title: [Mechanism of action of Novocain administered intravenously to animals].
abstract: Tests conducted with 48 dogs and 100 rabbits demonstrated that intravenous administration of novocain has a well-marked positive influence in extreme conditions, such as massive blood losses and traumatic shocks. It is shown that in the mechanism of the drug's action particularly important is its capability to increase the cardiac performance, to eliminate spasms of resistive vessels and to contract the blood-carrying vessels of the microcirculatory stream. The final effect, however, is in a great measure dependent upon the initial functional state of the organism (the period of hemorrhagic or traumatic shock) and an early introduction of the drug.
mesh_terms: D000208:Acute Disease; D000818:Animals; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D007275:Injections, Intravenous; D008297:Male; D011343:Procaine / Q000627:therapeutic use*; D011817:Rabbits; D012771:Shock, Hemorrhagic / Q000188:drug therapy; D012774:Shock, Traumatic / Q000188:drug therapy; D013997:Time Factors
chemical_list: D011343:Procaine
vernacular_title: K mekhanizmu deĭstviia novokaina pri vnutrivennom vvedenii ego zhivotnym.