title: R-factor mediated trimethoprim resistance: result of two three-month clinical surveys.
abstract: All urinary tract isolates were monitored in the Whittington Hospital, London for trimethoprim resistance over a three-month period in 1975; this survey was repeated 18 months later in 1977. In the later survey the incidence of trimethoprim resistance had increased significantly, and the proportion of strains carrying R-factors conferring trimethoprim resistance had nearly doubled. The pattern of resistances associated with R-factor trimethoprim resistance also changed betweeen these two surveys.
mesh_terms: D001419:Bacteria / Q000187:drug effects; D001437:Bacteriuria; D004352:Drug Resistance, Microbial; D006801:Humans; D011815:R Factors; D013997:Time Factors; D014295:Trimethoprim / Q000494:pharmacology*
chemical_list: D014295:Trimethoprim