Further investigations of indomethacin and intestinal ulcers in the rat.
The lower incidence of indomethacin-induced intestinal ulcers in fasted as compared to fed rats must be attributed to factor(s) other than changes in bile flow and composition. Experimental evidence and data in the literature rather suggest that the amount of food present in the gastrointestinal tract at the time indomethacin was given may influence ulcer formation by affecting the duration and degree enterohepatic circulation of this compound.
D000818:Animals; D001646:Bile / Q000187:drug effects; D002635:Chenodeoxycholic Acid / Q000494:pharmacology; D004435:Eating; D005260:Female; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D010437:Peptic Ulcer / Q000139:chemically induced*; D051381:Rats; D013270:Stomach / Q000502:physiology; D013997:Time Factors
D002635:Chenodeoxycholic Acid; D007213:Indomethacin