title: Fetal respiratory distress causing CNS and inner ear hemorrhage.
abstract: Fifty-two consecutive temporal bones of infants who died neonatally, or in utero of natural causes, were studied. Complete autopsies were performed. Twenty-eight infants had a variety of pulmonary disorders which resulted in severe respiratory distress prior to their death. Of these, the majority had bleeding intracranially and into the inner ear. There were five major pathways of central nervous system and subarachnoid hemorrhage involvement of the inner ear: 1) the modiolus, 2) cochlear aqueduct, 3) retrograde via the cochlear vein, 4) episodes of spontaneous bleeding into various compartments of the inner ear, and 4) hemorrhage via the otic capsule. The remaining 24 infants died of other natural causes. Two had CNS bleeding with no extension to the inner ear. We propose that there is a syndrome which consists of 1) neonatal respiratory distress, 2) intracranial hemorrhage, and 3) bleeding into the inner ear--an extension of a subarachnoid or subependymal matrix bleeding diathesis.
mesh_terms: D002543:Cerebral Hemorrhage / Q000209:etiology* / Q000473:pathology; D007758:Ear, Inner / Q000473:pathology; D005260:Female; D005315:Fetal Diseases / Q000150:complications* / Q000473:pathology; D006470:Hemorrhage / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007759:Labyrinth Diseases / Q000209:etiology* / Q000473:pathology; D008168:Lung / Q000473:pathology; D008297:Male; D011247:Pregnancy; D012127:Respiratory Distress Syndrome, Newborn / Q000150:complications* / Q000473:pathology; D013345:Subarachnoid Hemorrhage / Q000209:etiology; D013577:Syndrome