Comparison of prostaglandin and hypertonic saline for termination of pregnancy.
The abortifacient efficacy and complication rate of the administration of hypertonic saline intraamniotically to 796 women were compared with those following administration of various prostaglandins by several routes to 3783 women. Intraamniotic administration of 2.5 mg 15-methyl-PGF2alpha or repeated vaginal administration of 15-methyl PGF2alpha methyl ester were both highly effective. The interval from treatment to abortion following prostaglandin administration was significantly shorter than that following hypertonic saline. The frequency of complications varied with prostaglandin compound and route of administration but was generally of the same magnitude as that following hypertonic saline administration. None of the prostaglandin-treated patients experienced epileptic seizures, and no maternal deaths occurred.
D000028:Abortion, Induced; D001803:Blood Transfusion; D002584:Cervix Uteri / Q000293:injuries; D003967:Diarrhea / Q000139:chemically induced; D005260:Female; D005402:Fistula / Q000209:etiology; D006801:Humans; D011183:Postoperative Complications; D011247:Pregnancy; D011460:Prostaglandins F / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D011461:Prostaglandins F, Synthetic / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D012965:Sodium Chloride / Q000627:therapeutic use*; D013997:Time Factors; D002577:Uterine Cervical Diseases / Q000209:etiology; D014620:Vacuum Extraction, Obstetrical; D014839:Vomiting / Q000139:chemically induced
D011460:Prostaglandins F; D011461:Prostaglandins F, Synthetic; D012462:Saline Solution, Hypertonic; D012965:Sodium Chloride