Intrauterine injection of vitamin K before the delivery during anticoagulant therapy of the mother.
The coagulation factors PP% (Factors II+IV), factor IX and factor X were determined in infants born by mothers receiving anticoagulants. The factors were very low when the mothers did not receive vitamin K before the delivery. No significant improvement in the factors was observed after an intravenous or intraamniotic injection of vitamin K two to four days before the delivery. Vitamin K was injected intramuscularly into four foetuses in utero using an ultrasonic multitransducer scanner. Three of these infants had normal coagulation factors at birth. In the fourth case the factor X was normal and factor IX was significantly better than in the infants of the other groups. The injection had no harmful effects to the infants.
D000328:Adult; D000650:Amnion; D000925:Anticoagulants / Q000627:therapeutic use*; D002118:Calcium / Q000032:analysis; D005164:Factor IX / Q000032:analysis; D005170:Factor X / Q000032:analysis; D005260:Female; D005312:Fetal Blood / Q000032:analysis; D006801:Humans; D007231:Infant, Newborn; D007267:Injections; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy*; D011516:Prothrombin / Q000032:analysis; D013923:Thromboembolism / Q000188:drug therapy*; D014599:Uterus; D014812:Vitamin K / Q000008:administration & dosage / Q000627:therapeutic use*
D000925:Anticoagulants; D014812:Vitamin K; D011516:Prothrombin; D005164:Factor IX; D005170:Factor X; D002118:Calcium