Effect of various treatments on toxicity of inhaled vinylidene chloride.
The toxicity of vinylidene chloride (VDC) was studied in mice and rats exposed to various concentrations of the vapors for 23 hr/day. In addition, the ability of various treatments to alter parameters of toxicity was evaluated. Mice were more sensitive than rats both to the acute lethal and hepatotoxic effects of VDC. Disulfiram treatment reduced the acute lethal and hepatotoxic effects of inhaled VDC and reduced the levels of covalent bound radioactivity in the liver and kidney after the intraperitoneal administration of 14C-VDC. Treatment with diethyldithiocarbamate and thiram also protected mice from the acute lethal effects of VDC.
D000603:Amino Acids, Sulfur / Q000627:therapeutic use; D000818:Animals; D001205:Ascorbic Acid / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D004000:Dichloroethylenes / Q000633:toxicity*; D004112:Dimercaprol / Q000627:therapeutic use; D004221:Disulfiram / Q000627:therapeutic use; D004781:Environmental Exposure; D005260:Female; D006843:Hydrocarbons, Chlorinated / Q000633:toxicity*; D007928:Lethal Dose 50; D008099:Liver / Q000187:drug effects; D008297:Male; D051379:Mice; D010643:Phenoxybenzamine / Q000627:therapeutic use; D011335:Proadifen / Q000627:therapeutic use; D051381:Rats; D013045:Species Specificity; D013859:Thiocarbamates / Q000627:therapeutic use; D014810:Vitamin E / Q000627:therapeutic use
D000603:Amino Acids, Sulfur; D004000:Dichloroethylenes; D006843:Hydrocarbons, Chlorinated; D013859:Thiocarbamates; D004112:Dimercaprol; D010643:Phenoxybenzamine; D014810:Vitamin E; D011335:Proadifen; D001205:Ascorbic Acid; D004221:Disulfiram