The histological effect of an ovarian growth factor on ovarian follicle development in immature mice.
The effect of an ovarian growth factor (OGF) purified from bovine pituitary glands was tested in vivo in immature mice from twelve to nineteen days old. Differential count of ovarian follicles was taken as a morphologic parameter for OGF effect upon ovarian maturation. Results obtained suggest that OGF injection increases the number of small secondary follicles which leave the pool of non-growing follicles, but does not promote follicle cell luteinization nor present follicle degeneration.
D000818:Animals; D005260:Female; D005640:Follicle Stimulating Hormone / Q000494:pharmacology*; D006133:Growth Substances / Q000494:pharmacology / Q000502:physiology*; D051379:Mice; D006080:Ovarian Follicle / Q000187:drug effects* / Q000254:growth & development / Q000648:ultrastructure; D010053:Ovary / Q000166:cytology / Q000502:physiology*
D006133:Growth Substances; D005640:Follicle Stimulating Hormone