title: High-pressure liquid chromatographic analysis of melphalan in plasma.
abstract: A new sensitive and rapid high-pressure liquid chromatographic determination of melphalan in plasma was developed. Recovery of 1 microgram added to 1 ml of plasma at 23 degrees was 94% but was greatly reduced at higher temperature. The method has been applied to plasma determinations of melphalan in rats and humans and is currently being utilized for human pharmacokinetic studies.
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D006801:Humans; D008558:Melphalan / Q000097:blood*; D008722:Methods; D051381:Rats
chemical_list: D008558:Melphalan