title: Modification of the tuberculin reaction by levan.
abstract: High molecular levan (polyfructoside) inhibits the skin tuberculin reaction in guinea pigs as judged by the degree of induration and erythema. The effect is dose-dependent. No effect on cellular infiltration was observed in histological studies. The lymph nodes of levan-treated animals were smaller and exhibited a much milder granulomatous reaction than those of non-treated animals.
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D005620:Freund's Adjuvant; D005630:Fructans / Q000494:pharmacology*; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000473:pathology*; D008198:Lymph Nodes / Q000187:drug effects / Q000473:pathology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011134:Polysaccharides / Q000494:pharmacology*; D013154:Spleen / Q000187:drug effects; D014374:Tuberculin Test
chemical_list: D005630:Fructans; D011134:Polysaccharides; D005620:Freund's Adjuvant