title: Four cases of chromosome changes detected in course of prenatal diagnosis and probably originating in vitro.
abstract: In a series of 1000 prenatal diagnoses, four cases were found with chromosome changes. The probable in vitro origin of these changes was demonstrated by starting several parallel cultured simultaneously and by repeating the amniocenteses and chromosome analyses.
mesh_terms: D000328:Adult; D000649:Amniocentesis; D002478:Cells, Cultured; D002869:Chromosome Aberrations / Q000175:diagnosis*; D025063:Chromosome Disorders; D003951:Diagnostic Errors; D005260:Female; D006801:Humans; D007621:Karyotyping; D011247:Pregnancy; D011296:Prenatal Diagnosis