title: Effect of urinary bladder distension on renal blood flow, blood pressure and plasma renin activity.
abstract: The effects of urinary bladder distension on renal blood flow, blood pressure and plasma renin activity (PRA) were studied in 50 mongrel dogs anesthetized with chloralose. The dogs were divided into three groups. Group I was composed of dogs intact except for having undergone the surgical procedure for measurement and instillation of 0.9% saline to the bladders. Group II was composed of dogs whose bilateral ureters had been cut. Group III was composed of anephric dogs. Renal blood flow showed reduction during bladder distension in Group I and Group II. This reduction was produced not only by hydraulic mechanisms through the ureters during bladder distension, because the reduction was also observed in the dogs whose ureters had been cut. The rise in blood pressure and increase in PRA were observed in Group I and Group II, while the anephric dogs showed the rise in blood pressure during bladder distension despite the absence of PRA. Therefore, it appeared that the renin-angiotensin system did not directly relate to the rise in blood pressure during bladder distension.
mesh_terms: D000818:Animals; D001794:Blood Pressure; D004108:Dilatation, Pathologic; D004285:Dogs; D007668:Kidney / Q000098:blood supply*; D012039:Regional Blood Flow; D012083:Renin / Q000097:blood*; D001743:Urinary Bladder / Q000503:physiopathology*
chemical_list: D012083:Renin