A comparative study of the influence of malignant tumor on host metabolism in mice and man: evaluation of an experimental model.
Metabolic alterations in skeletal muscles and liver tissue from cancer patients were compared with corresponding alterations in mice (C-57) with sarcoma (MCG-101). In tumor-bearing man and mice similar changes in enzyme activities and in protein turnover were found. Glycolytic and oxidative enzyme activities were decreased in skeletal muscle tissue. Tumor-associated increase in lysosomal enzyme activities was found in both species. Leucine was incorporated into skeletal muscle proteins at a lower rate and into hepatic proteins at a higher rate in both species with malignant tumor. In tumor-bearing mice ribosome profiles from skeletal muscle, heart muscle and liver showed a preponderance of slowly sedimenting units of polyribosomes suggesting that initiation of protein synthesis may be a rate limiting step. The metabolic host reactions in tumor-bearing mice were similar to those in cancer patients implying that experimental tumors are relevant to use for analysis of mechanisms behind the development of cancer cachexia in man.
D000328:Adult; D000368:Aged; D000818:Animals; D002100:Cachexia / Q000209:etiology; D004195:Disease Models, Animal; D005260:Female; D006019:Glycolysis; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008875:Middle Aged; D009132:Muscles / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism; D009363:Neoplasm Proteins / Q000378:metabolism; D009369:Neoplasms / Q000150:complications / Q000378:metabolism*; D009748:Nutrition Disorders / Q000378:metabolism; D012334:RNA, Neoplasm / Q000378:metabolism; D012513:Sarcoma, Experimental / Q000378:metabolism*
D009363:Neoplasm Proteins; D012334:RNA, Neoplasm