Hemoperfusion with uncoated amberlite XE-336 resin in normal and uremic dogs.
Amberlite XE-336 is a pyrolized polystyrene resin with an adsorptive spectrum similar to activated charcoal. 5 normal (group I) and 5 uremic (group II) dogs had 6 h of hemoperfusion with a 400-gram column of Amberlite XE-336 resin with a blood flow rate of 300 ml/min. In group II during 0, 0.5, 1, 3, and 6 h of hemoperfusion the mean column clearances of creatinine were 273 +/- 10, 224 +/- 7, 177 +/- 8, 125 +/- 30, and 64 +/- 17 ml/min and the serum creatinine concentration decreased from 10.4 +/- 1.3 to 3.2 +/- 0.9 mg/dl. In one of the uremic dogs the column clearance of middle molecules measured at 0, 0,5, 1, 3, and 6 h of hemoperfusion was 273,258,101,109, and 23 ml/min. The side reactions in group I and II hemoperfusion studies included transient hypotension, hypocalcemia, leukopenia and a reduction in platelet count.
D000327:Adsorption; D000818:Animals; D001792:Blood Platelets; D002118:Calcium / Q000097:blood; D002850:Chromatography, Gel; D003404:Creatinine / Q000097:blood; D004285:Dogs; D006464:Hemoperfusion; D007958:Leukocyte Count; D008274:Magnesium / Q000097:blood; D008297:Male; D011137:Polystyrenes; D012116:Resins, Plant; D012964:Sodium / Q000097:blood; D014118:Toxins, Biological / Q000097:blood; D014511:Uremia / Q000097:blood / Q000378:metabolism / Q000628:therapy*
D011137:Polystyrenes; D012116:Resins, Plant; D014118:Toxins, Biological; C016978:Amberlite XE-336; D012964:Sodium; D003404:Creatinine; D008274:Magnesium; D002118:Calcium