The effect of drugs on enzyme release from the hypoxic myocardium.
The leakage of enzymes from the myocardial cell can be used as an index of the onset and severity of tissue damage. A study has been carried out using the isolated perfused hypoxic rat heart in which the ability of various doses of isoprenaline, dobutamine, propranolol, glucose, insulin, mannitol, adenosine triphosphate and hydrocortisone to increase or decrease myocardial enzyme leakage has been evaluated.
D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D002395:Catecholamines / Q000494:pharmacology*; D003327:Coronary Disease / Q000201:enzymology*; D003402:Creatine Kinase / Q000378:metabolism; D004280:Dobutamine / Q000494:pharmacology*; D004734:Energy Metabolism / Q000187:drug effects; D005947:Glucose / Q000494:pharmacology*; D005950:Glucose Solution, Hypertonic / Q000494:pharmacology*; D006854:Hydrocortisone / Q000494:pharmacology*; D007328:Insulin / Q000494:pharmacology*; D007527:Isoenzymes; D007545:Isoproterenol / Q000494:pharmacology*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D007931:Leucyl Aminopeptidase / Q000378:metabolism; D008297:Male; D008353:Mannitol / Q000494:pharmacology*; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000201:enzymology*; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats
D002395:Catecholamines; D005950:Glucose Solution, Hypertonic; D007328:Insulin; D007527:Isoenzymes; D008353:Mannitol; D004280:Dobutamine; D000255:Adenosine Triphosphate; D011433:Propranolol; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase; D007931:Leucyl Aminopeptidase; D005947:Glucose; D007545:Isoproterenol; D006854:Hydrocortisone