Lipid peroxidation in the hemolytic uremic syndrome.
Based on recent evidence of a genetic influence on prognosis (1) and the existence of red cell membrane phospholipid depletion with low or absent serum alpha-tocopherol (2) levels in three children with the Hemolytic Uremic Syndrome (H.U.S.), we wish to suggest the existence of an inborn error of antioxident capacity as the basic pathogenetic mechanism in the development of the hemolytic uremic syndrome (H.U.S.).
D000818:Animals; D004195:Disease Models, Animal; D006463:Hemolytic-Uremic Syndrome / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D050356:Lipid Metabolism; D010084:Oxidation-Reduction; D051381:Rats; D014810:Vitamin E / Q000502:physiology
D014810:Vitamin E