[Computer analysis of the EEG as an aid in terminating diet therapy in phenylketonuria].
In 6 patients with PKU, being on a low phenylalanine diet, the effect of reintroduction of phenylalanine on the E.E.G. was studied. The children, therefore, received daily loads of 100 or 150 mg phenylalanine/Kg bodyweight, equally divided over the meals. Computerized spectral analysis of the E.E.G's was performed during and after the loading tests. This made quantification possible of the following E.E.G. changes: 1) the increase of activities in the theta frequency band (4-8 Hz); 2) the frequency change of the alpha rhythm; 3) the change of the degree of synchrony between identical frequencies occurring in different derivations. A linear relation was found between these quantified E.E.G. parameters and the phenylalanine blood-level. After stopping the loading test E.E.G. abnormalities reversed suggesting that they could be considered as a measure for the degree of intoxication caused by the phenylalanine and/or its metabolites. It is suggested that the E.E.G. data may be useful parameters for alleviation or termination of the diet.
D000513:Alpha Rhythm; D002540:Cerebral Cortex / Q000503:physiopathology; D002648:Child; D003201:Computers; D004569:Electroencephalography / Q000379:methods*; D005069:Evaluation Studies as Topic; D006801:Humans; D010649:Phenylalanine / Q000097:blood; D010661:Phenylketonurias / Q000178:diet therapy* / Q000503:physiopathology; D013826:Theta Rhythm
D010649:Phenylalanine
Analyse d'E.E.G. par calculateur pour définir l'arrêt du traitement diététique des phénylcétonuries.