Snake venoms. The amino-acid sequence of trypsin inhibitor E of Dendroaspis polylepis polylepis (Black Mamba) venom.
Trypsin inhibitor E from black mamba venom comprises 59 amino acid residues in a single polypeptide chain, cross-linked by three intrachain disulphide bridges. The complete primary structure of inhibitor E was elucidated. The sequence is homologous with trypsin inhibitors from different sources. Unique among this homologous series of proteinase inhibitors, inhibitor E has an affinity for transition metal ions, exemplified here by Cu2 and Co2+.
D000595:Amino Acid Sequence; D002413:Cations, Divalent; D003035:Cobalt / Q000378:metabolism; D003300:Copper / Q000378:metabolism; D004220:Disulfides; D004546:Elapid Venoms / Q000032:analysis*; D010084:Oxidation-Reduction; D014361:Trypsin Inhibitors / Q000378:metabolism
D002413:Cations, Divalent; D004220:Disulfides; D004546:Elapid Venoms; D014361:Trypsin Inhibitors; D003035:Cobalt; D003300:Copper