Intraventricular chloramphenicol.
Very high intraventricular chloramphenicol levels can be obtained if the standard systemic dose is supplemented with a small intraventricular dose. Chloramphenicol sodium succinate can be hydrolyzed to the microbiologically active chloramphenicol in the ventricular fluid. Daily injections are ordinarily adequate to maintain a high concentration of antibiotic. Initial dosage should vary with ventricular volume. The brain does not tolerate repeated needle puncture and the use of a ventriculostomy reservoir is recommended.
D000818:Animals; D002701:Chloramphenicol / Q000008:administration & dosage* / Q000097:blood; D004285:Dogs; D006801:Humans; D006849:Hydrocephalus / Q000150:complications; D007223:Infant; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000188:drug therapy; D007276:Injections, Intraventricular; D008581:Meningitis / Q000188:drug therapy*
D002701:Chloramphenicol