Hereditary myelopathy of Afghan hounds, a myelinolytic disease.
A disease described previously as hereditary necrotizing myelopathy and myelomalacia was studied in four Afghan hounds. Light and electron microscopic investigation revealed sieve-like degeneration of spinal white matter. Despite extensive spongiform degeneration of myelin that progressed to micro- and macro-cavitation, substantial numbers of axons were preserved. This canine myelopathy was compared and contrasted with various toxic/metabolic conditions including subacute combined degeneration.
D000818:Animals; D001369:Axons / Q000648:ultrastructure; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005260:Female; D008297:Male; D008854:Microscopy, Electron; D009186:Myelin Sheath / Q000648:ultrastructure; D013116:Spinal Cord / Q000648:ultrastructure; D013118:Spinal Cord Diseases / Q000662:veterinary*