[Action of vaso-active drugs on gasz of cerebral tissue. Experimental study by mass spectrometry (author's transl)].
The authors describe a method for measuring cerebral tissue respiration by mass spectrometry. The first applications concern the action of vaso-active drugs on intracerebral PCO2 and PO2. The information gained with this method may prove of value in elucidating the mechanisms of drug action and the regulatory mechanisms of cerebral blood flow. Further prospects of experimentation offered by the method are mentioned.
D000818:Animals; D001337:Autonomic Agents / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism*; D002245:Carbon Dioxide / Q000378:metabolism; D002560:Cerebrovascular Circulation / Q000187:drug effects; D004088:Dihydroergotoxine / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D007545:Isoproterenol / Q000494:pharmacology; D013058:Mass Spectrometry / Q000295:instrumentation / Q000379:methods*; D009638:Norepinephrine / Q000494:pharmacology; D010101:Oxygen Consumption / Q000187:drug effects*; D010208:Papaverine / Q000494:pharmacology; D011817:Rabbits
D001337:Autonomic Agents; D004088:Dihydroergotoxine; D002245:Carbon Dioxide; D010208:Papaverine; D007545:Isoproterenol; D009638:Norepinephrine; D004837:Epinephrine
Effets de drogues vaso-actives sur les gaz tissulaires cérébraux. (Etude expérimentale par spectrométrie de masse).