Ratio of late to early radionuclide uptake: a method for distinguishing osteoporosis from osteomalacia in animal models.
The ration of late to early uptake of several radionuclides was examined as a method for distinguishing states of abnormal bone metabolism. Nutritional osteoporosis (secondary hyperparathyroidism) and osteomalacia were produced in young rats and compared to a control group. The ratio of early (3-6 hrs.) to late (4-6 days) uptake of barium-131, nitrate, indium-111 EDTMP, and lead-203 were studied, as was that of strontium-85 chloride, a calcium analogue. Ratios of late to early uptake were found to distinguish osteomalacia from osteoporosis in the models when strontium-85 or barium-131 were used. Barium-131 may be a clinically useful alternative to strontium-85 in the evaluation of metabolic bone disease due to its shorter half-life and lower radiation dose.
D000818:Animals; D001464:Barium; D003937:Diagnosis, Differential; D007204:Indium; D007854:Lead; D010018:Osteomalacia / Q000000981:diagnostic imaging*; D010024:Osteoporosis / Q000000981:diagnostic imaging*; D011829:Radiation Dosage; D011868:Radioisotopes; D011877:Radionuclide Imaging; D051381:Rats; D013326:Strontium Radioisotopes; D013752:Tetracycline; D013997:Time Factors
D011868:Radioisotopes; D013326:Strontium Radioisotopes; D007204:Indium; D001464:Barium; D007854:Lead; D013752:Tetracycline