[Narcosis, platelet aggregation and arousing drugs].
During pentobarbital (25 mg/kg i.v. in 2 min), pentothal (15 mg/kg i.v. in 2 min) and ketamine (10 mg/kg i.v. in 2 min) narcosis, rabbits showed reduced platelet reactivity ot the direct aggregating effect of ADP (2 X 10(-5) M) and the indirect effect of thrombin (0.1 U/ml). Certain arousal drugs, specifically those of metabolic type such as SAMe (20 mg/kg i.v. in 2 min) and Thiola (166 mg/kg i.v. in 2 min) and of haemodynamic type such as nicergoline (6.66 mg/kg i.v. in 2 min) and hexobendine (5 mg/kg i.v. in 2 min) administered 31 min after narcosis induction, impede the depression brought on by narcosis on on platelet reactivity.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000758:Anesthesia; D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D005260:Female; D006592:Hexobendine / Q000494:pharmacology; D007649:Ketamine / Q000494:pharmacology; D008297:Male; D009530:Nicergoline / Q000494:pharmacology; D010634:Phenobarbital / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects*; D011817:Rabbits; D012436:S-Adenosylmethionine / Q000494:pharmacology; D013874:Thiopental / Q000494:pharmacology; D013917:Thrombin / Q000494:pharmacology; D008625:Tiopronin / Q000494:pharmacology
D000777:Anesthetics; D000244:Adenosine Diphosphate; D007649:Ketamine; D012436:S-Adenosylmethionine; D006592:Hexobendine; D008625:Tiopronin; D013917:Thrombin; D009530:Nicergoline; D013874:Thiopental; D010634:Phenobarbital
Narcosi, aggregazione delle piastrine e risveglianti.