title: Preliminary studies of the kinetics of citalopram in man.
abstract: The plasma concentrations of citalopram, a potent serotonin reuptake inhibitor, and its demethylated metabolite have been determined by a specific fluorescence coupling technique during single dose experiments in volunteers and in clinical tests. Citalopram was found to have linear kinetics within the dose range investigated, which were characterized by fairly rapid absorption and slow elimination (biological half-life 1--21/2 days). Steady state levels in the range 120--340 nM (i.e. slightly above those associated with pharmacodynamic activity in animals) were attained within a week. A drug/metabolite ratio of 2--3 was recorded.
mesh_terms: D000328:Adult; D001572:Benzofurans / Q000008:administration & dosage / Q000378:metabolism*; D003640:Dealkylation; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009570:Nitriles / Q000008:administration & dosage / Q000378:metabolism*; D011437:Propylamines / Q000008:administration & dosage / Q000378:metabolism*; D012702:Serotonin Antagonists / Q000008:administration & dosage / Q000378:metabolism*; D013997:Time Factors
chemical_list: D001572:Benzofurans; D009570:Nitriles; D011437:Propylamines; D012702:Serotonin Antagonists