Tumor promoters inhibit morphological differentiation in cultured mouse neuroblastoma cells.
When added to mouse neuroblastoma cultures, the potent tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA) inhibits spontaneous neurite formation as well as that induced in response to serum deprivation, prostaglandin E1, 5-bromo-2'-deoxyuridine, and papaverine. Other tumor-promoting macrocyclic plant diterpenes also inhibit neurite formation, whereas nonpromoting diterpenes do not. Inhibition by TPA was reversible and was unrelated to toxicity.
D001973:Bromodeoxyuridine / Q000037:antagonists & inhibitors; D002454:Cell Differentiation / Q000187:drug effects; D002460:Cell Line; D004224:Diterpenes / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D009447:Neuroblastoma / Q000473:pathology; D009474:Neurons / Q000166:cytology*; D010208:Papaverine / Q000037:antagonists & inhibitors; D010704:Phorbols / Q000494:pharmacology*; D011458:Prostaglandins E / Q000037:antagonists & inhibitors; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*
D004224:Diterpenes; D010704:Phorbols; D011458:Prostaglandins E; D010208:Papaverine; D001973:Bromodeoxyuridine; D013755:Tetradecanoylphorbol Acetate