Comparative pharmacology of the optical isomers of ketamine in mice.
Relative pharmacological potencies of the optical isomers of ketamine have been estimated in ICR mice. The (+)-isomer was 3X more potent than (-)-ketamine as an analgesic using the phenylquinone writhing test, only 1.5X more potent in terms of hypnotic activity and 1.8X more potent in causing locomotor stimulation. At equianalgesic doses (+)-ketamine caused less stimulation of locomotor activity than the (-)-isomer. These potency differences did not appear to be due to differences in biodisposition although stereoselective metabolism was demonstrated in vivo. Analgesia induced by ketamine was reversed by 10 mg/kg of naloxone.
D000700:Analgesics; D000818:Animals; D001711:Biotransformation; D001921:Brain / Q000378:metabolism; D006993:Hypnotics and Sedatives; D007649:Ketamine / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects; D009270:Naloxone / Q000494:pharmacology; D013237:Stereoisomerism; D013997:Time Factors
D000700:Analgesics; D006993:Hypnotics and Sedatives; D009270:Naloxone; D007649:Ketamine