Comparison of bladder carcinogenesis by nitrosomethyldodecylamine in Sprague--Dawley and Fischer rats carrying transplanted bladder tissue.
Nitrosomethyldodecylamine was given by gavage in oliver oil solution (25 mg twice/week) to male and female Sprague--Dawley and Fischer rats to the back of each of which had been transplanted a suspension of urinary bladder tissue from the same strain. While there was 100% incidence of transitional cell carcinomas in the host urinary bladders, and few other tumors in the animals, there was a tumor in only 1 transplant in a Sprague--Dawley rat, with a possible tumor in another, and none in the Fischer rat, although these were inbred. In a significant number of cases the transplant survived.
D000818:Animals; D002295:Carcinoma, Transitional Cell / Q000139:chemically induced*; D005260:Female; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009602:Nitrosamines / Q000633:toxicity*; D009928:Organ Specificity; D051381:Rats; D011916:Rats, Inbred F344; D013045:Species Specificity; D014184:Transplantation, Homologous; D014185:Transplantation, Isogeneic; D001743:Urinary Bladder / Q000637:transplantation; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced*
D009602:Nitrosamines