Effect of 5-bromodeoxyuridine on differentiation. II. The effect of early BUdR treatment on gastrulation of sea urchin embryos.
BUdR treatment of early cleavage stages is more effective on gastrulation the earlier the drug is administered before the 16-cell stage. The distribution of percentages of embryos gastrulating is in good agreement with the theoretical calculated values presented in part I and permit the assumption that BUdR may act by preventing normal transcription at, or shortly after, the 16-cell stage.
D000818:Animals; D001973:Bromodeoxyuridine / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects*; D005855:Germ Layers / Q000166:cytology*; D012617:Sea Urchins; D013997:Time Factors; D014158:Transcription, Genetic / Q000187:drug effects
D001973:Bromodeoxyuridine