Psychological factors in susceptibility to drug-induced extrapyramidal symptoms.
In an effort to identify nonneurobiologic factors in the susceptibility to neuroleptic-induced extrapyramidal symptoms (EPS), the EPS response in 20 patients was correlated with field dependence, self-object differentiation, and premorbid social competence. Only the last proved to be a good predictor, which suggests that psychosocial factors play a role in a patient's EPS response.
D000328:Adult; D001480:Basal Ganglia Diseases / Q000139:chemically induced* / Q000523:psychology; D002746:Chlorpromazine / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D004409:Dyskinesia, Drug-Induced / Q000209:etiology / Q000523:psychology; D005260:Female; D005364:Field Dependence-Independence; D006801:Humans; D008297:Male; D008875:Middle Aged; D011581:Psychological Tests; D012559:Schizophrenia / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D012917:Social Adjustment
D002746:Chlorpromazine