title: Exercise tolerance test. Single-sample screening technique to rule out growth-hormone deficiency.
abstract: Parent-directed vigorous exercise was evaluated as a screening test for adequacy of pituitary growth-hormone release in 57 short-statured children. This method obviated the need for pharmacologic provocative testing in all but the four children with growth-hormone deficiency. In 92% of the euendocrine children, the immediate postexercise venous sample demonstrated an adequate growth-hormone level. Vigorous physical exercise after an 8- to 12- hour fast with a single postexercise serum growth-hormone sample is a reliable, safe, and cost-effective screening test for growth-hormone deficiency.
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D006130:Growth Disorders / Q000175:diagnosis* / Q000209:etiology; D013006:Growth Hormone / Q000032:analysis / Q000172:deficiency*; D006801:Humans; D007018:Hypopituitarism / Q000175:diagnosis; D008297:Male; D005082:Physical Exertion
chemical_list: D013006:Growth Hormone