Prevention of peritoneal adhesions by the combined use of spongostan and 32% dextran 70: an experimental study in pigs.
Twenty female pigs underwent laparotomy during which transection of both uterine horns and wedge resection of both ovaries were performed with a standard technique. Following the injuries a mixture of Spongostan and 32% dextran 70 was applied only to the lesions on the right side. Three weeks after surgery another laparotomy was performed and the degree of adhesion formation was recorded. A marked reduction in degree and extent of adhesions was observed on the treated side as compared with the control side. The possible advantages of a compound that can be applied locally and has hemostatic properties as well are discussed.
D000287:Administration, Topical; D000818:Animals; D003911:Dextrans / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005781:Gelatin Sponge, Absorbable / Q000008:administration & dosage / Q000627:therapeutic use*; D010053:Ovary / Q000601:surgery; D010537:Peritoneum; D011183:Postoperative Complications / Q000517:prevention & control*; D013552:Swine; D000267:Tissue Adhesions; D014599:Uterus / Q000601:surgery
D003911:Dextrans