Rapid GLC determination of chlordiazepoxide and metabolite in serum using on-column methylation.
A rapid GLC method was developed for the assay of chlordiazepoxide in serum. After chlordiazepoxide was extracted with ether, it was methylated with trimethylanilinium hydroxide in the injection port and detected by electron capture. The assay is simple and sensitive and can be automated for large-scale clinical analysis.
D002707:Chlordiazepoxide / Q000097:blood*; D002849:Chromatography, Gas; D008722:Methods; D008745:Methylation
D002707:Chlordiazepoxide