[Tubular secretion of phosphate in the human kidney (author's transl)].
There are a few scattered publications on primary tubulopathies, where a net secretion of phosphorus by renal tubules, a mechanism usually not existing in man, is shown. By means of a further case, we are able to demonstrate a 30% increase of phosphate excretion over filtration after a phosphate load. The mechanism of action will be discussed. Under certain conditions like a rapid increase in serum phosphorus or after volume expansion a tubular secretory mechanism of phosphate can be unmasked. As this secretory mechanism goes into action only beyond a certain serum threshold of phosphorus and a transport maximum cannot be shown it is most likely that passive transport by means of an increased diffusion cell to lumen is the proposed mechanism involved.
D000293:Adolescent; D001692:Biological Transport; D006030:Glycosuria, Renal / Q000378:metabolism*; D006801:Humans; D007684:Kidney Tubules / Q000378:metabolism*; D008297:Male; D010710:Phosphates / Q000378:metabolism*
D010710:Phosphates
Die Phosphatsekretion der menschlichen Niere.