Activity of derivatives and analogs of dapsone against Mycobacterium leprae.
Of 25 dapsone derivatives and analogs screened for activity against Mycobacterium leprae in the mouse footpad system, only 7 were active. All seven were metabolized to or contaminated with dapsone.
D000818:Animals; D003622:Dapsone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D007918:Leprosy / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C
D003622:Dapsone