Fascicular nerve allograft evaluation. Part 1: comparison with autografts by light microscopy.
In a comparative experiment, transplantation of orthotopic nerve fascicle was performed on 100 sciatic nerves between inbred, antigenically identified rats. The authors studied cellular response, macrophage reaction, connective-tissue reaction, myelination, and distal/proximal axonal ratios, but no difference could be established between allografted and autografted fascicles after 2 months. Moreover, there was no evidence of any graded rejection phenomenon dependent on differences of tissue typing. Theories for the decreased antigenic reaction of nerve fascicles are proposed.
D000818:Animals; D006084:Graft Rejection; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012584:Sciatic Nerve / Q000033:anatomy & histology / Q000637:transplantation*; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous