[Kinetics of accumulation and elimination of 14C-dipine, an antineoplastic drug].
An investigation on evaluating the distribution of 14C-dipine in rats with sarcoma 45 was carried out. With intragastric administration of the drug its resorption occurs largely in the small intestine. The maximally absorbed portion of the tag is detected in 1 hour and by this time it reaches 36.4 per cent of the introduced radioactivity. The share of the tumour is 2,32 per cent (coefficent of radioactivity absorption CA-0.42). Tests involving washing of the vascular system enabled it to ascertain a rather weak bonding of the drug with the tissues. The results of the CA comparison in the blood and tissues indirectly suggests that the accumulation of radioactivity takes place not only at the expense of its presence in the blood but also because of its penetration into the structural formations of the cells. A mathematical modelling that features the presence of 14C-dipine in terms of time (CA/hour) showed that with intragastric as against intravenous administration of the drug the fibure under consideration was higher for a number of organs and tissues. A feature common to 14C-dipine is to become accumulated in the organism with its daily administration for 3 days. With its intragastric administration 14C-dipine is eleminated, argely via the kidneys, in the course of 13 hours, which is its half-decay time.
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000378:metabolism*; D001388:Aziridines / Q000008:administration & dosage / Q000378:metabolism*; D001389:Azirines / Q000378:metabolism*; D002250:Carbon Radioisotopes; D006207:Half-Life; D007275:Injections, Intravenous; D007441:Intubation, Gastrointestinal; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D008954:Models, Biological; D010879:Piperazines / Q000008:administration & dosage / Q000378:metabolism; D051381:Rats; D012513:Sarcoma, Experimental / Q000378:metabolism; D013997:Time Factors; D014018:Tissue Distribution
D000970:Antineoplastic Agents; D001388:Aziridines; D001389:Azirines; D002250:Carbon Radioisotopes; D010879:Piperazines
Kinetika nakopleniia i vyvedeniia protivoopukholevogo preparata 14C-dipina.