Effect of human leukocyte interferon on the permeability of the cytoplasma membrane of cultured cells.
The effect of human leukocyte interferon on the cytoplasma membrane of cultured homologous cells has been investigated. U-amnion cells were labelled with (1-14C) alpha-aminoisobutyric acid (AIB), a low-molecular-weight non-metabolizable amino acid. Following uptake, the AIB is released spontaneously from the cells. Treatment of cells with interferon reduced the AIB release. This effect was dosedependent, was neutralized by anti-interferon serum and was strongly reduced by trypsin treatment.
D000621:Aminoisobutyric Acids / Q000378:metabolism; D000650:Amnion / Q000166:cytology; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002463:Cell Membrane Permeability / Q000187:drug effects*; D002478:Cells, Cultured; D006801:Humans; D007372:Interferons / Q000494:pharmacology*; D007962:Leukocytes
D000621:Aminoisobutyric Acids; D007372:Interferons