Resistance of a substrain of Wistar rats to salt hypertension.
Male rats of the Wistar substrain, in which 2/3 nephrectomy was performed, did not develop hypertension when placed on a high salt intake, while rats of the Long-Evans substrain become hypertensive under the same conditions. The described substrain of Wistar rats represents a useful experimental model for studying the mechanism of resistance to the hypertensive stimulus of salt overload.
D000818:Animals; D001794:Blood Pressure; D006973:Hypertension / Q000139:chemically induced* / Q000503:physiopathology; D008297:Male; D009392:Nephrectomy; D051381:Rats / Q000235:genetics / Q000502:physiology*; D012965:Sodium Chloride / Q000494:pharmacology*; D013045:Species Specificity; D013997:Time Factors
D012965:Sodium Chloride