title: [Toxic "atrophie cerebelleuse". (problems associated with permanent cerebellar damage due to chronic diphenylhydantion intoxication)].
abstract: The authors report two cases with roentgenomophologically established cerebellar atrophy caused by chronic diphenylhydantoin overdosing. Exact neuropsychiatric testing of epileptics treated with diphenylhydantoin for a long period of time is demanded, and it is recommended that in the case of long-time therapy a maximum daily dose of 0.3 g of diphenylhydantoin be not exceeded.
mesh_terms: D000328:Adult; D001284:Atrophy; D001925:Brain Damage, Chronic / Q000139:chemically induced* / Q000000981:diagnostic imaging; D002526:Cerebellar Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging; D004827:Epilepsy / Q000188:drug therapy; D005260:Female; D006801:Humans; D010672:Phenytoin / Q000009:adverse effects* / Q000627:therapeutic use; D011859:Radiography
chemical_list: D010672:Phenytoin
vernacular_title: Toxische "Atrophie cérébelleuse" (Zur Problematik der Kleinhirndauerschädigung infolge chronischer Diphenylhydantoinintoxikation).