The metabolism of azidomorphine in a human subject.
1. The metabolism of azidomorphine, a potent narcotic analgesic, was studied in a human subject who had received a single 1.8 mg dose subcutaneously. 2. Azidomorphine was excreted in the urine in small amounts as the intact drug and as a metabolite, 6-deoxy-6beta-aminodihydromorphine. Larger amounts of conjugated azidomorphine also were detected. 3. The azido group of azidomorphine was relatively stable towards enzymic and chemical change.
D000328:Adult; D001711:Biotransformation; D004355:Drug Stability; D006801:Humans; D006868:Hydrolysis; D008297:Male; D009022:Morphine Derivatives / Q000378:metabolism*
D009022:Morphine Derivatives; C006659:azidomorphine