Determination of thorium series nuclides in thorotrast patients.
Application of gamma-ray spectrometry with a Ge(Li) detector and then instrumental neutron activation analysis to tissue samples from a Thorotrast patient using the same standard reference sample makes it possible to determine both 232Th concentrations and activity ratios of the descendant nuclides to 232Th in living tissues. This analytical method is nondestructive, being simpler and more reliable than the methods previously used. In the present study, the activity ratio of 228Ra/232Th in living tissue was estimated at 0.37 to 0.44, being somewhat lower than the value reported by Kato. As for the activity ratio of 228Th/228Ra, our value agreed fairly well with Kato's value. A stomach sample from a Thorotrast patient was found to contain the same level of 232Th as liver and spleen samples; trace amount of 232Th was also found in kidney and brain samples.
D001923:Brain Chemistry; D006801:Humans; D007668:Kidney / Q000032:analysis; D008099:Liver / Q000032:analysis*; D009501:Neutron Activation Analysis; D011832:Radiation Injuries / Q000378:metabolism*; D011883:Radium / Q000032:analysis; D013051:Spectrometry, Gamma / Q000379:methods; D013154:Spleen / Q000032:analysis; D013270:Stomach / Q000032:analysis; D013910:Thorium / Q000032:analysis*; D013911:Thorium Dioxide / Q000009:adverse effects*
D013910:Thorium; D013911:Thorium Dioxide; D011883:Radium