Neoplastic transformation induced by a direct perturbation of DNA.
Treatment of Syrian hamster embryo cells with 5-bromodeoxyuridine followed by near ultraviolet irradiation results in neoplastic transformation of these cells. This demonstrates that a direct perturbation of DNA is sufficient to initiate neoplastic transformation.
D001973:Bromodeoxyuridine / Q000528:radiation effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002471:Cell Transformation, Neoplastic / Q000139:chemically induced*; D004247:DNA / Q000528:radiation effects*; D009154:Mutation / Q000187:drug effects / Q000528:radiation effects; D014466:Ultraviolet Rays
D004247:DNA; D001973:Bromodeoxyuridine