Effects of propylbenzilylcholine mustard on injection into the liquor space of cats.
In unanaesthetized cats the effects were examined of propylbenzilylcholine mustard (PrBCM) on injection into the cannulated cerebral ventricles and cisterna magna. Extreme motor excitation, vocalization, shivering leading to fever, tachypnoea, panting, piloerection and salivation were produced on ventricular, vigorous scratching bouts on cisternal, injections. The sites of these actions are discussed. None of the effects was produced by atropine similarly injected. All effects were suppressed by anaesthetizing doses of pentobarbitone sodium injected intraperitoneally.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D002415:Cats; D002552:Cerebral Ventricles / Q000187:drug effects*; D002794:Choline / Q000031:analogs & derivatives*; D002946:Cisterna Magna / Q000187:drug effects*; D005260:Female; D007276:Injections, Intraventricular; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology; D011438:Propylbenzilylcholine Mustard / Q000037:antagonists & inhibitors / Q000494:pharmacology*
D011438:Propylbenzilylcholine Mustard; D001285:Atropine; D010424:Pentobarbital; D002794:Choline