Effects of folic acid on phenytoin kinetics in healthy subjects.
Phenytoin (DPH) disposition was studied in normal subjects before and after treatment with folic acid for 14 days. Our results suggest that folic acid lowers (DPH) serum levels without significantly modifying its bound fraction and increases the rate of DPH and meta-hydroxydiphenylhydantoin excretion in urine.
D000328:Adult; D005260:Female; D005492:Folic Acid / Q000494:pharmacology*; D006207:Half-Life; D006801:Humans; D006900:Hydroxylation; D007700:Kinetics; D008297:Male; D010672:Phenytoin / Q000097:blood / Q000378:metabolism* / Q000652:urine
D010672:Phenytoin; D005492:Folic Acid