title: The relationship between total dose, number of fractions and fractions size in the response of malignant melanoma in patients.
abstract: The response of melanomas was assessed retrospectively from the clinical notes on 52 patients from three centres in the United Kingdom. The response was very variable. A tentative isoeffect curve was fitted to the UK data which gave a good fit to data from a prospective study from Yale. Clinical data from the Melbourne Clinic on response and fraction size showed a similar response to that from the UK and the combined data showed that the response to fraction sizes of 400-800 rad was significantly better (p about 0.01) than to fraction sizes of 200-299 rad.
mesh_terms: D000328:Adult; D000368:Aged; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000532:radiotherapy*; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011879:Radiotherapy Dosage; D012189:Retrospective Studies