Investigations on the modification of postirradiation pancreatic lipase activity by some endo- or exogenic factors. Part II. The influence of some ions, biogenic amines and hormones.
The subject of investigations was the influence of some endogenic substances: ions (K+ and Ca++), amines (serotonin, histamine and acetylcholine) and hormones (hydrocortisone and glucagon) on the lipase release from pancreatic granules (zymogen and lysosomes) of control and irradiated rats (800 R=24 hours). The decrease of enzyme release under the influence of hydrocortisone (both concentrations: 10(-6) and 10(-8) M), Ca++ ions, serotonin, histamine and acetylcholine after their administration in greater concentration (10(-6) M) was stated. Smaller concentrations of these substances evoked the transitory enhancement of enzyme activity. K+ ions and glucagon increased the lipase release (both concentrations). In the fraction of organelles from irradiated rats the action of K+ ions, glucagon and acetylcholine was diminished or abolished, while the inhibitory effectiveness (of greater concentrations) of Ca++ ions, serotonin, histamine and hydrocortisone was maintained.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001679:Biogenic Amines / Q000494:pharmacology*; D002118:Calcium / Q000494:pharmacology; D005260:Female; D005934:Glucagon / Q000494:pharmacology; D006632:Histamine / Q000494:pharmacology; D006728:Hormones / Q000494:pharmacology*; D006854:Hydrocortisone / Q000494:pharmacology; D007477:Ions / Q000494:pharmacology*; D008049:Lipase / Q000378:metabolism*; D008297:Male; D010179:Pancreas / Q000187:drug effects / Q000201:enzymology* / Q000528:radiation effects; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000494:pharmacology
D001679:Biogenic Amines; D006728:Hormones; D007477:Ions; D012701:Serotonin; D006632:Histamine; D005934:Glucagon; D008049:Lipase; D000109:Acetylcholine; D011188:Potassium; D002118:Calcium; D006854:Hydrocortisone