[Long-term treatment of arterial hypertension with propranolol. Combination with diuretics and dihydrazinophthalazine].
The effect of long-term treatment of hypertension with propranolol, alone or in combination with hydrochlorothiazide and/or dihydralazine, was investigated in 93 patients with various types of hypertension. Normalisation of the B. P. was obtained within two-four weeks of treatment with propranolol alone in all cases with mild hypertension, and in 77% and 44% of moderate and severe forms respectively. These percentages were even higher when propranolol was employed with hydrochlorothiazide and/or dihydralazine. The rationale of this combination and the mechanism of the hypotensive effect of propranolol are discussed. The drug was well tolerated; major side effects did not occur.
D000328:Adult; D004078:Dihydralazine / Q000627:therapeutic use*; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006830:Hydralazine / Q000031:analogs & derivatives*; D006852:Hydrochlorothiazide / Q000627:therapeutic use*; D006973:Hypertension / Q000188:drug therapy*; D006977:Hypertension, Renal / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D011433:Propranolol / Q000627:therapeutic use*; D013997:Time Factors
D006852:Hydrochlorothiazide; D006830:Hydralazine; D011433:Propranolol; D004078:Dihydralazine
Trattamento cronico dell'ipertensione arteriosa con propranololo. Associazione con diuretici e diidrazinoftalazina.