title: Mechanisms of vascular changes in skeletal muscle during asphyxia in the cat.
abstract: Vascular responses in the hindlimb muscles of anesthetized paralyzed cats during systemic asphyxia were studied. The cats were ventilated with 10% O2-10% CO2-80% N2 for 10-20 min periods, while blood flow to the skinned hindlimb was monitored (electromagnetic flowmeter). Mean arterial pressure rose and hindlimb flow typically fell during asphyxia, implying increased vascular resistance. After sympathetic denervation of the hindlimb, resistance increased  in some groups of animals, and did not change in others during asphyxia. Functional adrenalectomy did not alter these response characteristics. Resistance also did not changes significantly if the control resistance was first increased to the predenervation level by electrically pacing the lumbar sympathetic chain. In contrast, pronounced vasodilatation occurred during asphyxia after blocking of the alpha receptors in the hindlimb (phenoxybenzamine) or after systemic catecholamine depletion (reserpine). We conclude that the vasoconstriction in innervated muscle during asphyxia was caused in part by increased discharge of sympathetic constrictor nerves to the muscle vasculature, with augmentation from a humoral alpha agonist of nonadrenal origin, possibly norepinephrine released from sympathetic nerves throughout the body.
mesh_terms: D000313:Adrenal Medulla / Q000502:physiology*; D000818:Animals; D002415:Cats; D005260:Female; D006614:Hindlimb; D000860:Hypoxia; D008297:Male; D009132:Muscles / Q000098:blood supply*; D012039:Regional Blood Flow; D013564:Sympathetic Nervous System / Q000502:physiology*; D014661:Vasoconstriction; D014666:Vasomotor System / Q000502:physiology*