[Effect of clonazepam on neuronal activity in the sensomotor cortex of rat brain].
In tests on flaxedyl immobilized rats the effect of clonazepam on the action produced by gamma-aminobutyric acid, acetylcholine and L-glutamate, delivered microionophoretically to neurons of the sensomotor brain cortex, was investigated. Clonazepam was found to potentiate the inhibiting action of gamma-aminobutyric acid and reduce the exciting effect of acetylcholine and L-glutamate on the spontaneous neuronal activity. The ability of clonazepam, like other tranquilizers of the benzodiazepine series, to augment the sensitivity of the receptive neurons formations to gamma-aminobutyric acid and also influence the ionic permeability of the post-synaptic membrane is suggested.
D000109:Acetylcholine / Q000037:antagonists & inhibitors; D000818:Animals; D001570:Benzodiazepinones / Q000494:pharmacology*; D002998:Clonazepam / Q000494:pharmacology*; D004347:Drug Interactions; D018691:Excitatory Amino Acid Antagonists; D009044:Motor Cortex / Q000187:drug effects*; D051381:Rats; D013003:Somatosensory Cortex / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D001570:Benzodiazepinones; D018691:Excitatory Amino Acid Antagonists; D005680:gamma-Aminobutyric Acid; D002998:Clonazepam; D000109:Acetylcholine
O vliianii kolonazepama na neĭronal'nuiu aktivnost' sensomotornoĭ kory golovnogo mozga krys.