Study of influence of sex and age on human serum lysosomal enzymes by using 4-methylumbelliferyl substrates.
The sex and age dependence of activity of eight glycosidases and acid phosphatase was assayed in serum samples using the 4-methylumbelliferyl substrates. The activity of these enzymes does not change in relation to sex and to age except for acid phosphatase and beta-galactosidase which show significantly higher values in children as compared to adults. The usefulness of the 4-MU substrates for the detection of homozygotes for those lysosomal diseases involving one of the glycosidases studied is discussed.
D000135:Acid Phosphatase / Q000097:blood*; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001192:Arylsulfatases / Q000097:blood; D002648:Child; D002675:Child, Preschool; D005260:Female; D006026:Glycoside Hydrolases / Q000097:blood*; D006720:Homozygote; D006801:Humans; D006923:Hymecromone / Q000031:analogs & derivatives; D007223:Infant; D008247:Lysosomes / Q000201:enzymology*; D008297:Male; D012737:Sex Factors
D006923:Hymecromone; D000135:Acid Phosphatase; D001192:Arylsulfatases; D006026:Glycoside Hydrolases