title: Steric requirements for the stimulation of glycosyltransferase activity by lysophosphatidylcholine.
abstract: 1-Palmitoyl-sn-glycerol-3-phosphocholine and 3-palmitoyl-sn-glycerol-1-phosphocholine have been found to be equipotent in the stimulation of membrane-bound glycosyltransferases in microsomes of rat intestinal villus cells. This indicates that the stimulatory effect of lysophosphatidylcholine is not stereospecific, but that it may be related to a specific detergent property dependent upon the peculiar balance of hydrophilic and hydrophobic components in the molecule.
mesh_terms: D000818:Animals; D005700:Galactosyltransferases / Q000378:metabolism; D006602:Hexosyltransferases / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000201:enzymology*; D008244:Lysophosphatidylcholines / Q000494:pharmacology*; D008861:Microsomes / Q000201:enzymology; D051381:Rats; D012799:Sialyltransferases / Q000378:metabolism; D013237:Stereoisomerism
chemical_list: D008244:Lysophosphatidylcholines; D005700:Galactosyltransferases; D006602:Hexosyltransferases; D012799:Sialyltransferases