Disulfiram enhances pharmacological activity of barbital and impairs its urinary elimination.
Disulfiram or diethyldithiocarbamate significantly enhanced the sleeping time induced by barbital in rats. At identical time intervals after rats were injected with barbital the concentration of barbital in the blood or brain of animals that had previously received disulfiram was significantly higher than the concentrations in the corresponding tissues of control animals. Urinary excretion of barbital was significantly reduced in disulfiram-treated animals.
D000818:Animals; D001462:Barbital / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology / Q000652:urine; D001463:Barbiturates / Q000378:metabolism*; D001711:Biotransformation / Q000187:drug effects; D001921:Brain / Q000378:metabolism; D004221:Disulfiram / Q000494:pharmacology*; D008297:Male; D051381:Rats; D012890:Sleep / Q000187:drug effects; D014018:Tissue Distribution
D001463:Barbiturates; D001462:Barbital; D004221:Disulfiram