Resistance to a transplantable rat mammary tumor (DMBA 8BT) after pre-treatment with syngeneic fetal cells.
Mid-term syngeneic fetal cells, injected according to an optimal schedule, protect female Fischer 344 rats against a transplantable mammary tumor (DMBA 8BT). This protection is complete against an inoculum of up to 5 x 10(5) cells, an amount which leads to a 100% tumor take without pre-treatment. Multiparity does not protect against this tumor model.
D000230:Adenocarcinoma / Q000276:immunology*; D000367:Age Factors; D000818:Animals; D002478:Cells, Cultured; D005260:Female; D005333:Fetus / Q000276:immunology*; D007114:Immunization; D008325:Mammary Neoplasms, Experimental / Q000276:immunology*; D009368:Neoplasm Transplantation; D051381:Rats; D011916:Rats, Inbred F344; D013997:Time Factors; D014184:Transplantation, Homologous