title: [Effect of tetracycline on rat liver mitochondrial oxidative phosphorylation in vivo and in vitro under a varying body allowance of protein].
abstract: An investigation of the tetracycline action in vivo and in vitro showed it to reduce the rate of oxidative phosphorylation in the rat liver mitochondria which, with an increased concentration or a longer introduction of the drug, gives place to inhibition of respiration. These changes occur following introduction of 100 mg/kg by the 10th day of the experiment and of 20 mg/kg--by the 20th day. The protein-low background is a factor contributing to a speedier effect of tetracycline. Heat-treated tetracycline produces greater changes than does the native drug.
mesh_terms: D000818:Animals; D002751:Chlortetracycline / Q000494:pharmacology; D003864:Depression, Chemical; D004044:Dietary Proteins / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects*; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D011488:Protein Deficiency / Q000378:metabolism; D051381:Rats; D013752:Tetracycline / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D004044:Dietary Proteins; D013752:Tetracycline; D002751:Chlortetracycline
vernacular_title: Vliianie tetratsiklina na okislitel'noe fosforilirovanie mitokhondrii pecheni krys v usloviiakh in vivo i in vitro pri razlichnoĭ obespechennosti organizma belkom.