Irradiation of mice pre-treated with radiation protective substances. A pathologic and haematologic investigation.
CBA male mice were irradiated with single doses of 7.1, 8.6, 10.0, 11.4 or 12.8 Gy, respectively. A protective substance, 2,2-Dithiobis(N-[(1-adamantyl)methyl]acetamidine)-dihydrochloride, here called S-75, was administered orally, 45 min before start of irradiation. Cysteamine-HCl was used as a reference protective substance. Pathologic and haematologic examination of irradiated animals was performed. Cysteamine had somewhat better protective abilities than did S-75, but the latter had some other properties which indicate its possible usefulness in practice.
D000081:Acetamides / Q000627:therapeutic use*; D000218:Adamantane / Q000031:analogs & derivatives / Q000627:therapeutic use*; D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000528:radiation effects; D001952:Bridged-Ring Compounds / Q000627:therapeutic use*; D003543:Cysteamine / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D006470:Hemorrhage / Q000209:etiology / Q000517:prevention & control*; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009929:Organ Size / Q000528:radiation effects; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D013853:Thioacetamide / Q000031:analogs & derivatives / Q000627:therapeutic use*
D000081:Acetamides; D001952:Bridged-Ring Compounds; D011837:Radiation-Protective Agents; D013853:Thioacetamide; D003543:Cysteamine; D000218:Adamantane