Fibrosing alveolitis (pulmonary interstitial fibrosis) evoked by experiemntal inhalation of Gasoline vapours.
Rats exposed to an atmosphere contaminated with gasoline vapour for 6--12 weeks exhibit progressive focal interstitial fibrosis of the lung, which is associated with irregular alveolar collapse. It is suggested that this experimental model of diffuse fibrosing lung disease constitutes a useful tool for the study of the dynamics of pulmonary reactivity to atmospheric pollutants and which may facilitate an understanding of the pathogenesis of fibrosing alveolitis in man.
D000393:Air Pollutants / Q000633:toxicity; D000818:Animals; D004195:Disease Models, Animal; D004781:Environmental Exposure; D005742:Gasoline / Q000633:toxicity*; D010578:Petroleum / Q000633:toxicity*; D011658:Pulmonary Fibrosis / Q000139:chemically induced* / Q000473:pathology; D051381:Rats; D013997:Time Factors
D000393:Air Pollutants; D005742:Gasoline; D010578:Petroleum