Nitrofurantoin damages DNA of human cells.
Nitrofurantoin causes damage to DNA of cultured diploid human fibroblasts. As a consequence DNA synthesis is blocked. The damage is removed by the normal enzymatic DNA repair system. Xeroderma pigmentosum fibroblasts which are defective in the excision endonuclease fail to repair nitrofurantoin-caused lesions.
D004247:DNA / Q000378:metabolism*; D004260:DNA Repair; D004269:DNA, Bacterial / Q000096:biosynthesis; D005347:Fibroblasts / Q000187:drug effects*; D006801:Humans; D009582:Nitrofurantoin / Q000009:adverse effects*; D012333:RNA, Messenger / Q000096:biosynthesis; D014983:Xeroderma Pigmentosum / Q000378:metabolism
D004269:DNA, Bacterial; D012333:RNA, Messenger; D004247:DNA; D009582:Nitrofurantoin