Discriminant analysis and structure-activity relationships. 1. Naphthoquinones.
Discriminant analysis has been used to study the data for naphthoquinones as antitumor agents in three different animal tumor systems. In each case the most significant variables for classifying the compounds into two groups according to their antitumor activities were determined by a stepwise procedure. The usefulness of discriminant analysis in the design of drugs is discussed.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D007939:Leukemia L1210 / Q000188:drug therapy; D051379:Mice; D009285:Naphthoquinones / Q000494:pharmacology* / Q000627:therapeutic use; D012513:Sarcoma, Experimental / Q000188:drug therapy; D013223:Statistics as Topic; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D009285:Naphthoquinones