title: Antibody-dependent cellular cytotoxicity and natural cytotoxicity: effect of pre-treatment of human lymphocytes with deionised water and ammonium chloride.
abstract: Deionised water is an efficient red blood cell lytic agent with no demonstrable deleterious effects on ADCC and natural cytotoxicity (blood and tonsil). Treatment with isotonic ammonium chloride, however, produces a significant reduction of both ADCC and natural cytotoxicity. This reduction is less pronounced if the treatment is carried out at 4 degrees C and is temporary, recovery occurring over a 24 h period of incubation at 37 degrees C.
mesh_terms: D000643:Ammonium Chloride / Q000494:pharmacology*; D000920:Antibody-Dependent Cell Cytotoxicity; D001769:Blood; D003602:Cytotoxicity, Immunologic; D008212:Lymphocyte Depletion; D008214:Lymphocytes / Q000187:drug effects*; D014066:Palatine Tonsil; D014867:Water / Q000494:pharmacology*
chemical_list: D000643:Ammonium Chloride; D014867:Water