title: Effects of prostaglandins and their methylated analogues upon human adenylate cyclase in the upper gastrointestinal tract.
abstract: The effects of prostaglandin E2, prostaglandin A2 and their methylated analogues upon the adenylate cyclase in human gastric mucosa were studied. PG E2 and 16,16-dimethyl-PG E2 stimulated the enzyme activity to a greater degree than PG A2 and 16,16-dimethyl-PG A2. 16,16-dimethyl-PG E2 was less potent in activating the enzyme system than its parent compound. The results suggest that the more pronounced antisecretory activity of 16,16-dimethyl-PG E2 is due to its greater resistance against enzymatic degradation.
mesh_terms: D000262:Adenylyl Cyclases / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004386:Duodenum / Q000201:enzymology; D005753:Gastric Mucosa / Q000201:enzymology*; D006801:Humans; D007413:Intestinal Mucosa / Q000201:enzymology*; D011454:Prostaglandins A / Q000008:administration & dosage / Q000494:pharmacology*; D011455:Prostaglandins A, Synthetic / Q000008:administration & dosage / Q000494:pharmacology*; D011458:Prostaglandins E / Q000008:administration & dosage / Q000494:pharmacology*; D011459:Prostaglandins E, Synthetic / Q000008:administration & dosage / Q000494:pharmacology*; D011706:Pyloric Antrum / Q000201:enzymology
chemical_list: D011454:Prostaglandins A; D011455:Prostaglandins A, Synthetic; D011458:Prostaglandins E; D011459:Prostaglandins E, Synthetic; D000262:Adenylyl Cyclases