Basophilic leukemia presenting as gastroduodenal ulceration: effect of H-2-receptor blockade.
A patient with multiple gastroduodenal ulcers and gastric hypersecretion due to histamine excess associated with basophilic leukemia is described. Treatment with the histamine H-2-receptor blocker, cimetidine, was able to abolish the gastric hypersecretion and gastrointestinal blood loss. A literature review produced four other cases of multiple gastroduodenal ulceration with this disease, suggesting that it is more common than previously recognized. The availability of a potent H-2-receptor antagonist offers effective and specifically tailored therapy to counteract the gastrointestinal effects of hyperhistaminemia in basophilic leukemia and other "histamine excess" diseases.
D000328:Adult; D001491:Basophils; D002927:Cimetidine / Q000627:therapeutic use*; D003937:Diagnosis, Differential; D005750:Gastric Juice / Q000187:drug effects / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism; D006146:Guanidines / Q000627:therapeutic use*; D006632:Histamine / Q000378:metabolism; D006801:Humans; D007938:Leukemia / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000175:diagnosis*
D006146:Guanidines; D002927:Cimetidine; D006632:Histamine