[Effect of amizil and arecoline on 45Ca uptake by rat brain nerve endings].
The effect of benactyzine (amizyl--the central cholinolytic) and arecoline (cholinomimetic) in vitro on the 45Ca uptake by the nerve endings (synaptosomes) of the rat brain was studied. Benactyzine proved to evoke a biphasic change of the isotope uptake, whereas arecoline induced an initial rapid increase of the 45Ca uptake. Benactyzine suppressed the influence of arecoline and of depolarization on the isotope uptake. A conclusion was drawn that an increase of the 45Ca uptake under the action of arecoline was connected with activization of the Na-K canals. On the contrary, benactyzine depressed the permeability of these canals for 45Ca and activated the calcium canals proper.
D000818:Animals; D001115:Arecoline / Q000494:pharmacology*; D001535:Benactyzine / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure*; D002118:Calcium / Q000378:metabolism*; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects; D051381:Rats; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism
D007473:Ion Channels; D001115:Arecoline; D001535:Benactyzine; D002118:Calcium
Vliianie amizila i arekolina na zakhvat 45Ca nervnymi okonchaniiami golovnogo mozga krys.