Amobarbital metabolism in man: N-glucoside formation.
N-Hydroxyamobarbital, the compound previously proposed as the second major metabolite of amobarbital was synthesized. The metabolite was shown not to be N-hydroxyamobarbital. NMR and MS analyses on the metabolite suggested it could be a derivative of N-beta-D-glucopyranoside. This proposed structure was confirmed by comparison with the spectral data of synthetic amobarbital-N-methyl-N-2,3,4,6-tetraacetyl-beta-D-glucopyranoside.
D000654:Amobarbital / Q000378:metabolism*; D055598:Chemical Phenomena; D002621:Chemistry; D005960:Glucosides / Q000096:biosynthesis*; D006027:Glycosides / Q000096:biosynthesis*; D006801:Humans
D005960:Glucosides; D006027:Glycosides; D000654:Amobarbital