title: [Stability of drug resistance in staphylococci under various conditions and the effect on it of prolonged culture storage on artificial nutrient media].
abstract: The literature and experimental data on stability of resistance ot benzylpenicillin, streptomycin, tetracycline, chloramphenicol, erythromycin, kanamycin and methicillin in staphylococci stored for prolonged periods of time on artificial nutrient media were systematized. When the staphylococcal cultures were not in contact iwth the antibiotics for 5 to 18 months, sensitive cells to separate drugs were detected in 51.0--67.4 per cent of the strains. The number of such cells in the populations of some strains ranged from 1 to 100.0 per cent. The effect of the resistance multiplicity on the stability of resistance to benzylpenicillin, tetracycline, chloramphenicol and erythromycin was not observed.
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D003470:Culture Media / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D008826:Microbial Sensitivity Tests; D011309:Preservation, Biological; D013210:Staphylococcus / Q000187:drug effects*; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D003470:Culture Media
vernacular_title: Stabil'nost' lekarstvennoĭ ustoĭchivosti u stafilokokkov v razlichnykh usloviiakh i vliianie na nee dlitel'nogo khraneniia kul'tur na iskusstvennykh pitatel'nykh sredakh.