title: Caloric restriction lowers blood pressure in the spontaneously hypertensive rat.
abstract: In the spontaneously hypertensive rat (SHR), caloric restriction without sodium restriction is associated with reduced blood pressure. Four days of fasting lowered blood pressure 19% while 4 days of eating 50% of ad lib intake reduced blood pressure 10%. Similar dietary changes had less effect on blood pressure in normotensive rats of the same strain (Wistar-Kyoto--WKY). These data are consistent with the hypothesis that caloric restriction lowers sympathetic activity.
mesh_terms: D000818:Animals; D001794:Blood Pressure; D004032:Diet; D004038:Diet, Reducing; D004195:Disease Models, Animal; D002149:Energy Intake; D006973:Hypertension / Q000235:genetics / Q000503:physiopathology*; D051381:Rats