[Study of optimal posology of penicillamine in the treatment of common rheumatoid polyarthritis (apropos of a personal series of 200 cases)].
A comparison of two series of patients with rhe,matic polyarthritis, the one (n = 140) treated with dosage equal to or higher than 900 mg, the other (n = 60) with dosage between 600 and 750 mg, did not reveal significant difference in clinical and biological efficacy. The number of side-effects was not significantly reduced by lower dosage, except for digestive tract disorders. A reduction of dosage does, therefore, not permit less strict supervision and monitoring for side-effects of treatment.
D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010396:Penicillamine / Q000008:administration & dosage* / Q000627:therapeutic use
D010396:Penicillamine
Recherche d'une posologie optimale de la pénicillamine dans le traitement de la polyarthrite rhumatoïde commune. A propos d'une série personnelle de 200 cas.