The distribution and excretion of non-biodegradable anionic surfactants.
1. The metabolism of potassium 10-undecenyl [35S]sulphate and potassium 10-phenyldecyl [35S]sulphate was investigated in the rat. 2. The major route for elimination of radioactivity following potassium 10-undecenyl [35S]sulphate administration was urinary. With 10-phenyldecyl [35S]sulphate the major route of elimination was biliary. 3. Whole-body radioautography and isolated liver perfusion experiments established that both esters were concentrated in the liver, the major organ of metabolism. 4. Neither surfactant was degraded to short-chain anionic derivatives but both compounds were extensively metabolized.
D000818:Animals; D001646:Bile / Q000378:metabolism; D005260:Female; D005966:Glucuronidase / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D012737:Sex Factors; D013462:Sulfur Radioisotopes; D013501:Surface-Active Agents / Q000378:metabolism* / Q000652:urine; D013997:Time Factors
D013462:Sulfur Radioisotopes; D013501:Surface-Active Agents; D005966:Glucuronidase