Modification of ovine fetal respiratory-like activity by chronic diazepam administration.
Chronic maternal administration of diazepam resulted in a modification of fetal respiratory-like activity (FRLA) in the sheep. An over-all increase in this activity occurred. This increase was probably due to a rebound effect following periods of acute suppression with each administration of diazepam. Loss of central control in the regulation of FRLA was implied. A complete reversal of a circadian rhythm of FRLA was observed in animals receiving diazepam. These changes have implications with respect to the antenatal monitoring of the fetus and sequelae in the newborn infant.
D000818:Animals; D002940:Circadian Rhythm / Q000187:drug effects; D003975:Diazepam / Q000494:pharmacology*; D005260:Female; D005333:Fetus / Q000187:drug effects*; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D012119:Respiration / Q000187:drug effects*; D012756:Sheep
D003975:Diazepam