The uptake of 3H(G)L leucine into single muscle fibers in Charcot-Marine-Tooth disease.
In previous studies, the incorporation of 3H(G)L-leucine into muscles of patients with Charcot-Marie-Tooth (CMT) disease was shown to be increased in comparison with that observed in motor neuron disease (MND). To determine the cause of the increased uptake in CMT, studies of single fiber leucine incorporations have been undertaken. The results of this study indicate that the increased incorporation is into those muscle fibers which are undergoing regeneration following reinnervation. These results do not support the thesis that there is an associated myopathic process in CMT.
D002607:Charcot-Marie-Tooth Disease / Q000378:metabolism*; D006651:Histocytochemistry; D006801:Humans; D007866:Leg; D007930:Leucine / Q000378:metabolism*; D009046:Motor Neurons; D009132:Muscles / Q000378:metabolism*; D009133:Muscular Atrophy / Q000378:metabolism*; D009468:Neuromuscular Diseases / Q000378:metabolism
D007930:Leucine