The effect of neonatal oil administration on brain weight of inbred and heterogeneous mice.
A single injection of sesame oil on postnatal Day 4 reduced adult bain weight in male and female mice of the C3H/HeJ strain. The same neonatal treatment had no effect on brain weight of heterogeneous mice derived from a cross of 8 inbred strains. In agreement with previous findings in inbred strains, C3H/HeJ females were found to have larger brains than males. This difference between the genders was not seen in heterogeneous mice. The effect of neonatal oil administration on adult brain weight provides an additional example of the effect of neonatal manipulations on the adult organism and underscores the importance of adherence to appropriate control procedures in studies involving administration of hormones in early life, particularly when infant strains are used  as experimental subjects.
D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000254:growth & development*; D005260:Female; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008815:Mice, Inbred Strains; D009821:Oils / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D012715:Sesame Oil / Q000494:pharmacology; D012737:Sex Factors; D013739:Testosterone / Q000494:pharmacology
D009821:Oils; D013739:Testosterone; D012715:Sesame Oil