Effect of streptozotocin diabetes and insulin administration on some liver enzyme activities in the post-weaning rat.
Streptozotocin-induced diabetes suppressed the normal development of the nine glycolytic and lipogenic enzyme activities measured. With the exception of NADP-isocitrate dehydrogenase, insulin replacement therapy induced increased activities of the enzymes in streptozotocin-treated rats. Insulin appeared to have a specific effect on the activities of glucokinase, ATP-citrate lyase, malic enzyme, and glucose-6-P-dehydrogenase.
D000367:Age Factors; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000378:metabolism*; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D006019:Glycolysis; D007328:Insulin / Q000494:pharmacology*; D008055:Lipids / Q000096:biosynthesis; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D051381:Rats
D007328:Insulin; D008055:Lipids