Action of surface-active substances of biological membranes. III. Comparison of hemolytic activity of ionic and nonionic surfactants.
The hemolytic action of a number of homologous series of cationic surfactants on human erythrocytes was measured. The hemolytic effects of anionic, nonionic and cationic surface-active agents are compared. The relationship which exists between the key physicochemical properties of surfactants (critical micelle concentration, hydrophile-lipophile balance) and their hemolytic capacities is discussed. The parameters required to compare the actions of various surfactants on different cellular membranes are considered in relation to the study of the correlation between the surfactant lytic effects and the features of the membrane molecular organization.
D004912:Erythrocytes / Q000187:drug effects*; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D007700:Kinetics; D008823:Micelles; D013329:Structure-Activity Relationship; D013501:Surface-Active Agents / Q000494:pharmacology*
D008823:Micelles; D013501:Surface-Active Agents