Hepatic iron clearance from serum in treated hemochromatosis.
Hepatic iron uptake from transferrin has been studied in 7 patients with treated hemochromatosis. When compared with a control group with similar serum iron and transferrin saturation the hemochromatotics had a significantly higher 4-hr iron uptake value. Uptake in the precirrhotic and cirrhotic hemochromatotics was not significantly different, suggesting the existence of a cellular abnormality of hepatic iron metabolism in this disease. The results provide an explanation for the development of siderosis in some patients with idiopathic hemochromatosis and a normal serum iron concentration.
D000328:Adult; D000368:Aged; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D001706:Biopsy; D001815:Bloodletting; D005260:Female; D005293:Ferritins / Q000097:blood; D006432:Hemochromatosis / Q000097:blood / Q000378:metabolism* / Q000628:therapy; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007501:Iron / Q000032:analysis / Q000097:blood / Q000378:metabolism*; D007504:Iron Radioisotopes; D008099:Liver / Q000032:analysis / Q000378:metabolism*; D008103:Liver Cirrhosis / Q000097:blood / Q000150:complications / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D014168:Transferrin / Q000032:analysis
D006454:Hemoglobins; D007504:Iron Radioisotopes; D014168:Transferrin; D005293:Ferritins; D007501:Iron; D001219:Aspartate Aminotransferases; D001663:Bilirubin