Cyclical thrombocytopenia with remission during lynestrenol treatment in a woman.
A woman of 40 had cyclical thrombocytopenia occurring midway between menstruations, with bruising and platelet counts down to 2000/mm3. The thrombocytopenic episodes disappeared after treatment with lynestrenol was started. The patient's platelets had a functional defect of the "aspirin-like" type. The availability of platelet factor 3 increased when oestrogen was added to platelet-rich plasma from the patient.
D000328:Adult; D004997:Ethinyl Estradiol / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008234:Lynestrenol / Q000627:therapeutic use*; D008598:Menstruation / Q000187:drug effects; D009644:Norgestrel / Q000627:therapeutic use; D010974:Platelet Aggregation / Q000187:drug effects; D010977:Platelet Factor 3 / Q000502:physiology; D012075:Remission, Spontaneous; D013921:Thrombocytopenia / Q000188:drug therapy*
D010977:Platelet Factor 3; D009644:Norgestrel; D004997:Ethinyl Estradiol; D008234:Lynestrenol