Urinary excretion of aflatoxin M1 after administration of aflatoxin B1 in sucrose- or starch-rich diets.
1. Male Sprague--Dawley rats were given 630 g/kg sucrose or starch with 2 mg/kg aflatoxin b1 for periods of 75, 145 and 200 d, and the 24 h urinary excretion of aflatoxin M1 was measured. 2. Less aflatoxin M1 was excreted by the rats fed on the sucrose-rich diet compared to those fed on the starch-rich diet. This difference was especially marked when expressed per g metabolizing tissue. 3. It is concluded that sucrose probably decreases the activity of aflatoxin B1 metabolism in a similar way to its previously found effect on the drug-metabolizing enzyme.
D000348:Aflatoxins / Q000378:metabolism* / Q000652:urine; D000818:Animals; D004032:Diet; D008297:Male; D051381:Rats; D013213:Starch; D013395:Sucrose
D000348:Aflatoxins; D013395:Sucrose; D013213:Starch