Effect of cortisone upon vascular permeability to antibody.
In rabbits actively sensitized to bovine serum albumin, intracorneal injection of 1 mg. of fluorescein-labeled bovine serum albumin evokes a circular band of fluorescence secondary to precipitation of the diffusing antigen with antibody migrating from the limbal blood vessels. Cortisone treatment prevented or markedly decreased this phenomenon indicating that cortisone exerts a definite inhibitory effect upon vascular permeability to antibody molecules.
D000818:Animals; D000906:Antibodies; D002199:Capillary Permeability / Q000187:drug effects*; D003315:Cornea; D003348:Cortisone / Q000494:pharmacology*; D011817:Rabbits
D000906:Antibodies; D003348:Cortisone