title: Kinetics of early time calcium oxalate nephrolithiasis.
abstract: This paper examines the kinetics of calcium deposition in rat kidneys after an intraperitoneal sodium oxalate injection. From the results we conclude that only a limited portion of tubular surface is available for adsorption of calcium oxalate crystals, that adsorpption of calcium oxalate crystals onto tubular epithelium is a process of greater than first order with regard to the dose, and that the washout of retained particles from the tubules is a first-order process as related to time. Also, we conclude that in these animals, which were subjected to a large oxalate challenge, the deposition of calcium oxalate crystals is virtually all intratubular.
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D007668:Kidney / Q000378:metabolism* / Q000473:pathology; D007669:Kidney Calculi / Q000378:metabolism* / Q000473:pathology; D008297:Male; D010070:Oxalates / Q000378:metabolism* / Q000494:pharmacology; D051381:Rats; D012964:Sodium / Q000494:pharmacology
chemical_list: D010070:Oxalates; D012964:Sodium; D002118:Calcium