Effect of apomorphine and piribedil on the secretion of thyrotropin and prolactin in patients with primary hypothyroidism.
The administration of apomorphine and piribedil, two dopaminergic agents, significantly reduced thyrotropin (TSH) and prolactin levels in six female patients with primary hypothyroidism. These data provide further evidence for an inhibitory role of dopaminergic stimulation on TSH secretion.
D000328:Adult; D001058:Apomorphine / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000097:blood*; D010879:Piperazines / Q000494:pharmacology*; D010891:Piribedil / Q000494:pharmacology*; D011388:Prolactin / Q000097:blood*; D013972:Thyrotropin / Q000097:blood*
D010879:Piperazines; D011388:Prolactin; D013972:Thyrotropin; D010891:Piribedil; D001058:Apomorphine