Epidermal activity in the involved and uninvolved skin of patients with psoriasis.
A simple biochemical technique has been used to study the rate of incorporation of precursor materials in the involved and uninvolved skin of psoriatic subjects. Psoriatic plaques were found to incorporate tritaited thymidine twice as rapidly as skin from control subjects. The uninvolved skin of psoriatics showed a 48% increase in thymidine incorporation. Histidine and proline incorporations were also increased in psoriatic plaques but not in the uninvolved skin of psoriatics.
D000328:Adult; D000368:Aged; D004247:DNA / Q000096:biosynthesis; D004817:Epidermis / Q000378:metabolism; D005260:Female; D006639:Histidine / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D011392:Proline / Q000378:metabolism; D011565:Psoriasis / Q000378:metabolism*; D012867:Skin / Q000378:metabolism*; D013936:Thymidine / Q000378:metabolism
D006639:Histidine; D004247:DNA; D011392:Proline; D013936:Thymidine