Progesterone, 20alpha-dihydroprogesterone and PGF; interrelated hormonal changes during pseudo-pregnancy in the rat.
Ovarian and uterine tissue concentrations of progesterone, 20alpha-dihydroprogesterone (20alphaOHP) and prostaglandin F (PGF) were measured during hormonally-induced pseudopregnancy, as were plasma levels of progesterone and 20alphaOHP, in hysterectomised and sham-operated rats. Elevated levels of PGF in uterine and ovarian tissues were coincident with declining concentrations of progesterone and increasing concentrations of 20alphaOHP in the sham-operated rats. Maximum PGF concentrations were apparent in uterine tissue 14 days after hCG injection, coincident with the plasma, ovarian and uterine nadir concentrations of progesterone. A small but statistically significant increase in ovarian PGF was apparent at this time in sham-operated rats. This elevation of ovarian PGF was abolished by hysterectomy.
D004092:20-alpha-Dihydroprogesterone / Q000097:blood / Q000378:metabolism*; D000818:Animals; D006063:Chorionic Gonadotropin; D005260:Female; D007044:Hysterectomy; D010053:Ovary / Q000378:metabolism; D011374:Progesterone / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism*; D011460:Prostaglandins F / Q000378:metabolism*; D011555:Pseudopregnancy / Q000139:chemically induced / Q000378:metabolism*; D051381:Rats; D013997:Time Factors; D014599:Uterus / Q000378:metabolism
D006063:Chorionic Gonadotropin; D011460:Prostaglandins F; D004092:20-alpha-Dihydroprogesterone; D011374:Progesterone