title: Mechanism for interference of hydrochlorothiazide with the Kober reaction for determination of urinary estriol in pregnancy.
abstract: Investigation of the mechanism of the lowering effect of hydrochlorothiazide, which was administered orally, in the determination of estriol from the pregnancy urine has been carried out. The isolation and determination of the structure of a copolymer formed from estriol and formaldehyde have suggested the mechanism by which, during the acid hydrolysis process of the glucuronide conjugate of estriol, some copolymers of estriol and formaldehyde generated from hydrochlorothiazide, were formed, thus lowering the observed values of the estriol contents in the urine.
mesh_terms: D003124:Colorimetry / Q000379:methods; D003864:Depression, Chemical; D004347:Drug Interactions; D004964:Estriol / Q000652:urine*; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000494:pharmacology*; D006912:Hydroxyquinolines; D013058:Mass Spectrometry; D011108:Polymers; D011247:Pregnancy
chemical_list: D006912:Hydroxyquinolines; D011108:Polymers; D006852:Hydrochlorothiazide; D004964:Estriol