Small virus-like particles in leukosis-like syndrome induced by certain antigens and immunostimulators.
A transmissible syndrome which is characterized by splenomegaly and myeloid metaplasia was induced in BALB/c mice by injections of certain homologous and heterologous antigens and complete Freund's adjuvant or dextransulfate. From the plasma of these animals small viruslike particles (30--50 nm) were isolated.
D000818:Animals; D003911:Dextrans / Q000494:pharmacology; D005260:Female; D005620:Freund's Adjuvant / Q000494:pharmacology; D007114:Immunization; D008206:Lymphatic Diseases / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D008854:Microscopy, Electron; D013154:Spleen / Q000473:pathology; D013163:Splenomegaly / Q000382:microbiology / Q000473:pathology; D014780:Viruses / Q000302:isolation & purification*
D003911:Dextrans; D005620:Freund's Adjuvant