Mathematical basis of point-area deconvolution method for determining in vivo input functions.
The point-area method for deconvolution derives a "staircase" input function which, when convolved onto the characteristic function, gives an output function coincidental with the given output data points. The area--area method for deconvolution is shown to be erroneous.
D008433:Mathematics; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D012995:Solubility
D004364:Pharmaceutical Preparations