Comparison of In-111-labeled platelets and iodinated fibrinogen for the detection of deep vein thrombosis.
Indium-111-labeled platelets and I-125 fibrinogen were administered to dogs with experimentally induced deep-vein thrombosis. The thrombus uptake of both labeled compounds was studied as a function of thrombus age. In thrombi less than 24 hr old, thrombus-to-blood ratios for In-111 platelets were about twice as great as those obtained for I-125 fibrinogen. Excellent scintiphotos were obtained with In-111 platelets. In thrombi older than 24 hr, uptake of both agents was low, but good images were still obtained with In-111 platelets. The images in this case are not of thrombi, but rather of damaged vessel wall. Indium-111-labeled platelets are superior to iodinated fibrinogen for imaging fresh thrombi, but offer no advantage for thrombi over 24 hr old.
D000818:Animals; D001792:Blood Platelets; D004285:Dogs; D005340:Fibrinogen; D007204:Indium; D007457:Iodine Radioisotopes; D007553:Isotope Labeling; D011868:Radioisotopes; D011877:Radionuclide Imaging; D013924:Thrombophlebitis / Q000000981:diagnostic imaging*; D013997:Time Factors
D007457:Iodine Radioisotopes; D011868:Radioisotopes; D007204:Indium; D005340:Fibrinogen