Relations between hepatotoxicity and pharmacokinetics of paracetamol in rats and mice.
A dose-dependent increase of paracetamol serum half-life (t1/2) was found after oral and intravenous application in rats and oral application in mice. The hepatotoxic effects of paracetamol were not correlated with this prolongation of t1/2. Dithiocarb protected rats against paracetamol liver damage but did not change paracetamol t1/2. Paracetamol t1/2 was not influenced either by a hepatotoxic dose of carbon tetrachloride. In conclusion, the dose-dependent prolongation of paracetamol serum half-life is not due to paracetamol-induced liver damage but merely the consequence of saturated elimination processes.
D000082:Acetaminophen / Q000097:blood / Q000378:metabolism / Q000633:toxicity*; D000284:Administration, Oral; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury; D004305:Dose-Response Relationship, Drug; D006207:Half-Life; D007275:Injections, Intravenous; D008099:Liver / Q000187:drug effects*; D008297:Male; D051379:Mice; D051381:Rats; D013859:Thiocarbamates / Q000494:pharmacology
D013859:Thiocarbamates; D000082:Acetaminophen