Effects of topical 1-epinephrine and dipivalyl epinephrine on intraocular pressure and pupil size in the normotensive and glaucomatous Beagle.
Dipivalyl epinephrine and l-epinephrine were evaluated in various concentrations in normotensive and glaucomatous Beagles. In higher concentrations, both drugs produced significant lowering of intraocular pressure. Mydriasis and some local irritation occurred. The hypotony after drug administration tended to be greater in glaucomatous than in normotensive Beagles. The glaucomatous Beagle may be a valuable biomedical model in the investigation of various pharmacologic substances.
D000818:Animals; D004283:Dog Diseases / Q000503:physiopathology*; D004285:Dogs / Q000502:physiology*; D004837:Epinephrine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology*; D005901:Glaucoma / Q000503:physiopathology / Q000662:veterinary*; D007429:Intraocular Pressure / Q000187:drug effects*; D009883:Ophthalmic Solutions; D011680:Pupil / Q000187:drug effects*
D009883:Ophthalmic Solutions; C015173:dipivefrin; D004837:Epinephrine