[Experimental study of the organotropic properties of dactinomycin].
Dactinomycin was studied pharmacologically on experimental animals. When dactinomycin was administered to the test-animals in doses close to the therapeutic ones for humans, suppression of the bone marrow blood formation was registered in spite of some increase in the number of the reticulocytes and thrombocytes in the peripheral blood and acceleration of the process of blood coagulation. In addition, the urea nitrogen blood levels increased. When the drug was administered in higher doses, suppression of the bone marrow blood formation was pronounced and the number of the leucocytes, reticulocytes and thrombocytes in the peripheral blood decreased. The rate of the blood coagulation decreased, while the biochemical values of the blood were indicative of impairement of the liver and kidney functions.
D000818:Animals; D001773:Blood Cells / Q000187:drug effects; D001777:Blood Coagulation / Q000187:drug effects; D001853:Bone Marrow / Q000187:drug effects; D003609:Dactinomycin / Q000494:pharmacology / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D007928:Lethal Dose 50; D051379:Mice; D011817:Rabbits; D051381:Rats; D013997:Time Factors
D003609:Dactinomycin
Eksperimental'noe izuchenie organotropnykh svoĭstv daktinomitsina.