Hematotoxicity of inhaled benzene to Sprague-Dawley rats and AKR mice at 300 ppm.
Sprague-Dawley rats and AKR/J mice were exposed to 300 ppm benzene vapor for 6 h/d, 5 d/wk, for life. Rats exhibited lymphocytopenia, mild anemia, and moderately decreased survival. Mice showed severe lymphocytopenia and anemia accompanied by granulocytosis and reticulocytosis. Treated mice also showed significantly decreased survival and weight gain. No indications of a leukemic or preleukemic response were observed in either species.
D000818:Animals; D001554:Benzene / Q000097:blood / Q000633:toxicity*; D001772:Blood Cell Count; D004906:Erythrocyte Count; D005978:Glutathione / Q000097:blood; D006402:Hematologic Diseases / Q000139:chemically induced*; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D008938:Mitosis / Q000187:drug effects; D009504:Neutrophils / Q000187:drug effects; D051381:Rats; D013997:Time Factors
D007770:L-Lactate Dehydrogenase; D005978:Glutathione; D001554:Benzene