[Influence of the dose rate on the therapeutic effect of 60Co-gamma-irradiation in murine adenocarcinoma (author's transl)].
Transplantable adenocarcinomas of C3H-mice were irradiated with doses between 7 and 75 Gy, using a dose rate of 3.6 Gy/min, or with doses from 10 to 80 Gy using dose rates between 0.06 and 0.17 Gy/min from a 60Co-gamma source. A radiation-induced delay of growth or the local cure were recorded. The relative effectiveness of irradiation of the tumor using a low dose rate decreases at first down to a value of 0.66 at 25 to 30 Gy, if the doses are increased; then, if the doses delivered are further increased, it mounts again to 0.88 when the median curative radiation dose is reached.
D000230:Adenocarcinoma / Q000532:radiotherapy*; D000818:Animals; D003037:Cobalt Radioisotopes; D051379:Mice; D008809:Mice, Inbred C3H; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000532:radiotherapy*; D011867:Radioisotope Teletherapy; D011879:Radiotherapy Dosage
D003037:Cobalt Radioisotopes
Der Einfluss der Dosisleistung auf die therapeutische Wirkung von 60Co-Gammabestrahlung beim Adenokarzinom der Maus.