title: Globomycin, a new peptide antibiotic with spheroplast-forming activity. III. Structural determination of globomycin.
abstract: The structure of globomycin has been determined by mass, PMR and CMR spectra and by chemical degradation. Globomycin is a new cyclic peptide antibiotic composed of L-serine, L-allo-threonine, glycine, N-methylleucine, L-allo-isoleucine and 3-hydroxy-2-methylnonaic acid. Among these components, L-allo-threonine, L-allo-isoleucine and 3-hydroxy-2-methylnonaic acid are novel components from natural products. A newly developed mass analysis has been introduced for determining the diastereoisomers of allo-threonine.
mesh_terms: D000596:Amino Acids / Q000032:analysis; D000900:Anti-Bacterial Agents; D055598:Chemical Phenomena; D002621:Chemistry; D006868:Hydrolysis; D013058:Mass Spectrometry; D008968:Molecular Conformation; D010084:Oxidation-Reduction; D010455:Peptides
chemical_list: D000596:Amino Acids; D000900:Anti-Bacterial Agents; D010455:Peptides