Oestradiol production by human graafian follicles cultured in vitro.
Intact human Graafian follicles recovered during the preovulatory phase of the menstrual cycle and cultured in vitro, gave a mean oestradiol production of 33 ng/hour over periods of 4 to 92 hours. Treatment of follicles with human pituitary gonadotrophin or human chorionic gonadotrophin resulted in an increased production of oestradiol.
D000328:Adult; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D046508:Culture Techniques; D004958:Estradiol / Q000096:biosynthesis*; D005260:Female; D006065:Gonadotropins, Pituitary / Q000494:pharmacology; D006801:Humans; D008598:Menstruation; D008875:Middle Aged; D006080:Ovarian Follicle / Q000033:anatomy & histology / Q000187:drug effects / Q000378:metabolism*
D006063:Chorionic Gonadotropin; D006065:Gonadotropins, Pituitary; D004958:Estradiol