The distribution of sodium salicylate in the human fetus.
The distribution of sodium salicylate was investigated in the fetuses of 18 mothers in the fifth or sixth month of pregnancy which had to be interrupted for medical reasons. Ninety-six min after drug administration, the salicylic acid levels in mother and fetus blood are almost equal. The highest drug levels in fetus tissue were found in the kidney, the lowest in the brain. In amniotic fluid, only traces of salicylic acid were estimated. A limited number of suitable cases made the exact statistical evaluation impossible.
D000328:Adult; D005260:Female; D005333:Fetus / Q000378:metabolism*; D006801:Humans; D008297:Male; D008431:Maternal-Fetal Exchange; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D012459:Salicylates / Q000097:blood / Q000378:metabolism; D012980:Sodium Salicylate / Q000378:metabolism*; D013997:Time Factors
D012459:Salicylates; D012980:Sodium Salicylate