title: A study on the IgE levels of military recruits and association with HLA antigens.
abstract: To identify antigen marker(s) on lymphocytes for the immunoregulation of IgE immunoglobulin. For this purpose, IgE determinations were performed on 58 recruits who were arbitrarily selected for HLA typing. Thirty-three recruits with IgE values ranging from 24 to 142 U/ml (71 U/ml (71 U/ml average) showed a slight increase in incidence for HLA-A23, -A33 and BW-15 when compared to a group of 25 recruits whose IgE values ranged from 153 to 2128 U/ml (615 U/ml average). Examination for C-loci specificity indicated that CW-1, CW-3 and CW-4 similar for both groups; however, the "low" IgE group had a frequency of 55.5% of recruits possessing CW-2 antigen compared with only 15% for the "high" group. The value for the "high" IgE appears to be similar to that of the normal population (10% incidence) and only slightly elevated when compared to 7% (2/29) found when the identical CW-2 antisera were tested with laboratory personnel. Thus the associations of HLA-CW2 with the recruits within the "low" IgE group suggests that this HLA marker may be an expression for a suppressed response for IgE immunoglobulin. Viral and bacterial infections, found frequently in these recruits, are discussed as a possible cause of this suppression.
mesh_terms: D006680:HLA Antigens; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis*; D008887:Military Medicine; D009674:Nova Scotia
chemical_list: D006680:HLA Antigens; D007073:Immunoglobulin E