Peripheral handling of angiotensin II and blood pressure control in hypertensive patients with unilateral and bilateral renal disease.
PRA, AII CR, AII E and cardiac output have been measured in 9 normals and in 22 hypertensives: 8 with URD, 12 with BRD and 2 with MHY. PRA, as well as AII E, shows the highest values in BRD and MHY patients. AII CR is directly correlated with blood pressure levels in URD and BRD patients (p less than 0.05 and p less than 0.001, respectively). A significant positive correlation is found between AII E and TPR (within each group of patients and among all subjects) and between PRA and TPR within the hypertensive patients. These data suggest that peripheral handling of AII is involved in the control of blood pressure in the patients studied.
D000804:Angiotensin II / Q000097:blood*; D001794:Blood Pressure; D002302:Cardiac Output; D006801:Humans; D006974:Hypertension, Malignant / Q000097:blood / Q000503:physiopathology; D006977:Hypertension, Renal / Q000097:blood* / Q000503:physiopathology
D000804:Angiotensin II