Inhibition of testosterone 5alpha-reductase activity and growth of accessory sex tissues in castrated male mice.
The steroid 4-androsten-3-one-17beta-carboxylic acid (17betaC) reduced the growth-promoting actions of testosterone, but not those of DHT in accessory sex tissues of castrated mice. The 5alpha-reduction of testosterone to DHT in these tissues was also reduced by 17betaC treatment, suggesting that DHT formation is a required step in the mechanism of action of testosterone.
D058891:5-alpha Reductase Inhibitors; D000736:Androstenes; D000818:Animals; D002369:Castration; D013196:Dihydrotestosterone / Q000494:pharmacology; D005837:Genitalia, Male / Q000187:drug effects / Q000254:growth & development*; D008297:Male; D051379:Mice; D010088:Oxidoreductases / Q000037:antagonists & inhibitors*; D013268:Stimulation, Chemical; D013739:Testosterone / Q000494:pharmacology
D058891:5-alpha Reductase Inhibitors; D000736:Androstenes; D013196:Dihydrotestosterone; D013739:Testosterone; D010088:Oxidoreductases