Thrombocytopenia in the absence of leukopenia associated with the use of neuroleptics.
Thrombocytopenia, a fairly uncommon side effect of phenothiazine treatment, usually appears in the presence of a concommitant leukopenia. The authors report 1 patient in whom the illness appeared in the presence of a long known Beta thalassemia but without evidence of alteration in myeloid or lymphoid series. Platelet changes were seen in the presence of a butyrophenone and an aliphatic phenothiazine. A piperazine derivative was used without difficulty.
D000328:Adult; D001590:Benztropine / Q000009:adverse effects*; D002746:Chlorpromazine / Q000009:adverse effects*; D006220:Haloperidol / Q000009:adverse effects*; D006801:Humans; D008297:Male; D010546:Perphenazine / Q000627:therapeutic use; D012559:Schizophrenia / Q000188:drug therapy; D013789:Thalassemia / Q000150:complications; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000150:complications; D014268:Trifluoperazine / Q000627:therapeutic use; D014282:Trihexyphenidyl / Q000627:therapeutic use; D014326:Tropanes / Q000009:adverse effects*
D014326:Tropanes; D001590:Benztropine; D014268:Trifluoperazine; D014282:Trihexyphenidyl; D010546:Perphenazine; D006220:Haloperidol; D002746:Chlorpromazine