title: Chemical modifications of tyrosyl residue(s) and action of human-fibroblast interferon.
abstract: Partially purified and purified human fibroblastoid interferon were iodinated and nitrated under experimental conditions in which the most likely amino acyl residue modified was tyrosine(s). The modification resulted in a loss of human interferon activity suggesting that tyrosyl residue(s) is associated with the antiviral action of human interferon.
mesh_terms: D002460:Cell Line; D005033:Ethylmaleimide; D006801:Humans; D007372:Interferons / Q000302:isolation & purification / Q000494:pharmacology; D013774:Tetranitromethane; D014443:Tyrosine
chemical_list: D014443:Tyrosine; D007372:Interferons; D013774:Tetranitromethane; D005033:Ethylmaleimide