Thermodynamics of the isothermal interaction of human immunoglobulin G with guanidinium chloride.
A thermodynamic study of the isothermal interaction of human immunoglobulin G with guanidinium chloride, a strong denaturant, has been performed. Free energies of interaction were calculated using preferential binding data obtained by measuring densities at constant chemical potential and constant composition, respectively. Enthalpies of interaction were determined calorimetrically. The values of both thermodynamic parameters as well as those of entropies of interaction have been found to depend crucially on the extent of denaturant binding.
D006146:Guanidines; D006801:Humans; D007074:Immunoglobulin G; D008433:Mathematics; D013816:Thermodynamics
D006146:Guanidines; D007074:Immunoglobulin G