Transplantation immunity in the brain.
The resistance of animals to allogeneic tumor cells injected into the brain increases with age. The second-set reaction in the brain of rats appears to be equally effective after preimmunization into the brain and preimmunization into the leg. Also, the presence of cytotoxic antibodies is demonstrable after preimmunization into the brain. These findings suggest that both arcs of the transplantation reaction, the afferent and efferent, are involved in tumor-cell allotransplantation in the brain.
D000367:Age Factors; D000818:Animals; D001921:Brain / Q000276:immunology* / Q000473:pathology; D001932:Brain Neoplasms / Q000473:pathology; D003602:Cytotoxicity, Immunologic; D007114:Immunization; D009368:Neoplasm Transplantation; D051381:Rats; D012513:Sarcoma, Experimental / Q000473:pathology; D014181:Transplantation Immunology; D014184:Transplantation, Homologous