Effect of abdominal vagotomy of the pregnant rat on LH and progesterone concentrations and fetal resorption.
Abdominal vagotomy on Day 8 of pregnancy in rats decreased the number of live fetuses at Day 16 and increased the number of resorbing fetuses. The activity of delta5-3beta-hydroxysteroid dehydrogenase (3beta-HSD) in the corpus luteum and interstitial gland, LH and progesterone values in plasma and progesterone values in ovarian tissue were all lower in vagotomized rats than in sham-operated controls. Ovarian PGF levels were not affected. We suggest that these effects were caused by a direct effect of vagotomy on LH secretion which in turn lowers 3beta-HSD activity and progesterone levels in ovarian tissue and plasma, leading to fetal resorption.
D000818:Animals; D005260:Female; D005313:Fetal Death; D005327:Fetal Resorption; D006651:Histocytochemistry; D007986:Luteinizing Hormone / Q000097:blood*; D010053:Ovary / Q000294:innervation / Q000378:metabolism; D011247:Pregnancy; D011374:Progesterone / Q000378:metabolism*; D011460:Prostaglandins F / Q000378:metabolism; D051381:Rats; D014628:Vagotomy
D011460:Prostaglandins F; D011374:Progesterone; D007986:Luteinizing Hormone