[Effect of insulin on coronary vessel adrenergic and cholinergic reactions].
The effect of a single insulin injection on the reaction of the coronary vessels to adrenaline, noradrenaline, and acetylcholine was studied in experiments on dogs. Insulin induces a decrease of arterial pressure and of the resistance of the coronary and peripheral vessels reduces the reflex cholinergic and beta-adrenergic reactions of dilatation of the coronary vessels, and promotes alpha-adrenergic reactions in intracoronary administration of adrenaline and noradrenaline. Insulin also weakens the immediate cholinergic reactions of the coronary vessels in stimulation of the effector systems with acetylcholine.
D000818:Animals; D001775:Blood Circulation / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D002496:Central Venous Pressure / Q000187:drug effects; D003331:Coronary Vessels / Q000187:drug effects*; D004285:Dogs; D005260:Female; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D011941:Receptors, Adrenergic / Q000187:drug effects*; D011950:Receptors, Cholinergic / Q000187:drug effects*; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects
D007328:Insulin; D011941:Receptors, Adrenergic; D011950:Receptors, Cholinergic
Vliianie insulina na adrenergicheskie i kholinergicheskie reaktsii koronarykh sosudov.