title: [Gardner's syndrome in familial popyposis: clinical contribution and etiopathogenetic, therapeutic and prognostic considerations].
abstract: Starting from one case of Gardner's syndrome of their own observation, and in light of Watne's results, the authors argue that in the syndrome just named--and in familial polyposis in a broader sense--genetic factors do not play a predominant role; rather, polyps seem to result from the prolonged action of noxious agents. At any rate, said action can be neutralized, and possibly prevented either with a surgical modification of the distal gut or by treatment with a chemical substance identified as ascorbic acid. In view of these considerations, the authors recommend preventive medical therapy.
mesh_terms: D005260:Female; D005350:Fibroma / Q000235:genetics; D006801:Humans; D007417:Intestinal Polyps / Q000235:genetics* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000601:surgery; D012983:Soft Tissue Neoplasms / Q000235:genetics / Q000601:surgery; D013577:Syndrome
vernacular_title: La sindrome di Gardner nella poliposi familiare: contributo clinico, considerazioni etio-patogenetiche, terapeutiche e prognostiche.