Absorption of 5-fluorouracil through gastric epithelium.
We examined the amount of 5-Fu absorbed through the gastric epithelium after oral administration in both dogs and patients with bladder tumors. The concentrations of 5-Fu in the serum, bladder wall, tumor mass and regional lymphnodes were sufficiently high to suppress the growth of tumor cells.
D000042:Absorption; D000284:Administration, Oral; D000818:Animals; D004285:Dogs; D005472:Fluorouracil / Q000008:administration & dosage / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D008198:Lymph Nodes / Q000378:metabolism; D001743:Urinary Bladder / Q000378:metabolism; D001749:Urinary Bladder Neoplasms / Q000378:metabolism
D005472:Fluorouracil