Nucleus accumbens lesions reduce amphetamine hyperthermia but not hyperactivity.
Electrolytic lesions of the nucleus accumbens were found to produce an increase in spontaneous locomotion; additionally, these lesions attenuated the hyperthermic, but not the hyperkinetic, actions of d-amphetamine. These results suggest that while dopamine release from the mesolimbic system may underlie amphetamine-induced hyperthermia, other structures must also be involved in amphetamine-induced hypermotility.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D003913:Dextroamphetamine / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D009714:Nucleus Accumbens / Q000502:physiology*; D051381:Rats; D012686:Septal Nuclei / Q000502:physiology*; D013997:Time Factors
D003913:Dextroamphetamine