Evidence for a physiological role of prostaglandins in oviposition by the hen.
A single oral dose of indomethacin (25 mg) given 2--4 h before expected oviposition delayed oviposition by about 12 h and suppressed plasma PGE levels by about 90%. Intrauterine injection of PGE-1 (0.2--0.4 microgram/hen) to 12 hens pretreated with 25 mg indomethacin induced oviposition in all birds in about 7 1/2 min. Passive immunization with goat antiserum to PGE-1 delayed oviposition (69%) in 4 hens. It is concluded that prostaglandins play a functional role in oviposition.
D000818:Animals; D002645:Chickens; D005260:Female; D007213:Indomethacin / Q000494:pharmacology; D010058:Oviposition / Q000187:drug effects; D011453:Prostaglandins / Q000502:physiology*; D011458:Prostaglandins E / Q000037:antagonists & inhibitors / Q000097:blood
D011453:Prostaglandins; D011458:Prostaglandins E; D007213:Indomethacin