Glucose-induced hyperkalemia with normal aldosterone levels. Studies in a patient with diabetes mellitus.
A diabetic patient exhibited glucose-induced hyperkalemia despite normal plasma and urinary aldosterone levels. The patient received no diuretics, was not acidotic, and had a creatinine clearance of 39 ml/min. Insulin or pharmacologic doses of desoxycorticosterone acetate eliminated the glucose-induced hyperkalemia. Normal aldosterone levels may be insufficient to protect certain diabetic patients from glucose-induced hyperkalemia.
D000368:Aged; D000450:Aldosterone / Q000097:blood / Q000378:metabolism* / Q000652:urine; D003900:Desoxycorticosterone / Q000008:administration & dosage; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000378:metabolism*; D005947:Glucose / Q000009:adverse effects*; D006801:Humans; D006947:Hyperkalemia / Q000139:chemically induced* / Q000188:drug therapy; D007328:Insulin / Q000008:administration & dosage; D008297:Male
D007328:Insulin; D003900:Desoxycorticosterone; D000450:Aldosterone; D005947:Glucose