title: DNCB sensitivity in healthy Pakistani subjects and patients with liver disease.
abstract: Delayed cutaneous hypersensitivity response using DNCB was studied in 51 apparently healthy Pakistanis and 60 patents with acute and chronic liver diseases. A Positive response was observed in all the healthy subjects, 22 out of 29 cases with acute viral hepatitis, 8 out of 22 patients with post-necrotic cirrhosis, one out of three cases of liver cancer and all the cases of alcoholic cirrhosis. It was postulated that hyperactive cell mediated immune response and a heavy exposure to hepatitis virus may be resonsible for the observed pattern of liver disease in Pakistan.
mesh_terms: D000208:Acute Disease; D002908:Chronic Disease; D004137:Dinitrochlorobenzene / Q000276:immunology; D005260:Female; D006525:Hepatitis, Viral, Human / Q000276:immunology; D006801:Humans; D006968:Hypersensitivity, Delayed; D007111:Immunity, Cellular; D008103:Liver Cirrhosis / Q000276:immunology; D008104:Liver Cirrhosis, Alcoholic / Q000276:immunology; D008107:Liver Diseases / Q000276:immunology*; D008113:Liver Neoplasms / Q000276:immunology; D008297:Male; D010154:Pakistan
chemical_list: D004137:Dinitrochlorobenzene