The effect of aliphatic alcohols on certain vitamins of the B-complex group in the liver of the rat.
The effect of the oral administration of a series of aliphatic alcohols (methanol to butanol) in addition to isopropanol on the liver contents of thiamine, riboflavin, pyridoxine, niacin, and pantothenic acid was investigated in rats. It was found the tested alcohols caused a significant decrease in the liver contents of the studied vitamins. This effect was observed after daily oral administration of the tested alcohols in doses of 1 and 2 mg/kg for 7 days. The diminishing effect of alcohols on the liver contents of vitamins was directly proportional to the dose administered.
D000438:Alcohols / Q000494:pharmacology*; D000818:Animals; D008099:Liver / Q000032:analysis / Q000187:drug effects*; D008297:Male; D051381:Rats; D014803:Vitamin B Complex / Q000032:analysis*
D000438:Alcohols; D014803:Vitamin B Complex