Effect of peptichemio upon localization of injected radiolabelled lymphocytes in the lymphatic organs of antigen-stimulated mice.
Increased localization (trapping) of lymphocytes occurs in lymphoid organs following antigenic challenge. The effect of peptichemio (PTC) upon lymphocyte trapping in lymph nodes and spleen was investigated: the results demonstrate that the drug diminishes trapping in lymphatic organs. The depression of lymphocyte trapping may provide at least one mechanism whereby PTC achieves it immunosuppressive effects.
D000818:Animals; D005260:Female; D007165:Immunosuppression Therapy; D008198:Lymph Nodes / Q000187:drug effects*; D008214:Lymphocytes / Q000187:drug effects*; D051379:Mice; D009588:Nitrogen Mustard Compounds / Q000494:pharmacology*; D010440:Peptichemio / Q000494:pharmacology*; D013154:Spleen / Q000187:drug effects*
D009588:Nitrogen Mustard Compounds; D010440:Peptichemio