Colonic protection from dimethylhydrazine by a high fiber diet.
Results of this experiment showed that a high fiber bran diet had the ability to lower significantly the incidence of pathologic changes in the colon of mice receiving 1,2-dimethylhydrazine, a drug known for its specificity for causing carcinoma of the colon. This finding adds support to the hypothesis which clains that the addition of bran to the diet has the ability to lower the indicence of carcinoma of the large intestine.
D000236:Adenoma / Q000139:chemically induced / Q000473:pathology; D000818:Animals; D002278:Carcinoma in Situ / Q000139:chemically induced / Q000473:pathology; D002482:Cellulose / Q000627:therapeutic use*; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D004043:Dietary Fiber / Q000627:therapeutic use*; D004127:Dimethylhydrazines / Q000009:adverse effects*; D005260:Female; D008763:Methylhydrazines / Q000009:adverse effects*; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology
D004043:Dietary Fiber; D004127:Dimethylhydrazines; D008763:Methylhydrazines; D002482:Cellulose