[Effect of hydrocortisone on the ribonucleic acid biosynthesis in the liver mitochondria, heart and spleen of rats with alloxan diabetes].
Mitochondrial RNA biosynthesis in diabetic rats under the influence of hydrocortisone (0.5 or 2 U per 100 g for 7 days) increased in the liver and decreased in the spleen. Heart mitochondrial RNA biosynthesis increased after hydrocortisone injection in a dose of 0.5 U per 100 g, but decreased after hormone administration in a dose of 2.5 U per 100 g. Thus, hydrocortisone played an important role in the changes of RNA biosynthesis in the liver, heart, and spleen mitochondria of diabetic animals.
D000818:Animals; D003864:Depression, Chemical; D003921:Diabetes Mellitus, Experimental / Q000473:pathology*; D006854:Hydrocortisone / Q000494:pharmacology*; D008297:Male; D008928:Mitochondria / Q000378:metabolism*; D008929:Mitochondria, Heart / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000378:metabolism*; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D013154:Spleen / Q000378:metabolism*; D013268:Stimulation, Chemical
D012313:RNA; D006854:Hydrocortisone
Vliianie gidrokortizona na biosintez ribonukleinovykh kislot v mitokhondriiakh pecheni, serdtsa i selezenki krys s alloksanovym diabetom.