Evaluation of effect of acetylsalicylic acid using electrical stimulation on the forefinger of healthy volunteers.
1 In order to determine the optimal level of electrical stimulation, the degree of pain sensitivity produced by electrical stimulation on the volar side of terminal phalange of the right forefinger was studied in 22 male and female volunteers between the ages of 20 and 27 years. 2 A stimulation frequency of 400 Hz, width of 0.1 ms and electrical potential of 55 V was found to be optimal for study fo analgesics. 3 The effect of acetylsalicylic acid was studied in 40 healthy male volunteers between the ages of 20 and 25 years. Electrical stimulation was applied for 5 s under a single-blind method at a frequency of 400 Hz, width of 0.1 ms and electrical potential of 25, 35 and 55 V. Placebo, 250 mg, 500 mg and 1 000 mg of acetylsalicyclic acid were administered orally under double-blind method conditions. 4 As a result of this study, it was found that acetslsalicylic acid in a dose of 500 and 1 000 mg, was effective in relieving pain with statistically significant differences from a placebo.
D000328:Adult; D001241:Aspirin / Q000494:pharmacology*; D004311:Double-Blind Method; D004558:Electric Stimulation; D005260:Female; D005385:Fingers / Q000502:physiology; D006801:Humans; D008297:Male; D010146:Pain / Q000503:physiopathology*; D010919:Placebos; D013997:Time Factors
D010919:Placebos; D001241:Aspirin