[The influence of metabolic control on chemotactic activity in insulin-dependent diabetes mellitus (author's transl)].
An increased incidence of infections, especially during periods of poor metabolic control is well known in patients with insulin-dependent diabetes mellitus. Therefore, we studied polymorphonuclear chemotaxis and its dependence on the degree of diabetic control in 49 patients with insulin-dependent diabetes mellitus in 46 controls. A modification of the chemotaxis assay described by Frei et al. was used as test system. The mean chemotactic activity observed in the total group of insulin-dependent diabetics did not differ from the values obtained in the controls. However, in patients with poor diabetic control and glucosuria exceeding 60 g/24h, a significantly reduced chemotactic leucoyte migration was found. These data indicate that normalization of leucotaxis can be achieved in insulin-dependent diabetes by means of adequate diabetes control.
D000328:Adult; D001424:Bacterial Infections / Q000209:etiology; D002633:Chemotaxis; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000276:immunology*; D006029:Glycosuria / Q000276:immunology*; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D014777:Virus Diseases / Q000209:etiology
D007328:Insulin
Der Einfluss der Stoffwechsellage auf die chemotaktische Aktivität beim insulinabhängigen Diabetes mellitus.