alpha-Helix-double helix interaction shown in the structure of a protamine-transfer RNA complex and a nucleoprotamine model.
Single crystal X-ray diffraction and circular dichroism studies of protamine binding to a tRNA suggest that the protamine molecule changes its conformation from a random coil to a structure containing a helices on binding to tRNA, and that alpha-helical segment(s) of protamine bind approximately along a shallow groove of a double-helical portion of ttrna. based on these observations, a structural model for nucleoprotamine is proposed.
D000595:Amino Acid Sequence; D002942:Circular Dichroism; D009690:Nucleic Acid Conformation; D011479:Protamines; D011485:Protein Binding; D011487:Protein Conformation; D012343:RNA, Transfer; D014961:X-Ray Diffraction
D011479:Protamines; D012343:RNA, Transfer