[AMP-deaminase activity of rat brain nuclear and mitochondrial fractions].
It is established that purified nuclear and mitochondrial fractions of the rat brain possess a noticeable AMP-deaminase activity. ATP is an effective activator of AMP-deaminase in the both fractions, but this enzyme is also stimulated by hexokinase in the mitochondrial fraction. The ammonia production from ADP in the mitochondrial fraction is connected with the formation on ATP and AMP under the influence of myokinase and subsequent deamination of AMP by AMP-deaminase.
D000659:AMP Deaminase / Q000378:metabolism*; D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000201:enzymology*; D002467:Cell Nucleus / Q000201:enzymology*; D004789:Enzyme Activation; D006593:Hexokinase / Q000378:metabolism; D008928:Mitochondria / Q000201:enzymology* / Q000648:ultrastructure; D009709:Nucleotide Deaminases / Q000378:metabolism*; D051381:Rats
D000255:Adenosine Triphosphate; D006593:Hexokinase; D009709:Nucleotide Deaminases; D000659:AMP Deaminase
AMP-dezaminaznaia aktivnost' iadernoĭ i mitokhondrial'noĭ fraktsiĭ tkani mozga.