Anticonvulsant activity and monoamine oxidase inhibitory and antihemolytic properties of some newer 4-phenylpiperidino carbamides.
Six 1-[N-acetyl(4-phenylpiperidino)]-3-aryl carbamides were synthesized, characterized and evaluated for their anticonvulsant, monoamine oxidase inhibitory and antihemolytic properties. These compounds (100 mg/kg, i.p.) provided 10--80% protection against pentylenetetrazol-induced seizures in mice. All carbamides (1 mM) inhibited (34--82%) in vitro activity of rat brain monoamine oxidase and provided 18--51% protection against in vitro hypoosmotic hemolysis of human red blood cells at a final concentration of 1 mM. Low toxicity of these carbamides was reflected by their high approximate LD50 values.
D000818:Animals; D000927:Anticonvulsants; D005260:Female; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D008297:Male; D008566:Membranes / Q000187:drug effects; D051379:Mice; D008996:Monoamine Oxidase Inhibitors; D010880:Piperidines / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats
D000927:Anticonvulsants; D008996:Monoamine Oxidase Inhibitors; D010880:Piperidines