Anti-inflammatory and antiproteolytic properties of 2-[acyl-N-(substituted benzylidene)hydrazino]5-phenyltetrazoles.
Ten 2-[acyl-N-(substituted benzylidene)hydrazino]5-phenyltetrazoles were synthesized, characterized and evaluated for anti-inflammatory and antiproteolytic activity. The protection afforded by these tetrazoles at a dose of 100 mg/kg i.p., against carrageenin-induced edema in rats, ranged from 11 to 46%. Oxyphenbutazone (40 mg/kg i.p.), and hydrocortisone (10 mg/kg i.p.), used as reference drugs, exhibited protection of 54 and 47%, respectively. The antiproteolytic activity of these tetrazoles, as reflected by their ability to inhibit trypsin-induced hydrolysis of bovine serum albumin, ranged from 17 to 57%. The antiproteolytic activity was found to be unrelated to the anti-inflammatory activity possessed by these tetrazoles.
D000818:Animals; D000893:Anti-Inflammatory Agents; D001393:Azoles / Q000627:therapeutic use*; D002351:Carrageenan; D004353:Drug Evaluation, Preclinical; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D006854:Hydrocortisone / Q000627:therapeutic use; D010113:Oxyphenbutazone / Q000627:therapeutic use; D011480:Protease Inhibitors; D051381:Rats; D013777:Tetrazoles / Q000008:administration & dosage / Q000627:therapeutic use*
D000893:Anti-Inflammatory Agents; D001393:Azoles; D011480:Protease Inhibitors; D013777:Tetrazoles; D002351:Carrageenan; D010113:Oxyphenbutazone; D006854:Hydrocortisone