Effects of cycloheximide and streptovitacin A on protein synthesis and gastric secretion in rats.
Cycloheximide and streptovitacin A administered in vivo to rats display a similar dual effect on the labelling of soluble liver proteins by valine-14C, and result in a similar enhancement of liver uridine kinase activity. On the other hand, in pylorus-ligated rats, both antibiotics markedly depress gastric secretion, acid output, and the level of mucoproteins and proteolytic activity in secreted juice. Streptovitacin A on a molar basis was in all cases 5 approximately 8 times more effective than cycloheximide.
D000818:Animals; D003513:Cycloheximide / Q000031:analogs & derivatives* / Q000494:pharmacology*; D005260:Female; D005750:Gastric Juice / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D014176:Protein Biosynthesis; D051381:Rats; D014541:Uridine Kinase / Q000378:metabolism
D003513:Cycloheximide; D014541:Uridine Kinase