The lack of an effect of cholinergic agonists on anterior pituitary prolactin production in vitro.
The addition of dopamine to anterior pituitary incubations resulted in a marked decrease (88% for 3H prolactin and 69% for RIA prolactin) in prolactin release. Incubation with the cholinergic agonists carbacol, arecoline and nicotine resulted in no significant change in prolactin secretion.
D000818:Animals; D001115:Arecoline / Q000494:pharmacology; D002217:Carbachol / Q000494:pharmacology; D004298:Dopamine / Q000494:pharmacology; D005260:Female; D066298:In Vitro Techniques; D009538:Nicotine / Q000494:pharmacology; D010277:Parasympathomimetics / Q000494:pharmacology*; D010903:Pituitary Gland, Anterior / Q000187:drug effects* / Q000378:metabolism; D011388:Prolactin / Q000096:biosynthesis*; D051381:Rats
D010277:Parasympathomimetics; D001115:Arecoline; D009538:Nicotine; D002217:Carbachol; D011388:Prolactin; D004298:Dopamine