title: A study of o-cresolphthalexon and its analogs as cholescintigraphic 111In carriers.
abstract: 111In has been complexed to a series of metal-complexing phthaleins and sulfonphthaleins, and the hepatobiliary excretion of the compounds were compared in rats. The highest biliary excretion was obtained with 111In-o-cresolphthalexon. In a normal human subject, sequential imaging with 111In-o-cresolphthalexon visualized his gallbladder, common bile duct, and the bowel from jejunum to rectum. The potential utility and limitation of this biliary scanning agent is discussed.
mesh_terms: D000328:Adult; D000818:Animals; D001659:Biliary Tract / Q000000981:diagnostic imaging* / Q000378:metabolism; D002614:Chelating Agents; D006801:Humans; D007204:Indium / Q000378:metabolism; D008099:Liver / Q000000981:diagnostic imaging* / Q000378:metabolism; D010635:Phenolphthaleins; D011868:Radioisotopes / Q000378:metabolism; D011877:Radionuclide Imaging; D051381:Rats; D013997:Time Factors
chemical_list: D002614:Chelating Agents; D010635:Phenolphthaleins; D011868:Radioisotopes; D007204:Indium; C017845:2-cresolphthalexon