title: The influence of zinc-deprivation on the mast cell population of the bone marrow and other tissues.
abstract: Five groups consisting of 72 young male Sprague-Dawley rats were submitted to dietary Zn deprivation (1 ppm versus 50 ppm for controls) for periods of 1 to 6 weeks with ad libitum or pair feeding. After 1 week of Zn deficiency, growth was almost arrested, the oesophageal epithelium became hyperplastic. After 3 weeks, the mast cell population of the bone marrow increased rapidly in ad libitum fed and also in pair-fed rats. Between 3 and 5 weeks, the thickness of the proximal epiphyseal plate of the tibia decreased by 33%. Contrary to Mg-deficient rats, Zn-deprived rats maintained their skin and thyroid mast cell populations after 5 weeks. The mast cell population of the metaphysis of the tibia increased from 1 to 5 weeks in both Zn-deficient and Zn-supplemented rats. In the Zn-deprived rats however, the mast cell population became increasingly higher than in the Zn-supplemented, from 1 to 5 weeks. In the pair-fed group, the mast cell population of the marrow was also significantly higher after 3 weeks. The special response of the bone marrow cells to Zn-depletion points to this tissue as a renewal site. Zinc may also be a maturation factor for mast cells.
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells; D002452:Cell Count; D004848:Epithelium / Q000473:pathology; D004947:Esophagus / Q000473:pathology; D006965:Hyperplasia; D008297:Male; D008407:Mast Cells / Q000166:cytology*; D051381:Rats; D012867:Skin / Q000166:cytology*; D013961:Thyroid Gland / Q000166:cytology*; D013977:Tibia; D015032:Zinc / Q000008:administration & dosage / Q000172:deficiency* / Q000627:therapeutic use
chemical_list: D015032:Zinc