Experimental myringoplasty.
Different materials were compared as implants in performing a myringoplasty on rats immediately after making a total perforation, (autologous fascia, homologous tympanic membrane, homologous collagen, heterologous collagen, heterologous amnion and proplast). As a reference one group of rats had no myringoplasty done after perforating their drums. The animals were examined regularly, then killed after 40 and 64 weeks. Macroscopically and microscopically proplast and homologous collagen were very inferior to homograft tympanic membrane and autologous fascia. The best results were obtained both macroscopically and histologically with heterologous collagen and heterologous amnion.
D000650:Amnion / Q000637:transplantation; D000818:Animals; D001672:Biocompatible Materials; D003094:Collagen; D004424:Ear Canal / Q000166:cytology; D005205:Fascia / Q000637:transplantation; D009225:Myringoplasty / Q000379:methods*; D019736:Prostheses and Implants; D051381:Rats; D014182:Transplantation, Autologous; D014183:Transplantation, Heterologous; D014184:Transplantation, Homologous; D014432:Tympanic Membrane / Q000637:transplantation
D001672:Biocompatible Materials; D003094:Collagen