Synthesis of 4,5-dimethoxykynuramine and its in vivo conversion to 6,7-dimethoxy-4-quinolinol.
4,5-Dimethoxykynuramine was synthesized in a three-step sequence originating with veratrole. Indirect evidence indicates that the drug was converted in vivo to the hypotensive agent 6,7-dimethoxy-4-quinolinol by the action of monoamine oxidase.
D000818:Animals; D006912:Hydroxyquinolines / Q000378:metabolism*; D007735:Kynuramine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000378:metabolism; D008297:Male; D011427:Propiophenones / Q000138:chemical synthesis*; D051381:Rats
D006912:Hydroxyquinolines; D011427:Propiophenones; D007735:Kynuramine