Lichen planus and discoid lupud erythematosus. Overlap syndrome associated with cryoglobulinemia and hypocomplementemia.
A patient with the discoid lupus erythematosus and lichen planus overlap syndrome has profound depression of serum C4 concentration associated with substantial mixed cryoblobulinemia. A family study failed to disclose evidence of a familial hypocomplementemia, cryoglobulinemia, or a dermatologic condition. Immunologlobulin, but no complement, was detected at the site of the skin abnormality. This case illustrates an immune-complex disorder with a mixed cryoglobulinemia that is related to immunoglobulin deposition in the skin.
D003181:Complement C4 / Q000172:deficiency; D003165:Complement System Proteins / Q000172:deficiency*; D003450:Cryoglobulins; D005260:Female; D006680:HLA Antigens; D006801:Humans; D008010:Lichen Planus / Q000150:complications* / Q000235:genetics / Q000276:immunology; D008179:Lupus Erythematosus, Discoid / Q000150:complications* / Q000235:genetics / Q000276:immunology; D008875:Middle Aged; D010265:Paraproteinemias / Q000150:complications* / Q000235:genetics / Q000276:immunology; D012217:Rheumatoid Factor; D013577:Syndrome
D003181:Complement C4; D003450:Cryoglobulins; D006680:HLA Antigens; D003165:Complement System Proteins; D012217:Rheumatoid Factor