[Effect of pyridoxylate on the intensity of changes in the internal organs and skeletal musculature of rats under considerable physical loading].
Under considerable physical load, marked enzymopathy, increased permeability of cellular membranes with the involvement of cellular and subcellular structures develop in the myocardium, skeletal musculature and viscera of rats. Administration of pyridozylate decreases the intensity of damage reactions and normalizes to a certain degree the structure of cellular and subcellular elements of tissues. This indicates the advisability of the employment of the cell respiration regulators under conditions of general and tissue hypoxy and metabolic shifts.
D000818:Animals; D005221:Fatigue / Q000378:metabolism / Q000473:pathology* / Q000517:prevention & control; D006651:Histocytochemistry; D000860:Hypoxia / Q000378:metabolism / Q000473:pathology* / Q000517:prevention & control; D007539:Isonicotinic Acids / Q000627:therapeutic use*; D007668:Kidney / Q000473:pathology; D008099:Liver / Q000473:pathology; D008297:Male; D009132:Muscles / Q000473:pathology*; D009206:Myocardium / Q000473:pathology; D011735:Pyridoxic Acid / Q000627:therapeutic use*; D051381:Rats
D007539:Isonicotinic Acids; D011735:Pyridoxic Acid
Vliianie piridoksilata na vyrazhennost' izmeneniĭ vnutrennoĭ organov i skeletnoĭ muskulatury krys pri znachitel'noĭ fizicheskoĭ nagruzke.