Platelet monoamine oxidase and epinephrine-induced platelet aggregation.
Platelet MAO activity and the aggregation response to epinephrine, ADP, and collagen were measured in normal subjects. There was a direct correlation between the amount of platelet MAO activity and the per cent aggregation induced by 1 and 2 micrometer epinephrine. There were lesser correlations between platelet MAO and ADP or collagen-induced aggregation. These findings suggest that platelet MAO may play a role in determining the response of human platelets to epinephrine.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D001792:Blood Platelets / Q000201:enzymology*; D003094:Collagen / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism*; D010974:Platelet Aggregation / Q000187:drug effects*
D000244:Adenosine Diphosphate; D003094:Collagen; D008995:Monoamine Oxidase; D004837:Epinephrine