title: Effect of garlic on human platelet aggregation in vitro.
abstract: In 6 healthy adults the effect of essential oil of garlic on platelet aggregation was studied in vitro with an aggreganometer. The blood was collected in a siliconized centrifuge tube containing sodium citrate. The aggregating agents used were ADP, epinephrine and collagen. In each subject aggregation was studied 3 times: (i) initial fasting control; (ii) immediately after (i) but with essential oil of garlic drawn into the syringe together with the sodium citrate; (iii) 5 days after feeding 0.5 mg of essential oil of garlic daily. Addition of essential oil of garlic inhibited in-vitro platelet aggregation induced by ADP, epinephrine or collagen; the effect was dose-related. Oral administration of garlic also decreased platelet aggregation. Thus, garlic seems to inhibit some aspects of thrombus formation.
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology; D000328:Adult; D003094:Collagen / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D005737:Garlic; D006801:Humans; D008875:Middle Aged; D010946:Plants, Medicinal; D010974:Platelet Aggregation
chemical_list: D000244:Adenosine Diphosphate; D003094:Collagen; D004837:Epinephrine