title: 8-Carboxy-6-sulfamyldibenz[b,f][1,4]oxazepines and -thiazepines as potential high-ceiling diuretics.
abstract: The synthesis of several 8-carboxy-6-sulfamyldibenz[b,f][1,4]oxazepines and -thiazepines is described. The results of diuretic screening lend support to the thesis that activity is strongly dependent on the conformational mobility of 4-substituents in the 3-amino-5-sulfamylbenzoic acids.
mesh_terms: D000818:Animals; D003987:Dibenzothiazepines / Q000138:chemical synthesis* / Q000494:pharmacology; D003989:Dibenzoxazepines / Q000138:chemical synthesis* / Q000494:pharmacology; D004231:Diuresis / Q000187:drug effects; D004232:Diuretics / Q000138:chemical synthesis*; D005260:Female; D008968:Molecular Conformation; D011188:Potassium / Q000652:urine; D051381:Rats; D012964:Sodium / Q000652:urine; D013329:Structure-Activity Relationship; D013449:Sulfonamides
chemical_list: D003987:Dibenzothiazepines; D003989:Dibenzoxazepines; D004232:Diuretics; D013449:Sulfonamides; D012964:Sodium; D011188:Potassium