Cyclophosphamide-like cellular immunostimulation induced by 6-thioguanine (Lanvis).
The possible immunostimulating effect of 6-thioguanine was studied in the mouse. It caused a dose-dependent suppression of the cellular and humoral immune response if administered 1 day before immunization. If, however, the interval between 6-thioguanine administration and immunization was extended to 5 days, a significant enhancement of delayed hypersensitivity was observed. The The enhancement occurred only after immunization with 10(6) and 10(7) sheep red cells. The analogy between the immunostimulating effects of 6-thioguanine and cyclophosphamide is discussed.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006968:Hypersensitivity, Delayed; D007111:Immunity, Cellular / Q000187:drug effects; D007114:Immunization; D007165:Immunosuppression Therapy; D008297:Male; D051379:Mice; D013866:Thioguanine / Q000494:pharmacology* / Q000633:toxicity; D013997:Time Factors
D013866:Thioguanine