Bone mineral turnover in a patient with osteogenesis imperfecta estimated by fluoride excretion.
A child with severe osteogenesis imperfecta was treated with NaF for 8 years, at the end of which time his iliac bone contained 29 mg F/g Ca. Urine F was assayed at intervals for 4.5 years after discontinuing treatment. After the first few days the decline in urinary F excretion can be described by a two component exponential function, with half-times of 5.4 months (10%) and 8.9 years (90%). The latter half-time value is of the same order of magnitude as those observed for F and other "bone-seeking" elements in normal subjects, which suggests that the turnover rate of bone mineral is normal in this disease. Three methods for estimating the attained body F burden at the end of NaF treatment--namely, metabolic balance, bone biopsy, and integration of the exponential function--yielded comparable values.
D001842:Bone and Bones / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D005459:Fluorides / Q000378:metabolism*; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010013:Osteogenesis Imperfecta / Q000188:drug therapy / Q000378:metabolism*; D012969:Sodium Fluoride / Q000378:metabolism* / Q000627:therapeutic use
D012969:Sodium Fluoride; D005459:Fluorides