Reversal of betamethasone-induced inhibition of intestinal calcium absorption by 1alpha-hydroxycholecalciferol.
The intestinal absorption of calcium has been studied in conscious, unstressed pigs, using a modification of the double isotope technique. The oral administration of betamethasone (1 mg/day) to four pigs (25--33 kg) for 4 weeks reduced the calcium absorption coefficient, calculated after the intravenous and oral administration of 47Ca2+, by a mean value of 66%. The oral administration of 1alpha-hydroxycholecalciferol (2 microgram/day) in combination with beta-methasone (1 mg/day) for a further 4 weeks returned the absorption coefficient to the control value.
D000818:Animals; D001623:Betamethasone / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism*; D005260:Female; D006887:Hydroxycholecalciferols / Q000494:pharmacology*; D007408:Intestinal Absorption / Q000187:drug effects*; D008297:Male; D010710:Phosphates / Q000378:metabolism; D013552:Swine
D006887:Hydroxycholecalciferols; D010710:Phosphates; D001623:Betamethasone; D002118:Calcium