[Effect of quinolaline di-N-oxide derivatives on the DNAse and plasmocoagulase of Staphylococcus aureus].
The effect of the di-N-oxide quinoxaline on the activity and biosynthesis of DNA-ase and plasmocoagulating properties of the Staphylococcus aureus, strain Zhaev, was studied. The highest action in respect to DNA-ase of the Staphylococcus is shown to display dioxydine (1,4-di-N-oxide of 2,3-dioxymethylquinoxaline). Under its effect there takes place a significant fall of the DNA-ase activity and the plasmocoagulating properties of the staphylococcus. In cultures treated with dioxydine or its biologically active analogues the ability to biosynthetize DNA-ase with subsequent cultivationon on a medium containing no compounds is not restored. A possible mechanism of action produced by the study drugs is suggested.
D003030:Coagulase / Q000096:biosynthesis / Q000378:metabolism*; D003851:Deoxyribonucleases / Q000096:biosynthesis / Q000378:metabolism*; D004789:Enzyme Activation / Q000187:drug effects; D004790:Enzyme Induction / Q000187:drug effects; D011810:Quinoxalines / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000201:enzymology
D003030:Coagulase; D011810:Quinoxalines; D003851:Deoxyribonucleases
Vliianie proizvodnykh di-N-okisi khinoksalina na DNK-azu i plazmokoagulazu zolotistogo stafilokokka.