Relations between the cortico-papillary osmotic gradient and saline diuresis in normal and acutely hypophysectomized rats.
The renal osmotic cortico-papillary gradient and those of sodium, potassium and urea have been determined in normal and hypophysectomized hydropaenic rats and in normal and hypophysectomized saline-loaded rats, hypophysectomy having been performed 2 h prior to the kidney excisions (acute hypophysectomy). Saline loading was found to depress the renal cortico-papillary gradients in both the normal and hypophysectomized rats, the decrease being more pronounced in the latter. Since the hypophysectomized rats excreted significantly less sodium than normals it is inferred that the depressed cortico-papillary osmotic gradient need not invariably be the decisive factor promoting renal sodium excretion as has generally been accepted.
D000818:Animals; D007016:Hypophysectomy; D007668:Kidney / Q000032:analysis / Q000502:physiology* / Q000503:physiopathology; D007672:Kidney Cortex / Q000032:analysis; D007679:Kidney Medulla / Q000032:analysis; D008297:Male; D009318:Natriuresis / Q000187:drug effects; D009995:Osmosis / Q000187:drug effects; D011188:Potassium / Q000032:analysis; D051381:Rats; D012964:Sodium / Q000032:analysis; D012965:Sodium Chloride / Q000008:administration & dosage; D014508:Urea / Q000032:analysis
D012965:Sodium Chloride; D014508:Urea; D012964:Sodium; D011188:Potassium