The effect of warfarin and vitamin K-1 on the carboxylation and glycosylation of prothrombin in vivo.
The effect of warfarin and vitamin K-1 on the carboxylation and glycosylation of prothrombin in the rat in vivo was investigated. Neither warfarin nor vitamin K-1 had an effect on carboxylation. However, warfarin inhibited glycosylation 80-90% and this inhibition was readily reversed by the administration of vitamin K-1.
D000818:Animals; D001639:Bicarbonates; D055598:Chemical Phenomena; D002621:Chemistry; D005944:Glucosamine; D008297:Male; D011516:Prothrombin / Q000378:metabolism*; D051381:Rats; D010837:Vitamin K 1 / Q000494:pharmacology*; D014859:Warfarin / Q000494:pharmacology*
D001639:Bicarbonates; D014859:Warfarin; D010837:Vitamin K 1; D011516:Prothrombin; D005944:Glucosamine