title: The effects of some methyl prostaglandin derivatives on the ductus arteriosus of swine in vivo.
abstract: Three methylated analogues of prostaglandin E1 and E2 were examined for their ability to open the ductus arterious of neonatal piglets in vivo. Fifteen (S) 15 methyl prostaglandin E1 (15-Me PGE1), 15 (S) 1K methyl prostaglandin E2 (15-Me PGE2), and 16' 16' dimethyl prostaglandin E1 (16-diMe PGE1) all opened the ductus when given intravenously, intramuscularly or orally. The effects on ductal patency lasted four hours or more in many instances. Side-effects included apnea with intravenous and intramuscular dosages, and with high oral dosages of 15-Me PGE1. A transient drop in heart rate and blood pressure occurred with each dose. In one animal the ductus was kept open for 19 days with six-hourly intramuscular injections of 3 microgram/kg 15-Me PGE1. Transient sedation occurred with each dose. Death occurred on the 19th day and histological studies showed that the morphology of the ductus wall was similar to that seen in a two day old animal. These studies suggest that maintenance od ductal patency in the infant may be possible with oral administration of methyl prostaglandin derivatives.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000831:Animals, Newborn; D001794:Blood Pressure / Q000187:drug effects; D004373:Ductus Arteriosus / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000187:drug effects*; D004374:Ductus Arteriosus, Patent / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000473:pathology; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D011459:Prostaglandins E, Synthetic / Q000008:administration & dosage / Q000494:pharmacology*; D011674:Pulse / Q000187:drug effects; D011859:Radiography; D013552:Swine
chemical_list: D011459:Prostaglandins E, Synthetic