Amiloride-induced stimulation of HCO-3 reabsorption in turtle bladder.
Amiloride in the mucosal fluid (at concentrations of 5 . 10(-6) M to 10(-4) M) reversibly stimulates the HCO-3-dependent moiety of the short-circuiting current (Isc) in ouabain-treated turtle bladders bathed by Na-free Ringer solutions with or without Cl-. This effect is uniquely different from the known inhibitory effect of this agent on Na+ transport. Thus, any comprehensive hypothesis on the action of amiloride over a wide dosage-response range should take into account its effect on HCO-3 transport.
D000584:Amiloride / Q000494:pharmacology*; D000818:Animals; D001639:Bicarbonates / Q000378:metabolism*; D001693:Biological Transport, Active / Q000187:drug effects; D002712:Chlorides / Q000378:metabolism; D004553:Electric Conductivity; D066298:In Vitro Techniques; D010042:Ouabain / Q000494:pharmacology; D011719:Pyrazines / Q000494:pharmacology*; D012964:Sodium / Q000494:pharmacology; D014426:Turtles; D001743:Urinary Bladder / Q000378:metabolism*
D001639:Bicarbonates; D002712:Chlorides; D011719:Pyrazines; D010042:Ouabain; D000584:Amiloride; D012964:Sodium