Role of FSH in regulating granulosa cell division and follicular atresia in rats.
The effects of PMSG on the mitotic activity of granulosa cells and atresia of large folicles in 24-day-old rats were examined. The results showed that the labelling index (1) decreased in atretic follicles parallel with a loss of FSH binding, and (2) increased in hypophysectomized rats treated with FSH. It is concluded that FSH stimulates granulosa cell divisions and that atresia may be caused by reduced binding of FSH to the granulosa cells.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism / Q000502:physiology*; D006064:Gonadotropins, Equine / Q000494:pharmacology; D006107:Granulosa Cells / Q000166:cytology* / Q000187:drug effects; D007016:Hypophysectomy; D006080:Ovarian Follicle / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D051381:Rats
D006064:Gonadotropins, Equine; D005640:Follicle Stimulating Hormone