Ascorbic acid and stress ulcer in the rat.
Rats were orally administered ascorbic acid at a dose of 30 g/liter during either total starvation, partial starvation, the activity-stress ulcer procedure, or the restraint-cold procedure. In four experiments, ascorbic acid failed to exert significant protective action against stomach ulcer formation and, in fact, may have potentiated the ulcerogenic process.
D000818:Animals; D001205:Ascorbic Acid / Q000009:adverse effects / Q000627:therapeutic use*; D003080:Cold Temperature; D004305:Dose-Response Relationship, Drug; D008297:Male; D005082:Physical Exertion; D051381:Rats; D012149:Restraint, Physical; D013217:Starvation / Q000150:complications*; D013270:Stomach / Q000473:pathology; D013276:Stomach Ulcer / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D013312:Stress, Physiological / Q000150:complications*
D001205:Ascorbic Acid