The estriol/creatinine ratio in a random urine sample as a screening test.
The estriol/creatinine ratio was determined in a first morning urine sample in 1808 pregnancies in the 32nd week of gestation. The ratio obtained correlated closely with birthweight and showed a linear increase with percentile birthweight group. There was a 25-fold increase in perinatal mortality in those pregnancies with a ratio below the tenth percentile; all pregnancies ending in stillbirths with birthweight below the tenth percentile gave such a ratio. The single estrogen/creatinine ratio allowed the early detection of a group of pregnancies at high risk of intrauterine growth retardation or major total abnormality without inconvenience for the patient.
D001724:Birth Weight; D003404:Creatinine / Q000652:urine*; D004964:Estriol / Q000652:urine*; D005260:Female; D005313:Fetal Death / Q000453:epidemiology; D005317:Fetal Growth Retardation / Q000175:diagnosis*; D005865:Gestational Age; D006801:Humans; D007226:Infant Mortality; D007231:Infant, Newborn; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods*; D012306:Risk
D003404:Creatinine; D004964:Estriol