Increase in vivo of unesterified fatty acids, prostaglandin F2 alpha but not thromboxane B2 in rat brain during drug induced convulsions.
The amount of free arachidonic acid and prostaglandin F2 alpha in rat cerebral hemispheres was increased following convulsions induced by carbachol and metrazol. The level of thromboxane B2 was not affected and prostaglandin endoperoxides could only be "trapped" after a very short convulsive period. Unesterified fatty acid levels at 2 minutes post-mortem were decreased by 50% in the cerebral hemispheres of phenytoin treated rats. Under the same conditions, phenobarbital and diazepam had little effect on the levels of free fatty acids in rat brain.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002217:Carbachol / Q000494:pharmacology; D005230:Fatty Acids, Nonesterified / Q000378:metabolism*; D008297:Male; D010433:Pentylenetetrazole / Q000494:pharmacology; D011449:Prostaglandin Endoperoxides / Q000378:metabolism; D011460:Prostaglandins F / Q000378:metabolism*; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000378:metabolism*; D013929:Thromboxane B2 / Q000378:metabolism*; D013931:Thromboxanes / Q000378:metabolism*
D005230:Fatty Acids, Nonesterified; D011449:Prostaglandin Endoperoxides; D011460:Prostaglandins F; D013931:Thromboxanes; D013929:Thromboxane B2; D002217:Carbachol; D010433:Pentylenetetrazole