title: The susceptibility of cholesterol-depleted erythrocytes to saponin and sapogenin hemolysis.
abstract: The assumption that complex formation between erythrocyte membrane cholesterol and saponins or sapogenins is the cause for their hemolytic activity, was tested by measuring the susceptibility of cholesterol-depleted erythrocytes towards these hemolysins. For some of the hemolysins cholesterol depletion caused inhibition of hemolysis, for others an augmentation. The results suggest that cholesterol does not serve as a specific binding site for these hemolysins.
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000097:blood*; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000502:physiology*; D004912:Erythrocytes / Q000502:physiology*; D006461:Hemolysis / Q000187:drug effects*; D008297:Male; D008563:Membrane Lipids / Q000097:blood; D051381:Rats; D012502:Sapogenins / Q000494:pharmacology*; D012503:Saponins / Q000494:pharmacology*
chemical_list: D008563:Membrane Lipids; D012502:Sapogenins; D012503:Saponins; D002784:Cholesterol