[The influence of chenodeoxycholic acid on the concentrations of nonsulfated bile acids in the small and large intestinal mucosa of rats (author's transl)].
In male Wistar rats nonsulfated bile acids of small and large intestinal wall and feces are analysed after 2, 5, 9 and 14 days of oral administration of 20 or 90 mg chenodeoxycholic acid (CDCA)/kg. Development of body, intestinal, and fecal weights is assessed. A transient reduction of daily body weight gain and small and large intestinal weights is compensated after 14 days. Fecal weights are above controls under 20 mg/kg, below controls under 90 mg/kg. Containing about 2 mg, i.e. nearly 4% of the bile acid pool, the intestinal wall holds four times more bile acids than the liver. Under CDCA administration bile acid concentrations in the small intestinal wall and feces rise, and remain almost unchanged in the colonic wall. Changes after CDCA administration suggest that bile acid absorption is accompanied by an increase in mucosal bile concentration. In the colonic wall the increase in bile acid concentration after CDCA administration correlates with the passive permeability coefficient.
D000818:Animals; D001647:Bile Acids and Salts / Q000032:analysis*; D002635:Chenodeoxycholic Acid / Q000494:pharmacology*; D005243:Feces / Q000032:analysis; D007413:Intestinal Mucosa / Q000032:analysis / Q000187:drug effects*; D007420:Intestine, Large; D007421:Intestine, Small; D008297:Male; D051381:Rats
D001647:Bile Acids and Salts; D002635:Chenodeoxycholic Acid
Der Einfluss von Chenodesoxycholsäure auf die Konzentration nichtsulfatierter Gallensäuren in der Dünn- und Dickdarmschleimhaut der Ratte.