Penetration of tobramycin sulphate into the human eye.
Tobramycin sulphate, a new aminoglycoside antibiotic, was injected intramuscularly (80 and 100 mg) and subconjunctivally (10 mg) into patients, and the concentrations of the drug in serum and aqueous humour were determined 1 hour after the injection by an agar wall diffusion plate method. The intramuscular administration of tobramycin produced insignificant and non-inhibitory concentrations in the aqueous humour, while therapeutically effective levels of the antibiotic appeared in the aqueous after subconjunctival administrationof tobramycin (mean: 18.9 microgram/ml). These data suggest that tobramycin sulphate may be of value in the treatment of ocular infections.
D000368:Aged; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D001082:Aqueous Humor / Q000378:metabolism*; D003228:Conjunctiva; D006801:Humans; D007273:Injections, Intramuscular; D008875:Middle Aged; D014031:Tobramycin / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D014031:Tobramycin