[Effect of triquinol on the central nervous system].
The authors examined the influence of the preparation triquinol on the function of the central nervous system, using neuropharmacological and electrophysiological methods. Traquinol in small doses revealed slight stimulating central effect, causing uneasiness, increased reaction to touch and pain, slight exophthalmia, These manifestations were accepted as a sign of the sympathycomimetic action of the preparation. The large doses caused myorelaxing phenomena-reduced spontaneous motor activity, muscular tonus, inhibition of the polysynaptic reflexes. Electroencephalographic examinations showed lowering of the threshold for obtaining the reaction of waking during acute experiments and of the threshold for obtaining desynchronization after exteroceptive stimuli. These data could be explained by the sympathycomimetic effect of the preparation.
D000818:Animals; D001993:Bronchodilator Agents; D002490:Central Nervous System / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004336:Drug Antagonism; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D004569:Electroencephalography; D007546:Isoquinolines / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D051381:Rats; D012018:Reflex / Q000187:drug effects; D013997:Time Factors; D014213:Tretoquinol / Q000494:pharmacology*
D001993:Bronchodilator Agents; D007546:Isoquinolines; D014213:Tretoquinol
Vliianie na trikvinol vurkhu tsentralnata nerna sistema.