Effect of high-dose melphalan on marrow and intestinal epithelium in mice pretreated with cyclophosphamide.
The lethal effect of high-dose melphalan in mice could be offset by pretreatment with cyclophosphamide, cytosine arabinoside or low-dose melphalan. The reason for improved survival is unclear. Althoug animals given high-dose melphalan died with symptoms of gut death, in only one instance, that with low-dose melphalan itself, did pretreatment protect the intestinal epithelium as measured by the microcolony assay. A small enhancement in the recovery of the haemopoietic tissue in pretreated animals was noted, although this on its own is unlikely to explain the phenomenon. Experiments in tumour-bearing mice showed that pretreatment with cyclophosphamide did not reduce the toxicity of melphalan to the Lewis lung carcinoma.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells; D002470:Cell Survival / Q000187:drug effects; D002999:Clone Cells; D003520:Cyclophosphamide / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects; D007422:Intestines / Q000166:cytology / Q000187:drug effects*; D008297:Male; D008558:Melphalan / Q000633:toxicity*; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy
D003520:Cyclophosphamide; D008558:Melphalan