Chronic chlordiazepoxide and pentobarbital interactions on punished and unpunished behavior.
Dose-effect curves were determined in rats for the effects of drugs on punished and unpunished responding maintained by fixed-interval schedules of food presentation before, during and after the drinking of large daily doses of chlordiazepoxide and pentobarbital. An average intake of 50 mg/kg/day of chlordiazepoxide produced tolerance to the rate-decreasing effects of chlordiazepoxide on unpunished responding and cross-tolerance to the rate-decreasing effects of pentobarbital. During chlordiazepoxide drinking, rate-increasing effects of both chlordiazepoxide and pentobarbital on punished responding became apparent. There was no evidence for cross-tolerance between chlordiazepoxide and chlorpromazine. An average intake of 100 mg/kg/day of pentobarbital produced similar evidence of tolerance to the rate-decreasing effects of pentobarbital on unpunished responding and cross-tolerance to the rate-decreasing effects of chlordiazepoxide. Removal of chlordiazepoxide from the drinking water temporarily increased unpunished responding; however, 6 weeks after withdrawal of chlordiazepoxide or pentobarbital from the drinking water, the dose-effect curves for injections of these drugs appeared to be returning to their original positions.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002707:Chlordiazepoxide / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004361:Drug Tolerance; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology*; D011678:Punishment; D051381:Rats; D012055:Reinforcement Schedule
D002707:Chlordiazepoxide; D010424:Pentobarbital