title: Cetocycline, tetracycline analog: in vitro studies of antimicrobial activity, serum binding, lipid solubility, and uptake by bacteria.
abstract: Cetocycline (formerly chelocardin or cetotetrine) is structurally related to the tetracyclines. It was found to be more active than tetracycline against many clinical isolates of aerobic gram-negative bacilli, but is less active against staphylococci, and has no activity against Pseudomonas. It is bactericidal against susceptible enteric gram-negative bacteria at concentrations two to four times higher than the minimal inhibiting concentrations. The drug is highly lipid soluble; more than 80% is bound to serum, and it is more avidly taken up by susceptible bacteria than tetracycline. A direct correlation between drug uptake and susceptibility of bacteria was not noted, except with a strain of Proteus vulgaris.
mesh_terms: D001419:Bacteria / Q000187:drug effects / Q000378:metabolism; D008055:Lipids; D012995:Solubility; D013754:Tetracyclines / Q000097:blood / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D008055:Lipids; D013754:Tetracyclines