Isolation of a virulent strain of Ehrlichia phagocytophila from the blood of cattle in the Isle of Man.
A blood sample from a cow in the Isle of Man caused a severe Ehrlichia phagocytophila infection when inoculated into a splenectomised calf. The parasite was passaged successively into a further splenectomised calf and then into two intact animals. One of the splenectomised calves and one of the intact animals died of the infection which was characterised by causing a sustained febrile response apparently correlated with a marked invasion of monocytes by the rickettsiae.
D000818:Animals; D001769:Blood / Q000382:microbiology*; D002417:Cattle; D002418:Cattle Diseases / Q000382:microbiology*; D004536:Ehrlichia / Q000302:isolation & purification*; D008297:Male; D009000:Monocytes / Q000382:microbiology; D009504:Neutrophils / Q000382:microbiology; D012287:Rickettsiaceae / Q000302:isolation & purification*; D012288:Rickettsiaceae Infections / Q000382:microbiology / Q000662:veterinary*; D006113:United Kingdom