Effects of hCG on serum levels of testosterone, dihydrotestosterone and androstenedione in male mice.
The concentrations of testosterone (T), 5alpha-dihydrotestosterone (5alpha-DHT) and delta4-androstenedione (delta4 A) in the circulating blood were increased by a single subcutaneous injection of 10 IU of hCG in the mouse. The response of androgen synthesis to hCG stimulation was rapid and persisted over a period of 96 h. The increased supply of T to the peripheral organ(s) under the stimulation of hCG might contribute to an increase in circulating 5alpha-DHT. However, the changes in T/5alpha-DHT ratio implies that the stimulation of T and 5alpha-DHT production by hCG were not of the same degree.
D000735:Androstenedione / Q000097:blood*; D000818:Animals; D006063:Chorionic Gonadotropin / Q000494:pharmacology*; D013196:Dihydrotestosterone / Q000097:blood*; D007700:Kinetics; D008297:Male; D051379:Mice; D013739:Testosterone / Q000097:blood*
D006063:Chorionic Gonadotropin; D013196:Dihydrotestosterone; D013739:Testosterone; D000735:Androstenedione