title: Effect of vitamin E and ozone on pentane and ethane expired by rats.
abstract: Pentane and ethane, which arise during lipid peroxidation in vivo, were measured by gas chromatography in breath samples of rats fed for 8 weeks a vitamin E-deficient diet to which had been added 0, 11, or 40 IU vitamin E acetate per kg. Further lipid peroxidation was induced by exposure of individual rats to 1 ppm ozone for 60 min. Nonparametric statistical analysis of the data for pentane expired before exposure of rats to ozone gave alpha values (alpha = 2P) of 0.006 when the O vitamin E group was compared with either of the vitamin E-supplemented groups. For ethane, comparison of the O vitamin E group with the groups supplemented with 11 and 40 IU vitamin E/kg of diet were 0.0294 and 0.0080, respectively. Alpha values less than .05 were considered significant. After a 60-min exposure of rats to 1 ppm ozone, the paired t-test showed pentane to be significantly (P less than .005) increased in only the rats fed the vitamin E-deficient diet.
mesh_terms: D000818:Animals; D001944:Breath Tests; D002849:Chromatography, Gas / Q000295:instrumentation; D050356:Lipid Metabolism; D008297:Male; D010126:Ozone / Q000494:pharmacology*; D010420:Pentanes / Q000378:metabolism*; D010545:Peroxides / Q000378:metabolism; D051381:Rats; D014810:Vitamin E / Q000494:pharmacology*
chemical_list: D010420:Pentanes; D010545:Peroxides; D014810:Vitamin E; D010126:Ozone