title: Effects of enflurane on haemodynamics and oxygen uptake with special reference to the influence of surgical stress.
abstract: The influence on central haemodynamics of enflurane, in uniform anaesthetic concentration (1.5 MAC), was studied in 10 normocapnic patients undergoing upper abdominal surgery. The patients were studied awake, during anaesthesia prior to surgery, and during surgery. On institution of anaesthesia, cardiac output (QT) fell from 5.05 +/- 0.51 to 4.12 +/- 0.15 1/min and systemic vascular resistance (SVR) decreased from 2.36 +/- 0.22 to 1.93 +/- 0.18 kPa min. 1(-3). The arteriovenous oxygen content difference (AVD) did not change. On commencement of surgery, AVD diminished from 38.5 +/- 2.6 to 30.8 +/- 1.9 ml/min and QT rose to 5.82 +/- 0.46 1/min, while SVR remained unchanged. It is concluded that the fall in QT seen during enflurane anaesthesia is caused by a diminished tissue oxygen demand. It is also suggested that enflurane acts as an alpha-blocking agent.
mesh_terms: D000005:Abdomen / Q000601:surgery*; D000328:Adult; D000768:Anesthesia, General; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D004737:Enflurane / Q000494:pharmacology*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D008738:Methyl Ethers / Q000494:pharmacology*; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption / Q000187:drug effects*; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D008738:Methyl Ethers; D004737:Enflurane; D010100:Oxygen