[Impairment of adrenergic innervation in achalasia (author's transl)].
Length tension diagrams and diagrams of isometrically developed active tension were set up for normal and aganglionic cardia-circular muscles. The effects of acetylcholin, adrenergic stimulating and inhibiting drugs were examined. The physiological parameters in healthy cardia and the cardia muscle system in achalasia did not vary significantly from one another. The acetylcholin threshold was higher in aganglionic cardia, while the maximum effective dose in healthy and aganglionic cardia remained the same. In achalasia no sensitisation to acetylcholine was detectable. There was a marked impairment in the balance between adrenergic alpha- and beta-receptors, with the contraction-inducing alpha-receptors obviously predominating.
D000109:Acetylcholine / Q000494:pharmacology; D002217:Carbachol / Q000494:pharmacology; D002299:Cardia / Q000294:innervation*; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000494:pharmacology; D004931:Esophageal Achalasia / Q000503:physiopathology*; D006801:Humans; D009119:Muscle Contraction / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology
D002217:Carbachol; D000109:Acetylcholine; D009638:Norepinephrine; D004837:Epinephrine
Störung der adrenergen Innervation bei Achalasie.