[Low-molecular weight nuclear RNA in the lymphocytes of healthy persons and chronic lympholeukemia patients].
Low-polymer nuclear RNA (1) of lymphocytes was studied comparatively in healthy individuals and patients with lympholeukemia. In 7.5% polyacrylamid gel both in normal lymphocytes and their leukemic analogs 9 fractions were identified which possess similar electrophoretic mobility. The correlation of separate fractions 1 in pathological lymphocytes was shown to differ from that in lymphocytes of healthy donors. The study of the metabolic activity 1 indicated that one of the fractions (D) is metabolically inert under conditions of a 1-hour label, while in normal lymphocytes one fraction was revealed, whereas in chronic lympholeukemia--two fractions being recorded only by their radioactivity.
D002467:Cell Nucleus / Q000032:analysis; D003593:Cytoplasm / Q000032:analysis; D006801:Humans; D007945:Leukemia, Lymphoid / Q000097:blood*; D008214:Lymphocytes / Q000032:analysis*; D008970:Molecular Weight; D012313:RNA / Q000032:analysis*; D012334:RNA, Neoplasm / Q000032:analysis*
D012334:RNA, Neoplasm; D012313:RNA
Nizkomolekuliarnye iadernye RNK v limfotsitakh zdorovykh i bol'nykh khronicheskim limfoleĭkozom.