Alterations in levels of vascular histamine in the DOCA-hypertensive rat.
1. Histamine was detected in the abdominal aorta and the femoral arteries of normotensive and also DOCA-hypertensive rats. 2. Levels of total histamine (mast cell and non-mast cell histamine) were significantly reduced in both abdominal aorta and the femoral artery of the DOCA-hypertensive rats, relative to the normotensive controls. 3. It is suggested that the diminished level of vascular histamine may be related to the development and/or maintenance of the hypertensive state and is also related to the  reduced magnitude of active reflex vasodilatation.
D000818:Animals; D001808:Blood Vessels / Q000378:metabolism*; D003900:Desoxycorticosterone / Q000494:pharmacology; D006632:Histamine / Q000378:metabolism*; D006973:Hypertension / Q000139:chemically induced / Q000378:metabolism*; D008297:Male; D051381:Rats; D013997:Time Factors
D003900:Desoxycorticosterone; D006632:Histamine