3-(p-tolyl)-4-aminobutanoic acid synthesis, resolution into enantiomers and pharmacological activity.
Racemic 3-(p-totyl)-4-aminobutyric acid was obtained, resolved into enantiomers and their absolute configuration was determined. Both the racemic acid and two enantiomers were screened for CNS activity. R (+) enantiomers is 14--27-fold more effective than the S(-) one and 1.2--2.1 fold more effective than the racemate.
D000613:Aminobutyrates / Q000494:pharmacology*; D000818:Animals; D001463:Barbiturates / Q000494:pharmacology; D001921:Brain / Q000187:drug effects*; D004357:Drug Synergism; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009129:Muscle Tonus / Q000187:drug effects; D009904:Optical Rotation; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology*
D000613:Aminobutyrates; D001463:Barbiturates; D005680:gamma-Aminobutyric Acid