A comparison of the oximes HS-6 and HI-6 in the therapy of soman intoxication in rodents.
The bisquaternary mono-oximes HS-6 and HI-6 may both be considered as potential therapeutic agents for soman intoxication. It has been found that HI-6 was superior to an equal dose of /S-6 in the treatment of soman intoxication in mice and rats. Not only did HI-6 protect against higher levels of soman, but also fewer "delayed deaths" were seen following HI-6. In anesthetized atropinized rats, the administration of HI-6 resulted in a longer duration of spontaneous breathing and a higher degree of recovery of neuromuscular function than did the use of HS-6. HS-6 interacted with soman to alter the rate of excretion of the oxime. This problem was not encountered when HI-6 was used.
D000818:Animals; D001285:Atropine / Q000627:therapeutic use; D004357:Drug Synergism; D005260:Female; D008297:Male; D051379:Mice; D009469:Neuromuscular Junction / Q000187:drug effects; D062025:Organophosphate Poisoning; D010091:Oximes / Q000494:pharmacology / Q000627:therapeutic use* / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D012119:Respiration / Q000187:drug effects; D012999:Soman / Q000506:poisoning*
D010091:Oximes; D001285:Atropine; D012999:Soman