Synthetic fragment of human growth hormone with hyperglycemic properties: residues 44-77.
Peptides homologous to Cys53 44-77 and Cys53 52-77 of the human growth hormone molecule were prepared by solid-phase synthesis and tested by our acute glucose tolerance test in ob/ob mice. Peptide 44-77, as either the Acm-Cys53 or Cam-Cys53 derivative, adversely affects glucose tolerance at doses of 100 to 150 nmol. Peptide 52-77 is nonhyperglycemic. Other diabetogenic properties are being tested.
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D001681:Biological Assay; D001786:Blood Glucose / Q000378:metabolism; D013006:Growth Hormone; D006801:Humans; D006943:Hyperglycemia / Q000139:chemically induced; D051379:Mice; D008820:Mice, Obese; D010446:Peptide Fragments
D000596:Amino Acids; D001786:Blood Glucose; D010446:Peptide Fragments; D013006:Growth Hormone