Ball milling as a measure of crushing stength of granules.
When granules are milled in a ball mill, the size decrease follows a modification of Kick's law. The Briggsian decay constant, here denoted as the attritional crushing strength, shows correlation with the Harwood-Pilpel crushing strength. Both crushing strengths show a correlation with the amount of granulating agent (povidone) added to the granulation, i.e., the more povidone added, the harder the granule.
D008722:Methods; D011786:Quality Control; D013678:Technology, Pharmaceutical