title: Control of polydipsic drinking by a taste aversion procedure.
abstract: Rats were given daily sessions with free access to food and saccharin flavored water. After fluid consumption had stabilized food was delivered once every minute. Water was always available in the home cage. All rats showed the marked increase in fluid consumption known as schedule-induced polydipsia. The rats were then poisoned with lithium chloride after each of three sessions in an attempt to condition a taste aversion to the saccharin. On recovery from the toxicosis all rats showed first a reduction and then a recovery in saccharin intake. To establish the nature of this effect, the rats were poisoned after saccharin consumption in the home cage. Again there was a marked reduction in polydipsic drinking in the experimental chamber. These results indicate that common incentive mechanisms govern normal and polydipsic drinking and stand in contrast to published results pointing to different drive systems in the brain mediating normal and polydipsic drinking.
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000502:physiology; D002712:Chlorides; D003213:Conditioning, Psychological; D004327:Drinking Behavior / Q000502:physiology; D005260:Female; D008094:Lithium / Q000506:poisoning*; D051381:Rats; D013649:Taste / Q000187:drug effects / Q000502:physiology
chemical_list: D002712:Chlorides; D008094:Lithium