title: Intracutaneous herniation of fat in connection with microangiopathia diabetica.
abstract: Three women with diabetes mellitus presented an unusual change in the skin on the distal and acral parts of the extremities, most distinctly on the upper surface of the hands. The surface was raised in small cushions but had the colour of intact skin. The skin felt doughy and swolen on palpation but there was no oedematous pitting. It had been suspected earlier that these skin changes indicated myxoedema or heart disease and the patients had been treated with diuretics. In all three cases, however, histological examinations revealed a more or less reduced, atrophic dermis with here and there an appreciable dislocation of the subcutaneous layer of fat, which with the sweat glands formed an intracutaneous herniation up against the epidermis. These histological changes explained the clinical picture of cushions in the skin. As these patients had diabetes mellitus and the histological picture also included vascular changes of the type associated with a diabetic microangiopathy, it is considered that this form of intradermal herniation of fat is yet another skin change which may be elicited by diabetes mellitis.
mesh_terms: D000273:Adipose Tissue / Q000473:pathology; D000368:Aged; D003327:Coronary Disease / Q000150:complications; D003925:Diabetic Angiopathies / Q000150:complications* / Q000473:pathology; D005260:Female; D006547:Hernia / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000209:etiology* / Q000473:pathology; D013545:Sweat Glands / Q000473:pathology