Constant blood withdrawal method for area under plasma concentration-time curve.
The area under the plasma concentration-time curve (AUC) was measured after an intravenous injection of sodium salicylate and after intragastric administration of aspirin, using either an intermittent sampling and the trapezoid rule (AUC-trapezoid) or the recently introduced constant blood withdrawal method (AUC-integrated concentration). Six dogs were used in each study. The AUC-integrated concentration was significantly higher than the AUC-trapezoid. The difference between the two methods was more significant after the intravenous infusion than after the intragastric administration. The higher AUC-integrated concentration was attributed to the inclusion of the initial plasma levels, which is an inherent advantage of the constant blood withdrawal method.
D000818:Animals; D001241:Aspirin / Q000097:blood; D001800:Blood Specimen Collection / Q000379:methods*; D004285:Dogs; D005260:Female; D004364:Pharmaceutical Preparations / Q000097:blood*; D012980:Sodium Salicylate / Q000097:blood; D013997:Time Factors
D004364:Pharmaceutical Preparations; D001241:Aspirin; D012980:Sodium Salicylate