Phosphorus-nitrogen compounds. 21. Murine oncolytic and antifertility effect of adamantylaziridine compounds.
P,P-Bis(1-aziridinyl)-N-adamantylphosphinic amide and N,N'-bis(ethylene)-P-(1-adamantyl)phosphonic diamide were synthesized as potential anticancer and male antifertility agents. Log P values (octanol-water) of the agents were determined and compared to calculated values. Both derivatives displayed intraperitoneal murine antileukemic activity and antifertility effects when given intraperitoneally and orally.
D000218:Adamantane / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D001388:Aziridines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D001389:Azirines / Q000138:chemical synthesis*; D001952:Bridged-Ring Compounds / Q000138:chemical synthesis*; D003272:Contraceptive Agents, Male / Q000138:chemical synthesis*; D007939:Leukemia L1210 / Q000188:drug therapy; D008297:Male; D051379:Mice
D000970:Antineoplastic Agents; D001388:Aziridines; D001389:Azirines; D001952:Bridged-Ring Compounds; D003272:Contraceptive Agents, Male; D000218:Adamantane