Efficacy of trivalent inactivated encephalomyelitis virus vaccine in horses.
Twenty-nine horses were vaccinated with a trivalent (Venezuelan, eastern, and western) inactivated equine encephalomyelitis virus vaccine. The vaccine purchased for this study was the only one licensed and commercially available in May, 1975. Plaque-neutralizing and hemagglutinin-inhibiting antibodies in response to each of the 3 equine encephalomyelitis viruses were determined after vaccination. Horses had rising levels of plaque-neutralizing and hemagglutinin-inhibiting antibodies shortly after injection with the 1st and 2nd doses of the vaccine (given 3 weeks apart) and were refractory to challenge of immunity with virulent homologous virus at 3, 8, and 12 months after vaccination. After 12 months, 8 horses were revaccinated; maximum antigenic stimulation was achieved with the 1st dose of the 2nd series of vaccinations.
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D004663:Encephalitis Virus, Eastern Equine / Q000276:immunology; D004666:Encephalitis Virus, Venezuelan Equine / Q000276:immunology; D004667:Encephalitis Virus, Western Equine / Q000276:immunology; D004668:Encephalitis Viruses / Q000276:immunology*; D004683:Encephalomyelitis, Equine / Q000517:prevention & control / Q000662:veterinary*; D004685:Encephalomyelitis, Venezuelan Equine / Q000517:prevention & control / Q000662:veterinary; D005260:Female; D006734:Horse Diseases / Q000517:prevention & control*; D006736:Horses; D008297:Male; D014765:Viral Vaccines / Q000008:administration & dosage / Q000592:standards
D000914:Antibodies, Viral; D014765:Viral Vaccines