title: Plasma testosterone in molar pregnancy: Correlation with gestational age, uterine size, theca-lutein cyst and serum HCG.
abstract: Plasma testosterone and serum HCG were measured by radioimmunoassay in 46 patients with intact molar pregnancy. There was no significant difference in plasma testosterone between patients with theca-lutein cyst and those without the cyst. This suggests that ovarian contribution to the elevated testosterone in molar pregnancy is probably a minor one. No correlation was found between plasma testosterone and uterine size. However, a positive correlation (r=+0.3567, P less than 0.001) was found between plasma testosterone and the HCG and a rising trend in plasma testosterone was observed with increasing gestation. These results suggest that molar trophoblast is probably the major source of elevated testosterone in the maternal circulation.
mesh_terms: D000293:Adolescent; D000328:Adult; D006063:Chorionic Gonadotropin / Q000097:blood; D005260:Female; D005865:Gestational Age; D006801:Humans; D006828:Hydatidiform Mole / Q000097:blood* / Q000150:complications / Q000473:pathology; D008875:Middle Aged; D010048:Ovarian Cysts / Q000150:complications; D011247:Pregnancy; D013739:Testosterone / Q000097:blood*; D014594:Uterine Neoplasms / Q000097:blood* / Q000150:complications / Q000473:pathology; D014599:Uterus / Q000473:pathology
chemical_list: D006063:Chorionic Gonadotropin; D013739:Testosterone