title: [Changes in RNA biosynthesis and ultrastructure of hepatic cells as affected by sodium ribonucleate].
abstract: Sodium ribonucleate (per os application) increased the biosynthesis of mitochondrial, nuclear and cytoplasmic RNA in the rat liver and transportation of nuclear RNA into the cytoplasm. Administration of ribonucleate changed the ultrastructure of hepatocytes, increased nuclear and nucleolar diameter, the number of rough endoplasmic elements, reticulum and glycogen particles and decreased the size of the mitochondria. This suggests that sodium ribonucleate can stimulate the biosynthesis of RNA and change the ultrastructure of hepatocytes also with application per os.
mesh_terms: D000818:Animals; D002466:Cell Nucleolus / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D002467:Cell Nucleus / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D003593:Cytoplasm / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D012313:RNA / Q000096:biosynthesis* / Q000494:pharmacology*; D051381:Rats
chemical_list: D012313:RNA
vernacular_title: Iemenenie biosinteza RNK i ul'trastruktury kletok pechenipod vliianiem ribonukleinata natriia.