The metabolism and active excretion of the hypoxanthine by the renal tubules in the chicken.
Infusion of [14C]hypoxanthine into one renal portal circulation of the chicken resulted in an excess of [14C]uric acid excreted into the urine from the infused side kidney. No [14C]hypoxanthine appeared in the urine from either kidney. When the renal metabolism of [14C]hypoxanthine was inhibited by xanthine dehydrogenase inhibitors, almost no excess 14C-label appeared in the urine of the infused side suggesting that formation of nephrogenic urate plays an important role in the tubular excretion of hypoxanthine. A comparison of the effects of inhibitors on the renal excretion of preformed urate and nephrogenic urate suggests the existence of a p-aminohippurate-independent transport step for purines at the luminal membrane of the renal tubular cell. Studies with transport inhibitors suggest that the active transport step is anionic in character.
D000493:Allopurinol / Q000494:pharmacology; D000818:Animals; D002645:Chickens; D005260:Female; D007042:Hypoxanthines / Q000378:metabolism* / Q000652:urine; D007668:Kidney / Q000378:metabolism*; D007684:Kidney Tubules / Q000378:metabolism; D010117:Oxypurinol / Q000494:pharmacology; D011339:Probenecid / Q000494:pharmacology; D011803:Quinine / Q000494:pharmacology; D010130:p-Aminohippuric Acid / Q000494:pharmacology
D007042:Hypoxanthines; D000493:Allopurinol; D011803:Quinine; D010117:Oxypurinol; D011339:Probenecid; D010130:p-Aminohippuric Acid