Penetration of methicillin, oxacillin, and cephalothin into bone and synovial tissues.
The penetrations of methicillin, oxacillin, and cephalothin into cortical bone and synovial tissues were studied 1 h after their intravenous administration in 105 patients having arthroplasty of the hip. Although the lowest serum levels were noted with cephalothin (P < 0.01), more patients receiving cephalothin achieved osseous drug levels inhibitory to staphylococci (P < 0.01). Differences in the penetration of the three agents into synovial tissues were not statistically significant.
D001842:Bone and Bones / Q000378:metabolism*; D002512:Cephalothin / Q000097:blood / Q000378:metabolism*; D006621:Hip Joint / Q000601:surgery; D006801:Humans; D007595:Joint Prosthesis; D008712:Methicillin / Q000097:blood / Q000378:metabolism*; D010068:Oxacillin / Q000097:blood / Q000378:metabolism*; D013583:Synovial Membrane / Q000378:metabolism*
D008712:Methicillin; D002512:Cephalothin; D010068:Oxacillin