title: Effect of salicylic acid on articular cartilage in organ culture.
abstract: An organ culture system was used to study the metabolic effects of exposure of articular cartilage to increasing concentrations of salicylic acid. It was shown that concentration of salicylate above 1 mM inhibited the incorporation of 35S-sulphate into proteoglycans and at concentrations above 2.5 mM inhibited the incorporation of 3H-proline into collagen. Long-term exposure of the cartilage to salicylic acid at concentrations above 1 mM had a toxic effect on both proteoglycan and collagen synthesis.
mesh_terms: D000818:Animals; D002358:Cartilage, Articular / Q000187:drug effects / Q000196:embryology / Q000378:metabolism*; D002417:Cattle; D003094:Collagen / Q000096:biosynthesis / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D009924:Organ Culture Techniques; D011392:Proline / Q000378:metabolism; D011509:Proteoglycans / Q000096:biosynthesis / Q000378:metabolism; D012459:Salicylates / Q000008:administration & dosage / Q000633:toxicity*; D013431:Sulfates / Q000378:metabolism; D013997:Time Factors
chemical_list: D011509:Proteoglycans; D012459:Salicylates; D013431:Sulfates; D003094:Collagen; D011392:Proline