Failure of lysine-acetylsalicylate and phenylbutazone to affect gastrin secretion in healthy adults.
The effect of acute parenteral and chronic oral administration of lysine-acetylsalicylate and phenylbutazone on fasting and meal-stimulated serum gastrin levels was investigated in healthy volunteers. No significant changes in gastrin secretion were induced by any treatment. The results confirm and extend previous observations suggesting that the ulcerogenic properties of salicylates and phenylbutazone are not related to increased gastrin secretion.
D000284:Administration, Oral; D001241:Aspirin / Q000008:administration & dosage / Q000494:pharmacology*; D005755:Gastrins / Q000378:metabolism*; D006801:Humans; D007263:Infusions, Parenteral; D008239:Lysine / Q000008:administration & dosage / Q000494:pharmacology*; D010653:Phenylbutazone / Q000008:administration & dosage / Q000494:pharmacology*
D005755:Gastrins; D010653:Phenylbutazone; D008239:Lysine; D001241:Aspirin