title: Pathogenesis of persistent truncus arteriosus in light of observations made in a dog embryo with the anomaly.
abstract: Among 36 embryos obtained from a strain of Keeshond dogs in which there is a large incidence of spontaneously occurring conotruncal anomalies, a specimen with persistent truncus arteriosus, type 1 was found. The embryo had a crown-rump length of 20 mm. The specimen was serially sectioned and a wax plate reconstruction was made of the heart and proximal great vessels at a magnification of X100. The truncal valve was quadricuspid and dysplastic; associated anomalies were a right subclavian artery arising anomalously from the descending aorta, a single coronary artery, an absent ductus arteriosus and a small persistent left cranial (superior) vena cava. The truncus cushions were hypoplastic, had failed to fuse and each had simply produced an arterial cusp. The observations made on this embryo support the view that in persistent truncus arteriosus there is failure of septation of the truncus arteriosus. No evidence was found in favor of the concept that persistent truncus arteriosus represents a form of tetralogy of Fallot with atresia of the subpulmonary infundibulum and partial or complete absence of the aorticopulmonary septum.
mesh_terms: D000818:Animals; D003330:Coronary Vessel Anomalies / Q000196:embryology / Q000662:veterinary; D004283:Dog Diseases / Q000196:embryology* / Q000473:pathology; D004285:Dogs; D009206:Myocardium / Q000473:pathology; D013771:Tetralogy of Fallot / Q000473:pathology; D014339:Truncus Arteriosus, Persistent / Q000196:embryology / Q000473:pathology / Q000662:veterinary*