Plasma potassium in hypertensive Africans on frusemide.
The effects of potassium chloride (as Slow-K 600 mg three times daily) and spironolactone (as Aldactone A 25 mg four times daily) were compared in hypertensive African patients on frusemide. Mean plasma-potassium levels in patients on frusemide plus Slow-K and frusemide plus Aldactone-A rose from 3.6 to 3.8 mOsm/L whilst on frusemide alone mean plasma-potassium fell from 3.7 to 3.6 mOsm/L. The mean blood pressure, both systolic and diastolic, was significantly reduced in the frusemide plus Aldactone-A group when compared with patients on frusemide alone or on frusemide plus Slow-K.
D000328:Adult; D000368:Aged; D004359:Drug Therapy, Combination; D005260:Female; D005665:Furosemide / Q000009:adverse effects*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007008:Hypokalemia / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D011189:Potassium Chloride / Q000627:therapeutic use*; D013148:Spironolactone / Q000627:therapeutic use*
D013148:Spironolactone; D011189:Potassium Chloride; D005665:Furosemide