title: Metabolism of 17beta-hydroxy-2-hydroxymethylene-5alpha-androstan-3-one in the rabbit.
abstract: An acidic metabolite, 2alpha-carboxy-5alpha-androstane-3alpha,16alpha,17alpha-triol and two neutral metabolites, 2alpha-hydroxymethyl-5alpha-androstane-3alpha,17alpha-diol, and 2alpha-hydroxymethyl-5alpha-androstane-3alpha,16alpha,17alpha-triol have been identified in the urine of rabbits orally dosed with 17beta-hydroxy-2-hydroxymethylene-5alpha-androstan-3-one. 2alpha-Hydroxymethyl-5alpha-androstane-3alpha,16alpha,17alpha-triol was previously obtained from the urine of rabbits dosed with 17beta-hydroxy-2alpha-methyl-5alpha-androstan-3-one. The acidic metabolite was the major urinary excretion product.
mesh_terms: D000818:Animals; D001711:Biotransformation; D002849:Chromatography, Gas; D008297:Male; D013058:Mass Spectrometry; D010110:Oxymetholone / Q000031:analogs & derivatives* / Q000378:metabolism; D011817:Rabbits
chemical_list: D010110:Oxymetholone