[Attempts of sensitizing guinea-pigs with five different derivates of para-substituted benzene (author's transl)].
Skin tests with derivatives of para-substituted benzene were carried out at 4 different concentrations on a total of 160 guinea pigs. Results were evaluated macroscopically and histologically. Each substance was tested on 32 animals. Sensitization was obtained with p-aminodiphenylamine in about 50%, with p-toluylenediamine in about 25%, with 1% and 2% p-phenylenediamine in 62% with 5% p-aminoazotoluene in 37%, whereas no sensitization was observed with p-aminobenzoic acid. Thus, p-aminodiphenylamine, p-toluylenediamine and p-phenylenediamine must be regarded as highly sensitizing agents, whereas p-aminozotoluene and p-aminobenzoic acid seem to be less effective respectively non sensitizing.
D000818:Animals; D001555:Benzene Derivatives / Q000494:pharmacology*; D003877:Dermatitis, Contact / Q000473:pathology; D004342:Drug Hypersensitivity / Q000473:pathology; D006168:Guinea Pigs; D008297:Male; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D012882:Skin Tests
D001555:Benzene Derivatives
Sensibilisierungsversuche an Meerschweinchen mit fünf parasubstituierten Benzolderivaten.