Idiopathic acquired panmyelopathy in pregnancy. A case report.
A case of idopathic acquired panmyelopathy (aplastic anaemia) in pregnancy in a 32-year-old woman is presented. The outcome for mother and child was favourable. Special attention is paid to the management of the delivery. Another aspect of interest is the haematologic status of the child. In panmyelopathy an immunologic mechanism may operate as indicated by the finding of platelet membrane associated immunoglobulins, which were also present in our patient. If the bone marrow lesions in this disease are indeed due to immunological injury, they are mediated by immune complexes or by a cellular mechanism, for it is well know that IgG antibodies may pass through the placenta and induce lysis of circulating blood cells in the newborn. There was no evidence of bone marrow damage in the infant. This is in accordance with the cases mentioned in the literature.
D000741:Anemia, Aplastic / Q000276:immunology; D001792:Blood Platelets / Q000276:immunology; D001803:Blood Transfusion; D001853:Bone Marrow / Q000276:immunology; D002462:Cell Membrane / Q000276:immunology; D002585:Cesarean Section; D005260:Female; D006801:Humans; D007074:Immunoglobulin G; D007231:Infant, Newborn; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000276:immunology; D011947:Receptors, Antigen, B-Cell
D007074:Immunoglobulin G; D011947:Receptors, Antigen, B-Cell