A rapid method for the labeling of albumin microspheres with In-113 and In-111: concise communication.
A rapid and simple method for preparing microspheres labeled with In-113m or In-111 is described. The procedure requires 10 min and gives labeling yields approaching 100%. Biodistribution studies in rats, mice, and dogs show the product to be biologically stable, with approximately 90% of the injected dose localized in the lung at 1 hr postinjection. The convenient production of In-113m or In-111 albumin microspheres provides an alternate radiopharmaceutical to complement or substitute for Tc-99m microspheres in lung perfusion imaging and other circulation studies.
D000818:Animals; D004285:Dogs; D007204:Indium / Q000378:metabolism; D007553:Isotope Labeling; D008168:Lung / Q000378:metabolism; D051379:Mice; D008863:Microspheres; D010477:Perfusion; D011868:Radioisotopes; D051381:Rats; D012709:Serum Albumin / Q000378:metabolism; D014018:Tissue Distribution
D011868:Radioisotopes; D012709:Serum Albumin; D007204:Indium