[Study report on the lack of interaction between mianserine and noradrenaline in man].
Tricyclic antidepressants are known to potentiate the increase in blood pressure caused by noradrenaline. Five depressive patients were given intravenous noradrenaline before and after 2--4 weeks of treatment with Org GB 94 (Tolvin). The dose of noradrenaline was increased until a rise of 30 mmHg in systolic blood pressure occurred. No evidence of interaction between Org GB94 and noradrenaline was found. The implications of this are discussed.
D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology; D003863:Depression / Q000188:drug therapy; D003984:Dibenzazepines / Q000494:pharmacology*; D004341:Drug Evaluation; D004347:Drug Interactions; D006801:Humans; D008803:Mianserin / Q000494:pharmacology*; D009638:Norepinephrine / Q000494:pharmacology*
D000929:Antidepressive Agents, Tricyclic; D003984:Dibenzazepines; D008803:Mianserin; D009638:Norepinephrine
Untersuchungsbericht über fehlende interaktionen zwischen Mianserin und Noradrenalin beim Menschen.