title: Chromosome aberrations in the mother and the newborn from drug-addiction pregnancies.
abstract: Cytogenetic data were obtained prenatally and at delivery from 99 addicted pregnant women (80 from a methadone maintenance program and 19 heroin addicts) and their 101 offspring at delivery. About 10% of the 27,907 cells scored showed chromosomal aberrations. Chromosome damage was random and affected all chromosomes. There were no standard abnormal karyotypes. Apgar scores appeared to have some type of association with chromosome damage. In this study there were about 14 aberrations for every 10 aberrant cells scored.
mesh_terms: D001773:Blood Cells / Q000648:ultrastructure; D002842:Chromatids / Q000648:ultrastructure; D002869:Chromosome Aberrations; D005260:Female; D006556:Heroin Dependence / Q000235:genetics*; D006801:Humans; D007231:Infant, Newborn; D007621:Karyotyping; D008691:Methadone; D011247:Pregnancy; D011248:Pregnancy Complications; D019966:Substance-Related Disorders / Q000235:genetics*
chemical_list: D008691:Methadone