[Effect of adrenaline, noradrenaline, histamine and acetylcholine on the blood flow in the vascular bed of the bone marrow].
Medullary circulation in the tibia and effect produced on it by microinjections of epinephrine (1.4.10(-5) and 2.7.10(-5) M), norepinephrine (0.2.10(-4) M), histamine (0.9.10(-4) and 1.8.10(-4) M) and acetylcholine (2.2.10(-4) were studies in acute tests on Wistar rats by using the 133Xe clearance method. The study agents significantly changed the circulation rate in the medullary vascular bed. Phasic changes of hemodynamics in the bone marrow occurring under the effect of the mentioned vasoactive substances point to the presence of alpha- and beta-adrenoreceptors and H1- and H2-receptors in the medullary vascular bed.
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D001853:Bone Marrow / Q000098:blood supply* / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000494:pharmacology*; D006632:Histamine / Q000494:pharmacology*; D008657:Metabolic Clearance Rate; D009638:Norepinephrine / Q000494:pharmacology*; D051381:Rats; D012039:Regional Blood Flow / Q000187:drug effects; D013977:Tibia / Q000098:blood supply / Q000187:drug effects; D013997:Time Factors
D006632:Histamine; D000109:Acetylcholine; D009638:Norepinephrine; D004837:Epinephrine
Vliianie adrenalina, noradrenalina, gistamina i atsetilkholina na krovotok v sosudistom lozhe kostnogo mozga.