[Somatotropin, antidot against phalloidin (author's transl)].
1. Somatotropin protects rats against a lethal dose of phalloidin (1.3 mg/kg). 2. Scanning electron microscopy has shown that 2 hours after phalloidin injection the liver from a somatotropin-pretreated rat is not significantly different to that from an untreated rat. Phalloidin alone caused complete destruction of the structure of the liver lobules. 3. Somatotropin does not prevent phalloidin uptake by the liver but slows down elimination. 4. The findings are discussed with respect to their therapeutic possibilities as somatropin protects rats against death also after phalloidin poisoning.
D000818:Animals; D000931:Antidotes / Q000627:therapeutic use; D013006:Growth Hormone / Q000494:pharmacology* / Q000627:therapeutic use; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D008297:Male; D009842:Oligopeptides / Q000506:poisoning*; D010590:Phalloidine / Q000378:metabolism / Q000506:poisoning*; D051381:Rats
D000931:Antidotes; D009842:Oligopeptides; D010590:Phalloidine; D013006:Growth Hormone
Somatotropin, Antidot gegen Phalloidin.