[Effect of hydrocortisone on the sodium and potassium content and distribution in rat hippocampus sections].
Slices of the rat hyppocampus (CA2 region) were incubated in blood plasma, and the content of Na and K in them, and also distribution of these elements in the extra- and intracellular space (by the inulin method) after hydrocortisone (HC) administration was investigated. Special morphological studies had shown that the first slices embraced the dense neuron cell bodies layer; the next slices (deeper ones) had much less neurons. A single dose of HC given 3 hours before the experiment in doses of 1 and 5 mg per 100 g of body weight caused a decrease of intracellular Na concentration and an increase of intracellular K in the first slices; the transmembrane distribution coefficient was elevated for both ions. After 7-day HC administrattion the changes described practically disappeared. The second slices (having only a few neuron cell bodies) showed no significant changes in the electorlyte composition in all the experiments conducted.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism; D006854:Hydrocortisone / Q000494:pharmacology*; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D011188:Potassium / Q000378:metabolism*; D051381:Rats; D012964:Sodium / Q000378:metabolism*; D013997:Time Factors
D012964:Sodium; D011188:Potassium; D006854:Hydrocortisone
Vliianie gidrokortizona na soderzhanie i raspredelenie natriia i kaliia v srezakh gippokampa krys.