title: Changes in plasma noradrenaline concentration as a measure of release rate.
abstract: 1 A method is described for repeated sampling of plasma noradrenaline (NA) in freely moving rats. Na concentration does not change during the day or after adrenalectomy. 2 Exogenous NA has a half-life of 1.5 min; drugs which block neuronal and extra-neuronal uptake lengthen this to 6.3 min. 3 Swim-stress leads to a steep rise followed by a rapid decline in plasma NA concentration. 4 This method of plasma NA sampling can serve as a measure of both steady and rapid changes in release rate over long periods of time.
mesh_terms: D000315:Adrenalectomy; D000818:Animals; D006207:Half-Life; D007700:Kinetics; D008297:Male; D009638:Norepinephrine / Q000097:blood / Q000378:metabolism*; D051381:Rats; D013312:Stress, Physiological / Q000378:metabolism; D013550:Swimming; D013997:Time Factors
chemical_list: D009638:Norepinephrine