Conditioning under carbolonium bromide and D--tubocurarine chloride paralysis.
The findings of past research using d-tubocurarine chloride as a control procedure in heart rate conditioning have been equivocal. The present experiment compared classical heart rate conditioning under neuromuscular blockade by d-tubocurarine chloride, and a pharmacologically more specific blocker, carbolonium bromide. Both groups were compared to a placebo condition. The results indicated that carbolonium bromide and placebo treated animals acquired deceleratory cardiac conditional responses, but animals treated with d-tubocurarine chloride did not. Unconditional acceleratory responses were found in groups. The findings were discussed in relation to classical conditioning and the psychopharmacology of neuromuscular blockade.
D000818:Animals; D002219:Carbamates / Q000494:pharmacology; D002794:Choline / Q000031:analogs & derivatives* / Q000494:pharmacology; D003214:Conditioning, Classical / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects*; D008297:Male; D009466:Neuromuscular Blocking Agents; D010919:Placebos; D051381:Rats; D014403:Tubocurarine / Q000494:pharmacology*
D002219:Carbamates; D009466:Neuromuscular Blocking Agents; D010919:Placebos; D002794:Choline; D014403:Tubocurarine