[Effect of dihydroergotamine, reserpine and anapriline on the pharmacokinetics and metabolism of norsulfazole in rats].
In in vivo experiments with rats anapriline (1 mg/kg) greatly reduced the level of gastrically introduced norsulfazol (200 mg/kg) in the blood, liver, kidneys, stomach, small and large intestine both in healthy rats as well as in those with experimental gastritis provoked by acetylsalicylic acid twice introduced into the stomach. Under the influence of anapriline the acetylization of norsulfazol in the liver would become 4.7 times less intensive. Dihydroergotamin (10 mg/kg) did not influence the absorption, distribution and acetylization of norsulfazol. Reserpine (10 mg/kg) brought down the amount of free norsulfazol in the gastro-intestinal tract and reduced the quantity of acetylized norsulfazol in the blood, stomach, small and large intestines. The acetylization changes in the kidneys were not significant. In the springtime the intensity of the norsulfazol acetylization increases by more than twice. The described results bear witness to the participation of beta-adrenoreceptors in the transport and metabolism of norsulfazol.
D000042:Absorption; D000107:Acetylation; D000818:Animals; D004087:Dihydroergotamine / Q000494:pharmacology*; D005609:Free Radicals; D005756:Gastritis / Q000188:drug therapy; D007700:Kinetics; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D012110:Reserpine / Q000494:pharmacology*; D013432:Sulfathiazoles / Q000378:metabolism* / Q000627:therapeutic use
D005609:Free Radicals; D013432:Sulfathiazoles; D004087:Dihydroergotamine; D012110:Reserpine; D011433:Propranolol
Vliianie digidroérgotamina, rezerpina i anaprilina na farmakokinetiku i metabolizm norsul'fazola u krys.