Rat hippocampal norepinephrine response to cholinesterase inhibition.
In this study, 13 groups of rats were injected with the insecticide Disulfoton (0-0-diethyl S-2-[(ethylthio) ethyl] phosphorodithioate), sacrificed after various time intervals and levels of hippocampal norepinephrine determined. Results indicate that this cholinesterase inhibiting compound caused a significant decrease (congruent to 14%) in hippocampal norepinephrine within 3 hours of exposure. This reduction was maintained for at least 48 hours. Titers of norepinephrine had returned to control levels when measured 5 days after a single drug administration. Chronic poisoning also caused depressed norepinephrine levels, although not significantly below those observed in acutely treated animals.
D000818:Animals; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D003864:Depression, Chemical; D004222:Disulfoton / Q000494:pharmacology*; D005260:Female; D006624:Hippocampus / Q000378:metabolism*; D066298:In Vitro Techniques; D007306:Insecticides / Q000494:pharmacology*; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D013997:Time Factors
D002800:Cholinesterase Inhibitors; D007306:Insecticides; D004222:Disulfoton; D009638:Norepinephrine