Selective inactivation of catalase during protoporphyrin induced photohemolysis of human red blood cells.
The level of some enzymatic activities in red blood cells before and after photohemolysis induced by protoporphyrin IX was studied. A 30% decrease in catalase activity was found both in normal erythrocytes and those from patients affected by favism. Other proteins though present in larger amounts inside the erythrocytes are not affected by the photohemolytic process.
D002374:Catalase / Q000097:blood / Q000528:radiation effects*; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology / Q000528:radiation effects*; D005236:Favism / Q000097:blood / Q000201:enzymology; D006461:Hemolysis / Q000187:drug effects / Q000528:radiation effects*; D006801:Humans; D008027:Light; D011166:Porphyrins / Q000494:pharmacology*; D011524:Protoporphyrins / Q000494:pharmacology*
D011166:Porphyrins; D011524:Protoporphyrins; D002374:Catalase