Naloxone does not antagonize general anesthesia in the rat.
The administration of naloxone 2, 10, 50, or 250 mg/kg intravenously did not alter halothane requirement (MAC) in Sprague-Dawley rats (12 per group). Two rats convulsed when given 50 mg/kg while anesthetized with halothane. In a separate group of awake rats, seven of nine animals convulsed when given naloxone, 100 mg/kg. It is concluded that any effect of naloxone on anesthetic requirement must be small (not significant in our study), and that if an effect exists it is the result of a nonspecific analeptic action of naloxone rather than a specific action at opiate receptors.
D000769:Anesthesia, Inhalation; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004745:Enkephalins / Q000378:metabolism; D006221:Halothane / Q000008:administration & dosage / Q000009:adverse effects / Q000037:antagonists & inhibitors*; D009270:Naloxone / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D051381:Rats; D012640:Seizures / Q000139:chemically induced; D013147:Spirometry
D004745:Enkephalins; D009270:Naloxone; D006221:Halothane