Aurantinin, a new antibiotic of bacterial origin.
A new polyene class antibiotic, aurantinin (KM-214), was isolated from the fermentation broth of Bacillus aurantinus MASUMA and OMURA sp. nov. The substance is a conjugated triene with a molecular weight of 618 and molecular formula C35H54O9, and melts at 139 approximately 140 degrees C. The antibiotic is active in vitro against Gram-positive bacteria, but not against yeast and fungi.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000096:biosynthesis / Q000494:pharmacology*; D001407:Bacillus / Q000254:growth & development / Q000378:metabolism / Q000648:ultrastructure; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D051379:Mice; D011090:Polyenes / Q000032:analysis / Q000096:biosynthesis / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D011090:Polyenes