title: A "carrier effect" observed in assay of antidiarrhoeal drug compounds.
abstract: A carrier effect has been shown to exist in a stable isotope dilution assay for diphenoxylate. When a tetradeuterated analogue is used as a carrier and internal standard a sevenfold increase in sensitivity is observed for the unlabelled compound. Examination of a related pharmacologically active compound (SC-27166) showed a much smaller effect.
mesh_terms: D000930:Antidiarrheals / Q000032:analysis*; D002849:Chromatography, Gas / Q000379:methods*; D003903:Deuterium; D004157:Diphenoxylate / Q000032:analysis
chemical_list: D000930:Antidiarrheals; D004157:Diphenoxylate; D003903:Deuterium