[Change in the antinociceptive effect occurring on stimulation of the midbrain under the action of analgesics and tranquilizers].
It was shown in chronic experiments on cats that analgetics in subanalgetic doses not only revealed the antinociceptive effect under subthreshold stimulation of the midbrain, but also enhanced the analgetic effect of the central stimulation. The tranquilizers promoted only the analgetic action under the subthreshold stimulation of the midbrain. Possible causes of different effect of the drugs under study are discussed.
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D002415:Cats; D003791:Dental Pulp Test; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004558:Electric Stimulation; D008636:Mesencephalon / Q000187:drug effects*; D009619:Nociceptors / Q000187:drug effects*; D010146:Pain / Q000188:drug therapy / Q000503:physiopathology; D014149:Tranquilizing Agents / Q000494:pharmacology*
D000700:Analgesics; D014149:Tranquilizing Agents
Izmenenie antinotsiteptivnogo éffekta, voznikaiushchego pri stimuliatsii srednego mozga, pod vliianiem anal'getikov i trankvilizatorov.