The effects of topical instillation of adriamycin in bladder tumors of rats fed with FANFT.
Topical bladder instillation of adriamycin was evaluated in FANET produced rat tumors produced by diets containing (N-[4-(5-Nitro-2-Furyl)-2-Thiazolyl] Formamide). The drug was ineffective in either preventing or eradicating tumors. The failure of response in this animal model may be related to drug schedule, biological potential of this tumor, or ineffectiveness of Adriamycin in this tumor.
D000287:Administration, Topical; D000818:Animals; D004317:Doxorubicin / Q000008:administration & dosage* / Q000627:therapeutic use; D005200:FANFT; D005260:Female; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control; D051381:Rats; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced / Q000188:drug therapy* / Q000517:prevention & control
D005200:FANFT; D004317:Doxorubicin