[Tryptophan uptake by glia and synaptosomes of rabbit cerebral cortex].
The authors studied the engulfment of L-tryptophane-14C by gliacytes and synaptosomes of the rabbit cerebral cortex. The system of engulfment of the gliacytes was characterized by a high affinity to tryptophane (Km = 0.8 micrometer). Engulfment of tryptophane by synaptosomes had a lower affinity (Km = 50 micrometer). Psychotropic substances--chlorpromazine and imipramine produced an inhibitory influence on glial engulfment. The leading role of gliacytes in the trophic provision of the neurons and the normal course of neurodynamic processes is confirmed.
D000818:Animals; D002540:Cerebral Cortex / Q000166:cytology / Q000378:metabolism* / Q000648:ultrastructure; D002746:Chlorpromazine / Q000494:pharmacology; D003042:Cocaine / Q000494:pharmacology; D007099:Imipramine / Q000494:pharmacology; D007700:Kinetics; D009457:Neuroglia / Q000378:metabolism*; D011817:Rabbits; D013574:Synaptosomes / Q000378:metabolism*; D014272:Trifluperidol / Q000494:pharmacology; D014364:Tryptophan / Q000378:metabolism*
D014364:Tryptophan; D003042:Cocaine; D007099:Imipramine; D014272:Trifluperidol; D002746:Chlorpromazine
Zakhvat triptofana kletkami glii i sinaptosomami kory golovnogo mozga krolika.