Immunohistochemistry of human cutaneous sarcoidosis: a study of nine cases.
Biopsy specimens of sarcoid skin lesions from nine patients with sarcoidosis were examined for the presence of immunoglobulins, complement (C3 and C4), and fibrinogen. Granulomas in all skin lesions were positive only for fibrinogen. The literature relating to the immunohistochemistry of sarcoidosis is reviewed and its significance discussed.
D000328:Adult; D003176:Complement C3 / Q000032:analysis; D003181:Complement C4 / Q000032:analysis; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006099:Granuloma / Q000276:immunology* / Q000473:pathology; D006651:Histocytochemistry; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D008297:Male; D008875:Middle Aged; D012507:Sarcoidosis / Q000276:immunology* / Q000473:pathology; D012867:Skin / Q000032:analysis*; D012871:Skin Diseases / Q000276:immunology* / Q000473:pathology
D003176:Complement C3; D003181:Complement C4; D007136:Immunoglobulins; D005340:Fibrinogen