Effect of histamine methylation inhibitors on entry of 14C-histamine into brain.
Pretreatment of mice, rats and guinea pigs with inhibitors of histamine methylation, followed by systemic injection of 14C-histamine, results in a significant increase in brain 14C-histamine relative to controls. It is suggested that the histamine methylating enzyme participates in the blood-brain barrier to histamine.
D000655:Amodiaquine / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D003864:Depression, Chemical; D005260:Female; D006146:Guanidines / Q000494:pharmacology; D006632:Histamine / Q000378:metabolism*; D008297:Male; D008745:Methylation; D008761:Methylhistamines / Q000494:pharmacology; D051381:Rats
D006146:Guanidines; D008761:Methylhistamines; D000655:Amodiaquine; D006632:Histamine