title: Differential susceptibility of Propionibacterium acnes, P. granulosum and P. avidum to free fatty acids.
abstract: The susceptibility of 98 Propionibacterium acnes, P. granulosum and P. avidum strains isolated from acne cases and appropriate reference strains to decanoic, dodecanoic, octadeca-9,12 dienoic, and octadeca-9,12,15 trienoic acids was investigated using minimal inhibitory concentration estimation by an agar dilution techique. The tested acids showed their relative antibacterial activity in the following order: C18:3 delta 9,12,15 greater than C18:2 delta 9,12 greater than C12:0 greater than C10:0 Differences between minimal inhibitory concentration values for P. acnes, and P. avidum versus P. granulosum strains were demonstrated in the cases of octadeca-9,12 dienoic, and octadeca-9,12,15 trienoic acids.
mesh_terms: D003652:Decanoic Acids / Q000494:pharmacology; D005230:Fatty Acids, Nonesterified / Q000494:pharmacology*; D007850:Lauric Acids / Q000494:pharmacology; D011424:Propionibacterium / Q000187:drug effects*; D011425:Propionibacterium acnes / Q000187:drug effects; D013229:Stearic Acids / Q000494:pharmacology
chemical_list: D003652:Decanoic Acids; D005230:Fatty Acids, Nonesterified; D007850:Lauric Acids; D013229:Stearic Acids