title: [Comparative studies on the termination of intact and disturbed pregnancies by intramuscular application of 15(s)-15-methyl-prostaglandin F2alpha (author's transl)].
abstract: 15(S)-15-Methyl-Prostaglandin F2alpha was applied intramuscular to end 27 intact pregnancies mainly in the second trimenon and to induce abortion in 5 cases of disturbed pregnancy. The results showed a similar success of 90 percent in the cases of interruptions compared with the natural prostaglandins applied either extra- or intraamniotic; in the mean induction-abortion-interval of 16 hours the 15(S)-15-Methyl-Prostaglandin F2alpha is better than natural prostaglandins. It is much simpler to apply, the dosage is less. The initial dose is 250 mcg intramuscular, further doses depend on the success achieved, the effect on the bowel activity may be used as indicator. The intramuscular method avoids complications connected with the intraamniotic application, infections of the intracervical catheter lying for a long time and the severe side effects of the intravenous application. In cases of missed abortion and hydatidiform moles, where the use of natural prostaglandins is problematic, the use of 15(S)-15-Methyl-Prostaglandin F2alpha is a progress in this form of therapy.
mesh_terms: D000028:Abortion, Induced; D000030:Abortion, Missed / Q000628:therapy; D000293:Adolescent; D000328:Adult; D005260:Female; D005769:Gastrointestinal Motility; D006801:Humans; D006828:Hydatidiform Mole / Q000628:therapy; D011247:Pregnancy; D011248:Pregnancy Complications; D011262:Pregnancy Trimester, Second; D011461:Prostaglandins F, Synthetic; D013997:Time Factors; D014594:Uterine Neoplasms / Q000628:therapy
chemical_list: D011461:Prostaglandins F, Synthetic
vernacular_title: Vergleichende Untersuchungen über 15(S)-15-Methyl-Prostaglandin F2alpha intramuskulär bei der Beendigung intakter und gastörter Schwangerschaften.