Naturally occurring low molecular weight inhibitors of neutral proteinases from PMN-granulocytes and of kallikreins.
Human mucous secretions contain low molecular weight (Mr approximately 11,000) acid-stable inhibitors directed against elastase and cathepsin G from PMN-granulocytes. Important biochemical properties of these inhibitors are presented and their possible biological function is discussed. An inhibitor of glandular and plasma kallikreins preventing kinin-liberation from kininogen but not ester hydrolysis was obtained from rat kidney tubules. A molecular weight of about 4700 was estimated for this kallikrein-specific inhibitor (trypsin-induced kinin-liberation is not prevented).
D000595:Amino Acid Sequence; D006801:Humans; D007249:Inflammation / Q000201:enzymology; D007610:Kallikreins / Q000037:antagonists & inhibitors*; D007684:Kidney Tubules / Q000502:physiology; D008958:Models, Molecular; D008970:Molecular Weight; D009504:Neutrophils / Q000201:enzymology*; D011480:Protease Inhibitors
D011480:Protease Inhibitors; D007610:Kallikreins