[Radioprotective and toxicological properties on some 4-oxyhexa- and 1,2,3,6-tetrahydroprimidine-2-thione derivatives].
Test on mice demonstrated the radio-protective activity of 12 derivatives of 4-oxyhexahydropyrimidinethione-2 and 1,2,3,6-tetrahydropyrimidinethione-2 well-marked with intraperitoneal administration 10--20 minutes prior to irradiation (1000 r, exposure dose rate--10 r/min). As a whole the tetrahydroderivates are more toxic.
D000818:Animals; D005720:Gamma Rays / Q000009:adverse effects; D007928:Lethal Dose 50; D051379:Mice; D011744:Pyrimidinones / Q000494:pharmacology* / Q000633:toxicity; D011837:Radiation-Protective Agents
D011744:Pyrimidinones; D011837:Radiation-Protective Agents
Padiozashchitiye i toksikologicheskie svoistva nekotorykh proizvodnykh 4-oksigeksa- i 1,2,3,6-tetragidropirimidintiona-2.