Effect of halothane on the rate of acid production, lactate production and pyruvate dehydrogenase activity of malignant hyperpyrexia human muscle.
The rates of acid production were compared in thin strips of muscle biopsy samples isolated from malignant hyperpyrexia and control vastus internus human muscle. Halothane doubled the rate of acid production by malignant hyperpyrexia susceptible muscle but had no effect on control samples. This increased rate of release of acid from muscle was not from lactate. In addition, the pyruvate dehydrogenase activity of both control and malignant hyperpyrexia muscle samples was not stimulated by halothane.
D000143:Acids / Q000378:metabolism*; D006221:Halothane / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D007773:Lactates / Q000096:biosynthesis*; D008305:Malignant Hyperthermia / Q000378:metabolism*; D009132:Muscles / Q000187:drug effects* / Q000378:metabolism; D011768:Pyruvate Dehydrogenase Complex / Q000378:metabolism*; D013997:Time Factors
D000143:Acids; D007773:Lactates; D011768:Pyruvate Dehydrogenase Complex; D006221:Halothane