title: [Dynamics of dominant lethal mutations in male mice exposed to cyclophosphamide in drinking water for different periods of time].
abstract: The dependence of induction of dominant lethal mutations in male mice on the duration of exposure (from 1 to 12 weeks) to 0.01% aqueous solution of cyclophosphamide was studied. The maximal frequency of dominant lethal mutations was observed when males treated were crossed during the first week after the end of exposure. The yield of dominant lethal mutations did not depend on the duration of the exposure of cyclophosphamide.
mesh_terms: D000818:Animals; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004326:Drinking; D005799:Genes, Dominant; D005804:Genes, Lethal; D008297:Male; D051379:Mice; D009153:Mutagens / Q000633:toxicity*; D009154:Mutation; D013997:Time Factors
chemical_list: D009153:Mutagens; D003520:Cyclophosphamide
vernacular_title: Dinamika dominantnykh letal'nykh mutatsiĭ u samtsov mysheĭ pri raznykh srokakh ékspozitsii tsiklofosfamida v pit'evoĭ vode.