[Effect of prolonged fasting on cathepsin and lipolytic enzymatic activities of the rat liver].
In the liver of rats fasting for 2,5,8 and 11 days the activity of kathepsins A, B1, C, D, phospholipases A1, A2 and of the cholinesterase was determined. Reciprocal relations in the change of the kathepsins A and D activity was revealed, whereas the kathepsins B1 and C showed a substantial fall. Of the phospholipases A1 and A2 was characteristic a progressive decline of the activity up to the 8th day of fasting. At the terminal stage a brusque activation of phospholipases, largely of the A1 phospholipase was observed, the activity of the latter reaching 205 per cent of the control level. The cholinesterase activity was consecutively declining throughout the whole of the experiment. The data obtained bear evidence to an important role of the kathepsins A and D in the adaptation of the organism to conditions of the endogenous nutrition.
D000818:Animals; D002403:Cathepsins / Q000378:metabolism*; D002802:Cholinesterases / Q000378:metabolism*; D004789:Enzyme Activation; D005215:Fasting / Q000009:adverse effects*; D005508:Food Deprivation / Q000502:physiology; D008099:Liver / Q000201:enzymology*; D008247:Lysosomes / Q000201:enzymology; D008297:Male; D010740:Phospholipases / Q000378:metabolism*; D051381:Rats; D013997:Time Factors
D010740:Phospholipases; D002802:Cholinesterases; D002403:Cathepsins
Vliianie dlitel'nogo golodaniia na aktivnost' katepsinov i nekotorykh lipoliticheskikh fermentov pecheni krys.