Sex differences in plasma half-life of dextrorphan in rats administered dextromethorphan.
Male and female rats exhibited striking differences in their ability to metabolize dextromethorphan. Upon oral administration of this drug, the plasma half-life of dextrorphan, a major biotransformation product formed by O-demethylation, was 40 min in the female rat and 18.5 min in the male.
D000818:Animals; D003915:Dextromethorphan / Q000378:metabolism*; D003917:Dextrorphan / Q000097:blood*; D005260:Female; D006207:Half-Life; D007981:Levorphanol / Q000031:analogs & derivatives*; D008297:Male; D009019:Morphinans / Q000097:blood*; D051381:Rats; D012737:Sex Factors
D009019:Morphinans; D003917:Dextrorphan; D007981:Levorphanol; D003915:Dextromethorphan