title: [Effect of histamine and pentagastrin on the functional state of the hypothalamo-neurohypophyseal secretory system].
abstract: Histochemistry, cario- and zytometry methods showed that the activators of gastric secretion (histamine and pentagastrine) exerted opposite effects upon functional state of hypothalamo-neurohypophyseal secretory system in the guinea-pigs. Histamine (4 mg/kg) activated the system and induced the development of gastric mucosa defects. Pentagastrine (5, 12, 15, 25, and 60 mcg/kg) decreased the activity of the system. No gastric mucosa or duodenum defects developed after pentagastrine administration.
mesh_terms: D000818:Animals; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology*; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects*; D009489:Neurosecretion / Q000187:drug effects; D010286:Paraventricular Hypothalamic Nucleus / Q000187:drug effects / Q000648:ultrastructure; D010418:Pentagastrin / Q000494:pharmacology*; D013495:Supraoptic Nucleus / Q000187:drug effects / Q000648:ultrastructure
chemical_list: D006632:Histamine; D010418:Pentagastrin
vernacular_title: Vliianie gistamina i pentagastrina na funktsional'noe sostoianie gipotalamo-neĭrogipofizarnoĭ sekretornoĭ sistemy.