Stimulation of cell proliferation by histamine H2 receptors in dimethylhdrazine-induced adenocarcinomata.
Cell proliferation in dimethylhydrazine-induced colonic carcinomata was stimulated by histamine and by the histamine H2 receptor agonist dimaprit and inhibited by the histamine H2 receptor antagonists Metiamide and Cimetidine but not by the histamine H1 receptor antagonist Mepyramine. In contrast histamine had no effect on colonic crypt cell proliferation in normal or dimethylhydrazine-treated rats.
D000230:Adenocarcinoma / Q000139:chemically induced / Q000473:pathology*; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002927:Cimetidine / Q000494:pharmacology; D003106:Colon; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000473:pathology*; D004127:Dimethylhydrazines; D006632:Histamine / Q000494:pharmacology*; D007413:Intestinal Mucosa / Q000187:drug effects*; D008297:Male; D008785:Metiamide / Q000494:pharmacology; D011738:Pyrilamine / Q000494:pharmacology; D051381:Rats; D011968:Receptors, Histamine / Q000187:drug effects*; D011970:Receptors, Histamine H2 / Q000187:drug effects*; D013268:Stimulation, Chemical; D013890:Thiourea / Q000031:analogs & derivatives / Q000494:pharmacology
D004127:Dimethylhydrazines; D011968:Receptors, Histamine; D011970:Receptors, Histamine H2; D008785:Metiamide; D002927:Cimetidine; D006632:Histamine; D013890:Thiourea; D011738:Pyrilamine