Cytostatic activity of organic compounds and their average quasi-valence number.
It is found that the average quasi-valence numbers of alkylating cytostatics lie in the region of potential carcinogens, while the average quasi-valence numbers of antimetabolites predominantly cover the region of noncarcinogens. Implications of this finding on the design of new drugs are discussed.
D000477:Alkylating Agents; D000963:Antimetabolites; D002273:Carcinogens; D008956:Models, Chemical
D000477:Alkylating Agents; D000963:Antimetabolites; D002273:Carcinogens