Three-dimensional reconstruction of the fibres of sickle cell haemoglobin.
Three-dimensional reconstruction of electron micrographs of the 20-nm diameter fibres of HbS reveals an inner helical core of four strands surrounded by an outer helix of 10 strands to give a total of 14 strands. The strands are arranged with roughly hexagonal packing to produce an unusual helical structure which features a variety of intermolecular contacts and a non-circular cross section.
D005583:Fourier Analysis; D006451:Hemoglobin, Sickle; D006801:Humans; D046911:Macromolecular Substances; D008854:Microscopy, Electron; D011487:Protein Conformation
D006451:Hemoglobin, Sickle; D046911:Macromolecular Substances