Induction of spleen cell growth and DNA polymerase activity by Corynebacterium parvum.
Corynebacterium parvum induces rapid proliferation of spleen cells with concomitant rapid increases in DNA synthesis as measured by [3H]thymidine uptake and increase in DNA polymerase activity. Cell number increased exponentially over 10 days. DNA polymerase activity increased 8-fold after C. parvum stimulation. The rapidity of response indicated a population response to the stimulus, and the data are consistent with a direct stimulation of spleen cell proliferation by C. parvum.
D000818:Animals; D002452:Cell Count; D002455:Cell Division; D004247:DNA / Q000096:biosynthesis; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism*; D005260:Female; D007700:Kinetics; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009929:Organ Size; D011425:Propionibacterium acnes / Q000276:immunology*; D013154:Spleen / Q000033:anatomy & histology / Q000166:cytology* / Q000378:metabolism
D004247:DNA; D004259:DNA-Directed DNA Polymerase