Daunorubicin, daunorubicinol and DNA plasma kinetics after I.V. administration of daunorubican-DNA complex in the rabbit.
The pharmacokinetics of daunorubicin and daunorubin-DNA complex were studied in the rabbit after i.v. bolus injection and a 4hr infusion period. The plasma levels of daunorubicin and daunorubicinol were measured by high-pressure liquid chromatography and the DNA plasma levels by means of 125I labelled DNA. The results demonstrated a slower distribution of the complex; however, the more rapid decrease in the plasma levels of daunorubicin than that of DNA suggested that this complex essentially constitutes a "daunorubicin circulating pool" from which the drug diffuses more slowly than after the administration of uncomplexed daunorubicin.
D000818:Animals; D001682:Biological Availability; D004247:DNA / Q000008:administration & dosage / Q000097:blood*; D003630:Daunorubicin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood*; D004338:Drug Combinations; D005260:Female; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D011817:Rabbits
D004338:Drug Combinations; D004247:DNA; D003630:Daunorubicin