Use of propanidid and lignocaine to modify the increase in serum potassium concentration following injection of suxamethonium.
A technique of general anaesthesia involving the use of propanidid, nitrous oxide, oxygen and halothane followed by a slow injection of suxamethonium and lignocaine is described. The technique decreased the increase in serum potassium concentration that follows the injection of suxamethonium and, it is suggested, possesses advantages over the existing practice of the injection of non-depolarizing neuromuscular blocking drugs before suxamethonium in an attempt to reduce the frequency of serious cardiac arrhythmia.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000768:Anesthesia, General / Q000379:methods*; D002648:Child; D005260:Female; D006221:Halothane; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D009609:Nitrous Oxide; D010100:Oxygen; D011188:Potassium / Q000097:blood*; D011410:Propanidid / Q000008:administration & dosage / Q000494:pharmacology; D013390:Succinylcholine / Q000494:pharmacology*
D008012:Lidocaine; D011410:Propanidid; D013390:Succinylcholine; D009609:Nitrous Oxide; D011188:Potassium; D010100:Oxygen; D006221:Halothane