[Action of fentanyl, droperidol and diazepam on the contractile function of the isolated human myometrium].
The action of the analgesic phenthanyl, neuroleptic-droperidol and tranquilizer--diazepam on the contractile function of an isolated human myometrium was investigated. Phenthanyl (5.10(-8)--5.10(-7) g/ml) produced a stimulating influence on the contractility of an isolated human myometruim. When in relatively low concentrations (5.10(-7)--2.10(-6) g/ml) droperidol caused a stimulating effect and in higher concentrations (8.10(-6)--2.10(-5) g/ml) it exerted a biphasic action on the contractile function of an isolated myometrium, viz. first stimulation and then--inhibition. Diazepam (1.10(-12))--5.10(-8) g/ml suppressed the spontaneous periodic activity of an isolated human myometrium.
D003975:Diazepam / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004329:Droperidol / Q000494:pharmacology*; D005260:Female; D005283:Fentanyl / Q000494:pharmacology*; D006801:Humans; D011247:Pregnancy; D013997:Time Factors; D014590:Uterine Contraction / Q000187:drug effects*
D004329:Droperidol; D003975:Diazepam; D005283:Fentanyl
Deistvie fentanila, droperidola i diazepama na sokratitel'nuiu funktsiiu izolirovannogo miometriia cheloveka.