title: Comparative study of the effects of oral and i.m. atropine and hyoscine in volunteers.
abstract: The effects of equivalent doses of atropine and hyoscine following oral and i.m. administration were assessed on salivary secretion, heart rate, arterial pressure, body temperature, pupillary size, near-point of vision and sweat-gland activity. The ratio of oral to i.m. doses of atropine on heart rate and salivary secretion appears to be 2:1 and that of hyoscine on salivary secretion about 5-6:1. Following oral administration the effects on the eye are minimal even after the highest doses of the two drugs, while the decrease in salivation is adequate.
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001285:Atropine / Q000008:administration & dosage* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005123:Eye / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D012472:Salivation / Q000187:drug effects; D012601:Scopolamine / Q000008:administration & dosage* / Q000494:pharmacology; D013545:Sweat Glands / Q000187:drug effects; D013997:Time Factors
chemical_list: D001285:Atropine; D012601:Scopolamine