Inhibition of glycolysis by L-sorbose in dog erythrocytes.
We have demonstrated previously that in vitro L-sorbose acts directly on dog erythrocytes to induce hemolysis. Here we report that L-sorbose depresses lactate formation in dog hemolysates from glucose, mannose and fructose but not from glucose-6-phosphate and galactose, suggesting that L-sorbose interacts with glycolysis at the level of the hexokinase.
D000818:Animals; D001786:Blood Glucose; D004285:Dogs; D004912:Erythrocytes / Q000378:metabolism; D005632:Fructose / Q000097:blood; D005693:Galactosemias; D005958:Glucosephosphates / Q000097:blood; D006019:Glycolysis / Q000187:drug effects*; D006461:Hemolysis; D066298:In Vitro Techniques; D008358:Mannose / Q000097:blood; D013013:Sorbose / Q000494:pharmacology*
D001786:Blood Glucose; D005958:Glucosephosphates; D005632:Fructose; D013013:Sorbose; D008358:Mannose