Synthesis and antiarrhythmic activity of 2-dialkylaminoalkyl-9-phenyl-1H-indeno[2,1-c]pyridine derivatives.
Some dihydro- and hexahydro-2-dialkylaminoalkyl-9-phenyl-1H-indeno[2,1-c]pyridines were prepared and found to possess significant antiarrhythmic activity. Hydrogenation of the dihydro compounds 4 produced the allcis-hexahydro isomers 5 which were consistently active in three assays against induced ventricular arrhythmias. On the other hand, the H9H9a-trans isomers, which were obtained by basic equilibration of the cis isomers, were less effective.
D000157:Aconitine; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis*; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000503:physiopathology; D003331:Coronary Vessels / Q000502:physiology; D004285:Dogs; D005260:Female; D066298:In Vitro Techniques; D007192:Indenes / Q000138:chemical synthesis / Q000494:pharmacology; D008026:Ligation; D008297:Male; D010042:Ouabain; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D011817:Rabbits; D013329:Structure-Activity Relationship
D000889:Anti-Arrhythmia Agents; D007192:Indenes; D011725:Pyridines; D010042:Ouabain; D000157:Aconitine