Quantitative TLC determination of propranolol in human plasma.
A spectrodensitometric assay was developed for propranolol based on measurement of the absorbance of the drug on silica gel plates irradiated at 822 nm. Quantities as low as 0.10 microgram can be detected, and a linear relationship was obtained between 0.010 and 0.400 microgram. The percent recovery from plasma spiked with known amounts of the drug was 90.0--102.0. This procedure was used to determine propranolol in the  plasma of patients receiving therapeutic doses of the drug.
D002855:Chromatography, Thin Layer; D006801:Humans; D008722:Methods; D011433:Propranolol / Q000097:blood*
D011433:Propranolol