Fungal toxicity of phosfon D and its reversion by lipids.
The growth retardant Phosfon D inhibits the growth of some yeasts and human pathogenic filamentous fungi. The toxic effects of the compound on the dermatophyte Microsporum cookei were completely reversed by adding ergosterol and oleic acid to the medium. The significance of these findings is discussed.
D004875:Ergosterol / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects* / Q000254:growth & development; D008055:Lipids / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009829:Oleic Acids / Q000494:pharmacology; D009861:Onium Compounds / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D009943:Organophosphorus Compounds / Q000037:antagonists & inhibitors / Q000494:pharmacology*
D008055:Lipids; D009829:Oleic Acids; D009861:Onium Compounds; D009943:Organophosphorus Compounds; C008887:phosphon; D004875:Ergosterol