Isolation of a factor with toxohormone properties from mouse tumor cells in culture.
A small molecular weight factor with  potent toxohormone activity was recovered from the serum-free culture supernatant of mouse MBQA fibrosarcoma cells. The factor depressed plasma-bound iron levels in mice and inhibited cell-free protein synthesis in microgram doses. Preliminary characterizations suggest that the active material is a small peptide.
D000818:Animals; D002460:Cell Line; D004731:Endotoxins / Q000378:metabolism* / Q000494:pharmacology; D005354:Fibrosarcoma / Q000378:metabolism; D066298:In Vitro Techniques; D007501:Iron / Q000097:blood; D051379:Mice; D009132:Muscles / Q000187:drug effects; D009363:Neoplasm Proteins / Q000378:metabolism* / Q000494:pharmacology; D010455:Peptides / Q000378:metabolism; D011132:Polyribosomes / Q000187:drug effects; D014176:Protein Biosynthesis; D051381:Rats; D012513:Sarcoma, Experimental / Q000378:metabolism*
D004731:Endotoxins; D009363:Neoplasm Proteins; D010455:Peptides; C010355:toxohormone; D007501:Iron