Bile acid and cholesterol excretion in the pregnant guinea pig: studies on the hypercholesterolemia of pregnancy.
The relationship of bile acid and cholesterol excretion to changes in plasma cholesterol during pregnancy were studied in guinea pigs. Plasma cholesterol level increased in the first trimester of pregnancy, reached to a peak during the second trimester and decreased in the third trimester reaching the lowest level at one week prior to parturition. Cholesterol level returned to the control level after parturition. Plasma triglyceride level followed a similar trend attaining peak values at second trimester and gradually returned to the control level at the third trimester of pregnancy. Bile acid and total sterol excretion were significantly higher in guinea pigs during the last phase of pregnanccy while they remained unchanged during early stage of pregnancy.
D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism*; D001835:Body Weight; D002784:Cholesterol / Q000097:blood / Q000378:metabolism*; D005243:Feces / Q000737:chemistry; D005260:Female; D005865:Gestational Age; D006168:Guinea Pigs; D006937:Hypercholesterolemia / Q000378:metabolism*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism*; D011270:Pregnancy, Animal; D013261:Sterols / Q000378:metabolism; D014280:Triglycerides / Q000097:blood
D001647:Bile Acids and Salts; D013261:Sterols; D014280:Triglycerides; D002784:Cholesterol