Alcohol consumption in rats treated with lithium carbonate or rubidium chloride.
Wistar-NTRU rats, offered a free choice between tap water and a 10% ethanol solution (v/v) in the absence of reinforcement, were injected for five days with Li2 CO3, RbCl or placebo. Lithium-treated group consumed 25% more liquid per day but chose to take 14.5% less alcohol than controls (p less than 0.05). By contrast, rubidium-treated animals consumed 15% less liquid but 70% more alcohol than control animals (p less than 0.005). Rubidium-treated rats were strikingly more active than the other two groups: their motility index was 60.0 as compared to 33.6 for lithium-treated and 29.4 for control rats. Serum glucose and urea nitrogen concentration were not significantly affected by the treatment but serum alcohol content was low in lithium-treated and high in rubidum-treated animals.
D000428:Alcohol Drinking / Q000187:drug effects*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001806:Blood Urea Nitrogen; D004327:Drinking Behavior / Q000187:drug effects; D000431:Ethanol / Q000097:blood; D008094:Lithium / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D012413:Rubidium / Q000494:pharmacology*; D013997:Time Factors
D001786:Blood Glucose; D000431:Ethanol; D008094:Lithium; D012413:Rubidium