Influence of agents which modulate thromboxane A2 synthesis or action on R3230AC mammary carcinoma.
The effects of agents which modulate thromboxane A2 synthesis or action, were tested in the R3230AC transplanted mammary tumour. Three different inhibitors of thromboxane A2 synthesis or action (copper, dipyridamole and diazepam) all caused an increase in tumour growth. Colchicine and melatonin, both stimulators of thromboxane A2 synthesis, inhibited the growth of the tumour significantly.
D000818:Animals; D003078:Colchicine / Q000494:pharmacology; D003300:Copper / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D004176:Dipyridamole / Q000494:pharmacology; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy* / Q000378:metabolism; D008550:Melatonin / Q000494:pharmacology; D051381:Rats; D013928:Thromboxane A2 / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000502:physiology*; D013931:Thromboxanes / Q000502:physiology*
D013931:Thromboxanes; D013928:Thromboxane A2; D004176:Dipyridamole; D003300:Copper; D008550:Melatonin; D003975:Diazepam; D003078:Colchicine