title: [The activity of microsomal hepatic cytochromes as affected by x-ray contrast media].
abstract: Tests on rats evidenced that X-ray contrast media can bring down the cytochrome P-450 content in the endoplasmatic reticulum of hepatic cells. The observed effect is most characteristic of cholecystrographic substances and is not linked with intesified processes of lipids peroxidation in themicrosomal membranes.
mesh_terms: D000818:Animals; D002765:Cholecystography; D003287:Contrast Media / Q000494:pharmacology*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004721:Endoplasmic Reticulum / Q000187:drug effects / Q000201:enzymology; D066298:In Vitro Techniques; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D051381:Rats
chemical_list: D003287:Contrast Media; D003577:Cytochrome P-450 Enzyme System
vernacular_title: Aktivnost' mikrosomal'nykh tsit-khromov pecheni pri deistvii rentgenokontrastinykh veshchestv.