Funiculosin, a new antibiotic. II. Structure elucidation and antifungal activity.
Structure elucidation and some biological properties of an antiviral and antifungal antibiotic, funiculosin, are summarized. Funiculosin is a derivative of N-methyl-4-hydroxy-3, 5-disubstituted-2-pyridone containing a novel substituent, cyclopentanetetrol moiety, that is reported here for the first time in a natural product. The antibiotic protects guinea pigs efficiently against experimental trichophytosis. Toxicity of funiculosin is unique and highly selective for animal species.
D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D055598:Chemical Phenomena; D002621:Chemistry; D006168:Guinea Pigs; D007928:Lethal Dose 50; D051379:Mice; D008958:Models, Molecular; D011728:Pyridones / Q000494:pharmacology* / Q000627:therapeutic use; D011817:Rabbits; D051381:Rats; D014005:Tinea / Q000517:prevention & control
D000935:Antifungal Agents; D011728:Pyridones