Hemoperfusion in the management of digoxin toxicity.
Resin hemoperfusion was used in a long-term dialysis patient who inadvertently ingested a quadruple dose of digoxin for five days. Severe gastrointestinal symptoms improved, and impressive plasma digoxin clearances were observed. Cellulose-coated activated charcoal was used in another patient who had ingested a massive dose of digoxin. Gastrointestinal and CNS symptoms improved, and second-degree heart block with life-threatening bradycardia cleared during hemoperfusion. Digoxin toxicity may be added to the list of conditions that can be treated by this method.
D002606:Charcoal; D004077:Digoxin / Q000008:administration & dosage / Q000506:poisoning*; D005260:Female; D006327:Heart Block / Q000628:therapy; D006464:Hemoperfusion / Q000379:methods*; D006801:Humans; D008658:Inactivation, Metabolic; D007700:Kinetics; D008508:Medication Errors; D008875:Middle Aged; D012116:Resins, Plant
D012116:Resins, Plant; D002606:Charcoal; D004077:Digoxin