[Osteopetrosis in mice caused by ectomesenchymal lesions].
Pathogenesis of osteopetrosis in mice homozygotic for microphthalmia (symbol mi) mutant gene has been studied. Heparin concentration in the blood of mi/mi mice was demonstrated to be 10 times as little as the normal. Administration of different doses of heparin (1, 5, 10 per g of body weight) at different intervals (2--20, 10--20 and 20--25 days including) of their postnatal development causes partial or complete normalization in the construction of the central part of diaphysis of tubular bones. The number of heparin-secreting mast cells, derivatives of the neural crest is less than normal. Osteopetrosis in mi/mi mice is an integral part of the complex syndrom produced by the damage of neural crest cells.
D000818:Animals; D002452:Cell Count; D005269:Femur / Q000196:embryology / Q000473:pathology*; D006493:Heparin / Q000008:administration & dosage / Q000096:biosynthesis / Q000172:deficiency; D008407:Mast Cells / Q000378:metabolism; D008648:Mesoderm / Q000473:pathology*; D051379:Mice; D008817:Mice, Mutant Strains; D010010:Osteoclasts / Q000187:drug effects / Q000378:metabolism; D010022:Osteopetrosis / Q000209:etiology*; D010281:Parathyroid Hormone / Q000172:deficiency
D010281:Parathyroid Hormone; D006493:Heparin
Osteopetroz u myshi, obuslovlennyĭ porazheniem ektomezenkhimy.