The alcohol syndromes: the intrarecombigenic effect of acetaldehyde.
Sister chromatid exchange was studied in lymphocyte and fibroblast cultures. Alcohol caused no disturbance under normal conditions but an acetaldehyde level above 40 muM inhibited cell multiplication and elevated SCE considerably. A high acetaldehyde level is thought to elicit the fetal alcohol syndrome, a view supported by clinical and experimental observations.
D000079:Acetaldehyde / Q000494:pharmacology*; D000437:Alcoholism / Q000097:blood / Q000235:genetics*; D002478:Cells, Cultured; D002842:Chromatids / Q000187:drug effects; D004221:Disulfiram / Q000494:pharmacology; D000431:Ethanol / Q000097:blood; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D008940:Mitotic Index / Q000187:drug effects; D011995:Recombination, Genetic
D000431:Ethanol; D000079:Acetaldehyde; D004221:Disulfiram