Association of 5q- and refractory anemia.
The association of refractory anemia with partial deletion of the long arm of one No. 5 chromosome (5q-) has been reported in six patients within the last two years. We wish to report an additional patient with refractory anemia and an acquired chromosomal deletion, del(5)(q15), in a direct bone-moarrow preparation. The specificity of this deletion for refractory anemia is discussed. It remains to be seen whether patients with refractory anemia and 5q- tend to develop acute leukemia, as has been recently suggested.
D000208:Acute Disease; D000741:Anemia, Aplastic / Q000150:complications / Q000235:genetics*; D002871:Chromosome Banding; D002872:Chromosome Deletion; D002905:Chromosomes, Human, 4-5; D005260:Female; D006801:Humans; D007938:Leukemia / Q000209:etiology; D008875:Middle Aged