[Effect of neuroleptics on acetylcholine metabolism in the basal ganglia of the brain].
Neuroleptics (haloperidol) closapine, pimozid, chlorpromazine) diminished the level of free (functionally active) form of acetylcholine (ACh), and, to some extent, the bound form of ACh; they changed the content of the labile-bound (vesicular) form of ACh and weakly influenced the choline-acetyltranspherase activity in the basal ganglia of the rat brain 5 to 30 min after the injection. In contrast to the inhibitory action on the acetyl-cholinesterase (AChE) activity in vitro, most of the neuroleptics, except closapine, increased the AChE activity in vivo. These results indicate that the neuroleptics activate ACh-metabolism and probably stimulate the cholinergic structure in the basal ganglia of the brain; the AChE activity may serve as a criterion of such stimulating action of neuroleptics.
D000109:Acetylcholine / Q000378:metabolism*; D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D001479:Basal Ganglia / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D002746:Chlorpromazine / Q000494:pharmacology; D003024:Clozapine / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D010868:Pimozide / Q000494:pharmacology; D051381:Rats; D014149:Tranquilizing Agents / Q000494:pharmacology*
D014149:Tranquilizing Agents; D010868:Pimozide; D000110:Acetylcholinesterase; D003024:Clozapine; D006220:Haloperidol; D000109:Acetylcholine; D002746:Chlorpromazine
Vliianie neĭroleptikov na obmen atsetilkholina v bazal'nykh gangliiakh mozga.