Lordosis induction in the rat by prostaglandin E2 systemically or intracranially in the absence of ovarian hormones.
Within 20 minutes of an intraperitoneal injection, PGE2 induced lordosis responding to manual stimulation in 6 of 9 rats that were ovariectomized-hysterectomized and hormonally untreated. Similarly, intracranial application of PGE2, through guide cannulae that were chronically-implanted in the basal hypothalamus, induced lordosis responding to manual stimulation within 10 minutes in ovariectomized, hormonally-untreated rats.
D000818:Animals; D005260:Female; D007031:Hypothalamus / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D010053:Ovary / Q000502:physiology*; D011187:Posture; D011458:Prostaglandins E / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D012726:Sexual Behavior, Animal / Q000187:drug effects*
D011458:Prostaglandins E