Influence of micrococcus, BCG and related polysaccharides on the proliferation of the L1210 leukaemia.
A comparative study of the effects of BCG, Micrococcus lysodeikticus, and a series of structurally related polysaccharides (complement triggers) on the non-specific and specific immune resistance against L1210 lymphoid leukaemia was carried out and commented on. In contrast with authors of earlier reports, we were unable to generate any effective non-specific or specific immunotherapy after the graft of 10(4) leukaemic cells to 8--10-week-old CDF1 mice. However, when mice were prevaccinated with irradiated (8 krad X-rays) cultured cells combined with 1 mg of bacterium or polysaccharide one month before grafting 10(4) cells, they were given an immunoprotection that was more pronounced with the i.p. than with the i.v. route. Prevaccinated mice were afforded a stronger immunoprotection when boosted repeatedly with 1mg injections of bacterium or polysaccharide after tumour challenge.
D000818:Animals; D000912:Antibodies, Neoplasm / Q000096:biosynthesis; D000942:Antigens, Bacterial; D001500:BCG Vaccine / Q000627:therapeutic use*; D005260:Female; D007939:Leukemia L1210 / Q000276:immunology / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008837:Micrococcus / Q000276:immunology*; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D014611:Vaccination
D000912:Antibodies, Neoplasm; D000942:Antigens, Bacterial; D001500:BCG Vaccine; D011135:Polysaccharides, Bacterial