Cocarcinogenic and irritant factors of Euphorbia esula L. latex.
The latex of (Euphorbia esula) has been found to contain highly skin irritant and inflammatory ingenol-3delta 2,4,6,8,10 pentene tetradecanoate and another factor, ingenol-3-dodecanoate, which is less irritating but which can be responsible for the cocarcinogenic activity exhibited by the latex preparation in the mice back skin experiment.
D000818:Animals; D003043:Cocarcinogenesis; D007509:Irritants / Q000633:toxicity*; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D010936:Plant Extracts / Q000633:toxicity*; D010947:Plants, Toxic
D007509:Irritants; D010936:Plant Extracts