title: [Harmlessness of plumbagine in a biological experiment].
abstract: Plumbagine (2-methyl-5-oxy-1,4-naphtoquinone) did not have any essential effect on the general condition and dynamic changes in the body mass of albino rats, their blood coagulation system and fibrinolysis, the liver and renal functions and morphological structure of the internal organs. An analysis of the available data justify recommending plumbagine as a preservative of soft, when used in doses not exceeding 0.8--1.0 mg/l, i.e. 0.00008--0.0001 per cent of the finished product mass.
mesh_terms: D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation / Q000187:drug effects; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects; D005520:Food Preservatives; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008297:Male; D009285:Naphthoquinones / Q000633:toxicity*; D051381:Rats; D013997:Time Factors
chemical_list: D005520:Food Preservatives; D009285:Naphthoquinones
vernacular_title: Izuchenie bezvrednosti plombagina v biologicheskom éksperimente.