Possible tumor localization of Tc-99m-labeled liposomes: effects of lipid composition, charge, and liposome size.
The possible in vivo distribution of liposomes after they have been directly labeled with Tc-99m has been studied in rats bearing the Walker 256 carcinoma. The importance of lipid composition, charge, and size of liposome were studied with respect to possible tumor-localizing properties. Tumor uptake was best with small, fluid-membrane, negatively charged liposomes, as indicated by the distribution of the Tc-99m label. The uptake was visualized on scintigrams.
D000588:Amines; D000818:Animals; D002279:Carcinoma 256, Walker / Q000175:diagnosis* / Q000378:metabolism; D002784:Cholesterol; D008081:Liposomes / Q000378:metabolism; D010712:Phosphatidic Acids; D010713:Phosphatidylcholines; D051381:Rats; D013667:Technetium / Q000378:metabolism
D000588:Amines; D008081:Liposomes; D010712:Phosphatidic Acids; D010713:Phosphatidylcholines; D013667:Technetium; D002784:Cholesterol