Apomorphine-induced locomotor stimulation in developing rats treated with 6-hydroxydopa.
Apomorphine-induced locomotor stimulation was investigated in the developing rat following injection with 6-hydroxydopa at birth. Treatment with 6-hydroxydopa potentiated locomotor responsiveness to apomorphine in the 20-day-old rat. The 6-hydroxydopa-treated animal at 30 days, however, was less sensitive to the drug than was the control. Apomorphine again elicited more locomotor stimulation in 6-hydroxydopa-treated animals than in the controls on day 50. These results suggest that the altered sensitivity of dopamine receptors induced with 6-hydroxydopa, is influenced by the onset of activity of other "inhibitory" neurons on day 30.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives*; D005260:Female; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D013268:Stimulation, Chemical
D004295:Dihydroxyphenylalanine; D001058:Apomorphine