Variably occlusive tape systems and the mitotic activity of stripped human epidermis. Effects with and without hydrocortisone.
This study elaborates on the effect of occlusive, partially occlusive, and nonocclusive tape systems containing hydrocoritsone on human epidermal mitotic activity that has been increased by tape stripping. The experimental variables included tape delivery systems affording total, partial (50%), or no occlusion to normal human skin. The test corticosteroid was hydrocortisone at a dose range of 1, 4, and 20 microgram/sq cm. Utilizing demecolcine cream, biopsy specimens, were taken and mitotic figures determined. Results suggest that potent antimitotic effects occur equally with semiocclusive and nonocclusive tapes containing hydrocortisone as with total occlusive tapes. Verification of the practicality of this in clinical use will depend on appropriate clinical trials in diseased states.
D002482:Cellulose; D003703:Demecolcine / Q000494:pharmacology; D005030:Ethylenes; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology*; D008297:Male; D008938:Mitosis / Q000187:drug effects*; D009779:Occlusive Dressings; D011095:Polyethylenes; D012867:Skin / Q000187:drug effects*; D014753:Vinyl Compounds
D005030:Ethylenes; D011095:Polyethylenes; D014753:Vinyl Compounds; D002482:Cellulose; D006854:Hydrocortisone; D003703:Demecolcine