title: [Adrenosensitivity of isolated rat organs after a change in their noradrenaline content].
abstract: The 30-day dynamics of noradrenaline contents after a single administration of guanitidine (50 mg/kg) was similar in the heart and small intestine but different in the vas deferens. The decrease of the noradrenaline content in the small intestine and vas deferens duct was followed by an increase of their adrenosensitivity, and the restoration of noradrenaline level--by a decrease of the adrenosensitivity, which reveals an invert relationship between these parameters (the correlation coefficient for small intestine being 0.78 and for vas deferens duct--0.61). The role of the catecholamine level near the adrenoreceptors in regulation of the adrenosensitivity of effectors is discussed.
mesh_terms: D000311:Adrenal Glands / Q000502:physiology; D000818:Animals; D006145:Guanethidine / Q000494:pharmacology*; D006321:Heart / Q000502:physiology; D007421:Intestine, Small / Q000502:physiology; D008297:Male; D009638:Norepinephrine / Q000032:analysis / Q000494:pharmacology / Q000502:physiology*; D009928:Organ Specificity; D051381:Rats; D011941:Receptors, Adrenergic / Q000502:physiology*; D014649:Vas Deferens / Q000502:physiology
chemical_list: D011941:Receptors, Adrenergic; D009638:Norepinephrine; D006145:Guanethidine
vernacular_title: Adrenochuvstvitel'nost' izolirovannykh organov krys pri izmenenii v nikh soderzhaniia noradrenalina.