Effects of 4-aminopyridine in Eaton Lambert Syndrome.
The effects of 4-aminopyridine (a non-anticholinesterase antagonist of curare-like agents) on the evoked muscle action potentials (EMAP) in a patient with Eaton Lambert Syndrome are reported. On two separate occasions the i.v. administration of 0.31 mg kg(-1) and 0.62 mg kg(-1) was followed by a 300% increase of EMAP for about 2 h without serious side-effects.
D000200:Action Potentials / Q000187:drug effects; D005071:Evoked Potentials / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009135:Muscular Diseases / Q000503:physiopathology*; D011725:Pyridines / Q000494:pharmacology*; D013577:Syndrome; D013997:Time Factors
D011725:Pyridines