Influence of the thymus on the incidence of secondary and parabiotic disease.
The secondary disease in P leads to F1 strain combination depends upon the immune status of both partners. It is most clearly expressed if both donors and recipients are immunologically crippled by thymectomy and irradiation. Conspicuous reduction in the immune potential of parental parabionts induced by thymectomy and irradiation displayed their marked incidence of parabiotic death.
D000818:Animals; D004194:Disease / Q000209:etiology*; D005260:Female; D007109:Immunity / Q000528:radiation effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010227:Parabiosis / Q000528:radiation effects; D011830:Radiation Effects; D013934:Thymectomy; D013950:Thymus Gland / Q000276:immunology / Q000502:physiology* / Q000528:radiation effects