title: [Effect of industrial contact with grizin on nonspecific immunity factors].
abstract: Data on the dynamic examination of persons being in professional contact with grizin, an antibiotic used as a food additive are presented. It was shown that contact with grizin resulted in changes in the humoral, cell and barrier factors of the non-specific immunity. The trends of the changes and their manifestations were different depending on the age, period and contact level. The levels of lysozyme, absorption and digestion activity of the neutrophils provided differentiation of the adaptive reactions and phenomena of frustation in the compensatory mechanism. The methods used in the study allowed the authors to detect changes in the state of the nonspecific immunological reactivity of the persons being in contact with grizin before the appearance of the clinicaly pronounced forms of the pathology.
mesh_terms: D000328:Adult; D000367:Age Factors; D000900:Anti-Bacterial Agents / Q000276:immunology*; D004345:Drug Industry; D004781:Environmental Exposure; D004789:Enzyme Activation / Q000187:drug effects; D005260:Female; D006801:Humans; D007109:Immunity / Q000187:drug effects; D007111:Immunity, Cellular / Q000187:drug effects; D007113:Immunity, Innate / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009113:Muramidase / Q000037:antagonists & inhibitors; D010587:Phagocytosis / Q000187:drug effects; D014586:USSR
chemical_list: D000900:Anti-Bacterial Agents; D009113:Muramidase
vernacular_title: Vliianie proizvodstvennogo kontakta s grizinom na nekotorye nespetsificheskogo immuniteta.