[Effect of ouabain on an SPEV culture].
The presence of ouabain at a concentration of 4.10(-4) M in the culture medium is shown to lead to cytophysiological and morphological alterations in the cells. The synthetic and mitotic activity of the cells is reduced after 6 hrs of the experiment. The ultrastructure of all cell organelles changed simultaneously with their metabolic activity. The dynamics of ultrastructural alterations of the cells was observed. However, changes caused by ouabain did not result in death of the cell.
D000135:Acid Phosphatase / Q000378:metabolism; D002460:Cell Line; D002467:Cell Nucleus / Q000187:drug effects; D002843:Chromatin / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis; D006056:Golgi Apparatus / Q000187:drug effects; D007930:Leucine / Q000378:metabolism; D008660:Metabolism / Q000187:drug effects*; D008938:Mitosis / Q000187:drug effects*; D009940:Organoids / Q000187:drug effects*; D010042:Ouabain / Q000494:pharmacology*; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis; D013385:Succinate Dehydrogenase / Q000037:antagonists & inhibitors; D013936:Thymidine / Q000378:metabolism; D014529:Uridine / Q000378:metabolism
D002843:Chromatin; D010042:Ouabain; D012313:RNA; D004247:DNA; D013385:Succinate Dehydrogenase; D000135:Acid Phosphatase; D007930:Leucine; D013936:Thymidine; D014529:Uridine
Deĭstvie oubaina na kletki kul'tury SPEV.