Effect of taurocholate on the conversion of 3alpha, 7alpha, 12alpha-trihydroxy-5beta-cholestan-26-oic acid into cholic acid.
To determine if the conversion of the intermediate, 3alpha, 7alpha, 12alpha-trihydroxy-5beta-cholestan-26-oic acid (THCA), into cholic acid is influenced by taurocholate, two rats were infused intravenously with [3H] THCA until they reached a steady state. Taurocholate was then added and infused at a rate of 1 mumole/min/rat for 48 hours. The percentage of [3H] THCA recovered in the bile did not increase indicating that taurocholate does not suppress the conversion of THCA into cholic acid.
D000818:Animals; D001646:Bile / Q000378:metabolism; D001647:Bile Acids and Salts / Q000378:metabolism*; D002777:Cholestanols / Q000378:metabolism*; D002793:Cholic Acids / Q000096:biosynthesis*; D008297:Male; D051381:Rats; D013656:Taurocholic Acid / Q000494:pharmacology*; D013997:Time Factors
D001647:Bile Acids and Salts; D002777:Cholestanols; D002793:Cholic Acids; D013656:Taurocholic Acid