[Effect of selenium on the enzymatic transformation of retinal and vitamin A assimilation].
The effect of sodium selenite on the enzymatic oxidation of retinal in vitro and vitamin A accumulation in the rat liver was examined. Selenium as sodium selenite at concentrations of 0.5--2.5 microgram/ml inhibited significantly (40--45%) the enzymatic irreversible oxidation of retinal. Dietary supplements of sodium selenite at a dose of 50--250 microgram/kg body weight caused an almost two-fold increase of the vitamin A content in the rat liver as compared with the controls that were given no selenium.
D000818:Animals; D001711:Biotransformation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D010084:Oxidation-Reduction / Q000187:drug effects; D051381:Rats; D012172:Retinaldehyde / Q000378:metabolism*; D012643:Selenium / Q000494:pharmacology*; D014801:Vitamin A / Q000031:analogs & derivatives*
D014801:Vitamin A; D012643:Selenium; D012172:Retinaldehyde
Vliianie selena na énzimaticheskie prevrashcheniia retinalia i usvoenie vitamina A.