Renal function in idiopathic respiratory distress syndrome.
Renal function was studied in 11 pre-term infants with idiopathic respiratory distress syndrome (IRDS) grade 1 according to Prod'hom's criteria. As a reference 16 healthy pre-term infants were studied. The groups did not differ with regard to mean gestational age (GA) and mean postnatal age (PNA). The studies were prefomred twice, first at a PNA of 33--37 hours and then at 132--148 hours. GFR and CPAH were determined with the single injection technique and the ability to excrete Na+ was determined following an oral Na+ load. GFR was higher in IRDS infants at the first investigation and slightly lower in IRDS infants at the second investigation. The GFR correlated to the lowest recorded PaO2 (r=0.45) in IRDS infants. CPAH was similar in IRDS and controls at the first, and lower in IRDS infants at the second investigation. The urinary Na+ excretion was significantly higher in IRDS infants. Treatment with digitalis was in part responsible for the high urinary Na+ excretion. The IRDS infants had a higher Na+ and glucose intake than the control infants. It is suggested that this higher intake is in part responsible for the relatively high GFR and urinary Na+ excretion in IRDS infants.
D001794:Blood Pressure; D005260:Female; D005947:Glucose / Q000008:administration & dosage; D006801:Humans; D007231:Infant, Newborn; D007444:Inulin; D007668:Kidney / Q000503:physiopathology*; D007677:Kidney Function Tests; D008297:Male; D009318:Natriuresis; D010313:Partial Pressure; D012127:Respiratory Distress Syndrome, Newborn / Q000503:physiopathology* / Q000628:therapy; D012964:Sodium / Q000008:administration & dosage / Q000652:urine; D010130:p-Aminohippuric Acid
D007444:Inulin; D012964:Sodium; D005947:Glucose; D010130:p-Aminohippuric Acid