Problems in the kinetic evaluation of capacity-limited processes by means of the analog computer MEDA 82 T.
A method for the calculation of dose-dependent pharmaco-kinetics by means of a combined zero and first-order model at the analog computer is presented. The results of the combined model can be converted into Michaelis-Menten parameters using simple equations. The method is usable for i.v. injection and for e.v. modes of application in the case of cmax greater than c = co/e.
D003202:Computers, Analog; D006207:Half-Life; D006801:Humans; D007408:Intestinal Absorption; D007700:Kinetics; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D010672:Phenytoin / Q000097:blood
D004364:Pharmaceutical Preparations; D010672:Phenytoin