title: Activity of alcohol dehydrogenase and acetaldehyde dehydrogenases in the liver and placenta during the development of the rat.
abstract: The ontogenetic development of the enzymes alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenases (ALDH I and II) was followed in rats. ADH could be detected just before birth and increased gradually to reach 82% of adult values at 47 days. ALDH I and II were present from day 15 of gestation, increased rapidly at birth, and reached 80-90% adult values at 47 days. The ratio between ALDH and ADH activities decreased gradually during ontogenesis. The relative subcellular distribution of all enzymes was identical before birth, 7 days after birth and in adults. The placental activities of ADH and ALDH I and II were studied at 15 and 20 days of pregnancy. ADH could not be detected in placentas. Low activities of ALDH I and II were present in placentas studied at 15 days of gestation, and still lower activities were found in placenta at 20 days.
mesh_terms: D000079:Acetaldehyde; D000429:Alcohol Oxidoreductases / Q000378:metabolism*; D000445:Aldehyde Oxidoreductases / Q000378:metabolism*; D000818:Animals; D005260:Female; D005865:Gestational Age; D008099:Liver / Q000196:embryology / Q000201:enzymology* / Q000254:growth & development; D010920:Placenta / Q000201:enzymology*; D011247:Pregnancy; D051381:Rats; D013347:Subcellular Fractions / Q000201:enzymology
chemical_list: D000429:Alcohol Oxidoreductases; D000445:Aldehyde Oxidoreductases; D000079:Acetaldehyde