title: Protection of the ischaemic myocardium by glucose-insulin-potassium infusion assessed by ventricular function and electron microscopy.
abstract: The protective effect of GIK infusion on the ischaemic myocardium was assessed by isovolumic function tests and electron microscopy. There were two control groups, group 1 hearts underwent 2 hours of continous normothermic cross-perfusion and group 2 hearts endured 2 hours of ischaemia. Group 3 hearts were administered GIK solution prior to ischaemic arrest. The group 3 hearts showed less loss of contractile force and contractile velocity from the ischaemic period compared to group 2 hearts, but no benfit was shown in terms of compliance. Electron microscopic examination showed slightly less damage in the group 3 hearts compared to group 2 hearts. Group 1 hearts maintained better function than either of the other two groups. Ultrastructure was not examined in group 1 hearts. A slight protective effect of GIK on the ischaemic myocardium was thus confirmed.
mesh_terms: D000818:Animals; D001794:Blood Pressure; D003187:Compliance; D003327:Coronary Disease / Q000473:pathology / Q000517:prevention & control*; D004285:Dogs; D005947:Glucose / Q000008:administration & dosage*; D006321:Heart / Q000503:physiopathology; D006352:Heart Ventricles / Q000503:physiopathology / Q000648:ultrastructure; D007328:Insulin / Q000008:administration & dosage*; D009200:Myocardial Contraction; D009206:Myocardium / Q000648:ultrastructure; D011183:Postoperative Complications / Q000517:prevention & control; D011188:Potassium / Q000008:administration & dosage*
chemical_list: D007328:Insulin; D005947:Glucose; D011188:Potassium