Intraocular penetration of topical clindamycin in rabbits.
Clindamycin is a recently developed, semisynthetic antibiotic whose spectrum of activity suggests a potential for the treatment of common ocular infections. The upake by various ocular tissues and serum in albino rabbits after topical administration of 0.2% clindamycin hydrochloride was studied. Therapeutic levels were achieved in the cornea, aqueous humor, and iris-ciliary body and persisted for two hours. Peak concentration occurred in the cornea within 15 minutes and in the aqueous humor and the iris-ciliary body at 30 minutes. Freezing of the tissue reduced active clindamycin levels in the cornea by a factor of 2 to 2 1/2 of those determined by fresh tissue analysis but had no apparent effect on aqueous humor and iris-ciliary body. There were, however, no detectable levels in the serum or vitreous humor.
D000287:Administration, Topical; D001082:Aqueous Humor / Q000378:metabolism; D001682:Biological Availability; D002924:Ciliary Body / Q000378:metabolism; D002981:Clindamycin / Q000008:administration & dosage / Q000378:metabolism*; D003315:Cornea / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005123:Eye / Q000378:metabolism*; D005615:Freezing; D007498:Iris / Q000378:metabolism; D013997:Time Factors
D002981:Clindamycin