The pharmacokinetic aspects of therapy with psychotropic agents.
This contribution is concerned with a critical appraisal of the concept that plasma levels of psychotropic agents govern their pharmacodynamic action. In this regard, there are at least three problems: 1. identification of the chemical course of reaction between the introduced pharmacon and its resultant metabolites in reference to the totality of the organism and its biochemical reaction pattern; 2. the course of this reaction relative to intra- and interindividual differences; and 3. the influence of the kinetics as a result of concentration diversities, conditioned by different distributing patterns within the organism. Decisive factors here are: mode of application, blood distribution volume, reaction and/or elimination rate, and, finally, interaction of combined drugs.
D000136:Acid-Base Equilibrium; D001798:Blood Proteins / Q000378:metabolism; D004194:Disease / Q000378:metabolism; D004790:Enzyme Induction; D006801:Humans; D007700:Kinetics; D009048:Motor Skills / Q000187:drug effects; D011485:Protein Binding; D011619:Psychotropic Drugs / Q000378:metabolism* / Q000627:therapeutic use; D011955:Receptors, Drug
D001798:Blood Proteins; D011619:Psychotropic Drugs; D011955:Receptors, Drug