The requirement for the Fc portion of antibody in antigen-antibody complex-mediated suppression.
The role of the Fc portion of antibody in immune complex-induced suppression was studied in vivo and in vitro. BSA pheasant anti-BSA complexes, formed in antigen excess (Ag1Ab1), were found to suppress both responses to BSA and SRBC. When complexes were formed with F(ab')2 fragments of pheasant anti-BSA, no suppression was observed, indicating that the Fc piece was indeed essential for the induction of Ag-Ab complex-mediated suppression.
D000818:Animals; D000906:Antibodies; D000936:Antigen-Antibody Complex; D001717:Birds; D002645:Chickens; D007141:Immunoglobulin Fc Fragments; D007165:Immunosuppression Therapy; D008297:Male; D012710:Serum Albumin, Bovine / Q000276:immunology
D000906:Antibodies; D000936:Antigen-Antibody Complex; D007141:Immunoglobulin Fc Fragments; D012710:Serum Albumin, Bovine