title: Evaluation of tests for the diagnosis of lead exposure in sheep.
abstract: Several laboratory tests that are currently used for the diagnosis of lead poisoning in man were evaluated for the detection of lead poisoning in sheep given 3 or 10 mg Pb/kg body weight/day for 7 weeks. Urinary porphyrins and basophilic stippling of erythrocytes were not sensitive indicators of lead poisoning in sheep, while urinary lead and urinary delta-aminolevulinic acid concentrations were too variable to have diagnostic value. However, erythrocyte delta-aminolevulinic acid dehydratase was strongly inhibited by exposure to relatively low doses of lead, while blood lead concentrations gave an indication of the level of exposure to lead poisoning.
mesh_terms: D000818:Animals; D004796:Clinical Enzyme Tests; D005069:Evaluation Studies as Topic; D007854:Lead / Q000032:analysis; D007855:Lead Poisoning / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D008297:Male; D000623:Porphobilinogen Synthase / Q000097:blood; D012756:Sheep; D012757:Sheep Diseases / Q000175:diagnosis* / Q000473:pathology
chemical_list: D007854:Lead; D000623:Porphobilinogen Synthase