title: [Metabolism of nuclear proteins during hormone-dependent cell differentiation in the mammae of goats].
abstract: The metabolism of nuclear proteins was studied at differentiation of mammary cells in the tissue culture with lactogenic hormones. The synthesis of nuclear acidic proteins under the influence of insulin is shown to be an initial step in cell differentiation of the gland; later the DNA synthesis is stimulated, and the synthesis and phosphorylation of histones are intestified. The inducing action of prolactin on the synthesis of RNA and casein is displayed only after the action of insulin and hydrocortisone on the tissue.
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis; D005260:Female; D006657:Histones / Q000378:metabolism; D006854:Hydrocortisone / Q000494:pharmacology*; D007328:Insulin / Q000494:pharmacology*; D008321:Mammary Glands, Animal / Q000166:cytology* / Q000378:metabolism; D009698:Nucleoproteins / Q000378:metabolism*; D009924:Organ Culture Techniques; D010710:Phosphates / Q000378:metabolism; D011388:Prolactin / Q000494:pharmacology*; D012313:RNA / Q000096:biosynthesis
chemical_list: D006657:Histones; D007328:Insulin; D009698:Nucleoproteins; D010710:Phosphates; D012313:RNA; D011388:Prolactin; D004247:DNA; D006854:Hydrocortisone
vernacular_title: Metabolizm iadernykh belkov pri gormonzavisimoĭ differentsirovke kletok molochnoĭ zhelezy koz.