Preparation of some prostaglandin E1 and omega-homo-prostaglandin E1 esters and their inhibiting properties on rat blood platelet aggregation.
Various esters of omega-homo-prostaglandin E1 and prostaglandin E1 were prepared in a yield of 28-55% to investigate their effect on ADP-induced aggregation of rat blood platelets. The biopotency of the omega-homo-PGE1-esters is about four times higher than that of the corresponding PGE1-esters. Furthermore, the biopotency of aliphatic esters decreases with increasing chain length of the ester group.
D000818:Animals; D066298:In Vitro Techniques; D008722:Methods; D010974:Platelet Aggregation / Q000187:drug effects*; D011459:Prostaglandins E, Synthetic / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats
D011459:Prostaglandins E, Synthetic