Lack of proliferation of circulating white blood cells in patients with syphilis before and after a Jarisch-Herxheimer reaction.
The occurrence of lymphoblasts in peripheral blood, measured by incorporating tritiated thymidine ([3H]dThd), was studied before, during, and after a Jarisch-Herxheimer reaction in patients with early syphilis. No difference in [3H]dThd incorporation into peripheral white blood cells was found between five patients with syphilis and 19 healthy controls, whereas in 20 cord blood samples [3H]dThd incorporation was significantly increased.
D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D007962:Leukocytes / Q000276:immunology*; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D008938:Mitosis; D010406:Penicillins / Q000627:therapeutic use; D013587:Syphilis / Q000188:drug therapy / Q000276:immunology*
D010406:Penicillins