title: [Effect of baxacor on the hemodynamics and contractile function of the myocardium in acute ischemia (an experimental study)].
abstract: The article discusses the results of experiments on 16 dogs in which acute myocardial ischemia was reproduced with intravenous infusion of baksacor and without the infusion of the drug; control experiments were also performed on an intact heart with baksacor infusion. Hemodynamics and myocardial contractility were studied throughout the entire experiment. It was found that baksacor had practically no effect on an intact heart. In acute ischemia the maximum effect of the drug was manifested on the 5th-25th minutes. An increase of the stroke volume and normalization of the rate of shortening of the contraction component were observed. An anti-arrhythmic effect of baksacor was noted.
mesh_terms: D000208:Acute Disease; D000818:Animals; D003327:Coronary Disease / Q000188:drug therapy* / Q000503:physiopathology; D004285:Dogs; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D011405:Propafenone / Q000031:analogs & derivatives; D011427:Propiophenones / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D011427:Propiophenones; C001162:etafenone; D011405:Propafenone
vernacular_title: Vliianie baksakora na gemodinamiku i sokratitel'nuiu funktsiiu miokarda pri ostroĭ ego ishemii (éksperimental'noe issledovanie).