[Effect of iprazid on serotonin inactivation by lung tissue].
Tests on isolated perfused lungs of albino rats were conducted to study the effect of iprazide (5.10(4) M) on inactivation of serotonin (5-OT) by the pulmonary tissue. Iprazide does not noticeably inhibit the inactivation of 5-OT, but it greatly reduces the activity of pulmonary monoaminoxidase, the consequence of which is accumulation of appreciable amount of 5-OT in the lungs. The 5-OT protected against destruction amasses in the cytoplasm and is not bound with cellular organoids.
D000042:Absorption; D000818:Animals; D003864:Depression, Chemical; D004789:Enzyme Activation / Q000187:drug effects; D066298:In Vitro Techniques; D007490:Iproniazid / Q000494:pharmacology*; D008168:Lung / Q000187:drug effects* / Q000378:metabolism; D008996:Monoamine Oxidase Inhibitors; D051381:Rats; D012701:Serotonin / Q000378:metabolism*
D008996:Monoamine Oxidase Inhibitors; D012701:Serotonin; D007490:Iproniazid
Vliianie iprazida na inaktivatsiiu serotonina legochnoĭ tkan'iu.