Prolonged treatment of menetrier's disease with an oral anticholinergic drug.
There is considerable evidence, both in patients with Menetrier's disease and from animal models of protein-losing gastropathy, that antisecretory drugs can acutely decrease or abolish gastric plasma protein shedding. Serial measurements on serum protein components were performed in a patient with Menetrier's disease before, during, and after long term treatment with propantheline bromide. Total serum protein concentration increased significantly during the treatment period from 4.3 +/- 0.50 to 5.9 +/- 0.55 g per dl during treatment, while albumin increased from a pretreatment value of 2.5 +/- 0.12 to 3.4 +/- 0.16 g per dl. The improvement in serum proteins and symptoms continued after therapy was stopped. Intensive anticholinergic drug therapy should be tried in this disease before resorting to gastrectomy.
D000284:Administration, Oral; D000328:Adult; D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D005753:Gastric Mucosa / Q000473:pathology; D005756:Gastritis / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D006984:Hypertrophy; D008297:Male; D011413:Propantheline / Q000008:administration & dosage* / Q000627:therapeutic use; D011504:Protein-Losing Enteropathies / Q000188:drug therapy / Q000473:pathology; D012709:Serum Albumin / Q000378:metabolism
D001798:Blood Proteins; D012709:Serum Albumin; D011413:Propantheline