[The potentiation of betazol stimulated gastric acidity by prednisolone in dogs (author's transl)].
In a total of 46 dogs divided into 5 groups the acute effect of a high dose of prednisolone (40 mg/kg i.v.) on betazol stimulated gastric seccretion (5mg/kh s.c.) was investigated. There was no effect of prednisolone alone. The combination of betazol and prednisolone showed a significant potentiation of betazol stimulation. This effect was not seen after truncal vagotomy before stimulation. The mechanism is either cholinergic or an interaction in the metabolism of histamine.
D000818:Animals; D001625:Betazole / Q000494:pharmacology*; D001786:Blood Glucose; D004285:Dogs; D004357:Drug Synergism; D005750:Gastric Juice / Q000032:analysis / Q000378:metabolism*; D008297:Male; D011188:Potassium / Q000032:analysis; D011239:Prednisolone / Q000494:pharmacology*; D011720:Pyrazoles / Q000494:pharmacology*; D012964:Sodium / Q000032:analysis; D014628:Vagotomy
D001786:Blood Glucose; D011720:Pyrazoles; D001625:Betazole; D012964:Sodium; D011239:Prednisolone; D011188:Potassium
Die Potenzierung der Betazol-stimulierten Magensaftsekretion durch Prednisolon beim Huud.