[Quantitative EEG analysis of the effects of carbocromen, pentetrazole, beta-methyldigoxin, and strophantin-K in normal human volunteers (author's transl)].
With EEG-interval analysis we studied the influence on C.N.S. of some drugs normally used for cardiovascular diseases: carbochromen, pentetrazole, beta-methyldigoxin and Strophantin-K. All investigated drugs induced activation of alpha-waves, especially in frontal areas with primary small alpha-activity. Dominant alpha-frequency was accelerated. These results confirm the direct and stimulating effects of these drugs on C.N.S. in therapeutic doses. Alpha-acceleration may not only indicate psychostimulation but also indicate epileptogenic effects. All these drugs may provoke epileptic seizures in toxic doses.
D000328:Adult; D000368:Aged; D000513:Alpha Rhythm; D002866:Chromonar / Q000494:pharmacology*; D003374:Coumarins / Q000494:pharmacology*; D003529:Cymarine / Q000494:pharmacology*; D004077:Digoxin / Q000031:analogs & derivatives*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D008520:Medigoxin / Q000494:pharmacology*; D008875:Middle Aged; D010433:Pentylenetetrazole / Q000494:pharmacology*; D010919:Placebos; D013328:Strophanthins / Q000494:pharmacology*
D003374:Coumarins; D010919:Placebos; D013328:Strophanthins; D004077:Digoxin; D008520:Medigoxin; D002866:Chromonar; D003529:Cymarine; D010433:Pentylenetetrazole
Quantitative EEG-Untersuchungen nach Einnahme der kreislaufwirksamen Mittel Carbochromen, Pentetrazol, Beta-Methyl-Digoxin und K-Strophantin.