Abdominal radiation response modified by hypoxia after intra-aortal injection of starch microspheres. Experiments in the rat.
Degradable starch microsphers were injected in the aorta of rats above the level of the superior mesenteric artery 5 min before roentgen irradiation of the abdomen. The local hypoxia, induced by the spheres, was found to have an appreciable protective effect. The dose modification factor was estimated as 0.7.
D000005:Abdomen; D000818:Animals; D001012:Aorta, Abdominal; D001835:Body Weight / Q000528:radiation effects; D003967:Diarrhea / Q000209:etiology; D000860:Hypoxia / Q000209:etiology; D007269:Injections, Intra-Arterial; D007422:Intestines / Q000098:blood supply / Q000528:radiation effects*; D008297:Male; D008863:Microspheres; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011835:Radiation Protection / Q000379:methods*; D051381:Rats; D013213:Starch
D013213:Starch