Immunoglobulin (Gm) allotypes in a sample of Canadian Ashkenazic Jews.
Gm typing on the serum specimens of 507 Ashkenazic Jews (pre-dominantly of Polish-Russian ancestry) from Toronto, Canada has established the presence of haplotypes Gm3;5, Gm1;21, Gm1,2;21, and Gm1,17;5, and the absence of haplotypes Gm1;13,15,16, Gm1;5,6, and Gm1;5,6,24 which have been found in other Jewish peoples. It is suggested that Ashkenazic populations have lower frequencies of haplotype Gm1,17;5 than non-European Jewish populations, and that some eastern European Jewish populations have acquired the Gm1;13,15,16 haplotype through gene flow from Central Asia. Thus Jewish populations show differences in the Gm system; many of the differences may be in the direction of similarities to neighbouring non-Jewish populations.
D002170:Canada; D006801:Humans; D007136:Immunoglobulins / Q000235:genetics*; D007519:Isoantigens / Q000235:genetics*; D007585:Jews; D011044:Poland / Q000208:ethnology; D012425:Russia (Pre-1917) / Q000208:ethnology
D007136:Immunoglobulins; D007519:Isoantigens