title: Transforming activities of trichloroethylene and proposed industrial alternatives.
abstract: Three chlorinated hydrocarbons, proposed or already in use as industrial substitutes for the hydrocarbon trichloroethylene, were tested for in vitro transforming potential in a Fischer rat embryo cell system (F1706), which previously has been shown to be sensitive to transformation by chemical carcinogens. Trichloroethylene and the three substitutes (1, 1, 1 trichloroethane, tetrachloroethylene and methylene chloride) all were found to induce transformation, the three substitutes being equal or more efficient transforming agents.
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D004353:Drug Evaluation, Preclinical; D006843:Hydrocarbons, Chlorinated / Q000494:pharmacology*; D008752:Methylene Chloride / Q000494:pharmacology*; D009368:Neoplasm Transplantation; D051381:Rats; D013750:Tetrachloroethylene / Q000494:pharmacology*; D014240:Trichloroethanes / Q000494:pharmacology*; D014241:Trichloroethylene / Q000494:pharmacology*
chemical_list: D006843:Hydrocarbons, Chlorinated; D014240:Trichloroethanes; D014241:Trichloroethylene; D008752:Methylene Chloride; D013750:Tetrachloroethylene