Effect of intravenous thiamine on pralidoxime kinetics.
Subjects were given pralidoxime chloride (5 mg/kg, intravenously) alone and again while they were receiving an infusion of thiamine hydrochloride. After the addition of thiamine: (1) overall, the urinary excretion of oxime was the same but the amount excreted in the first three hours was smaller; (2) the plasma half-life of oxime lengthened; (3) the plasma concentrations of oxime rose; and (4) the intercompartmental clearances and rate constant for elimination for oxime fell. These changes suggest that thiamine and oxime compete for a common renal secretory mechanism or that thiamine alters the membrane transport of oxime.
D000328:Adult; D004347:Drug Interactions; D006207:Half-Life; D006801:Humans; D007263:Infusions, Parenteral; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D008297:Male; D008954:Models, Biological; D011220:Pralidoxime Compounds / Q000097:blood / Q000378:metabolism*; D013831:Thiamine / Q000008:administration & dosage / Q000494:pharmacology*
D011220:Pralidoxime Compounds; D013831:Thiamine