[State of protein and mineral metabolism following thyrocalcitonin administration during experimental osteogenesis].
Prolonged administration of thyrocalcitonine (TC) into rats (at a dose 5 un per animal) led to some alterations in protein and mineral metabolism: decrease in content of calcium and phosphorus in blood, activation of alkaline phosphatase in blood, decrease in excretion of hydroxyproline, increase in excretion of aminonitrogen with urine. Distinct correlation was observed between the metabolic activity and definite steps in reparative osteogenesis. Exogenous TC activated the cellular structures, which participated in the regenerative processes, promoted the rapid turnover of bone generation and decreased the periods of tracture healing.
D000469:Alkaline Phosphatase / Q000097:blood; D000588:Amines / Q000652:urine; D000818:Animals; D002116:Calcitonin / Q000627:therapeutic use*; D002118:Calcium / Q000097:blood; D050723:Fractures, Bone / Q000188:drug therapy* / Q000378:metabolism; D006909:Hydroxyproline / Q000652:urine; D008903:Minerals / Q000378:metabolism*; D010758:Phosphorus / Q000097:blood; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D014945:Wound Healing / Q000187:drug effects
D000588:Amines; D008903:Minerals; D011506:Proteins; D010758:Phosphorus; D002116:Calcitonin; D000469:Alkaline Phosphatase; D006909:Hydroxyproline; D002118:Calcium
Sostoianie belkovogo i mineral'nogo obmena pri vvedenii tirokal'tsitonina v usloviiakh éksperimental'nogo osteogeneza.