[Toxicity by relay. III. Safety for the human consumer of the use of Carbadox, a feed additive for swine, as estimated by a 7 years relay toxicity on dogs].
To check the possible toxicity risks of the meat from swine fed with a residue producing feed additive: Carbadox, a new methodology was used. It is the "Relay Toxicity". Swine were fed with a high dose of the additive and sacrificed without any withdrawal. In such conditions meat contains a high level of residues. The frozen meat was given daily--after thawing--at 100 g or 200 g/dog to 12 beagle dogs, 6 females and 6 males, sacrificed when 87.5 months old (85 months on experiment). On these animals, no anomaly was found: on weight gain and health; on fertility and reproductive performances; on hematology and biochemical values of blood and urine; and after careful macroscopic or microscopic examinations of the animals at safrice. We were able to obtain a safety factor above 9000 when Carbadox is used at the maximum level approved 50 ppm, and the withdrawal 4 weeks before slaughtering. To conclude, the absence of anomaly allows us to confirm the safety for the human consumer when Carbadox is used as a feed additive for swine.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002218:Carbadox / Q000633:toxicity*; D004285:Dogs; D005260:Female; D005298:Fertility / Q000187:drug effects; D005503:Food Additives / Q000633:toxicity; D008297:Male; D008460:Meat / Q000633:toxicity; D011810:Quinoxalines / Q000633:toxicity*; D013552:Swine
D005503:Food Additives; D011810:Quinoxalines; D002218:Carbadox
La toxicite de relais III. securite d'emploi pour le consommateur human du carbadox, facteur de croissance pour le porc, estimee par toxicite de relais d'une duree de sept ans chez le chien beagle.