[Effect of calcitonin, somatostatin and cimetidine on stress ulcer in rats].
The prophylactic effect of calcitonin, somatostatin and cimetidine on stress ulcer formation in rats was investigated in two stress models: restraint + ketamin (4 h) and hypovolemia (4 h). The basis of the comparative study was a 70% inhibition of acid secretion for 4 h in pyloric ligated animals. This was achieved with 1000 microgram/kg somatostatin s.c., 10 microgram/kg calcitonin s.c., and 2 X 100 mumol/kg cimetidine s.c. In restraint stress and ketamin with calcitonin and cimetidine a significantly lower frequency of gastric lesions was found than with somatostatin. The most potent substance in hypovolemia was calcitonin, with a significant difference in the frequency of mucosal lesions to the groups with cimetidine and somatostatin.
D000818:Animals; D002116:Calcitonin / Q000627:therapeutic use*; D002927:Cimetidine / Q000627:therapeutic use*; D003864:Depression, Chemical; D005750:Gastric Juice / Q000378:metabolism*; D006146:Guanidines / Q000627:therapeutic use*; D008297:Male; D011708:Pylorus / Q000502:physiology; D051381:Rats; D012636:Secretory Rate / Q000187:drug effects; D013004:Somatostatin / Q000627:therapeutic use*; D013276:Stomach Ulcer / Q000209:etiology / Q000517:prevention & control*; D013312:Stress, Physiological / Q000150:complications*
D006146:Guanidines; D013004:Somatostatin; D002927:Cimetidine; D002116:Calcitonin
Wirkung von Calcitonin, Somatostatin und Cimetidine auf das Stressulkus der Ratte.