Inhibition of the efflux of organic ions from renal cortical slices.
Cyanine 863 inhibited the efflux of tetraethylammonium ion from slices of rat or rabbit renal cortex while the efflux of p-aminohippuric acid was unaffected. Dinitrophenol increased the efflux rate of both the cation and anion. Cyanine also decreased the dinitrophenol-enhanced efflux of tetraethylammonium (TEA).
D000618:Aminohippuric Acids / Q000378:metabolism*; D000818:Animals; D004396:Coloring Agents / Q000494:pharmacology; D004140:Dinitrophenols / Q000494:pharmacology; D005260:Female; D007672:Kidney Cortex / Q000187:drug effects / Q000378:metabolism*; D011743:Pyrimidines / Q000494:pharmacology; D011806:Quinolinium Compounds / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D013757:Tetraethylammonium Compounds / Q000378:metabolism*
D000618:Aminohippuric Acids; D004396:Coloring Agents; D004140:Dinitrophenols; D011743:Pyrimidines; D011806:Quinolinium Compounds; D013757:Tetraethylammonium Compounds; C016855:cyanine 863