title: Genetic markers in Malaysians: variants of soluble and mitochondrial glutamic oxaloacetic transaminase and salivary and pancreatic amylase, phosphoglucomutase III and saliva esterase polymorphisms.
abstract: Malaysians of Malay, Chinese, and Indian ancestries were electrophoretically phenotyped for Amy1 and saliva esterase region 1 (Set-1) from saliva, Amy2 from plasma, soluble and mitochondrial GOT and PGM3 from leukocyte and placenta. Kadazans and Bajaus, the indigenous people of Sabah, East Malaysia were surveyed for Amy2. Three types of variants were observed for Amy1, one type for Amy2. Only Indians were found to be polymorphic for Amy1. Two GOTs 2-1 and three GOTm 2-1 variants were found among 281 Chinese while three GOTm 2-1 variants were found among 311 Malays. Malaysian Malays, Chinese, and Indians were found to be polymorphic for Set-1 and PGM3. The gene frequencies in Malays are Set-1F=0.601 +/- 0.021, Set-1S = 0.399 +/- 0.021; PGM13 = 0.788 +/- 0.020, PGM23 = 0.212 +/- 0.020; in Chinese Set-1F = 0.497 +/- 0.028, Set-1S = 0.503 +/- 0.028; PGM13 = 0.745 +/- 0.24, PGM23 = 0.255 +/- 0.024; in Indians, Set-1F = 0.449 +/- 0.031, Set-1S = 0.551 +/- 0.031; PGM13 = 0.755 +/- 0.029, PGM23 = 0.245 +/- 0.029.
mesh_terms: D000681:Amylases / Q000235:genetics*; D001219:Aspartate Aminotransferases / Q000235:genetics*; D004950:Esterases / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008296:Malaysia; D008928:Mitochondria / Q000201:enzymology; D010179:Pancreas / Q000201:enzymology; D010641:Phenotype; D010733:Phosphoglucomutase / Q000235:genetics*; D010920:Placenta / Q000201:enzymology; D011110:Polymorphism, Genetic; D011247:Pregnancy; D012463:Saliva / Q000201:enzymology
chemical_list: D001219:Aspartate Aminotransferases; D004950:Esterases; D000681:Amylases; D010733:Phosphoglucomutase