Thyroglobulin complementary DNA as a means to investigate congenital goiters with impaired thyroglobulin synthesis.
A congenital goiter with impaired thyroglobulin synthesis has been investigated for the presence of messenger RNA coding for thyroglobulin. Using complementary DNA to beef 33 S thyroglobulin mRNA as a probe, we have found that thyroglobulin related sequences are present in the goiter but at a concentration lower than in normal human thyroids. We conclude that the disease is not due to a complete deletion of thyroglobulin gene.
D000818:Animals; D002417:Cattle; D004247:DNA / Q000378:metabolism*; D004285:Dogs; D006041:Goats; D006042:Goiter / Q000151:congenital* / Q000235:genetics / Q000378:metabolism; D006801:Humans; D012333:RNA, Messenger / Q000378:metabolism; D013954:Thyroglobulin / Q000096:biosynthesis* / Q000235:genetics
D012333:RNA, Messenger; D004247:DNA; D013954:Thyroglobulin