[Radiation sensitivity of the amelanotic hamstermelanoma in vitro and in vivo (author's transl)].
Radiation sensitivity of the hamster melanoma AMel 3 was studied in vivo and in vitro. In vitro, a dose-effect curve with the dose Do=155 rd and the extrapolation number 10 was obtained. In consideration of an oxygen enhancement factor of 2.5, the results of in-vivo examination with the quantitative transplantation method did not differ from in-vitro results. In living animals, about 40% of the tumor cells generally are hypoxic. These data do not verify the hypothesis of a particular radiation resistance of melanoma cells.
D000818:Animals; D006224:Cricetinae; D000860:Hypoxia; D008545:Melanoma / Q000532:radiotherapy*; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000532:radiotherapy; D011836:Radiation Tolerance; D011879:Radiotherapy Dosage; D012878:Skin Neoplasms / Q000532:radiotherapy
Die Strahlenempfindlichkeit des amelanotischen Hamstermelanoms in vitro und in vivo.