Correlation between serum concentration and pharmacological effect on atrioventricular conduction time of the antiarrhythmic drug propafenone.
Seven patients with cardiac dysrhythmias received a single, oral, therapeutically effective dose of the antiarrhythmic drug propafenone. The serum levels correlated well with changes in atrioventricular conduction times during the postabsorptive elimination phase (r = 0.8610, p less than 0.001). The mean half-lives of the serum level and the electrocardiographic effect (PQ-time) were 3.6 +/- .2 h and 3.8 +/- 0.6 h, respectively.
D000328:Adult; D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000097:blood / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D004562:Electrocardiography; D006207:Half-Life; D006329:Heart Conduction System / Q000187:drug effects*; D006801:Humans; D008875:Middle Aged; D011427:Propiophenones / Q000097:blood / Q000494:pharmacology*; D013997:Time Factors
D000889:Anti-Arrhythmia Agents; D011427:Propiophenones