Qa-2 and Qa-3 antigens on lymphocyte subpopulations. I. Mitogen responsiveness.
The effects of anti-Qa-2 plus C and anti-Qa-3 plus C on mitogen-induced proliferation were studied. Both of these antisera in the presence of C markedly reduced both Con A- and PHA-induced proliferation while having little or no effect on LPS-induced proliferation. LPS, Con A, and PHA cultures and cultures containing media alone, examined at 72 hr, contained high proportions of Qa-2+ and Qa-3+ cells.
D000818:Animals; D000941:Antigens; D002478:Cells, Cultured; D003165:Complement System Proteins; D003208:Concanavalin A / Q000494:pharmacology; D007106:Immune Sera / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice; D008934:Mitogens / Q000494:pharmacology*; D010835:Phytohemagglutinins / Q000494:pharmacology
D000941:Antigens; D007106:Immune Sera; D008070:Lipopolysaccharides; D008934:Mitogens; D010835:Phytohemagglutinins; D003208:Concanavalin A; D003165:Complement System Proteins