title: Early intermediates in the biosynthesis of ansamycins. I. Isolation and identification of protorifamycin I.
abstract: A mutant strain derived from Nocardia mediterranei N813 was found to accumulate a number of novel ansamycins structurally related to the protostreptovaricins and to rifamycin W. One of the main components of this ansamycin complex, protorifamycin I (8-deoxyrifamycin W), was purified and identified by means of chemical and spectroscopic methods.
mesh_terms: D055598:Chemical Phenomena; D002621:Chemistry; D005285:Fermentation; D008826:Microbial Sensitivity Tests; D009154:Mutation; D009615:Nocardia / Q000235:genetics / Q000378:metabolism; D012294:Rifamycins / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology
chemical_list: D012294:Rifamycins