[Problem of autonomy of adrenal cortex adenomas of different histological structures in Cushing's syndrome].
The authors analyzed the results of examination of 69 patients operated on for Itsenko-Cushing's syndrome (ICS); in 32 cases tumours of the adrenal cortex were revealed during the operation. Two histological forms of adenoma of the adrenal cortex were distinguished, i.e. adenomas of mono- and polymorphous structure. Increased background urinary excretion of 17-oxycorticosteroids (17-OCS) in patients with ICS suffering from tumours of polymorphous structure persisted at the former level or increased in the tests with 8 mg of dexamethazone (DMZ). The character of tests with 8 mg of DMZ in patients with ICS having adenomas of monomorphous structure was analogous to such in patients with ICS, but without any adrenal gland tumours--urinary 17-OCS excretion was either decreased or suppressed by 50 or more per cent of the initial level. A suggestion is put forward on functional dependence of the adrenal cortex of monomorphous structure on the hypothalamo-hypophysial control.
D000236:Adenoma / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D000293:Adolescent; D000302:Adrenal Cortex / Q000503:physiopathology; D000306:Adrenal Cortex Neoplasms / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D000310:Adrenal Gland Neoplasms / Q000503:physiopathology*; D000328:Adult; D000368:Aged; D003480:Cushing Syndrome / Q000150:complications / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007031:Hypothalamus / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010902:Pituitary Gland / Q000503:physiopathology
Problema avtonomnosti adenom kory nadpochechnikov razlichnogo gistologicheskogo stroeniia u bolńykh s sindromom Itsenko-Kushinga.