Dominant IgM deposition in experimentally induced amyloid kidney of the mouse and its immunological implications.
Prolonged hyperimmmunization of C3H mice with casein resulted in immune deposits in glomeruli which led to subsequent amyloid deposition. During the immunization, the animals were in state of extreme antigen excess without any detectable circulating antibodies. The immunofluorescent findings in the later period revealed predominant IgM deposition in glomeruli, which was quite consistent with the dominant presence of IgM antibody-forming cells in spleen in the apparently tolerant state.
D000682:Amyloid / Q000032:analysis; D000686:Amyloidosis / Q000276:immunology* / Q000473:pathology; D000818:Animals; D000906:Antibodies / Q000032:analysis; D000941:Antigens / Q000008:administration & dosage; D002364:Caseins / Q000008:administration & dosage; D004195:Disease Models, Animal; D007075:Immunoglobulin M / Q000032:analysis*; D066298:In Vitro Techniques; D007674:Kidney Diseases / Q000276:immunology* / Q000473:pathology; D007678:Kidney Glomerulus / Q000276:immunology; D051379:Mice; D008809:Mice, Inbred C3H
D000682:Amyloid; D000906:Antibodies; D000941:Antigens; D002364:Caseins; D007075:Immunoglobulin M