Inhibition of platelet aggregation by alpha-tocopherol and its nicotinate and acetate esters.
Two esters of vitamin E, dl-a-tocopheryl nicotinate and dl-a-tocopheryl acetate were found to be more inhibitors than tocopherol itself on platelet aggregation induced by arachidonic acid and collagen. The nicotinate was 1--5 times more potent than the acetate and 2--18 times more potent than the unesterified tocopherol in inhibiting collagen induced aggregation in human citratet platelet-rich plasma.
D001095:Arachidonic Acids / Q000378:metabolism / Q000494:pharmacology; D003094:Collagen / Q000494:pharmacology; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects*; D014810:Vitamin E / Q000494:pharmacology*
D001095:Arachidonic Acids; D014810:Vitamin E; D003094:Collagen