Thymus-dependent cytokinetics in transplantable leukemia of AKR mice.
Perinatally thymectomized AKR mice inoculated i.v. with acute lymphoblastic T-cell leukemia (TAL) demonstrated, as compared to controls, an accelerated passage of injected cells through the lungs. Later in disease they also exhibited an especially intense infiltration of liver and spleen by leukemic blasts proliferating at a slow rate the big majority of cells being in the G0 + G1-phase. The thymus controls the proliferation and the traffic of leukemic cells in the recipient.
D000818:Animals; D005260:Female; D007700:Kinetics; D007942:Leukemia, Experimental / Q000473:pathology*; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D009368:Neoplasm Transplantation; D013934:Thymectomy; D013950:Thymus Gland / Q000502:physiology*; D014184:Transplantation, Homologous