Types of endocrine cells in the human colon and rectum.
At least four types of endocrine-like cells have been detected histochemically in the mucosa of the human colon and rectum, i.e. argentaffin cells storing 5-hydroxytryptamine (5HT) and non-argentaffin cells reacting with glucagon, somatostatin and bovine pancreatic peptide (BPP) antibodies. Ultrastructurally, four main types and three rare types of endocrine-like cells have been identified. Among the former cells were: (1) argentaffin EC1 cells, known to store 5HT and substance P, (2) poorly argyrophil L cells, corresponding to the glucagon-immunoreactive cells storing enteroglucagon or glucagon-like immunoreactivity (GLl), (3) inconstantly argyrophil F-like cells, possibly corresponding to BPP-immunoreactive cells, and (4) fairly argyrophil H cells of unknown function. Rare D cells, corresponding to somatostatin cells, N cells, corresponding to neurotensin cells, and P cells, of unknown function, have been also found.
D002838:Chromaffin System / Q000032:analysis*; D003106:Colon / Q000166:cytology*; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D004702:Endocrine Glands / Q000166:cytology*; D004759:Enterochromaffin Cells / Q000032:analysis* / Q000648:ultrastructure; D005934:Glucagon / Q000378:metabolism; D006801:Humans; D010191:Pancreatic Polypeptide / Q000378:metabolism; D012007:Rectum / Q000166:cytology*; D012701:Serotonin / Q000378:metabolism; D013004:Somatostatin / Q000378:metabolism
D012701:Serotonin; D013004:Somatostatin; D010191:Pancreatic Polypeptide; D005934:Glucagon