Dextran induced hypoalbuminaemia as a model for the study of influences of protein binding on the pharmacokinetics of drugs.
A model for examination of the effect of hypoalbuminaemia on drug pharmacokinetics in laboratory animal is described. The model has been used to investigate the effect of protein binding on the kinetics of sulphadimethoxine in rabbits. A greater volume of distribution of sulphadimethoxine is shown in the dextran induced hypoalbuminaemic rabbits in comparison with control animals. It is concluded that the suggested model is convenient for investigation of the influences of protein binding on drug pharmacokinetics.
D000818:Animals; D003911:Dextrans / Q000008:administration & dosage; D007019:Hypoproteinemia / Q000097:blood / Q000139:chemically induced / Q000378:metabolism*; D007263:Infusions, Parenteral; D008297:Male; D008954:Models, Biological; D011485:Protein Binding; D011817:Rabbits; D012709:Serum Albumin / Q000378:metabolism*; D013412:Sulfadimethoxine / Q000378:metabolism*
D003911:Dextrans; D012709:Serum Albumin; D013412:Sulfadimethoxine