Increased adenylate cyclase activity and rapid weight loss following intraseptal injection of cholera toxin.
Cholera toxin, stereotaxically injected into the medial septal nucleus of the rat, leads within 24 h to a dramatic decrease in body weight and an increase in septal adenylate cyclase activity. Toxin-treated rats drink one-third the water of vehicle-treated animals while excreting two-and-one half times the urine. Food intake over the 24-h period is depressed to 13% of control but feces production was normal. The dramatic increase of urinary output suggests that cholera toxin activates a septal adenylate cyclase system which supressess the release of antidiuretic hormone. Cholera toxin injection into the septum may be a unique alternative to electrical stimulation for investigating septal involvement in the regulation of neuronal and metabolic processes.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D001921:Brain / Q000201:enzymology; D002772:Cholera Toxin / Q000008:administration & dosage / Q000494:pharmacology*; D004558:Electric Stimulation; D007267:Injections; D008297:Male; D051381:Rats; D013997:Time Factors
D002772:Cholera Toxin; D000262:Adenylyl Cyclases