[Effect of the plan of using antitumor preparations on their efficacy in sarcoma 37].
In tests staged on animals with sarcome 37 the effect of sarcolysine, cyclophosphamide, alexan and cytozine-arabinozine was studied with different scemes of their application. It was found that the degree to which the drugs inhibit the growth of sarcoma 37 depends on the scheme adopted for their administration. In the case of sarcolyzine the highest effect was achieved with a 5-day introduction of the drug (93 per cent of inhibition and resorption of some tumours); cyclophosphamide proved effective with its single administration or an introduction with an interval of 96 hours (78 per cent of inhibition), alexan was active with a 5- and 10-day courses (78 per cent of inhibition and resorption of some tumours). Sarcoma 37 is shown to be a suitable model for studying the activity of drugs depending upon the scheme of their application.
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D003520:Cyclophosphamide / Q000008:administration & dosage; D003561:Cytarabine / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D007274:Injections, Intraperitoneal; D008558:Melphalan / Q000008:administration & dosage; D051379:Mice; D009368:Neoplasm Transplantation; D012511:Sarcoma 37 / Q000188:drug therapy*; D013997:Time Factors
D000970:Antineoplastic Agents; D003561:Cytarabine; D003520:Cyclophosphamide; D008558:Melphalan
Vliianie skhemy primeneniia protivoopukholevykh preparatov na ikh éffektivnost' pri sarkome 37.