title: Ritalin, Benzedrine and Dexedrine do not transform F 1706 rat cells.
abstract: Ritalin (methylphenidate hydrochloride), Benzedrine (amphetamine sulfate), and Dexedrine (dextroamphetamine sulfate) were examined for oncogenicity using a serial line of Fischer rat embryo cells, which was previously shown to be a sensitive and accurate indicator of chemicals carcinogenic for rodents. At the concentrations tested, none of the 3 drugs induced transformation in Fischer rat embryo cells.
mesh_terms: D000661:Amphetamine / Q000633:toxicity*; D000818:Animals; D002273:Carcinogens; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D003913:Dextroamphetamine / Q000633:toxicity*; D008774:Methylphenidate / Q000633:toxicity*; D051381:Rats
chemical_list: D002273:Carcinogens; D008774:Methylphenidate; D000661:Amphetamine; D003913:Dextroamphetamine