[On molecular biology of ageing. 12th communication. Glutathione, SH-reagents, metabolism (author's transl)].
1. The significantion of the regulative function of SH-groups in ageing is described comprehensively 2. The redox state of glutathione changes in ageing 3. The activity of SH-enzymes is decreased in old tissues. They are reactivated in vivo and in vitro 4. The decreased protein synthesis in the liver of old rats is stimulated by 2-mercaptoethanol.
D000375:Aging; D000818:Animals; D005978:Glutathione / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008623:Mercaptoethanol / Q000494:pharmacology; D008967:Molecular Biology; D010084:Oxidation-Reduction; D014176:Protein Biosynthesis; D051381:Rats; D013268:Stimulation, Chemical; D013438:Sulfhydryl Compounds / Q000378:metabolism
D013438:Sulfhydryl Compounds; D008623:Mercaptoethanol; D005978:Glutathione
Zur Molekularbiologie des Alterns. 12. Mitteilung: Glutathion und der Einfluss von SH-Reagenzien im Stoffwechsel alternder Zellen.