Arsenic and cancer: effects of joint administration of arsenite and selenite on the genesis of mammary adenocarcinoma in inbred female C3H/St mice.
The joint administration of 2 ppm of arsenic as arsenite and of 2 ppm of selenium as selenite in the drinking water of inbred female C3H/St mice increases the incidence of spontaneous mammary adenocarcinoma significantly over the simultaneous controls and animals receiving 2 ppm As as arsenite or 2 ppm Se as selenite alone, indicating that arsenic abolishes the anticarcinogenic effect of selenium. Arsenite caused a significant increase of the tumor growth rates and raised the incidence of multiple tumors. The tumor growth rates in the As-Se group were also increased, but the incidence of multiple tumors was lower than in the 2 ppm As group.
D000230:Adenocarcinoma / Q000139:chemically induced*; D000818:Animals; D001151:Arsenic / Q000378:metabolism / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D004347:Drug Interactions; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced*; D051379:Mice; D008809:Mice, Inbred C3H; D012643:Selenium / Q000378:metabolism / Q000494:pharmacology*
D012643:Selenium; D001151:Arsenic