The liquefaction (oncolysis) of malignant gliomas by a non pathogenic Clostridium.
Vascular glioblastomas become liquefied when contaminated with spores of the non-pathogenic Clostridium butyricum M 55. The spores are administered by intracarotid injection. The oncolysis is complete one week after injection. The glioblastoma is converted into a brain abscess which is then operated on appropriately. Forty nine patients have been treated in this manner. The rate of recurrence, however, remained uninfluenced.
D000328:Adult; D001922:Brain Abscess / Q000209:etiology / Q000601:surgery; D001932:Brain Neoplasms / Q000150:complications / Q000628:therapy*; D003013:Clostridium / Q000648:ultrastructure; D005910:Glioma / Q000150:complications / Q000628:therapy*; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local; D013171:Spores, Bacterial