Concanavalin  A receptors in normal and inflamed oesophageal epithelium. A light and electron microscopic study.
We have examined normal and inflamed oesophageal biopsies for the distribution of alpha-D-mannosyl and alpha-D-glucosyl residues using the concanavalin A--horse radish peroxidase--Diamino-benzidine (DAB) technique at the light and electron microscope level. Receptors were found on the epithelial surface and in the nuclear membrane and endoplasmic reticulum. A similar distribution was found with the intrusive lymphocytes and polymorphonuclear leucocytes in the inflamed state. Some of the increased intercellular debris from inflamed biopsies contained concanavalin A receptors.
D001706:Biopsy; D002462:Cell Membrane / Q000032:analysis; D004721:Endoplasmic Reticulum / Q000032:analysis; D004848:Epithelium / Q000032:analysis; D004941:Esophagitis / Q000378:metabolism* / Q000473:pathology; D004947:Esophagus / Q000032:analysis*; D006651:Histocytochemistry; D006801:Humans; D008214:Lymphocytes / Q000032:analysis; D009504:Neutrophils / Q000032:analysis; D009685:Nuclear Envelope / Q000032:analysis; D011952:Receptors, Concanavalin A / Q000302:isolation & purification*; D011955:Receptors, Drug / Q000302:isolation & purification*
D011952:Receptors, Concanavalin A; D011955:Receptors, Drug