Chlorpropamide-alcohol flushing: a dominantly inherited trait associated with diabetes.
A simple test was devised to identify people susceptible to chlorpropamide-alcohol flushing (CPAF). Subjects were given a placebo tablet, followed by sherry 12 and 36 hours later. They then received a chlorpropamide tablet and sherry again after 12 and 36 hours. This single-dose challenge test was given to non-insulin-dependent diabetics, insulin-dependent diabetics, and normal subjects. CPAF was common in the non-insulin-dependent diabetics but rare in the other groups. When the test was used in identical twins and families of affected subjects CPAF appeared to be a dominantly inherited trait. We conclude that facial flushing after alcohol in people taking chlorpropamide is related to non-insulin-dependent diabetes, especially when there is a strong family history of diabetes, but not to insulin-dependent diabetes. It is a dominantly inherited trait.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000434:Alcoholic Beverages / Q000009:adverse effects*; D001821:Blushing; D002648:Child; D002747:Chlorpropamide / Q000009:adverse effects*; D048909:Diabetes Complications; D004342:Drug Hypersensitivity / Q000150:complications / Q000235:genetics*; D005799:Genes, Dominant; D006801:Humans; D008875:Middle Aged; D014666:Vasomotor System / Q000187:drug effects*
D002747:Chlorpropamide