Serological studies of seromucoids from normal subjects and patients with malignant and non-malignant diseases.
During investigations of serum from patients with carcinoma, elevated levels of two proteins were observed. The larger (MW approximately 44,000) was identified as (alpha-acid glycoprotein. The smaller MW approximately 20,000) has not yet been identified. Further investigation of alpha-acid-glycoprotein-containing seromucoid showed that many red blood cell and tissue antigens were present, for example, I, i, P1, Tja (P+P+Pk), H, A, B, Lea, Leb1, M and N. Differences in antigen content between normal serum and serum from carcinoma patients could be demonstrated quantitatively and qualitatively. Seromucoid preparations from patients with Hodgkin's lymphoma inhibited phytohaemagglutinin-induced lymphocyte transformation more often than seromucoid preparations from normal subjects.
D000017:ABO Blood-Group System; D001789:Blood Group Antigens; D001943:Breast Neoplasms / Q000276:immunology; D002850:Chromatography, Gel; D006023:Glycoproteins / Q000276:immunology; D006689:Hodgkin Disease / Q000276:immunology; D006801:Humans; D007122:Immunoelectrophoresis; D008213:Lymphocyte Activation; D008223:Lymphoma / Q000276:immunology; D009961:Orosomucoid / Q000276:immunology*; D010127:P Blood-Group System; D014947:Wounds and Injuries / Q000276:immunology
D000017:ABO Blood-Group System; D001789:Blood Group Antigens; D006023:Glycoproteins; D009961:Orosomucoid; D010127:P Blood-Group System