Tropomyosin inhibits the interaction of F-actin and filamin.
The value of flow birefringence of F-actin was greatly decreased by filamin due to precipitate formation. This precipitate could be dispersed into birefringent filaments by sonication. Tropomyosin inhibited precipitation of F-actin induced by filamin, and no decrease in birefringence occurred when filamin was added to tropomyosin-bound F-actin. Hence it appears that filamin acts on F-actin in non-muscle cells similarly to alpha-actinin.
D000199:Actins; D001718:Birefringence; D003285:Contractile Proteins; D007700:Kinetics; D011485:Protein Binding; D013010:Sonication; D014335:Tropomyosin
D000199:Actins; D003285:Contractile Proteins; D014335:Tropomyosin