Childhood embryonal carcinoma of testis, report of two unusual cases, and the implication on clinical management.
Primary testicular neoplasms are not common childhood tumors, comprising about 1% of all childhood malignancies [1]. Embryonal carcinoma is the most common childhood testicular neoplasm. It has been described in a variety of histologic variants as embryonal carcinoma of infancy, orchioblastoma, yolk sac tumor, endodermal sinus tumor, Teilum tumor, and adenocarcinoma with clear cells. Because of the rarity of the tumor, there is no general concensus concerning the management. Recently we encountered two children with embryonal carcinoma of testis who had rather unusual clinical courses. We believe that a report of these cases may contribute to further design of the most suitable therapeutic regimen.
D002369:Castration; D002675:Child, Preschool; D002699:Chlorambucil / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D003609:Dactinomycin / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D008175:Lung Neoplasms / Q000628:therapy; D008297:Male; D008466:Mechlorethamine / Q000627:therapeutic use; D009362:Neoplasm Metastasis; D011879:Radiotherapy Dosage; D013724:Teratoma / Q000473:pathology / Q000628:therapy*; D013736:Testicular Neoplasms / Q000473:pathology / Q000628:therapy*; D013737:Testis / Q000473:pathology; D014750:Vincristine / Q000627:therapeutic use
D002699:Chlorambucil; D003609:Dactinomycin; D008466:Mechlorethamine; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide