Adrenocortical suppression by synthetic corticosteroid drugs: a comparative study of prednisolone and betamethasone.
1 Single-dose studies were conducted to investigate the relative potency of prednisolone and betamethasone in suppressing adrenocortical function. 2 Betamethasone produced more profound suppression of plasma cortisol than an equivalent anti-inflammatory dose of prednisolone.
D000302:Adrenal Cortex / Q000187:drug effects*; D000328:Adult; D000368:Aged; D001623:Betamethasone / Q000009:adverse effects*; D003864:Depression, Chemical; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D008875:Middle Aged; D010919:Placebos; D011239:Prednisolone / Q000009:adverse effects*; D013997:Time Factors
D010919:Placebos; D001623:Betamethasone; D011239:Prednisolone; D006854:Hydrocortisone