Aging of soman-inhibited acetylcholinesterase: inhibitors and accelerators.
The influence of 27 possible effectors, mostly bispyridinium salts, upon the dealkylation (aging) of soman-inhibited acetylcholinesterase (acetylcholine hydrolase, EC 3.1.1.7) was examined at pH 7.6 and 25 degrees C. In the absence of effectors, the rate constant of the aging process was 4.0. 10(-2) min-1. At 2 mM, the strongest inhibitor reduced the rate to 0.8. 10(-2) min-1, whereas it was raised to 8.2. 10(-2) min-1 by the most potent accelerator.
D000110:Acetylcholinesterase / Q000378:metabolism; D002800:Cholinesterase Inhibitors; D003640:Dealkylation; D004355:Drug Stability; D004789:Enzyme Activation; D007700:Kinetics; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D011726:Pyridinium Compounds / Q000494:pharmacology*; D012999:Soman / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D002800:Cholinesterase Inhibitors; D009943:Organophosphorus Compounds; D011726:Pyridinium Compounds; D012999:Soman; D000110:Acetylcholinesterase