Influence of GABA receptor agonists and antagonists on the binding of 3H-diazepam to the benzodiazepine receptor.
The GABA receptor agonists, GABA and muscimol, increased, while the GABA receptor antagonist, (+)-bicuculline, decreased the affinity of the benzodiazepine receptor for 3H-diazepam. The effect was seen at both 0 and 25 degrees C in spite of a large difference of affinity for 3H-diazepam at the two temperatures.
D000818:Animals; D001569:Benzodiazepines / Q000378:metabolism*; D001640:Bicuculline / Q000494:pharmacology; D001921:Brain / Q000378:metabolism; D003975:Diazepam / Q000378:metabolism; D018756:GABA Antagonists; D066298:In Vitro Techniques; D009118:Muscimol / Q000494:pharmacology; D051381:Rats; D011955:Receptors, Drug / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism* / Q000494:pharmacology
D018756:GABA Antagonists; D011955:Receptors, Drug; D001569:Benzodiazepines; D009118:Muscimol; D005680:gamma-Aminobutyric Acid; D003975:Diazepam; D001640:Bicuculline