Influence of beta-amino-propionitrile on elastogenesis in the chick embryo (light and electron microscopic study).
Beta-amino-propionitrile was administered in a single dose into the chorioallantoic cavity of 14 days old chick embryos. The effects on the elastic fibre production were examined on the 3rd or 7th day following the injection. By light microscopy dissecting aneurysm, aortic ruptures were found. The elastic fibres were poorly developed and exhibited irregularities and structural anomalies. Electron microscopically we observed reduction of the number or complete absence of elastic aggregates and fibres. The elastic structures exhibited abnormal phosphotungstic acid binding. This was considered as a sign for disturbances in the development of cross linkages and in the incorporation of elastin into the elastic fibres.
D000629:Aminopropionitrile / Q000494:pharmacology*; D000818:Animals; D001011:Aorta / Q000648:ultrastructure; D001014:Aortic Aneurysm / Q000139:chemically induced / Q000473:pathology; D001019:Aortic Rupture / Q000139:chemically induced / Q000473:pathology; D002642:Chick Embryo; D004547:Elastic Tissue / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D004549:Elastin / Q000378:metabolism; D010772:Phosphotungstic Acid / Q000378:metabolism
D010772:Phosphotungstic Acid; D000629:Aminopropionitrile; D004549:Elastin