Combined antiviral effect of DNA inhibitors on adenovirus multiplication.
9 purine or pyrimidine analogues or other inhibitors of DNA synthesis were studied on their single and combined inhibitory effect on the multiplication of adenovirus 9--15 in HeLa cell cultures. The criterium of inhibition was the total suppression of the formation of infectious virus. Inhibiting concentrations were derived from isobolograms. 34 of 36 drug pairs acted in a synergistic manner, one pair showed additive and one no interaction.
D000256:Adenoviridae / Q000187:drug effects*; D000998:Antiviral Agents; D002478:Cells, Cultured; D004261:DNA Replication / Q000187:drug effects*; D004279:DNA, Viral; D003864:Depression, Chemical; D006367:HeLa Cells / Q000382:microbiology; D011687:Purines / Q000494:pharmacology*; D011743:Pyrimidines / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects*
D000998:Antiviral Agents; D004279:DNA, Viral; D011687:Purines; D011743:Pyrimidines