title: Anatomical specificity within rat striatum for the dopaminergic modulation of DRL responding and activity.
abstract: The direct application of microgram quantities of crystalline dopamine, D-amphetamine, or scopolamine to the ventral anterior region of the neostriatum of rats decreased response efficiency on a 'differential reinforcement of low rate' 10 sec schedule of reinforcement. Similar applications to the dorsal globus pallidus or posterior striatum either did not alter or increased response efficiency. A comparison of dose-response functions for injections of dopamine in solution into ventral anterior, central and posterior striatum confirmed that only injections into ventral anterior striatum (VAS) decreased response efficiency on the DRL schedule. The same striatal map was found for the dopamine-induced increase in spontaneous locomotor activity in tilt boxes. It was concluded that dopaminergic transmission in ventral anterior striatum, in contrast to the other striatal and pallidal sites tested, is involved in the modulation of behavioral arousal.
mesh_terms: D000818:Animals; D003216:Conditioning, Operant / Q000187:drug effects*; D003342:Corpus Striatum / Q000033:anatomy & histology* / Q000187:drug effects; D003913:Dextroamphetamine / Q000494:pharmacology; D004298:Dopamine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005917:Globus Pallidus / Q000187:drug effects; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D012055:Reinforcement Schedule; D012601:Scopolamine / Q000494:pharmacology
chemical_list: D012601:Scopolamine; D003913:Dextroamphetamine; D004298:Dopamine