Effect of pyridoxal administration on the contents of pyridoxal phosphate and gamma-aminobutyric acid in mouse brain.
Many mice treated with a high single dose of PL died in convulsions. The convulsions were very similar to those induced with some anti B6 in several ways: (1) a long latent period occurs betfore convulsions; (2) PLP levels in brain decrease; (3) GABA levels in brain, especially in synaptosomal fraction, decrease. The possibility that a deranged GABA metabolism in nerve ending may be a major cause of the convulsions is discussed.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D005968:Glutamate Decarboxylase / Q000378:metabolism; D051379:Mice; D011730:Pyridoxal / Q000494:pharmacology* / Q000633:toxicity; D011732:Pyridoxal Phosphate / Q000378:metabolism*; D013347:Subcellular Fractions / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D011730:Pyridoxal; D005680:gamma-Aminobutyric Acid; D011732:Pyridoxal Phosphate; D005968:Glutamate Decarboxylase