[Protein evolution rate and immunoglobulin induction].
The capacity of proteins to induce the synthesis of specific immunoglobulins was shown to be correlated with their evolution rate. This correlation can be understood in terms of the clonal-selectional theory. The characteristic correlation parameter is the number of differences in the amino acid sequences between the immunogenic protein and the homological protein of the immunized animal. The above correlation was traced most clearly for the evolutionary conservative proteins.
D000199:Actins / Q000276:immunology; D000595:Amino Acid Sequence; D000818:Animals; D005075:Biological Evolution; D006168:Guinea Pigs / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins / Q000096:biosynthesis*; D007328:Insulin / Q000276:immunology; D011506:Proteins / Q000276:immunology*; D011817:Rabbits / Q000276:immunology; D013045:Species Specificity
D000199:Actins; D007136:Immunoglobulins; D007328:Insulin; D011506:Proteins
Skorost' évoliutsii belkov i induktsiia immunoglobulinov.