Hereditary angioneurotic edema and Charcot-Marie-Tooth disease in the same family.
In one family two genetic diseases were transmitted as autosomal dominant traits; hereditary angioneurotic edema was inherited from the paternal side and Charcot-Marie Tooth disease from the maternal side of the family. The conditions occurred separately in 8 and 11 members respectively and together (an exceedingly rare occurrence) in 3. Of six siblings, two girls and four boys, all had Charcot-Marie-Tooth disease, and three, the two girls and one of the boys, also had hereditary angioneurotic edema.
D000293:Adolescent; D000328:Adult; D000799:Angioedema / Q000097:blood / Q000150:complications / Q000235:genetics*; D002607:Charcot-Marie-Tooth Disease / Q000097:blood / Q000150:complications / Q000235:genetics*; D002648:Child; D003174:Complement C1 Inactivator Proteins / Q000097:blood; D003181:Complement C4 / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009133:Muscular Atrophy / Q000235:genetics*; D010375:Pedigree
D003174:Complement C1 Inactivator Proteins; D003181:Complement C4