[Vasoactive drugs and oxygen content in the perilymph (author's transl)].
The effect of different vasodilating drugs on the perilymphatic oxygen content in the cat has been examined by means of the polarographic method. The drugs used such as Papaverin, Rheomacrodex, Ronicol, Praxilen and Lasix have had no significant effect on the oxygen concentration in the perilymph. Histamin, 7% Na2CO3 and 50% glycerol have produced a diminution of the perilymphatic oxygen tension. Only angiotensin has produced a 20% rise of the oxygen pressure in the perilymph. This effect is, however, five times smaller than that reached by inhalation of 5% CO2 and 95% O2.
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D002415:Cats; D003911:Dextrans / Q000494:pharmacology; D005665:Furosemide / Q000494:pharmacology; D005990:Glycerol / Q000494:pharmacology; D006632:Histamine / Q000494:pharmacology; D007761:Labyrinthine Fluids / Q000378:metabolism*; D009540:Nicotinyl Alcohol / Q000494:pharmacology; D010101:Oxygen Consumption / Q000187:drug effects*; D010208:Papaverine / Q000494:pharmacology; D010498:Perilymph / Q000378:metabolism*; D014662:Vasoconstrictor Agents / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000494:pharmacology*
D003911:Dextrans; D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents; D000804:Angiotensin II; D005665:Furosemide; D006632:Histamine; D009540:Nicotinyl Alcohol; D010208:Papaverine; D005990:Glycerol
Vasoaktive Substanzen und Sauerstoffgehalt der Perilymphe.