[Ultrastructure of pancreatic acinar cells under the influence of pancreozymin, serotonin and histamine].
The pancreas was removed from male white mice given intraperitoneally pancreozymin (2 i. u./kg and 4 i. u./kg), serotonin (0.2 and 0.4 mg/kg) or histamine (0.1 mg/kg) within 5--10 min. Pancreozymin caused hypertrophy of the Golgi zone and the appearance of multivesicular bodies. Serotonin induced an intensive autophagia in the apical parts of acinar cells. The effect of histamine was revealed in the rapidity of the extrusion of zymogen granules and the dilatation of cisterns of granular cytoplasmatic reticulum. Possible physiological significance of the ultrastructural alterations of acinar cells is discussed.
D000818:Animals; D002766:Cholecystokinin / Q000494:pharmacology*; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D006056:Golgi Apparatus / Q000648:ultrastructure; D006632:Histamine / Q000494:pharmacology; D008297:Male; D051379:Mice; D010179:Pancreas / Q000187:drug effects* / Q000648:ultrastructure; D012701:Serotonin / Q000494:pharmacology*
D012701:Serotonin; D006632:Histamine; D002766:Cholecystokinin
Ul'trastruktura atsinarnykh kletok podzheludochnoĭ zhelezy pod vliianiem pankreozimina, serotonina i gistamina.