title: The effect of sleep upon human circadian rhythms.
abstract: Subjects who slept for 4 h from 0000, and for a second 4 h variously distributed over the day, have provided values for rectal temperature and for urinary excretion of water, potassium, sodium, chloride, phosphate, creatinine, calcium and urate in the sleeping subject at all hours of the 24. These are compared with similar values in the wakeful subject. Temperature was lower during sleep at all hours except 1000 and 1200, and the difference was maximal shortly before 0000. At all hours potassium excretion was lower and phosphate excretion higher during sleep. Cosinor analysis of the different variables in the sleeping subject is compared with that in subjects following nycthemeral habits, and the interaction between endogenous rhythms and external influences such as sleep is discussed. The phasing of the temperature and urinary rhythms was essentially normal by the end of the observations. By contrast in a subject who slept at irregular hours mimicking the habits of an air pilot a free-running rhythm unrelated to the habits of sleep emerged. When he was finally living again on normal time his temperature and urinary acrophases had moved to the middle of the night. Phosphate excretion was largely exogenous, falling consistently when subjects rose after 8 h, but not after 4 h of sleep.
mesh_terms: D000293:Adolescent; D000328:Adult; D001831:Body Temperature; D002118:Calcium / Q000652:urine; D002712:Chlorides / Q000652:urine; D002940:Circadian Rhythm; D003404:Creatinine / Q000652:urine; D004231:Diuresis; D005260:Female; D006801:Humans; D008297:Male; D010710:Phosphates / Q000652:urine; D011188:Potassium / Q000652:urine; D012890:Sleep / Q000502:physiology*; D014195:Travel; D014527:Uric Acid / Q000652:urine; D014554:Urination
chemical_list: D002712:Chlorides; D010710:Phosphates; D014527:Uric Acid; D003404:Creatinine; D011188:Potassium; D002118:Calcium