title: [Distribution and properties of the alkaline phosphatase in the human gastric mucosa in peptic ulcer].
abstract: In duodenal ulcer alkaline phosphatase activity was the highest in mucosa of pyloric region of curvature ventriculi minor and it decreased distinctly in the tissues removed from pylorus. In cases of gastric ulcer, the enzymatic activity was high throughout the curvatura ventriculi minor reaching the maximal value at the ulcerous zone. Alkaline phosphatase from gastric mucosa resembled the enzyme from intestine in its inhibition patterns with 1-phenylalanine and in inactivation properties at 56 degrees within 15 min; but, as distinct from the latter, the enzyme was more stable at 65 degrees within 5 min, maintaining 50% of the initial activity.
mesh_terms: D000469:Alkaline Phosphatase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D004381:Duodenal Ulcer / Q000201:enzymology; D004789:Enzyme Activation; D005753:Gastric Mucosa / Q000201:enzymology*; D006801:Humans; D007413:Intestinal Mucosa / Q000201:enzymology; D010437:Peptic Ulcer / Q000201:enzymology*; D010649:Phenylalanine / Q000494:pharmacology; D013276:Stomach Ulcer / Q000201:enzymology; D013696:Temperature
chemical_list: D010649:Phenylalanine; D000469:Alkaline Phosphatase
vernacular_title: Raspredelenie i nekotorye svoĭstva shchelochnoĭ fosfatazy v slizistoĭ obolochke zheludka cheloveka pri iazvennoĭ bolezni.