title: Pyrrole, furan, and thiophene oxamates as potential antiallergy agents.
abstract: Nine heterocyclic oxamic acid derivatives were synthesized and tested in the rat passive cutaneous anaphylactic assay as potential antiallergy agents. Some compounds also were tested for their effects on cholesterol-lipoprotein levels and for diuretic, antidiabetic, and antifertility activities in rats.
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis*; D000818:Animals; D005663:Furans / Q000138:chemical synthesis / Q000494:pharmacology; D010072:Oxamic Acid / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects*; D011758:Pyrroles / Q000138:chemical synthesis / Q000494:pharmacology; D051381:Rats; D013876:Thiophenes / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D000596:Amino Acids; D005663:Furans; D011758:Pyrroles; D013876:Thiophenes; D010072:Oxamic Acid