Effects of pimozide and bromocriptine on anterior pituitary cell proliferation.
The effects of pimozide (a dopamine receptor blocker) and bromocriptine (a dopamine receptor agonist) on the mitotic incidence in the anterior pituitary in male rats was investigated. It was shown that pimozide enhanced anterior pituitary mitotic activity in male rats. Bromocriptine, in turn, suppressed anterior pituitary cell proliferation in estradiol-treated male rats. A dopaminergic control of anterior pituitary mitotic activity is suggested.
D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology*; D004958:Estradiol / Q000494:pharmacology; D008297:Male; D008938:Mitosis / Q000187:drug effects; D010868:Pimozide / Q000494:pharmacology*; D010903:Pituitary Gland, Anterior / Q000187:drug effects*; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects*
D011954:Receptors, Dopamine; D010868:Pimozide; D001971:Bromocriptine; D004958:Estradiol