Protein secretion from parotid glands of vitamin D deficient and glucocorticoid-treated rats.
The rate of isoproterenol stimulated secretion of protein from parotid glands of vitamin D deficient rats and rats treated with methylprednisolone was increased compared to the secretory response of tissue from control rats. It is suggested that the increased secretory response is secondary to a decreased capacity of mitochondria from the tissue of these animals to take up and store Ca2+; i.e. the mitochondria are less efficient buffers of cytoplasmic Ca2+. Under these conditions any process, such as protein secretion, which requires an increased cytoplasmic Ca2+ concentration will operate more effectively.
D000818:Animals; D002118:Calcium / Q000378:metabolism; D007545:Isoproterenol / Q000494:pharmacology; D007930:Leucine / Q000378:metabolism; D008775:Methylprednisolone / Q000494:pharmacology*; D010306:Parotid Gland / Q000378:metabolism*; D051381:Rats; D012471:Salivary Proteins and Peptides / Q000378:metabolism*; D014808:Vitamin D Deficiency / Q000378:metabolism*
D012471:Salivary Proteins and Peptides; D007930:Leucine; D007545:Isoproterenol; D002118:Calcium; D008775:Methylprednisolone