[Synthetic medium for the biosynthesis of tobramycin].
The effect of the sources of carbon and inorganic nitrogen on the biosynthesis of tobrmycin complex was studied. Maltose and ammonium chloride were shown tobe optimal. A synthetic medium for Streptomyces cremeus var. nov. 2242, to tobramyc in producing organism, was elaborated and its optimization was performed using the experiment mathematical modelling, i. e. the method of latin squares. Tobramycin production on the new medium was 6 to 7 times higher than that on the initial medium.
D000643:Ammonium Chloride / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D002119:Calcium Carbonate / Q000378:metabolism; D002244:Carbon / Q000378:metabolism; D003470:Culture Media / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D009584:Nitrogen / Q000378:metabolism; D013302:Streptomyces / Q000378:metabolism; D014031:Tobramycin / Q000096:biosynthesis*
D000900:Anti-Bacterial Agents; D003470:Culture Media; D000643:Ammonium Chloride; D002244:Carbon; D002119:Calcium Carbonate; D009584:Nitrogen; D014031:Tobramycin
Sinteticheskaia sreda dlia biosinteza tobramitsina.