title: Coronary blood flow in physically trained rats.
abstract: Coronary blood flow was measured using labelled microspheres (15 micrometer diameter) in sedentary and endurance trained rats during hypoxaemic conditions designed to develop coronary dilatation (Pa,O2 6.0 to 6.7 kPa [45 to 60 mmHg]). Rats that were trained for 12 to 18 weeks (26.8 m per minute, 15% gradient, 1 hour per day) had a significantly greater coronary blood flow conductance (15.3 +/- 1.0 mm3.min-1.kPa-1 aortic diastolic pressure, n = 20) than sedentary animals (10.8 +/- 0.9, n = 19). Even though cardiac hypertrophy (17%) was found in the trained animals, this increase in perfused mass accounted for only one-third of the increase in total coronary blood flow. Thus, there was a greater coronary blood flow per unit mass of the myocardium in the trained rats.
mesh_terms: D000818:Animals; D001835:Body Weight; D003326:Coronary Circulation; D006321:Heart / Q000033:anatomy & histology / Q000502:physiology; D006439:Hemodynamics / Q000187:drug effects; D000860:Hypoxia / Q000503:physiopathology; D008297:Male; D008729:Methoxamine / Q000494:pharmacology; D009929:Organ Size; D010806:Physical Education and Training; D010807:Physical Endurance; D051381:Rats
chemical_list: D008729:Methoxamine