[Action of furosemide in experimental acute renal failure (author's transl)].
The action of furosemide was studied in glycerol-induced acute renal failure of rats. Acute renal failure was induced by an intramuscular injection of 50% glycerol (10 ml/kg). A marked increase in plasma urea concentration was found after the glycerol injection. Urea concentration increased to a maximal value of 339 +/- 67 mg/100 ml at the third day after glycerol application. 36% of the animals died within the first 4 days after glycerol. Furosemide (20 mg/kg) was injected intraperitoneally daily and for the first time 24 h after injection of glycerol Mortality and azotemia of acute renal failure was not improved by this drug.
D058186:Acute Kidney Injury / Q000139:chemically induced / Q000188:drug therapy*; D000818:Animals; D005665:Furosemide / Q000627:therapeutic use*; D005990:Glycerol; D008297:Male; D051381:Rats; D014508:Urea / Q000097:blood
D005665:Furosemide; D014508:Urea; D005990:Glycerol
Untersuchungen zur Wirksamkeit von Furosemid bei experimentellen akuten Nierenversagen.