The effect of combination chemotherapy on the reticuloendothelial system in man.
The effect of adjuvant combination chemotherapy (vincristine, CCNU/MeCCNU, 5-fluorouracil) on the phagocytic and catabolic properties of the reticuloendothelial system (RES) was studied in 4 patients before and during the anticancer treatment. The results indicate a transient impairment of both these functions, more prolonged with regard to phagocytosis. No significant changes were noted in the mobile macrophage system. This suggests that chemotherapy induces a depression especially of the stationary macrophage populations in the liver, spleen and bone-marrow.
D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects; D006801:Humans; D008130:Lomustine / Q000009:adverse effects; D008264:Macrophages / Q000187:drug effects / Q000502:physiology; D008297:Male; D008875:Middle Aged; D012157:Mononuclear Phagocyte System / Q000187:drug effects* / Q000503:physiopathology; D009369:Neoplasms / Q000188:drug therapy* / Q000503:physiopathology; D010587:Phagocytosis / Q000187:drug effects; D012673:Semustine / Q000009:adverse effects; D014750:Vincristine / Q000009:adverse effects
D000970:Antineoplastic Agents; D012673:Semustine; D014750:Vincristine; D008130:Lomustine; D005472:Fluorouracil