Calcium-dependent increase in spike duration during repetitive firing of Aplysia axon in the presence of TEA.
Repetitive stimulation was studied in the axon of the giant neuron, R2, of Aplysia in the presence of TEA. In 25 or 50 mM extracellular TEA, a plateau develops on the axon spike during repetitive stimulation at frequencies greater than 3/sec. The plateau in extracellular TEA is inhibited by 30 mM CoCl2 or 1 mM CdCl2, and is enhanced by raising the Ca concentration. Intracellular TEA induces a plateau on the axon spike at frequencies less than 1/30sec. This plateau increases in duration with repetitive stimulation at higher frequencies and is inhibited by 30 mM CoCl2 or 1 mM CdCl2. The increase in spike duration during repetitive firing in the presence of TEA is indicative of an increased entry of Ca during the spike train.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001048:Aplysia / Q000187:drug effects / Q000502:physiology*; D001369:Axons / Q000187:drug effects / Q000502:physiology*; D002104:Cadmium / Q000494:pharmacology; D002118:Calcium / Q000502:physiology*; D003035:Cobalt / Q000494:pharmacology; D066298:In Vitro Techniques; D007478:Iontophoresis; D013757:Tetraethylammonium Compounds / Q000494:pharmacology*; D013997:Time Factors
D013757:Tetraethylammonium Compounds; D002104:Cadmium; D003035:Cobalt; D002118:Calcium