title: Least-squares method for restriction mapping.
abstract: A least-squares procedure has been developed to aid in deriving restriction-fragment maps once the order of cutsites has been determined. A computer program which carries out this method can be used to map either linear or circular molecules.
mesh_terms: D002874:Chromosome Mapping; D003201:Computers; D004247:DNA; D004262:DNA Restriction Enzymes; D004274:DNA, Recombinant; D008433:Mathematics
chemical_list: D004274:DNA, Recombinant; D004247:DNA; D004262:DNA Restriction Enzymes