Tocopherol and local X-ray irradiation of two transplantable rat tumours.
The influence of tocopherol in an intramuscular dose of 5 mg/100 g body wt. on the effect of local X-ray irradiation of 2 intramuscularly transplanted tumours in the rat was studied. A significantly enhanced effect of irradiation by tocopherol was found, in contrast to the tumour radioprotecting effect with large doses of tocopherol earlier described in literature.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D007273:Injections, Intramuscular; D008114:Liver Neoplasms, Experimental / Q000378:metabolism / Q000628:therapy*; D011838:Radiation-Sensitizing Agents; D051381:Rats; D011919:Rats, Inbred Strains; D012513:Sarcoma, Experimental / Q000378:metabolism / Q000628:therapy*; D014810:Vitamin E / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*
D011838:Radiation-Sensitizing Agents; D014810:Vitamin E