title: Response of cattle to inoculation with atypical mycobacteria of bovine origin.
abstract: Ten strains of atypical mycobacteria originally isolated from cattle were inoculated into cattle. Each strain was injected subcutaneously into one animal and into a mesenteric lymph node of another. Four weeks and 10 weeks after inoculation the cattle were tuberculin tested with bovine PPD, avian PPD and appropriate homologous PPD. Three strains produced a significant level of sensitivity to bovine PPD at the 4-week test but by the 10-week test no animal gave a significant response. The sensitivity to all tuberculins was less at the 10-week test than at the 4-week test. At both tests the response to avian PPD was equal to or exceeded that to bovine PPD. Of 4 strains originally from cattle sensitive to mammalian tuberculin only 2 produced sensitivity of bovine PPD in this experiment. Cultural isolation of mycobacteria from necropsy material was correlated neither with sensitivity to bovine PPD nor with the presence of lesions.
mesh_terms: D000818:Animals; D002417:Cattle; D009165:Mycobacterium Infections, Nontuberculous / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary; D012867:Skin / Q000473:pathology; D013997:Time Factors; D014374:Tuberculin Test; D014380:Tuberculosis, Bovine / Q000175:diagnosis* / Q000473:pathology