title: Upper-limb-cardiovascular syndrome. Two cases of Holt-Oram syndrome.
abstract: Two cases of Holt-Oram syndrome with an atrial septal defect and thumb deformities are reported. The embryological basis for the association between skeletal malformations particularly of the hand, and congenital heart disease, is discussed.
mesh_terms: D000015:Abnormalities, Multiple / Q000196:embryology; D002648:Child; D002675:Child, Preschool; D006225:Hand / Q000196:embryology; D006228:Hand Deformities, Congenital; D006330:Heart Defects, Congenital / Q000150:complications* / Q000196:embryology; D006801:Humans; D007223:Infant; D008297:Male; D013577:Syndrome; D013933:Thumb / Q000002:abnormalities / Q000196:embryology