[Effect of triterpene glycosides on the biosynthesis of sterols and fatty acids by the yeast Saccharomyces carlsbergensis].
The effect of cauloside C from Caulophyllum robustum M., theasaponine from Thea sinensis L. and stichoposide A from Stichopus japonicus S. on the biosynthesis of sterols and fatty acids by the yeast Saccharomyces carlsbergensis was studied. In in vivo and in vitro experiments cauloside C and theasaponine inhibited ergosterol biosynthesis at the stage of squalene-to-lanosterol transformation. In in vivo experiments stichoposide A inhibited squalene biosynthesis. The triterpene glycosides tested showed a typical feature: in in vivo and in vitro experiments they blocked the biosynthesis of fatty acids.
D004875:Ergosterol / Q000096:biosynthesis; D005227:Fatty Acids / Q000096:biosynthesis*; D005960:Glucosides / Q000494:pharmacology; D006027:Glycosides / Q000494:pharmacology; D009828:Oleanolic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D010840:Phytosterols / Q000096:biosynthesis*; D012440:Saccharomyces / Q000187:drug effects / Q000378:metabolism*; D013185:Squalene / Q000096:biosynthesis; D014315:Triterpenes / Q000494:pharmacology*
D005227:Fatty Acids; D005960:Glucosides; D006027:Glycosides; D010840:Phytosterols; D014315:Triterpenes; D009828:Oleanolic Acid; D013185:Squalene; C018245:cauloside C; D004875:Ergosterol
Bliianie nekotorykh triterpenovykh glikozidov na biosintez sterinov i zhirnykh kislot drozhzheĭ Saccharmyces carlsvergensis.