The evaluation of topical anti-inflammatory activity on rat ears subjected to thermal injury.
Topical anti-inflammatory activity of steroidal and non-steroidal agents was assessed on inflammation produced by heat. A burn was produced on the ears of rats and the inflammation was quantitated gravimetrically. Steroidal anti-inflammatory agents were ranked in order of decreasing activity: triamcinolone acetonide, dexamethasone, prednisolone and hydrocortisone acetate. The nonsteroidal agents phenylbutazone and indomethacin were also effective in inhibiting the inflammation. Cholesterol, a steroid devoid of anti-inflammatory activity, was inactive in this test. Hydrocortisone acetate, in particular, appears to be less effective in inhibiting this type of inflammation than inflammation produced by croton oil.
D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002056:Burns / Q000188:drug therapy*; D003907:Dexamethasone / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D006854:Hydrocortisone; D007213:Indomethacin / Q000627:therapeutic use; D010653:Phenylbutazone / Q000627:therapeutic use; D011239:Prednisolone; D051381:Rats; D014222:Triamcinolone Acetonide / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D003907:Dexamethasone; D011239:Prednisolone; D014222:Triamcinolone Acetonide; D010653:Phenylbutazone; D006854:Hydrocortisone; D007213:Indomethacin