Effect of dose and dose schedule on the response of intracranial pressure to mannitol.
Analysis of monitoring records of 150 patients given over 1000 infusions of 20% mannitol delineared three variables affecting the response of intracranial pressure (ICP) to mannitol: the original ICP; the current dose; and the dose given over the preceding three hours. The level of ICP influenced the response to mannitol as much as the amount of mannitol; giving more mannitol than was required to bring ICP below 25 mm Hg led to the need for larger following doses. One hundred-milliliter-bolus doses were often as effective as larger doses. The results suggest that doses of mannitol given to control increased ICP should be kept as small as possible.
D006801:Humans; D006982:Hypertonic Solutions / Q000008:administration & dosage / Q000494:pharmacology; D007427:Intracranial Pressure / Q000187:drug effects*; D008353:Mannitol / Q000008:administration & dosage* / Q000494:pharmacology
D006982:Hypertonic Solutions; D008353:Mannitol