[Andrologic study in immunosuppressive treatment of chronic aggressive hepatitis].
By andrological and internal investigations in men with chronic aggressive hepatitis the problem is discussed, whether the therapy with Azathioprin can cause damage of the exogenous function of the testes. It would be demonstrated that within an observation time of 1720 days there have not been determined alterations of consistency and volume of the testes, sperm density and motility of spermatozoa, when the maximum of the daily dose was not more than 150 mg. Depending on the individual dose the morphology shows more pathological spermatozoa, but a direct and regular dependence could not be found. The density of spermatozoa did never decrease below values of 40 mill./ml. These results do not allow the suggestion that this cytostaticum is absolutely harmless. The main duty will always be to observe each patient currently and during a long period.
D001379:Azathioprine / Q000009:adverse effects* / Q000627:therapeutic use; D002908:Chronic Disease; D006505:Hepatitis / Q000188:drug therapy*; D006801:Humans; D008297:Male; D013081:Sperm Motility / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects*; D013094:Spermatozoa / Q000187:drug effects*; D013737:Testis / Q000187:drug effects
D001379:Azathioprine
Andrologische Untersuchungen bei der Immun-supressiv-Therapie der chronisch-aggressiven Hepatitis.