Antagonism of neuromuscular block by physostigmine in man.
In 20 adult patients undergoing inguinal herniorrhaphy neuromuscular block was induced with tubocurarine 10 mg. In 10 patients, neostigmine 1--2 mg antagonized the block and restored the twitch response to its baseline value. Physostigmine, up to 4 mg, did not produce significant antagonism of the neuromuscular block.
D000328:Adult; D006801:Humans; D009388:Neostigmine / Q000494:pharmacology; D009469:Neuromuscular Junction / Q000187:drug effects*; D010830:Physostigmine / Q000494:pharmacology*; D013997:Time Factors; D014403:Tubocurarine / Q000494:pharmacology*
D009388:Neostigmine; D010830:Physostigmine; D014403:Tubocurarine