Carcinogenicity of 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide (AF-2) fed to female Sprague-Dawley rats.
The carcinogenicity of 2-(2-furyl)-3-(5-nitro-5-furyl)acrylamide (AF-2) was investigated by administering it orally to Sprague-Dawley female weanling rats in a grain diet at a dose of 0.2% for 46 weeks, followed by 20 weeks of unmedicated control diet. The total mean cumulative dose of AF-2 was 10.1 g (41.6 mmol) per rat during the 46 weeks of the experiment. Weight gains of rats fed AF-2 was comparable to that of unmedicated control rats. Survival of rats fed AF-2 was 52 +/- 12 (SD) weeds compared to 65 +/- 5 weeks for the unmedicated controls (P less than 0.001). Twenty-four of 29 rats fed AF-2 developed multiple breast tumors, 15 of which were adenocarcinomas. Two of 29 unmedicated control rats had single fibroadenomas of the breast.
D000230:Adenocarcinoma / Q000139:chemically induced*; D000232:Adenofibroma / Q000139:chemically induced*; D000818:Animals; D005260:Female; D005668:Furylfuramide / Q000008:administration & dosage / Q000633:toxicity*; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced*; D009581:Nitrofurans / Q000633:toxicity*; D051381:Rats
D009581:Nitrofurans; D005668:Furylfuramide