Synthesis and biological activity of 15-arylprostaglandins.
Prostaglandin analogues in which the alkyl chain attached to C-15 in the natural compounds is replaced by an aryl group have been synthesised. Some of these compounds are potent luteolytic agents and comparisons are drawn between this series and 16-aryloxyprostaglandins.
D000818:Animals; D006224:Cricetinae; D005260:Female; D066298:In Vitro Techniques; D008186:Luteolytic Agents / Q000138:chemical synthesis; D008722:Methods; D011247:Pregnancy; D011465:Prostaglandins, Synthetic / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014590:Uterine Contraction / Q000187:drug effects
D008186:Luteolytic Agents; D011465:Prostaglandins, Synthetic