Beta blockade and anticonvulsant activity of propranolol.
Racemic and dextro forms of propranolol were equipotent in their anticonvulsant activity in normal rats by the MES test. In an attempt to determine any difference in the anticonvulsant activity of the two forms a variety of adrenergic agents were used, viz. phenoxybenzamine, reserpine, alphamethyl dopa and acetazolamide. There was no difference between the two forms, in the absence or presence of several adrenergic drugs employed. However, racemic but not dextro propranolol reduced MET, in normal as well as in nialamide primed rats.
D000086:Acetazolamide / Q000037:antagonists & inhibitors; D000818:Animals; D000927:Anticonvulsants; D008297:Male; D008750:Methyldopa / Q000494:pharmacology; D010643:Phenoxybenzamine / Q000494:pharmacology; D011433:Propranolol / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats; D012110:Reserpine / Q000494:pharmacology
D000927:Anticonvulsants; D010643:Phenoxybenzamine; D008750:Methyldopa; D012110:Reserpine; D011433:Propranolol; D000086:Acetazolamide