Plasma levels, half-life values, and correlation with physiologic assays for growth and immunity.
Plasma prednisolone levels have been measured hourly in children receiving a single dose of oral prednisone. Peak prednisolone levels occurred one to two hours after ingestion; half-life studies gave a mean value of 132 minutes in most children. Some children had marked variability in absorption and metabolism of prednisone. Somatomedin activity and cell-mediated immunity were inhibited by plasma prednisolone values which were achieved by single doses of prednisone of 0.5 mg/kg or higher. Monitoring prednisolone levels may be of value in identifying those children who accumulate excessively high levels on moderate dosage regimens.
D000284:Administration, Oral; D000293:Adolescent; D000308:Adrenocortical Hyperfunction / Q000188:drug therapy; D001249:Asthma / Q000188:drug therapy; D001682:Biological Availability; D002648:Child; D002675:Child, Preschool; D003424:Crohn Disease / Q000188:drug therapy; D003882:Dermatomyositis / Q000188:drug therapy; D005260:Female; D006207:Half-Life; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy; D008297:Male; D009404:Nephrotic Syndrome / Q000188:drug therapy; D011239:Prednisolone / Q000008:administration & dosage / Q000097:blood* / Q000378:metabolism / Q000627:therapeutic use; D013002:Somatomedins / Q000097:blood
D013002:Somatomedins; D011239:Prednisolone