Protective effects of a series of new pyridinium derivatives against inhibition of acetylcholinesterase by fluostigmine.
The protective effects of a series of new pyridinium derivatives against inhibition of acetylcholinesterase (AChE) by fluostigmine was studied in vitro on human erythrocytes. It was stated that some of these compounds exhibit protective action for AChE against inhibition by fluostigmine. The best protective index had N-methyl-4-[gamma-pyridyl]-pyridinium iodide.
D000110:Acetylcholinesterase / Q000097:blood; D000818:Animals; D002800:Cholinesterase Inhibitors; D004912:Erythrocytes / Q000201:enzymology; D006801:Humans; D066298:In Vitro Techniques; D007531:Isoflurophate / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D011726:Pyridinium Compounds / Q000494:pharmacology* / Q000633:toxicity
D002800:Cholinesterase Inhibitors; D011726:Pyridinium Compounds; D007531:Isoflurophate; D000110:Acetylcholinesterase