Multivesicular bodies in cortical dendrites of two patients with Alzheimer's disease.
Biopsy fragments from the frontal cortex of 2 patients with Alzheimer's disease were studied with ultrastructural and cytochemical methods. A great number of light and dark, acid phosphatase positive, multivesicular bodies were observed in dendrites and their spines, in all cortical layers, being more abundant in layers 3 and 4. A close topographic relationship between these organelles and post-synaptic membranes was found. It is postulated that these findings might be related to the neurite formation of the senile plaques and to the synaptic involvement in Alzheimer's disease.
D000544:Alzheimer Disease / Q000473:pathology*; D003704:Dementia / Q000473:pathology*; D003712:Dendrites / Q000648:ultrastructure; D005260:Female; D005625:Frontal Lobe / Q000648:ultrastructure*; D006801:Humans; D008854:Microscopy, Electron; D008875:Middle Aged