Inability of vitamin A deficiency to alter benzo(a)pyrene metabolism in Syrian hamsters.
Syrian golden hamsters were placed on a control or vitamin A-deficient diet. When their serum vitamin A content was significantly reduced, i.e., to less than 10% of controls, the hamsters were killed and lung aryl hydrocarbon hydroxylase activity and metabolism of benzo(a)pyrene were determined. The benzo(a)pyrene metabolite profile was similar with control and A-deficient systems, and only few quantitative differences were noted. Addition of beta-retinyl acetate to the in vitro incubations did not substantially affect benzo(a)pyrene metabolism.
D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000378:metabolism; D001580:Benzopyrenes / Q000378:metabolism*; D006224:Cricetinae; D004224:Diterpenes; D066298:In Vitro Techniques; D008168:Lung / Q000378:metabolism*; D008297:Male; D008647:Mesocricetus; D008861:Microsomes / Q000378:metabolism; D000084562:Retinyl Esters; D014801:Vitamin A / Q000031:analogs & derivatives / Q000494:pharmacology; D014802:Vitamin A Deficiency / Q000378:metabolism*
D001580:Benzopyrenes; D004224:Diterpenes; D000084562:Retinyl Esters; D014801:Vitamin A; C009166:retinol acetate; D001189:Aryl Hydrocarbon Hydroxylases