[Cardiac side-effects of oesophago-gastro-duodenoscopy in relation to premedication (author's transl)].
The electrocardiogram was monitored in 100 patients undergoing oesphago-gastro-duodenoscopy. Premedication differed: 25 patients each were given either (Group I) atropine 0.5 mg, hyoscine-N-butylbromide 20 mg, and diazepam 5 mg, or (Group II) hyoscine-N-butyl-bromide 20 mg and diazepam 5 mg, or (Group II) diazepam 5 mg and glucagon 0.2 mg, or (Group IV) only diazepam 5 mg intravenously. After injection of the parasympatholytic drugs (Groups I and II) there was a significantly higher heart rate duringthe entire length of the examination than in groups III and IV. Nine of the ten cases of ascending S-T depression were found in Groups I and II, while descending (ischaemic) S-T changes occurred equally frequently in patients of all four groups. Two of the three more serious arrhythmias were registered after atropine. Since parasympatholytic drugs fail to inhibit arrhythmias and ST-T changes, while accentuating the rise in heart rate, it is recommended that premedication for oesophago-gastro-duodenoscopy should not include such drugs.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001145:Arrhythmias, Cardiac / Q000209:etiology*; D001285:Atropine / Q000009:adverse effects; D002086:Butylscopolammonium Bromide / Q000009:adverse effects; D003975:Diazepam / Q000009:adverse effects; D004386:Duodenum; D004724:Endoscopy / Q000009:adverse effects*; D004945:Esophagoscopy / Q000009:adverse effects*; D005260:Female; D005773:Gastroscopy / Q000009:adverse effects*; D005934:Glucagon / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D011292:Premedication; D011674:Pulse
D002086:Butylscopolammonium Bromide; D001285:Atropine; D005934:Glucagon; D003975:Diazepam
Kardiale Nebenwirkungen der Osophago-Gastro-Duodenoskopie in Abhängigkeit von der Prämedikation.