Influence of corticosteroid on hexobarbital and tolbutamide disposition.
The influence of 10 days' prednisone treatment on the disposition of hexobarbital and tolbutamide was studied in 7 healthy male volunteers. No significant changes in the pharmacokinetic parameters of the two drugs became apparent, which indicates that prednisone pretreatment does not affect their metabolic activities.
D000328:Adult; D004347:Drug Interactions; D005938:Glucocorticoids / Q000494:pharmacology*; D006207:Half-Life; D006591:Hexobarbital / Q000097:blood*; D006801:Humans; D007700:Kinetics; D008297:Male; D011241:Prednisone / Q000494:pharmacology; D013997:Time Factors; D014044:Tolbutamide / Q000097:blood*
D005938:Glucocorticoids; D014044:Tolbutamide; D006591:Hexobarbital; D011241:Prednisone