title: Biochemistry of metallocenes. Identification of the major metabolite of acetylruthenocene.
abstract: 1. After oral administration of acetylruthenocene to rats, metabolites were detected in bile and urine. 2. The major metabolite, which is present in both bile and urine, is a glucuronide with the structure: C5H5-Ru-C5H4-CO-CH2-O-C6H9O6 3. The metabolite was identified by mass spectrometry of the permethylated glucuronide and mass spectrometry and n.m.r. of the aglycone. 4. The nature of the metabolite is discussed, and a comparison is made with the metabolism of the benzene analogue, acetophenone.
mesh_terms: D000818:Animals; D001646:Bile / Q000032:analysis; D005260:Female; D005965:Glucuronates / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000378:metabolism* / Q000652:urine; D051381:Rats; D012428:Ruthenium
chemical_list: D005965:Glucuronates; D009942:Organometallic Compounds; C013108:metallocene; C016199:acetylruthenocene; D012428:Ruthenium