title: Release of substance P-like immunoreactivity into the antral lumen of cats.
abstract: SPLI can be detected in antral perfusates of cats. Experiments were performed in anesthetized cats provided with antral pouches. The pouches were perfused with 0.1 M HCl and 0.15 M NaCl. The concentration of SPLI in the perfusates was determined by radioimmunoassay. Basal output varied between 0--60 pg/min. Electrical vagal stimulation (2--10 Hz) caused release responses varying between 100--800 pg. Ach given i.v. or intraantrally also released SPLI into the antral lumen as well as adrenaline given i.v.
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D002415:Cats; D004558:Electric Stimulation; D004837:Epinephrine / Q000494:pharmacology; D010477:Perfusion; D011706:Pyloric Antrum / Q000378:metabolism*; D011863:Radioimmunoassay; D013373:Substance P / Q000378:metabolism*; D014630:Vagus Nerve / Q000502:physiology
chemical_list: D013373:Substance P; D000109:Acetylcholine; D004837:Epinephrine