Ophthalmologic toxicity after cis-dichlorodiammineplatinum(II) therapy.
Two cases of apparent ophthalmologic toxicity which occurred during treatment with cis-dichlorodiammineplatinum(II) (DDP) are described. In the first case, a patient with testicular carcinoma developed papilledema after three courses of DDP and adriamycin therapy. In the second case, a patient with breast cancer developed retrobulbar neuritis after three courses of DDP therapy. The differential diagnosis and possible explanation for these toxic effects are discussed.
D000368:Aged; D002945:Cisplatin / Q000009:adverse effects*; D005128:Eye Diseases / Q000139:chemically induced*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009902:Optic Neuritis / Q000139:chemically induced; D010211:Papilledema / Q000139:chemically induced
D002945:Cisplatin