[The effect of the polymeric quaternary ammonium salt,2,5-ionene on blood coagulation].
In modelling overdosages of the polymeric antagonist in cases of heparin neutralization the effect of 2.5-ionene on the blood coagulation in rabbits was considered during investigations in vivo. It is shown that even appreciable overdosages of 2.5-ionene are not attended by the effect of hypocoagulation. Shortening the plasma coagulation time according to the thromboplastic activity after Quick occurs through activation of the factor X proceeding against the background of falling activity of some other coagulation factors and comes as a result of excess 2.5-ionene in the blood. A reduced amount and lowering of the aggregation capacity of the thrombocytes are noted.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D001780:Blood Coagulation Tests; D005170:Factor X / Q000502:physiology; D006494:Heparin Antagonists / Q000008:administration & dosage; D010974:Platelet Aggregation / Q000187:drug effects; D000644:Quaternary Ammonium Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits
D006494:Heparin Antagonists; D000644:Quaternary Ammonium Compounds; D005170:Factor X
Bliianie chetvertichnoĭ ammoniinoĭ polimeroĭ soli 2,5-ionena na svertyvanie krovi.