[Thrombolytic action of a heparin-ocrase complex].
The thrombolytic action of the complex heparin-ocrase on the experimentally formed fresh thrombi obtained through intravenous introduction of thrombin into an isolated length of the jugular vein was compared against the effect produced on the thrombi by equivalent amounts of individual components of the complex, i.e. heparin and ocrase. Investigations revealed a lysis of experimental fresh thrombi after intravenous injections of the complex heparin-ocrase and this lysis supervened quicker than following the action of equivalent amounts of ocrase. Heparin used in a dose equivalent to its content in the complex did, as this has been presumed, exercise no thrombolytic action at all.
D000818:Animals; D001230:Aspergillus / Q000201:enzymology*; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D005342:Fibrinolysis / Q000187:drug effects; D005343:Fibrinolytic Agents; D006493:Heparin / Q000494:pharmacology*; D008297:Male; D010447:Peptide Hydrolases; D051381:Rats; D013927:Thrombosis / Q000188:drug therapy; D013997:Time Factors
D004338:Drug Combinations; D005343:Fibrinolytic Agents; D006493:Heparin; D010447:Peptide Hydrolases; C021901:ocrase
Tromboliticheskoe deĭstvie kompleksa geparin-okraza.