[New aspects of the effect of isoniazid on transaminase activity in tuberculosis].
New evidence is obtained for inhibitory effect of isoniazid on activity of transaminases in prolonged application of the drug. Increase in the isoniazid inhibitory effect on alanine aminotransferase activity was shown to correlate with elevated concentration of Cu2+ in blood serum arising in experimental tuberculosis. Cu2+ and Co2+ caused the increase in the inhibitory effect of isoniazid due to their incorporation into structure of the preparation. The microelements, combined with pyridoxine, inhibited alanine aminotransferase and vice versa activated aspartate aminotransferase.
D000410:Alanine Transaminase / Q000378:metabolism*; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism*; D003035:Cobalt / Q000627:therapeutic use; D003300:Copper / Q000378:metabolism / Q000627:therapeutic use; D007538:Isoniazid / Q000627:therapeutic use*; D008099:Liver / Q000378:metabolism; D011736:Pyridoxine / Q000378:metabolism / Q000627:therapeutic use; D011817:Rabbits; D013831:Thiamine / Q000627:therapeutic use; D013997:Time Factors; D014376:Tuberculosis / Q000188:drug therapy* / Q000378:metabolism
D003035:Cobalt; D003300:Copper; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D011736:Pyridoxine; D007538:Isoniazid; D013831:Thiamine
Nekotorye novye aspekty deĭstviia izoniazida na aktivnost' transaminaz pri tuberkuleze.