Optimal phenytoin therapy: a new technique for individualizing dosage.
A simple, new technique (the direct linear plot) for predicting steady-state serum phenytoin concentrations is described. Although no calculations are required, reliable estimates (comparable with those derived by computer) of the Michaelis-Menten parameters can be readily determined and used graphically to predict the individualized dose required to achieve a desired serum concentration.
D004305:Dose-Response Relationship, Drug; D006801:Humans; D008433:Mathematics; D008954:Models, Biological; D010672:Phenytoin / Q000008:administration & dosage* / Q000097:blood
D010672:Phenytoin