Effect of niridazole on the lipid pattern of the parasite and host tissues in experimental schistosomiasis mansoni.
THE LIPID pattern of blood and liver of mice infected with S. mansoni as well as in male and female worms was studied. Experiments were also carried out on non-infected and infected mice after treatment with Niridazole. It was found that Niridazole caused a significant increase in liver triglycerides and serum free acids. These changes were more pronounced in non-infected animals than in infected ones. The drug was found to reduce worm phospholipids and to increase their triglyceride level. The male worms were more affected than the female ones.
D000818:Animals; D008099:Liver / Q000378:metabolism*; D008297:Male; D051379:Mice; D009560:Niridazole / Q000494:pharmacology* / Q000627:therapeutic use; D010743:Phospholipids / Q000097:blood / Q000378:metabolism*; D012550:Schistosoma mansoni; D012552:Schistosomiasis / Q000188:drug therapy / Q000378:metabolism*; D014280:Triglycerides / Q000097:blood / Q000378:metabolism*
D010743:Phospholipids; D014280:Triglycerides; D009560:Niridazole