[Role of lysosomes in immunodepression].
Degrading of heterologous protein--bovine serum albumin--under the action of lysosomes inhibited the immunodepressive preparations with chlorophos and 2,4-dichlorphenoxyacetic acid (2,4-D). Immunodepressors (chlorophos, 2,4-D, cyclophosphane, phosphestrol, methotrexate, ftuoruracil) suppressed the activity of cathepsin, whereas dibasol--an immunostimulant--failed to alter its activity. The principal possibility of the selective immunodepression at the level of lysosome enzymes is substantiated.
D000818:Animals; D002403:Cathepsins / Q000037:antagonists & inhibitors; D007165:Immunosuppression Therapy; D007166:Immunosuppressive Agents / Q000494:pharmacology; D066298:In Vitro Techniques; D008099:Liver / Q000648:ultrastructure; D008247:Lysosomes / Q000201:enzymology / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D012710:Serum Albumin, Bovine / Q000378:metabolism
D007166:Immunosuppressive Agents; D012710:Serum Albumin, Bovine; D002403:Cathepsins
O roli lizosom v immunodepressii.