A comparison of the PAS-reaction in the dermis of diabetic and non-diabetic humans.
Dermopathy is a part of the diabetic syndrome that decreases the solubility of dermal collagen. In the present study, the PAS-reactive component of collagen has been analysed in diabetic and non-diabetic human dermis by photographic densitometry. The PAS-reaction was significantly lower in diabetics than non-diabetics, and age seemed to be of no consequence. The results are interpreted to indicate a decrease in collagen-associated sugar residues in diabetics.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging; D003094:Collagen / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D010503:Periodic Acid-Schiff Reaction; D012867:Skin / Q000254:growth & development / Q000378:metabolism*
D003094:Collagen