Cephalothin induced neutropenia during the treatment of bacterial endocarditis.
The occurrence of cephalothin induced neutropenia in 3 patients with infective endocarditis is described. In each patient, withdrawal of cephalothin was followed by rapid haematological recovery. It is apparent that granulocytopenia may frequently occur in patients receiving prolonged, high dose, intravenous cephalothin for the treatment of bacterial endocarditis.
D000328:Adult; D000380:Agranulocytosis / Q000139:chemically induced*; D002512:Cephalothin / Q000009:adverse effects*; D002675:Child, Preschool; D004697:Endocarditis, Bacterial / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D009503:Neutropenia / Q000139:chemically induced*; D013290:Streptococcal Infections / Q000188:drug therapy
D002512:Cephalothin