The HLA antigens in women with recurrent abnormal pregnancies of unknown etiology.
Women with recurrent abnormal pregnancies of unknown etiology--as compared with those with recurrent abnormal pregnancies of known etiology and with normal controls--had a significantly increased frequency of antigen HLA--A9 (corr. P less than 0.01). Analysis of the frequencies in matings performed at different levels of HLA incompatibility between parents in 35 couples with recurrent abnormal pregnancies of unknown etiology revealed a high degree of wife husband compatibility of the antigens of the HLA--A locus, but not of the antigens of the HLA--B locus. These results indicate that the HLA chromosomal region may influence the reproductive efficiency and the fate of the fetus.
D000022:Abortion, Spontaneous / Q000235:genetics; D000013:Congenital Abnormalities / Q000235:genetics; D005260:Female; D005313:Fetal Death / Q000235:genetics; D005317:Fetal Growth Retardation / Q000235:genetics; D006680:HLA Antigens / Q000032:analysis; D006650:Histocompatibility Testing; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications / Q000235:genetics*; D012008:Recurrence
D006680:HLA Antigens