The effect of calcitonin on secretin-stimulated pancreatic secretion in man.
The effect of calcitonin on pancreatic secretion was studied in man. After steady-state secretion had been achieved with a constant intravenous infusion of secretin (2 microgram/kg/h), either calcitonin (0,16 and 0,32 microgram/kg/h) or 0,15M NaCl was infused over a period of 80 minutes. Calcitonin did not affect pancreatic volume output or bicarbonate concentration, but amylase concentration and output were significantly inhibited (P less than 0.025). The colour index in the duodenal juice was unchanged by calcitonin. No changes were observed in blood glucose or serum calcium concentrations.
D000328:Adult; D000681:Amylases / Q000032:analysis; D001639:Bicarbonates / Q000032:analysis; D002116:Calcitonin / Q000494:pharmacology*; D003864:Depression, Chemical; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010189:Pancreatic Juice / Q000032:analysis / Q000201:enzymology / Q000378:metabolism*; D012633:Secretin / Q000494:pharmacology*; D012636:Secretory Rate / Q000187:drug effects
D001639:Bicarbonates; D012633:Secretin; D002116:Calcitonin; D000681:Amylases