Effects of dietary butylated hydroxytoluene and phenobarbital on the activities of ornithine decarboxylase and thymidine kinase in rat liver and lung.
Rats were entrained to a 12 h dark/12 h light cycle with food (60% protein +/- 0.5% butylated hydroxytoluene or 0.05% phenobarbital) available only during the first 2 h of the dark period. Under these conditions liver ornithine decarboxylase (ODC) activity in control animals displayed a characteristic diurnal oscillation. In livers of rats fed butylated hydroxytoluene or phenobarbital ODC activity was not increased whereas thymidine kinase (TK) activity was stimulated 4--10 fold at 3 days. In lungs from the same animals ODC and TK activities were unchanged. In rats fed butylated hydroxytoluene for 3 days [3H]thymidine incorporation into DNA was increased in liver but decreased in lung.
D000818:Animals; D002084:Butylated Hydroxytoluene / Q000008:administration & dosage / Q000494:pharmacology*; D002262:Carboxy-Lyases / Q000378:metabolism*; D003408:Cresols / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis; D004032:Diet; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008168:Lung / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009955:Ornithine Decarboxylase / Q000378:metabolism*; D010634:Phenobarbital / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D013936:Thymidine / Q000378:metabolism; D013937:Thymidine Kinase / Q000378:metabolism*
D003408:Cresols; D002084:Butylated Hydroxytoluene; D004247:DNA; D013937:Thymidine Kinase; D002262:Carboxy-Lyases; D009955:Ornithine Decarboxylase; D013936:Thymidine; D010634:Phenobarbital