Cerebrospinal fluid penetration of amikacin.
Adult volunteers underwent a single lumbar puncture 1 to 8.5 h after one 7.5-mg/kg intramuscular amikacin injection. Eighteen showed no detectable drug in cerebrospinal fluid; six had concentrations <0.5 mug/ml.
D000328:Adult; D000583:Amikacin / Q000097:blood / Q000134:cerebrospinal fluid*; D006801:Humans; D007612:Kanamycin / Q000031:analogs & derivatives*; D013997:Time Factors
D007612:Kanamycin; D000583:Amikacin