Studies on myocardial histamine. Effects of catecholamine-depleting drugs.
Hearts of rats, mice and guinea-pigs were assayed in parallel for histamine and norepinephrine. Reserpine decreased the histamine content in the hearts of rats and mice but not in guinea-pigs. alpha-Methyltyrosine decreased the histamine content in both rat and guinea-pig hearts. 6-Hydroxydopamine increased myocardial histamine content in the rat but not in the mouse.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D002395:Catecholamines / Q000378:metabolism*; D006168:Guinea Pigs; D006632:Histamine / Q000378:metabolism*; D006892:Hydroxydopamines / Q000494:pharmacology; D066298:In Vitro Techniques; D008168:Lung / Q000378:metabolism; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology; D051379:Mice; D009206:Myocardium / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D012110:Reserpine / Q000494:pharmacology
D002395:Catecholamines; D006892:Hydroxydopamines; D008781:Methyltyrosines; D006632:Histamine; D012110:Reserpine; D009638:Norepinephrine