The effects of exercise on the amplitude of the first heart sound in normal subjects.
The cardiovascular responses to isometric and dynamic exercise have been studied in six normal subjects, before and after intravenous propranolol, using the amplitude of the first heart sound (S1), measured from an ultra-low frequency phonocardiogram, as an index of left ventricular mechanical performance. Dynamic exercise caused significant increases in heart rate and S1 amplitude which were largely inhibited by beta-adrenergic blockade. Isometric exercise also produced increases in heart rate and blood pressure, but a decrease in S1 amplitude. Propranolol had no significant effect on the cardiovascular response to isometric exercise. These results confirm previous suggestions that, in contrast to dynamic exercise, the normal cardiovascular responses to isometric exercise are relatively independent of the beta-adrenergic nervous system. Possible reasons why the improvement in left ventricular performance, which has previously been shown to occur during isometric handgrip, was not reflected in the phonocardiogram, are also discussed.
D000328:Adult; D003864:Depression, Chemical; D006326:Heart Auscultation; D006339:Heart Rate; D006347:Heart Sounds; D006439:Hemodynamics; D006801:Humans; D007537:Isometric Contraction; D008297:Male; D005082:Physical Exertion; D011433:Propranolol / Q000494:pharmacology
D011433:Propranolol