Solid-state dispersions employing urethan.
The dissolution rates of a number of drug-urethan solid-state dispersion systems were studied. A marked enhancement of the initial dissolution rates of several poorly water-soluble drugs was found when they were incorporated into a urethan matrix by heat fusion. These differences were considerable when pure substances such as griseofulvin, hydrocortisone, chloramphenicol, and acetaminophen were compared to the urethan-drug solid dispersion. Physical mixtures of the medicinal agents with urethan also gave a marked increase in the amount of drug in solution, with the value in most cases being over one-half that of the solid-state dispersion. Data are given, comparing ultrafiltration with samples filtered through cotton, regarding drug content remaining in solution.
D002701:Chloramphenicol / Q000032:analysis; D006118:Griseofulvin / Q000032:analysis; D006854:Hydrocortisone / Q000032:analysis; D012995:Solubility; D013535:Suspensions; D013997:Time Factors; D014520:Urethane / Q000032:analysis
D013535:Suspensions; D006118:Griseofulvin; D014520:Urethane; D002701:Chloramphenicol; D006854:Hydrocortisone