In vitro growth of ovine squamous cell carcinoma.
Cultured by fragment explantation following a selective trypsinisation procedure, 22/31 (71%) specimens of ovine squamous cell carcinoma yielded pure strains of epithelial cells which to date have passaged vigorously to the 29th level of passage. In contrast to the diploid nature of epithelial cell strains derived from foetal sheep skin, the cell strains derived from skin tumors were highly aneuploid.
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000662:veterinary*; D002478:Cells, Cultured; D004428:Ear Neoplasms / Q000473:pathology / Q000662:veterinary*; D004848:Epithelium / Q000473:pathology; D009669:Nose Neoplasms / Q000473:pathology / Q000662:veterinary*; D012756:Sheep; D012757:Sheep Diseases / Q000473:pathology*