Effect of variations in temperature on antimuscarinic activity in guinea-pig atria.
The characteristics of the antimuscarinic activity of homatropine, gallamine and stercuronium in guinea-pig atria remained constant over the temperature range 22--37 degrees C in that a linear Arunlakshana-Schild plot was obtained with homatropine and nonlinear plots occurred with gallamine or stercuronium. A trend towards higher dose-ratios with reduction in temperature was only significant for gallamine.
D000470:Alkaloids / Q000494:pharmacology; D000818:Animals; D001286:Atropine Derivatives / Q000494:pharmacology; D005703:Gallamine Triethiodide / Q000494:pharmacology; D006168:Guinea Pigs; D006325:Heart Atria / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects*; D010276:Parasympatholytics / Q000494:pharmacology*; D011245:Pregnadienes / Q000494:pharmacology; D011759:Pyrrolidines / Q000494:pharmacology; D013696:Temperature
D000470:Alkaloids; D001286:Atropine Derivatives; D010276:Parasympatholytics; D011245:Pregnadienes; D011759:Pyrrolidines; D005703:Gallamine Triethiodide; C003344:stercuronium