[The influence of cyclophosphane and phenthyrine and their combination with zymosan and serotonin on the functional features distingusihing peritoneal macrophages in mice].
Radiometric analysis into phagocytic activity of macrophages in intact and tumourous mice following introduction to them of phenthyrine and cyclophosphane showed the former to suppress to a greater extent the absorption function and the latter--that of digestion. A combined application of phenthyrine and cyclophosphane together with serotonin helps re-establish the microphages function in tumourous animals and to heighten the antineplastic activity of these compounds. Zymosan and its combination with phenthyrine and cyclophosphane do not produce any positive effect on the peritoneal cells.
D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology / Q000187:drug effects; D003520:Cyclophosphamide / Q000494:pharmacology*; D004357:Drug Synergism; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects* / Q000502:physiology / Q000503:physiopathology; D051379:Mice; D009374:Neoplasms, Experimental / Q000503:physiopathology; D009588:Nitrogen Mustard Compounds / Q000494:pharmacology*; D010587:Phagocytosis / Q000187:drug effects; D012701:Serotonin / Q000494:pharmacology*; D014443:Tyrosine / Q000031:analogs & derivatives / Q000494:pharmacology; D015054:Zymosan / Q000494:pharmacology*
D007166:Immunosuppressive Agents; D009588:Nitrogen Mustard Compounds; D012701:Serotonin; D014443:Tyrosine; D003520:Cyclophosphamide; D015054:Zymosan
Bliinie tsiklofosfana, fentirina i ikh kombinatsiĭ a zimozanom i serotoninom na funktsional'nye osobennosti peritoneal'nykh makrofagov mysheĭ.