Microbial production of essential amino acid with Corynebacterium glutamicum mutants.
Amino acids produced by microbial process are generally L-forms. The stereospecificity of the amino acids produced by fermentation makes the process advantageous compared with synthetic process. Microorganisms employed in microbial process for amino acid production are divided into 4 classes; wild-type strain, auxotrophic mutant, regulatory mutant and auxotrophic regulatory mutant. Using such mutants of Corynebacterium glutamicum, all the essential amino acids but L-methionine are now being produced by "direct fermentation" from cheap carbon sources such as carbohydrate materials or acetic acid.
D000601:Amino Acids, Essential / Q000096:biosynthesis*; D003352:Corynebacterium / Q000378:metabolism*; D005285:Fermentation; D007700:Kinetics; D007930:Leucine / Q000096:biosynthesis; D008239:Lysine / Q000096:biosynthesis; D009154:Mutation; D010649:Phenylalanine / Q000096:biosynthesis; D013045:Species Specificity; D013237:Stereoisomerism; D013912:Threonine / Q000096:biosynthesis; D014364:Tryptophan / Q000096:biosynthesis
D000601:Amino Acids, Essential; D013912:Threonine; D010649:Phenylalanine; D014364:Tryptophan; D007930:Leucine; D008239:Lysine