3-Benzazocine amidinium nitronates. An unusual type of opiate antagonist.
An interesting type of 3-benzazocine ring system which contains amidine functionality has been found to have significant narcotic antagonist activity. The isomeric 2-benzazocine, which incorporates similar structural features, except for the position of the ring nitrogen and adjacent phenyl substituent, is inactive. These 2- and 3-benzazocines can be synthesized in a single step from appropriately structured amidines and naphthalenes, and such syntheses may provide useful routes to new and interesting types of narcotic antagonists.
D000578:Amidines / Q000138:chemical synthesis / Q000494:pharmacology; D000700:Analgesics / Q000138:chemical synthesis; D000818:Animals; D001392:Azocines / Q000138:chemical synthesis* / Q000494:pharmacology; D051379:Mice; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000138:chemical synthesis*; D011930:Reaction Time / Q000187:drug effects; D013329:Structure-Activity Relationship; D013997:Time Factors
D000578:Amidines; D000700:Analgesics; D001392:Azocines; D009292:Narcotic Antagonists; D009270:Naloxone