The fate of saccharin impurities: the excretion and metabolism of toluene-2-sulphonamide in man and rat.
Oral doses (20 mg/kg) of [Me-14C]toluene-2-sulphonamide were rapidly eliminated by rats (92% of dose in 24 h). Most of the 14C (88%) was recovered in the urine within 7 days with litte (5%) in the faeces. Larger oral doses (125 and 200 mg/kg) were eliminated more slowly (70 and 43% respectively in 24 h) but the overall distribution of 14C between urine and faeces was unchanged. 2. Low oral doses (0.2--0.4 mg/kg) of [Me-14C]toluene-2-sulphonamide were excreted more slowly in man than in the rat, with about 50% recovered in the urine in 24 h and 80% in 48 h. Negligible 14C (less than 1%) appeared in the faeces. 3. The main metabolites of toluene-2-sulphonamide were 2-sulphamoylbenzyl alcohol and its sulphate and glucuronic acid conjugates (80% of the 14C in the urine of rats and 35% in man) and saccharin (35% in man and 3% in the rat). Other metabolities found in the urine were 2-sulphamoylbenzoic acid (2% in the rat and 4% in man) and N-acetyltoluene-2-sulphonamide (6% in rat and 2% in man) together with unchanged compound (5% in rat and 3% in man).
D000818:Animals; D001711:Biotransformation; D002845:Chromatography; D005243:Feces / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D051381:Rats; D012439:Saccharin; D013053:Spectrophotometry; D013449:Sulfonamides / Q000378:metabolism* / Q000652:urine; D014050:Toluene / Q000031:analogs & derivatives* / Q000378:metabolism / Q000652:urine
D013449:Sulfonamides; D014050:Toluene; D012439:Saccharin