title: Q fever endocarditis: a report of 2 cases.
abstract: Two patients with Q fever endocarditis are described. Both patients demonstrated some of the characteristic features of Q fever endocarditis, i.e. the long course of the disease before diagnosis, persistently negative blood cultures, resistance to conventional antibiotic therapy and a dramatic response to tetracycline therapy. Complications included arteriovenous thrombo-embolism and hepatic enlargement, and 1 patient developed an immune complex form of glomerulonephritis. The possibility of Q fever endocarditis should be considered in all patients with infective endocarditis in whom blood cultures are negative and who fail to respond to conventional antibiotic therapy.
mesh_terms: D000328:Adult; D004697:Endocarditis, Bacterial / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D005921:Glomerulonephritis / Q000209:etiology; D006801:Humans; D008107:Liver Diseases / Q000209:etiology; D008297:Male; D011778:Q Fever / Q000150:complications* / Q000188:drug therapy; D013752:Tetracycline / Q000627:therapeutic use
chemical_list: D013752:Tetracycline