In vitro activity of sisomicin and netilmicin alone and in combination with nafcillin, oxacillin and methicillin against enterococci.
The in vitro activity of sisomicin and netilmicin alone and in combination with nafcillin, oxacillin and methicillin against 30 strains of enterococci was investigated. Sisomicin and netilmicin alone were not very effective against enterococci. There was enhanced killing of some strains of enterococci by the combination of sisomicin or netilmicin with one of the three penicillinase-resistant penicillins. Nafcillin was the most effective penicillinase-resistant penicillin in the combination. Sisomicin appeared to be slightly more effective than netilmicin in combination with one of the penicillinase-resistant penicillins against enterococci.
D004357:Drug Synergism; D005839:Gentamicins / Q000494:pharmacology*; D007422:Intestines / Q000382:microbiology; D008712:Methicillin / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009254:Nafcillin / Q000494:pharmacology*; D010068:Oxacillin / Q000494:pharmacology*; D012853:Sisomicin / Q000031:analogs & derivatives / Q000494:pharmacology*; D013291:Streptococcus / Q000187:drug effects*
D005839:Gentamicins; D009254:Nafcillin; D008712:Methicillin; D010068:Oxacillin; D012853:Sisomicin