Site of respiratory reaction in allergic rats challenged via the airways.
Rats systemically sensitized to DNP-ovalbumin show a characteristic respiratory response to antigen challenge delivered via the airway. The slowing of expiratory air flow which occurs on aerosol challenge still occurs when the antigen is injected via a tracheostomy but not when it is delivered solely to the upper airways. Disodium cromoglycate administered via the tracheostomy 1 min before intratracheal antigen challenge reduces the respiratory response.
D000281:Administration, Intranasal; D000336:Aerosols; D000818:Animals; D000941:Antigens / Q000008:administration & dosage*; D007442:Intubation, Intratracheal; D010047:Ovalbumin / Q000276:immunology; D051381:Rats; D012137:Respiratory System / Q000276:immunology
D000336:Aerosols; D000941:Antigens; D010047:Ovalbumin