Inhibition of Tritrichomonas foetus by vermiculine in vitro.
The macrolide aglycosidic antibiotic vermiculine, added to the cultivation medium to a concentration of 30 micogram/ml, has an in vitro inhibitory effect on Tritrichomonas foetus. The agent interacts rapidly with the cells, causing irreversible changes after several hours of action. The changes are not repaired on removing the agent; the cells suffer from a rapid inhibition of nucleic acid synthesis, the protein synthesis remaining intact.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis; D007783:Lactones / Q000096:biosynthesis / Q000494:pharmacology; D010407:Penicillium / Q000378:metabolism; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis; D014318:Tritrichomonas / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism
D000900:Anti-Bacterial Agents; D007783:Lactones; D012313:RNA; D004247:DNA