Pseudoxanthoma elasticum.
Pseudoxanthoma elasticum (PXE) is a genetic disorder of connective tissue with multi-systemic manifestations. Although the skin changes are striking, the eye and cardiovascular lesions can be most devastating to the patient. A review of the clinical and pathologic findings and recent therapeutic approaches is presented. Recent investigations on the pathogenesis and genetics of PXE are also discussed.
D002318:Cardiovascular Diseases / Q000209:etiology; D005123:Eye / Q000473:pathology; D006801:Humans; D011561:Pseudoxanthoma Elasticum / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D012867:Skin / Q000473:pathology