[Antibodies against nicotine-like acetylcholine receptors of central nervous system and muscles in epileptics with IgA deficiency].
Anti-muscle nicotinic acetylcholine receptor (nAR) antibodies were sought in epileptic patients without clinical signs of myasthenia gravis. Low titers of such antibodies were found in 3 cases characterized by primary generalized seizures, IgA deficiency and HLA A1 and B8 antigens. These three patients also had anti-brain nAR antibodies. In the serum of one patient with myasthenia gravis, anti-brain nAR antibodies were also detected. The titer was low despite a high titer of anti-muscle nAR antibodies. This may reflect the fact that the immune reaction in the three epileptic patients is primarily directed against the brain nAR.
D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000032:analysis*; D002490:Central Nervous System; D002648:Child; D004827:Epilepsy / Q000276:immunology*; D005260:Female; D006648:Histocompatibility; D006801:Humans; D017098:IgA Deficiency; D008297:Male; D009132:Muscles; D009157:Myasthenia Gravis / Q000276:immunology; D011950:Receptors, Cholinergic; D011978:Receptors, Nicotinic
D001323:Autoantibodies; D011950:Receptors, Cholinergic; D011978:Receptors, Nicotinic
Antikörper gegen nicotinartige Acetylcholinrezeptoren des Zentralnervensystems und der Muskulatur bei Epileptikern mit IgA-Mangel.