HLA and kidney stone disease.
Normocalcemic patients with recurring kidney stones were HLA typed. 54 patients with an idiopathic high urinary excretion of calcium but without signs of renal tubular defect showed a B27 phenotype frequency which was more than twice that of the controls and a CW1 frequency that was doubled. After correction for the number of tested HLA specificities the increase was not significant. 35 patients with renal tubular acidosis and 16 patients with no metabolic diagnosis had no deviant HLA antigen distribution.
D000141:Acidosis, Renal Tubular / Q000235:genetics; D000328:Adult; D000368:Aged; D002118:Calcium / Q000378:metabolism / Q000652:urine; D005260:Female; D005787:Gene Frequency; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D007408:Intestinal Absorption; D007669:Kidney Calculi / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012008:Recurrence; D012306:Risk
D006680:HLA Antigens; D002118:Calcium