[Genetic markers in insulin-dependent juvenile diabetes].
A significant association has been established between insulin-dependent diabetes and HL-A. This was appraised in a selected series of 16 patients and 64 of their first-degree relatives by HL-A typing. The relatives also underwent a glucose tolerance test. The results showed a high incidence of B8 in the patients (31%, VS 15% in controls: p less than 0.01). A previously observed prevalence of Bw 15, however, was not noted. In addition, an increased incidence of Bw 35 was detected (38%, VS 23% in the controls: p less than 0.02). In the case of the relatives, no significant differences in HL-A frequency were apparent, nor could a relationship between HL-A phenotype and altered glucose tolerance be established. The true aetiopathogenetic significance of this association is discussed in the light of recent views concerning HL-A and diseases.
D002874:Chromosome Mapping; D002906:Chromosomes, Human, 6-12 and X; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D005951:Glucose Tolerance Test; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D010375:Pedigree; D010641:Phenotype
D006680:HLA Antigens
Marcatori genetici nel diabete giovanile insulino dipendente.