Hormone-stimulated heme synthesis by isolated mitochondria.
Erythropoietin (Ep), insulin, and prostaglandins E1 and A1 (PGE1, PGA1) enhanced heme synthesis by mitochondria isolated from embryonic and adult mouse liver cells. The combination of Ep with PGE1 had an antagonistic effect, while that of Ep with PGA1 gave an additive result. The capability of isolated human platelet mitochondria to synthesize heme was also shown. This activity was stimulated by Ep.
D000375:Aging; D000818:Animals; D002074:Butanones / Q000378:metabolism; D004921:Erythropoietin / Q000494:pharmacology*; D006418:Heme / Q000096:biosynthesis*; D007328:Insulin / Q000494:pharmacology*; D051379:Mice; D008930:Mitochondria, Liver / Q000648:ultrastructure; D011454:Prostaglandins A / Q000494:pharmacology; D011458:Prostaglandins E / Q000494:pharmacology
D002074:Butanones; D007328:Insulin; D011454:Prostaglandins A; D011458:Prostaglandins E; D004921:Erythropoietin; D006418:Heme