Decentralization supersensitivity in headache and central panalgesia.
Central panalgesia is a syndrome which includes systemic pains of a central nature, usually classified as hysteria, fibrositis and masked depression. Exploration of the peripheral neuromuscular junctions (in the iris by pupillometry, and in veins by computerized venotest) indicates an increased monoamine receptor sensitivity. 5-HT vein sensitivity is particularly impressive (up to 1,000 times). In the vein there appears to be a decentralization supersensitivity, as it is extended to different monoamines (5-HT, dopamine, noradrenaline, tyramine). This type of supersensitivity is compatible with the theory of a deficiency of neurotransmitters at the level of the anti-nociceptive and integrated systems, with subsequent central and peripheral supersensitivity. A similar condition limited to the rostral section of the anti-nociceptive system is valid for the mechanism of idiopathic headache including migraine: central and peripheral supersensitivity to monoamines and opiates is also episodically observed in headache sufferers.
D001058:Apomorphine / Q000009:adverse effects; D001921:Brain / Q000187:drug effects; D004298:Dopamine / Q000009:adverse effects; D004342:Drug Hypersensitivity / Q000150:complications*; D006261:Headache / Q000209:etiology*; D006801:Humans; D008881:Migraine Disorders / Q000209:etiology; D009638:Norepinephrine / Q000009:adverse effects; D010423:Pentazocine / Q000009:adverse effects; D012701:Serotonin / Q000009:adverse effects
D012701:Serotonin; D001058:Apomorphine; D010423:Pentazocine; D004298:Dopamine; D009638:Norepinephrine