The effect of halothane on the distribution of cardiac output and organ blood flows in the hemorrhagic, hypotensive dog.
Halothane was given to dogs which had been bled to an arterial mean blood pressure of 60 mmHg, and the circulatory effects were studied with the aid of the radioactive microsphere technique. The cardiac output and coronary blood flow were well maintained, whereas the arterial mean blood pressure was slightly, and the stroke volume markedly increased, indicating an improved heart function. The blood flows to the brain, lungs, liver and kidneys were well preserved throughout the anesthesia. The effect of retransfusing the withdrawn blood was also studied, and it resulted in an increased cardiac output, arterial mean blood pressure and increased blood flows to the heart, lungs, spleen, bowel and liver.
D000758:Anesthesia; D000818:Animals; D001803:Blood Transfusion; D002302:Cardiac Output / Q000187:drug effects*; D004285:Dogs; D006221:Halothane / Q000494:pharmacology*; D007022:Hypotension / Q000503:physiopathology*; D012039:Regional Blood Flow / Q000187:drug effects*; D012771:Shock, Hemorrhagic / Q000503:physiopathology*; D014655:Vascular Resistance / Q000187:drug effects
D006221:Halothane