Effects of cyproterone acetate on the testicular function of bat (Rhinopoma kinneari Wroughton).
1-Cyproterone acetate administration (0.2 mg/day/animal for 25 days) caused widespread testicular necrosis. The lumen of the epididymides were devoid of spermatozoa. The RNA, protein, sialic acid and phosphatase enzyme activity of the testes were reduced. Serum transaminase enzyme activity was slightly changed. Haemoglobin, hematocrit, blood sugar, and blood urea levels were in the normal range. Regressed Leydig cell tissue and decreased production of RNA and sialic acid in the testes could be due to the antiandrogenic action produced by cyproterone acetate.
D000818:Animals; D002685:Chiroptera / Q000502:physiology*; D003534:Cyproterone / Q000494:pharmacology*; D003864:Depression, Chemical; D008099:Liver / Q000187:drug effects; D008297:Male; D013091:Spermatogenesis / Q000187:drug effects; D013737:Testis / Q000032:analysis / Q000187:drug effects*
D003534:Cyproterone