Ano-rectal manometry in the diagnosis of Hirschsprung's disease in infants.
Manometric recordings of internal sphincter activity were performed during distension of the rectum in 10 healthy control infants and in 9 infants with clinical signs of Hirschsprung's disease. In 8 of the healthy infants relaxations of the internal sphincter were obtained, which were maximal 4 to 7 secs after rectal distension. This was also the case in 5 of the patients who were later proven not to have Hirschsprung's disease. In 3 patients no relaxations of the internal sphincter could be recorded. Subsequent rectal biopsy revealed absence of ganglion cells, confirming the diagnosis Hirschsprung's disease. The remaining 3 infants (2 controls and 1 patient) could not be calmed during the examination and the results were inconclusive. It is concluded that ano-rectal manometry is a valuable method of examination in the diagnosis of Hirschsprung's disease in infants. No false results were obtained in this study. Furthermore, it is an easy procedure without risk or discomfort for the patient.
D000367:Age Factors; D001003:Anal Canal / Q000503:physiopathology*; D001835:Body Weight; D005769:Gastrointestinal Motility; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008365:Manometry / Q000295:instrumentation; D008531:Megacolon / Q000175:diagnosis* / Q000503:physiopathology; D009126:Muscle Relaxation; D011312:Pressure; D012007:Rectum / Q000502:physiology*