[Intensity of the metabolism of separate brain phospholipid fractions in hyperphenylalaninemia].
Effect of acute and chronic forms of hyperphenylalaninemia on intensity of metabolism and content of some phospholipid fractions was studied in brain of growing rats. Acute form of hyperphenylalaninemia caused a decrease in metabolic activity of phospholipids but did not affect their content. In chronic hyperphenylalaninemia more distinct alterations in brain phospholipids metabolism were manifested as a decrease in their content and in their metabolic intensity. The data obtained suggest that brain demyelination developed in chronic hyperphenylalaninemia.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D003711:Demyelinating Diseases / Q000378:metabolism; D010649:Phenylalanine / Q000097:blood*; D010743:Phospholipids / Q000032:analysis / Q000378:metabolism*; D051381:Rats
D010743:Phospholipids; D010649:Phenylalanine
Intensivnost' obmena otdel'nykh fraktsiĭ fosfolipidov mozga pri giperfenilalaninemii.