[Effect of normal and leukemic leukocytes on blood coagulation and fibrinolysis].
Lysates of leukocytes of healthy persons and of patients with acute and chronic leukemias possess a weak tissue factor activity. This procoagulant activity is increased greatly when leukocytes are stimulated by endotoxin. The tissue factor is derived almost exclusively from the monocytes and not from lymphocytes and granulocytes. Monocytes are stimulated to the same extent by adherence to plastic surfaces. The fibrinolytic activity of lysates of mixed leukocytes is due to a nonspecific protease and a plasminogen activator. Only granulocytes can cause fibrinolyses. Endotoxin stimulation enhances the plasminogen activator but not the protease. Normal leukocytes and leukocytes of patients with chronic leukemias also exert an antithrombin activity.
D001777:Blood Coagulation; D004211:Disseminated Intravascular Coagulation / Q000097:blood; D004731:Endotoxins / Q000494:pharmacology; D005342:Fibrinolysis; D006801:Humans; D007938:Leukemia / Q000097:blood*; D007962:Leukocytes / Q000201:enzymology; D009000:Monocytes / Q000201:enzymology; D013917:Thrombin / Q000037:antagonists & inhibitors; D013925:Thromboplastin
D004731:Endotoxins; D013925:Thromboplastin; D013917:Thrombin
Beeinflussung von Blutgerinnung und Fibrinolyse durch normale und leukämische Leukozyten.