Effect of age and sex on the association constant and binding capacity of chicken serum for corticosteroid.
In two experiments, the blood of White Rock chickens was collected at 6 intervals from the time they were 2 to 140 days old. The effects of age, sex of the bird, and removal of exogenous steroids (stripping) on the association constant (Ka), and the binding capacity (CBGBC) for corticosterone in the serum were measured. The Ka of the serum declined when the chickens were between 84 and 140 days old. Stripping increased the Ka only when all chickens were 2 days old and when the females were 140 days old. The CBGBC was highest in all chickens when they were 28 to 56 days old. In general, CBGBC was higher in serum of males than in that of females, but was reduced to a greater extent by stripping in males than in females. These results indicate that the bound to free ratio for corticosteroids should be highest when the chickens are 28 to 56 days old, when both Ka and CBGBC are highest.
D000305:Adrenal Cortex Hormones / Q000097:blood*; D000367:Age Factors; D000818:Animals; D002645:Chickens / Q000097:blood*; D003345:Corticosterone / Q000097:blood / Q000302:isolation & purification; D003348:Cortisone / Q000302:isolation & purification; D005260:Female; D006854:Hydrocortisone / Q000302:isolation & purification; D008297:Male; D011374:Progesterone / Q000302:isolation & purification; D012737:Sex Factors; D014156:Transcortin / Q000378:metabolism*
D000305:Adrenal Cortex Hormones; D011374:Progesterone; D014156:Transcortin; D003348:Cortisone; D003345:Corticosterone; D006854:Hydrocortisone