Contrast agents lower ventricular fibrillation threshold.
Ventricular fibrillation thresholds were measured in anesthetized, closed-chest dogs during the injection of Renografin 76 or Conray 400 into the left coronary artery. Both agents significantly lowered fibrillation threshold--Renografin to 58 +/- 7%; Conray to 20 +/- 5% of control, respectively. The experimental method estimates fibrillatory potential of contrast media more precisely than previous methods. The initial results parallel relative toxicities observed in clinical usage.
D000818:Animals; D002304:Cardiac Pacing, Artificial; D017023:Coronary Angiography; D003973:Diatrizoate / Q000031:analogs & derivatives*; D003974:Diatrizoate Meglumine / Q000633:toxicity*; D004285:Dogs; D004562:Electrocardiography; D007482:Iothalamate Meglumine / Q000633:toxicity*; D014693:Ventricular Fibrillation / Q000139:chemically induced*
D003973:Diatrizoate; D003974:Diatrizoate Meglumine; D007482:Iothalamate Meglumine