Some effects of mianserine (ORG GB 94) on amine metabolism in the rat brain.
The effects of the tetracyclic antidepressant drug mainserine (code Nr. ORG GB 94) on biogenic amine metabolism in the rat brain are summarized. After either acute or chronic administration, mianserine increases the turnover of noradrenaline without appreciably affecting that of dopamine or serotonin. No evidence can be found that it affects amine reuptake in vivo. In its effect on amine turnover and reuptake, mianserine differs qualitatively from the dibenzazepine antidepressants. It is concluded that drugs need not be amine reuptake inhibitors before they are considered to be potential antidepressants.
D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism*; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D003984:Dibenzazepines / Q000494:pharmacology*; D008803:Mianserin / Q000494:pharmacology*; D051381:Rats
D001679:Biogenic Amines; D003984:Dibenzazepines; D008803:Mianserin