Specific suppression of anti-hapten reaginic antibody titers with hapten-coated liposomes.
Reaginic antibodies to DNP and ovalbumin (OA) were induced in B6D2F1 mice by a single i.p. injection of 1 microgram of DNP3-OA suspended with 1 mg of A1(OH)3 in 0.5 ml of saline. The anti-DNP reaginic antibody titers were markedly depressed by treatment of mice with DNP-coated liposomes. This treatment, however, did not affect the level of antibody formation to OA.
D015119:Aminocaproic Acid / Q000276:immunology; D000818:Animals; D000917:Antibody Formation; D000918:Antibody Specificity; D004136:Dinitrobenzenes / Q000276:immunology; D006241:Haptens; D007165:Immunosuppression Therapy; D008081:Liposomes; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D010047:Ovalbumin / Q000276:immunology; D010714:Phosphatidylethanolamines / Q000276:immunology; D051381:Rats; D011935:Reagins / Q000096:biosynthesis*
D004136:Dinitrobenzenes; D006241:Haptens; D008081:Liposomes; D010714:Phosphatidylethanolamines; D011935:Reagins; D010047:Ovalbumin; D015119:Aminocaproic Acid