Oestrogen treatment and subsequent pregnancy in two patients with severe hypergonadotrophic ovarian failure.
This report describes in detail the histological and hormonal findings in a patient with Turner's syndrome (45,XO) and a patient with premature menopause (46,XX), who both conceived after withdrawal or reduction of substitution therapy with oestrogens. The aetiology of severe hypergonadotrophic ovarian failure is discussed, and theories regarding a possible relationship between the oestrogen treatment and subsequent pregnancy are hypothesized.
D000328:Adult; D004964:Estriol / Q000652:urine; D004967:Estrogens / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008593:Menopause / Q000187:drug effects*; D008594:Menopause, Premature / Q000187:drug effects*; D010053:Ovary / Q000473:pathology; D010928:Placental Lactogen / Q000097:blood; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism; D011374:Progesterone / Q000097:blood; D014424:Turner Syndrome / Q000188:drug therapy*
D004967:Estrogens; D011374:Progesterone; D010928:Placental Lactogen; D004964:Estriol