The isolation and structure of 13,18-dehydroglaucarubinone, a new antineoplastic quassinoid from Simarouba amara.
An investigation of the Guyana plant Simarouba amara Aubl. (Simaroubaceae) for antineoplastic quassinoids led to isolation and structural determination of the new quassinoids 2'-acetylglaucarubine (1a) and 13,18-dehydroglaucarubinone (2). The previously known 2'-acetylglaucarubinone (3a) and glaucarubinone (3b) were also obtained. The new quassinoid 2 was found significantly to inhibit growth of the murine lymphocytic leukemia P388.
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000627:therapeutic use; D005900:Glaucarubin / Q000031:analogs & derivatives; D009374:Neoplasms, Experimental / Q000188:drug therapy; D008517:Phytotherapy; D010946:Plants, Medicinal / Q000032:analysis; D013329:Structure-Activity Relationship
D000972:Antineoplastic Agents, Phytogenic; C018259:13,18-dehydroglaucarubinone; D005900:Glaucarubin