Studies on polypeptides. XXVI. Synthesis of the N-terminal 1--23 peptide sequence of rat pancreatic ribonuclease; enzymatic activity of the hybrid complex with bovine S-protein.
A description is given of the synthesis by fragment condensation of the peptide Gly-Glu-Ser-Arg-Glu-Ser-Ser-Ala-Asp-Lys-Phe-Lys-Arg-Gln-His-Met-Asp-Thr-Glu-Gly-Pro-Ser-Lys corresponding to the 1--23 amino acid sequence of rat pancreatic ribonuclease. This rat peptide combined with bovine S-protein yields a fully active ribonuclease S' analogue.
D000595:Amino Acid Sequence; D000818:Animals; D002417:Cattle; D006822:Hybrid Cells / Q000201:enzymology*; D010179:Pancreas / Q000201:enzymology*; D010446:Peptide Fragments; D011506:Proteins; D051381:Rats; D012260:Ribonucleases / Q000032:analysis / Q000138:chemical synthesis*; D013455:Sulfur
D010446:Peptide Fragments; D011506:Proteins; D013455:Sulfur; D012260:Ribonucleases