title: Histologic effects of Amipaque (metrizamide) and various contrast media on mouse peritoneum.
abstract: The histologic effects of Amipaque and various commonly used contrast media on mouse peritoneum were studied by intraperitoneal injections of Amipaque 370 mg I/ml and 170 mg I/ml, Conray 300 mg I/ml, Conray Meglumine 282 mg I/ml, Urografin 60% and 76%, Gastrografin and barium sulfate. Amipaque and the other water-soluble media cause no deleterious effects, whereas barium sulfate evokes granulomatous inflammatory reaction. Amipaque is suitable for gastrointestinal studies when leakage into the peritoneal cavity is expected.
mesh_terms: D000818:Animals; D001466:Barium Sulfate / Q000633:toxicity; D003287:Contrast Media / Q000633:toxicity*; D003973:Diatrizoate / Q000633:toxicity; D005260:Female; D007482:Iothalamate Meglumine / Q000633:toxicity; D007483:Iothalamic Acid / Q000633:toxicity; D008297:Male; D008793:Metrizamide / Q000633:toxicity*; D051379:Mice; D010537:Peritoneum / Q000187:drug effects*
chemical_list: D003287:Contrast Media; D003973:Diatrizoate; D007483:Iothalamic Acid; D001466:Barium Sulfate; D008793:Metrizamide; D007482:Iothalamate Meglumine