title: Plasma codeine and morphine concentrations after therapeutic oral doses of codeine-containing analgesics.
abstract: Plasma concentrations of codeine and morphine were determined by specific radioimmunoassays in healthy human subjects at various times following oral administration of analgesic preparations containing therapeutic doses of codeine phosphate. Following administration of codeine phosphate (60 mg) in combination with aspirin (650 mg) or acetaminophen (600 mg) to two separate groups, mean peak codeine plasma concentrations and beta-phase elimination half-lives were 159 ng/ml and 2.9 hr or 138 ng/ml and 2.4 hr, respectively. Mean maximum concentrations of metabolically produced morphine were 6.8 ng/ml (aspirin-codeine phosphate administration) and 7.4 ng/ml (acetaminophen-codeine phosphate). Following drug administration, the mean ratio of the areas under the respective plasma concentration-time curves for morphine and codeine was 0.095 for the aspirin-codeine phosphate study and 0.12 for the acetaminophen-codeine phosphate study. Thus, free morphine represented about 10% of the free codeine area in each case. These results support the hypothesis that metabolically produced morphine may influence or be responsible for the analgesic efficacy of codeine.
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage; D001241:Aspirin / Q000008:administration & dosage; D001711:Biotransformation; D003061:Codeine / Q000008:administration & dosage / Q000097:blood*; D004338:Drug Combinations; D006801:Humans; D007700:Kinetics; D008297:Male; D009020:Morphine / Q000097:blood*
chemical_list: D004338:Drug Combinations; D000082:Acetaminophen; D009020:Morphine; D001241:Aspirin; D003061:Codeine