[Absence of hydroxyindole O-methyltransferase, the terminal enzyme in melatonin synthesis, in the rat intestine].
The absence of hydroxinol-o-methyltrapherase, the terminal enzyme in the chain of melatonin biosynthesis in the gastrointestinal tract of rats was revealed by means of radioisotopic biochemical methods. A high endogenous methylation in the mucosa of the small intestine of rats with the participation of S-adenozylmethionine, differing from melatonin synthesis in the epiphysis, was revealed during this study.
D000121:Acetylserotonin O-Methyltransferase / Q000172:deficiency*; D000818:Animals; D002250:Carbon Radioisotopes; D007413:Intestinal Mucosa / Q000201:enzymology; D007421:Intestine, Small / Q000201:enzymology; D007422:Intestines / Q000201:enzymology*; D008297:Male; D008550:Melatonin / Q000096:biosynthesis*; D008745:Methylation; D008780:Methyltransferases / Q000172:deficiency*; D010870:Pineal Gland / Q000201:enzymology; D051381:Rats; D012436:S-Adenosylmethionine / Q000378:metabolism; D012701:Serotonin / Q000031:analogs & derivatives / Q000378:metabolism
D002250:Carbon Radioisotopes; D012701:Serotonin; D012436:S-Adenosylmethionine; D008780:Methyltransferases; D000121:Acetylserotonin O-Methyltransferase; D008550:Melatonin
Otsutstvie v kishechnike krys gidroksiindol-O-metiltransferazy, terminal'nogo fermenta sinteza melatonina.