title: Inhibitory effect of virazole (ribavirin) on the replication of tomato white necrosis virus (VNBT).
abstract: Tomato plants (Lycopersicon esculentum Mill.) inoculated with tomato white necrosis virus (VNBT) and treated with Virazole (1-beta-D-ribofuranosyl--1, 2, 4-triazole-3-carboxamide) at a concentration of 500 mg/l developed systemic virus symptoms in only 40 per cent of the plants in which a remarkable reduction in virus concentration was also observed. From inoculated and Virazole-treated plants which had produced no symptoms, no virus could be recovered. This result suggests that Virazole may inhibit replication of VNBT in tomato.
mesh_terms: D010942:Plant Viruses / Q000187:drug effects* / Q000254:growth & development; D010944:Plants / Q000382:microbiology*; D012254:Ribavirin / Q000494:pharmacology*; D012263:Ribonucleosides / Q000494:pharmacology*
chemical_list: D012263:Ribonucleosides; D012254:Ribavirin