title: [Metabolic changes in renal insufficiency].
abstract: In the chronic renal insufficiency is shown a decrease as well as an accumulation of some metabolites in the organism. There appear dietarily conditioned insufficiency states and also decreased rates of synthesis of 1,25-OH cholecalciferol , of the renal erythropoietic factor and of histidin. Apart from nitrogenous metabolic end products also the molecules with a middle molecular weight (300-1.500 Dalton) are accumulated. From this, among others, the trade-off hypothesis may be derived, which characterizes the biochemical distrubances in renal insufficiency as a sequel of the accumulation of metabolic regulators. In the analysis of the middle molecule fraction by means of combined chromatographic techniques we succeeded in isolating an inhibitor of glucose utilisation and in defining of some of its biochemical qualities. With the help of this survey the authors demonstrate a new way of thinking and a promising direction for the solution of still unclear probelms of renal insufficiency.
mesh_terms: D000596:Amino Acids / Q000378:metabolism; D000601:Amino Acids, Essential / Q000172:deficiency; D004044:Dietary Proteins; D004921:Erythropoietin / Q000096:biosynthesis; D005943:Gluconeogenesis; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism*; D014118:Toxins, Biological / Q000378:metabolism; D014511:Uremia / Q000378:metabolism
chemical_list: D000596:Amino Acids; D000601:Amino Acids, Essential; D004044:Dietary Proteins; D014118:Toxins, Biological; D004921:Erythropoietin
vernacular_title: Stoffwechselveränderungen bie Niereninsuffizienz.