[Mechanism of action of lithium salts on the ethanol predilection by rats].
Lithium chloride with its intraperitoneal administration to rats in a dose of 35 mg/kg, twice a day for 14 days, is shown to suppress predelection for ethanol formed by a 2-month consumption of its 5% solution. This effect of the lithium salt correlates with normalization of the activity displayed by central biorhythms regulators--neurosecretory hypothalamus, nuclei, earlier disorganized by ethanol. A possible relation between the ability of the lithium salts to normalize the central regulation of the biorhythms and their high therapeutic effectiveness in dealing with affective disturbances with a periodic course is discussed.
D000428:Alcohol Drinking; D000818:Animals; D001683:Biological Clocks / Q000187:drug effects; D003864:Depression, Chemical; D007031:Hypothalamus / Q000187:drug effects; D008094:Lithium / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D009490:Neurosecretory Systems / Q000187:drug effects; D051381:Rats; D013997:Time Factors
D008094:Lithium
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