Subcorneal pustular dermatosis (Sneddon-Wilkinson disease)--therapeutic problems.
A patient with subcorneal pustular dermatosis with a fatal outcome is presented. Treatment with corticosteroids, vitamin E, dapsone, sulphapyridine and levamisole was ineffective. Only systemic treatment with retinoic acid and a new aromatic retinoic acid derivative (Ro 10-9359) produced a satisfactory clinical response, but a complete remission was not obtained.
D000368:Aged; D006801:Humans; D008297:Male; D012872:Skin Diseases, Vesiculobullous / Q000188:drug therapy*; D014212:Tretinoin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014801:Vitamin A / Q000031:analogs & derivatives*
D014801:Vitamin A; D014212:Tretinoin