[Effect of several inhibitors of atmospheric metal corrosion (amines of the polymethylene series) on embryogenesis].
The influence of some polymethylene amines (inhibitors protecting metals from atmospheric corrosion) on the generative function in general and on the embryogenesis in particular was studied. Such inhibitors as MCDA-II (dicyclohexylamine salt dissolving in oil), HDA (dicyclohexylamine nitrate) and M-I (cyclohexylamine salt dissolving in oil) were investigated by intraorganic injection during the whole course of gestation (21 days), 2 and 4 months. The compounds in question were stated to possess a pronounced gonado- and embryotoxic effect depending on the dose and chemical composition of the substance. The least active was M-I inhibitor. Doses not affecting rat gonades were: for HDA--0.825 mg/kg, MCDA-II--4.7 mg/kg, M-I--34.9 mg/kg; their embryonic effects were 0.54, 2.35 and 349 mg/kg respectively.
D000818:Animals; D002452:Cell Count; D003514:Cyclohexylamines / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D047108:Embryonic Development; D005260:Female; D005313:Fetal Death / Q000139:chemically induced*; D007928:Lethal Dose 50; D008297:Male; D011247:Pregnancy; D051381:Rats; D013093:Spermatogonia; D013329:Structure-Activity Relationship; D013733:Testicular Diseases / Q000139:chemically induced / Q000473:pathology; D013737:Testis / Q000473:pathology
D003514:Cyclohexylamines
Osobennosti vliianiia nekotorykh ingibitorov atmosfernoĭ korrozii metallov (aminov polimetilenovogo riada) na émbriogenez.