Subclasses IgG1--IgG4 in 84 sera with IgG paraprotein.
The distribution of subclasses IgG1-4 was determined in 84 sera with IgG paraprotein. The results were as follows: IgG1--58.3%, IgG2--25%, IgG3--11.9%, IgG4--4.8%. After division into the group of IgG myelomas (n = 47) and the group of non-myeloma IgG paraproteinemias (n = 37), the following distribution was found: IgG1--55.3%, IgG2--25.5%, IgG3--12.7%, IgG4--6.5% and IgG1--62.1%, IgG2--24.3%, IgG3--10.8%, IgG4--2.7%, respectively. The distribution of light chains in the individual subclasses of IgG paraproteins was also studied. In three double IgG and IgA myeloma paraproteinemias, subclass 1 IgG paraprotein was always demonstrated.
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007070:Immunoglobulin A; D007074:Immunoglobulin G / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood / Q000276:immunology; D009194:Myeloma Proteins / Q000032:analysis; D010265:Paraproteinemias / Q000097:blood / Q000276:immunology; D010266:Paraproteins / Q000032:analysis*
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D009194:Myeloma Proteins; D010266:Paraproteins