title: Method for antibiotic determination in animal tissue, as applied to lasalocid.
abstract: The development of a tissue residue method for an antibiotic is dependent on the history of the overall problem; the current requirements that must be met for regulatory approval; the chemistry of the compound; its physical/chemical parameters; and its microbiological spectrum for the best possible fit of all of these to ensure a procedure that will work reliably in the originator's laboratory and to the same degree of effectiveness in anyone's laboratory. A note is made of those factors that must be included as controls on the procedure and those experiments that must be included to differentiate matrix from method influences.
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis*; D002623:Chemistry Techniques, Analytical / Q000592:standards; D005503:Food Additives / Q000032:analysis*; D007832:Lasalocid / Q000032:analysis*; D008460:Meat / Q000032:analysis*; D008722:Methods; D011200:Poultry; D014018:Tissue Distribution
chemical_list: D000900:Anti-Bacterial Agents; D005503:Food Additives; D007832:Lasalocid