Murine ovarian teratomas and parthenotes as cytogenetic tools.
The origin of murine ovarian teratomas and their use to estimate centromere-to-gene distances is discussed. As an example of how such a system can be used, the distance from the centromere of chromosome 7 to the Gpi-1 locus was determined by analyzing the Gpi-1 phenotypes in 47 ovarian teratomas from Gpi-1a/Gpi-1b females. The percent recombination was estimated to be 10.6. It is suggested that ovarian teratomas and parthenotes may be used for half-tetrad analysis.
D000818:Animals; D002875:Chromosomes / Q000648:ultrastructure; D005260:Female; D005796:Genes; D051379:Mice; D008815:Mice, Inbred Strains; D010051:Ovarian Neoplasms / Q000235:genetics*; D010312:Parthenogenesis; D010641:Phenotype; D011995:Recombination, Genetic; D013724:Teratoma / Q000235:genetics*