title: Long-term hypotensive effect of atenolol 4% eyedrops.
abstract: The effect of long-term application of 4% atenolol eye drops has been studied in patients with either glaucoma or ocular hypertension. In some patients who show a good initial response the ocular hypotensive effect gradually wears off with long-term use. This pattern of response appears to be more frequent in patients with pretreatment intraocular pressure of 25 mmHg, or greater. In combination with atenolol miotics or adrenaline show an additive effect.
mesh_terms: D000328:Adult; D000368:Aged; D001262:Atenolol / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D004837:Epinephrine / Q000627:therapeutic use; D005260:Female; D005901:Glaucoma / Q000188:drug therapy; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D008916:Miotics / Q000627:therapeutic use; D009883:Ophthalmic Solutions; D011412:Propanolamines / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D008916:Miotics; D009883:Ophthalmic Solutions; D011412:Propanolamines; D001262:Atenolol; D004837:Epinephrine