Increased blood pressure in the SHR is not related to a deficit in renomedullary PGE2.
Synthesis of prostaglandin E2 by renal medulla from SHR and WKY rats was compared during early postnatal development. Although arterial blood pressure was significantly higher in SHR as early as 6 weeks of age, no difference in renal medullary prostaglandin synthesis was observed.
D000367:Age Factors; D000818:Animals; D001794:Blood Pressure; D006973:Hypertension / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D007679:Kidney Medulla / Q000378:metabolism*; D011458:Prostaglandins E / Q000096:biosynthesis / Q000172:deficiency*; D051381:Rats
D011458:Prostaglandins E