Bronchodilator effect of delta1-tetrahydrocannabinol.
1 delta1-trans-tetrahydrocannabinol, (delta1-THC) produces bronchodilatation in asthmatic patients. 2 Administered in 62 microliter metered volumes containing 50--200 microgram by inhalation from an aerosol device to patients judged to be in a steady state, it increased peak expiratory flow rate (PEFR) and forced expiratory volume in 1 second (FEV1). 3 The rate of onset, magnitude, and duration of the bronchodilator effect was dose related.
D000328:Adult; D000368:Aged; D001249:Asthma / Q000503:physiopathology; D001993:Bronchodilator Agents; D013759:Dronabinol / Q000494:pharmacology*; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008875:Middle Aged; D010366:Peak Expiratory Flow Rate; D013997:Time Factors
D001993:Bronchodilator Agents; D013759:Dronabinol