title: Platelet satellitism and phagocytosis by neutrophils: association with antiplatelet antibodies and lymphoma.
abstract: Satellitism and phagocytosis of platelets by neutrophils in EDTA anticoagulated blood have been considered in vitro phenomena without clinical significance. We observed these in a patient with acute, severe thrombocytopenic purpura who subsequently proved to have malignant lymphoma. Wide oscillations in the platelet count were noted and recurrent, severe gastrointestinal bleeding occurred even when the platelet count was normal. Platelet function was abnormal as shown by decreased platelet adhesion to glass beads, absence of a secondary wave of aggregation in response to ADP and eqinephrine, and no aggregation with collagen. Suspension of control platelets in the patient's plasma induced similar aggregation defects in the control platelets. Combination chemotherapy resulted in regression of lymphadenopathy, but platelet abnormalities and bleeding persisted. Platelet satellitism and phagocytosis by neutrophils seen on peripheral blood films may be associated with true thrombocytopenia, abnormal platelet function and bleeding with an underlying systemic disease.
mesh_terms: D000906:Antibodies; D001772:Blood Cell Count; D001780:Blood Coagulation Tests; D001792:Blood Platelets / Q000276:immunology / Q000502:physiology*; D005260:Female; D006801:Humans; D008223:Lymphoma / Q000097:blood*; D008875:Middle Aged; D009504:Neutrophils; D010587:Phagocytosis; D010973:Platelet Adhesiveness; D010974:Platelet Aggregation
chemical_list: D000906:Antibodies