Long-term depression of two primary immune responses induced by a single dose of 5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamide (DTIC).
2 primary immune responses (anti-SRBC antibody response and allograft rejection) have been tested in mice at various time intervals after single doses of either DTIC or cyclophosphamide. The DTIC-induced immunodepression proved to be extremely long-lasting, being still detectable after 2 months.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D003520:Cyclophosphamide / Q000494:pharmacology; D003606:Dacarbazine / Q000494:pharmacology*; D005260:Female; D006084:Graft Rejection / Q000187:drug effects; D007166:Immunosuppressive Agents; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation; D014226:Triazenes / Q000494:pharmacology*
D007166:Immunosuppressive Agents; D014226:Triazenes; D003606:Dacarbazine; D003520:Cyclophosphamide