Aconitase (E.C. 4.2.1.3) mitochondrial locus mapped to human chromosome 22: studies with Chinese hamster--human somatic cell hybrids.
Three separate somatic cell fusions were made between Chinese hamster lines and human lymphocytes containing (1) a 3/4 translocation, (2) an X/9 translocation, and (3) a 17/9 translocation. Eleven independently derived hybrids showed that only human chromosome 22 was consistently present when human ACONM was expressed and absent when human ACONM was not expressed. These studies assign a gene for human ACONM to chromosome 22, and are consistent with prior gene-mapping results.
D000154:Aconitate Hydratase / Q000235:genetics*; D002460:Cell Line; D002904:Chromosomes, Human, 21-22 and Y; D006801:Humans; D006822:Hybrid Cells / Q000201:enzymology; D008928:Mitochondria / Q000201:enzymology*
D000154:Aconitate Hydratase