Photic EEG-driving responses in thalamotomized and medicated cases of Parkinson's disease.
EEG-driving responses to visual stimulation were studied using EEG Interval Spectrum Analysis (EISA) before and after stereotaxic thalamotomy and Nacom (L--Carbidopa and Levodopa) treatment of 67 Parkinson patients. Five types of photic-driving responses were distinguished in the EISA results: (1) all-band response, (2) Beta-dominant, (3) Alpha-Beta-dominant, (4) Alpha-Theta-dominant, (5) non-response. Twenty patients received a daily dose of 750--1000 mg of Nacom orally, and 47 patients 1000--1500 mg for a period of 3 to 4 weeks. In most cases the medication produced no change in photic-driving and EEG patterns. The photic-driving response showed no significant correlation with clinical signs and background EEG. Unilateral thalamotomy was performed in ten Parkinson patients. In two of these patients the EEG-driving response diminished in the first post-operative week for low frequency stimuli but increased after the second week.
D000328:Adult; D000368:Aged; D000513:Alpha Rhythm; D001611:Beta Rhythm; D002230:Carbidopa / Q000627:therapeutic use; D004569:Electroencephalography / Q000379:methods*; D005260:Female; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy / Q000503:physiopathology* / Q000601:surgery; D010775:Photic Stimulation; D013057:Spectrum Analysis / Q000379:methods; D013788:Thalamus / Q000601:surgery; D013826:Theta Rhythm
D007980:Levodopa; D002230:Carbidopa