title: Phenoxybenzamine in neurogenic bladder dysfunction after spinal cord injury. II. Autonomic dysreflexia.
abstract: Phenoxybenzamine blockade of the alpha receptor site can abolish the vascular and internal sphincter responses in patients with chronic recurrent autonomic dysreflexia associated with bladder filling or contraction. The life-threatening hypertensive response is suppressed by this medication. Therefore, the drug is a beneficial adjunct in the pharmacologic management of autonomic dysreflexia. When the drug is used patients can be maintained free of a catheter. The drug had no serious side effects at the dose regimen used. One particularly significant advantage is its long duration of action--patients occasionally can skip doses of medication and not suffer acute symptoms.
mesh_terms: D001341:Autonomic Nervous System; D002908:Chronic Disease; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008297:Male; D009422:Nervous System Diseases / Q000188:drug therapy / Q000209:etiology; D010643:Phenoxybenzamine / Q000627:therapeutic use*; D012021:Reflex, Abnormal / Q000188:drug therapy / Q000209:etiology; D013119:Spinal Cord Injuries / Q000150:complications*; D013546:Sweating; D001750:Urinary Bladder, Neurogenic / Q000188:drug therapy / Q000209:etiology
chemical_list: D010643:Phenoxybenzamine