Sex hormone levels and gonadotrophin release in premature ovarian failure.
Premature ovarian failure was studied in ten women under the age of 30; eight had an ovarian biopsy and five of these showed primordial follicles. Plasma levels of oestradiol and progesterone were similar to the follicular phase of a normal menstrual cycle, but in eight patients cervical smears showed a cornification index of less than one per cent. Levels of both androgens and of sex hormone binding globulin capacity were generally normal. Administration of LH-RH caused a release of FSH which was similar to post menopausal women and higher than both. Two patients were treated with exogenous gonadotrophins without effect.
D000293:Adolescent; D000328:Adult; D000568:Amenorrhea / Q000503:physiopathology; D002584:Cervix Uteri / Q000473:pathology; D004958:Estradiol / Q000097:blood*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D006062:Gonadotropins / Q000378:metabolism*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D007986:Luteinizing Hormone / Q000378:metabolism; D008594:Menopause, Premature; D010049:Ovarian Diseases / Q000097:blood / Q000503:physiopathology*; D011374:Progesterone / Q000097:blood*
D006062:Gonadotropins; D011374:Progesterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone