Histocompatibility antigens and primary open-angle glaucoma. A reassessment.
Histocompatibility (HLA) antigen typing was performed on 306 patients who had been studied and classified carefully. Black individuals with primary open-angle glaucoma (POAG) had no significant differences in HLA antigen prevalences from black control subjects. In one white population with POAG, a significant decrease in HLA-A1, a significant increase in HLA-Aw31, and a significant increase in the antigen combination HLA-B7 and HLA-Bw22 were noted. However, these differences were not confirmed in a second white population with POAG. We concluded that associations between the A and B loci of the HLA antigen system and POAG were not as impressive as has been previously reported.
D044383:Black People; D005901:Glaucoma / Q000453:epidemiology / Q000235:genetics*; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D008923:Missouri; D044465:White People; D001741:Black or African American
D006680:HLA Antigens