[Changes in hepatocytes and the functional activity of the adrenal cortex in rats following administration of the pigment anthraquinone violet].
The response of hepatocytes and cells of adrenal cortex of males of white rats to a single introduction per os of sunflower oil or anthraquinone violet pigment (AVP), routinely used for the painting of plastics, was evaluated. 5 ml of sunflower oil or of AVP, prepared as oil suspension, were fed. After 1 or 24 hour introductions of oil, an increase in dividing ability of hepatocytes was observed, whereas after 6 or 72 hour introductions no difference from the control was registered. The introduction of oil caused a decrease of the functional activity of cells in fasciculata zone of adrenal cortex after 1, 6, 24 and 72 hours, as judged from changes in the nuclear volume. AVP in doses of 5.0 and 1.2 g/kg intensified hepatic polyploidy after 1 and 24 hours as compared with rats administered only the oil. After 6 and 72 hours, no difference from the control was registered. In the fasciculata zone of adrenal cortex, AVP in both the doses employed increased the functional activity of cells after 1, 6 and 24 hours. The nature of the response of hepatic cells on the introduction of the above substances presumably depends on the degree of adrenal cortex functional activity.
D000302:Adrenal Cortex / Q000187:drug effects* / Q000648:ultrastructure; D000814:Aniline Compounds / Q000494:pharmacology*; D000818:Animals; D000880:Anthraquinones / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects; D002467:Cell Nucleus; D004396:Coloring Agents / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000648:ultrastructure; D008297:Male; D011003:Ploidies / Q000187:drug effects; D051381:Rats
D000814:Aniline Compounds; D000880:Anthraquinones; D004396:Coloring Agents; C017009:anthraquinone violet
Ob al'teratsii gepatotsitov i funktsional'noĭ aktivnosti kory nadpochechnikov krys posle vvedeniia pigmenta fioletovogo antrakhinonovogo.