The effects of chronic ethanol administration on acyl group composition of mitochondrial phospholipids from guinea pig adrenal.
The acyl groups of diacyl-glycerophosphocholine1 (GPC) and diacyl-glycerophosphoethanolamine (GPE) in guinea pig adrenals are comprised mainly of 16:0, 18:0, 18:1, 18:2 and 20:4(n-6) with only trace amounts of the longer chain polyunsaturated fatty acids. There was an increase in the proportions of 18:2 and a decrease in the 20:4(n-6) of diacyl-GPC and diacyl-GPE with respect to chronic ethanol administration. Acyl group changes were more obvious in diacyl-GPC than in diacyl-GPE. It is conceivable that these changes may lead to an alteration of other membrane transport activities as well as functions of the adrenal gland.
D000311:Adrenal Glands / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D000818:Animals; D000431:Ethanol / Q000494:pharmacology*; D051379:Mice; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D010713:Phosphatidylcholines / Q000378:metabolism; D010714:Phosphatidylethanolamines / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism*
D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D010743:Phospholipids; D000431:Ethanol