Methylprednisolone in posttraumatic pulmonary insufficiency.
The effect of methylprednisolone, 30 mg/kg on the musculoskeletal trauma model in dogs were compared with the previously reported untreated models. The atelectasis, inflammation, and alveolar membrane thickening were ameliorated. There was a decrease in the coagulopathy of trauma as well as increased cardiac output, pulmonary vasodilitation and a decrease in the pulmonary shunt. Although these changes are salutory, the majority of patients with posttraumatic pulmonary insufficiency can be adequately treated by prompt adequate volume replacement, blood replacement, and appropriate use of cardiotonic drugs. Only in the resistant patient are steroids necessary.
D000818:Animals; D004285:Dogs; D050723:Fractures, Bone / Q000150:complications* / Q000503:physiopathology; D005596:Fractures, Closed / Q000150:complications; D008171:Lung Diseases / Q000378:metabolism; D008775:Methylprednisolone / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D010101:Oxygen Consumption; D011652:Pulmonary Circulation / Q000187:drug effects; D012128:Respiratory Distress Syndrome / Q000188:drug therapy* / Q000209:etiology; D014655:Vascular Resistance / Q000187:drug effects
D008775:Methylprednisolone