The temperature dependence of erythrocyte water diffusion permeability.
1. The activation energy of the diffusion water exchange in red blood cells increases with temperature. 2. Fetal blood has a higher activation energy for diffusion water exchange than adult blood. 3. Treatment of red cells with p-chloromercuribenzoate alters the activation energy and apparently allows a lipid and a protein pore pathway to be resolved. The permeability and activation energy of the treated cells is in the range found for lipid membranes; and the difference between treated and untreated cells, the "protein" pathway, has a diffusion activation energy comparable with that of free water. 4. A resolution of the discrepancies between the NMR methods of measuring diffusion water exchange is suggested.
D000328:Adult; D002452:Cell Count; D002463:Cell Membrane Permeability; D002648:Child; D002729:Chloromercuribenzoates / Q000494:pharmacology; D004058:Diffusion; D004912:Erythrocytes / Q000166:cytology / Q000378:metabolism*; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D006801:Humans; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism; D009136:Muscular Dystrophies / Q000097:blood; D011247:Pregnancy; D013696:Temperature; D013816:Thermodynamics; D014867:Water / Q000378:metabolism*
D002729:Chloromercuribenzoates; D008563:Membrane Lipids; D014867:Water