title: [Asymptomatic chronic-persisting hepatitis B in a young child as source of infection of hepatitis B within a family (author's transl)].
abstract: Five members of an eight-member family fell ill with an acute icteric hepatitis B of the same subtype within eleven months. In all probability the source of the infection was a just over one-year-old fostered child with asymptomatic chronic persisting hepatitis B and signs of massive viraemia (usually high HBs antigen concentration, high virus-specific DNA-polymerase activity and positive HBe antigen test). No relation could be demonstrated between HLA constellation and illness in the family members. Since no specific treatment is available, the only possible prophylactic measure is to isolate the child in the present environment, to avoid further cases of the disease.
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D002353:Carrier State; D002675:Child, Preschool; D002908:Chronic Disease; D004196:Disease Outbreaks; D005260:Female; D006680:HLA Antigens / Q000032:analysis; D006509:Hepatitis B / Q000175:diagnosis*; D006510:Hepatitis B Antibodies / Q000032:analysis; D006511:Hepatitis B Antigens / Q000032:analysis; D006801:Humans; D008297:Male
chemical_list: D006680:HLA Antigens; D006510:Hepatitis B Antibodies; D006511:Hepatitis B Antigens
vernacular_title: Kleinkind mit asymptomatischer chronisch-persistierender Hepatitis B als Infektionsquelle für intrafamiliären Hepatitis-B-Ausbruch.