Modification of the tuberculin reaction by levan.
High molecular levan (polyfructoside) inhibits the skin tuberculin reaction in guinea pigs as judged by the degree of induration and erythema. The effect is dose-dependent. No effect on cellular infiltration was observed in histological studies. The lymph nodes of levan-treated animals were smaller and exhibited a much milder granulomatous reaction than those of non-treated animals.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D005620:Freund's Adjuvant; D005630:Fructans / Q000494:pharmacology*; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000473:pathology*; D008198:Lymph Nodes / Q000187:drug effects / Q000473:pathology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011134:Polysaccharides / Q000494:pharmacology*; D013154:Spleen / Q000187:drug effects; D014374:Tuberculin Test
D005630:Fructans; D011134:Polysaccharides; D005620:Freund's Adjuvant