[Epidemiology, clinical data and immune response of an epidemic of hepatitis A (author's transl)].
Almost all members of an affected family (46 persons) were followed up for a year after contracting hepatitis A during an epidemic in a rural area. Sixteen children, one juvenile and a 42-year-old woman had been infected. A mild subclinical course was present in about a third. All but one person in the studied population who were over 25 years had antibody titres from an earlier hepatitis A infection. As result, those who fell ill were almost exclusively children and juveniles with an average age of 15 years. Contagion rate within the family was 56.7% for those not immunised. Antibodies against hepatitis A virus of the IgG class rose in the majority of patients between the sixth and twelfth month of the infection. There was a significant correlation between the titre after one year and maximal GPT and bilirubin levels in the acute phase of the illness.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000410:Alanine Transaminase / Q000097:blood; D000914:Antibodies, Viral / Q000032:analysis; D001663:Bilirubin / Q000097:blood; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks; D005500:Follow-Up Studies; D005860:Germany, West; D006506:Hepatitis A / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D013997:Time Factors
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D000410:Alanine Transaminase; D001663:Bilirubin
Hepatitis A: Epidemiologie, klinische Daten und Immunantwort. Untersuchungen im Rahmen einer örtlich begrenzten Epidemie.