Deafness and biochemical imbalance after burns treatment with topical antibiotics in young children. Report of 6 cases.
Six children are described in whom deafness followed treatment of full thickness burns with topical antibiotic spray containing neomycin. 3 children developed hypocalcaemic tetany, and were shown to have a metabolic disorder involving hypocalcaemia, hypomagnesaemia, and hypokalaemia. The dangers of treating burns with topical ototoxic and nephrotoxic antibiotics are emphasised.
D000336:Aerosols; D002056:Burns / Q000188:drug therapy*; D002712:Chlorides / Q000097:blood; D003638:Deafness / Q000139:chemically induced*; D006801:Humans; D006996:Hypocalcemia / Q000139:chemically induced*; D007008:Hypokalemia / Q000139:chemically induced*; D007223:Infant; D008274:Magnesium / Q000097:blood*; D008297:Male; D009355:Neomycin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use
D000336:Aerosols; D002712:Chlorides; D009355:Neomycin; D008274:Magnesium