Survival of human 51Cr erythrocytes in guinea-pigs.
A guinea-pig model for study of the survival of human erythrocytes has been developed. The T1/2 survival of human erythrocytes in guinea pigs treated with ethyl palmitate and cobra venom factor is about 3 days. This model is particularly suited to the study of the pathogenesis and therapy of certain intrinsic red cell disorders, such as sickle-cell disease.
D000017:ABO Blood-Group System; D000818:Animals; D002470:Cell Survival; D004546:Elapid Venoms / Q000494:pharmacology; D017707:Erythrocyte Transfusion; D004912:Erythrocytes; D006168:Guinea Pigs; D006801:Humans; D008954:Models, Biological; D010168:Palmitates / Q000494:pharmacology; D014183:Transplantation, Heterologous
D000017:ABO Blood-Group System; D004546:Elapid Venoms; D010168:Palmitates