Hemorrhagic cystitis with MOPP therapy.
After 12 cycles of MOPP therapy for Hodgkin's Disease, an adolescent black male developed hemorrhagic cystitis, which clinically and histologically was similar to that induced by cyclophosphamide. At that time he had a normal platelet count and had never been irradiated below the diaphram. The markedly contracted bladder returned to normal approximately one month following cessation of therapy.
D002648:Child; D003520:Cyclophosphamide / Q000009:adverse effects; D003556:Cystitis / Q000139:chemically induced*; D004359:Drug Therapy, Combination; D006417:Hematuria / Q000139:chemically induced*; D006689:Hodgkin Disease / Q000188:drug therapy; D006801:Humans; D008297:Male; D008466:Mechlorethamine / Q000009:adverse effects*; D011241:Prednisone / Q000009:adverse effects*; D011344:Procarbazine / Q000009:adverse effects*; D012075:Remission, Spontaneous; D014750:Vincristine / Q000009:adverse effects*
D011344:Procarbazine; D008466:Mechlorethamine; D014750:Vincristine; D003520:Cyclophosphamide; D011241:Prednisone