[Relationship between the effectiveness of the antitumor action of sarcolysine and the latency period between transplantation and tumor appearance].
Sarcoma induced with 3-methylcholantrene in mice was transplanted to syngeneic recipients. The latent period of the tumour growth varied from 7 to 26 days. Sarcolysine was injected once when the tumour became palpable. When the tumours were revealed 7 to 8 and 10 to 15 days after the inoculation, the tumour growth inhibition was accompanied by increased survival of mice, particularly marked at the latter period. When the tumours were revealed 17 to 20 or 22 to 26 days after the transplantation, inhibition of the tumour growth was not accompanied by any increase of survival.
D000818:Animals; D008558:Melphalan / Q000627:therapeutic use*; D008748:Methylcholanthrene; D051379:Mice; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D012513:Sarcoma, Experimental / Q000139:chemically induced / Q000188:drug therapy*; D013997:Time Factors
D008748:Methylcholanthrene; D008558:Melphalan
Effektivnost' protivoopukholevogo deĭstviia sarkolizina v zavisimosti ot vremeni poiavleniia opukholi posle perevivki.