[Effect of deoxycytidine on the frequency of sister chromatid exchanges in human lymphocytes detected by using 5-bromdeoxyuridine].
The frequency of sister chromatid exchanges (SCE) was studied in cultivated blood lymphocytes of three normal individuals under elimination of DNA synthesis inhibiting action of 5-bromodeoxyuridine (BrdUrd 0.05 mM) with deoxycytidine (Cdr 0.1 and 0.01 mM). The frequency of SCE was significantly increased in the presence of 0.1 mM Cdr. In parallel with SCE frequency, Cdr elevated the percentage of metaphases of the second division. The increase of SCE in the presence of Cdr may be connected with normalization of the DNA replication under its action.
D001973:Bromodeoxyuridine / Q000494:pharmacology; D002478:Cells, Cultured; D002842:Chromatids / Q000187:drug effects*; D003434:Crossing Over, Genetic / Q000187:drug effects*; D003841:Deoxycytidine / Q000494:pharmacology*; D006801:Humans; D008214:Lymphocytes
D003841:Deoxycytidine; D001973:Bromodeoxyuridine
Vliianie dezoksitsitidina na chastotu sestrinskikh khromatidnykh obmenov v limfotsitakh cheloveka, vyiavliaemykh s pomoshch'iu 5-bromdeoksiuridina.