title: Clinical and pharmacological investigations of the new saluretic azosemid.
abstract: Ple 1053 (Azosemid) is a diuretic which resembles furosemide chemically and in its mode of action. When administered intravenously, Ple 1053 was approximately 5 times more potent on a weight basis than furosemide, its dose-response relationship was closer and the slope was steeper. After oral administration Ple 1053 and furosemide were approximately equal in potency. However, the effect of Azosemid in healthy subjects was relatively prolonged and abrupt peaks did not occur.
mesh_terms: D000284:Administration, Oral; D000328:Adult; D004232:Diuretics / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004573:Electrolytes / Q000097:blood; D005260:Female; D005665:Furosemide / Q000097:blood / Q000494:pharmacology; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D012964:Sodium / Q000652:urine; D013424:Sulfanilamides / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D013997:Time Factors; D013777:Tetrazoles; D013876:Thiophenes; D000096926:Benzenesulfonamides
chemical_list: D004232:Diuretics; D004573:Electrolytes; D005665:Furosemide; D012964:Sodium; D013424:Sulfanilamides; C018222:azosemide; D013777:Tetrazoles; D013876:Thiophenes; D000096926:Benzenesulfonamides