title: Relative bioavailability of meprobamate tablets in humans.
abstract: The relative bioavailability of 400-mg meprobamate tablets manufactured by 11 different firms was evaluated in two groups of healthy male subjects. Each group of six subjects received a reference standard product and five test products given at 1-week intervals. Plasma meprobamate concentrations at 1, 2, 3, 4, 6, 8, 10, 24, and 32 hr after dosing were determined using a GLC assay. Analysis of variance of the plasma level--time profiles revealed no statistically significant differences between any of the products in terms of plasma levels at the various sample times, time of peak plasma level, peak plasma level, and area under the plasma level--time curve. It was concluded that the 11 400-mg products could be considered bioequivalent.
mesh_terms: D000328:Adult; D001682:Biological Availability; D006801:Humans; D008297:Male; D008620:Meprobamate / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D012995:Solubility; D013607:Tablets; D013997:Time Factors
chemical_list: D013607:Tablets; D008620:Meprobamate