Uptake of dopamine and 5-hydroxytryptamine by platelets of patients with Parkinsonism.
The uptake of tritiated dopamine and 5-hydroxytryptamine by platelets from 11 patients with Parkinsonism who were not receiving any medication, and from 11 control subjects matched for sex and for age within a decade was compared. No significant differences were found in the uptake of either amine. Our findings, therefore, provide no support for the belief that there is a generalised defect of dopamine systems in Parkinson's disease.
D000328:Adult; D000368:Aged; D001772:Blood Cell Count; D001792:Blood Platelets / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism*
D012701:Serotonin; D004298:Dopamine