[Endogenous pyrogen formation by bone marrow cells].
The cells of the rabbit bone marrow produced endogenous pyrogen in response to stimulation with bacterial lipopolysaccharide. Incubation of the cells in medium No 199 containing a 15% homologous serum is optimal for the release of pyrogen. It is supposed that the cells of the bone marrow take part in the formation of endgenous pyrogen and in the mechanism of pyrexia in the organism.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000378:metabolism*; D001854:Bone Marrow Cells; D005260:Female; D005334:Fever / Q000378:metabolism; D066298:In Vitro Techniques; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D011135:Polysaccharides, Bacterial; D011749:Pyrogens / Q000096:biosynthesis* / Q000494:pharmacology; D011817:Rabbits
D008070:Lipopolysaccharides; D011135:Polysaccharides, Bacterial; D011749:Pyrogens
Obrazovanie éndogennogo pirogena kletkami kostnogo mozga.