Perfusion rate dependent prostaglandin release from isolated rabbit kidneys.
Isolated rabbit kidneys were perfused with 37 degrees C Krebs-Henseleit solution aerated with 95% O2 + 5% CO2. Perfusion rate was varied from 1 to 10 ml/min. This was accompanied by parallel changes of perfusion pressure, prostaglandin excretion and release of radioactivity from kidneys with 14C-arachidonic acid incorporated into the tissue lipid pool. It is suggested that enhancement of perfusion rate raises the intrarenal pressure which increases renal prostaglandin release due to increased substrate availability.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D007668:Kidney / Q000378:metabolism*; D010477:Perfusion; D011453:Prostaglandins / Q000378:metabolism*; D011817:Rabbits
D011453:Prostaglandins