title: Hemodynamic effects of smoking cigarettes of high and low nicotine content.
abstract: We studied the hemodynamic effects of smoking cigarettes with high and low contents of nicotine in young smokers free of coronary arterial disease. The smoking of one cigarette with a high content of nicotine produced a peak rise in cardiac output of 32 percent above baseline values, and the effect persisted for one hour. Smoking a cigarette with a low content of nicotine produced a peak rise of 13 percent above baseline values, with a duration of five minutes. The rise in cardiac output was almost entirely attributable to tachycardia, since stroke volume remained relatively constant. The smoking of a cigarette with high nicotine content also caused greater and more sustained elevation in systemic blood pressure than smoking a cigarette with low nicotine content. Thus, there was a responsiveness to the dose of nicotine in cigarettes smoked by young smokers free of coronary arterial disease.
mesh_terms: D000293:Adolescent; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D009538:Nicotine / Q000494:pharmacology*; D012907:Smoking / Q000503:physiopathology*
chemical_list: D009538:Nicotine