Chronic effects of 6-hydroxydopamine and reserpine on myocardial adenylate cyclase.
The effects of chronic administration of 6-hydroxydopamine or reserpine on catecholamine-sensitive adenylate cyclase from rat hearts were studied. Not only basal adenylate cyclase activity, but stimulation of the enzyme by norepinephrine, isoproterenol, NaF, guanylyl-imidodiphosphate, or combination of isoproterenol and guanylyl-imidodiphosphate, was significantly increased in the treated than in the control hearts. It is inferred that supersensitivity of myocardial adenylate cyclase following chronic treatment with reserpine or 6-hydroxydopamine may result from an increase in the catalytic activity of the enzyme.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D004347:Drug Interactions; D005459:Fluorides / Q000494:pharmacology; D006165:Guanylyl Imidodiphosphate / Q000494:pharmacology; D006892:Hydroxydopamines / Q000494:pharmacology*; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009206:Myocardium / Q000201:enzymology*; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D012110:Reserpine / Q000494:pharmacology*; D013997:Time Factors
D006892:Hydroxydopamines; D006165:Guanylyl Imidodiphosphate; D012110:Reserpine; D000262:Adenylyl Cyclases; D007545:Isoproterenol; D005459:Fluorides; D009638:Norepinephrine