[Comparative study of the action of different antibiotics on the membrane dehydrogenase activity in Micrococcus lysodeikticus].
The object of this work was to study the effect of antibiotics belonging to the groups of penicillin, tetracycline and aminoglycosides on the activity of lactate dehydrogenase, alcohol dehydrogenase and malate dehydrogenase in the membranes of Micrococcus lysodeikticus. Streptomycin, benzylpenicillin, carbenicillin and phenoxymethylpenicillin decreased the activity of the above dehydrogenases. Tetracycline and oxytetracycline activated lactate dehydrogenase and alcohol dehydrogenase in the membranes, but decreased their activity in the supernatant fraction of disintegrated membranes. The enzyme activity in the membranes was particularly inhibited by neomycin.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects / Q000201:enzymology; D002952:Citric Acid Cycle / Q000187:drug effects; D004789:Enzyme Activation / Q000187:drug effects; D008837:Micrococcus / Q000187:drug effects* / Q000201:enzymology; D010088:Oxidoreductases / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D010088:Oxidoreductases
Sravnitel'noe izuchenie deĭstviia razlichnykh antibiotikov na aktivnost' degidrogenaz membran u Micrococcus lysodeikticus.