[Hormones and differentiation of retinal ganglion cells during embryogenesis of mice of the mutant line ocular retardation (karyometric study)].
Hormonal effects on differentiation of neuroblasts forming the ganglionic zone have been studied in hereditary damaged ocular retina of mice from the mutant line "ocular retardation" (or). By the method of karyometry, it has been demonstrated that injection of cortisone, triiodethyronine and somatotropic hormone on the 8--9--10th, as well as on the 11--12--13--14th or on the 9--10--11--13--14th days of gestation produce statistically significant volumetric decrease or increase of the ganglionic cell nuclei in the retina of 15-day-old embryos or/or. The data obtained and those from the literature suggest that the hormones mentioned above, depending on the dose and prenatal stage in the or/or mice, increase or decrease the inhibiting effects of the mutant gene or on the differentiation of ganglionic cells of the ocular retina in embryos.
D000818:Animals; D002454:Cell Differentiation; D002467:Cell Nucleus / Q000648:ultrastructure; D003348:Cortisone; D013006:Growth Hormone; D051379:Mice; D008818:Mice, Neurologic Mutants; D009474:Neurons / Q000648:ultrastructure; D012160:Retina / Q000002:abnormalities* / Q000166:cytology / Q000196:embryology; D014284:Triiodothyronine
D014284:Triiodothyronine; D013006:Growth Hormone; D003348:Cortisone
Gormony i differentsirovka ganglioznykh kletok setchatki glaza v émbriogeneze mysheĭ mutantnoĭ linii ocular retardation (kariometricheskoe issledovanie).