title: Myofibroblasts and free silicon around breast implants.
abstract: Fibrous tissue capsules, from around silicone breast implants, were examined by light microscopy, and by transmission and scanning electron microscopy, the latter combined with energy dispersive X-ray analysis. Contractile fibroblasts (myofibroblasts) were found in most of these fibrous capsules, and especially in those recently formed or manipulated. The element silicon was positively identified by X-ray analysis in half the tissue specimens. This material was found only around gel-filled implants. In the specimens studied, the clinical hardness of the breast was unrelated to the presence of silicon in the capsule.
mesh_terms: D001940:Breast / Q000473:pathology / Q000601:surgery*; D005260:Female; D005347:Fibroblasts / Q000648:ultrastructure; D006801:Humans; D011183:Postoperative Complications / Q000473:pathology* / Q000517:prevention & control; D019736:Prostheses and Implants; D012825:Silicon / Q000032:analysis; D012828:Silicones; D013518:Surgery, Plastic; D014221:Triamcinolone / Q000008:administration & dosage
chemical_list: D012828:Silicones; D014221:Triamcinolone; D012825:Silicon