[Comparative study of the toxicity of poly G-poly C and poly I-poly C in different objects].
The poly(G).poly(C) complex has the same interferon-inducing and antiviral activity upon parenteral administration to white mice as poly(I).poly(C), but is considerably less toxic. Upon intravenous inoculation of poly(I).poly(C) to mice its LD50 is 15.8 mg/kg whereas poly(G).poly(C) is not toxic in doses up to 200 mg/kg. In rabbits inoculated with poly(I).ploy(C) intravenously its LD50 is 0.22 mg/kg, while poly(G).poly(C) is not toxic in doses of 1 mg/kg. Histological examinations of different organs of mice and rats revealed no pathomorphological changes after a single intravenous and intraperitoneal inoculation of poly(G).poly(C). It exerted no embryotoxic effect in mice in a dose of 5 mg/kg and was considerably less toxic than poly(I).poly(C) in continuous diploid cell cultures of human embryo lung cells.
D000818:Animals; D000998:Antiviral Agents; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D004338:Drug Combinations; D004622:Embryo, Mammalian / Q000187:drug effects; D005260:Female; D006801:Humans; D007369:Interferon Inducers; D007928:Lethal Dose 50; D051379:Mice; D008938:Mitosis / Q000187:drug effects; D011066:Poly C / Q000633:toxicity*; D011068:Poly G / Q000633:toxicity*; D011070:Poly I-C / Q000633:toxicity*; D011131:Polyribonucleotides / Q000633:toxicity*; D011247:Pregnancy
D000998:Antiviral Agents; D004338:Drug Combinations; D007369:Interferon Inducers; D011131:Polyribonucleotides; D011068:Poly G; D011066:Poly C; D011070:Poly I-C
Sravnitel'noe issledovanie toksichnosti poli(G).poli(Ts) i poli(I).poli(Ts) na razlichnykh ob'ektakh.