Mutagenicity and carcinogenicity of 8-MOP/UVA in cell cultures.
HGPRT-deficient mutants of chinese hamster cells and human skin fibroblasts are selected with 6-thioguanine after treatment with the combination 8-MOP and UVA. Calculation based on this study indicate that 1.7 X 10(-5) mutants will be induced in the epidermis per session of PUVA therapy. Induction of cell-transformation was observed in C3H and 3T3 mouse cells.
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000139:chemically induced; D002478:Cells, Cultured; D006224:Cricetinae; D006801:Humans; D066298:In Vitro Techniques; D008730:Methoxsalen / Q000009:adverse effects*; D051379:Mice; D009154:Mutation / Q000528:radiation effects; D010778:Photochemotherapy / Q000009:adverse effects*; D014467:Ultraviolet Therapy / Q000009:adverse effects
D008730:Methoxsalen