Retrograde coronary blood flow after mannitol in intact anesthetized dogs.
In control dogs mannitol produced a moderate increase in coronary blood flow, a decrease in coronary vascular resistance, and a moderate increase in cardiac output. In dogs with coronary occlusion mannitol increased retrograde coronary blood flow (+25%) and collateral conductance suggesting increased blood availability to ischemic myocardium.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects*; D004285:Dogs; D006339:Heart Rate / Q000187:drug effects; D008353:Mannitol / Q000494:pharmacology*; D014655:Vascular Resistance / Q000187:drug effects
D008353:Mannitol