Decrease in adrenergic axon sprouting in the senescent rat.
When the septal area in young adult rats is denervated by a lesion of the fimbria-fornix, adrenergic fibers proliferate within the denervated area. The same operation performed on aged animals gives rise to a qualitatively similar but quantitatively less pronounced response. This reduction in reactive growth may reflect a decreased capacity of the aged brain to remodel its circuitry and restore lost function.
D000320:Adrenergic Fibers / Q000166:cytology / Q000254:growth & development*; D000375:Aging; D000818:Animals; D002454:Cell Differentiation; D006624:Hippocampus / Q000166:cytology; D008297:Male; D051381:Rats; D012686:Septal Nuclei / Q000166:cytology