title: Fetal- and uterine-specific antigens in human amniotic fluid.
abstract: Removal of the major maternal serum proteins from second trimester amniotic fluid by antibody affinity chromatography revealed various soluble tissue antigens, of which two were fetal-specific skin proteins and another, of alpha2-mobility, was specific to the uterus, and was therefore designated alpha-uterine protein (AUP). These proteins could not be detected in maternal serum by antibody-antigen crossed electrophoresis. The concentration of AUP in amniotic fluid reached a maximum between 10 and 20 weeks of gestation, suggesting that there is an influx of uterine protein into the amniotic fluid at this stage of pregnancy.
mesh_terms: D000653:Amniotic Fluid / Q000276:immunology*; D000915:Antibody Affinity; D000918:Antibody Specificity; D000941:Antigens / Q000032:analysis*; D002846:Chromatography, Affinity; D005260:Female; D005333:Fetus / Q000276:immunology; D006801:Humans; D007123:Immunoelectrophoresis, Two-Dimensional; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D014599:Uterus / Q000276:immunology
chemical_list: D000941:Antigens