Angiotensin II mediation of adrenal catecholamine secretion induced by intrarenal isoprenaline infusion.
Isoprenaline infusion into the renal artery of the cat induced an increase in the catecholamine (CA) secretion rate from the adrenal gland. CA release by isoprenaline was preferentially noradrenaline. Intravenous infusion of an angiotensin II (A II) antagonist abolished adrenal CA response to intrarenal isoprenaline injection. It is suggested that intrarenal isoprenaline infusion stimulates renal renin release and A II production which, in turn, stimulates adrenal CA secretion.
D000311:Adrenal Glands / Q000187:drug effects / Q000378:metabolism*; D000804:Angiotensin II / Q000502:physiology*; D000818:Animals; D002395:Catecholamines / Q000378:metabolism*; D002415:Cats; D007261:Infusions, Intra-Arterial; D007545:Isoproterenol / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D012077:Renal Artery; D012504:Saralasin / Q000494:pharmacology
D002395:Catecholamines; D000804:Angiotensin II; D012504:Saralasin; D007545:Isoproterenol