Experimental evidence for vasoactive intestinal peptide as the cause of the watery diarrhea syndrome.
We have infused pure porcine vasoactive intestinal peptide (VIP) into 8 healthy ambulant unsedated pigs. At plasma VIP levels closely comparable to those found in the human Verner-Morrison syndrome, gross watery diarrhea and hypokalemia were produced. When the VIP infusion was discontinued the water diarrhea ceased abruptly. This study therefore provides some evidence to implicate VIP as a possible causal agent in the pathogenesis of the human watery diarrhea syndrome.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002118:Calcium / Q000097:blood*; D003967:Diarrhea / Q000097:blood / Q000209:etiology*; D005768:Gastrointestinal Hormones / Q000502:physiology*; D011188:Potassium / Q000097:blood; D012964:Sodium / Q000097:blood; D013552:Swine; D013577:Syndrome; D014660:Vasoactive Intestinal Peptide / Q000502:physiology*
D001786:Blood Glucose; D005768:Gastrointestinal Hormones; D014660:Vasoactive Intestinal Peptide; D012964:Sodium; D011188:Potassium; D002118:Calcium