title: Reward, attention and the dorsal noradrenergic bundle.
abstract: The resistance to extinction seen after lesion to the dorsal noradrenergic bundle has been suggested to arise from a deficit in internal inhibition or a 'perseverative' type of deficit. This hypothesis is tested by examining the ability of 6-hydroxydopamine-treated animals to inhibit a previously developed preference for saccharine solution as a result of poisoning with lithium chloride. Unimpaired taste aversion is found, arguing against a deficit in the ability to inhibit a prepotent response. An alternative explanation of the dorsal bundle extinction effect (DBEE), that of alterations in attention, is tested by acquisition and reversal of a successive light-dark discrimination. Both acquisition and reversal are severely impaired, suggesting that the treated animals have difficulty in attending to a specific stimulus in the environment when this is required in order to structure behaviour appropriately, and thus being consistent with a role for the dorsal bundle in the control of attentional processes.
mesh_terms: D000320:Adrenergic Fibers / Q000502:physiology*; D000818:Animals; D001288:Attention / Q000502:physiology*; D001362:Avoidance Learning / Q000502:physiology; D004193:Discrimination Learning / Q000502:physiology; D004298:Dopamine / Q000502:physiology; D005108:Extinction, Psychological / Q000502:physiology; D006624:Hippocampus / Q000502:physiology; D007031:Hypothalamus / Q000502:physiology; D008125:Locus Coeruleus / Q000502:physiology*; D008297:Male; D009433:Neural Inhibition; D009434:Neural Pathways / Q000502:physiology; D009638:Norepinephrine / Q000502:physiology*; D051381:Rats; D012201:Reward; D013687:Telencephalon / Q000502:physiology*; D014796:Visual Perception / Q000502:physiology
chemical_list: D004298:Dopamine; D009638:Norepinephrine