title: Photoepicutaneous testing. UV-induced protection against photoxic reactions in normal and vitiliginous skin: a clinical and histological study.
abstract: The effect of erythemic UV irradiation on the phototoxic reactions caused by topical methoxsalen + UVA exposure was studied on normal skin, normal-looking skin of vitiligo patients, and vitiliginous skin. Although only slight histological changes were detectable 9 days after irradiation with 5 MED of erythemic UV, this pre-irradiation did induce protection against photoxic reactions in all skin types. This protection was clinically equal in all skin types; the slight differences were not statistically significant. Histological evaluation, however, showed a most conspicuous protective effect on vitiliginous skin. In all skin types the influence of UV pre-irradiation was confined to epidermal protection; the dermal phototoxic changes were unaffected.
mesh_terms: D006801:Humans; D008730:Methoxsalen / Q000494:pharmacology; D009336:Necrosis; D010787:Photosensitivity Disorders / Q000517:prevention & control; D012867:Skin / Q000473:pathology; D012882:Skin Tests; D014466:Ultraviolet Rays / Q000009:adverse effects; D014820:Vitiligo / Q000473:pathology
chemical_list: D008730:Methoxsalen