Liver glycogen synthesis and glucose tolerance in rats adapted to diets with a high proportion of fructose or glucose.
Glucose tolerance and in vivo incorporation of glucose into liver glycogen were investigated in rats fed high carbohydrate diets containing glucose or fructose as the sole carbohydrate source. As compared with control glucose-adapted rats, a slight deterioration of the glucose tolerance was observed in fructose-adapted rats. The possivle cause of the deteriorated glucose tolerance in fructose-adapted rats seems to be among others reduced glucose incorporation into liver glycogen and a smaller depression of endogenous glucose production by exogenous glucose.
D000222:Adaptation, Physiological; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D004040:Dietary Carbohydrates / Q000378:metabolism*; D005260:Female; D005632:Fructose / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D005951:Glucose Tolerance Test; D008112:Liver Glycogen / Q000096:biosynthesis*; D051381:Rats
D001786:Blood Glucose; D004040:Dietary Carbohydrates; D008112:Liver Glycogen; D005632:Fructose; D005947:Glucose