[Gas chromatographic determination of diethylcarbamazine (Hetrazan) in serum of laboratory rodents (author's transl)].
After chloroform extraction in an alkaline solution, diethylcarbamazine (DEC) is measured in the presence of dipropylacetamid (internal standard), treated in the same manner, by a gas chromatographic procedure using a nitrogen detector in a 10% BDS column. Results can be easily reproduced for analysis of DEC in sera up to levels of 10 mg/1 and sensibility allows determination of approximately 0.5 mg/l levels on 50-microliter samples of serum. This method is suitable for pharmacokinetic studies.
D000818:Animals; D002849:Chromatography, Gas; D006224:Cricetinae; D004049:Diethylcarbamazine / Q000097:blood*; D004195:Disease Models, Animal; D005368:Filariasis; D051381:Rats; D012377:Rodentia
D004049:Diethylcarbamazine
Méthode de dosage par chromatographie en phase gazeuse de la diéthylcarbamazine (Hétrazan) dans le serum de rongeurs de laboratoire.