Defective microbicidal function of neutrophils in haematological malignancies and lymphomas: correction by levamisole in vitro.
The ability of neutrophils to kill Candida guilliermondii was investigated in patients with various haematological malignancies and lymphomas. Twelve of 24 patients showed significant depression of Candida killing in vitro in comparison with normal controls. The addition of levamisole to the test system, in a concentration of 1 X 10(-7)M, resulted in the correction of the Candida killing defect in 7 of 8 patients.
D002175:Candida; D006801:Humans; D066298:In Vitro Techniques; D007938:Leukemia / Q000097:blood*; D007978:Levamisole / Q000494:pharmacology*; D008223:Lymphoma / Q000097:blood*; D009504:Neutrophils / Q000187:drug effects* / Q000502:physiology; D013268:Stimulation, Chemical
D007978:Levamisole