Immunological investigations in post-traumatic granulomatous and non-granulomatous uveitis.
Histopathological and immunological investigations have been performed in 16 cases of post-traumatic granulomatous (10) and non-granulomatous uveitis (6). Most cases of sympathetic ophthalmitis showed evidence of cell mediated immunity to uveoretinal antigens, though it was not possible to make a definitive diagnosis on immunological grounds alone. Three patients with post-traumatic non-granulomatous uveitis showed a positive immunological response to ocular antigens, and 2 of these later developed clinical evidence of sympathetic ophthalmitis, which suggests that post-traumatic non-granulomatous uveitis in such cases may represent a presympathetic (i.e., incipient) or modified stage of the disease.
D000941:Antigens; D001323:Autoantibodies / Q000032:analysis; D005131:Eye Injuries / Q000150:complications*; D006099:Granuloma / Q000209:etiology / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D007136:Immunoglobulins / Q000032:analysis; D009879:Ophthalmia, Sympathetic / Q000276:immunology; D012160:Retina / Q000276:immunology; D014602:Uvea / Q000276:immunology; D014605:Uveitis / Q000209:etiology / Q000276:immunology*
D000941:Antigens; D001323:Autoantibodies; D007136:Immunoglobulins