title: [Changes in the peripheral blood lymphocytes after immunization and its effect on the course of experimental inflammatory process in the lungs].
abstract: It was shown that in the immunization of rabbits with sorbed staphylococcus toxoid and human albumin, at the height of the immune response there occurred an intensification of biosynthesis and destabilization of lysosomal membranes of blood leukocytes, with a simultaneous development of microcirculation disturbances in the lungs. Development of pneumonia against the background of immunization led to a greater destabilization of the lysosomic membranes of leukocytes and to the intensification in the lungs of infiltrative and destructive processes, in comparison with the course of inflammation in the nonimmunized animals. Peculiarities of the antigens used caused some specificity in the course of pneumonia. A relationship between the changes of blood leukocytes and disturbances in the lungs in immunization is supposed.
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D000917:Antibody Formation; D002462:Cell Membrane / Q000378:metabolism; D003852:Deoxyribonucleoproteins / Q000378:metabolism; D006801:Humans; D007114:Immunization; D008168:Lung / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology* / Q000473:pathology; D011014:Pneumonia / Q000276:immunology*; D011817:Rabbits; D012261:Ribonucleoproteins / Q000378:metabolism; D012709:Serum Albumin / Q000276:immunology*; D013208:Staphylococcal Toxoid / Q000276:immunology*
chemical_list: D003852:Deoxyribonucleoproteins; D012261:Ribonucleoproteins; D012709:Serum Albumin; D013208:Staphylococcal Toxoid; D000135:Acid Phosphatase
vernacular_title: Izmeneniia leĭkotsitov perifericeskoĭ krovi pri immunizatsii i ee vliianie na techenie eksperimental'nogo vospalitel'nogo protsessa v legkikh.