title: The genetics of blind--a lethal factor in mice.
abstract: The linkage relationships of the lethal gene blind (Bld) in the mouse were investigated. The gene is located on chromosome 15, between uw and bt. The distance uw--Bld is 28.2 +/- 5.1 cM: Bld--bt is 14.9 +/- 2.7 cM: and Bld--Ca is 24.6 +/- 2.6 cM. Incomplete penetrance and/or reduced viability of Bld/+ animals was found when blind animals were crossed to several strains, but the cross female DBA/2J X male blind yielded complete penetrance and specificity. Evidence is presented for the presence of X-linked modifiers affecting the penetrance and possible increased viability of Bld in strain DBA.
mesh_terms: D000818:Animals; D001766:Blindness / Q000235:genetics*; D003433:Crosses, Genetic; D005260:Female; D005804:Genes, Lethal; D008040:Genetic Linkage; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010641:Phenotype; D014960:X Chromosome