[Effect adrenaline and ephedrine against a background of aminazine on systemic, cerebral and extracerebral hemodynamics].
Experiments with anesthetized cats demonstrated chlorpromazine (2 mg/kg) to pervert the vasopressor action of adrenaline (5 mkg/kg) and ephedrine (2 mg/kg) on the systemic arterial pressure, cerebral and extracerebral tonicity of the vessels. The authors believe that with chlorpromazine pretreatment the adrenomimetics produce a selective stimulation of the beta-adrenergic receptors, this accounting for the observed depressor effect.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D002746:Chlorpromazine / Q000494:pharmacology*; D004347:Drug Interactions; D004809:Ephedrine / Q000494:pharmacology*; D004837:Epinephrine / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects*; D013997:Time Factors; D014662:Vasoconstrictor Agents
D014662:Vasoconstrictor Agents; D004809:Ephedrine; D002746:Chlorpromazine; D004837:Epinephrine
Vliianie adrenaline i éfedrina na fone aminazina na obshchuiu, tserebral'nuiu i ékstratserebral'nuiu gemodinamiku.