Chemotherapy of human nervous system tumors: influence on cerebrospinal fluid sterols.
The cerebrospinal fluid levels of cholesterol, desmosterol, and the ratio 100 D:C taken from a study of 59 patients are reported. The patients, who had tumors of the nervous system, underwent neurosurgery, radiotherapy, and chemotherapy with 1,3-bis(2-chloroethyl)-1-nitrosourea or 1-(2-chlororethyl)-3-cyclohexyl-1-nitrosourea. The relationships among the levels of these three parameters and the clinical and neuroradiologic evolution are discussed.
D000328:Adult; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001932:Brain Neoplasms / Q000134:cerebrospinal fluid* / Q000628:therapy; D002330:Carmustine / Q000627:therapeutic use; D002784:Cholesterol / Q000134:cerebrospinal fluid*; D003897:Desmosterol / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D008130:Lomustine / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged
D000970:Antineoplastic Agents; D003897:Desmosterol; D008130:Lomustine; D002784:Cholesterol; D002330:Carmustine