Comparison of the effect of drugs upon some commonly used measures of bowel transit time.
1 To study the effect of drugs on methods of assessment of gut transit time a double-blind study of the effect of single doses of placebo, oxyphenisatin, anthracene purgatives, (+)-norpseudoephedrine and a combined preparation of (+)-norpseudophedrine and senna was carried out in ten normal volunteers. Gut transit time was assessed by dye and radio-opaque marker methods. 2 It was possible to demonstrate the effect of the anthracenes but not oxyphenisatin on gut transit time. 3 More sophisticated statistical techniques were required to demonstrate the retarding effect of the sympathomimetic amine and its reversal by senna. 4 Statistical analysis shows that assessment of intestinal transit time by dye or pellet methods gives identical information.
D000328:Adult; D000873:Anthracenes / Q000494:pharmacology; D001466:Barium Sulfate; D002329:Carmine; D003672:Defecation / Q000187:drug effects; D005243:Feces / Q000032:analysis; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006801:Humans; D008297:Male; D010114:Oxyphenisatin Acetate / Q000494:pharmacology; D010665:Phenylpropanolamine / Q000494:pharmacology; D012676:Senna Extract / Q000494:pharmacology; D013997:Time Factors
D000873:Anthracenes; D001466:Barium Sulfate; D010665:Phenylpropanolamine; D012676:Senna Extract; D002329:Carmine; D010114:Oxyphenisatin Acetate