Human interferon and its inducers: clinical program overview at Roswell Park Memorial Institute.
An overview of the clinical interferon program at Roswell Park Memorial Institute is presented. Purified fibroblast interferon and a novel inducer of human interferon [rIn-r(C12,U)n] are being evaluated for possible antiviral, antiproliferative, and immunomodulatory activities in patients with cancer.
D004341:Drug Evaluation; D005347:Fibroblasts / Q000276:immunology; D006801:Humans; D007109:Immunity; D007369:Interferon Inducers / Q000494:pharmacology*; D007372:Interferons / Q000494:pharmacology*; D009369:Neoplasms / Q000188:drug therapy*; D011070:Poly I-C / Q000494:pharmacology*; D011072:Poly U / Q000494:pharmacology*; D012106:Research; D014777:Virus Diseases / Q000188:drug therapy*
D007369:Interferon Inducers; D011072:Poly U; D007372:Interferons; D011070:Poly I-C