Antiextensor effects of 3,3-diphenyl-n-propylamine in the mouse.
Diphenylpropylamine has antiextensor activity in the MES test and worsens clonic seizures produced by pentylenetetrazol. The drug also prevents tonic hindlimb extension produced by large doses of pentylenetetrazol. Diphenylpropylamine appears, therefore, to be a phenytoin-like compound. However, unlike most antiextensor agents, diphenylpropylamine has neuroexcitatory effects and antagonizes barbital-induced loss of the righting reflex.
D000818:Animals; D001462:Barbital / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects*; D004347:Drug Interactions; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects*; D010424:Pentobarbital / Q000494:pharmacology; D010433:Pentylenetetrazole / Q000494:pharmacology; D011437:Propylamines / Q000494:pharmacology* / Q000633:toxicity; D012640:Seizures / Q000503:physiopathology; D012890:Sleep / Q000187:drug effects; D013997:Time Factors
D011437:Propylamines; D001462:Barbital; D010424:Pentobarbital; D010433:Pentylenetetrazole