[Protective action of vitamins and amino acids against the cytotoxic effect of phosphamide and Acrex].
Tests on a culture of embryonal fibroblast cells furnished preliminary data on a possible use of vitamins C, PP, folic acid and methionine in preventing the toxic effects of phosphamide and acrex. An appreciable lowering of the degeneration factor in cultivated cells produced by the cytotoxic action of phosphamide was noted in the presence of vitamin C, methionine, folic acid, choline hydrochloride and vitamin PP and of that exerted by acrex-by adding into the incubation medium of vitamins B1, B2, C, PP, folic acid or methionine. It is advisable that these substances be subjected to a continued investigation in animals with a view of elaborating practical recommendations for their utilization in preventing toxic effects of pesticides on the human organism.
D000818:Animals; D000931:Antidotes; D002478:Cells, Cultured; D002794:Choline / Q000627:therapeutic use*; D004117:Dimethoate / Q000633:toxicity*; D004136:Dinitrobenzenes / Q000633:toxicity*; D004353:Drug Evaluation, Preclinical; D066298:In Vitro Techniques; D008715:Methionine / Q000627:therapeutic use*; D009578:Nitrobenzenes / Q000633:toxicity*; D013997:Time Factors; D014815:Vitamins
D000931:Antidotes; D004136:Dinitrobenzenes; D009578:Nitrobenzenes; D014815:Vitamins; C004789:dinobuton; D008715:Methionine; D002794:Choline; D004117:Dimethoate
Zashchitnoe deĭstvie nekotorykh vitaminov i aminokislot ot tsitotoksicheskogo éffekta fosfamida i akreksa.