Pharmacologic and toxicologic study of prostaglandin F2alpha in cattle.
Prostaglandin F 1alpha (tham salt formulation) was injected IM into mature beef heifers at the rate of 0, 25, 75, 125, or 250 mg (4 heifers/dose group) on days 2 and 10, or 0 and 25 mg (4 heifers/dose group) on days 1 through 10. Drug effects were evaluated by means of 19 clinical observations, measurements of body weight and 10 organ weights, 15 clinical chemistry measurements, 9 hematologic measurements, 7 urinalysis measurements, and gross and microscopic observations of 27 tissues. Prostaglandin F2alpha administered on days 1 and 10 or daily for 10 days produced little evidence of pharmacologic effects and no evidence of toxicologic effects. Pharmacologic effects  included a slight transitory increase in heart rate in all treated groups and slight hyperthermia in the 250-mg group. Failure to produce important  toxicologic effects at 250 mg/day and with luteolytic doses occurring around 15 to 25 mg/day demonstrated that the safety factor was in excess of 10 X.
D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001663:Bilirubin / Q000097:blood; D002417:Cattle / Q000097:blood / Q000502:physiology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006400:Hematocrit; D007273:Injections, Intramuscular; D007958:Leukocyte Count; D011460:Prostaglandins F / Q000008:administration & dosage / Q000494:pharmacology / Q000633:toxicity*; D011517:Prothrombin Time
D011460:Prostaglandins F; D000469:Alkaline Phosphatase; D001663:Bilirubin