Synthesis and biological evaluation of 10-oxa-11-deoxyprostaglandin E1 and 10-nor-9,11-secoprostaglandin F1 and their derivatives.
Three 10-oxa-11-deoxyprostaglandin E1 and two 10-nor-9,11-secoprostaglandin F1 analogues were prepared. The compounds were evaluated for pregnancy interruptions, oxytocin-like activity (uterine strip), and antiprostaglandin activity. One of the 10-nor-9,11-secoprostaglandin F1 analogues displayed activity as a PGE2 antagonist in the gerbil colon smooth muscle preparation.
D000020:Abortifacient Agents, Nonsteroidal; D000818:Animals; D006224:Cricetinae; D005260:Female; D005849:Gerbillinae; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010121:Oxytocin / Q000494:pharmacology; D011247:Pregnancy; D011458:Prostaglandins E / Q000037:antagonists & inhibitors; D011459:Prostaglandins E, Synthetic / Q000138:chemical synthesis* / Q000494:pharmacology; D011461:Prostaglandins F, Synthetic / Q000138:chemical synthesis* / Q000494:pharmacology; D013237:Stereoisomerism; D014590:Uterine Contraction / Q000187:drug effects
D000020:Abortifacient Agents, Nonsteroidal; D011458:Prostaglandins E; D011459:Prostaglandins E, Synthetic; D011461:Prostaglandins F, Synthetic; D010121:Oxytocin