Comparison of lactate pyruvate and potassium concentration in the cardiac lymph and, arterial and coronary sinus plasma in dogs.
Lactate (LA), pyruvate (PYR) and potassium (K) concentration in the cardiac lymph were compared with those in the arterial and coronary sinus plasma in dogs. In each substance, there was a good correlation between the plasma and cardiac lymph level in the control period. In respect to LA and PYR, the concentration in the cardiac lymph correlated more with that in the arterial plasma than in the coronary sinus one. During the infusion of isoproterenol, LA and PYR in the plasma increased, while K decreased. Each substance in the cardiac lymph changed to the same degree as in the plasma in mean values. Good correlation was also observed between the arterial plasma and cardiac lymph level during the administration of the agent. However, there was no correlation of PYR between the coronary sinus plasma and the cardiac lymph. During the administration of dipyridamole LA in the coronary sinus plasma increased and that in the arterial plasma decreased. LA in the cardiac lymph did decrease as in the arterial plasma. It is concluded that the concentrations of LA, PYR and K in the cardiac lymph can be changed depending upon changes in those in the plasma and the former two parameters seem to change depending upon those in the arterial plasma rather than the coronary sinus one.
D000818:Animals; D001158:Arteries; D003331:Coronary Vessels; D004176:Dipyridamole / Q000494:pharmacology; D004285:Dogs; D007545:Isoproterenol / Q000494:pharmacology; D007773:Lactates / Q000032:analysis* / Q000097:blood; D008196:Lymph / Q000032:analysis*; D011188:Potassium / Q000032:analysis* / Q000097:blood; D011773:Pyruvates / Q000032:analysis* / Q000097:blood; D014680:Veins
D007773:Lactates; D011773:Pyruvates; D004176:Dipyridamole; D007545:Isoproterenol; D011188:Potassium