[Alterations of systolic and electrocardiographic time intervals in normal patients by Ro 11-1781, a new calcium-antagonist (author's transl)].
Five minutes following intravenous application of calcium antagonist Ro 11-1781 (1 mg/kg BDW) PQ duration increased significantly in 10 healthy volunteers without more severe atrioventricular conduction disturbances. Both, systolic and diastolic blood pressure decreased and heart rate increased significantly. Left ventricular ejection time (LVET) and the time from the beginning of QRS to the first sound (QS1) did not change in contrast to a significant decrease of the electromechanical systolic interval (QS2) and of the total pre-ejection-period (PEP). The decrease in PEP is explained by a decrease in isovolumic contraction time (IVCT). This can be regarded in connection with a decreased PEP/LVET-ratio, an expression of better heart performance. In spite of the negative inotropic effect of the calcium antagonist Ro 11-1781, our results point to an increase in left ventricular performance and in heart rate caused by an exaggerated sympathic reaction to a fall in blood pressure.
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002118:Calcium / Q000037:antagonists & inhibitors*; D003864:Depression, Chemical; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006571:Heterocyclic Compounds / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects*; D013997:Time Factors
D006571:Heterocyclic Compounds; D002118:Calcium
Die Beeinflussung systolischer und elektrokardiographischer Zeitintervalle herzgesunder Patienten durch den Kalziumantagonisten Ro 11-1781.