Chemotherapeutic response in metastatic medulloblastoma: report of two cases and a review of the literature.
Metastatic medulloblastoma is a rare clinical phenomenon. Review of the literature and the authors' experience reveals that when it occurs, palliation may be achieved with a variety of single and combination chemotherapy programs. Two objective responses with vincristine-actinomycin-D-cyclophosphamide (VAC) and one each with adriamycin and methyl-CCNU are described.
D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000188:drug therapy*; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000601:surgery; D003520:Cyclophosphamide / Q000627:therapeutic use; D003609:Dactinomycin / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis / Q000188:drug therapy; D008527:Medulloblastoma / Q000188:drug therapy* / Q000601:surgery; D009362:Neoplasm Metastasis / Q000188:drug therapy*; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy; D011879:Radiotherapy Dosage; D012673:Semustine / Q000627:therapeutic use; D014750:Vincristine / Q000627:therapeutic use
D012673:Semustine; D003609:Dactinomycin; D014750:Vincristine; D003520:Cyclophosphamide