Age related differences in the disposition of acetanilide.
1 The metabolism of fifteen elderly hospital in-patients and fifteen young people was studied, using a gas chromatography mass spectrometer method. 2 The results suggest that there is no significant change in hepatic oxidation of acetanilide with age. 3 The concentrations of metabolites were however, significantly elevated in the older group. 4 These results illustrate the importance of the decline in renal function with age in the disposition of drugs.
D000083:Acetanilides / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000375:Aging; D001711:Biotransformation; D002849:Chromatography, Gas; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D013058:Mass Spectrometry
D000083:Acetanilides