Orotic acid: its influence on nuclear RNA and microsomal protein synthesis in brain cells of undernourished rat pups.
Malnourished rat pups were supplemented with orotic acid. RNA-synthesizing activity of isolated brain cell nuclei and microsomal protein synthesis was measured in vitro. A marked increase was found in the activity of nuclear RNA synthesis but not in microsomal protein synthesis after orotic acid treatment for 7 days.
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000166:cytology* / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism*; D005260:Female; D008861:Microsomes / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D009748:Nutrition Disorders / Q000188:drug therapy*; D009963:Orotic Acid / Q000627:therapeutic use*; D011247:Pregnancy; D012313:RNA / Q000096:biosynthesis*; D051381:Rats
D009419:Nerve Tissue Proteins; D009963:Orotic Acid; D012313:RNA