Differential effects of cranial radiation on growth hormone response to arginine and insulin infusion.
The growth hormone responses to arginine infusion and to insulin-induced hypoglycemia were studied in 13 patients with neoplastic disease after treatment with radiation and chemotherapy. Patients who received intensive cranial radiation (greater than 2,400 rads) had no response to either arginine or insulin; those who received moderate cranial radiation (greater than or equal to 2,400 rads) had GH response to arginine but not to insulin; patients receiving no cranial radiation responded to both arginine and insulin. These data support the hypothesis that GH secretion in response to arginine infusion has a different mechanism in contrast to the response to insulin-induced hypoglycemia and that the latter is more vulnerable to cranial radiation.
D000293:Adolescent; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001120:Arginine / Q000008:administration & dosage / Q000494:pharmacology*; D001921:Brain / Q000528:radiation effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D007003:Hypoglycemia / Q000503:physiopathology; D007223:Infant; D007263:Infusions, Parenteral; D007328:Insulin / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D009369:Neoplasms / Q000188:drug therapy / Q000532:radiotherapy
D000970:Antineoplastic Agents; D007328:Insulin; D013006:Growth Hormone; D001120:Arginine