Pyrrole, furan, and thiophene oxamates as potential antiallergy agents.
Nine heterocyclic oxamic acid derivatives were synthesized and tested in the rat passive cutaneous anaphylactic assay as potential antiallergy agents. Some compounds also were tested for their effects on cholesterol-lipoprotein levels and for diuretic, antidiabetic, and antifertility activities in rats.
D000596:Amino Acids / Q000138:chemical synthesis*; D000818:Animals; D005663:Furans / Q000138:chemical synthesis / Q000494:pharmacology; D010072:Oxamic Acid / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects*; D011758:Pyrroles / Q000138:chemical synthesis / Q000494:pharmacology; D051381:Rats; D013876:Thiophenes / Q000138:chemical synthesis / Q000494:pharmacology
D000596:Amino Acids; D005663:Furans; D011758:Pyrroles; D013876:Thiophenes; D010072:Oxamic Acid