Effect of delta9-tetrahydrocannabinol on the gastrointestinal tract of the rat.
THC was neither ulcerogenic in 'semi-fasted' of 18-hour fasted rats following an oral dose of 100.0 mg/kg nor did it promote fecal blood loss (51Cr-labelled erythrocyte test) in the fasted rat after a dose of 200.0 mg/kg. On the contrary, 200.0 mg/kg of acetylsalicylic acid was ulcerogenic and caused fecal blood loss in the fasted rat. Neither substance caused mortalities at the doses tested.
D000818:Animals; D001241:Aspirin / Q000633:toxicity; D004064:Digestive System / Q000187:drug effects*; D013759:Dronabinol / Q000008:administration & dosage / Q000633:toxicity*; D004912:Erythrocytes / Q000187:drug effects; D005215:Fasting; D005243:Feces / Q000032:analysis; D005753:Gastric Mucosa / Q000187:drug effects*; D008297:Male; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced
D013759:Dronabinol; D001241:Aspirin