Fascicular nerve allograft evaluation. Part 2: comparison with whole-nerve allograft by light microscopy.
Orthotopic whole-nerve and fascicular nerve grafts were transplanted between inbred rats with known histocompatibility antigen structure. In general, the whole sciatic nerves demonstrated a graded rejection response dependent upon the degree of tissue histocompatibility differences. The fascicular grafts, however, had evidence of greatly decreased rejection and no stigma of a graded response dependent on degree of variability of tissue typing. Limitations of the experiment are outlined, and the possible avenues of further research are briefly discussed.
D000818:Animals; D006084:Graft Rejection; D051381:Rats; D011919:Rats, Inbred Strains; D012584:Sciatic Nerve / Q000033:anatomy & histology / Q000637:transplantation*; D014184:Transplantation, Homologous