title: A thermographic assessment of three intra-articular prednisolone analogues given in rheumatoid synovitis.
abstract: 1 Three intra-articular prednisolone analogues have been studied in a group of forty-six rheumatoid arthritic subjects. Each compound was tested at 50 mg and 100 mg dose over 3 weeks. 2 The anti-inflammatory effect was assessed by quantitative thermography. Systemic escape of the drug was monitored by plasma prednisolone and cortisol levels. 3 Both the systemic escape from the joint and the duration of effect on injected and uninjected knees were related to drug solubility. 4 Depression of plasma cortisol occurred with all three preparations and was most prolonged with the long-acting preparation. 5 Increasing the dose from 50 mg to 100 mg increased the antiflammatory effect only with the soluble acetate preparation.
mesh_terms: D001172:Arthritis, Rheumatoid / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D001809:Blood Viscosity; D001831:Body Temperature; D006801:Humans; D011239:Prednisolone / Q000031:analogs & derivatives* / Q000097:blood / Q000627:therapeutic use; D013585:Synovitis / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology*; D013817:Thermography; D013997:Time Factors
chemical_list: D011239:Prednisolone