Synthesis of some new analogs of the immunoadjuvant glycopeptide MDP (N-acetyl-muramyl-L-alanyl-D-isoglutamine).
In our continued efforts to elucidate the relationship between the structure and the immunoadjuvant, antiinfectious or mitogenic activity of N-acetyl-muramyl-L-alanyl-D-isoglutamine (MDP), we report the synthesis of 11 new analogs. Five of them present some modifications in the N-acetyl-muramyl moiety.
D000276:Adjuvants, Immunologic / Q000138:chemical synthesis*; D000595:Amino Acid Sequence; D000890:Anti-Infective Agents / Q000494:pharmacology; D006020:Glycopeptides / Q000138:chemical synthesis* / Q000494:pharmacology; D008934:Mitogens / Q000494:pharmacology
D000276:Adjuvants, Immunologic; D000890:Anti-Infective Agents; D006020:Glycopeptides; D008934:Mitogens