[Alkyl derivatives of imidazole dicarboxylic acid diamides as inhibitors of the mitochondrial respiratory chain].
The effect of alkyl derivatives of imidasol-dicarboxylic acids diamides was investigated in vitro on the liver mitochondria of rats with tese derivatives being added into a cuvette for measuring in millimolar concentrations their action on the function of mitochondria, viz- the electron transport in the respiratory chain and oxidative phosphorylation. The study substances were found to inhibit the chain of the electrons transport to the mitochondria on the level of the NADN-dehydrogenase. The inhibitory activity rises in the series: norantipheine, antipheine, allylnorantipheine, propylnorantipheine, ethephil and ethimizol. Besides, ethephil is an inhibitor that blocks the transport of electrons between cytochromes "b" and "c".
D000818:Animals; D003864:Depression, Chemical; D003998:Dicarboxylic Acids / Q000494:pharmacology; D004579:Electron Transport / Q000187:drug effects*; D004789:Enzyme Activation / Q000187:drug effects; D007093:Imidazoles / Q000494:pharmacology*; D066298:In Vitro Techniques; D008930:Mitochondria, Liver / Q000187:drug effects*; D009247:NADH, NADPH Oxidoreductases / Q000037:antagonists & inhibitors; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D051381:Rats
D003998:Dicarboxylic Acids; D007093:Imidazoles; D009247:NADH, NADPH Oxidoreductases
Alkilproizvodnye diamidov imidazoldikarbonovykh kislot kak ingibitory mitokhondrial'noĭ dykhatel'noĭ tsepi.