[Experimental results from preoperative irradiation of renal adenocarcinoma (author's transl)].
Tissue samples were taken from the surgical preparations of 25 renal adenocarcinomas immediately after the operation, and cells were cultured. Between two and six weeks, the number of colonies per 10(6) sowed viable cells (not stainable with eosin) was determined. Eleven patients had not undergone preparatory treatment before operation, in three cases the branches of the renal artery were embolized, and eleven patients had been exposed to 800 up to 1600 rd TD delivered by 2 or 4 fractions in the course of two days prior to surgical treatment. Tumors without pretreatment or with preoperative embolization grew 32.6 and 41.7 colonies, respectively, per 10(6) viable cells, whereas the average yield from three tumors irradiated with a focal dose of 800 to 1100 rd was reduced to 7.1 colonies per 10(6) viable cells and in eight tumors exposed to a focal dose of 1200 or 1600 rd, even to zero. Therapeutical consequences are discussed.
D000230:Adenocarcinoma / Q000532:radiotherapy* / Q000601:surgery; D000368:Aged; D046508:Culture Techniques; D004621:Embolization, Therapeutic; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care; D011879:Radiotherapy Dosage
Experimentelle Ergebnisse der präoperativen Bestrahlung des renalen Adenokarzinoms.