title: Rheumatoid factor interference with the latex agglutination test for fibrin degradation products.
abstract: The latex agglutination test for FDP is widely employed clinically to aid in the diagnosis of DIC and other conditions. Of sera containing RF, 93% demonstrated positive FDP latex agglutination tests. Reducing agents in all instances destroyed the RF agglutinating capability. Futhermore, 86% of sera positive for FDP and RF became FDP-negative following reduction. Therefore RF was responsible for false-positive FDP latex agglutination tests in the majority of patients. Reduction of patient sera is a rapid, simple method to distinguish a positive FDP test from a false-positive due to RF.
mesh_terms: D001168:Arthritis / Q000175:diagnosis; D001172:Arthritis, Rheumatoid / Q000175:diagnosis; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D006801:Humans; D007841:Latex Fixation Tests; D012217:Rheumatoid Factor
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; D012217:Rheumatoid Factor