Suppressive effects of regional lymph node cells and extracts of antibody-dependent cellular cytotoxicity.
Lymphocytes from regional lymph nodes that drain tumors and extracts of such lymphocytes suppress antibody-dependent cell-mediated target cell lysis by effector cells from cancer patients and controls. In contrast, lymph node cells from control patients are not suppressive. Control extracts from normal lymphocytes and 2 immunologically inert tissues, muscle and kidney, exhibit some suppressive activity but significantly less than extracts from lymph nodes that drain tumors.
D000230:Adenocarcinoma / Q000276:immunology; D000328:Adult; D000368:Aged; D000920:Antibody-Dependent Cell Cytotoxicity; D002295:Carcinoma, Transitional Cell / Q000276:immunology; D002470:Cell Survival; D002474:Cell-Free System; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000166:cytology / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000276:immunology; D013736:Testicular Neoplasms / Q000276:immunology; D014020:Tissue Extracts / Q000494:pharmacology*; D001749:Urinary Bladder Neoplasms / Q000276:immunology
D014020:Tissue Extracts