Elastase-inhibitory activity of aortic glycosaminoglycans during cholesterol-induced atherosclerosis.
Elastase-inhibitory activity of aortic glycosaminoglycans, measured in vitro, was found to be significantly reduced in rabbits fed a 2% cholesterol diet for 60, 90, and 120 days. The reduction, suggested to be due to alteration in the composition of aortic glycosaminoglycans, may be relevant to the process of atherogenesis.
D000818:Animals; D001011:Aorta / Q000378:metabolism; D001161:Arteriosclerosis / Q000139:chemically induced / Q000201:enzymology / Q000378:metabolism*; D002791:Cholesterol, Dietary / Q000494:pharmacology*; D006025:Glycosaminoglycans / Q000494:pharmacology*; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors*; D011817:Rabbits; D013997:Time Factors
D002791:Cholesterol, Dietary; D006025:Glycosaminoglycans; D010196:Pancreatic Elastase