Norepinephrine-induced acute renal failure: a reversible ischemic model of acute renal failure.
The present study has defined conditions whereby a reversible form of ischemia-induced ARF can be produced in the dog. Unlike previous studies [9-11] which examined the acute phase of NE-induced ARF, this study demonstrates the feasibility of using the model for the longitudinal study of ARF. Such a model may be useful in studying the pathologic and physiologic changes which occur during different phases of ARF. Perhaps most important, this model should also provide a setting in which treatment measures, either prophylactic or therapeutic for ARF, can be examined.
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000818:Animals; D003404:Creatinine / Q000097:blood / Q000652:urine; D004195:Disease Models, Animal; D004285:Dogs; D007511:Ischemia / Q000139:chemically induced*; D007668:Kidney / Q000098:blood supply*; D007677:Kidney Function Tests; D009392:Nephrectomy; D009638:Norepinephrine / Q000009:adverse effects*
D003404:Creatinine; D009638:Norepinephrine