[Bile acids in the intestinal juice of infants and children with malabsorption and maldigestion syndromes].
43 gastroenterologically healthy infants and children as well as 45 patients with different malabsorption and maldigestion syndromes were investigated during the basic secretion and after injection of secretin and pancreozymin in order to establish the total quantity and also the distribution of the secreted bile acids. The total concentration and quantity were determined enzymatically; column and thinlayer chromatography were utilized to separate the bile into 30 different bile acids. While the total quantity of bile acids was found to be independent of age, the compounding of bile changed during the first years of life. Patients with coeliac disease reacted to injection of peptide hormones by producing a larger volume of secretion than did the control group. Despite the increased secretion there was at the same time a significantly higher concentration of bile acids in the duodenal juice. In this group the analysis of the bile acid distribution indicated no abnormality but striking changes were found in patients with cystic fibrosis, biliary atresia, M. Wilson, and in children after subtotal resection of the small bowel.
D001647:Bile Acids and Salts / Q000032:analysis*; D001660:Biliary Tract Diseases / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D003093:Colitis, Ulcerative / Q000378:metabolism; D003550:Cystic Fibrosis / Q000378:metabolism; D005767:Gastrointestinal Diseases / Q000378:metabolism*; D006527:Hepatolenticular Degeneration / Q000378:metabolism; D006801:Humans; D007223:Infant; D007408:Intestinal Absorption; D007419:Intestinal Secretions / Q000032:analysis*; D007421:Intestine, Small / Q000601:surgery; D008286:Malabsorption Syndromes / Q000378:metabolism*; D010182:Pancreatic Diseases / Q000378:metabolism
D001647:Bile Acids and Salts
Gallensäuren im Darmsaft bei Säuglingen und Kindern mit Malabsorptions- und Maldigestionssyndromen.