Achalasia in father and son.
Achalasia has not been previously reported in father and son. A man, age 38, and his father, age 66, presented two years apart with symptoms of dysphagia and aspiration. The diagnosis of achalasia was made on the basis of x-ray and endoscopic findings and on esophageal motility studies performed on the father. Both responded well to pneumatic dilatation and have been asymptomatic for 24 months and 6 months, respectively. These cases again suggest a genetic basis for achalasia.
D000328:Adult; D000368:Aged; D004931:Esophageal Achalasia / Q000000981:diagnostic imaging / Q000235:genetics*; D005808:Genes, Recessive; D006801:Humans; D008297:Male; D011859:Radiography