Increased effect of apomorphine on homovanillic acid in rats terminated from chronic haloperidol.
Rats who were administered apomorphine seven days after termination of chronic treatment with haloperidol had significantly (59%) lower level of brain HVA than saline control rats. This finding is consistent with the behavioral evidence suggesting supersensitivity of post-synaptic dopamine receptors after termination of chronic haloperidol.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D006220:Haloperidol / Q000494:pharmacology*; D006719:Homovanillic Acid / Q000378:metabolism*; D010648:Phenylacetates / Q000378:metabolism*; D051381:Rats
D010648:Phenylacetates; D006220:Haloperidol; D001058:Apomorphine; D006719:Homovanillic Acid