Protection of mice against tick-borne encephalitis by different classes of immunoglobulins.
The protective capacities of IgM and IgG immunoglobulins from fractionated human or mouse sera were investigated in tests with tick-borne encephalitis virus. Mice were resistant to challenge with tick-borne encephalitis virus if previously inoculated with specific immunoglobulins but not nonspecific immunoglobulins. The protective ability of IgM, whether derived from mouse or human sera, was only about 1/40 of that of IgG preparations adjusted to the same haemagglutination inhibition or neutralising titres.
D000818:Animals; D000918:Antibody Specificity; D004675:Encephalitis, Tick-Borne / Q000517:prevention & control*; D006801:Humans; D007106:Immune Sera; D007074:Immunoglobulin G / Q000627:therapeutic use; D007075:Immunoglobulin M / Q000627:therapeutic use; D007136:Immunoglobulins / Q000627:therapeutic use*; D051379:Mice
D007106:Immune Sera; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins