Aramycin, a streptothricin-like antibiotic, produced by a local strain of Streptomyces MYS-20A.
One strain of actinomycetes, designated as MYS-20 A, was isolated from the Egyptian soil. The organism produces a substance that appears to be different from previously described antibiotics. The substance was named "Aramycin". A description of the strain of actinomyces MYS 20 A is given as well as conditions of growth for maximum production of the antibiotic substance. The bacterial and fungal spectra of aramycin are given. The substance appears to exhibit a very significant cytotoxic effect. The antibiotic was toxic to mice, the lethal dose being, however, about 15 times higher than the curative dose.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000494:pharmacology / Q000633:toxicity; D001419:Bacteria / Q000187:drug effects; D004534:Egypt; D005658:Fungi / Q000187:drug effects; D051379:Mice; D010452:Peptide Biosynthesis; D010455:Peptides / Q000494:pharmacology / Q000633:toxicity; D012988:Soil Microbiology; D013045:Species Specificity; D013302:Streptomyces / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D010455:Peptides