Lability of renal papillary tissue composition in the rat.
1. The acute effects of (a) a minor operative procedure using ether as the anaesthetic, and (b) the administration of 0.9% saline as a single I.V. injection in the conscious rat, on renal tissue composition were studied in hydropenic and normally hydrated rats. 2. The operative procedure and anaesthesia induced a rapid and transient decrease in papillary osmolality in both hydropenic and normally hydrated animals, the important contributing factor being a significant decrease in urea content. 3. Administration of a small volume of saline caused a rapid decrease in urea content, and an increase in water content. 4. It is concluded that papillary composition is extremely labile, large changes being produced by relatively minor experimental procedures.
D000777:Anesthetics; D000818:Animals; D004986:Ether; D007668:Kidney / Q000032:analysis / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009994:Osmolar Concentration; D051381:Rats; D012964:Sodium / Q000032:analysis; D012965:Sodium Chloride / Q000494:pharmacology; D013514:Surgical Procedures, Operative; D014508:Urea / Q000032:analysis
D000777:Anesthetics; D004986:Ether; D012965:Sodium Chloride; D014508:Urea; D012964:Sodium