title: Thrombin-induced platelet aggregation is mediated by a platelet plasma membrane-bound lectin.
abstract: Throbin-activated human platelets cause agglutination of trypsinized, formalinized bovine erythrocytes. This lectin activity of stimulated platelets was blocked by galactosamine, glucosamine, mannosamine, lysine, and arginine, but not by N-acetylated sugars, other neutral sugars, or other amino acids. Inhibitors of the thrombin-induced lectin activity also blocked thrombin-induced platelet aggregation. It appears that a membrane surface component that has lectin activity mediates platelet aggregation.
mesh_terms: D000373:Agglutinins; D000596:Amino Acids / Q000494:pharmacology; D000606:Amino Sugars / Q000494:pharmacology; D000818:Animals; D001665:Binding Sites; D003571:Cytochalasin B / Q000494:pharmacology; D006388:Hemagglutinins; D006801:Humans; D008565:Membrane Proteins / Q000097:blood; D010974:Platelet Aggregation / Q000187:drug effects*; D011458:Prostaglandins E / Q000494:pharmacology; D013045:Species Specificity; D013917:Thrombin / Q000494:pharmacology*
chemical_list: D000373:Agglutinins; D000596:Amino Acids; D000606:Amino Sugars; D006388:Hemagglutinins; D008565:Membrane Proteins; D011458:Prostaglandins E; D003571:Cytochalasin B; D013917:Thrombin