[1-11C] DL-valine, a potential pancreas-imaging agent.
There is a great need for a better pancreas-imaging agent. Studies with [1-14C] DL-valine have shown this amino acid to have a high pancreatic specificity in the four animal species examined. The tissue distribution was almost optimal by 30 min after injection, and no carrier effect was observed through a dose of 5 mg/kg. [1-11C] DL-Valine was synthesized in amounts up to 363 mCi using a rapid (T1/2 = 20.4 min for C-11), high-temperature, high-pressure modification of the Bücherer-Strecker amino acid synthesis. Purification was by anion-exchange followed by cation-exchange chromatography. [1-11C] DL-Valine was obtained in a 70% chemical yield with a total synthesis and purification time of 45 min. Studies in animals have demonstrated that it is a potentially useful new agent for clinical pancreatic imaging.
D000818:Animals; D002250:Carbon Radioisotopes; D006224:Cricetinae; D004285:Dogs; D005215:Fasting; D005260:Female; D007553:Isotope Labeling; D008297:Male; D008647:Mesocricetus; D010179:Pancreas / Q000000981:diagnostic imaging*; D011817:Rabbits; D011877:Radionuclide Imaging; D051381:Rats; D011916:Rats, Inbred F344; D013997:Time Factors; D014018:Tissue Distribution; D014633:Valine / Q000138:chemical synthesis / Q000378:metabolism
D002250:Carbon Radioisotopes; D014633:Valine