[Changes of alcohol resorption through apomorphine in subemetic dosage].
Apomorphine in sub-emetic doses inhibits gastric emptying without producing nausea or vomiting. This discovery was applied to 21 persons to find out correlation between gastric emptying rate and alcohol absorption. In the 60 minutes after a single oral ingestion the shape of the alcohol-tolerance curve is considerably flatter after administration of apromorphine as compared to controls. The peak blood alcohol concentration occurs later and is significantly lower. These findings suggest that absorption of ethyl alcohol after a single oral alcohol ingestion can be controlled to a considerable extent by the gastric emptying rate.
D000328:Adult; D000368:Aged; D001058:Apomorphine / Q000008:administration & dosage / Q000494:pharmacology*; D000431:Ethanol / Q000097:blood / Q000378:metabolism*; D005746:Gastric Emptying / Q000187:drug effects*; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects*; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D009325:Nausea / Q000517:prevention & control; D014839:Vomiting / Q000517:prevention & control
D000431:Ethanol; D001058:Apomorphine
Veränderung der Alkoholresorption durch Apomorphin in subemetischer Dosierung.