Embryonic implantation, dietary intake, and plasma GH concentration in pregnant mice exposed to hypoxia.
Inseminated mice were: 1) exposed to 8% O2, 2) pair fed to mice exposed to 8% O2, 3) fasted at 21% O2 or 4) maintained at 21% O2 (control) between Days 1-3 of pregnancy. The frequency of embryonic implantation sites in mice was reduced by greater than 60% in 8% O2 exposed and pair fed animals, and by 100% in fasted mice. During the initial 24 h of exposure to 8% O2, a significant component of the body weight lost by hypoxic mice was associated with the reduction in dietary intake. The contragestational effects of hypoxia and fasting were attributed to the endocrine consequences of inanition induced by hypophagia and adypsia. Plasma samples collected at 6-h intervals revealed a significant reduction in GH concentration in treatment groups compared to the controls.
D000818:Animals; D001835:Body Weight; D004435:Eating; D010064:Embryo Implantation; D005260:Female; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D000860:Hypoxia / Q000097:blood / Q000503:physiopathology; D051379:Mice; D009929:Organ Size; D010053:Ovary / Q000503:physiopathology; D011247:Pregnancy; D011270:Pregnancy, Animal; D014599:Uterus / Q000503:physiopathology
D013006:Growth Hormone