[Nucleic acid and protein biosynthesis in the accessory sex organs of rats during blockade of testosterone effect by androgen antagonist 4-nitro-3-trifluoromethylisobutyranilide].
The influence of testosterone and antiandrogen 4-nitro-3-trifluoromethylisobutyranilide (4N3TFMIBA) on the content and biosynthesis of nucleic acids and the protein in the ventral prostate and the seminal vesicles of Wistar rats was studied under experimental conditions. As revealed, with the simultaneous administration of the androgen and its antagonist there was a fall in the organs under study of the RNA and protein content and a reduction of incorporation of labeled precursors into the DNA, RNA, and protein. Similar changes were seen after castration. A conclusion was drawn that the capacity to block the stimulating influence of testosterone on the nucleic acid and protein biosynthesis underlay "castration" effects of antiandrogen 4N3TFMIBA, this causing atrophy of the accessory genital apparatus.
D000813:Anilides / Q000494:pharmacology*; D000818:Animals; D004247:DNA / Q000096:biosynthesis*; D005485:Flutamide / Q000494:pharmacology*; D008297:Male; D009698:Nucleoproteins / Q000096:biosynthesis*; D011467:Prostate / Q000378:metabolism*; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D012669:Seminal Vesicles / Q000378:metabolism*; D013739:Testosterone / Q000037:antagonists & inhibitors* / Q000494:pharmacology
D000813:Anilides; D009698:Nucleoproteins; D013739:Testosterone; D012313:RNA; D005485:Flutamide; D004247:DNA
Biosintez nukleinovykh kislot i belka aktsessornykh polovykh organakh krys pri blokade deĭstviia testosterona antiandrogenom 4-nitro-3-triftormetilizobutiranilidom.