title: [Morphology and DNA content of cultures from normal and dysplastic epithelium, carcinoma in situ and carcinomas of the cervix uteri (author's transl)].
abstract: Morphology and DNA content were studied in explantate cultures of normal epithelium, persisting intraepithelial atypias (dysplasias and carcinomas in situ) and carcinomas of the cervix uteri. Intraepithelial atypias and carcinomas can be distinguished from the normal epithelium, growing strictly as a monolayer, chiefly by the primary and secondary loosening of the cellular lawn with increased tendency towards overlapping of cells. DNA determinations provide the possibility of demonstrating, also in vitro, deviations of the DNA content of dysplasias, carcinomas in situ and pavement epithelial carcinomas from the normal epithelium. The findings are in accord with the results which we obtained by in vivo studies and underlinions.
mesh_terms: D001706:Biopsy; D002278:Carcinoma in Situ / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D046508:Culture Techniques; D004247:DNA / Q000032:analysis*; D005260:Female; D006801:Humans; D002578:Uterine Cervical Dysplasia / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000473:pathology*
chemical_list: D004247:DNA
vernacular_title: Morphologie und DNS-Gehalt von Kulturen aus normalem und dysplastischem Plattenepithel, Carcinomata in situ und Plattenepithelkarzinomen der Cervix uteri.