title: [Critical period in the work of the form-inducing apparatus of the lens in chick embryos, detected after chloramphenicol application].
abstract: The inhibitor of protein synthesis chloramphenicol (2 mg/egg) was applied to elucidate the critical period in the chicken lens development. Chloramphenicol injected before incubation and at 24, 30 and 48 h of incubation did not prevent the formation of parts in the lens-inducing apparatus (the optic vesicle, and the presumptive lens ectoderm), but the injection at the stage of 24--30 h of incubation resulted, in many survived for 5--7 days of incubation, in lack of the lens. Therefore, it is possible to speak about a disturbance in the activity of the inducing apparatus during the period of determination, or about a critical period of the lens development.
mesh_terms: D000367:Age Factors; D000818:Animals; D002642:Chick Embryo; D002701:Chloramphenicol / Q000494:pharmacology*; D004627:Embryonic Induction / Q000187:drug effects; D007908:Lens, Crystalline / Q000196:embryology*; D009024:Morphogenesis / Q000187:drug effects
chemical_list: D002701:Chloramphenicol
vernacular_title: Kriticheskiĭ period v rabote formoobrazovatel'nogo apparata khrustalika u zarodysheĭ tsyplenka, vyiavliaemyĭ pri deĭstvii khloramfenikola.