Structure-toxicity relationships of iodinated aromatic carbonates and related compounds.
Structure-toxicity relationships of iodinated aromatic carbonates, carbamates, and esters are presented. The approximate lethal dose of intraperitoneal injections in mice was used for toxicity determinations. Increasing the alkyl portion of the molecules reduced toxicity. m-Amino and m-acetamido groups also reduced toxicity. Carbonates were preferred X-ray contrast because of their low viscosity and more rapid elimination.
D000818:Animals; D002254:Carbonates / Q000633:toxicity*; D003287:Contrast Media / Q000633:toxicity*; D007928:Lethal Dose 50; D051379:Mice; D013329:Structure-Activity Relationship
D002254:Carbonates; D003287:Contrast Media