The sensitization potential of some perfume ingredients tested using a modified draize procedure.
A modified Draize procedure was used to test 23 natural and 46 synthetic perfume ingredients for their potential to induce allergic contact dermatitis in guinea pigs. Fifty-three ingredients did not induce sensitization. Two synthetic ingredients showed a strong sensitization potential and 14 ingredients, 7 natural and 7 synthetic, showed a weak sensitization potential. The findings indicate that there is little risk of sensitization in man to most of these perfume ingredients.
D000818:Animals; D001597:Benzylidene Compounds / Q000633:toxicity; D003876:Dermatitis, Atopic / Q000139:chemically induced*; D003877:Dermatitis, Contact / Q000209:etiology*; D005260:Female; D006168:Guinea Pigs; D008297:Male; D010476:Perfume / Q000633:toxicity*
D001597:Benzylidene Compounds; D010476:Perfume