[Mechanism of the effect of diazepam on acetylcholine concentration in mouse brain].
Intraperitoneal injection of diazepam (20 mg/kg) caused an increase of free and bound acetylcholine in the mouse brain. Diazepam pretreatment (20 mg/kg) increased galanthamine anticholinesterase activity and its toxicity; as to physostigmine, armine, and paraoxon toxicity--it remained unchanged. It is supposed that diazepam blocks the release of aetylcholine from the cholinergic nerve terminals which should result in a decrease of functional acetylcholine concentrations in the synapse.
D000109:Acetylcholine / Q000032:analysis*; D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000201:enzymology; D001923:Brain Chemistry / Q000187:drug effects*; D002800:Cholinesterase Inhibitors / Q000633:toxicity; D003975:Diazepam / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005702:Galantamine / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009578:Nitrobenzenes / Q000633:toxicity; D009943:Organophosphorus Compounds / Q000633:toxicity; D010261:Paraoxon / Q000633:toxicity; D010830:Physostigmine / Q000633:toxicity
D002800:Cholinesterase Inhibitors; D009578:Nitrobenzenes; D009943:Organophosphorus Compounds; D005702:Galantamine; D010830:Physostigmine; D000110:Acetylcholinesterase; D000109:Acetylcholine; D003975:Diazepam; D010261:Paraoxon
Issledovanie mekhanizma vliianiia diazepama na soderzhanie atsetilkholina v golovnom mozge mysheĭ.