[Ratio of primidone to phenobarbital serum levels as a criterion in the assessment of anticonvulsive therapy with primidone (author's transl)].
Serum levels of primidone and phenobarbital were measured and showed a relatively constant ratio in patients under primidone monotherapy. In outpatients, however, this ratio was lower and the range of its values wider than in hospitalized children, and the difference was significant (1:2.05 or 1:2.95). The reason for this turned out to be irregular intake of the drug by the outpatients. The ratio of primidone to phenobarbital serum levels offers itself as a control of regularity of intake of primidone.
D000293:Adolescent; D000553:Ambulatory Care; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000188:drug therapy*; D006801:Humans; D010634:Phenobarbital / Q000097:blood*; D011324:Primidone / Q000097:blood* / Q000627:therapeutic use
D011324:Primidone; D010634:Phenobarbital
Bestimmung des Serumkonzentrationsverhältnisses von Primidon/Phenobarbital bei antikonvulsiver Primidonbehandlung als weiteres Kriterium bei der Therapiebeurteilung.