Effects of cyanein and ramihyphin A on the dimorphism of Paracoccidioides brasiliensis.
As a preliminary step in the study of dimorphism in Paracoccidioides brasiliensis, the effects of cyanein and ramihyphin A were studied. These antibiotics have been reported to induce morphological changes in fungi. The results obtained suggest that ramihyphin A induce swelling of hyphae while partially inhibiting Y leads to M transformation with the production of an incipient and swollen mycelium. Cyanein did not affect the mycelial morphology as did ramihyphin A. However, the Y leads to M transformation was inhibited and, also, the M leads to Y transformation was blocked with the production of a few yeast cells which were not released from the mycelium.
D000935:Antifungal Agents / Q000494:pharmacology*; D003517:Cyclopentanes / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects*; D010228:Paracoccidioides / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development; D011110:Polymorphism, Genetic / Q000187:drug effects*; D014170:Transformation, Genetic / Q000187:drug effects
D000935:Antifungal Agents; D003517:Cyclopentanes