title: [Clinical study of the diuretic preparation moduretic].
abstract: In 75 patients with circulatory insufficiency of various degree the diuretic effect of moduretic was studied. In 25 of them besides the potassium and sodium metabolism and in 33 others, with a background of chronic ischemic disease of the heart and hypertensive disease, the state of the hemocoagulation system was investigated in the moduretic medication. In 24 patients with hypertensive disease of the I--IIA stage subject to study was the effect of moduretic on the arterial pressure, with this drug administered by mouth in doses of 3 to 1/2 tablet a day. The drug proved to have a marked duretic effect in patients with different degree of circulatory insufficiency. It increases sodium excretion with urine and retains potassium in the organism, without causing hyperkaliemia. In patients with circulatory insufficiency of the I degree the drug can provoke thrombogenesis and in cases of the IIA, IIB and III degree may be considered a drug of choice. Moduretic brings down the systolic and diastolic pressure in patients with hypertensive disease of the I and II stages.
mesh_terms: D000328:Adult; D000368:Aged; D000584:Amiloride / Q000008:administration & dosage*; D000925:Anticoagulants; D000959:Antihypertensive Agents; D004232:Diuretics; D004338:Drug Combinations; D005260:Female; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009318:Natriuresis / Q000187:drug effects; D011188:Potassium / Q000378:metabolism; D011719:Pyrazines / Q000008:administration & dosage*
chemical_list: D000925:Anticoagulants; D000959:Antihypertensive Agents; D004232:Diuretics; D004338:Drug Combinations; D011719:Pyrazines; D006852:Hydrochlorothiazide; D000584:Amiloride; D011188:Potassium
vernacular_title: Klinicheskoe izuchenie mochegonnogo preparata moduretika.