Collagen crosslinking in keratoconus.
The examination of reducible collagen crosslinks in keratoconus cornea revealed the presence of lysinonorleucine in amounts far greater than in normal age-matched corneas. There was no indication of decreased hydroxylysine levels in keratoconus, and there were no clinical indications of a generalized connective tissue disorder. The abnormal levels of dehydrolysinonorleucine in the tissue may represent a change in hydroxylation of selected lysyl residues of normal collagen or the synthesis of abnormal collagen, perhaps an unusual type.
D000328:Adult; D003094:Collagen / Q000032:analysis* / Q000096:biosynthesis; D003315:Cornea / Q000032:analysis*; D005260:Female; D006801:Humans; D007640:Keratoconus / Q000378:metabolism*; D008239:Lysine / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009646:Norleucine / Q000032:analysis
D009646:Norleucine; D003094:Collagen; D008239:Lysine