title: Effect of somatostatin on basal and stimulated pancreatic secretion in the rat.
abstract: The effect of linear somatostatin on pancreatic exocrine secretion in anaesthetized rats has been studied. Basal secretion of amylase was significantly inhibited by an infusion of 100 microgram/100 g/h somatostatin, but increased fourfold after a bolus injection of 50 microgram/100 g. CCK-stimulated enzyme and volume secretion were inhibited by somatostatin. Somatostatin did not influence secretin-stimulated bicarbonate concentration or rate of secretion in the dose range in which enzyme secretion was inhibited.
mesh_terms: D000681:Amylases / Q000378:metabolism; D000818:Animals; D001639:Bicarbonates / Q000378:metabolism; D002766:Cholecystokinin / Q000494:pharmacology; D008297:Male; D010189:Pancreatic Juice / Q000032:analysis / Q000378:metabolism*; D051381:Rats; D012633:Secretin / Q000494:pharmacology; D012636:Secretory Rate / Q000187:drug effects; D013004:Somatostatin / Q000494:pharmacology*; D013268:Stimulation, Chemical
chemical_list: D001639:Bicarbonates; D012633:Secretin; D013004:Somatostatin; D002766:Cholecystokinin; D000681:Amylases