Interpretation of urinary oestrogen:creatinine ratio for monitoring fetoplacental function in late pregnancy.
In pregnancies with a normal outcome the oestrogen:creatinine ratio in early morning samples of urine showed a smaller day-to-day variation than the ratio in 24-h urine or the 24-h total oestrogen excretion, and a significant fall could be detected more easily. Patients admitted to hospital who eventually delivered a healthy baby provided a reference range which, after logarithmic transformation, increased linearly with period of gestation. A fall in log10 oestrogen:creatinine ratio exceeding 40% of this range is unusual in pregnancies with a healthy outcome, and suggest impaired fetoplacental function.
D003404:Creatinine / Q000652:urine*; D004967:Estrogens / Q000652:urine*; D005260:Female; D005333:Fetus / Q000502:physiology*; D005865:Gestational Age; D006801:Humans; D008991:Monitoring, Physiologic; D010920:Placenta / Q000502:physiology*; D011247:Pregnancy; D013997:Time Factors
D004967:Estrogens; D003404:Creatinine