title: Studies on mast cells of Rana tigrina.
abstract: Mast cell degranulators cause vasoconstriction in the frog. A comparative study of the mesenteric mast cells of the frog and rat showed that the frog mast cells differed from those of the rat in having a dense perigastric instead of a sparse ideal distribution, and in responding to compound 48/80 by a rapid and marked disappearance and/or fragmented appearance instead of classical degranulation. The vasoconstriction and mast cell response after in vivo compound 48/80 appeared related since they showed a parallel increase when the dose was increased.
mesh_terms: D000818:Animals; D001001:Anura; D003594:Cytoplasmic Granules / Q000187:drug effects; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000648:ultrastructure*; D012313:RNA; D051381:Rats; D014661:Vasoconstriction / Q000187:drug effects; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
chemical_list: D003189:p-Methoxy-N-methylphenethylamine; D012313:RNA