An increased effect of pilocarpine on the pupil by application of the drug in oil.
In healthy volunteers pilocarpine in an oily solution had a greater degree and duration of effect on the pupil than the same amount of drug given in aqueous solution. Blue- and brown-eyed subjects had similar degrees of miosis, but the time taken to reach peak effects was longer with the latter. It can be concluded that eye drops made with an oily solvent may provide an improvement in the treatment of glaucoma with pilocarpine.
D000293:Adolescent; D000328:Adult; D005127:Eye Color; D005260:Female; D006801:Humans; D008297:Male; D009821:Oils; D010862:Pilocarpine / Q000008:administration & dosage* / Q000494:pharmacology; D011680:Pupil / Q000187:drug effects*; D012997:Solvents; D013997:Time Factors
D009821:Oils; D012997:Solvents; D010862:Pilocarpine