title: Sequence organization of the beta-globin mRNA precursor.
abstract: The sequence organization of the beta-globin mRNA precursor has been determined directly by analyzing the resistant fragments from the RNase A digestion of the precursor RNA-globin cDNA hybrid. Three fragments are obtained which proves that the beta-globin mRNA sequence in its precursor is split into three discontinuous segments. The two intervening sequences in the beta-globin gene are therefore transcribed and removed during mRNA maturation.
mesh_terms: D001483:Base Sequence; D005914:Globins / Q000235:genetics*; D009694:Nucleic Acid Precursors / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics*; D012260:Ribonucleases / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D009694:Nucleic Acid Precursors; D012333:RNA, Messenger; D005914:Globins; D012260:Ribonucleases