Early destruction of cytochrome P-450 in testis of carbon tetrachloride poisoned rats.
There is 20--36 percent decrease in the microsomal cytochrome P-450 (P450) content of the testes 3 or 6 h after CCl4 administration to Sprague--Dawley male rats. Irreversible binding of CCl4 metabolites to testicular microsomal lipids is observed as early as 3 h while CCl4 induced lipid peroxidation does not occur within the first 6 h of poisoning. Results suggest that reactive metabolites rather than lipid peroxidation is involved in P-450 destruction in the testes.
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000201:enzymology*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D008861:Microsomes / Q000201:enzymology; D010545:Peroxides / Q000378:metabolism; D051381:Rats; D013737:Testis / Q000201:enzymology* / Q000648:ultrastructure; D013997:Time Factors
D010545:Peroxides; D003577:Cytochrome P-450 Enzyme System