Syntheses and pharmacological activity of N-acyl-substituted imidazolidinethiones and thioimidazolines.
A series of imidazolidinethiones and thioimidazolines was synthesized and tested for their effect on both forced and spontaneous motor activities as well as their ability to raise the convulsion threshold. The N-acyl-substituted 2-p fluorobenzylthioimidazolines were the most active compounds, producing protection against maximal electroshock seizures and tonic convulsions induced by pentylenetetrazol. Both compounds had high LD50 values and safety indexes.
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis; D004597:Electroshock; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D051381:Rats
D000927:Anticonvulsants; D007093:Imidazoles; D010433:Pentylenetetrazole