Further studies on the structural requirements of sugars as antagonists of the changes in vascular permeability produced by sugar polymers in rat skin.
Hexoses and pentoses, but not tetroses or trioses, are potent inhibitors of the increase in vascular permeability in rat skin produced by the polysaccharides--dextran, mannan and glucan. The most active sugars are those with a D-threo type of structure in their cyclic form. The alcohols corresponding to the active sugars are much less inhibitory in this test. The results provide further information on the possible role of carbohydrate structures in antibody binding.
D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects*; D055598:Chemical Phenomena; D002621:Chemistry; D003911:Dextrans / Q000494:pharmacology*; D008351:Mannans / Q000494:pharmacology*; D011134:Polysaccharides / Q000494:pharmacology*; D051381:Rats
D003911:Dextrans; D008351:Mannans; D011134:Polysaccharides