The effect of taurine on kindled seizures in the rat.
Recently, it has been reported that taurine, an amino acid with anticonvulsant properties, does not suppress experimental seizures generated by the "kindling" technique. This finding seems somewhat paradoxical since taurine antagonizes other sorts of experimental convulsion and since kindled seizures are easily suppressed by other anticonvulsant drugs. Further tests were therefore conducted during which taurine's anticonvulsant effects were assessed: (1) when kindling stimulation was dropped to near-threshold levels; (2) when cortical as well as limbic kindled foci were stimulated; (3) when developing as well as fully kindled seizures were involved; and (4) when taurine was introduced directly into the ventricles of the brain. Even in these tests which were specifically designed to favour the appearance of anticonvulsant effects, no taurine antagonism of kindled seizures was found.
D000679:Amygdala / Q000502:physiology; D000818:Animals; D000927:Anticonvulsants; D002540:Cerebral Cortex / Q000502:physiology; D004597:Electroshock; D007276:Injections, Intraventricular; D007279:Injections, Subcutaneous; D008297:Male; D051381:Rats; D012640:Seizures / Q000209:etiology / Q000503:physiopathology*; D013654:Taurine / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
D000927:Anticonvulsants; D013654:Taurine