The effects of cannabinoids on body temperature and brain catecholamine synthesis.
delta9-Tetrahydrocannabinol, 11-OH-delta9-tetrahydrocannabinol and 9-nor-9beta-OH-hexahydrocannabinol produced hypothermia and increased catecholamine synthesis in mouse brain. The potencies of the effects of these compounds were correlated. Cannabinol and cannabidiol were inactive in both tests.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002186:Cannabinoids / Q000494:pharmacology*; D002395:Catecholamines / Q000096:biosynthesis*; D004298:Dopamine / Q000096:biosynthesis; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009638:Norepinephrine / Q000096:biosynthesis
D002186:Cannabinoids; D002395:Catecholamines; D004298:Dopamine; D009638:Norepinephrine