title: Red blood cell size and glycolytic enzyme activity: relationship to number of intramedullary cell divisions.
abstract: In order to assess how the number of cell divisions influences the red blood cell (RBC) content of proteins other than hemoglobin, we measured the activity of two age-independent glycolytic enzymes in macrocytic, normal, and microcytic RBCs. The enzymes measured were phosphoglycerate kinase (PGK) and lactic dehydrogenase (LDH). In macrocytes, both PGK and LDH activity/10(10) RBCs were increased 1.6-fold over normal RBCs. In microcytes, however, the activity of these enzymes was identical to that seen in normal RBCs.
mesh_terms: D002455:Cell Division; D004912:Erythrocytes / Q000166:cytology* / Q000201:enzymology; D005954:Glucosephosphate Dehydrogenase / Q000097:blood; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D066298:In Vitro Techniques; D007770:L-Lactate Dehydrogenase / Q000097:blood; D010735:Phosphoglycerate Kinase / Q000097:blood
chemical_list: D006454:Hemoglobins; D007770:L-Lactate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D010735:Phosphoglycerate Kinase