[The action of 9 alpha-fluorohydrocortisone on some aspects of water-electrolyte metabolism in animals].
This mineralocorticoid effect of different doses of the synthetic hormone 9-alpha-fluorhydrocortisone was studied. The introduction of the drug to intact animals per os was found not to produce any sodium-retention effect. A single adminstration of 9-alpha-fluorhydrocortisone causes an intensified excretion of water, sodium potassium with the urine. A course-wise application of the hormone brings about the development of hypokaliemia.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005438:Fludrocortisone / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D007008:Hypokalemia / Q000139:chemically induced; D011188:Potassium / Q000652:urine; D051381:Rats; D012964:Sodium / Q000652:urine; D013997:Time Factors; D014882:Water-Electrolyte Balance / Q000187:drug effects*
D012964:Sodium; D011188:Potassium; D005438:Fludrocortisone
Deĭstvie 9-al'fa-ftorgidrokortizona na nekotorye pokazateli vodno-solevogo obmena u zhivotnykh.