Restoration by adrenalectomy of weight and binding capacity of glucorcorticoid receptors of the thymus in AH 130 tumor-bearing rats.
The binding capacity of specific receptors for dexamethasone (11beta,17alpha,21-trihydroxy-9alpha-fluoro-16alpha-methyl-1,4-pregnadiene-3,20-dione) in the cytoplasm of the thymus of rats bearing AH 130 (solid-type) tumors decreased significantly during tumor growth. Adrenalectomy restored the binding capacity of the glucocorticoid receptors and the weight of the thymus to nearly the normal values in rats bearing tumors. The affinity of these receptors for dexamethasone was very low in rats bearing tumors, but it was also restored to nearly the normal value by adrenalectomy.
D000311:Adrenal Glands / Q000502:physiology*; D000315:Adrenalectomy; D000818:Animals; D003907:Dexamethasone / Q000378:metabolism; D008297:Male; D009374:Neoplasms, Experimental / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D009929:Organ Size; D051381:Rats; D011965:Receptors, Glucocorticoid / Q000378:metabolism*; D011987:Receptors, Steroid / Q000378:metabolism*; D013950:Thymus Gland / Q000378:metabolism* / Q000473:pathology
D011965:Receptors, Glucocorticoid; D011987:Receptors, Steroid; D003907:Dexamethasone