Increased solubility of collagen. A biochemical defect in the experimental hydralizine-induced collagen disease-like syndrome.
An increase of soluble fractions of collagen and a decrease of insoluble ones was found in the skin of guinea pigs with collagen disease-like syndrome, produced by prolonged treatment with hydralazine. Chromatography studies showed that the collagen alpha chains content in the skin increased and beta-chains decreased under conditions of the development of lupus-like syndrome. The obtained results suggested the inhibition of collagen maturation as one of biochemical defects of connective tissue in drug-induced collagen disease-like syndrome.
D000818:Animals; D002845:Chromatography / Q000379:methods; D003094:Collagen / Q000378:metabolism*; D003095:Collagen Diseases / Q000139:chemically induced / Q000378:metabolism*; D006830:Hydralazine; D012995:Solubility; D013552:Swine; D013577:Syndrome
D006830:Hydralazine; D003094:Collagen