Studies of autoimmune induction in the rat lacrimal gland.
Induction of autoimmunity in the rat lacrimal gland was presently assessed. Antibodies to lacrimal gland extract were detectable in 58% of the immunized rats. Skin tests were positive at 4 week postimmunization in 70% of the animals. Histological observations revealed the presence of mononuclear cell infiltrates surrounding the ductal and acinar epithelium at 2--6 weeks.
D000818:Animals; D000917:Antibody Formation; D001323:Autoantibodies; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006968:Hypersensitivity, Delayed; D007765:Lacrimal Apparatus / Q000276:immunology* / Q000473:pathology; D008297:Male; D051381:Rats
D001323:Autoantibodies