title: [DNA replication in HeLa cells after gamma irradiation. I. The period of DNA replicative synthesis after the irradiation of cells in the G1 phase with gamma rays in large doses].
abstract: HeLa G-63 cells irradiated by 5 krads of 60 Co-gamma-rays during their G1-period pass through the S-period of the same interphase just as do non-irradiated cells: the kinetics of labeled cells upon a 30 min incubation with 3H-TdR (radioautography) is the same for both irradiated and non-irradiated cell populations; the rate of 3H-thymidine incorporation during the S-period upon a 3H-TdR continuous incubation is the same for both the cell populations; the mean DNA content per nucleus of irradiated cell is doubled after the S-period (cytophotometry). With increasing the radiation dose (from 10 to 30 krads), the rate of 3H-TdR incorporation into cells falls, and the S-period is prolonged.
mesh_terms: D002453:Cell Cycle / Q000528:radiation effects*; D004247:DNA / Q000096:biosynthesis; D004261:DNA Replication / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D006367:HeLa Cells / Q000528:radiation effects*; D007399:Interphase / Q000528:radiation effects*; D007700:Kinetics; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors
chemical_list: D004247:DNA; D013936:Thymidine
vernacular_title: Replikatsiia DNK v kletkakh HeLa posle gamma-oblucheniia. I. Period replikativnogo sinteza DNK posle oblucheniia kletok v faze G1 gamma-luchami v bol'shikh dozakh.