[Effect of experimental arrest of eye growth on the proliferation and polyploidization of the retinal pigment epithelium in rats].
Following the lens removal from the left eye of the newborn rats, animals were obtained with one normal (control) and another microphtalmic eye. The animals were sacrificed on the 2nd, 3rd, 5th, 7th and 9th days of postnatal development after four injections of 3H-thymidine during 19 hrs. The number of labelled nuclei and mono- and binuclear cells in the central zone of the eye fundus was counted on the autographs. After the initial increase of the index of labelled nuclei in the operated eyes (on the 2nd, 3rd and 5th days) it fell below the control level (on the 7th and 9th days). The number of binuclear cells in the operated eyes, as well as in the control, attains on the 5th day 50% of the total number of cells and remains at this level up to the end of the experiment, whereas in the control eyes the number of binuclear cells increases up to 60% on the 7th and 80% on the 9th day. The results obtained have shown that in rats the factors of total eye growth participate in the control of proliferative activity and polyploidization of the pigment epithelium cells in the retina.
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001345:Autoradiography; D002455:Cell Division; D005123:Eye / Q000254:growth & development*; D007429:Intraocular Pressure; D007908:Lens, Crystalline / Q000502:physiology; D008850:Microphthalmos / Q000503:physiopathology; D010857:Pigment Epithelium of Eye / Q000166:cytology*; D011123:Polyploidy; D051381:Rats; D011919:Rats, Inbred Strains
Vliianie éksperimental'noĭ zaderzhki rosta glaza na proliferatsiiu i poliploidizatsiiu kletok pigmentnogo épiteliia setchatki u krys.