Learned taste aversions in children receiving chemotherapy.
Children with neoplastic diseases were offered an unusual ice cream before their drug treatments. Patients experiencing gastrointestinal toxicity due to the drugs were subsequently less likely to choose that ice cream again than controls. This suggests that taste aversions induced by drug-associated symptoms may contribute to the appetite loss experienced by cancer patients.
D000293:Adolescent; D000855:Anorexia / Q000139:chemically induced; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D001362:Avoidance Learning / Q000502:physiology*; D002648:Child; D002675:Child, Preschool; D003520:Cyclophosphamide / Q000009:adverse effects; D003561:Cytarabine / Q000009:adverse effects; D004064:Digestive System / Q000187:drug effects; D004317:Doxorubicin / Q000009:adverse effects; D005247:Feeding Behavior / Q000502:physiology; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D013649:Taste / Q000502:physiology; D014750:Vincristine / Q000009:adverse effects
D000970:Antineoplastic Agents; D003561:Cytarabine; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide