Effect of inflammation on erythroid precursors (BFU-E and CFU-E) in bone marrow and spleen of mice.
Inflammation, induced in mice by a single intramuscular injection of turpentine, caused a long lasting reduction in the number of morphologically unrecognizable CFU-E in the bone marrow. This resulted in marked decreases in marrow erythroblasts and their iron incorporation into heme. The effect is attributed to blood-borne mediators of inflammation which either caused an emigration of progenitors of CFU-E from the marrow or inhibited their proliferation, possibly as the result of increases in marrow myelopoiesis. CFU-S as well as erythroid and myeloid precursors were markedly increased in the spleen during the inflammatory reaction.
D000818:Animals; D001853:Bone Marrow / Q000473:pathology* / Q000503:physiopathology; D002452:Cell Count; D004900:Erythroblasts / Q000473:pathology; D004912:Erythrocytes / Q000473:pathology*; D004920:Erythropoiesis; D004921:Erythropoietin / Q000494:pharmacology; D005260:Female; D006412:Hematopoietic Stem Cells / Q000473:pathology; D007249:Inflammation / Q000139:chemically induced / Q000473:pathology* / Q000503:physiopathology; D051379:Mice; D011086:Polycythemia / Q000473:pathology; D013154:Spleen / Q000473:pathology* / Q000503:physiopathology; D014425:Turpentine
D004921:Erythropoietin; D014425:Turpentine