title: [Possible role of lysosomal proteinases in the biological effects of G-forces].
abstract: Experiments on rats demonstrated that acceleration of 6 g for 10 min elevated significantly the activity of acid proteinases and the rate of their release from lysosomes into the incubation mixture. Hydrocortisone (1 mg/100 g body weight) also increased proteinase activity; however, this effect was transient and less expressed. Upon a combined effect of hydrocortisone and acceleration the effect of the latter on the activity of lysosomal enzymes weakened appreciably.
mesh_terms: D000054:Acceleration; D000818:Animals; D006854:Hydrocortisone / Q000494:pharmacology*; D008099:Liver / Q000201:enzymology / Q000648:ultrastructure*; D008247:Lysosomes / Q000201:enzymology*; D008297:Male; D010447:Peptide Hydrolases / Q000378:metabolism*; D010539:Permeability; D051381:Rats
chemical_list: D010447:Peptide Hydrolases; D006854:Hydrocortisone
vernacular_title: O vozmozhnoĭ roli lizosomal'nykh proteinaz v biologicheskikh éffektakh peregruzki.