title: [Mineralocorticoid function of the adrenal cortex and the renin--angiotensin system in Itsenko-Cushing's disease].
abstract: Mineralocorticoid function of the adrenal cortex and the activity of the renin-angiotensin system were studied in patients with Itsenko-Cushing's disease before (36 cases) and after (27 cases) the treatment with chloditan--an adrenocortical inhibitor. Minertalocorticoid function of the adrenal cortex was assessed by the blood immunoreactive aldosterone content, urinary 18-aldosterone-glucuronide excretion, and the rate of aldosterone secretion. Condition of the renin-angiotensin system was assesed by the blood renin activity. Aldosterone and renin concentration was studied by the radioimmunological method. There proved to be a reverse relationship between the blood aldosterone concentraiton and the severity of Itsenko-Cushing's disease. Elevation of the mineralocorticoid function of the adrenal cortex in Itsenko-Cushing's disease was due to activation of the renin angiotensin system. During clinical remission of the disease following a course of chloditan treatment the patient displayed an increased blood aldosterone level and a rise of its secretion. The minralocorticoid function of the adrenal cortex was intensified at the state of clinical remission because of an increased blood corticotropin concentration.
mesh_terms: D000293:Adolescent; D000302:Adrenal Cortex / Q000503:physiopathology*; D000328:Adult; D000450:Aldosterone / Q000031:analogs & derivatives / Q000097:blood / Q000378:metabolism; D000809:Angiotensins / Q000097:blood*; D003480:Cushing Syndrome / Q000188:drug therapy / Q000503:physiopathology*; D005965:Glucuronates / Q000652:urine; D006801:Humans; D008875:Middle Aged; D008901:Mineralocorticoids / Q000502:physiology*; D008939:Mitotane / Q000627:therapeutic use; D012075:Remission, Spontaneous; D012083:Renin / Q000097:blood*
chemical_list: D000809:Angiotensins; D005965:Glucuronates; D008901:Mineralocorticoids; D000450:Aldosterone; D008939:Mitotane; D012083:Renin
vernacular_title: Mineralokortikoidnaia funktsiia kory nadpochechnikov i renin--angiotenzinnaia sistema pri bolezni Itsenko-Kushinga.