title: [Changes in the functional state and ultrastructure of the cells of the zona glomerulosa of the rat adrenal cortex under prolonged immobilization stress].
abstract: Experiments were conducted on male rats aged from 45 to 50 days; during the development of the general adaptation syndrome distinct functional and ultrastructural shifts originated in the adrenal cortex glomerular zone at the early and end stages of the reaction pointing to the intensification of biosynthesis and of aldosterone secretion. At the early periods (immobilization for 30 min) increased adrenocorticosteroid activity was conditioned by factors influencing the early stages of steroidogenesis, chiefly by corticotropine. Aldosterone biosynthesis and secretion stimulation after 72 hours of immobilization was connected with the activation of the renin-angiotensin system, and, possibly, with factors influencing the end stages of steroidogenesis.
mesh_terms: D000302:Adrenal Cortex / Q000503:physiopathology* / Q000648:ultrastructure; D000450:Aldosterone / Q000096:biosynthesis / Q000097:blood; D000818:Animals; D007103:Immobilization; D008297:Male; D051381:Rats; D013312:Stress, Physiological / Q000503:physiopathology*; D013997:Time Factors
chemical_list: D000450:Aldosterone
vernacular_title: Izmeneniia funktsional'nogo sostoianiia i ul'trastruktury kletok klubochkovoĭ zony kory nadpochechnikov krys v usloviiakh dlitel'nogo immobilizatsionnogo stressa.