Attenuation of amnesia in rats by systemically administered enkephalins.
The pentapeptides methionine-enkephalin and leucine-enkephalin are both able to reduce experimentally induced amnesia in rats. In contrast to the possible analgesic activity of these peptides, the anti-amnesic effect is seen after systemic administration of dosages of 30 micrograms or lower. The nature of the anti-amnesic effect is different for the two peptides.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D002245:Carbon Dioxide / Q000037:antagonists & inhibitors; D004305:Dose-Response Relationship, Drug; D004723:Endorphins / Q000494:pharmacology*; D004745:Enkephalins / Q000494:pharmacology*; D008297:Male; D008568:Memory / Q000187:drug effects*; D051381:Rats; D013997:Time Factors
D004723:Endorphins; D004745:Enkephalins; D002245:Carbon Dioxide