title: Renal function during neurolept anaesthesia.
abstract: Renal function and central haemodynamics were studied in eight patients, without known histories of renal or cardiovascular disease, during and immediately after upper abdominal surgery under neurolept anaesthesia. Inulin and PAH clearance, fractional sodium and fractional osmolar excretion decreased, while fractional free water reabsorption increased under anaesthesia. Cardiac output, mean systemic arterial pressure and systemic vascular resistance remained virtually unchanged both per- and postoperatively. Renal haemodynamics were promptly restored postoperatively, while fractional sodium and fractional osmolal excretion were unaltered and antidiuresis increased. It is concluded that neurolept anaesthesia, as far as renal function is concerned, is well suited for the anaesthetic management of the poor-risk patient.
mesh_terms: D000005:Abdomen / Q000601:surgery; D000328:Adult; D001794:Blood Pressure; D002302:Cardiac Output; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007444:Inulin; D007668:Kidney / Q000187:drug effects*; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D009458:Neuroleptanalgesia / Q000009:adverse effects*; D009994:Osmolar Concentration; D014655:Vascular Resistance; D014882:Water-Electrolyte Balance; D010130:p-Aminohippuric Acid
chemical_list: D007444:Inulin; D010130:p-Aminohippuric Acid