Brain edema: induction in cortical slices by polyunsaturated fatty acids.
The presence of polyunsaturated and saturated fatty acids in leukocytic membranes prompted study of their possible role in the induction of brain edema. Polyunsaturated fatty acids including sodium arachidonate, sodium linoleate, sodium linolenate, and docasahexaenoic acids induced edma in slices of rat brain cortex. This cellular edema was specific, since neither saturated fatty acids nor a fatty acid containing a single double bond had such effect.
D000818:Animals; D001095:Arachidonic Acids; D001929:Brain Edema / Q000139:chemically induced*; D002540:Cerebral Cortex; D003902:Detergents; D004305:Dose-Response Relationship, Drug; D005231:Fatty Acids, Unsaturated; D006098:Granulocytes / Q000502:physiology; D006880:Hydroxy Acids; D066298:In Vitro Techniques; D011453:Prostaglandins; D051381:Rats; D012967:Sodium Dodecyl Sulfate; D014883:Water-Electrolyte Imbalance / Q000139:chemically induced
D001095:Arachidonic Acids; D003902:Detergents; D005231:Fatty Acids, Unsaturated; D006880:Hydroxy Acids; D011453:Prostaglandins; D012967:Sodium Dodecyl Sulfate