[Quantities of plasma polyps in the blood of male and female guinea pigs after application of monoiodinoacetate, acetylosalicyclic acid, nitrogen-containing excretory substances, and histamine (author's transl)].
Released cell protrusions designated as plasma polyps (PP) were quantificated from human blood of normal, male and non pregnant female, individuals by means of "inverted centrifugation" [4], and from blood of male and female, non pregnant and late pregnant, guinea pigs also. As control blood was taken from guinea pigs during nembutal narcosis or after narcotizing them by blows on the neck. In further series we examined the formation of PP after intravenous application of monoiodinoacetate (MIA) and acetylosalicyclic acid (ASS) with and without additional Na-pyruvate as an intermediary product of glucose metabolism. The influence of histamine and nitrogen-containing excretory substances was examined after intraperitoneal injections. The blood of normal individuals sporadically contained PP. The control animals (male and non pregnant female guinea pigs) showed about 1 X 10(6)PP per ml blood, late pregnant about 2 X 10(6). Doses of 12.5 mg MIA increased the number of PP from 2 X 10(6) up to 4 X 10(6), whereas additional Na-pyruvat doses kept the PP level at 1 X 10(6) the one of control animals. 21.4mg ASS administered to late pregnant guinea pigs increased the PP number up to 4 X 10(6)/ml blood. This effect was prevented by Na-pyruvat substitution. Intraperitoneal injection of excretory substances caused a moderate increase of PP to 1.8 X 10(6)/ml blood in average.
D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D001769:Blood / Q000187:drug effects*; D005260:Female; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D007461:Iodoacetates / Q000494:pharmacology*; D008297:Male; D009584:Nitrogen / Q000494:pharmacology; D013923:Thromboembolism / Q000139:chemically induced
D007461:Iodoacetates; D006632:Histamine; D009584:Nitrogen; D001241:Aspirin
Plasmapolypenzahlen im Blut männlicher und weiblicher Meerschweinchen nach Applikation von Monojodacetat, Acetylsalicylsäure, Reststickstoffkomponenten und Histamin.