Hyperglucagonemia and hepatic ketogenesis in burned swine.
A porcine burn model demonstrates hypoglycemia in spite of hyperglucagonemia. The ketone response to free fatty acids is defined for the normal and burned pig. Ketogenesis is augmented beyond that expected from free fatty acids during the postburn period. These metabolic changes may be related to the hyperglucagonemia and/or the relative hypoinsulinemia observed in the burned pig.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002056:Burns / Q000378:metabolism*; D004195:Disease Models, Animal; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005934:Glucagon / Q000097:blood*; D006493:Heparin / Q000494:pharmacology; D007328:Insulin / Q000097:blood; D007659:Ketones / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D009132:Muscles / Q000378:metabolism; D013552:Swine / Q000378:metabolism*
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D007659:Ketones; D006493:Heparin; D005934:Glucagon