title: The influence of the type of sulphate bond and degree of sulphation of glycosaminoglycans on their interaction with lysosomal enzymes.
abstract: Significant differences occur between the interaction of several sulphated glycosaminoglycans with a particular lysosomal protein, leading to inhibition in the case of lysosomal enzymes. The order of strength of inhibition at pH4 was: heparin greater than chondroitin 4-sulphate = chondroitin 6-sulphate greater than dermatan sulphate.
mesh_terms: D004791:Enzyme Inhibitors; D006025:Glycosaminoglycans / Q000494:pharmacology*; D008247:Lysosomes / Q000201:enzymology*; D013431:Sulfates
chemical_list: D004791:Enzyme Inhibitors; D006025:Glycosaminoglycans; D013431:Sulfates