Treatment of Goodpasture's disease by plasma exchange and immunosuppression.
Three cases of Goodpasture's disease are described who were treated with intensive plasma exchange and immunosuppression. There was no improvement in renal function and the patients required chronic haemodialysis, but renal function did recover with treatment for recurrence of disease in a transplanted kidney. Anti-GBM antibody levels were not controlled and substantial reduction in fibrinogen and complement were only achieved with daily treatment. A controlled trial of this regime is urgently required.
D000328:Adult; D019867:Anti-Glomerular Basement Membrane Disease / Q000276:immunology / Q000628:therapy*; D000906:Antibodies / Q000032:analysis; D005078:Exchange Transfusion, Whole Blood; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged
D000906:Antibodies; D007074:Immunoglobulin G; D007166:Immunosuppressive Agents