Treatment of neuroblastoma in mice with bromoacetylcholine and bromoacetate.
Bromoacetylcholine (30 mg/kg intratumor one to three times per day) and bromoacetate (12 mg/kg intratumor two times per day) inhibited neuroblastoma in A/J mice efficiently and prolonged the lifespan of these animals at least 200%. Since the neuroblastoma-inoculated A/J mice are considered to be comparable to human neuroblastoma, the cytolytic action of bromoacetylcholine and bromoacetate on murine neuroblastoma warrants further studies on patients. The fact that these tumors were cured in adult mice is very important because older children and adults with neuroblastoma have the poorest prognosis.
D000085:Acetates / Q000494:pharmacology / Q000627:therapeutic use*; D000109:Acetylcholine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000818:Animals; D001285:Atropine / Q000627:therapeutic use; D002478:Cells, Cultured; D002800:Cholinesterase Inhibitors; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D009374:Neoplasms, Experimental / Q000188:drug therapy; D009447:Neuroblastoma / Q000188:drug therapy*
D000085:Acetates; D002800:Cholinesterase Inhibitors; D001285:Atropine; D000109:Acetylcholine