Sephadex-gel filtration (SGF) in infant and adult Gunn rats.
SGF was compared in infant and adult homozygous Gunn rats. Without any drug application, the test was negative in the adult animals, whereas a remarkable percentage of positive SGF was obtained in 5-7-day-old rats, especially in those undernourished and/or intensely icteric. Unexpectedly, in infant rats the rate of positive SGF after sulfadimethoxine injection was lower than in the untreated control group. Moreover, in 9-10-day-old animals who had positive SGF before the injection, the test became negative 15-20 min after sulfadimethoxine application in vivo. No convincing explanation could be given, but drug interference with the binding capacities of the Sephadex column could be excluded by appropriate in vitro tests.
D000367:Age Factors; D000818:Animals; D001663:Bilirubin / Q000097:blood*; D002850:Chromatography, Gel; D007565:Jaundice / Q000097:blood*; D009748:Nutrition Disorders / Q000097:blood; D051381:Rats; D012709:Serum Albumin / Q000032:analysis*; D013412:Sulfadimethoxine / Q000008:administration & dosage
D012709:Serum Albumin; D013412:Sulfadimethoxine; D001663:Bilirubin