Protection of the mouse from genetic radiation damage by an optimal-dose-ratio combination of ATP, AET, and serotonin.
The study concerned antiradiation effects in germ-cell genetic structures produced by a combination of ATP, AET, and serotonin at dose ratio optimal for lethality namely, 45:3:1, as arrived at in our previous work. Such a combination was found to reduce by a factor of 2 the translocation yields observed after 400 R X-rays to mouse spermatogonia. In terms of animal survival, ATP has been shown to contribute little to total protection achieved by the same combination; in terms of genetic damage; however, the role of ATP proved essential. Removal of ATP from the combination led to a significant reduction in protective effect.
D000255:Adenosine Triphosphate / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011837:Radiation-Protective Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D012701:Serotonin / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D013093:Spermatogonia / Q000187:drug effects / Q000528:radiation effects; D014178:Translocation, Genetic / Q000187:drug effects*; D014965:X-Rays; D000338:beta-Aminoethyl Isothiourea / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D004338:Drug Combinations; D011837:Radiation-Protective Agents; D000338:beta-Aminoethyl Isothiourea; D012701:Serotonin; D000255:Adenosine Triphosphate