title: Increased blood pressure in the SHR is not related to a deficit in renomedullary PGE2.
abstract: Synthesis of prostaglandin E2 by renal medulla from SHR and WKY rats was compared during early postnatal development. Although arterial blood pressure was significantly higher in SHR as early as 6 weeks of age, no difference in renal medullary prostaglandin synthesis was observed.
mesh_terms: D000367:Age Factors; D000818:Animals; D001794:Blood Pressure; D006973:Hypertension / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D007679:Kidney Medulla / Q000378:metabolism*; D011458:Prostaglandins E / Q000096:biosynthesis / Q000172:deficiency*; D051381:Rats
chemical_list: D011458:Prostaglandins E