[Effect of acid polysaccharides on the corticosteroid biosynthesis].
Repeated administration of carboxymethylchitin and chondroitinsulfate to rats in doses of 20 and 120 mg/kg/24 hours led to reduction (by 40-55%) of the rate of aldosterone and 18-oxycorticosterone biosynthesis by the rat adrenal glands in vitro. Carboxymethylcellulose, algin and hyaluronic acid displayed no inhibitory effect. In case of a single administration of carboxymethylchitin to rats (50 mg/kg) inhibition of the rate of aldosterone and 18-oxycorticosterone biosynthesis was seen 48 hours after the administration of the preparation and lasted four days. No inhibitory effect was induced by the addition of 10 mg/kg of acid polysaccharides into the incubation medium of the adrenal glands.
D015069:18-Hydroxycorticosterone / Q000096:biosynthesis*; D015070:18-Hydroxydesoxycorticosterone / Q000096:biosynthesis*; D000311:Adrenal Glands / Q000378:metabolism; D000450:Aldosterone / Q000096:biosynthesis*; D000464:Alginates / Q000378:metabolism; D000818:Animals; D002266:Carboxymethylcellulose Sodium / Q000378:metabolism; D002686:Chitin / Q000031:analogs & derivatives / Q000378:metabolism; D002809:Chondroitin Sulfates / Q000378:metabolism; D003345:Corticosterone / Q000031:analogs & derivatives* / Q000096:biosynthesis*; D003900:Desoxycorticosterone / Q000031:analogs & derivatives*; D066298:In Vitro Techniques; D008297:Male; D011134:Polysaccharides / Q000378:metabolism*; D051381:Rats
D015070:18-Hydroxydesoxycorticosterone; D000464:Alginates; D011134:Polysaccharides; D002686:Chitin; D003900:Desoxycorticosterone; D000450:Aldosterone; D015069:18-Hydroxycorticosterone; D002809:Chondroitin Sulfates; D002266:Carboxymethylcellulose Sodium; D003345:Corticosterone
Vliiani kislykh polisakharidov na biosintez kortikosteroidov.