m-Trifluoromethyl-alpha-ethylbenzhydrol: a new enzyme inducer.
The enzyme inducing effect of m-trifluoromethyl-alpha-ethylbenzhydrol (RGH-3332) has been studied in man, rat and mouse. In man, RGH-3332 decreased the half-life of antipyrine and tolbutamide and increased D-glucaric acid excretion. In rat and mouse the half-life of antipyrine was shortened. It was concluded that in all three species man, rat and mouse the liver microsomal drug metabolizing enzyme system was induced by RGH-3332. No side-effects were found on treatment with RGH-3332.
D000328:Adult; D000818:Animals; D000983:Antipyrine / Q000378:metabolism; D001559:Benzhydryl Compounds / Q000494:pharmacology*; D004790:Enzyme Induction / Q000187:drug effects*; D005260:Female; D005937:Glucaric Acid / Q000378:metabolism; D006207:Half-Life; D006801:Humans; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008875:Middle Aged; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D014044:Tolbutamide / Q000378:metabolism
D001559:Benzhydryl Compounds; D014044:Tolbutamide; C016914:flumecinol; D005937:Glucaric Acid; D000983:Antipyrine