The influence of supraspinal impulse activity on the intra-axonal transport of acetylcholine, choline acetyltransferase and acetylcholinesterase in rat motor neurons.
The effect of supraspinal impulse activity upon the intra-axonal transport of acetylcholine (ACh),  ACh esterase (AChE) and cholineacetyltransferase (CAT) in rat sciatic nerve has been studied. A decreased inpulse activity was obtained by spinal cord transsection (SCT) in the thoracic region 18 h, 6 days or 20 days before killing the rats. An increased neuronal activity was obtained by exercising the rats in a commercial rodent treadmill a couple of hours per day for 14 days. The amounts of substances which had accumulated in the sciatic nerve segments relative to a nerve crush performed 12 or 18 h. earlier were used to calculate the intra-axonal transport. The amounts of proximo-distal transported ACh decreased markedly with time after the SCT, while the proximo-distal transport of AChE-activity increased. Physical exercise appeared to increase ACh-transport. Thus, input to motor pericarya from supraspinal centers may regulate intra-axonal transport from the cell body of motor neurons into their axons.
D000109:Acetylcholine / Q000378:metabolism*; D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D001369:Axons / Q000201:enzymology / Q000378:metabolism*; D001692:Biological Transport; D002795:Choline O-Acetyltransferase / Q000378:metabolism*; D005260:Female; D008297:Male; D009046:Motor Neurons / Q000201:enzymology / Q000378:metabolism* / Q000502:physiology; D009409:Nerve Crush; D005082:Physical Exertion; D051381:Rats; D012584:Sciatic Nerve / Q000378:metabolism / Q000502:physiology / Q000601:surgery; D013116:Spinal Cord / Q000601:surgery
D002795:Choline O-Acetyltransferase; D000110:Acetylcholinesterase; D000109:Acetylcholine