Intermittent occlusion of the abdominal aorta: a conceptual approach in treating below-diaphragm tumors (a preliminary report).
A modified form of tumor strangulation as a possible treatment modality is considered. Intermittent intra-aortic occlusion by means of specially designed catheters and equipment is described. As a preliminary feasibility study, occlusion in non-tumor-bearing animals has begun, with projection for future human cases anticipated. Theoretical concepts of substances from the occlusion process resulting in cure and specific immunity in experimental animals are evaluated, and the belief in the development of modified antigens and antibodies as a consequence of restriction of a growing tumor's proliferating blood supply is discussed.
D000818:Animals; D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm; D001012:Aorta, Abdominal / Q000601:surgery*; D002408:Catheters, Indwelling; D003964:Diaphragm; D004285:Dogs; D007109:Immunity; D009374:Neoplasms, Experimental / Q000098:blood supply / Q000276:immunology / Q000628:therapy*; D010215:Papio; D012107:Research Design; D013997:Time Factors
D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm