Pressure reversal of general anaesthesia--a multi-site expansion hypothesis.
We have quantitated the pressure reversal of continuous i. v. anaesthesia produced in rats by ketamine, methohexitone, propanidid and thiopentone. These and other data are not consistent with the earlier critical volume hypothesis of general anaesthesia and therefore we postulate an alternative molecular mechanism--the multi-site expansion hypothesis.
D000771:Anesthesia, Intravenous; D000818:Animals; D004305:Dose-Response Relationship, Drug; D007649:Ketamine / Q000494:pharmacology; D008297:Male; D008433:Mathematics; D008723:Methohexital / Q000494:pharmacology; D008954:Models, Biological; D011312:Pressure; D011410:Propanidid / Q000494:pharmacology; D051381:Rats; D013874:Thiopental / Q000494:pharmacology; D013997:Time Factors
D007649:Ketamine; D011410:Propanidid; D008723:Methohexital; D013874:Thiopental