Muscimol antagonizes morphine hypermotility without potentiation of analgesia.
Muscimol, a very potent and specific GABA agonist, strongly depressed characteristic morphine-induced locomotor activity. Muscimol induced only a very weak increase in the morphine analgesia measured in the hot plate test which perhaps could be a result of a freezing reaction. No effect on morphine analgesia was observed in the wire grid test. These results indicate that GABA differentially influences morphine stimulation and analgesia.
D000698:Analgesia; D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D007555:Isoxazoles / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009020:Morphine / Q000037:antagonists & inhibitors*; D009043:Motor Activity / Q000187:drug effects*; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology*; D010080:Oxazoles / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D000700:Analgesics; D007555:Isoxazoles; D009466:Neuromuscular Blocking Agents; D010080:Oxazoles; D005680:gamma-Aminobutyric Acid; D009020:Morphine