Metabolism of butyl p-nitrophenyl ether in vitro with rabbit liver preparations.
1. The metabolism of butyl p-nitrophenyl ether in vitro has been investigated with rabbit liver preparations. 2. Evidence for three metabolic pathways is presented. These involve initial microsomal hydroxylation at alpha, omega--1 or the omega positions of the butyl chain. 3. (omega--1)-Hydroxybutyl p-nitrophenyl ether was oxidized chiefly by the soluble fraction to the corresponding (omega--1)-oxo derivative which spontaneously decomposed to give p-nitrophenol. 4. omega-Hydroxybutyl p-nitrophenyl ether identified as a metabolite was further oxidized by the soluble fraction to p-nitrophenoxybutyric acid.
D000818:Animals; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D003640:Dealkylation; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D010647:Phenyl Ethers / Q000378:metabolism*; D011817:Rabbits; D013997:Time Factors
D010647:Phenyl Ethers