Inactivation of human interferon by body fluids.
We have shown almost all samples of serum, saliva, cerebrospinal fluid, fecal extract, bile or urine tested contain a substance or substances capable of inactivating human interferon at normal body temperature. This adverse effect appears to be greater for fibroblast interferon-induced by either polynucleotides or viruses, than for leukocyte interferon induced by viruses. These results have a number of implications for the clinical utilization of this natural antiviral substance.
D001826:Body Fluids / Q000378:metabolism*; D005347:Fibroblasts / Q000276:immunology; D006801:Humans; D007372:Interferons / Q000037:antagonists & inhibitors* / Q000096:biosynthesis / Q000302:isolation & purification / Q000378:metabolism; D007962:Leukocytes / Q000276:immunology; D009928:Organ Specificity; D011070:Poly I-C / Q000494:pharmacology; D014780:Viruses / Q000276:immunology
D007372:Interferons; D011070:Poly I-C