Aflatoxin B1 hepatotoxicity in rats pretreated with ethanol.
Ethanol pretreatment has the potentiation of the aflatoxin B1-induced hepatotoxicity was indicated by an increase in the activities of plasma GPT, plasma GOT and in the severity of liver necrosis. The effect of ethanol pretreatment on an increase in the accumulation of liver triglycerides is additive in nature.
D000348:Aflatoxins / Q000009:adverse effects / Q000633:toxicity*; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D004357:Drug Synergism; D000431:Ethanol / Q000009:adverse effects / Q000633:toxicity*; D005260:Female; D008099:Liver / Q000378:metabolism; D051381:Rats; D014280:Triglycerides / Q000378:metabolism
D000348:Aflatoxins; D014280:Triglycerides; D000431:Ethanol; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase