Synthesis and turnover of 3H-5-hydroxytryptamine in the later cerebroventricle.
The lateral cerebroventricle was perfused using two different labelling procedures in three separate experiments on 5-hydroxytryptamine metabolism. The sensitivity of 5-hydroxytryptamine metabolism to various drugs was subsequently determined. The results demonstrate that two serotonin reuptake blockers, imipramine and fluoxetine, increase the efflux of 3h-5-hydroxytryptamine into the ventricle without affecting the efflux of 3H-5-hydroxyindoleacetic acid. BL-3912 A, a drug with weak serotonin agonist activity, also increased the efflux of 3H-5-hydroxytryptamine into the ventricle.
D000818:Animals; D002552:Cerebral Ventricles / Q000378:metabolism*; D002855:Chromatography, Thin Layer; D005260:Female; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007099:Imipramine / Q000494:pharmacology; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D012701:Serotonin / Q000096:biosynthesis / Q000378:metabolism*; D013997:Time Factors; D014364:Tryptophan / Q000008:administration & dosage / Q000378:metabolism
D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D014364:Tryptophan; D007099:Imipramine