Stimulation of L-ornithine and S-adenosyl-L-methionine decarboxylases by beta-(p-chlorophenyl)-gamma-aminobutyric acid in mouse tissues.
Injections of beta-(p--chlorophenyl)-gamma-aminobutyric acid caused a monophasic stimulation of the activity of neural L-ornithine decarboxylase, to reach a maximum of 9-fold compared with the control values 3 h after treatment. Stimulation of hepatic L-ornithine decarboxylase was biphasic, the activity reaching its first peak, 48-fold compared with the control values, similarly at about 3 h after administration, and returning to its initial level by 4 h, and rising to a second peak, about one-third of the magnitude of the first, about 25 h after the injection. The effect in the adrenal gland of the mouse was multiphasic, reaching its maximum, 94-fold enzyme activity compared with the control values, 7--8 h after treatment. There were also marked fluctuations in the activity of S-adenosyl-L-methionine decarboxylase in the tissues examined.
D012437:Adenosylmethionine Decarboxylase / Q000378:metabolism*; D000311:Adrenal Glands / Q000201:enzymology*; D000613:Aminobutyrates / Q000494:pharmacology*; D000818:Animals; D001418:Baclofen / Q000494:pharmacology*; D001921:Brain / Q000201:enzymology*; D002262:Carboxy-Lyases / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D008297:Male; D051379:Mice; D009955:Ornithine Decarboxylase / Q000378:metabolism*; D013268:Stimulation, Chemical
D000613:Aminobutyrates; D002262:Carboxy-Lyases; D009955:Ornithine Decarboxylase; D012437:Adenosylmethionine Decarboxylase; D001418:Baclofen