The influence of protein binding on the pharmacokinetics of sulphadimethoxine in rabbits.
The pharmacokinetics of sulphadimethoxine was investigated in rabbits at five dose levels. A significant nonlinearity of dose dependent pharmacokinetics was demonstrated. A large dose dependent change in per cent of sulphadimethoxine bound to plasma proteins was shown. It is concluded that the nonlinearity of the pharmacokinetics of sulphadimethoxine is mainly caused by the dose dependent changes in per cent of drug bound to plasma proteins.
D000107:Acetylation; D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D007700:Kinetics; D008297:Male; D008954:Models, Biological; D011485:Protein Binding; D011817:Rabbits; D013412:Sulfadimethoxine / Q000097:blood*
D001798:Blood Proteins; D013412:Sulfadimethoxine