Pituitary oncocytic tumor with Cushing's disease.
Pituitary adenomas composed of oncocytes are rare. We report a young female with an atypical oncocytic tumor of the pituitary. The histology was unusual because the oncocytic cells--in addition to an abundance of abnormal mitochondria--contained a conspicuous smooth endoplasmic reticulum. The tumor grew invasively and the patient developed adrenal hypercorticism.
D000236:Adenoma / Q000150:complications / Q000378:metabolism / Q000648:ultrastructure*; D000328:Adult; D003480:Cushing Syndrome / Q000150:complications*; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D008854:Microscopy, Electron; D008928:Mitochondria / Q000648:ultrastructure; D010911:Pituitary Neoplasms / Q000150:complications / Q000378:metabolism / Q000648:ultrastructure*
D006854:Hydrocortisone