Modification of lymphocyte response to phytomitogens by polycations and polyanions.
The stimulating effect on mitogen-induced lymphocyte response by polycationic compounds such as polylysine, DEAE dextran protamine and methylated albumin, is studied at different serum-protein concentrations and mitogen concentrations. It is suggested that the polar interaction between polycationic compounds and glycoproteins are of major importance for reactivity of lymphocytes to mitogens.
D000838:Anions / Q000494:pharmacology*; D002412:Cations / Q000494:pharmacology*; D002478:Cells, Cultured; D002570:Ceruloplasmin / Q000494:pharmacology; D002809:Chondroitin Sulfates / Q000494:pharmacology; D003911:Dextrans / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D037102:Lectins / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects*; D011107:Polylysine / Q000494:pharmacology; D011479:Protamines / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000838:Anions; D002412:Cations; D003911:Dextrans; D037102:Lectins; D011479:Protamines; D011107:Polylysine; D002809:Chondroitin Sulfates; D002570:Ceruloplasmin