title: Immunohistologic analysis of fetal and dermatosparactic calf and sheep skin with antisera to procollagen and collagen type I.
abstract: Immunofluorescent analysis of bovine and sheep skin using antibodies to the biosynthetic precursor pn-collagen type I, demonstrated that the localization of pn-collagen is restricted to the stratum papillare in adult skin. In contrast, antibodies against pn-collagen type I stained the whole dermis in skin obtained from dermatosparactic cattle and sheep. Electron microscopy of dermatosparactic sheep skin stained with ferritin-labeled anti-pn-collagen type I antibodies further demonstrated that pn-collagen molecules are the structural components of the unusual, twisted collagen fïbers observed in dermatosparactic skin.
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000378:metabolism*; D003094:Collagen / Q000096:biosynthesis* / Q000276:immunology; D007106:Immune Sera; D008968:Molecular Conformation; D011347:Procollagen / Q000096:biosynthesis* / Q000276:immunology; D012756:Sheep; D012757:Sheep Diseases / Q000378:metabolism*; D012867:Skin / Q000378:metabolism* / Q000648:ultrastructure; D012871:Skin Diseases / Q000378:metabolism / Q000662:veterinary*
chemical_list: D007106:Immune Sera; D011347:Procollagen; D003094:Collagen