title: Immunopathology of the lens. II. 86Rb efflux and protein leakage from normal lenses exposed to antilens and antiuveoretina antibodies.
abstract: Normal rabbit lenses exposed in vitro to heterologous antilens and antiuveoretina antibodies lose control of the intracellular 86Rb and this effect is followed by a late leakage of lenticular proteins; both phenomena take place only in the presence of complement. This antibody-induced complement-dependent membrane damage might be involved in the pathogenesis of complicated cataracts in uveitis and in the self-maintenance of recurrent uveal inflammations.
mesh_terms: D000818:Animals; D001323:Autoantibodies; D002463:Cell Membrane Permeability; D003165:Complement System Proteins; D005136:Eye Proteins / Q000378:metabolism*; D007106:Immune Sera; D007908:Lens, Crystalline / Q000276:immunology* / Q000378:metabolism; D011817:Rabbits; D011868:Radioisotopes; D012160:Retina / Q000276:immunology; D012413:Rubidium; D014602:Uvea / Q000276:immunology
chemical_list: D001323:Autoantibodies; D005136:Eye Proteins; D007106:Immune Sera; D011868:Radioisotopes; D003165:Complement System Proteins; D012413:Rubidium