The release of gentamicin from polymethylmethacrylate beads. An experimental and pharmacokinetic study.
Gentamicin incorporated in beads of polymethylmethacrylate has been shown capable of being released over a period of several months in concentrations sufficiently high to control most pathogens. The therapeutic efficacy of such beads has been demonstrated in a model of osteomyelitis of the femur in the dog. Good tolerance has been shown, both in the animal model and in tissue cultures. In forty-one patients with infection of either bone or soft tissue, mainly of the lower limb, the findings were similar. The concentrations in serum and urine were low, which excludes side-effects. The insertion of gentamicin-PMMA beads may prove to be a valuable new form of local antibiotic therapy.
D000818:Animals; D003692:Delayed-Action Preparations; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D005839:Gentamicins / Q000008:administration & dosage* / Q000627:therapeutic use / Q000633:toxicity; D008768:Methylmethacrylates; D010019:Osteomyelitis / Q000188:drug therapy*; D013997:Time Factors
D003692:Delayed-Action Preparations; D005839:Gentamicins; D008768:Methylmethacrylates