Immunological recovery after measles.
Twenty-two children with measles were studied at the stage of the rash and 6 weeks later, and results compared with matched controls. The total lymphocyte count and lymphocyte subpopulations with T- and B-cell markers and those with absence of both markers (null cells) were significantly below control levels in the acute phase. At 6 weeks the B-cell and null-cell counts were still significantly diminished. The function of T cells assessed by 14C uptake of phytohaemagglutinin-stimulated lymphocytes and the delayed skin hypersensitivity reaction to dinitrochlorobenzene was impaired during the acute stage, and this persisted for 6 weeks. Over the 6 weeks of study there was a small but significant rise in serum IgG, IgM and complement factors.
D002648:Child; D002675:Child, Preschool; D003165:Complement System Proteins / Q000032:analysis; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007165:Immunosuppression Therapy; D007223:Infant; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D008214:Lymphocytes; D008297:Male; D008457:Measles / Q000276:immunology*; D010835:Phytohemagglutinins / Q000494:pharmacology; D012882:Skin Tests; D013997:Time Factors
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D010835:Phytohemagglutinins; D003165:Complement System Proteins