title: Differences in the availability of d- and l-enantiomers after administration of racemic amphetamine to rats.
abstract: 1. Rats were treated with racemic amphetamine or separately with the single enantiomers. The two optical isomers were determined in several brain areas, in plasma and urine. 2. The concentration of d-enantiomer significantly exceeds that of the l-enantiomer in brain and plasma but not in urine, following administration of racemic amphetamine. In contrast, when the two isomers are given separately, their brain concentrations are similar. 3. Such a difference does not appear in the brain of mice treated with racemic amphetamine or in the brain of rats pre-treated with SKF 525-A, an inhibitor of amphetamine hydroxylation. 4. The possibility that the l-isomer can interfere with hydroxylation of d-amphetamine is discussed.
mesh_terms: D000661:Amphetamine / Q000378:metabolism*; D000818:Animals; D001682:Biological Availability; D001921:Brain / Q000378:metabolism; D003913:Dextroamphetamine / Q000378:metabolism*; D005260:Female; D006900:Hydroxylation; D051379:Mice; D011335:Proadifen / Q000494:pharmacology; D051381:Rats; D013237:Stereoisomerism; D013997:Time Factors
chemical_list: D011335:Proadifen; D000661:Amphetamine; D003913:Dextroamphetamine