Inhibition of harmaline induced tremors by 16 (S)-16-methyl PGE2 in different mammalian species: a correlation with central cyclic nucleotides and prostaglandins.
Harmaline, an alcaloid of Paganum Armala, induces tremors of central origin and increases cerebellar cGMP without affecting cortical and cerebellar prostaglandin levels. 16(S)-16-methyl PGE2 protects the animals against the seizures induced by the alcaloid and prevents the concomitant rise in cerebellar cGMP. Experiment performed in cats and limited to pharmacological observations, confirmed that, the PGE2 derivative, is a powerful antitremorogenic agent at doses that are devoid of appreciable side effects.
D000470:Alkaloids / Q000037:antagonists & inhibitors*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002415:Cats; D002531:Cerebellum / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism; D006246:Harmaline / Q000037:antagonists & inhibitors*; D008297:Male; D009712:Nucleotides, Cyclic / Q000378:metabolism*; D011453:Prostaglandins / Q000378:metabolism*; D011458:Prostaglandins E / Q000378:metabolism; D011459:Prostaglandins E, Synthetic / Q000494:pharmacology*; D011460:Prostaglandins F / Q000378:metabolism; D051381:Rats; D014202:Tremor / Q000139:chemically induced / Q000378:metabolism / Q000503:physiopathology*
D000470:Alkaloids; D009712:Nucleotides, Cyclic; D011453:Prostaglandins; D011458:Prostaglandins E; D011459:Prostaglandins E, Synthetic; D011460:Prostaglandins F; D006246:Harmaline