Comparative evaluation of two dosages of tinidazole in the treatment of giardiasis.
Forty-five patients with parasitologically confirmed symtomatic giardiasis were treated with tinidazole. A course of 150 mg twice daily for 7 days cured 14 of 19 patients (74%), and a single dose of 2,000 mg cured 24 of 26 (92%). After the single dose, mild side effects were common including maltase, lassitude, and dizziness. Three probable cases of the so-called "postgiardiac syndrome" were seen. Either dosage of tinidazole initially cleared all stool samples of Giardia lamblia, and most clinical and parasitological failures were first detected a few weeks after the treatment. This emphazises the significance of long follow-up periods.
D000328:Adult; D005260:Female; D005873:Giardiasis / Q000188:drug therapy*; D006801:Humans; D008297:Male; D009593:Nitroimidazoles / Q000008:administration & dosage*; D014011:Tinidazole / Q000008:administration & dosage* / Q000627:therapeutic use
D009593:Nitroimidazoles; D014011:Tinidazole