title: [Specific protection by sulfhydryl groups against inhibition of urease by hypoglycaemic drugs (author's transl)].
abstract: The effect of oral hypoglycaemic drugs, derivatives of sulphonylurea, upon urease has been studied. These compounds, structurally connected to urea, produce a competitive inhibition of enzyme activity with respect to substrate. Glutathioné (reduced form) and cysteine prevent inactivation of enzyme by sulphonylurea, whereas-oxidated glutathione and cysteine do not. The same phenomenon occurs in enzyme preparations inhibited by p-hydroxymercuribenzoate. The role of sulfhydryl groups in the formation of enzyme-substrate complex is discussed.
mesh_terms: D002747:Chlorpropamide / Q000494:pharmacology*; D003545:Cysteine / Q000494:pharmacology*; D004347:Drug Interactions; D004789:Enzyme Activation / Q000187:drug effects*; D005978:Glutathione / Q000494:pharmacology*; D006801:Humans; D006902:Hydroxymercuribenzoates / Q000494:pharmacology; D014044:Tolbutamide / Q000494:pharmacology*; D014510:Urease / Q000037:antagonists & inhibitors*
chemical_list: D006902:Hydroxymercuribenzoates; D014044:Tolbutamide; D014510:Urease; D005978:Glutathione; D003545:Cysteine; D002747:Chlorpropamide
vernacular_title: Efecto protector de grupos sulfhidrilos en la inhibición de la ureasa por agentes hipoglucemiantes derivados de la sulfonilurea.