Minoxidil treatment of malignant hypertension. Recovery of renal function.
We treated eight severely hypertensive, long-term hemodialysis patients who failed to respond to ultrafiltration or conventional medication with minoxidil rather than with bilateral nephrectomy. Control of blood pressure and relief of symptoms was achieved in all eight. In addition, three of the patients, who were all severely oliguric, recovered sufficient renal function to allow the discontinuation of dialysis. Two are presently doing well, while one died of causes unrelated to uremia or minoxidil therapy. We presently reserve bilateral nephrectomy for those hypertensive dialysis patients who are awaiting transplantation.
D058186:Acute Kidney Injury / Q000628:therapy; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006801:Humans; D006974:Hypertension, Malignant / Q000188:drug therapy*; D007668:Kidney / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D008914:Minoxidil / Q000494:pharmacology / Q000627:therapeutic use*; D009846:Oliguria / Q000628:therapy; D011743:Pyrimidines / Q000627:therapeutic use*; D006435:Renal Dialysis
D011743:Pyrimidines; D008914:Minoxidil