Quantitation of anticonvulsant drugs in serum by gas-chromatography on the stationary phase SP-2510.
A new column packing, SP-2510 DA (Supelco, Inc., Bellefonte, Pa. 16823), is an excellent stationary phase for the determination of a wide variety of anticonvulsant drugs by gas--liquid chromatography without derivatization. However, when uncomplicated extraction procedures are used, serum cholesterol interferes with the determination of primidone. By the simple expedient of adding a short "pre-column" containing another phase (SP-2250 DA) the problem is overcome.
D000927:Anticonvulsants / Q000097:blood* / Q000627:therapeutic use; D002849:Chromatography, Gas / Q000379:methods; D004827:Epilepsy / Q000188:drug therapy; D006801:Humans
D000927:Anticonvulsants