Combined action of pyrazole and ethanol on a rat liver: histochemical and ultrastructural study.
The effect on a rat liver of combined administration of pyrazole and ethanol was studied histochemically and by electron microscopy. The study revealed strong hepatotoxic action of pyrazole combined with ethanol. Feeding with ethanol alone induces slight alterations in the liver, pyrazole alone affects the liver but slightly, whereas a combined administration of pyrazole and ethanol both by light and electron microscopy examination revealed a strong toxic action leading to severe damage of the liver cells including necrosis.
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D004357:Drug Synergism; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D008055:Lipids / Q000032:analysis; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000648:ultrastructure; D011720:Pyrazoles / Q000494:pharmacology*; D051381:Rats; D013385:Succinate Dehydrogenase / Q000378:metabolism
D008055:Lipids; D011720:Pyrazoles; D000431:Ethanol; D013385:Succinate Dehydrogenase; D000135:Acid Phosphatase