title: [The lack of damaging effect from sigetin on the development of the reproductive system in rats].
abstract: Sygethin, an estrogen-like drug, was introduced to rats of the Wistar line during critical periods marking differentiation of hypothalamic sex centers, initial development and differentiation of the mammary glands as well as the time when administration of estrogens caused irreversible changes in the testes. No deviations in the development of test animals similar to those produced by estrogens were disclosed.
mesh_terms: D000818:Animals; D001557:Benzenesulfonates / Q000494:pharmacology*; D004968:Estrogens, Non-Steroidal / Q000494:pharmacology*; D005260:Female; D005835:Genitalia / Q000187:drug effects* / Q000254:growth & development; D007031:Hypothalamus / Q000187:drug effects; D008297:Male; D008321:Mammary Glands, Animal / Q000187:drug effects / Q000254:growth & development; D051381:Rats; D012098:Reproduction / Q000187:drug effects*; D012733:Sex Differentiation / Q000187:drug effects; D013737:Testis / Q000187:drug effects / Q000254:growth & development; D013997:Time Factors
chemical_list: D001557:Benzenesulfonates; D004968:Estrogens, Non-Steroidal; C001770:sigetin
vernacular_title: Otsutstvie povrezhdaiushchege vilianiia sigetina na razvitie reproduktivnoĭ sistemy krys.