Glass formation in barbiturates and solid dispersion systems of barbiturates with citric acid.
Glasses were prepared from a number of barbiturates. The viscosities and glass transition temperatures of the glasses were dependent on the structure of the groups present on the C-5 and N-1 atoms. Solid dispersions were prepared from three selected barbiturates formulated with citric acid. The glass transition temperatures of these systems indicated that a 1:1 molar ratio complex was formed between the two components and that intermolecular bonding was stronger in the complex than in the individual components.
D001463:Barbiturates; D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical; D002627:Chemistry, Physical; D002951:Citrates; D012995:Solubility; D013535:Suspensions; D013816:Thermodynamics; D014961:X-Ray Diffraction
D001463:Barbiturates; D002951:Citrates; D013535:Suspensions