Fluorescence microscopical study of 5-hydroxytryptamine storage organelles in mepacrine-incubated blood platelets of beige mice (Chediak-Higashi syndrome).
The number and fluorescence intensity of fluorescent granules (5-HT storage organelles) of mepacrine-incubated blood platelets of beige mice (Chediak-Higashi syndrome) are decreased compared to those of control mice platelets. This indicates both quantitative and qualitative changes of the 5-HT organelles, namely a reduced number and a reduced storage capacity, respectively.
D000818:Animals; D001792:Blood Platelets / Q000378:metabolism*; D002609:Chediak-Higashi Syndrome / Q000097:blood*; D006651:Histocytochemistry; D051379:Mice; D008856:Microscopy, Fluorescence; D011796:Quinacrine / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism*
D012701:Serotonin; D011796:Quinacrine