Histocompatibility (HLA) factors in ataxia telangiectasia.
In the recent studies conducted in patients with various types of primary immunodeficiency diseases, an increased frequency of HLA-A1 or HLA-A2 antigens was reported. In order to determine the frequency of the histocompatibility antigens in ataxia telangiectasia (A-T), HLA typing was carried out in 30 patients with A-T along with their 23 parents and 4 siblings. The results were compared with 138 healthy controls. That study showed no significant difference for the frequencies of 19 HLA antigens of the A and B loci between the controls and A-T patients or their parents-siblings.
D000293:Adolescent; D001260:Ataxia Telangiectasia / Q000235:genetics* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D006680:HLA Antigens / Q000032:analysis; D006801:Humans
D006680:HLA Antigens