Rheumatoid synovial cells in culture produce a growth inhibitor.
Cultures of synovial cells obtained at surgery from patients with rheumatoid arthritis produced a protein which inhibits the mitosis of normal rabbit and human synovial cells, and of human lung fibroblasts. This mitotic inhibitory effect can be transferred to rabbit synovial cells by intra-articular injection of the animals with rheumatoid synovial cell cultures.
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000378:metabolism*; D002457:Cell Extracts / Q000494:pharmacology; D002478:Cells, Cultured; D006801:Humans; D008938:Mitosis / Q000187:drug effects; D011506:Proteins / Q000378:metabolism*; D011817:Rabbits; D013582:Synovial Fluid / Q000378:metabolism*
D002457:Cell Extracts; D011506:Proteins