[The influence of sodiumnitroprusside on the oxyhaemoglobin dissociation curve in vitro (author's transl)].
Blood from 16 donors was incubated with 3 microgram sodiumnitroprusside (SNP)/ml blood and the PO2 for halfsaturation of haemoglobin at standard pH and temperature was measured. There was no significant shift of the oxygen dissociation curve. Erythrocyte 2, 3 DPG and met-Hb concentrations did not show significant differences between SNP-treated and control blood. Although the red cells and the haemoglobin are involved in the metabolism of SNP, in clinical doses SNP does not alter the oxygen affinity.
D004163:Diphosphoglyceric Acids / Q000378:metabolism; D004912:Erythrocytes / Q000187:drug effects; D005260:Female; D005292:Ferricyanides / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008706:Methemoglobin / Q000378:metabolism; D009599:Nitroprusside / Q000494:pharmacology*; D010108:Oxyhemoglobins / Q000378:metabolism*
D004163:Diphosphoglyceric Acids; D005292:Ferricyanides; D010108:Oxyhemoglobins; D009599:Nitroprusside; D008706:Methemoglobin
Einfluss von Natriumnitroprussid auf die Sauerstoffaffinität des Hämoglobins.