Inhibition of testicular androgenesis by urinary gonadotropin-inhibiting substances in rats.
The effect of urinary gonadotropin-inhibiting substances (GIS) on the androgen synthesis in rat testes was studied in vitro and in vivo. GIS, which was added to the incubation medium containing tesased testicular tissues and injected into rats for 2 days, showed a suppressive effect on the formation of androstenedione from pregnenolone in the testis.
D000728:Androgens / Q000096:biosynthesis*; D000735:Androstenedione / Q000096:biosynthesis; D000818:Animals; D006062:Gonadotropins / Q000037:antagonists & inhibitors*; D008297:Male; D008550:Melatonin / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology / Q000652:urine*; D051381:Rats; D013737:Testis / Q000187:drug effects / Q000378:metabolism*; D013739:Testosterone / Q000096:biosynthesis
D000728:Androgens; D006062:Gonadotropins; D010455:Peptides; D013739:Testosterone; D000735:Androstenedione; D008550:Melatonin