The pathogenesis of congenital hereditary lymphedema in the pig.
The morphogenesis of congenital hereditary lymphedema was studied in pigs. The disorder, which is essentially a general underdevelopment or even total non-development of the lymphatic system proved to be present during the whole period of lymphatic development. It is suggested that a retardation in the differentiation of the lymphatic primordia from the primitive veins is the early event regulated by a chromosomal aberration. The longer this delay the more serious the lymphatic malformations.
D000818:Animals; D008208:Lymphatic System / Q000196:embryology; D008209:Lymphedema / Q000151:congenital / Q000196:embryology / Q000473:pathology / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000151:congenital / Q000196:embryology* / Q000473:pathology