[Effect of phenobarbital on the bile-forming function of the liver].
In tests with 178 albino male-rats the effect of phenobarbital in doses of 30--100 mg/kg, administered intraperinoneally singly and multiply, on the biligenic function of the liver was studied. The drug was found to act beneficially on the intensity of biligenesis, the synthesis of primary bile acids and their cojugation with taurine and glycine, as well as on the formation of and cojugation with glucoronic acid and secretion of bilirubin. This action of phenobarbital continues also in the progeny of the female rats receiving phenobarbital at different periods of pregnancy.
D000818:Animals; D001646:Bile / Q000187:drug effects* / Q000378:metabolism; D001647:Bile Acids and Salts / Q000096:biosynthesis; D001663:Bilirubin / Q000096:biosynthesis; D002756:Cholagogues and Choleretics; D002784:Cholesterol / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005260:Female; D005965:Glucuronates / Q000378:metabolism; D008099:Liver / Q000187:drug effects*; D008297:Male; D010634:Phenobarbital / Q000494:pharmacology*; D011247:Pregnancy; D051381:Rats; D013997:Time Factors
D001647:Bile Acids and Salts; D002756:Cholagogues and Choleretics; D005965:Glucuronates; D002784:Cholesterol; D001663:Bilirubin; D010634:Phenobarbital
Vliianie fenobarbitala na zhelcheobrazovatel'nuiu funktsiiu pecheni.