Acetylation phenotype in rheumatoid arthritis.
The acetylation rate of INH was studied in 39 patients with RA; 20 patients with cardiac arrhythmia served as controls. Statistically, no significant difference was observed between the groups. The percentages of rapid acetylators in the RA and control groups were higher (59 and 55%, respectively) than the reported incidence in the Finnish population, 44% (11). The polymorphic acetylation phenotype was not correlated with either clinical parameters of RA or with sensitivity to gold salts.
D000107:Acetylation; D001145:Arrhythmias, Cardiac / Q000097:blood / Q000378:metabolism; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000378:metabolism*; D006207:Half-Life; D006801:Humans; D007538:Isoniazid / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D010641:Phenotype
D007538:Isoniazid