title: Halothane, tracheal compliance and upper-airway mechanoreceptors.
abstract: This study was designed to define the effects of halothane on the compliance of the trachea. An isolated in-situ tracheal preparation was studied in 14 mongrel dogs anesthetized with pentobarbital. Compliance of the closed tracheal segment was measured with continuous intraluminal pressure recordings during repeated injections of known volumes of air: Slow-adapting neural activity observed in paratracheal branches of the recurrent laryngeal nerve accurately reflected pressure in the tracheal segment. Halothane at 0.5--4.0 per cent concentrations caused a significant (P less than 0.001) average 10 per cent increase in the compliance of the trachea. Stimulation of the efferent vagus caused a significant (P less than 0.001) average 8 per cent decrease in compliance of the trachea. After exposure to halothane, vagal stimulation still caused a significant decrease in compliance of the trachea.
mesh_terms: D000403:Airway Resistance / Q000187:drug effects; D000818:Animals; D004285:Dogs; D004558:Electric Stimulation; D006221:Halothane / Q000008:administration & dosage / Q000494:pharmacology*; D008170:Lung Compliance / Q000187:drug effects; D014132:Trachea / Q000187:drug effects*; D014630:Vagus Nerve
chemical_list: D006221:Halothane