title: Comparative studies on the effect of hemoperfusion and hemodialysis on the elimination of some uremic toxins.
abstract: This study, performed on patients with terminal renal failure, compares the changes in plasma concentrations of middle molecules, myoinositol, low molecular weight metabolites, and blood components during 4 hour periods of hemodialysis and hemoperfusion over a charcoal cartridge. After hemoperfusion there is a more marked decrease of adsorbable substances such as middle molecules, creatinine, and uric acid, whereas after hemodialysis there is a greater change in serum concentrations of myoinositol, urea, and electrolytes. The findings show that although hemoperfusion over a charcoal cartridge cannot replace hemodialysis in the treatment of chronic renal failure, it is effective as a complementary method, because of the better removal of some uremic toxins.
mesh_terms: D001792:Blood Platelets / Q000473:pathology; D002118:Calcium / Q000097:blood; D002452:Cell Count; D003404:Creatinine / Q000097:blood; D005340:Fibrinogen / Q000032:analysis; D006464:Hemoperfusion; D006801:Humans; D007294:Inositol / Q000097:blood; D007676:Kidney Failure, Chronic / Q000628:therapy*; D008274:Magnesium / Q000097:blood; D011188:Potassium / Q000097:blood; D006435:Renal Dialysis; D014508:Urea / Q000097:blood
chemical_list: D007294:Inositol; D014508:Urea; D005340:Fibrinogen; D003404:Creatinine; D008274:Magnesium; D011188:Potassium; D002118:Calcium