title: Metabolism of 3-(2', 4', 5'-triethoxybenzoyl) propionic acid, a new biliary smooth muscle relaxant with choleretic activity. II. Metabolism after repeated dosing in rats, in relation to choleretic activity.
abstract: 1. Accumulation and possible induction in the metabolism of triethoxybenzoylpropionate were studied in rats in relation to the choleretic effect of the drug. Daily oral administration of [14 C] triethoxybenzoylpropionate showed no accumulation of drug or metabolites. Pre-treatment of rats with the drug did not induce its own metabolism or the metabolism of aminopyrine, p-nitroanisole, hexobarbital or zoxazolamine. 2. Choleresis in rats induced by triethoxybenzoylpropionate resulted from enhanced formation of the bile acid-independent fraction of canalicular origin, presumably mediated by the increased transfer of sodium into the canaliculi. This was not altered by repeated pre-treatment with the drug, in accordance with the metabolic findings.
mesh_terms: D000818:Animals; D002756:Cholagogues and Choleretics; D004790:Enzyme Induction / Q000187:drug effects; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism; D008297:Male; D010276:Parasympatholytics / Q000378:metabolism* / Q000494:pharmacology; D011422:Propionates / Q000378:metabolism* / Q000494:pharmacology; D051381:Rats; D013997:Time Factors
chemical_list: D002756:Cholagogues and Choleretics; D010276:Parasympatholytics; D011422:Propionates