title: Specific glycine uptake by identified neurons of Aplysia californica. II. Biochemistry.
abstract: Glycine is taken up twice as rapidly by neurons R3-R14 as by other identified neurons in the Aplysia parietovisceral ganglion. Earlier studies had shown that R3-R14 have much higher glycine concentrations than other Aplysia neurons. Most of the glycine taken up by R3-R14 was biochemically untransformed for at least 1 h following its uptake. Glycine is actively transported into into R3-R14 and other Aplysia neurons by carrier-mediated processes. Glycine uptake by R3-R14 was markedly reduced in the absence of Na+ and in the presence of Hg2+, while these treatments had little effect on glycine uptake by other Aplysia neurons. There appears to be a special glycine uptake system present in R3-R14 and a general glycine uptake system common to all Aplysia neurons. The elevated glycine concentrations and special glycine uptake associated with R3-R14 may indicate that glycine is utilized as a neurotransmitter by those neurons.
mesh_terms: D000409:Alanine / Q000378:metabolism; D000818:Animals; D001048:Aplysia; D001693:Biological Transport, Active / Q000187:drug effects; D046508:Culture Techniques; D005724:Ganglia / Q000166:cytology / Q000378:metabolism*; D005998:Glycine / Q000008:administration & dosage / Q000378:metabolism*; D007930:Leucine / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D009994:Osmolar Concentration; D012694:Serine / Q000378:metabolism; D012964:Sodium / Q000494:pharmacology; D013696:Temperature
chemical_list: D012694:Serine; D012964:Sodium; D007930:Leucine; D000409:Alanine; D005998:Glycine