Comparative study of the vasoconstrictor activity of halopredone acetate in a modified McKenzie test.
The vasoconstrictor activity of four steroids, administered in solution and in the commercially available form, were compared in healthy volunteer subjects. Evaluation was based on conventional visual observations and photometric measurement of reflectance. Statistical analysis showed that halopredone acetate had less vasoconstrictor action on healthy skin than fluocinolone acetonide, beta-methasone valerate and hydrocortisone acetate. The halopredone acetate results were identical to those of th excipient, although it was found that halopredone acetate cream (Topicon) had a marked anti-inflammatory effect in animals and on human dermatoses. The validity of the McKenzie test, as an unequivocal screening procedure for the potency of topical steroids is discussed, and the accuracy and precision of photometric evaluation is emphasized.
D000287:Administration, Topical; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001624:Betamethasone Valerate / Q000494:pharmacology; D003116:Color; D005446:Fluocinolone Acetonide / Q000494:pharmacology; D005477:Fluprednisolone / Q000031:analogs & derivatives* / Q000494:pharmacology; D005938:Glucocorticoids; D006801:Humans; D006854:Hydrocortisone; D012039:Regional Blood Flow / Q000187:drug effects; D012867:Skin / Q000098:blood supply / Q000187:drug effects; D013997:Time Factors; D014662:Vasoconstrictor Agents
D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D014662:Vasoconstrictor Agents; D005446:Fluocinolone Acetonide; D005477:Fluprednisolone; D001624:Betamethasone Valerate; D006854:Hydrocortisone