prevention & control*; D011205:Povidone / Q000031:analogs & derivatives*; D011206:Povidone-Iodine / Q000008:administration & dosage* / Q000627:therapeutic use; D051381:Rats; D000267:Tissue Adhesions; D014945:Wound Healing / Q000187:drug effects
D011206:Povidone-Iodine; D011205:Povidone