A diffuse pustular eruption associated with ulcerative colitis.
Two patients each with a two-year history of chronic ulcerative colitis developed, over a 24- to 48-hour period, painful pustules involving the skin and oral mucosa. The pustular eruption was associated with a severe exacerbation of the colitis. Culture of the lesions and of the blood failed to reveal an infectious cause for the eruption. Histologic study of a pustule in case 2 revealed suppurative folliculitis. The lesions subsided rapidly in case 1 when intravenous hydrocortisone and intravenous and intramuscular antibiotics were administered, and further resolution occurred after colectomy. A similar rapid resoultion of the pustules occurred in case 2 after initiation of treatment with intramuscular cortisone acetate and antibiotics and with colectomy. This pustular eruption may represent a variant of pyoderma gangrenosum.
D000328:Adult; D003093:Colitis, Ulcerative / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000209:etiology / Q000473:pathology; D009061:Mouth Mucosa / Q000473:pathology; D011711:Pyoderma / Q000209:etiology / Q000473:pathology; D012871:Skin Diseases / Q000209:etiology* / Q000473:pathology; D012883:Skin Ulcer / Q000209:etiology / Q000473:pathology