[Content of growth hormone in the blood in insulin-resistant and insulin-sensitive patients with diabetes mellitus during compensation].
The growth hormone and blood sugar level was determined during compensation in 38 insulin-resistant and in 48 insulin-sensitive patients with diabetes mellitus, on fasting stomach and after an intravenous injection of insulin. The insulin-resistant patients were given insulin in the amount of 100 and more Units per 24 hours at the period of achievement of compensation. In the insulin-sensitive patients with diabetes mellitus during the compensation the growth hormone level in the blood serum on fasting stomach displayed a significant reduction; no significant change occurred in the insulin-resistant patients. On the achievement of normoglycemia a high growth hormone level in the patients with insulin-resistant forms of diabetes mellitus was probably conditioned by disturbance of the adaptation processes, and possibly also by the preservation of decreased glucose metabolism at the cell level. Under these conditions the growth hormone apparently produced a diabetogenic action and prevented stable compensation creating conditions for the preservation of insulin resistance.
D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D003920:Diabetes Mellitus / Q000097:blood* / Q000188:drug therapy; D005260:Female; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D007333:Insulin Resistance; D008875:Middle Aged
D001786:Blood Glucose; D007328:Insulin; D013006:Growth Hormone
Soderzhanie gormona rosta v krovi u insulinorezistentnykh i insulinochuvstvitel'nykh bol'nykh sakharnym diabetom v protssesse kompensatsii.