Effects of steroid hormones on the binding of ioglycamide (bilivistan) to human blood serum.
The binding relationships between ioglycamide and steroid hormones were determined in a liquid two-phase system with labelled ioglycamide and by direct measurement of ultraviolet light absorption. It was found that an interaction between ioglycamide and steroid hormones, particularly progesterone, existed, relative to the binding to human serum protein.
D001667:Binding, Competitive; D001798:Blood Proteins / Q000378:metabolism*; D004347:Drug Interactions; D004958:Estradiol / Q000097:blood / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000494:pharmacology*; D007457:Iodine Radioisotopes; D007463:Iodobenzoates / Q000378:metabolism*; D007471:Ioglycamic Acid / Q000378:metabolism*; D008598:Menstruation; D008968:Molecular Conformation; D011374:Progesterone / Q000097:blood / Q000494:pharmacology*; D011485:Protein Binding / Q000187:drug effects; D013739:Testosterone / Q000097:blood / Q000494:pharmacology*
D001798:Blood Proteins; D007457:Iodine Radioisotopes; D007463:Iodobenzoates; D013739:Testosterone; D011374:Progesterone; D004958:Estradiol; D007471:Ioglycamic Acid; D006854:Hydrocortisone