[The anomalies of limbs obtained by injections of cyclophosphamid to the pregnant rabbit (author's transl)].
By injections of cyclophosphamid to pregnant rabbits, we obtained different sorts of agenesis. These anomalies are the consequence of a lack of the quantity of mesenchyme necessary to the formation of the limbs. The final malformation depends on the date, the dose and the period of action of the cyclophosphamid.
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000818:Animals; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D017880:Limb Deformities, Congenital; D009024:Morphogenesis / Q000187:drug effects; D011247:Pregnancy; D011817:Rabbits
D003520:Cyclophosphamide
Les anomalies des membres obtenues par le cyclophosphamide chez l'embryon de lapin.