[Lipid extraction from blood plasma and the subsequent administration of the autologous delipidized plasma as a possible agent for treating atherosclerosis (an experimental study)].
A method for the delipidization of blood plasma of rabbits and dogs with diethyl ether with its subsequent reinfusion into the animal's body is described. Triglycerides and cholesterol were mainly extracted from blood plasma, and only 1/3 of phospholipids. In dog experiments the plasma delipidization procedures led to a decrease of the cholesterol content in the overall fraction of atherogenic lipoproteins of low and very low density and an increase of the cholesterol content in antiatherogenic lipoproteins of high density. The lipoextraction procedures are harmless and may be employed for reducing the blood lipid level.
D000818:Animals; D001161:Arteriosclerosis / Q000097:blood / Q000628:therapy*; D001804:Blood Transfusion, Autologous / Q000379:methods*; D002784:Cholesterol / Q000097:blood; D004036:Diet, Atherogenic; D004285:Dogs; D017707:Erythrocyte Transfusion; D008055:Lipids / Q000302:isolation & purification*; D008297:Male; D010949:Plasma; D011817:Rabbits; D014280:Triglycerides / Q000097:blood
D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol
Ekstraktsiia lipidov iz plazmy krovi i posleduiushchee vvedenie v organizm sobstvennoĭ delipidirovannoĭ plazmy kak vozmozhnoe sredstyo lecheniia ateroskleroza (éksperimental'noe issledovanie).