Stimulation by estradiol benzoate of hepatic beta-hydroxy-beta-methylglutaryl coenzyme a reductase in normal and ovariectomized rats.
The effect of estradiol benzoate on beta-hydroxy-beta-methylglutaryl coenzyme A reductase activity and plasma cholesterol level has been studied in normal and ovariectomized rats. Daily administration of estradiol benzoate (25 microgram and 100 microgram) for 21 days resulted in a 1.7 and 2.5 fold increase in reductase activity in normal and ovariectomized rats, respectively. Plasma cholesterol levels were increased by 18% in normal rats and 38% in ovariectomized rats. The observed changes for the two treatment groups were similar even though the body weight for these groups were significantly different.
D000818:Animals; D001835:Body Weight; D002369:Castration; D002784:Cholesterol / Q000097:blood; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D008862:Microsomes, Liver / Q000201:enzymology; D010053:Ovary / Q000502:physiology*; D051381:Rats; D013268:Stimulation, Chemical
D004958:Estradiol; D002784:Cholesterol; D006903:Hydroxymethylglutaryl CoA Reductases