title: Computer simulated discharges of thalamic ventrobasal neurones during sleep and wakefulness.
abstract: A theoretical model is described which in response to combinations of poissonian pulse trains with different mean frequencies on three independent incoming lines, generated output signals simulating spontaneous discharges of thalamic ventrobasal (VB) neurones during sleep and wakefulness. Some dynamic neuronal properties as refractoriness, facilitation, short term memory were simulated and characteristics of response to single pulses on different lines properly selected to reproduce those exhibited by VB neurones upon artificial stimulation of thalamic afferent systems. The data obtained from the model are briefly discussed in relation to possible contributions of specific and nonspecific afferent systems in producing spontaneous VB discharges characteristic of different levels of vigilance.
mesh_terms: D000200:Action Potentials; D000344:Afferent Pathways / Q000502:physiology; D003201:Computers; D006801:Humans; D008564:Membrane Potentials; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology; D012890:Sleep / Q000502:physiology*; D013570:Synaptic Membranes / Q000502:physiology; D013787:Thalamic Nuclei / Q000502:physiology; D013788:Thalamus / Q000502:physiology*; D013997:Time Factors; D014851:Wakefulness / Q000502:physiology*