Pharmacokinetics of drug permeation through human skin.
Based on sorption and permeation characteristics of scopolamine in human skin in vitro and drug elimination kinetics obtained from pharmacokinetic studies, a mathematical model was developed for estimating and optimizing the temporal pattern of scopolamine delivery from a transdermal therapeutic system through human skin in vivo. Experimentally measured scopolamine delivery in vivo conformed to this model.
D000284:Administration, Oral; D006801:Humans; D066298:In Vitro Techniques; D007263:Infusions, Parenteral; D007700:Kinetics; D008954:Models, Biological; D010539:Permeability; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D012869:Skin Absorption
D004364:Pharmaceutical Preparations