[Cerebral cortical neuron tolerance to the repeated administration of diazepam].
The depressive action of intravenously injected diazepam on the spontaneous electric activity of the sensomotor cortex neurons was studied in acute tests on rabbits. After introduction of 1 mg/kg of the drug an acute tolerance of a repeat introduction of it in the same dose developing 40--60 min following the first injection was observed. Earlier after the first injection (up to 20--40 min) the tolerance was lacking. It is suggested that the tolerance of a repeat introduction of diazepam is due to a concurrent blocking of the nervous tissue receptors sensitive to diazepam by the products of its (diazepam) metabolism.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects*; D003864:Depression, Chemical; D003975:Diazepam / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004361:Drug Tolerance; D007700:Kinetics; D009474:Neurons / Q000187:drug effects*; D011817:Rabbits; D013997:Time Factors
D003975:Diazepam
Tolerantnost' neĭronov kory golovnogo mozga k povtornomu vvedeniiu diazepama.