The mechanism of haem degradation in vitro. Kinetic evidence for the formation of a haem-oxygen complex.
The rate of haem degradation in aqueous pyridine shows a saturation dependence on O2 concentration. CO competitively inhibits the reaction. This is evidence for formation of an iron-O2 complex and is consistent with an intramolecular pathway for haem degradation.
D002248:Carbon Monoxide / Q000097:blood; D006418:Heme / Q000378:metabolism*; D007700:Kinetics; D010084:Oxidation-Reduction; D010100:Oxygen / Q000097:blood*
D006418:Heme; D002248:Carbon Monoxide; D010100:Oxygen