[Contribution of individual structural components to stabilization of the secondary structure of double-helical polynucleotides].
Contributions of individual structural components of the double-helical polynucleotide to the stabilization of its secondary structure have been studied. The energy of intramolecular interactions was calculated by the method of atom-atom potentials. Sections of the energy function were constructed according to the parameters determining mutual location of base pairs with the optimal conformation of ribose-phosphate backbone in the points close to A- and B-forms of DNA. A complicated nature of the contribution of different structural components of the polynucleotide to its stabilization was revealed by means of different parameters. Relationships between the change of conformational parameters corresponding to optimal values of energy for A- and B-families of nucleic acids were found.
D004247:DNA; D009690:Nucleic Acid Conformation; D011089:Polydeoxyribonucleotides
D011089:Polydeoxyribonucleotides; D004247:DNA
Issledovanie vklada otdel'nykh strukturnykh komponentov v stabilizatsiiu vtorichnoĭ struktury dvuspiral'nogo polinukleotida.