Effect of administration of isatin on alkaline phosphatase of various organs of rat.
In vivo administration of isatin (200 mg/kg) significantly lowered the activity of rat kidney alkaline phosphatase after 5 hr but enhanced the activity of rat duodenal and jejunal enzyme after 2 and 5 hr (P less than 0.01). The increased activity of the duodenal and jejunal alkaline phosphatase might be due to the induction of the enzyme by isatin.
D000469:Alkaline Phosphatase / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects; D003513:Cycloheximide / Q000494:pharmacology; D006321:Heart / Q000187:drug effects; D007211:Indoles / Q000494:pharmacology*; D007421:Intestine, Small / Q000187:drug effects; D007510:Isatin / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008297:Male; D051381:Rats
D007211:Indoles; D007510:Isatin; D003513:Cycloheximide; D000469:Alkaline Phosphatase