Mode of action of gentamicin antibiotics produced by Micromonospora purpurea.
Gentamicin antibiotics were produced fermentatively by Micromonospora purpurea. They were separated into gentamicin C1, C1a and C2 by paper chromatographic technique, using chloroform, methanol, and 17.0% of NH4OH (2: 1: 1 v/v) as developing solvent. The different antibiotics showed variable antimicrobial activities. The gentamicin antibiotics inhibited the biosynthesis of DNA and RNA of the proteins, present in the cells of Staphylococcus aureus.
D001419:Bacteria / Q000187:drug effects; D004269:DNA, Bacterial / Q000096:biosynthesis; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D005839:Gentamicins / Q000096:biosynthesis / Q000494:pharmacology*; D008847:Micromonospora / Q000378:metabolism*; D010750:Phosphoproteins / Q000096:biosynthesis; D012329:RNA, Bacterial / Q000096:biosynthesis; D013045:Species Specificity; D013211:Staphylococcus aureus / Q000187:drug effects / Q000378:metabolism
D004269:DNA, Bacterial; D005839:Gentamicins; D010750:Phosphoproteins; D012329:RNA, Bacterial