Enzymatic changes in peripheral blood leukocytes in rats in subacute benzene vapours poisoning.
The activity of acid phosphatase (AcP), its intracellular distribution in peripheral blood lymphocytes and the activity of lysosomal isoenzyme of acid phosphatase (AcPL) in serum of rats exposed to benzene vapour in the concentration 27 000 mg/m3 for 6 hours daily through 10 consecutive days were investigated. The statistically significant fall in the number of lymphocytes affecting AcP-positive and AcP-negative lymphocytes, reduction in the percentage of granular lymphocytes and increase in the percentage of granular-diffusive and diffusive lymphocytes were found. The increase in the activity of AcPL in serum was statistically insignificant. According to the authors opinion the phenomenon observed results from a damage to lymphocytic lysosomes by benzene.
D000135:Acid Phosphatase / Q000097:blood*; D000818:Animals; D001554:Benzene / Q000506:poisoning*; D002452:Cell Count; D007527:Isoenzymes / Q000097:blood; D008214:Lymphocytes / Q000201:enzymology*; D008247:Lysosomes / Q000187:drug effects; D008297:Male; D051381:Rats
D007527:Isoenzymes; D000135:Acid Phosphatase; D001554:Benzene