Action of cefoxitin and cefamandole on human neutrophil function.
Polymorphonuclear neutrophilic leukocyte chemotaxis was examined in vitro in the presence to two new antibiotics: cefamandole and cefoxitin. Results indicate that cefamandole inhibited neutrophil chemotaxis to a significant degree only at high antibiotic concentrations of 100 microgram/ml (P less than 0.01) and has no significant effect at normal serum therapeutic range. Cefoxitin was found to produce a 43% inhibition (P less than 0.01) of human in vivo neutrophil chemotaxis at antibiotic concentrations of 100 microgram/ml and have a minimal inhibitory effect (1 approximately 9%) at low concentrations (1 approximately 5 microgram/ml). Both cefamandole and cefoxitin had no significant effect on opsonophagocytosis.
D002435:Cefamandole / Q000494:pharmacology*; D002440:Cefoxitin / Q000494:pharmacology*; D002511:Cephalosporins / Q000494:pharmacology*; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D009504:Neutrophils / Q000187:drug effects*; D009895:Opsonin Proteins / Q000502:physiology; D010587:Phagocytosis / Q000187:drug effects
D002511:Cephalosporins; D009895:Opsonin Proteins; D002435:Cefamandole; D002440:Cefoxitin