title: Drug resistance studies with topical antiseptics.
abstract: Species of Proteus, Serratia, and Pseudomonas became resistant to chlorhexidine after five to eight transfers in vitro. Cross-resistance to benzalkonium chloride also was detected. Resistance to povidone-iodine was not encountered. Chlorhexidine resistance was stable after drug-free transfers of Serratia and Pseudomonas but was transitory for Proteus.
mesh_terms: D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D001548:Benzalkonium Compounds / Q000494:pharmacology; D002710:Chlorhexidine / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D011206:Povidone-Iodine / Q000494:pharmacology
chemical_list: D000891:Anti-Infective Agents, Local; D001548:Benzalkonium Compounds; D011206:Povidone-Iodine; D002710:Chlorhexidine