Some studies on the enzyme lecithin-cholesterol acyl-transferase in rat plasma.
The results presented in this study, which include different physiological and pathological conditions, show: 1--In the rat subjected to bile duct occlusion there is a rapid decrease in the plasma LCAT activity which is followed by an increase in the activity to normal values at a later time. 2--In the rat subjected to interruption of the enterohepatic circulation of bile salts by means of a sequestering agent there is an increase in the plasma LCAT activity. 3--In the rat subjected to a 48 hour fast there is an increase in the plasma LCAT activity. 4--In the rat subjected to a small dietary cholesterol supplement there is an increase in the plasma LCAT activity.
D000818:Animals; D001647:Bile Acids and Salts / Q000494:pharmacology; D001652:Bile Ducts / Q000502:physiology; D002784:Cholesterol / Q000096:biosynthesis / Q000378:metabolism*; D002791:Cholesterol, Dietary / Q000378:metabolism; D002792:Cholestyramine Resin / Q000494:pharmacology; D004764:Enterohepatic Circulation / Q000187:drug effects; D005215:Fasting; D008099:Liver / Q000378:metabolism; D008297:Male; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000097:blood*; D010743:Phospholipids / Q000097:blood*; D011863:Radioimmunoassay; D051381:Rats; D002785:Sterol O-Acyltransferase / Q000097:blood
D001647:Bile Acids and Salts; D002791:Cholesterol, Dietary; D010743:Phospholipids; D002792:Cholestyramine Resin; D002784:Cholesterol; D002785:Sterol O-Acyltransferase; D007862:Phosphatidylcholine-Sterol O-Acyltransferase