Propranolol for the control of belligerent behavior following acute brain damage.
The belligerence of 7 patients who had suffered an acute brain insult was effectively controlled by propranolol in doses of 60 to 320 mg per day. Of the 7 patients, 3 were treated in the acute stage after a stroke, a severe closed head injury, and a gunshot wound of the brain, respectively. A chronic postconcussion syndrome associated with chronic irritability was present in 2, and 2 were not chronically irritable but suffered from intermittent attacks of explosive rage in response to minor irritations. In all instances the belligerent behavior was controlled without inducing general sedation.
D000328:Adult; D000374:Aggression / Q000187:drug effects*; D001924:Brain Concussion / Q000150:complications; D001930:Brain Injuries / Q000150:complications; D002561:Cerebrovascular Disorders / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011433:Propranolol / Q000008:administration & dosage / Q000627:therapeutic use*; D014948:Wounds, Gunshot / Q000150:complications
D011433:Propranolol