[Hypotension, mental disorders and changes in catecholamine excretion observed during the administration of disulfiram in a case of pheochromocytoma].
A case of pheocromocytoma treated with disulfiram during ten days in described. Hypotensive and psychiatric effects were observed, which disappeared upon discontinuation of the drug. Urinary amines decreased while the drug was used, and upon interruption of its administration dopamine increased, as a rebound phenomena probably due to availability of tissue dopamine previously blocked by DBH inhibition. The effect of simultaneous administration of alpha-methyldopa is considered.
D000310:Adrenal Gland Neoplasms / Q000188:drug therapy* / Q000503:physiopathology; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D002395:Catecholamines / Q000652:urine*; D004221:Disulfiram / Q000009:adverse effects* / Q000627:therapeutic use; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D010673:Pheochromocytoma / Q000188:drug therapy* / Q000503:physiopathology; D011605:Psychoses, Substance-Induced
D002395:Catecholamines; D004221:Disulfiram
Hipotensión, alteraciones psiquiátricas y cambios en la excreción de catecolaminas observados durante la administración de disulfiram en un caso de feocromocitoma.