The syndromes of hydatidiform mole. I. Cytogenetic and morphologic correlations.
Cytogenetic and morphologic analysis of 23 hydatidiform moles allowed the division into at least two syndromes: (1) the syndrome of complete (classical) mole is without an ascertainable embryo/fetus, gives a diploid karyotype, and manifests a progressive fluid engorgement of the villi as well as a gross, haphazardly distributed trophoblastic hyperplasia; (2) the syndrome of partial (incomplete) mole has an ascertainable fetus (alive or dead), gives a triploid karyotype, and exhibits a slowly progressing hydatidiform swelling in the presence of functioning villous capillaries that spares many villi; trophoblastic immaturity is constant and focal hyperplasia is inconspicuous but present. A single case of diploid mole with unusual morphologic features, complete with a fetus, may herald yet another syndrome. Human chorionic gonadotropin levels were initially high in practically all cases. There was no malignant trophoblastic disease in this small series, but a plea is made that partial moles be followed carefully in order to establish their relation to choriocarcinoma.
D000293:Adolescent; D000328:Adult; D006063:Chorionic Gonadotropin / Q000378:metabolism; D002824:Chorionic Villi / Q000473:pathology; D004171:Diploidy; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000145:classification / Q000235:genetics / Q000473:pathology; D006965:Hyperplasia; D007621:Karyotyping; D011123:Polyploidy; D011247:Pregnancy; D013577:Syndrome; D014327:Trophoblasts / Q000473:pathology; D014594:Uterine Neoplasms / Q000145:classification / Q000235:genetics / Q000473:pathology
D006063:Chorionic Gonadotropin