title: [Anti-arrhythmic properties of ethmosine (clinico-experimental study)].
abstract: The antiarrhythmic activity of some acyl derivatives of phenothiazine was studied. Ethmozine proved to be the most effective among them. It produced a marked antiarrhythmic effect both in experiments and in the clinic. The effect of ethmozine is similar to that of quinidine, but it has a wider therapeutic range and is less toxic. The drug has practically no effect or arterial pressure, myocardial conduction and myocardial contraction. These properties of ethmozine as well as its ability to prolong the refractory period and reduce myocardial excitability allow it to be recommened for the management of tachyarrhythmic a-rhythmia.
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy*; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D003326:Coronary Circulation / Q000187:drug effects; D004285:Dogs; D004341:Drug Evaluation; D006329:Heart Conduction System / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D009025:Morpholines / Q000494:pharmacology / Q000627:therapeutic use; D010640:Phenothiazines / Q000494:pharmacology / Q000627:therapeutic use*; D011342:Procainamide / Q000627:therapeutic use; D011802:Quinidine / Q000627:therapeutic use; D051381:Rats
chemical_list: D000889:Anti-Arrhythmia Agents; D009025:Morpholines; D010640:Phenothiazines; D011802:Quinidine; D011342:Procainamide
vernacular_title: Antiaritmicheskie svoĭstva etmozina (kliniko-eksperimental'noe issledovanie).