The accumulation of weakly basic substances in lysosomes and the inhibition of intracellular protein degradation.
D000643:Ammonium Chloride / Q000494:pharmacology; D000818:Animals; D002403:Cathepsins / Q000037:antagonists & inhibitors; D002738:Chloroquine / Q000494:pharmacology; D004247:DNA / Q000096:biosynthesis; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D007700:Kinetics; D007832:Lasalocid / Q000494:pharmacology; D008247:Lysosomes / Q000187:drug effects / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D051381:Rats
D011506:Proteins; D000643:Ammonium Chloride; D002738:Chloroquine; D004247:DNA; D002403:Cathepsins; D007832:Lasalocid