[Concentrations of Bupivacaine in the CSF following subdural application (author's transl)].
The subarachnoid concentration of isobaric bupivacaine following intrathecal injection was determined in 11 patients by periodic sampling. After injection of 15 mg/ml of bupivacaine, the maximal concentration in CSF averaged 284 microgram/ml. The decline was exponential after 240 min a residual concentration of 7 microgram/ml was determined. The area of sensory block was maximal after 20 min regression began from cranial at 90 min, from caudal at 150 min. Bupivacain could not be determined in blood.
D000328:Adult; D000368:Aged; D002045:Bupivacaine / Q000134:cerebrospinal fluid*; D006801:Humans; D008875:Middle Aged; D013355:Subdural Space; D013997:Time Factors
D002045:Bupivacaine
Liquorkonzentration von Bupivacain nach subduraler Applikation.