Urinary, plasma and adrenal tissue steroids in a male patient with Cushing's syndrome due to adrenal carcinoma.
The dynamics of urinary and plasma steroids (CPB and RIA) were simultaneously studied in a 36-yr-man with Cushing's syndrome due to adrenal carcinoma. The markedly increased basal excretion of 5-pregnenetriol, PG, PGT, DHA, THS and corticosteroids with nonsignificant changes during the endocrine tests decreased to normal levels after tumour removal. The basal low level of plasma testosterone, with nonsignificant changes during the endocrine tests, rose progressively after surgery. The steroid content of adrenal carcinoma tissue determined by CPB and RIA after LH-20-Sephadex CC separation revealed important proportion of unconjugated 17-OH-P.
D000310:Adrenal Gland Neoplasms / Q000378:metabolism*; D000311:Adrenal Glands / Q000378:metabolism*; D000328:Adult; D003480:Cushing Syndrome / Q000378:metabolism*; D003907:Dexamethasone; D006801:Humans; D008297:Male; D008797:Metyrapone; D013256:Steroids / Q000097:blood / Q000378:metabolism* / Q000652:urine
D013256:Steroids; D003907:Dexamethasone; D008797:Metyrapone