Acute leukopenia associated with silver sulfadiazine therapy.
A patient with a 30% scald burn was treated with topical silver sulfadiazine (Silvadene). On two occasions, within 48 hours of treatment, the patient developed acute leukopenia. Bone marrow aspiration revealed cell maturation arrest. The possible mechanisms of this leukopenia are discussed. It is recommended that daily leukocyte counts be done in burn patients being treated with silver sulfadiazine.
D000208:Acute Disease; D002056:Burns / Q000188:drug therapy; D006801:Humans; D007970:Leukopenia / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D012837:Silver Sulfadiazine / Q000009:adverse effects* / Q000627:therapeutic use; D013411:Sulfadiazine / Q000009:adverse effects*
D013411:Sulfadiazine; D012837:Silver Sulfadiazine