title: Incidence of meningeal involvement by rhabdomyosarcoma of the head and neck in children: a report of the Intergroup Rhabdomyosarcoma Study (IRS).
abstract: 141 patients with embryonal rhabdomyosarcoma (RMS) of the head and neck are reviewed. 57/141 had lesions of para-meningeal sites. 20/57 (35%) developed evidence of direct meningeal extension. 18/20 (90%) died of this complication. Radiation portals and doses were limited in 42% and 32%, respectively. All patients had chemotherapy for 6 weeks prior to radiation. The significance of the adequacy of radiation factors and the timing of chemotherapy are reviewed. Recommendations for managing these patients include earlier use of radiation and increased coverage of adjacent meninges by radiation including total craniospinal axis radiation when brain meningeal involvement exists.
mesh_terms: D002648:Child; D002675:Child, Preschool; D004428:Ear Neoplasms / Q000473:pathology / Q000628:therapy; D004432:Ear, Middle; D005260:Female; D006258:Head and Neck Neoplasms / Q000473:pathology* / Q000628:therapy; D006801:Humans; D008297:Male; D008578:Meninges / Q000473:pathology*; D009303:Nasopharyngeal Neoplasms / Q000473:pathology / Q000628:therapy; D010255:Paranasal Sinus Neoplasms / Q000473:pathology / Q000628:therapy; D011879:Radiotherapy Dosage; D012208:Rhabdomyosarcoma / Q000473:pathology* / Q000628:therapy