[Blastomogenic activity of substance complexes that leached out of rubbers into food media].
The complex of agents migrating from low-dispersed soot resins PM-15 and PGM-33, injected in the stomach or applied onto the skin of mice C57Bl, showed an insignificant blastomogenic activity. Most sensitive to their effect were the tissues of organs at the site of injection (proventricular papillomas in 8.3% of cases, skin papillomas in 12.5%), in the lung (adenomas in 12.5%) and in the pancreas (fibroadenoma in 4.2%). In the negative control groups of animals no tumors of such localization were noted. The whole complex of substances migrating from resins renders the blastomogenic effect, i. e. there is a combined action with an enhancement of blastomogenic effect.
D000818:Animals; D002244:Carbon; D002273:Carcinogens; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D005511:Food Handling; D051379:Mice; D008810:Mice, Inbred C57BL; D009374:Neoplasms, Experimental / Q000139:chemically induced; D012408:Rubber / Q000633:toxicity*; D012867:Skin / Q000187:drug effects; D013270:Stomach / Q000187:drug effects; D013997:Time Factors
D002273:Carcinogens; D004338:Drug Combinations; D002244:Carbon; D012408:Rubber
Blastomogennaia aktivnost' kompleksov veshchestv, vymyvaemykh v pishchevye sredy iz rezin.