Clobazam--a new hypnotic?
1 A double-blind randomized trial to compare the relative efficacy of the 1,5-benzodiazepine, clobazam, the 1,4-benzodiazepine nitrazepam, and placebo as hypnotics was carried out. 2 A preference technique was used and the analyses were performed sequentially. 3. The results confirmed that nitrazepam was superior to placebo as a hypnotic but failed to show that clobazam was superior to either placebo or nitrazepam in a ratio of 2:1. Thus, it seems likely that the hypnotic properties of clobazam are minimal. 4 Clobazam is not suitable for use as a hypnotic in hospitalized patients.
D000328:Adult; D000367:Age Factors; D000368:Aged; D001570:Benzodiazepinones / Q000494:pharmacology*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives; D008297:Male; D008875:Middle Aged; D009567:Nitrazepam / Q000494:pharmacology; D010919:Placebos
D001570:Benzodiazepinones; D006993:Hypnotics and Sedatives; D010919:Placebos; D009567:Nitrazepam