Extensive metastases in Peutz-Jeghers syndrome.
A 27-year-old woman with Peutz-Jeghers syndrome since age 11 years was hospitalized with a sudden onset of weakness of the right extremity, an expressive aphasia, and a three-month history of back pain. Liver and whole-body scintigrams demonstrated multiple metastatic disease; the brain scintigraphic study was compatible with infarction of the left hemisphere. Postmoretem examination two weeks after these studies showed extensive metastases in bone, liver, brain, lung, and left ovary. The source of the metastases was a malignant change from Peutz-Jeghers polyps.
D000230:Adenocarcinoma / Q000473:pathology; D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000473:pathology; D001921:Brain / Q000098:blood supply; D001932:Brain Neoplasms / Q000473:pathology; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007238:Infarction / Q000473:pathology; D008113:Liver Neoplasms / Q000473:pathology; D008175:Lung Neoplasms / Q000473:pathology; D009362:Neoplasm Metastasis; D010051:Ovarian Neoplasms / Q000473:pathology; D010580:Peutz-Jeghers Syndrome / Q000000981:diagnostic imaging / Q000473:pathology*; D011877:Radionuclide Imaging