Pentagastrin induction of acetylcholinesterase activity in cerebral cortex of rats.
A single injection of pentagastrin (500 microgram kg-1) produced an immediate (within 15 min) and pronounced increment (about 50%) in the activity of acetylcholinesterase (AChE) in the cerebral but not in the cerebellar region of the brain. Pretreatment of rats with either actinomycin-D or cycloheximide did not fully abolish the pentagastrin-mediated stimulation of cerebral AChE activity.
D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D002531:Cerebellum / Q000187:drug effects / Q000201:enzymology; D002540:Cerebral Cortex / Q000187:drug effects* / Q000201:enzymology; D003513:Cycloheximide / Q000494:pharmacology; D003609:Dactinomycin / Q000494:pharmacology; D008297:Male; D010418:Pentagastrin / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats; D013268:Stimulation, Chemical
D003609:Dactinomycin; D003513:Cycloheximide; D000110:Acetylcholinesterase; D010418:Pentagastrin