Hemopyrrole and kryptopyrrole are absent from the urine of schizophrenics and normal persons.
We describe a method for detecting hemopyrrole and kryptopyrrole in urine, with a detection limit of 100 mug/liter (1 part in 10(7)). Urine is thoroughly extracted with methylene chloride and the extract is concentrated and examined by gas chromatography and gas chromatography-mass spectrometry. No hemopyrrole or kryptopyrrole could be detected in 52 samples, from 17 controls, 29 schizophrenics, and six persons with acute intermittent porphyria.
D002849:Chromatography, Gas; D006801:Humans; D013058:Mass Spectrometry; D008722:Methods; D011164:Porphyrias / Q000652:urine; D011758:Pyrroles / Q000138:chemical synthesis / Q000652:urine*; D012559:Schizophrenia / Q000652:urine*
D011758:Pyrroles; C016485:hemopyrrole; C011891:kryptopyrrole