Effect of honey bee venom on prostaglandin levels in mouse skin.
The effects of honey bee venom on prostaglandin (PG) E levels were studied in mouse skin under in vivo and in vitro conditions. Levels of PGE were increased 10.8-fold after 15 minutes exposure to reconstituted bee venom in vitro and 3.8-fold 35 minutes after a bee sting in vivo. Phospholipase A2 (PLA2), a major componet of bee venom, also caused a 10.9-fold increase in PGE levels in vitro and may be primarily responsible for this response of skin to bee venom.
D000818:Animals; D001514:Bee Venoms / Q000494:pharmacology*; D051379:Mice; D010740:Phospholipases / Q000494:pharmacology; D011458:Prostaglandins E / Q000378:metabolism*; D012867:Skin / Q000378:metabolism*
D001514:Bee Venoms; D011458:Prostaglandins E; D010740:Phospholipases