Hepatic parasympathetic neural effect on glucose balance in the intact liver.
Sympathetic nerves to the intact liver of the cat were selectively destroyed by injection of 6-hydroxydopamine into the portal vein 1 week prior to the experiment. Glucose output was calculated from the product of the arterial-venous glucose difference and hepatic blood flow. Hepatic blood flow was monitored by an electromagnetic flowmeter using a hepatic venous long-circuit. Stimulation of the parasympathetic nerves isolated from around the common hepatic artery produced a rapid reduction in hepatic glucose output to one-quarter of control levels by 2 min and to zero by 10 min of nerve stimulation. The data show that hepatic glucose balance is readily influenced by the hepatic parasympathetic nerves.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D002415:Cats; D005947:Glucose / Q000378:metabolism*; D006892:Hydroxydopamines / Q000494:pharmacology; D008099:Liver / Q000294:innervation* / Q000378:metabolism; D008102:Liver Circulation; D010275:Parasympathetic Nervous System / Q000502:physiology*; D013564:Sympathetic Nervous System / Q000187:drug effects; D013997:Time Factors
D001786:Blood Glucose; D006892:Hydroxydopamines; D005947:Glucose