Studies on the in vivo-action of leupeptin on the nitrogen retention in rats.
A daily s.c. injection of 0.5 mg leupeptin for 7 days does not influence the digestibility of food-N but seems to improve the N-retention. A daily injection of 1.0 mg leupeptin for 14 days is without influence on the digestibility of N, too, but the N-retention was decreased. At this leupeptin level the half-lives of intestinal proteins were prolonged. The data indicate the possibility to influence the N-retention using leupeptin.
D000818:Animals; D004044:Dietary Proteins; D006207:Half-Life; D007420:Intestine, Large / Q000378:metabolism; D007421:Intestine, Small / Q000378:metabolism; D007700:Kinetics; D007976:Leupeptins / Q000494:pharmacology*; D009584:Nitrogen / Q000378:metabolism*; D009842:Oligopeptides / Q000494:pharmacology*; D011506:Proteins / Q000378:metabolism*; D051381:Rats
D004044:Dietary Proteins; D007976:Leupeptins; D009842:Oligopeptides; D011506:Proteins; D009584:Nitrogen