Trans-delta-9-tetrahydrocannabinol: effects on macromolecular content of mouse liver tissue.
Mice were starved for 72 hours then injected with a total of 50 mg/kg THC over 48 hours during which time the animals were fed ad libitum. At the end of the 48 hours, the mice were sacrificed and the livers were analyzed quantitatively for DNA, RNA, protein, and glycogen. It was determined that the THC had no effect on the DNA or glycogen levels. The amount of RNA increased significantly when compared to controls while protein levels decreased by 50%.
D000818:Animals; D004247:DNA / Q000378:metabolism; D013759:Dronabinol / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D051379:Mice; D011506:Proteins / Q000378:metabolism; D012313:RNA / Q000378:metabolism
D008112:Liver Glycogen; D011506:Proteins; D012313:RNA; D013759:Dronabinol; D004247:DNA