The possible mode of action of prostaglandins: XIV. Evidence of an involvement of progesterone in the initiation of prostaglandin F2a-induced premature labor in rats.
Prostaglandin F2a (PGF2a) at a dose of 2 mg/kg (sc) on day 18 of pregnancy induced premature emptying of gravid uteri by day 21 in the rat. Bilateral spaying or luteectomy on day 18 of pregnancy induced a refractoriness to respond to the abortifacient action of PGF2a. Injection of progesterone in the spayed or luteectomized pregnant rats, however, restored the sensitivity of the surgically manipulated animals to PGF2a. Premature parturition resulted in all of the animals so far tested. The importance of progesterone in terms of the abortifacient action of PGF2a is discussed.
D000818:Animals; D003338:Corpus Luteum / Q000601:surgery; D005260:Female; D007751:Labor, Induced; D008297:Male; D010053:Ovary / Q000601:surgery; D011247:Pregnancy; D011374:Progesterone / Q000378:metabolism* / Q000494:pharmacology; D011460:Prostaglandins F / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D011460:Prostaglandins F; D011374:Progesterone