Expression of HLA-A, but not of HLA-B, in mouse-human somatic cell hybrids carrying the region p21 leads to pter of human chromosome 6.
Mouse-human somatic cell hybrids containing human chromosome 17 carrying the region p21 leads to pter of human chromosome 6 and no other human chromosomes, were found to express HLA-A but not HLA-B. Counterselection of the hybrid cells in medium containing 5-bromodeoxyuridine resulted in the growth of hybrid cells that have concordantly lost the expression of HLA-A and the human translocation chromosome.
D000818:Animals; D002874:Chromosome Mapping; D002902:Chromosomes, Human, 16-18; D002906:Chromosomes, Human, 6-12 and X; D002999:Clone Cells; D005796:Genes; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D006822:Hybrid Cells; D007621:Karyotyping; D008297:Male; D051379:Mice; D014178:Translocation, Genetic
D006680:HLA Antigens