Isolation of mutagens from bacterial nutrients containing beef extract.
The enhanced rate of mutation of Salmonella strain TA1538 (Ames) by microsomes results from the presence of about 2--5 ppm of microsome-activatable mutagens in bacterial nutrient broths that contain beef extract. Since mutagens toward Salmonella are likely to be carcinogenic, the data have significant implications for the problem of carcinogenesis.
D000818:Animals; D002417:Cattle; D003470:Culture Media; D066298:In Vitro Techniques; D008862:Microsomes, Liver / Q000201:enzymology; D009153:Mutagens; D051381:Rats; D012475:Salmonella / Q000235:genetics; D013997:Time Factors; D014020:Tissue Extracts / Q000032:analysis / Q000494:pharmacology*
D003470:Culture Media; D009153:Mutagens; D014020:Tissue Extracts