Lucio's phenomenon and diffuse nonnodular lepromatous leprosy.
The records of ten patients with Lucio's phenomenon showed clinical and histopathological changes similar to those described by others. Lucio's phenomenon is a syndrome distinct from erythema nodosum leprosum as indicated by an absence of fever, leukocytosis and tenderness, a failure to respond to thalidomide, and a restriction to patients with diffuse nonnodular lepromatous leprosy. Lymphopenia associated with splenomegaly in three patients and glomerulonephritis in one patient were unexpected findings of unknown relevance.
D000328:Adult; D003622:Dapsone / Q000009:adverse effects / Q000627:therapeutic use; D004893:Erythema Nodosum / Q000139:chemically induced; D005260:Female; D006801:Humans; D007511:Ischemia; D007918:Leprosy / Q000150:complications / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D008231:Lymphopenia / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D012189:Retrospective Studies; D012867:Skin / Q000098:blood supply; D013792:Thalidomide / Q000627:therapeutic use
D013792:Thalidomide; D003622:Dapsone