title: Clearance of neostigmine from the circulation during the antagonism of neuromuscular block.
abstract: The plasma concentration of neostigmine was measured in five patients during the antagonism of neuromuscular block. The concentration of the drug decreased rapidly between 2 and 5 min after administration, and then more slowly. Detectable concentrations of neostigmine were present in plasma after 60 min. In the five patients the distribution half-life of neostigmine was less than 1 min; the elimination half-life ranged from 15.4 to 30.1 min.
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008875:Middle Aged; D009388:Neostigmine / Q000097:blood* / Q000494:pharmacology; D009469:Neuromuscular Junction / Q000187:drug effects*; D013997:Time Factors; D014403:Tubocurarine / Q000494:pharmacology*
chemical_list: D009388:Neostigmine; D014403:Tubocurarine