title: [Skincycle of a new spontaneous mutant (Nackig) with abnormal hair keratinization in the mouse (author's transl)].
abstract: The pathomorphological and pathophysiological reactions of the first skincycle of the mutant (Ng) were histologically investigated. 1. During the hair growth disturbances as the result of imperfect keratinisation changes of the morphology and function of different skin areas could be observed. 2. The developments of abnormal thinner hair growth were correlated to hyperorthokeratotic, inter-respectively intrafollicular hyperplasia of the epidermis and to infraseboglandular hypoplasia of the follicles. 3. The hyper- and hypoplasia of the epidermis corresponded with a functional pseudohypo- and pseudohypertrophy of the cutis. 4. During the skincycle the perifollicular epithelium ranged from the inter- to intrafollicular skin areas. The inter- and intrafollicular epidermal sections varied simultaneously. 5. These results are important for the understanding of some pathomorphological and pathophysiological reactions of skin compartments of man.
mesh_terms: D000818:Animals; D006197:Hair; D007633:Keratins / Q000096:biosynthesis*; D051379:Mice; D008815:Mice, Inbred Strains; D009154:Mutation; D012867:Skin / Q000473:pathology*
chemical_list: D007633:Keratins
vernacular_title: Uber den Hautcyclus einer neuen Spontanmutante (Nackig) mit mangelhafter Haarkeratinisierung bei der AMus.