[Effect of pharmacologic substances on the dominance-submission relationship in a pair of rats].
The effect of neuroleptics (chlorpromazine, trifluoperazine, haloperidol), antidepressants (amitryptyline, imipramine), tranquilizers (diazepam, chlordiazepoxide, benactyzine) and stimulant d-amphetamine on the domination and subordination relations formed as a result of competitive behaviour in a pair of rats was studied. The drugs in question proved to violate the set relations of domination and subordination weakening the attacking ability of dominating rats and strengthening the defensability of the subordinate ones. With increase of antidepressants dosage received by a subordinate rat its competing ability becomes enhanced too; this may cause a change in domination.
D000639:Amitriptyline / Q000494:pharmacology; D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001535:Benactyzine / Q000494:pharmacology; D002707:Chlordiazepoxide / Q000494:pharmacology; D002746:Chlorpromazine / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology; D007099:Imipramine / Q000494:pharmacology; D008297:Male; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D012930:Social Dominance; D014268:Trifluoperazine / Q000494:pharmacology
D011619:Psychotropic Drugs; D000639:Amitriptyline; D014268:Trifluoperazine; D001535:Benactyzine; D002707:Chlordiazepoxide; D000661:Amphetamine; D006220:Haloperidol; D007099:Imipramine; D003975:Diazepam; D002746:Chlorpromazine
Vliianie farmakologicheskikh veshchestv na otnosheniia dominirovaniia i podchineniia v pare krys.