Synthesis of a trans-hydrindane nuclear analog of 11-desoxy-dihydro-prostaglandin E1.
Stereospecific synthesis of trans-hydrindanone 2a, a bicyclic analog of prostaglandin E1, via the trans- hydrindane beta-keto ester 8, is described. When tested in the guinea pig, 2a exhibited no effects on blood pressure and no broncho-constriction or dilation activity. Additionally, 2a failed to inhibit both ADP and collagen induced blood platelet aggregation.
D000818:Animals; D006168:Guinea Pigs; D007189:Indans; D008722:Methods; D011459:Prostaglandins E, Synthetic / Q000138:chemical synthesis* / Q000494:pharmacology
D007189:Indans; D011459:Prostaglandins E, Synthetic