Filtration of circulating particles by splenic autotransplants.
To determine whether filtration in reconstituted perifollicular marginal zones underlies particle sequestration in regenerating spleen transplants, the distribution of IV injected particles of tantalum was examined in autografts freely transplanted into subcutaneous pouches in rats. In two to six weeks old autografts removed one to three hours after particle injection, the reconstituted marginal zones contained practically all of the sequestered tantalum. At 48 hours to 20 weeks following injection, marginal zones were largely free of particles which were distributed extracellularly throughout the red pulp. This sequential pattern of distribution conformed closely to that observed in the intact spleen. The findings indicate that a reconstituted marginal zone allows splenic autotransplants to function as simple mechanical filters. Increased demand for this activity rather than for phagocytosis may be the predominant factor regulating spleen growth.
D000818:Animals; D008297:Male; D051381:Rats; D012038:Regeneration; D013154:Spleen / Q000032:analysis / Q000502:physiology* / Q000637:transplantation; D013635:Tantalum / Q000032:analysis; D014182:Transplantation, Autologous
D013635:Tantalum