title: [The influence of non-metabolizable alpha- and beta-glycosides on the regulation of sorbose fermentation of salmonellae (author's transl)].
abstract: Fermentation of sorbose by late positive Salmonella wildtype cultures and by mutant strains splitting this sugar promptly is restrained by the beta-glucoside salicine and likewise by 1-o-methyl-alpha-D-glucopyranoside (MGP), but is not influenced by lactose or sucrose. In growing cultures salicine works more powerful on sorbose utilization than MGP while in dense suspensions of non-multiplying bacteria the relations are reversed. Among the majority of wildtype strains this suppressive effect is diminished or abolished by dimethylsulfoxide (DMSO), but there are strains in which the glucoside effect is enhanced by DMSO. The sorbose fermentation lag in the presence of salicine or MGP is detectable, too, in dense suspensions of promptly splitting Salmonella mutant strains in media poorly supplied with nitrogen and must therefore be attributed to a non-mutative event. From prior work (Stenzel, 1977c) we got some evidence that this event might depend on an inhibition of enzyme induction. Targets and mode of action of the alpha- and beta-glucoside largely seem to be identical, though possibly there might exist minor differences.
mesh_terms: D001592:Benzyl Alcohols / Q000494:pharmacology; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D005285:Fermentation / Q000187:drug effects; D005960:Glucosides / Q000494:pharmacology; D006027:Glycosides / Q000494:pharmacology*; D008757:Methylglucosides / Q000494:pharmacology; D009154:Mutation; D012475:Salmonella / Q000378:metabolism*; D013013:Sorbose / Q000378:metabolism*; D013045:Species Specificity
chemical_list: D001592:Benzyl Alcohols; D005960:Glucosides; D006027:Glycosides; D008757:Methylglucosides; D013013:Sorbose; D004121:Dimethyl Sulfoxide
vernacular_title: Die Wirkung nichtmetabolisierbarer alpha- und beta-Glycoside auf die Regulation der Sorbose-Verwertung von Salmonellen.