Dapsone-induced distal axonal degeneration of the motor neurons.
Dapsone proved to be effective treatment in a patient who suffered from erthema elevatum diutinum. Serious neurological side effects, however, appeared. The basic mechanism appeared to be a distal axonal degeneration of the motor neurons. Sensory conduction studies  were normal in five consecutive EMG examinations. A diagnosis of anemia pernicosa was also made bu the blood values returned to normal after starting B12-vitamin therapy. Penicous anemia seemed not be an etiological factor in the polyneuropathy of our patient because we were not able toshow any damage to the sensory axons.
D000328:Adult; D001369:Axons / Q000187:drug effects*; D003622:Dapsone / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D004890:Erythema / Q000188:drug therapy; D005260:Female; D006801:Humans; D009046:Motor Neurons / Q000187:drug effects*; D009410:Nerve Degeneration / Q000187:drug effects*; D011115:Polyneuropathies / Q000139:chemically induced*
D003622:Dapsone