[Effect of bonaphthone on embryogenesis in white rats and mice].
Results of testing the embryotropic activity of bonaphthone used in different doses (700; 400; 100; 50 and 2 mg/kg) are reported. With its oral introduction to pregnant rats bonaphthone, given in doses at the level of the therapeutid one (2 mg/kg) and exceeding it by as much as 25 times (50 mg/kg), was found not to produce any damaging effect on the fetus. With its action in doses of 100 and 400 mg/kg a slight embryotoxic effect was noted. In the sublethal dose of 700 mg/kg the preparation displays a moderate embryotoxic action and produces a number of circulatory changes in the fetuses. It is concluded that bonaphthone displays no teratogenic properties.
D000284:Administration, Oral; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004622:Embryo, Mammalian / Q000187:drug effects; D004627:Embryonic Induction / Q000187:drug effects*; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D005333:Fetus / Q000187:drug effects; D007274:Injections, Intraperitoneal; D051379:Mice; D009285:Naphthoquinones / Q000494:pharmacology*; D010920:Placenta / Q000187:drug effects; D011247:Pregnancy; D051381:Rats; D013723:Teratogens; D013997:Time Factors
D009285:Naphthoquinones; D013723:Teratogens
Vliianie bonaftona na émbriogenez belykh krys i mysheĭ.