title: In vitro antiplaque properties of a series of alkyl bis(biguanides).
abstract: A series of eight alkyl bis(biguanide) analogues of alexidine, N,N''''-1,6-hexanediyl bis[N'-(2-ethylhexyl)imidodicarbonimidic diamide] (1), was prepared. Five of these analogues constituted a series isolipophilic with 1 but with varying bridge length between biguanide moieties. The compounds were evaluated in vitro for antibacterial and antiplaque properties against Streptococcus mutans, Actinomyces viscosus, and Actinomyces naesludii. One analogue, N N,''''-1,6-hexanediyl bis[N'(n-octyl)imidodicarbonimidic diamide], appeared to be more effective than either 1 or chlorhexidine against this spectrum of dental plaque forming microorganisms.
mesh_terms: D000190:Actinomyces / Q000187:drug effects; D001645:Biguanides / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D003773:Dental Plaque / Q000517:prevention & control*; D013295:Streptococcus mutans / Q000187:drug effects
chemical_list: D001645:Biguanides