The effect of free fatty acids on myocardial oxygen consumption during atrial pacing and catecholamine infusion in man.
The effect of myocardial uptake of free fatty acids (FFAu) on myocardial oxygen consumption (MVO2) in relation to increased heart rate and inotropic stimulation was determined in patients with coronary artery disease. Submaximal atrial pacing and isoproterenol stimulation increased MVO2 by 66% and 142%, respectively, at similar heart rates. Inhibition of lipolysis with beta-pyridyl carbinol almost abolished FFAu and reduced MVO2 significantly. Increased heart rate contributed 47% and FFAu 50% of the raised MVO2 attributed to inotropic stimulation was 30%. Augmentation of FFAu by triglyceride/heparin infusion increased MVO2 significantly above control levels, both during pacing and isoproterenol infusion. We conclude that MVO2 is closely correlated to FFAu, catecholamines sensitize the heart to FFA, and increased FFAu account for a major part of the increased MVO2 during catecholamine stimulation. The importance of reducing heart rate and lipolysis to reduce myocardial oxygen requirements is emphasized.
D001794:Blood Pressure / Q000187:drug effects; D002304:Cardiac Pacing, Artificial; D002395:Catecholamines / Q000494:pharmacology*; D005230:Fatty Acids, Nonesterified / Q000097:blood / Q000494:pharmacology*; D006325:Heart Atria / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D009206:Myocardium / Q000378:metabolism*; D009540:Nicotinyl Alcohol / Q000627:therapeutic use; D010101:Oxygen Consumption / Q000187:drug effects*; D014280:Triglycerides / Q000627:therapeutic use
D002395:Catecholamines; D005230:Fatty Acids, Nonesterified; D014280:Triglycerides; D006493:Heparin; D009540:Nicotinyl Alcohol