Ocular involvement in hamsters transplanted with a human leukemic T-cell line.
A leukemic T-cell line (TALL-1) was serially transplanted for 5 passages into newborn hamsters treated with antilymphocyte serum. This cell line was derived from a leukemic patient with clinical evidence of ocular involvement. I.p. implantation of 1--3 X 10(7) cells resulted in disseminated growth of tumors in all 15 recipients after 23--41 days and 8 of them showed leukemic infiltration of the uveal tract of one or both eyes.
D000328:Adult; D000818:Animals; D002460:Cell Line; D006224:Cricetinae; D005134:Eye Neoplasms / Q000473:pathology*; D006801:Humans; D007942:Leukemia, Experimental / Q000473:pathology*; D008297:Male; D009361:Neoplasm Invasiveness; D009368:Neoplasm Transplantation; D014603:Uveal Diseases / Q000473:pathology*