The oestrogenised chick as an experimental model for fatty liver-haemorrhagic syndrome in the fowl.
A syndrome resembling fatty liver-haemorrhagic syndrome in laying hens was reproduced in six- to seven-week-old chickens by injecting oestradiol-17beta-dipropionate intramuscularly (total dose 20-50 mg/kg). The degree of hepatic steatosis and the severity and extent of haemorrhage from the liver varied with the dose and the results suggested a pathogenic relationship between the two conditions. There was no evidence of reticulolysis in the liver. When food was withdrawn for 24 h after the last injection there was a dramatic fall in the haemorrhage score and a reduction in the lipid content of the liver.
D000818:Animals; D002645:Chickens; D004958:Estradiol; D005234:Fatty Liver / Q000139:chemically induced / Q000662:veterinary*; D005260:Female; D006470:Hemorrhage / Q000139:chemically induced / Q000662:veterinary*; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism; D011201:Poultry Diseases / Q000139:chemically induced*; D013577:Syndrome / Q000662:veterinary
D004958:Estradiol