Effects of synthetic and natural lysophosphatidic acids on the arterial blood pressure of different animal species.
Intravenous injection of lysophosphatidic acid was found to cause hypertension in rats and guinea pigs, but hypotension in cats and rabbits. The potencies of the pressor and depressor effects of synthetic lysophosphatidic acids in rats and cats depended on their chain length and the degree of unsaturation of their fatty acyl moieties.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002415:Cats; D004305:Dose-Response Relationship, Drug; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology; D006168:Guinea Pigs; D008244:Lysophosphatidylcholines; D010712:Phosphatidic Acids / Q000008:administration & dosage / Q000138:chemical synthesis / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D013045:Species Specificity
D005231:Fatty Acids, Unsaturated; D008244:Lysophosphatidylcholines; D010712:Phosphatidic Acids