Effects of cephalexin, erythromycin and clindamycin on the aerobic Gram-negative faecal flora in man.
The effects of 5-day courses of orally administered cephalexin, clindamycin and erythromycin on the Gram-negative, aerobic faecal flora of healthy adults were examined. The concentration of cephalexin reached in the intestine was high enough to cause the emergence of resistant Gram-negative bacteria; organisms belonging to the genera Enterobacter, Citrobacter and Pseudomonas increased to easily detectable levels. The faecal concentration of erythromycin was high and caused a severe reduction of the coliform flora. Clindamycin administration resulted in a considerable increase in the coliform count; the increase in the proportion of klebsiellae was especially marked.
D000284:Administration, Oral; D002506:Cephalexin / Q000378:metabolism / Q000494:pharmacology*; D002954:Citrobacter / Q000254:growth & development; D002981:Clindamycin / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D004754:Enterobacter / Q000254:growth & development; D004917:Erythromycin / Q000378:metabolism / Q000494:pharmacology*; D005243:Feces / Q000382:microbiology*; D006088:Gram-Negative Aerobic Bacteria / Q000187:drug effects*; D006801:Humans; D011549:Pseudomonas / Q000254:growth & development
D002981:Clindamycin; D004917:Erythromycin; D002506:Cephalexin