title: Synthesis and analgesic activity of some long-acting piperidinospiro derivatives of methadone.
abstract: A congener of methadone, in which the metabolically labile C-6 dimethylamino moiety was replaced with a piperidinospiro derivative, was reduced and acetylated. This conversion produced a marked increase in the duration of analgesia, a trend similar to that found for methadone.
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis*; D000818:Animals; D008297:Male; D008691:Methadone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D013997:Time Factors
chemical_list: D000700:Analgesics; D008691:Methadone