A short term peroral study of the food colour, Ponceau 6R in pigs.
Ponceau 6R (the tetrasodium salt of 1-(4-sulpho-1-naphthyl-azo)-2-naphthol-3,6,8-trisulphonic acid) was fed to pigs at dietary levels of 0 (control), 100, 500 and 1500 mg/kg body wt./day for 102--105 days. In the 1500-mg group a decrease in weight gain and food utilization was seen, and 1 pig died with a hemolytic anaemia. Dose dependent discolouration was seen of the connective tissue in the groups given 1500 and 500 mg/kg body wt. For this effect the no-effect-level was 100 mg Ponceau 6R/kg body wt. per day.
D000743:Anemia, Hemolytic / Q000139:chemically induced; D000818:Animals; D001391:Azo Compounds / Q000633:toxicity*; D003238:Connective Tissue / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D005505:Food Coloring Agents / Q000633:toxicity*; D008297:Male; D009282:Naphthalenesulfonates / Q000633:toxicity*; D012867:Skin / Q000187:drug effects; D013552:Swine
D001391:Azo Compounds; D005505:Food Coloring Agents; D009282:Naphthalenesulfonates; C017664:ponceau 6R