Myelofibrosis presenting as hypermetabolic bone disease by radionuclide imaging in a patient with asplenia.
In a patient with myelocytic anemia, hepatomegaly, and metastases suggested by radiographic evidence of sclerosis throughout the pelvis and spine, a liver-spleen scan revealed mild hepatomegaly and an absent splenic image. A bone scan demonstrated diffusely increased activity in all bones, especially in the joint regions. A bone marrow scan showed only hepatic activity but no significant uptake in the bone marrow. Ultrasonography and contrast angiography failed to identify a spleen. The findings from a bone marrow biopsy and a peripheral blood examination indicated myelofibrosis. The implications of an increased concentration of radiopharmaceuticals in bone are briefly discussed.
D000368:Aged; D000740:Anemia / Q000150:complications; D001847:Bone Diseases / Q000000981:diagnostic imaging* / Q000209:etiology; D006801:Humans; D008297:Male; D055728:Primary Myelofibrosis / Q000150:complications / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D013154:Spleen / Q000002:abnormalities*