[Studies on the genetics of otosclerosis (author's transl)].
101 families with confirmed otosclerosis were investigated, and after correction for age an incidence was found of otosclerosis of 29.5% amongst the parents, 17.9% amongst the siblings and 8.8% amongst offspring. The statistical data for otosclerosis published to date were treated similarly giving together with our own as large a collection as possible. From this the risk of repeat occurrence of otosclerosis could be calculated to 10% in the brothers and 20% in the sisters of otosclerotic patients. The risk rates of occurrence for their children are the same. These data are intended for use in the genetic counseling of this disorder.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D005817:Genetic Counseling; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D010040:Otosclerosis / Q000175:diagnosis / Q000235:genetics*; D012737:Sex Factors; D014636:Valsalva Maneuver / Q000379:methods
Untersuchungen zur Genetik der Otosklerose.