[Effect of methylapogalanthamine on the tone of cerebral, extracranial and peripheral vessels].
It was established in acute experiments on anesthetised and nonanesthetised cats by means of resistography that methylapogalanthamine decreased the total arterial pressure, the tone of cerebral vessels, extracranial and femoral vessels. The effect of the latter was more pronounced. A two-phase reaction (dilatation-constriction) was not rare. Methylapogalanthamine diminished the constriction reaction of intra- and extracranial vessels in response to st mulation of the cervical sympathetic nerves. The vasodilator action of methylapogalanthamine was enhanced by anesthesia and decreased by rausedyl.
D000768:Anesthesia, General; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001808:Blood Vessels / Q000187:drug effects*; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects; D005260:Female; D005702:Galantamine / Q000008:administration & dosage / Q000494:pharmacology* / Q000031:analogs & derivatives; D006614:Hindlimb / Q000098:blood supply; D007269:Injections, Intra-Arterial; D007275:Injections, Intravenous; D008297:Male; D013564:Sympathetic Nervous System / Q000502:physiology; D014655:Vascular Resistance / Q000187:drug effects
D005702:Galantamine; C013604:methylapogalanthamine
Vliianie metilapogalantamina na tonus mozgovykh, vnecherepnykh i perifericheskikh sosudov.