[Metabolism of glycosaminoglycans and glycoproteids with experimental fractures].
Biochemical studies of the glycosaminoglycanes and glycoproteids metabolism in the callus, liver and blood serum of rabbits with extremty fractures showed that different stages of reparative osteogenesis are accompanied by considerable changes in metabolism of these substances in the callus, fragments adjoining it and the bone tissue of the intact extremty. At the early stages of the knitting consolidation an increase in the level of hyaluronic acid in the callus relatively to the total of glycosaminoglycanes is combined with a rise in the hyaluronidase activity. The rise in the content of carbohydrates bound with proteins: neuraminic acid, hexosamines, hexoses, in the callus, liver and blood serum is also established to be different in different periods of reparative osteogenesis. Comparison of the results of the studies showed a significant role of glycosaminoglycanes and glycoproteids metabolism in the processes knitting consolidation. The data obtained make it possible to specify the role of the bone tissue and liveer as sources of serum glycoproteids under considitions of experimental injury and to recommend the determination of the content of carbohydrate-protein compounds in blood serum as an additional criterion for the course of knitting consolidation.
D000818:Animals; D002146:Bony Callus / Q000378:metabolism; D005260:Female; D005552:Forelimb; D050723:Fractures, Bone / Q000378:metabolism*; D006023:Glycoproteins / Q000097:blood / Q000378:metabolism*; D006025:Glycosaminoglycans / Q000097:blood / Q000378:metabolism*; D006595:Hexosamines / Q000378:metabolism; D006601:Hexoses / Q000378:metabolism; D006820:Hyaluronic Acid / Q000378:metabolism; D006821:Hyaluronoglucosaminidase / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D009438:Neuraminic Acids / Q000378:metabolism; D011817:Rabbits; D014945:Wound Healing
D006023:Glycoproteins; D006025:Glycosaminoglycans; D006595:Hexosamines; D006601:Hexoses; D009438:Neuraminic Acids; D006820:Hyaluronic Acid; D006821:Hyaluronoglucosaminidase
Obmen glikozaminoglikanov i glikoproteidov pri elsperimental'nykh perelomakh.