title: Relation of albinism and drugs to the visual evoked potential of the mouse.
abstract: The individual and combined influences of pentobarbital and chlorprothixene on the early components of the cortical visual evoked potential (VEP) were examined in the C57BL/6 mouse. Pentobarbital produced a large increase in latency, and chlorprothixene resulted in a smaller latency increase. When these agents were combined, their effects on the VEP latency were antagonistic. The effects of pentobarbital on VEP amplitude varied as a function of flash intensity, and this barbiturate anesthetic also produced qualitative VEP waveform changes. When the congenic albino (c/c) C57BL/6 was compared with the black (+/+) C57BL/6 mouse; pentobarbital anesthesia produced a decrease of latency with increasing stimulus intensity only in the c/c genotype, whereas VEP amplitudes were similarly affected by pentobarbital in both genotypes.
mesh_terms: D000417:Albinism / Q000503:physiopathology*; D000818:Animals; D002749:Chlorprothixene / Q000494:pharmacology*; D004336:Drug Antagonism; D004338:Drug Combinations; D005071:Evoked Potentials; D005838:Genotype; D051379:Mice; D008810:Mice, Inbred C57BL; D010424:Pentobarbital / Q000494:pharmacology*; D010775:Photic Stimulation; D011930:Reaction Time / Q000187:drug effects; D014793:Visual Cortex / Q000187:drug effects / Q000502:physiology*
chemical_list: D004338:Drug Combinations; D002749:Chlorprothixene; D010424:Pentobarbital