title: Splenic visualization using 99mTc-methylene diphosphonate in a patient with sickle cell disease.
abstract: Splenic visualization with a bone-seeking agent 99mTc-methylene diphosphonate (99mTc-MDP) with absence of splenic uptake using sulfur colloid was seen in a 15-year-old boy in sickle cell crisis. Uptake of 99mTc-MDP is probably due to splenic infarction and calcification. This represents a potentially sensitive method for following the functional auto-splenectomy process in sickle cell disease and may also detect the presence of splenic tissue when it is not visualized in a sulfur colloid liver/spleen scan. Splenic visualization by bone-seeking agents should not be confused with skeletal lesions or indicate the presence of an abnormal left upper quadrant mass lesion.
mesh_terms: D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000000981:diagnostic imaging*; D004164:Diphosphonates; D006801:Humans; D008297:Male; D011877:Radionuclide Imaging; D013154:Spleen / Q000000981:diagnostic imaging*; D013667:Technetium
chemical_list: D004164:Diphosphonates; D013667:Technetium