Piperazinylpyrazines with central serotoninmimetic activity.
A series of 2-(1-piperazinyl)pyrazines was synthesized and evaluated for central serotonin-like activity. The most interesting member of the series, 6-chloro-2(1-piperazinyl)pyrazine (3a), had pharmacological properties characteristic of potent central serotoninmimetic activity and only weak peripheral serotoninmimetic action. Structural similarities between 3a and serotonin are discussed.
D000818:Animals; D002490:Central Nervous System / Q000187:drug effects; D005260:Female; D066298:In Vitro Techniques; D051379:Mice; D008968:Molecular Conformation; D009119:Muscle Contraction / Q000187:drug effects; D010879:Piperazines / Q000138:chemical synthesis / Q000494:pharmacology; D011719:Pyrazines / Q000138:chemical synthesis* / Q000494:pharmacology; D011789:Quantum Theory; D051381:Rats; D011985:Receptors, Serotonin / Q000187:drug effects; D012701:Serotonin / Q000502:physiology*; D013329:Structure-Activity Relationship; D014590:Uterine Contraction / Q000187:drug effects
D010879:Piperazines; D011719:Pyrazines; D011985:Receptors, Serotonin; D012701:Serotonin