[Development of a method of screening for hemoglobin S for the purpose of genetic consultation in Cuba. Results of an analysis of 24,000 blood samples].
Electrophoretic screening system is worked out, which combines a high resolving power in polyacrylamide gel and a principle of simultaneous treatment of a large number of examples. 24,000 blood examples from inhabitants of Havana province (Cuba) are analysed in order to check the efficiency of the method described, to find the hemoglobin S frequency and to use these results in further genetic consulting. The frequency of hemoglobin S carriers is found to be 3.0%, that of hemoglobin C--0.7%. 15 rare hemoglobin variants are detected, 9 variants of alpha-chain and 3 variants of beta-chain are detected. One case was a result of hemoglobin S and a variant of alpha-chain interaction. Frequencies of S, C and A alleles were 0.016, 0.0038 and 0.98 respectively.
D000755:Anemia, Sickle Cell / Q000097:blood*; D002648:Child; D003462:Cuba; D004586:Electrophoresis; D005787:Gene Frequency; D006451:Hemoglobin, Sickle / Q000032:analysis*; D006801:Humans; D007231:Infant, Newborn; D008403:Mass Screening; D008722:Methods; D012805:Sickle Cell Trait / Q000097:blood* / Q000453:epidemiology / Q000235:genetics
D006451:Hemoglobin, Sickle
Razrabotka metodiki skrinirovaniia dlia obnaruzheniia gemoglobina S s tsel'iu geneticheskogo konsul'tirovaniia na Kube. Rezul'taty analiza 24,000 obraztsov krovi.