Influence of tocopherol on tumour cell oxygenation.
Tocopherol, a well known tissue anti-oxidant, given before local X-ray irradiation of 2 transplantable rat tumours was previously found to increase significantly the effect of irradiation. In the present study tocopherol did not influence the development of tumour necroses during growth of a transplantable rat hepatoma. The tumour tissue oxygenation of a transplantable rat sarcoma was neither found to be influenced by tocopherol. This suggests that an enhanced tumour radio-sensitivity by tocopherol is probably not explained by an influence on tumour cell oxygenation.
D000818:Animals; D000860:Hypoxia / Q000188:drug therapy; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy* / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects*; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012513:Sarcoma, Experimental / Q000188:drug therapy* / Q000378:metabolism; D014810:Vitamin E / Q000494:pharmacology*
D011838:Radiation-Sensitizing Agents; D014810:Vitamin E