title: [Effect of x-ray contrast substances on the metabolism of xenobiotics and steroid hormones by rat liver microsomes].
abstract: Uro- and cholecystographic contrast media are shown to be capable of changing the rate of oxidative hydroxylation of amidopyrine and steroid hormones. The degree and duration of the diminishing rate of the xenobiotics and steroids metabolism are determined by concentrations of the X-ray contrast media in hepatic cells and the rate of their clearance.
mesh_terms: D000632:Aminopyrine / Q000378:metabolism*; D000818:Animals; D003287:Contrast Media / Q000494:pharmacology*; D003864:Depression, Chemical; D004958:Estradiol / Q000378:metabolism*; D006900:Hydroxylation; D007455:Iodine; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects*; D010084:Oxidation-Reduction; D051381:Rats; D013739:Testosterone / Q000378:metabolism*
chemical_list: D003287:Contrast Media; D000632:Aminopyrine; D013739:Testosterone; D004958:Estradiol; D007455:Iodine
vernacular_title: Vliianie rentgenokontrastnykh veshchestv na metabolizm ksenobiotikov i steroidnykh gormonov mikrosomami pecheni krys.