title: Ischemia of toes as a presenting symptom in primary thrombosis: a case report.
abstract: Although thrombotic occlusion of small vessels in thrombocytosis is allegedly well recognized, it has been reported only rarely. We treated 4 patients with primary thrombocytosis in whom ischemic toe lesions with normal peripheral pulses were the presenting and only symptoms. The symptoms preceded diagnosis by 5 years, 3 years, 1 year, and 1 month respectively. Treatment of the hematologic disorder resulted in disappearance of the toe lesions. Thrombocytosis should be routinely searched for in patients with ischemic toes and normal peripheral pulses.
mesh_terms: D000368:Aged; D006801:Humans; D007511:Ischemia / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D013922:Thrombocytosis / Q000150:complications*; D013927:Thrombosis / Q000175:diagnosis* / Q000209:etiology; D014034:Toes / Q000098:blood supply*