[Synthesis and pharmacological activity of esters and amides of 4-phenylcoumarin-3-carboxylic acid].
The synthesis and pharmacological activity of a series of dialkylaminoalkyl esters and dialkylaminoalkyl amides of 4-phenylisocoumarin-3-carboxylic acid are described. The esters show anticoagulant activity whereas the amides show marked antiarhythmic activity.
D000577:Amides / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis*; D000925:Anticoagulants / Q000138:chemical synthesis*; D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D004952:Esters / Q000138:chemical synthesis / Q000494:pharmacology; D051379:Mice; D009043:Motor Activity / Q000187:drug effects
D000577:Amides; D000889:Anti-Arrhythmia Agents; D000925:Anticoagulants; D002264:Carboxylic Acids; D004952:Esters
Sintesi e attività farmacologica di esteri ed amidi dell'acido 4-fenilisocumarin-3-carbossilico.