[Effects of cycloheximide and chlorotetracycline on the activities of RNA-polymerases in mouse liver nuclei].
The activities of RNA-polymerases I and II in mouse liver nuclei isolated after injection of various poisons to mice were studied. An increased activity of RNA-polymerase I in the nuclei isolated from mouse liver after injection of the inhibitors of translation, i.e. cycloheximide and chlorotetracycline, was found. The activity of RNA-polymerase II remained unchanged. The inhibition of protein synthesis in mitochondria following the injection of chloramphenicol did not affect the activities of nuclear RNA-polymerases. The animal poisoning by carbon tetrachloride accompanied by a total decrease of the rates of protein and RNA synthesis in the liver decreased the activities of both RNA-polymerases, the activity of RNA-polymerase II being inhibited stronger as compared to that of RNA-polymerase I.
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000378:metabolism; D002467:Cell Nucleus / Q000201:enzymology*; D002701:Chloramphenicol / Q000494:pharmacology; D002751:Chlortetracycline / Q000494:pharmacology*; D003513:Cycloheximide / Q000494:pharmacology*; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D051379:Mice; D012318:RNA Polymerase I / Q000378:metabolism*; D012319:RNA Polymerase II / Q000378:metabolism*
D002701:Chloramphenicol; D003513:Cycloheximide; D012319:RNA Polymerase II; D012321:DNA-Directed RNA Polymerases; D012318:RNA Polymerase I; D002751:Chlortetracycline
Vliianie tsiklogeksimida i khlortetratsiklina na aktivnost' RNK-polimeraz v iadrakh lecheni myshei.