[Enzyme activity during regeneration under acute and chronic liver lesion with CCL4].
Activity of alanine and aspartate aminotransferase, alkaline phosphatase, adenosine, desaminase and AMP-aminohydrolase was determined in rats in the process of the liver regeneration under acute and chronic lesion with CCl4. It is shown that under chronic lesion of the liver with CCl4, in contrast to the acute one, changes in the aminotransferase activity in blood serum are not expressed in the liver, the activity is essentially decreased. A steady increase was observed in the activity of adenosine desaminase, AMP-aminohydrolase and alkaline phosphatase in the liver and blood serum. It is concluded that the normal regenerative process is accompanied by short-term shifts of the enzymes activity in the liver and blood serum. The development of a chronic process results in a characteristic increase in the activity of adenosine desaminase, AMP-aminohydrolase and alkaline phosphatase in the liver and blood serum.
D000659:AMP Deaminase / Q000378:metabolism; D000208:Acute Disease; D000243:Adenosine Deaminase / Q000378:metabolism; D000410:Alanine Transaminase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D002252:Carbon Tetrachloride Poisoning / Q000201:enzymology*; D002908:Chronic Disease; D008099:Liver / Q000201:enzymology*; D008115:Liver Regeneration; D051381:Rats
D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D000243:Adenosine Deaminase; D000659:AMP Deaminase
Izuchenie aktivnosti fermentov v pecheni v protsesse regeneratsii pri ostrom i zhronicheskom porazhenii SSL4.