Left ventricular pump failure associated with diffuse coagulation in experimental intraoperative autotransfusion.
Autotransfusion of blood from the peritoneal cavity of pigs under a regimen of acid citrate dextrose solution 1:10 v/v for reservoir anticoagulation or systemic heparinization with 300 Iu/kg did not affect cardiac performance. Rapid deterioration of left ventricular pump performance was observed when low dose systemic heparin 100 Iu/kg was used. Evidence suggests that this is related to diffuse coagulation.
D000818:Animals; D000925:Anticoagulants / Q000009:adverse effects; D001777:Blood Coagulation / Q000187:drug effects*; D001804:Blood Transfusion, Autologous / Q000009:adverse effects / Q000379:methods*; D004211:Disseminated Intravascular Coagulation / Q000209:etiology* / Q000503:physiopathology; D005947:Glucose / Q000494:pharmacology; D006352:Heart Ventricles / Q000503:physiopathology*; D006439:Hemodynamics / Q000187:drug effects*; D006493:Heparin / Q000494:pharmacology; D013552:Swine
D000925:Anticoagulants; D006493:Heparin; D005947:Glucose