Pathogenesis of Dupuytren's contracture: a correlative clinical-pathological study.
The tissue from 38 patients with Dupuytren's contracture was submitted for light and electron microscopy. The clinical and pathological data were correlated so that three stages of disease were recognized: early, active, and advanced. The cell of early disease was the perivascular fibroblast; whereas, the cell of active disease was the myofibroblast. Because the myofibroblasts have cell-to-cell and cell-to-stroma attachments, the collagen not only becomes oriented as it is formed, but it also is subjected to a contractile force.
D000328:Adult; D000368:Aged; D004387:Dupuytren Contracture / Q000209:etiology / Q000473:pathology*; D005205:Fascia / Q000473:pathology; D005260:Female; D005347:Fibroblasts / Q000648:ultrastructure; D006225:Hand; D006801:Humans; D007365:Intercellular Junctions / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged