Some effects of a thallium salt on the proliferation of hair follicle cells.
Thallium sulphate has been given to young rats at 4 and 7 days of age and the mitotic activity of the hair follicles has been assessed quantitatively. It has been found that there is a marked decline in mitotic rate over 48 hr in the thallium-treated animals, which is followed by variable amounts of cell death in the matrix zone. No specific mitotic lesion was found or change in cell cycle indices. A failure of energy metabolism is suggested as a possible cause of the inhibition of hair follicle mitosis by thallium.
D000818:Animals; D000831:Animals, Newborn; D002453:Cell Cycle / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003864:Depression, Chemical; D006197:Hair / Q000166:cytology / Q000187:drug effects*; D008938:Mitosis / Q000187:drug effects*; D051381:Rats; D013793:Thallium / Q000633:toxicity*; D013997:Time Factors
D013793:Thallium