Influence of misonidazole on the incidence of radiation-induced intestinal tumours in mice.
C57BL mice were given local irradiation to 2 cm2 of the lower abdomen in the dose range 16--24 Gy. There were some early deaths, but mice dying between 50--240 days predominantly developed invasive adenocarcinomas of the intestine. When the radiosensitizer misonidazole was given in a single dose shortly before irradiation the proportion of mice developing tumours was higher, but the difference was not statistically significant. However, there was a significant increase in the incidence of multiple tumours, largely attributable to tumours arising in the rectum.
D000230:Adenocarcinoma / Q000453:epidemiology* / Q000473:pathology; D000818:Animals; D002430:Cecal Neoplasms / Q000453:epidemiology; D007414:Intestinal Neoplasms / Q000209:etiology* / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008920:Misonidazole / Q000494:pharmacology*; D009381:Neoplasms, Radiation-Induced / Q000473:pathology; D009593:Nitroimidazoles / Q000494:pharmacology*; D012004:Rectal Neoplasms / Q000453:epidemiology
D009593:Nitroimidazoles; D008920:Misonidazole