Influence of post-training intrahippocampally applied oxotremorine on the consolidation of a brightness discrimination.
The posttraining intrahippocampal injection of oxotremorine revealed an improvement of the retention performance in a brightness discrimination task. The oxotremorine effect seemed to be dependent on distinct variables of training and was restricted to rats exhibiting a good acquisition performance. Scopolamine impaired the retention performance of animals with few training errors. The role of hippocampal cholinergic synapses for consolidation was discussed.
D000818:Animals; D004192:Discrimination, Psychological / Q000187:drug effects*; D004343:Drug Implants; D004597:Electroshock; D006624:Hippocampus; D007267:Injections; D008027:Light; D008297:Male; D008568:Memory / Q000187:drug effects; D010095:Oxotremorine / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D004343:Drug Implants; D010095:Oxotremorine