Comparative haemodynamic effects of clonidine administered intramuscularly or intravenously to anaesthetized rats.
1. The acute haemodynamic effects of clonidine, 0.001-1.0 mg/kg, administered intramuscularly or intravenously, were studied in anaesthetized rats. 2. The direct pressor potency of clonidine was 100-fold greater following intravenous administration than after intramuscular injection, but hypotensive efficacy was equal by either route.
D000818:Animals; D003000:Clonidine / Q000008:administration & dosage / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects*; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D051381:Rats
D003000:Clonidine