Effects of cimetidine on stress ulcer and gastric acid secretion in the rat.
Cimetidine at 25, 50, and 100 mg/kg significantly inhibited gastric acid secretion in rats with chronic gastric cannulas. Rats receiving either 50 or 100 mg/kg of cimetidine secreted significantly less gastric acid 3 hr after injection. Cimetidine failed to reduce the number or size of gastric lesions in rats exposed to the activity-stress procedure, but cimetidine at 100 mg/kg significantly reduced the number and size of gastric lesions in rats subjected to a supine restraint procedure.
D000818:Animals; D002927:Cimetidine / Q000494:pharmacology*; D005750:Gastric Juice / Q000378:metabolism*; D006146:Guanidines / Q000494:pharmacology*; D008297:Male; D010919:Placebos; D051381:Rats; D013276:Stomach Ulcer / Q000209:etiology / Q000503:physiopathology*; D013312:Stress, Physiological / Q000150:complications; D013997:Time Factors
D006146:Guanidines; D010919:Placebos; D002927:Cimetidine