[Regulation of the renin-angiotensin-aldosterone system. Role of the prostaglandins].
PRA (in the supine and erect subject) and urinary sodium before and after acute treatment (100 mg i.m.) and chronic treatment (100 mg per os for 8 days) were examined in two groups of subjects with no signs of cardiovascular or renal disease. It was found that indomethacin, which is a well-known inhibitor of prostaglandin synthesis, reduced PRA levels in basal conditions and as a result of postural stimulation, without causing any appreciable change in urinary sodium. Regulation of the PRA on the part of the renal prostaglandins is postulated and its probable mechanisms discussed.
D000302:Adrenal Cortex / Q000502:physiology*; D000328:Adult; D000450:Aldosterone / Q000378:metabolism*; D000804:Angiotensin II / Q000096:biosynthesis*; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology; D007668:Kidney / Q000502:physiology*; D008875:Middle Aged; D009318:Natriuresis / Q000187:drug effects; D011187:Posture; D011453:Prostaglandins / Q000502:physiology*; D012083:Renin / Q000378:metabolism*
D011453:Prostaglandins; D000804:Angiotensin II; D000450:Aldosterone; D012083:Renin; D007213:Indomethacin
Regolazione del sistema renina-angiotensina-aldosterone. Ruolo delle prostaglandine.