Mobilization of ascites in cirrhotic dogs following furosemide or mannitol diuresis.
Mobilization of ascites was studied in 20 anesthetized dogs with experimental cirrhosis following a mannitol- or furosemide-induced diuresis. Observations were made at 2 h following the drug, at which time the diuresis was invariably completed, and repeated at 4 h following a 2-h recovery period, during which the ureters were clamped to prevent further urinary losses. In the furosemide group the mean urinary loss was 459 +/- 6 ml and was accompanied by a decline in central venous pressure and hemoconcentration. At 2 h plasma volume had declined by 14% from control values, but at 4 h plasma replenishment was 99% complete. At this time ascites volume had decreased by 467 ml, acting as the major source for vascular replenishment. In the mannitol group, the average urinary loss was 190 +/- 10 ml and was accompanied by maintenance of venous pressure, lack of hemoconcentration, and hyponatremia. At 2 h plasma volume had expanded from control values by 22%, but at 4 h vascular replenishment was only 78% complete. The average ascites volume had decreased by only 55% of the diuretic loss, and was mobilized by a complex sequence of events involving movement of intracellular water.
D000818:Animals; D001201:Ascites / Q000503:physiopathology*; D002496:Central Venous Pressure; D004128:Dimethylnitrosamine / Q000009:adverse effects; D004231:Diuresis / Q000187:drug effects*; D004285:Dogs; D005110:Extracellular Space / Q000502:physiology; D005260:Female; D005665:Furosemide / Q000627:therapeutic use*; D007668:Kidney / Q000503:physiopathology; D008103:Liver Cirrhosis / Q000139:chemically induced; D008297:Male; D008353:Mannitol / Q000627:therapeutic use*; D010953:Plasma Volume; D013997:Time Factors
D008353:Mannitol; D005665:Furosemide; D004128:Dimethylnitrosamine