title: Influence of the phenylalanine dose on the aromatic acid excretion in phenylketonuric heterozygotes and controls after oral loading.
abstract: Heterozygotes for phenylketonuria and controls were given oral loads of 100 mg and 200 mg L-phenylalanine per kilogram body weight. The concentrations of urinary aromatic acids were determined by gas-chromatography after isolation by ion-exchange chromatography and ethylacetate extraction. On an intake of 100 mg L-phenylalanine per kilogram, controls and carriers of classical phenylketonuria excreted nearly the same amounts of aromatic acids (P greater than 0.05). However on an intake of 200 mg per kilogram L-phenylalanine they could be distinguished from one another (P less than 0.001).
mesh_terms: D006580:Genetic Carrier Screening; D006579:Heterozygote; D006801:Humans; D007773:Lactates / Q000652:urine; D008333:Mandelic Acids / Q000652:urine; D010648:Phenylacetates / Q000652:urine; D010649:Phenylalanine; D010661:Phenylketonurias / Q000652:urine*; D010667:Phenylpyruvic Acids / Q000652:urine
chemical_list: D007773:Lactates; D008333:Mandelic Acids; D010648:Phenylacetates; D010667:Phenylpyruvic Acids; D010649:Phenylalanine