Hemodialysis clearance of cimetidine.
Hemodialysis clearance of cimetidine was determined in three patients and was found to range between 41.34 to 75.91 ml/min. Notwithstanding its substantial dialyzability, the amount of cimetidine removed by four hours of hemodialysis constituted only 8% to 14% of the administered dose. Accordingly, major dose adjustment on the days of dialysis treatment, as suggested in the available literature, may not be necessary.
D000328:Adult; D002927:Cimetidine / Q000008:administration & dosage / Q000097:blood*; D005260:Female; D006146:Guanidines / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis
D006146:Guanidines; D002927:Cimetidine