title: [Effect of thyroxine and thyroidectomy on the activity of adenylate deaminase in the tissues of guinea pigs].
abstract: The authors studied the influence of thyroxin and thyroidectomy on adenylate deaminase activity in the liver, the myocardium, the brain and the skeletal muscles of guinea pigs. Thyroxin used in normal animals (200 microgram/100 g of body weight for 7 days) failed to alter the enzymatic activity in the tissues under study, whereas in thyroidectomized guinea pigs (50 microgram/100 g of body weight at the same interval)--it enhanced this activity. Thyroidectomy diminished the adenylate deaminase activity in the skeletal muscles and considerably increased it in the myocardium and in the brain.
mesh_terms: D000659:AMP Deaminase / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology; D003641:Deamination; D006168:Guinea Pigs; D006728:Hormones / Q000494:pharmacology; D008099:Liver / Q000201:enzymology; D009132:Muscles / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology; D009709:Nucleotide Deaminases / Q000378:metabolism*; D013268:Stimulation, Chemical; D013965:Thyroidectomy; D013974:Thyroxine / Q000494:pharmacology*
chemical_list: D006728:Hormones; D009709:Nucleotide Deaminases; D000659:AMP Deaminase; D013974:Thyroxine
vernacular_title: Vliianie tiroksina i tireoidektomii na aktivnost' adenilatdezaminazy v tkaniakh morskikh svinok.