[Effect of Ca2+ and gamma-aminobutyric acid on glutamate and glutamine oxidation by rat brain synaptosomes].
It was shown in vitro that Ca2+ addition induced inhibition of the synaptosomal respiration with glutamate and glutamine. The presence of GABA in the medium increased the inhibitory effect of Ca2+ on glutamine oxidation, but not on glutamate. GABA, by itself, had no influence on both glutamate and glutamine oxidation.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure*; D002118:Calcium / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005970:Glutamate Synthase / Q000378:metabolism; D005971:Glutamates / Q000378:metabolism*; D005972:Glutaminase / Q000378:metabolism; D005973:Glutamine / Q000378:metabolism*; D010084:Oxidation-Reduction; D051381:Rats; D013574:Synaptosomes / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D005971:Glutamates; D005973:Glutamine; D005680:gamma-Aminobutyric Acid; D005970:Glutamate Synthase; D005972:Glutaminase; D002118:Calcium
Vliianie Ca2+ i gamma-aminomaslianoĭ kisloty na okislenie glutamata i glutamina sinaptosomami golovnogo mozga krys.