ADH and related peptides: effect of pre- or posttraining treatment on puromycin amnesia.
The peptide Z-Pro-Leu-Gly-NH2 attenuated puromycin-induced amnesia in mice when administered 5 days prior to training, while arginine vasopressin, lysine vasopressin and cyclo(Leu-Gly), were effective when given 24 hr before training. The activity of all peptides to inhibit puromycin-induced amnesia decreased as the interval after training and before peptide administration increased, suggesting that the peptides influence memory processes rather than generalized arousal mechanisms.
D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology; D001362:Avoidance Learning / Q000187:drug effects; D003515:Cycloleucine / Q000494:pharmacology; D008236:Lypressin / Q000494:pharmacology; D008568:Memory / Q000187:drug effects*; D011939:Mental Recall / Q000187:drug effects*; D051379:Mice; D010455:Peptides / Q000494:pharmacology; D011292:Premedication; D011691:Puromycin / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D012153:Retention, Psychology / Q000187:drug effects; D014667:Vasopressins / Q000494:pharmacology*
D010455:Peptides; D003515:Cycloleucine; D014667:Vasopressins; D001127:Arginine Vasopressin; D011691:Puromycin; D008236:Lypressin