Platelet size distribution in mice following immunothrombopenia and vincristine administration.
In the present study platelet size distribution was investigated after induction of immunothrombocytopenia by rabbit-anti-mouse-platelet-serum (RAMPS) and after vincristine-induced thrombocytopenia. The platelet size distribution after a single dose of RAMPS showed a shift to larger volumes at day 1 and 2, and a decrease to slightly smaller volumes than normal at day 8. These differences, however, were not statistically significant. After vincristine administration, a dose-dependent increase of the platelet size distribution was demonstrated, which lasted from day 1-7. It is suggested that in immune-induced thrombocytopenia the young platelets released from bone marrow megakaryocytes are not exclusively large platelets. On the other hand the early appearance of large platelets after vincristine administration points to a toxic or segregating effect of vincristine on circulating platelets. Therefore, in our experiments, the platelet size is not suitable for the differentiation of young and old platelets.
D000818:Animals; D001792:Blood Platelets; D002452:Cell Count; D007154:Immune System Diseases / Q000097:blood*; D008297:Male; D051379:Mice; D009929:Organ Size; D011817:Rabbits / Q000276:immunology; D013921:Thrombocytopenia / Q000097:blood* / Q000139:chemically induced; D013997:Time Factors; D014750:Vincristine / Q000633:toxicity*
D014750:Vincristine