Synthesis, radiotechnetium labelling, and comparison of biologic behavior of longer-chain analogs of methylene diphosphonate.
Polymethylene diphosphonic acids of different chain lengths ( n = 2, 3, and 10) were synthesized and labeled with technetium-99m. Their biologic behavior was compared with that of Tc-99m-labeled methylene diphosphonate (MDP) in experimental animals. With n = 2 (ethylene diphosphonic acid), the compound resembled MDP in bone affinity. The longer-chain analogs had lower bone affinity.
D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D004164:Diphosphonates / Q000138:chemical synthesis* / Q000378:metabolism; D007553:Isotope Labeling / Q000379:methods*; D051379:Mice; D011817:Rabbits; D013329:Structure-Activity Relationship; D013667:Technetium; D014018:Tissue Distribution
D004164:Diphosphonates; D013667:Technetium