[Effects of various drugs on the lipolytic actions caused by catecholamines and methylxanthine derivatives in white adipose tissues. 1. Effects of procaine and xylocaine (author's transl)].
Effects of procaine and xylocaine on the lipolytic actions caused by catecholamines and methylxanthine derivatives in white adipose tissues from rats were investigated. Both procaine and xylocaine remarkably inhibited the lipolyses caused by norepinephrine, epinephrine, caffeine and theophylline. Xylocaine inhibited the lipolysis more strongly than procaine, and also inhibited the basal lipolysis. The inhibition by either procaine or xylocaine appeared 60 minutes after the addition of the norepinephrine-induced lipolytic action. The antilipolytic action of procaine was evident in medium containing 2 mM EDTA instead of Ca2+, and its antilipolytic action was accelerated by increasing Ca2+ concentration in the medium. From these positive results, we suggest that both procaine and xylocaine have an antilipolytic effect, and this effect is closely dependent on the Ca2+ concentration in the medium.
D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D002118:Calcium / Q000502:physiology; D002395:Catecholamines / Q000037:antagonists & inhibitors*; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D008012:Lidocaine / Q000494:pharmacology*; D050356:Lipid Metabolism; D008297:Male; D009638:Norepinephrine / Q000037:antagonists & inhibitors; D011343:Procaine / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors; D014970:Xanthines / Q000037:antagonists & inhibitors
D002395:Catecholamines; D014970:Xanthines; D011343:Procaine; D008012:Lidocaine; D002118:Calcium; D009638:Norepinephrine