Exponential decrease during aging and random lifetime of mouse spermatogonial stem cells.
Variation in the number of spermatogonial stem cells during the lifespan of the mouse was examined by assaying the number of clonogenic cells, that is, spermatogenic stem cells, surviving known doses of radiation. The results indicated that the stem cell number decreased exponentially with age.
D000375:Aging; D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D008297:Male; D051379:Mice; D013093:Spermatogonia / Q000166:cytology*; D013094:Spermatozoa / Q000166:cytology*; D013737:Testis / Q000166:cytology* / Q000528:radiation effects