Effects of 4-ipomeanol, a product from mold-damaged sweet potatoes, on the bovine lung.
Cattle given intraruminal administration of 4-ipomeanol, a furanoterpenoid originally obtained from sweet potatoes infected with Fusarium solani (F. javanicum), developed a respiratory syndrome clinically and histologically indistinguishable from atypical interstitial pneumonia. There were edema and emphysema in the lungs and mediastinum. The maximum nonlethal oral dose of 4-ipomeanol was estimated to be between 7.5 and 9 mg/kg of body weight.
D000818:Animals; D002417:Cattle; D005260:Female; D005663:Furans / Q000633:toxicity; D005670:Fusarium; D008168:Lung / Q000473:pathology; D011016:Pneumonia, Atypical Interstitial, of Cattle / Q000139:chemically induced* / Q000473:pathology; D013729:Terpenes / Q000633:toxicity*; D014675:Vegetables
D005663:Furans; D013729:Terpenes; C001470:4-ipomeanol