[Circulatory responses to adrenaline administration at rest, during physical loading and under anesthesia].
In chronic experiments, the effects of 0.5 and 2.5 mcg/kg/min adrenaline infusion on central hemodynamics of conscions and anesthetized dogs were studied. Circulatory reactions elicited by blood volume change and running on treadmill were compared before and during adrenaline infusion. In conscions dogs, infusion of 0.5 mcg/kg/min adrenaline increased cardiac output and central venous pressure, decreased systemic vascular resistance and pumping heart capacity, while mean arterial pressure and heart rate were unchanged. It did not change pumping heart capacity in anesthetized dogs. Infusion of 0.5 mcg/kg/min adrenaline did not change the tendency of hemodynamic reactions on hemorrhage and blood transfusion. Exercise during adrenaline infusion resulted in a more cardiac output increase and lesser heart rate increase than without adrenaline. Infusion of 2.5 mcg/kg/min adrenaline induced more significant increase of arterial pressure in conscions dogs than in anesthetized.
D000768:Anesthesia, General; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001810:Blood Volume; D002302:Cardiac Output / Q000187:drug effects; D002496:Central Venous Pressure / Q000187:drug effects; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000494:pharmacology*; D004986:Ether; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D009020:Morphine; D005082:Physical Exertion; D014655:Vascular Resistance / Q000187:drug effects
D004986:Ether; D009020:Morphine; D004837:Epinephrine
Reaktsii krovoobrashcheniia na vvedenie adrenalina v usloviiakh pokoia, fizicheskoĭ nagruzki i narkoza.