Induced chronic intravascular coagulation in dogs.
When an emulsion of dog brain thromboplastin was infused continuously into dogs for 1--4 weeks only platelets and factor XI were consistently depressed. The remaining clotting factors fell in a dose-dependent fashion but there was a tendency toward recovery despite continued infusion of thromboplastin. Fibrinogen and factor V were unique in that with weaker emulsions of thromboplastin, they often rose without a preliminary fall.
D000818:Animals; D002908:Chronic Disease; D004211:Disseminated Intravascular Coagulation / Q000209:etiology*; D004285:Dogs; D005169:Factor VIII; D005340:Fibrinogen; D006493:Heparin / Q000494:pharmacology; D010978:Platelet Factor 4; D011516:Prothrombin; D013925:Thromboplastin / Q000494:pharmacology
D010978:Platelet Factor 4; D011516:Prothrombin; D005169:Factor VIII; D005340:Fibrinogen; D006493:Heparin; D013925:Thromboplastin