title: Bronchial hyperreactivity in cystic fibrosis and asthma.
abstract: We studied 113 patients with CF and compared their responsiveness to inhaled methacholine to that of 50 asthmatic children and 26 normal children. Positive responses to MCh occurred in 51% of the patients with CF and 98% of those with asthma. There was a significant correlation between a positive response to MCh in CF and poor pulmonary function. There was no relationship between allergic rhinitis or positive allergen skin tests and a positive MCh response. Dose-response curves and time course to MCh challenge differed in CF and asthma. Bronchial hyperreactivity is thus common in CF but is different from that in asthma.
mesh_terms: D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000276:immunology / Q000503:physiopathology*; D001980:Bronchi / Q000187:drug effects* / Q000276:immunology / Q000503:physiopathology; D002648:Child; D003550:Cystic Fibrosis / Q000235:genetics / Q000276:immunology / Q000503:physiopathology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005541:Forced Expiratory Volume; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D008297:Male; D008688:Methacholine Compounds / Q000494:pharmacology*
chemical_list: D008688:Methacholine Compounds; D006632:Histamine