Synthesis and antiinflammatory activity of trisubstituted pyrimidines and triazines.
A series of mono-, bi-, and tricyclic pyrimidines and as-triazines was prepared and their antiinflammatory activity measured against carrageenan-induced edema in the rat. The more active analogues (ED50), including 4-pyri-dylpyrimidines 4a (38), 4b (47), and 4g (49) and 2-hydroxypyrimidine 8r (43), were then tested against adjuvant-induced edema in the rat. None was active in the adjuvant arthritis model.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D001169:Arthritis, Experimental / Q000188:drug therapy; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000627:therapeutic use; D051381:Rats; D013329:Structure-Activity Relationship; D014227:Triazines / Q000138:chemical synthesis* / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D011743:Pyrimidines; D014227:Triazines; D002351:Carrageenan