Electrogenic hyperpolarization in canine cardiac Purkinje fibres exposed to calcium ionophores.
The Ca ionophores markedly enhance the increase of intracellular Ca occurring during Na-free perfusion and the hyperpolarization observed upon Na readmission may be due to rapid restoration of intracellular Na and resultant stimulation of both electrogenic sodium and calcium efflux.
D000200:Action Potentials / Q000187:drug effects*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism; D004285:Dogs; D006329:Heart Conduction System / Q000187:drug effects*; D007832:Lasalocid / Q000494:pharmacology*; D011690:Purkinje Fibers / Q000187:drug effects* / Q000378:metabolism; D012964:Sodium / Q000378:metabolism
D000900:Anti-Bacterial Agents; D012964:Sodium; D002118:Calcium; D007832:Lasalocid