MAO activity in rat brain stem and cerebral cortex: effect of acute and chronic treatment with ethanol and tetrahydropapaveroline.
Brain mitochondria were prepared from rat brain stem and cerebral cortex. Four substrates were used for enzyme characterization: dopamine, serotonin, noradrenaline and tryptamine. Monoamine oxidase (MAO) activities were tested on two different groups of rats treated with ethanol and tetrahydropapaveroline (THP); another group was used as control group. Data obtained show that there is almost always activation of MAO activities after acute treatment with either ethanol or THP, while after chronic treatment, the two drugs show opposite effects. In particular, the same type of MAO activity continues to be activated by ethanol, whereas it is inhibited by THP.
D000818:Animals; D001933:Brain Stem / Q000201:enzymology*; D002540:Cerebral Cortex / Q000201:enzymology*; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008928:Mitochondria / Q000201:enzymology; D008995:Monoamine Oxidase / Q000378:metabolism*; D010208:Papaverine / Q000031:analogs & derivatives*; D051381:Rats; D013765:Tetrahydropapaveroline / Q000008:administration & dosage / Q000494:pharmacology*
D000431:Ethanol; D013765:Tetrahydropapaveroline; D010208:Papaverine; D008995:Monoamine Oxidase