[Effect of cytostatic agents on the metabolism and ultrastructure of blood platelets in man].
The effect of cytostatic drugs used in the treatment of haemopoietic system diseases: cerubidin, hydroxyurea. cytosine arabinoside and their combinations on the platelet count, platelet ultrastructure, metabolic activity and participation in the processes of haemostasis was investigated. The experiments were done using two concentrations of the drugs: clinical corresponding to the maximal single dose and a fivefold as high concentration, It was found that the investigated cytostatic agents and their cominations in the first concentration had no effect of the platelet count, level of free nucleotides, activity of glucose-6-phosphate dehydrogenase and lactic dehydrogenase, and on the reaction of adenine nucleotides release from the platelets induced with thrombin. Using the higher concentration of the drugs it was observed that cerubidin and the combination of cytostatic agents tested changed the shape and ultrastructure of the platelets.
D000970:Antineoplastic Agents / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D003561:Cytarabine / Q000494:pharmacology; D003630:Daunorubicin / Q000009:adverse effects; D006487:Hemostasis; D006801:Humans; D006918:Hydroxyurea / Q000494:pharmacology
D000970:Antineoplastic Agents; D003561:Cytarabine; D006918:Hydroxyurea; D003630:Daunorubicin
Wpływ leków cytostatycznych na metabolizm i ultrastrukture krwinek płytkowych człowieka.