Human neuroblastoma serially transplanted in nude mice and metastases.
A human neuroblastoma from a female patient was directly transplanted into nude mice and serial transplantation was established. Histology of the transplanted tumor was almost the same as that of the patient. During serial transplantation, a high frequency of metastasis to distant organs such as ovaries, lymph node and cerebrum was observed, especially in the ovaries where the metastatic rate reached to 66%. Regarding the distribution of organs involved, there is close similarity between that in the patient with neuroblastoma and tumor-bearing mice. This transplantable human neuroblastoma provided a unique research tool for studies on its morphological and biological nature, including metastasis.
D000818:Animals; D001932:Brain Neoplasms / Q000473:pathology; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009362:Neoplasm Metastasis / Q000473:pathology; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000473:pathology; D009447:Neuroblastoma / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000473:pathology; D014183:Transplantation, Heterologous; D014185:Transplantation, Isogeneic