Efffect of exo- and endo-2-aminobenzonorbornene on the acceleration of efflux of norepinephrine from isolated perfused rabbit atria.
The effect of exo- and endo-2-aminobenzonorbornene on the efflux of norepinephrine (NE) from isolated perfused rabbit atria was studied. These compounds can be considered conformationally rigid analogs of amphetamine and as such can be used to study the stereochemical requirements for amphetamine like activity. The exo isomer was found to produce an acceleration of efflux of previously accumulated 3H-NE from pargyline treated atria from rabbits which had been pretreated with either reserpine or dl-alpha-methyltryrosine (alpha-MT). The endo isomer however was found to accelerate efflux of 3H-NE from pargyline treated atria from reserpine pretreated rabbits but not from rabbits that had been pretreated with alpha-MT.
D000818:Animals; D006321:Heart / Q000187:drug effects*; D006325:Heart Atria / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009206:Myocardium / Q000378:metabolism; D009636:Norbornanes / Q000494:pharmacology*; D009638:Norepinephrine / Q000378:metabolism*; D011817:Rabbits; D013329:Structure-Activity Relationship
D009636:Norbornanes; C013805:2-aminobenzonorbornene; D009638:Norepinephrine