[Interrelationship between delayed hypersensitivity and macrophage resistance to infection by influenza virus].
Interaction between the influenza virus and the sensitized cells, depending on the number of animal immunizations, was studied on a model of mouse peritoneal macrophages. The maximal suppression of the macrophage migration was observed in 2 weeks in 21% of mice immunized once, and in 35% of mice immunized twice. Three hours after the infection of the macrophage culture with the influenza virus in a dose of 10 EID50 there were revealed in the cells obtained from mice immunized once 70%, and from mice immunized twice 8% of the infectious virus in comparison with the intact macrophages. There was a direct relationship between the delayed hypersensitivity determined in the macrophage inhibition migration test and the macrophage resistance to the infection with the influenza virus.
D000818:Animals; D002464:Cell Migration Inhibition; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D066298:In Vitro Techniques; D009980:Influenza A virus; D007252:Influenza Vaccines / Q000008:administration & dosage; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009976:Orthomyxoviridae Infections / Q000276:immunology / Q000517:prevention & control*; D013997:Time Factors; D014611:Vaccination
D007252:Influenza Vaccines
Vzaimosviaz' mezhdu zamedlennoĭ giperchuvstvitel'nost'iu i rezistentnost'iu makrofagov k zarazheniiu virusom grippa.