title: Synthesis and local anesthetic properties of secondary alkoxyalkylaminoacylanilides.
abstract: Nineteen secondary alkoxyalkylaminoacylanilides were prepared. They were weaker bases and were more hydrophilic than the corresponding analogs lacking the ether function. In 2% solution, these compounds blocked the rat sciatic nerve in vivo after relatively short onset times with good frequency of anesthesia. The duration of block was 0.4--1.5 times that of lidocaine. Their systemic toxicity was low, and their irritation liability in most instances was acceptable.
mesh_terms: D000779:Anesthetics, Local / Q000138:chemical synthesis* / Q000633:toxicity; D000813:Anilides / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D005260:Female; D007928:Lethal Dose 50; D008722:Methods; D051379:Mice; D009407:Nerve Block; D011817:Rabbits; D051381:Rats; D012584:Sciatic Nerve / Q000187:drug effects
chemical_list: D000779:Anesthetics, Local; D000813:Anilides