title: Animal models of the hormone-sensitive and -insensitive prostatic adenocarcinomas, Dunning R-3327-H, R-3327-HI, and R-3327-AT.
abstract: The Dunning R-3327-H is a well-differentiated transplantable rat prostatic adenocarcinoma that contains both hormone-sensitive and -insensitive cells. The component composed of hormone-insensitive cells has been permitted to grow in a castrated male, and a new slow-growing, well-differentiated hormone-insensitive subline of the tumor has been established and designated R-3327-HI. In addition, a rapidly growing hormone-insensitive anaplastic tumor has been developed, R-3327-AT. These three tumor lines have been characterized, and their histological and biochemical profiles are compared.
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D009374:Neoplasms, Experimental / Q000378:metabolism; D009376:Neoplasms, Hormone-Dependent / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D051381:Rats; D011944:Receptors, Androgen; D011960:Receptors, Estrogen; D011987:Receptors, Steroid
chemical_list: D011944:Receptors, Androgen; D011960:Receptors, Estrogen; D011987:Receptors, Steroid