Anion inhibitor-sensitive unidirectional sodium movements in the human erythrocyte.
The increased unidirectional sodium influx found when human erythrocytes are suspended in isotonic salt solutions containing bicarbonate ions as a replacement for chloride ions was examined. The increased sodium movement appears to have the transport characteristics of anion movement. Inhibitors of anion transport such as furosemide, fluorodinitrobenzene (FDNB), and 4-acetamido-4'-isothiocyano-stilbene-2-2'-disulfonic acid (SITS) drastically inhibit these augmented sodium movements. An ion-pair mechanism appears to phenomenologically describe much of the data. A possible role for carbamino groups is considered. Such a model, however, required additional assumptions to explain the selectivity and the anion inhibitor effects.
D000838:Anions / Q000037:antagonists & inhibitors; D001639:Bicarbonates / Q000378:metabolism*; D001693:Biological Transport, Active / Q000187:drug effects; D004139:Dinitrofluorobenzene / Q000494:pharmacology; D004912:Erythrocytes / Q000378:metabolism*; D005665:Furosemide / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D008433:Mathematics; D008954:Models, Biological; D012964:Sodium / Q000378:metabolism*; D013267:Stilbenes / Q000494:pharmacology
D000838:Anions; D001639:Bicarbonates; D013267:Stilbenes; D005665:Furosemide; D012964:Sodium; D004139:Dinitrofluorobenzene