Recovery of the hepatic drug-metabolizing capacity in mice infected with Schistosoma mansoni following curative chemotherapy with the schistosomicide 4-isothiocyano-4'-nitro-diphenylamine (CGP 4540).
Treatment of mice infected with Schistosoma mansoni with a single oral dose of formulated 4-isothiocyano-4'-nitro-diphenylamine (CGP 4540) restored the capacity of the liver of these animals to metabolize certain drugs. Full recovery required 35-40 weeks. Administration of CGP 4540 to non-infected animals produced no significant changes in the activities of some hepatic drug-metabolizing enzymes.
D000814:Aniline Compounds / Q000627:therapeutic use*; D000818:Animals; D004159:Diphenylamine / Q000031:analogs & derivatives / Q000627:therapeutic use*; D005260:Female; D017879:Isothiocyanates; D008099:Liver / Q000378:metabolism*; D008109:Liver Diseases, Parasitic / Q000188:drug therapy / Q000378:metabolism; D051379:Mice; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D012550:Schistosoma mansoni; D012552:Schistosomiasis / Q000188:drug therapy* / Q000378:metabolism; D012556:Schistosomicides / Q000627:therapeutic use*; D013861:Thiocyanates / Q000627:therapeutic use*
D000814:Aniline Compounds; D017879:Isothiocyanates; D004364:Pharmaceutical Preparations; D012556:Schistosomicides; D013861:Thiocyanates; D004159:Diphenylamine; C012391:amoscanate