Antagonism by morphine and pethidine of the contractile effects of PGE2 on isolated uterus of the rat.
Morphine antagonizes the twitches evoked by administration of PGE2 on spontaneous contractile activity in the isolated uterus of the rat. This action is dose-dependent. Concentrations as low as 2.6 nM completely abolished contractile activity of PGE2 added to the bath at a concentration of 0.5 ng ml-1. In contrast to morphine, pethidine partially antagonized the stimulatory action of PGE2 at much higher concentrations.
D000818:Animals; D005260:Female; D066298:In Vitro Techniques; D008614:Meperidine / Q000494:pharmacology*; D009020:Morphine / Q000494:pharmacology*; D011458:Prostaglandins E / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D051381:Rats; D014590:Uterine Contraction / Q000187:drug effects*
D011458:Prostaglandins E; D009020:Morphine; D008614:Meperidine