title: Protein and DNA levels in the submandibular salivary glands of isoproterenol stimulated mice.
abstract: The DNA and soluble and sedimental protein levels were studied in isoproterenol stimulated mouse submandibular salivary glands over a period of 200 h. Hypertrophy, the predominant cellular phenomenon following chronic isoproterenol treatment, was associated with a marked elevation of 14C-leucine incorporation into the buffer soluble protein fraction and a less pronounced isotope incorporation into the sedimental sub-cellular fraction as well as continued DNA synthesis. These findings are contrary to the accepted definitions of hypertrophy which preclude continued DNA synthesis. A suggestion is made, therefore, that in the system used the polyploidy associated with the hypertrophy involves.
mesh_terms: D000818:Animals; D004247:DNA / Q000096:biosynthesis*; D007545:Isoproterenol / Q000494:pharmacology*; D007930:Leucine / Q000378:metabolism; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D014176:Protein Biosynthesis; D013268:Stimulation, Chemical; D013347:Subcellular Fractions / Q000378:metabolism; D013363:Submandibular Gland / Q000187:drug effects* / Q000378:metabolism
chemical_list: D004247:DNA; D007930:Leucine; D007545:Isoproterenol