title: Effect of dexamethasone on protein extravasation in the brain in acute hypertension induced by amphetamine.
abstract: Amphetamine productes protein leakage in the brain when given to rats under nitrous oxide anesthesia. The blood-brain barrier dysfunction is caused by the combined effect of blood pressure increase and vasodilatation. In the present experiments pretreatment with dexamethasone, 2 mg.kg-1, diminished the amphetamine-induced extravasation of Evans blue albumin and 125IHSA in the rats' brain. Possible explanations to the effect of dexamethasone on cerebrovascular permeability are discussed.
mesh_terms: D000208:Acute Disease; D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D001798:Blood Proteins / Q000378:metabolism*; D001812:Blood-Brain Barrier / Q000187:drug effects*; D003907:Dexamethasone / Q000494:pharmacology*; D006973:Hypertension / Q000139:chemically induced / Q000378:metabolism*; D008297:Male; D051381:Rats; D012709:Serum Albumin / Q000378:metabolism
chemical_list: D001798:Blood Proteins; D012709:Serum Albumin; D003907:Dexamethasone; D000661:Amphetamine