Phenoxybenzamine in neurogenic bladder dysfunction after spinal cord injury. II. Autonomic dysreflexia.
Phenoxybenzamine blockade of the alpha receptor site can abolish the vascular and internal sphincter responses in patients with chronic recurrent autonomic dysreflexia associated with bladder filling or contraction. The life-threatening hypertensive response is suppressed by this medication. Therefore, the drug is a beneficial adjunct in the pharmacologic management of autonomic dysreflexia. When the drug is used patients can be maintained free of a catheter. The drug had no serious side effects at the dose regimen used. One particularly significant advantage is its long duration of action--patients occasionally can skip doses of medication and not suffer acute symptoms.
D001341:Autonomic Nervous System; D002908:Chronic Disease; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008297:Male; D009422:Nervous System Diseases / Q000188:drug therapy / Q000209:etiology; D010643:Phenoxybenzamine / Q000627:therapeutic use*; D012021:Reflex, Abnormal / Q000188:drug therapy / Q000209:etiology; D013119:Spinal Cord Injuries / Q000150:complications*; D013546:Sweating; D001750:Urinary Bladder, Neurogenic / Q000188:drug therapy / Q000209:etiology
D010643:Phenoxybenzamine