Estriol antagonism of the action of bradykinin and adrenalin on human umbilical artery.
The effect of estriol on the response of human umbilical artery to bradykinin (0.2 microgram/ml) and adrenalin (0.8 microgram/ml) was studied by an in vitro perfusion method. Estriol (10 microgram/ml) added to the nutrient medium decreased the response of the preparation to the two vasoactive agents. The results suggest the participation of estriol as a modulator of the vascular response at the level of the umbilical circulation, where it may act to protect the maternal-fetal circulatory system from physical or chemical stimuli.
D001920:Bradykinin / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D004837:Epinephrine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D004964:Estriol / Q000494:pharmacology*; D006801:Humans; D007231:Infant, Newborn; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010477:Perfusion; D014469:Umbilical Arteries / Q000187:drug effects*; D014666:Vasomotor System / Q000187:drug effects
D004964:Estriol; D001920:Bradykinin; D004837:Epinephrine