[Dependence of nitrazepam metabolism on the method of its administration and species of experimental animals].
Intraperitoneal, intravenous and peroral administration of nitrasepam has no effect on its transformation and distribution in the liver tissues, blood and brain of mice. Depending on the products of nitrasepam transformation formed in the animal liver, the enzymic systems providing such transformations have species peculiarities: the rat liver tissues contain nitroreductase, N-acetyl-transferase and desacetylase. And the mice tissues contain only nitroreductase and desacetylase.
D000123:Acetyltransferases / Q000378:metabolism; D000284:Administration, Oral; D000818:Animals; D001921:Brain / Q000378:metabolism; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D051379:Mice; D009567:Nitrazepam / Q000008:administration & dosage / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism; D051381:Rats; D013045:Species Specificity
D009567:Nitrazepam; D010088:Oxidoreductases; D000123:Acetyltransferases
Zavisimost' metabolizma nitrazepama ot sposoba ego vvedeniia i vida eksperimental'nykh zhivotnykh.