A physiological and morphological study of the cochlea of the rat following treatment with atoxyl and neomycin.
By means of physiological and morphological techniques the inner ear pathology following exposure to the ototoxic compounds atoxyl and neomycin was analysed in the rat. Primarily a high tone deterioration occurred with a subsequent morphological degeneration pattern among the hair cells in the basal part of the cochlea. The outer hair cells were more frequently affected than the inner hair cells following the administration of both atoxyl and neomycin.
D000818:Animals; D001147:Arsanilic Acid; D001152:Arsenicals; D001309:Auditory Threshold / Q000187:drug effects*; D003051:Cochlea / Q000187:drug effects* / Q000473:pathology; D003638:Deafness / Q000139:chemically induced; D005071:Evoked Potentials / Q000187:drug effects; D006198:Hair Cells, Auditory / Q000187:drug effects / Q000473:pathology; D007759:Labyrinth Diseases / Q000139:chemically induced* / Q000473:pathology; D009355:Neomycin; D051381:Rats
D001152:Arsenicals; D009355:Neomycin; D001147:Arsanilic Acid