title: Propranolol in thyrotoxicosis. Cardiovascular changes during thyroidectomy in patients pre-treated with propranolol.
abstract: The cardiovascular changes during anaesthesia and thyroidectomy have been studied in seven thyrotoxic patients prepared with propranolol. The heart rate and cardiac rhythm remained very stable throughout surgery. A 20% increase in mean arterial pressure occurred during surgical stimulation. A decrease in cardiac output, due to decreased stroke volume, occurred during surgical stimulation. A decrease in cardiac output, due to decreased stroke volume, occurred during surgery, reaching a maximum of 21% during ligation of the thyroid vessels and returning to pre-operative values by the end of surgery. The fall in cardiac output was accompanied by raised central venous pressure and raised total peripheral resistance.
mesh_terms: D000328:Adult; D000768:Anesthesia, General; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy / Q000601:surgery*; D011300:Preoperative Care; D011433:Propranolol / Q000494:pharmacology* / Q000627:therapeutic use; D013965:Thyroidectomy
chemical_list: D011433:Propranolol