Influence of iron on Corynebacterium renale-induced pyelonephritis in a rat experimental model.
Growth of Corynebacterium renale in vitro on low-iron medium (1.34 micron) was only slightly less than that on high-iron media (7.16 and 9.85 micron). However, studies on C. renale-induced pyelonephritis using the rat as an experimental model revealed that C. renale cultivated in high-iron media was capable of producing pyelonephritis, but when grown on low-iron medium, these bacteria were noninfective. This apparent avirulence of the bacteria cultivated on low levels of iron could be reversed by injecting the rats intramuscularly with ferric ammonium citrate.
D000818:Animals; D003352:Corynebacterium / Q000254:growth & development; D003354:Corynebacterium Infections / Q000473:pathology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005290:Ferric Compounds / Q000494:pharmacology; D007501:Iron / Q000494:pharmacology*; D008297:Male; D011704:Pyelonephritis / Q000209:etiology*; D051381:Rats
D005290:Ferric Compounds; D007501:Iron