Ticrynafen, a uricosuric antihypertensive diuretic.
Ticrynafen, a diuretic-uricosuric also effective as an antihypertensive, was compared in single doses with several other diuretics. Over an 8-hr period, a 250- mg dose exerted natriuretic activity comparable to that of 25 mg of chlorthalidone and 50 mg of ethacrynic acid; a 500-mg dose was comparable to 50 mg chlorthalidone and 50 mg hydrochlorothiazide. Ticrynafen combined with furosemide had an additive effect, whereas a combination with hydrochlorothiazide was not additive. In both doses ticrynafen was a uricosuric and this effect was maintained when given with furosemide and hydrochlorothiazide, both of which individually were slightly antiuricosuric. Ticrynafen may be useful in patients requiring a diuretic in whom it is desirable to avoid hyperuricemia.
D000328:Adult; D000959:Antihypertensive Agents / Q000494:pharmacology*; D002752:Chlorthalidone / Q000494:pharmacology; D004232:Diuretics / Q000494:pharmacology*; D004347:Drug Interactions; D004976:Ethacrynic Acid / Q000494:pharmacology; D005665:Furosemide / Q000494:pharmacology; D006016:Glycolates / Q000494:pharmacology*; D006801:Humans; D006852:Hydrochlorothiazide / Q000494:pharmacology; D008297:Male; D009318:Natriuresis / Q000187:drug effects; D010642:Phenoxyacetates / Q000494:pharmacology*; D013876:Thiophenes / Q000494:pharmacology*; D014528:Uricosuric Agents
D000959:Antihypertensive Agents; D004232:Diuretics; D006016:Glycolates; D010642:Phenoxyacetates; D013876:Thiophenes; D014528:Uricosuric Agents; D006852:Hydrochlorothiazide; D005665:Furosemide; D004976:Ethacrynic Acid; D002752:Chlorthalidone