title: Transmissible murine colonic hyperplasia.
abstract: After exposure to a variant of Citrobacter freundii, suckling and adult mice developed transmissible murine colonic hyperplasia of the same degree of severity. Mucosal hyperplasia was most severe 2 to 3 weeks after inoculation and then regressed. Suckling mice had a high mortality because of secondary inflammatory and erosive changes. Severe hyperplasia was characterized by mitotic activity along the entire crypt column and surface mucosa.
mesh_terms: D000818:Animals; D002954:Citrobacter; D003092:Colitis / Q000473:pathology / Q000662:veterinary; D003106:Colon / Q000473:pathology; D003108:Colonic Diseases / Q000473:pathology / Q000662:veterinary*; D004756:Enterobacteriaceae Infections / Q000473:pathology / Q000662:veterinary*; D005260:Female; D006965:Hyperplasia; D007413:Intestinal Mucosa / Q000473:pathology; D008297:Male; D051379:Mice; D012376:Rodent Diseases / Q000473:pathology*