Pharmacokinetics of oral cephalosporins: cephradine cephalexin.
A crossover experiment was utilized to compare the pharmacokinetics of a 1-g dose of cephalexin tablets, cephalexin capsules, or cephradine capsules in nine normal human volunteers. These antibiotics were administered as three formulations: two 500-mg capsulin every 6 hr for five doses, and one 1000-mg tablet of cephalexin every 6 hr for five doses. Pharmacokinetic parameters in the experimental groups showed no statistical differences (p greater than 0.1), indicating that these drugs are equivalent pharmacokinetically.
D000284:Administration, Oral; D000328:Adult; D002214:Capsules; D002506:Cephalexin / Q000008:administration & dosage / Q000378:metabolism*; D002511:Cephalosporins / Q000378:metabolism*; D002515:Cephradine / Q000008:administration & dosage / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D013607:Tablets
D002214:Capsules; D002511:Cephalosporins; D013607:Tablets; D002515:Cephradine; D002506:Cephalexin