[Streptomycin-induced damage of the spiral ganglion].
The neuronal density in the spiral ganglion was investigated in normal and in streptomycin-intoxicated guinea pigs. Streptomycin was administered in a dose of 250 mg/kg for 21 days. 6 weeks after the streptomycin exposure a histological examination revealed a decrease in ganglion cell density in the spiral ganglion, with maximum loss in the apical portion of the ganglion. As mechanisms of the ototoxic effect, a secondary degeneration of spiral ganglion cells after hair cell loss or a primary neurotoxic degeneration are discussed.
D000818:Animals; D003056:Cochlear Nerve / Q000187:drug effects*; D005724:Ganglia / Q000187:drug effects*; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000187:drug effects / Q000473:pathology; D009410:Nerve Degeneration / Q000187:drug effects; D013307:Streptomycin / Q000008:administration & dosage / Q000633:toxicity*
D013307:Streptomycin
Zur Steptomycinschädigung des Ganglion spirale.