Is attenuation of tRNA charging responsible for the inhibition of protein labelling accompanying depolarisation of the cerebral cortical cells?
Topical application of concentrated solutions of KCl resulted in reduction of charging of tRNA 7 min after s.c. injection of L-(U-14C) leucine. Neither radioactivity nor pool size of the total amino acids changed during this period.
D000818:Animals; D002250:Carbon Radioisotopes; D002540:Cerebral Cortex / Q000378:metabolism*; D007553:Isotope Labeling; D007930:Leucine / Q000378:metabolism; D008297:Male; D011189:Potassium Chloride / Q000494:pharmacology; D011506:Proteins / Q000378:metabolism; D012343:RNA, Transfer / Q000502:physiology*; D051381:Rats
D002250:Carbon Radioisotopes; D011506:Proteins; D011189:Potassium Chloride; D012343:RNA, Transfer; D007930:Leucine