[Effect of the cytotoxin of Central Asia cobra venom on the functional state of rat liver mitochondria].
A study was made of the action of various concentrations of cytotoxin (C), free of phospholipase A admixtures, on the respiration, oxidative phosphorylation of the rat liver mitochondria and their "ghosts", and also on the permeability of their internal membranes for various ions. Low C concentrations (10--25 micrometer) failed to influence the functional parameters of the intact mitochondria, but sharply increased the permeability of the internal membranes for monovalent ions. Apparently the uncoupling action of C on the mitochondrial "ghosts" was caused by the formation in the membrane of nonspecific conductivity "canals" with poor selectivity to the ion size and charge.
D000818:Animals; D003603:Cytotoxins / Q000494:pharmacology*; D004546:Elapid Venoms / Q000494:pharmacology*; D066298:In Vitro Techniques; D007477:Ions / Q000378:metabolism; D007811:Lanthanum / Q000494:pharmacology; D008274:Magnesium / Q000494:pharmacology; D008566:Membranes / Q000187:drug effects; D008930:Mitochondria, Liver / Q000187:drug effects*; D008933:Mitochondrial Swelling / Q000187:drug effects; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D010539:Permeability; D051381:Rats; D014475:Uncoupling Agents
D003603:Cytotoxins; D004546:Elapid Venoms; D007477:Ions; D014475:Uncoupling Agents; D007811:Lanthanum; D008274:Magnesium
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