[Antitumor activity of cytostatics on a newly transplanted tumor in mice, myosarcoma ISM].
The author examined the action of 14 known antitumor preparations on mice BAIB/c with newly transplanted tumour occurred after induction with tetrachlormethane. The tumour myosarcoma ISM showed high sensitivity to cyclophosphamide, administration of which caused complete inhibition of tumour growth and regression of tumours. A comparative high antitumour effect was found after usage of sarcolysine, brunemycine and mitomycine C (over 70% of inhibition). There was a moderately manifested inhibition of the tumour growth (around 50%) after administration of cytostatics degranol, purinetol, 5-fluorouracyl and ftorafur. The substances alexan, rubomycine and 1-(2-chlorethy)-3-cyclohexyl-1-nitrosourea were without effect on myosarcom ISM. The obtained data showed that then tumour well differentiated substances in accordance with their action. It is a prorer model for thorough investigation of antitumour substances.
D000477:Alkylating Agents / Q000627:therapeutic use; D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D051379:Mice; D008807:Mice, Inbred BALB C; D009217:Myosarcoma / Q000188:drug therapy*; D009368:Neoplasm Transplantation; D012513:Sarcoma, Experimental / Q000188:drug therapy
D000477:Alkylating Agents; D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents
Izuchvane protivotumornata aktivnost na tsitostatitsi vurkhu nov transplantiruem tumor u mishki miosarkom ISM.