Cochlear initiation site of the frequency-following response: a study of patients with sensorineural hearing loss.
The cochlear initiation of the frequency-following response (FFR) was assessed by comparing the FFR thresholds to the pure-tone thresholds in four groups of patients suffering from different forms of sensorineural hearing loss. The groups consisted of patients suffering from (1) pure high-frequency hearing losses; (2) high-frequency hearing losses mixed with moderate low-frequency losses; (3) flat hearing losses, and (4)low-frequency hearing losses. Across groups, the pattern of thresholds of the FFR evoked by 500-Hz tome bursts paralleled the pattern of pure-tone thresholds only for the low frequencies- not the high frequencies. In order to clarify the interpretation of this result, a high-pass masking experiment was performed on patients with low-frequency hearing losses. High-pass masking noise did not affect the FFR thresholds to 500-Hz tone burst, but it produced a phase shift of the FFR at stronger intensity levels. The data are interpreted as strongly supporting the view that the FFR at low levels is initiated primarily by activity in the apical portion of the cochlea.
D000161:Acoustic Stimulation; D000293:Adolescent; D000328:Adult; D001299:Audiometry; D001309:Auditory Threshold / Q000502:physiology; D003051:Cochlea / Q000503:physiopathology*; D006319:Hearing Loss, Sensorineural / Q000175:diagnosis / Q000503:physiopathology*; D006801:Humans; D008875:Middle Aged; D010470:Perceptual Masking; D010897:Pitch Discrimination / Q000502:physiology