Immunogenetics of Lennox-Gastaut syndrome: search for LD determinants as genetic markers of the syndrome.
In a previous work we demonstrated a strong association between HLA-B7 and the susceptibility to the Lennox-Gastaut syndrome. In this work we report some preliminary results obtained performing one-way mixed lymphocyte cultures in vitro between 15 unrelated children showing the typical EEG and clinical patterns of the syndrome. The same children were also tested against unrelated control cells from healthy donors. The low stimulation displayed by Lennox-Gastaut patients between them as compared with the higher stimulation found in patients/controls and controls/controls comparisons suggests the existence of an LD allele which may be associated with the disease.
D000483:Alleles; D002648:Child; D004827:Epilepsy / Q000276:immunology*; D006680:HLA Antigens / Q000032:analysis*; D006801:Humans; D007108:Immune Tolerance; D013577:Syndrome
D006680:HLA Antigens