title: Antagonism by morphine and pethidine of the contractile effects of PGE2 on isolated uterus of the rat.
abstract: Morphine antagonizes the twitches evoked by administration of PGE2 on spontaneous contractile activity in the isolated uterus of the rat. This action is dose-dependent. Concentrations as low as 2.6 nM completely abolished contractile activity of PGE2 added to the bath at a concentration of 0.5 ng ml-1. In contrast to morphine, pethidine partially antagonized the stimulatory action of PGE2 at much higher concentrations.
mesh_terms: D000818:Animals; D005260:Female; D066298:In Vitro Techniques; D008614:Meperidine / Q000494:pharmacology*; D009020:Morphine / Q000494:pharmacology*; D011458:Prostaglandins E / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D051381:Rats; D014590:Uterine Contraction / Q000187:drug effects*
chemical_list: D011458:Prostaglandins E; D009020:Morphine; D008614:Meperidine