Reversibility of hepatitis B virus-induced glomerulonephritis and chronic active hepatitis after spontaneous clearance of serum hepatitis B surface antigen.
A patient presenting with nephrotic syndrome was found to have hepatitis B surface antigen-positive chronic active hepatitis and membranoproliferative glomerulonephritis. Glomeruli stained positive for hepatitis B surface antigen, IgG, and C1q. After spontaneous clearance of hepatitis B surface antigen both the glomerulonephritis and the chronic active hepatitis improved. The natural history, pathogenesis, and treatment of this disease complex are discussed.
D000328:Adult; D001485:Basement Membrane / Q000276:immunology; D002908:Chronic Disease; D003172:Complement C1 / Q000032:analysis; D005921:Glomerulonephritis / Q000150:complications* / Q000276:immunology / Q000473:pathology; D006509:Hepatitis B / Q000150:complications* / Q000276:immunology / Q000473:pathology; D006514:Hepatitis B Surface Antigens / Q000032:analysis*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007668:Kidney / Q000473:pathology; D007678:Kidney Glomerulus / Q000276:immunology; D008099:Liver / Q000473:pathology; D008297:Male
D003172:Complement C1; D006514:Hepatitis B Surface Antigens; D007074:Immunoglobulin G