title: Correlation of chemical structure and taste in the cyclamate series and the steric nature of the chemoreceptor site.
abstract: The requirements of compounds in the cyclamate series for sweet taste stimulation are: synclinal conformation between NH and SO in the aminosulphonate group, length less than 0.7 nm of the group on the nitrogen, and hydrophobic character of the latter group. A hypothetical receptor site for these compounds should have a spatial barrier at a distance of about 0.7 nm from the nitrogen interaction point with the receptor site, and a hydrophobic interaction area between the nitrogen interaction point and the barrier.
mesh_terms: D055598:Chemical Phenomena; D002621:Chemistry; D003494:Cyclamates / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D008958:Models, Molecular; D009584:Nitrogen; D013329:Structure-Activity Relationship; D013649:Taste; D013650:Taste Buds / Q000378:metabolism*
chemical_list: D003494:Cyclamates; D009584:Nitrogen