Liver function and lactate metabolism in the ill surgical patient.
Liver function and lactate metabolism were investigated in non-shocked, severely ill surgical patients. Fasting venous blood lactate concentration was increased and plasma liver function tests were abnormal in ill patients compared with controls. Ill patients were glucose-intolerant and blood lactate changes following intravenous glucose infusion were similar in both ill and control patients. Blood lactate half-life was increased in ill patients following a sodium L-lactate infusion, suggesting that the increased fasting lactate concentration may have been due to decreased hepatic removal rather than to increased peripheral production of lactate.
D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D005260:Female; D006207:Half-Life; D006801:Humans; D007773:Lactates / Q000097:blood*; D008099:Liver / Q000503:physiopathology*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D013514:Surgical Procedures, Operative
D001786:Blood Glucose; D007773:Lactates