Cross-protection of mice provided by active and passive immunization against experimental infections with virulent Proteus rettgeri and Providencia bacteria.
Immunization with Providencia and Proteus rettgeri Formalin-treated bacterial suspensions produced high levels of protection in mice against homologous and heterologous challenge. Mice were also cross-protected, but less effectively, by passive administration of rabbit type-specific antisera. The protective activity appeared to be due to an antigen common to strains of different O-serotypes. It was not detectable in agglutination reactions, and preliminary results indicate that it is thermostable, not being inactivated in its antibody binding capacity at 121 degrees C for 1 h.
D000818:Animals; D000907:Antibodies, Bacterial / Q000008:administration & dosage; D003429:Cross Reactions; D007110:Immunity, Active; D007112:Immunity, Maternally-Acquired; D007114:Immunization; D051379:Mice; D011511:Proteus / Q000276:immunology*; D011512:Proteus Infections / Q000276:immunology / Q000517:prevention & control*; D011532:Providencia / Q000276:immunology*
D000907:Antibodies, Bacterial