Release of prostaglandin-like substance from inflamed synovial tissue of rat.
Influence of inflammation on the release of prostaglandin-like substance (PG) from synovial tissue of rat was studied. 1) In carrageenin inflammation, PG release was proportional to the increase in synovial tissue weight. 2) PG release was only increased in the later phase of dextran inflammation. 3) Aspirin suppressed PG release from both non-inflamed and inflamed synovial tissues, but hydrocortisone suppressed that only in inflamed tissue.
D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D002351:Carrageenan; D003911:Dextrans; D006854:Hydrocortisone / Q000494:pharmacology; D008297:Male; D011453:Prostaglandins / Q000378:metabolism*; D051381:Rats; D012636:Secretory Rate / Q000187:drug effects; D013585:Synovitis / Q000139:chemically induced / Q000378:metabolism*
D003911:Dextrans; D011453:Prostaglandins; D002351:Carrageenan; D001241:Aspirin; D006854:Hydrocortisone