title: Sites of cerebrovascular injury induced by radiographic contrast media.
abstract: The object of this study was to determine the type of cerebral vessel affected by injection of radiopaque contrast agents used in cerebral angiography. Seventeen rabbits were prepared surgically for a left intracarotid injection of methylglucamine iothalamate (Conray 60) or methylglucamine diatrizoate (Reno-M-60). Extravasations of the tracers, Evans blue and horseradish peroxidase, occurred in the left half of the brain and occasionally in the right half. Within those areas of blood-brain barrier breakdown, the frequency of leakage was 60% for arterioles, 25% for venules, and 12% for capillaries. The leakage appeared to be primarily intercellular, rather than intracellular. This study provides evidence that greater blood-brain barrier alterations occur in arterioles and venules than in capillaries following cerebral angiography.
mesh_terms: D000818:Animals; D001158:Arteries / Q000648:ultrastructure*; D001160:Arterioles / Q000648:ultrastructure*; D001921:Brain / Q000098:blood supply*; D002533:Cerebral Angiography; D003973:Diatrizoate / Q000031:analogs & derivatives*; D003974:Diatrizoate Meglumine / Q000009:adverse effects*; D007482:Iothalamate Meglumine / Q000009:adverse effects*; D011817:Rabbits; D014680:Veins / Q000648:ultrastructure*; D014699:Venules / Q000648:ultrastructure*
chemical_list: D003973:Diatrizoate; D003974:Diatrizoate Meglumine; D007482:Iothalamate Meglumine