Displacement of bilirubin from albumin by indomethacin.
The primary albumin binding site of indomethacin is remote from the bilirubin binding site. Indomethacin is, at most, a weak displacer of bilirubin at low serum drug concentrations. When administered at dosages less than 1 mg/kg, indomethacin would appear to be safe with respect to serum binding of bilirubin in premature infants.
D001663:Bilirubin / Q000097:blood*; D001667:Binding, Competitive; D004912:Erythrocytes / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007213:Indomethacin / Q000097:blood / Q000494:pharmacology*; D010544:Peroxidases; D011485:Protein Binding / Q000187:drug effects; D012709:Serum Albumin / Q000378:metabolism*; D013444:Sulfisoxazole / Q000494:pharmacology
D012709:Serum Albumin; D013444:Sulfisoxazole; D010544:Peroxidases; D001663:Bilirubin; D007213:Indomethacin