Immune responses of cows to a chemically modified anaplasma antigen.
Cows were vaccinated at 0 and 28 days with either a standard or a chemically modified anaplasma antigen. The humoral antibody response was measured by the anaplasma complement-fixation and card agglutination tests. The antibody response to bovine erythrocyte antigens was also evaluated. Peripheral blood leukocytes were collected for an in vitro lymphocyte-transformation test. Both groups of vaccinated cows developed a significant cell-mediated response as measured by lymphocyte-transformation test. However, only the cows given the standard anaplasma antigen developed anaplasma antibody and significant titer of bovine erythrocyte antibodies. Vaccinated and control cows were challenge exposed 1 month after the 2nd antigen injection. The vaccinated cows developed lower levels of parasitemia than did the control nonvaccinated cows.
D000372:Agglutination Tests; D000709:Anaplasma / Q000276:immunology*; D000712:Anaplasmosis / Q000517:prevention & control; D000818:Animals; D000917:Antibody Formation; D000942:Antigens, Bacterial; D002417:Cattle / Q000276:immunology*; D002418:Cattle Diseases / Q000517:prevention & control; D003168:Complement Fixation Tests; D005260:Female; D008213:Lymphocyte Activation
D000942:Antigens, Bacterial