Thymus cell variations in AKR leukemia.
The thymus cells from spontaneous and 1st generation AKR leukemic mice were investigated, using electronic cell-volume distributions. The growth pattern of thymus cells in the mice with transplanted leukemic cells varied with the type of donor cells injected. After the transplantation of leukemic cells into 2 month-old recipients, the cortex of thymus decreased in size and medulla of thymus enlarged. The thymus underwent atrophy next, followed by a proliferation of the large-sized cells (greater than channel 40, 136 micrometer3). The electronic cell-volume distributions of the thymus cells from the spontaneous leukemic mice encompass the distributions of thymus cells during the growth of the transplanted leukemia.
D000818:Animals; D001853:Bone Marrow / Q000473:pathology; D007942:Leukemia, Experimental / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology; D051379:Mice; D008806:Mice, Inbred AKR; D009368:Neoplasm Transplantation; D013154:Spleen / Q000473:pathology; D013950:Thymus Gland / Q000473:pathology*; D014184:Transplantation, Homologous