Proliferation of bone marrow and thymus cells and increased osteoclasia after antigenic challenge in rats.
Injection of a single dose of an antigenic substance (sheep red blood corpuscles) in young rats results in a significant rise in the number of mitoses in bone marrow (and in thymus) and in addition a significant rise in the number of osteoclasts in the metaphyses of the ribs. This increased osteoclasia appears 1 day after the peak values of the bone marrow and thymus mitoses. This and earlier investigations make it probable that there is a causal relationship between bone marrow stimulation and increased osteoclasia.
D000818:Animals; D000941:Antigens / Q000008:administration & dosage; D001854:Bone Marrow Cells; D002452:Cell Count; D002455:Cell Division; D003078:Colchicine / Q000494:pharmacology; D004912:Erythrocytes; D008938:Mitosis / Q000187:drug effects; D010010:Osteoclasts; D051381:Rats; D012756:Sheep; D013950:Thymus Gland / Q000166:cytology*
D000941:Antigens; D003078:Colchicine