[The action of pyruvate kinase and phosphoenolpyruvate on the development of experimental thrombosis].
Tests set up on rats and rabbits showed the ability of phospho-enolpyruvate and pyruvate-kinase to lower the aggregation of thrombocytes and prevent formation of experimental microthrombosis. The joint introduction of these compounds in most experiments resulted in potentiation of the antithrombotic effect.
D000818:Animals; D004357:Drug Synergism; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D010728:Phosphoenolpyruvate / Q000494:pharmacology* / Q000627:therapeutic use; D010974:Platelet Aggregation / Q000187:drug effects*; D011770:Pyruvate Kinase / Q000494:pharmacology* / Q000627:therapeutic use; D011817:Rabbits; D051381:Rats; D013927:Thrombosis / Q000097:blood / Q000517:prevention & control*
D005343:Fibrinolytic Agents; D010728:Phosphoenolpyruvate; D011770:Pyruvate Kinase
Vliianie piruvatkinazy i fosfoenolpiruvata na formirovanie eksperimental'nogo tromboza.