Anti-lea as an autoantibody in the serum of le(a - b+) individual.
The first example of anti-Lea, as an autoantibody, in the serum of a phenotypically Le(a-b+) individual is described. The patient is a 55 year old male with squamous cell carcinoma of the esophagus. His saliva contains Lea, Leb and H substances, and inhibits the hemagglutinating activity of his serum anti-Lea. The Leb antigen content of his red blood cells is approximately half that of control Le(a-b+) red blood cells. The patient's disease process may be responsible for the development of this unexpected autoantibody.
D000017:ABO Blood-Group System; D001323:Autoantibodies / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000276:immunology; D004938:Esophageal Neoplasms / Q000276:immunology; D006801:Humans; D037102:Lectins; D007983:Lewis Blood Group Antigens; D008297:Male; D008875:Middle Aged; D012463:Saliva / Q000276:immunology
D000017:ABO Blood-Group System; D001323:Autoantibodies; D037102:Lectins; D007983:Lewis Blood Group Antigens