Effects of piretanide, bumetanide and frusemide on electrolyte and urate excretion in normal subjects.
1. The pharmacological actions of a new short acting loop diuretic were investigated in nine healthy male subjects and compared with those of frusemide and bumetanide. Subjects received 6 mg piretanide/day, 40 mg frusemide/day or 1 mg bumetanide/day for a period of 1 week. 2. Comparison of effects following the first dose administered showed that 6 mg piretanide is of similar potency to 40 mg frusemide in terms of diuresis, natriuresis and kaliuresis but is less potent than 1 mg bumetanide. 3. All three diuretics caused a decrease in urate excretion and a rise in serum uric acid. 4. Piretanide was well tolerated. Further investigation is required to ascertain what clinical advantage it offers over frusemide and bumetanide.
D000328:Adult; D002034:Bumetanide / Q000494:pharmacology*; D004232:Diuretics / Q000494:pharmacology*; D004573:Electrolytes / Q000652:urine*; D005665:Furosemide / Q000494:pharmacology*; D006801:Humans; D008297:Male; D011188:Potassium / Q000652:urine; D012964:Sodium / Q000652:urine; D013997:Time Factors; D014527:Uric Acid / Q000652:urine*
D004232:Diuretics; D004573:Electrolytes; D002034:Bumetanide; D014527:Uric Acid; D005665:Furosemide; D012964:Sodium; D011188:Potassium