Columnar epidermal necrosis. A special form of toxic epidermal reaction?
A bizzare erythematosquamous, partially verrucose, crustly or eroded eruption developed in a 6-year-old boy one week after his first measles vaccination. The eruption regressed completely after a two-year clinical course. Histologically, the epidermis showed unique columnar eosinophilic degeneration. There was a dense, mononuclear cell infiltration in the upper part of the dermis. To our knowledge these clinical and histologic features have not been reported in the literature, although they resemble, in some aspects, Kyrle's disease, Mucha-Haberman's disease, or lichen planus verrucosus. Regarding the pathomechanisms underlying the development of this unique epidermal change, a postulate was made that it represented a special form of toxic epidermal reaction, probably resulting from autoagressive lymphoid cell response to epidermal cells. Furthermore, relationship of measles vaccination to this special response is suggested.
D002648:Child; D007644:Darier Disease / Q000473:pathology; D006801:Humans; D008010:Lichen Planus / Q000473:pathology; D008297:Male; D010915:Pityriasis / Q000473:pathology; D012867:Skin / Q000473:pathology; D013262:Stevens-Johnson Syndrome / Q000473:pathology*