Lethal encephalitis in 14-day-old mice given avirulent Semliki forest virus.
Avirulent Semliki Forest Virus when inoculated intracerebrally and intraperitoneally into 14-day-old Swiss A2G mice induced a lethal encephalitis. There was destruction of neurones, especially pyramidal cells of the hippocampus, despite a rising serum antibody titer.
D000367:Age Factors; D000818:Animals; D001102:Arbovirus Infections / Q000473:pathology / Q000662:veterinary*; D001921:Brain / Q000473:pathology; D004660:Encephalitis / Q000473:pathology / Q000662:veterinary*; D051379:Mice; D012376:Rodent Diseases / Q000473:pathology*; D012672:Semliki forest virus