Identification of six substituted 4''-hydroxy-metabolites of of delta1-tetrahydrocannabinol in mouse liver.
4''-Hydroxylation is shown to be a major metabolic route for delta1-tetrahydrocannabinol (delta1-THC) in the mouse. Metabolites were extracted from the livers of mice treated with delta1-THC and examined by combined gas chromatography-mass spectrometry. The 7-hydroxy-6alpha,7-dihydroxy-, 6-oxo- and 7-hydroxy-6-oxo- derivatives of 4''-hydroxy-delta1-THC together with the 4''-hydroxy- and 4'',6alpha-dihydroxy-derivatives of delta1-THC-7-oic acid were identified. Only the diol, 4'',7-dihydroxy-delta1-THC has been reported previously.
D000818:Animals; D002849:Chromatography, Gas; D013759:Dronabinol / Q000378:metabolism*; D006900:Hydroxylation; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism*; D008297:Male; D013058:Mass Spectrometry; D051379:Mice
D013759:Dronabinol