Plasma mineralocorticoids, plasma renin, and urinary kallikrein in salt-sensitive and salt-resistant rats.
Plasma aldosterone, deoxycorticosterone (DOC), 18-hydroxy-deoxycorticosterone (18OH-DOC), and corticosterone were measured in Dahl salt-sensitive (S) and salt-resistant (R) rats. Plasma corticosterone and DOC were not different between strains but plasma aldosterone was decreased and plasma 18OH-DOC increased in S compared to R. Plasma renin activity and urinary kallikrein excretion were both lower in S than R. Urinary kallikrein is known to vary directly with mineralocorticoid activity and 18OH-DOC is a weak mineralocorticoid. The lower urinary kallikrein in the presence of elevated 18OH-DOC could mean that urinary kallikrein differences between S and R are under independent genetic control from 18OH-DOC.
D015070:18-Hydroxydesoxycorticosterone / Q000097:blood; D000450:Aldosterone / Q000097:blood; D000818:Animals; D001794:Blood Pressure; D001835:Body Weight; D003345:Corticosterone / Q000097:blood; D003900:Desoxycorticosterone / Q000097:blood; D004351:Drug Resistance; D006973:Hypertension / Q000097:blood / Q000235:genetics; D007610:Kallikreins / Q000652:urine*; D008297:Male; D008901:Mineralocorticoids / Q000097:blood*; D051381:Rats; D012083:Renin / Q000097:blood*; D012964:Sodium / Q000378:metabolism*; D012965:Sodium Chloride / Q000494:pharmacology; D014556:Urine
D015070:18-Hydroxydesoxycorticosterone; D008901:Mineralocorticoids; D003900:Desoxycorticosterone; D012965:Sodium Chloride; D000450:Aldosterone; D012964:Sodium; D007610:Kallikreins; D012083:Renin; D003345:Corticosterone