Regulation of gonadotropin secretion in Turner's syndrome.
To determine the role of body fat in regulating secretion of luteinizing hormone and follicle-stimulating hormone, we measured both at 20-minute intervals for 24 hours in eight children with Turner's syndrome. The 24-hour mean luteinizing hormone levels varied from 20.2 to 70.5 mlU per milliliter. Total body weight, total body fat and percentage of body fat showed a significant negative correlation with the 24-hour mean luteinizing hormone concentrations (P less than 0.01). The 24-hour mean follicle-stimulating hormone concentrations ranged from 60.4 to 229 mlU per milliliter, with a significant negative correlation between total body fat and percentage body fat and the 24-hour mean concentrations (P less than 0.05). These negative correlations were not mediated by estrogens or androgens.
D000273:Adipose Tissue; D000293:Adolescent; D000728:Androgens / Q000097:blood; D001823:Body Composition; D001834:Body Water; D001835:Body Weight; D002648:Child; D004967:Estrogens / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood / Q000378:metabolism*; D013997:Time Factors; D014424:Turner Syndrome / Q000097:blood / Q000503:physiopathology*
D000728:Androgens; D004967:Estrogens; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone