A variant of adenovirus 12 producing cytoplasmic accumulation of capsid proteins.
A variant of adenovirus type 12 (R-Ad12) has been isolated by infecting a clonal line of normal rat kidney cells (NRK) with wild-type adenovirus 12. Although R-Ad12 failed to produce infectious progeny virions when cycled a second time through NRK cells, it nevertheless retained the ability to code for virus structural proteins that accumulated in the cytoplasm.
D000260:Adenoviruses, Human / Q000254:growth & development / Q000378:metabolism*; D002213:Capsid / Q000378:metabolism*; D002460:Cell Line; D002999:Clone Cells; D003593:Cytoplasm / Q000378:metabolism*; D004279:DNA, Viral; D010948:Viral Plaque Assay; D014764:Viral Proteins / Q000378:metabolism*
D004279:DNA, Viral; D014764:Viral Proteins