[The virostatic effect of adenine-arabinoside monophosphate. Experimental findings and preliminary clinical experiences].
Adenine arabinoside (Ara-A), a synthetic nucleoside, is an antiviral agent, which is effective against poxviruses and viruses of the herpes group. The monophosphate (Ara-AMP) has the great advantage of better solubility, compared to the parent compound. Experimental studies show the outstanding effect of Ara-AMP on the encephalitis by vaccinia-virus in white mice. Even after immunesuppression by total body irradiation, the survival rate of the Ara-AMP treated animals was significantly higher compared to the untreated controls. In experimental vaccinia-virus infections in rabbits, who had undergone total body irradiation. Ara-AMP has a favourable influence upon the course of the disease and the prognosis. Some clinical observations in children with immunesuppression, who suffered from generalized zoster of varicella-infections, are reported. Furthermore in cases of viral encephalitis Ara-AMP was successful. Controlled studies of a greater number of patients on the therapeutic value of Ara-AMP in infections with DNS-viruses are needed.
D000249:Adenosine Monophosphate / Q000627:therapeutic use*; D000818:Animals; D002648:Child; D002675:Child, Preschool; D004660:Encephalitis / Q000188:drug therapy; D005260:Female; D006561:Herpes Simplex / Q000188:drug therapy* / Q000209:etiology; D006562:Herpes Zoster / Q000188:drug therapy*; D006689:Hodgkin Disease / Q000150:complications; D006801:Humans; D007223:Infant; D007938:Leukemia / Q000150:complications; D008297:Male; D051379:Mice; D011817:Rabbits; D012995:Solubility; D014615:Vaccinia / Q000188:drug therapy / Q000209:etiology; D014740:Vidarabine / Q000627:therapeutic use*
D000249:Adenosine Monophosphate; D014740:Vidarabine
Untersuchungen zur virostatischen Wirkung von Adenin-Arabinosid-Monophosphat.