[Mechanisms of the immunodepression caused by ortho-aminoazotoluene and its noncarcinogenic analog in mice].
Single injections of ortho-aminoazotoluene (OAT) or aminoazobenzene (AB) decrease the immune response of DD mice to the strain-nonspecific Krebs-2 tumor. The immunosuppressive action of AB is due to its toxicity for lymphoid cells, whereas the OAT effect is mediated by adrenal glands. After OAT injection,II-oxycorticosteroids level is elevated although their production by adrenal glands is not increased. The accumulation of glucocorticoids in blood after OAT injection is assumed to be the result of a decreased hormone utilization because of the blockade of receptor proteins or metabolizing enzymes in liver cells by a carcinogen.
D015062:11-Hydroxycorticosteroids / Q000097:blood; D000818:Animals; D001391:Azo Compounds / Q000276:immunology*; D002287:Carcinoma, Krebs 2 / Q000276:immunology; D007114:Immunization; D007165:Immunosuppression Therapy; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation; D013950:Thymus Gland / Q000187:drug effects; D013997:Time Factors; D009762:o-Aminoazotoluene / Q000276:immunology*; D010128:p-Aminoazobenzene / Q000276:immunology*
D015062:11-Hydroxycorticosteroids; D001391:Azo Compounds; D010128:p-Aminoazobenzene; D009762:o-Aminoazotoluene
Mekhanizmy immunodepresii, vyzvaemoĭ u mysheĭ u mysheĭ orto-aminoazotoluolom i ego nekantserogennym analogom.