On gestagen treatment of advanced prostatic carcinoma.
Depostat treatment was found to reduce plasma testosterone and to have a gonadotrophin suppressive effect in males. In our study the clinical effect on prostatic cancer was, however, disappointing when compared to the well established effect of orchiectomy. The therapeutic failure of Depostat might be related to the incomplete suppression of plasma testosterone compared to that observed after orchiectomy.
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000628:therapy; D000368:Aged; D002369:Castration; D004341:Drug Evaluation; D005866:Gestonorone Caproate / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000628:therapy; D013739:Testosterone / Q000097:blood
D013739:Testosterone; D005866:Gestonorone Caproate