Effects of petroleum hydrocarbon solvents on alkaline phosphatase of rats.
After administration of benzene, gasoline, IOMEX or petroleum ether, liver alkaline phosphatase showed over 200% increase in activity whereas kidney alkaline phosphatase activity was depressed by 50%. The pattern of separation of isoenzymes of alkaline phosphatase in liver, kidney and serum indicated involvement of one of the isoenzymes. A simple method of detecting the incipent toxicity is described.
D000469:Alkaline Phosphatase / Q000097:blood / Q000378:metabolism*; D000818:Animals; D004591:Electrophoresis, Polyacrylamide Gel; D006838:Hydrocarbons / Q000494:pharmacology*; D007527:Isoenzymes / Q000378:metabolism; D007668:Kidney / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D008297:Male; D010578:Petroleum; D051381:Rats; D012997:Solvents / Q000494:pharmacology
D006838:Hydrocarbons; D007527:Isoenzymes; D010578:Petroleum; D012997:Solvents; D000469:Alkaline Phosphatase