Fluorometric determination of some butyrophenones after permanganate treatment.
A fluorometric method is described for direct and sensitive determinations of azaperone, haloperidol and bromoperidol in pharmaceutical preparations. These compounds can be converted into strongly fluorescing derivatives by the action of potassium permanganate on their alcoholic solutions in acid medium, the limits of detection being respectively 8.10(-3), 5.10(-2) microgram/ml. The fluorescence phenomenon is very stable. Preliminary results are reported on the isolation and structure determination of one of the main fluorophors, produced in the case of azaperone.
D001376:Azaperone / Q000032:analysis*; D002090:Butyrophenones / Q000032:analysis*; D002855:Chromatography, Thin Layer; D005470:Fluorometry; D006220:Haloperidol / Q000031:analogs & derivatives* / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008722:Methods; D011196:Potassium Permanganate; D013054:Spectrophotometry, Atomic; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D002090:Butyrophenones; D011196:Potassium Permanganate; D001376:Azaperone; D006220:Haloperidol; C006820:bromperidol