Acid and neutral lipases of cultured adipocytes of infants and children.
In order to determine whether the mobilization of intracellular triglycerides observed in cultured human adipocytes is associated with changes in the activities of acid and neutral lipases, the activities of both enzymes were measured weekly on cultured adipocytes for several months. The activity of acid lipase was initially very low, but rose to levels 40 times the original activity within 3 months. The activity of neutral lipase decreased rapidly within the first 2-4 weeks and remained at approximately 25% of original levels thereafter.
D000273:Adipose Tissue / Q000201:enzymology*; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008049:Lipase / Q000378:metabolism*; D008053:Lipid Mobilization; D014280:Triglycerides / Q000378:metabolism*
D014280:Triglycerides; D008049:Lipase