A cell membrane theory of endothelial repair and vertical cell loss after cataract surgery.
Endothelial cell counts were taken of the superior, central and inferior corneas of controls, immediate post-operative cases and a four year post-operative case. A vertical mean cell density was found to correlate well with central densities, and mean vertical cell loss (42%) compared well with central cell loss (44%). There was no trend for vertical cell disparity (VCD) in control eye, but a definite disparity was seen in all post-operative eyes, including the one four years after surgery. A cell membrane stimulus theory is proposed for endothelial cell reparation after endothelial damage describing cessation of cell migration once the defect is covered.
D002387:Cataract Extraction / Q000009:adverse effects*; D002452:Cell Count / Q000379:methods; D002462:Cell Membrane / Q000502:physiology; D002465:Cell Movement; D003315:Cornea / Q000473:pathology* / Q000502:physiology* / Q000601:surgery; D004727:Endothelium / Q000473:pathology / Q000502:physiology; D005500:Follow-Up Studies; D006801:Humans; D014945:Wound Healing