Inhibition of 1,2-dimethylhydrazine-induced neoplasia of the large intestine in female CF1 mice by carbon disulfide.
Disulfiram, diethyldithiocarbamate, and bis-(ethylxanthogen) inhibit symmetrical 1,2-dimethylhydrazine dihydrochloride (DMH)-induced neoplasia of the large bowel in female CF1 mice. These three compounds contain a carbon disulfide (CS2) moiety in their structure. In the present study, CS2 itself was found to inhibit DMH-induced neoplasia of the large bowel in female CF1 mice. Thus a relatively simple compound is now available for investigation of the mechanism of inhibition of DMH-induced neoplasia by a group of sulfur-containing inhibitors having common structural features.
D000230:Adenocarcinoma / Q000139:chemically induced; D000236:Adenoma / Q000139:chemically induced; D000818:Animals; D002246:Carbon Disulfide / Q000494:pharmacology*; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced; D004127:Dimethylhydrazines / Q000037:antagonists & inhibitors*; D005260:Female; D007414:Intestinal Neoplasms / Q000139:chemically induced*; D008763:Methylhydrazines / Q000037:antagonists & inhibitors*; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced
D004127:Dimethylhydrazines; D008763:Methylhydrazines; D002246:Carbon Disulfide