[Effect of central m- and n-cholinergic agents on ovarian compensatory hypertrophy in rats].
Stimulation of the n-cholinergic structures by nicotine or depression of m-cholinergic structures by metamizyl inhibited the compensatory ovarian hypertrophy (COH) induced by hemiovariectomy in rats. Stimulation of m-cholinergic structure by arecoline or depression of n-cholinergic structures by n-cholinolytic IEM-506 eliminated the suppression of COH induced by diethylstilbestrol-propionate. The mediatory role of the central-m-cholinergic systems in the mechanisms of COH and that of n-cholinergic systems in the estrogen-induced suppression of COH is suggested.
D000222:Adaptation, Physiological / Q000187:drug effects; D000818:Animals; D002369:Castration; D004347:Drug Interactions; D005260:Female; D006984:Hypertrophy; D010053:Ovary / Q000187:drug effects*; D010276:Parasympatholytics / Q000494:pharmacology*; D010277:Parasympathomimetics / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D010276:Parasympatholytics; D010277:Parasympathomimetics
Vliianie tsentral'nykh m- i n-kholinergicheskikh sredstv na kompensatornuiu gipertrofiiu iaichnika u krys.