Sequential pure red cell and megakaryocyte aplasia associated with chronic liver disease and ulcerative colitis.
The clinical course of a patient with chronic hepatitis and previous ulcerative colitis who subsequently developed pure red cell aplasia (PRCA) is described. The PRCA remitted initially with corticosteroid therapy. A subsequent relapse responded to cyclophosphamide therapy following splenectomy. This was followed by a fatal third episode of red cell aplasia associated with megakaryocyte aplasia.
D000293:Adolescent; D000741:Anemia, Aplastic / Q000150:complications* / Q000188:drug therapy; D001379:Azathioprine / Q000627:therapeutic use; D002908:Chronic Disease; D003093:Colitis, Ulcerative / Q000150:complications*; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006505:Hepatitis / Q000150:complications*; D006801:Humans; D011239:Prednisolone / Q000627:therapeutic use
D003520:Cyclophosphamide; D011239:Prednisolone; D001379:Azathioprine