Antitumor agents 32. Synthesis and antitumor activity of cyclopentenone derivatives related to helenalin.
Several new cyclopentenones related to helenalin have been synthesized as potential alkylating antitumor agents. The procedure involved the transformation of 2-methyl-2-carbethoxycyclopentanone (2) to an ethylene ketal 3, bromination of 3 followed by dehydrobromination to yield a ketal olefin 5, reduction of 5 to the alcohol 6, conversion of 6 to the corresponding hydroxycyclopentenone 7, and estrification of 7 to afford the cyclopentenone esters 8--11. Biological assays indicated that only cyclopentenones possessing a conjugated ester side chain, such as 9 and 10, demonstrated significant in vitro cytotoxicity against the growth of tissue culture cells originating from human epidermoid carcinoma of the larynx (H.Ep.-2) as well as in vivo antitumor activity in Walker 256 carcinosarcoma in rats and P-388 lymphocytic leukemia in mice.
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis / Q000627:therapeutic use; D002279:Carcinoma 256, Walker / Q000188:drug therapy; D002478:Cells, Cultured; D003517:Cyclopentanes / Q000138:chemical synthesis* / Q000627:therapeutic use; D007942:Leukemia, Experimental / Q000188:drug therapy; D007945:Leukemia, Lymphoid / Q000188:drug therapy; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D051381:Rats; D012717:Sesquiterpenes / Q000138:chemical synthesis / Q000627:therapeutic use; D045789:Sesquiterpenes, Guaiane
D000972:Antineoplastic Agents, Phytogenic; D003517:Cyclopentanes; D012717:Sesquiterpenes; D045789:Sesquiterpenes, Guaiane; C001329:helenalin