Failure of somatostatin to diagnose organic hyperinsulinism.
In four patients with organic hyperinsulinism (two with surgically proven beta-cell adenomas of the body of the pancreas) a standard tolbutamide test during continuous somatostatin infusion (5 microgram/min) was carried out. Tolbutamide induced insulin release was completely inhibited by somatostatin as in normal subjects. These results suggest that the inhibition test with somatostatin does not seem to be a better or safer way of diagnosing insulin producing tumours.
D000328:Adult; D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000175:diagnosis*; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D008875:Middle Aged; D012636:Secretory Rate / Q000187:drug effects; D013004:Somatostatin / Q000494:pharmacology; D014044:Tolbutamide
D007328:Insulin; D013004:Somatostatin; D014044:Tolbutamide