Concentration-dependent conformational transition of alpha-elastin in aqueous solution.
Circular dichroism measurements on aqueous solutions of alpha-elastin have given evidence of beta-bend structure at elevated concentrations. When Ca2+ was added, the concentration-dependent conformational transition was somewhat inhibited and the binding of the metal ion was shown, by means of equilibrium dialysis, to be essentially independent from alpha-elastin concentration in the range of 1 to 10 mg/ml. The results obtained are discussed in connection with the elasticity and calcification of elastin.
D000818:Animals; D002118:Calcium; D002417:Cattle; D002942:Circular Dichroism; D004549:Elastin; D011487:Protein Conformation; D014867:Water
D014867:Water; D004549:Elastin; D002118:Calcium