Brief report. In vitro effects of Rubella virus, strain RA 27/3, on human lymphocytes. III. Inhibition of mitogen stimulation transferred by supernatants from virus-infected cultures.
When lymphocytes from humans with serological immunity against rubella were incubated with live rubella virus, supernatants were obtained which when added to non-infected lymphocytes gave a significant inhibition of phytohaemagglutinin (PHA)-induced proliferation. In contrast, supernatants from virus-infected lymphocytes from donors lacking immunity against rubella gave no inhibition of the PHA response.
D002478:Cells, Cultured; D006801:Humans; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D010835:Phytohemagglutinins / Q000494:pharmacology; D012412:Rubella virus / Q000276:immunology
D010835:Phytohemagglutinins