Alteration of haem synthesis in cirrhosis of the liver.
In 51 cases of liver cirrhosis an increased amount of free protoporphyrins in matured erythrocytes was obvious in 22 cases (43%). In 29 cases (57) the amount of EPP rranged at the normal rate. No relationship was found neither to the blood level of bilirubin, iron, protein or of GOT and GPT nor to different histologic findings in liver biopsy slices. The only relation seemed to be as to the amount of fat deposits in hepatocytes. Cases with a high amount of fat had an increased amount of EPP too. Two groups of liver cirrhosis have been separated: one group with EPP amounts above 27/10(11) and another group with EPP amounts below 27/10(11) e., thus ranging within normal rates. Therefore a partial impairment of function is supposed to be and discussed in regard to steroid metabolism.
D004912:Erythrocytes / Q000378:metabolism; D006418:Heme / Q000096:biosynthesis*; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008103:Liver Cirrhosis / Q000378:metabolism*; D011524:Protoporphyrins / Q000096:biosynthesis
D006454:Hemoglobins; D011524:Protoporphyrins; D006418:Heme