The effects of aflatoxin B1 on rat fetal lung lipids.
The administration of aflatoxin B1 to rats on days 17 and 19 of pregnancy caused increased synthesis of the total lipids and the fatty acids, and decreased synthesis of the phosphatidyl choline in 21-day-old fetal lung. Aflatoxin B1 caused toxicity in the fetal lung as evidenced by the excessive accumulation of the lamellar bodies and the osmiophilic spheroids in the type II cells and the alveolar lumen, respectively. The rearrangement of the lamellar form to the continuous sheet-like tubular myelin form was reduced in the alveolar lumen of the treated lung.
D000348:Aflatoxins / Q000008:administration & dosage / Q000633:toxicity*; D000818:Animals; D005227:Fatty Acids / Q000096:biosynthesis; D005260:Female; D005865:Gestational Age; D007274:Injections, Intraperitoneal; D008055:Lipids / Q000096:biosynthesis*; D008168:Lung / Q000187:drug effects* / Q000196:embryology / Q000378:metabolism; D010713:Phosphatidylcholines / Q000096:biosynthesis; D010743:Phospholipids / Q000096:biosynthesis; D011247:Pregnancy; D051381:Rats
D000348:Aflatoxins; D005227:Fatty Acids; D008055:Lipids; D010713:Phosphatidylcholines; D010743:Phospholipids