title: Studies on the nature of the peripheral sudomotor control mechanism.
abstract: Electron microscopical studies of the sweat glands of the body surface of the cow, sheep, goat and cat demonstrated that there were few nerves or blood vessels near the glands. No varicosities were found within 10 micron of the glands, and the small number of unmyelinated nerve bundles traced were over 1.5 micron from the glandular myoepithelium, and situated outside a fibrocyte sheath surrounding the glands. It was concluded that the sweat glands of these species are not innervated. Unmyelinated nerve fibres were more abundant around, and were closer to, the sweat glands of man, the horse and cat footpads, and varicosities were observed within the fibrocyte sheath close enough to have a direct influence on the glands. It is postulated from the comparative evidence that the basic sudomotor mechanism is the same in all species, involving the action of adrenergic and cholinergic nerves on the cutaneous blood vessels and local catecholamine transfer to the gland; and that in species such as man where the blood supply and sympathetic nerves are in close proximity to the glands, transmitters released at the sympathetic nerve endings, in particular acetylcholine, will, in addition, have a direct action on the glands.
mesh_terms: D000328:Adult; D000818:Animals; D002415:Cats; D002417:Cattle; D005260:Female; D006041:Goats; D006736:Horses; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D009474:Neurons / Q000648:ultrastructure; D012756:Sheep; D013545:Sweat Glands / Q000098:blood supply / Q000294:innervation* / Q000648:ultrastructure