title: Extracellular microtubule-like structures in the retina of the rainbow trout: development, intercellular connectivity and reaction to vincristine.
abstract: Extracellular microtubule-like structures (MLS) are described in the retina of the rainbow trout. They appear about 30 to 40 days after hatching, when the yolk-sac is consumed and the animal begins to swim and to nourish actively. They fill a widely branched system of extracellular clefts and spaces, and connect different cells and cell types, especially outer horizontal cells and bipolar cells. The MLS are not affected by the vinca alcaloid vincristine, although this drug penetrates into the MLS-filled space, as has been shown by the formation of intracellular, vincristine-induced tubulin paracrystals. The MLS are compared with other extracellular tubular structures described in other animal tissues. Their functional significance remains unclear.
mesh_terms: D000367:Age Factors; D000818:Animals; D005110:Extracellular Space; D008854:Microscopy, Electron; D008870:Microtubules / Q000187:drug effects / Q000648:ultrastructure*; D012160:Retina / Q000187:drug effects / Q000254:growth & development / Q000648:ultrastructure*; D012487:Salmonidae / Q000033:anatomy & histology*; D014337:Trout / Q000033:anatomy & histology* / Q000254:growth & development; D014750:Vincristine / Q000494:pharmacology*
chemical_list: D014750:Vincristine