Aroyl- and arylisoquinolineacetic acids as antiinflammatory agents.
A series of 1-benzoyl- and 1-phenylisoquinolineacetic acid derivatives was prepared and tested for antiinflammatory activity. The most potent compound synthesized, 1-(4-chlorophenyl)-3-isoquinolineacetamide, was as active as phenylbutazone in the Evans blue carrageenan-induced pleural effusion assay but inactive in the adjuvant-induced arthritis model of chronic inflammation.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D001169:Arthritis, Experimental / Q000188:drug therapy; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000627:therapeutic use; D010653:Phenylbutazone / Q000627:therapeutic use; D010996:Pleural Effusion / Q000188:drug therapy; D051381:Rats
D000893:Anti-Inflammatory Agents; D007546:Isoquinolines; D010653:Phenylbutazone