Pituitary apoplexy following chlorpromazine stimulation.
Chlorpromazine is frequently administered to patients with hyperprolactinemia to stimulate an increase in the serum levels of prolactin. A patient with a prolactin secreting adenoma is described in whom pituitary apoplexy developed in association with a hypotensive episode following the administration of 25 mg of chlorpromazine. Prolactin levels fell from more than 2,000 ng/ml to 340 ng/ml following infarction of the pituitary tumor. Pituitary apoplexy should be considered as a rare complication of chlorpromazine stimulation in a patient with a pituitary tumor.
D000238:Adenoma, Chromophobe / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D000328:Adult; D002746:Chlorpromazine / Q000009:adverse effects*; D006801:Humans; D007022:Hypotension / Q000139:chemically induced* / Q000150:complications; D008297:Male; D010900:Pituitary Diseases / Q000139:chemically induced*; D010911:Pituitary Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D011388:Prolactin / Q000097:blood / Q000378:metabolism
D011388:Prolactin; D002746:Chlorpromazine