Structure--activity relationships of anesthetic ethers using molecular connectivity.
The structure--activity relationships in the anesthetic and toxic actions of 28 aliphatic ethers were simple functions of molecular connectivity indexes. These quantitative relationships are discussed briefly in the light of theories of the mechanism of action of general anesthetics.
D000777:Anesthetics / Q000633:toxicity; D000818:Animals; D004987:Ethers / Q000494:pharmacology* / Q000633:toxicity; D007928:Lethal Dose 50; D051379:Mice; D013329:Structure-Activity Relationship
D000777:Anesthetics; D004987:Ethers