title: [Effect of 1-D-ribofuranosyl-1,2,4-triazol-3-carboxamide on the synthesis of cellular macromolecules in cell culture].
abstract: Ribovirine (I-D-ribofuranosyl-1,2,4-triazol-3-carboxamide) possesses the distinct antiviral action against many strains of RNA- and DNA-containing viruses. Data on the effect of ribovirine on the synthesis of cellular macromolecules are presented. After treatment with ribovirine the synthesis of cellular RNA was inhibited by 80-85%. The synthesis of DNA and proteins was decreased less distinctly. The experiments were carried out using the primary tryptic-treated culture of fibroblasts from chicken embryos.
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis*; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis*; D012254:Ribavirin / Q000494:pharmacology*; D012263:Ribonucleosides / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D012263:Ribonucleosides; D012254:Ribavirin; D012313:RNA; D004247:DNA
vernacular_title: Vliianie 1-D-ribofuranozil-1,2,4-triazol-3-karboksamida na sintez kletochnykh makromolekul v kul'ture kletok.