[Action of molsidomine on haemodynamics at rest and on exercise in patients who have coronary heart disease (author's transl)].
In ten patients with coronary heart disease molsidomine achieved a clear-cut decrease in pre- and after-load of the heart at rest. Due to decreased venous return at rest there was a fall in stroke volume resulting in a fall of systolic and diastolic aortic pressure. But at the same level of standardised exercise, systolic and diastolic arterial pressure and cardiac output were similar with or without molsidomine. Without changing after-load, there was a fall in pulmonary artery mean pressure (P less than 0.005), probably due to an increase in left-ventricular compliance and (or) a fall in pulmonary vascular resistance. A rise in venous capacity or a decrease in venous return during exercise was excluded as a possible mechanism of molsidomine action.
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D003327:Coronary Disease / Q000188:drug therapy*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009025:Morpholines / Q000627:therapeutic use*; D010069:Oxadiazoles / Q000627:therapeutic use*; D005082:Physical Exertion; D011651:Pulmonary Artery; D011652:Pulmonary Circulation / Q000187:drug effects; D013558:Sydnones / Q000627:therapeutic use*; D014655:Vascular Resistance / Q000187:drug effects
D009025:Morpholines; D010069:Oxadiazoles; D013558:Sydnones
Wirkung von Molsidomin auf die Hämodynamik in Ruhe und unter Belastung bei Patienten mit koronarer Herzkrankheit.