Cytogenetic study in spermatocytes of mice and Chinese hamsters after treatment with isoniazid (INH).
Meiotic chromosomes of spermatocytes from INH-treated male mice and Chinese hamsters were analysed for chromosome aberrations in diakinesis-metaphase I and metaphase II. The experiments were performed in two laboratories while a third laboratory participated in the chromosome evaluation. No enhancement of chromosome aberrations could be observed after acute treatment of early primary spermatocytes or chronic treatment of spermatogonia with INH.
D000818:Animals; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects; D006224:Cricetinae; D007538:Isoniazid / Q000494:pharmacology*; D008297:Male; D008540:Meiosis; D008677:Metaphase; D051379:Mice; D013090:Spermatocytes / Q000187:drug effects*; D013094:Spermatozoa / Q000187:drug effects*; D013997:Time Factors
D007538:Isoniazid