Termination of tolerance to HSA in chickens.
A major part of chickens made tolerant to HSA at hatching formed anti-HSA antibodies when immunized with cross-reacting antigen, the BSA, at 4 weeks of age, although tolerant birds immunized with HSA produced no detectable antibody levels. Immunization with HSA + BSA did not prevent anti-HSA antibody formation in tolerant chickens, but it seems that the escape from tolerance is more rapid in birds immunized with BSA only than in those immunized with HSA + BSA and/or HSA only.
D000818:Animals; D000917:Antibody Formation; D002645:Chickens / Q000276:immunology; D003429:Cross Reactions; D007108:Immune Tolerance; D007114:Immunization; D008214:Lymphocytes / Q000276:immunology; D012709:Serum Albumin / Q000276:immunology*; D012710:Serum Albumin, Bovine / Q000276:immunology*
D012709:Serum Albumin; D012710:Serum Albumin, Bovine