Prostaglandin D2, another renal prostaglandin?
Prostaglandin (PG) D2 was biosynthesized by rabbit renal papillae incubates in vitro. Quantification of the renal prostaglandins by gas chromatography-mass spectroscopy demonstrated that the concentration of PGD2 generated by renal papillae was 1/6 to 1/10 the amount of PGE2 or about 1microgram/g tissue/30 min. Infusion of the sodium salt of PGD2 into the renal artery of the dog produced a dose related increase in renal blood flow and urine flow, free water clearance, sodium excretion and potassium excretion without changes in systemic hemodynamics. At low doses PGD2 increased renal blood flow to all cortical zones. Higher concentrations of PGD2 produced a shift in the intrarenal distribution of blood flow toward the juxtamedullary nephrons.
D000818:Animals; D002849:Chromatography, Gas; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D007668:Kidney / Q000098:blood supply / Q000187:drug effects; D007679:Kidney Medulla / Q000378:metabolism*; D013058:Mass Spectrometry; D011188:Potassium / Q000652:urine; D011457:Prostaglandins D / Q000008:administration & dosage / Q000032:analysis; D011458:Prostaglandins E / Q000032:analysis; D011817:Rabbits; D012077:Renal Artery; D012964:Sodium / Q000652:urine; D013997:Time Factors
D011457:Prostaglandins D; D011458:Prostaglandins E; D012964:Sodium; D011188:Potassium