title: The effects of aminoethyl phosphonic acid on hepatic microsomal drug metabolism and ultrastructure of normal and cholesterol fed rats.
abstract: The effects of parenteral administration of aminoethyl phosphonic acid (AEP) on the liver microsomal drug metabolism and ultrastructure were studied in normal and 1% cholesterol-fed albino rats. AEP administration to rats fed a stock-diet resulted in decreased demethylation of aminopyrine with a concomitant fall in cytochrome P-450 level. Aniline hydroxylation remained unaltered. AEP injection to cholesterol-fed rats, caused marked reduction in both aminopyrine demethylation and aniline hydroxylation, with a significant increase in cytochrome P-450 level. AEP injection to both control and cholesterol-fed animals produced a modest increase in Bilirubin UDP-glucuronyl transferase. RNA:DNA ratio showed remarkable elevation in rats fed the cholesterol diet with AEP injection. AEP injection caused an atypical smooth endoplasmic reticulum and a marked loss of nuclear euchromatin. Effect of AEP was more pronounced in rats receiving the cholesterol-diet. AEP administration thus induces structural and drug metabolic enzyme alteration in liver.
mesh_terms: D000615:Aminoethylphosphonic Acid / Q000494:pharmacology*; D000632:Aminopyrine / Q000378:metabolism; D000814:Aniline Compounds / Q000378:metabolism; D000818:Animals; D001711:Biotransformation / Q000187:drug effects; D002791:Cholesterol, Dietary; D003640:Dealkylation; D004357:Drug Synergism; D006900:Hydroxylation; D008099:Liver / Q000187:drug effects / Q000648:ultrastructure*; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism*; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D051381:Rats
chemical_list: D000814:Aniline Compounds; D002791:Cholesterol, Dietary; D009943:Organophosphorus Compounds; D000632:Aminopyrine; D000615:Aminoethylphosphonic Acid