Mononuclear leucocyte chemotaxis in Boyden chambers: inhibition by subantimitotic concentrations of antitubulins.
The chemotaxis of Lymphoprep -isolated human mononuclear leucocytes (L-MNs) from peripheral blood was inhibited by subantimitotic concentrations of the antitubulins demecolcine, podophyllic acid ethylhydrazide, vinblastine and griseofulvin. It is suggest that L-MN chemotaxis, like polymorphonuclear leucocyte (PMN) chemotaxis, is composed of a direct antitubulin-insensitive chemotaxis and a leukocyte-induced antitubulin-sensitive chemotaxis.
D000970:Antineoplastic Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D003703:Demecolcine / Q000494:pharmacology; D006801:Humans; D007958:Leukocyte Count; D008722:Methods; D008938:Mitosis / Q000187:drug effects; D009000:Monocytes / Q000276:immunology*; D011033:Podophyllin / Q000494:pharmacology; D011763:Pyrrolizidine Alkaloids / Q000031:analogs & derivatives / Q000494:pharmacology; D014747:Vinblastine / Q000494:pharmacology
D000970:Antineoplastic Agents; D011763:Pyrrolizidine Alkaloids; D014747:Vinblastine; D011033:Podophyllin; D003703:Demecolcine