Effect of tissue specific mitotic inhibitors on survival time of spontaneous and virus-induced murine leukaemia and influence on myocardial degeneration.
Treatment of adult AKR mice with tissue-specific mitotic inhibitor mol. wt. 1,000--20,000 extracted from the AKR thymus significantly delayed the onset of spontaneous thymus leukaemia, whereas extracts of other organs were without effect. A slight prolongation of survival time was found with spleen extract when administered to BALB/c mice infected with Rauscher virus, which causes leukaemia starting in the spleen. Thymus extracts of MW 100,000--300,000 caused myocardial degeneration in some leukaemic and nonleukaemic mice.
D000818:Animals; D009202:Cardiomyopathies / Q000139:chemically induced*; D006400:Hematocrit; D007942:Leukemia, Experimental / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D007958:Leukocyte Count; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008938:Mitosis / Q000187:drug effects*; D008970:Molecular Weight; D009206:Myocardium / Q000473:pathology; D011379:Prognosis; D011925:Rauscher Virus; D013154:Spleen; D013949:Thymus Extracts / Q000627:therapeutic use* / Q000633:toxicity; D013997:Time Factors; D014020:Tissue Extracts / Q000627:therapeutic use*
D013949:Thymus Extracts; D014020:Tissue Extracts