[Biochemical mechanisms of the action of cimetidine on the development of experimental stomach ulcers in rats].
In tests on rats with the use of the atom-absorption spectrophotometry a direct relation between the number of ulcerative lesion in the stomach, caused by immobilization, and the Ca2+ and Na+ content in the tissues of this organ was noted. The Ca2+ level declined propotrionally to the duration of the stress, viz. after a 1-hour long action-down to 76 per cent (9.9  micron/g) m after 4 hours-down to 65 per cent (7.7 micron/g) and with the calcium level in controls--11.8 micron/g. The Na+ content then increased, viz. after a 4-hour long immobilization is comprised 116 per cent (0.169 mM/g). The drug cimetidine prevented the development of lesions in the stomach and averted shifts in the content of ions in the tissues. The authors conclude that the fall of the Ca2+ ions in the tissues bears proof to a disturbed energy exchange in the cells and in this way contributes to the development of ulcerative lesions.
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002927:Cimetidine / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004734:Energy Metabolism / Q000187:drug effects; D005753:Gastric Mucosa / Q000378:metabolism; D006146:Guanidines / Q000627:therapeutic use*; D007103:Immobilization; D008297:Male; D051381:Rats; D012964:Sodium / Q000378:metabolism; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000378:metabolism; D013997:Time Factors
D006146:Guanidines; D002927:Cimetidine; D012964:Sodium; D002118:Calcium
Biokhimicheskie mekhanizmy deĭstviia tsimetidina na razvitie éksperimental'nykh iazv zheludka u krys.