[Acute toxicity of l-naphthyl chlorocarbonate and o-isopropoxynitrobenzene].
The investigated compounds given orally to male rats induced pathological changes mainly in the liver. 1-naphthyl chlorocarbonate caused also necrosis of the stomach mucosa. DL50 of o-isopropoxynitrobenzene and 1-naphthyl chlorocarbonate established for male rats after per os administration amounted to 2,75 g/kg and 2,55 g/kg, respectively. Both substances have local irritant effect on the skin and the eye of rabbit--a mild reaction in case of o-isopropoxynitrobenzene and strong one in case of 1-naphthyl chlorocarbonate administration. 1-naphthyl chlorocarbonate has sensitizing properties, while the other compound has not.
D000818:Animals; D002254:Carbonates / Q000276:immunology / Q000633:toxicity; D005123:Eye / Q000187:drug effects; D005753:Gastric Mucosa / Q000187:drug effects; D007928:Lethal Dose 50; D008099:Liver / Q000187:drug effects; D008297:Male; D009281:Naphthalenes / Q000633:toxicity*; D009578:Nitrobenzenes / Q000633:toxicity*; D011817:Rabbits; D051381:Rats; D012867:Skin / Q000187:drug effects
D002254:Carbonates; D009281:Naphthalenes; D009578:Nitrobenzenes; C018327:2-isopropoxynitrobenzene
Ostra toksychnośc chloromrówczanu 4-naftylu i o-izopropoksynitrobenzenu.