Effect of F-leurosine (formyl-leurosine) on platelet production in mice.
F-leurosine (formyl-leurosine) was found to exert a thrombocytopoietic effect in CFLP mice. The effect was most pronounced in a dose of 1.0 mg/kg. The increased activity of the megakaryocyte system was not due to thrombocytopenia. The preparation induced in the bone marrow an increasing megakaryocyte formation (increase of the megakaryocyte index, a shift to the left in the qualitative composition of the giant cells, increase of the 75Se-methionine incorporation). F-leurosine seems to exert its effect through a direct stimulation of the megakaryocyte system, which might be utilized in therapy.
D000818:Animals; D001792:Blood Platelets / Q000187:drug effects*; D001854:Bone Marrow Cells; D002454:Cell Differentiation; D004305:Dose-Response Relationship, Drug; D008297:Male; D008533:Megakaryocytes / Q000187:drug effects*; D051379:Mice; D008934:Mitogens; D013921:Thrombocytopenia / Q000139:chemically induced*; D014748:Vinca Alkaloids / Q000494:pharmacology*
D008934:Mitogens; D014748:Vinca Alkaloids