Induction of the six c/sec spike and wave by diphenhydramine hydrochloride in healthy male adults.
Diphenhydramine hydrochloride (DPHm) solution 1.5% was given intravenously to 375 healthy males (mean age; 23.8 years) at a rate of 30 mg/min. The dosages injected were 2 mg/kg (N=157); 1.5 mg/kg (N=94); 10 mg/kg (N=72); 0.5 mg/kg (N=52). As a result, the 6 c/sec spike and wave discharges (WSP) was found in 19.7%, 9.6%, 20.8%, and 15.4% of cases, respectively. Comparisons were made between the WSP incidence versus past histories and Cornell Medical Index results, and between WSP positive and WSP negative subjects. No significant differences were observed in any of these parameters.
D000293:Adolescent; D000328:Adult; D003321:Cornell Medical Index; D004155:Diphenhydramine / Q000494:pharmacology*; D004569:Electroencephalography; D006801:Humans; D008297:Male
D004155:Diphenhydramine