Further studies on liver glyoxalase I and glyoxalase II. Activity in mice bearing sarcoma 180 and L1210 leukemia.
Determinations were made of glyoxalase I and glyoxalase II acitivity in the liver of mice (BDF1 and DBA2 strains) bearing sarcoma 180 and L1210 leukemia in ascites form. A progressive decrease in the both glyoxalase I and glyoxalase II activities to about 40--60% of that of the control groups was observed within the developing period 8--9 days. Test results are interpreted in the light of the postulated role of this enzyme system in cell division and in the tumor development process.
D000818:Animals; D002455:Cell Division; D005978:Glutathione / Q000031:analogs & derivatives; D007791:Lactoylglutathione Lyase / Q000378:metabolism* / Q000502:physiology; D007939:Leukemia L1210 / Q000201:enzymology* / Q000209:etiology; D008099:Liver / Q000201:enzymology*; D008190:Lyases / Q000378:metabolism*; D051379:Mice; D008815:Mice, Inbred Strains; D012510:Sarcoma 180 / Q000201:enzymology* / Q000209:etiology; D013869:Thiolester Hydrolases / Q000378:metabolism* / Q000502:physiology; D013997:Time Factors; D000099301:Hydroxyacylglutathione Hydrolase
D005978:Glutathione; D007791:Lactoylglutathione Lyase; D008190:Lyases; D013869:Thiolester Hydrolases; D000099301:Hydroxyacylglutathione Hydrolase