title: Intramuscular absorption of dihydroergotamine in man.
abstract: In order to prevent hypotension, 1.0 mg of dihydroergotamine (Vasogin) was injected intramuscularly to 10 patients 5 minutes before spinal anaesthesia. The peak plasma concentrations were measured by a radioimmunoassay as early as at 30 minutes after drug administration, indicating a fast intramuscular absorption. According to the plasma levels the drug has to be given 15-30 minutes before spinal anaesthia.
mesh_terms: D000042:Absorption; D000328:Adult; D000368:Aged; D000775:Anesthesia, Spinal / Q000009:adverse effects; D001794:Blood Pressure / Q000187:drug effects; D004087:Dihydroergotamine / Q000008:administration & dosage / Q000378:metabolism* / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007273:Injections, Intramuscular; D008875:Middle Aged; D013997:Time Factors
chemical_list: D004087:Dihydroergotamine