Denaturation of cytochrome P-450 by cyclophosphamide metabolites.
D000171:Acrolein / Q000494:pharmacology*; D000447:Aldehydes / Q000494:pharmacology*; D000818:Animals; D001711:Biotransformation; D003520:Cyclophosphamide / Q000031:analogs & derivatives* / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System; D007069:Ifosfamide / Q000494:pharmacology; D008862:Microsomes, Liver / Q000378:metabolism; D010752:Phosphoramide Mustards / Q000494:pharmacology; D011489:Protein Denaturation / Q000187:drug effects; D051381:Rats
D000447:Aldehydes; D010752:Phosphoramide Mustards; D000171:Acrolein; D003520:Cyclophosphamide; D003577:Cytochrome P-450 Enzyme System; D007069:Ifosfamide