Anti-inflammatory effect of sialic acid.
Sialic acid was shown to possess anti-inflammatory properties as measured by carrageenan-induced rat paw oedema and pleurisy tests. As the number of leukocytes mobilized was significantly reduced it was concluded that the inhibitory effect of sialic acid on leukocyte accumulation is responsible for the inhibition of exudate/oedema formation.
D000818:Animals; D000893:Anti-Inflammatory Agents; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000503:physiopathology; D008297:Male; D009504:Neutrophils / Q000187:drug effects; D010998:Pleurisy / Q000139:chemically induced / Q000503:physiopathology; D051381:Rats; D012794:Sialic Acids / Q000494:pharmacology*
D000893:Anti-Inflammatory Agents; D012794:Sialic Acids; D002351:Carrageenan