title: [Radioimmunoassay [RIA] of cholecystokinin-pancreozymin [33-CCK] (author's transl)].
abstract: A further specific, reproducible radioimmunoassay of cholecystokinin-pancreozymin was developed. 125J-labelled 39-CCK was used as tracer. The limit of detection for CCK in serum was 40 pg/ml. Basal levels for CCK have been found to be 222 pg/ml, being increased after food ingestin. No crossreactivity with gastronintestinal hormones could be observed. Somatostatin was inhibiting the stimulated CCK-release. Histochemical and radioimmunological determinations localized CCK-containing cells in duodenal tissue of humans. Physiological and pathological processes in which CCK is involved have to be studied to evaluate its role in the gastrointestinal tract.
mesh_terms: D002766:Cholecystokinin / Q000097:blood* / Q000502:physiology; D003429:Cross Reactions; D004386:Duodenum / Q000378:metabolism; D005768:Gastrointestinal Hormones / Q000502:physiology; D006651:Histocytochemistry; D006801:Humans; D011863:Radioimmunoassay / Q000379:methods*
chemical_list: D005768:Gastrointestinal Hormones; D002766:Cholecystokinin
vernacular_title: Radioimmunologische Bestimmung (RIA) von Cholezystokinin-Pankreozymin (33-CCK).