Studies of cell-mediated immunity in human glomerulonephritis by macrophage migration inhibition test.
Using the macrophage migration inhibition test (MIT), a total of 113 patients with various renal diseases, namely glomerulonephritis (GN), were studied for evidence of cell-mediated immunity to various soluble antigens prepared. The positive rate of MIT in the presence of streptococcal antigen, glomerular basement membrane antigen, renal tubular epithelial antigen and heat-aggregated IgG antigen was 15, 23, 16 and 15%, respectively. Out of 15 positive patients who were able to be evaluated with those four antigens, 9 cases exhibited cellular hypersensitivity to two or more antigens at the same time. These findings suggest that there is an abnormal cellular response to certain antigen or widespread cell-mediated hypersensitivity to a variety of antigens in certain forms of human GN.
D000941:Antigens; D000942:Antigens, Bacterial; D000989:Antistreptolysin / Q000276:immunology; D001485:Basement Membrane / Q000276:immunology; D002464:Cell Migration Inhibition; D004848:Epithelium / Q000276:immunology; D005500:Follow-Up Studies; D005921:Glomerulonephritis / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D007074:Immunoglobulin G; D007678:Kidney Glomerulus / Q000276:immunology; D007684:Kidney Tubules / Q000276:immunology; D008264:Macrophages / Q000276:immunology*; D011239:Prednisolone / Q000627:therapeutic use; D013291:Streptococcus / Q000276:immunology
D000941:Antigens; D000942:Antigens, Bacterial; D007074:Immunoglobulin G; D000989:Antistreptolysin; D011239:Prednisolone