The anticholinergic effects of dicyclomine hydrochloride in uninhibited neurogenic bladder dysfunction.
A preliminary study to assess objectively the effects of dicyclomine upon uncontrolled detrusor contractions and bladder capacity was undertaken in 14 patients with a cystometric diagnosis of uninhibited neurogenic bladder. Response was measured by cystometry performed 1, 2 and 4 hours after a 20 mg. oral dose. Of the 14 patients 11 had significant blockade of uninhibited contractions and a concomitant increase in bladder capacity. Similar but less dramatic changes were noted in the remaining 3 patients. Dicyclomine seems to have effective anticholinergic properties. No remarkable side effects were observed.
D000328:Adult; D000368:Aged; D003509:Cyclohexanecarboxylic Acids / Q000627:therapeutic use*; D004025:Dicyclomine / Q000627:therapeutic use*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010276:Parasympatholytics / Q000627:therapeutic use*; D013997:Time Factors; D001750:Urinary Bladder, Neurogenic / Q000188:drug therapy*
D003509:Cyclohexanecarboxylic Acids; D010276:Parasympatholytics; D004025:Dicyclomine