Globin synthesis by nucleated erythroid cells in chronic glomerulonephritis.
Globin synthesis rate (GSR) by nucleated erythroid cells was investigated in 40 patients suffering from chronic glomerulonephritis, in 24 subjects with other renal diseases and in 8 healthy controls. GSR was reduced in nephrogenic anemia; moreover, this reduction took place in a few patients without anemia. The correlation between GSR and some characteristics of erythropoiesis was examined. The supression of GSR is probably one of the important causes of nephrogenic anemia.
D000208:Acute Disease; D002908:Chronic Disease; D004900:Erythroblasts / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D005914:Globins / Q000096:biosynthesis*; D005921:Glomerulonephritis / Q000097:blood*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood; D008297:Male
D005914:Globins