title: Synthesis and hypotensive activity of a series of 2-substituted 5,6-dimethoxyindazoles.
abstract: The synthesis and hypotensive activity in the dog of a series of 2-substituted 5,6-dimethoxyindazoles are reported. Structure-activity relationships for this class of compounds are discussed. Indazoles containing the diethylaminoethyl, 3-pyridyl, and hydroxyethyl functions in the 2-position were the most effective in lowering blood pressure for the longest times (greater than 270 min).
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004285:Dogs; D007191:Indazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D011720:Pyrazoles / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D007191:Indazoles; D011720:Pyrazoles