Tryptophan metabolism in Japanese and British women and its relationship to endogenous steroid levels.
The excretion of the tryptophan metabolites L-kynurenine, 3-hydroxykynurenine, 3-hydroxyanthranilic acid and xanthurenic acid, by normal Japanese and British pre-menopausal, menopausal and post-menopausal women was measured after a loading dose of L-tryptophan. No significant difference was found between the mean excretion levels of the two races. A correlation with the level of plasma oestradiol and the excretion of L-kynurenine and also with the total of the four metabolites was found in pre-menopausal British women but not in Japanese women.
D015095:3-Hydroxyanthranilic Acid / Q000652:urine; D044466:Asian People; D001943:Breast Neoplasms / Q000453:epidemiology / Q000378:metabolism; D004958:Estradiol / Q000097:blood; D005260:Female; D006728:Hormones / Q000097:blood / Q000502:physiology*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007564:Japan; D007737:Kynurenine / Q000031:analogs & derivatives / Q000652:urine; D008593:Menopause; D014364:Tryptophan / Q000378:metabolism*; D006113:United Kingdom; D044465:White People; D014977:Xanthurenates / Q000652:urine
D006728:Hormones; D014977:Xanthurenates; D015095:3-Hydroxyanthranilic Acid; D007737:Kynurenine; D004958:Estradiol; D014364:Tryptophan; D006854:Hydrocortisone