title: [A new surgical lavage].
abstract: The application in purulent peritonitis of a novel surgical lavaging agent with unique properties is reported. Taurolin is a non-toxic formaldehyde-transmitter with a Thiadiazine structure exhibiting a twofold action in gram-negative sepsis owing to its bactericidal potency and its ability to denature endotoxins in vivo. The present study reports the surgical treatment of 62 patients with appendicitis and peritonitis of varying genesis, using 0.5% Taurolin as lavaging and 2% Taurolin as instillation agents. After 5 days 22 out of 25 patients with purulent peritonitis were void of intraperitoneal bacteria. To date no significant adverse drug reactions were observed.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001064:Appendicitis / Q000601:surgery*; D001424:Bacterial Infections / Q000188:drug therapy*; D055598:Chemical Phenomena; D002621:Chemistry; D002648:Child; D002675:Child, Preschool; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010538:Peritonitis / Q000601:surgery*; D007507:Therapeutic Irrigation; D013829:Thiadiazines / Q000627:therapeutic use*; D013843:Thiazines / Q000627:therapeutic use*
chemical_list: D013829:Thiadiazines; D013843:Thiazines
vernacular_title: Neuartige chirurgische Spüllösung.