New spectrophotofluorometric assay for probenecid.
A new spectrophotofluorometric assay for probenecid is presented based on conversion of the drug to a fluorescent anthranilic acid derivative. The assay is especially applicable with "clean" biological fluids such as cerebrospinal fluid and offers severalfold greater sensitivity than the commonly used UV method.
D000818:Animals; D004285:Dogs; D008297:Male; D008722:Methods; D011339:Probenecid / Q000032:analysis*; D013050:Spectrometry, Fluorescence; D013997:Time Factors
D011339:Probenecid