title: The effect of endogenous and exogenous GABA on the level and turnover of noradrenaline and dopamine in the rat brain.
abstract: The effect of endogenous and exogenous GABA on the level and turnover of noradrenaline and dopamine in the rat brain. Acta Physiol. Pol., 1978, 29 (2): 117--121. GABA administered to the lateral ventricle of the rat brain (i.v.c.) in doses of 200 and 600 microgram decreased the level of noradrenaline and had no effect on dopamine level. A similar effect was obtained after raising the level of endogenous GABA in the brain by means of intraperitoneal hydroxylamine (Hx) in doses of 50 and 75 mg/kg. It was also observed that GABA given i.v.c. in a dose of 600 mg/kg reduces the turnover of dopamine in the brain.
mesh_terms: D000613:Aminobutyrates / Q000502:physiology*; D000818:Animals; D001923:Brain Chemistry; D002552:Cerebral Ventricles; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D006898:Hydroxylamines / Q000494:pharmacology; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D013974:Thyroxine / Q000031:analogs & derivatives / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology / Q000502:physiology*
chemical_list: D000613:Aminobutyrates; D006898:Hydroxylamines; D005680:gamma-Aminobutyric Acid; D013974:Thyroxine; D004298:Dopamine; D009638:Norepinephrine