Inhibitory effect of tiaramide on ADP-induced aggregation in rabbit platelets.
Tiaramide in 10(-4) or 10(-5) M depressed the ADP-induced aggregation of rabbit platelets using the turbidimetric method. In modified Chandler's loop method, tiaramide in the same concentration accelerated the restoration of the time course of disaggregation.
D000244:Adenosine Diphosphate / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D052160:Benzothiazoles; D007213:Indomethacin / Q000494:pharmacology; D010879:Piperazines / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D011817:Rabbits; D013844:Thiazoles / Q000494:pharmacology*
D052160:Benzothiazoles; D010879:Piperazines; D013844:Thiazoles; D000244:Adenosine Diphosphate; C003468:tiaramide; D001241:Aspirin; D007213:Indomethacin