Further experience with mebendazole in the treatment of symptomatic trichuriasis in children.
Mebendazole (methyl-5-benzoylbenzimidazole-2-carbamate: Vermox), a broad spectrum anthelmintic, cured 22 (88%) children with symptomatic trichuriasis when given as a single 6-day course in a dosage of 100 mg twice daily. A further 3 (12%) were cured after a repeat 6-day course of therapy. Thus complete parasite eradication was achieved in all. The administration of an antidiarrheal agent, loperamide hydrochloride (Imodium), appeared to enhance the efficacy of mebendazole. Both drugs were well tolerated and completely free of any toxic effects.
D001196:Ascariasis / Q000150:complications; D001562:Benzimidazoles / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D006801:Humans; D007223:Infant; D008139:Loperamide / Q000627:therapeutic use; D008463:Mebendazole / Q000008:administration & dosage / Q000627:therapeutic use*; D014257:Trichuriasis / Q000188:drug therapy*
D001562:Benzimidazoles; D008139:Loperamide; D008463:Mebendazole