Effect of sparteine sulfate on uterine prostaglandin F in the rat.
Indomethacin, an inhibitor of prostaglandin synthetase, added to an in vitro bath in a concentration of 1, 5, and 10 X 10(-6) g/ml reduced sparteine-induced contractions of isolated uterine segments from pregnant rats. Contractions induced by prostaglandin F2alpha and acetylcholine were not reduced. Sparteine increased the prostaglandin F content of the blood and uterine tissue in the pregnant but not in the nonpregnant rat. This increase was significantly reduced by the administration of indomethacin (10 mg/kg). The present study suggests that the mechanism of sparteine action is mediated through a prostaglandin F system.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D007213:Indomethacin / Q000008:administration & dosage / Q000494:pharmacology; D011247:Pregnancy; D011448:Prostaglandin Antagonists / Q000494:pharmacology; D011460:Prostaglandins F / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology; D051381:Rats; D013034:Sparteine / Q000494:pharmacology*; D014590:Uterine Contraction / Q000187:drug effects; D014599:Uterus / Q000378:metabolism*
D011448:Prostaglandin Antagonists; D011460:Prostaglandins F; D013034:Sparteine; D000109:Acetylcholine; D007213:Indomethacin