title: [Cholesterol biosynthesis in the blood of rabbits with experimental atherosclerosis].
abstract: Blood of normal rabbits and those on atherogenic cholesterol diet was incubated with 2--14C-acetate of sodium. After incubation cholesterol and its precursors -- squalene and lanosterin -- were found and identified in the non-saponified fractions of leukocytes and platelets. The maximum specific activity was revealed in cholesterol, next in turn were lanosterin and squalene of leukocytes both in the normal rabbits and in those with atherosclerosis. In platelets the label was mainly accumulated in lanosterin.
mesh_terms: D000085:Acetates / Q000378:metabolism; D000818:Animals; D001161:Arteriosclerosis / Q000097:blood*; D001792:Blood Platelets / Q000378:metabolism; D002784:Cholesterol / Q000096:biosynthesis* / Q000097:blood; D007810:Lanosterol / Q000378:metabolism; D007962:Leukocytes / Q000378:metabolism; D011817:Rabbits; D013185:Squalene / Q000378:metabolism
chemical_list: D000085:Acetates; D007810:Lanosterol; D013185:Squalene; D002784:Cholesterol
vernacular_title: Osobennosti biosinteza kholesterina v krovi krolikov pri éksperimental'nom ateroskleroze.