The clinical genetics of Pick's disease.
The families of 11 probands with Pick's disease as determined by histopathological examination, were investigated by interview and acquisition of medical records. The estimated morbid risk was 0.25 +/- 0.08 for parents and 0.07 +/- 0.07 for siblings or probands. Further analyses are presented that seek associations between morbid risk and age, sex and age of onset. Data needed for genetic counseling are included.
D000328:Adult; D000368:Aged; D003704:Dementia / Q000235:genetics*; D005260:Female; D005817:Genetic Counseling; D006801:Humans; D008297:Male; D008875:Middle Aged