Therapy with essential amino acids and their nitrogen-free analogues in severe renal failure.
The effects of therapy with essential amino acids and their nitrogen-free hydroxy and keto precursers on nitrogen and amino acid metabolism of patients with chronic renal failure were examined. Data obtained under treatment with essential amino acids and alpha-keto acid analogues showed higher levels of plasma amino acids, C3-complement, and transferrin than with a low-protein diet alone. Nitrogen balance became positive and plasma urea levels fell. With keto acid analogue therapy, these effects could be obtained with a reduced nitrogen intake. Supplementation of a low protein diet with alpha-hydroxy acid analogues was associated with more positive nitrogen balance and a rise in plasma histidine and methionine. However, plasma levels of three other essential amino acids fell.
D000596:Amino Acids / Q000097:blood; D000601:Amino Acids, Essential / Q000627:therapeutic use*; D003176:Complement C3 / Q000378:metabolism; D004044:Dietary Proteins / Q000008:administration & dosage; D006801:Humans; D006880:Hydroxy Acids / Q000627:therapeutic use*; D007651:Keto Acids / Q000627:therapeutic use*; D007676:Kidney Failure, Chronic / Q000178:diet therapy*; D009584:Nitrogen / Q000378:metabolism; D014168:Transferrin / Q000378:metabolism; D014508:Urea / Q000097:blood
D000596:Amino Acids; D000601:Amino Acids, Essential; D003176:Complement C3; D004044:Dietary Proteins; D006880:Hydroxy Acids; D007651:Keto Acids; D014168:Transferrin; D014508:Urea; D009584:Nitrogen