Are anticholinergic effects responsible for the heterogeneous quinidine-induced modifications of heart muscle refractoriness?
Vagal tone is responsible for the heterogeneous reactivity of atrial and ventricular contractile tissues to quinidine. Acetylcholine may make atrial cells more sensitive to the effects of quinidine.
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D004285:Dogs; D009200:Myocardial Contraction / Q000187:drug effects*; D011802:Quinidine / Q000494:pharmacology*; D014628:Vagotomy
D001285:Atropine; D011802:Quinidine; D000109:Acetylcholine