Quinazolinylformamidines and quinazolinediylbisformamidines as antihypertensive agents.
Eleven quinazolinylformamidines and quinazolinediylbisformamidines were synthesized and investigated for antihypertensive activity in spontaneous hypertensive rats. Several compounds showed moderate antihypertensive activity at 100 mg/kg po. The same compounds were not hypotensive in the normotensive dog.
D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis*; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D005559:Formamides / Q000138:chemical synthesis* / Q000494:pharmacology; D006973:Hypertension / Q000503:physiopathology; D011799:Quinazolines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats
D000959:Antihypertensive Agents; D005559:Formamides; D011799:Quinazolines