Epithelial alterations in fetal tracheal explants of Syrian golden hamsters exposed to diethylnitrosamine in utero.
The fetal tracheae (13th--15th day of gestation) of Syrian golden hamsters exposed in utero to diethylnitrosamine (DEN: 200--400mg/kg body wt.) were divided into cranial and caudal halves. Both sections were then organ-cultured for 4--6 weeks. The cranial explants developed 1.5 times as many epithelial tracheal lining alterations as the caudal explants. These changes were found 25--42 days after the beginning of explant culture and histologically demonstrated hyperplasia, metaplasia and dysplasia. No alterations occurred in the control explants.
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D006224:Cricetinae; D004052:Diethylnitrosamine / Q000633:toxicity*; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D005260:Female; D005333:Fetus / Q000187:drug effects; D005865:Gestational Age; D006965:Hyperplasia / Q000473:pathology; D008431:Maternal-Fetal Exchange; D008647:Mesocricetus; D008679:Metaplasia / Q000473:pathology; D009602:Nitrosamines / Q000633:toxicity*; D009924:Organ Culture Techniques; D011247:Pregnancy; D014132:Trachea / Q000187:drug effects* / Q000473:pathology
D009602:Nitrosamines; D004052:Diethylnitrosamine