Cytophotometric study of the DNA content in experimental pulmonary granuloma.
Pulmonary granulomas were induced in rabbits with Freund's complete adjuvant. Histologic alterations, the mitotic index and Feulgen-DNA amounts determined by a cytophotometric method were studied. The mitotic index and DNA amounts increased significantly within the first hours and reached peak values on the 3rd day, then showed a tendency to decrease after the 7th day. After the 3rd day, a certain dissociation was noted between the mitotic index and Feulgen-DNA amount. The change in Feulgen-DNA content reflects the functional alterations that characterize pulmonary granuloma.
D000818:Animals; D004247:DNA / Q000378:metabolism*; D005620:Freund's Adjuvant; D006099:Granuloma / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D008168:Lung / Q000473:pathology; D008171:Lung Diseases / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D008938:Mitosis; D011817:Rabbits
D004247:DNA; D005620:Freund's Adjuvant