Stimulation of gastric-glucagon release by prostaglandin E1.
The canine gastric fundus has recently been demonstrated to contain and release a material identical by all criteria to pancreatic glucagon (1, 2). Since exogenous prostaglandins have been reported to stimulate pancreatic glucagon release (3) and endogenous prostaglandins are suspected to play a role in the control of glucagon secretion (4), we were interested in seeing if prostaglandin E1 (PGE1) would affect gastric-glucagon release.
D000818:Animals; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D005934:Glucagon / Q000378:metabolism*; D011458:Prostaglandins E / Q000494:pharmacology*
D011458:Prostaglandins E; D005934:Glucagon