[Effect of different leukocyte pyrogen fractions on hemopoiesis].
Fractionation of leukocyte pyrogen on a column of Sephadex G-75 made it possible to obtain separately the fraction stimulating the hemopoiesis and the fraction possessing the pyrogenic activity and inhibiting the hemopoiesis. Judging by the elution profile of Sephadex column G-75, substances of high molecular weight produced a stimulating action, and of low molecular weight--pyrogenic and inhibitory action. Possibly pyrogenic and inhibitory activities are connected with different substances. The nature of the inhibitory factor requires further investigation. It may be supposed that it is a substance of chalone type.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D004247:DNA / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006410:Hematopoiesis / Q000187:drug effects*; D007962:Leukocytes; D008970:Molecular Weight; D011749:Pyrogens / Q000302:isolation & purification / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats
D011749:Pyrogens; D004247:DNA
Vliianie razlichnykh fraktsiĭ leĭkotsitarnogo pirogena na gemopoéz.