Effects of autoprothrombin II-A on epinephrine-induced platelet aggregation of normal- and coumadin-treated dogs.
Platelet-rich plasma from dogs and from coumadin-treated dogs aggregated at the same optimum concentration of epinephrine. Neither protein C nor its active form called autoprothrombin II-A was necessary for aggregation of dog platelets with epinephrine. For platelet aggregation, suboptimal concentrations of epinephrine were potentiated by addition of purified autoprothrombin II-A. The latter, by itself, induced platelet aggregation in high concentration.
D000818:Animals; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000494:pharmacology*; D005164:Factor IX / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D013997:Time Factors; D014859:Warfarin / Q000494:pharmacology*
D014859:Warfarin; D005164:Factor IX; D004837:Epinephrine