Modification of vascular response to synthetic oxytocin by oestrogen in rabbit.
Intravenously administered oxytocin caused a dose-related fall in blood pressure of the rabbit. When oxytocin was administered in oestrogen-primed animals, the depressor response was converted to a pressor one "Oxytocin reversal". The "oxytocin reversal." was abolished after treatment with dihydroergotamine, hexamethonium or adrenalectomy. The "oxytocin reversal" did not appear in reserpinized animals.
D000315:Adrenalectomy; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004087:Dihydroergotamine / Q000494:pharmacology; D004964:Estriol / Q000031:analogs & derivatives / Q000494:pharmacology; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D006584:Hexamethonium Compounds / Q000494:pharmacology; D008297:Male; D010121:Oxytocin / Q000494:pharmacology*; D010197:Pancuronium / Q000031:analogs & derivatives / Q000494:pharmacology; D011817:Rabbits; D012110:Reserpine / Q000494:pharmacology; D013268:Stimulation, Chemical
D004967:Estrogens; D006584:Hexamethonium Compounds; D004087:Dihydroergotamine; D010121:Oxytocin; D012110:Reserpine; D004964:Estriol; D010197:Pancuronium