title: Are anticholinergic effects responsible for the heterogeneous quinidine-induced modifications of heart muscle refractoriness?
abstract: Vagal tone is responsible for the heterogeneous reactivity of atrial and ventricular contractile tissues to quinidine. Acetylcholine may make atrial cells more sensitive to the effects of quinidine.
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D004285:Dogs; D009200:Myocardial Contraction / Q000187:drug effects*; D011802:Quinidine / Q000494:pharmacology*; D014628:Vagotomy
chemical_list: D001285:Atropine; D011802:Quinidine; D000109:Acetylcholine