title: Why do nucleic acids have 3'5' phosphodiester bonds?
abstract: Details of the stereochemistry of the 2'5' and 3'5' dinucleoside monophosphates of polynucleotides have been delineated in aqueous solution using nuclear magnetic resonance spectroscopy. Incorporation of these experimentally determined geometries into the structure of polynucleotides reveals that the intrinsic spatial configurations of the 2'5' bonds cannot support helical structures whereas the geometries of 3'5' bonds allow the formation of helical configurations for RNA.
mesh_terms: D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D009690:Nucleic Acid Conformation; D009843:Oligoribonucleotides; D009943:Organophosphorus Compounds; D011131:Polyribonucleotides; D012267:Ribosemonophosphates; D013329:Structure-Activity Relationship
chemical_list: D009843:Oligoribonucleotides; D009943:Organophosphorus Compounds; D011131:Polyribonucleotides; D012267:Ribosemonophosphates