Inhibition of rat hepatic dimethylnitrosamine demethylase by cyclic and acyclic nitrosamines and secondary amines.
Inhibition of hepatic dimethylnitrosamine (DMN) metabolism by a variety of cyclic and acyclic nitrosamines was demonstrated. Nitrosoproline, a noncarcinogenic nitrosamine, behaved differently from the carcinogenic nitrosamines as an inhibitor for DMN-demethylase. Secondary amines corresponding to the nitrosamines inhibited DMN-demethylase in a manner similar to the nitrosamines.
D000818:Animals; D004128:Dimethylnitrosamine; D008099:Liver / Q000201:enzymology*; D008297:Male; D009602:Nitrosamines / Q000494:pharmacology*; D010089:Oxidoreductases, N-Demethylating / Q000037:antagonists & inhibitors*; D011392:Proline / Q000031:analogs & derivatives / Q000494:pharmacology; D051381:Rats
D009602:Nitrosamines; D011392:Proline; D010089:Oxidoreductases, N-Demethylating; C010259:nitrosoproline; D004128:Dimethylnitrosamine