title: 2:2 and 3:1 meiotic disjunctions in a carrier of a reciprocal 10/14 translocation.
abstract: The offspring of a female with a reciprocal whole-arm translocation between a chromosome No. 10 and a chromosome No. 14 is described. She gave birth to three cytogenetically different children: one with a normal, one with an abnormal but balanced, and one with an unbalanced karyotype. In these three cases, 2:2 disjunctions must have occurred during maternal meiosis. She also had a trisomy 14 abortion, which is assumed to have been caused by a 3:1 meiotic disjunction.
mesh_terms: D002901:Chromosomes, Human, 13-15; D002906:Chromosomes, Human, 6-12 and X; D005260:Female; D006801:Humans; D008540:Meiosis; D011247:Pregnancy; D014178:Translocation, Genetic; D014314:Trisomy