Biomodification of albocycline by Streptomyces venezuelae.
The macrolide antibiotic albocycline, when added to the fermentations of Streptomyces venezuelae UC-2560 (WC-3627) underwent a gradual loss of antimicrobial activity. The inactive product of this biotransformation was isolated from the fermentations and was shown to be 2,3-dihydroalbocycline.
D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000378:metabolism*; D001711:Biotransformation; D055598:Chemical Phenomena; D002621:Chemistry; D005285:Fermentation; D007783:Lactones; D013302:Streptomyces / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D007783:Lactones