[Plasma 25-hydroxycholecalciferol after daily vitamin D administration in comparison with massive single-dose prophylaxis (author's transl)].
The effect of daily administration of 1200 IU vitamin D3 was compared with the response to a single oral dose of 200,000 IU in 21 young infants by determination of the plasma 25-OHCC levels. After about one week the mean value recorded in group 1 was 27 +/- 13 ng/ml; the corresponding value in group 2 was 127 +/- 78.4 ng/ml. At the second control examination about one month subsequently, the mean values were 61 +/- 26.2 ng/ml and 104 +/- 69.0 ng/ml respectively. The wide range of values found in the single-dose group clearly demonstrates the advantage of daily vitamin D administration for routine prophylaxis against rickets in infancy.
D000284:Administration, Oral; D000367:Age Factors; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006887:Hydroxycholecalciferols / Q000097:blood*; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011863:Radioimmunoassay; D012279:Rickets / Q000517:prevention & control; D014807:Vitamin D / Q000008:administration & dosage*
D006887:Hydroxycholecalciferols; D014807:Vitamin D
Plasmaspiegel des 25-Hydroxycholecalciferols nach Tages- und "Stossprophylaxe" mit Vitamin D.