Guillain-Barré syndrome: a 42-year epidemiologic and clinical study.
The central medical-records linkage system at the Mayo Clinic for the population of Olmsted County, Minnesota, provided the necessary data resource for the identification and follow-up of virtually all diagnosed cases of the Guillain--Barré syndrome over a period of 42 years. During this time, a total of 40 Olmsted County residents had clinical signs and symptoms of the disease. The mean annual incidence rate was 1.7 per 100,000 population. There was a significantly higher incidence rate (P less than 0.01) among patients 40 years of age and older. In four patients malignancies developed; however, the occurrence of the Guillain-Barré syndrome had no significant effect on survivorship in these patients. A case-control comparison of suggested etiologic factors supports the view that there is a significant association between antecedent infections and the Guillain-Barré syndrome.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007239:Infections / Q000150:complications; D008297:Male; D008875:Middle Aged; D008910:Minnesota; D009369:Neoplasms / Q000150:complications; D011128:Polyradiculopathy / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology