Stretch receptor control of renin release in perfused rat kidney: effect of high perfusate potassium.
1. These studies were conducted in the isolated perfused rat kidney to determine the effect of high perfusate K on the renin release induced by low perfusion pressure, renal vasoconstriction and isoprenaline, and to determine whether the magnitude of the K-induced inhibition equalled that observed with renal vasodilation and high perfusion pressure. 2. Raising perfusate K concentration from 4.2 to 56 mM suppressed basal renin release, and the 56 mM-K inhibited the renin release induced by low perfusion pressure (50 mmHg) or phenylephrine (0.83 micrometers). 3. Isoprenaline (0.79 micrometers) induced a marked increase in renin release; but high perfusate K, propranolol (0.28 mM), papaverine (0.39 mM), or high perfusion pressure (150 mmHg) inhibited this effect. 4. It is concluded that high perfusate K has a powerful inhibitory effect on the renin release induced by renal hypotension, vasoconstriction, and isoprenaline infusion, and that this effect may be mimicked by high perfusion pressure or renal vasodilation. A mechanism is proposed whereby these signals may inhibit renin release by depolarizing the juxtaglomerular granular cells.
D000818:Animals; D001794:Blood Pressure; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D007668:Kidney / Q000098:blood supply / Q000378:metabolism* / Q000502:physiology; D008297:Male; D008465:Mechanoreceptors / Q000502:physiology; D010208:Papaverine / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology / Q000502:physiology*; D051381:Rats; D012039:Regional Blood Flow / Q000187:drug effects; D012083:Renin / Q000378:metabolism*; D012636:Secretory Rate / Q000187:drug effects; D014661:Vasoconstriction
D010656:Phenylephrine; D010208:Papaverine; D012083:Renin; D007545:Isoproterenol; D011188:Potassium