title: Family studies of ocular manifestations in arthritis.
abstract: To determine the hereditary and clinical patterns, nine patients from three families with different systemic and ocular rheumatoid diseases were examined ophthalmologically and medically. Three types of HLA-B27 associated anterior uveitis were seen. While HLA-B27 linked genes predispose the carrier to acute anterior uveitis (AAU) frequently recurring or chronic anterior uveitis may develop if an immune-complex disease such as Rheumatoid arthritis coexists. Hereditary factors may dispose patients to rheumatoid episcleritis, scleritis and keratitis.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000235:genetics* / Q000276:immunology; D005128:Eye Diseases / Q000235:genetics* / Q000276:immunology; D005132:Eye Manifestations; D005260:Female; D006680:HLA Antigens; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D012446:Sacroiliac Joint; D012590:Sclera; D014605:Uveitis / Q000235:genetics / Q000276:immunology
chemical_list: D006680:HLA Antigens