title: Cows' milk-sensitive enteropathy.
abstract: Serial small intestinal biopsies related to withdrawal and challenge with cows' milk are described in 5 infants with cows' milk protein intolerenace. On the basis of these serial observations the existence of a cows' milk-sensitive enteropathy in infancy is clearly established. The cows' milk-sensitive mucosal lesion varied in its severity ranging from a partly flat mucosa to a mild degree of partial villous atrophy. Intraepithelial lymphocyte counts rose after a positive milk challenge, but on only one occasion to a level outside the normal range. The technique of serial biopsies related to dietary milk enables a firm diagnosis of cows' milk intolerance to be made upon the basis of a single milk challenge. Clinically this appears to be a temporary condition which disappears by the age of 2 years.
mesh_terms: D000818:Animals; D001706:Biopsy; D002417:Cattle; D003968:Diarrhea, Infantile / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D004186:Disaccharidases / Q000378:metabolism; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007413:Intestinal Mucosa / Q000473:pathology; D007958:Leukocyte Count; D008214:Lymphocytes / Q000473:pathology; D008286:Malabsorption Syndromes / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D008297:Male; D008894:Milk Proteins / Q000009:adverse effects*
chemical_list: D008894:Milk Proteins; D004186:Disaccharidases