Experimental pancreatic carcinogenesis. II. Lifetime carcinogenesis studies in the outbred Syrian golden hamster with N-nitroso-bis(2-hydroxypropyl)amine.
A high incidence of pancreatic duct neoplasms was induced in outbred male Syrian golden hamsters following weekly sc injection of N-nitroso-bis(2-hydroxypropyl)amine for life. The first such tumors appeared as early as 16 experimental weeks; the maximum incidence reached 100% by the termination of the study. Tumors in the respiratory tracts and angiosarcomas of the livers of the hamsters were also observed in high frequency. Latency of the induced neoplasms was significantly decreased by the substitution of distilled water for olive oil as the vehicle for the carcinogen.
D000818:Animals; D006224:Cricetinae; D008113:Liver Neoplasms / Q000139:chemically induced; D008297:Male; D008647:Mesocricetus; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009378:Neoplasms, Multiple Primary / Q000139:chemically induced; D009602:Nitrosamines / Q000008:administration & dosage / Q000633:toxicity*; D009821:Oils; D010183:Pancreatic Ducts; D010190:Pancreatic Neoplasms / Q000139:chemically induced*; D011437:Propylamines / Q000008:administration & dosage / Q000633:toxicity; D012142:Respiratory Tract Neoplasms / Q000139:chemically induced; D013997:Time Factors; D014867:Water
D009602:Nitrosamines; D009821:Oils; D011437:Propylamines; D014867:Water; C012457:diisopropanolnitrosamine