title: Relative carcinogenic effectiveness of derivatives of nitrosodiethylamine in rats.
abstract: The carcinogenicity of five derivatives of nitrosodiethylamine was compared with that of the parent compound by p.o. administration to rats. All were less potent than was nitrosodiethylamine. When nitrosobis(2-methoxyethyl)amine and nitrosobis(2-ethoxyethyl)amine were administered at equimolar doses in drinking water, there was a high incidence of liver tumors, but the animals died later than they did after nitrosodiethylamine treatment, which also induced esophageal tumors. Nitrosoiminodipropionitrile and nitrosobis(2,2-diethoxyethyl)amine failed to induce tumors at the same dose level. Nitrosobis(2-chloroethyl)amine was administered in oil by gavage at a dose lower than that of nitrosodiethylamine and produced a much weaker tumor response; 5 of 15 treated rats had forestomach papillomas, and 1 had olfactory adenocarcinoma and no other induced tumors.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004052:Diethylnitrosamine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000633:toxicity*; D004938:Esophageal Neoplasms / Q000139:chemically induced; D008113:Liver Neoplasms / Q000139:chemically induced; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D009602:Nitrosamines / Q000633:toxicity*; D009669:Nose Neoplasms / Q000139:chemically induced; D051381:Rats; D013274:Stomach Neoplasms / Q000139:chemically induced; D013329:Structure-Activity Relationship
chemical_list: D009602:Nitrosamines; D004052:Diethylnitrosamine