The solubilization of progesterone by mixed bile salt-phospholipid sols.
The solubility of progesterone was determined in several different bile salt-phospholipid mixtures, and it is concluded that: (1) The solubility in unconjugated bile salts is greater than in the conjugated analogues, and the solubility in deoxycholate solutions is twice that in cholate solutions. (2) Substitution of hydroxyl groups in the 11 and 21 positions of progesterone increases solubility, whilst substitution in the 17-position decreases solubility in bile salt solutions. (3) Progesterone solubility in mixed bile salt solutions is proportional to the mole ratio of the surfactant mixture. (4) Sodium deoxycholate (SDC)-phospholipid sols show no such linear solubilizing properties; a minimum occurring at a mole ratio of SDC to phospholipid of 1 : 4. (5) There is a break in the solubility curve of progesterone in lysophosphatidycholine (LPC)/phosphatidylcholine (PC) mixtures at a mole ratio of 65 : 35 coincident with maximum viscosity. (6) Introduction of SDC into LPC/PC mixtures results in decreased progesterone solubility.
D001647:Bile Acids and Salts; D004970:Estrone; D006908:Hydroxyprogesterones; D008244:Lysophosphatidylcholines; D010713:Phosphatidylcholines; D011374:Progesterone; D012995:Solubility
D001647:Bile Acids and Salts; D006908:Hydroxyprogesterones; D008244:Lysophosphatidylcholines; D010713:Phosphatidylcholines; D004970:Estrone; D011374:Progesterone