The effect of O-(beta-hydroxyethyl)-rutoside (HR) on macromolecular leakage, thrombosis and haemostasis in experimental animals.
O-(beta-hydroxyethyl)-rutoside (HR) (Venoruton, Zyma AS, Nyon, Switzerland) has been investigated experimentally to evaluate the effect on microvascular permeability and thromboembolism. Permeability to macromolecules is diminished in a hamster cheek-pouch model. Haemostatic plug formation is impaired whereas laser-induced intravascular platelet aggregation is uninfluenced. There is a small but insignificant protection against sodium morrhuate (Eli Lilly and Co., Indianapolis, Indiana) induced femoral vein thrombosis.
D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects*; D006224:Cricetinae; D006487:Hemostasis / Q000187:drug effects*; D006896:Hydroxyethylrutoside / Q000097:blood / Q000494:pharmacology* / Q000627:therapeutic use; D046911:Macromolecular Substances; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D012431:Rutin / Q000031:analogs & derivatives*; D012976:Sodium Morrhuate; D013924:Thrombophlebitis / Q000139:chemically induced / Q000517:prevention & control*
D006896:Hydroxyethylrutoside; D046911:Macromolecular Substances; D012431:Rutin; D012976:Sodium Morrhuate