Plasmapheresis and plasma cholinesterase.
Plasma cholinesterase (E.C. 3.1.1.8) concentrations were measured in nine outpatients who were undergoing regular plasmapheresis. A single plasmapheresis produced a 64% reduction in cholinesterase concentration compared with the value before plasmaphersis. Another patient who received four plasma exchanges in 6 days showed a progressive reduction in cholinesterase concentration to only 8% of the initial value. It is suggested that drugs metabolized by cholinesterase should be used with caution in patients undergoing plasmapheresis, particularly when frequent plasma exchanges are undertaken.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002802:Cholinesterases / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D010956:Plasmapheresis; D013997:Time Factors
D002802:Cholinesterases