[Change in the density of surface lymphocyte receptors and in the level of serum immunoglobulins in chronic lympholeukosis].
Using the complex of methods for recognition of surface lymphocyte receptors the authors examined 42 patients with chronic lymphatic leukemia and 30 healthy individuals. The reduced density of receptors on lymphocyte surface or their total absence is characteristic of the whole group of patients with chronic lymphatic leukemia. This atypism of leukemia lymphocytes is augmented in greater rate of neoplastic cells growth. Total synthesis of serum immunoglobulins in chronic lymphatic leukemia is found to be lowered, the fall being more sharp in increased amount of lymphocytes in peripheral blood.
D000328:Adult; D001666:Binding Sites, Antibody; D002462:Cell Membrane / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D007074:Immunoglobulin G / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis*; D007945:Leukemia, Lymphoid / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology*; D008875:Middle Aged; D012397:Rosette Formation
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M
Izmenenie plotnosti retseptorov na poverkhnosti limfotsitov i urovnia syvorotochnykh immunoglobulinov pri khronicheskom limfoleĭkoze.