Antiinflammatory activities of polymers of o-metacryloyloxybenzoic acid.
Antiinflammatory activities of low- and high- molecular-weight polymers of o-methacryloyloxybenzoic acid were compared with the antiinflammatory activity of o-acetoxybenzoic (acetylsalicylic) acid in tests on hind-leg inflammations in rats induced by injection of either Freund's adjuvant or aqueous suspension of kaolin. The antiinflammatory activies of the orally administered polymers cooresponded to 40-90% of the activity of o-acetoxybenzoic acid, and were not substantially dependent on the degree of polymerization.
D000180:Acrylic Resins / Q000627:therapeutic use*; D000818:Animals; D001241:Aspirin / Q000627:therapeutic use; D007249:Inflammation / Q000188:drug therapy*; D011109:Polymethacrylic Acids / Q000627:therapeutic use*; D051381:Rats
D000180:Acrylic Resins; D011109:Polymethacrylic Acids; D001241:Aspirin