title: Synthesis of some aromatic prostaglandin analogs.
abstract: Some aromatic prostaglandin analogs, having a benzene (2a, 2b) and a dimethoxybenzene (1) ring in place of the cyclopentane moiety, have been synthesized. The key intermediates in the syntheses were lactols 9 and 5, which were elaborated to the final products via two olefination reactions. Compound 2b was twice as potent as phenylbutazone and nine times as potent as aspirin in inhibiting prostaglandin synthetase activity.
mesh_terms: D008968:Molecular Conformation; D011465:Prostaglandins, Synthetic / Q000138:chemical synthesis*
chemical_list: D011465:Prostaglandins, Synthetic