title: [Antibiotic prophylaxis in plastic reconstructive surgery].
abstract: In plastic reconstructive surgery the use of prophylactic antibiotics is considered for wounds in which tissue trauma can not exactly be delineated as in gun shot wounds, bites, contusions; for extensive surgery lasting more than three hours in the oral area, with opening of the maxillary sinuses; when large foreign bodies are implanted; if there is massive intraoperative contamination and for patients with reduced antibacterial defence mechanisms. A principal factor leading to infection is reduced tissue oxygenation, which can be reversed by the use of benzopyrones as experimentally demonstrated.
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000517:prevention & control*; D006801:Humans; D011753:Pyrones / Q000627:therapeutic use; D012965:Sodium Chloride / Q000627:therapeutic use; D013518:Surgery, Plastic; D013530:Surgical Wound Infection / Q000517:prevention & control*
chemical_list: D000900:Anti-Bacterial Agents; D011753:Pyrones; D012965:Sodium Chloride
vernacular_title: Antibiotikaprophylaxe in der plastischen Wiederherstellungschirurgie?