title: [Test of O,O-dimethyl(1-hydroxy-2,2,2-trichloroethyl)phosphonate (Trichlorfon) for carcinogenic acitivity in rats by oral (oesphageal-gastric intubation) and intraperitoneal application (author's transl)].
abstract: O,O-Dimethyl (1-hydroxy-2,2,2-trichloroethyl)phosphonate (Trichlorfon) is produced at a large scale and used in many countries e. g. in agriculture and housholds to control insects and on animals to control parasties. The compound (dissolved in isotonic sodium chloride solution) was tested for carcinogenic activity in albino rats by oral (oesophageal-gastric intubation) and intraperitoneal administration. The period of treatment was 90 weeks. The experiment was terminated at 118 weeks. There was no statistically significant difference when the tumor incidence in the groups of treated and control animals was compared. No carcinogenic activity of the compound could be demonstrated in rats at either route of application.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002273:Carcinogens; D005260:Female; D007274:Injections, Intraperitoneal; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D051381:Rats; D014236:Trichlorfon / Q000633:toxicity*
chemical_list: D002273:Carcinogens; D014236:Trichlorfon
vernacular_title: Zur Prüfung von O,O-Dimethyl(1-hydroxy-2,2,2-trichloräthyl)-phosphonat (Trichlorphon) auf kanzerogene Wirkung in Ratten durch orale (ösophago-gastrikale Sondung) und intraperitoneale Applikation.