Comparison of plasma and saliva levels of metoprolol and oxprenolol.
1 Plasma and saliva levels of metoprolol and oxprenolol have been compared in two groups of healthy volunteers. 2 Mean salivary oxprenolol levels were lower than, but closely related to the corresponding plasma levels (r=0.93), the mean ratio of saliva:plasma concentration being 0.42. 3 Mean salivary metoprolol concentrations were considerably greater thatn the corresponding plasma levels and the relationship between the concentrations in the two fluids was less clear. 4 The evidence presented suggests that oxprenolol diffuses passively whilst metoprolol is actively secreted into saliva. The mechanism involved in the active process is not known.
D000293:Adolescent; D000328:Adult; D000681:Amylases / Q000378:metabolism; D006801:Humans; D008297:Male; D008790:Metoprolol / Q000097:blood / Q000378:metabolism*; D010096:Oxprenolol / Q000097:blood / Q000378:metabolism*; D011412:Propanolamines / Q000378:metabolism*; D012463:Saliva / Q000378:metabolism*; D012471:Salivary Proteins and Peptides / Q000378:metabolism; D012472:Salivation / Q000187:drug effects; D013997:Time Factors
D011412:Propanolamines; D012471:Salivary Proteins and Peptides; D010096:Oxprenolol; D000681:Amylases; D008790:Metoprolol