Effect of oxygen pressure during culture on survival of mouse thyroid allografts.
A marked increase in the percentage of mouse thyroids that retained function 20 days after transplantation across a major histocompatibility barrier and the percentage that lacked generalized infiltration was observed when the grafts received hyperbaric oxygen during a 4-day culture period. Perfusion of the donor animal before thyroidotomy and the addition of fetal calf serum to the culture medium did not have a significant effect on graft survival, but the percentage of grafts lacking generalized infiltration was slightly increased by the addition of hydrocortisone to the culture medium.
D000818:Animals; D001769:Blood; D003470:Culture Media; D006085:Graft Survival / Q000187:drug effects; D006854:Hydrocortisone / Q000494:pharmacology; D006931:Hyperbaric Oxygenation; D051379:Mice; D009924:Organ Culture Techniques / Q000379:methods*; D013961:Thyroid Gland / Q000637:transplantation*; D014184:Transplantation, Homologous
D003470:Culture Media; D006854:Hydrocortisone