title: [Antibiotic therapy of experimental intrauterine staphylococcal infection].
abstract: The experiments on gravid rats showed that generalized staphylococcal infection in the female rats resulted in intrauterine infecting of the fetus and had a negative effect on its antenatal development: increased embryonal death rate, decreased weight gain, etc. In case of staphylococcal septicemia the amniotic waters were a peculiar reservoir of the causative agent where it accumulated in larger amounts than in the fetus tissues. Efficiency of oxacillin in daily doses of 144 and 72 mg was shown in treatment of the rat intrauterine infection. High sensitivity of the infected embryons to higher doses of the drug was found.
mesh_terms: D000818:Animals; D004353:Drug Evaluation, Preclinical; D005260:Female; D005315:Fetal Diseases / Q000188:drug therapy / Q000382:microbiology; D010068:Oxacillin / Q000627:therapeutic use*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy / Q000382:microbiology; D051381:Rats; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D014591:Uterine Diseases / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D010068:Oxacillin
vernacular_title: Antibiotikoterapiia éksperimental'noĭ vnutriutrobnoĭ stafilokokkovoĭ infektsii.