Haemodialysis in rats.
A plate dialyser requiring an extracorporeal blood volume of 1.5 ml was developed to dialyse conscious rats. In experiments in vitro and in vivo its function was tested. The in vitro clearances of urea, creatinine and potassium were 126+/-9 ml/min/m2, 70.5+/-9 ml/min/m2, and 132.5+/-13 ml/min/m2, respectively. The method appears to be suitable for pharmacological and toxicological studies.
D000818:Animals; D003404:Creatinine / Q000097:blood; D005260:Female; D007688:Kidneys, Artificial; D051381:Rats / Q000502:physiology*; D014508:Urea / Q000097:blood
D014508:Urea; D003404:Creatinine