Ultraviolet light inhibition of oriented fibrin formation in psoriasis.
Radially-oriented fibrin crystallization was induced by incubation of blood from psoriatic patients with killed Pseudomonas aeruginosa. The phenomenon was inhibited by irradiation of the buffy coat in plasma with UV-B. It was not inhibited by UV-A unless trioxsalen had been added. Addition of UV-A-irradiated plasma to non-irradiated buffy coat also inhibits the fibrin formation.
D003460:Crystallization; D005337:Fibrin / Q000528:radiation effects*; D006801:Humans; D008297:Male; D011565:Psoriasis / Q000097:blood*; D014307:Trioxsalen / Q000494:pharmacology; D014466:Ultraviolet Rays
D005337:Fibrin; D014307:Trioxsalen