Release of VIP, secretin and motilin after duodenal acidification in man.
Plasma VIP, secretin and motilin were measured in 9 volunteers following intraduodenal instillation of 50 ml of 0.1 mol/1 HCl over 3 minutes. VIP rose from 1.7 +/- 0.7 pmol/1 to a peak at 6 minutes of 6.6 +/- 0.9 pmol/1 and was still significantly elevated at 30 minutes. By comparison the elevation of secretin was more transitory rising from a basal value of 2.5 +/- 0.4 pmol/1 to a peak of 10 +/- 1.5 pmol/1 at 3 minutes and returning to baseline by 10 minutes. The rise of motilin, from a higher baseline, was intermediate in pattern, from 23 +/- 7 pmol/1 basally to a 4 minute peak of 40 +/- 10 pmol/1. Thus the elevation of VIP was the most longlasting, and while probably not of sufficient magnitude to stimulate pancreatic bicarbonate secretion via the circulation, could reflect a significant local role in regulating the response of the intestinal mucosa to acid.
D001639:Bicarbonates / Q000378:metabolism; D004386:Duodenum / Q000187:drug effects*; D005768:Gastrointestinal Hormones / Q000378:metabolism*; D006801:Humans; D006851:Hydrochloric Acid / Q000494:pharmacology*; D009037:Motilin / Q000378:metabolism*; D010189:Pancreatic Juice / Q000378:metabolism; D012633:Secretin / Q000378:metabolism*; D014660:Vasoactive Intestinal Peptide / Q000097:blood / Q000378:metabolism*
D001639:Bicarbonates; D005768:Gastrointestinal Hormones; D012633:Secretin; D014660:Vasoactive Intestinal Peptide; D009037:Motilin; D006851:Hydrochloric Acid