[Inhibiting effect of anabasine, anabasamine and lupinine alkaloids on ethanol action in mice].
Anabisis aphylla alcaloids anabasine, anabasamine and lupinine (1/6 and 1/3) DL50, intraperitoneally) lowered the locomotion excitation called forth by aethanol (2 mg/g, by mouth) in mice. Lupinine shortened roughly by a foctor of 3 also the duration of aethanol anesthesia. The reduced excitation was attended by falling a blood aethanol concentration, while shortening of the anesthesia period was not, this suggesting different mechanisms in two disclosed antialcoholic effects of the alcaloids.
D000470:Alkaloids / Q000494:pharmacology*; D000691:Anabasine / Q000031:analogs & derivatives / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000037:antagonists & inhibitors* / Q000097:blood; D005260:Female; D008124:Locomotion / Q000187:drug effects; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010880:Piperidines / Q000494:pharmacology*; D011807:Quinolizines / Q000494:pharmacology*; D013034:Sparteine / Q000031:analogs & derivatives; D013997:Time Factors; D000093843:Quinolizidine Alkaloids
D000470:Alkaloids; D000691:Anabasine; D000431:Ethanol; D010880:Piperidines; D011807:Quinolizines; D013034:Sparteine; C015679:anabasamine; C015971:lupinine; D000093843:Quinolizidine Alkaloids
Tormoziashchee vliianie alkaloidov anabazina, anabazamina i lupinina na deĭstvie étanola u mysheĭ.