Alpha and beta adrenergic stimulants in bronchiolitis and wheezy bronchitis in children under 18 months of age.
Total respiratory resistance was measured before and after nebulised phenylephrine in 5 babies (age range 7 to 17 months) with wheezy bronchitis, and in 2 babies (aged 2 and 6 months) with bronchiolitis. None showed a change in resistance after treatment. Total respiratory resistance was measured before and after nebulised adrenaline in another 14 babies (age range 4 to 13 months) with bronchiolitis. No fall in resistance was noted in any baby after treatment whether or not it was given by a conventional or an ultrasonic nebuliser. We conclude that alpha- and beta-adrenergic stimulants are ineffective in bronchiolitis and wheezy bronchitis in children under 18 months of age.
D000336:Aerosols; D000403:Airway Resistance; D001991:Bronchitis / Q000188:drug therapy* / Q000503:physiopathology; D004837:Epinephrine / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010656:Phenylephrine / Q000008:administration & dosage / Q000627:therapeutic use*
D000336:Aerosols; D010656:Phenylephrine; D004837:Epinephrine