title: [Experimental differentiation in animals of oral and inhaled lead burden from combined absorption of industrial emissions].
abstract: Trials in sheep and rabbits were performed in an area of industrial immissions in the summer months of 1974--1976, to differentiate oral and inhalative lead actions. The animals lived at different distances and in different directions from a lead emitting factory. Hematological and biochemical assays showed that only the measure of the activity of aminolevulinic acid dehydratase produces most significant results of the inhalative influences of lead. To state effects after oral ingestions the estimation of ALA-D and of free erythrocyte porphyrines were suitable. The inhalation of air with lead content between 2 and 14 micrograms/m3 reduced the activity of ALA-D, if the lead content of feed did not exceed the value of 35 ppm. After feeding a lead concentration of more than 35 ppm, the influence of the inhalative action was superposed by the action of the oral intake. The inhalative action can only be demonstrated after a low oral intake. The results indicate that inhalative actions of lead can be proven in an open field area around a lead emitting factory.
mesh_terms: D000042:Absorption; D000284:Administration, Oral; D000336:Aerosols; D000388:Air / Q000032:analysis; D000818:Animals; D001822:Body Burden; D005260:Female; D005504:Food Analysis; D007220:Industrial Waste / Q000032:analysis; D007854:Lead / Q000008:administration & dosage / Q000032:analysis / Q000378:metabolism*; D008297:Male; D000623:Porphobilinogen Synthase / Q000378:metabolism; D011817:Rabbits
chemical_list: D000336:Aerosols; D007220:Industrial Waste; D007854:Lead; D000623:Porphobilinogen Synthase
vernacular_title: Tierexperimentelle differenzierung von oralen und inhalativen Bleibelastungen bei kombinierter aufnahme in einem Immissionsgebiet.