Experimental and clinical trials of new 99mTc-labeled hepatobiliary agents.
Several new derivatives of lidocaine were synthesized and used to examine the intra- and extrahepatic bile ducts and gallbladder. Diisopropyl-IDA exhibited approximately twice the bile concentration of 131I-rose bengal during the first hour after injection. P-butyl-IDA also concentrates moderately well in the bile and has the added advantage of very low excretion into the urine (2%). It seems more effective than the other IDA derivatives at high bilirubin levels.
D001652:Bile Ducts / Q000000981:diagnostic imaging*; D005704:Gallbladder / Q000000981:diagnostic imaging*; D006801:Humans; D008012:Lidocaine / Q000031:analogs & derivatives* / Q000378:metabolism; D011877:Radionuclide Imaging; D012395:Rose Bengal; D013667:Technetium
D012395:Rose Bengal; D013667:Technetium; D008012:Lidocaine