Immunomodulating effects of BM 12.531 in animals and tolerance in man.
BM 12.531, a 2-cyansubstituted aziridine, has interesting therapeutic and immunomodulating effects. Antitumor effects in Meth A sarcoma in mice and an increase in resistance to Candida albicans infection in mice have been found. It was demonstrated that BM 12.531 can modulate the immune system in animals (DTH lymphocyte transformation, etc). It was also shown that BM 12.531 can restore the immune response in animals, where this has been suppressed by cyclophosphamide. In a phase I study in cancer patients it was demonstrated that BM 12.531 is very well-tolerated. A dose-dependent increase was found in the percentage of spontaneous T lymphocytes in cancer patients after the administration of BM 12.531.
D000818:Animals; D001388:Aziridines / Q000494:pharmacology*; D001389:Azirines / Q000494:pharmacology*; D003520:Cyclophosphamide / Q000008:administration & dosage; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D007109:Immunity / Q000187:drug effects*; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007970:Leukopenia / Q000517:prevention & control; D008213:Lymphocyte Activation / Q000187:drug effects; D008264:Macrophages / Q000276:immunology; D008297:Male; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy*; D051381:Rats; D012513:Sarcoma, Experimental / Q000188:drug therapy
D001388:Aziridines; D001389:Azirines; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide