title: Presence of erythropoiesis inhibitor in the urine of normal sheep and those with transfused polycythemia.
abstract: Presence of erythropoiesis inhibitor in the urine of normal sheep and those with transfused polycythaemia. Acta Physiol. Pol., 1978, 29 (1): 37-46. Urine from 18 ewes, normal and with transfused polycythemia, was analysed. The consequences of polycythemia were estimated in the period between 96 and 192h. The 24 h urine portions were separated on Sephadex G 100 columns, and after dialysis, tested biologically on normal mice of the BALB/c and Swiss strains. Changes of the erythropoietic activity in normal mice receiving the particular plasma fractions demonstrated that in the urine fraction IV, a factor with activity characteristic for the erythropoiesis inhibitor, is present in most normal sheep and in all those with moderate polycythemia.
mesh_terms: D000818:Animals; D004920:Erythropoiesis / Q000187:drug effects; D004921:Erythropoietin / Q000037:antagonists & inhibitors*; D011086:Polycythemia / Q000097:blood* / Q000652:urine; D012756:Sheep
chemical_list: D004921:Erythropoietin