[Physiochemical properties of LIA-0191 A and B antibiotics].
An antifungal antibiotic LIA-0191 was isolated from the mycelium by methanol extraction. It was shown with thin-layer chromatography that it consisted of components A and B. Component A was isolated with collumn chromatography on silica gel, recrystalization from the solvent mixture as a monocomponent crystalline substance. On the basis of the physicochemical and biological properties it was identified with sentacidin. Component B was obtained from preparation LIA-0191 by the method of counter-current distribution and recrystalization from methanol. Comparison of its physico-chemical and biological properties with those of the known purines and pyrimidine pyrrol showed that antibiotic LIA-0191 B is new.
D000935:Antifungal Agents / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D011684:Purine Nucleosides; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D000935:Antifungal Agents; D011684:Purine Nucleosides
Fiziko-khimicheskie svoĭstva antibiotikov LIA-0191 A i B.