[Effect of insulin on oxidative phosphorylation in the liver and heart mitochondria of adrenalectomized rats].
The effect of insulin was studied as applied to the inhibited under conditions of adrenalectomy process of oxidative phosphorylation in the rat liver and heart mitochondria. It is established that adrenalectomy does not change oxidative activity of mitochondria but inhibits the process of phosphorylation, which results in the decreased values of the ADP/O coefficient and the respiratory control. Insulin administered to the adrenalectomized rats 3h before the experiments reduces the disturbed oxidative phosphorylation in mitochondria of the liver and heart by intensifying the degree of ADP phosphorylation.
D000244:Adenosine Diphosphate / Q000378:metabolism; D000315:Adrenalectomy; D000818:Animals; D007328:Insulin / Q000494:pharmacology*; D008929:Mitochondria, Heart / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000378:metabolism*; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D051381:Rats
D007328:Insulin; D000244:Adenosine Diphosphate
Vliianie ubsykuba ba ijuskutek'noe fosforilirovanie v mitokhondriiiakh pecheni i serdtsa adrenalektomirovannykh krys.