Intra-uterine extra-amniotic prostaglandin F2-alpha in the management of patients with intra-uterine fetal death.
The problems of a conservative approach to the management of patients with intra-uterine fetal death are presented, and the technique of intra-uterine, extra-amniotic infusion of prostaglandin F2-alpha (PGF2alpha) is described. This involves the repeated infusion of a solution of PGF2alpha into the extra-amniotic space to induce labour in patients in whom pregnancy is complicated by intra-uterine fetal death. Pregnancy was successfully terminated by this method in 9 patients with intra-uterine fetal death. The mean induction-delivery interval was 10,2 hours. There were no side-effects, and the results were similar to those reported by other authors who used a similar technique of inducing labour. Past and present methods of inducing labour in patients with intra-uterine fetal death are reviewed and discussed.
D000650:Amnion; D005260:Female; D005313:Fetal Death / Q000188:drug therapy*; D006801:Humans; D007263:Infusions, Parenteral / Q000379:methods; D007751:Labor, Induced; D011247:Pregnancy; D011460:Prostaglandins F / Q000008:administration & dosage / Q000627:therapeutic use*
D011460:Prostaglandins F