title: [Kinetic and spectral parameters of the amines oxidative N-dealkylation with participation of the liver microsomal cytochrome P-450. Amines oxidation with organic hydroperoxides].
abstract: Kinetics of demethylation of a number of amines involving hepatic microsomal cytochrome P-450 and organic hydroperoxides (tret-butyl- and cumylhydroperoxide) have been investigated. Decomposition rate constants for the substrate-cytochrome P-450-ROOH complexes have been determined in a generalized form. Activation parameters, deltaH* and deltaS*, are calculated for decomposition of the complexes. There is a linear relation between deltaH* and deltaS*: deltaH*=18.7 kcal + 333 degrees K deltaS*. Compensation relationship is characterized by the value of alpha=333 degrees K/Taverage=1.11. The nature of the limiting step in the cytochrome P-450-NADPH-O2-system and the cytochrome P-450-ROOH-system is discussed.
mesh_terms: D000588:Amines / Q000378:metabolism*; D000814:Aniline Compounds / Q000378:metabolism; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D003640:Dealkylation; D007700:Kinetics; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism*; D010089:Oxidoreductases, N-Demethylating / Q000378:metabolism; D010545:Peroxides / Q000378:metabolism*; D051381:Rats; D013816:Thermodynamics
chemical_list: D000588:Amines; D000814:Aniline Compounds; D010545:Peroxides; D003577:Cytochrome P-450 Enzyme System; D010089:Oxidoreductases, N-Demethylating
vernacular_title: Kineticheskie i spektral'nye parametry reaktsii okislitel'nogo N-dealkilirovaniia aminov s uchastiem tsitokhroma P-450 mikrosom pecheni. Okislenie aminov organicheskimi gidroperekisiamí.