Enhancement of p-aminohippurate accumulation in renal cortical slices after repeated administrations of various organic anionic drugs to rats of different ages.
After repeated administrations of various organic anionic drugs to rats of different ages, an enhancement of paminohippurate accumulation was observed in renal cortical slices from adult but not from newborn and infant rats. The effect can be interpreted as specific substrate-induced stimulation of the organic anion transport.
D000375:Aging; D000618:Aminohippuric Acids / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn; D003513:Cycloheximide / Q000494:pharmacology; D003518:Cyclopenthiazide / Q000494:pharmacology; D005260:Female; D007672:Kidney Cortex / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010637:Phenolsulfonphthalein / Q000494:pharmacology; D011339:Probenecid / Q000494:pharmacology; D051381:Rats; D013268:Stimulation, Chemical; D013421:Sulfamethoxypyridazine / Q000494:pharmacology; D014325:Tromethamine / Q000494:pharmacology; D010130:p-Aminohippuric Acid / Q000378:metabolism* / Q000494:pharmacology
D000618:Aminohippuric Acids; D014325:Tromethamine; D003513:Cycloheximide; D010637:Phenolsulfonphthalein; D011339:Probenecid; D013421:Sulfamethoxypyridazine; D003518:Cyclopenthiazide; D010130:p-Aminohippuric Acid