Mammary tumors induced in rats by adriamycin and daunomycin.
The two anthracycline antitumor antibiotics, Adriamycin and daunomycin (DM), induced a high incidence of mammary tumors, both fibroadenomas and adenocarcinomas, in female rats that received a single i.v. dose, thus confirming previous results. The incidence of DM-induced adenocarcinomas increased with the dose of the drug, whereas the incidence of Adriamycin-induced adenocarcinomas showed a plateau at 5 mg/kg and above. Adriamycin- and DM-induced fibroadenomas showed a peak at lower doses (about 5 to 6 mg/kg). With the highest DM dose (12.5 mg/kg) used, there was a slight prevalence of adenocarcinomas over fibroadenomas.
D000230:Adenocarcinoma / Q000139:chemically induced; D000232:Adenofibroma / Q000139:chemically induced; D000818:Animals; D003630:Daunorubicin / Q000008:administration & dosage / Q000633:toxicity*; D004317:Doxorubicin / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced*; D051381:Rats
D004317:Doxorubicin; D003630:Daunorubicin