Prostatic cellular changes after injection of cadmium and lead into rat prostate.
Forty male rats were divided into four groups. Group I served as control. Group II received 1 mg. lead injected into the prostate; Group III received 1 mg. cadmium chloride; and Group IV received 0.5 mg. lead acetate and 0.5 mg. cadmium chloride. Results indicated that lead caused stone formation in the bladder and calcification of both bladder and prostate; cadmium caused reduction in size and weight of prostate, and histological observation showed marked atrophy of the gland, cuboidal epithelium, and squamous metaplasia in the acini of the prostate; there was no synergistic effect of lead acetate and cadmium chloride when combined at the level administered to Group IV.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002104:Cadmium / Q000097:blood / Q000494:pharmacology*; D002122:Calcium Chloride / Q000494:pharmacology; D007854:Lead / Q000097:blood / Q000494:pharmacology*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011467:Prostate / Q000033:anatomy & histology / Q000166:cytology / Q000187:drug effects*; D051381:Rats; D013737:Testis / Q000187:drug effects; D001743:Urinary Bladder / Q000187:drug effects
D002104:Cadmium; D007854:Lead; D002122:Calcium Chloride