Podophyllin poisoning. Systemic toxicity following cutaneous application.
The toxicity of topically applied podophyllin in a 16-year-old girl is presented. Coma requiring respiratory support and major neurologic complications as well as hematologic and hepatic toxicity was observed. Therapy with a new modality, charcoal hemoperfusion, resulted in resolution of the acute toxicity, leaving a peripheral neuropathy which had not completely resolved after 4 months. The pharmacology and suggested treatment measures for the toxicity of this rarely reported agent are reviewed.
D000287:Administration, Topical; D000293:Adolescent; D002606:Charcoal; D055598:Chemical Phenomena; D002621:Chemistry; D003218:Condylomata Acuminata / Q000188:drug therapy; D005260:Female; D006464:Hemoperfusion; D006801:Humans; D011033:Podophyllin / Q000008:administration & dosage / Q000506:poisoning* / Q000627:therapeutic use; D011034:Podophyllotoxin / Q000627:therapeutic use; D012867:Skin / Q000187:drug effects; D014846:Vulvar Neoplasms / Q000188:drug therapy
D002606:Charcoal; D011033:Podophyllin; D011034:Podophyllotoxin