Isolation, purification, and antibiotic activity of o-methoxycinnamaldehyde from cinnamon.
o-Methoxycinnamaldehyde has been isolated and purified from powdered cinnamon. The compound inhibits the growth and toxin production of mycotoxin-producing fungi. The substance completely inhibited the growth of Aspergillus parasiticus and A. flavus at 100 microgram/ml and A. ochraceus and A. versicolor at 200 microgram/ml. It inhibited the production of aflatoxin B1 by over 90% at 6.25 microgram/ml, ochratoxin A at 25 microgram/ml, and sterigmatocystin at 50 microgram/ml. The substance also displayed a strong inhibitory effect on the growth of five dermatophytoses species, e.g., Microsporum canis (minimum inhibitory concentration, 3.12 to 6.25 microgram/ml). However, no antibacterial effect was observed at concentrations as high as 50 microgram/ml.
D000171:Acrolein / Q000031:analogs & derivatives / Q000302:isolation & purification* / Q000494:pharmacology; D000447:Aldehydes / Q000302:isolation & purification*; D000840:Anisoles / Q000302:isolation & purification* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology; D001230:Aspergillus / Q000187:drug effects / Q000378:metabolism; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D002935:Cinnamomum zeylanicum / Q000032:analysis*; D003212:Condiments / Q000032:analysis*; D005658:Fungi / Q000187:drug effects; D009183:Mycotoxins / Q000096:biosynthesis; D013045:Species Specificity
D000447:Aldehydes; D000840:Anisoles; D000900:Anti-Bacterial Agents; D009183:Mycotoxins; C017910:2-methoxycinnamaldehyde; D000171:Acrolein