Effect of meclofenamate on renal vascular resistance in early Goldblatt hypertension in conscious and anesthetized dog.
Blood pressure and renal blood flow were monitored in conscious normotensive (N) and 2-kidney Goldblatt hypertensive (H) dogs. Plasma renin activity was signficantly increased 4--8 days after partial renal artery occlusion. At this time intravenous administration of meclofenamate, 5 mg/kg, had no effect on blood pressure in the N or H or on renal vascular resistance in the N or in the H (contralateral kidney). The renal vasoconstrictor response to angiotensin II was increased in duration by meclofenamate in both the N and H. In contrast to the absence of an effect of meclofenamate on renal vascular resistance in the conscious dog, the synthesis inhibitor caused a consistent increase in RVR in the N and H when they were anesthetized in the terminal experiment. These results suggest the lack of an influence of prostaglandins on renal vascular resistance in the unaffected kidney in Goldblatt hypertension.
D000768:Anesthesia, General; D000818:Animals; D001795:Blood Pressure Determination; D004285:Dogs; D006977:Hypertension, Renal / Q000503:physiopathology*; D006978:Hypertension, Renovascular / Q000503:physiopathology*; D007275:Injections, Intravenous; D007668:Kidney / Q000098:blood supply*; D008469:Meclofenamic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D011453:Prostaglandins / Q000502:physiology*; D012083:Renin / Q000097:blood; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects*; D062367:ortho-Aminobenzoates / Q000494:pharmacology*
D011453:Prostaglandins; D062367:ortho-Aminobenzoates; D008469:Meclofenamic Acid; D012083:Renin