Antitubercular 2,8-bis(alkylaminomethyl)phenazines.
The preparation and antitubercular properties of a series of 2,8-bis(alkylaminomethyl)phenazines are described. These compounds all inhibited the growth of Mycobacterium smegmatis ATCC 607 in vitro. 2,8-Bis(dibutylaminomethyl)phenazine (5c) was also active against a lethal Mycobacterium tuberculosis H37Rv infection in mice.
D000818:Animals; D000995:Antitubercular Agents / Q000138:chemical synthesis*; D051379:Mice; D008826:Microbial Sensitivity Tests; D009161:Mycobacterium / Q000187:drug effects; D010619:Phenazines / Q000138:chemical synthesis* / Q000494:pharmacology
D000995:Antitubercular Agents; D010619:Phenazines