[Coagulation factors and thrombocytes after application of Reptilase in the course of gynecologic operations (author's transl)].
Hemostasiologic effects of intravenous application of Reptilase were investigated in a randomized double blind study in the course of normal abdominal and vaginal hysterectomies. Coagulation factors and thrombocytes were checked before, after, 40 minutes after as well as 24 hours after the operation. Significant shortening of the clot observation time resulted 40 minutes after the injection of 1 ml Reptilase. A small but highly significant decrease of thrombocytes was observed 40 minutes after the end of the operation when Reptilase was injected. Further coagulation screening tests: Quick test, PTT and thrombin time were without statistically differences in both patients groups from the beginning till 24 hours after the operation. A significant decrease in Factor V concentrations resulted 40 minutes after the injection of Reptilase, whereas no changes were seen in the placebo patient group. Too, Factor XIII values and Antithrombin 3 concentrations decreased after the administration of Reptilase. There was no abnormal raise of fibrin-monomers in both groups. Enhanced fibrinolysis with elevated FDP-levels were measured in none of the cases. The administration of Reptilase induced a short lasting augmentation of blood coagulation but without any signs of disseminated intravascular coagulation.
D000328:Adult; D012103:Batroxobin / Q000008:administration & dosage*; D001777:Blood Coagulation / Q000187:drug effects; D001779:Blood Coagulation Factors / Q000032:analysis; D001780:Blood Coagulation Tests; D001792:Blood Platelets / Q000187:drug effects; D004211:Disseminated Intravascular Coagulation; D005169:Factor VIII / Q000032:analysis; D005260:Female; D005831:Genital Diseases, Female / Q000601:surgery*; D006801:Humans; D008875:Middle Aged; D010447:Peptide Hydrolases / Q000008:administration & dosage*; D013997:Time Factors
D001779:Blood Coagulation Factors; D005169:Factor VIII; D010447:Peptide Hydrolases; D012103:Batroxobin
Gerinnungsfaktoren und Thrombozyten nach Gabe von Reptilase bei gynäkologischen Standardoperationen.