Biochemical aspects of chemical carcinogenesis.
This article briefly outlines three major biochemical problems in relation to the presence of chemical carcinogens in mammalian cells: (a) the enzymatic systems responsible for the chemical carcinogen metabolism; (b) the nature of the reactive metabolites and (c) the cellular target(s). References and examples are only given for the field of the polycyclic aromatic hydrocarbons.
D000818:Animals; D001711:Biotransformation; D002273:Carcinogens / Q000378:metabolism*; D002471:Cell Transformation, Neoplastic / Q000139:chemically induced; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D004851:Epoxide Hydrolases / Q000378:metabolism; D051379:Mice; D008862:Microsomes, Liver / Q000201:enzymology; D009097:Multienzyme Complexes / Q000378:metabolism; D009369:Neoplasms / Q000139:chemically induced*; D011083:Polycyclic Compounds / Q000378:metabolism*; D011817:Rabbits
D002273:Carcinogens; D009097:Multienzyme Complexes; D011083:Polycyclic Compounds; D004247:DNA; D003577:Cytochrome P-450 Enzyme System; D004851:Epoxide Hydrolases