title: Protein binding of drugs.
abstract: Basic considerations involved in the interaction of drugs with proteins are reviewed. The important role of the concentration of unbound drug in determining therapeutic and toxicologic effects is emphasized. Ultra-filtration is suggested to be the method of choice for the determination of concentrations of unbound drug in plasma in clinical practice.
mesh_terms: D001665:Binding Sites; D001692:Biological Transport; D001798:Blood Proteins / Q000378:metabolism*; D005110:Extracellular Space / Q000378:metabolism; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000097:blood / Q000378:metabolism*; D011485:Protein Binding; D014116:Toxicology; D014462:Ultrafiltration
chemical_list: D001798:Blood Proteins; D004364:Pharmaceutical Preparations