Decreased cerebral blood flow after administration of sodium bicarbonate in the distressed newborn infant.
In the course of our studies on cerebral blood flow in newborn infants, we have observed a striking depressing effect of sodium bicarbonate infusion on cerebral blood flow which in some cases may severely aggravate cerebral ischemia. We measured cerebral blood flow before and after the treatment with 1 to 8 meqs of sodium bicarbonate in seven distressed newborn infants. The 133 Xe clearance technique was used. The results showed in six of the seven cases a decrease in cerebral blood flow, which in most cases was reduced to 14 to 22 ml/100 g/min, which is about half the value prior to the bicarbonate infusion. In one case an extreme reduction occurred: cerebral blood flow was reduced to 3 ml/100 g/min, well below the level compatible with tissue survival. The results are discussed with regard to the optimal treatment of the acidotic newborn.
D001639:Bicarbonates / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D003864:Depression, Chemical; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009460:Neurologic Examination; D012127:Respiratory Distress Syndrome, Newborn / Q000188:drug therapy*
D001639:Bicarbonates