title: [Change of diphenylhydantoin tolerance at the time of reaching puberty in a 16-year-old girl suffering from epilepsy].
abstract: During a 3-year period of treatment with DPH three episodes of drug intolerance developed in a 16-year-old epileptic girl. The dose tolerated previously was 200 mg daily. The authors stress the effect of hormonal disturbances on the change in DPH tolerance.
mesh_terms: D000293:Adolescent; D004361:Drug Tolerance; D004827:Epilepsy / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008575:Meniere Disease / Q000139:chemically induced; D009759:Nystagmus, Pathologic / Q000139:chemically induced; D010672:Phenytoin / Q000627:therapeutic use / Q000633:toxicity*; D011627:Puberty; D014717:Vertigo / Q000139:chemically induced
chemical_list: D010672:Phenytoin
vernacular_title: Zmiana tolerancji na dwufenylhydantoine w okresie pokwitania u 16-letniej chorej na padaczke