Renal lesions induced induced by tilorone and an analog. Ultrastructure and acid phosphatase study.
Tilorone, 2,7-bis-(diethylaminoethoxy)-fluoren-9-one hydrochloride, an interferon inducer, has been shown to cause hydropic degeneration in choroid plexus and distal convoluted tubules of kidney. Ultrastructural and histochemical studies of the renal lesion produced by tilorone and one of its analogs revealed striking accumulation of vacuoles and/or acid-phosphatase-positive lemellar bodies retricted to glomeruli, ascending limb of Henle's loop, and distal convoluted tubules.
D000469:Alkaline Phosphatase / Q000032:analysis; D000818:Animals; D005449:Fluorenes / Q000494:pharmacology*; D007678:Kidney Glomerulus / Q000187:drug effects* / Q000648:ultrastructure; D007684:Kidney Tubules / Q000187:drug effects*; D007686:Kidney Tubules, Distal / Q000648:ultrastructure; D008138:Loop of Henle / Q000648:ultrastructure; D008297:Male; D009940:Organoids / Q000648:ultrastructure*; D051381:Rats; D013994:Tilorone / Q000031:analogs & derivatives / Q000494:pharmacology*; D014617:Vacuoles / Q000201:enzymology / Q000648:ultrastructure*
D005449:Fluorenes; D000469:Alkaline Phosphatase; D013994:Tilorone