Anthelmintic activities of fenbendazole against Nematodirus helvetianus in cattle: effect on egg production, embryogeny, and development of larval stages.
Calves experimentally infected with Nematodirus helvetianus were treated with a single dose of fenbendazole at the rate of 5 mg/kg of body weight. Fenbendazole was found to have an efficacy of 97.4% against adult N helvetianus. Additionally, eggs recovered 12 hours after calves were given the anthelmintic had fewer and frequently abnormal blastomeres. Fewer eggs were evident at 36 hours after treatment, and none was found at 72 hours or later. On the culturing of eggs from manure passed at 12 hours and later, almost no larval stages developed.
D000818:Animals; D001562:Benzimidazoles / Q000627:therapeutic use*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy* / Q000469:parasitology; D005243:Feces / Q000469:parasitology; D005273:Fenbendazole / Q000494:pharmacology / Q000627:therapeutic use*; D010270:Parasite Egg Count; D014251:Trichostrongyloidea / Q000187:drug effects* / Q000254:growth & development; D014252:Trichostrongyloidiasis / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*
D001562:Benzimidazoles; D005273:Fenbendazole