Carcinomas of the liver and forestomach in mice ingesting chlorobenzilate.
The maximal tolerated dose of chlorobenzilate was given by continuous oral administration, starting at the age of 7 days, to both sexes of two hybrid strains of mice-(C57BL/6 X C3HAnf)F1 and (C57BL/6 X AKR)F1. There was an increased incidence of tumors in one or more organs in male mice of both strains and female mice of the (C57BL/6 X C3HAnf)F1 strain. Male mice of both strains developed significantly elevated incidences of carcinomas of the liver. Female (C57BL/6 X C3HAnf)F1 strain mice had a significantly increased incidence of hyperplasia and carcinomas of the forestomach.
D000818:Animals; D001561:Benzilates / Q000633:toxicity*; D005260:Female; D006965:Hyperplasia; D007306:Insecticides / Q000633:toxicity*; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000139:chemically induced*; D008175:Lung Neoplasms / Q000139:chemically induced; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009362:Neoplasm Metastasis; D009374:Neoplasms, Experimental / Q000139:chemically induced; D013270:Stomach / Q000473:pathology; D013274:Stomach Neoplasms / Q000139:chemically induced*
D001561:Benzilates; D007306:Insecticides