A fine structural study of liver (littoral) cells of methylmercury fed Japanese quail (Coturnix coturnix japonica).
Tissues of Japanese quails were subjected to electron microscopical study. The birds had received 0-8 ppm methylmercury added to their diets for 6 weeks. The ultrastructural changes in the littoral cells of the liver were swollen mitochondria, with dilatation of the endoplasmic reticulum, loss of ribosomes from the rough endoplasmic reticulum and an increase in the number of vesicles in the cytoplasm. The nuclear membrane in some littoral cells became dilated, and the nuclear chromatin was condensed. The physiological effect of the destruction of the littoral cells is discussed.
D000818:Animals; D002467:Cell Nucleus / Q000187:drug effects / Q000648:ultrastructure; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology*; D002843:Chromatin / Q000187:drug effects / Q000648:ultrastructure; D003370:Coturnix; D003593:Cytoplasm / Q000187:drug effects / Q000648:ultrastructure; D004721:Endoplasmic Reticulum / Q000187:drug effects / Q000648:ultrastructure; D005260:Female; D008099:Liver / Q000187:drug effects* / Q000648:ultrastructure; D008297:Male; D008630:Mercury Poisoning / Q000473:pathology*; D008930:Mitochondria, Liver / Q000187:drug effects; D008933:Mitochondrial Swelling / Q000187:drug effects; D009685:Nuclear Envelope / Q000187:drug effects / Q000648:ultrastructure; D012270:Ribosomes / Q000187:drug effects / Q000648:ultrastructure
D002843:Chromatin