Suppression of pathogenicity by P and V plasmids in Vibrio cholerae.
In experimental models of cholera, some strains of Vibrio cholerae harbouring P or V or both plasmids were markedly less pathogenic than isogenic strains devoid of these plasmids. This effect was due to decreased production of toxin by P+, V+ or P+V+ bacteria compared with their parents.
D000818:Animals; D002771:Cholera / Q000209:etiology; D002772:Cholera Toxin / Q000032:analysis; D007928:Lethal Dose 50; D051379:Mice; D010957:Plasmids; D011817:Rabbits; D014734:Vibrio cholerae / Q000235:genetics / Q000472:pathogenicity*; D014774:Virulence
D002772:Cholera Toxin