Muscle disease in progressive systemic sclerosis: diagnostic and therapeutic considerations.
Upon careful examination, 23 of 24 patients with progressive systemic sclerosis (PSS) were found to have abnormalities of muscle. Nineteen patients presented a homogenous pattern of muscle abnormalities, which untreated was associated with a stable course ("simple myopathy"). Three patients demonstrated inflammatory muscle disease indistinguishable from polymyositis while a fourth patient developed marked weakness associated with a generalized neuropathic process. Muscle enzymes, electromyogram, and muscle biopsy permitted distinction among the different muscle disorders, a distinction that could have prognostic and therapeutic importance.
D000328:Adult; D000368:Aged; D001706:Biopsy; D003402:Creatine Kinase / Q000097:blood; D003882:Dermatomyositis / Q000201:enzymology / Q000473:pathology; D004576:Electromyography; D005260:Female; D005634:Fructose-Bisphosphate Aldolase / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000473:pathology; D009135:Muscular Diseases / Q000150:complications* / Q000201:enzymology / Q000473:pathology; D009220:Myositis / Q000201:enzymology / Q000473:pathology; D012595:Scleroderma, Systemic / Q000150:complications* / Q000201:enzymology / Q000473:pathology
D003402:Creatine Kinase; D005634:Fructose-Bisphosphate Aldolase