Diatrizoate enemas: facts and fallacies of colonic toxicity.
Rats were given enemas of Gastrografin in two strengths, Renografin--76, and Tween--80 in a 10% dilution. There were no deleterious effects on the colons with these media used in volumes to fill the colon. Severe changes resulted from volumes which produced overdistention.
D000818:Animals; D003106:Colon / Q000187:drug effects*; D003287:Contrast Media / Q000008:administration & dosage / Q000633:toxicity*; D003973:Diatrizoate / Q000031:analogs & derivatives*; D003974:Diatrizoate Meglumine / Q000008:administration & dosage / Q000633:toxicity*; D004733:Enema / Q000009:adverse effects*; D051381:Rats
D003287:Contrast Media; D003973:Diatrizoate; D003974:Diatrizoate Meglumine