[Biochemical study of nucleic acids of placenta and fetal liver and caryometric of trophoblastic giant cells and fetal hepatocytes of Rattus norvegicus albinus, during action of sodium 1-phenyl-2, 3-dimethyl-5-pyrazolon-methane sulfonate (Dipyrone) (author's transl)].
Female pregnant rats of 2BAW strain were divided in 2 groups: the 1st, received 50 mg/kg corporal weight of sodium 1-phenyl-2,3-dimethyl-5-pyrazolon-4-methylamino-methane sulfonate (Dipyrone), single dose daily, by i.p. injections, from 16th to 20th day of pregnancy; the 2nd, received 0,5 ml of distilled water, single dose daily, by i.p. injections, during the same period. All the animals were sacrificed 2 hours after the last injection. The biochemical results of nucleic acids in the placentas and fetal livers, and the caryometric data of trophoblastic giant cells and fetal hepatocytes, demonstrated that: 1. When compared the 2 groups, as much the nucleic acids levels (RNA and DNA) of placentas as the nuclear size of trophoblastic giant cells, do not presented statistical differences; 2. The biochemical levels of nucleic acids (RNA and DNA) of fetal livers decreased, while the nuclear size of hepatocytes increased in the experimental group, with reference to control group.
D000632:Aminopyrine / Q000031:analogs & derivatives*; D000818:Animals; D004247:DNA / Q000378:metabolism*; D004177:Dipyrone / Q000494:pharmacology*; D005260:Female; D005333:Fetus / Q000378:metabolism*; D007620:Karyometry; D008099:Liver / Q000166:cytology / Q000378:metabolism*; D008431:Maternal-Fetal Exchange; D010920:Placenta / Q000166:cytology / Q000378:metabolism*; D011247:Pregnancy; D012313:RNA / Q000378:metabolism*; D051381:Rats
D000632:Aminopyrine; D012313:RNA; D004177:Dipyrone; D004247:DNA
Estudo bioquímico dos ácidos nucléicos da placenta e do fígado fetal e cariométrico das células gigantes trofoblásticas e dos hepatócitos fetais de Rattus norvegicus albinus, sob o efeito da 1-fenil-2,3-dimetil-5-pirazolona-4-metilamino-metanossulfato de sódio (Dipirona).