Prostaglandins released into human burn blister fluid.
Acidic lipids were isolated from human burn blister fluid and the presence of prostaglandins E and F compounds was demonstrated by the thin-layer chromatography. Prostaglandins E1, E2 and F2alpha were identified and quantitatively determined by radioimmunoassay and by gas-liquid chromatography/mass spectrometry. Analyses on burn blister fluid obtained from 35 patients with skin burn indicated an extensive release of prostaglandins into the blister after burn injury in a few hours. The high levels of prostaglandins in burn blister fluid decreased gradually during 24 hours after burn.
D000293:Adolescent; D000328:Adult; D001768:Blister / Q000378:metabolism*; D002056:Burns / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D005122:Exudates and Transudates / Q000032:analysis; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011458:Prostaglandins E / Q000096:biosynthesis / Q000378:metabolism*; D011460:Prostaglandins F / Q000096:biosynthesis / Q000378:metabolism*
D011458:Prostaglandins E; D011460:Prostaglandins F