L-Dopa methyl ester: prolongation of survival of neuroblastoma-bearing mice after treatment.
L-Dopa has has been shown to demonstrate enhanced toxicity toward melanoma cells in vitro. Since melanocytes arise from the neural crest embryologically, the effect of L-dopa methyl ester, a soluble analog, on the murine C1300 neuroblastoma was studied. There was significant antitumor activity against the neuroblastoma, which was enhanced by combination with a dopa decarboxylase inhibitor, Ro4-4602. In vitro studies suggested inhibition of DNA synthesis as the principal site of action. A mechanism involving sulfhydryl compound scavenging is postulated.
D000818:Animals; D001545:Benserazide / Q000494:pharmacology; D002460:Cell Line; D004357:Drug Synergism; D007930:Leucine / Q000378:metabolism; D007980:Levodopa / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000378:metabolism; D009447:Neuroblastoma / Q000188:drug therapy* / Q000378:metabolism; D013936:Thymidine / Q000378:metabolism; D014529:Uridine / Q000378:metabolism
D007980:Levodopa; D001545:Benserazide; D007930:Leucine; D013936:Thymidine; D014529:Uridine