title: Circulating anticoagulant associated with chronic active hepatitis.
abstract: Chronic active hepatitis is frequently associated with a variety of serologic abnormalities. A patient with chronic active hepatitis and a circulating anticoagulant to factors XI and XII is described. Circulating anticoagulants should be suspected in patients with chronic active hepatitis and a prolonged partial thromboplastin time. This risk of liver biopsy in these patients is unknown, but this possible hazard should be considered in all patients with chronic active hepatitis.
mesh_terms: D000328:Adult; D001706:Biopsy; D001777:Blood Coagulation; D001780:Blood Coagulation Tests; D002908:Chronic Disease; D005172:Factor XI / Q000037:antagonists & inhibitors; D005174:Factor XII / Q000037:antagonists & inhibitors; D005260:Female; D006505:Hepatitis / Q000097:blood*; D006801:Humans; D008099:Liver / Q000473:pathology; D012306:Risk
chemical_list: D005174:Factor XII; D005172:Factor XI