[Kinetics of cell proliferation in regenerating rat liver following subtotal resection].
Partial (78--80%) hepatectomy was conducted in male rats. The maximal mitotic activity of hepatocytes was seen 38--48 hours after the operation. It was found with thymidine-3H (pulse label) that the G2 period lasted 6 hours and the minimal duration of the S-period was 6 hours. During the liver regeneration after its subtotal resection there was asynchronization of the hepatocyte entrance into the S-period and mitosis, and cell retardation in the G1-and G2-periods. The mentioned changes in the hepatocyte proliferation are the results of intracellular metabolism disturbance under conditions of an excessive functional requirement.
D000818:Animals; D002453:Cell Cycle; D006498:Hepatectomy; D007700:Kinetics; D008099:Liver / Q000166:cytology*; D008115:Liver Regeneration; D008297:Male; D008938:Mitosis; D051381:Rats
Kinetika kletochnoĭ proliferatsii v regeneriruiushcheĭ pecheni krys posle subtotal'noĭ rezektsii.