[Hepatocyte regeneration following Kupffer cell stimulation with prodigiosan].
The effect of Bac. prodigiosum polysaccharide named "prodigiosan" on DNA synthesis and the hepatocyte mitotic rate in the regenerating liver of male Wistar rats was studied. Being injected intraperitoneally in a dose of 50 microgram/rad per 24 h before partial hepatectomy prodigiosan markedly increased the mitotic rate and indices of labeled hepatocyte nuclei which reached the maximum values earlier than in control nonstimulated hepatectomized animals. It is suggested that the stimulatory effect of prodigiosan was due to the Kupffer's cells activation.
D000818:Animals; D004247:DNA / Q000096:biosynthesis; D006498:Hepatectomy; D007728:Kupffer Cells / Q000187:drug effects*; D008099:Liver / Q000378:metabolism; D008115:Liver Regeneration / Q000187:drug effects*; D008297:Male; D011353:Prodigiosin / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D004247:DNA; D011353:Prodigiosin
Osobennosti regeneratsii gepatotsitov pri stimuliatsii kupferovskikh kletok prodigiozanom.