Effects of flufenamic acid, dexamethasone, and SP 54 (a pentosanpolysulphate) on the histological appearance of murine embryonic tibia explants cultured in vitro.
The histological investigation of cultured, embryonic tibia explants of NMRI-mice showed, after a six day period, that incubation concentrations of Flufenamic acid, SP54 (a Pentosanopolysulphate), and Dexamethasone (9alpha-Fluor-16-beta-Methyl-Prednisolone) predominantly induced resorptive and degenerative processes, in different degrees, affecting cartilage and bone matrix. In the experiments with Flufenamic acid and Dexamethasone, the degenerative processes were found to be accompanied by the inhibition of the synthesis of cartilage matrix. The investigations with SP54, on the other hand, showed a medium increase of cartilage matrix.
D000818:Animals; D002113:Calcification, Physiologic / Q000187:drug effects; D003907:Dexamethasone / Q000494:pharmacology*; D005260:Female; D005439:Flufenamic Acid / Q000494:pharmacology*; D051379:Mice; D009924:Organ Culture Techniques; D010426:Pentosan Sulfuric Polyester / Q000494:pharmacology*; D011134:Polysaccharides / Q000494:pharmacology*; D011247:Pregnancy; D013977:Tibia / Q000033:anatomy & histology* / Q000187:drug effects / Q000196:embryology; D013997:Time Factors
D011134:Polysaccharides; D010426:Pentosan Sulfuric Polyester; D005439:Flufenamic Acid; D003907:Dexamethasone