Inhibition of two human tumor cell lines by antimetabolites of coenzyme Q10.
5-Chloro-2,3-dimethyoxy-6-octylmercapto-1,4-benzoquinone (NSC 252188) and 2,3-dimethoxy-5-hydroxy-6-phytyl-1,4-benzoquinone (NSC 277818) inhibited the human cell lines 4265 and K 562c, and the experimental animal tumor line W256; they also showed antitumor activity against Walker carcinosarcoma 256 in rats with cures; they also inhibited the mitochondrial coenzyme Q10-enzymes, succinoxidase and NADH-oxidase. 5-Chloro-2,3-dimethoxy-6-n-dodecylmercapto-1,4-benzoquinone (NSC 220334) and 5-chloro-6-omega-cyclohexylhexylmercapto-2,3-dimethoxy-1,4-benzoquinone (NSC 238136) were also active against the K 562c cell line and showed cures against the Walker carcinosarcoma 256 in rats.
D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D002460:Cell Line; D006801:Humans; D051379:Mice; D009247:NADH, NADPH Oxidoreductases / Q000037:antagonists & inhibitors; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D011809:Quinones / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D011916:Rats, Inbred F344; D013385:Succinate Dehydrogenase / Q000037:antagonists & inhibitors; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use
D000964:Antimetabolites, Antineoplastic; D011809:Quinones; D014451:Ubiquinone; D013385:Succinate Dehydrogenase; D009247:NADH, NADPH Oxidoreductases