Synthesis of the urinary glucuronic acid conjugate of N-hydroxy-4-aminobiphenyl.
The glucuronic acid conjugate of N-hydroxy-4-aminobiphenyl believed to be the carrier form responsible for transporting the active N-hydroxy compound from its site of formation in the liver to its site of carcinogenic action in the bladder has been prepared synthetically. The synthetic conjugate is identical by infrared and chromatographic analyses with the conjugate isolated from urine, thus unequivocally establishing its structure as an N--C conjugate, sodium (N,4-biphenyl-N-hydroxy-D-glucuronosylamine).
D000611:Aminobiphenyl Compounds / Q000138:chemical synthesis*; D005965:Glucuronates / Q000138:chemical synthesis*; D005966:Glucuronidase; D006868:Hydrolysis; D013055:Spectrophotometry, Infrared
D000611:Aminobiphenyl Compounds; D005965:Glucuronates; C016267:N,4-biphenyl-N-hydroxy-D-glucuronosylamine; D005966:Glucuronidase