Mechanism of resistance to thiostrepton in the producing-organism Streptomyces azureus.
An antibiotic-producing organism, Streptomyces azureus, defends itself against its own toxic product by methylating the RNA of its ribosomes.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001665:Binding Sites; D004352:Drug Resistance, Microbial; D006150:Guanine Nucleotides / Q000378:metabolism; D008780:Methyltransferases / Q000378:metabolism; D010445:Peptide Elongation Factors; D012335:RNA, Ribosomal / Q000378:metabolism; D012270:Ribosomes / Q000187:drug effects* / Q000378:metabolism; D013302:Streptomyces / Q000187:drug effects*; D013883:Thiostrepton / Q000378:metabolism / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D006150:Guanine Nucleotides; D010445:Peptide Elongation Factors; D012335:RNA, Ribosomal; D008780:Methyltransferases; D013883:Thiostrepton