Leukocyte counts in children with sickle cell disease. Comparative values in the steady state, vaso-occlusive crisis, and bacterial infection.
Total and differential WBC counts were measured in 88 children with sickle cell hemoglobinopathies during the steady state, vaso-occlusive crisis, and bacterial infection. Steady state leukocyte values were lower than anticipated on the basis of currently available information. Total and segmented leukocyte numbers were greatly increased during vaso-occlusive crisis and infection, but only with bacterial infection was there a consistent increase in bands or nonsegmented leukocytes (mean, 4,580/microliter). On the basis of these data we believe that total and differential leukocyte counts are of value for identifying those children with potentially serious bacterial infections.
D000293:Adolescent; D000745:Anemia, Hemolytic, Congenital / Q000097:blood; D000755:Anemia, Sickle Cell / Q000097:blood*; D001424:Bacterial Infections / Q000150:complications; D002452:Cell Count; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007962:Leukocytes / Q000473:pathology*; D007964:Leukocytosis / Q000150:complications; D012805:Sickle Cell Trait / Q000097:blood* / Q000150:complications