[Diuretic activity of benzimidazole urea derivatives].
The chemical structure of benzimidazol urea derivatives and physico-chemical properties of these compounds conditioned by it play a significant role in the manifestation of the emictory effect. Among the study substances a number of compounds displaying a marked, but short-lived diuretic action have been educed. In the manifestation of emictory properties in benzimidazol urea derivatives of importance is the character of the side chain and its ramification and also an even number of carbon atoms in the acyl radical.
D000818:Animals; D001562:Benzimidazoles; D004231:Diuresis / Q000187:drug effects; D004232:Diuretics / Q000494:pharmacology*; D005260:Female; D008297:Male; D051381:Rats; D013329:Structure-Activity Relationship; D013997:Time Factors; D014508:Urea / Q000031:analogs & derivatives*
D001562:Benzimidazoles; D004232:Diuretics; D014508:Urea
Diureticheskaia aktivnost' benzimidazol'nykh proizvodnykh mocheviny.