Fate of 14C-3-methylamino-1,2,3,4-tetrahydrocarbazole hydrochloride in rats and dogs.
The fate of 14C-3-methylamino-1,2,3,4-tetrahydrocarbazole hydrochloride, a potential psychotherapeutic agent, was studied in rats and dogs. Rats were given a single oral or intraperitoneal dose while dogs received the drug either orally or intravenously. Radioactivity in plasma samples and excreta was determined by liquid scintillation counting. In addition, 14C-levels in various rat tissues were estimated. The drug appeared to be well absorbed in both species. 14C-levels were highest in liver and lung and lowest in plasma. Excretion was primarily urinary and was more complete within the first 96 hr in the rat than in the dog, which suggested a longer 14C-half-life in the dog. No evidence was seen that the drug was demethylated.
D000818:Animals; D002227:Carbazoles / Q000378:metabolism*; D004285:Dogs; D007408:Intestinal Absorption; D007700:Kinetics; D008297:Male; D011619:Psychotropic Drugs / Q000378:metabolism*; D051381:Rats; D014018:Tissue Distribution
D002227:Carbazoles; D011619:Psychotropic Drugs; C018095:3-methylamino-1,2,3,4-tetrahydrocarbazole