Growth of some attenuated influenza A viruses in hamsters.
The replication of three attenuated influenza viruses in SPF hamsters inoculated by aerosol was investigated. Strains A2-Eng, A2-Victoria, ts-1-[E] A2-Victoria recombinant, and the RIT 4050 strain all multiplied to high titers in hamster lungs and induced both primary and secondary serological responses. Recombinant strain, A/AA/6/60-A2-Vic (CR22) multiplied to lower titers in hamsters. Differences were observed between the infectivity of different strains for hamsters, the wild-type viruses A2-Eng and A2-Vic being the most infective.
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D006224:Cricetinae; D009980:Influenza A virus / Q000235:genetics / Q000254:growth & development* / Q000472:pathogenicity; D008168:Lung / Q000382:microbiology; D009976:Orthomyxoviridae Infections / Q000276:immunology / Q000382:microbiology*; D011995:Recombination, Genetic; D014779:Virus Replication
D000914:Antibodies, Viral