Topical retinoic acid in the treatment of corneal xerophthalmia.
Eight children with corneal xerophthalmia (x2 or x3A) received standard high-protein diets and massive systemic vitamin A therapy. Retinoic acid, 0.1% in oil, was applied daily to one eye, and oil alone to the other. Topical retinoic acid proved safe and effective in speeding corneal healing, especially during the first critical days.
D000287:Administration, Topical; D000818:Animals; D002648:Child; D002675:Child, Preschool; D004044:Dietary Proteins / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D051381:Rats; D014212:Tretinoin / Q000627:therapeutic use*; D014801:Vitamin A / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014802:Vitamin A Deficiency / Q000178:diet therapy / Q000188:drug therapy*; D014985:Xerophthalmia / Q000178:diet therapy / Q000188:drug therapy*
D004044:Dietary Proteins; D014801:Vitamin A; D014212:Tretinoin