General resorption of intravesically instilled 5-fluorouracil.
To evaluate the resorption of intravesically instilled 5-fluorouracil a single dose of 250 or 1,000 mg. was injected into the empty bladder for 3 hours in 17 patients. The concentration of 5-fluorouracil in serum during instillation was recorded. A microbiologic agar plate method was used for the assay. No measurable 5-fluorouracil concentrations were recorded in the systemic blood of patients with undamaged bladder mucosa and low levels (less than 100 ng./ml. serum) of 5-fluorouracil were found in the systemic circulation of patients with mucosal lesions.
D000368:Aged; D005472:Fluorouracil / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism* / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000378:metabolism
D005472:Fluorouracil