Muscular dystrophy: inhibition of degeneration in vivo with protease inhibitors.
The protease inhibitors leupeptin and pepstatin were used in vivo in genetically dystrophic chickens to determine their effects on the histological and biochemical changes observed in this disease. These compounds appear to delay the degeneration of muscle tissue which is characteristic of this disorder and thus may have potential therapeutic value in the treatment of muscular dystrophy.
D000818:Animals; D002645:Chickens; D003402:Creatine Kinase / Q000097:blood; D007976:Leupeptins / Q000627:therapeutic use*; D009132:Muscles / Q000473:pathology; D009137:Muscular Dystrophy, Animal / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D009842:Oligopeptides / Q000627:therapeutic use*; D010436:Pepstatins / Q000627:therapeutic use*
D007976:Leupeptins; D009842:Oligopeptides; D010436:Pepstatins; D003402:Creatine Kinase