Treatment of urinary tract infections in children with a single daily dose of gentamicin.
21 children with recurrent urinary tract infections (UTI) due to bacteria resistant to the usual antiinfectious drugs were examined to evaluate whether their UTI could be effectively treated with a single daily administration of gentamicin (2.5 mg/kg i.m.) for ten days. From the data obtained it may be concluded that such a scheme of therapy is effective in all cases as far as urine sterilization is concerned during therapy, regardless of the site of infection. However, urine culture controls, 10 and 30 days after therapy was discontinued, showed a further infection in 3 out of 7 children with upper UTI, Since in urine of all our patients the antibiotic level was well above the minimal inhibitory concentration for the infective bacteria, the different therapeutic response could be related to an inadequate antibiotic concentration at the renal interstitial site.
D001424:Bacterial Infections / Q000188:drug therapy*; D001437:Bacteriuria; D002648:Child; D002675:Child, Preschool; D004341:Drug Evaluation; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D008297:Male; D012008:Recurrence; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000382:microbiology
D005839:Gentamicins