[Liver tumors induced in mice by prenatal and postnatal administration of ortho-aminoazotoluene].
The authors studied the prenatal and postnatal blastomogenic action of orthoaminoazotoluol (OAAT) on the liver of CBA mice. OAAT was administered to mice intragastrically in oil solution, thrice, 4 mg each time (a total of 12 mg). Twelve months after the OAAT administration tumours of the liver during the postnatal period were revealed in 89.3% of female mice (11.5% in control), and in 78.7% of male mice (68.5% in control). In the experimental progeny subjected to OAA action during last 4--5 days of the prenatal period the liver tumours appeared in females at the age of 12 months in 54.8% of cases (5.3% in control), and in males--in 81.1% (35.2% in control). In this progeny, particularly in the male animals malignant neoplasms occurred more frequently than in the intact animals and those subjected to the action of OAAT during the postnatal period.
D000818:Animals; D001391:Azo Compounds / Q000633:toxicity*; D005260:Female; D008113:Liver Neoplasms / Q000139:chemically induced*; D008297:Male; D008431:Maternal-Fetal Exchange; D051379:Mice; D008808:Mice, Inbred CBA; D009374:Neoplasms, Experimental / Q000139:chemically induced; D011247:Pregnancy; D012737:Sex Factors; D009762:o-Aminoazotoluene / Q000633:toxicity*
D001391:Azo Compounds; D009762:o-Aminoazotoluene
Opukholi pecheni u mysheĭ, vyzvannye prenatal'nym i postnatal'nym vvedeniem ortoaminoazotoluola.