[Formation of DNA--protein crosslinks and their possible elimination in cultures of normal human fibroblasts after exposure to embichin].
New methods of radiometry and fractionation of cell lysates on hydroxyapatite were applied to determine the crosslinkage between DNA and protein induced by embiquin in cell culture of normal human skin fibroblasts. Such crosslinks were found to be formed; they were eliminated in long-term cultivation of the cells after mutagen treatment.
D002478:Cells, Cultured; D055598:Chemical Phenomena; D002621:Chemistry; D004247:DNA / Q000378:metabolism*; D005347:Fibroblasts; D006801:Humans; D008466:Mechlorethamine / Q000494:pharmacology*; D011506:Proteins / Q000378:metabolism*; D012867:Skin
D011506:Proteins; D008466:Mechlorethamine; D004247:DNA
Obrazovanie sshivok DNK-belok i ikh vozmozhnaia éliminatsiia v kul'ture normal'nykh fibroblastov cheloveka posle deĭstviia émbikhina.