Influence of theophylline on the diameter of the afferent glomerular arteriole of the rat.
After agar-agar and india ink mixture intrarenal injection, it is possible to measure precisely the glomerular afferent arteriole diameter and to evaluate its variations after theophylline perfusion. The increased diameter (+ 35.78%) confirms the peripheral vasodilating theophylline effect, often assumed, but never to our knowledge proven in situ.
D000818:Animals; D001158:Arteries / Q000033:anatomy & histology*; D001160:Arterioles / Q000033:anatomy & histology* / Q000187:drug effects; D007678:Kidney Glomerulus / Q000098:blood supply*; D010477:Perfusion; D051381:Rats; D013806:Theophylline / Q000494:pharmacology; D014664:Vasodilation
D013806:Theophylline