title: Human somatotropin. 55. Synthesis and growth-promoting activity of peptide analogs of the carboxyl terminal plasmin fragment.
abstract: Three analogs of the carboxyl terminal plasmin fragment of human somatotropin, [Nle 170, Ala165, 182, 189]-human somatotropin-(145-191), [Nle170, Ala165, 182, 189]-human somatotropin-(140-191), and [Lys135,136, 138, Glu137, 139, Nle170, Ala165, 182, 189]-human somatotropin-(135-191) have been synthesized by the solid-phase method. The synthetic peptides were assayed for growth-promoting activity and their potency was found to be comparable to that of [S-carbamideomethylcysteine165,182, 189]-human somatotropin-(141-191) which was derived from the native hormone.
mesh_terms: D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D001681:Biological Assay; D013006:Growth Hormone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D007525:Isoelectric Focusing; D010446:Peptide Fragments / Q000494:pharmacology; D010455:Peptides / Q000032:analysis; D051381:Rats; D013977:Tibia / Q000187:drug effects
chemical_list: D000596:Amino Acids; D010446:Peptide Fragments; D010455:Peptides; D013006:Growth Hormone