title: Studies on chloride permeability of the skin of Leptodactylus ocellatus: II. Na+ and Cl- effect of inward movements of Cl-.
abstract: At low concentration (1 mM) of Cl- in the outer solution, the influx of chloride through the isolated skin (JCl13) of the South American frog Leptodactylus ocellatus (L.) seems to be carried by two mechanisms: (i) a passive one that exhibits the characteristics of an exchange diffusion process, and (ii) an active penetration. Studies of the influx and efflux of chloride (JCl13 and JCl31) indicate that the presence of a high (107 mM) concentration of Cl- in the outer solution activates the translocation of this ion through the cells. Studies of the unidirectional flux of Cl- across the outer barrier (JCl12) indicate that Na+ out stimulates the penetration of Cl- at this level. Cl- out, in turn, stimulates the JNa12, but this effect is only detected at low concentrations of Na+ out.
mesh_terms: D000818:Animals; D001001:Anura; D001692:Biological Transport; D002463:Cell Membrane Permeability; D002712:Chlorides / Q000378:metabolism* / Q000494:pharmacology; D066298:In Vitro Techniques; D012867:Skin / Q000378:metabolism*; D012964:Sodium / Q000494:pharmacology*
chemical_list: D002712:Chlorides; D012964:Sodium