Studies of d-tubocurarine pharmacokinetics in humans and dogs.
The pharmacokinetics of d-tubocurarine was studied in man during single and multiple administrations of d-tubocurarine, and in dogs during single administrations. The simplest model consistent with out data was a two-compartment open model. The mean half-lives for the two phases in the human studies were 8.9 and 123.8 minuts. For the greyhounds these mean values were 2.8 and 77.4 minutes. The animals did not demonstrate a difference between the arterial and mixed venous concentrations of d-tubocurarine.
D000328:Adult; D000818:Animals; D004285:Dogs; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D010243:Paralysis / Q000139:chemically induced; D014403:Tubocurarine / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology
D014403:Tubocurarine