Memory impairment in Korsakoff's psychosis: a correlation with brain noradrenergic activity.
The concentration of the primary brain metabolite of norepinephrine is diminished in the lumbar spinal fluid of patients with Korsakoff's syndrome. The extent of its reduction is significantly correlated with measures of memory impairment for individual patients. These data suggest that the memory disorder of Korsakoff's syndrome may result from damage to ascending noradrenergic pathways by the diencephalic and brainstem lesions associated with this disease.
D000425:Alcohol Amnestic Disorder / Q000134:cerebrospinal fluid* / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D006018:Glycols / Q000134:cerebrospinal fluid*; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D008569:Memory Disorders / Q000134:cerebrospinal fluid*; D008734:Methoxyhydroxyphenylglycol / Q000134:cerebrospinal fluid*; D009638:Norepinephrine / Q000378:metabolism; D014642:Vanilmandelic Acid / Q000134:cerebrospinal fluid
D006018:Glycols; D008734:Methoxyhydroxyphenylglycol; D006897:Hydroxyindoleacetic Acid; D014642:Vanilmandelic Acid; D009638:Norepinephrine; D006719:Homovanillic Acid