New 5-hydroxy-2-indolecarbohydrazides as platelet aggregation inhibitors in ethylene glycol.
The effect of ethylene glycol on blood platelet aggregation was examined using a previously described method. This method also was used to investigate several derivatives of 2-indolecarbohydrazide in vitro. All compounds inhibited platelet aggregation induced by collagen, epinephrine, or adenosine diphosphate at concentrations below 5 x 10(-4) M.
D005026:Ethylene Glycols / Q000494:pharmacology; D006801:Humans; D006834:Hydrazines / Q000494:pharmacology; D066298:In Vitro Techniques; D007211:Indoles / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D013329:Structure-Activity Relationship
D005026:Ethylene Glycols; D006834:Hydrazines; D007211:Indoles