title: [Cimetidine in the treatment of duodenal ulcer (author's transl)].
abstract: In a double-blind trial of patients with duodenal ulcer at three centres the healing rate after a four-week course of treatment (1 g cimetidine daily) was 79% (30 out of 38 patients), compared with 58% (23 out of 40 patients) on placebos. Cimetidine did not effect subjective symptoms or the need for antacids to relieve pain, except for a minor beneficial effect on diurnal ulcer symptoms during the second week of treatment. Results of long-term administration suggest that cimetidine at 400 mg daily prevent s relapses, but the possibility of an increased relapse rate after cimetidine withdrawal can not as yet be excluded.
mesh_terms: D000328:Adult; D000368:Aged; D000553:Ambulatory Care; D002927:Cimetidine / Q000008:administration & dosage / Q000627:therapeutic use*; D004311:Double-Blind Method; D004381:Duodenal Ulcer / Q000188:drug therapy*; D005260:Female; D006146:Guanidines / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010919:Placebos; D012008:Recurrence
chemical_list: D006146:Guanidines; D010919:Placebos; D002927:Cimetidine
vernacular_title: Cimetidin in der Behandlung des Ulcus duodeni. Ergebnisse einer Doppelblindstudie bei ambulant behandelten Patienten.