Induction of lysinuria in the rat by two para-substituted guanidinophenylalanines.
1. p-Guanidino- and p-guanidinomethyl-phenylalanine increase the renal excretion of lysine especially and, to some extent, cystine in the phenylalanine-loaded rat. The methyl derivative is the more effective. 2. The lysinuria is dose-dependent, reversible, pronounced when the intravenous infusion of analogue exceeds 10 mumol min-1 kg-1 and does not appear to be secondary to changes in urine flow or sodium excretion. 3. A mechanism for induced basic amino-aciduria conditions is suggested.
D000596:Amino Acids / Q000652:urine; D000818:Animals; D005260:Female; D006146:Guanidines / Q000494:pharmacology; D008239:Lysine / Q000652:urine*; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats
D000596:Amino Acids; D006146:Guanidines; D010649:Phenylalanine; D008239:Lysine