Protein binding of drugs.
Basic considerations involved in the interaction of drugs with proteins are reviewed. The important role of the concentration of unbound drug in determining therapeutic and toxicologic effects is emphasized. Ultra-filtration is suggested to be the method of choice for the determination of concentrations of unbound drug in plasma in clinical practice.
D001665:Binding Sites; D001692:Biological Transport; D001798:Blood Proteins / Q000378:metabolism*; D005110:Extracellular Space / Q000378:metabolism; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000097:blood / Q000378:metabolism*; D011485:Protein Binding; D014116:Toxicology; D014462:Ultrafiltration
D001798:Blood Proteins; D004364:Pharmaceutical Preparations