Deoxycorticosterone and 17-ketosteroids. Elevated levels in adult hypertensive patients.
Plasma 11-deoxycorticosterone levels were manyfold elevated in three adult patients with hypertension and elevated urinary excretion levels of 17-ketosteroids but without Cushing's syndrome. Dexamethasone therapy resulted in suppression of these steroids and in improvement of blood pressure in two of the patients. A partial adrenal 11beta-hydroxylase deficiency appears to best explain these findings.
D015068:17-Ketosteroids / Q000652:urine*; D000311:Adrenal Glands / Q000378:metabolism; D000328:Adult; D000367:Age Factors; D001794:Blood Pressure / Q000187:drug effects; D003480:Cushing Syndrome; D003900:Desoxycorticosterone / Q000097:blood*; D003907:Dexamethasone / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000188:drug therapy / Q000652:urine; D008297:Male; D006899:Mixed Function Oxygenases / Q000172:deficiency
D015068:17-Ketosteroids; D003900:Desoxycorticosterone; D003907:Dexamethasone; D006899:Mixed Function Oxygenases