On the chemical nature of the blood borne cardiotoxic material released from the feline small bowel in regional shock.
The cardiotoxic material released into blood from the feline small intestine during a 2 or 3 h regional shock period (inflow pressure to the small intestine 30--35 mmHg during a continuous activation of the regional sympathetic vasoconstrictor fibres at 6 Hz) has been analyzed with regard to three properties: 1. molecular mass determined by molecular filtrations; 2. solubility in a nonpolar solvent (ether); 3. heat stability by heating plasma to 80 degrees C for 30 min. The results obtained suggest that the cardiotoxic material consists of at least two heat stable fractions. One is water soluble with a molecular mass between 500 and 1 000 d and the other is lipid soluble with an unknown molecular mass.
D000320:Adrenergic Fibers / Q000502:physiology; D000818:Animals; D001681:Biological Assay; D001794:Blood Pressure; D002415:Cats; D004573:Electrolytes / Q000097:blood; D006321:Heart / Q000503:physiopathology*; D006358:Hot Temperature; D007419:Intestinal Secretions / Q000032:analysis*; D007421:Intestine, Small / Q000098:blood supply / Q000378:metabolism*; D010210:Papillary Muscles / Q000032:analysis; D012769:Shock / Q000503:physiopathology*; D012995:Solubility; D014118:Toxins, Biological / Q000032:analysis*; D014462:Ultrafiltration; D014661:Vasoconstriction
D004573:Electrolytes; D014118:Toxins, Biological