The pathogenesis of myasthenia gravis.
The identification and purification of the acetylcholine receptor molecule has permitted a major advance in understanding the pathogenesis of Myasthenia gravis. The author explains the central role of the receptor and its connections with the main features of the disease. He gives a description of the pathogenic mechanisms involved.
D000109:Acetylcholine / Q000276:immunology*; D000936:Antigen-Antibody Complex; D001323:Autoantibodies / Q000096:biosynthesis*; D006801:Humans; D009157:Myasthenia Gravis / Q000276:immunology*; D009469:Neuromuscular Junction / Q000032:analysis; D011950:Receptors, Cholinergic / Q000032:analysis / Q000276:immunology*
D000936:Antigen-Antibody Complex; D001323:Autoantibodies; D011950:Receptors, Cholinergic; D000109:Acetylcholine