The significance of some modifying factors during transplacental blastomogenesis by ethylnitrosourea in rabbits.
The development of the transplacental blastomogenesis induced by ethylnitrosourea (ENU) was studied in rabbits under the influence of modifying factors (organospecific immunity, chronic irradiation of the peripheral nerve, injection of methylnitrosourea -- MNU). Statistical analysis of the results showed that the postnatal immunization by the antigen prepared from homologous tissue of the peripheral nerve or its chronic irritation always stimulates the frequency of the tumors development. The injection of MNU inhibits the tumorigenesis in the tested animals. According to the data different modifying factors distinctly act upon the transplacental blastomogenesis in rabbits.
D000818:Animals; D000941:Antigens / Q000008:administration & dosage; D005038:Ethylnitrosourea; D005260:Female; D007680:Kidney Neoplasms / Q000209:etiology* / Q000473:pathology; D008297:Male; D008431:Maternal-Fetal Exchange; D008770:Methylnitrosourea / Q000494:pharmacology; D009374:Neoplasms, Experimental / Q000209:etiology / Q000517:prevention & control; D009417:Nerve Tissue / Q000276:immunology; D009607:Nitrosourea Compounds; D010524:Peripheral Nervous System Neoplasms / Q000209:etiology* / Q000473:pathology; D010812:Physical Stimulation; D011247:Pregnancy; D011817:Rabbits; D012584:Sciatic Nerve / Q000502:physiology
D000941:Antigens; D009607:Nitrosourea Compounds; D008770:Methylnitrosourea; D005038:Ethylnitrosourea