Anti-phalloidine and anti-alpha-amanitine action of silybin in comparison with compounds similar to structural parts of silybin.
Silybin significantly antagonises the lethal poisoning of mice with alpha-amanitine or phalloidine. In the same test, taxifolin, coniferyl alcohol, fisetin and (+)-catechin were not effective.
D000438:Alcohols / Q000494:pharmacology; D000546:Amanitins / Q000037:antagonists & inhibitors* / Q000633:toxicity; D000818:Animals; D002392:Catechin / Q000494:pharmacology; D002934:Cinnamates / Q000494:pharmacology; D005260:Female; D005419:Flavonoids / Q000494:pharmacology*; D044948:Flavonols; D008297:Male; D051379:Mice; D009842:Oligopeptides / Q000037:antagonists & inhibitors*; D010590:Phalloidine / Q000037:antagonists & inhibitors*; D010636:Phenols; D011794:Quercetin / Q000031:analogs & derivatives / Q000494:pharmacology; D012838:Silymarin / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000438:Alcohols; D000546:Amanitins; D002934:Cinnamates; D005419:Flavonoids; D044948:Flavonols; D009842:Oligopeptides; D010636:Phenols; D012838:Silymarin; D010590:Phalloidine; D002392:Catechin; D011794:Quercetin; C003377:taxifolin; C010559:coniferyl alcohol; C017875:fisetin