Effects of saralasin on blood pressure, renin and renal blood flow in unilateral renovascular hypertension.
The effect of saralasin, a competitive inhibitor of angiotensin II, was assessed in hypertensive patients with unilateral renal artery stenosis after furosemide application. A significant fall of systemic arterial blood pressure, an increase of renal venous renin activity, significantly on the stenosed side in patients without arteriosclerosis of the contralateral kidney, and an almost equal decrement of renal blood flow in both kidneys were observed. Conceivably saralasin exerts different sodium-dependent effects on peripheral angiotensin II and specific intrarenal vascular receptors.
D000804:Angiotensin II / Q000031:analogs & derivatives*; D001161:Arteriosclerosis / Q000150:complications; D001794:Blood Pressure / Q000187:drug effects*; D005260:Female; D006801:Humans; D006977:Hypertension, Renal / Q000503:physiopathology*; D006978:Hypertension, Renovascular / Q000150:complications / Q000201:enzymology / Q000503:physiopathology*; D007668:Kidney / Q000098:blood supply*; D008297:Male; D012039:Regional Blood Flow / Q000187:drug effects; D012077:Renal Artery; D012078:Renal Artery Obstruction / Q000150:complications; D012082:Renal Veins; D012083:Renin / Q000097:blood*; D012504:Saralasin / Q000494:pharmacology*
D000804:Angiotensin II; D012083:Renin; D012504:Saralasin