Lymphocyte cytotoxicity in the X-irradiation induced rat small bowel adenocarcinoma. II. Presence of cytotoxic lymphocytes in irradiated animals.
Cytotoxic peripheral blood lymphoid cells were demonstrated in both Holtzman and Lewis Brown-Norway rats which had received 2000R of local X-irradiation to the temporarily hypoxic, exteriorized, ileum and jejunum regardless of whether a small bowel adenocarcinoma subsequently developed. The cytotoxic response, which was detectable at two days, was quite evident by day 5 post-irradiation. No evidence of cross-reacting tumor antigens was obtained when similarly processed effector cells from Holtzman rats bearing a spontaneous mammary carcinoma were incubated with cell cultures derived from the small bowel adenocarcinoma. These findings indicate X-irradiation of the small bowel initiates lymphocyte sensitization that is manifested as in vitro cytotoxicity against cell cultures of the adenocarcinoma.
D000230:Adenocarcinoma / Q000209:etiology / Q000276:immunology*; D000818:Animals; D003602:Cytotoxicity, Immunologic / Q000528:radiation effects*; D066298:In Vitro Techniques; D007414:Intestinal Neoplasms / Q000209:etiology / Q000276:immunology*; D007421:Intestine, Small; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D009374:Neoplasms, Experimental / Q000276:immunology; D009381:Neoplasms, Radiation-Induced / Q000276:immunology*; D051381:Rats; D013997:Time Factors; D014965:X-Rays