title: Depression of mitogen response in spleen cells from reticuloendotheliosis virus-infected chickens and their suppressive effect on normal lymphocyte response.
abstract: Spleen cells and peripheral blood lymphocytes from chickens infected with reticuloendotheliosis virus (REV) were depressed in their responsiveness to phytohemagglutinin (PHA). When spleen cells from uninfected chickens were co-cultured with spleen cells from chickens infected with REV at 2 weeks of age, the PHA response by the normal cells was completely suppressed. Although spleen cells from chickens infected with REV at 6 or 9 weeks of age were also suppressed in their ability to respond to PHA, they did not suppress the mitogenic response of normal cells in mixed cultures.
mesh_terms: D000375:Aging; D000818:Animals; D002645:Chickens; D007165:Immunosuppression Therapy; D037102:Lectins / Q000494:pharmacology; D008206:Lymphatic Diseases / Q000276:immunology*; D008213:Lymphocyte Activation; D008934:Mitogens / Q000494:pharmacology*; D013154:Spleen / Q000276:immunology*
chemical_list: D037102:Lectins; D008934:Mitogens