Dependence of cell-mediated immune lysis of the EL-4 ascitic lymphoma on its population composition and rhythm.
Investigations on cell-mediated immune release of 51Cr from the EL-4 ascitic lymphoma showed that daily rhythmic changes can be correlated with the dominance of certain cell types in the population. Cells in compartment 1--i.e., those representing true G0, early G1, S and M--are most sensitive to effector cell attack. During the establishment 96-hour appearance cycle of the population, each day a different compartment will predominate, with corresponding variations in percent immune release. On days when spontaneous 51Cr release shows a maximum, immune release is minimal. The differences between maximal values of immune release may reach more than 300%, when findings from different days in the appearance cycle are compared.
D000818:Animals; D002453:Cell Cycle; D002860:Chromium Radioisotopes; D003602:Cytotoxicity, Immunologic; D007399:Interphase; D008223:Lymphoma / Q000276:immunology / Q000473:pathology*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008938:Mitosis; D009374:Neoplasms, Experimental; D010507:Periodicity
D002860:Chromium Radioisotopes