title: [Influence of ions on the activity of rat parotid DNase].
abstract: The activity of DNase, purified from rat parotid saliva was studied as affected by 7 metal ions. It is found that Mg2+ activated the salivary DNase. Ca2+ and Ba2+ in concentrations exceeding 10(-3) M revealed the inhibitory action, while Zn2+ and Cu2+ under these conditions have an essential effect on the enzyme activity. Al3+ produced no significant effect on the DNase activity. The rat parotid DNase activity is the highest in imidazol and tris-HCl buffers (pH 7.2-7.4) in the presence of 2.5 . 10(-2) M of Mg2+.
mesh_terms: D000535:Aluminum / Q000494:pharmacology; D000818:Animals; D002413:Cations, Divalent / Q000494:pharmacology*; D003851:Deoxyribonucleases / Q000378:metabolism*; D005260:Female; D008297:Male; D010306:Parotid Gland / Q000201:enzymology*; D051381:Rats; D012463:Saliva / Q000201:enzymology
chemical_list: D002413:Cations, Divalent; D000535:Aluminum; D003851:Deoxyribonucleases
vernacular_title: Vliianie ionov na dezoksiribonykleaznuiu aktivnost' okoloushnoĭ zhelezy krys.