In vitro testing of an indirect mutagen (cyclophosphamide) with human leukocyte cultures. Activation by a non-enzymatic hydroxylation system (Udenfriend system).
D001205:Ascorbic Acid / Q000494:pharmacology; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D003520:Cyclophosphamide / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D006900:Hydroxylation; D007854:Lead / Q000494:pharmacology; D007962:Leukocytes / Q000378:metabolism* / Q000648:ultrastructure; D009153:Mutagens
D009153:Mutagens; D007854:Lead; D003520:Cyclophosphamide; D001205:Ascorbic Acid