The efficacy of practolol-induced beta1 adrenergic blockade in the canine heart.
The efficacy of adrenergic blockade with practolol was assessed by subjecting 6 adult mongrel dogs in a closed-chest procedure to bolus injections of isoproterenol (0.5 mcg/kg, i.v.) before and after practolol (2.0 mg/kg, i.v.). Following practolol both heart rate and pulse pressure responses were significantly reduced. It is suggested that significant beta1 receptor adrenergic blockade is achieved by practolol.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D005260:Female; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D007545:Isoproterenol / Q000037:antagonists & inhibitors*; D008297:Male; D011217:Practolol / Q000494:pharmacology*; D011674:Pulse / Q000187:drug effects
D007545:Isoproterenol; D011217:Practolol