Studies of the effect of 5alpha-androstane-3alpha,17alpha-diol in the canine prostate in vivo.
Adult beagle dogs, castrated one month previously, were treated with 5alpha-androstane-3alpha,17alpha-diol (total dose 300 mg) over a period of one month. Examination of the prostate after treatment showed no significant change in size, weight or histological appearance from the castrate dog prostate. Subsequent administration of 5alpha-androstane-3alpha,17beta-diol (300 mg) over the same period of time resulted in restoration of the prostate size, weight and histological appearance to that of the normal intact dog prostate. It is concluded that exogenously administered 5alpha-androstane-3alpha,17alpha-diol does not promote prostatic growth in the castrate beagle dog.
D015113:Androstane-3,17-diol / Q000494:pharmacology*; D000731:Androstanes / Q000494:pharmacology*; D000818:Animals; D002369:Castration; D004285:Dogs; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011467:Prostate / Q000187:drug effects / Q000502:physiology*
D000731:Androstanes; D015113:Androstane-3,17-diol