The influence of pharmacological agents on the accumulation of egzogenic noradrenalin in nervous tissue cultivated in vitro. I. Effect of desipramine.
The authors investigated absorption of noradrenalin by neurons and glia cells cultivated in vitro. Material was taken from locus coreuleus of 3, 6, 12, 18, 24, and 36 days old rats. On the basis of observations, the authors found out that absorption of egzogenic noradrenalin changes with the growth of animals. In animals less than 24 days old, noradrenalin is absorbed not only by neurons but also by glia cells. Desipramin affects the egzogenic noradrenalin absorption clearly over the 12th day of life.
D000042:Absorption; D000367:Age Factors; D000818:Animals; D046508:Culture Techniques; D003891:Desipramine / Q000494:pharmacology*; D005260:Female; D008125:Locus Coeruleus; D008297:Male; D009457:Neuroglia / Q000187:drug effects / Q000378:metabolism*; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats
D003891:Desipramine; D009638:Norepinephrine