Dopamine administration in the normotensive pregnant ewe.
Dopamine was administered to pregnant ewes at randomly selected rates of 1, 3, 5, 10, 20, 30, or 40 microgram/kg/min. Doses less than 10 microgram/kg/min produced no significant change in maternal areterial blood pressure, cardiac output, or renal or uterine blood flow. Higher doses increased maternal cardiac output and blood pressure, did not change renal blood flow, but decreased uterine blood flow. Dopamine consistently caused mild maternal and fetal respiratory acidosis.
D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D004298:Dopamine / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D007668:Kidney / Q000098:blood supply; D010100:Oxygen / Q000097:blood; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D012039:Regional Blood Flow / Q000187:drug effects; D012756:Sheep
D002245:Carbon Dioxide; D010100:Oxygen; D004298:Dopamine