Unstable angina pectoris: a randomized study of patients treated medically and surgically.
Fifty patients with the clinical syndrome of unstable angina pectoris were evaluated. Twenty-seven were randomized into medical or surgical treatment groups and subsequently followed up. The results of the study reveal that: (1) there is approximately a 16 percent incidence rate of significant left main coronary artery disease in patients with this entity at our institution; (2) 10 percent of patients do not have angiographically significant coronary artery disease; (3) pain relief is better in the surgically treated patients, but the 1 1/2 year survival rate is not significantly different between the groups; (4) 50 percent of the medically treated patients again had the syndrome of unstable angina pectoris in the initial few months of the follow-up period; (5) the operative and late postoperative mortality rate in patients presenting with unstable angina pectoris and left main coronary artery disease in this small group of patients was 43 percent; and (6) four of six patients with this syndrome whose condition was deemed inoperable and who were not randomized died within the subsequent few months.
D000787:Angina Pectoris / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery*; D006328:Cardiac Catheterization; D003327:Coronary Disease / Q000188:drug therapy / Q000401:mortality / Q000601:surgery; D005080:Exercise Test; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007548:Isosorbide Dinitrate / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009204:Myocardial Revascularization; D011433:Propranolol / Q000627:therapeutic use
D011433:Propranolol; D007548:Isosorbide Dinitrate