title: [Role of intestinal hormones in the pathogenesis of experimental pancreatitis].
abstract: In acute experiments on dogs with preliminarily induced pancreatitis the authors traced disturbances of the secretory reactions of the pancreas in response to adequate stimulation with the intestinal hormones. There was a reduction in the activity of complex intestinal hormones preparations obtained from the duodenal mucosa at the acute period of the disease in these dogs. In chronic experiments there was found an increase of acid production debit in the stomach and a shift in the duodenal contents reaction in the acid direction in pancreatitis. A conclusion was drawn on an important pathogenetic role played by the intestinal hormones in the mechanism of disturbances of the pancreatic exocrine secretion in pancreatitis.
mesh_terms: D000681:Amylases / Q000378:metabolism; D000818:Animals; D002217:Carbachol; D002766:Cholecystokinin; D004285:Dogs; D005750:Gastric Juice / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism*; D006632:Histamine; D008049:Lipase / Q000378:metabolism; D010179:Pancreas / Q000378:metabolism*; D010195:Pancreatitis / Q000503:physiopathology*; D010447:Peptide Hydrolases / Q000378:metabolism; D012633:Secretin; D014357:Trypsin / Q000378:metabolism
chemical_list: D012633:Secretin; D006632:Histamine; D002217:Carbachol; D002766:Cholecystokinin; D008049:Lipase; D000681:Amylases; D010447:Peptide Hydrolases; D014357:Trypsin
vernacular_title: Rol' intestinal'nykh gormonov v patogeneze éksperimental'nogo pankreatita.