title: [Effect of high-altitude hypoxia on the course of experimental mitral heart defect].
abstract: The course of dosed insufficiency of the mitral valve in animals under lowland conditions is characterized by marked compensatory capacity of the organism. Under the effect of high-altitude hypoxia (3,200 m), the disease of the mitral valve is attended with overloading of the left atrium with the volume of blood and leads to acute hypertension of the pulmonary artery with subsequent decompensation of the right heart. In animals with mitral valvular disease under conditions of high altitude, strophanthin K produces a sufficiently complete cardiotonic effect which prevents weakening of the myocardial contractions, particularly in the early period of the defect in the mitral valve.
mesh_terms: D000531:Altitude; D000818:Animals; D001794:Blood Pressure; D004285:Dogs; D005260:Female; D006321:Heart / Q000503:physiopathology; D006976:Hypertension, Pulmonary / Q000209:etiology; D000860:Hypoxia / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D008944:Mitral Valve Insufficiency / Q000503:physiopathology*; D010101:Oxygen Consumption; D011652:Pulmonary Circulation
vernacular_title: Vliianie vysokogornoĭ gipoksii na technenie eksperimental'nogo mitral'nogo poroka serdtsa.