Hazards of amniocentesis: an unidentifiable fragment.
A 38-year-old woman had amniocentesis performed for advanced maternal age. The karyotype of the cultured amniotic fluid cells showed a minute fragment in all cells analyzed, 47,XY+Fg. The fragment could not be identified. For medical reasons the pregnancy had to be terminated at 34 weeks. Both skin and blood cultures from the aborted fetus showed a 47,XY,21+ karyotype.
D000028:Abortion, Induced; D000328:Adult; D000649:Amniocentesis; D002478:Cells, Cultured; D002871:Chromosome Banding; D005260:Female; D005312:Fetal Blood; D006801:Humans; D007621:Karyotyping; D008423:Maternal Age; D011247:Pregnancy; D012867:Skin / Q000648:ultrastructure