Differential plus polarographic determination of submicrogram quantities of carmustine and related compounds in biological samples.
A polarographic method was developed to determine the antineoplastic agent carmustine and other nitrosoureas, such as N-methyl-N-nitrosourea and N-cyclohexyl-N-nitrosourea, in biological fluids at levels well below 1 microgram/ml or g. The stability of carmustine in different media was investigated to prevent losses during administration or assay. Examples of nitrosourea determination in biological samples are given.
D000818:Animals; D002330:Carmustine / Q000032:analysis* / Q000097:blood / Q000378:metabolism; D004355:Drug Stability; D066298:In Vitro Techniques; D008297:Male; D008722:Methods; D051379:Mice; D008832:Microchemistry; D008862:Microsomes, Liver / Q000378:metabolism; D009607:Nitrosourea Compounds / Q000032:analysis*; D011048:Polarography; D051381:Rats
D009607:Nitrosourea Compounds; D002330:Carmustine