[Effect of several extreme influences on the submicroscopic organization of rat liver following carbon tetrachloride poisoning].
Submicroscopic structure of parenchymatous cells was investigated in the liver of rats given CCL4 (0.12 ml/100 g body wt) for 25 days. After cessation of this treatment the animals were subjected to the action of extreme stimulants (immobilization or overheating under sunlight or both). CCL4 poisoning led to the appearance of many lipid incorporations in the cytoplasm of hepatocytes serving as the basis for fat infiltration in the liver. The action of extreme factors was followed by accumulation of lipids in the lumina of the granular cytoplasmic reticulum never found in any other pathological conditions, and apparently reflecting profound disturbances of intracellular metabolism.
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000150:complications* / Q000473:pathology; D056486:Chemical and Drug Induced Liver Injury / Q000150:complications* / Q000473:pathology; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D050356:Lipid Metabolism; D008099:Liver / Q000648:ultrastructure*; D008297:Male; D008854:Microscopy, Electron; D008930:Mitochondria, Liver / Q000648:ultrastructure; D051381:Rats; D012149:Restraint, Physical / Q000009:adverse effects; D013312:Stress, Physiological / Q000150:complications* / Q000473:pathology
Vliianie nekotorykh ékstremal'nykh vozdeĭstvii na submikroskopicheskuiu organizatsiiu pecheni krys pri otravlenii chetyrekhkhloristym uglerodom.