title: Effect of human leukocyte interferon on the permeability of the cytoplasma membrane of cultured cells.
abstract: The effect of human leukocyte interferon on the cytoplasma membrane of cultured homologous cells has been investigated. U-amnion cells were labelled with (1-14C) alpha-aminoisobutyric acid (AIB), a low-molecular-weight non-metabolizable amino acid. Following uptake, the AIB is released spontaneously from the cells. Treatment of cells with interferon reduced the AIB release. This effect was dosedependent, was neutralized by anti-interferon serum and was strongly reduced by trypsin treatment.
mesh_terms: D000621:Aminoisobutyric Acids / Q000378:metabolism; D000650:Amnion / Q000166:cytology; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002463:Cell Membrane Permeability / Q000187:drug effects*; D002478:Cells, Cultured; D006801:Humans; D007372:Interferons / Q000494:pharmacology*; D007962:Leukocytes
chemical_list: D000621:Aminoisobutyric Acids; D007372:Interferons