[Study on tobramycin concentration in bone marrow (author's transl)].
Tobramycin (TOB) concentration in the bone marrow of tibia was examined 1, 2, 3 and 4 hours after intramuscular injection of 60 mg: TOB concentration in the bone marrow of tibia 1 hour after injection was 2.8 +/- 0.578 microgram/ml. Ratio to serum was 87.5%. TOB concentration in the bone marrow of tibia 2 hours after injection was 1.6 +/- 0.480 microgram/ml. Ratio to serum was 94.1%. TOB concentration in the bone marrow of tibia 3 hours after injection was 1.1 +/- 0.337 microgram/ml. Ratio to serum was 84.6%. TOB concentration in the bone marrow of tibia 4 hours after injection was 0.8 +/- 0.372 microgram/ml. Ratio to serum was 80.0%. Penetration capacity of TOB into the bone marrow of tibia was excellent.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D001853:Bone Marrow / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014031:Tobramycin / Q000097:blood / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D014031:Tobramycin