Controlled delivery of theophylline: chemistry of 7-acyl- and 7,7'-acylditheophylline derivates.
7-Acyl- and 7,7'-acylditheophylline derivatives were prepared from the reaction of theophylline with acid chlorides. In addition, a novel synthesis of these compounds was developed, which proceeds through an acylonium ion generated under mild conditions. The physical properties and stability of the derivative of choice, 7,7'-succinylditheophylline, depend on the synthetic procedure employed. This compound is a useful controlled-release prodrug of theophylline.
D000818:Animals; D001682:Biological Availability; D003692:Delayed-Action Preparations; D004285:Dogs; D004355:Drug Stability; D005260:Female; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008722:Methods; D013806:Theophylline / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism
D003692:Delayed-Action Preparations; D013806:Theophylline