title: Evidence for a 'silent allele' GLO0 at the glyoxalase I locus.
abstract: In a three-generation family, the segregation of an apparent silent allele at the GLO I locus in association with the rare HLA haplotype 'AW30-CW4-BW35' was observed in four members. In two cases the assumption of homozygosity at the GLO locus would lead to mother-child exclusions. Phenotypically, the GLO activity in the GLO0 carriers is clearly diminished.
mesh_terms: D000483:Alleles; D005260:Female; D005796:Genes; D008040:Genetic Linkage; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D007791:Lactoylglutathione Lyase / Q000235:genetics*; D008190:Lyases / Q000235:genetics*; D008297:Male; D010334:Paternity; D010375:Pedigree; D010641:Phenotype
chemical_list: D006680:HLA Antigens; D008190:Lyases; D007791:Lactoylglutathione Lyase