Tumorigenic effect of an organomanganese compound on F344 rats and Swiss albino mice.
Trioctanoin suspensions of manganese dioxide and manganese powder were injected im into inbred F344 rats and Swiss albino mice. The manganese powder was also administered orally to the rats. No difference in tumor incidence was noted between treated and control animals. In contrast, manganese (manganous) acetylacetonate administered im to rats produced a statistically significant number of fibrosarcomas at the sites of injection.
D000818:Animals; D002273:Carcinogens; D005260:Female; D005354:Fibrosarcoma / Q000139:chemically induced; D007273:Injections, Intramuscular; D008297:Male; D008345:Manganese / Q000008:administration & dosage; D017895:Manganese Compounds; D020149:Manganese Poisoning; D051379:Mice; D009942:Organometallic Compounds / Q000633:toxicity*; D010087:Oxides / Q000008:administration & dosage / Q000633:toxicity; D010422:Pentanones / Q000008:administration & dosage / Q000633:toxicity; D051381:Rats; D011916:Rats, Inbred F344; D012513:Sarcoma, Experimental / Q000139:chemically induced*
D002273:Carcinogens; D017895:Manganese Compounds; D009942:Organometallic Compounds; D010087:Oxides; D010422:Pentanones; D008345:Manganese; C016552:manganese dioxide