Fertility of male rats treated with 15(S)-15-methyl prostaglandin F2 alpha methyl ester-containing silastic implants.
Male Spraque-Dawley rats receiving implants of silicone rubber discs containing 1% or 2% 15(S)-15-methyl prostaglandin F2 alpha methyl ester (15-Me-PGF 2 alpha) or no prostaglandin were tested in successive breeding trials for potency and fertility. One week after implantation, discs containing 1% 15-Me-PGF2 alpha reduced potency and fertility, which returned 2 weeks after implantation. Animals receiving implants of the 2% discs were apparently impotent the 1st week following implantation; potency returned before full fertility returned 11 weeks after implantation.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003307:Copulation; D004343:Drug Implants; D005260:Female; D005298:Fertility / Q000187:drug effects*; D008297:Male; D011247:Pregnancy; D011461:Prostaglandins F, Synthetic / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D012826:Silicone Elastomers
D004343:Drug Implants; D011461:Prostaglandins F, Synthetic; D012826:Silicone Elastomers