Antiallergic activity of some 9H-xanthen-9-one-2-carboxylic acids.
The synthesis and antiallergic activity of a new series of 9H-xanthen-9-one-2-carboxylic acids are described. Antiallergic activity was evaluated in the rat passive cutaneous anaphylaxis (PCA) screen. Biological results were analyzed using regression analysis techniques, and the antiallergic activity of the compounds in the series was found to be highly correlated with substituent size.
D000818:Animals; D008297:Male; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects*; D051381:Rats; D013329:Structure-Activity Relationship; D014966:Xanthenes / Q000138:chemical synthesis* / Q000494:pharmacology
D014966:Xanthenes