HLA and thyrotoxicosis (Graves' disease) in Chinese.
HLA locus A and B typing was performed on 86 Chinese thyrotoxicosis (Graves' Disease) patients and 238 normal Chinese subjects. The frequency of HLA-Bw46 (Sin 2) was found to be significantly higher among the patients than controls (x2 = 26.15, corrected P less than .003, relative risk = 3.74). The risk associated with Bw46 was reflected in the Bw46 heterozygotes. The relative risks of the joint occurrence of Bw46/B40 and Bw46/B13 were 8.74 and 5.88 respectively.
D002681:China; D005260:Female; D005787:Gene Frequency; D006680:HLA Antigens; D006579:Heterozygote; D006650:Histocompatibility Testing; D006720:Homozygote; D006801:Humans; D006980:Hyperthyroidism / Q000276:immunology*; D008297:Male
D006680:HLA Antigens