title: Micro and macro GLC determination of ethambutol in biological fluids.
abstract: Previously available GLC methods for ethambutol may only be used to measure quantities of drugs much greater than those found in biological fluids such as plasma and dialysate. A previously published GLC method for plasma samples is extended to measure ethambutol in dialysate. A second GLC method, involving derivatization with bis(trimethylsilyl)trifluoroacetamide and subsequent quantitation using a flame-ionization detector, is described for urine samples. With a dual-column and dual-detector gas--liquid chromatograph, simultaneous micro (plasma and dialysate) and macro (urine) determinations of ethambutol are possible.
mesh_terms: D000328:Adult; D002849:Chromatography, Gas / Q000379:methods; D004977:Ethambutol / Q000032:analysis*; D006801:Humans; D013058:Mass Spectrometry; D008832:Microchemistry; D006435:Renal Dialysis
chemical_list: D004977:Ethambutol