Effect of dialysable leukocytes extracts on antibody-dependent cellular cytotoxicity and lymphocyte Fc receptors.
Dialysable leukocyte extracts significantly inhibited the antibody-dependent cell-mediated cytotoxicity of normal human peripheral blood lymphocytes in both xenogeneic and allogenic assays. The inhibitory effect was dose-dependent. Fractions of dialysable leukocyte extracts separated on Sephadex G-25 column differed in their capacity to suppress cytotoxicity. Dialysable leukocyte extracts did not block EA-rosetting but inhibited the resynthesis of Fc receptors. Some explanations for the observed suppressive effect are discussed.
D000920:Antibody-Dependent Cell Cytotoxicity / Q000187:drug effects*; D001666:Binding Sites, Antibody / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007141:Immunoglobulin Fc Fragments; D008214:Lymphocytes / Q000276:immunology*; D012397:Rosette Formation; D014165:Transfer Factor / Q000494:pharmacology*
D007141:Immunoglobulin Fc Fragments; D014165:Transfer Factor