title: [Action of barbituric acid derivatives on the physiocochemical properties of DNA].
abstract: The action of barbituric acid derivatives--phenobarbital, sodium ethaminal and sodium amytal--on the physico-chemical properties of mucleic acids was studied. It is shown that as compared to sodium ethaminal and sodium amytal phenobarbital exerts a more potent action on the secondary and tertiary structure of native DNA molecules.
mesh_terms: D000654:Amobarbital / Q000494:pharmacology; D000818:Animals; D001463:Barbiturates / Q000494:pharmacology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004247:DNA / Q000494:pharmacology*; D004347:Drug Interactions; D066298:In Vitro Techniques; D010424:Pentobarbital / Q000494:pharmacology; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D013056:Spectrophotometry, Ultraviolet
chemical_list: D001463:Barbiturates; D004247:DNA; D000654:Amobarbital; D010424:Pentobarbital; D010634:Phenobarbital
vernacular_title: Izuchenie deĭstviia proizvodnykh barbiturovoĭ kisloty na fiziko-khimicheskie svoĭstva DNK.