title: [Inductive role of the edges of the bony defect in the process of regeneration of the bones of the cranial vault in adult rabbits].
abstract: In the process of regeneration of the skull vault bones in adult rabbits which proceeds spontaneously after trepanation, the destroyed and changing bone of the defect margins is an inductor of osteogenesis. Coming into the contact with the reacting material in the region of defect and in dura mater, it directs its differention along the path of osteogenesis. In the experiments where the inductor and reacting material were separated by the millipore (0.45 mcm) filter the pores of which did not prevent the penetration of macromolecules and cell processes, the bone regeneration in the region of defect slowed down, as compared with the control. The bone formation de novo was observed in these experiments at first in the places of contact of the millipore filter covering the destroyed bone margins with the reacting material, i. e. in the regions of dura mater adjacent to the filter and in the newly formed connective tissue covering the external surface of the filter. The separation of the defect margins from the reacting material by wax inhibited the bone regeneration. The region of defect was filled by connective tissue scar.
mesh_terms: D000818:Animals; D002682:Chinchilla; D011817:Rabbits; D012886:Skull / Q000473:pathology; D012887:Skull Fractures / Q000473:pathology / Q000503:physiopathology*; D013997:Time Factors; D014945:Wound Healing
vernacular_title: Indutsiruiushchaia rol' kraev kostnogo defekta v protsesse regeneratsii kosteĭ svoda cherepa u vzroslykh krolikov.