The effects of potassium supplements, spironolactone of amiloride on the potassium status of patients with heart failure.
Extra potassium supplements, spironolactone or amiloride were given for 5 months to forty-nine patients with heart failure who were taking furosemide and were in a steady state. Plasma potassium increased with all three treatments but there was no significant increase in total body potassium or red cell potassium. These findings together with other studies suggest that patients with heart failure taking diuretics do not have a significant depletion of body potassium.
D000328:Adult; D000368:Aged; D000584:Amiloride / Q000627:therapeutic use*; D005260:Female; D005665:Furosemide / Q000009:adverse effects; D006333:Heart Failure / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000378:metabolism / Q000627:therapeutic use*; D011191:Potassium Deficiency / Q000139:chemically induced / Q000188:drug therapy*; D011719:Pyrazines / Q000627:therapeutic use*; D013148:Spironolactone / Q000627:therapeutic use*
D011719:Pyrazines; D013148:Spironolactone; D000584:Amiloride; D005665:Furosemide; D011188:Potassium