[Postcoital contraception in primates. I. Action mechanism of a potential postovulatory fertility-inhibiting substance STS 456 in the baboon (Papio hamadryas)].
With the substance STS 456, an estrogenic active steroid, a high fertility inhibition could be obtained in the pavian, when administered p. o. over a 5 day period postcoital. The effectiveness and also the side effects were dose dependent. The antifertility mechanism is based on an luteolytic effect, demonstrated by analytical hormonal investigations. The inhibition of the synthesis of steroids in the ovary affected not only progesterone but also the estrogens.
D000818:Animals; D003281:Contraceptives, Postcoital / Q000494:pharmacology*; D003282:Contraceptives, Postcoital, Hormonal / Q000008:administration & dosage / Q000494:pharmacology*; D004967:Estrogens / Q000096:biosynthesis; D005260:Female; D005298:Fertility / Q000187:drug effects*; D010053:Ovary / Q000187:drug effects / Q000378:metabolism; D010215:Papio / Q000502:physiology*; D011374:Progesterone / Q000096:biosynthesis; D013045:Species Specificity
D003281:Contraceptives, Postcoital; D003282:Contraceptives, Postcoital, Hormonal; D004967:Estrogens; D011374:Progesterone
Postkoitale Kontrazeption bei Primaten. I. Zum Wirkungsmechanismus einer potentiellen postovulatorisch fertilitätshemmenden Substanz STS 456 beim Pavian (Papio hamadryas)