title: [Pharmacokinetics of ampicillin in acute appendicitis in children].
abstract: The pharmocokynetics of a semisynthetic penicillin-ampicillin in acute appendicitis in children has been studied. Intramuscular and intravenous injections of 12,5 mg/kg and 25 mg/kg single doses of the antibiotic were administered. 50 children aged from 4 to 14 years were examined. Both ways of administration led to the creation of the ampicillin therapeutic concentration in the blood serum, but in case of intramuscular injection the circulation of the antibiotic in the blood was more prolonged. With the increase of the dose the antibiotic concentration in the blood and tissues of the abdominal cavity rises but without any significant prolongation of its circulation time in the blood.
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000667:Ampicillin / Q000008:administration & dosage / Q000378:metabolism* / Q000627:therapeutic use; D001064:Appendicitis / Q000188:drug therapy*; D001065:Appendix / Q000378:metabolism; D001682:Biological Availability; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007273:Injections, Intramuscular; D007275:Injections, Intravenous
chemical_list: D000667:Ampicillin
vernacular_title: Farmakokinetika ampitsillina pri ostrom appenditsite u deteĭ.