Humoral immunity conferred by the HDCS rabies vaccine Mérieux administered after exposure: 151 cases with and without specific immune globulin of human origin. Preliminary communication.
The results of the analysis of the neutralizing antibodies measured at days 30 and 90 after vaccination are described in brief. Different lots of Mérieux vaccine were used, of which two were checked separately for relative antigenic value by the Federal Public Health Service (CH). The lowest antigenic value (lot 0420 M) was 1.6 in relation to the standard NIH vaccine No.182. The inhibiting effect of immune globulin was shown to be significant with this lot, but not with the other, more powerful lots. The attention is drawn to isolated cases which did not present antibodies--or not a sufficient count--on days 30 or 90 according to the RFFI test.
D000328:Adult; D000367:Age Factors; D000917:Antibody Formation; D002648:Child; D046508:Culture Techniques; D006801:Humans; D007112:Immunity, Maternally-Acquired; D007136:Immunoglobulins / Q000008:administration & dosage / Q000627:therapeutic use*; D011818:Rabies / Q000628:therapy*; D011819:Rabies Vaccines / Q000008:administration & dosage / Q000276:immunology / Q000627:therapeutic use*
D007136:Immunoglobulins; D011819:Rabies Vaccines