A spontaneous ankle deformity in an inbred strain of mouse.
A spontaneous subluxation and subsequent dislocation of the bones of the ankle has been described in the males of an inbred strain of mouse (STR/ORT). It consisted of a gradual elevation of the calcaneum which eventually came to lie along the distal end of the tibia after 6--8 mth. The astragalus rotated forward. Articulations with the navicular and tarsal bones were severely disrupted with the accompanying development of peri-articular calcifications and ossifications. With one exception the arthropathy only occurred in male mice. Of the male members of the colony over the age of 3 mth, 26.7 per cent. had at least one ankle affected. Possible aetiological factors are discussed.
D000818:Animals; D002111:Calcaneus / Q000473:pathology; D005260:Female; D006614:Hindlimb / Q000000981:diagnostic imaging / Q000473:pathology; D004204:Joint Dislocations / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011859:Radiography; D012376:Rodent Diseases / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology*; D012737:Sex Factors