Suppression of the immune response in C3H/HeJ mice by protein-free lipopolysaccharides.
The experiments described herein demonstrate the plaque-forming cell response of C3H/HeJ mice can be suppressed by a Boivin type lipopolysaccharide (LPS) and a deproteinized glycolipid. Suppression was observed both in vivo and in vitro, and could be transferred to normal cells in coculture experiments. This newly discovered effect of LPS in C3H/HeJ mice indicates that the adjuvant and inhibitory action of LPS may be distinct phenomena which are under different genetic regulation. Thus, the C3H/HeJ strain provides a convenient animal model for study of immunosuppression independent of the adjuvant effect.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D001427:Bacterial Toxins / Q000494:pharmacology; D004731:Endotoxins / Q000494:pharmacology; D006017:Glycolipids / Q000494:pharmacology; D007165:Immunosuppression Therapy; D008070:Lipopolysaccharides / Q000494:pharmacology*; D051379:Mice; D008809:Mice, Inbred C3H / Q000276:immunology*; D013329:Structure-Activity Relationship
D001427:Bacterial Toxins; D004731:Endotoxins; D006017:Glycolipids; D008070:Lipopolysaccharides