title: Myocardial ultrastructural changes after experimental ventricular fibrillation and anoxic arrest.
abstract: A transmural myocardial biopsy method was used to study changed in ultrastructure after induced ventricular fibrillation or anoxic arrest in the canine heart. Interstitial edema, mitochondrial derangement, contraction bands, and swelling of capillary endothelium were more extensive in subendocardial than in subepicardial layer after anoxic arrest. Significant numbers of contraction bands were also seen in the myocardium after induced ventricular fibrillation. These changes appeared to be reversible at least in part in the group with induced ventricular fibrillation but generally not in the anoxic arrest animals. After anoxic arrest, preservation of the endocardial layer was significantly poorer than that of the epicardium; after ventricular fibrillation, there appeared to be no such difference. Myocardial mitochondria and glycogen granules were intact and more numerous after ventricular fibrillation than after anoxic arrest. The lesser damage after ventricular fibrillation than after anoxic arrest suggest that the myocardium may be affected less by the no-reflow phenomenon after normal coronary circulation is restored in ventricular fibrillation.
mesh_terms: D000818:Animals; D004285:Dogs; D006003:Glycogen / Q000378:metabolism; D006323:Heart Arrest / Q000503:physiopathology*; D006439:Hemodynamics; D000860:Hypoxia / Q000503:physiopathology*; D008929:Mitochondria, Heart / Q000648:ultrastructure; D009206:Myocardium / Q000648:ultrastructure*; D014693:Ventricular Fibrillation / Q000503:physiopathology*
chemical_list: D006003:Glycogen