Antihypertensive effects of delta9-tetrahydrocannabinol.
Repeated oral administration of delta9-tetrahydrocannabinol (delta9-THC, 25 mg/kg) reduced systolic blood pressure in conscious spontaneously hypertensive rats. Tolerance to the antihypertensive actions of delta9-THC failed to develop during the 10-day treatment period. The failure of delta9-THC to alter blood pressure in normotensive rats suggests that the hypotensive action of delta9-THC is dependent, in part, on baseline blood pressure.
D000818:Animals; D000959:Antihypertensive Agents; D001831:Body Temperature / Q000187:drug effects; D013759:Dronabinol / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D051381:Rats; D013997:Time Factors
D000959:Antihypertensive Agents; D013759:Dronabinol