Zinc-induced protection against cadmium alteration of drug action.
Pretreatment of male rats with cadmium acetate potentiates the duration of hexobarbital hypnosis and inhibits the rate of hepatic microsomal drug metabolism. Pretreatment of rats with zinc acetate protects against these alterations in drug action elicited by cadmium.
D000818:Animals; D002104:Cadmium / Q000037:antagonists & inhibitors*; D006591:Hexobarbital / Q000378:metabolism / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051381:Rats; D012890:Sleep / Q000187:drug effects; D015032:Zinc / Q000494:pharmacology*
D002104:Cadmium; D006591:Hexobarbital; D015032:Zinc