Sinus histiocytosis with massive lymphadenopathy and paraparesis: remission with chemotherapy. A case report.
A case of sinus histiocytosis with massive lymphadenopathy (SHML) in which cranial nerve function was impaired is described. Severe paraparesis due to an epidural block at the C2 and C5-T2 levels was also present. Treatment with cytotoxic agents resulted in a dramatic decrease in the size of the involved lymph nodes and disappearance of neurological symptomatology. A review of the literature revealed that, although the disease is benign in its clinical course, the process is not restricted to the lymph nodes. The case reported here is the second case in which the epidural space was affected.
D000293:Adolescent; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008206:Lymphatic Diseases / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D009333:Neck; D010243:Paralysis / Q000150:complications / Q000188:drug therapy*; D011239:Prednisolone / Q000627:therapeutic use*; D012075:Remission, Spontaneous; D014747:Vinblastine / Q000627:therapeutic use*
D014747:Vinblastine; D011239:Prednisolone