[Immunoreactive parathyroid hormone in samples from thyroid veins (author's transl)].
Blood samples were obtained from 16 patients with primary or secondary hyperparathyroidism by selectively catheterising cervical and thyroid veins. Immunoreactive parathyroid hormone was measured with two aminoterminal (anti-N)- and three carboxyl-terminal (anti-C)-specific antisera. Two anti-C sera and one anti-N serum were useful in localising the parathyroid tumors. In addition, the parathyroid hormone fragments were separated by gelfiltration and the immunoreactivity in the effluent was estimated with anti-N and anti-C sera. The results suggest that the usefulness of antisera for parathyroid tissue localisation is determined by their affinity for the intact hormone, regardless of their anti-N or anti-C qualities.
D002850:Chromatography, Gel; D006801:Humans; D006961:Hyperparathyroidism / Q000097:blood*; D006962:Hyperparathyroidism, Secondary / Q000097:blood*; D007106:Immune Sera; D009333:Neck / Q000098:blood supply; D010281:Parathyroid Hormone / Q000097:blood* / Q000276:immunology; D010446:Peptide Fragments; D013961:Thyroid Gland / Q000098:blood supply; D014680:Veins
D007106:Immune Sera; D010281:Parathyroid Hormone; D010446:Peptide Fragments
Immunreaktives Parathormon in Schilddrüsenvenenblut.