Aluminium phosphate but not calcium phosphate stimulates the specific IgE response in guinea pigs to tetanus toxoid.
The ability of aluminium phosphate and calcium phosphate to stimulate the synthesis of tetanus toxoid-specific anaphilactic and antitoxic antibodies is compared. The observed differences in the kinetics of IgG1a, IgG1b and antitoxines are quantitative--titres after application of aluminium phosphate are higher. Booster immunization with aluminium but not calcium phosphate-adsorbed toxoid leads to a prolonged synthesis of specific IgE. It is hypothesized that the regular application of aluminium compound-containing vaccines on the entire population could be one of the factors leading to the observed increase of allergic diseases.
D000535:Aluminum / Q000494:pharmacology*; D000707:Anaphylaxis / Q000276:immunology; D000818:Animals; D000917:Antibody Formation; D000918:Antibody Specificity; D002130:Calcium Phosphates / Q000494:pharmacology*; D006168:Guinea Pigs; D007073:Immunoglobulin E / Q000096:biosynthesis*; D007074:Immunoglobulin G / Q000096:biosynthesis; D007700:Kinetics; D008297:Male; D010710:Phosphates / Q000494:pharmacology*; D013745:Tetanus Toxoid / Q000276:immunology*
D002130:Calcium Phosphates; D007074:Immunoglobulin G; D010710:Phosphates; D013745:Tetanus Toxoid; D007073:Immunoglobulin E; D000535:Aluminum