Profound hypothermia in golden hamsters (Mesocricetus auratus) induced by serotonergic potentiating and noradrenergic inhibiting drugs.
Profound hypothermia (6 degrees C) was induced in cold exposed golden hamsters (Mesocricetus auratus) by a combination of drugs that potentiate brain serotonergic activity (fluoxetine and pargyline) and inhibit noradrenergic activity (alpha-methyl-p-tyrosine). Individual drugs and combinations of 2 were ineffective.
D000818:Animals; D006224:Cricetinae; D005260:Female; D007036:Hypothermia, Induced; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology*; D010293:Pargyline / Q000494:pharmacology*; D010647:Phenyl Ethers / Q000494:pharmacology; D011437:Propylamines / Q000494:pharmacology*
D008781:Methyltyrosines; D010647:Phenyl Ethers; D011437:Propylamines; D010293:Pargyline