title: Reduced myocardial blood flow in acute and chronic digitalization.
abstract: The myocardial blood flow was measured by the 133Xenon disappearance curve from the left ventricular wall following an injection of 133Xenon in the left coronary artery in 8 dogs without digoxin pretreatment and in 8 chronically digitalized dogs. The myocardial blood flow was significantly less (30%) in the digitalized dogs than in the dogs without pretreatment. In the digitalized dogs as well as in those without pretreatment an intravenous injection of digoxin resulted in a further significant decrease of the myocardial blood flow of about 20% and a significant increase of the coronary vascular resistance. The reduced myocardial blood flow both during acute and chronic digitalization is beleived to be of clinical importance.
mesh_terms: D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects*; D003864:Depression, Chemical; D004077:Digoxin / Q000097:blood / Q000494:pharmacology*; D004285:Dogs; D006439:Hemodynamics / Q000187:drug effects; D013997:Time Factors
chemical_list: D004077:Digoxin