[Metabolic study of Vincamine in cranial trauma (author's transl)].
The metabolic effects of Vincamine were studied in eight cases of cranial trauma. The lactate/pyruvate ratio in venous blood and cerebrospinal fluid was observed for a period of six hours immediately following intravenous injection of Pervincamine (1 mg/kg) and the results compared with values obtained in the six hours following injection of a placebo. The injections were administered in 20 minutes, at intervals of 24 hours. A statistically significant change was observed in the lactate/pyruvate ratio after injection of Pervincamine. No effect was observed after administration of the placebo.
D001930:Brain Injuries / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D004569:Electroencephalography; D007773:Lactates / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D010946:Plants, Medicinal; D011773:Pyruvates / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D014748:Vinca Alkaloids / Q000627:therapeutic use*
D007773:Lactates; D011773:Pyruvates; D014748:Vinca Alkaloids
Etude métabolique de la Vincamine chez les traumatisés crâniens.