Role of phosphatidylcholine on microsomal chain elongation and the fate of stearoyl-CoA in rat liver microsomes.
The effect of phosphatidylcholine dispersion on the chain elongation of palmitoyl-CoA in rat liver microsomes has been investigated. Addition of phosphatidylcholine increased the formation of stearic acid and its incorporation into phosphatidylcholine. In the presence or absence of phosphatidylcholine, newly-formed stearic acid was preferentially incorporated into the C-1 position of phosphatidylcholine. The incorporation of newly formed stearic acid into microsomes was much higher than that into the added phosphatidylcholine dispersion.
D000214:Acyl Coenzyme A / Q000378:metabolism*; D000818:Animals; D050356:Lipid Metabolism; D008316:Malonyl Coenzyme A / Q000378:metabolism; D008862:Microsomes, Liver / Q000378:metabolism*; D010171:Palmitoyl Coenzyme A / Q000378:metabolism; D010713:Phosphatidylcholines / Q000378:metabolism*; D051381:Rats; D013229:Stearic Acids / Q000378:metabolism
D000214:Acyl Coenzyme A; D010713:Phosphatidylcholines; D013229:Stearic Acids; D010171:Palmitoyl Coenzyme A; C017725:stearoyl-coenzyme A; D008316:Malonyl Coenzyme A