Organ culture of the 16th gestation day mouse labyrinth. A model suggestion for pre- and post-partum development.
The 16th day mouse embryo inner ear was explanted and cultured "in vitro" for 6 days, which corresponds to 1 day post-partum development "in vivo". A normal development occurred both when the inner ear anlage was divided into a vestibular and a cochlear portion and when it was cultured as a whole. The present model system may provide a helpful tool in the study of both normal development and inner ear pathology.
D000818:Animals; D007758:Ear, Inner / Q000166:cytology / Q000196:embryology / Q000254:growth & development*; D005260:Female; D051379:Mice; D008808:Mice, Inbred CBA; D008954:Models, Biological; D009924:Organ Culture Techniques; D011247:Pregnancy