Electron microscopic study of the effects of thallium poisoning on the rat cerebellum.
Rats were given thallium acetate (5 mg elemental thallium/kg body weight) intra-peritoneally daily for 7 days. The brain was fixed by perfusion-fixation and small pieces of the cerebellum were processed for electron microscopy. Variegated mitochondrial profiles, increased incidence of electron--dense bodies and proliferation of Golgi zones were observed in the thallium--poisoned rat cerebellum. Multilamellar cytoplasmic bodies were discernible in the cerebellar cortex of the thallium-treated rats.
D000818:Animals; D002531:Cerebellum / Q000187:drug effects* / Q000648:ultrastructure; D007274:Injections, Intraperitoneal; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D013793:Thallium / Q000008:administration & dosage / Q000633:toxicity*
D013793:Thallium