Morphologic abnormalities in potassium-deficient dogs.
Potassium deficiency was produced in 16 dogs by means of a diet containing less than 0.03% potassium. Decreases in serum potassium were first observed after 3 weeks. Morphologic changes occurred only in heart, skeletal muscle, and kidney. Focal myocardial necrosis was observed in 6 of 16 deficient dogs, and skeletal muscle degeneration and necrosis were observed in 14 of 16 deficient dogs. A complex nephropathy consisting primarily of epithelial hypertrophy and hyperplasia in the collecting tubules of the inner stripe of the outer medulla occurred in all the deficient dogs.
D000818:Animals; D004285:Dogs; D005260:Female; D006965:Hyperplasia; D007668:Kidney / Q000473:pathology*; D007672:Kidney Cortex / Q000473:pathology; D007679:Kidney Medulla / Q000473:pathology; D007684:Kidney Tubules / Q000473:pathology; D008297:Male; D009132:Muscles / Q000473:pathology*; D009206:Myocardium / Q000473:pathology*; D011188:Potassium / Q000097:blood; D011191:Potassium Deficiency / Q000473:pathology*; D014617:Vacuoles / Q000473:pathology
D011188:Potassium