Sensitizing activity of 9,13-dicis retinal in bleached photoreceptors of the skate.
9,13-dicis Retinal was externally applied to photoreceptors of isolated skate retina that previously had been desensitized by bleaching irradiation. This treatment led to a significant lowering of photoreceptor threshold and to the intracellular formation of isorhodopsin II, an artificial visual pigment containing 9,13-dicis retinal as its chromophore. These results suggest that isorhodopsin II can function in situ to promote an increase in the visual sensitivity of skate photoreceptors.
D000818:Animals; D003623:Dark Adaptation; D005399:Fishes; D010786:Photoreceptor Cells / Q000187:drug effects* / Q000528:radiation effects; D012172:Retinaldehyde / Q000494:pharmacology*; D012243:Rhodopsin / Q000096:biosynthesis; D013237:Stereoisomerism; D014785:Vision, Ocular / Q000187:drug effects; D014801:Vitamin A / Q000031:analogs & derivatives*
D014801:Vitamin A; D012243:Rhodopsin; D012172:Retinaldehyde