Ultraviolet light induces epidermal ornithine decarboxylase activity.
Hairless mice were irradiated with fluorescent sun lamp tubes (peak emission at 313 nm). A singificant increase in epidermal ornithine decarboxylase activity was found after 2 hr. A maximum 80-fold increase was found after 24 hr, decreasing again at 48 hr. Epidermal DNA synthesis was decreased at 6 hr and 24 hr increasing to a maximum 48 hr after irradiation. These results show that polyamine biosynthetic enzyme activity precedes the delayed increase in epidermal DNA synthesis following ultraviolet light exposure.
D000818:Animals; D002262:Carboxy-Lyases / Q000378:metabolism*; D004247:DNA / Q000096:biosynthesis; D004817:Epidermis / Q000378:metabolism / Q000528:radiation effects*; D005260:Female; D051379:Mice; D008819:Mice, Nude; D009955:Ornithine Decarboxylase / Q000378:metabolism*; D014466:Ultraviolet Rays
D004247:DNA; D002262:Carboxy-Lyases; D009955:Ornithine Decarboxylase