The effect of Imuran on pancreatic secretion. A preliminary report.
The acute administration of Imuran and hydrocortisone significantly decrease pancreatic flow and protein output in canines. This observed phenomenon may explain the gastrointestinal side reactions encountered in clinical usage of these potent immunosuppresants.
D000818:Animals; D001379:Azathioprine / Q000494:pharmacology*; D001639:Bicarbonates / Q000378:metabolism; D004285:Dogs; D004357:Drug Synergism; D006854:Hydrocortisone / Q000494:pharmacology; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism
D001639:Bicarbonates; D011506:Proteins; D001379:Azathioprine; D006854:Hydrocortisone