The effect of peripherally administered 6-hydroxydopamine on food and water intake in rats.
The effect of peripheral administration of a single dose of 6-hydroxydopamine (6-OHDA; 100 mg/kg i.p.) on ingestive behaviours in adult rats has been studied. Individual food and water intakes were measured daily for a period of 7 days following treatment. Most animals became hypophagic for up to 72 hours and hypodipsic for up to 24 hours. The possibility that peripherally administered 6-OHDA may enter the CSF by means of the circum-ventricular organs and thereby exert central behavioural effects is discussed.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001812:Blood-Brain Barrier / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects; D004327:Drinking Behavior / Q000187:drug effects*; D005247:Feeding Behavior / Q000187:drug effects*; D006892:Hydroxydopamines / Q000008:administration & dosage / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008297:Male; D051381:Rats
D006892:Hydroxydopamines