[Derivatives of 3-hydrazinopyridazine. II. Synthesis and antihypertensive activity of new 3-hydrazino-6-monoalkylaminopyridazines].
The synthesis of some 3-hydrazino-6-monoalkylaminopyridazines (VIII) by reaction of 3,6-dichloropyridazine with various N-monoalkylbenzylamines, followed by reaction with hydrazine and final debenzylation in an acidic medium, is described. The new compounds were evaluated as antihypertensive agents and exhibited the same or higher activity than hydralazine, but lower activity than propildazine (ISF 2123).
D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis*; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D055598:Chemical Phenomena; D002621:Chemistry; D051379:Mice; D011724:Pyridazines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats
D000959:Antihypertensive Agents; D011724:Pyridazines
Derivati della 3-idrazinopiridazina. Nota II - Sintesi e attività antiipertensiva di nuove 3-idrazino-6-monoalchilaminopiridazine.