Platelet aggregation and adhesiveness as well as blood lipids level in dogs treated with di-(1-isoquinolinyl)-di-(pyridyl-2')-butane and carbocromen.
The effect of di-(1-isoquinolinyl)-di-(pyridyl-2')-butane (S-147) on platelet aggregation and adhesiveness as well as on blood lipids level (total lipids, triglycerides, total cholesterol) was tested in mongrel dogs, in comparison with carbocromen. The compounds administered iv (2 mg/kg/day) over 7 days inhibited ADP-induced aggregation, being without depressive influence on platelet adhesiveness. S-147 exhibited slightly stronger effect than carbocromen. The inhibition of platelet aggregation was accompanied by the decrease of serum lipids level.
D000818:Animals; D002784:Cholesterol / Q000097:blood; D002866:Chromonar / Q000494:pharmacology*; D003374:Coumarins / Q000494:pharmacology*; D003864:Depression, Chemical; D004285:Dogs; D007546:Isoquinolines / Q000494:pharmacology*; D008055:Lipids / Q000097:blood*; D008297:Male; D010973:Platelet Adhesiveness / Q000187:drug effects; D010974:Platelet Aggregation / Q000187:drug effects*; D011725:Pyridines / Q000494:pharmacology; D014280:Triglycerides / Q000097:blood
D003374:Coumarins; D007546:Isoquinolines; D008055:Lipids; D011725:Pyridines; D014280:Triglycerides; C016847:di-(1-isoquinolinyl)-di-(pyridyl-2')butane; D002784:Cholesterol; D002866:Chromonar