title: Experimental studies on human health effects of air pollutants. IV. Short-term physiological and clinical effects of nitrogen dioxide exposure.
abstract: Adult male volunteers were exposed to nitrogen dioxide (NO2) at 1.0 ppm in purified air under conditions simulating ambient photochemical smog exposures (2-hr exposure with intermittent light exercise at 31 degrees C and 35% relative humidity). Sham exposures to purified air alone served as controls. Exposure effects were assessed by pulmonary physiological tests and by a standardized clinical evaluation. No statistically physiological changes attributable to NO2 exposure were found except for a marginal loss in forced vital capacity after exposure on two successive days (1.5% mean decrease, P less than .05). Reported respiratory and other symptoms were slightly increased with exposure as compared to control, but the change was not significant. Short-term toxicity of NO2 at peak ambient concentrations appears to be substantially less than that of ozone in healthy people, but adverse NO2 effects in diseased people or in long-term exposures cannot be ruled out at present.
mesh_terms: D000328:Adult; D000393:Air Pollutants / Q000009:adverse effects*; D004782:Environmental Health; D006801:Humans; D008875:Middle Aged; D009585:Nitrogen Dioxide / Q000009:adverse effects*; D010865:Pilot Projects; D012129:Respiratory Function Tests; D013997:Time Factors
chemical_list: D000393:Air Pollutants; D009585:Nitrogen Dioxide