Antagonism by taurine of morphine induced growth hormone secretion.
The intraperitoneal (IP) or intraventricular (IVT) administration of small amounts of taurine did not modify pentobarbital-induced sleep or pituitary hormone release. However, the drastic increment in plasma GH values induced by morphine administration was completely blocked by the IVT injection of the amino acid. Whether taurine plays a physiological role in the control of GH secretion is highly speculative.
D000818:Animals; D013006:Growth Hormone / Q000378:metabolism*; D008297:Male; D009020:Morphine / Q000037:antagonists & inhibitors*; D010424:Pentobarbital / Q000037:antagonists & inhibitors; D051381:Rats; D012890:Sleep / Q000187:drug effects; D013654:Taurine / Q000494:pharmacology*
D013654:Taurine; D009020:Morphine; D013006:Growth Hormone; D010424:Pentobarbital