Physiological perfusion model for cephalosporin antibiotics I: Model selection based on blood drug concentrations.
Various cephalosporins with different degrees of protein binding were administered to human volunteers. Blood samples were collected as a function of time and were assayed for drug content by a microbiological assay. A pharmacokinetic analysis of the data was performed using a two-compartment model with and without protein binding in the central compartment and a perfusion model. Both the two-compartment model without protein binding and the physiological perfusion model adequately described the blood levels of all three cephalosporins.
D001798:Blood Proteins / Q000378:metabolism; D002511:Cephalosporins / Q000097:blood*; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D010477:Perfusion; D011485:Protein Binding
D001798:Blood Proteins; D002511:Cephalosporins