[Effect of strychnine, hydrastine and apamin on synaptic transmission in smooth muscle cells].
The effects of strychnine, hydrastine and apamine on nervemuscle transmission in guinea pig stomach and taenia coli were studied. Hydrastine and strychnine produced an increase in non-adrenergic IPSPs of smooth muscle cells. Under apamine action IPSPs and hyperpolarization caused by exogenous ATP were reversibly blocked and non-cholinergic EPSPs appeared. ATP caused depolarization of the cell membrane in this condition. Consequently, apamine is a specific (postsynaptic) blocking agent of non-adrenergic inhibition and ATP obviously mediates both non-adrenergic inhibition and non-cholinergic synaptic excitation of smooth muscle cells observed in our experiments.
D000255:Adenosine Triphosphate / Q000494:pharmacology; D000470:Alkaloids / Q000494:pharmacology; D000818:Animals; D001030:Apamin / Q000494:pharmacology*; D001514:Bee Venoms / Q000494:pharmacology*; D044182:Benzylisoquinolines; D003106:Colon / Q000187:drug effects; D004347:Drug Interactions; D006168:Guinea Pigs; D007546:Isoquinolines / Q000494:pharmacology*; D008564:Membrane Potentials / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D009469:Neuromuscular Junction / Q000187:drug effects*; D009928:Organ Specificity; D013270:Stomach / Q000187:drug effects; D013331:Strychnine / Q000494:pharmacology*; D013570:Synaptic Membranes / Q000187:drug effects
D000470:Alkaloids; D001514:Bee Venoms; D044182:Benzylisoquinolines; D007546:Isoquinolines; D001030:Apamin; C013024:hydrastine; D000255:Adenosine Triphosphate; D013331:Strychnine
Vliianie strikhnina, gidrastina i apamina na sinapticheskuiu peredachu v gladkomyshechnykh kletkakh.