[Effect of aggregation inhibitors on thrombocyte enzymatic activity].
Experiments on rabbits proved that amidopyrin, sulphatizonicotinoilamine-guanidine, chlorpromazine, triphthazine, euphylline and tedamine inhibit aggregation of thrombocytes and unidirectionally have an effect on the carbohydrate metabolism enzymes in these cells, both in vitro and in vivo following their single and coursewise introduction. They also activate the lactate- and glyceraldehide-3-phosphate-dehydrogenase and reduce the activity of glucose-6-phosphate-dehydrogenase.
D000628:Aminophylline / Q000494:pharmacology; D000632:Aminopyrine / Q000494:pharmacology; D000818:Animals; D001792:Blood Platelets / Q000187:drug effects / Q000201:enzymology*; D050260:Carbohydrate Metabolism; D002746:Chlorpromazine / Q000494:pharmacology; D004789:Enzyme Activation / Q000187:drug effects; D006146:Guanidines / Q000494:pharmacology; D066298:In Vitro Techniques; D010974:Platelet Aggregation / Q000187:drug effects*; D011817:Rabbits; D014268:Trifluoperazine / Q000494:pharmacology
D006146:Guanidines; D000632:Aminopyrine; D014268:Trifluoperazine; D000628:Aminophylline; D002746:Chlorpromazine
Vliianie nekotorykh ingibitorov agregatsii na aktivnost' trombotsitarnykh fermentov.