Anti leukemia activity (Dunning ascitic) of 6-mercaptopurine and its metallo complexes in rats.
Six-mercaptopurine and its Pt, Pd and Bi complexes were used at various dosage levels to treat Dunning ascitic leukemia in rats. Significant anticarcinogenic activity was found in all compounds with toxicity apparent at the highest dosage level of all but the platinum compound.
D000818:Animals; D001729:Bismuth / Q000009:adverse effects / Q000627:therapeutic use*; D007942:Leukemia, Experimental / Q000188:drug therapy*; D015122:Mercaptopurine / Q000009:adverse effects / Q000627:therapeutic use*; D010165:Palladium / Q000009:adverse effects / Q000627:therapeutic use*; D010984:Platinum / Q000009:adverse effects / Q000627:therapeutic use*; D051381:Rats; D011916:Rats, Inbred F344; D013997:Time Factors
D010984:Platinum; D010165:Palladium; D015122:Mercaptopurine; D001729:Bismuth