[Deliberate self-overdose with propranolol. Changes in serum levels (author's transl)].
Suicidal attempt using beta-blockers are rare. Overdose by the ingestion of a large number of tablets rarely exceeds the high therapeutic doses suggested for the treatment of certain resistant cases of hypertension. The case described is that of a 65-year-old patient who took 800 mg of propanolol. Observation of plama levels showed that the half-life propanolol in the case of overdose is prolonged: 8.6 hours in this case, with a maximum plasma level of 1536 ng/ml. Plasma renin activity levels were low during the phase of intoxication and showed evidence of a rebound effect at its end. Treatment is above all that of the circulatory insufficiency produced: isopropylnoradrenaline or glucagon. Indications for extra-renal dialysis should take into account knowledge concerning the pharmacokinetics of these drugs and their prolonged physiological action.
D000368:Aged; D005934:Glucagon / Q000627:therapeutic use; D006207:Half-Life; D006801:Humans; D008297:Male; D009638:Norepinephrine / Q000031:analogs & derivatives; D011433:Propranolol / Q000097:blood* / Q000378:metabolism / Q000506:poisoning*; D012083:Renin / Q000097:blood; D013406:Suicide, Attempted; D013997:Time Factors
D005934:Glucagon; D011433:Propranolol; D012083:Renin; D009638:Norepinephrine
Intoxication volontaire par le propranolol. Evolution des taux sériques.