An effect of actin on cell migration.
A specific inhibitory effect on mononuclear cell migration by smooth muscle actin and skeletal muscle actin is reported. Actin aged at 4 degrees C or heated at 56 degrees C for 10 min had little or no effect, but papain-denatured actin had a strong inhibitory action. Actin and/or its breakdown product(s) may interfere with mononuclear cell movement in vivo in pathological conditions where release of actin from damaged or dead cells occurs.
D000199:Actins / Q000494:pharmacology*; D000375:Aging; D000818:Animals; D002465:Cell Movement / Q000187:drug effects*; D006168:Guinea Pigs; D006801:Humans; D008214:Lymphocytes / Q000502:physiology; D008264:Macrophages / Q000502:physiology; D009130:Muscle, Smooth; D011489:Protein Denaturation
D000199:Actins