title: Ventricular septal defect due to myocardial infarction.
abstract: This dramatic and ominous complication usually occurs between the third and 14th day after acute myocardial infarction. The size of the defect varies from a pinhole to 4 cm. The sudden appearance of a loud systolic murmur, with or without a thrill, is often accompanied by rapid hemodynamic deterioration. This event must be differentiated from rupture of a papillary muscle with mitral regurgitation. If intensive medical treatment is ineffective, an attempt at surgical repair is indicated.
mesh_terms: D000208:Acute Disease; D006345:Heart Septal Defects, Ventricular / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications*; D011379:Prognosis