Drug metabolism in a case of progeria.
A case of premature ageing (progeria) in a 3-year-old Indian child is described. The conjugations of paracetamol with glucuronic acid and sulphate, of benzoic acid with glycine and of phenylacetic acid with glutamine have been investigated in this child, in view of suggestions that these reactions are impaired in old age. The results suggest that the glucuronic acid conjugation pathway may be quantitatively less important in the progeric child than in normal children and adults.
D000082:Acetaminophen / Q000378:metabolism*; D001565:Benzoates / Q000378:metabolism*; D002675:Child, Preschool; D006801:Humans; D008297:Male; D010648:Phenylacetates / Q000378:metabolism*; D011371:Progeria / Q000378:metabolism*; D012016:Reference Values
D001565:Benzoates; D010648:Phenylacetates; D000082:Acetaminophen