title: Nerve fibre refractory period in patients treated with rubidium and lithium.
abstract: Nerve fibre refractory period distributions have been measured on the median nerves of six manic-depressive patients controlled with lithium carbonate, three chronic patients (two manic-depressives and one catatonic schizophrenic) controlled with rubidium chloride, and eight normal volunteers. Rubidium prolonged the refractory periods of all nerve fibres while lithium increased only the longer refractory periods.
mesh_terms: D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000188:drug therapy / Q000503:physiopathology; D002648:Child; D005260:Female; D006801:Humans; D008094:Lithium / Q000627:therapeutic use*; D008297:Male; D008475:Median Nerve / Q000187:drug effects* / Q000503:physiopathology; D008875:Middle Aged; D009412:Nerve Fibers / Q000187:drug effects* / Q000502:physiology; D009431:Neural Conduction / Q000187:drug effects*; D012032:Refractory Period, Electrophysiological / Q000187:drug effects*; D012413:Rubidium / Q000627:therapeutic use*; D012560:Schizophrenia, Catatonic / Q000188:drug therapy / Q000503:physiopathology
chemical_list: D008094:Lithium; D012413:Rubidium