title: Effect of thiamylal on the sensitivity of glycerinated cardiac fibres to calcium.
abstract: Clarification of the mechanisms of the myocardial depression produced by thiamylal was sought by studying the effect of thiamylal upon the sensitivity of contractile proteins to calcium (Ca2+), by using glycerinated muscle fibres from the canine right ventricle. The dose--response relationship between the concentration of Ca2+ and the force of contraction of the glycerinated cardiac muscle fibres was not shifted from the control curve by the administration of thiamylal 67 microgram ml-1. This result suggests that the changes in the sensitivity of contractile proteins to Ca2+ are not responsible for the depression of myocardial performance produced by thiamylal.
mesh_terms: D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D003864:Depression, Chemical; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D009124:Muscle Proteins / Q000502:physiology*; D009200:Myocardial Contraction / Q000187:drug effects*; D013840:Thiamylal / Q000494:pharmacology*
chemical_list: D009124:Muscle Proteins; D013840:Thiamylal; D002118:Calcium