Absence of hostility in outpatients after administration of halazepam--a new benzodiazepine.
A number of benzodiazepine have been shown to increase hostility and aggression. This study examines whether halazepam, a new benzodiazepine structurally very similar to diazepam, is associated with increases in hostility. Fifty-one adult outpatients in a double blind, 6 week study were randomly assigned either halazepam or placebo. Hostility was measured by changes in response on four different scales, the anger-hostility factor of the Patient Symptom Checklist and three MMPI hostility scales. The results of our study indicated that halazepam does not induce significant changes in hositility.
D000328:Adult; D001007:Anxiety / Q000188:drug therapy; D003975:Diazepam / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004311:Double-Blind Method; D005260:Female; D006791:Hostility / Q000187:drug effects*; D006801:Humans; D008950:MMPI; D008297:Male
D003975:Diazepam