title: [Biochemical study of the glycosaminoglycan peptides obtained from osteoarthrotic and normal femoral heads (author's transl)].
abstract: Glycosaminoglycan peptides prepared by papain hydrolysis of different regions were obtained from osteoarthrotic and normal human femoral heads. Data obtained in these experiments show that in osteoarthrosis a decrease in keratan sulfate and an increase in chondroitin sulfate are observed. Since keratan sulfate appeared to play an important role in proteoglycan aggregation, we suggest that the keratan sulfate decrease is one of the factors involved in the cartilage disorder observed in patients suffering from osteoarthrosis.
mesh_terms: D000368:Aged; D001847:Bone Diseases / Q000378:metabolism*; D002358:Cartilage, Articular / Q000032:analysis*; D055598:Chemical Phenomena; D002621:Chemistry; D002809:Chondroitin Sulfates / Q000032:analysis; D004587:Electrophoresis, Agar Gel; D005269:Femur / Q000032:analysis; D006025:Glycosaminoglycans / Q000032:analysis*; D006801:Humans; D007592:Joint Diseases / Q000378:metabolism*; D007632:Keratan Sulfate / Q000032:analysis; D008875:Middle Aged; D010455:Peptides / Q000032:analysis*; D011509:Proteoglycans / Q000032:analysis
chemical_list: D006025:Glycosaminoglycans; D010455:Peptides; D011509:Proteoglycans; D002809:Chondroitin Sulfates; D007632:Keratan Sulfate
vernacular_title: Etude biochimique comparative des glycosaminoglycannes peptides du cartilage articulaire de la tête fémorale humaine normale et arthrosique.