Toxicity studies with human leukocyte interferon in newborn rabbits.
Daily subcutaneous injections of 5 to 10 million units of partially purified human leukocyte interferon were given to newborn rabbits for 2 weeks or 1 month. The control groups received mock interferon, saline or nothing. The interferon treatment had no overt effect on the development of the animals during the period of treatment. The rabbits treated with interferon had leukocytosis, splenomegaly and prolonged postnatal extramedullary hematopoiesis in the liver and spleen. Certain immune responses were also demonstrated in the rabbits treated with interferon and mock interferon preparations. Platelet counts and the serum-ASAT, -ALAT, -LD and alkaline phosphatase values were normal.
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000831:Animals, Newborn; D000906:Antibodies / Q000032:analysis; D001219:Aspartate Aminotransferases / Q000097:blood; D001772:Blood Cell Count; D001835:Body Weight / Q000187:drug effects; D006410:Hematopoiesis / Q000187:drug effects; D006801:Humans; D007372:Interferons / Q000008:administration & dosage / Q000633:toxicity*; D007962:Leukocytes; D008099:Liver / Q000187:drug effects / Q000473:pathology; D011817:Rabbits; D013163:Splenomegaly / Q000209:etiology
D000906:Antibodies; D007372:Interferons; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase