Metabolites of 1,2-epoxy-3-phenoxy- and 1,2-epoxy-3-(p-nitrophenoxy)propane.
1. Rabbits and rats dosed with 1,2-epoxy-3-phenoxypropane excrete 2-hydroxy-3-phenoxypropionic acid and N-acetyl-S-(2-hydroxy-3-phenoxypropyl)-L-cysteine. 2. Rabbits and rats dosed with 1,2-epoxy-3-(p-nitrophenoxy)propane excrete 2-hydroxy-3-(p-nitrophenoxy)propionic acid, N-acetyl-S-[2-hydroxy-3-(p-nitrophenoxy/propyl)propyl]-L-cysteine and p-nitrophenol. 3. The administration of either epoxide to the rat produces a marked fall in hepatic GSH level. 4. The biliary excretion of metabolites of 1,2-epoxy-3-(p-nitrophenoxy)-propane is described.
D000818:Animals; D001646:Bile / Q000378:metabolism; D001711:Biotransformation; D002845:Chromatography; D004852:Epoxy Compounds / Q000378:metabolism* / Q000494:pharmacology; D004988:Ethers, Cyclic / Q000378:metabolism*; D005260:Female; D005978:Glutathione / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D009596:Nitrophenols / Q000378:metabolism* / Q000494:pharmacology; D010636:Phenols / Q000378:metabolism* / Q000494:pharmacology; D011817:Rabbits; D051381:Rats
D004852:Epoxy Compounds; D004988:Ethers, Cyclic; D009596:Nitrophenols; D010636:Phenols; C007606:1,2-epoxy-3-(p-nitrophenoxy)propane; D005978:Glutathione