Demonstration of the reversibility of spermatozoa suppression by testosterone oenanthate.
Long-term treatment with testosterone oenanthate in seven healthy young men was conducted with the aim of inducing reversible inhibition of spermatogenesis. During the observation period following discontinuation of the therapy spermatogenesis showed a gradual recovery. In three cases, however, the sperm counts did not reach pre-treatment levels. The subjects were re-examined 3 years after the start of the study, i.e. 2.5 years after the last injection of testosterone oenanthate. This examination confirmed that the testosterone treatment had had no recognizable negative influence on testicular function--on the contrary, in three cases analysis of the seminal fluid yielded higher sperm counts than previously.
D002452:Cell Count; D006801:Humans; D008297:Male; D013081:Sperm Motility / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects*; D013739:Testosterone / Q000494:pharmacology*
D013739:Testosterone