Ampicillin penetration into the rabbit eye.
Distribution of intravenously injected ampicillin of 50 mg/kg was studied in the rabbit eye using radioactive tracer method. Antibiotic concentration regarded as therapeutic in the treatment of gram-negative organisms was obtained in all vascularized ocular structures. Intermediate values were measured from the cornea and aqueous humour. In the vitreous body and lens, ampicillin was unable to approach a concentration that would be effective against the common gram-negative organisms. The low ampicillin concentration in the vitreous body and lens was unchanged by systemically administered probenecid, which in other parts of the eye caused significantly higher ampicillin levels.
D000667:Ampicillin / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D000818:Animals; D005260:Female; D007275:Injections, Intravenous; D008297:Male; D011817:Rabbits
D000667:Ampicillin