[Studies on the influsion speed and acute toxicity of amino acid solutions in rats (author's transl)].
Relationships between the infusion speed and lethal dose of several amino acid solutions of various concentrations were studied in male Sprague Dawley rats. When the amino acid solutions were continuously infused at various speeds, a functional relationship between the dose producing a cardiac arrest (DCA) and infusion speed was established. The DCA/infusion speed was characterized by two ranges with an increasing DCA as increase or decrease of infusion speed and by its intermediate range of a flat minimum with a practically constant DCA regardless of varying the infusion speed. A practically constant LD50 was obtained in the infusion of each amino acid solution within the infusion speed in the intermediate range. The LD50 of each amino acid solution was dependent on the crystalloid osmotic pressure.
D000596:Amino Acids / Q000633:toxicity*; D000818:Animals; D006323:Heart Arrest / Q000139:chemically induced; D007263:Infusions, Parenteral; D007928:Lethal Dose 50; D008297:Male; D051381:Rats; D012996:Solutions
D000596:Amino Acids; D012996:Solutions