Influence of pentacyanoferrate complexes on platelet aggregation.
To elucidate the structural constituents of sodium nitroprusside responsible for antiaggregating effects, comparative studies were done with pentacyanoferrates possessing ligands other than nitric oxid. Among the pentacyanoferrates tested, also the nitro and thionitro compounds possess considerable antiaggregating effects. The ammine and aquo compounds are nearly ineffective. These results support the assumption that the nitrosyl cation or its secondary product, nitrous acid, is responsible for the inhibition of aggregation.
D005292:Ferricyanides / Q000494:pharmacology*; D006801:Humans; D009574:Nitro Compounds / Q000494:pharmacology; D009599:Nitroprusside / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects*
D005292:Ferricyanides; D009574:Nitro Compounds; D009599:Nitroprusside