[Iron, copper, zinc and cobalt content and activity of respiratory metalloenzymes in animal tissues under toxic hypoxia].
The rabbits being repeatedly poisoned with small doses of sodium cyanide, the activity of succinic dehydrogenase in the tissues does not essentially change. The activity of NAD.H2-cytochrome-c-reductase and NAD.H2-diaphorase in the brain, myocardium and kidneys increases. Under histotoxic hypoxia the level of iron in the tissues increases by 52-93%, that of copper--by 28-36%, of zinc--by 21-74% and of cobalt by 28-40%. There existed a positive correlation between the content of iron and the activity of NAD-dependent enzymes. In nonlethal form of histotoxic hypoxia the content of nonhemin iron and the activity of NAD.H2-cytochrome-c-reductase in the mitochondria of the brain increases by 25% and 17%, respectively, and a direct correlation is revealed between them.
D000818:Animals; D001921:Brain / Q000378:metabolism; D003035:Cobalt / Q000378:metabolism*; D003300:Copper / Q000378:metabolism*; D003486:Cyanides; D003579:Cytochrome Reductases / Q000378:metabolism*; D008058:Dihydrolipoamide Dehydrogenase / Q000378:metabolism*; D000860:Hypoxia / Q000139:chemically induced / Q000378:metabolism*; D007501:Iron / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D011817:Rabbits; D013385:Succinate Dehydrogenase / Q000378:metabolism*; D015032:Zinc / Q000378:metabolism*
D003486:Cyanides; D003035:Cobalt; D003300:Copper; D007501:Iron; D013385:Succinate Dehydrogenase; D003579:Cytochrome Reductases; D008058:Dihydrolipoamide Dehydrogenase; D015032:Zinc
Issledovanie soderzhaniia zheleza. Medi, tsinka, kobal'ta i aktivnosti dykhatel'nykh metallofermentov v tkaniakh zhivotnykh pri toksicheskoi gipoksii.