Testosterone metabolism in basal cell epitheliomas.
In basal cell epitheliomas the testosterone metabolism pattern differs from that of the normal surrounding skin. There is a significant reduction in 5 alpha-reductase activity with a consequent decrease in production of dihydrotestosterone and androstanediols. By contrast the 17 beta-hydroxysteroid dehydrogenase activity shows no consistent change.
D000368:Aged; D015113:Androstane-3,17-diol / Q000378:metabolism; D000734:Androstenediols / Q000378:metabolism; D002280:Basal Cell Carcinoma / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010088:Oxidoreductases / Q000378:metabolism; D012867:Skin / Q000378:metabolism*; D012878:Skin Neoplasms / Q000378:metabolism*; D013739:Testosterone / Q000378:metabolism*
D000734:Androstenediols; D015113:Androstane-3,17-diol; D013739:Testosterone; D010088:Oxidoreductases