title: Relationship between steroid permeability across excised rabbit cornea and octanol-water partition coefficients.
abstract: Permeability rates were determined across excised rabbit corneas for 11 steroids. Permeability coefficients for each steroid were calculated, and their logarithms were plotted against their respective log octanol-water partition coefficients. A parabolic relationship resulted, with an optimum log permeability and coefficient observed at a log Po of 2.9. From these experimental results, an improvement in ophthalmic bioavailability of dexamethasone acetate as compared to dexamethasone is predicted and correlates with literature results.
mesh_terms: D000818:Animals; D003315:Cornea / Q000378:metabolism*; D003907:Dexamethasone / Q000378:metabolism; D066298:In Vitro Techniques; D008954:Models, Biological; D010539:Permeability; D011817:Rabbits; D012995:Solubility; D013256:Steroids / Q000378:metabolism*
chemical_list: D013256:Steroids; D003907:Dexamethasone