Aflatoxicol: major aflatoxin B1 metabolite in rat plasma.
Aflatoxicol, a carcinogenic metabolite of the foodborne carcinogen aflatoxin B1 previously known only as a bioreduction product in vitro, was identified as the major aflatoxin metabolite in the plasma of Sprague-Dawley rats, a susceptible species, that had been doses orally or intravenously with aflatoxin B1 labeled with carbon-14. Alfatoxicol, however, was not detected in the plasma of similarly dosed mice and monkeys, which are both resistant to aflatoxin B1-induced cardinogenesis. The formation of aflatoxicol both in vitro and in vivo may be an indicatory of species sensitivity to aflatoxin-induced carcinogenesis and may be useful in the prediction of human susceptibility.
D000348:Aflatoxins / Q000097:blood* / Q000378:metabolism; D000818:Animals; D001711:Biotransformation; D001798:Blood Proteins / Q000378:metabolism; D011485:Protein Binding; D051381:Rats; D013045:Species Specificity
D000348:Aflatoxins; D001798:Blood Proteins; C012170:aflatoxicol