Failure of heterotopic osteogenesis by epithelial mesenchymal cell interactions in xenogeneic transplants in the kidney.
Transitional epithelium of the guinea pig and rabbit and an established WISH cell line, when grafted under the kidney capsule of cortisone treated mice, survived and proliferated, but never induced bone formation. On the contrary, when grafted intramuscularly into the same recipients, readily induced cartilage and/or bone.
D000818:Animals; D002460:Cell Line; D004848:Epithelium / Q000637:transplantation*; D006168:Guinea Pigs; D006801:Humans; D007668:Kidney / Q000601:surgery*; D051379:Mice; D009132:Muscles / Q000601:surgery; D010012:Osteogenesis; D011817:Rabbits; D014183:Transplantation, Heterologous; D001743:Urinary Bladder