title: Binding of polynucleotides to fibroblasts. Effects of complex formation with vinyl analogs of nucleic acids.
abstract: The binding of polynucleotides or of their vinyl analogs to human fibroblasts is changed when complexes are formed between these compounds. The following polymers have been studied: poly(1-vinylcytosine), poly(1-vinyluracil, poly(9-vinyladenine), polyuridylate, polyadenylate and polyinosinate. Only that complex formation (between poly(1-vinylcytosine) and polyinosinate) which is accompanied by aggregation leads to a considerable increase (30 fold) in binding to cells; all the other complex formations have only moderate effects (0.2-3 fold). Furthermore, a comparison of unordered complexes containing polyinosinate whows that enhanced binding to cells is paralleled by an increased cellular resistance to viral infection.
mesh_terms: D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism*; D011063:Poly A-U / Q000031:analogs & derivatives / Q000378:metabolism; D011070:Poly I-C / Q000031:analogs & derivatives / Q000378:metabolism; D011119:Polynucleotides / Q000378:metabolism*; D011145:Polyvinyls / Q000378:metabolism*
chemical_list: D011119:Polynucleotides; D011145:Polyvinyls; D011063:Poly A-U; D011070:Poly I-C