Ga-67 and Fe-59 distributions in mice.
Tissue distributions of i.v.-injected Ga-67 citrate and [59Fe] ferric citrate were measured in normal mice and in lymphoid-tumor hosts. The study arose out of previously reported tissue-culture work showing marked transferrin stimulation of Ga-67 and Fe-59 uptakes by cultured cells from mouse lymphoid tumors. In vivo, however, no obvious correlation was found between Ga-67 and Fe-59 tissue distributions; indeed, Ga-67 showed high affinity for tumor tissue and low affinity for hemopoietic tissues, while for Fe-59 the reverse applied. Taken together, these comparisons of kinetics and distributions for Ga-67 and Fe-59 suggest that a tissue's avidity for Ga-67 is strongly influenced by other factors besides the cell population's capacity for transferrin interactions.
D000375:Aging; D000818:Animals; D002951:Citrates / Q000008:administration & dosage / Q000378:metabolism; D005290:Ferric Compounds / Q000008:administration & dosage / Q000378:metabolism; D005710:Gallium Radioisotopes / Q000008:administration & dosage / Q000378:metabolism*; D007275:Injections, Intravenous; D007504:Iron Radioisotopes / Q000008:administration & dosage / Q000378:metabolism*; D008223:Lymphoma / Q000378:metabolism; D051379:Mice; D009374:Neoplasms, Experimental / Q000378:metabolism; D014018:Tissue Distribution
D002951:Citrates; D005290:Ferric Compounds; D005710:Gallium Radioisotopes; D007504:Iron Radioisotopes