Colonic anastomosis healing. The effect of topical povidone-iodine.
The effect of povidone-iodine (0.1% available iodine) irrigation on colonic anastomosis healing was investigated in 196 Sprague-Dawley rats. Each end of the divided colon was irrigated with 5 ml of povidone-iodine solution or with an equal volume of normal saline before anastomosis and again after the anastomosis had been completed. Healing was assessed at 2, 4, 6, 8, 10, and 14 days after operation: macroscopically, mechanically, histologically and angiigraphically. Povidone-iodine irrigation did not impair healing in any way.
D000287:Administration, Topical; D000792:Angiography; D000818:Animals; D003106:Colon / Q000473:pathology / Q000601:surgery*; D005260:Female; D006097:Granulation Tissue / Q000473:pathology; D011205:Povidone / Q000031:analogs & derivatives*; D011206:Povidone-Iodine / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D013529:Surgical Wound Dehiscence / Q000517:prevention & control; D013718:Tensile Strength; D007507:Therapeutic Irrigation; D014945:Wound Healing / Q000187:drug effects*
D011206:Povidone-Iodine; D011205:Povidone