Quantitative determination of thiazides in urine by a sensitive colorimetric method.
Chloriothiazide and hydrochlorothiazide may be determined in urine by the Bratton-Marshall reaction after extracting with ethyl acetate and treating the extract with Florisil. Such treatment reduces the background color of the urine sample and eliminates interferences. The modified procedure is thus sensitive enough to determine both drugs in 24 hour urine specimens from patients receiving therapeutic doses orally.
D002740:Chlorothiazide / Q000627:therapeutic use / Q000652:urine*; D003124:Colorimetry / Q000379:methods; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use / Q000652:urine*; D006868:Hydrolysis
D006852:Hydrochlorothiazide; D002740:Chlorothiazide