Facilitation of lordosis behavior by clonidine in female guinea pigs.
Lordosis behavior was induced in previously unreceptive, ovariectomized estrogen-primed female guinea pigs by administration of the noradrenergic agonist clonidine. Clonidine also enhanced lordosis responding in females that were weakly receptive after estrogen priming. Unlike progesterone, the lordosis-facilitating effect of clonidine was not accompanied by a subsequent refractory period. Clonidine had a weak lordosis facilitatory effect when administered during the decline in receptivity to estrogen plus progesterone-primed animals and failed to induce lordosis when administered during the refractory period.
D000818:Animals; D002369:Castration; D003000:Clonidine / Q000494:pharmacology*; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D006168:Guinea Pigs; D011374:Progesterone / Q000494:pharmacology; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D013268:Stimulation, Chemical; D013997:Time Factors
D011374:Progesterone; D004958:Estradiol; D003000:Clonidine