Striatonigral degeneration.
Striatonigral degeneration is a relatively uncommon form of parkinsonism. It is clinically characterized by greater debility and a relatively rapid course, often with other superimposed extrapyramidal signs and a poor response to L-dopa. Pathologically it si a multi-system degeneration of the central nervous system, dominated by atrophy of the neostriatum with striking putaminal pigmentation. The clinical and pathological features of this condition are illustrated with a case report and the entity as a nosologic problem is discussed in the light of a review of the literature. The pathogenesis of this condition and its position among the degenerative disorders of the nervous system remain unelucidated.
D001933:Brain Stem / Q000473:pathology; D003342:Corpus Striatum / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010300:Parkinson Disease / Q000473:pathology*; D011699:Putamen / Q000473:pathology; D013378:Substantia Nigra / Q000473:pathology*