Synthesis and hypoglycemic activity of some substituted 2-arylthiazolo[3,2-a]pyridinium salts.
A series of substituted 2-arylthiazolo[3,2-a]pyridinium salts (1a-q) was prepared by known methods and tested for hypoglycemic activity in 48-h fasted rats. Two compounds, 2-phenylthiazolo- and 8-methyl-2-phenythiazolo[3,2-a]pyridinium perchlorate (1a and 1q), showed consistent hypoglycemic activity in this screen, demonstrating that a high degree of structural specificity was required for hypoglycemic activity. At higher doses the hypoglycemic activity of 1a and 1q was associated with elevated levels of hepatic triglycerides.
D000818:Animals; D007004:Hypoglycemic Agents / Q000138:chemical synthesis*; D066298:In Vitro Techniques; D008297:Male; D008722:Methods; D011726:Pyridinium Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship
D007004:Hypoglycemic Agents; D011726:Pyridinium Compounds