Rapid miniaturized chromatographic quality control procedures for iodinated radiopharmaceuticals.
A rapid, miniaturized chromatographic system was developed to determine the labeling efficiency of iodinated radio-pharmaceuticals including I-131 orthoiodohippurate, I-131 rose bengal, I-125 RISA, and I-131 19-iodocholesterol. The system consists of three specific chromatography strips (Whatman 31ET paper chromatography, silica gel and silicic acid instant thin-layer chromatography) and three solvents (chloroform:glacial acetic acid in a 1.00:0.05 v/v mixture, absolute methanol, and 0.9% sodium chloride). The strips are color-coded, miniaturized, and appropriately labeled. The chromatographic quality control procedures are easy to use, rapid, and can be incorporated easily in a routine quality control program.
D002845:Chromatography / Q000379:methods*; D002854:Chromatography, Paper; D002855:Chromatography, Thin Layer; D007457:Iodine Radioisotopes; D007553:Isotope Labeling / Q000592:standards*; D011786:Quality Control
D007457:Iodine Radioisotopes