[Effect of protracted infusions of polyglucin during the resuscitation period on metabolic and morphologic characteristics of the brain].
Polyglucine infusions (10 ml/kg) during the first 10 days of postresuscitation period after 4-hour hypovolemic hypotension promotes normalization of general RNA content, quick mobile protein fractions, corresponding prealbumins, albumins, postalbumins, ceruloplasmin, transferrin, and alpha-globulins. Macromolecular protein fractions beta- and gamma-globulins--remained considerably changed: beta-globulins doubled, and gamma-globulins decreased 1.7-fold. Acid phosphatase specific activity increased in the postmitochondrial supernatant by 53%; an increase in the acid phosphatase activity was revealed in the neurons, glia, and vascular endothelium. The amount of Purkinje's cells in the cerebral cortex in the experimental group did not differ essentially from the control values. Thus, the results obtained emphasize the importance of prolonged polyglucine infusions together with other resuscitation measures in the treatment of hypovolemic states.
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D001927:Brain Diseases / Q000517:prevention & control*; D002540:Cerebral Cortex / Q000032:analysis* / Q000201:enzymology; D004247:DNA / Q000032:analysis; D003911:Dextrans / Q000008:administration & dosage*; D004285:Dogs; D005260:Female; D006651:Histocytochemistry; D008297:Male; D009419:Nerve Tissue Proteins / Q000032:analysis; D012313:RNA / Q000032:analysis; D012151:Resuscitation
D003911:Dextrans; D009419:Nerve Tissue Proteins; D012313:RNA; D004247:DNA; D000135:Acid Phosphatase
Vliianie prodolzhitel'nykh infuzii poligliukina v postreanimatsionnom periode na metabolicheskie i morfologicheskie kharakteristiki mozga.