Central therapeutic effects of dihydroderivative of pralidoxime (pro-2-PAM) in organophosphate intoxication.
Central actions of pro-2-PAM (dihydroderivative of 2-PAM) and 2-PAM in poisonings with DFP have been studied. It was shown that pro-2-PAM significantly increased activity of DFP inhibited acetylcholinesterase in the brain, quickly ceased the DFP-induced paralysis of respiration, partially normalized the DFP-induced abnormalities in electrocorticogram and increased the convulsive dosis of DFP. Effects of 2-PAM in these experiments were negligible.
D000818:Animals; D000927:Anticonvulsants; D002540:Cerebral Cortex / Q000503:physiopathology; D002800:Cholinesterase Inhibitors; D004569:Electroencephalography; D005260:Female; D066298:In Vitro Techniques; D007531:Isoflurophate / Q000506:poisoning; D008297:Male; D062025:Organophosphate Poisoning; D011220:Pralidoxime Compounds / Q000494:pharmacology / Q000627:therapeutic use*; D011817:Rabbits; D051381:Rats; D012133:Respiratory Paralysis / Q000517:prevention & control; D013997:Time Factors
D000927:Anticonvulsants; D002800:Cholinesterase Inhibitors; D011220:Pralidoxime Compounds; D007531:Isoflurophate