Changes in bone mineral content in women with natural menopause during treatment with female sex hormones.
The bone mineral content was determined in eleven women with a natural menopause by X-ray spectrophotometry during treatment with a combinations of estrogens and a gestagen. During a three-year follow-up period the hormone treated women significantly increased (P less than 0.05) their mineral content by 3% a year on average, as compared with a control group. Even in patients who had passed the menopause several years previously, the increase occurred and was particularly great during the first year of treatment.
D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism*; D002979:Climacteric; D004359:Drug Therapy, Combination; D004958:Estradiol / Q000627:therapeutic use*; D004964:Estriol / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008593:Menopause; D008875:Middle Aged; D008903:Minerals / Q000378:metabolism*; D009640:Norethindrone / Q000627:therapeutic use*
D008903:Minerals; D004958:Estradiol; D004964:Estriol; D009640:Norethindrone