The inhibitory effects of a dermal extract upon granulation tissue.
Injection of a water-soluble dermal extract into adult rats resulted in depression of DNA synthesis in granulation tissue at 3 different sites of injury, but not in epithelium. This suggests that connective tissue proliferation may be controlled in part by a chalone-like mechanism.
D000818:Animals; D004247:DNA / Q000096:biosynthesis; D004848:Epithelium / Q000378:metabolism; D006097:Granulation Tissue / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D012867:Skin; D014020:Tissue Extracts / Q000494:pharmacology
D014020:Tissue Extracts; D004247:DNA