Blood-group-I activity associated with band 3, the major intrinsic membrane protein of human erythrocytes.
Affinity chromatography of radioiodinated solubilized erythrocyte stroma and of radioiodinated purified Band 3 on an anti-(blood-group I)-adsorbent column showed blood-group-I activity associated with a subpopulation of Band 3. The specificity of binding was confirmed by inhibition with known blood-group substances in radioimmunoassays.
D001789:Blood Group Antigens; D002846:Chromatography, Affinity; D004591:Electrophoresis, Polyacrylamide Gel; D004910:Erythrocyte Membrane / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology*; D006801:Humans; D007048:I Blood-Group System; D008565:Membrane Proteins / Q000276:immunology*
D001789:Blood Group Antigens; D007048:I Blood-Group System; D008565:Membrane Proteins