Substituted oxothiazolyl acetic acids as antiinflammatory agents.
Eight 2-arylimino-3-[/3-(3,4-dimethoxyphenyl) ethy1]-4-oxothiazol-5-yl-acetic acids were synthesized, characterized, and evaluated for their antiinflammatory and antiproteolytic properties. The toxocity of the compounds was reflected by their approximate LD50 values.
D000085:Acetates / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000633:toxicity; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D007928:Lethal Dose 50; D051381:Rats; D013844:Thiazoles / Q000494:pharmacology* / Q000633:toxicity
D000085:Acetates; D000893:Anti-Inflammatory Agents; D013844:Thiazoles; D002351:Carrageenan