Lifespan carcinogenicity studies with hexachlorophene in mice and rats.
Hexachlorophene (HCP) was tested for carcinogenicity in lifetime feeding studies in male Sprague--Dawley rats that were fed on a protein- and vitamin-deficient diet and in C57B1 and XVII/G mice that received the chemical incorporated into a complete diet. After 2 years, no significant carcinogenic effects were observed in these animals. In XVII/G mice injected subcutaneously at birth or receiving HCP via the mother's milk, the incidence of tumors was not statistically increased. No carcinogenic effect was observed in (C57B1 X C3H) F1 hybrid mice that received HCP transplacentally.
D000284:Administration, Oral; D000367:Age Factors; D000818:Animals; D002273:Carcinogens; D005260:Female; D006582:Hexachlorophene / Q000008:administration & dosage / Q000633:toxicity*; D007774:Lactation; D008297:Male; D008431:Maternal-Fetal Exchange; D051379:Mice; D008815:Mice, Inbred Strains; D011247:Pregnancy; D051381:Rats; D013997:Time Factors
D002273:Carcinogens; D006582:Hexachlorophene