title: Cellular resistance to fluoride.
abstract: Cells cultured in vitro can be adapted to grow in the presence of high concentrations of fluoride by stepwise increasing the fluoride concentration in the culture medium. Such cells seem to have the ability to exclude fluoride from intracellular compartments.
mesh_terms: D000222:Adaptation, Physiological; D000621:Aminoisobutyric Acids / Q000378:metabolism; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002478:Cells, Cultured / Q000187:drug effects* / Q000378:metabolism; D004351:Drug Resistance; D005459:Fluorides / Q000494:pharmacology*; D011506:Proteins / Q000378:metabolism; D012969:Sodium Fluoride / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D000621:Aminoisobutyric Acids; D011506:Proteins; D012969:Sodium Fluoride; D005459:Fluorides