[Anti-arrhythmic activity of trimecaine under experimental and clinical conditions].
The antiarrhythmic properties of trimecaine, a local anesthetic, were studied. Tests on cats and rats with arrhythmia induced by stimulation with electric current and injection of aconitine, barium chloride, and calcium chloride as well as on a cell model of aconitine arrhythmia have shown that trimecaine possesses marked antiarrhythmic properties. It is more active and less toxic than procainamide hydrochloride or quinidine. Oral administration of 0.35% trimecaine solution had a favourable therapeutic effect in extrasystole in patients with complex heart valvular diseases and circulatory disorders. It is presumed that parenteral injection will produce a more rapid and prolonged antiarrhythmic effect.
D000083:Acetanilides / Q000031:analogs & derivatives*; D000284:Administration, Oral; D000818:Animals; D000889:Anti-Arrhythmia Agents; D001145:Arrhythmias, Cardiac / Q000188:drug therapy* / Q000517:prevention & control; D002415:Cats; D002642:Chick Embryo; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D011817:Rabbits; D051381:Rats; D014288:Trimecaine / Q000008:administration & dosage / Q000627:therapeutic use*
D000083:Acetanilides; D000889:Anti-Arrhythmia Agents; D014288:Trimecaine
Protivoaritmicheskaia aktivnost' trimekaina v eksperimente i klinike.