title: [Basic results of an experiment with mammals on the Kosmos-782 biosatellite].
abstract: The rat experiments carried out onboard the biosatellite Cosmos-782 contributed to our understanding of mechanisms of animal adaption to prolonged weightlessness. Postflight analysis helped to study nonspecific changes related to the stress-reaction accompanying space flight and return to the Earth gravity as well as specific changes associated with functional unloading of the musculoskeletal system in weightlessness. The flight results confirmed the previously made conclusions concerning possible adaptation of mammals to prolonged weightlessness and lack of pathological changes in vital weightlessness. They included: metabolic and hormonal changes, muscle atrophy, osteoporosis and delayed bone growth, decrease of ATPase activity of myocardial myosin, inhibition of erythropoiesis.
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D000830:Animals, Laboratory / Q000502:physiology*; D001835:Body Weight; D001842:Bone and Bones / Q000502:physiology; D008297:Male; D009132:Muscles / Q000502:physiology; D009929:Organ Size; D051381:Rats; D012149:Restraint, Physical / Q000295:instrumentation; D013026:Space Flight; D013312:Stress, Physiological / Q000503:physiopathology; D013997:Time Factors; D014586:USSR; D014893:Weightlessness / Q000009:adverse effects
vernacular_title: Osnovnye rezul'taty éksperimenta s mlekopitaiushchimi na biosputnike "Kosmos-782".