The histidine analogue L-histidinol arrests the growth of BALB/3T3 cells in G0.
The histidine analogue L-histidinol inhibits the growth of Balb/3T3 cells in a dose-dependent manner and concentrations of 1 or 2 mM cause a total but completely reversible growth arrest. Growth resumption which follows removal of the analogue shows kinetics and requirements indistinguishable from those of quiescent cells stimulated to proliferate by fresh serum. Cells which have progressed beyond the G1/S boundary appear to complete the cell cycle in the presence of L-histidinol and become arrested in the subsequent G1 or G0.
D002452:Cell Count; D002453:Cell Cycle / Q000187:drug effects*; D002460:Cell Line; D004247:DNA / Q000096:biosynthesis; D004305:Dose-Response Relationship, Drug; D006641:Histidinol / Q000494:pharmacology*; D006918:Hydroxyurea / Q000494:pharmacology; D007093:Imidazoles / Q000494:pharmacology*
D007093:Imidazoles; D006641:Histidinol; D004247:DNA; D006918:Hydroxyurea