Toxicity of combined therapy with carbonic anhydrase inhibitors and aspirin.
A 67-year-old woman and a 75-year-old woman taking carbonic anhydrase inhibitors for therapy of glaucoma and high doses of aspirin for therapy of arthritis developed severe acid-base imbalance and salicylate intoxication. Neither patient exhibited ill effects when taking high aspirin doses without carbonic anhydrase inhibitor. Carbonic anhydrose inhibitor-induced acidemia increases the risk of developing salicylate intoxication in patients receiving high aspirin doses.
D000086:Acetazolamide / Q000009:adverse effects / Q000627:therapeutic use; D000137:Acid-Base Imbalance / Q000209:etiology* / Q000628:therapy; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D001241:Aspirin / Q000009:adverse effects* / Q000627:therapeutic use; D002257:Carbonic Anhydrase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D004357:Drug Synergism; D005260:Female; D005901:Glaucoma / Q000188:drug therapy; D006801:Humans
D002257:Carbonic Anhydrase Inhibitors; D000086:Acetazolamide; D001241:Aspirin