[New approach to the deposition of biologically active compounds in the body: an experimental study of the intracoronary administration of modified Sephadex].
The possibility of depositing in the myocardium drugs immobilized on modified Sephadex was studied. The method makes it possible to produce optimum local concentration of the drug with a predetermined rate of its detachment and has significant advantages over the commonly used methods for introducing drugs. Appraisal of a complex of data, including the findings of morphologic examination and analysis of the ECG and the curves of changes in the activity of CPK and hypoxanthine, has shown that intracoronary administration of 0.02 mg of Sephadex microspheres (approximately 20 000 microparticles) 20--40 mc in diameter per 1 g of dog myocardium has no harmful microembolic effect.
D000818:Animals; D003331:Coronary Vessels; D003402:Creatine Kinase / Q000097:blood; D003692:Delayed-Action Preparations; D003911:Dextrans / Q000008:administration & dosage*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004562:Electrocardiography; D004789:Enzyme Activation / Q000187:drug effects; D007042:Hypoxanthines / Q000097:blood; D008863:Microspheres; D010316:Particle Size; D013997:Time Factors
D003692:Delayed-Action Preparations; D003911:Dextrans; D007042:Hypoxanthines; D003402:Creatine Kinase
Novyĭ podkhod k deponirovaniiu biologicheski aktivnykh soedineniĭ v organizme: izuchenie intrakoronarnogo vvedeniia modifitsirovannogo sefadeksa v éksperiemnte.