title: The interstitial cells in the renal medulla of rat, rabbit, and gerbil in different states of diuresis.
abstract: The inner zone of the renal medulla of rats, gerbils, and rabbits was investigated to determine whether or not there are any characteristic ultrastructural differences between the interstitial cells of these species. The effects on the interstitial cells of water deprivation and water loading were also investigated. In all three species, the Type 1 interstitial cells, the lipid containing cells, were abundant and their distribution and topographical relations as well as their general ultrastructure were similar. The previously reported significantly higher frequency in desert rats could not be confirmed. Although the lipid droplets of the interstitial cells were smaller in gerbils and rabbits when compared to rats, their fine structure was similar. Their electron dense outer zone was sometimes associated with a granular material and/or a lamellar material with a periodicity of about 40 A resembling phospholipid "myelin figures". Water-loaded rats showed a considerable increase in the number of lipid droplets when compared to dehydrated or untreated animals. In contrast, the interstitial cells of waterloaded gerbils and rabbits were depleted of lipid droplets.
mesh_terms: D000818:Animals; D003238:Connective Tissue / Q000648:ultrastructure; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D004231:Diuresis; D005260:Female; D005849:Gerbillinae; D007668:Kidney / Q000648:ultrastructure*; D007679:Kidney Medulla / Q000648:ultrastructure*; D008055:Lipids; D008297:Male; D011817:Rabbits; D051381:Rats; D013045:Species Specificity
chemical_list: D008055:Lipids