Correlation of quinidine absorption with disintegration and dissolution rates.
The dissolution profiles of four commercial quinidine sulfate tablets were determined using the USP rotating-basked dissolution apparatus. Substantial differences in dissolution half-times were noted and compared to previously reported disintegration times, absorption rate constants, and times of appearance of peak serum concentrations. Rank-order correlations were observed among all combinations of in vivo and in vitro parameters, indicating that the absorption rates of these tablets are controlled by both disintegration and dissolution.
D002626:Chemistry, Pharmaceutical; D007408:Intestinal Absorption; D011802:Quinidine / Q000378:metabolism*; D012995:Solubility; D013997:Time Factors
D011802:Quinidine