title: Evidence for a reciprocal relationship between lipogenesis and ketogenesis in hepatocytes from fed virgin and lactating rats.
abstract: Lipogenesis is increased in hepatocytes from fed lactating rats compared with virgin rats. Inhibition of lipogenesis with 5-(tetradecyloxy)-2-furoic acid resulted in increased ketogenesis from endogenous substrate, but not from oleate. Dihydroxyacetone increased ketogenesis from endogenous substrate, but not from oleate. Dihydroxyacetone increased lipogenesis and esterification of [1--14C]oleate and decreased ketogenesis; these changes were reversed by the inhibitor. The reciprocal relationship between lipogenesis and ketogenesis in hepatocytes from fed rats may be due to alterations in [malonyl-CoA] [McGarry, Mannaerts & Foster (1977) J. Clin. Invest. 60, 265--270; Cook, King & Veech (1978) J. Biol. Chem. 253, 2529--2531], but this mechanism is not considered to be sufficient to explain the increased ketogenesis in starvation completely.
mesh_terms: D000818:Animals; D002264:Carboxylic Acids / Q000494:pharmacology; D005260:Female; D005663:Furans / Q000494:pharmacology; D066298:In Vitro Techniques; D007657:Ketone Bodies / Q000096:biosynthesis*; D007774:Lactation; D008055:Lipids / Q000096:biosynthesis*; D008099:Liver / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D009829:Oleic Acids / Q000378:metabolism; D011247:Pregnancy; D051381:Rats
chemical_list: D002264:Carboxylic Acids; D005663:Furans; D007657:Ketone Bodies; D008055:Lipids; D009829:Oleic Acids