title: Continuous intravenous deferoxamine infusion. Treatment of secondary hemochromatosis in adults.
abstract: Adult patients with chronic iron overload were given oral ascorbic acid and continuous intravenous infusions of deferoxamine mesylate. The dosage of deferoxamine mesylate was altered every 48 hours from 1 g/sq m/24 hr to 2 or 4 g/sq m/24 hr. The average iron mobilization was 55.6 mg per day at the 1 g/sq m/24 hr dosage level, 78.6 mg every 24 hours at the 2 g/sq m/24 hr dosage level, and 90.1 mg every 24 hours at the 4 g/sq m/24 hr dosage level. Iron mobilization was undiminished when successive 14-day courses of deferoxamine separated by six-week intervals were administered.
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000627:therapeutic use; D003676:Deferoxamine / Q000008:administration & dosage*; D005260:Female; D006432:Hemochromatosis / Q000188:drug therapy*; D006801:Humans; D007263:Infusions, Parenteral; D007501:Iron / Q000652:urine; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D007501:Iron; D003676:Deferoxamine; D001205:Ascorbic Acid