Quantitative analysis of 6,11-dihydro-11-oxo-dibenz[b,e] oxepin-2-acetic acid (isoxepac) in plasma and urine by gas--liquid chromatography.
A method is described for the quantitative analysis of 6,11-dihydro-11-oxo-dibenz[b,e]-oxepin-2-acetic acid (isoxepac) in plasma and urine. Isoxepac and internal standard was analysed by gas-liquid chromatography using a flame ionization detector. The method is accurate and precise over the range 0.1--30 microgram/ml. The method has been applied to the analysis of plasma and urine from both healthy volunteers and patients receiving therapeutic oral doses of isoxepac.
D000085:Acetates / Q000097:blood / Q000652:urine; D000893:Anti-Inflammatory Agents / Q000032:analysis* / Q000097:blood / Q000652:urine; D002849:Chromatography, Gas; D002853:Chromatography, Liquid; D003990:Dibenzoxepins / Q000032:analysis* / Q000097:blood / Q000652:urine; D006801:Humans
D000085:Acetates; D000893:Anti-Inflammatory Agents; D003990:Dibenzoxepins; C014904:isoxepac