title: [Model of disseminated intravascular coagulation].
abstract: Vascular-thrombocytic and plasma hemostasis was studied in dogs after blood loss (40--50 ml/kg weight) and subsequent hypervolemic (60--65 ml/kg weight) transfusion of homologous (from 3 donors) platelet and leukocyte rich in plasma. After a short phase of hypercoagulation all the tested dogs displayed hypocoagulation accompanied by a decrease in the count of platelets and a fall of their aggregation function, prolongation of bleeding time, diminution of capillary wall resistance, a decrease of plasma fibrinogen concentration and factor XIII activity, and by a rise of blood fibrinolytic activity. The data obtained show the development of the acute disseminated intravascular coagulation syndrome (DIC). DIC model is porposed on the basis of the results obtained.
mesh_terms: D000818:Animals; D001779:Blood Coagulation Factors / Q000032:analysis; D004195:Disease Models, Animal; D004211:Disseminated Intravascular Coagulation / Q000097:blood; D004285:Dogs; D008297:Male; D010973:Platelet Adhesiveness; D010974:Platelet Aggregation
chemical_list: D001779:Blood Coagulation Factors
vernacular_title: Model' disseminirovannogo vnutrisosudistogo svertyvaniia krovi.