[Effect of nonachlazine and oxyphedrin on a focus of myocardial ischemia].
In experimental angina pectoris of dogs developed by Sze-keres et al, 1976, and modified by the authors it was shown that nonachlazine in doses of 3 and 5 mg/kg decreased or even completely prevented the ST segment elevation on the epicardial electrogram from the focus of myocardial ischemia. Oxyphedrine in doses of 0.05, 0.1, and 0,3 mg/kg had no such effect. In doses of 0.1 and 0.3 mg/kg the drug aggravated the epicardial electrogram.
D000818:Animals; D003326:Coronary Circulation; D003327:Coronary Disease / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D004285:Dogs; D004562:Electrocardiography; D009628:Nonachlazine / Q000008:administration & dosage / Q000627:therapeutic use*; D010099:Oxyfedrine / Q000008:administration & dosage / Q000627:therapeutic use*; D010640:Phenothiazines / Q000627:therapeutic use*; D011427:Propiophenones / Q000627:therapeutic use*
D010640:Phenothiazines; D011427:Propiophenones; D009628:Nonachlazine; D010099:Oxyfedrine
Vliianie nonakhlazina i oksifedrina na ochag ishemii miokarda.