[Effect of naproxen on the thrombocyte bleeding time and on the anticoagulant treatment with phenprocoumon].
With a dose of 250 mg b.i.d. naproxen causes a slight, apparently clinically not relevant alteration of the primary bleeding pattern. Against phenprocoumon, naproxen has a transient hypoprothrombinemic effect which is followed by a short phase of increased tolerance. A further influence on anticoagulant therapy is not shown.
D015110:4-Hydroxycoumarins / Q000627:therapeutic use*; D001777:Blood Coagulation / Q000187:drug effects*; D001792:Blood Platelets / Q000187:drug effects; D004357:Drug Synergism; D006801:Humans; D009288:Naproxen / Q000494:pharmacology*; D010644:Phenprocoumon / Q000627:therapeutic use*
D015110:4-Hydroxycoumarins; D009288:Naproxen; D010644:Phenprocoumon
Zum Einfluss von Naproxen auf die thrombozytäre Blutstillung und die Antikoagulantien-Behandlung mit Phenprocoumon.