Metabolism of putrescine to 2-pyrrolidone by rat liver slices.
The metabolism of [14C]putrescine was studied in sliced rat liver in vitro. delta1-Pyrroline and gamma-aminobutyric acid, known metabolic products of putrescine, were found in the medium. However, 2-pyrrolidone was the major product of the metabolism of putrescine secreted into the medium. 2-Pyrrolidone was also synthesized from putrescine by spleen and lung, but not by kidney, brain, heart, or muscle. This is the first demonstration of the synthesis of 2-pyrrolidone in a biological system.
D000818:Animals; D002849:Chromatography, Gas; D003460:Crystallization; D005260:Female; D066298:In Vitro Techniques; D007700:Kinetics; D008099:Liver / Q000378:metabolism*; D011700:Putrescine / Q000378:metabolism*; D011760:Pyrrolidinones / Q000378:metabolism*; D051381:Rats
D011760:Pyrrolidinones; D011700:Putrescine