[Effect of serum of different origin on elaboration of interferon and the activity of the lysosomal apparatus of cells from the abdominal exudate of newborn mice].
In the presence of serum from newborn mice the cells of newborn mice produce almost no interferon induced by Newcastle disease virus. When cultivated in a medium containing adult mouse serum, interferon production by the cells increases markedly reaching the level of interferon production by the cells of adult animals. It is suggested that there are factors present in mouse serum which are capable, depending on the age of the animals, either of inhibiting or stimulating the activation of lysosomal apparatus and interferon production.
D000135:Acid Phosphatase / Q000378:metabolism; D000367:Age Factors; D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology*; D007106:Immune Sera / Q000494:pharmacology*; D007369:Interferon Inducers / Q000032:analysis*; D007372:Interferons / Q000096:biosynthesis*; D008247:Lysosomes / Q000378:metabolism*; D051379:Mice; D009522:Newcastle disease virus; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis
D007106:Immune Sera; D007369:Interferon Inducers; D012313:RNA; D007372:Interferons; D000135:Acid Phosphatase
Vliianie syvorotki razlichnogo proiskhozdeniia na vyrabotku interferona i aktivnost' lizosomnogo apparata kletok briushnopolostnogo ékssudata novorozhdennykh myshei.