Drug absorption VIII: Kinetics of GI absorption of methotrexate.
The absorption of methotrexate from the lumen of the rat small intestine, in situ, was found to obey Michaelis--Menten kinetics. The values of Vmax and Km for the absorption process were 4.78 X 10(-7) M/min and 1.49 X 10(-5) M, respectively.
D000818:Animals; D007408:Intestinal Absorption; D007700:Kinetics; D008297:Male; D008727:Methotrexate / Q000378:metabolism*; D009994:Osmolar Concentration; D051381:Rats
D008727:Methotrexate