The fate of [103Ru]ruthenocene in mice and rats.
1. The metabolic fate, rate of excretion and organ distribution of [103Ru]ruthenocene, administered to mice intravenously, intraperitoneally and orally, were investigated. 2. Most of the 103Ru was eliminated from the body in 24 h; the remainder was located mostly in liver, gastro-intestinal tract and fat and was slowly excreted. 3. The 103Ru was excreted in the bile and urine as ruthenocene-O-glucuronide, as shown by enzymic hydrolysis and mass spectrum of the permethylated metabolite.
D000818:Animals; D005260:Female; D005965:Glucuronates / Q000096:biosynthesis; D008297:Male; D013058:Mass Spectrometry; D051379:Mice; D009942:Organometallic Compounds / Q000378:metabolism*; D011868:Radioisotopes; D051381:Rats; D012428:Ruthenium / Q000378:metabolism*; D014018:Tissue Distribution
D005965:Glucuronates; D009942:Organometallic Compounds; D011868:Radioisotopes; C016721:ruthenocene; D012428:Ruthenium