Effect of 16,16-dimethyl prostaglandin-E2 given intra-arterially or intra-gastrically, on acid secretion by canine stomachs perfused ex vivo.
Isolated whole canine stomachs, perfused ex vivo with homologous blood, were used for studying the effect of 16,16-dimethyl prostaglandin-E2 (dmPGE2) on gastric secretion. DmPGE2 was administered either into the gastric artery or instilled intragastrically through an esophageal cannula. Histamine, infused intra-arterially, induced acid secretion of all ex vivo stomachs and this was significantly inhibited by intra-arterially or intra-gastrically administered dmPGE2: volume of secretion, output of HCl and concentration of H+ were decreased and gastric peripheral vascular resistance was significantly reduced. The inhibitory action of dmPGE2 continued after its administration was stopped.
D000818:Animals; D004285:Dogs; D005750:Gastric Juice / Q000378:metabolism*; D007261:Infusions, Intra-Arterial; D007441:Intubation, Gastrointestinal; D011459:Prostaglandins E, Synthetic / Q000008:administration & dosage / Q000494:pharmacology*
D011459:Prostaglandins E, Synthetic