title: Polypoid carcinoma of the esophagus. A unifying term for "carcinosarcoma" and "pseudosarcoma".
abstract: Polypoid carcinomas with spindle-cell sarcomatous features have been designated either as carcinosarcoma or pseudosarcoma. The distinction between these two tumors has depended on the presence of "intermingling" of the carcinomatous and sarcomatous components in so-called carcinosarcoma. But unlike the carcinosarcoma, the sarcomatous component in pseudosarcoma has been considered benign. A polypoid tumor of the esophagus in a 57-year-old male was predominantly composed of spindle cell, sarcomatous cells. The presence of adjacent intraepithelial epidermoid carcinoma with transitional and ultrastructural features confirmed the epithelial origin of this tumor. Because of the absence of "intermingling," the primary tumor was considered to be a pseudosarcoma. However, our postmortem examination showed metastases composed of both carcinomatous and sarcomatous features. A review of the literature on carcinosarcomas and pseudosarcomas shows that only one case of pseudosarcoma reported by Hughes and Cruickshank showed a similar situation and indicates that the sarcomatous component in pseudosarcomas has the same metastatic potentiality as has been reported in carcinosarcomas. We conclude from these studies a basic similarity of the carcinosarcoma and pseudosarcoma. The term polypoid carcinoma is proposed for both these lesions.
mesh_terms: D001983:Bronchial Fistula / Q000150:complications; D001984:Bronchial Neoplasms / Q000150:complications; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D002296:Carcinosarcoma / Q000473:pathology*; D004937:Esophageal Fistula / Q000150:complications; D004938:Esophageal Neoplasms / Q000150:complications / Q000473:pathology* / Q000648:ultrastructure; D005350:Fibroma / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009626:Terminology as Topic