title: [Lactate dehydrogenase and Krebs cycle enzyme activity in rat liver during the growth of transplanted and spontaneous tumors].
abstract: Certain distinctions in the mouse and rat liver responses to transplanted and spontaneous tumours have been discovered at the initial periods of their growth. The most pronounced changes (the mosaic distribution of enzymatic activity in the lobe) are observed in the case of spontaneous tumours. Activities the Krebs cycle enzymes, especially of NAD-dependent enzymes are seen inhibited in the tumour-bearing liver at the terminal periods of growth of both spontaneous and transplanted tumours; lactate dehydrogenase activity increases (with the exception of mitochondrial lactate dehydrogenase in the rat liver with transplanted sarcomas).
mesh_terms: D000154:Aconitate Hydratase / Q000378:metabolism; D000230:Adenocarcinoma / Q000201:enzymology; D000818:Animals; D002279:Carcinoma 256, Walker / Q000201:enzymology; D005260:Female; D007521:Isocitrate Dehydrogenase / Q000378:metabolism; D007655:Ketoglutarate Dehydrogenase Complex / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008099:Liver / Q000201:enzymology*; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000201:enzymology; D051379:Mice; D009374:Neoplasms, Experimental / Q000201:enzymology*; D010088:Oxidoreductases / Q000378:metabolism*; D011817:Rabbits; D012513:Sarcoma, Experimental / Q000201:enzymology; D013045:Species Specificity; D013385:Succinate Dehydrogenase / Q000378:metabolism
chemical_list: D010088:Oxidoreductases; D007770:L-Lactate Dehydrogenase; D007521:Isocitrate Dehydrogenase; D007655:Ketoglutarate Dehydrogenase Complex; D013385:Succinate Dehydrogenase; D000154:Aconitate Hydratase
vernacular_title: Aktivnost' laktatdegidrogenazy i fermentov tsikla Krebsa v pecheni pri roste perevivaemykh i spontannykh opukholeĭ.