Experimental internal iliac artery embolization: evaluation of low viscosity silicone rubber, isobutyl 2-cyanoacrylate, and carbon microspheres.
The angiographic, morphologic, and histologic effects of carbon microspheres, isobutyl 2-cyanoacrylate (IBC), and low viscosity silicone rubber (LVSR) were compared. Carbon spheres did not effectively occlude the internal iliac artery, but resulted in small vessel occlusions leading to the most frequent complications. IBC was effective in causing occlusion but resulted in significant inflammatory changes within the thrombus and vessel wall. LVSR gave satisfactory occlusion without inciting vessel wass inflammatory reaction. Two of 4 animals developed a hind extremity paralysis. None of these materials is approved for general intravascular usage.
D000818:Animals; D002015:Bucrylate / Q000633:toxicity; D002244:Carbon / Q000633:toxicity; D002404:Catheterization; D003487:Cyanoacrylates / Q000633:toxicity; D004341:Drug Evaluation; D004621:Embolization, Therapeutic / Q000379:methods*; D005069:Evaluation Studies as Topic; D007083:Iliac Artery / Q000187:drug effects; D008722:Methods; D008863:Microspheres; D012826:Silicone Elastomers / Q000633:toxicity; D013552:Swine
D003487:Cyanoacrylates; D012826:Silicone Elastomers; D002015:Bucrylate; D002244:Carbon