title: 3' deoxycytidine, like hydroxyurea, inhibits DNA synthesis without preventing the initiation of the cell cycle.
abstract: 3' Deoxycytidine, the cytidine analogue of cordycepin and selective inhibitor of pre-ribosomal RNA in HeLa cells, has been found to be a reversible inhibitor of DNA replication in RNA accumulation. Like other inhibitors of DNA replication such as hydroxyurea, it does not prevent serum-stimulated quiescent 3T3 cells from undergoing the random transition which is rate-limiting for entry into S phase.
mesh_terms: D002453:Cell Cycle / Q000187:drug effects*; D002460:Cell Line; D004247:DNA / Q000096:biosynthesis*; D003841:Deoxycytidine / Q000494:pharmacology*; D006918:Hydroxyurea / Q000494:pharmacology*; D012313:RNA / Q000096:biosynthesis; D013936:Thymidine / Q000378:metabolism
chemical_list: D003841:Deoxycytidine; D012313:RNA; D004247:DNA; D013936:Thymidine; D006918:Hydroxyurea