Treatment of acute intermittent porphyria with large doses of propranolol.
A patient had an acute attack of intermittent porphyria with severe neurologic manifestations, hypertension, and tachycardia. Treatment with propranolol hydrochloride (Deralin [Israel]; Inderal, comparable US product) intravenously administered in a total dose of 284 mg during a period of 18 hours, was followed by clinical remission associated with a decline in urinary excretion of porphyrin precursors.
D000284:Administration, Oral; D000328:Adult; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications; D007275:Injections, Intravenous; D009461:Neurologic Manifestations; D011164:Porphyrias / Q000150:complications / Q000188:drug therapy*; D011433:Propranolol / Q000008:administration & dosage* / Q000627:therapeutic use; D012075:Remission, Spontaneous; D013610:Tachycardia / Q000150:complications
D011433:Propranolol