title: Clinical correlates of tricyclic antidepressant-mediated inhibition of platelet monoamine oxidase.
abstract: Previous reports suggest that tricyclic antidepressants inhibit platelet monoamine oxidase (MAO) activity in vitro and in vivo. This study was undertaken to examine the relationship between tricyclic-mediated inhibition of platelet MAO and resolution of clinical signs and symptoms which are commonly associated with the depressive syndrome. The results indicate that the sedative-hypnotic effects of the tricyclics closely correlate with the magnitude of platelet MAO inhibition. It appears that these effects may be mediated through alterations in the metabolism of serotonin and/or the phenylethylamines.
mesh_terms: D000328:Adult; D000639:Amitriptyline / Q000627:therapeutic use*; D001792:Blood Platelets / Q000201:enzymology*; D003863:Depression / Q000188:drug therapy / Q000201:enzymology*; D003864:Depression, Chemical; D006801:Humans; D007099:Imipramine / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000097:blood*
chemical_list: D000639:Amitriptyline; D008995:Monoamine Oxidase; D007099:Imipramine