[Cysteine activity in the poisoning of animals by various aliphatic series halogenated hydrocarbons].
In poisoning animals with various aliphatic series haloid-hydrocarbons (LK99 and LD99) free cysteine was found to be a group antidote in rats poisoned with monohaloid-hydrocarbons. It was established that the therapeutic activity of cystein depends not on the nature of haloid and double bonds, but on the number of the haloid atoms in a molecule, the length, ramification and nature of the radical. A good durative action are shown by such cystein derivatives as acetyl-cysteine, glutathione and cystein salts. In poisoning with haloid-alkyls dithiol antidotes (unithiol, mecaptide, BAL) and other drugs proved ineffective.
D000111:Acetylcysteine / Q000627:therapeutic use; D000818:Animals; D000931:Antidotes; D003545:Cysteine / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D005978:Glutathione / Q000627:therapeutic use; D006846:Hydrocarbons, Halogenated / Q000506:poisoning*; D051381:Rats; D013997:Time Factors
D000931:Antidotes; D006846:Hydrocarbons, Halogenated; D005978:Glutathione; D003545:Cysteine; D000111:Acetylcysteine
Aktivnost' tsisteina pri intoksikatsii zhivotnykh razlichnymi galoiduglevodorodami alifaticheskogo riada.