Effect of cortisone or triiodothyronine administration to pregnant rats on lysosomal hydrolases in fetal forebrain and cerebellum.
Triiodothyronine injected daily to pregnant rats for the last week of gestation (50 microgram/100 g b.wt) increased the specific activities of 5 acid glycosidases in the fetal forebrain and cerebellum. Cortisone (50 mg/100 g b.wt) administered in the same period had no effect on cerebellum acid hydrolases, but decreased their activity in the forebrain.
D000818:Animals; D001921:Brain / Q000196:embryology / Q000201:enzymology*; D002531:Cerebellum / Q000201:enzymology; D003348:Cortisone / Q000494:pharmacology*; D005260:Female; D005333:Fetus / Q000201:enzymology*; D006026:Glycoside Hydrolases / Q000378:metabolism*; D008247:Lysosomes / Q000201:enzymology; D011247:Pregnancy; D051381:Rats; D014284:Triiodothyronine / Q000494:pharmacology*
D014284:Triiodothyronine; D006026:Glycoside Hydrolases; D003348:Cortisone