title: Marked reduction of spectrinin hereditary spherocytosis in the common house mouse.
abstract: In contrast to the disease in humans, hereditary spherocytosis in the common house mouse produces an extreme spherocytosis. The cells show a broad distribution in size ranging from microcytic to macrocytic. Of particular interest is the finding of a substantial reduction in the major membrane polypeptide called spectrin, supporting a critical role for this protein in the control of erythrocyte shape and membrane stability.
mesh_terms: D000818:Animals; D004591:Electrophoresis, Polyacrylamide Gel; D004910:Erythrocyte Membrane; D008565:Membrane Proteins / Q000172:deficiency*; D051379:Mice; D010455:Peptides; D013049:Spectrin / Q000172:deficiency*; D013102:Spherocytes; D013103:Spherocytosis, Hereditary / Q000097:blood* / Q000235:genetics
chemical_list: D008565:Membrane Proteins; D010455:Peptides; D013049:Spectrin