[Anabolic action of flavonoids].
Flavonoids robinin and hyperin lengthen the average survival time of albino mice subjected to bilateral nephrectomy when introduced to the animals intraperitoneally in different doses. The effect of the study substances is inferior to that of dianabol with EU20 of robinin amounting to 82 mg/kg, of hyperin--88 mg/kg and that of dianabol--4.2 mg/kg. The methioned agents and also flavonoid lespedine enlarge the body mass and that of the musculus levator ani in growing castrated rats, when introduced by the intra peritoneal route in a dose of 100 mg/kg. Flavonoid robinin produces the greatest anabolic effect in tests set up both on mice and rats. The data obtained allow the spectrum of the biological action of flavonoids to be extended to some of their positive influence on the catabolic-anabolic processes.
D045930:Anabolic Agents / Q000494:pharmacology; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002369:Castration; D004305:Dose-Response Relationship, Drug; D005260:Female; D005419:Flavonoids / Q000494:pharmacology*; D006128:Growth / Q000187:drug effects; D008297:Male; D008660:Metabolism / Q000187:drug effects*; D009132:Muscles / Q000187:drug effects; D009392:Nephrectomy; D051381:Rats
D045930:Anabolic Agents; D005419:Flavonoids
Ob anaboliziruiushchem deĭstvii flavonoidov.