title: Megaloblastic erythropoiesis and tissue depletion of folic acid in the cat.
abstract: Dietary requirement for folic acid was shown in the cat. Folic acid deficiency was produced by feeding young cats a deficient diet (0.125 mg of total folate/kg of dry weight by analysis) for 22 weeks. The folic acid-deficient cats grew normally, but had reduced plasma, red blood cell, and liver folate concentrations in comparison with those concentrations in cats fed a control diet (1.36 mg of total folate/kg).. Urinary excretion of formiminoglutamic acid was increased in all deficient diet cats 24 hours after L-histidine injection. Erythroblasts in bone marrow smears from folic acid-deficient cats were megaloblastic; they showed abnormal nuclear chromatin patterns and had nuclear-cytoplasmic asynchronism.
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000473:pathology; D002371:Cat Diseases / Q000378:metabolism* / Q000473:pathology; D002415:Cats; D004912:Erythrocytes / Q000378:metabolism; D004920:Erythropoiesis; D005492:Folic Acid / Q000097:blood; D005494:Folic Acid Deficiency / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D008099:Liver / Q000378:metabolism
chemical_list: D005492:Folic Acid