[Dependence of the component makeup of the gentamicin complex on Micromonospora purpurea var. violacea 1935 cultivation conditions].
Dependence of biosynthesis of gentamicin and vitamin B12 on complex and "synthetic" media under conditions of decreased aeration, increased phosphorus levels and non-optimal content of carbon source was studied. The decreased levels of vitamin B12 production under conditions of the non-optimal content of the carbon source and increased phosphorus levels in the medium resulted in decreased production of the antibiotic complex as a whole and decreased relative content of the most methylated gentamicins C1 and C2 in the complex. Decreased aeration lowered the mycelium productivity with respect to the antibiotic production without changing the ratio of the components in the complex and the level of vitamin B12 production.
D000332:Aerobiosis; D050260:Carbohydrate Metabolism; D003470:Culture Media; D004305:Dose-Response Relationship, Drug; D005839:Gentamicins / Q000032:analysis / Q000096:biosynthesis*; D008847:Micromonospora / Q000378:metabolism*; D010758:Phosphorus / Q000378:metabolism
D003470:Culture Media; D005839:Gentamicins; D010758:Phosphorus
Zavisimost' komponentnogo sostava gentamitsinovogo kompleksa ot usloviĭ kul'tivirovaniia Micromonospora purpurea var. violacea 1935.