Pharmacokinetics of 1-desamino-8-D-arginine vasopressin (DDAVP) in patients with central diabetes insipidus.
The pharmacokinetic parameters and biological duration of action of DDAVP were measured in five patients with central diabetes insipidus of differing severity. Plasma half-life correlated significantly with the duration of action (r = 0.89, P less than 0.05), 0ut there was no correlation between the severity of diabetes insipidus and either plasma half-life or duration of action of DDAVP.
D000328:Adult; D000368:Aged; D001127:Arginine Vasopressin / Q000378:metabolism*; D003894:Deamino Arginine Vasopressin / Q000097:blood / Q000378:metabolism*; D003919:Diabetes Insipidus / Q000378:metabolism*; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D008657:Metabolic Clearance Rate
D001127:Arginine Vasopressin; D003894:Deamino Arginine Vasopressin