title: Synthesis and antiallergic activity of some mono- and disubstituted xanthone-2-carboxylic acids.
abstract: A series of xanthone-2-carboxylic acids, substituted mainly with electron-withdrawing groups, has been synthesized and assayed for antiallergic activity, using the passive cutaneous anaphylaxis (PCA) reaction in the rat. The effect of substituent type and substitution pattern on PCA neutralizing capacity is presented.
mesh_terms: D000818:Animals; D005260:Female; D006967:Hypersensitivity / Q000188:drug therapy*; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D051381:Rats; D013329:Structure-Activity Relationship; D014970:Xanthines / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D014970:Xanthines