title: Recurrent unipolar depressions with a 48-hour cycle: report of a case.
abstract: Since 1804 there have been twelve case reports of patients with mood disorders showing a regular periodicity of 48 hours, eight bipolar and four unipolar. This paper describes an additional patient, a 57-year-old man with a 48-hour unipolar cycle. Although his 24-hour serum cortisol pattern was abnormal, there were few clear-cut biological abnormalities. Possible mechanisms are discussed, and comparisons made with previous reports of similar patients.
mesh_terms: D000305:Adrenal Cortex Hormones / Q000378:metabolism; D001683:Biological Clocks; D002940:Circadian Rhythm; D003863:Depression / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D010507:Periodicity; D012008:Recurrence; D012890:Sleep
chemical_list: D000305:Adrenal Cortex Hormones