Reflux mechanisms involved in cardiac arrhythmias induced by hypothalamic stimulation.
Electrical stimulation of widespread areas in the CNS has been shown to cause cardiac arrhythmias, which occur most frequently after cessation of stimulation. To determine the reflex and autonomic mechanism responsible for the poststimulation arrhythmias, we anesthetized cats with chloralose, and recorded arterial pressure, ECG, and cardiac vagal nerve activity. Stimulation of the hypothalamus consistently caused increases in blood pressure and heart rate during stimulation and caused arrhythmias, accompanied by vagal hyperactivity, immediately following stimulation. The arrhythmias were mediated solely by the vagus nerves because vagotomy or propantheline administration prevented them, whereas propranolol did not. Administration of either phentolamine or spinal cord transection prevented both the rise in blood pressure during stimulation and the poststimulation arrhythmias, but sectioning the carotid sinus and aortic depressor nerves had no preventative effect. However, when this denervation was combined with sectioning of vagal afferents, bursts of vagal activity (used as an index of cardiac rhythm disturbances) were prevented in three of six animals. Subsequent administration of phentolamine prevented the bursts in the remaining animals. It is concluded that poststimulation arrhythmias are elicited by the rise in blood pressure occurring during stimulation causing a sudden surge in parasympathetic outflow to the heart. The reflexogenic areas involved appear to be stretch receptors innervated by afferent vagal fibers.
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000503:physiopathology*; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D004558:Electric Stimulation; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D007031:Hypothalamus / Q000502:physiology*; D008297:Male; D010646:Phentolamine / Q000494:pharmacology; D011311:Pressoreceptors / Q000502:physiology; D011413:Propantheline / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D012018:Reflex / Q000502:physiology*; D013116:Spinal Cord / Q000502:physiology; D014630:Vagus Nerve / Q000502:physiology
D011413:Propantheline; D011433:Propranolol; D010646:Phentolamine