title: The cell-to-cell channel.
abstract: Cells of most organized tissues are interconnected at their junctions by aqueous membrane channels, shown in one instance to be at least 14--16 A in diameter. During junction formation, nascent channels are detected as quantal steps in cell-to-cell conductance, growing progressively in number. The channels detected are stable. Elevation of cytoplasmic free Ca2+ concentration can cause graded closure of channels.
mesh_terms: D000818:Animals; D002118:Calcium / Q000494:pharmacology; D002450:Cell Communication; D002463:Cell Membrane Permeability / Q000187:drug effects; D004553:Electric Conductivity; D007365:Intercellular Junctions / Q000502:physiology* / Q000648:ultrastructure; D007473:Ion Channels / Q000502:physiology / Q000648:ultrastructure; D007700:Kinetics; D008970:Molecular Weight; D014981:Xenopus
chemical_list: D007473:Ion Channels; D002118:Calcium