title: Recessive male-determining genes.
abstract: The autosomal dominant gene polled (P) causes hornlessness in goats. Chromosomal females (XX) that are P/P homozygotes develop testes or ovotestes. Thus with respect to its testis-determining properties, P or a closely linked gene acts as an autosomal recessive. Polled intersex goats are H-Y+. This finding is consistent with the view that there may be a cluster of testis-determining H-Y genes on the Y chromosome, and that translocation of a subcritical portion of these genes may generate a recessive mode of sex determination.
mesh_terms: D000818:Animals; D012734:Disorders of Sex Development / Q000235:genetics* / Q000276:immunology; D005260:Female; D005796:Genes; D005808:Genes, Recessive; D008040:Genetic Linkage; D006041:Goats / Q000235:genetics*; D006182:H-Y Antigen / Q000235:genetics*; D008297:Male; D009154:Mutation; D012732:Sex Determination Analysis; D014178:Translocation, Genetic; D014998:Y Chromosome
chemical_list: D006182:H-Y Antigen