Hypotensive phospholipids. Some stable analogues of Darmstoff.
2-Pentadecyl-4-hydroxymethyl-1,3-dioxolane monosodium phosphate (1) has been shown to exhibit bradycardia and hypotension in rats. It is, however, unstable in aqueous solution. In this study, the stable analogues of 1, 2-pentadecyl-5-hydroxymethyltetrahydrofuran monosodium phosphate (7), and 1-hydroxymethyl-3-pentadecylcyclopentane monosodium phosphate (17) were prepared. These substances exhibited cardiovascular effects similar both qualitively and quantitatively to those elicited by 1 and were stable in solution for about 24 and at least 72 h, respectively.
D000818:Animals; D000959:Antihypertensive Agents; D001794:Blood Pressure / Q000187:drug effects*; D055598:Chemical Phenomena; D002621:Chemistry; D003864:Depression, Chemical; D004148:Dioxolanes / Q000138:chemical synthesis / Q000494:pharmacology*; D004149:Dioxoles / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects*; D010712:Phosphatidic Acids / Q000138:chemical synthesis / Q000494:pharmacology*; D051381:Rats
D000959:Antihypertensive Agents; D004148:Dioxolanes; D004149:Dioxoles; D010712:Phosphatidic Acids; C015775:darmstoff