Fatal long-term sequela following radiation "cure" for ependymoma.
There are no previous reports of glioblastoma occurring following central nervous system irradiation. This report describes a young girl with an ependymoma at age 13 months who was treated by radiotherapy following surgical removal. At age 6 years she presented with a new lesion in the same location. Histologically there was no evidence of recurrent ependymoma. Instead, the pathological picture suggested glioblastoma or a severe radiation-induced encephalopathy. In either case, it seems likely that the changes were radiation induced.
D001921:Brain / Q000528:radiation effects*; D001932:Brain Neoplasms / Q000209:etiology* / Q000473:pathology / Q000532:radiotherapy; D002648:Child; D004806:Ependymoma / Q000532:radiotherapy*; D005260:Female; D005910:Glioma / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007223:Infant; D009381:Neoplasms, Radiation-Induced / Q000473:pathology*; D011878:Radiotherapy / Q000009:adverse effects*