Augmentation of wound tensile strength in rats by induction of inflammation with autogenous blood.
Accelerated wound healing should be possible if one could eliminate the lag phase, a period of time when the wound is quite weak while the building blocks of collagen are being brought into the wound. In the present experiments injection of autogenous blood into the skin and fascia of rats initiated a response characterized by vasodilatation, accumulation of inflammatory cells, and proliferation of capillaries and fibroblasts. During the first week of healing, wounds made in areas injected with blood 2 days prior to wounding were up to twice as strong as controls.
D000818:Animals; D001769:Blood; D002196:Capillaries / Q000473:pathology; D005205:Fascia; D005347:Fibroblasts / Q000473:pathology; D007249:Inflammation / Q000209:etiology* / Q000473:pathology; D051381:Rats; D012867:Skin; D013718:Tensile Strength; D013997:Time Factors; D014664:Vasodilation; D014945:Wound Healing