Anaphylaxis to protamine sulfate mediated by a complement-dependent IgG antibody.
Anaphylactoid reactions to protamine sulfate have been attributed to its capacity for nonimmunologic mast cell degranulation and/or complement consumption. In the current study, evidence is presented for the occurrence of an immunologic anaphylactic reaction mediated by a complement-dependent IgG skin-sensitizing antibody. A retrospective study of blood component donors given protamine for heparin neutralization revealed that prior exposure to protamine is associated with increased risk of adverse reaction to the drug.
D000328:Adult; D000707:Anaphylaxis / Q000139:chemically induced*; D000906:Antibodies; D003165:Complement System Proteins / Q000494:pharmacology*; D006801:Humans; D007074:Immunoglobulin G; D008297:Male; D011479:Protamines / Q000008:administration & dosage / Q000009:adverse effects; D012882:Skin Tests; D013997:Time Factors
D000906:Antibodies; D007074:Immunoglobulin G; D011479:Protamines; D003165:Complement System Proteins