title: Effects of hypoxemia upon aminoglycoside serum pharmacokinetics in animals.
abstract: Hypoxemia causes significant alterations in aminoglycoside serum pharmacokinetics in adult rats and newborn rabbits. The aminoglycoside serum clearances were diminished in hypoxemic animals. Comparisons of intravenous and intramuscular administration imply a delay in uptake of drug from intramuscular injection sites under hypoxemic conditions.
mesh_terms: D000583:Amikacin / Q000097:blood*; D000818:Animals; D000831:Animals, Newborn / Q000097:blood; D005839:Gentamicins / Q000097:blood*; D006207:Half-Life; D000860:Hypoxia / Q000097:blood*; D007612:Kanamycin / Q000031:analogs & derivatives*; D008297:Male; D011817:Rabbits; D051381:Rats
chemical_list: D005839:Gentamicins; D007612:Kanamycin; D000583:Amikacin