[Effect of thyroid hormones and iodine ions on the amino acid incorporation into proteins of liver mitochondria].
The thyroxin-like effect of I2 and ICl on the 3H-glycine and and 14C-leucine incorporation into proteins of mitochondria isolated from the liver of thyroidectomized animals was demonstrated. Triiodthyronine and iodine-containing substances increased in vitro incorporation of labeled amino acids into proteins of isolated mitochondria. The stimulating effect of T3 and ICl was eliminated by olivomycine and chloramphenicol. The action of ICl in these reactions had a much shorter latent period in comparison with the T3 action. The effect of IC1 was expressed as soon as the 30th minute after the injection. The results obtained confirmed the supposition that under definite conditions iodine ions could imitate the effect of the thyroid hormones on the protein synthesis in the cell of animals; the problem of a possibility of thyroid hormones to realize its biological effect at the moelcular level with the aid of iodine ions is thus put forward.
D000818:Animals; D002701:Chloramphenicol / Q000494:pharmacology; D005998:Glycine / Q000378:metabolism*; D006728:Hormones / Q000494:pharmacology; D066298:In Vitro Techniques; D007455:Iodine / Q000494:pharmacology*; D007553:Isotope Labeling; D007930:Leucine / Q000378:metabolism*; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism*; D009848:Olivomycins / Q000494:pharmacology; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D013974:Thyroxine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D014284:Triiodothyronine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D014316:Tritium
D006728:Hormones; D011506:Proteins; D014284:Triiodothyronine; D014316:Tritium; D009848:Olivomycins; D002701:Chloramphenicol; D007455:Iodine; D007930:Leucine; D013974:Thyroxine; D005998:Glycine
Vliianie tireoidnykh gormonov i ionov ĭoda na vkliuchenie aminokislot i belki mitokhondrii pecheni.