Reduced analgesic effects of morphine after bilateral lesions of the locus coeruleus in rats.
Noradnenaline-depleting lesions involving the locus coerulcus markedly reduced morphine analgesia. Rats were tested for analgesia using the tail-compression method. The results indicate that locus coeruleus plays an important role in analgesic action of morphine.
D000698:Analgesia; D000818:Animals; D001923:Brain Chemistry; D004298:Dopamine / Q000032:analysis; D004556:Electric Injuries; D006897:Hydroxyindoleacetic Acid / Q000032:analysis; D008125:Locus Coeruleus / Q000293:injuries / Q000502:physiology*; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009638:Norepinephrine / Q000032:analysis; D051381:Rats; D012701:Serotonin / Q000032:analysis
D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D009020:Morphine; D004298:Dopamine; D009638:Norepinephrine