[Determination of antibodies against nicotinic acetylcholine receptor: clinico-immunological correlations in 30 patients with myasthenia gravis].
In 30 patients with myasthenia gravis, serum assays were performed for antibodies to human nicotinic acetylcholine receptor. 19 of 20 generalized forms which were symptomatic and 6 of 9 patients in remission at the time of blood sample had detectable amounts of antibodies. The six highest levels were found in benign courses. 2 patients had a five- and twofold drop in antibody level during rapid deterioration. Patients in remission after thymectomy may still have low to moderate levels, while symptomatic patients occasionally have no detectable antibody.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000941:Antigens; D001323:Autoantibodies / Q000032:analysis*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000276:immunology; D009157:Myasthenia Gravis / Q000276:immunology*; D011950:Receptors, Cholinergic; D012075:Remission, Spontaneous; D013934:Thymectomy; D013945:Thymoma / Q000150:complications
D000941:Antigens; D001323:Autoantibodies; D011950:Receptors, Cholinergic
Dosage des anticorps dirigés contre le récepteur nicotinique de l'acétylcholine: corrélations clinico-immunologiques chez 30 myasthéniques.