Hemodynamic parameters and blood gas analyses in the normal and the cirrhotic rat.
Thioacetamide-fed rats developed cirrhosis with portal hypertension (P portal=23.0 +/- 5.2 cm H2O, controls: 14.4 +/- 1.0 cm H2O). The PO2 of liver tissue was markedly reduced in cirrhosis (PO2=7.6 +/- 3.4 torr, controls 22.3 +/- 5.8 torr), and the aortal pH was significantly lower as well. No correlation was found between portal hypertension, development of large--nodular cirrhosis, and ascites.
D000818:Animals; D001201:Ascites / Q000209:etiology; D006975:Hypertension, Portal / Q000139:chemically induced; D008099:Liver / Q000378:metabolism; D008103:Liver Cirrhosis / Q000097:blood* / Q000139:chemically induced; D010101:Oxygen Consumption; D010313:Partial Pressure; D051381:Rats; D013853:Thioacetamide
D013853:Thioacetamide