[Possible role of genetic factors in increasing the serum neurotropic activity of schizophrenic patients].
The authors studied the accumulation of individuals with an increased neurotropic blood serum activity among the relatives of schizophrenic patients. In order to evaluate the degree and character of the genetical determination of the biological indices 2 independent approaches were used: the method of a sequential search of genetical significant threshold values of signs (within the framework of a poligenic Falkoner-Edwards model) and the method of a partition of the total phenotypic variance into main compounds on the basis of intrafamilial correlations. It was demonstrated that the studied signs are characterized by a very high degree of a genetical determination. It is assumed that the small amount of specific loci (major genes) with the effect of intraloci dominance or intraloci epistatic interaction are responsible for the given biological marker.
D005796:Genes; D006801:Humans; D007106:Immune Sera / Q000494:pharmacology*; D009474:Neurons; D010641:Phenotype; D012559:Schizophrenia / Q000097:blood / Q000235:genetics*
D007106:Immune Sera
O vozmozhnoĭ roli geneticheskikh faktorov v povyshenii neĭrotropnoĭ aktivnosti syvorotki krovi bol'nykh shizofrenieĭ.