Neurotrophic protein regulates muscle acetylcholinesterase in culture.
Skeletal muscles lose acetylcholinesterase in culture as a result of denervation. A protein fraction isolated from peripheral nerves maintained the level of acetylcholinesterase in cultures of aneural embryonic muscle or denervated adult chicken muscle. These results indicate that trophic regulation of muscle acetylcholinesterase might be mediated by a protein produced by nerves.
D000110:Acetylcholinesterase / Q000096:biosynthesis / Q000378:metabolism*; D002478:Cells, Cultured; D004790:Enzyme Induction / Q000187:drug effects; D009121:Muscle Denervation; D009132:Muscles / Q000201:enzymology*; D009419:Nerve Tissue Proteins / Q000494:pharmacology*; D010525:Peripheral Nerves / Q000502:physiology*
D009419:Nerve Tissue Proteins; D000110:Acetylcholinesterase