Influence of ethoxyquin on the utilization of selenium by the chick.
Experiments showed that commonly used concentrations of dietary ethoxyquin (6-ethoxy-2,2,4-trimethyl-1,2-dihydroxyquinoline) spare the selenium requirement of the vitamin E-deficient chick according to the following function: log Y = -0.0011X - 0.7741, where Y = Se requirement (ppm) and X = dietary ethoxyquin (ppm). The basis of the sparing effect appeared to be metabolic; (a) ethoxyquin was effective in alleviating exudative diathesis when fed (physiologically and chronologically) separately from selenium, and (b) ethoxyquin was effective in promoting increases in the plasma of the selenium-containing enzyme, glutathione peroxidase.
D000818:Animals; D002645:Chickens / Q000378:metabolism*; D005015:Ethoxyquin / Q000008:administration & dosage / Q000494:pharmacology*; D005979:Glutathione Peroxidase / Q000097:blood; D011201:Poultry Diseases / Q000378:metabolism / Q000517:prevention & control; D011804:Quinolines / Q000494:pharmacology*; D012643:Selenium / Q000008:administration & dosage / Q000172:deficiency / Q000378:metabolism*; D014810:Vitamin E / Q000008:administration & dosage / Q000097:blood; D014811:Vitamin E Deficiency / Q000378:metabolism / Q000517:prevention & control / Q000662:veterinary
D011804:Quinolines; D014810:Vitamin E; D005015:Ethoxyquin; D005979:Glutathione Peroxidase; D012643:Selenium