Cimetidine inhibits burn edema formation.
Large doses of cimetidine significantly inhibit edema formation in thermally injured rat skeletal muscle. Tissue sodium influx and potassium efflux is also sharply restricted. These effects were obtained even if the administration of cimetidine was delayed for up to 4 hours after injury, but no beneficial effect occurred if drug administration was delayed for 14 hours, when most of the edema had already accumulated. The minimal effective dose is between 0.1 to 0.2 mg/gm.
D000818:Animals; D002056:Burns / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D002927:Cimetidine / Q000008:administration & dosage / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D006146:Guanidines / Q000627:therapeutic use*; D011188:Potassium / Q000378:metabolism; D051381:Rats; D012964:Sodium / Q000378:metabolism; D014882:Water-Electrolyte Balance
D006146:Guanidines; D002927:Cimetidine; D012964:Sodium; D011188:Potassium