Effects of oestrogen and progesterone on rat pineal N-acetyl transferase activity and melatonin production.
We have extended previous studies on pineal beta-receptors to include effects of oestradiol or PMSG treatment in the immature female rat. Neither manipulation has any effect on norepinephrine-induced N-acetyl transferase (NAT) activity in vitro. In the adult ovariectomised rat oestrogen/progesterone priming exerts a small sensitising effect to beta-stimulation with isoproterenol. Progesterone alone, in vitro, inhibits the release of melatonin from pineals of adult ovariectomised rats.
D000123:Acetyltransferases / Q000378:metabolism*; D000818:Animals; D002369:Castration; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D006064:Gonadotropins, Equine / Q000494:pharmacology; D007545:Isoproterenol / Q000494:pharmacology; D008550:Melatonin / Q000096:biosynthesis*; D009638:Norepinephrine / Q000494:pharmacology; D010870:Pineal Gland / Q000187:drug effects / Q000201:enzymology*; D011374:Progesterone / Q000494:pharmacology*; D051381:Rats
D006064:Gonadotropins, Equine; D011374:Progesterone; D004958:Estradiol; D000123:Acetyltransferases; D008550:Melatonin; D007545:Isoproterenol; D009638:Norepinephrine