Production of cyclochlorotine and a new metabolite, simatoxin, by Penicillium islandicum Sopp.
Production of the hepatotoxin cyclochlorotine by Penicillium islandicum was studied under a variety of fermentation conditions. The best system for production was agitated red wheat. A thin-layer chromatographic method was developed for the detection of this cyclic polypeptide. These experiments have resulted in the isolation of a new toxic metabolite, which we call simatoxin.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D003470:Culture Media; D005285:Fermentation; D008099:Liver / Q000187:drug effects; D009183:Mycotoxins / Q000096:biosynthesis* / Q000302:isolation & purification / Q000633:toxicity; D010407:Penicillium / Q000378:metabolism*; D010456:Peptides, Cyclic / Q000096:biosynthesis* / Q000302:isolation & purification / Q000633:toxicity; D051381:Rats; D014908:Triticum
D003470:Culture Media; D009183:Mycotoxins; D010456:Peptides, Cyclic; C018925:chloropeptide