[Effect of echinopsin and adepren on motor activity in rats].
We have studied the influence of synthesized in NIHFI psychotropic drugs echinopsin and adepren for their locomotor activity on white rats in open field and staircase. Comparative parallel experiments were carried out with psychostimulants and antidepressive drugs utilized in therapeutic practice. We found that echinopsin in low doses increases the locomotor activity and in large doses decreases. Its action in open-field and staircase is different from the effect of amphetamine and coffeine which is confirmed by clinical evidence. Adepren decreases the locomotor activity in single application as a result of decreasing of brain noradrenaline which is similar to the effect of MAOI drugs.
D000634:Aminoquinolines / Q000494:pharmacology*; D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D000928:Antidepressive Agents; D002110:Caffeine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D007099:Imipramine / Q000494:pharmacology; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D009526:Nialamide / Q000494:pharmacology; D011804:Quinolines / Q000494:pharmacology*; D051381:Rats
D000634:Aminoquinolines; D000928:Antidepressive Agents; D011804:Quinolines; D002110:Caffeine; C012169:adepren; D000661:Amphetamine; D007099:Imipramine; D009526:Nialamide
Vliianie na ekhinopsina i adeprena vurkhu dvigatelnata aktivnost na plukhove.