[Comparison of the effect of ildamen and nonachlazin on the blood supply and activities of the heart].
Instravenous infusion of ildamen (0.8-1 mg/kg) into anesthesized cats caused an increase in coronary blood flow and oxygen consumption by the heart to an approximately equal degree; the resistance of the coronary vessels diminished. The values of cardiac activity (cardiac output, contractions, pulse rate) increased simultaneously with increase of the coronary blood flow. In distinction to ildamen, nonachlasin (6 mg/kg) reduced the arterio-venous difference in oxygen and increased the content of oxyhemoglobin in the draining coronary blood. In anesthesized animals cardiac activity altered in two stages. Since beta-adrenergic blocking agents prevented the increase in coronary blood flow and the intensification of cardiac contractions induced by both drugs it is assumed that their effect is caused through  stimulation of the beta-adrenergic structures. Besides, ildamen and nonachlasin possess the property of inhibiting cardiac activity. The combination of these two opposite effects evidently plays an important role in the realization of the antianginal effect of the substances studied.
D000818:Animals; D001783:Blood Flow Velocity; D002415:Cats; D003326:Coronary Circulation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects; D010099:Oxyfedrine / Q000494:pharmacology*; D010640:Phenothiazines / Q000494:pharmacology*; D010879:Piperazines / Q000494:pharmacology*; D011427:Propiophenones / Q000494:pharmacology*; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology*
D010640:Phenothiazines; D010879:Piperazines; D011427:Propiophenones; D014665:Vasodilator Agents; D010099:Oxyfedrine
Sopostavlenie vliianiia il'damena i nonakhlazina na krovosnabzhenie i deiatel'nost' serdtsa.