Influence of steroid aerosol treatments on the clearance of inhaled gold particles.
Female Long Evans rats were used to test the hypothesis that in haled triamcinolone acetonide accelerates the rate of clearance of particles from the lung. Three groups of animals inhaled a radioactive gold aerosol, which functioned as a tracer of respiratory tract clearance, and then were subjected to various inhalation treatments. The group treated with triamcinolone acetonide aerosol showed a significant acceleration in the rate of early clearance, but the total amount of tracer particles cleared in the first day was not significantly increased. Inhaled triamcinolone acetonide appears to accelerate the translocation of foriegn particles from small airways to larger ones, but stimulation of clearance does not appear to be a large effect.
D000336:Aerosols; D000818:Animals; D004347:Drug Interactions; D005260:Female; D006046:Gold / Q000378:metabolism*; D006207:Half-Life; D051381:Rats; D013997:Time Factors; D014222:Triamcinolone Acetonide / Q000494:pharmacology*
D000336:Aerosols; D006046:Gold; D014222:Triamcinolone Acetonide