Arterial hypertension induced by femoral lengthening. A canine model.
In a canine experimental model, femora were lengthened 2.5 to 3.0 centimeters over a one-minute period. Systolic blood-pressure elevation averaged forty millimeters of mercury and diastolic blood-pressure elevation, twenty-two millimeters of mercury. The average peak arterial pressure was 193/115 millimeters of mercury. The effects of sympatholytic agents on the experimental model were tested. Alpha-adrenergic blockade by phenoxybenzamine, total-body catecholamine depletion by reserpine, and sympathetic ganglionic blockade by trimethaphan camphorsulfonate all inhibited the rise in arterial pressure, but beta-adrenergic blockade by propranolol did not. A differential spinal anesthetic with Xylocaine solution dramatically decreased the elevation in arterial pressure.
D000775:Anesthesia, Spinal; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001852:Bone Lengthening / Q000009:adverse effects*; D004195:Disease Models, Animal; D004285:Dogs; D005269:Femur / Q000098:blood supply / Q000601:surgery*; D006973:Hypertension / Q000209:etiology*; D008012:Lidocaine / Q000494:pharmacology; D010643:Phenoxybenzamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D012110:Reserpine / Q000494:pharmacology; D012584:Sciatic Nerve / Q000502:physiology; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000503:physiopathology; D014294:Trimethaphan / Q000494:pharmacology
D010643:Phenoxybenzamine; D014294:Trimethaphan; D012110:Reserpine; D008012:Lidocaine; D011433:Propranolol