Effects of low calcium and low phosphorus diets on the duodenal absorption of calcium in betamethasone-treated chicks.
The effect of oral administration of betamethasone (25 microgram kg-1 day-1) on the duodenal absorption of calcium has been studied in chicks using the ligated loop technique in vivo. The chicks were fed normal calcium, normal phosphorus (NCaNP), low calcium, normal phosphorus (LCaNP) or normal calcium, low phosphorus (NCaLP) diets. Daily oral administration of betamethasone for 2-3 weeks markedly reduced the absorption of calcium in chicks fed the NCaNP diet, but did not significantly affect the adaptation in absorption when the NCaLP or LCaNP diets were fed for the same period of time. In one group of chicks, betamethasone was administered daily for 10 days before the birds were transferred to the NCaLP or LCaNP diets. Adaptation was again unaffected by betamethasone treatment. Administration of betamethasone caused a marked retardation in growth-rate, hypercalcaemia and an increased percentage of ash in the tibiae.
D000818:Animals; D001623:Betamethasone / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism*; D002136:Calcium, Dietary / Q000378:metabolism; D002645:Chickens; D004032:Diet; D004386:Duodenum / Q000378:metabolism; D007408:Intestinal Absorption / Q000187:drug effects*; D010758:Phosphorus / Q000378:metabolism
D002136:Calcium, Dietary; D010758:Phosphorus; D001623:Betamethasone; D002118:Calcium