title: Control of glucose metabolism in isolated acini of the lactating mamary gland of the rat. Effects of oleate on glucose utilization and lipogenesis.
abstract: Oleate (1mM) had only small inhibitory effects on glucose utilization and lipogenesis in acini isolated from rat mammary gland. Esterification of [1-14C]oleate was unaffected by insulin but were decreased by 60% by acetoacetate (2mM). Glycerol (1mM), but not insulin, relieved this inhibition. These experiments provide further support for the role of acetoacetate in regulating substrate utilization by the gland.
mesh_terms: D000090:Acetoacetates / Q000494:pharmacology; D000818:Animals; D005260:Female; D005947:Glucose / Q000378:metabolism*; D005990:Glycerol / Q000494:pharmacology; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology; D007774:Lactation; D008055:Lipids / Q000096:biosynthesis*; D008321:Mammary Glands, Animal / Q000187:drug effects / Q000378:metabolism*; D009829:Oleic Acids / Q000494:pharmacology*; D011247:Pregnancy; D051381:Rats
chemical_list: D000090:Acetoacetates; D007328:Insulin; D008055:Lipids; D009829:Oleic Acids; D005947:Glucose; D005990:Glycerol