Cardiovascular and metabolic actions of an adenosine analogue (2'3'-o-methoxy-ethyliden-adenosine-5'-ethylcarboxamide) in the conscious dog.
The haemodynamic and metabolic actions of 2'3'-o-methoxyethyliden-adenosine-5'-ethylcarboxamide (744-98) were investigated in conscious dogs after i.v. and oral administration. 744-98 led to a marked dose-dependent increase in coronary blood flow, together with a slight increase in renal blood flow. In the standing position high doses of the drug revealed an adenosine-like negative chronotropic action, together with marked hypotension. Metabolic effects were observed with the higher coronary-active doses only. The increase in arterial glucose and decrease in free fatty acid levels are considered to be caused by a glucagon-releasing and adenosine-like action of 744-98. The haemodynamic and metabolic changes were observed both after i.v. and oral administration, showing a ratio of approximately 3:1 in favour of the parenteral route.
D000241:Adenosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003326:Coronary Circulation / Q000187:drug effects; D004285:Dogs; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D007668:Kidney / Q000098:blood supply; D007773:Lactates / Q000097:blood; D011188:Potassium / Q000097:blood; D012039:Regional Blood Flow / Q000187:drug effects
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007773:Lactates; D000241:Adenosine; D011188:Potassium