title: Evaluation of a combined oestrogen-progestogen injectable contraceptive.
abstract: A combined injection of 50 mg medroxyprogesterone acetate and 10 mg oestradiol cypionate (Cyclo-Provera; Upjohn) was administered monthly for periods ranging from 1 to 18 months, to 120 Black women of reproductive age. No major side-effects were noted, no pregnancies occurred in the 575 cycles studies, and the pattern of regular menstrual bleeding was acceptable. Amenorrhoea occurred in 15,8% of patients but only 2,5% requested a change of treatment. The incidence of amenorrhoea diminished with continued use. This contraceptive regimen appears to be a useful addition to the methods presently available. Certain aspects merit further study.
mesh_terms: D000293:Adolescent; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D004338:Drug Combinations; D004341:Drug Evaluation; D004958:Estradiol / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D045166:Estradiol Congeners / Q000009:adverse effects; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008525:Medroxyprogesterone / Q000008:administration & dosage* / Q000009:adverse effects; D008599:Menstruation Disturbances / Q000139:chemically induced
chemical_list: D004338:Drug Combinations; D045166:Estradiol Congeners; D004958:Estradiol; C007630:estradiol 17 beta-cypionate; D008525:Medroxyprogesterone