The effect of diuredosan on Echinococcus granulosus and Taenia hydatigena infections in dogs.
Diuredosan has been tested against Echinococcus granulosus and Taenia hydatigena infections in dogs. The drug showed significant activity against T hydatigena, but there was no significant dose response curve against E granulosus in this trial. Two treatments at 50 mg/kg or 100 mg/kg, however, reduced the number of dogs infected with hydatid worms. Worms were still present in some dogs after three treatments at 50 mg/kg. Vomiting and diarrhoea were relatively common sequelae at and above 50 mg/kg.
D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004443:Echinococcosis / Q000188:drug therapy / Q000662:veterinary*; D005260:Female; D008297:Male; D009943:Organophosphorus Compounds / Q000627:therapeutic use*; D010671:Phenylurea Compounds / Q000627:therapeutic use; D013622:Taeniasis / Q000188:drug therapy / Q000662:veterinary*
D000871:Anthelmintics; D009943:Organophosphorus Compounds; D010671:Phenylurea Compounds; C012545:uredofos