title: Comparison of in vitro dissolution and in vivo bioavailability of methaqualone tablets in humans.
abstract: Two methaqualone tablets that exhibited different in vitro dissolution rates were administered to 11 normal healthy male volunteers. Serial blood samples were withdrawn following administration of each tablet, and plasma methaqualone concentrations were determined by an established spectrophotofluormetric assay. Both tablets produced virtually identical plasma concentration versus time profiles in humans, and no statistically significant differences in either the rate or extent of drug absorbed were detected. The results indicate that there is no correlation between in vivo bioavailability and the modified NF in vitro dissolution test used.
mesh_terms: D000328:Adult; D001682:Biological Availability; D006801:Humans; D008297:Male; D008702:Methaqualone / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D012995:Solubility; D013607:Tablets
chemical_list: D013607:Tablets; D008702:Methaqualone