[Effect of O,N'=dichlorodiphenyldichloroethane and pertan in vitro on glutathione reductase activity in the adrenals of dogs and guinea pigs].
Glutathione reductase is activated by o,p'-dichlorodiphenyldichlorethane (o,p'-DDD) and pertan added in a concentration of 312 micrometer to the homogenate and cytoplasmic fraction of the dog adrenals. At a concentration of 156 micrometer o,p'-DDD and pertan failed to influence the glutathione reductase activity of the dog adrenal glands. Added in vitro, o,p'-DDD and pertan activate glutatione reductase of the quinea pig adrenal glands. O,p'-DDD does not affect the glutathione reductase activity of the liver and kidney cytoplasmic fraction in dogs. This observation confirms the high specificity of o,p'-DDD action on the adrenal glands.
D000311:Adrenal Glands / Q000187:drug effects* / Q000201:enzymology; D000818:Animals; D004285:Dogs; D004789:Enzyme Activation; D005980:Glutathione Reductase / Q000378:metabolism*; D006168:Guinea Pigs; D008939:Mitotane / Q000031:analogs & derivatives* / Q000494:pharmacology*; D013045:Species Specificity
D008939:Mitotane; D005980:Glutathione Reductase
Vliianie O,N'=dikhlordifenildikhloretana i pertana in vitro na aktivnost' glutationreduktazy v nadpochechnikakh sobak i morskikh svinok.