Dihydroergotoxine(Hydergine) and ethanol-induced aging of C57BL/6J male mice.
The residual effects of dihydroergotoxine (Hydergine), ethanol, and Hydergine-plus-ethanol were investigated in old male mice of the C57BL/6J strain. Prolonged 10% v/v ethanol, concomitant with adequate nutrition, produced a significant decrease in life-span, decreased spontaneous locomotor activity and reduced lipofuscin accumulation in neurons of the reticularis gigantocellularis. These effects were not apparent in mice treated with Hydergine or alcohol combined with Hydergine.
D000375:Aging / Q000187:drug effects*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000473:pathology; D004088:Dihydroergotoxine / Q000494:pharmacology*; D000431:Ethanol / Q000494:pharmacology*; D008124:Locomotion / Q000187:drug effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009474:Neurons / Q000473:pathology; D009929:Organ Size / Q000187:drug effects; D013997:Time Factors
D004088:Dihydroergotoxine; D000431:Ethanol