Cerebrovascular permeability in acute arterial hypertension. Effect of unilateral ligation of the common carotid artery.
Ligation of the right common carotid artery prevented protein extravasation in the homolateral cerebral hemisphere when a blood pressure increase was induced by bicuculline or amphetamine. In addition to a blood pressure increase these two drugs induce a vasodilatation, which makes the resistance vessels particularly vulnerable to the mechanical stress of high intravascular pressure. The ratio between the mean arterial blood pressure in the femoral artery and the carotid artery distal to the ligation was approximately 0.5; slightly higher after than prior to the pressure increase.
D000208:Acute Disease; D000661:Amphetamine; D000818:Animals; D001640:Bicuculline; D001812:Blood-Brain Barrier; D001921:Brain / Q000098:blood supply*; D002199:Capillary Permeability; D002343:Carotid Artery, Internal / Q000601:surgery*; D006973:Hypertension / Q000139:chemically induced / Q000503:physiopathology*; D008026:Ligation; D008297:Male; D051381:Rats; D012711:Serum Albumin, Radio-Iodinated
D012711:Serum Albumin, Radio-Iodinated; D000661:Amphetamine; D001640:Bicuculline