Urinary excretion of N-nitrosodiethanolamine administered orally to rats.
N-Nitrosodiethanolamine (NDE1A) was administered by gavage to male rats in single doses of 1000, 500 and 100 mg/kg body wt. More than 70% of a given dose was excreted unchanged in the urine, essentially within the first 24 h after exposure. This high excretion rate might explain the relatively low carcinogenic potential of NDE1A, and also offers a possible method of monitoring exposure to this compound under occupational and/or environmental conditions.
D000284:Administration, Oral; D000818:Animals; D004052:Diethylnitrosamine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000652:urine*; D008297:Male; D009602:Nitrosamines / Q000652:urine*; D051381:Rats; D013997:Time Factors
D009602:Nitrosamines; C014129:N-nitrosodiethanolamine; D004052:Diethylnitrosamine