title: The effect of an in situ-produced oil shale processing water on metabolism.
abstract: The effects of in situ-produced oil shale retort water on the metabolism of various substrates was studied both in vivo and  in vitro. The induction observed in rats was classified as Type I due to an increase in metabolism of hexobarbital and ethylmorphine without subsequent increases in zoxazolamine metabolism. The maximal absorption of the cytochrome-P450-CO complex was observed to be 450 millimicron, also consistent with Type I inducers. Cytochrome P-450 levels were also significantly increased over controls.
mesh_terms: D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005037:Ethylmorphine-N-Demethylase / Q000378:metabolism; D006207:Half-Life; D006591:Hexobarbital / Q000378:metabolism; D066298:In Vitro Techniques; D007220:Industrial Waste; D008099:Liver / Q000378:metabolism; D008297:Male; D008660:Metabolism / Q000187:drug effects*; D010578:Petroleum; D011506:Proteins / Q000378:metabolism; D051381:Rats; D014873:Water Pollutants / Q000494:pharmacology*; D014874:Water Pollutants, Chemical / Q000494:pharmacology*; D015049:Zoxazolamine / Q000378:metabolism
chemical_list: D007220:Industrial Waste; D010578:Petroleum; D011506:Proteins; D014873:Water Pollutants; D014874:Water Pollutants, Chemical; D003577:Cytochrome P-450 Enzyme System; D015049:Zoxazolamine; D006591:Hexobarbital; D005037:Ethylmorphine-N-Demethylase