Genetic counseling of consanguineous families. Use of Smith's method to calculate recurrence risks in multifactorial inheritance in consanguineous matings.
A modification of Smith's method is described for deriving recurrence risks for multifactorial conditions when parents are related. Using cleft palate as an example, the possible increased risks caused by consanguinity are discussed.
D003241:Consanguinity; D005817:Genetic Counseling; D030342:Genetic Diseases, Inborn / Q000235:genetics; D006801:Humans; D008433:Mathematics; D010375:Pedigree; D012008:Recurrence; D012306:Risk