Suppressive effect of 1,2-dibromo-3-chloropropane on human spermatogenesis.
Azoospermia was diagnosed in six factory workers who had been chronically exposed to 1,2-dibromo-3-chloropropane. Infertility was the presenting symptom in two patients and a decrease in libido or impotence characterized the others. Hormone studies revealed elevated plasma follicle-stimulating hormone levels and normal plasma luteinizing hormone and testosterone concentrations. Testicular biopsy showed selective atrophy of the germinal epithelium, intact Sertoli cells, and a normal appearance of a relatively increased number of Leydig cells.
D000328:Adult; D000969:Antinematodal Agents / Q000009:adverse effects*; D004781:Environmental Exposure; D006801:Humans; D006846:Hydrocarbons, Halogenated / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced; D009845:Oligospermia / Q000139:chemically induced* / Q000473:pathology; D011407:Propane / Q000009:adverse effects / Q000031:analogs & derivatives*; D013091:Spermatogenesis / Q000187:drug effects*; D013737:Testis / Q000473:pathology
D000969:Antinematodal Agents; D006846:Hydrocarbons, Halogenated; C007318:1,2-dibromo-3-chloropropane; D011407:Propane