[1H-pyrazolo/1,2-b/phthalazines with anti-inflammatory activity].
The synthesis of forty-one 2,2,6,7-substituted 2,3,5,10-tetrahydro-1H-pyrazolo[1,2-b]phthalazine-1,3-diones A) by reaction of 4,4-di-substituted pyrazolidine-3,5-diones with substituted or unsubstituted alpha,alpha'-dibromoxylene and B) by tetrahydrophthalazine and 2-substituted malonic acid chlorides is described. The antinflammatory activity was tested on carrageenan oedema in comparison with phenylbutazone.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D007202:Indicators and Reagents; D008297:Male; D010653:Phenylbutazone / Q000494:pharmacology; D010793:Phthalazines / Q000138:chemical synthesis*; D011724:Pyridazines / Q000138:chemical synthesis*; D051381:Rats
D000893:Anti-Inflammatory Agents; D007202:Indicators and Reagents; D010793:Phthalazines; D011724:Pyridazines; D010653:Phenylbutazone
1H-pirazolo[1,2-b]ftalazine ad attività antinfiammatoria.