Are the high mobility group non-histone chromosomal proteins associated with 'active' chromatin?
When 10--20% of the DNA in thymus and liver nuclei is rendered acid-soluble by DNAase I digestion, under conditions which may be expected to specifically degrade away most of the transcribed sequences, very little of the high-mobility-group non-histone proteins are released from the nuclei. Therefore, high-mobility-group proteins are probably not specifically associated with this portion of the genome.
D000818:Animals; D002843:Chromatin / Q000378:metabolism* / Q000648:ultrastructure; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism*; D003851:Deoxyribonucleases / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D011485:Protein Binding; D011817:Rabbits; D051381:Rats; D013950:Thymus Gland / Q000378:metabolism; D014158:Transcription, Genetic
D002843:Chromatin; D002868:Chromosomal Proteins, Non-Histone; D003851:Deoxyribonucleases