Thermoregulatory effects on the sheep of intracerebroventricular injections of L-glutamic acid.
L-glutamic acid injected in doses of 200--1000 n moles . kg-1 into the cerebral ventricles of sheep had dose-dependent thermoregulatory effects: an increase in heat production and/or a decrease in respiratory frequency, and a rise in rectal temperature. A dose of 800 nmoles . kg-1 had effects comparable with those of a similar injection of 3 nmoles . kg-1 carbamylcholine.
D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005971:Glutamates / Q000008:administration & dosage / Q000494:pharmacology*; D007276:Injections, Intraventricular; D012756:Sheep
D005971:Glutamates