Correlation of infrared spectroscopy with platelet morphology in blood compatibility studies of polydimethylsiloxane membranes.
Oxygenator membranes, polydimethylsiloxane elastomer, exposed to flowing heparinized canine blood in a perfusion system have been studied with respect to the platelet activation and the morphology of the membranes. Utilizing Fourier transform infrared spectroscopy couple with attenuated total reflection technique (ATR) and laser Raman spectroscopy, no obvious differences in morphology and composition of the membranes have been detected while electron microscopic study shows difference in platelet aggregation.
D000818:Animals; D001672:Biocompatible Materials; D001769:Blood / Q000187:drug effects; D001792:Blood Platelets / Q000648:ultrastructure*; D004129:Dimethylpolysiloxanes / Q000633:toxicity; D004285:Dogs; D010107:Oxygenators, Membrane; D010974:Platelet Aggregation / Q000187:drug effects; D012828:Silicones / Q000633:toxicity; D013055:Spectrophotometry, Infrared
D001672:Biocompatible Materials; D004129:Dimethylpolysiloxanes; D012828:Silicones