Effect of acute and chronic administration of 5-FU on pancreatic secretion.
The administration of various dose schedules of 5-FU did not result in any alteration of pancreatic secretion. The findings would not support the thesis that the gastrointestinal side-effects of this potent cancer chemotherapeutic agent are the result of a toxic pancreatic insufficiency.
D000818:Animals; D001639:Bicarbonates / Q000378:metabolism; D002766:Cholecystokinin / Q000494:pharmacology; D004285:Dogs; D005472:Fluorouracil / Q000008:administration & dosage / Q000494:pharmacology*; D010179:Pancreas / Q000378:metabolism*; D010189:Pancreatic Juice / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D012633:Secretin / Q000494:pharmacology
D001639:Bicarbonates; D011506:Proteins; D012633:Secretin; D002766:Cholecystokinin; D005472:Fluorouracil