Tissue catecholamine and arterial blood pressure changes in non-anaesthetised rats following administration of a new derivative of furanocarboxylic acid with pressor effect.
The effect of a new derivative of furanocarboxylic acid MePAF-4 on the arterial blood pressure, heart rate and the concentration of catecholamines in the brain, heart and adrenals was assessed in non-anaesthetised rats. MePAF-4 was given orally in a single dose of 60 mg/kg (1/30 of LD50)administered during 9 days (at the same daily dose), of injected intravenously in a dose of 10 mg/kg. After intravenous injection MePAF-4 had a significant pressor effect associated with bradycardia but without changes in the tissue concentration of catecholamines. After a single oral dose a slight, transient (60 min) rise of the arterial blood pressure was observed, while the heart rate showed no statistically significant changes. Repeated oral administration of MePAF-4 raised the brain dopamine level and adrenal adrenaline level with simultaneous increase in the weight of these organs. No detectable effects of the long term MePAF-4 administration on the arterial blood pressure and heart rate were observed.
D000284:Administration, Oral; D000311:Adrenal Glands / Q000378:metabolism; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001921:Brain / Q000378:metabolism; D002395:Catecholamines / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D004837:Epinephrine / Q000378:metabolism; D005663:Furans / Q000008:administration & dosage*; D006339:Heart Rate / Q000187:drug effects; D007275:Injections, Intravenous; D008297:Male; D009206:Myocardium / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D011725:Pyridines / Q000008:administration & dosage; D051381:Rats
D002395:Catecholamines; D005663:Furans; D011725:Pyridines; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine