Aminoglycoside antibiotics. XII. Effect of N-alkylation in kanamycin antibiotics.
Four N-ethyl derivatives of kanamycin A and five N-ethyl derivatives of kanamycin B were synthesized. The antimicrobial activity of N-ethyl kanamycin derivatives was determined against aminoglycoside-sensitive and resistant organisms. The structure-activity relationship of these compounds is discussed with reference to the activity of N-acyl kanamycin derivatives.
D000478:Alkylation; D001419:Bacteria / Q000187:drug effects; D004352:Drug Resistance, Microbial; D007612:Kanamycin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D013329:Structure-Activity Relationship
D007612:Kanamycin