[Role of the spleen in regulating thrombocytopoiesis].
It was shown in experiments on dogs that splenectomy resulted in thrombocytosis, as well as in a decrease of the adhesive-aggregation capacity of platelets and their average life span. Daily thrombocytopoiesis was increased, and a sharp shift in megakariocytogram toward mature forms was noted. Megakaryocytes count in the bone marrow decreased. It is suggested that a factor controlling megakaryocytes cells precursors differentiation was produced in the spleen.
D000818:Animals; D001792:Blood Platelets / Q000502:physiology; D001854:Bone Marrow Cells; D002452:Cell Count; D002682:Chinchilla; D004285:Dogs; D005260:Female; D006410:Hematopoiesis; D008297:Male; D008533:Megakaryocytes; D013154:Spleen / Q000502:physiology*; D013156:Splenectomy; D013997:Time Factors
Rol' selezenki v reguliatsii trombotsitopoéza.