Responsiveness of the rabbit eye to adrenergic and cholinergic agonists after treatment with 6-hydroxydopamine or alpha-methyl-para-tyrosine: Part I--Pupillary changes.
The responses of rabbit pupils to graded doses of both adrenergic and cholinergic drugs after chemical sympathectomy with 6-hydroxydopamine have been examined. For comparison, similar data were obtained in rabbits treated chronically with the norepinephrine synthesis inhibitor, alpha-methyl-para-tyrosine. While quantitative differences were apparent, the effects of these 2 treatments were qualitatively similar. In both cases, a marked reduction in the responsiveness of the iris to cholinergic agonists accompanied the development of supersensitivity to adrenergic amines.
D000287:Administration, Topical; D000818:Animals; D002217:Carbachol / Q000008:administration & dosage; D004347:Drug Interactions; D004837:Epinephrine / Q000008:administration & dosage; D006892:Hydroxydopamines / Q000008:administration & dosage*; D007274:Injections, Intraperitoneal; D007498:Iris / Q000187:drug effects; D007545:Isoproterenol / Q000008:administration & dosage; D008297:Male; D008781:Methyltyrosines / Q000008:administration & dosage*; D009638:Norepinephrine / Q000008:administration & dosage; D010862:Pilocarpine / Q000008:administration & dosage; D011680:Pupil / Q000187:drug effects* / Q000294:innervation; D011817:Rabbits; D013564:Sympathetic Nervous System / Q000187:drug effects
D006892:Hydroxydopamines; D008781:Methyltyrosines; D010862:Pilocarpine; D002217:Carbachol; D007545:Isoproterenol; D009638:Norepinephrine; D004837:Epinephrine