[Effect of sulfonylurea preparations on the course of pregnancy and the state of the fetuses of female rats with alloxan prediabetes, latent diabetes and mild forms of manifest diabetes].
The influence of antidiabetic sulphanylamides, used before the occurrence of pregnancy, on the weight of fetuses and placentae was revealed in rats with alloxan "prediabetes", latent diabetes, and manifest diabetes. Diabetes compensation before the occurrence of pregnancy in rats with "prediabetes" and latent diabetes by means of chlorpropamide, and in rats with manifest diabetes with chlorpropamide together with biguanides led to a significant reduction of the weight of fetuses and prevented their death.
D000818:Animals; D001645:Biguanides / Q000627:therapeutic use; D001835:Body Weight / Q000187:drug effects; D002747:Chlorpropamide / Q000627:therapeutic use; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D005260:Female; D005333:Fetus / Q000187:drug effects*; D007004:Hypoglycemic Agents; D010920:Placenta / Q000187:drug effects; D011236:Prediabetic State / Q000188:drug therapy*; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000188:drug therapy*; D051381:Rats; D013453:Sulfonylurea Compounds / Q000627:therapeutic use*; D013997:Time Factors
D001645:Biguanides; D007004:Hypoglycemic Agents; D013453:Sulfonylurea Compounds; D002747:Chlorpropamide
Vliianie preparatov sul'fanilmocheviny na techenie beremennosti i sostoianie plodov krys-samok s alloksanovym "prediabetom", skrytym diabetom i legkimi formami iavnogo diabeta.