Effect of vitamin D in fluoride-treated rats.
Fluoridated drinking water (30 mg and 100 mg F per liter) was used to induce rachitic changes in rats fed a vitamin D free diet containing calcium and phosphorus in a ratio of 1 : 1. Supplements of vitamin D3 (70 IU of cholecalciferol per week) completely prevented the rachitogenic effects of fluoride. This protective effect occurred despite evidence that vitamin D enhanced the intestinal absorption of fluoride.
D000818:Animals; D001847:Bone Diseases / Q000139:chemically induced / Q000517:prevention & control; D002130:Calcium Phosphates / Q000378:metabolism; D002136:Calcium, Dietary; D005457:Fluoridation; D005459:Fluorides / Q000009:adverse effects* / Q000627:therapeutic use; D007408:Intestinal Absorption / Q000187:drug effects; D008274:Magnesium / Q000378:metabolism; D008297:Male; D008954:Models, Biological; D010024:Osteoporosis / Q000188:drug therapy; D010758:Phosphorus / Q000378:metabolism; D051381:Rats; D012279:Rickets / Q000139:chemically induced / Q000517:prevention & control; D014807:Vitamin D / Q000627:therapeutic use*; D014808:Vitamin D Deficiency / Q000473:pathology
D002130:Calcium Phosphates; D002136:Calcium, Dietary; D014807:Vitamin D; D010758:Phosphorus; D008274:Magnesium; D005459:Fluorides