Pancreatic hormones and plasma glucose: regulation mechanisms in the goose under physiological conditions. II. Glucose-glucagon and glucose-insulin feed-back mechanisms.
We have studied the pancreatic hormone-glucose feed-back mechanisms by infusing glucagon (G), insulin (I) and glucose into normal fasting geese. The controls received saline. Whilst a NaCl 9% infusion is devoid of effect, the pancreatic hormones, used at physiological doses, modify the plasma glucose level, glucagon being hyperglycaemic and insulin hypoglycaemic. In addition, a physiological increase in plasma glucose provokes a drop in plasma glucagon and a rise in plasma insulin, thus a marked decrease in the G/I ratio. The results show that the pancreatic hormone-glucose feed-back mechanisms are effective under physiological conditions.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D005246:Feedback; D005260:Female; D005777:Geese / Q000378:metabolism*; D005934:Glucagon / Q000008:administration & dosage / Q000502:physiology*; D007263:Infusions, Parenteral; D007328:Insulin / Q000008:administration & dosage / Q000502:physiology*; D008297:Male
D001786:Blood Glucose; D007328:Insulin; D005934:Glucagon