[Selective secretion of rat salivary glands after anion administration and the effect of barbiturate on it].
A study was made of the secretion of labeled anions and their metabolites in the salivary composition of 96 adult Wistar rats. Salivary glands were characterized by a high selectivity in the secretion of substances. After the subcutaneous injection of 14C-acetate, 32P-orthophosphate, 35S-thiocyanate, 131I-iodide to control animals in the physiological state 14C concentrated 2.5--6 times more in the mixed saliva than in the blood, but the 32P level was 5 to 20 times less in the saliva than in the blood; 313I and 35S occupied an intermediate position between 14C and 32P. Penetration of labeled anions and their metabolites into the mixed saliva from the blood of rats given barbital Na (medinal) changes significantly: the relative activity of 14C, 35S, 131I saliva/blood was less than in control animals, but the relative activity of 32P saliva/blood proved to be higher in comparison with control rats.
D000085:Acetates / Q000494:pharmacology; D000818:Animals; D000838:Anions; D001462:Barbital / Q000494:pharmacology*; D001463:Barbiturates / Q000494:pharmacology*; D007454:Iodides / Q000494:pharmacology; D010710:Phosphates / Q000494:pharmacology; D051381:Rats; D012469:Salivary Glands / Q000187:drug effects* / Q000378:metabolism; D012472:Salivation; D013861:Thiocyanates / Q000494:pharmacology; D013997:Time Factors
D000085:Acetates; D000838:Anions; D001463:Barbiturates; D007454:Iodides; D010710:Phosphates; D013861:Thiocyanates; D001462:Barbital
Selektivnaia sekretsiia sliunnykh zhelez krys posle vvedeniia anionov i vliianie na nee barbiturata.