title: [Phenotypic changes in acetylation in tumor patients].
abstract: The authors have determined the activity of N-acetyltransferase and the type of acetylation in patients with cancer of the lung (38) and gastrointestinal tract (39), and in 72 control individuals. It was found that there is a changed distribution of patients in relation to the activity of acetylation in maintaining the normal correlation of "slow" and "fast" acetylators. There was noted an increase in N-acetyltransferase activity with greater spread of the tumor process, whereas the activity decreased in radical operations and increased in palliative surgical procedures and in the presence of recurrences or metastases.
mesh_terms: D000107:Acetylation; D000123:Acetyltransferases / Q000235:genetics*; D000328:Adult; D000368:Aged; D004789:Enzyme Activation; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000201:enzymology / Q000235:genetics; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000235:genetics*; D010641:Phenotype; D013418:Sulfamethazine / Q000097:blood; D013997:Time Factors
chemical_list: D013418:Sulfamethazine; D000123:Acetyltransferases
vernacular_title: Fenotipicheskie izmeneniia v atsetilirovanii u opukholevykh bol'nykh.