Where do general anaesthetics act?
General anaesthetics were found to have no effect on lipid bilayer structures when studied using X-ray and neutron diffraction. Combined gaseous and aqueous phase solubility data suggested that the primary site of action of general anaesthetics has both polar and nonpolar characteristics, and probably involves protein.
D000777:Anesthetics / Q000494:pharmacology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002784:Cholesterol; D005740:Gases; D008565:Membrane Proteins; D008567:Membranes, Artificial; D009502:Neutrons; D009821:Oils; D010713:Phosphatidylcholines; D012542:Scattering, Radiation; D012995:Solubility; D014867:Water; D014961:X-Ray Diffraction
D000777:Anesthetics; D005740:Gases; D008565:Membrane Proteins; D008567:Membranes, Artificial; D009821:Oils; D010713:Phosphatidylcholines; D014867:Water; D002784:Cholesterol