[The structure and antihypoxic action of alpha-dicarbonyl compounds and their derivatives].
The protective action in hypoxic hypoxia of 29 synthetized alpha-dicarbonyl compounds were studied. In this series of substances the natihypoxic activity was found to be most marked in drugs whose redox potential amounted to 0.15--0.3 V and which displayed a high dehydrating activity. Such compounds include isatin, its 3-anyl, 3-thiosemicarbation of ethyl either, isatin-1 of acetic acid and acenaphthequinone. Substitution is position 1 and 3 of isatin can lead to the formation of active substances, whereas substitution in position 2 usually reduces the antihypoxic activity.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D000860:Hypoxia / Q000188:drug therapy*; D007659:Ketones / Q000494:pharmacology* / Q000627:therapeutic use; D010084:Oxidation-Reduction; D051381:Rats; D013329:Structure-Activity Relationship
D007659:Ketones
Stroenie i antigipoksicheskaia aktivnostv al'fa-dikarbonil'nykh soedĭnenii i ikh proizvodnykh.