[On cytocidic effect of exogenous modified DNA].
The number of defects of the secondary structure and dispersions of the molecular weights of DNA preparations were studied before and after their gamma-irradiation within a 5-2500 krad range of doses. These results are compared with the ability of the irradiated preparations to induce death of thymocytes irradiated in vivo during their combined incubation in vitro. It is established that the DNA biological activity is a result of the presence in the total preparation of molecule fractions of 5.10(6) or 1.10(6) Daltons with 3 or 50-80 defects of the secondary structure.
D000818:Animals; D002470:Cell Survival / Q000528:radiation effects; D004247:DNA / Q000378:metabolism*; D004307:Dose-Response Relationship, Radiation; D066298:In Vitro Techniques; D008970:Molecular Weight; D009690:Nucleic Acid Conformation; D013154:Spleen; D013950:Thymus Gland / Q000378:metabolism / Q000528:radiation effects*
D004247:DNA
O tsitotsidnom deĭstvii ekzogennoĭ modifitsirovannoĭ DNK.