Pharmacologic effects in man of a specific serotonin-reuptake inhibitor.
Fluoxetine (Li-ly 110140) caused a 63 percent inhibition of [3H]serotonin uptake into platelets obtained from normal volunteers to whom the drug was administered daily for 7 days. This dose had no effect on the usual pressor response produced by injections of norepinephrine or tyramine.
D001519:Behavior / Q000187:drug effects; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D006801:Humans; D009638:Norepinephrine / Q000494:pharmacology; D010647:Phenyl Ethers / Q000494:pharmacology; D011437:Propylamines / Q000494:pharmacology*; D012701:Serotonin / Q000097:blood*; D012702:Serotonin Antagonists / Q000494:pharmacology; D014439:Tyramine / Q000494:pharmacology
D010647:Phenyl Ethers; D011437:Propylamines; D012702:Serotonin Antagonists; D012701:Serotonin; D009638:Norepinephrine; D014439:Tyramine