[Changes in peroxidation under conditions of 3,4-benzypyrene-induced carcinogenesis].
The activities of enzymatic systems generating and destroying peroxides and the lipid peroxide content in neoplastic rat liver and 3,4-benzpyrene-induced sarcoma were studied. The tumour was characterized by high activity of glutathione peroxidase and low activity of catalase. No urate- and glycolate oxidases or ascorbat dependent peroxidation of lipids and lipid peroxides were found in the tumour. In the liver of neoplastic animals the activities of glutathione peroxidase and NADPH-dependent system of microsomal phospholipid peroxidation and the lipd peroxides content were increased, whereas the activities of catalase and urate oxidase were decreased.
D000429:Alcohol Oxidoreductases / Q000378:metabolism; D000818:Animals; D001580:Benzopyrenes; D002374:Catalase / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D006016:Glycolates; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism*; D008113:Liver Neoplasms / Q000139:chemically induced / Q000378:metabolism*; D008862:Microsomes, Liver / Q000378:metabolism; D010545:Peroxides / Q000378:metabolism*; D051381:Rats; D012513:Sarcoma, Experimental / Q000139:chemically induced / Q000378:metabolism; D014503:Urate Oxidase / Q000378:metabolism
D001580:Benzopyrenes; D006016:Glycolates; D010545:Peroxides; D000429:Alcohol Oxidoreductases; C020821:glycollate oxidase; D002374:Catalase; D005979:Glutathione Peroxidase; D014503:Urate Oxidase
Izmeneniia Perekisnogo obmena pri kantserogeneze, indutsiruemom 3,4-benzpirenom.