title: [Effect of various non-radioactive and radioactive chemical compounds on the structure of the spleen].
abstract: Dynamical changes in the spleen of mice and rats were studied morphometrically and electron microscopically when the animals were given in drinking water radionucleotides in small concentrations (137Cs, 226Ra, 89Sr, 65Zn, Pb(NO3)2, BeCl2, hexamethyleniamine, methylmercurchloride) for 1-2 years. Total doses obtained for a year were 0.3-100 rad. Reactive reconstruction of the organ under radioactive and chemical effects was stated to proceed in three directions: a) hyperplasy of lymphoid tissue; b) enhanced plasmocytogenesis; c) hyperplasy of extramedullar hemopoiesis. Sequence in the appearance of these reactions and doses which produced them were different for every compound. In 1-2 years at large doses (160-200 rad) atrophy, amyloid degeneration of the spleen or signs of leukemia were observed. Disturbance of intercellular contacts and of intracellular regeneration was demonstrated electron microscopically.
mesh_terms: D000818:Animals; D002588:Cesium Radioisotopes; D003959:Diamines / Q000008:administration & dosage / Q000494:pharmacology*; D008767:Methylmercury Compounds / Q000494:pharmacology*; D051379:Mice; D008854:Microscopy, Electron; D011868:Radioisotopes / Q000008:administration & dosage*; D011883:Radium; D051381:Rats; D013154:Spleen / Q000187:drug effects / Q000528:radiation effects / Q000648:ultrastructure*; D013326:Strontium Radioisotopes; D015037:Zinc Radioisotopes
chemical_list: D002588:Cesium Radioisotopes; D003959:Diamines; D008767:Methylmercury Compounds; D011868:Radioisotopes; D013326:Strontium Radioisotopes; D015037:Zinc Radioisotopes; D011883:Radium
vernacular_title: Vliianie nekotorykh neradioaktivnykh i radioaktivnykh khimicheskikh soedineniĭ na strukturu selezenki.