Effects of riboflavin-2',3',4',5'-tetrabutyrate and flavin adenine dinucleotide on the platelet aggregation induced by hydrogen peroxide.
Both riboflavin-2',3',4',5'-tetrabutyrate and flavin adenine dinucleotide (FAD), especially the latter, could inhibit H2O2-induced platelet aggregation. FAD enhanced the glutathione reductase activity of platelets. FAD might exert its inhibitory effect on the H2O2-induced platelet aggregation via the glutathione reductase and peroxidase system.
D000293:Adolescent; D001792:Blood Platelets / Q000201:enzymology; D002087:Butyrates / Q000494:pharmacology; D005182:Flavin-Adenine Dinucleotide / Q000494:pharmacology*; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D006801:Humans; D006861:Hydrogen Peroxide / Q000037:antagonists & inhibitors*; D066298:In Vitro Techniques; D010974:Platelet Aggregation / Q000187:drug effects*; D012256:Riboflavin / Q000031:analogs & derivatives* / Q000494:pharmacology
D002087:Butyrates; D005182:Flavin-Adenine Dinucleotide; D006861:Hydrogen Peroxide; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D012256:Riboflavin