title: [Distribution, concentration and the interrelationship of free and bound tetracycline in the body of animals with multiple administrations].
abstract: When tetracycline was used for a long period of time, constant changes in the distribution regularities of free and bound fractions of the drug were observed. The changes were accompanied by a successive increase in the concentrations of both the fractions in the animal organs, tissues and fluids, as well as by a change in their levels, accumulation rate and percentage content.
mesh_terms: D000818:Animals; D001702:Biopharmaceutics; D005609:Free Radicals; D011485:Protein Binding / Q000187:drug effects; D011817:Rabbits; D013752:Tetracycline / Q000008:administration & dosage / Q000378:metabolism*; D013997:Time Factors
chemical_list: D005609:Free Radicals; D013752:Tetracycline
vernacular_title: Raspredelenie, kontsentratsiia i vzaimosviaz' svobodnogo i sviazannogo tetratsiklina v organizme zhivotnykh pri mnogokratnom ego vvedenii.