Plasma kinin activation in tranexamic acid treated patients with hereditary angioneurotic edema.
Plasma kinin formation after in vitro activation of factor XII in the coagulation system was examined in 4 patients with hereditary angioneurotic edema. Compared to controls activationcurves showed a steeper increase and higher maximum levels. Administration of tranexamic acid to the patients resulted in partial normalisation of plasma kinin activation.
D000328:Adult; D000368:Aged; D000799:Angioedema / Q000188:drug therapy*; D003509:Cyclohexanecarboxylic Acids / Q000627:therapeutic use*; D005174:Factor XII / Q000502:physiology; D005260:Female; D006801:Humans; D007705:Kinins / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D014148:Tranexamic Acid / Q000627:therapeutic use*
D003509:Cyclohexanecarboxylic Acids; D007705:Kinins; D014148:Tranexamic Acid; D005174:Factor XII