Correlation between cytological and morphogenetic effects of acute X-irradiation of preimplantation mouse embryos cultured in vitro.
Inhibition of cavitation by acute X-irradiation of 2-cell stage eggs was due to the early killing of the cells. Eggs in which cavitation did take place had a smaller number of cells due mainly to mitotic delay, leading to lack of inner cell mass (ICM) and its derivatives in further development. A similar effect is responsible for the inhibition of ICM formation after irradiation of morulae.
D000818:Animals; D002452:Cell Count / Q000528:radiation effects; D002467:Cell Nucleus / Q000528:radiation effects; D004477:Ectogenesis; D004622:Embryo, Mammalian / Q000166:cytology / Q000528:radiation effects*; D047108:Embryonic Development; D005260:Female; D051379:Mice; D011247:Pregnancy