Antigenicity of low concentrated HDCS vaccine with and without adjuvant as compared to the standard fluid formulation.
It can be shown that 0.1% aluminum hydroxide is able to compensate a 90% difference in antigen content of a human diploid cell strain rabies vaccine in man. This conclusion, however, is drawn only from the formation of neutralizing antibodies (kinetics and antibody concentration). Further experiments should be performed to compare also the protective capacity of HDCS vaccines varying in antigen content and adjuvant. A sole reduction of viral antigen is reflected by a corresponding reduction in antibody formation provided the different doses fall within the logarithmic part of the dose-response curve.
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000328:Adult; D000536:Aluminum Hydroxide / Q000494:pharmacology; D000914:Antibodies, Viral / Q000032:analysis; D000917:Antibody Formation / Q000187:drug effects; D000956:Antigens, Viral / Q000032:analysis; D046508:Culture Techniques; D005260:Female; D006801:Humans; D007115:Immunization Schedule; D008297:Male; D011819:Rabies Vaccines / Q000008:administration & dosage / Q000276:immunology*
D000276:Adjuvants, Immunologic; D000914:Antibodies, Viral; D000956:Antigens, Viral; D011819:Rabies Vaccines; D000536:Aluminum Hydroxide