Uterine rupture: a complication of midtrimester abortion.
The intraamniotic injection of prostaglandin F2alpha and/or hypertonic saline may be associated with serious uterine and cervical trauma. Multiparity and superimposed uterotonic stimulation by oxytocin are generally thought to be contributory. A patient is described who failed to abort vaginally after an uneventful intraamniotic infusion of prostaglandin F2 alpha in combination with hypertonic saline; 48 hours later she evacuated the uterine contents into the peritoneal cavity through a rent in the uterine fundus. The uterine rupture occurred even though there had been no uterotonic stimulation by oxytocin.
D000028:Abortion, Induced; D000328:Adult; D005260:Female; D006801:Humans; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011460:Prostaglandins F / Q000009:adverse effects* / Q000627:therapeutic use; D012462:Saline Solution, Hypertonic / Q000627:therapeutic use; D014597:Uterine Rupture / Q000139:chemically induced*
D011460:Prostaglandins F; D012462:Saline Solution, Hypertonic