Effects of salsolinol, a tetrahydroisoquinolone alkaloid, on multiple schedule performance in rats.
Rats were trained to lever press under a multiple fixed-ratio fixed-interval schedule of food reinforcement. Intracerebroventricular injections of salsolinol (1-methyl-6,7-dihydroxytetrahydroisoquinoline), a condensation product of dopamine and acetaldehyde, caused a dose-related decrease in fixed-ratio responding over a dosage range of 15-120 microgram. In contrast, fixed-interval responding was only reduced at the 120 microgram dose and was increased in two of the animals after injection of 15-30 microgram of salsolinol.
D000470:Alkaloids / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D003216:Conditioning, Operant / Q000187:drug effects*; D007276:Injections, Intraventricular; D007546:Isoquinolines / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051381:Rats; D012055:Reinforcement Schedule
D000470:Alkaloids; D007546:Isoquinolines