[Comparative assessment of circulatory and respiratory maintenance by hemoglobin dissolved in plasma and contained in erythrocytes].
Basic values of blood circulation and respiration were compared in two groups of cats. The blood of group I animals was replaced by a 8% solution of human Hb completely free of stroma and procoaglulant activity. In group II animals the blood was diluted with polyglucine to the Hb level of 8 g%. The solution is well saturated in the lungs and releases O2 to tissues, but much less than Hb contained in red cells. The dissolved Hb did not completely meet the requirements of the organism in oxygen with the resultant hypoxia. Moderate anemic hypoxia caused by blood dilution with polyglucine was easily compensated. Hb solution can be considered as the basis or the first stage in the production of an oxygen carrier blood substitute.
D000818:Animals; D001775:Blood Circulation; D001783:Blood Flow Velocity; D001794:Blood Pressure; D002415:Cats; D002496:Central Venous Pressure; D004912:Erythrocytes / Q000502:physiology*; D006454:Hemoglobins / Q000502:physiology*; D010100:Oxygen / Q000097:blood; D010952:Plasma Substitutes; D012119:Respiration
D006454:Hemoglobins; D010952:Plasma Substitutes; D010100:Oxygen
Sravnitel'naia otsenka obespecheniia krovoobrashcheniia i dykhaniia gemoglobimon, rastvorennym v plazme i zakliuchennym v éritrotsitakh.