Antiviral activity of some beta-diketones. 4. Benzyl diketones. In vitro activity against both RNA and DNA viruses.
The synthesis and in vitro antiviral evaluation of a series of substituted benzyl beta-diketones are described. The introduction of a styryl group onto the phenyl ring enhanced activity against herpesvirus type 2. The 4-methoxystyryl homologue 8 was evaluated extensively in vitro and was found to be effective against both RNA and DNA viruses. Compound 8 was evaluated in the mouse vagina against herpes simplex type 1 and produced a significant increase in survival rate as well as in survival time.
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D001593:Benzyl Compounds / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use; D046508:Culture Techniques; D004267:DNA Viruses / Q000187:drug effects*; D005260:Female; D006561:Herpes Simplex / Q000188:drug therapy; D007659:Ketones / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D051379:Mice; D009924:Organ Culture Techniques; D012328:RNA Viruses / Q000187:drug effects*
D000998:Antiviral Agents; D001593:Benzyl Compounds; D007659:Ketones