[Glycemia and insulinemia of vitamin A deficient rats after administration of glucose].
We have studied the variations of the blood glucose and insulin concentrations of control and vitamin A-deficient rats after administration of glucose by various ways. The avitaminosis decreases the initial glycaemia and insulinaemia in fasting rats. It seems that the insulin release from the pancreas of the deficient rats is normal after a moderate treatment: for example after a single injection of glucose 0,5 g/kg in the carotide, or during the digestion of a mixed meal (rats trained to eat their day's food in a short time), or during an intestinal perfusion in vivo of weak concentrated glucose solutions (0,5 to 2 g/l). But after meal feeding a glucose rich diet (65 p. cent) or during intestinal perfusions of solutions with a higher glucose content (up to 15 g/l) the hyper-insulinaemia is fleeting in the deficient rats and its appeared highest hyperglycaemia in some perfused animals. The endocrine regulations of the vitamin A-deficient rats are considered in the discussion.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D005247:Feeding Behavior; D005947:Glucose / Q000008:administration & dosage; D006943:Hyperglycemia / Q000209:etiology; D006946:Hyperinsulinism / Q000209:etiology; D007328:Insulin / Q000097:blood*; D008297:Male; D051381:Rats; D014802:Vitamin A Deficiency / Q000150:complications / Q000378:metabolism*
D001786:Blood Glucose; D004040:Dietary Carbohydrates; D007328:Insulin; D005947:Glucose
Glycémie et insulinémie du rat carencé en vitamine A aprés surcharge glucosée.