title: Time-related contrast enhancement of blood, normal muscle, and V2 carcinoma in the rabbit as determined by CT scanning.
abstract: After a bolus of intravenous Renografin, the delivery and washout of contrast in malignant V2 carcinoma, normal muscle, and blood using CT scanning was evaluated over a two-hour period. Diagnostically useful differences in enhancement between V2 carcinoma and muscle predictably lasted one hour, but in selected rabbits lasted longer. Delivery and washout was greater in tumor than in normal muscle, and it was these differences which accounted for the diagnostically useful differences in enhancement. After two hours, attenuation in V2 and normal muscle remained elevated, while blood returned to nearly control levels, suggesting a large amount of contrast distributed throughout the extravascular space and probably in equilibrium with excretion.
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000378:metabolism; D005260:Female; D006614:Hindlimb; D009132:Muscles / Q000000981:diagnostic imaging* / Q000378:metabolism; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000000981:diagnostic imaging / Q000378:metabolism; D011817:Rabbits; D011856:Radiographic Image Enhancement / Q000379:methods*; D012983:Soft Tissue Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism; D013997:Time Factors; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media