Enhancement of renal excretion of uric acid during long-term thiazide therapy.
The effect of thiazide (hydrochlorothiazide 100 mg per day orally in two divided doses for up to 3 years) on uric acid metabolism was examined in 21 patients with renal stones suffering from renal hypercalciuria or absorptive hypercalciuria. Serum concentration of uric acid increased during thiazide therapy in every patient. In 12 of 21 patients, there was a transient or persistent rise in urinary uric acid of more than 50 mg per day during treatment. The mean urinary uric acid produced by thiazide was positively correlated with the change in the renal clearance of uric acid. Thus, an increase in urinary uric acid was often associated with a rise in uric acid clearance. The results suggest that thiazide may either increase the production of uric acid or decrease the extrarenal disposal of uric acid, in some patients.
D000284:Administration, Oral; D000328:Adult; D002118:Calcium / Q000652:urine; D004341:Drug Evaluation; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage / Q000627:therapeutic use*; D007669:Kidney Calculi / Q000188:drug therapy* / Q000652:urine; D013997:Time Factors; D014527:Uric Acid / Q000097:blood / Q000378:metabolism* / Q000652:urine
D006852:Hydrochlorothiazide; D014527:Uric Acid; D002118:Calcium