[Cefamandol: pharmacokinetics with normal and impaired renal function (author's transl)].
1.0 g cefamandol was injected in 25 patients with various degrees of renal function. Half-life and distribution volume of this antibiotic and the glomerular filtration rate (GFR) were then measured. The distribution volume was 18.5 +/- 3.5% of body weight, similar to the extracellular space. Half-life and GFR were related in a way which could be expressed in the formula: half-life = 400 sqaure root GFR. Levels of blood concentration of cefamandol could be estimated from half-life and GFR, with the construction of "isoconcentration dosages", by which it is possible to achieve levels similar to those in normal subjects receiving a normal dosage.
D001835:Body Weight; D002435:Cefamandole / Q000008:administration & dosage / Q000032:analysis / Q000378:metabolism*; D002511:Cephalosporins / Q000378:metabolism*; D005110:Extracellular Space; D005260:Female; D005919:Glomerular Filtration Rate; D006207:Half-Life; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism*; D007700:Kinetics; D008297:Male
D002511:Cephalosporins; D002435:Cefamandole
Cefamandol: Pharmakokinetik bei normaler und eingeschränkter Nierenfunktion.