title: Neuroendocrine mechanisms mediating the suppression of circulating testosterone levels associated with chronic stress in male rats.
abstract: Neuroendocrine mechanisms involved in the reduction of testosterone (T) levels induced by the chronic surgical stress of s.c. gauze implantation were investigated in male rats. The reduction resulted from a decline in T secretion and not an increase in clearance of the hormone from the circulation. In most cases, the decrement was accompanied by a reduction in LH levels, indicating that decreased LH stimulation is the primary factor mediating the drop in T levels. The suppressive effect of surgical stress on LH and T levels was apparently not mediated by the pituitary-adrenal system.
mesh_terms: D000311:Adrenal Glands / Q000502:physiology; D000818:Animals; D002369:Castration; D005485:Flutamide / Q000494:pharmacology; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D009490:Neurosecretory Systems / Q000503:physiopathology; D051381:Rats; D013312:Stress, Physiological / Q000378:metabolism*; D013739:Testosterone / Q000378:metabolism*
chemical_list: D013739:Testosterone; D005485:Flutamide; D007986:Luteinizing Hormone