The effect of ascorbic acid (vitamin C) on two tumor cell lines in culture.
The effect of vitamin C on cell proliferation and DNA synthesis was investigated using two tumor cell lines Hep2 and KB. The results show that there was an increase in the ratio of dead to live cells and a decrease in the rate of DNA synthesis. The results also agree with other work carried out on animal experimental models which claimed that vitamin C may be involved in the arrest of neoplastic cell proliferation.
D001205:Ascorbic Acid / Q000494:pharmacology*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004273:DNA, Neoplasm / Q000096:biosynthesis; D009374:Neoplasms, Experimental / Q000188:drug therapy
D004273:DNA, Neoplasm; D001205:Ascorbic Acid