Ultraviolet radiation--induced chromosomal abnormalities in fetal fibroblasts from New Zealand black mice.
Fibroblasts from New Zealand Black mouse fetuses manifest increased frequency of chromosomal breaks and interchanges after exposure to ultraviolet radiation when compared with cells from BABL/c fetuses. This chromosomal instability is similar to what has been reported in cells from patients with xeroderma pigmentosum and may be related to the chromosomally abnormal clones and malignancy previously reported in adult New Zealand Black mice.
D000818:Animals; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000528:radiation effects*; D004195:Disease Models, Animal; D004307:Dose-Response Relationship, Radiation; D051379:Mice; D008807:Mice, Inbred BALB C / Q000502:physiology; D008814:Mice, Inbred NZB / Q000502:physiology*; D014466:Ultraviolet Rays; D014983:Xeroderma Pigmentosum / Q000503:physiopathology