[The metabolic regulation of the retinal blood flow and the role of prostaglandins (author's transl)].
The microioptophoretic injection of PGE1 close to the retinal arterioles procedures a segmental vasodilatation of 40%. The inhibition of prostaglandin synthesis with indomethacin or aspirin blocks the vasodilatatory effect of hypercapnia and, to a lesser extent, of hypoxia. These results suggest that prostaglandins play a role in the regulation of retinal vasomotor activity.
D000818:Animals; D001160:Arterioles / Q000503:physiopathology; D001241:Aspirin / Q000494:pharmacology; D006632:Histamine / Q000494:pharmacology; D006935:Hypercapnia / Q000503:physiopathology; D000860:Hypoxia / Q000503:physiopathology; D007213:Indomethacin / Q000494:pharmacology; D011458:Prostaglandins E / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000187:drug effects; D012160:Retina / Q000098:blood supply*; D012171:Retinal Vessels / Q000187:drug effects / Q000503:physiopathology; D014664:Vasodilation / Q000187:drug effects*
D011458:Prostaglandins E; D006632:Histamine; D001241:Aspirin; D007213:Indomethacin
Régulation métabolique de débit sanguin rétinien: le rôle des prostaglandines.