Distribution and metabolism of gastrin. An experimental study of the  fate of 123 I-gastrin in the rat as studied by external detection with a gamma camera.
In anesthetized rats, the activity distribution of intravenously administered synthetic human gastrin I, labelled with 123 I, was recorded externally by a gamma camera. In intact rats activity was found to accumulate in the kidneys and later in the stomach. After bilateral nephrectomy, the gastric apperance of activity was delayed. In both cases, the gastric activity is considered to emanate not from intact 123 I-gastrin but from free iodide, split off during gastrin degradation. The renal accumulation of gastrin in intact animals as well as the delayed gastric uptade of iodide in nephrectomized animals support the hypothesis that the kidneys are important organs for gastrin metabolism.
D000818:Animals; D005069:Evaluation Studies as Topic; D005720:Gamma Rays; D005755:Gastrins / Q000378:metabolism*; D006801:Humans; D007457:Iodine Radioisotopes; D007813:Laparotomy; D008297:Male; D008722:Methods; D009392:Nephrectomy; D051381:Rats; D014018:Tissue Distribution
D005755:Gastrins; D007457:Iodine Radioisotopes