title: [Preliminary results of polychemiotherapy and immunostimulant treatment with Corynebacterium parvum in tumors of the breast in the postoperative phase and advanced phase].
abstract: Difficulties still encountered in the coordinated interdisciplinary management of solid tumours in hospitals are discussed. Preliminary results obtained with a polychemical and immunostimulating protocol based on Corynebacterium parvum (introduced in 1973) in breast tumours immediately after surgery and in the advanced stage are presented. Two out of eight subjects with advanced forms died. Partial regression or a steady state were noted in the remainder. No locoregional recurrences or metastases were observed from 1 to 2 yr after the commencement of treatment in 22 patients treated in the immediate post-operative phase. These results are considered satisfactory, though a final evaluation would be premature. Stress is laid on the importance of immunostimulating management in the avoiding the immunodepression caused by the administration of drugs.
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001428:Bacterial Vaccines / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000601:surgery / Q000628:therapy*; D003352:Corynebacterium / Q000276:immunology*; D004359:Drug Therapy, Combination; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008875:Middle Aged; D011182:Postoperative Care
chemical_list: D000970:Antineoplastic Agents; D001428:Bacterial Vaccines
vernacular_title: Risultati preliminari di un trattamento polichemioterapico e immunostimolante con Corynebacterium parvum dei tumori della mammella in fase postoperatoria e in fase avanzata.