Safe, rapid administration schedule for cis-platinum-mannitol.
Cis-diamminedichloroplatinum (II) cis-plastinum, 25--75 mg/m2, with 40 gm mannitol and fluid were given over 1--2 hours to 40 patients with no evidence of elevated serum creatinine levels. Cis-plantinum was administered every 28 days at a dose of 50 mg/m2 to 22 patients, and 75mg/m2 to 6 patients. Patients received from one to eight courses of therapy with no change in their serum creatinine level. A safe, simple method of cis-platinum administration has been achieved.
D000328:Adult; D000368:Aged; D002945:Cisplatin / Q000008:administration & dosage* / Q000009:adverse effects; D003404:Creatinine / Q000097:blood; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007683:Kidney Tubular Necrosis, Acute / Q000517:prevention & control; D008297:Male; D008353:Mannitol / Q000008:administration & dosage*; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood
D008353:Mannitol; D003404:Creatinine; D002945:Cisplatin