[Effect of thyroxine on radioactive iodine accumulation in the thyroid glands of hemithyroidectomized rats of different ages].
Experiments were carried out on hemithyroidectomized male rats aged from 2 to 20 months. Thyroxin administration in a dose of 1 microgram per 100 g of body weight on the 5th day of the experiment led to significantly greater suppression of radioiodine accumulation in the lobe of the thyroid gland remaining after the operation in 16--20-month-old rats in comparison with 2--2 1/2-month-old animals. The data obtained confirmed a conclusion drawn earlier on the reduction with ageing of the hypothalamo-hypophysial threshold to the homeostatic thyroxin inhibition.
D000042:Absorption; D000367:Age Factors; D000818:Animals; D007455:Iodine / Q000378:metabolism*; D007457:Iodine Radioisotopes; D008297:Male; D051381:Rats; D013961:Thyroid Gland / Q000187:drug effects* / Q000378:metabolism; D013965:Thyroidectomy; D013974:Thyroxine / Q000494:pharmacology*
D007457:Iodine Radioisotopes; D007455:Iodine; D013974:Thyroxine
Vliianie tiroksina na nakoplenie radioaktivnogo ĭoda v shchitovidnykh zhelezakh gemitireoidéktomirovannykh krys razlichnogo vozrasta.