Three-dimensional mapping of the sweet taste receptor site.
The active sites of the receptors for sweet and bitter tastants are shown to be related by a simple symmetry operation. This relationship, in turn, allows the identification of the critical geometrical features of both receptor sites. The model proposed for the sweet site is shown to be consistent with a large number of (conformationally rigid) sweet molecules.
D008958:Models, Molecular; D011487:Protein Conformation; D013329:Structure-Activity Relationship; D013650:Taste Buds / Q000032:analysis*