2,3,7,8-tetrachlorodibenzo-p-dioxin as cocarcinogen causing 3-methylcholanthrene-initiated subcutaneous tumors in mice genetically "nonresponsive" at Ah locus.
D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000096:biosynthesis / Q000235:genetics*; D003238:Connective Tissue / Q000201:enzymology; D004147:Dioxins / Q000633:toxicity*; D004790:Enzyme Induction / Q000187:drug effects; D005796:Genes; D008099:Liver / Q000201:enzymology; D008748:Methylcholanthrene; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D000072317:Polychlorinated Dibenzodioxins / Q000633:toxicity*; D012513:Sarcoma, Experimental / Q000139:chemically induced*; D012867:Skin / Q000201:enzymology; D012983:Soft Tissue Neoplasms / Q000139:chemically induced*
D004147:Dioxins; D000072317:Polychlorinated Dibenzodioxins; D008748:Methylcholanthrene; D001189:Aryl Hydrocarbon Hydroxylases