Effect of methyl ester of aristolic acid from Aristolochia indica Linn. on fertility of female mice.
Methyl ester of aristolic acid, a pure compound isolated from the roots of Aristolochia indica (Linn.), was found to exert 100% abortifacient activity at a single oral dose of 60 mg/kg b. wt when administered on 6th or 7th day of pregnancy; 20 and 25% abortifacient effect were observed at the same dose on day 10 and 12, respectively.
D000019:Abortifacient Agents / Q000494:pharmacology; D000818:Animals; D004148:Dioxolanes / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D051379:Mice; D010616:Phenanthrenes / Q000494:pharmacology*; D010946:Plants, Medicinal; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects
D000019:Abortifacient Agents; D004148:Dioxolanes; D010616:Phenanthrenes