title: Measurement of oxygen consumption and locomotor activity in monosodium glutamate-induced obesity.
abstract: Oxygen consumption and locomotor activity were studied in mice developing obesity after neonatal administration of monosodium glutamate (MSG) and in untreated controls. MSG-treated mice became obese in the absence of increased food intake. Locomotor activity was significantly less in MSG-treated mice 2, 10, and 20 wk after weaning. Oxygen consumption expressed in terms of the Lee index was not significantly different at 2 wk after weaning although at 10 and 20 wk it was significantly lower in MSG-treated mice. Plasma thyroxine was not different between MSG-treated and control mice. It is suggested that diminished energy expenditure is the major factor in the etiology of obesity after neonatal administration of MSG.
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D005971:Glutamates / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D009765:Obesity / Q000139:chemically induced* / Q000378:metabolism / Q000503:physiopathology; D010101:Oxygen Consumption / Q000187:drug effects*; D012970:Sodium Glutamate / Q000494:pharmacology*
chemical_list: D005971:Glutamates; D012970:Sodium Glutamate