Photochemotherapy of psoriasis.
Orally administered 8-methoxypsoralen followed by irradiation with longwave ultraviolet light (UVA, 320-400 nm, maximum 365 nm) resulted in 90-100% clearing in 24 of 26 psoriasis patients. Recurrence could be prevented by maintenance treatment. The treatment was tolerated well; no serious side effects were observed. A moderate increase of serum transaminase values was observed in 6 patients; in 5, these values became normal in a short time. The connection between these enzyme increases and the treatment is uncertain. At completion of the treatment the skin is universally, evenly hyperpigmented-a side effect considered positive by the patients.
D005260:Female; D006801:Humans; D008730:Methoxsalen / Q000627:therapeutic use; D010778:Photochemotherapy; D011247:Pregnancy; D011565:Psoriasis / Q000188:drug therapy*; D012008:Recurrence; D013997:Time Factors
D008730:Methoxsalen