Lysosomal N-acetyl-beta-hexosaminidase and beta-glucuronidase activities from arterial wall. Variations with aging.
Properties of two hydrolases: beta-glucuronidase and N-acetyl-beta-hexosaminidase were studied in lysosomal fractions of media-intima from arterial wall. These enzymatic activities change significantly with aging. In the arterial wall, the decrease in activities of beta-glucuronidase and N-acetyl-beta-hexosaminidase between young and old rats was highly significant while there no notable change in the activities of acid phosphatase. These data are in agreement with the metabolic slow-down and the modifications of the glycosaminoglycan distribution in the media-intima of arterial wall with aging.
D000135:Acid Phosphatase / Q000378:metabolism; D000375:Aging; D000818:Animals; D001013:Aorta, Thoracic / Q000201:enzymology* / Q000648:ultrastructure; D005966:Glucuronidase / Q000378:metabolism*; D006025:Glycosaminoglycans / Q000378:metabolism; D006596:Hexosaminidases / Q000378:metabolism*; D008247:Lysosomes / Q000201:enzymology; D013552:Swine
D006025:Glycosaminoglycans; D000135:Acid Phosphatase; D006596:Hexosaminidases; D005966:Glucuronidase