Glucose disappearance in infants of diabetic mothers. II. Relationship to lowest neonatal blood glucose and amniotic fluid insulin.
Neonatal glucose disappearance (KT) was measured in 26 infants of insulin-dependent diabetic mothers within the first 2 h of life. A significant correlation was found between the KT and the lowest blood glucose (LBG) in the first day of life (r = 0.64, P less than 0.001). None of 21 infants developed a LBG less than 20 mg/dl when the KT was less than 3.0%/min in contrast to 4 of 5 whose KT was greater than 3.0%/min (P less than 0.001). Amniotic fluid (AF) glucose and insulin were determined in 42 samples from 18 of these patients in the third trimester of pregnancy. There was a significant correlation between AF insulin values and the neonatal KT (R = 0.76, P less than 0.001). The correlation was higher when only amniotic fluid values obtained on the day of delivery were considered (n = 17, r = 0.90, P less than 0.001). 1 of 13 infants developed a LBG less than 20 mg/dl when the amniotic fluid insulin was less than 100 mu U/ml on the day of delivery in contrast to 3 of 4 whose AF insulin was greater than 100 mu U/ml (P less than 0.001). No correlation of AF glucose was found with infants' KT or LBG. These data suggest that both neonatal KT and AF insulin are of value for predicting neonatal hypoglycemia and detecting infants who will require treatment for its prevention.
D000653:Amniotic Fluid / Q000032:analysis*; D001724:Birth Weight; D001786:Blood Glucose / Q000032:analysis* / Q000378:metabolism; D005260:Female; D005947:Glucose / Q000032:analysis / Q000378:metabolism; D006801:Humans; D007003:Hypoglycemia / Q000517:prevention & control; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000517:prevention & control; D007328:Insulin / Q000032:analysis* / Q000378:metabolism; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D011254:Pregnancy in Diabetics
D001786:Blood Glucose; D007328:Insulin; D005947:Glucose