title: Attempts at simulating evolution by a computer: I. evolution of proteins under prebiotic conditions.
abstract: The effect of random mutations of five identical pentapeptides that have been inserted arbitrarily along a 100 amino acid-long protein chain has been studied by computer simulation. The method used was the application of mutation probability matrix for 2 PAMs of Dayhoff (1972) repeatedly to obtain the desired length of time. The results indicated that, given sufficient length of time, even the identical peptides could become drastically altered and in order to recognise them as stemming from the same origin one has to use reasonable statistical significance thresholds.
mesh_terms: D000595:Amino Acid Sequence; D005075:Biological Evolution; D003201:Computers; D004463:Ecology; D008954:Models, Biological; D010455:Peptides; D011506:Proteins / Q000235:genetics*; D014357:Trypsin
chemical_list: D010455:Peptides; D011506:Proteins; D014357:Trypsin