["System of recognition" (or "system of preference") for corticosteroids in the hepatocyte plasmatic membrane].
By using fluorescent probes it was shown that hydrocortisone, cortisone and estron decrease the constant of the probe binding with dimethylaminochalcone in the lipid membranes proportional to the distribution coefficient of steroids in the system lipids-water. It is only hydrocortisone and, to a lesser extent, cortisone which produce such an effect in the plasmatic membranes of the hepasytes. The presence of a "preference system" for corticosteroids is presumed in the membranes.
D000305:Adrenal Cortex Hormones / Q000378:metabolism*; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D002599:Chalcone / Q000031:analogs & derivatives / Q000378:metabolism; D003348:Cortisone / Q000378:metabolism; D004970:Estrone / Q000378:metabolism; D005453:Fluorescence; D006854:Hydrocortisone / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism; D011485:Protein Binding / Q000187:drug effects; D051381:Rats; D011987:Receptors, Steroid / Q000378:metabolism*
D000305:Adrenal Cortex Hormones; D008563:Membrane Lipids; D011987:Receptors, Steroid; D004970:Estrone; D002599:Chalcone; D003348:Cortisone; D006854:Hydrocortisone
O "sisteme uznavaniia" (ili "sisteme predpochteniia") dlia kortikosteroidov v plazmaticheskoĭ membrane gepatotsitov.