Dramatic pyrexic and cardiovascular response to intravaginal prostaglandin E2.
The efficacy of prostaglandin E2 (PGE2) for the induction of labor in pregnancies complicated by IUFD or missed abortion has been demonstrated. Gastrointestinal and pyrexic side effects are frequently observed. The following report describes two patients with documented IUFD who experienced a dramatic pyrexic and cardiovascular response to the intravaginal PGE2. In addition, evidence will be provided to account for this unusual pharmacologic reaction, as well as provide a method of managing this unusual side effect.
D000030:Abortion, Missed; D000328:Adult; D002318:Cardiovascular Diseases / Q000139:chemically induced*; D005260:Female; D005313:Fetal Death; D005334:Fever / Q000139:chemically induced*; D006801:Humans; D007022:Hypotension / Q000139:chemically induced; D007751:Labor, Induced / Q000009:adverse effects*; D011247:Pregnancy; D011458:Prostaglandins E / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D012120:Respiration Disorders / Q000139:chemically induced; D013488:Suppositories; D013610:Tachycardia / Q000139:chemically induced; D014621:Vagina
D011458:Prostaglandins E; D013488:Suppositories