title: A proposed mechanism for transient increases in arterial pressure and flow during angiographic injections.
abstract: In a series of animal experiments, we have confirmed the observation that arterial pressure and flow increase distal to the injection site during power injections through non-obstructing catheters. Our data suggest that the phenomenon is secondary to the transient production of turbulence. Thus, for a given injection rate, catheters with smaller end holes create more fluid velocity, which increases the Reynolds number and causes augmentation of downstream pressure and flow. The addition of side holes decreases the fluid velocity of the injectate and minimizes the hemodynamic effects. The discussion deals with factors contributing to the generation of local turbulence, the magnitude of pressure and flow changes caused by the injections, and the clinical implications of these artifacts.
mesh_terms: D000792:Angiography / Q000379:methods*; D000818:Animals; D001783:Blood Flow Velocity; D001794:Blood Pressure; D002404:Catheterization / Q000295:instrumentation*; D003287:Contrast Media / Q000008:administration & dosage; D004285:Dogs; D005263:Femoral Artery; D007275:Injections, Intravenous; D007277:Injections, Jet; D008954:Models, Biological
chemical_list: D003287:Contrast Media