[Heparin in the prevention of thromboembolism after elective hip-joint operations (author's transl)].
Using the 125I-fibrinogen test, the antithrombotic effect of three different heparin schedules was examined in 113 patients untergoing elective hip surgery. Low-dose heparin (3 X 5000 IU/24 h) reduced the incidence of postoperative thrombosis from 60% in the control subjects (not receiving any heparin) to 33%. Combined low-dose heparin and acetylsalicyl-lysine, given intravenously, further reduced the incidence slightly to 27%. Increasing the heparin dosage postoperatively to 3 X 7500 IU/24 h effectively prevented the incidence of thrombosis by reducing it to 11% in these high-risk patients.
D001241:Aspirin / Q000031:analogs & derivatives / Q000627:therapeutic use; D005260:Female; D005860:Germany, West; D006493:Heparin / Q000008:administration & dosage / Q000627:therapeutic use*; D006621:Hip Joint / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011655:Pulmonary Embolism / Q000517:prevention & control; D013923:Thromboembolism / Q000517:prevention & control*; D013924:Thrombophlebitis / Q000453:epidemiology
D006493:Heparin; D001241:Aspirin
Thromboembolieprophylaxe mit Heparin bei elektiven Hüftgelenksoperationen.