title: [Cephazolin and cephapirin circulation in the blood of rabbits].
abstract: Circulation of 2 semi-synthetic cephalosporins, i. e. cephazoline and cephapyrine in the blood of rabbits after their intramuscular administration in single doses of 5 and 20 mg/kg was studied. It was found that the antibiotics were well adsorbed into the blood. Their maximum blood levels were achieved 15--30 minutes after administration. Cephazoline provided a higher blood level persisting for longer periods of time as compared to cephapyrine. The value of the time of the two-fold decrease in the cephazoline blood level was higher. A four-fold increase in the dose of the cephalosporines resulted in an increase in their blood levels but did not induce any significant increase in the time of their circulation.
mesh_terms: D000818:Animals; D001702:Biopharmaceutics; D002437:Cefazolin / Q000097:blood*; D002511:Cephalosporins / Q000097:blood*; D002514:Cephapirin / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D007273:Injections, Intramuscular; D007700:Kinetics; D008297:Male; D011817:Rabbits; D013997:Time Factors
chemical_list: D002511:Cephalosporins; D002514:Cephapirin; D002437:Cefazolin
vernacular_title: Tsirkuliatsiia tsefazolina i tsefapirina v krovi u krolikov.