Effect of theophylline on myocardial adenylate cyclase activity.
Theophylline (0.001-10.0 mM) did not increase but rather decrased adenylate cyclase activity (AC) of guinea-pig auricles. Isoprenaline (1-100 microgram) and sodium fluoride (0.3-10.0 mM) stimulated AC in a concentration-dependent manner.
D000067956:Adenylyl Cyclase Inhibitors; D000818:Animals; D005260:Female; D006168:Guinea Pigs; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009206:Myocardium / Q000201:enzymology*; D012969:Sodium Fluoride / Q000494:pharmacology; D013806:Theophylline / Q000494:pharmacology*
D000067956:Adenylyl Cyclase Inhibitors; D012969:Sodium Fluoride; D013806:Theophylline; D007545:Isoproterenol