Simultaneous treatment of portal hypertension and hepatic cirrhosis by splenohepatoplasty.
A study was done on the action of splenohepatoplasty upon intrahepatic and prehepatic portal hypertension. Portal hypertension was induced Wistar rats following the establishment of cirrhotic conditions. Hepatic cirrhosis was obtained in these rats by an oral, daily dose of tioacetamide during a four and five month period. Prehepatic hypertension was produced in dogs by the installation of a rubber cylinder, completely covered by cellophane paper, around the trunk of the vena porta. This procedure brought about a progressive compression of the vena porta. The application of splenoheptoplasty is a highly valuable treatment for portal hypertension as a derivative system and for intrahepatic portal hypertension as a derivative regenerative system.
D000081:Acetamides / Q000009:adverse effects; D000818:Animals; D004285:Dogs; D006975:Hypertension, Portal / Q000473:pathology / Q000601:surgery*; D008099:Liver / Q000601:surgery*; D008102:Liver Circulation; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000473:pathology / Q000601:surgery*; D051381:Rats; D013154:Spleen / Q000098:blood supply / Q000601:surgery*; D014690:Venous Pressure
D000081:Acetamides