title: Association between HLA and red cell antigens. V. A further study of the nature and behaviour of the HLA antigens on red blood cells and their corresponding haemagglutinins.
abstract: The variation in the reactivity of red blood cells (RBC) with HLA haemagglutinins was studied, and the influence of some variable factors evaluated. A comparison of the HLA reactivity of RBC with automated and manual methods, showed the superiority of the Auto-Analyzer technique. The similarity in the nature and behaviour of HLA RBC antigens and the related Chido and Rg antigens is discussed. Inhibition/adsorption experiments were performed, and the results did not support the theory that HLA antigens on RBC originate from serum-HLA-active substance. The strength of the HLA reactivity of RBC from a donor was shown to vary from time to time without evidence of clinical disease.
mesh_terms: D001322:Autoanalysis; D001782:Blood Donors; D003601:Cytotoxicity Tests, Immunologic; D004912:Erythrocytes / Q000276:immunology*; D006680:HLA Antigens; D006801:Humans; D011309:Preservation, Biological
chemical_list: D006680:HLA Antigens