title: Mode of action of gentamicin antibiotics produced by Micromonospora purpurea.
abstract: Gentamicin antibiotics were produced fermentatively by Micromonospora purpurea. They were separated into gentamicin C1, C1a and C2 by paper chromatographic technique, using chloroform, methanol, and 17.0% of NH4OH (2: 1: 1 v/v) as developing solvent. The different antibiotics showed variable antimicrobial activities. The gentamicin antibiotics inhibited the biosynthesis of DNA and RNA of the proteins, present in the cells of Staphylococcus aureus.
mesh_terms: D001419:Bacteria / Q000187:drug effects; D004269:DNA, Bacterial / Q000096:biosynthesis; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D005839:Gentamicins / Q000096:biosynthesis / Q000494:pharmacology*; D008847:Micromonospora / Q000378:metabolism*; D010750:Phosphoproteins / Q000096:biosynthesis; D012329:RNA, Bacterial / Q000096:biosynthesis; D013045:Species Specificity; D013211:Staphylococcus aureus / Q000187:drug effects / Q000378:metabolism
chemical_list: D004269:DNA, Bacterial; D005839:Gentamicins; D010750:Phosphoproteins; D012329:RNA, Bacterial