Effect of ethanol on cardiac function in rats genetically selected for their ethanol preference.
The heart rate of male ANA (Alko, Non-alcohol) and AA (Alko, Alcohol) rats was significantly increased after peroral administration of 2.7 g ethanol/kg, but the tachycardia was of shorter duration in ANA rats, which avoid the drinking of ethanol solution. The PR intervals in the electrocardiograms of ANA rats became significantly longer than those of AA rats when 13.5 g ethanol/kg was given. The QT intervals were likewise longer in the electrocardiograms of ANA rats, but before as well as after the administration of ethanol. The results suggest that intracardiac conduction is more depressed by acute ethanol in the ANA than the AA strain of rats.
D000428:Alcohol Drinking; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004562:Electrocardiography; D000431:Ethanol / Q000097:blood / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects*; D008297:Male; D051381:Rats; D013997:Time Factors
D001786:Blood Glucose; D000431:Ethanol