title: Towards a quantitative understanding of the epidemiology of Keystone virus in the eastern United States.
abstract: The implications of the Keystone virus--Aedes atlanticus transmission cycle are explored in the context of a quantitative model. Among the variables considered are the vertical transmission rate, the effect of the virus upon vector fertility and survival, vector densities and distributions, the proportion susceptible in the vertebrate population, the attractiveness of different vertebrates to the vector and vector survival rates. The logical relationships between these several variables are explored. It is concluded that the current view of Keystone virus maintenance is quantitatively feasible, and that certain predictions may be made as to the magnitude of several parameters which have not yet been measured. Such predictions allow direct testing of the model. The general structure of the model is such that it may prove useful in describing the epidemiology of other vector-borne infections in which vertical transmission is essential for infection maintenance at certain periods of the year.
mesh_terms: D000330:Aedes / Q000382:microbiology*; D000818:Animals; D002141:Encephalitis Virus, California; D004668:Encephalitis Viruses; D004671:Encephalitis, Arbovirus / Q000635:transmission*; D004670:Encephalitis, California / Q000453:epidemiology / Q000635:transmission*; D005247:Feeding Behavior; D006801:Humans; D007303:Insect Vectors; D008954:Models, Biological; D011336:Probability; D014481:United States