Sensitivity of urine-grown cells of Providencia stuartii to antiseptics.
Urine-grown cultures of 23 clinical isolates of Gram-negative bacteria having a range of minimum inhibitory concentration values for chorhexidine were challenged with various concentrations of this antiseptic. The results suggest that cells of Providencia stuartii, in particular, exhibit a considerable degree of resistance to chlorhexidine under these conditions, concentrations of up to 10 000--20 000 microgram/ml of urine being necessary to produce complete loss of viability of such cultures. Of the other two antiseptics tested, phenoxyethanol proved to be the more effective, the recommended use concentration of 2% v/v producing reductions in viable counts of greater than six logarithms in all the strains examined. It is suggested that phenoxyethanol may be a suitable alternative to the cationic agents for use in antiseptic policies for bladder management of urinary tract infections with Providencia stuartii.
D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D002710:Chlorhexidine / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D005026:Ethylene Glycols / Q000494:pharmacology; D006801:Humans; D011511:Proteus / Q000187:drug effects*; D011532:Providencia / Q000187:drug effects*; D014556:Urine / Q000382:microbiology*
D000891:Anti-Infective Agents, Local; D005026:Ethylene Glycols; C005398:phenoxyethanol; D002710:Chlorhexidine