title: Effect of antirheumatic drugs on proteinases in synovia of patients with rheumatoid arthritis.
abstract: Synovia and synovial fluid proteinases were determined in 21 patients with rheumatoid arthritis who were using different kinds of antirheumatic medications. Significantly lower cathepsin B1-like proteinase activity (only 10% of control) was found in the synovial fluid of patients with chloroquine treatment, and significantly lower neutral trypsin-substrate hydrolysing proteinase activity (about 30% of control) was found in the synovia of patients with phenylbutazone treatment. No significant differences were found with other medications: gold, indomethacin, cortisone, acetylsalicyclic acid. No definitive correlations between disease activity parameters and proteinase activities could be found.
mesh_terms: D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001172:Arthritis, Rheumatoid / Q000201:enzymology*; D002403:Cathepsins / Q000037:antagonists & inhibitors; D005260:Female; D006801:Humans; D011480:Protease Inhibitors; D013582:Synovial Fluid / Q000201:enzymology*; D014361:Trypsin Inhibitors
chemical_list: D000893:Anti-Inflammatory Agents; D011480:Protease Inhibitors; D014361:Trypsin Inhibitors; D002403:Cathepsins