[Noradrenaline uptake by the isolated hearts of rats adapted and dysadapted to hypoxia].
Disrupted training of rats for hypoxia during 3 weeks at the normal atmospheric pressure increases their resistance to the profound testing hypoxia. Stability of the noradrenaline (NA) level in conditions of isolated heart perfusion, a decrease in the NA neuronal uptake, and an increasing inhibitory effect of the exogenous NA on the synthesis of dioxyphenylalanine indicate an ample functional reserve in the adrenergic structures of these animals. A longer training (5 weeks) diminishing the resistance of rats to the testing hypoxic influence and entails phenomena of heart deadaptation at the level of its adrenergic structures.
D000222:Adaptation, Physiological; D000818:Animals; D004298:Dopamine / Q000378:metabolism; D006321:Heart / Q000294:innervation*; D000860:Hypoxia / Q000378:metabolism*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats
D004298:Dopamine; D009638:Norepinephrine
Zakhvat noradrenalina izolirovannym serdtsem krys adaptirovannykh i dizadaptirovannykh k gipoksii.