Effect of collagen on thrombin inactivation by antithrombin-III and heparin.
Thrombin inactivation by antithrombin-III and heparin has been found to decrease in the presence of collagen, whereas thrombin activity and the rate of thrombin inactivation by antithrombin-III alone are not affected. Albumin, at the same concentration as collagen, does not influence either thrombin activity or thrombin inactivation by antithrombin-III or by antithrombin-III plus heparin.
D000818:Animals; D000991:Antithrombins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D002417:Cattle; D003094:Collagen / Q000378:metabolism / Q000494:pharmacology*; D006493:Heparin / Q000378:metabolism; D006494:Heparin Antagonists; D012710:Serum Albumin, Bovine / Q000494:pharmacology; D013917:Thrombin / Q000378:metabolism*
D000991:Antithrombins; D006494:Heparin Antagonists; D012710:Serum Albumin, Bovine; D006493:Heparin; D003094:Collagen; D013917:Thrombin