Gracilis interposition in fistulas following radiotherapy for cervical cancer. A retrospective study.
Irradiation fistulas following treatment for cervical cancer are a great challenge even to a skilled surgeon. Because of ischemia and necrosis around the fistula, repair is possible only by interposition of viable tissue. Interposition of 1 or 2 mm gracilis has been used at Sabbatsberg Hospital since the beginning of the 1950's. 27 vesicovaginal fistulas have been treated with this method, with a cure rate of 60%. The corresponding cure rate for 16 rectovaginal fistulas was 43%. The mean diameter of the fistulas was 2.5 cm. Considering the unfavorable circumstances caused by radiotherapy, in some cases combined with fulguration, these results seem satisfactory.
D000328:Adult; D001189:Aryl Hydrocarbon Hydroxylases; D000072467:Cytochrome P450 Family 2; D005260:Female; D006801:Humans; D009132:Muscles / Q000601:surgery; D011878:Radiotherapy / Q000009:adverse effects; D012006:Rectovaginal Fistula / Q000209:etiology / Q000601:surgery; D012189:Retrospective Studies; D013250:Steroid Hydroxylases; D002583:Uterine Cervical Neoplasms / Q000532:radiotherapy*; D014719:Vesicovaginal Fistula / Q000209:etiology / Q000601:surgery*
D013250:Steroid Hydroxylases; D001189:Aryl Hydrocarbon Hydroxylases; C460223:Cyp2a4 protein, mouse; D000072467:Cytochrome P450 Family 2