Control of glucose metabolism in isolated acini of the lactating mamary gland of the rat. Effects of oleate on glucose utilization and lipogenesis.
Oleate (1mM) had only small inhibitory effects on glucose utilization and lipogenesis in acini isolated from rat mammary gland. Esterification of [1-14C]oleate was unaffected by insulin but were decreased by 60% by acetoacetate (2mM). Glycerol (1mM), but not insulin, relieved this inhibition. These experiments provide further support for the role of acetoacetate in regulating substrate utilization by the gland.
D000090:Acetoacetates / Q000494:pharmacology; D000818:Animals; D005260:Female; D005947:Glucose / Q000378:metabolism*; D005990:Glycerol / Q000494:pharmacology; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology; D007774:Lactation; D008055:Lipids / Q000096:biosynthesis*; D008321:Mammary Glands, Animal / Q000187:drug effects / Q000378:metabolism*; D009829:Oleic Acids / Q000494:pharmacology*; D011247:Pregnancy; D051381:Rats
D000090:Acetoacetates; D007328:Insulin; D008055:Lipids; D009829:Oleic Acids; D005947:Glucose; D005990:Glycerol