[Action of the calciumantagonistic compound gallopamile on sinus node, atrioventricular and intraventricular conduction (author's transl)].
The influence of the calciumantagonistic agent Gallopamile (D 600) on cardiac conduction and sinus node function was studied by using His bundle recordings and atrial stimulation in 13 patients with normal sinus rhythm. Intravenous administration of a single dose of 4 mg produced a significant increase in the atrioventricular conduction time by 30 %. On atrial stimulation second degree a-v block occurred at lower stimulation rates in all patients after Gallopamile. The impulse propagation in atrial tissue and within the His-Purkinje system was not affected, even in patients with diseased conduction system. There was an impairment in sinus node automaticity, the sinus node recovery time was increased by 58 % of the control value.
D000328:Adult; D000368:Aged; D001146:Arrhythmia, Sinus / Q000188:drug therapy*; D001283:Atrioventricular Node / Q000187:drug effects; D002036:Bundle of His / Q000187:drug effects; D002118:Calcium / Q000037:antagonists & inhibitors; D002304:Cardiac Pacing, Artificial; D004562:Electrocardiography; D005260:Female; D005711:Gallopamil / Q000627:therapeutic use*; D006327:Heart Block / Q000139:chemically induced / Q000188:drug therapy; D006329:Heart Conduction System / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects; D012849:Sinoatrial Node / Q000187:drug effects; D014700:Verapamil / Q000031:analogs & derivatives*
D005711:Gallopamil; D014700:Verapamil; D002118:Calcium
Die Wirkung von Gallopamil (D 600) auf die intrakardiale Erregungsleitung und Sinusknotenautomatie beim Menschen.