[Genetic-biochemical analysis of the shuttle-box behavior of 2 inbred strains of mice differing in brain protein S-100 content. I. Neurospecific protein S-100 and learning].
A hybridological analysis of a mode of inheritance of two characters: biochemical (brain S-100 protein level) and behavioral (rate of active avoidance conditioned reflex formation in a shuttle box), in mice of inbred strains DBA/2J and AKR/J characterized by respectively high and low levels of these characters. The high concentration of water soluble S-100 protein in whole brain is a recessive character. The inheritance of total S-100 protein in whole brain and of the level of its water soluble fraction in brain cortex and hippocampus is complex. In all hybrids of a given couple of parents from different strains, dominance and over-dominance of a low rate of the formation of the conditioned reflex takes place. No sex differences in the avoidance level were found. Neurospecific S-100 protein content correlates positively with the rate of active avoidance conditioned reflex formation.
D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D001921:Brain / Q000502:physiology*; D001923:Brain Chemistry; D003214:Conditioning, Classical / Q000502:physiology; D005260:Female; D006824:Hybridization, Genetic; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009418:S100 Proteins / Q000032:analysis / Q000235:genetics* / Q000502:physiology; D012737:Sex Factors; D013045:Species Specificity
D009419:Nerve Tissue Proteins; D009418:S100 Proteins
Genetiko-biokhimicheskiĭ analiz povedeniia v chelnochnoi kamere mysheĭ dvukh inbrednykh liniĭ, kontrastno razlichaiushchikhsia po soderzhaniiu belka S-100 v golovnom mozge. Soobshchenie I. Neirospetsificheskiĭ belok S-100 i obuchenie.