title: The synthesis and opiate activity of human beta-endorphin analogs. Substituted at residue positions 27 and 31.
abstract: Four analogs of human beta-endorphin have been synthesized and their opiate activities have been determined. One of the analogs, [27-phenylalanine, 31-glycine]-betah-endorphin, was shown to possess an analgesic potency greater than that of the natural peptide.
mesh_terms: D000595:Amino Acid Sequence; D000700:Analgesics; D000818:Animals; D001681:Biological Assay; D004723:Endorphins / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology; D006168:Guinea Pigs; D051379:Mice
chemical_list: D000700:Analgesics; D004723:Endorphins