[Circadian periodicity and stomach ulcer. An animal experiment model for the detection of rhythm factors in the genesis of civilization diseases].
Against the background of clinical experience attesting to the role of the circadian and circannual rhythm stage in gastric ulcerogenesis, animal experiments provide a model where by circadian stage and sex are both revealed as determinants of gastric ulcerogenesis. Experiments on the genetically mesor-hypertensive Okamoto rat demonstrate the critical interaction of multiple loads in ulcerogenesis, in keeping with a report by Glavin and Mikhail. While stimulation by single loads of a certain intensity--immobilization, food deprivation or cooling--did not regularly lead to the production of gastric ulcers, the combination of these same loads did so as a function of circadian state at the beginning of exposure time.
D000818:Animals; D002940:Circadian Rhythm; D004195:Disease Models, Animal; D004781:Environmental Exposure; D006801:Humans; D051381:Rats; D013276:Stomach Ulcer / Q000209:etiology*
Zirkadian-Periodik und Magengeschwür. Ein tierexperimentelles Modell zum Nachweis von rhythmischen Faktoren in der Genese von Zivilisationskrankheiten.