title: Metabolism of [14C] terbutryn (2-(t-butylamino)-4-(ethylamino)-6-(methylthio-s-triazine) by rats and goat.
abstract: Sixteen metabolites of terbutryn were isolated from the urine and feces of either rats or a goat given single oral doses of terbutryn-[14C](2-(t-butylamino)-4-(ethylamino)-6-(methylthio)-s-triazine). The metabolites resulted from one or more of the following changes: S-demethylation, conversion of the methylthio group to a hydroxy group; N-deethylation; oxidation of the terminal carbon of the ethyl group to a carboxylic acid; oxidation of a terminal carbon of the t-butyl group to either an alcohol or a carboxylic acid; or conjugation with glucuronic acid.
mesh_terms: D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D005243:Feces / Q000032:analysis; D005260:Female; D006041:Goats; D006540:Herbicides; D013058:Mass Spectrometry; D051381:Rats; D014018:Tissue Distribution; D014227:Triazines / Q000378:metabolism* / Q000652:urine; D014297:Trimethylsilyl Compounds
chemical_list: D006540:Herbicides; D014227:Triazines; D014297:Trimethylsilyl Compounds