Effect of histamine H1- and H2-receptor blockade on canine gastric acid secretion.
In dogs with gastric fistulae and Heidenhain pouches, inhibition of histamine-stimulated gastric acid secretion by the histamine H2-receptor antagonist metiamide is not increased by the addition of a histamine H1-receptor antagonist (mepyramine maleate). Under the conditions of this study there is no evidence for the presence of histamine H1-receptor sites on the gastric parietal cell.
D000818:Animals; D004285:Dogs; D005750:Gastric Juice / Q000378:metabolism*; D008785:Metiamide / Q000494:pharmacology*; D011725:Pyridines / Q000494:pharmacology*; D011738:Pyrilamine / Q000494:pharmacology*; D011968:Receptors, Histamine / Q000502:physiology*; D011969:Receptors, Histamine H1 / Q000502:physiology*; D012636:Secretory Rate; D013270:Stomach / Q000187:drug effects*; D013890:Thiourea / Q000031:analogs & derivatives*
D011725:Pyridines; D011968:Receptors, Histamine; D011969:Receptors, Histamine H1; D008785:Metiamide; D013890:Thiourea; D011738:Pyrilamine