Effects of adrenaline and isoprenaline on hepatic venous haemodynamics and venous return in the dog.
1. The effects of adrenoceptor agonists on venous haemodynamics were examined, utilizing the lower half perfusion method in dogs. 2. Femoral arterial pressure, central venous pressure, thoracic vena caval flow, abdominal vena caval flow, renal venous flow and femoral venous flow were measured simultaneously usning electronic transducers and electromagnetic flow-meters. Hepatic volume change was monitored by the strain-guage arch. 3. Single injections of both adrenaline (1.0 microgram/kg) and isoprenaline (1.0 microgram/kg) intra-aortically produced an increase in venous return, adrenaline transiently and isoprenaline continuously. 4. Epinephrine increased hepatic venous flow, while isoprenaline increased only abdominal vena caval flow. 5. These findings suggest that effects of alpha-adrenoceptors are more pronounced on the hepatic vein, while on other peripheral veins, effects of beta-adrenoceptors are more pronounced.
D000818:Animals; D004285:Dogs; D004837:Epinephrine / Q000494:pharmacology*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006503:Hepatic Veins / Q000187:drug effects; D007545:Isoproterenol / Q000494:pharmacology*; D008297:Male; D013997:Time Factors; D014680:Veins / Q000187:drug effects
D007545:Isoproterenol; D004837:Epinephrine