Taurine conjugation in metabolism of 3-phenoxybenzoic acid and the pyrethroid insecticide cypermethrin in mouse.
1. A substantial proportion of the radioactivity of an oral dose (1-20 mg/kg) of 3-phenoxy [14C] benzoic acid and the pyrethroid insecticide trans- and cis-[aryl-14C] cypermethrin (an alpha-cyano-3-phenoxybenzyl ester) is eliminated rapidly in urine of mice. 2. The major urinary metabolite of these compounds in two strains of mice is N-(3-phenoxybenzoyl)taurine. 3. Neither 3-phenoxybenzoic acid nor cypermethrin gives a taurine conjugate in rats. 4. Benzoic acid gives no taurine conjugate in mice.
D000818:Animals; D001565:Benzoates / Q000378:metabolism* / Q000652:urine; D008297:Male; D051379:Mice; D010647:Phenyl Ethers / Q000378:metabolism* / Q000652:urine; D011722:Pyrethrins / Q000378:metabolism* / Q000652:urine; D051381:Rats; D013045:Species Specificity; D013654:Taurine / Q000378:metabolism*
D001565:Benzoates; D010647:Phenyl Ethers; D011722:Pyrethrins; D013654:Taurine; C017618:3-phenoxybenzoic acid