[Cardiac arrhythmias of hypothalamic origin].
It was established in chronic rabbit experiments that periodical prolonged electric stimulation of the hypothalamic ventrolateral nucleus may induce, besides tachycardia and ventricular extrasystole, episodes of cardiac fibrillation and sudden death from ventricular fibrillation. The development of cardiac fibrillation is associated with increased content of catecholamines in the blood and myocardium. It was also found that the energy-producing activity of the mitochondria and active ion transportation were impaired in the myocardium, the intracellular content of potassium and sodium was changed, and the ultrastructure of the heart muscle was markedly altered. It was shown that the predominance of parasympathetic effects over sympathetic was one of the factors determining the resistance of the heart to the development of cardiac fibrillation of hypothalamic origin.
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000209:etiology*; D002395:Catecholamines / Q000378:metabolism; D004558:Electric Stimulation; D007031:Hypothalamus / Q000503:physiopathology*; D008929:Mitochondria, Heart / Q000378:metabolism; D009200:Myocardial Contraction; D009206:Myocardium / Q000473:pathology; D010085:Oxidative Phosphorylation; D010286:Paraventricular Hypothalamic Nucleus / Q000503:physiopathology*; D011817:Rabbits
D002395:Catecholamines
Serdechnye aritmii gipotalamicheskogo proiskhozhdeniia.