Correlation of chemical structure and taste in the cyclamate series and the steric nature of the chemoreceptor site.
The requirements of compounds in the cyclamate series for sweet taste stimulation are: synclinal conformation between NH and SO in the aminosulphonate group, length less than 0.7 nm of the group on the nitrogen, and hydrophobic character of the latter group. A hypothetical receptor site for these compounds should have a spatial barrier at a distance of about 0.7 nm from the nitrogen interaction point with the receptor site, and a hydrophobic interaction area between the nitrogen interaction point and the barrier.
D055598:Chemical Phenomena; D002621:Chemistry; D003494:Cyclamates / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D008958:Models, Molecular; D009584:Nitrogen; D013329:Structure-Activity Relationship; D013649:Taste; D013650:Taste Buds / Q000378:metabolism*
D003494:Cyclamates; D009584:Nitrogen