Prostaglandin-induced eosinopenia in splenectomized rats.
PGE1, PGE2, and PGF2alpha over a dose range of 1 to 50 microgram/kg decreased the number of circulating eosinophils in splenectomized rats. Pretreatment with a beta-blocking agent, propranolol, did not alter this effect, but adrenalectomy eliminated it. Anterior hypothalamic destruction also abolished eosinopenia induced by PGE1 and PGF2alpha but not that induced by PGE2.
D000315:Adrenalectomy; D000818:Animals; D004804:Eosinophils; D004837:Epinephrine / Q000494:pharmacology; D007032:Hypothalamus, Anterior / Q000502:physiology; D007958:Leukocyte Count; D007970:Leukopenia / Q000503:physiopathology*; D008297:Male; D011433:Propranolol / Q000494:pharmacology; D011453:Prostaglandins / Q000502:physiology*; D011458:Prostaglandins E / Q000494:pharmacology; D011460:Prostaglandins F / Q000494:pharmacology; D051381:Rats; D013156:Splenectomy
D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; D011433:Propranolol; D004837:Epinephrine