The neutrophil adherence assay as a method for detecting unique anti-inflammatory agents.
Neutrophil adhesiveness is an important component of the pathophysiology of the inflammatory process. Modulation of this function could result in a reduction in the degree of inflammation and connective tissue damage. A simple technique using filtration of whole blood through nylon fiber columns has been developed to study the effect of anti-inflammatory agents on the adherence of rat peripheral blood neutrophils. Gold and chloroquine, in addition to many standard anti-inflammatory drugs, have been shown to cause inhibition of neutrophil adherence. Measurement of this parameter of cell behavior has the potential of detecting anti-inflammatory agents not normally effective in the standard animal models.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D066298:In Vitro Techniques; D008297:Male; D009504:Neutrophils / Q000187:drug effects*; D051381:Rats
D000893:Anti-Inflammatory Agents