title: Modification of the toxicity of acetylcholine by prior atropinization in mice.
abstract: The potentiation of acetylcholine (Ach) toxicity in mice with prior atropinization was tested. The experiments were carried out with three doses of 200 mg, 300 mg, and 400 mg/kg of Ach administered ip. Prior atropinization was observed to potentiate the Ach toxicity at all dose levels of atropine except the highest in the group that received Ach 200 mg/kg and the results were variable in the other two groups.
mesh_terms: D000109:Acetylcholine / Q000037:antagonists & inhibitors / Q000633:toxicity*; D000818:Animals; D001285:Atropine / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D005260:Female; D008297:Male; D051379:Mice
chemical_list: D001285:Atropine; D000109:Acetylcholine