[Ultrastructural and functional features of the reversibility of sclerotic liver changes in rats treated with exogenous organ specific RNA].
Ultrastructural peculiarities of hepatocytes and Kupffer's cells in rats during the spontaneous reversibility of the experimental cirrhosis of the liver under the usual conditions and also under the influence of exogenous RNA, administered by different methods, were studied. The changes in cell ultrastructure proved to correlate with those of the quantitative indices of the protein synthesizing the liver function during the hepatic cirrhosis reversibility. A positive role of the RNA influence of short duration on the intracellular reparative hepatocytes regeneration, and a negative one in case of RNA influence of long duration was revealed. Participation in the resorption of collagen both of the parenchymal cells and of the stroma was shown.
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000150:complications; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D007728:Kupffer Cells / Q000648:ultrastructure; D008099:Liver / Q000378:metabolism / Q000648:ultrastructure*; D008106:Liver Cirrhosis, Experimental / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D008115:Liver Regeneration; D008297:Male; D009928:Organ Specificity; D010586:Phagocytes / Q000648:ultrastructure; D011506:Proteins / Q000378:metabolism; D012313:RNA / Q000627:therapeutic use*; D051381:Rats
D011506:Proteins; D012313:RNA
Ul'trastrukturnye i funktsional'nye osobennosti obratimosti skleroticheskikh izmeneniĭ pecheni krys pod vliianiem ékzogennoĭ organospetsificheskoĭ RNK.