Hyperglycemia associated with the therapeutic use of L-asparaginase: possible role of insulin receptors.
A study of four children, two with acute lymphocytic leukemia and two with non-Hodgkin lymphoma, treated for three days with L-asparaginase, suggests that insulin receptors may be involved in the hyperglycemia associated with the use of L-asparaginase. Comparison of insulin receptors of circulating monocytes revealed a marked decrease in their number after treatment. This might also explain the lack of response to insulin treatment in one of the patients with symptomatic hyperglycemia.
D001215:Asparaginase / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000139:chemically induced*; D007945:Leukemia, Lymphoid / Q000188:drug therapy; D008223:Lymphoma / Q000188:drug therapy; D008297:Male; D009000:Monocytes / Q000648:ultrastructure; D011972:Receptor, Insulin / Q000502:physiology*
D011972:Receptor, Insulin; D001215:Asparaginase