title: [Neurotropic activity of phenylpyrrolidones-2].
abstract: Experiments were conducted on mice and rats; a study was made of the pharmacological activity of three isomers of phenyl derivatives of pyrrolidone-2 (P-2). The latter represented a cylic form of gamma-aminobutyric acid (GABA). All the three preparations suppressed the motor activity, decreased the muscle tone and the body temperature, potentiated the action of hexenal, possessed the antispasmodic and hypnotic activity. 4-phenyl-pyrrolidone-2 (phepyron) proved to be most active. In comparing the pharmacological activity of phenyl P-2 derivatives and analogous GABA derivatives the latter were found to possess no antispasmodic or hypnotic activity, and were less toxic. It is supposed that no transformation of phenyl P-2 derivatives into analogous GABA derivatives occurred in the organism.
mesh_terms: D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D006993:Hypnotics and Sedatives; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D009129:Muscle Tonus / Q000187:drug effects; D010276:Parasympatholytics; D011760:Pyrrolidinones / Q000494:pharmacology*; D051381:Rats
chemical_list: D006993:Hypnotics and Sedatives; D010276:Parasympatholytics; D011760:Pyrrolidinones
vernacular_title: Neĭrotropnaia aktivnost' fenil-pirrolidonov-2.