Method for controlled establishment of steady-state plasma levels through multiple dosing.
A specific dosage schedule is designed for the case of multiple dosing with the aim of achieving the desired steady-state blood level in a predetermined time interval. The method is based on the administration of nonuniform doses at uniform dosage intervals during the saturation time. To calculate the doses a nonlinear equation must be solved. The theory is illustrated by a quantitative example (digitoxin).
D004334:Drug Administration Schedule; D006207:Half-Life; D007408:Intestinal Absorption; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000097:blood*; D013997:Time Factors
D004364:Pharmaceutical Preparations