Measurement of chloroprocaine and procaine in plasma by flame ionization gas-liquid chromatography.
We describe an isothermal gas-liquid chromatographic procedure developed for measuring procaine and chloroprocaine in plasma. The unchanged drug is extracted into toluene from alkalinized plasma, together with an internal standard. The solvent is removed, the residue redissolved in methanol, and aliquots are injected into a 91.5-cm gas-liquid chromatographic column containing 3% OV-210. Sensitivity of detection is in the nanogram range.
D005410:Flame Ionization / Q000379:methods; D006801:Humans; D011343:Procaine / Q000031:analogs & derivatives* / Q000097:blood*
D011343:Procaine; C004616:chloroprocaine