Intercellular adhesiveness of H-2 identical and H-2 disparate cells.
Using a 2 X 2 design, the collection rates of cells from radioactively labelled single-cell suspensions on cell-coated collecting surfaces were tested for a possible H-2 effect on intracellular adhesiveness. By a statistical procedure, the undesirable variability in the suspension and/or in the collecting surface could be eliminated, and the H-2 specific net effect estimated. In this way it was possible to detect (even on the background of a large non-specific variability) significant reductions of the allogeneic collection rates (i.e. between cells which differed only in their H-2 haplotypes) as compared to the syngeneic standards. It is concluded that cells of a given H-2 haplotype have preferential adhesiveness to syngeneic cells.
D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology / Q000276:immunology; D001853:Bone Marrow / Q000276:immunology; D001854:Bone Marrow Cells; D002448:Cell Adhesion; D002478:Cells, Cultured; D006183:H-2 Antigens; D051379:Mice; D008810:Mice, Inbred C57BL; D010641:Phenotype
D006183:H-2 Antigens