Histamine in nasal secretions.
The histamine content of secretions collected by small-volume nasal washes was assayed by a spectrophotofluorometric method. A wide range of histamine concentrations (less than 5-1,519 ng/ml) was found. The mean concentration in secretions from normal individuals (91 ng/ml) was not significantly different from that found in allergic individuals (51 ng/ml). Females had significantly lower concentrations than did males. Sequential sampling in normals and allergics showed a great deal of daily variation in histamine content. This technically simple method may prove useful in examining the epidemiology and pathophysiology of allergic rhinitis.
D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000378:metabolism; D005260:Female; D006632:Histamine / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D008297:Male; D009093:Mucus / Q000032:analysis*; D009297:Nasal Mucosa / Q000378:metabolism*; D006255:Rhinitis, Allergic, Seasonal / Q000378:metabolism*; D012737:Sex Factors; D013050:Spectrometry, Fluorescence
D006632:Histamine