Tc-99m human serum albumin: a suitable agent for plasma volume measurements in man.
In 16 patients we have carried out simultaneous plasma-volume measurements with human serum albumins tagged with Tc-99m (Tc-99m HSA) and I-131 (I-131 HSA). The correlation coefficient was 0.987. Tc-99m HSA, prepared from kits that predictably yield high labeling efficiency (and thereby negligible amounts of TCO4-), is clearly a superior agent for repeat plasma volume determinations, because of its shorter half-life and the reduced radiation dose to the subject.
D006801:Humans; D008722:Methods; D010953:Plasma Volume; D011829:Radiation Dosage; D011933:Reagent Kits, Diagnostic; D012709:Serum Albumin; D012711:Serum Albumin, Radio-Iodinated; D013667:Technetium
D011933:Reagent Kits, Diagnostic; D012709:Serum Albumin; D012711:Serum Albumin, Radio-Iodinated; D013667:Technetium