[Recurrent pneumonias following intrauterine irradiation of the thymus (author's transl)].
A 9 year old girl is described who was born without thyroid function as a result of maternal 131I treatment during early pregnancy. The patient had 15 pneumonias since her second year of life. Immunological investigations showed normal humoral immunity and a normal in vitro responsiveness of circulating lymphocytes. The patient was, however, anergic to 5 skintest antigens and exhibited a primary vaccination reaction after a smallpox revaccination. The findings suggest that intrauterine irradiation primarily affected memory-lymphocytes.
D002648:Child; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007457:Iodine Radioisotopes; D011014:Pneumonia / Q000209:etiology* / Q000276:immunology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000532:radiotherapy*; D011832:Radiation Injuries / Q000209:etiology*; D012882:Skin Tests; D012899:Smallpox / Q000517:prevention & control; D013950:Thymus Gland / Q000528:radiation effects*; D013961:Thyroid Gland / Q000002:abnormalities; D013964:Thyroid Neoplasms / Q000532:radiotherapy*; D014611:Vaccination
D007457:Iodine Radioisotopes
Rezidivierende Pneumonien nach intrauteriner Bestrahlung des Thymus.