Experiments on the chemotheraphy of a transplantable glioblastoma in the rat, employing 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU).
A glioblastoma was induced in BD-II rats by weekly i.v. injections of methylnitrosourea and transplanted intracerebrally in numerous passages. The take rate was 100%. For the experiments with CCNU, solid pieces of tumour were implanted into the right parietal region. The cytostatically treated animals lived significantly longer. The untreated tumour rats had an average survival time of 18 days (counted from the time of transplantation), and the rats treated with CCNU had an average survival time of 28 days. The median values were 19 and 28 days.
D000818:Animals; D001932:Brain Neoplasms / Q000188:drug therapy*; D005910:Glioma / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D008130:Lomustine / Q000627:therapeutic use*; D008297:Male; D008770:Methylnitrosourea; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology; D009607:Nitrosourea Compounds / Q000627:therapeutic use*; D051381:Rats
D009607:Nitrosourea Compounds; D008770:Methylnitrosourea; D008130:Lomustine