Acute phase of sarcoidosis with splenomegaly and hypercalcemia. Description of a case, including a report about splenectomy and the preparation and testing of a Kveim antigen from the spleen.
A young man had a mild, slightly progressive pulmonary sarcoidosis. After 4 years he developed an acute disease with splenomegaly, anemia, marked elevation of ESR, hypercalcemia and mild renal insufficiency. The anemia and ESR elevation disappeared after splenectomy, whereas the hypercalcemia still needs corticosteroid treatment. Attempts to withdraw this treatment resulted in recurrence of the hypercalcemia, but no other abnormalities. In contrast to other organs examined, the sarcoid tissue in the spleen revealed necrosis formation, consistent with a recent process. A Kveim antigen preparation from the spleen was less potent than antigen from mediastinal lymph nodes. It is suggested that the acute phase of the disease involved mainly the spleen. Speculations about the possible role of infectious agent(s) are put forward.
D000208:Acute Disease; D000740:Anemia / Q000209:etiology; D000941:Antigens; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D007731:Kveim Test; D008171:Lung Diseases / Q000150:complications* / Q000276:immunology; D008297:Male; D012507:Sarcoidosis / Q000150:complications* / Q000276:immunology; D012882:Skin Tests; D013154:Spleen / Q000276:immunology*; D013156:Splenectomy; D013163:Splenomegaly / Q000209:etiology*
D000941:Antigens