[Possibilities to avoid adsorption of physiological substances during charcoal hemoperfusion (author's transl)].
For the clinical use of charcoal in intoxications the loss of normal substances out of the organism must be avoided. In order to study the possibility of pretreating the charcoal with certain substances without influencing the adsorptive capacity of toxic metabolic products we perfused over 70 g uncoated charcoal for 6 h: 500 mg creatinine, 1 g and 20 g barbital, 500 mg bromthalein, 1 g raffinose resp. 1 g inulin per litre physiological saline in different combinations and found the following results: 1. In low and middle molecular weight levels there is no competition between two substances. 2. By preadsorption of the charcoal with a low or middle molecular weight substance, the adsorptive capacity of other substances is not influenced.
D000042:Absorption; D001667:Binding, Competitive; D002606:Charcoal / Q000627:therapeutic use*; D006501:Hepatic Encephalopathy / Q000628:therapy; D008970:Molecular Weight; D011041:Poisoning / Q000628:therapy*; D014511:Uremia / Q000628:therapy
D002606:Charcoal
Möglichkeiten zur Vermeidung der Adsorption physiologischer Substanzen bei der Aktivkohlehämoperfusion.