[Quantitative model of human erythrocyte glycolysis. II. Effect of arsenate on glycolysis. Experimental study of the relationship between the rate of glycolysis and the ATP concentration].
The effect of arsenate on human erythrocyte glycolysis was studied. The stationary rate of glucose consumption rises and then drops with a gradual increase of arsenate concentration while ATP and glucose-6-phosphate concentrations drop monotonically. A plot of glucose consumption rate against ATP concentration gives a bell-like curve. This curve is the same for different donors if it is plotted in relative units with values at zero arsenate concentration taking for 100%, while the absolute values obtained for separate donors are very different. The normal (physiological) point is situated on the steeply descending part of the curve.
D000255:Adenosine Triphosphate / Q000378:metabolism*; D001149:Arsenates / Q000494:pharmacology*; D001151:Arsenic / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects*; D005958:Glucosephosphates / Q000378:metabolism; D006019:Glycolysis / Q000187:drug effects*; D006801:Humans
D001149:Arsenates; D005958:Glucosephosphates; D000255:Adenosine Triphosphate; D001151:Arsenic
Kolichestvennaia model' glikoliza éritrotsita cheloveka. II. Vliianie arsenata na glikoliz. Eksperimental'noe issledovanie zavisimosti skorosti glikoliza ot kontsentratsii ATF.