Brain histamine receptors as targets for antidepressant drugs.
A large number of structurally diverse drugs with clinical antidepressant properties share the ability to act as potent inhibitors of histamine-sensitive adenylate cyclase in cell-free preparations from mammalian brain. This common biochemical action may represent part of the molecular basis for the antidepressant properties of these compounds.
D000067956:Adenylyl Cyclase Inhibitors; D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D001679:Biogenic Amines / Q000378:metabolism; D001921:Brain / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D004789:Enzyme Activation / Q000187:drug effects; D006168:Guinea Pigs; D006632:Histamine / Q000378:metabolism / Q000502:physiology; D066298:In Vitro Techniques; D007700:Kinetics; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D011968:Receptors, Histamine / Q000187:drug effects* / Q000378:metabolism; D013329:Structure-Activity Relationship
D000067956:Adenylyl Cyclase Inhibitors; D000929:Antidepressive Agents, Tricyclic; D001679:Biogenic Amines; D008996:Monoamine Oxidase Inhibitors; D011968:Receptors, Histamine; D006632:Histamine; D000262:Adenylyl Cyclases