title: [Autologous 131J-tagged human fibrinogen for early detection of venous thrombosis (preparation, biological and in vivo properties) (author's transl)].
abstract: A method for preparation of autologous 131J-tagged human fibrinogen is demonstrated. In vitro the preparation is characterized by content of fibrinogen, protein, plasminogen, clottability and molecular weight. Total plasma radioactivity, specific radioactivity, non-protein-bound radioactivity, biologic half-life and the local activity at the thrombus define the properties in vivo. With the above criteria autologous 131-J-tagged human fibrinogen was shown to be useful for early diagnosis of venous thrombosis.
mesh_terms: D001780:Blood Coagulation Tests / Q000379:methods; D005340:Fibrinogen / Q000032:analysis*; D006801:Humans; D007457:Iodine Radioisotopes; D013927:Thrombosis / Q000097:blood*; D013997:Time Factors
chemical_list: D007457:Iodine Radioisotopes; D005340:Fibrinogen
vernacular_title: Autologes 131J-Humanfibrinogen zur Thrombosefrühdiagnostik. (Herstellung, biochemische Eigenschaften und Verhalten in vivo).