A new warfarin metabolite: structure and function.
The metabolism of the clinically utilized, anticoagulant warfarin [4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one] by rat liver microsomes has been investigated. The structure of a new warfarin metabolite [4-hydroxy-3-(3-oxo-1-phenyl-1-butenyl)-2H-1-benzopyran-2-one] (dehydrowarfarin) has been determined by mass spectral comparison with the chemically synthesized compound. The formation of dehydrowarfarin is catalyzed by cytochrome P-450 and is unusual in that the final product is effectively dehydrogenated warfarin.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004790:Enzyme Induction / Q000187:drug effects; D066298:In Vitro Techniques; D008862:Microsomes, Liver / Q000378:metabolism; D009153:Mutagens; D051381:Rats; D012475:Salmonella / Q000187:drug effects / Q000235:genetics; D013237:Stereoisomerism; D010837:Vitamin K 1 / Q000037:antagonists & inhibitors; D014859:Warfarin / Q000138:chemical synthesis / Q000378:metabolism* / Q000494:pharmacology
D009153:Mutagens; D014859:Warfarin; D010837:Vitamin K 1; D003577:Cytochrome P-450 Enzyme System