Polymorphism of tissue and serum amyloid A (AA and SAA) proteins in the mouse.
Amino acid sequence studies of the amino terminal 25 residues of amyloid A (AA) protein and the serum precursor (SAA) induced with casein or LPS indicate differences in the sequence at position 6 and significant heterogeneity at several other positions in SAA. These findings suggest that SAA is a polymorphic serum protein and raise the possibility that only certain forms of SAA are processed to the tissue amyloid fibril.
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D000682:Amyloid / Q000032:analysis / Q000378:metabolism; D000686:Amyloidosis / Q000097:blood; D000818:Animals; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D004591:Electrophoresis, Polyacrylamide Gel; D008099:Liver / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains; D008970:Molecular Weight; D011110:Polymorphism, Genetic; D011498:Protein Precursors / Q000032:analysis / Q000097:blood; D013154:Spleen / Q000378:metabolism
D000596:Amino Acids; D000682:Amyloid; D011498:Protein Precursors