Differential effects of sodium meglumine calcium metrizoate on the inotropic state of normal and ischemic myocardium.
Sodium meglumine calcium metrizoate was injected into isolated blood-perfused canine hearts to evaluate the effect of contrast agents containing calcium on normal and ischemic myocardium. Under normal perfusion pressure and mild ischemia, this contrast agent produced a positive inotropic effect, but during profound ischemia, this positive effect was followed by a period of myocardial depression. These findings indicate that the addition of an inotropic agent to contrast medium can produce a paradoxical depressant effect which can be deleterious to the ischemic myocardium.
D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D003327:Coronary Disease / Q000503:physiopathology*; D004285:Dogs; D066298:In Vitro Techniques; D007463:Iodobenzoates / Q000494:pharmacology*; D008536:Meglumine / Q000494:pharmacology; D008794:Metrizoic Acid / Q000031:analogs & derivatives / Q000494:pharmacology*; D009200:Myocardial Contraction / Q000187:drug effects*; D013268:Stimulation, Chemical
D007463:Iodobenzoates; D008536:Meglumine; D008794:Metrizoic Acid; C021342:methylglucamine metrizoate; D002118:Calcium