The effect of vincamine on the regional cerebral blood flow in man.
The cerebral hemodynamic action of Vincamine is measured in 17 patients with primary or secondary cerebral circulation disorders, by use of the multiregional 133Xe clearance technique. The statistical analysis of the results justifies the grouping of all the cases and the distinction between reference, ischemic and hyperemic zones by determining for each subject a range of + or - 15% of his own mean regional cerebral blood flow. The drug, in a single injection in the internal carotid artery, shows a significant beneficial hemodynamic effect on the ischemic regions of the brain. No steal phenomenon is recorded in the middle cerebral artery territory. The action of the drug leads to a decrease  and an equalization of the hemodynamic resistances of the cerebral vascular bed.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D006849:Hydrocephalus / Q000188:drug therapy / Q000503:physiopathology; D002542:Intracranial Embolism and Thrombosis / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D014748:Vinca Alkaloids / Q000494:pharmacology* / Q000627:therapeutic use; D014980:Xenon Radioisotopes
D014748:Vinca Alkaloids; D014980:Xenon Radioisotopes