title: Percutaneous absorption in experimental epidermal proliferation.
abstract: Essential fatty acid deficiency (EFAD) results in epidermal hyperproliferation with acanthosis and hyperkeratosis. The EFAD hairless mouse has been used to study the percutaneous absorption of a 0.1% solution of 4-(14)C-hydrocortisone. In vitro absorption was increased significantly through EFAD compared with normal hairless mouse skin. This is further evidence for a defective skin barrier function in epidermal hyperproliferation.
mesh_terms: D000818:Animals; D005228:Fatty Acids, Essential / Q000172:deficiency; D006854:Hydrocortisone / Q000378:metabolism*; D008297:Male; D051379:Mice; D008819:Mice, Nude; D012867:Skin / Q000033:anatomy & histology; D012869:Skin Absorption; D012871:Skin Diseases / Q000209:etiology / Q000378:metabolism* / Q000473:pathology
chemical_list: D005228:Fatty Acids, Essential; D006854:Hydrocortisone