In vitro evaluation of a semisynthetic derivative of gentamicin B (Sch 21420).
The activities of Sch 21420 and amikacin were compared in vitro against 448 clinical bacterial isolates and against 82 gentamicin-resistant isolates of gram-negative bacilli. At 1 mug/ml, Sch 21420 was more active than amikacin against most Enterobacteriaceae but less active against Pseudomonas aeruginosa. Activity of these antibiotics against gentamicin-resistant organisms varied according to the species examined.
D000583:Amikacin / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D005839:Gentamicins / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests
D005839:Gentamicins; D000583:Amikacin