title: Demonstration of early capillary lesions in the brain by means of artificial reperfusion.
abstract: Nine patients are reported in whom functional brain death was determined as exactly as possible by neurological (in part also electroencephalographic and/or angiographic) examination in combination with analysis of the clinical history. During the first hour, at 2-4 hr, and later than 4 hr after the occurrence of functional brain death, the mean systemic pressure was raised to 30% above normal by infusion of Arterenol. The infusions lasted 15-30 min; in spite of the raised blood pressure, the patients died of cardiovascular attention to vascular damage; none was found whenever the reperfusion was completed within the first hour after determination of circulatory arrest. In all three cases in which reperfusion was performed, after more than 4 hr the neuropathological findings were similar. In one case the EEG showed a burst-type pattern during reperfusion within the first hour after determination of brain death.
mesh_terms: D001794:Blood Pressure; D001921:Brain / Q000473:pathology*; D001926:Brain Death; D002533:Cerebral Angiography; D002543:Cerebral Hemorrhage / Q000473:pathology; D004569:Electroencephalography; D006801:Humans; D009336:Necrosis; D009638:Norepinephrine / Q000627:therapeutic use; D012151:Resuscitation
chemical_list: D009638:Norepinephrine