Growth hormone enhances basement membrane thickening in experimental diabetes. A preliminary report.
Injection of porcine growth hormone (200 microgram) or saline 5 days a week for 16 to 20 weeks in streptozotocin-diabetic rats showed that compared to saline growth hormone produced a 2 1/2-fold larger increase in glomerular capillary basement membrane thickness (2p = 0.027). The possible significance of this effect of an elevated level of growth hormone for diabetic microangiopathy is discussed.
D000818:Animals; D001485:Basement Membrane / Q000166:cytology / Q000187:drug effects*; D002196:Capillaries; D003921:Diabetes Mellitus, Experimental / Q000473:pathology*; D003928:Diabetic Nephropathies / Q000139:chemically induced; D005260:Female; D013006:Growth Hormone / Q000009:adverse effects* / Q000494:pharmacology; D007678:Kidney Glomerulus / Q000098:blood supply; D051381:Rats
D013006:Growth Hormone