Effect of cimetidine, histamine H2 receptor antagonist, in the prevention of experimental stress ulcer in the rat.
The protective effect of cimetidine on gastric mucosal lesions in the rat was investigated. Through prophylactic administration of 3x 25 7g/kh body weight for 24 just prior to the test period, the incidence rate of lesions, as well as upper gastro-intestinal haemorrhage was highly significantly reduced.
D000818:Animals; D002927:Cimetidine / Q000627:therapeutic use*; D005753:Gastric Mucosa / Q000187:drug effects; D006146:Guanidines / Q000627:therapeutic use*; D008297:Male; D010438:Peptic Ulcer Hemorrhage / Q000517:prevention & control; D051381:Rats; D013276:Stomach Ulcer / Q000209:etiology / Q000517:prevention & control*; D013312:Stress, Physiological
D006146:Guanidines; D002927:Cimetidine