Absorption of sodium benzylpenicillin from the equine uterus after local Lugol's lodine treatment, compared with absorption after intramuscular injection.
Plasma concentrations of sodium benzylpenicillin following intrauterine infusion were increased by reducing the volume of solution and expelling air from the vagina after infusion. Instillation of 10 per cent Lugol's iodine solution into the uterus before penicillin infusion further increased the absorption rate, although peak plasma levels of penicillin were less than half those which resulted from intramuscular injection of the same dose.
D000042:Absorption; D000818:Animals; D005260:Female; D006736:Horses / Q000097:blood*; D007267:Injections; D007273:Injections, Intramuscular; D007455:Iodine / Q000494:pharmacology*; D010400:Penicillin G / Q000008:administration & dosage / Q000097:blood*; D014599:Uterus / Q000187:drug effects / Q000378:metabolism*
D007455:Iodine; D010400:Penicillin G