title: Surgical treatment of myelomatosis--a review of 18 cases.
abstract: The authors review 18 patients with multiple myeloma who had bone destruction of a kind that indicated surgical therapy. Eight patients had paralegic myelopathy and one had compression of the cauda equina. Four of them displayed partial to complete regression. One patient lived for 77 months after the operation, most of the time in excellent condition. The operative technique is discussed, with laminectomy, exeresis, filling of bone with cement and, in some instances, mechanical support from metal plates. Early diagnosis and operation is imperative, postoperative irradiation obligatory in severe cases. Radiation alone may be the method of choice in early stages. The other 9 patients were operated upon for bone destruction in the limbs. A Moore operation on the destroyed hip was performed in one patient, who lived in excellent condition for about four years. Active surgical therapy combined with radiation and cytostatics seems to be of value in many patients with multiple myeloma.
mesh_terms: D000368:Aged; D001178:Arthroplasty; D001859:Bone Neoplasms / Q000150:complications / Q000601:surgery*; D005260:Female; D005264:Femoral Fractures / Q000209:etiology; D005266:Femoral Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery; D005593:Fracture Fixation, Internal; D006801:Humans; D007796:Laminectomy; D008297:Male; D008722:Methods; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery*; D009362:Neoplasm Metastasis; D011859:Radiography