[Pharmacokinetic study of intravenous furosemide in nephrotic syndrome in children].
The pharmacokinetics and pharmacological effect of intravenous furosemide (F) (2 mg/kg body weight) were studied in 12 children with the nephrotic syndrome with or without renal failure (R.F.). The concentration of F in blood and urine was determined by a new spectrophotometric method. In the nephrotic syndrome alone, the rate of renal excretion was increased (increased slope of the pharmacokinetic curve, decreased t 1/2), which may be due to a decrease in the fraction bound to plasma albumin. In children with the nephrotic syndrome and renal failure, the decrease in the renal excretion of F was related to the degree of renal failure. In normal children the mean F clearance is 296. In patients with N.S. alone the clearance is greatly increased (X = 377) and in N.S. with R.F. it is reduced (0.17-90). The possible mechanisms and therapeutic implications of the results are discussed.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D005665:Furosemide / Q000008:administration & dosage / Q000378:metabolism* / Q000627:therapeutic use; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D009318:Natriuresis / Q000187:drug effects; D009404:Nephrotic Syndrome / Q000188:drug therapy*; D013997:Time Factors
D005665:Furosemide
Etude pharmacocinetique du furosemide intraveineux dans les syndromes nephrotiques de l'enfant.