title: The effect of the administration of spironolactone on the concentration of plasma testosterone, estradiol and cortisol in male dogs (1).
abstract: The effect of the administration of spironolactone, deacetylspironolactone, aldadiene or soldactone on the concentration of plasma testosterone, estradiol, and cortisol was examined in male dogs. Decreases of 60 to 75% in plasma testosterone and estrodiol occur only at high doses (100 mg/kg) of spironolactone or deacetylspironolactone but not at low doses of spironolactone (5 to 10 mg/kg); they occur concomitantly with similar decreases of androgen formation by the testis. No decreases were detected with aldadiene or soldactone. Treatment of dogs with spironolactone (100 mg/kg) also lowered by 50 to 65% the concentration of cortisol in adrenal venous plasma.
mesh_terms: D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004285:Dogs; D004958:Estradiol / Q000097:blood*; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D013094:Spermatozoa / Q000378:metabolism; D013148:Spironolactone / Q000494:pharmacology*; D013737:Testis / Q000201:enzymology; D013739:Testosterone / Q000097:blood*; D013997:Time Factors
chemical_list: D013148:Spironolactone; D013739:Testosterone; D004958:Estradiol; D003577:Cytochrome P-450 Enzyme System; D006854:Hydrocortisone