Absence of beta mRNA in beta0-thalassemia in Kurdish Jews.
We report the characterization of the amount of beta mRNA in a Kurdish Jewish population with beta0-thalassemia using the same methods employed for characterization of the Catania and Ferrara beta0 patients. We found very low amounts of beta mRNA sequences, consistent with the presence of beta0-thalassemia of the beta mRNA-negative population type. In addition, no globin gene deletion was detected that could account for the absence of beta mRNA.
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004247:DNA; D005914:Globins / Q000096:biosynthesis / Q000235:genetics; D006801:Humans; D007585:Jews; D009693:Nucleic Acid Hybridization; D012333:RNA, Messenger / Q000097:blood*; D013789:Thalassemia / Q000097:blood*
D012333:RNA, Messenger; D005914:Globins; D004247:DNA