Studies on the role of histamine and 5-hydroxytryptamine in immunity against the nematode Trichostrongylus colubriformis. V. Changes in amine levels in the intestine following infection of guinea pigs of different immune status.
A temporal relationship was established between the onset of expulsion of the parasitic nematode Trichostrongylus colubriformis from the intestine of both vaccinated and adoptively immunized guinea pigs with a sudden increase in small intestinal mucosal histamine to two or three times pre-infection levels. However, in guinea pigs whose capacity to expel T. colubriformis was inhibited by treatment with anti-lymphocyte serum, mucosal histamine remained at pre-infection levels. The results support previous findings which suggest an important role for histamine in the effector mechanism of the immune response of guinea pigs against T. colubriformis.
D000818:Animals; D000961:Antilymphocyte Serum / Q000494:pharmacology; D005260:Female; D006168:Guinea Pigs; D006632:Histamine / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000276:immunology* / Q000469:parasitology; D007421:Intestine, Small / Q000276:immunology; D007774:Lactation; D008297:Male; D011247:Pregnancy; D012701:Serotonin / Q000378:metabolism*; D013997:Time Factors; D014251:Trichostrongyloidea / Q000276:immunology; D014252:Trichostrongyloidiasis / Q000276:immunology*; D014611:Vaccination
D000961:Antilymphocyte Serum; D012701:Serotonin; D006632:Histamine