[Experimental experiences with intra-articular injections of the alpha-emitting radionuclide 224Ra (ThX) into the knee-joint of rats (author's transl)].
224Ra is used within the therapy of rheumatoid arthritis. The distribution of this radionuclide in the organism was investigated up to 7 days after incorporation in order to estimate a possible risk of late effects. In the autoradiographs we found strong blackenings at those bonesurfaces which faced the injected knee-joint hole. In addition the radionuclide was deposited in skeletal growth-zones similarly as after i.v. and i.p. injections. The dosimetric data (particularly of knee-joint and skeleton) were calculated and compared with those which occur after the therapy of ankylosing spondylitis using i.v. 224Ra injections.
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000532:radiotherapy; D001345:Autoradiography; D005260:Female; D007270:Injections, Intra-Articular; D007719:Knee Joint / Q000528:radiation effects*; D011829:Radiation Dosage; D011883:Radium / Q000008:administration & dosage* / Q000378:metabolism / Q000627:therapeutic use; D051381:Rats
D011883:Radium
Experimentelle Erfahrungen mit intraartikulären Injektionen des alpha-emittierenden Radionuklids Ra-224 (ThX) in das Kniegelenk von Ratten.