Somatomedin activity in human cord plasma and relationship to birth size, insulin, growth hormone, and prolactin.
Somatomedin activity was determined by a rabbit chondrocyte bioassay in cord plasma from babies of between 37 and 41 wk gestation. A positive correlation (P less than 0.001) was found between plasma somatomedin activity and birthweight. The mean somatomedin activity in infants whose birthweights were within 1 SD of the mean (3293 g) was 0.76 +/- 0.27 U/ml. Mean somatomedin activity in infants whose weight was (a) greater than the mean weight +1 SD was 1.3 +/- 0.17 U/ml, and (b) less than the mean weight -1 SD was 0.48 +/- 0.15 U/ml. Plasma somatomedin activity was also correlated with placental weight, P less than 0.02 and gestational age, P less than 0.05. No correlation was found between plasma somatomedin activity and birth length, OFC, most measurements of skinfold thickness, cord plasma, growth hormone, prolactin or insulin.
D001724:Birth Weight; D001827:Body Height; D005260:Female; D005312:Fetal Blood / Q000032:analysis*; D005865:Gestational Age; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D007328:Insulin / Q000097:blood*; D009929:Organ Size; D010920:Placenta / Q000033:anatomy & histology; D011247:Pregnancy; D011388:Prolactin / Q000097:blood*; D012885:Skinfold Thickness; D013002:Somatomedins / Q000097:blood*
D007328:Insulin; D013002:Somatomedins; D011388:Prolactin; D013006:Growth Hormone