Carcinogenic activation of benzo(a)pyrene by iodine and ferric chloride in the respiratory tract of Syrian golden hamsters.
Benzo(a)pyrene (0.5 mg), in itself weakly carcinogenic, when given in combination with ferric chloride (0.16 mg) or iodine (0.2 mg), alone noncarcinogen, induced a number of tumors of different parts of the respiratory tract of Syrian golden hamsters.
D000818:Animals; D001580:Benzopyrenes / Q000494:pharmacology*; D006224:Cricetinae; D004357:Drug Synergism; D005290:Ferric Compounds / Q000494:pharmacology*; D007455:Iodine / Q000494:pharmacology*; D007501:Iron / Q000494:pharmacology*; D008647:Mesocricetus; D012142:Respiratory Tract Neoplasms / Q000139:chemically induced*
D001580:Benzopyrenes; D005290:Ferric Compounds; D007455:Iodine; D007501:Iron