title: Cancer of gallbladder with severe thrombocytosis.
abstract: An autopsy case of severe thrombocytosis associated with cancer of gallbladder is described as the first case in the literature. A 78-year-old male patient was admitted to the hospital with abnormal hepatic functions on August 6, 1975. Laboratory examination revealed platelet count of 5,664,000/cu mm, anemia, leukocytosis and bilirubinemia. Jaundice was progressive and the patient died after a month. Severe thrombocytosis persisted throughout the course. Main autopsy findings were cancer of gallbladder with metastasis to the liver, fibrosis of spleen and purulent bronchopneumonia. A possible mechanism of unusually severe degree of thrombocytosis associated with the present case is discussed in light of the literature.
mesh_terms: D000230:Adenocarcinoma / Q000150:complications* / Q000209:etiology / Q000473:pathology; D000368:Aged; D005706:Gallbladder Neoplasms / Q000150:complications* / Q000209:etiology / Q000473:pathology; D006801:Humans; D008297:Male; D013158:Splenic Diseases / Q000503:physiopathology; D013922:Thrombocytosis / Q000150:complications* / Q000473:pathology