title: Effect of dietary methionine level on anserine and carnosine contents in the gastrocnemius muscle of rat.
abstract: Anserine and carnosine in the muscle of growing rats were measured to explore the effect of dietary methionine. Carnosine was reduced in the gastrocnemius muscle of rats fed on a methionine-free diet. After refeeding on methionine for one week, carnosine in the muscle approached to the normal level. In contrast, anserine increased in the muscle of rats fed on a methionine-free diet. Anserine also increased in the gastrocnemius muscle of rats fed on a methionine-excess diet, whereas carnosine did not vary. Npi-Methylhistidine was detected in the muscle of rats fed on a methionine-excess diet. Moreover, Npi-methylhistindine and Ntau-methylhistine in the urine increased in the rats fed on both methionine-excess and methionine-free diets. Carnosine in the gastrocnemius muscle was not affected by a ethionine diet nor by a orotic acid diet which induced fatty liver. However, anserine increased in the muscle of rats fed on a ethionine diet.
mesh_terms: D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D000861:Anserine / Q000378:metabolism*; D002336:Carnosine / Q000378:metabolism*; D004247:DNA / Q000378:metabolism; D004151:Dipeptides / Q000378:metabolism*; D008297:Male; D008715:Methionine / Q000378:metabolism / Q000494:pharmacology*; D009124:Muscle Proteins / Q000378:metabolism; D009132:Muscles / Q000187:drug effects / Q000378:metabolism*; D012313:RNA / Q000378:metabolism; D051381:Rats
chemical_list: D000596:Amino Acids; D004151:Dipeptides; D009124:Muscle Proteins; D012313:RNA; D002336:Carnosine; D004247:DNA; D008715:Methionine; D000861:Anserine