Hepatic fibrosis in schistosomiasis: egg granulomas secrete fibroblast stimulating factor in vitro.
Cytosol extracts and culture supernatants of isolated egg granulomas obtained from livers of mice with Schistosoma mansoni infection stimulated fibroblasts to incorporate tritiated thymidine and to proliferate in vitro. This finding suggests that hepatic granulomas may play a role in regulating hepatic fibrosis in Schistosoma mansoni infections.
D000818:Animals; D002455:Cell Division; D005347:Fibroblasts / Q000473:pathology; D006099:Granuloma / Q000150:complications / Q000209:etiology* / Q000378:metabolism; D006133:Growth Substances / Q000378:metabolism*; D007249:Inflammation / Q000503:physiopathology; D008103:Liver Cirrhosis / Q000209:etiology*; D051379:Mice; D012550:Schistosoma mansoni; D012552:Schistosomiasis / Q000150:complications / Q000473:pathology* / Q000503:physiopathology
D006133:Growth Substances