[Changes in the composition of heart proteins during early ontogenesis in normal subjects and in the presence of reduced uteroplacental blood flow].
The heart was studied on the 11th, 12th, 14th, 16th and 18th days of the rabbit embryo development under normal conditions and in decreased uteroplacental circulation. Under normal conditions the heart weight/embryo weight ratio was particularly high during the intensive development of hemodynamic functional "embryo -- placenta -- uterus" system (on the 12th and the 14th day), and then this ratio decreased. An increase of the total heart nitrogen and alterations in fractional composition on account of increase of contractile proteins and stroma proteins was particularly high by the 18th day. In pathology a decrease of the embryo and heart weights was noted in the course of all the days of the experiment. By the 18th day the heart/embryo weight ratio suggested the beginning of spontaneous rehabilitation due to gradual increase of the uteroplacental circulation. However, the total nitrogen in the heart in all the test groups remained the same as in control or increased, this pointing to the heart dehydration. Changes in the fractional composition of the heart proteins indicated deep biochemical disorders in it, and this could serve as one of the causes of the heart functional derangement.
D000818:Animals; D002682:Chinchilla; D005260:Female; D005318:Fetal Heart / Q000032:analysis*; D005865:Gestational Age; D008431:Maternal-Fetal Exchange; D009124:Muscle Proteins / Q000032:analysis*; D009929:Organ Size; D010920:Placenta / Q000098:blood supply; D010922:Placenta Diseases / Q000378:metabolism*; D010927:Placental Insufficiency / Q000378:metabolism*; D011247:Pregnancy; D011817:Rabbits; D014599:Uterus / Q000098:blood supply
D009124:Muscle Proteins
Izmeneniia sostava belkov serdtsa v rannem ontogeneze v norme i v usloviiakh umen'shennogo matochno-platsentarnogo krovotoka.