Adrenergic and nonadrenergic activation of isolated human renal veins of normotensive and hypertensive patients.
In human renal venous strips from normotensive and hypertensive patients, adrenergic- and nonadrenergic-induced contractions were elicited. The maximal amplitude of contractions remained unchanged whatever the mode of activation. However, in the hypertensive group the forces generated reached only about 20% of those in the normotensive group. Furthermore, preparations from hypertensive patients showed a reduced sensitivity for noradrenaline: the ED50 was shifted from 0.13 +/- 0.03 to 0.66 +/- 0.19 microgram/ml (p less than 0.01). This reduced sensitivity is discussed in connection with the pathogenesis of hypertension.
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D006801:Humans; D006977:Hypertension, Renal / Q000503:physiopathology*; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects* / Q000294:innervation; D009638:Norepinephrine / Q000494:pharmacology*; D011188:Potassium / Q000494:pharmacology; D011941:Receptors, Adrenergic / Q000502:physiology; D012082:Renal Veins / Q000187:drug effects* / Q000294:innervation
D011941:Receptors, Adrenergic; D011188:Potassium; D009638:Norepinephrine