[Activity of the indicator enzymes of liver subcellular structures with the prolonged administration of Valexon].
The free and unprecipitated activity of succindehydrogenase and glucose-6-phosphatase, as well as of that of glucose-6-phosphate-dehydrogenase in the rats liver was determined. The animals received for a long time (1--3 and 6 months) a new organophosphorus pesticide valexon (0.0-diethyl thiophosphoryl-oxyiminophenylnitryle acetate) by mouth in doses of 31 mg/kg and 3.1 mg/kg which corresponds to 1/20 and 1/200 LD50. The earliest changes (after 1 month) include: falling activity of hexokinase and a rise in that of glucose-6-phosphatase and succindehydrogenase, pointing to the damage of microsomes and mitochondria supervenes in 1 and 6 months time after introduction, respectively. The role of an early injury of microsomes and of disturbed first stages of glucose metabolism in the mechanism of the valexon action is suggested.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation / Q000187:drug effects; D007306:Insecticides / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D009946:Organothiophosphorus Compounds; D051381:Rats; D013347:Subcellular Fractions / Q000187:drug effects / Q000201:enzymology; D013997:Time Factors
D007306:Insecticides; D009946:Organothiophosphorus Compounds
Aktivnost' indikatornykh fermentov subkletochnykh struktur pecheni pri dlitel'nom vvedenii valeksona.