Evidence that inhibition of myometrial activity by oestradiol in the rat is mediated by an RNA synthetic pathway.
Within some 14 h of treatment with oestradiol benzoate (5 microgram), the intra-uterine pressure cycles in ovariectomized puerperal rats were almost abolished. However, treatment with 600 microgram actinomycin D 30 min before the administration of oestradiol benzoate interfered significantly with the inhibition of uterine mechanical activity during the following 14h. Treatment of rats with actinomycin D alone produced no significant fall in the frequency of pressure cycles. These results suggest that oestrogen inhibits myometrial activity in the rat through a mechanism which involves the synthesis of protein.
D000818:Animals; D003609:Dactinomycin / Q000494:pharmacology*; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D008954:Models, Biological; D009215:Myometrium / Q000187:drug effects*; D011247:Pregnancy; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D014599:Uterus / Q000187:drug effects*
D003609:Dactinomycin; D004958:Estradiol; D012313:RNA