Phenoxybenzamine in neurogenic bladder dysfunction after spinal cord injury. I. Voiding dysfunction.
Phenoxybenzamine is a welcomed adjunct in the pharmacologic management of patients with neurogenic bladder dysfunction resulting from spinal cord trauma. Side effects are infrequent. Bladder balance was predictably and effectively achieved and maintained in patients with 1) lower motor neuron lesions, 2) upper motor neuron lesions and coexisting autonomic dysreflexia and 3) intact sympathetic innervation and upper motor neuron bladders. The response was unpredictable in patients with upper motor neuron lesions without coexisting dysreflexia.
D000320:Adrenergic Fibers / Q000187:drug effects; D006801:Humans; D008297:Male; D009046:Motor Neurons / Q000187:drug effects; D010643:Phenoxybenzamine / Q000627:therapeutic use*; D011859:Radiography; D012021:Reflex, Abnormal / Q000188:drug therapy; D013119:Spinal Cord Injuries / Q000150:complications*; D014521:Urethra / Q000294:innervation; D001743:Urinary Bladder / Q000294:innervation; D001748:Urinary Bladder Neck Obstruction / Q000000981:diagnostic imaging / Q000209:etiology; D001750:Urinary Bladder, Neurogenic / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D014554:Urination / Q000187:drug effects*
D010643:Phenoxybenzamine