[Structuro-functional coniophage transformation as a response to fibrogenic dust and the possibility of its medicinal correction].
Electron microscopic and cytochemical studies indicate that structural and functional changes in coniophage occur under the influence of fibrogenous dust. These changes consiste in fragmentation of single phagolysosomes containing dust particles with the release of the contents into the cytoplasm, disorders in the structure of mitochondria, granular endoplasmic reticulum, and plate apparatus. These changes lead to a decline in the bioenergetics and biosynthetic function of coniophage. At a late stage, a damage of phagolysosomal apparatus as a whole causes autolysis of the cell. A principal possibility of directed effect on the membrane structures of coniophage for the purpose of influencing the initial mechanisms of silicosis development is demonstrated.
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D008058:Dihydrolipoamide Dehydrogenase / Q000378:metabolism; D004391:Dust; D006651:Histocytochemistry; D066298:In Vitro Techniques; D008168:Lung / Q000166:cytology*; D008264:Macrophages / Q000187:drug effects / Q000201:enzymology / Q000648:ultrastructure*; D008854:Microscopy, Electron; D010537:Peritoneum / Q000166:cytology; D010587:Phagocytosis; D011144:Polyvinylpyridine N-Oxide / Q000494:pharmacology; D011791:Quartz; D051381:Rats; D012829:Silicosis / Q000209:etiology*; D013385:Succinate Dehydrogenase / Q000378:metabolism; D013997:Time Factors
D004391:Dust; D011791:Quartz; D011144:Polyvinylpyridine N-Oxide; D013385:Succinate Dehydrogenase; D008058:Dihydrolipoamide Dehydrogenase; D000135:Acid Phosphatase
Strukturno-funktsional'naia perestroika koniofaga pri vozdeĭstvii fibrogennoĭ pyli i vozomozhnosti ee medikamentoznoĭ korrektsii.