Presence of oncornavirus-like particles in the P388 murine leukemic cell line.
A culture of P388 murine lymphoblastoid cells has been shown to contain type C oncornavirus-like particles budding at the plasma membrane. Occasionally intracytoplasmic type A and immature type B particles were also observed by electron microscope techniques. The discovery of oncornavirus-like particles in the P388 cell line increases the utility of this neoplastic system for detecting potential antineoplastic agents.
D000818:Animals; D002460:Cell Line; D007942:Leukemia, Experimental / Q000382:microbiology* / Q000648:ultrastructure; D051379:Mice; D012190:Retroviridae / Q000302:isolation & purification*