Interaction of chlorpromazine with organic solvents and fatty acids as studied by UV-spectrophotometry.
The magnitude of the UV-spectral change of chlorpromazine increases in the presence of increasing concentrations of alcohols or fatty acids and with increasing chain length. A maximum is reached with 14.0- or 16.0-fatty acids. The differential spectrum is still larger with unsaturated fatty acids, a maximum effect being obtained with one cis-double bond. The spectral change is abolished by chaotropic and enhanced by antichaotropic agents.
D000438:Alcohols; D002746:Chlorpromazine / Q000378:metabolism; D005227:Fatty Acids; D012997:Solvents; D013056:Spectrophotometry, Ultraviolet
D000438:Alcohols; D005227:Fatty Acids; D012997:Solvents; D002746:Chlorpromazine