[Antiarrhythmic effect of propafenone in relation to serum concentration and conduction time (author's transl)].
7 patients with stable cardiac dysrhythmias (ectopic beats of ventricular origin) received a single oral dose of 900 mg Propafenone. Besides the antiarrhythmic effect of propafenone the effect on changes of PQ- and QRS duration as well as the corresponding serum concentration was measured. A significant correlation between changes of PQ-time and serum concentration (r = 0.6810, p less than 0.001) was found. The half-life of serum level was 3.6 +/- 0.2 h, that of PQ-time prolongation 3.8 +/- 0.6 h. A complete suppression of all ectopic beats has been achieved in all treated patients for 6--8 hours.
D000328:Adult; D000368:Aged; D000889:Anti-Arrhythmia Agents; D001145:Arrhythmias, Cardiac / Q000188:drug therapy*; D004562:Electrocardiography; D005260:Female; D006329:Heart Conduction System / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D011427:Propiophenones / Q000097:blood / Q000494:pharmacology*
D000889:Anti-Arrhythmia Agents; D011427:Propiophenones
Antiarrhythmische Wirksamkeit von Propafenon in Abhängigkeit von Serumkonzentration und Erregungsleitungshemmung.