title: Abnormal cisternogram associated with Diamox therapy.
abstract: A cisternogram characteristic of normal-pressure hydrocephalus was obtained from a patient on Diamox who was being evaluated for rapid mental deterioration. A repeat cisternogram after Diamox was discontinued was nearly normal. We hypothesize that the initial abnormality resulted from reduced cerebrospinal fluid production caused by carbonic anhydrase inhibition; this defect (reduced flow) led to a net reflux of tracer into the ventricles. The reflux is believed to be due to the reduction of bulk cerebrospinal fluid from the ventricles.
mesh_terms: D000086:Acetazolamide / Q000009:adverse effects* / Q000627:therapeutic use; D000368:Aged; D002946:Cisterna Magna; D003704:Dementia / Q000000981:diagnostic imaging*; D006801:Humans; D006849:Hydrocephalus / Q000188:drug therapy*; D006850:Hydrocephalus, Normal Pressure / Q000000981:diagnostic imaging / Q000188:drug therapy*; D007204:Indium / Q000008:administration & dosage; D008297:Male; D004369:Pentetic Acid / Q000008:administration & dosage / Q000627:therapeutic use; D011877:Radionuclide Imaging
chemical_list: D007204:Indium; D004369:Pentetic Acid; D000086:Acetazolamide