Amantadine: neuromuscular blockade by suppression of ionic conductance of the acetylcholine receptor.
Amantadine hydrochloride decreases the sensitivity of denervated mammalian muscle to iontophoretically applied acetylcholine. The drug depresses the amplitude of the end-plate current and reverses the slope of the relation between half-decay time and membrane potential suggesting that it alters the ionic conductance that is mediated by the acetylcholine receptor. Binding studies confirm that amantadine acts on the ion conductance modulator rather than the acetylcholine receptor.
D000109:Acetylcholine / Q000378:metabolism / Q000502:physiology*; D000547:Amantadine / Q000494:pharmacology*; D000818:Animals; D004553:Electric Conductivity; D004557:Electric Organ / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D005399:Fishes; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D009045:Motor Endplate / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D009121:Muscle Denervation; D009132:Muscles / Q000294:innervation / Q000378:metabolism; D009466:Neuromuscular Blocking Agents; D009469:Neuromuscular Junction / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D051381:Rats; D011950:Receptors, Cholinergic / Q000187:drug effects*; D011978:Receptors, Nicotinic / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D014118:Toxins, Biological / Q000378:metabolism
D009466:Neuromuscular Blocking Agents; D011950:Receptors, Cholinergic; D011978:Receptors, Nicotinic; D014118:Toxins, Biological; D000547:Amantadine; D000109:Acetylcholine