title: [Experiences with substitution therapy using a new pancreatic enzyme of plant origin].
abstract: The indication field of Nortase, a combination of microbial lipolytic and proteolytic enzymes, comprises the replacement therapy of maldigestion and insufficiency of pancreas. Its efficacy and tolerance were tested in 100 patients in an open study under the conditions of general practice. During the 15-day treatment the following symptoms were evaluated: anorexia, flatulence, pressure and pain in the epigastrium, nausea after the meals, belching, pyrosis, the quality of feces and the body weight. 96% of the patients showed relief of the symptoms after treatment, 65% a therapeutic result ranging from very good to good. In 53% an improvement of the quality of feces was observed and 76% reached an increase in weight. 6 patients had some small side effects, in 1 case the treatment had to be interrupted. The altogether good results confirmed the results of former investigations on the acid stability and the high lipolytic activity of lipase from Rhizopus arrhizus.
mesh_terms: D000328:Adult; D000368:Aged; D001236:Aspergillus oryzae / Q000201:enzymology; D004063:Digestion; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008049:Lipase / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010182:Pancreatic Diseases / Q000188:drug therapy*; D010936:Plant Extracts / Q000627:therapeutic use*; D010946:Plants, Medicinal / Q000201:enzymology
chemical_list: D010936:Plant Extracts; D008049:Lipase
vernacular_title: Erfahrungen bei der Substitutionstherapie mit einem neuen Pankreasferment-Präparat pflanzlicher Herkunft.