Tolmesoxide, a drug that lowers blood pressure by a direct relaxant effect on vascular smooth muscle.
1 The blood pressure of conscious, deoxycorticosterone acetate (DOCA) hypertensive and 1 kidney Goldblatt hypertensive rats and renal hypertensive and normotensive cats was reduced by tolmesoxide (4,5-dimethoxy-o-tolyl methyl sulphoxide). 2 Tachycardia accompanied the hypotension. In rats the increase in heart rate was abolished by concurrent administration of propranolol. Tachycardia did not occur in pithed rats. 3 Vascoconstriction induced by sympathetic stimulation, noradrenaline, tyramine, angiotensin or vasporessin was antagonized by tolmesoxide. 4 The antagonism of vasoconstrictor responses produced by tolmesoxide was unaffected by beta-adrenoceptor, muscarinic or histamine antagonists. 5 It is concluded that the lowering of pressure produced by tolmesoxide results from a defect relaxant effect on vascular smooth muscle.
D000818:Animals; D000959:Antihypertensive Agents; D001794:Blood Pressure / Q000187:drug effects*; D002415:Cats; D004231:Diuresis / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate / Q000187:drug effects; D006973:Hypertension / Q000188:drug therapy; D008297:Male; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D013454:Sulfoxides / Q000037:antagonists & inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D014050:Toluene / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D014665:Vasodilator Agents
D000959:Antihypertensive Agents; D013454:Sulfoxides; D014665:Vasodilator Agents; D014050:Toluene; D011433:Propranolol; C016152:tolmesoxide