[Selective action on hypophyseal gonadotropic function of a new compound from the group of aromatic series sulfur derivatives].
Chronic experiments set up on rats showed the new original drug izm-931, a sulphoderivative of the aromatic series with a rigid molecular structure, to produce, depending upon its dose and reactivity of the hypothalamus-hypophysogonads, regulation system both stimulating and inhibiting gonadotropic effect. At the same time the drug produces neither peripheral nor estrogenic and antiestogenic action on the uterus and vaginal epithelium. The drug resembles but has a number of advantages over and differences with an earlier synthetized by the authors drug sigetin, whose pharmacological properties are close to the one under consideration. The synthesis and study of compounds of this kind are aimed at the search for new effective medicinal agents with an elective type of action on the gonadotropic function of the hypophysis which are of interest for the obstetric and gynecological practice. The present investigation is a new step towards solving this urgent problem of pharmacology in dealing with neuroendocrine regulation of the reproductive function.
D000818:Animals; D002369:Castration; D006063:Chorionic Gonadotropin / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D004967:Estrogens / Q000494:pharmacology; D005260:Female; D006065:Gonadotropins, Pituitary / Q000502:physiology*; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy; D051379:Mice; D008809:Mice, Inbred C3H; D010053:Ovary / Q000187:drug effects; D010902:Pituitary Gland / Q000187:drug effects*; D051381:Rats; D012621:Seasons; D013454:Sulfoxides / Q000494:pharmacology
D006063:Chorionic Gonadotropin; D004967:Estrogens; D006065:Gonadotropins, Pituitary; D013454:Sulfoxides
Izbiratel'noe deĭstvie na gonadotropnuiu funktsiiu gipofoza novogo soedineniia iz gruppy sul'foproizvodnykh aromatic-heskogoriada.