[Inhibition of the carrageenen-induced inflammatory rat paw oedema by systemic application of rat fibrinogen and fibrinopeptides (author's transl)].
The acute inflammatory rat paw oedema induced by subplantar injection of carrageenan was significantly inhibited by intraperitoneal injection of rat fibrinogen, intraperitoneal and intracardial injection of fibrinoepetides A and B. In contrast the fibrin split products derived from plasmin digestion proved to be ineffective.
D000818:Animals; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D005340:Fibrinogen / Q000008:administration & dosage*; D005344:Fibrinopeptide A / Q000008:administration & dosage; D005345:Fibrinopeptide B / Q000008:administration & dosage; D006614:Hindlimb; D007274:Injections, Intraperitoneal; D051381:Rats; D011919:Rats, Inbred Strains
D005344:Fibrinopeptide A; D005345:Fibrinopeptide B; D002351:Carrageenan; D005340:Fibrinogen
Hemmung des Carrageenan-induzierten entzündlichen Rattenpfotenödems durch systemische Applikation von Rattenfibrinogen und -fibrinopeptiden.