title: [Toxicological properties of a cephedrine preparation].
abstract: The antidepressant drug cephedrine experimentally displays a little acute and chronic toxicity, does not influence the development of allergic reaction in guinea pigs, changes but little the ECG and does not possess teratogenic and embryotoxic properties. When used in a subtoxic dose it is capable of causing dystrophic changes in individual neurons in the cortex and subcortical formations of the central nervous system, to delay the growth of fetuses, especially when administered during the second half of gestation.
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000276:immunology / Q000633:toxicity*; D002490:Central Nervous System / Q000187:drug effects; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D005260:Female; D005333:Fetus / Q000187:drug effects; D006168:Guinea Pigs; D007928:Lethal Dose 50; D051379:Mice; D009570:Nitriles / Q000276:immunology / Q000633:toxicity; D011247:Pregnancy; D011412:Propanolamines / Q000276:immunology / Q000633:toxicity*; D051381:Rats; D013723:Teratogens; D013997:Time Factors
chemical_list: D000928:Antidepressive Agents; D009570:Nitriles; D011412:Propanolamines; D013723:Teratogens
vernacular_title: Toksikologicheskie svoĭstva preparata tsefedrina.