Unrepaired DNA strand breaks in irradiated ataxia telangiectasia lymphocytes suggested from cytogenetic observations.
It is suggested here that the unusually high level of radiation-induced chromosome and chromatid-type aberrations in cells from patients with ataxia telangiectasia, compared with normals, is due to a significantly increased fraction of unrepaired double and single strand breaks. A hypothesis is proposed to explain how unrepaired and misrepaired DNA single or double strand breaks might be the basic lesion leading to the typical chromosome aberrations seen following X-irradiation of both normal or AT cells.
D001260:Ataxia Telangiectasia / Q000235:genetics*; D002478:Cells, Cultured; D002842:Chromatids / Q000528:radiation effects*; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000528:radiation effects; D004247:DNA / Q000528:radiation effects; D004260:DNA Repair; D004277:DNA, Single-Stranded / Q000528:radiation effects; D008214:Lymphocytes / Q000528:radiation effects* / Q000648:ultrastructure; D014965:X-Rays
D004277:DNA, Single-Stranded; D004247:DNA