Inhibition of caerulein and physalaemin-induced contractions of guinea-pig isolated ileum by non-steroidal antiinflammatory drugs and various steroids and their reversal by prostaglandin E1.
Two non-steroidal antiinflammatory drugs, two antiinflammatory steroids and two sex steroids were found to potently and reversibly inhibit caerulein-induced and physalaemin-induced contractions of guinea-pig isolated ileum. The effects of these drugs were reversed by small amounts of PGE1.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001623:Betamethasone / Q000494:pharmacology; D002108:Ceruletide / Q000494:pharmacology*; D004336:Drug Antagonism; D005260:Female; D012739:Gonadal Steroid Hormones / Q000494:pharmacology; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D007705:Kinins / Q000494:pharmacology*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D010803:Physalaemin / Q000494:pharmacology*; D011239:Prednisolone / Q000494:pharmacology; D011458:Prostaglandins E / Q000494:pharmacology*; D013256:Steroids / Q000494:pharmacology*
D000893:Anti-Inflammatory Agents; D012739:Gonadal Steroid Hormones; D007705:Kinins; D011458:Prostaglandins E; D013256:Steroids; D010803:Physalaemin; D002108:Ceruletide; D001623:Betamethasone; D011239:Prednisolone