Mutant hemoglobins having elongated chains.
Globin subunits may be elongated because of a base substitution in the termination codon, a crossover out of phase (frame shift) or a crossover in phase. This review presents structural, genetic, biosynthetic and clinical information on the eight variants having elongated chains which have been described to date.
D000595:Amino Acid Sequence; D001483:Base Sequence; D003062:Codon; D005914:Globins; D006455:Hemoglobins, Abnormal / Q000096:biosynthesis / Q000235:genetics* / Q000378:metabolism; D009154:Mutation; D012333:RNA, Messenger; D013789:Thalassemia / Q000097:blood
D003062:Codon; D006455:Hemoglobins, Abnormal; D012333:RNA, Messenger; D005914:Globins