Immunogenicity of UV-inactivated measles virus.
By means of the antigen extinction limit test it was shown that a triple dose vaccination of guinea pigs with UV-inactivated measles virus gave better results, than a single dose vaccination which was proved by the very low immunogenicity index. For both vaccination schemes (single and triple) the immune response was only slightly influenced by a change of dose from 10(5) to 10(6) HadU50/ml or by the addition of aluminum adjuvant. In the antigen extinction limit test the antibody levels were determined by two methods (HIT and NT) the results of which were statistically equivalent. The UV-inactivated measles virus was also found to induce hemolysis-inhibiting antibodies.
D000276:Adjuvants, Immunologic / Q000276:immunology; D000536:Aluminum Hydroxide / Q000276:immunology; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D004306:Dose-Response Relationship, Immunologic; D006168:Guinea Pigs; D006385:Hemagglutination Inhibition Tests; D008458:Measles Vaccine / Q000008:administration & dosage; D008459:Measles virus / Q000276:immunology* / Q000528:radiation effects; D009500:Neutralization Tests; D014466:Ultraviolet Rays; D014611:Vaccination
D000276:Adjuvants, Immunologic; D000914:Antibodies, Viral; D008458:Measles Vaccine; D000536:Aluminum Hydroxide