Hospital treatment of congestive heart failure. Management according to hemodynamic profile.
Selection of therapy for subjects with acute congestive dardiac failure usually involves a choice among a diuretic, a vasodilator and an inotropic agent. Three principal questions are involved in the decision: (1) Is cardiac out normal or depressed? (2) Is blood pressure normal or depressed? (3) is regional myocardial ischemia present? Diuretics are safe and easy to administer, but they do not increase cardiac output or relieve hypoperfusion. Inotropic agents increase cardiac output but differ widely in their effects on blood pressure: selection of specific agents is influenced by their blood pressure effect. All inotropic agents, however, potentially aggravate regional myocardial ischemia. In ischemic heart failure, therefore, vasodilators which also increase cardiac output, may be chosen. Vasodilator administration is in turn limited by the decrease in arterial pressure which accompanies increasing infusion rate. When these three questions are considered in combination, an effective therapeutic regimen can be identified. Thus, congestion without hypoperfusion requires a diuretic if blood pressure is normal; and a vasodilator when blood pressure is increased. In the presence of congestion with hypoperfusion, a vasodilator is employed if blood pressure is normal; and a positive inotropic drug when blood pressure is depressed.
D001794:Blood Pressure / Q000187:drug effects; D002196:Capillaries / Q000503:physiopathology; D002302:Cardiac Output / Q000187:drug effects; D002395:Catecholamines / Q000494:pharmacology; D003327:Coronary Disease / Q000503:physiopathology; D004071:Digitalis Glycosides / Q000494:pharmacology; D004232:Diuretics / Q000494:pharmacology; D006333:Heart Failure / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D006439:Hemodynamics; D006760:Hospitalization; D006801:Humans; D009020:Morphine / Q000494:pharmacology; D009200:Myocardial Contraction / Q000187:drug effects; D011654:Pulmonary Edema / Q000209:etiology; D014665:Vasodilator Agents / Q000494:pharmacology
D002395:Catecholamines; D004071:Digitalis Glycosides; D004232:Diuretics; D014665:Vasodilator Agents; D009020:Morphine