Inhibition of African swine fever (ASF virus replication by phosphonoacetic acid.
Phosphonoacetic acid (PAA) inhibits the multiplication of African swine fever (ASF) virus in VERO cells. The observed inhibition of the in vivo DNA synthesis could be related to the in vitro inhibition of a virus-induced DNA polymerase activity present in cytoplasmic extracts from infected VERO cells.
D000358:African Swine Fever Virus / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D002460:Cell Line; D002474:Cell-Free System; D004261:DNA Replication / Q000187:drug effects; D004279:DNA, Viral / Q000096:biosynthesis; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism; D007497:Iridoviridae / Q000187:drug effects*; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D010746:Phosphonoacetic Acid / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects*
D004279:DNA, Viral; D009943:Organophosphorus Compounds; D004259:DNA-Directed DNA Polymerase; D010746:Phosphonoacetic Acid