[Effect of steroid hormones on glutamate dehydrogenase activity in rat liver mitochondria].
Steroid hormones (sex hormones and corticosteroids) were found to inhibite the activity of glutamate dehydrogenase from rat liver mitochondria in vitro. After blocking of arginine guanidine groups in the mitochondrial preparations the inhibitory effect of sex hormones was decreased and that of corticosteroids - prevented. The data obtained suggest that guanidine groups of arginine residues in glutamate dehydrogenase participate in realization of the inhibitory effect of steroid hormones.
D000305:Adrenal Cortex Hormones / Q000494:pharmacology*; D000818:Animals; D003900:Desoxycorticosterone / Q000494:pharmacology; D004054:Diethylstilbestrol / Q000494:pharmacology; D045166:Estradiol Congeners / Q000494:pharmacology*; D005969:Glutamate Dehydrogenase / Q000037:antagonists & inhibitors*; D012739:Gonadal Steroid Hormones / Q000494:pharmacology*; D006589:Hexestrol / Q000494:pharmacology; D006854:Hydrocortisone / Q000494:pharmacology; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000201:enzymology; D011374:Progesterone / Q000494:pharmacology; D051381:Rats; D013739:Testosterone / Q000494:pharmacology
D000305:Adrenal Cortex Hormones; D045166:Estradiol Congeners; D012739:Gonadal Steroid Hormones; D006589:Hexestrol; D013739:Testosterone; D003900:Desoxycorticosterone; D011374:Progesterone; D004054:Diethylstilbestrol; D005969:Glutamate Dehydrogenase; D006854:Hydrocortisone
Vliianie steroidnykh gormonov na aktivnost' glutamatdegidrogenazy mitokhondriĭ pecheni krys.