title: [Pharmacology of calenduloside B, a new triterpene glycoside from the roots of Calendula officinalis].
abstract: Calendulozide B--trioside of oleanolic acid, isolated from rhizomes of Calendula officinalis, Fam. Compositae, used perorally in doses of 5, 10, 20 and 50 mg/kg exerted an antiulcerous action in 3 experimental ulcer models of different genesis (caffein-arsenic, butadion and induced by ligation of pylorus) and also displayed a certain antiphlogistic and sedative action. It did not have any effect on the cardiovascular system, the tone of intestinal smooth muscles, diuretic renal function and electrolytes excretion with urine or on the biligenic function of the liver. The drug is devoid of locally irritation properties, manifests a relatively low hemolytic activity (15000 after Kofler) and an insignificant toxicity both with its one-time and chronic administration.
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents; D002415:Cats; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D006027:Glycosides / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D006168:Guinea Pigs; D051379:Mice; D009828:Oleanolic Acid / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D010946:Plants, Medicinal; D011817:Rabbits; D051381:Rats; D012502:Sapogenins / Q000494:pharmacology*; D012503:Saponins / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D013276:Stomach Ulcer / Q000188:drug therapy; D013997:Time Factors
chemical_list: D000893:Anti-Inflammatory Agents; D006027:Glycosides; D012502:Sapogenins; D012503:Saponins; C017833:calendulozide B; D009828:Oleanolic Acid
vernacular_title: K farmakologii kalendulozidaB--novogo triterpenovogo glikozida iz korneĭ kalunduly lekarstvennoĭ.