Prostaglandin F2alpha induced termination of pregnancy and its reversal by prolactin or progesterone in rats.
Intrauterine insertion of a Silastic-PVP tube containing 400 microgram PGF2alpha terminated midterm pregnancy in 100 per cent of the animals. Progesterone (2 mg/day) or prolactin (PRL) reversed the abortifacient effect of PGF2alpha. A dose- and duration-related effect of the PRL on PGF2alpha induced termination of pregnancy was evident. The results suggest that PGF2alpha and PRL are antagonistic to each other and multiple doses of PRL are needed to neutralize the luteolytic action of PGF2alpha.
D000019:Abortifacient Agents; D000020:Abortifacient Agents, Nonsteroidal; D000818:Animals; D003692:Delayed-Action Preparations; D005260:Female; D005865:Gestational Age; D011247:Pregnancy; D011374:Progesterone / Q000494:pharmacology*; D011388:Prolactin / Q000494:pharmacology*; D011460:Prostaglandins F / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats; D014599:Uterus
D000019:Abortifacient Agents; D000020:Abortifacient Agents, Nonsteroidal; D003692:Delayed-Action Preparations; D011460:Prostaglandins F; D011374:Progesterone; D011388:Prolactin