Thymoindependent antigentic stimulation in nude mice: response to polyvinylpyrrolidone and adjuvant effects of Corynebacterium parvum and LH1.
The humoral thymoindependent response to polyvinylpyrrolidone (PVP) measured by the Farr test, was not different in athymic nude and phenotypically normal mice. In athymic and normal mice, this response was significantly increased by Cornebacterium parvum administered at the time of immunization. A recently synthetized compound, LH1 (3alpha-N-[2 aminoethanol]-amino 5-alpha-pregnane-20-one) was, however, a better immunostimulant of the anti-PVP response in athymic mice.
D000276:Adjuvants, Immunologic; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D005260:Female; D008099:Liver / Q000276:immunology; D008198:Lymph Nodes / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D051379:Mice; D008819:Mice, Nude / Q000276:immunology*; D011205:Povidone / Q000276:immunology*; D011278:Pregnanes / Q000494:pharmacology*; D011425:Propionibacterium acnes / Q000276:immunology
D000276:Adjuvants, Immunologic; D011278:Pregnanes; D011205:Povidone