Transitory renal failure following rapid administration of a relatively large amount of hematin in a patient with acute intermittent porphyria in clinical remission.
Transitory renal failure occurred in a patient with acute intermittent porphyria in clinical remission following i.v. administration of 1 000 mg hematin. The clinical and biochemical picture suggested "acute tubular necrosis", which was followed by a prompt and complete return of renal function without any late sequelae. The renal failure is thought to have resulted from the presence of circulating free hematin, formed as a result of rapid administration of such a relatively large amount. Such a complication has not occurred in patients given hematin for acute porphyric relapse, in whom much smaller amounts have been infused.
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000328:Adult; D006418:Heme / Q000031:analogs & derivatives*; D006427:Hemin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007263:Infusions, Parenteral; D007684:Kidney Tubules / Q000187:drug effects / Q000473:pathology; D008297:Male; D009336:Necrosis; D011164:Porphyrias / Q000188:drug therapy*; D012075:Remission, Spontaneous
D006418:Heme; D006427:Hemin