[Effect of neocompensan (haemodesum) on the course of experimental myocardial infarct with arrhythmias in rabbits].
In rabbits with experimental myocardial infarction (EMI) complicated by arrhthmias the antiarrhythmic action of neocompensan (haemodesum) was ascertained for the first time. In the acute period of EMI no electrolytes shifts in the blood serum of the animals were disclosed and this justified the antiarrhythmis effect of neocompensan, occurring during the first 24 hours of the experiment, to be attributed to the influence of polyvinylpyrrolidine. Besides, the drug produced in rabbits with EMI deceleration of the total blood coagulation. Following administration of neocompensan (haemodesum) no arrhythmias were recorded. Thus, neocompensan (haemodesum) displays antiarrhytmic action, has a beneficial effect on the blood coagulation system and as a result reduces the lethality among rabbits with EMI, complicated by arrhythmias.
D000818:Animals; D000889:Anti-Arrhythmia Agents; D001145:Arrhythmias, Cardiac / Q000188:drug therapy* / Q000503:physiopathology; D001777:Blood Coagulation / Q000187:drug effects; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology; D011205:Povidone / Q000627:therapeutic use*; D011817:Rabbits; D012492:Salts; D013997:Time Factors
D000889:Anti-Arrhythmia Agents; D004338:Drug Combinations; D012492:Salts; C007918:hemodes; D011205:Povidone
Vliianie neokompensana (gemodeza) na techenie éksperimental'nogo infarkta miokarda s aritmiiami u krolikov.