Effect of clofibrate on in vivo triglyceride production and clearance in genetically hyperlipemic rats.
Seventeen hyperlipemic and 17 normolipemic littermate Zucker rats were treated with clofibrate or normal saline to determine the effect of this drug upon hepatic triglyceride (TG) production and peripheral TG disposal. Peripheral Intralipid clearance was not different in hyperlipemic rats relative to control animals. Hyperlipemic animals demonstrated abnormally elevated TG production in the fasted state which was not corrected with clofibrate administration. Following treatment, peripheral Intralipid clearance was increased 100% in hyperlipemic rats, but unchanged in normolipemic animals. These observations provide further evidence that the predominant lipid reducing action of clofibrate is manifested only in the hyperlipemic state, and predominantly upon peripheral lipid disposal.
D000818:Animals; D002994:Clofibrate / Q000627:therapeutic use*; D005260:Female; D006949:Hyperlipidemias / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008657:Metabolic Clearance Rate / Q000187:drug effects; D009765:Obesity / Q000188:drug therapy / Q000378:metabolism; D051381:Rats; D014280:Triglycerides / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000378:metabolism*
D014280:Triglycerides; D002994:Clofibrate