Steroid hydroxylase induction in cultured human lymphocytes: effects of the menstrual cycle.
Steroid hydroxylases (SAH) are inducible in cultured human lymphocytes following treatment with estradiol-17beta. The enzyme systems induced are carbon monoxide sensitive and convert estradiol-17beta to a metabolite chromatographically indistinguishable from estriol. The level of inducibility of SAH varies drastically over a normal menstrual cycle with maximum induction in the late follicular phase and minimum induction during the luteal phase. The use of an oral contraceptive containing both a synthetic progestogen and ethynyl estradiol reduced SAH induction levels to those typically seen during the luteal phase of the menstrual cycle.
D002478:Cells, Cultured; D003276:Contraceptives, Oral / Q000494:pharmacology; D003280:Contraceptives, Oral, Synthetic / Q000494:pharmacology; D004790:Enzyme Induction / Q000187:drug effects; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000201:enzymology*; D008598:Menstruation; D010060:Ovulation; D013250:Steroid Hydroxylases / Q000096:biosynthesis / Q000097:blood*
D003276:Contraceptives, Oral; D003280:Contraceptives, Oral, Synthetic; D004958:Estradiol; D013250:Steroid Hydroxylases