Urinary hydroxyproline excretion in acromegaly.
The urinary hydroxyproline excretion of 8 acromegalics kept on a collagen free diet has been studied. Urinary hydroxyproline showed a circadian rhythm with maximum excretion rates at night and early morning and minimum excretion rates in the late afternoon and evening. When mean values are compared, there is a significant correlation between fasting GH-levels and 24 h urinary hydroxyproline excretion (Rs = 0.74 and between GH and fasting hydroxyproline:creatinine ratios (Rs = 0.76). No significant correlation could be demonstrated between collagen content of bone biopsies and GH-levels or urinary hydroxyproline excretion. It is suggested that a practical assessment of disease activity in acromegaly can be achieved through a simplified hydroxyproline assay.
D000172:Acromegaly / Q000652:urine*; D000328:Adult; D002940:Circadian Rhythm; D003094:Collagen / Q000378:metabolism; D003404:Creatinine / Q000652:urine; D005215:Fasting; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D006909:Hydroxyproline / Q000652:urine*; D008297:Male; D008875:Middle Aged
D013006:Growth Hormone; D003094:Collagen; D003404:Creatinine; D006909:Hydroxyproline