[Effect of prostaglandins E1 and E2 on the internal carotid artery].
Experiments were conducted on the dog internal carotid artery (with circulatory isolation); the following peculiarities of the effects of the prostaglandins (PG) under study were revealed: PG-E1 caused either a constrictory or a dilatory effect, and PG-E1--a constrictory effect only; in the former case the artery became accustomed with repetition of the action, and in the latter case it did not become accustomed. The duration of the PG-E2 effects, particularly of relaxation, was much greater than of the serotonin effects; residual contraction of the vascular smooth muscles was frequent; PG-E1 and PG-E2 intensified the effects of serotonin, and, partially, of noradrenaline.
D000818:Animals; D002339:Carotid Arteries / Q000187:drug effects*; D002343:Carotid Artery, Internal; D004285:Dogs; D004347:Drug Interactions; D005260:Female; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D011458:Prostaglandins E / Q000494:pharmacology*; D011459:Prostaglandins E, Synthetic / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology
D011458:Prostaglandins E; D011459:Prostaglandins E, Synthetic; D012701:Serotonin; D009638:Norepinephrine
Deĭstvie prostaglandinov E1 i E2 na vnutrenniuiu sonnuiu arteriiu.