title: The effect of systemic treatment with 5-fluorouracil on the epidermis of the guinea pig.
abstract: The thymidine labelling index and the mitosis rate (blocked by colcemid) in the basal cell layer of the guinea pig were determined before and during treatment with 5-fluorouracil (1 mg i.p. in 2 day's interval/100 g body weight). Additionally, the epidermal area and thickness and the number and size of cells were measured. 5-Fluorouracil equally reduces the thymidine labelling index and the mitosis rate with the full effect after treatment of at least 22 days. From these findings it is concluded that the S-phase--calculated from the end of the thymidine synthesis--is not altered. Furthermore atrophy of the epidermis runs parallel with the reduction of the 3H thymidine labelling index and the mitosis rate.
mesh_terms: D000818:Animals; D001345:Autoradiography; D000078404:Epidermal Cells; D004817:Epidermis / Q000187:drug effects; D005472:Fluorouracil / Q000494:pharmacology*; D006168:Guinea Pigs; D008938:Mitosis / Q000187:drug effects; D012867:Skin / Q000187:drug effects*; D013936:Thymidine
chemical_list: D005472:Fluorouracil; D013936:Thymidine