[Effect of imipramine-like antidepressants on head shaking induced by 5-hydroxytryptophan in mice].
In the reaction of head twitching (HT) in mice in response to 5-oxytryptophan administration in the capacity of a serotonergic model antidepressants chlorimipramine and imipramine and also chlorpheniramine (suprastin) expressed a serotonopositive action in doses of 1.0, 5,0, and 1.0 mg/kg, respectively. Quiprazine produced a serotonomimetic action. Desipramine exerted abmivalent activity in doses of 1.0--20.0 mg/kg, whereas iprindol and morphaphen were ineffective in doses up to 20.0 mg/kg. Amitriptyline, noveril, melitracene, trimipramine, and ludiomil inhibited HT in doses of from 0.5, 1.0, 20.0, 20.0, and 20.0 mg/kg, respectively. The results are discussed in the light of the concept on the complex "neurotransmitter activity" spectrum of imipramine-like antidepressants.
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001921:Brain / Q000378:metabolism*; D007099:Imipramine / Q000494:pharmacology / Q000627:therapeutic use; D051379:Mice; D009069:Movement Disorders / Q000139:chemically induced / Q000188:drug therapy; D012701:Serotonin / Q000378:metabolism*
D000928:Antidepressive Agents; D012701:Serotonin; D007099:Imipramine
Vliianie imipraminopodobnykh antidepressantov na vstriakhivaniia golovoĭ u mysheĭ, vyzyvaemye 5-oksitriptofanom.