title: Biological reaction to carbon fiber implants: the formation and structure of a carbon-induced "neotendon".
abstract: In 43 young rabbits, the tendo Achilles and flexor digitorum longus tendon were excised and replaced by filamentous carbon fiber. Tendo-Achilles in controls was repaired by silk or nylon sutures or left without replacement. Concurrent excision of the posterior tibial nerve was performed in one group of the carbon-replacing tendo-Achilles operations. When fully functioning, carbon-induced "neotendon" rapidly developed from young fibroblastic tissue outgrowths of the loose mesenchymal tissue of the perineurium and adventitia of the blood vessels in the adjacent neurovascular bundle. Silk or nylon replacement of the excised Achilles tendon did not lead to successful production of a new substitute. Carbon fibers were unsatisfactory for replacement implants for the flexor digitorum longus tendons.
mesh_terms: D000125:Achilles Tendon / Q000098:blood supply / Q000601:surgery; D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D002244:Carbon / Q000627:therapeutic use*; D005260:Female; D008297:Male; D011474:Prosthesis Design / Q000592:standards*; D011817:Rabbits; D013710:Tendons / Q000601:surgery*; D014945:Wound Healing
chemical_list: D001672:Biocompatible Materials; D002244:Carbon