title: Suppression by essential fatty acids of experimental allergic encephalomyelitis is abolished by indomethacin.
abstract: Experimental allergic encephalomyelitis in Lewis rats was suppressed by treatment with essential fatty acids (EFA) given perorally. This treatment effect could be abolished by administration of a drug (Indomethacin) known to inhibit biosynthesis of certain prostaglandins from EFA. This observation suggests that the suppressive effect of EFA on cell-mediated immune reactions is brought about by EFA-derived prostaglandins.
mesh_terms: D000818:Animals; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000188:drug therapy* / Q000473:pathology; D005228:Fatty Acids, Essential / Q000037:antagonists & inhibitors* / Q000627:therapeutic use; D005260:Female; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D051381:Rats
chemical_list: D005228:Fatty Acids, Essential; D007213:Indomethacin