[Comparison of the morphological changes in the capillaries and the state of the renin-angiotensin-aldosterone system in diabetes mellitus].
Microangiopathies were the earliest and most frequent complications of diabetes mellitus; however, their pathogenetic mechanisms are still obscure. Electron microscopic study of the capillaries of the gastrocnemius was conducted in 11 patients with diabetes mellitus at the state of decompensation and in 8--of clinical compensation; blood aldosterone level and the plasma renin activity were determined by the radio-immunological method. A marked thickening of the capillary basal membrane (the most marked sign of microvascular affection) was revealed in all the patients under study; there was also an increase in the aldosterone level and renin activity. The mentioned changes were to the greatest degree (statistically significant values) expressed in the patients at the state of decompensation. Analysis of the data obtained revealed a direct correlative relationship of these changes.
D000328:Adult; D000450:Aldosterone / Q000097:blood*; D000804:Angiotensin II / Q000097:blood*; D001485:Basement Membrane / Q000648:ultrastructure; D002196:Capillaries / Q000648:ultrastructure*; D003925:Diabetic Angiopathies / Q000503:physiopathology*; D006801:Humans; D007718:Knee Injuries / Q000503:physiopathology; D007869:Leg Injuries / Q000503:physiopathology; D008875:Middle Aged; D012083:Renin / Q000097:blood*
D000804:Angiotensin II; D000450:Aldosterone; D012083:Renin
Sopostavlenie morfologicheskikh izmeneniĭ kapilliarov i sostoianiia sistemy renin-angiotenzin-al'dosteron u bol'nykh sakharnym diabetom.