On the quantitative importance of omega-oxidation of fatty acids.
The relative importance of omega-oxidation of fatty acids in livers of starved rats was studied by determination of the ratio between 14C at C1 and at C2, C3, C4 in acetoacetate formed from [16-14C]palmitic acid in vivo and in vitro and from [10(-14)C]decanoic acid in vitro. The results are consistent with the possibility that at least a small fraction of the fatty acids may be subject to primary omega-oxidation prior to beta-oxidation in the ketotic state. The maximal figure for this pathway was calculated to be of the magnitude 5--10%. The metabolic consequences of a pathway involving primary omega-oxidation of fatty acids are discussed.
D000090:Acetoacetates / Q000378:metabolism; D000818:Animals; D003652:Decanoic Acids / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism*; D007662:Ketosis / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D010084:Oxidation-Reduction; D010169:Palmitic Acids / Q000378:metabolism; D051381:Rats; D013217:Starvation / Q000378:metabolism
D000090:Acetoacetates; D003652:Decanoic Acids; D005227:Fatty Acids; D010169:Palmitic Acids