[Clinical immunological observations of persons in a period of prolonged hypokinesia and the readaptation thereafter].
In order to study the role of autoimmune processes in the origin of changes occurring during prolonged bed rest, 9 young male test subjects were examined during 30-day and 21--49 day bed rest experiments and recovery periods. No antibodies to antigens of the heart, liver, and kidneys were found. Ten out of 21 test subjects at the end of bed rest and 12 test subjects during recovery showed a high titer of the circulating cardiac antigen. Electro-, mechano, and polycardiographic stadies demonstrated that the subjects with the circulating cardiac antigen displayed more marked changes in the ECG T-wave and the contractile function of the myocardium. These changes were accompanied by activation of the enzymes ALT, ACT and LDH.
D000222:Adaptation, Physiological; D000941:Antigens / Q000032:analysis; D001323:Autoantibodies / Q000032:analysis*; D002320:Cardiovascular Physiological Phenomena; D004562:Electrocardiography; D006339:Heart Rate; D006439:Hemodynamics; D006801:Humans; D007103:Immobilization; D007668:Kidney / Q000276:immunology; D008099:Liver / Q000276:immunology; D008297:Male; D009206:Myocardium / Q000276:immunology; D013997:Time Factors
D000941:Antigens; D001323:Autoantibodies
Kliniko-immunologicheskie nabliudeniia za liud'mi v period dlitel'noĭ gipokinezii i readaptatsii posle nee.