Studies in potential organo-fluorine oral hypoglycemic agents. Part 6: Synthesis and biological activities of some fluorinated 2-arylsulfonamido-5-alkyl-1.3.4-thiadiazoles.
Forty new fluorinated 2-arylsulfonamido-5-alkyl-1.3.4-thiadiazoles have been synthesized and a representative number of synthesized compounds have been screened for their hypoglycemic activity and some other types of biological activities.
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis; D001786:Blood Glucose / Q000378:metabolism; D001831:Body Temperature / Q000187:drug effects; D007004:Hypoglycemic Agents / Q000138:chemical synthesis*; D008297:Male; D051379:Mice; D051381:Rats; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D014235:Trichinellosis / Q000188:drug therapy
D000998:Antiviral Agents; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D013830:Thiadiazoles