USP dissolution III: semilogarithmic dissolution patterns of tablets in rotating-basket assemblies.
The dissolution of a rapidly soluble, finely subdivided substance in a directly compressed tablet and in a wet granulated tablet was treated experimentally and compared with previous theoretical models. The dissolution curves were sigmoid with a semilogarithmic tail when concentration was plotted versus time. As predicted, the slope of the semilogarithmic plots were related to the disintegration decay constant for tablet erosion in the basket.
D008956:Models, Chemical; D010602:Pharmacopoeias as Topic; D012995:Solubility; D013607:Tablets; D013678:Technology, Pharmaceutical; D014481:United States
D013607:Tablets