Hexosaminidase A in amniotic fluid of Tay-Sachs fetuses.
Hexosaminidase A is present in relatively low concentrations in cell-free amniotic fluids from pregnancies with Tay-Sachs fetuses. This isoenzyme was determined by an immunological procedure, radial immunodiffusion, by which hexosaminidase A can be directly and specifically detected, even in the presence of excess amounts of hexosaminidase B. No hexosaminidase A could be detected by the same procedure in Tay-Sachs fetal tissues, implying that this isoenzyme in the amniotic fluid originates from the mother.
D000653:Amniotic Fluid / Q000201:enzymology*; D005260:Female; D006596:Hexosaminidases / Q000032:analysis*; D006801:Humans; D007527:Isoenzymes / Q000032:analysis; D008064:Lipidoses / Q000175:diagnosis*; D011247:Pregnancy; D011296:Prenatal Diagnosis
D007527:Isoenzymes; D006596:Hexosaminidases