Use of guinea pigs as model to study galactose-induced cataract formation.
Because the dietary requirement for ascorbic acid is similar in humans and guinea pigs, galactose-induced cataract research with the guinea pig as an experimental model instead of the rat might be appropriate and may represent a closer analogy to galactosemic cataract formation in humans. In this study, dietary ascorbic acid was found in all guinea pigs to have a retarding or delaying effect on the development of galactose-induced cataracts.
D000818:Animals; D001205:Ascorbic Acid / Q000502:physiology; D002386:Cataract / Q000209:etiology* / Q000517:prevention & control; D004032:Diet; D004195:Disease Models, Animal; D005693:Galactosemias / Q000150:complications*; D006168:Guinea Pigs / Q000378:metabolism*
D001205:Ascorbic Acid