[Effect of pinocembrin on the course of experimental candida infections in mice].
Pinocembrin (5,7-dihydroxy-flavanon)--a component of the bee product propolis--was tested for its in vivo activity against Candida albicans in mice. It was shown that the intravenous infection of AB-Jena mice with 2.5 X 10(5) Candida albicans cells was a very suitable model. Despite of treatment with pinocembrin at daily doses of 100 mg/kg body weight the animals as well as the controls died between the 6th and 24th day after beginning. On the other hand the animals treated with 5 mg/kg amphotericin B survived the test-period of 30 days. The question of effectiveness of pinocembrin in vivo should be cleared up in further pharmacokinetic investigations.
D000666:Amphotericin B / Q000627:therapeutic use; D000818:Animals; D002177:Candidiasis / Q000188:drug therapy*; D004341:Drug Evaluation; D005419:Flavonoids / Q000627:therapeutic use*; D051379:Mice
D005419:Flavonoids; D000666:Amphotericin B
Einfluss von Pinocembrin auf den Verlauf der experimentellen Candida-Infektion der Maus.