Effects of quipazine on behavior under a multiple schedule of reinforcement.
The effects of three doses of quipazine (1.0, 5.0 and 10.0 mg/kg) on the performance of rats under a multiple fixed-ratio 15 fixed-interval 60-sec schedule of food reinforcement were examined. In the absence of drug, response rates under the fixed-ratio component were much higher than response rates under the fixed-interval component. Rates under the fixed-ratio component were decreased by quipazine in dose-dependent fashion, while response rates under the fixed-interval component were increased by the lowest dose and decreased by the two higher doses of the drug.
D000818:Animals; D003216:Conditioning, Operant / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008297:Male; D011804:Quinolines / Q000494:pharmacology*; D011814:Quipazine / Q000494:pharmacology*; D051381:Rats; D012055:Reinforcement Schedule
D011804:Quinolines; D011814:Quipazine