Special considerations with regard to the dosage of tranexamic acid in patients with chronic renal diseases.
Tranexamic acid is a potent antifibrinolytic drug frequently used in the treatment of haematuria and a number of other haemorrhagic conditions. Since it is eliminated mainly in the urine, the drug accumulates in patients with uraemia. The excretion of tranexamic acid in patients with renal failure has been investigated and dosage recommendations are given for tranexamic acid therapy in cases of renal failure.
D001682:Biological Availability; D002908:Chronic Disease; D003404:Creatinine / Q000097:blood; D003509:Cyclohexanecarboxylic Acids / Q000008:administration & dosage*; D005921:Glomerulonephritis / Q000188:drug therapy; D006207:Half-Life; D006417:Hematuria / Q000188:drug therapy; D006801:Humans; D007275:Injections, Intravenous; D007668:Kidney / Q000378:metabolism; D007674:Kidney Diseases / Q000378:metabolism*; D007676:Kidney Failure, Chronic / Q000188:drug therapy; D009400:Nephrosclerosis / Q000188:drug therapy; D011704:Pyelonephritis / Q000188:drug therapy; D014148:Tranexamic Acid / Q000008:administration & dosage* / Q000378:metabolism / Q000627:therapeutic use; D014555:Urination Disorders / Q000188:drug therapy
D003509:Cyclohexanecarboxylic Acids; D014148:Tranexamic Acid; D003404:Creatinine