Antibody-induced suppression of the fifth component of complement in mice.
We have shown that administration of anti-C5 antibody to newborn mice heterozygous for C5 deficiency can suppress C5 levels for prolonged periods. This is analogous to antibody-induced immunoglobulin allotype and idiotype suppression. Only certain sources of anti-C5 are effective in suppression. Of the three antisera extensively tested in (SWR x RIII)F1 hybrids, A/He anti-RIII was the most effective, SWR anti-RIII was less effective, and SWR anti-DBA/1 was ineffective. Only certain strain combinations of F1 hybrids are susceptible to C5 suppression. C5 suppression was seen with (SWR x RIII)F1 hybrids but not (SWR x DBA/1)F1 hybrids. Kinetics of C5 suppression suggest a requirement for an active, ongoing process in the maintenance of low C5 levels.
D000818:Animals; D000831:Animals, Newborn; D000906:Antibodies; D003182:Complement C5 / Q000037:antagonists & inhibitors*; D005260:Female; D006579:Heterozygote; D006824:Hybridization, Genetic; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D008815:Mice, Inbred Strains
D000906:Antibodies; D003182:Complement C5