Antagonism of the effects on thermoregulation of delta9-tetrahydrocannabinol by clomipramine in the rat.
1 The effect of pretreatment with clomipramine hydrochloride (15 mg/kg, i.p.) on the (--)-trans-delta9-tetrahydrocannabinol (delta9-THC)-induced changes in body temperature and brain amines of the rat was investigated. 2 A dose of 0.05 mg/kg of delta9-THC produced hyperthermia and a decrease in whole brain concentration of 5-hydroxyindoleacetic acid (5-HIAA). Doses of 2 and 5 mg/kg produced hypothermia and increases in brain 5-HIAA whereas 0.5 mg/kg did not affect either parameter. delta9-THC, at any of the doses, did not affect the whole brain concentrations of dopamine, noradrenaline or 5-hydroxytryptamine. 3 Clomipramine modified these responses of delta9-THC in that the dose-response curves appeared to be shifted to the right. 4 It is concluded that clomipramine acts as an antagonist to these actions of delta9-THC by interfering with entry of delta9-THC into tryptaminergic neurones.
D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism; D001833:Body Temperature Regulation / Q000187:drug effects*; D001923:Brain Chemistry / Q000187:drug effects; D002997:Clomipramine / Q000494:pharmacology*; D003984:Dibenzazepines / Q000494:pharmacology*; D013759:Dronabinol / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats
D001679:Biogenic Amines; D003984:Dibenzazepines; D013759:Dronabinol; D002997:Clomipramine