Sulfhydryl groups and the monodeiodination of thyroxine to triiodothyronine.
Sulfhydryl reagents exert a profound influence on the monodeiodination of thyroxine to triiodothyronine by rat and sheep tissues in vitro. A marked dithiothreitol-induced increase in the monodeiodination by fetal sheep liver homogenates suggests that the characteristically low conversion in fetal tissues is related more to the status of sulfhydryl groups than to a deficiency of the monodeiodinating enzyme.
D000818:Animals; D004229:Dithiothreitol / Q000494:pharmacology; D005260:Female; D005333:Fetus / Q000378:metabolism*; D008099:Liver / Q000196:embryology / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D012756:Sheep; D013438:Sulfhydryl Compounds / Q000378:metabolism*; D013439:Sulfhydryl Reagents / Q000494:pharmacology; D013974:Thyroxine / Q000378:metabolism*; D014284:Triiodothyronine / Q000378:metabolism*
D013438:Sulfhydryl Compounds; D013439:Sulfhydryl Reagents; D014284:Triiodothyronine; D013974:Thyroxine; D004229:Dithiothreitol