[Restoration of glucose utilization in alloxan diabetes by means of inhibiting fatty acid oxidation and gluconeogenesis].
Experiments on intact hungry rats showed hydrazine, gluconeongenesis inhibitor, to cause hypoglycemia; it failed to influence glucose utilization and oxidation, and sharply decreased oleate exidation. Hydrazine inhibition of fatty acids (oleate) oxidation and of gluconeogenesis led to practical normalization of blood glucose level, and also to the utilization and oxidation of glucose in alloxan diabetes. It is postulated that agents with an analogous action mechanism could prove to be effective antidiabetic agents.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000378:metabolism*; D005215:Fasting; D005227:Fatty Acids / Q000037:antagonists & inhibitors*; D005943:Gluconeogenesis / Q000187:drug effects*; D005947:Glucose / Q000378:metabolism*; D006834:Hydrazines / Q000627:therapeutic use; D008297:Male; D009829:Oleic Acids / Q000037:antagonists & inhibitors; D010084:Oxidation-Reduction; D051381:Rats; D013997:Time Factors
D001786:Blood Glucose; D005227:Fatty Acids; D006834:Hydrazines; D009829:Oleic Acids; D005947:Glucose
Vosstanovlenie utilizatsii gliukozy pri alloksanovom diabete putem ingibirovaniia okisleniia zhirkykh kislot i gliukoneogeneza.