Remissions induced in hereditary angioneurotic edema with an attenuated androgen (danazol): correlation between concentrations of C1-inhibitor and the forth and second components of complement.
Serum concentrations of antigenic and functional C1-INH increased in patients in whom remissions from attacks of HANE were induced with danazol. The levels of C4 were directly related to serum concentrations of C1-INH antigens up to a concentration of about half the C1-INH found in normal plasma; at this point, the C4 concentrations were in the normal range and no longer correlated well with C1-INH concentration. Serum C2 levels correlated less well with C1-INH concentration. In normal serum there was a poor correlation between C1-INH, C4, and C2 levels, suggesting that C1-INH is normally present in excess of the amount needed for normal C4 levels. The increments in serum C1-INH were related to the dose of danazol.
D000799:Angioedema / Q000097:blood / Q000188:drug therapy* / Q000235:genetics; D003174:Complement C1 Inactivator Proteins / Q000378:metabolism*; D003175:Complement C2 / Q000378:metabolism*; D003181:Complement C4 / Q000378:metabolism*; D003613:Danazol / Q000627:therapeutic use*; D006801:Humans; D011245:Pregnadienes / Q000627:therapeutic use*; D012075:Remission, Spontaneous
D003174:Complement C1 Inactivator Proteins; D003175:Complement C2; D003181:Complement C4; D011245:Pregnadienes; D003613:Danazol