[Effect of combined administration of estradiol and progesterone on the mitotic cycle of the epithelial tissues of the reproductive tract of ovariectomized white rats].
The duration of stages of the cell cycle in the uterine and vaginal tissues of ovariectomized rats, treated with estradiol and estradiol-progesterone, was estimated using the labeled mitosis method. The joint treatment shortened G2 period in epithelial tissues. In the uterine epithelial tissues of estradiol-progesterone treated rats, the duration of S period was prolonged. In all tissues, progesterone stimulated the entry of cells into a second round of DNA synthesis. The estrogen-gestagen treatment inhibited the movement of vaginal epithelial cells from basal to superficial layers.
D000818:Animals; D002369:Castration; D002453:Cell Cycle / Q000187:drug effects*; D004347:Drug Interactions; D004717:Endometrium / Q000187:drug effects*; D004848:Epithelium / Q000187:drug effects; D004958:Estradiol / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D011374:Progesterone / Q000008:administration & dosage* / Q000494:pharmacology; D051381:Rats; D014621:Vagina / Q000187:drug effects*
D011374:Progesterone; D004958:Estradiol
Vliianie sovmestnogo vvedeniia éstradiola i progesterona na mitoticheskiĭ tsikl épitelial'nykh tkaneĭ reproduktivnogo trakta ovariéktomirovannykh belykh krys.