The identification of eight hydroxylated metabolites of etidocaine by chemical ionization mass spectrometry.
1. Eight hydroxylated metabolites of etidocaine have been identified in urine of man by g.l.c.-chemical ionization mass spectrometry, using methane and a mixture of methane and deuterium oxide as reactant gases. 2. The metabolites identified were N-(2,6-dimethyl-3- and 4-hydroxyphenyl-)-2-(N,N-ethylpropylamino)butyramides, N-(2,6-dimethyl-3- and 4-hydroxyphenyl)-2-aminobutyramides, N-(2,6-dimethyl-3- and 4-hydroxyphenyl)-2-(N-ethylamino)butyramides, and N-(2,6-dimethyl-3- and 4-hydroxyphenyl)-2-(N-propylamino)butyramides. 3. The eight metabolites represent about 10% of the oral dose of etidocaine.
D000083:Acetanilides / Q000378:metabolism; D001711:Biotransformation; D002849:Chromatography, Gas; D005041:Etidocaine / Q000378:metabolism* / Q000652:urine; D006801:Humans; D006900:Hydroxylation; D008297:Male; D013058:Mass Spectrometry / Q000379:methods
D000083:Acetanilides; D005041:Etidocaine