[HLA and IgA deficiency].
The distribution of 29 HLA-A and B antigens was compared in 50 Caucasoïds with an IgA deficit and in 300 healthy controls. The patients were divided in 3 groups: 1) Partial selective IgA deficit (40); 2) Total selective Iga deficit (7); 3) IgA deficit associated with hypogammaglobulinemia (3). The patients viewed as a whole, we observed an increased frequency for the antigens HLA-Aw19, HLA-B5 and HLA-BW17. Yet, the modifications are not cleanly significant, with p less than 0.05, but p corrected not significant. We also considered the 3 groups separated and we did not remark any particular association with HLA. The data concerning HLA and congenital immune insufficiencies are reviewed. The most authors at once studied several immune defects. Only one Hungarian work was performed on IgA deficit. We do not confirm HLA-A1 and HLA-B8 increased frequencies, as it was reported, in Hungary, by Bajtai and al. There is no evident association between one HLA-A or B gene and the IgA deficit. The possible relation of IgA insufficiency with autoimmunity and allergy would justify complementary investigations, especially about HLA-D and Ia genes repartition in this disease.
D000293:Adolescent; D000328:Adult; D000361:Agammaglobulinemia / Q000276:immunology; D001249:Asthma / Q000276:immunology; D001991:Bronchitis / Q000276:immunology; D002648:Child; D005260:Female; D006680:HLA Antigens; D006650:Histocompatibility Testing; D006801:Humans; D017098:IgA Deficiency; D008297:Male
D006680:HLA Antigens
HLA et déficit en IgA.