Synergism between tetracycline and amphotericin B in experimental amoebic meningoencephalitis.
The efficacy of tetracycline and amphotericin B in the treatment of primary amoebic meningoencephalitis was studied by means of a mouse model. The results showed marked synergism between these two drugs. Mice who recieved 50 microgram amphotericin B daily succumbed to the infection with only 28.6% survival compared to 0% in untreated controls. In contrast, survival percentage was increased to 66.7% and 84.6% in mice receiving the combined dosage schedule of 50 microgram amphotericin B with 2 tetracycline, and 50 microgram amphotericin B with 3 mg tetracycline, respectively. The finding of synergism between tetracycline and amphotericin may provide a better means for the treatment of this disease.
D000562:Amebiasis / Q000188:drug therapy* / Q000401:mortality; D000666:Amphotericin B / Q000627:therapeutic use*; D000818:Animals; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D008297:Male; D008590:Meningoencephalitis / Q000188:drug therapy* / Q000401:mortality; D051379:Mice; D008807:Mice, Inbred BALB C; D013752:Tetracycline / Q000627:therapeutic use*
D000666:Amphotericin B; D013752:Tetracycline