[Fibrinogen: structure, function and interaction with proteins and cells].
The dimerous three-chained protein fibrinogen has at its disposal different functional zones which are included in the process of polymerisation and which possess importance for the specific reaction of fibrinogen with certain cells. The present paper is particularly engaged with the activation of fibrinogen by thrombin and with the mechanism of the arrangement of the activated units of fibrinogen concerning the fibrin fibre. Finding concerning the interaction of the platelets with fibrinogen connected to sepharose plead for the fact that a change of conformation in the molecule of fibrinogen precedes the specific platelet reaction.
D001792:Blood Platelets / Q000502:physiology; D005337:Fibrin / Q000096:biosynthesis; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D011487:Protein Conformation; D013917:Thrombin
D005337:Fibrin; D005340:Fibrinogen; D013917:Thrombin
Fibrinogen: Struktur, Funktion und Interaktion mit Proteinen und Zellen.