Hormone-sensitive adenylate cyclase in human colonic mucosa.
Human colonic adenylate cyclase has been shown to be sensitive to vasoactive intestinal polypeptide (VIP) and prostaglandins of the E- and F-type. Maximal activation of enzyme activity averaged 200% for VIP and 300-350% for the E-prostaglandins. Both classes of hormones had an additive effect on enzyme activity indicating the existence of two distinct hormone-sensitive adenylate cyclases in human colonic mucosa.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D003106:Colon / Q000201:enzymology*; D004789:Enzyme Activation; D006801:Humans; D007413:Intestinal Mucosa / Q000201:enzymology*; D011454:Prostaglandins A / Q000494:pharmacology; D011458:Prostaglandins E / Q000494:pharmacology; D011460:Prostaglandins F / Q000494:pharmacology; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology
D011454:Prostaglandins A; D011458:Prostaglandins E; D011460:Prostaglandins F; D014660:Vasoactive Intestinal Peptide; D000262:Adenylyl Cyclases