Acidic glycosaminoglycans in skin and urine of a patient with wide-spreaded lichen sclerosus et atrophicus.
Changes of dermal and urinary acidic glycosaminoglycans in Lichen Sclerosus et Atrophicus (LSA) were investigated with the following results: 1. Hyaluronic acid (HA) was excreted in urine of a patient with LSA. 2. HA and low sulfate chondroitin were eluted with 0.5 M NaCl by Bio Rad AG 1- X 2 (Cl- form) column chromatography. 3. Involved dermal tissue contained only about 50% of HA in the skin of a healthy adult.
D002807:Chondroitin / Q000378:metabolism; D004588:Electrophoresis, Cellulose Acetate; D006025:Glycosaminoglycans / Q000378:metabolism* / Q000652:urine; D006801:Humans; D006820:Hyaluronic Acid / Q000378:metabolism / Q000652:urine; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000032:analysis*; D012871:Skin Diseases / Q000378:metabolism*
D006025:Glycosaminoglycans; D006820:Hyaluronic Acid; D002807:Chondroitin