Inhibition of mast cell population by L-glutamine in aspirin-induced ulceration in rat stomach.
The effects of an amino acid L-glutamine on aspirin-induced gastric lesions as well as on the mast cell population were studied in rats. L-glutamine had a pronounced inhibitory effect on gastric lesions produced by oral aspirin administration. Aspirin-induced increase in the mast cell population of the stomach was also prevented. Parenteral administration of aspirain did not produce any significant damage to the gastric mucosa.
D000818:Animals; D001241:Aspirin; D002452:Cell Count / Q000187:drug effects; D003864:Depression, Chemical; D005973:Glutamine / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008407:Mast Cells / Q000187:drug effects*; D051381:Rats; D013270:Stomach / Q000473:pathology; D013276:Stomach Ulcer / Q000139:chemically induced / Q000473:pathology* / Q000517:prevention & control
D005973:Glutamine; D001241:Aspirin