title: Radiation response modified by degradable starch microspheres. Experiments on the rat's foot.
abstract: Skin reaction in the rat's foot was used as an experimental method to evaluate the protective potential of profound temporary hypoxia against roentgen radiation produced by a linear accelerator. Hypoxia was induced by intraarterial injection of degradable starch microspheres. The irradiation dose needed to evoke a certain reaction in the hypoxic feet was 2.0 times the dose giving the same reaction in a control group. The results point towards a new technique of inducing local hypoxia in healthy tissues which need to be protected in an irradiation field.
mesh_terms: D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005528:Foot / Q000098:blood supply; D006197:Hair / Q000528:radiation effects; D000860:Hypoxia / Q000209:etiology; D008297:Male; D008863:Microspheres; D011829:Radiation Dosage; D011832:Radiation Injuries; D011835:Radiation Protection / Q000379:methods*; D011855:Radiodermatitis / Q000517:prevention & control*; D051381:Rats; D012867:Skin / Q000098:blood supply / Q000528:radiation effects*; D013213:Starch
chemical_list: D013213:Starch