[Bronchial asthma due to occupation allergy of immediate type (I) to platinum salts (author's transl)].
Occupational inhalation allergy (bronchial asthma, rhinitis, conjunctivitis), often in association with urticaria and Quincke oedema is common in platinum associated industry. It is due to sensitization against platinum chloride. The reaction mechanism corresponds to the immediate type (I) allergy as shown by clinical tests (skin tests), in virtro (histamine release from leucocytes) and in vivo investigations (passive cutaneous anaphylaxis in apes). The degree of sensitization is so high that test investigations in affected persons must be performed with care. For prick testing with platinum chloride (PtCl6)2- or (PtCl4)2- an initial concentration of 10(-9) g/ml is recommended. As an average of 60% of people working in the platinum industry fall ill with bronchial asthma more stringent protective occupational measures are suggested.
D000799:Angioedema / Q000139:chemically induced; D001249:Asthma / Q000139:chemically induced*; D003231:Conjunctivitis / Q000139:chemically induced; D004781:Environmental Exposure; D006801:Humans; D006969:Hypersensitivity, Immediate; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced*; D010984:Platinum / Q000009:adverse effects*; D006255:Rhinitis, Allergic, Seasonal / Q000139:chemically induced; D014581:Urticaria / Q000139:chemically induced
D010984:Platinum
Asthma bronchiale durch berufsbedingte Allergie vom Soforttyp gegen Platinsalze. Untersuchungen zur Immunpathologie und arbeitsmedizinische Problematik.