Immune reactivity of Visna virus-inoculated mice.
Visna virus inoculation of mice before immunization with unrelated antigens caused suppression of humoral and cell-mediated immune responses. The immunosuppressive effect was dependent on the virus dose and time of administration. The number of "background" antibody-producing spleen cells increased slightly after inoculation of Visna virus. Heat treatment of Visna virus abolished its immunosuppressive effect. Replication of Visna virus in mice seemed to be a prerequisite for its immunomodulating effect.
D000818:Animals; D000917:Antibody Formation; D003877:Dermatitis, Contact / Q000276:immunology; D007111:Immunity, Cellular; D007156:Immunologic Memory; D007165:Immunosuppression Therapy; D007372:Interferons / Q000378:metabolism; D008213:Lymphocyte Activation; D051379:Mice; D012190:Retroviridae / Q000276:immunology*; D014777:Virus Diseases / Q000276:immunology*
D007372:Interferons