[Role of the adrenal glands in the cytostatic action mechanism of antitumor antibiotics].
The state of the steroidogenic function of the adrenal glands, lipid spectrum of the adrenal gland tissue and metabolism rate of 11-oxycorticosteroids (11-OCS) in the liver tissue and their levels in the blood plasma were studied on rats after a single administration of karminomycin in a dose of LD50 (1.55 mg/kg). The hormones of the adrenal cortex were shown to play a definite role in the mechanism of the karminomycin damaging effect. Dependence of the changes on the time of the drug effect was noted. The shifts were of a reversible character. No direct toxic damages in the tissue of the adrenal glands were observed. Only an increase in the 11-OCS blood levels and a decrease in the steroid metabolism in the liver tissue were shown. The latter must be due to the direct cytotoxic effect of karminomycin on the tissue of this organ.
D015062:11-Hydroxycorticosteroids / Q000096:biosynthesis / Q000097:blood; D000311:Adrenal Glands / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D002360:Carubicin / Q000494:pharmacology; D005609:Free Radicals; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism; D051381:Rats; D013997:Time Factors
D015062:11-Hydroxycorticosteroids; D000903:Antibiotics, Antineoplastic; D005609:Free Radicals; D002360:Carubicin
O roli nadpochechnikov zhelez v mekhanizme tsitostaticheskogo deĭstviia protivoopukholevykh antibiotikov.