[Relationship between prolactin and serum proteins. 1. Protein-bound hormone protected from biodegradation in the kidneys].
The authors studied binding of prolactin labeled with 125I in the blood of rats and lactating goats. Not over 20% of the hormone was bound in vitro the first 5 to 10 min of incubation with the blood serum, and a complex with molecular weight of 200 000 appeared which was similar to that formed in vivo. With a longer incubation 125I-prolactin was bound in serum macroglobulin fraction; this was not observed in vivo. Blood protein-bound prolactin retained its immunological activity. Monomeric hormone was absorbed in the kidneys and the mammary glands, with the subsequent rapid degrading. Blood protein-bound prolactin was not absorbed in the kidneys, and was present in the mammary glands in small amounts only.
D000818:Animals; D001711:Biotransformation; D002417:Cattle; D005260:Female; D006041:Goats; D006728:Hormones / Q000378:metabolism; D066298:In Vitro Techniques; D007457:Iodine Radioisotopes; D007553:Isotope Labeling; D007668:Kidney / Q000378:metabolism*; D008321:Mammary Glands, Animal / Q000378:metabolism; D011388:Prolactin / Q000378:metabolism*; D011485:Protein Binding; D051381:Rats; D012709:Serum Albumin / Q000378:metabolism*; D012712:Serum Globulins / Q000378:metabolism*; D012756:Sheep
D006728:Hormones; D007457:Iodine Radioisotopes; D012709:Serum Albumin; D012712:Serum Globulins; D011388:Prolactin
Vzaimodeĭstvie prolaktina s syvorotochnymi belkami. 1. Sviazannyĭ s belkom gormon zashchishchen ot degradatsii v pochkakh.