[Kidney preservation by hypothermic storage in Collins and Sacks solutions: the influence of 0-30 min of warm ischemia on the available preservation period (author's transl)].
123 kidneys of mongrel dogs were stored under hypothermic conditions in Collins or Sacks solutions for 12 up to 72 h and then transplanted. Before preservation the kidneys were subdued to 0-30 min warm ischemia. Kidney function after transplantation was measured by PAH-and inulin-clearances. Successful 24 h preservation was likewise possible with Collins and Sacks solutions if there was not any warm ischemia. Kidney function was reduced by the length of preservation, according to the formula; y = 166.02 . e-0,125x (y = PAH-clearance and x = preservation time). With both solutions the most attainable preservation time after 15 min warm ischemia was only 12 h, longer preservation time or ischemic periods were not tolerable. However, the function of the ischemically damaged organ was significantly better preserved by Sacks solution in comparison with Collins solution-although the preservation period could not be extended by this solution. Therefore, as far as human kidney preservation is concerned, Collins solution should be replaced by Sacks solution.
D000818:Animals; D004285:Dogs; D007511:Ischemia; D007668:Kidney / Q000098:blood supply; D009926:Organ Preservation / Q000379:methods*; D012034:Refrigeration; D012996:Solutions; D013696:Temperature; D013997:Time Factors; D014021:Tissue Preservation / Q000379:methods*
D012996:Solutions
Nierenkonservierung durch hypotherme Lagerung nach Collins und Sacks: Der Einfluss von 0-30 min warmer Ischämie auf die erreichbare Konservierungszeit.