Cell kinetics and the control of growth in long bones.
The cell kinetics of the cartilage growth plate are outlined and discussed in terms of the probable levels of control on the system. Possible mechanisms of growth control at the cellular level are examined for (i) the rate of cell division in the proliferation zone, (ii) the command to differentiate that limits the size of the proliferation zone and (iii) the ageing process in the cartilage plate. The evidence of cell kinetics does not point unequivocally to any particular mechanism.
D000375:Aging; D000818:Animals; D001846:Bone Development; D002356:Cartilage / Q000254:growth & development*; D002454:Cell Differentiation; D002455:Cell Division; D012739:Gonadal Steroid Hormones; D013006:Growth Hormone; D006801:Humans; D010012:Osteogenesis; D051381:Rats
D012739:Gonadal Steroid Hormones; D013006:Growth Hormone