Protein kinase and adenylate cyclase of erythrocyte membrane from patients with Duchenne muscular dystrophy.
In freshly prepared erythrocyte membranes from normal individuals and from patients with Duchenne progressive muscular dystrophy the endogenous protein kinase and the cAMP stimulated phosphorylation was identical for the three main 32P proteins including spectrin (protein band II). Another enzyme, adenylate cyclase, was found unchanged. Altered protein kinase and adenylate cyclase has been reported in this disorder. We have no explanation for these discrepancies.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000262:Adenylyl Cyclases / Q000097:blood*; D004910:Erythrocyte Membrane / Q000201:enzymology*; D004912:Erythrocytes / Q000201:enzymology*; D006801:Humans; D009136:Muscular Dystrophies / Q000201:enzymology*; D011494:Protein Kinases / Q000097:blood*
D000255:Adenosine Triphosphate; D011494:Protein Kinases; D000262:Adenylyl Cyclases