title: The contrasting effects of enflurane on transplacental exchange after methohexitone and ketamine induction of anaesthesia for caesarean section.
abstract: Supplementation of general anaesthesia with enflurane 0.6% before delivery of the foetus by elective Caesarean section, produced contrasting effects after methohexitone and ketamine administration. Enflurane, an inhalational agent causing vasodilation and uterine relaxation, enhanced maternal to foetal transplacental exchange following methohexitone induction of narcosis. This beneficial effect of the volatile agent was not seen after ketamine, a vasoconstrictor drug which stimulates myometrial contraction.
mesh_terms: D000328:Adult; D000773:Anesthesia, Obstetrical; D001784:Blood Gas Analysis; D002585:Cesarean Section; D004347:Drug Interactions; D004737:Enflurane / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007649:Ketamine / Q000494:pharmacology*; D008431:Maternal-Fetal Exchange / Q000187:drug effects*; D008723:Methohexital / Q000494:pharmacology*; D008738:Methyl Ethers / Q000494:pharmacology*; D011247:Pregnancy
chemical_list: D008738:Methyl Ethers; D007649:Ketamine; D004737:Enflurane; D008723:Methohexital