title: Pharmacokinetics of cefamandole in infants and children.
abstract: In infants less than 3 months of age, the serum concentration of cefamandole during therapy was higher and more prolonged than that in children older than 1 year. A dosage of 37 mg/kg administered intravenously at 6-h intervals provided a serum concentration in excess of the minimum inhibitory concentrations of common bacterial pathogens for 4 h, and in young infants for 5 h, after dosing.
mesh_terms: D000293:Adolescent; D002435:Cefamandole / Q000378:metabolism*; D002511:Cephalosporins / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D006207:Half-Life; D006801:Humans; D007223:Infant; D007231:Infant, Newborn
chemical_list: D002511:Cephalosporins; D002435:Cefamandole