Experimental myocardial infarction in dogs with normal coronary arteries. Angiographic resolution of coronary arterial emboli.
Percutaneous transcatheter embolization of the coronary arteries with autologous clot was performed in six dogs. The occlusions resolved completely within 14 days in the four surviving dogs. Postmortem examination revealed transmural myocardial infarction in two dogs and subendocardial infarcts in the other two. Histological sections showed no residual emboli in three dogs and a recanalized thrombus in an epicardial vessel in the fourth. These findings indicate that myocardial infarction can be produced by multiple occlusions of the distal coronary arterial branches, provided that common or contiguous myocardium is affected. The recanalized thrombus in one dog suggests that the thrombolytic process need not be complete for return to a normal angiographic appearance.
D000792:Angiography; D000818:Animals; D017023:Coronary Angiography; D003331:Coronary Vessels / Q000473:pathology; D004195:Disease Models, Animal; D004285:Dogs; D004617:Embolism / Q000000981:diagnostic imaging / Q000473:pathology; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000473:pathology