Synergistic cytotoxicity for L929 cells of polyriboinosinic-polyribocytidylic acid and amphotericin B methyl ester.
A synergistic impairment in cell growth of L929 mouse fibroblasts resulted from treatment with a combination of amphotericin B methyl ester and polyriboinosinic-polyribocytidylic acid. This effect, which may result from the altered membrane permeability induced by polyenes, may augment the therapeutic efficacy of polyribonucleotides as antitumor compounds.
D000666:Amphotericin B / Q000031:analogs & derivatives* / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects*; D003864:Depression, Chemical; D004357:Drug Synergism; D007739:L Cells; D011070:Poly I-C / Q000494:pharmacology*
C017501:methylamphotericin B; D000666:Amphotericin B; D011070:Poly I-C