[Effect of dopamine, histamine and acetylcholine on the distribution of cardiac output in the anesthetized rat (author's transl)].
1. The distribution of cardiac output has been studied in rats, using 15 micrometer radioactive microspheres, before and during an I. V. infusion of dopamine, histamine and acetylcholine (3 microgram/kg/min for 3 min). 2. Dopamine decreased the fraction of cardiac output in the spleen (-26%), colon (-23%) and portal vein (-16%) but did not change significantly the flow fraction delivered to the kidneys. 3. Histamine increased the fraction of cardiac output in the stomach (+66%), pancreas (+42%), small intestine (+15%) and decreased it in the colon (-22%) and kidneys (-12%. 4. Acetylcholine reduced the fraction of cardiac output in the colon (-45%), small intestine and spleen (-24%) and increased it in the liver (hepatic artery, +62%). 5. The fractions of microspheres trapped in the lungs were enhanced by histamine (+69%) and acetylcholine (+111%), probably due to an increase in the fraction of cardiac output passing through the peripheral arteriovenous anastomoses.
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D002302:Cardiac Output / Q000187:drug effects*; D004064:Digestive System / Q000098:blood supply; D004298:Dopamine / Q000494:pharmacology*; D006632:Histamine / Q000494:pharmacology*; D007668:Kidney / Q000098:blood supply; D011168:Portal System / Q000187:drug effects; D051381:Rats; D012039:Regional Blood Flow / Q000187:drug effects; D013154:Spleen / Q000098:blood supply
D006632:Histamine; D000109:Acetylcholine; D004298:Dopamine
Influence de la dopamine, de l'histamine et de l'acétylcholine sur la distribution du débit cardiaque chez le rat anesthésié.