title: [Non-secreting myeloma].
abstract: On the basis of a personal observation, the cases of "non secretory" multiple myeloma reported in the literature are reviewed. A myeloma classification based upon the production and excretion of monoclonal proteins by neoplastic plasmacells is presented together with an evaluation of the different possible pathogenetic mechanisms. The diagnostic criteria of "non secretory" myeloma are discussed and its main clinical problems analyzed.
mesh_terms: D006801:Humans; D007136:Immunoglobulins / Q000096:biosynthesis; D009101:Multiple Myeloma / Q000145:classification* / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D009363:Neoplasm Proteins / Q000378:metabolism*
chemical_list: D007136:Immunoglobulins; D009363:Neoplasm Proteins
vernacular_title: Il mieloma "non secernente".