Acute acetaminophen intoxication.
Acetaminophen is a readily available, widely used drug which has been thought safer than aspirin. Overdosage which may result in fatal hepatic necrosis is commonly seen in the United Kingdom but is rarely reported in the United States. In a two-month period, three patients were admitted to a general hospital because of acetaminophen overdose, suggesting that this problem may occur more commonly than expected. They were successfully treated with N-acetylcysteine. Our experience in management of these three patients is presented and the pertinent literature concerning diagnosis and treatment of acute acetaminophen intoxication in briefly reviewed.
D000082:Acetaminophen / Q000506:poisoning*; D000111:Acetylcysteine / Q000627:therapeutic use; D000328:Adult; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D003543:Cysteamine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects; D008297:Male; D008715:Methionine / Q000627:therapeutic use; D013406:Suicide, Attempted
D000082:Acetaminophen; D003543:Cysteamine; D008715:Methionine; D000111:Acetylcysteine