Benign intracranial hypertension after minocycline therapy.
A case is reported of a young girl who developed benign intracranial hypertension, with severe bilateral papiledema and a left sixth cranial nerve palsy, after minocylcine therapy. This drug is a semisynthetic tetracycline which has proven to pass into the CSF more effectively and to have a greater lipoid solubility than the other antibiotics of the same group.
D000010:Abducens Nerve / Q000187:drug effects; D000293:Adolescent; D005260:Female; D006801:Humans; D007427:Intracranial Pressure / Q000187:drug effects*; D008911:Minocycline / Q000009:adverse effects* / Q000627:therapeutic use; D010211:Papilledema / Q000139:chemically induced*; D010243:Paralysis / Q000139:chemically induced*; D011559:Pseudotumor Cerebri / Q000139:chemically induced*; D013754:Tetracyclines / Q000009:adverse effects*
D013754:Tetracyclines; D008911:Minocycline