Time-dependent effects of reserpine on retention of passive avoidance.
Reserpine produced amnesia for a one-trial passive avoidance task when given 2, 3, 4, 5 hr before but not when given 1, 8, 12, 24 hr or 30 min before, immediately, 90 min or 2, 4, 5, 6, 8, 9, 12, 24 hr following training. The results were discussed in terms of the reserpine effect on biogenic amines and their possible role in memory formation.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D012110:Reserpine / Q000494:pharmacology*; D012153:Retention, Psychology / Q000187:drug effects*; D013997:Time Factors
D012110:Reserpine