Infrequency of urinary excretion of beta-aminoisobutyric acid by healthy humans.
Urinary beta-aminoisobutyric acid (BAIB) levels were measured by modified ion-exchange chromatography. Daily BAIB levels are reported for a group of apparently healthy individuals, a subject with infective hepatitis and two human genetic variants who were high "excretors" of BAIB. The frequency of high "excretors" of BAIB was found using low-voltage paper electrophoresis. The frequency among 403 male European subjects was 5 (1.2%) and lower than previous estimates in the United Kingdom. The percentage recovery of fed BAIB suggests that Oriental "excretors" may have a different type of genetic lesion from non-Oriental "excretors". The clinical usefulness of urinary BAIB assays and qualitative screening is reviewed.
D000293:Adolescent; D000328:Adult; D000621:Aminoisobutyric Acids / Q000652:urine*; D002852:Chromatography, Ion Exchange; D004590:Electrophoresis, Paper; D005260:Female; D006525:Hepatitis, Viral, Human / Q000652:urine; D006801:Humans; D008297:Male; D008722:Methods; D008875:Middle Aged; D044469:Racial Groups; D013997:Time Factors
D000621:Aminoisobutyric Acids