Influence of protein deficiency on the inhibition of hepatic microsomal detoxication by methyl mercury in two rat strains.
N- and C-oxygenation of N,N-dimethylaniline was studied in liver microsomes from 2 rat strains (Wistar, Strain R and Sprague-Dawley) subjected to protein deprivation and methyl mercury pretreatment, separately and in combination. A striking interstrain difference was observed. Strain R microsomes from 2 rat strains (Wistar, Strain R and Sprague-Dawley) subjected to tion, but little effect after methyl mercury pretreatment. With Sprague-Dawley microsomes, C-oxygenation was slightly reduced after both treatments. N-oxygenation was little affected in either strain. Methyl mercury treatment of protein deprived rats strongly inhibited C-oxygenation in microsomes from both strains, with N-oxygenation being unaffected in strain R microsomes whereas markedly reduced in microsomes from Sprague-Dawley.
D000814:Aniline Compounds / Q000378:metabolism; D000818:Animals; D001711:Biotransformation; D004032:Diet; D066298:In Vitro Techniques; D008658:Inactivation, Metabolic; D008297:Male; D008767:Methylmercury Compounds / Q000494:pharmacology*; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D010084:Oxidation-Reduction; D011488:Protein Deficiency / Q000378:metabolism*; D051381:Rats
D000814:Aniline Compounds; D008767:Methylmercury Compounds