Action of cytidine diphosphocholine on functional and hemodynamic effects of cerebral ischemia in cats.
The depression of evoked cortical potentials caused by brief periods of cerebral ischemia is attenuated by prior intracarotid injection of cytidoline (2, 4 or 8 mg/kg). Studies performed in hypercapnic cats suggest that the protection afforded by cytidoline is of metabolic rather than hemodynamic origin. The participation of the central dopaminergic structures by the drug is suggested according to the previous data.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002415:Cats; D002540:Cerebral Cortex / Q000187:drug effects; D002794:Choline / Q000031:analogs & derivatives*; D003566:Cytidine Diphosphate Choline / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D002546:Ischemic Attack, Transient / Q000188:drug therapy* / Q000503:physiopathology
D003566:Cytidine Diphosphate Choline; D002794:Choline