Effect of trimethoprim-sulphamethoxazole on vibrio clearance in cholera (El Tor): a comparative study.
The efficacy of trimethoprim-sulphamethoxazole (TMP-SMX) has been compared with that of tetracycline and chloramphenicol in 175 bacteriologically confirmed cases of cholera admitted to the Infectious Diseases Hospital Delhi. Vibrio cholerae, biotype El Tor, serotype ogawa, were isolated from all the patients. TMP-SMX showed greater in vitro inhibition and earlier eradication from the intestinal tract and is recommended as a suitable vibriocidal agent against cholera.
D002701:Chloramphenicol / Q000627:therapeutic use; D002771:Cholera / Q000188:drug therapy*; D004338:Drug Combinations; D006801:Humans; D007194:India; D013420:Sulfamethoxazole / Q000627:therapeutic use*; D013752:Tetracycline / Q000627:therapeutic use; D014295:Trimethoprim / Q000627:therapeutic use*; D014734:Vibrio cholerae / Q000187:drug effects
D004338:Drug Combinations; D002701:Chloramphenicol; D014295:Trimethoprim; D013752:Tetracycline; D013420:Sulfamethoxazole