Morphological effects of estrogen on the female rat liver nucleolus.
Prolonged administration of nonphysiological amounts of estrogen induced markedly enlarged nucleoli volumes in rat hepatocytes, indicative of increased nucleolar RNA synthesis. Physiological amounts of drug had no apparent morphological effects on the hepatocytes.
D000818:Animals; D002466:Cell Nucleolus / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure*; D008656:Mestranol / Q000494:pharmacology; D012313:RNA / Q000096:biosynthesis; D051381:Rats
D004967:Estrogens; D012313:RNA; D008656:Mestranol