title: [Taurocholic acid synthesis in dogs maintained on a high cholesterol diet].
abstract: Labeled 35S-taurocholic acid synthesis was studied in dogs with gall bladder fistulae, fed high cholesterol diet. During the first period (1--2 months) dietary cholesterol caused a significant increase in the 35S-taurocholic acid synthesis. In 5--6 months, at the period of development of the pathological process in the liver, there was a decrease of synthesis and secretion of bile acids, and of cholesterol sediment in the bile. The level of plasma cholesterol in these dogs increased only slightly.
mesh_terms: D000818:Animals; D002791:Cholesterol, Dietary / Q000008:administration & dosage*; D004285:Dogs; D008099:Liver / Q000378:metabolism*; D008107:Liver Diseases / Q000378:metabolism*; D013656:Taurocholic Acid / Q000096:biosynthesis*; D013997:Time Factors
chemical_list: D002791:Cholesterol, Dietary; D013656:Taurocholic Acid
vernacular_title: Sintez taurokholevoĭ kisloty pri soderzhanii sobak na giperkholesterinovoĭ diete.