3,3'-Iminodipropionitrile induced centrifugal segmental demyelination and onion bulb formation.
Centrifugal segmental demyelination extended from the proximal to the distal portion, and onion bulb formation in the extraspinal ventral root occurred following the axonal lesion of the intraspinal ventral root induced by 3,3'-iminodipropionitrile. These results suggest that axonal factors may be responsible to segmental demyelination and onion bulb formation.
D000818:Animals; D001369:Axons / Q000648:ultrastructure; D003711:Demyelinating Diseases / Q000139:chemically induced / Q000473:pathology*; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000648:ultrastructure*; D009570:Nitriles; D051381:Rats; D013126:Spinal Nerve Roots / Q000473:pathology*
D009570:Nitriles; C008110:3,3'-iminodipropionitrile