Use of adenine nucleotide derivatives to assess the potential of exo-active-site-directed reagents as species- or isozyme-specific enzyme inactivators. 2. Isozyme-specific inactivation of a mammalian enzyme and its significance in the possible design of fetal isozyme targeted antineoplastic agents.
D000227:Adenine Nucleotides / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D005333:Fetus / Q000201:enzymology*; D066298:In Vitro Techniques; D007525:Isoelectric Focusing; D007527:Isoenzymes / Q000037:antagonists & inhibitors*; D007668:Kidney / Q000201:enzymology; D007700:Kinetics; D008099:Liver / Q000201:enzymology; D008297:Male; D009132:Muscles / Q000201:enzymology; D009369:Neoplasms / Q000201:enzymology*; D011770:Pyruvate Kinase / Q000037:antagonists & inhibitors*; D051381:Rats; D013329:Structure-Activity Relationship
D000227:Adenine Nucleotides; D000970:Antineoplastic Agents; D007527:Isoenzymes; D011770:Pyruvate Kinase