Hb J Camaguey alpha 2 141(HC3) Arg replaced by Gly beta 2: a new abnormal human hemoglobin.
An electrophoretic fast-moving hemoglobin was found in a Cuban family of Spanish descent. Structural studies demonstrated a replacement of arginine by glycine at alpha 141(HC3). This change is not associated with clinical symptoms, although the substitution is in one of the residues involved in the stabilization of the deoxy form of the hemoglobin molecule.
D000596:Amino Acids; D002648:Child; D002852:Chromatography, Ion Exchange; D003462:Cuba; D004592:Electrophoresis, Starch Gel; D005914:Globins; D006448:Hemoglobin J / Q000302:isolation & purification*; D006455:Hemoglobins, Abnormal / Q000302:isolation & purification*; D006801:Humans; D008297:Male
D000596:Amino Acids; D006455:Hemoglobins, Abnormal; D006448:Hemoglobin J; D005914:Globins