Renin-aldosterone responsiveness in uncomplicated juvenile-type diabetes mellitus.
The changes in plasma renin activity (PRA) and plasma aldosterone concentration (PA) in response to dietary sodium restriction and upright posture were evaluated in 7 patients with juvenile-type, insulin-dependent, uncomplicated diabetes mellitus and in 5 healthy volunteers. All patients had normal blood pressure, 24-hour urine protein excretion and endogenous creatinine clearance. Renal sodium conservation and concentrating ability were grossly normal and 5 patients so tested, had normal renal acidification. PRA and PA were normal in every subject suggesting that abnormalities of the renin-aldosterone axis are late complications of diabetes mellitus usually associated with hypertension and nephropathy or neuropathy.
D000328:Adult; D000450:Aldosterone / Q000097:blood*; D001794:Blood Pressure; D002245:Carbon Dioxide / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D004039:Diet, Sodium-Restricted; D005260:Female; D006801:Humans; D008297:Male; D011187:Posture; D011188:Potassium / Q000097:blood; D012083:Renin / Q000097:blood*; D012964:Sodium / Q000097:blood
D002245:Carbon Dioxide; D000450:Aldosterone; D012964:Sodium; D012083:Renin; D011188:Potassium