Modification of the toxicity of acetylcholine by prior atropinization in mice.
The potentiation of acetylcholine (Ach) toxicity in mice with prior atropinization was tested. The experiments were carried out with three doses of 200 mg, 300 mg, and 400 mg/kg of Ach administered ip. Prior atropinization was observed to potentiate the Ach toxicity at all dose levels of atropine except the highest in the group that received Ach 200 mg/kg and the results were variable in the other two groups.
D000109:Acetylcholine / Q000037:antagonists & inhibitors / Q000633:toxicity*; D000818:Animals; D001285:Atropine / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D005260:Female; D008297:Male; D051379:Mice
D001285:Atropine; D000109:Acetylcholine