Monocyte function in patients with solid neoplasms during immunotherapy with Corynebacterium parvum.
The present studies were performed in order to evaluate monocyte function in patients with solid neoplasms before and after administration of C. parvum. The results demonstrate that monocytes from cancer patients display increased numbers of C3 and Fc receptor sites after administration of C. parvum. It is concluded that characterization of monocyte receptor activity may be helpful in monitoring the effects of immunotherapy in the immune system.
D002634:Chemotaxis, Leukocyte; D003176:Complement C3; D005260:Female; D006801:Humans; D007141:Immunoglobulin Fc Fragments; D007167:Immunotherapy; D066298:In Vitro Techniques; D008297:Male; D009000:Monocytes / Q000276:immunology*; D009113:Muramidase / Q000097:blood; D009369:Neoplasms / Q000201:enzymology / Q000276:immunology* / Q000628:therapy; D011425:Propionibacterium acnes / Q000276:immunology*
D003176:Complement C3; D007141:Immunoglobulin Fc Fragments; D009113:Muramidase