Effect of self-determined intravenous infusion of hypertonic NaCl on Na appetite of sheep.
The time delay that occurs between a rapid, systemically produced change in Na balance and a change of voluntary Na intake was examined in Na-deficient sheep with a parotid fistula. They were trained to bar press in order to replace a daily Na deficit of 300--500 mmol. During basal conditions on different days, each delivery to a drinking cup consisted of either a small or a large amount of NaHCO3 solution. In the experimental situation, the small amount of NaHCO3 was delivered to the cup, but total Na delivered was made to equal that of the large amount by automatic concurrent infusion of hypertonic NaCl intravenously with each delivery to the cup. As a control, the concurrent intravenous infusion was .15 M NaCl, which had little influence on Na balance. A significant difference in the cumulative number of deliveries between the hypertonic and isotonic NaCl infusion conditions occurred by 10--20 min. It is concluded that systemic injections of hypertonic NaCl are effective within 10 to 20 min in reducing the sodium appetite of Na-depleted animals.
D000818:Animals; D003216:Conditioning, Operant; D004326:Drinking / Q000187:drug effects*; D005260:Female; D006982:Hypertonic Solutions; D007263:Infusions, Parenteral; D007552:Isotonic Solutions; D008297:Male; D009994:Osmolar Concentration; D012527:Satiation; D012756:Sheep; D012964:Sodium / Q000172:deficiency*; D012965:Sodium Chloride / Q000008:administration & dosage / Q000494:pharmacology*
D006982:Hypertonic Solutions; D007552:Isotonic Solutions; D012965:Sodium Chloride; D012964:Sodium