The influence of the type of sulphate bond and degree of sulphation of glycosaminoglycans on their interaction with lysosomal enzymes.
Significant differences occur between the interaction of several sulphated glycosaminoglycans with a particular lysosomal protein, leading to inhibition in the case of lysosomal enzymes. The order of strength of inhibition at pH4 was: heparin greater than chondroitin 4-sulphate = chondroitin 6-sulphate greater than dermatan sulphate.
D004791:Enzyme Inhibitors; D006025:Glycosaminoglycans / Q000494:pharmacology*; D008247:Lysosomes / Q000201:enzymology*; D013431:Sulfates
D004791:Enzyme Inhibitors; D006025:Glycosaminoglycans; D013431:Sulfates