[Guinea pig brain and spinal cord glycolipids in tricresyl phosphate poisoning].
Experimental neuroparalytic form of chronic intoxication with tricresylphosphate (TCP was induced in adult guinea pigs by means of single intracutaneous administration of TCP (industrial mixture containing 37% of ortho-isomer) at a dose of 2.0-2.2 ml/kg of body weight. Moderate and severe forms of the impairment, accompanied by paresis and paralysis of hind extremities was developed in 66.1% of the treated animals. Content of galactolipids (cerebrosides + sulphatides) and gangliosides was determined in brain stem, lumbar and sacral parts of spinal cord of intact and impaired animals. Content of galactolipids was distinctly decreased in spinal cord (by 22.9%) and in brain stem (9.0%). Total gangliosides were decreased by 19.1% in spinal cord, but its content was altered in brain stem. These alterations appear to reflect destructive processes not only in myelin membranes but also in structure of neurones.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002554:Cerebrosides / Q000378:metabolism; D002908:Chronic Disease; D003408:Cresols / Q000506:poisoning*; D005732:Gangliosides / Q000378:metabolism; D006017:Glycolipids / Q000378:metabolism*; D006168:Guinea Pigs; D008297:Male; D013116:Spinal Cord / Q000378:metabolism*; D013433:Sulfoglycosphingolipids / Q000378:metabolism; D014317:Tritolyl Phosphates / Q000506:poisoning*
D002554:Cerebrosides; D003408:Cresols; D005732:Gangliosides; D006017:Glycolipids; D013433:Sulfoglycosphingolipids; D014317:Tritolyl Phosphates
Glikolipidy golovnogo i spinnogo mozga morskikh svinok pri intoksikatsii trikrezilfosfatom.