[Optimation of postoperative prophylaxis of thrombosis in gynaecology (author's transl)].
The prophylactic effect of heparin dihydroergotamine, the combination of these two (Heparin-Dihydergot)  and acetylsalicylic-acid in the prevention of deep vein thrombosis was investigated in a prospective randomized clinical trial involving 454 patients. Evidence of thrombosis was detected by the 125I-fibrinogen-uptake-test in 22 out of 75 patients (29.3%) in the control group. The application of 2 x 0.5 mgDHE or 2 x 5000 IU of heparin reduced the incidence of deep vein thrombosis to 7%, which is statistically significant. After simultaneous prophylaxis with both drugs the incidence dropped to 2%. The combined use of DHE and heparin may be considered the best prophylactic regimen available for lowering postoperative DVT. After application of 3 x 0.5 g of ASS frequency of DVT decreased only to 15.3% and shows poor prophylactic efficacy.
D000328:Adult; D001241:Aspirin / Q000627:therapeutic use*; D004087:Dihydroergotamine / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005831:Genital Diseases, Female / Q000601:surgery; D006493:Heparin / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D011183:Postoperative Complications; D011446:Prospective Studies; D013924:Thrombophlebitis / Q000517:prevention & control*
D004087:Dihydroergotamine; D006493:Heparin; D001241:Aspirin
Optimierung der postoperativen Thromboseprophylaxe in der Gynäkologie. Ein Vergleich von Heparin, Dihydroergotamin, ihrer Kombination und Azetylsalizylsäure.