title: Myocardial protection during ischemic cardiac arrest. The importance of magnesium in cardioplegic infusates.
abstract: The increasing use of coronary infusates for the protection of the human heart drug ischemic cardiac arrest has placed great emphasis on the need for a rational and safe formulation of any infusion solution. Using a rat heart model of cardiopulmonary bypass and ischemic cardiac arrest, we have found magnesium to be a highly effective component of protective infusates which can be additive to hypothermia and other protective agents. However, the concentration of magnesium bears a complex relationship to the degree of protection, a fact which stresses the need for the establishment of the correct concentration for optimal protection.
mesh_terms: D000818:Animals; D001794:Blood Pressure; D001831:Body Temperature; D002712:Chlorides / Q000494:pharmacology; D003326:Coronary Circulation; D004305:Dose-Response Relationship, Drug; D006324:Heart Arrest, Induced / Q000379:methods*; D006339:Heart Rate; D007036:Hypothermia, Induced; D008278:Magnesium Sulfate / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D010477:Perfusion; D051381:Rats; D013997:Time Factors
chemical_list: D002712:Chlorides; D008278:Magnesium Sulfate