Experiments on the mechanism of the inhibition of mitochondrial Ca2+ transport by La3+ and ruthenium red.
The effects of La3+ and ruthenium red on the energy-linked uptake of Ca2+ mediated by a synthetic neutral Ca2+ ionophore have been investigated in rat liver mitochondria. The results indicate that unspecific surface charge effects do not play a major role in the mechanism of inhibition of mitochondrial Ca2+ transport by La3+ and ruthenium red.
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D003864:Depression, Chemical; D066298:In Vitro Techniques; D007476:Ionophores / Q000494:pharmacology; D007700:Kinetics; D007811:Lanthanum / Q000494:pharmacology*; D008930:Mitochondria, Liver / Q000378:metabolism*; D051381:Rats; D012428:Ruthenium / Q000494:pharmacology*; D012430:Ruthenium Red / Q000494:pharmacology*
D007476:Ionophores; D012430:Ruthenium Red; D007811:Lanthanum; D012428:Ruthenium; D002118:Calcium