Indomethacin esters acting as anti-inflammatory and immunosuppressive drugs.
Administration of indomethacin and ten different indomethacin derivatives led to a variable depression in the mice immume response to sheep red blood cells (SRBC) as shown either by direct hemolytic-plaque assay or hemagglutination tests. Compounds with a lower toxicity than indomethacin and predominant immunosuppressive or anti-inflammatory activity were obtained. According to the variations in the primary immune response and to their variable anti-inflammatory actions, the structure-activity relationships are documentted and some possible explanations, relative to their immunodepressive effect, are discussed.
D000818:Animals; D000893:Anti-Inflammatory Agents; D007114:Immunization; D007166:Immunosuppressive Agents; D007213:Indomethacin / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D051381:Rats; D012756:Sheep / Q000276:immunology; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D007213:Indomethacin