Inhibition of the alkylation of nucleic acids and of the metabolism of 1,2-dimethylhydrazine by aminoacetonitrile.
Pretreatment of rats with aminoacetonitrile inhibited the metabolism of [14C]1,2-dimethylhydrazine to 14CO2 and increased the expiration of [14C]-azomethane. Alkylation of nucleic acids following administration of 1,2-dimethylhydrazine was reduced by aminoacetonitrile to 5% of control levels in liver, 11% of control levels in kidney and 43% of control levels in colon.
D000097:Acetonitriles / Q000494:pharmacology*; D000478:Alkylation; D000607:Aminoacetonitrile / Q000494:pharmacology*; D000818:Animals; D002245:Carbon Dioxide / Q000096:biosynthesis; D004247:DNA / Q000378:metabolism*; D004127:Dimethylhydrazines / Q000378:metabolism*; D004347:Drug Interactions; D005260:Female; D008763:Methylhydrazines / Q000378:metabolism*; D051381:Rats
D000097:Acetonitriles; D004127:Dimethylhydrazines; D008763:Methylhydrazines; D002245:Carbon Dioxide; D000607:Aminoacetonitrile; D004247:DNA