Postsynaptic effects of 4-aminopyridine in the sixth abdominal ganglion of the cockroach.
The synaptic action of 4-aminopyridine (4-AP) was studied in the sixth abdominal ganglion of the cockroach Periplaneta americana L. The drug 4-AP did not modify the affinity of cholinergic receptors. At concentrations above 10(-4)M, 4-AP depolarized the postsynaptic membranes even after blockage of muscarinic and nicotinic receptors by antagonistic substances.
D000818:Animals; D003058:Cockroaches; D004594:Electrophysiology; D005724:Ganglia / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D011725:Pyridines / Q000494:pharmacology*; D011950:Receptors, Cholinergic / Q000187:drug effects; D013569:Synapses / Q000187:drug effects*
D011725:Pyridines; D011950:Receptors, Cholinergic