Amino acid transport properties of erythrocytes from normal newborn lambs and lambs with an inherited defect in amino acid transport.
An amino acid transport defect which occurs in the erythrocytes of adult sheep is also present in foetal erythrocytes from newborn lambs which have inherited the lesion. The transport defect in erythrocytes from adult sheep is associated with high intracellular levels of ornithine and lysine and a markedly diminished GSH concentration. Although the lesion in foetal cells also results in the accumulation of ornithine and lysine, the intracellular GSH concentration is only moderately diminished.
D000409:Alanine / Q000097:blood; D000592:Amino Acid Metabolism, Inborn Errors / Q000097:blood*; D000596:Amino Acids / Q000097:blood*; D000818:Animals; D000831:Animals, Newborn; D001119:Arginase / Q000097:blood; D001120:Arginine / Q000097:blood; D004912:Erythrocytes / Q000378:metabolism*; D005978:Glutathione / Q000097:blood; D008239:Lysine / Q000097:blood; D009952:Ornithine / Q000097:blood; D010649:Phenylalanine / Q000097:blood; D012756:Sheep
D000596:Amino Acids; D010649:Phenylalanine; D001120:Arginine; D009952:Ornithine; D001119:Arginase; D005978:Glutathione; D008239:Lysine; D000409:Alanine