Correlations between the genetic control of natural and oxazolone-induced antibody production.
Nonimmune sera of inbred and H-2 congenic mouse strains contain natural antibodies of the IgM type reacting with 4-(ethoxymethylene)-2-phenyloxazolin-5-one (oxazolone). The genetic regulation of the level of natural and induced antibodies to oxazolone was compared. High natural antibody-producing ability was inherited recessively, while high oxazolone-induced IgM antibody formation was dominant in F1 animals. Studies on nude mice demonstrated that T cells do not affect the natural antibody level, but were required for induced antibody production. Breeding studies and linkage analysis revealed multigenic control and a significant role of allotype-linked genes in both cases. Furthermore, the influence of H-2 linked genes on induced primary IgM antibody production was demonstrated.
D000818:Animals; D000906:Antibodies / Q000235:genetics*; D000917:Antibody Formation; D008040:Genetic Linkage; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008819:Mice, Nude; D010080:Oxazoles / Q000494:pharmacology*; D010081:Oxazolone / Q000276:immunology / Q000494:pharmacology*
D000906:Antibodies; D010080:Oxazoles; D010081:Oxazolone