title: Sialic acids of human large bowel mucosa: o-acylated variants in normal and malignant states.
abstract: Five sialic acid variants have been demonstrated in normal, 'transitional', and tumour extracts of human large bowel mucosa by thin-layer chromatography. Two-dimensional thin-layer chromatography, with intermediate alkaline hydrolysis, confirmed that the variants were N-acetyl neuraminic acids with additional O-acylation. Cases studied so far show changes in the proportions of these variants in malignancy.
mesh_terms: D000215:Acylation; D000818:Animals; D002417:Cattle; D002855:Chromatography, Thin Layer; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism*; D007414:Intestinal Neoplasms / Q000378:metabolism*; D007420:Intestine, Large / Q000378:metabolism*; D012794:Sialic Acids / Q000378:metabolism*
chemical_list: D012794:Sialic Acids