title: Thymidine kinase heterozygous L5178Y mouse lymphoma forward mutational assay.
abstract: The biological basis and protocol for the thymidine kinase heterozygous L5178Y mouse lymphoma forward mutational assay (TK+/-) are described. The TK+/- assay is used for the detection of mutations produced by chemicals or radiation.
mesh_terms: D000818:Animals; D001681:Biological Assay; D002460:Cell Line; D006579:Heterozygote; D008223:Lymphoma / Q000032:analysis*; D051379:Mice; D009153:Mutagens / Q000032:analysis*; D009374:Neoplasms, Experimental / Q000032:analysis; D013937:Thymidine Kinase / Q000032:analysis*
chemical_list: D009153:Mutagens; D013937:Thymidine Kinase