title: Perinatal development of, and effect of chemical pretreatment on, glycine N-acyltransferase activities in liver and kidney of rabbit and rat.
abstract: The ontogenic development of glycine N-acyltransferase activity was studied in preparations of hepatic and renal mitochondria from the New Zealand White rabbit and the Sprague-Dawley rat. Preparations of hepatic mitochondria from the rat and the rabbit attain adult glycine N-acyltransferase specific activities by birth and 4 weeks of age respectively, whereas mitochondrial preparations from rabbit kidney do not attain adult activity until 4 months of age. Pretreatment of adult rats or immature rabbits with salicylic acid, benzoic acid or phenobarbital had little effect on glycine N-acyltransferase activity in vitro in liver or kidney.
mesh_terms: D000217:Acyltransferases / Q000378:metabolism*; D000818:Animals; D001565:Benzoates / Q000494:pharmacology; D005260:Female; D005998:Glycine; D006128:Growth; D007668:Kidney / Q000187:drug effects / Q000201:enzymology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D008928:Mitochondria / Q000201:enzymology; D008930:Mitochondria, Liver / Q000201:enzymology; D010634:Phenobarbital / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D012459:Salicylates / Q000494:pharmacology
chemical_list: D001565:Benzoates; D012459:Salicylates; D000217:Acyltransferases; D005998:Glycine; D010634:Phenobarbital