A macrophage tumor cell line and plasminogen activator. A potential model system for macrophage regulation of enzyme production.
The macrophage cell line, RAW264.10, synthesizes and secretes plasminogen activator. Production of this enzyme is inhibited by low concentrations of glucocorticoids and increased by phorbol myristate acetate. It is proposed that this line could be a suitable model for the regulation of enzyme synthesis by mouse peritoneal macrophages.
D002460:Cell Line; D005938:Glucocorticoids / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism*; D010960:Plasminogen Activators / Q000378:metabolism*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D005938:Glucocorticoids; D010960:Plasminogen Activators; D013755:Tetradecanoylphorbol Acetate