title: Action of glutamic acid and of some glutamate analogues on the molluscan central neurones.
abstract: The effects of L-glutamic acid and of some glutamate analogues have been studied on the central nervous system of the snail Heobania vermiculata, using conventional electrophysiological techniques. The glutamate H-response had the mean equilibrium value of -(57 +/- 4) mV and was associated with a Cl- conductance change. The D-response to glutamate application showed an involvement of sodium ions. Aspartate was agonist of glutamate action and displayed similar equilibrium value of the H-response, whereas quisqualate H-response was 'non-invertible'.
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000187:drug effects*; D004553:Electric Conductivity; D005071:Evoked Potentials / Q000187:drug effects; D005971:Glutamates / Q000494:pharmacology*; D066298:In Vitro Techniques; D007478:Iontophoresis; D009474:Neurons / Q000187:drug effects*; D012908:Snails
chemical_list: D005971:Glutamates