The ageing gut: a study of intestinal absorption in relation to nutrition in the elderly.
This study was designed to assess the functional efficiency of the ageing small intestine and the possible role of malabsorption in old people with nutritional deficiencies. Fifty subjects aged 65 to 92 years were studied, of whom 33 presented with anaemia, chronic diarrhoea or bone pains, and 17 were apparently healthy 'controls' with no relevant symptoms. Tests of intestinal function included blood xylose and iron absorption curves, a double isotope Schilling test, faecal fat, urinary indican and small bowel radiology, with duodenal aspiration and jejunal biopsy in some cases. On the basis either of steatorrhoea or at least two other abnormal parameters of absorption, there were 15 cases of malabsorption. Thirteen of these had symptoms but two were 'controls'. Four of these had duodenal diverticulosis, two had the post-gastrectomy syndrome, and one had calcific pancreatitis. Malabsorption in the remaining eight cases was not fully explained. The age range of this last group was 72--86 years; one of them had a contaminated small bowel and two showed some evidence of pancreatic insufficiency. Malabsorption emerged as a significant cause of low levels of serum iron, haemoglobin and calcium. The blood xylose test is a useful screening procedure for intestinal malabsorption in old age, but full evaluation calls for investigation of pancreatic function.
D000368:Aged; D000375:Aging; D005243:Feces / Q000032:analysis; D006801:Humans; D007200:Indican / Q000652:urine; D007408:Intestinal Absorption; D007421:Intestine, Small / Q000378:metabolism*; D007501:Iron / Q000378:metabolism; D008055:Lipids / Q000032:analysis; D008286:Malabsorption Syndromes / Q000378:metabolism*; D010179:Pancreas / Q000503:physiopathology; D014805:Vitamin B 12 / Q000378:metabolism; D014994:Xylose / Q000378:metabolism
D008055:Lipids; D014994:Xylose; D007501:Iron; D007200:Indican; D014805:Vitamin B 12