3H-Apomorphine interactions with dopamine receptors in calf brain.
3H-apomorphine binds to membranes from areas of the corpus striatum and limbic system of calf brain saturable and with a drug specificity indicating that it labels dopamine receptors. In terms of drug specificity, log-logit displacement curve slopes and number of binding sites, 3H-apomorphine interacts with receptors in a manner more like 3H-dopamine than 3H-haloperidol. These properties of 3H-apomorphine binding are those of an apparently "pure" agonist in contrast to the partial agonist effects of apomorphine upon the dopamine-sensitive adenylate cyclase.
D000818:Animals; D001058:Apomorphine / Q000378:metabolism*; D001667:Binding, Competitive; D001921:Brain / Q000378:metabolism*; D002417:Cattle; D004298:Dopamine / Q000378:metabolism / Q000502:physiology; D018492:Dopamine Antagonists; D006220:Haloperidol / Q000378:metabolism; D066298:In Vitro Techniques; D011954:Receptors, Dopamine / Q000378:metabolism*
D018492:Dopamine Antagonists; D011954:Receptors, Dopamine; D006220:Haloperidol; D001058:Apomorphine; D004298:Dopamine