[Effect of eserine on DNA synthesis in rat liver].
Incorporation of labelled precursors into total and nuclear DNA of liver tissue was inhibited after administration into animals of eserine at a dose 0.1--0.2 mg/100 g of body weight. Simultaneously, DNAase activity was increased and cholinesterase activity was inhibited in liver tissue. The DNA synthesis was inhibited in liver slices, if they were incubated with 2.10(-6) M eserine. The DNAase activity was unaltered in vitro. A cholinolytic compound metacin, pre-administered into the animals, was ineffective at dose of 1 mg/kg; it slightly decreased the effect of eserine at dose of 0.25 mg/kg.
D000109:Acetylcholine / Q000502:physiology; D000818:Animals; D002802:Cholinesterases / Q000378:metabolism; D004247:DNA / Q000096:biosynthesis*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010830:Physostigmine / Q000494:pharmacology*; D051381:Rats; D013936:Thymidine / Q000378:metabolism; D013941:Thymine / Q000378:metabolism
D004247:DNA; D010830:Physostigmine; D002802:Cholinesterases; D000109:Acetylcholine; D013941:Thymine; D013936:Thymidine
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