Evolution of intrathoracic airway mechanics during lung growth.
Elastic recoil pressure of the lungs (Pst(L)), maximum expiratory flow rates (MEF), critical transmural pressure of the collapsible flow-limiting segment (Ptm'), and S-segment conductance (Gs) have been determined in 40 healthy subjects, 7-18 yr old. Pst(L), measured at different lung volumes (fractional) from the expiratory quasi-static pressure-volume curves, increases progressively with age. MEF's, at different lung volumes, are closely related to total lung capacity (TLC); the ratios MEF/TLC, at all lung volumes, are independent of age. Ptm' is also independence of age and body height, most values lying between 0 and -15 cmH2O; this finding suggests that the locus and the behavior of the collapsible segment do not change during growth. Gs, in absolute value, increases with growth but, when adjusted for lung size, Gs decreases steadily with age and body height. These relations suggest that, from childhood to adolescence, the air spaces grow disproportionately more than the airway system.
D000293:Adolescent; D001980:Bronchi / Q000254:growth & development; D002648:Child; D005260:Female; D006801:Humans; D008168:Lung / Q000254:growth & development* / Q000502:physiology; D008170:Lung Compliance; D008176:Lung Volume Measurements; D008297:Male; D008448:Maximal Expiratory Flow Rate; D011650:Pulmonary Alveoli / Q000254:growth & development; D012123:Pulmonary Ventilation