A two-step fibrinogen--fibrin transition in blood coagulation.
The kinetics of the thrombin-catalysed release of fibrino-peptides A and B from human fibrinogen have been investigated and a mechanism correlating the release of fibrinopeptides to fibrin formation is presented. The sequential release of fibrinopeptides results in sequential activation of two sets of polymerisation sites.
D001665:Binding Sites; D001777:Blood Coagulation / Q000187:drug effects; D001778:Blood Coagulation Disorders / Q000378:metabolism; D002118:Calcium / Q000494:pharmacology; D005337:Fibrin / Q000378:metabolism*; D005340:Fibrinogen / Q000378:metabolism*; D005344:Fibrinopeptide A / Q000378:metabolism; D005345:Fibrinopeptide B / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D046911:Macromolecular Substances; D011485:Protein Binding; D013917:Thrombin / Q000378:metabolism
D046911:Macromolecular Substances; D005344:Fibrinopeptide A; D005345:Fibrinopeptide B; D005337:Fibrin; D005340:Fibrinogen; D013917:Thrombin; D002118:Calcium