title: [Antimutagenic and antiteratogenic properties of dimexide (DMSO)].
abstract: The influence of dimexide (dimethylsulphoxide, DMSO) on the manifestation of teratogenic and embryolethal properties and mutagenic effect of pyrimethamine (antimalarial drug) and 6-mercaptopurine (antitumoral compound) has been examined. Under the conditions of preliminary action of dimexide the embryolethal and teratogenic activity of the drugs studied reduced on the 13th day of rat embryos; the level of cytogenic effect of these compounds on rat males bone marrow cells also reduced.
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000517:prevention & control*; D000782:Aneuploidy; D000818:Animals; D002869:Chromosome Aberrations; D004121:Dimethyl Sulfoxide / Q000627:therapeutic use*; D005260:Female; D008431:Maternal-Fetal Exchange; D015122:Mercaptopurine / Q000037:antagonists & inhibitors*; D009153:Mutagens / Q000037:antagonists & inhibitors*; D011247:Pregnancy; D011739:Pyrimethamine / Q000037:antagonists & inhibitors*; D051381:Rats; D013723:Teratogens / Q000037:antagonists & inhibitors
chemical_list: D009153:Mutagens; D013723:Teratogens; D015122:Mercaptopurine; D004121:Dimethyl Sulfoxide; D011739:Pyrimethamine
vernacular_title: Issledovanie antimutagennykh i antiteratogennykh svoĭstv dimeksida (DMSO).