Prazosin in the diagnosis and treatment of pheochromocytoma.
In a patient with paraganglioma, severe hypertension due to high levels of plasma norepinephrine was easily controlled with prazosin hydrochloride, 6 to 8 mg/day for 19 days before surgery. A prolonged antihypertensive response to the first two 1-mg doses suggested the presence of pheochromocytoma. This experience dramatizes the remarkable effectiveness of prazosin as a postsynaptic alpha-adrenergic receptor blocker and invites further trials of the drug for both the diagnosis and treatment of pheochromocytoma.
D000310:Adrenal Gland Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy; D008297:Male; D009638:Norepinephrine / Q000097:blood; D010673:Pheochromocytoma / Q000175:diagnosis / Q000188:drug therapy*; D011224:Prazosin / Q000494:pharmacology / Q000627:therapeutic use*; D011799:Quinazolines / Q000627:therapeutic use*
D011799:Quinazolines; D009638:Norepinephrine; D011224:Prazosin