title: [Changes in the mitotic activity of corneal epithelial cells under the influence of pyruvic acid].
abstract: 92 specimens of rat's corneal epithelium were studied to estimate the effect of pyruvic acid on cell division characteristics. 0.1 M solution of pyruvic acid decreases the mitotic activity of rat corneal epithelium, the portion of prophase increasing the number of metaphase decreasing. These results support a hypothesis on the possible role of low molecular acceptors in the cell division regulation "in vivo", and suggests the effect of pyruvic acid both during the period prior to cell division, and the prophase-metaphase stage.
mesh_terms: D000818:Animals; D003315:Cornea / Q000166:cytology / Q000187:drug effects*; D003864:Depression, Chemical; D004847:Epithelial Cells; D008297:Male; D008938:Mitosis / Q000187:drug effects*; D011773:Pyruvates / Q000494:pharmacology*; D051381:Rats
chemical_list: D011773:Pyruvates
vernacular_title: Izmenenie mitoticheskoĭ aktivnosti épitelial'nykh kletok rogovitsy pod vliianiem pirovinogradnoĭ kisloty.