title: [Macrocytic anaemia with folic acid deficiency in hypothyroidism (author's transl)].
abstract: Three different kinds of anaemia are seen in hypothyroidism: (1) normocytic, normochromic anaemia; (2) microcytic, hypochromic anaemia; (3) macrocytic normochromic anaemia. The latter is either a true pernicious anemia, which occurs fairly frequently in Hashimoto's thyroiditis, or maturation disorder of erythropoiesis as a result of folic acid deficiency. In three patients with primary hypothyroidism and macrocytic anaemia there were decreased levels of serum folic acid. After short-term administration of folic acid and 1-year of thyroxine the blood picture became normal in two of the patients.
mesh_terms: D000328:Adult; D000368:Aged; D000748:Anemia, Macrocytic / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D005492:Folic Acid / Q000627:therapeutic use; D005494:Folic Acid Deficiency / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D007037:Hypothyroidism / Q000150:complications* / Q000188:drug therapy / Q000209:etiology; D008297:Male; D008875:Middle Aged; D013965:Thyroidectomy / Q000009:adverse effects; D013974:Thyroxine / Q000627:therapeutic use
chemical_list: D005492:Folic Acid; D013974:Thyroxine
vernacular_title: Makrozytäre Anämie mit Folsäuremangel bei Hypothyreose.