title: Effect of 5-bromodeoxyuridine on differentiation. II. The effect of early BUdR treatment on gastrulation of sea urchin embryos.
abstract: BUdR treatment of early cleavage stages is more effective on gastrulation the earlier the drug is administered before the 16-cell stage. The distribution of percentages of embryos gastrulating is in good agreement with the theoretical calculated values presented in part I and permit the assumption that BUdR may act by preventing normal transcription at, or shortly after, the 16-cell stage.
mesh_terms: D000818:Animals; D001973:Bromodeoxyuridine / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects*; D005855:Germ Layers / Q000166:cytology*; D012617:Sea Urchins; D013997:Time Factors; D014158:Transcription, Genetic / Q000187:drug effects
chemical_list: D001973:Bromodeoxyuridine