Transient heterosynaptic depression in the hippocampal slice.
Two independent, excitatory, monosynaptic afferent fiber systems projecting onto basal and apical dendritic layers of the CA1 sub-field of the hippocampus were tested for interactive effects. Long-term potentiation of either of the pathways was accompanied by a transient depression in the other pathway. Similar transient depression could be elicited by antidromic stimulation of the CA1 cells. No long-term heterosynaptic effects were observed.
D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D004558:Electric Stimulation / Q000379:methods; D005071:Evoked Potentials; D006624:Hippocampus / Q000502:physiology*; D008297:Male; D008564:Membrane Potentials; D009433:Neural Inhibition; D009474:Neurons / Q000502:physiology; D051381:Rats; D013569:Synapses / Q000502:physiology*