title: [Effect of cocaine molecule fragments on the central nervous system].
abstract: The influence of ecgonine, tropine, tropinon, and some of their derivatives, propan, N-methylpyrrholidine, N-methylpiperidine on impulse summation in the central nervous system, conditioned reflex of avoidance, antagonism to hexenal, synergisim to cocaine and also their toxicity (LD50) have been studied under experimental conditions. As shown, benzoyl-ecgonine, ecgonine methyl ester, ecgonine, tropine, pseudotropine, carbomethoxytropinon, tropinon, tropine, tropan N-methylpyrrolidine, and N-methylpiperidine produced a pronounced stimulating effect on the central nervous system activity; in this respect they were similar to cocaine. The following conclusions were made: the substances whose molecules contained tropan structure or one of its fragments possess the central stimulating effect. The stimulating effect of cocaine on the central nervous system could be due to the tropan fragment of its molecule.
mesh_terms: D000779:Anesthetics, Local; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects*; D055598:Chemical Phenomena; D002621:Chemistry; D003042:Cocaine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity; D004357:Drug Synergism; D006591:Hexobarbital / Q000037:antagonists & inhibitors; D007928:Lethal Dose 50; D051379:Mice; D011817:Rabbits; D011930:Reaction Time / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000779:Anesthetics, Local; D006591:Hexobarbital; D003042:Cocaine
vernacular_title: Deĭstvie fragmentov molekuly kokaina na tsentral'nuiu nervnuiu sistemu.