Metocurine in infants and children: neuromuscular and clinical effects.
A cumulative dose--response curve for metocurine based on body weight was determined in 30 infants and children during halothane (1.2 per cent inspired), nitrous oxide and oxygen (60/40 per cent) anesthesia. The mean and range of twitch depression and time for recovery from maximal neuromuscular blockade were not significantly different over an age range from newborn to 7 years. Metocurine is twice as potent as d-tubocurarine in children, and their requirement is more than that for adults. The rate of recovery from metocurine in children was the same as that from d-tubocurarine. In another 30 children, use of metocurine at a large dose (0.5 mg/kg) for endotracheal intubation caused no significant change in blood pressure or pulse rate. Cardial arrhythmias were not seen.
D001794:Blood Pressure / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D006221:Halothane; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009469:Neuromuscular Junction / Q000187:drug effects; D009609:Nitrous Oxide; D013874:Thiopental; D014403:Tubocurarine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology
D013874:Thiopental; D009609:Nitrous Oxide; D006221:Halothane; D014403:Tubocurarine