Interaction of vinblastine analogues with tubulin.
Studies of the interaction between vinblastine-like alkaloids and their receptor, i.e. tubulin, are reported. They shed some light on the structure-activity relationships in this medicinally important series: the configurations at C14' and C16' as well as the presence of the methoxycarbonyl group on C16' seem to play an essential role in the determination of biological activity.
D006023:Glycoproteins / Q000378:metabolism*; D013329:Structure-Activity Relationship; D014404:Tubulin / Q000378:metabolism*; D014747:Vinblastine / Q000031:analogs & derivatives / Q000378:metabolism; D014748:Vinca Alkaloids / Q000378:metabolism*; D014750:Vincristine / Q000378:metabolism
D006023:Glycoproteins; D014404:Tubulin; D014748:Vinca Alkaloids; D014750:Vincristine; D014747:Vinblastine