Tumour production of alkaline phosphatase in a patient with giant-cell carcinoma of bronchus.
A patient with a giant-cell carcinoma of the bronchus was found to have a raised serum alkaline phosphatase without any evidence of bone or liver involvement. After necropsy the excised tumour was found to be producing alkaline phosphatase. The alkaline phosphatase found in the serum during life was heat-labile but that in the tumour was heat-stable. The significance of this is unknown.
D000469:Alkaline Phosphatase / Q000096:biosynthesis* / Q000097:blood; D001984:Bronchial Neoplasms / Q000201:enzymology* / Q000473:pathology; D002277:Carcinoma / Q000201:enzymology* / Q000473:pathology; D006651:Histocytochemistry; D006358:Hot Temperature; D006801:Humans; D008297:Male; D008875:Middle Aged
D000469:Alkaline Phosphatase