title: Local anaesthetic activity of some sec-amino-N-(aryl-aralkyl)-ethyl acetamides.
abstract: Six basic amides were screened for local anaesthetic activity and compared with procaine and lignocaine. Amongst the basic amides screened, piperidino-N-(alpha-4-ethoxy phenyl- beta-phenyl) ethyl and Diethylamino-N (alpha-4-ethoxy- beta-phenyl) ethyl acetamide were found to be more effective as compared to lignocaine. They were found to be non-irritant, and non-toxic even in high doses.
mesh_terms: D000081:Acetamides / Q000494:pharmacology* / Q000633:toxicity; D000779:Anesthetics, Local; D000818:Animals; D006168:Guinea Pigs; D007928:Lethal Dose 50; D008012:Lidocaine / Q000494:pharmacology; D011343:Procaine / Q000494:pharmacology; D011817:Rabbits
chemical_list: D000081:Acetamides; D000779:Anesthetics, Local; D011343:Procaine; D008012:Lidocaine