Is GABA involved in analgesia?
The effect of morphine and naloxone on gamma-aminobutyric acid (GABA) concentration in discrete areas of the rat brain has been studied. Neither morphine nor naloxone had a significant effect on regional steady-state concentrations of GABA. The results have been discussed with respect to the role of GABA in pain and analgesia.
D000613:Aminobutyrates / Q000502:physiology*; D000698:Analgesia; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D008297:Male; D009020:Morphine / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D000613:Aminobutyrates; D009270:Naloxone; D005680:gamma-Aminobutyric Acid; D009020:Morphine