Choline acetyltransferase activity in postganglionic parasympathetic nerves after "pharmacological decentralization".
The ganglion blocking drug chlorisondamine given frequently and in gradually increasing doses over a period of time to adult rats causes the activity of choline acetyltransferase to fall in the postganglionic parasympathetic nerves of parotid glands. Such a "pharmacologically" decentralized gland was also found to have lost weight and to have developed a supersensitivity to chemical stimuli. All these phenomena are thought to be consequences of loss or reduction of secretory impulses from the central nervous system due to impaired ganglionic transmission.
D000818:Animals; D001338:Autonomic Fibers, Postganglionic / Q000201:enzymology*; D001835:Body Weight / Q000187:drug effects; D002714:Chlorisondamine / Q000008:administration & dosage / Q000494:pharmacology*; D002795:Choline O-Acetyltransferase / Q000378:metabolism*; D002799:Cholinergic Fibers / Q000201:enzymology; D009929:Organ Size / Q000187:drug effects; D010306:Parotid Gland / Q000294:innervation; D051381:Rats; D013361:Sublingual Gland / Q000294:innervation; D013363:Submandibular Gland / Q000294:innervation; D013997:Time Factors
D002795:Choline O-Acetyltransferase; D002714:Chlorisondamine