[Ability of cells in tissue culture to recover from damage caused by chemotherapeutic drugs].
The repair of potential lethal damages was investigated in the LL cell line induced by some chemicals. Three different chemical compounds were used. An inhibitor of DNA synthesis--hydroxyurea, an alkylating agent--methylnitrosourea, and an antibiotic intercalating in DNA--actinomycin D. It was shown that damages induced by hydroxyurea could be repaired. Unlike, the repair of damages induced by methylnitrosourea and actinomycin D was not observed.
D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003609:Dactinomycin / Q000506:poisoning*; D004305:Dose-Response Relationship, Drug; D006918:Hydroxyurea / Q000506:poisoning*; D008770:Methylnitrosourea / Q000506:poisoning*; D009607:Nitrosourea Compounds / Q000506:poisoning*
D009607:Nitrosourea Compounds; D003609:Dactinomycin; D008770:Methylnitrosourea; D006918:Hydroxyurea
Sposobnost' kletok v kul'ture tkani vosstanavlivat'sia ot povrezhdeniĭ, indutsirovannykh nekotorymi khimioterapevticheskimi preparatami.