[Neuro-hormonal mechanisms of hypothalamic influences on the tonus of cerebral vessels].
In anesthetized cats, stimulation of supraoptic nuclei (SON) and dorso-lateral hypothalamus (DLH) led to cerebral vasoconstriction if not prevented by alpha-adrenoblocking drugs. The SON stimulation entailed activation of both the synthesis and the transport of neurosecretory substances and increased the neurohormone release into the blood flow. Delayed ("hormonal") vasoconstrictory responses occurred in these experiments. Stimulation of the preoptic area evoked moderate cerebral vasodilatation, later decreased or blocked by atropine. Neurohormone (vasopressin) seems to participate in the vasoconstriction evoked by the SON stimulation.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000098:blood supply*; D001931:Brain Mapping; D002415:Cats; D002746:Chlorpromazine / Q000494:pharmacology; D004558:Electric Stimulation; D004837:Epinephrine / Q000502:physiology; D007031:Hypothalamus / Q000502:physiology*; D008297:Male; D011301:Preoptic Area / Q000502:physiology; D013495:Supraoptic Nucleus / Q000502:physiology; D013564:Sympathetic Nervous System / Q000502:physiology; D014661:Vasoconstriction; D014667:Vasopressins / Q000502:physiology
D014667:Vasopressins; D002746:Chlorpromazine; D004837:Epinephrine
Neĭro-gormonal'nye mekhanizmy gipotalamicheskikh vliianiĭ na tonus mozgovykh sosudov.