[Changes of various indicators of brain metabolism in excessive stimulation of the body and the effect of etimizol on these changes].
In case of an excessive irritation (a 3-hour electrical stimulation) of the organism there were observed marked changes in the brain metabolism in rats. These changes were expressed in the exhaustion of noradrenaline stores and disturbances of energy metabolism, leading to reduction of the creatinphosphate level. Preliminary (before the electrical stimulation) administration of ethimizol prevented deficiency of noradrenaline and creatinphosphate in the brain tissue of the animals subjected to the excessive irritation.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D004558:Electric Stimulation; D004734:Energy Metabolism; D005042:Etimizol / Q000494:pharmacology*; D006019:Glycolysis / Q000187:drug effects; D007093:Imidazoles / Q000494:pharmacology*; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010725:Phosphocreatine / Q000378:metabolism; D010758:Phosphorus / Q000378:metabolism; D051381:Rats
D007093:Imidazoles; D010725:Phosphocreatine; D010758:Phosphorus; D005042:Etimizol; D009638:Norepinephrine
Izmeneniia nekotorykh pokazateleĭ metabolizma golovnogo mozga pri chrezvychaĭnom vozdeĭstvii na organizm i vliianie etimizola na eti izmeneneniia.