Evaluation of drugs in ointment for mydriasis and cycloplegia.
Ointment preparations of cyclopentolate hydrochloride and tropicamide were compared with aqueous drops of these medications for the production of mydriasis and/or cycloplegia in clinic patients. Mydriasis and/or cycloplegia could be accomplished by the single application of a minute volume (around 0.005 ml) of ointment containing these drugs. With the use of ointment preparation, ocular irritation was minimal, and there was no interference with subsequent ocular examination. A delivery system was devised with a piece of silicone-rubber tubing that was filled with an ointment preparation. By squeezing the tubing, a minute volume (about 0.005 ml) of ointment preparation was expressed.
D000065:Accommodation, Ocular / Q000187:drug effects*; D002924:Ciliary Body / Q000187:drug effects*; D003519:Cyclopentolate / Q000008:administration & dosage / Q000494:pharmacology*; D004341:Drug Evaluation; D006801:Humans; D009184:Mydriatics / Q000008:administration & dosage* / Q000494:pharmacology; D009824:Ointments; D010648:Phenylacetates / Q000494:pharmacology*; D010656:Phenylephrine / Q000008:administration & dosage / Q000494:pharmacology; D011680:Pupil / Q000187:drug effects*; D011725:Pyridines / Q000008:administration & dosage* / Q000494:pharmacology
D009184:Mydriatics; D009824:Ointments; D010648:Phenylacetates; D011725:Pyridines; D010656:Phenylephrine; D003519:Cyclopentolate