Reversal of chronic diabetes insipidus during treatment with protriptyline.
We have described a 13-year-old white boy with Ondine's curse, sleep apnea and cataplexy who simultaneously developed progressive hypothalamic neuroendocrine deficiencies requiring replacement therapy. The patient was treated with protriptyline, a nonsedating tricyclic antidepressant, for control of the sleep-related symptoms. An unexpected result was the apparent reversal of his chronic diabetes insipidus by protriptyline, necessitating discontinuation of lysine-vasopressin. Some possible mechanisms of action were discussed.
D000293:Adolescent; D002908:Chronic Disease; D003919:Diabetes Insipidus; D003986:Dibenzocycloheptenes / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011530:Protriptyline / Q000627:therapeutic use*; D012075:Remission, Spontaneous; D012893:Sleep Wake Disorders / Q000188:drug therapy*
D003986:Dibenzocycloheptenes; D011530:Protriptyline