Roquefortine and isofumigaclavine A, alkaloids from Penicillium roqueforti.
Extraction of mycelium from cultures of Penicillium roqueforti (strain CS1) yielded 2 new crystalline metabolites, designated roquefortine and isofumigaclavine A. The structure of roquefortine, the major alkaloid, was established by a combination of chemical transformations and spectroscopic studies. The structure of isofumigaclavine A was determined by spectroscopic and X-ray analysis. Roquefortine possessed neurotoxic properties when injected intraperitoneally in mice and has been detected in 16 out of 16 samples of blue cheese from 7 countries. Isofumigaclavine A has also been found in blue cheese.
D000818:Animals; D001681:Biological Assay; D002611:Cheese; D004873:Ergolines / Q000096:biosynthesis; D013058:Mass Spectrometry; D051379:Mice; D009183:Mycotoxins / Q000096:biosynthesis; D010407:Penicillium / Q000378:metabolism*
D004873:Ergolines; D009183:Mycotoxins