Sterilization of a non-scrotal mammal (Suncus murinus L.) by intratesticular injection of cadmium chloride.
The testis of the musk shrew is resistant to subcutaneous administration of cadmium chloride. In contrast, a single intratesticular injection of cadmium chloride (0.01 to 0.03 mM/kg body weight) caused total destruction of germinal epithelium; Leydig cells, however, regenerated after an initial phase of atrophy. Unilateal injection of the drug induced degenerative changes in the injected testis only; the contralateral testis appeared normal macroscopically and histologically. The factors responsible for the differential response of the testes of this non-scrotal mammal to the two routes of administration of cadmium chloride are discussed.
D000818:Animals; D002104:Cadmium / Q000009:adverse effects*; D008297:Male; D009336:Necrosis; D012671:Seminiferous Tubules / Q000473:pathology; D012788:Shrews; D013245:Sterilization, Reproductive; D013737:Testis / Q000187:drug effects* / Q000473:pathology
D002104:Cadmium