An intravenous 133Xe method for measuring regional distribution of placental blood flow.
A new method for measuring regional distribution of placental blood flow is presented. After 2-5 mCi of 133Xe saline has been injected intravenously, the counts over the placenta are registered with a scintillation camera interfaced with a digital data storage and television readout system. Using "area of interest" technique, time activity curves are obtained for different regions. Analysis of the curves is based on two-exponential curve fitting. In normal pregnancy the mean intervillous flow in 16 healthy women was 125 ml/min/100 ml and myometrial flow 17 ml/min/100 g. The intervillous flow in the central part of the placenta was 55% higher than in the marginal parts. The myometrial flow in the placental area was nearly the same as outside the placenta.
D000293:Adolescent; D000328:Adult; D003201:Computers; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D010920:Placenta / Q000098:blood supply*; D011247:Pregnancy; D012039:Regional Blood Flow; D012588:Scintillation Counting; D012965:Sodium Chloride / Q000008:administration & dosage; D014980:Xenon Radioisotopes / Q000008:administration & dosage
D014980:Xenon Radioisotopes; D012965:Sodium Chloride