title: Differential effects of handling on exploration in male and female rats.
abstract: In this study, sex differences in the exploratory behavior of handled and nonhandled animals were measured under conditions of both high and low stimulus variation. The apparatus used was a hole-board, which provided an exploratory response independent of ambulation. Significant effects of handling were found: nonhandled animals decreased head-dipping over days whereas handled animals maintained a high rate. Sex differences were also observed: patterns of head-dipping for males and females differed over days depending on whether objects was present (high stimulus variation) or absent (low stimulus variation) under the hole-board; females also head-dipped for  longer durations than males when objects were present; further, males and females showed completely opposite patterns of exploration depending on handling treatment and on level of stimulus variation. We conclude that handling differentially affects males and females, particularly as level of stimulus variability changes.
mesh_terms: D000818:Animals; D003345:Corticosterone / Q000097:blood; D005106:Exploratory Behavior / Q000502:physiology; D005260:Female; D006234:Handling, Psychological; D008297:Male; D051379:Mice; D012737:Sex Factors
chemical_list: D003345:Corticosterone