GLC--mass spectrometry of several important anticancer drugs I: pertrimethylsilylation and O-methoxime formation.
Procedures are reported for the formation of pertrimethylsilyl and pertrimethylsilyl methoxime derivatives of the aglycones of doxorubicin, daunorubicin, carminomycin, chromomycin A3, and mithramycin. The mass spectra are consistent with the formation of these derivatives. Fragmentation patterns highly specific for these derivatives are proposed, and the potential application for the identification of metabolites of these compounds is discussed.
D000903:Antibiotics, Antineoplastic / Q000032:analysis*; D002849:Chromatography, Gas; D013058:Mass Spectrometry; D008722:Methods; D010091:Oximes / Q000138:chemical synthesis; D014297:Trimethylsilyl Compounds
D000903:Antibiotics, Antineoplastic; D010091:Oximes; D014297:Trimethylsilyl Compounds