Cellular mechanisms of fever and pasteurization: ATP depletion and RNA degradation in mouse L-cells at supra-optimal temperatures.
Supra-optimal temperatures have been found to reduce ATP concentrations within cells. This reduction depresses energy-dependent processes such as RNA synthesis, the rate of which may fall below that of its simultaneous breakdown resulting in excessive auto-digestion or cell death.
D000255:Adenosine Triphosphate / Q000378:metabolism*; D006358:Hot Temperature; D007739:L Cells / Q000378:metabolism*; D012313:RNA / Q000378:metabolism*; D013242:Sterilization
D012313:RNA; D000255:Adenosine Triphosphate