The identification of trihydroxyeicosatrienoic acids as products from the incubation of arachidonic acid with washed blood platelets.
Arachidonic acid is converted by washed platelets from man, horse and dog into a mixture of 8,9,12-trihydroxyeicosa-5,10,14-trienoic acid and 8,11,12-trihydroxyeicosa-5,9,14-trienoic acid (termed 8,9,12-THETA and 8,11,12-THETA respectively and THETA collectively). Gas chromatographic--mass spectrometric evidence of structure is discussed.
D000818:Animals; D001095:Arachidonic Acids / Q000032:analysis / Q000097:blood / Q000378:metabolism*; D001792:Blood Platelets / Q000378:metabolism*; D055598:Chemical Phenomena; D002621:Chemistry; D002849:Chromatography, Gas; D004285:Dogs; D006736:Horses; D006801:Humans; D013058:Mass Spectrometry
D001095:Arachidonic Acids