title: Differential agglutination of particulate Vi and O antigens by the IgM and IgG class antibodies.
abstract: The IgG and IgM immunoglobulins were fractionated from pooled sera of typhoid patients and typhoid carriers and the agglutinin titres and weights of Vi and O antibodies in these immunoglobulin fractions determined. The O antigen particles were more effectively agglutinated than the Vi antigen particles by their corresponding antibodies of the IgM class. There was no such difference between IgG class Vi and O antibodies. Similar behaviour was found on indirect estimation of the agglutination capacity of the IgG and IgM class Vi and O antibodies in the sera of individual typhoid patients or carriers. The significance of such differential agglutinating capacity of the Vi and O antibodies of the IgM class is discussed.
mesh_terms: D000371:Agglutination; D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D002353:Carrier State / Q000276:immunology; D006384:Hemagglutination; D006801:Humans; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012485:Salmonella typhi / Q000276:immunology*; D014435:Typhoid Fever / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D007074:Immunoglobulin G; D007075:Immunoglobulin M