A new topical hemostatic agent in gynecologic surgery.
Experiences with a topical hemostatic agent, microfibrillar collagen (MFC), material made from beef hide dermis are recounted. Topical hemostasis is facilitated by virtue of its fibrillar structure forming a sticky matrix for platelet aggregation. The material was used in women undergoing cervical conization to determine its absorption at hysterectomy 6 weeks later. In another group, it was used as the sole hemostatic agent at conization and compared with a control group in which conventional sutures were used. A larger group who underwent abdominal hysterectomy allowed comparison between MFC on the bladder muscularis and conventional suture ligature in terms of blood loss, operating time success of method used, and complications.
D000287:Administration, Topical; D000328:Adult; D000818:Animals; D002417:Cattle; D002584:Cervix Uteri / Q000601:surgery; D003094:Collagen / Q000008:administration & dosage* / Q000009:adverse effects / Q000378:metabolism; D005260:Female; D005831:Genital Diseases, Female / Q000601:surgery*; D006488:Hemostasis, Surgical; D006490:Hemostatics / Q000008:administration & dosage*; D006801:Humans; D007044:Hysterectomy; D013537:Sutures; D001743:Urinary Bladder
D006490:Hemostatics; D003094:Collagen