Trimethoprim-sulphamethoxazole and thrombocytopenia.
Thrombocytopenia is an uncommon but serious side effect of the antimicrobial combination of trimethoprim and sulphamethoxazole. Thirty-one cases in seven years, including two deaths, have been reported to the Australian Adverse Drug Reactions Registry. Females were affected twice as frequently as males. In 70% of the patients platelet counts were 20x10(9)/L or less. Thrombocytopenia which is associated with this agent may occur at any age.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000818:Animals; D002675:Child, Preschool; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D013420:Sulfamethoxazole / Q000009:adverse effects*; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000453:epidemiology; D014295:Trimethoprim / Q000009:adverse effects*
D004338:Drug Combinations; D014295:Trimethoprim; D013420:Sulfamethoxazole