The accumulation of mono-2-ethylhexylphthalate (MEHP) during storage of whole blood and plasma.
The accumulation of the plasticizer di-2-ethylhexylphthalate (DEHP) in blood and blood components has been of considerable concern for some time. We have followed the accumulation of DEHP and one of its major metabolities, mono-2-ethylhexylphthalate (MEHP) during storage of whole blood, platelet-rich plasma, platelet concentrates, and platelet-poor plasma for periods ranging from 72 hours to four weeks. Both phthalates showed a progressive increase in concentration with time. While the levels of DEHP were much greater than those of MEHP, there was nonetheless a significant and continual increase in MEHP in all preparations. The highest concentrations of both DEHP and MEHP were found in the platelet-poor plasma, indicating that platelets do not have a major role in the accumulation of the phthalates in blood. The accumulation of MEHP was shown to be a direct result of the metabolism of DEHP by plasma protein(s) rather than leaching from the blood bag.
D001792:Blood Platelets / Q000378:metabolism; D001793:Blood Preservation; D004051:Diethylhexyl Phthalate / Q000097:blood*; D010795:Phthalic Acids / Q000097:blood*; D011143:Polyvinyl Chloride / Q000009:adverse effects; D013997:Time Factors
D010795:Phthalic Acids; D011143:Polyvinyl Chloride; D004051:Diethylhexyl Phthalate