Effects of quinestrol on hepatic function in the rat.
Hepatic function in female rats given 200 microgram of quinestrol every 15 days for up to 210 days was studied. Prolonged treatment with quinestrol affected liver weight, serum cholestrol levels, biliar flux, and bromosulphthalein test, but these parameters tended toward control levels after 30 days of treatment. Quinestrol failed to affect alkaline phosphatase, oxalacetic and pyruvic transaminases and the concentration of bilirubin in serum and bile. The effects of quinestrol on hepatic function are similar to the effects of other estrogen derivatives.
D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001646:Bile / Q000502:physiology; D001663:Bilirubin / Q000097:blood; D002784:Cholesterol / Q000097:blood; D005260:Female; D008099:Liver / Q000033:anatomy & histology / Q000166:cytology / Q000502:physiology*; D009651:Norpregnatrienes / Q000494:pharmacology*; D009929:Organ Size; D011800:Quinestrol / Q000494:pharmacology*; D051381:Rats; D013448:Sulfobromophthalein / Q000097:blood; D000637:Transaminases / Q000097:blood
D009651:Norpregnatrienes; D013448:Sulfobromophthalein; D002784:Cholesterol; D000637:Transaminases; D000469:Alkaline Phosphatase; D011800:Quinestrol; D001663:Bilirubin