The covalent and tertiary structure of bovine liver rhodanese.
Bovine liver rhodanese is a single polypeptide of 293 amino acids in which the halves of the molecule assume analogous tertiary structures in the absence of substantial sequence homology. The sulphur atom transferred during catalysis is bound in persulphide linkage to Cys-247. Substrate binding seems to involve Arg-186 and Lys-249.
D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D002384:Catalysis; D002417:Cattle; D003545:Cysteine / Q000378:metabolism; D008099:Liver / Q000201:enzymology; D046911:Macromolecular Substances; D008958:Models, Molecular; D008970:Molecular Weight; D011487:Protein Conformation; D013466:Sulfurtransferases / Q000378:metabolism; D013884:Thiosulfate Sulfurtransferase / Q000378:metabolism; D014961:X-Ray Diffraction
D046911:Macromolecular Substances; D013466:Sulfurtransferases; D013884:Thiosulfate Sulfurtransferase; D003545:Cysteine