[Plasma kinin system indices in diabetes mellitus patients before and after treatment with prodectin].
Kinin system was investigated in 82 patients suffering from diabetes mellitus of various severity. To make pathogenetically substantiated pharmacological correction of the kinin system activity prodectin--kinin antagonist--was used in these patients. A conclusion was drawn that the blood plasma kinin system was activated in the patients with moderately severe and severe diabetes. The activity of total kallikrein and kininogen became normal against the background of prodectin treatment. The blood plasma kinin system activity was normalized simultaneously with the improvement of the diabetic angiopathies course.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002219:Carbamates / Q000627:therapeutic use*; D003920:Diabetes Mellitus / Q000097:blood / Q000188:drug therapy*; D003925:Diabetic Angiopathies / Q000188:drug therapy; D006801:Humans; D007004:Hypoglycemic Agents; D007610:Kallikreins / Q000097:blood; D007704:Kininogens / Q000097:blood; D007705:Kinins / Q000097:blood*; D001121:Lysine Carboxypeptidase / Q000097:blood; D008875:Middle Aged; D011727:Pyridinolcarbamate / Q000627:therapeutic use*
D002219:Carbamates; D007004:Hypoglycemic Agents; D007704:Kininogens; D007705:Kinins; D011727:Pyridinolcarbamate; D001121:Lysine Carboxypeptidase; D007610:Kallikreins
Pokazateli kininovoĭ sistemy plazmy krovi u bol'nykh sakharnym diabetom do i posle lecheniia prodektinom.