Anthelminthic effect of oxantel and oxantel-pyrantel in intestinal nematode infections.
704 patients with intestinal nematode infestation were treated with oxantel and oxantel-pyrantel in either liquid or tablet form, at doses from 10 to 25mg/kg. All were given the drug or drugs as a single dose. In 699 patients with trichuriasis cure rates between 64 and 93% were obtained and there were egg reduction rates of between 90 and 100%. The best results were obtained using oxantel, either alone or in combination with pyrantel, at 15 to 20mg/kg. Only 2 of 152 patients with ascariasis were not cured after a single dose of pyrantel (given as oxantel-pyrantel) of 10, 15 or 20mg/kg, and both these patients were from the group given the lowest dose. Only mild side-effects were noted. The combination, oxantel-pyrantel is a safe and effective treatment for multiple intestinal nematode infection.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D004338:Drug Combinations; D005243:Feces / Q000469:parasitology; D005260:Female; D006801:Humans; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy* / Q000469:parasitology; D008297:Male; D008875:Middle Aged; D009349:Nematode Infections / Q000188:drug therapy* / Q000469:parasitology; D010270:Parasite Egg Count; D011715:Pyrantel / Q000627:therapeutic use*; D011743:Pyrimidines / Q000627:therapeutic use*; D013343:Styrenes / Q000627:therapeutic use
D004338:Drug Combinations; D011743:Pyrimidines; D013343:Styrenes; D011715:Pyrantel