[Effect of proteolytic enzymes on kanamycin pharmacokinetics in experimental suppurative infection].
The effect of the proteolytic enzyme trypsin on kanamycin pharmacokinetics in rats with experimental purulent infection was studied. An increase in the kanamycin serum levels after administration of the drugs in combination was observed as compared to the control. In a dose of 0.03 mg per animal trypsin had no effect on the kanamycin pharmacokinetics in the rats with experimental peritonitis.
D000818:Animals; D001702:Biopharmaceutics; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D007612:Kanamycin / Q000378:metabolism* / Q000627:therapeutic use; D007700:Kinetics; D010538:Peritonitis / Q000188:drug therapy / Q000378:metabolism*; D051381:Rats; D013997:Time Factors; D014357:Trypsin / Q000378:metabolism* / Q000627:therapeutic use
D007612:Kanamycin; D014357:Trypsin
Vliianie proteoliticheskikh fermentov na farmakokinetiku kanamitsina v usloviiakh éksperimental'noĭ gnoĭnoĭ infektsii.