The maternal distribution and placental transfer of cadmium in zinc deficient rats.
Although a transitory maternal zinc deficiency has been shown to result in an increased cadmium-induced fetotoxicity, the results of the present investigation indicated that a maternal zinc deficiency apparently did not affect the placental transfer of cadmium. However, a zinc deficiency did alter the maternal distribution of cadmium. The increased cadmium fetotoxicity associated with a maternal zinc deficiency may be caused by a maternal alteration rather than a direct effect on the fetus. Further study is necessary prior to any definitive statement concerning the effects of a maternal zinc deficiency on cadmium fetotoxicity.
D000818:Animals; D002104:Cadmium / Q000378:metabolism*; D005260:Female; D005333:Fetus / Q000378:metabolism; D005865:Gestational Age; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D051381:Rats; D013997:Time Factors; D015032:Zinc / Q000172:deficiency*
D002104:Cadmium; D015032:Zinc