[Heparin clearance during activation of the anticoagulation system in animals].
Retarded heparin-35S clearance from the blood stream during activation of the blood anticoagulation system was observed. Under these conditions the half-life of heparin-35S increased from 1.6 h in control animals to 2.35 h in the animals after intravenous injection of a threshold dose of thrombin causing activation of the anticoagulation system. Retarded heparin-35S clearance from the blood stream during activation of the blood anticoagulation system is accompanied by increase of its absorption in the liver and in the auricular atrii.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D006493:Heparin / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D008657:Metabolic Clearance Rate; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D013154:Spleen / Q000378:metabolism; D013917:Thrombin / Q000494:pharmacology; D013997:Time Factors
D006493:Heparin; D013917:Thrombin
Klirens geparina v usloviiakh vozbuzhdeniia protivosvertyvaiushcheĭ sistemy zhivotnykh.