Effect of oxytocin on the blood glucose concentration.
Blood-glucose concentration is tested in male volunteers before and on the 1st, 3rd, 7th, 15th, 20th, 30th and 60th min after intravenous administration of oxytocin in doses of 0.1 IU/kg. In the first minutes after the injection there is a hypoglycaemic tendency in the changes of the blood glucose concentration, maintained in 60 per cent of the cases, while in the remaining subjects slight hyperglycaemia after the 7th min is observed. Simultaneously, hyperemia of the skin, moderate decrease in the diastolic blood pressure and tachycardia are observed. The effect of oxytocin is associated with increased influx of blood in the adipose tissue, where the glucose is metabolized with the involvement of the specific oxytocin receptors. The late hypoglycaemia is associated with oxytocin-inhibited insulin decomposition, the hyperglycaemia--with the domination of the sympathoadrenal activation in some of the subjects examined. A conclusion is reached that the effect of oxytocin on carbohydrate metabolism is physiologically unimportant.
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D006207:Half-Life; D006801:Humans; D008297:Male; D010121:Oxytocin / Q000378:metabolism / Q000494:pharmacology*; D013997:Time Factors
D001786:Blood Glucose; D010121:Oxytocin