Semiautomated method for determining ferrous sulfate in pharmaceuticals: collaborative study.
A semiautomated colorimetric method is described for determining ferrous sulfate in tablets, capsules, and elixirs. The method involves the formation of an orange-red complex between 1,10-phenanthroline and ferrous ion. Collaborators were supplied with 3 solid composites and one liquid sample. Two of the solid composites were prepared from commerical tablets of different dosage and one from commercial timed-release capsules; the fourth sample was an elixir. The results of the automated analyses for ferrous sulfate agreed well with those of the applicable USP method. No interference was found from ferric iron or from the red and green coloring used on coated tablets. The method has been adopted as official first action.
D001322:Autoanalysis / Q000379:methods; D004304:Dosage Forms; D005296:Ferrous Compounds / Q000032:analysis*; D007501:Iron / Q000032:analysis*; D013431:Sulfates / Q000032:analysis; D013607:Tablets
D004304:Dosage Forms; D005296:Ferrous Compounds; D013431:Sulfates; D013607:Tablets; D007501:Iron