Synthesis and hypotensive activity of N-alkyl-N"-cyano-N'-pyridylguanidines.
A variety of N-alkyl-N'-pyridyl-N"-cyanoguanidines III was prepared as potential bioisosteres of hypotensive N-alkyl-N'-pyridylthioureas Ia. Optimal activity of the N,N'-disubstituted cyanoguanidines III was assoicated with the presence of four to seven carbon branched alkyl and 3- or 4-pyridyl groups. Maximum potency was displayed by N-tert-pentyl-N'-3 pyridyl-N"-cyanoguanidine (20). This compound proved to be 200 times more potent than the corresponding thiourea in hypertensive rats and dogs. In comparison with guancydine, which is the de-3-pyridyl analogue of 20, a 150-fold increase of potency in spontaneously hypertensive rats was obtained with 20 and its tert-butyl analogue 19. The observed activity appears to be due to direct vascular relaxation. On a weight basis compounds 19, 20, 50, and 101 compared favorably with hydralazine.
D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D004285:Dogs; D005260:Female; D006146:Guanidines / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D006973:Hypertension / Q000188:drug therapy; D007928:Lethal Dose 50; D051379:Mice; D051381:Rats; D013329:Structure-Activity Relationship
D000959:Antihypertensive Agents; D006146:Guanidines