Outcome of pregnancy after amniocentesis for chromosome analysis.
A consecutive series of 1177 pregnant women examined by amniocentesis for chromosomal abnormalities delivered 1039 live-born babies weighing over 2500 g and 79 live-born babies weighing under 2500 g. Twenty-six abortions were induced (2.2%)--13 (1.1%) because of chromosomal abnormalities--and 28 women (2.4%) aborted spontaneously; in these cases chromosomes were normal. Analysis of all spontaneous abortions in the series suggested that 0.3-0.7% might have resulted from amniocentesis.
D000028:Abortion, Induced; D000022:Abortion, Spontaneous / Q000209:etiology*; D000328:Adult; D000649:Amniocentesis / Q000009:adverse effects*; D002869:Chromosome Aberrations / Q000175:diagnosis; D025063:Chromosome Disorders; D005260:Female; D005313:Fetal Death / Q000209:etiology; D006801:Humans; D007231:Infant, Newborn; D008875:Middle Aged; D011247:Pregnancy