[Effect of local iontophoretic application of acetylcholine and serotonin on rabbit superior cervical ganglion neurons].
The effect of iontophoretically applied acetylcholine and serotonin (5-hydroxytryptamine) on the neurons of the rabbit isolated superior cervical ganglion was studied by means of intracellular recording. It is found that the ganglion cell soma has only nicotinic receptors and no muscarinic receptors; nicotinic receptors are dispersed nonuniformly on the surface of the soma membrane. Spontaneous EPSPs were observed due to ACh application, which indicates excitation of presynaptic terminals. In about a half of ganglion neurons the soma possessed serotonin receptors.
D000109:Acetylcholine / Q000008:administration & dosage*; D000818:Animals; D004594:Electrophysiology; D005071:Evoked Potentials; D005725:Ganglia, Autonomic / Q000032:analysis / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D007478:Iontophoresis; D011817:Rabbits; D011976:Receptors, Muscarinic / Q000032:analysis; D011978:Receptors, Nicotinic / Q000032:analysis; D012701:Serotonin / Q000008:administration & dosage*
D011976:Receptors, Muscarinic; D011978:Receptors, Nicotinic; D012701:Serotonin; D000109:Acetylcholine
Deĭstvie lokal'noĭ ionoforeticheskoĭ applikatsii atsetilkholina i serotonina na neĭrony verkhnego sheĭnogo gangliia krolika.