A comparative study of the effects of cinnarizine, sulpiride and thiethylperazine on vestibular nystagmus in rabbits.
The effects of cinnarizine, sulpiride, thiethylperazine and a placebo on vestibular nystagmus in rabbits were investigated. The nystagmus was provoked by means of a torsion swing. A suppressive effect was shown by all drugs and not by the placebo. A fast and strong effect was seen after the administration of sulpiride, however this effect decreased after 1 h. The onset of the effect of cinnarizine was slower but the effect lasted longer. Thiethylperazine had a clear suppressive effect but less strong and shorter than that of the other two drugs.
D000818:Animals; D002936:Cinnarizine / Q000494:pharmacology*; D004558:Electric Stimulation; D004584:Electronystagmography; D005133:Eye Movements / Q000187:drug effects*; D010879:Piperazines / Q000494:pharmacology*; D010919:Placebos; D011817:Rabbits; D013469:Sulpiride / Q000494:pharmacology*; D013847:Thiethylperazine / Q000494:pharmacology*; D013997:Time Factors
D010879:Piperazines; D010919:Placebos; D002936:Cinnarizine; D013469:Sulpiride; D013847:Thiethylperazine