Kinetics of 131 I-o-iodohippurate in rats.
The organ distribution of 131I-o-iodohippurate (OIH) was studied in rats in the time interval of 1--1440 min. The mean decrease of OIH  in plasma was fitted with a function composed of three exponential terms. A three-compartment model describing kinetics of OIH in rats was suggested and its parameters were computed. Comparison of organ and plasma concentrations of OIH showed that the liver, up to 30 min, and the heart and lungs, up to 15 min after administration, form with plasma a common central compartment.
D000818:Animals; D007457:Iodine Radioisotopes; D007465:Iodohippuric Acid / Q000097:blood / Q000378:metabolism*; D008297:Male; D051381:Rats; D013997:Time Factors
D007457:Iodine Radioisotopes; D007465:Iodohippuric Acid