title: Effects of abomasal supplements of methionine on the wool follicles and skin of wheat-fed sheep.
abstract: In wheat-fed sheep, supplemented abomasally with 1.5-6.0 g methionine per day, poor formation and improper keratinization of the wool fibres were evident 4 days after the start of the methionine supplementation. This led to kinking of the fibres. Subsequently severe distortion of the fibres, accompanied by gross thickening of the outer root sheaths, occurred in the distal (upper) halves of most follicles. Within this thickened region partial degradation of the distorted fibres occurred before emergence from the skin surface, causing a marked reduction in the tensile strength of the wool. It is postulated that kinking of the fibres stimulated the accumulation of outer root sheath cells, which led to hyperactivity of the process that normally degrades the inner root sheath, so that the poorly keratinized fibres were also partly degraded. Thickening of the epidermis and cellular infiltration of the upper dermis sometimes occurred during the infusions of methionine, whereas there were negligible effects on the sebaceous and sweat glands. Disappearance of the excess accumulation of outer root sheath cells after cessation of the methionine supplementation occurred gradually following improvement in keratinization and elimination of kinking of the fibres.
mesh_terms: D000018:Abomasum; D000818:Animals; D004032:Diet; D008297:Male; D008715:Methionine / Q000008:administration & dosage / Q000494:pharmacology*; D012756:Sheep / Q000033:anatomy & histology*; D012867:Skin / Q000033:anatomy & histology / Q000187:drug effects*; D014908:Triticum; D014935:Wool / Q000033:anatomy & histology / Q000187:drug effects*
chemical_list: D008715:Methionine