The effect of secretin on bile production, splanchnohepatic hemodynamics and liver function in cats.
The effect of secretin on bile flow, biliary clearance of 14C-erythritol and bile composition was studied in fasting, chloralose anesthetized cats. Secretin (2 U.kg-1 . h-1) increased from values below the values above the erythritol clearance, which did not change significantly. It is therefore concluded that secretin altered ductular transfer of fluid from a net reabsorption to a net secretion of a bicarbonate rich fluid. Secretin did not affect the sphlanchno-hepatic hemodynamics or the overall function of the liver and Indomethacin did not significantly alter the response to secretin.
D000818:Animals; D001639:Bicarbonates / Q000378:metabolism; D001646:Bile / Q000187:drug effects*; D002415:Cats; D004573:Electrolytes / Q000378:metabolism; D004896:Erythritol / Q000378:metabolism; D005215:Fasting; D007213:Indomethacin / Q000494:pharmacology; D008099:Liver / Q000187:drug effects*; D008102:Liver Circulation / Q000187:drug effects*; D012633:Secretin / Q000494:pharmacology*
D001639:Bicarbonates; D004573:Electrolytes; D012633:Secretin; D004896:Erythritol; D007213:Indomethacin