title: The effect of a single injection of papain on growth of the limb bones of the mouse.
abstract: The chondrodystrophic mouse mutant stumpy (stm) shortens proximal limb bones more than distal ones and acts late in development (circa 14 days post partum). It was thought that a late disturbance in bone growth might cause more damage to epiphyses of proximal than distal bones. This was investigated using a single injection of papain on days 8, 10 and 12: shortening of proximal and distal bones was demonstrated, but was similar in all three experimental groups.
mesh_terms: D000130:Achondroplasia / Q000139:chemically induced*; D000818:Animals; D001842:Bone and Bones / Q000187:drug effects*; D005269:Femur / Q000254:growth & development; D006811:Humerus / Q000254:growth & development; D007267:Injections; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains / Q000235:genetics; D010206:Papain / Q000008:administration & dosage / Q000494:pharmacology*; D013977:Tibia / Q000254:growth & development; D014457:Ulna / Q000254:growth & development
chemical_list: D010206:Papain