title: Effect of cimetidine, histamine H2 receptor antagonist, in the prevention of experimental stress ulcer in the rat.
abstract: The protective effect of cimetidine on gastric mucosal lesions in the rat was investigated. Through prophylactic administration of 3x 25 7g/kh body weight for 24 just prior to the test period, the incidence rate of lesions, as well as upper gastro-intestinal haemorrhage was highly significantly reduced.
mesh_terms: D000818:Animals; D002927:Cimetidine / Q000627:therapeutic use*; D005753:Gastric Mucosa / Q000187:drug effects; D006146:Guanidines / Q000627:therapeutic use*; D008297:Male; D010438:Peptic Ulcer Hemorrhage / Q000517:prevention & control; D051381:Rats; D013276:Stomach Ulcer / Q000209:etiology / Q000517:prevention & control*; D013312:Stress, Physiological
chemical_list: D006146:Guanidines; D002927:Cimetidine