Pyridinium- and quinolinium-2-dithioacetic acid zwitterions: antiradiation and anticancer activities.
Pyridinium-, quinolinium-, and one pyrimidinium-2-dithioacetic acid zwitterions were prepared by condensation of the N-methyl heterocyclic anhydro bases with carbon disulfide. Reaction of the 2-methylpyridine methiodide anhydro base with carbon disulfide resulted in replacement of the 2-methyl group to give the 1-methylpyridinium-2-dithioacetic acid zwitterion. The 1,6-dimethylquinolinium-2-dithioacetic acid zwitterion showed appreciable anticancer activity against P-388 lymphocytic leukemia in mice, but the other zwitterions tested showed no activity. No antiradiation activity was found for 1-methyl-pyridinium-2-dithioacetic acid zwitterion.
D000085:Acetates / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D000962:Antimalarials; D000970:Antineoplastic Agents / Q000138:chemical synthesis; D007942:Leukemia, Experimental / Q000188:drug therapy; D051379:Mice; D011726:Pyridinium Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D011743:Pyrimidines / Q000138:chemical synthesis / Q000494:pharmacology; D011806:Quinolinium Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D011837:Radiation-Protective Agents
D000085:Acetates; D000962:Antimalarials; D000970:Antineoplastic Agents; D011726:Pyridinium Compounds; D011743:Pyrimidines; D011806:Quinolinium Compounds; D011837:Radiation-Protective Agents