title: Low prostaglandin concentrations cause cardiac rhythm disturbances. Effect reversed by low levels of copper or chloroquine.
abstract: In perfused male rat hearts concentrations of prostaglandins (PGs) E2 and F2alpha in the range 1 pg/ml to 10 ng/ml (2.8 X 10(-12) to 2.8 X 10(-8)M) consistently caused rhythm irregularities. Higher concentrations had no effect themselves and stabilized rhythm in hearts made unstable by lower concentrations. Copper ions (as the sulphate) at 2 X 10(-6)M stabilized hearts made unstable by PGs and when present prior to the PGs prevented PG induced disturbances. Chloroquine also reversed PG-induced rhythm changes.
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced* / Q000188:drug therapy; D002738:Chloroquine / Q000627:therapeutic use*; D003300:Copper / Q000627:therapeutic use*; D004357:Drug Synergism; D006329:Heart Conduction System / Q000187:drug effects*; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D011459:Prostaglandins E, Synthetic / Q000008:administration & dosage; D011461:Prostaglandins F, Synthetic / Q000008:administration & dosage; D051381:Rats
chemical_list: D011459:Prostaglandins E, Synthetic; D011461:Prostaglandins F, Synthetic; D003300:Copper; D002738:Chloroquine; D007213:Indomethacin