title: Distribution of fibres reacting with an alpha-endorphin antiserum in the neurohypophysis of Carassius auratus and Cyprinus carpio.
abstract: A strong positive immunoreaction with an alpha-endorphin antiserum occurs in two distinct sites of the goldfish and carp neurohypophysis. Fluorescent nerve terminals are found in the laminar nerve processes located in the rostral pars distalis, but the immunocytological reaction is mainly localised on the nerve processes of the posterior neurohypophysis lying between the intermediate lobe cells. Almost all the digitations of the neurohypophysis are strongly fluorescent. The immunoreactive fibres probably originate from the hypothalamus, where perikarya displaying the same immunoreaction have been found in the pars lateralis of the nucleus lateralis tuberis and in some minor centres. The possibility that the immunoreactive substances revealed on the neurohypophyseal processes may originate in the intermediate lobe cells is also discussed. It has now to be established if this hypothalamo-hypophyseal system contains a substance with endorphic properties or only some immunologically related substance devoid of the corresponding physiological activities.
mesh_terms: D000818:Animals; D002347:Carps / Q000033:anatomy & histology*; D003530:Cyprinidae / Q000033:anatomy & histology*; D004723:Endorphins / Q000276:immunology*; D006054:Goldfish / Q000033:anatomy & histology*; D007106:Immune Sera; D009411:Nerve Endings / Q000276:immunology; D009412:Nerve Fibers / Q000276:immunology*; D010904:Pituitary Gland, Posterior / Q000294:innervation*
chemical_list: D004723:Endorphins; D007106:Immune Sera