The cholinergic influences on the oxytocin activity of the hypothalamus and neurohypophysis in long-term dehydrated male rats.
The cholinergic influences on the oxytocin activity of the hypothalamus and neurohypophysis in long-term dehydrated male rats. Acta Physiol. Pol., 1978, 29 (1): 17-25. Rats dehydrated up to 12 days were injected intraperitoneally with carbachol or atropine sulfate in daily doses of 20 microgram/100 g and 1.0 mg/100 g, respectively. In not dehydrated rats atropine increased the oxytocin activity of the hypothalamus and neurohypophysis; carbachol did not influence the oxytocin potency of the hypothalamus but augmented it in the neurohypophysis. During long-term dehydration both carbachol and atropine intensified the depletion of oxytocin in the hypothalamus as well as in the neurohypophysis.
D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D002217:Carbachol / Q000494:pharmacology*; D003681:Dehydration; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010121:Oxytocin / Q000378:metabolism*; D010904:Pituitary Gland, Posterior / Q000187:drug effects / Q000378:metabolism*; D051381:Rats
D010121:Oxytocin; D001285:Atropine; D002217:Carbachol