title: [Intrafocal BCG therapy of metastasizing malignant melanoma].
abstract: Therapeutical possibilities and side effects of intrafocal BCG-vaccination into metastases of malignant melanomas are discussed. Only in one of our three cases, this special method of unspecific immunstimulation induced a remarkable regression of tumor size. The second patient showed a partial remission and in the third there was no effect at all. Besides local irritation with ulceration we observed severe generalized side effects in all patients. A granulomatous hepatitis, which represents the most severe complication of this therapeutical method, occurred in one case. Its successful treatment with tuberculostatic agents favors the assumption of an infectious genesis.
mesh_terms: D000328:Adult; D001500:BCG Vaccine / Q000627:therapeutic use*; D005528:Foot; D006801:Humans; D007167:Immunotherapy; D008297:Male; D008545:Melanoma / Q000628:therapy*; D009362:Neoplasm Metastasis; D012878:Skin Neoplasms / Q000628:therapy*
chemical_list: D001500:BCG Vaccine
vernacular_title: Intrafokale BCG-Therapie des metastasierenden malignen Melanoms.