Response of chondrocytes isolated from human foetal cartilage to plasma somatomedin activity.
Plasma somatomedin activity enhanced the incorporation of [3H]thymidine into chondrocytes isolated from human foetal cartilage during weeks 13-21 of gestation. Human growth hormone (0.1-20 muu./ml), human placental lactogen (0.1-5 microgram/ml) and insulin (0.25-10 muu./ml) had no direct effects on the synthesis of DNA in these chondrocytes, although insulin at concentrations of 2.5-100 mu./ml increased [3H]thymidine incorporation by up to 400%.
D002356:Cartilage / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D004247:DNA / Q000096:biosynthesis; D006801:Humans; D007328:Insulin / Q000494:pharmacology; D013002:Somatomedins / Q000097:blood*; D013936:Thymidine / Q000378:metabolism
D007328:Insulin; D013002:Somatomedins; D004247:DNA; D013936:Thymidine