The c-wave of the human electroretinogram in central retinal artery occlusion.
The pigment epithelium-receptor complex, which is supplied from the choroidal circulation, is the main source of the c-wave of the ERG. Occlusion of the central retinal artery (OCRA), which causes serious damage to the inner retinal layers, should therefore not primarily be expected to affect the c-wave amplitude. Nevertheless, conflicting reports of increased, decreased and unchanged c-waves have appeared in the literature. In the present study on four patients with OCRA the affected eyes showed diminished b- and c-waves. On the other hand, both the a-wave and the trough between the b- and c-waves were accentuated in the diseased eyes. Experiments in progress on Cynomolgus monkeys with experimentally induced unilateral OCRA show similar results.
D000368:Aged; D001157:Arterial Occlusive Diseases / Q000175:diagnosis* / Q000503:physiopathology; D004596:Electroretinography; D006801:Humans; D008875:Middle Aged; D010775:Photic Stimulation; D010857:Pigment Epithelium of Eye / Q000503:physiopathology; D012160:Retina / Q000503:physiopathology*; D012161:Retinal Artery; D012164:Retinal Diseases / Q000175:diagnosis / Q000503:physiopathology