Gastrin stimulated H+ secretion in amphibian gastric mucosa: effect of tetrodotoxin.
The role of neural mechanisms in gastrin stimulated H+ secretion was studied using amphibian gastric fundic mucosa. Spontaneously secreting mucosae were converted to resting state (zero H+ secretory rate) using Burimamide. Following removal of burimamide, 3 X 10(-6) M tetrodotoxin did not block gastrin stimulation of H+ secretion indicating that neural mechanisms are not required.
D000818:Animals; D001001:Anura; D002049:Burimamide / Q000494:pharmacology; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects*; D008297:Male; D010418:Pentagastrin / Q000494:pharmacology*; D013779:Tetrodotoxin / Q000494:pharmacology*
D013779:Tetrodotoxin; D010418:Pentagastrin; D002049:Burimamide