Stimulation of non-parietal cell secretion in canine Heidenhain pouches by 16,16-dimethyl prostaglandin E2.
The permeability effects of topical and intravenous prostaglandin E2 (PGE2) and 16,16-dimethyl prostaglandin E2 (16DM) were studied in canine Heidenhain pouches using an acid-free perfusate, and changes in volume and HCO-3 content of the perfusate were measured. Topical and intravenous 16DM increased the apparent flux of Na+ and Cl-, and stimulated the secretion of fluid containing HCO-3. 16DM stimulates non-parietal cell secretion and therefore the movement of Na+ cannot be interpreted as passive flux in response to changes in permeability.
D000287:Administration, Topical; D000818:Animals; D001639:Bicarbonates / Q000378:metabolism; D002463:Cell Membrane Permeability / Q000187:drug effects; D002712:Chlorides / Q000378:metabolism; D004285:Dogs; D005260:Female; D005745:Gastric Acidity Determination; D005753:Gastric Mucosa / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D007263:Infusions, Parenteral; D010477:Perfusion; D011458:Prostaglandins E / Q000008:administration & dosage / Q000494:pharmacology*; D011459:Prostaglandins E, Synthetic / Q000008:administration & dosage / Q000494:pharmacology*; D012964:Sodium / Q000378:metabolism; D013270:Stomach / Q000502:physiology*; D014882:Water-Electrolyte Balance / Q000187:drug effects
D001639:Bicarbonates; D002712:Chlorides; D011458:Prostaglandins E; D011459:Prostaglandins E, Synthetic; D012964:Sodium