[Hypertrophy and hyperplasia of hyperactive thyroid cells: hormonal secretion is independent of apical phagocytosis (author's transl)].
Hyperactive thyroid are obtained by daily injections of TSH 15 I.U. I.M. in dogs for 8 days. The high secretion rate of butanol-extractible iodide (BE125I) in vitro by prelabelled slices is not related to apical phagocytosis (lack of apical pseudopods and intracellular colloid droplets, insensitivity to cytochalasin, vinblastine, vincristine and colchicine). The secretory process is insensitive to metabolic inhibitors, decreases exponentially with the temperature without step transition and could be related to micropinocytosis.
D000818:Animals; D003571:Cytochalasin B / Q000494:pharmacology; D004285:Dogs; D006965:Hyperplasia; D006984:Hypertrophy; D010587:Phagocytosis; D010873:Pinocytosis; D013961:Thyroid Gland / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D013963:Thyroid Hormones / Q000378:metabolism*; D013972:Thyrotropin / Q000494:pharmacology
D013963:Thyroid Hormones; D003571:Cytochalasin B; D013972:Thyrotropin
Hypertrophie et hyperplasie des cellules thyroïdiennes hyperactives: la sécrétion hormonale est indépendante de la phagocytose apicale.