Tryptophan excretion by a bradytroph of Hansenula polymorpha growing in methanol.
The growth of a bradytrophic mutant isolated from the methanol-utilizing yeast Hansenula polymorpha was found to be stimulated by both tyrosine and phenylalanine. The mutant contained about half as much chorismate mutase activity as the wild-type strain. When grown in a medium containing 2% mehtanol as the major carbon and energy source, the bradytroph excreted a low but significant level (28 mg/liter) of L-tryptophan.
D001203:Ascomycota / Q000378:metabolism*; D002826:Chorismate Mutase / Q000378:metabolism; D000432:Methanol / Q000378:metabolism*; D009154:Mutation; D010649:Phenylalanine / Q000494:pharmacology; D010843:Pichia / Q000378:metabolism*; D014364:Tryptophan / Q000096:biosynthesis*; D014443:Tyrosine / Q000494:pharmacology
D014443:Tyrosine; D010649:Phenylalanine; D014364:Tryptophan; D002826:Chorismate Mutase; D000432:Methanol