[Effect of an estrogen-progestin contraceptive preparation on the enzymatic acitivity of the pentosephosphate carbohydrate metabolic pathway and nucleic acid metabolic indices].
The effect of a long-term (14 days) combined introduction of mestranol and noiethinodrel in contraceptive doses on the activity of pentosophosphate routes enzymes of the carbohydrates metabolism, that of acid and basic ribonucleases and on the level of summary nucleinic acids in the uterus and liver in sexually mature female-rats was studied. It was found that the concentration of summary nucleinic acids in the tissues increases under the effect of the drug, the oxidative reactions enzymes become more active, while the activity of non-oxidative reactions enzymes of the pentosophosphate route and of acid and basic endoribonucleases in inhibited.
D000818:Animals; D050260:Carbohydrate Metabolism; D003276:Contraceptives, Oral; D003277:Contraceptives, Oral, Combined; D004789:Enzyme Activation / Q000187:drug effects; D005260:Female; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008656:Mestranol / Q000494:pharmacology*; D009641:Norethynodrel / Q000494:pharmacology*; D009696:Nucleic Acids / Q000378:metabolism*; D010428:Pentosephosphates / Q000378:metabolism*; D051381:Rats; D012260:Ribonucleases / Q000378:metabolism; D014599:Uterus / Q000187:drug effects / Q000201:enzymology
D003276:Contraceptives, Oral; D003277:Contraceptives, Oral, Combined; D009696:Nucleic Acids; D010428:Pentosephosphates; D009641:Norethynodrel; D008656:Mestranol; D012260:Ribonucleases
Vliianie éstrogen-progestinovogo kontratseptivnogo preparata na aktivnost' fermentov pentozofosfatnogo puti metabolizma uglevodov i nekotorye pokazateli nukleinovogo obmena.