title: Applications of purification reactions for minimizing reaction-generated enzyme poisoning.
abstract: A mathematical model has been employed to examine the interplay of reaction and mass transfer in immobilized enzyme systems involving reaction-generated enzyme poisions. Deactivation rates can be significantly reduced in some cases by catalyzing a purification reaction in which the poison is transformed into an innocuous substance. This conclusion in illustrated experimentally for reaction-generated H2O2 in  a continuous-flow stirred slurry reactor containing glucose oxidase immobilized on activated carbon.
mesh_terms: D004800:Enzymes, Immobilized / Q000037:antagonists & inhibitors* / Q000378:metabolism; D005949:Glucose Oxidase / Q000037:antagonists & inhibitors / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000378:metabolism / Q000494:pharmacology; D007700:Kinetics; D008954:Models, Biological
chemical_list: D004800:Enzymes, Immobilized; D006861:Hydrogen Peroxide; D005949:Glucose Oxidase