Depression by ethionine of phosphorylating oxidation in hepatic mitochondria.
Induction of hepatic steatosis and suppression of hepatic ATP levels, protein synthesis and gluconeogenesis subsequent to administration of ethionine may be consequences of interference by this compound with mitochondrial phosphorylation of ADP. The mitochondrial dysfunction is not a direct action of ethionine on the organelle.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D005001:Ethionine / Q000494:pharmacology*; D005971:Glutamates / Q000378:metabolism; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D014176:Protein Biosynthesis; D051381:Rats; D013386:Succinates / Q000378:metabolism
D005971:Glutamates; D013386:Succinates; D000255:Adenosine Triphosphate; D005001:Ethionine