Inhibition of the ligase step of excision repair by 2-chloroethyl isocyanate, a decomposition product of 1,3-bis(2-chloroethyl)-1-nitrosourea.
D001973:Bromodeoxyuridine / Q000378:metabolism; D002330:Carmustine / Q000378:metabolism; D002460:Cell Line; D003485:Cyanates / Q000494:pharmacology*; D011088:DNA Ligases / Q000378:metabolism*; D004260:DNA Repair / Q000187:drug effects* / Q000528:radiation effects; D004277:DNA, Single-Stranded / Q000378:metabolism; D005018:Ethyl Chloride / Q000031:analogs & derivatives / Q000494:pharmacology; D017953:Isocyanates; D011118:Polynucleotide Ligases / Q000378:metabolism*; D014466:Ultraviolet Rays
D003485:Cyanates; D004277:DNA, Single-Stranded; D017953:Isocyanates; C006995:2-chloroethyl isocyanate; D005018:Ethyl Chloride; D011088:DNA Ligases; D011118:Polynucleotide Ligases; D001973:Bromodeoxyuridine; D002330:Carmustine