Acute cardiac failure: the relation between coronary flow and oxygen consumption.
In an initial study with dog hearts functioning in situ on total coronary bypass, we demonstrated that predetermined levels of reduced cardiac pump function could be achieved by reducing total coronary flow through changes in the perfusing pressure. In subsequent experiments, oxygen values were measured so that changes in myocardial aerobic consumption in response to brief (3 minute) alterations in coronary perfusing pressure could be determined as well. As a result significant linear correlations were found between coronary flow and myocardial oxygen availability (r = 0.98), oxygen extraction (r = 0.49) and oxygen consumption (r = 0.92). These changes in oxygen values paralleled those in cardiac function (stroke work, r = 0.84).
D000818:Animals; D003326:Coronary Circulation; D003327:Coronary Disease / Q000378:metabolism / Q000503:physiopathology*; D004195:Disease Models, Animal; D004285:Dogs; D006321:Heart / Q000503:physiopathology; D008297:Male; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism*; D010101:Oxygen Consumption; D010477:Perfusion / Q000379:methods