Attempts to attenuate the cardiostimulatory effects of ketamine.
In an attempt to attenuate the cardiostimulatory effects of ketamine, a number of drugs were given individually, or in combination, to fit adults undergoing body surface operations, either before or aftera ketamine induction of 1 mg kg-1 followed by an infusion of 1 mg ml-1. Of these, practolol, phentolamine, practolol-phentolamine, phentolamine-practolol, promethazine, hexamethonium, procainamide and verapamil were unacceptable. Labetalol, in doses of 0.5 mg kg-1 and 1.0 mg kg-1, proved to be the most promising drug and is worthy of further study.
D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology; D000959:Antihypertensive Agents / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007649:Ketamine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D011217:Practolol / Q000494:pharmacology; D011398:Promethazine / Q000494:pharmacology; D013268:Stimulation, Chemical; D013997:Time Factors
D000889:Anti-Arrhythmia Agents; D000959:Antihypertensive Agents; D007649:Ketamine; D011398:Promethazine; D011217:Practolol