Bilary lipids and bile acid pool size after vagotomy in man. Evidence against a predisposition to gallstones.
Eight male subjects who had previously undergone vagotomy and pyloroplasty were found to have significantly larger bile acid pools than did a group of matched control subjects. Associated with these expanded pools was a significantly lower molar per cent cholesterol of gallbladder bile in the vagotomy group. These findings are the opposite of those expected in a group predisposed to cholesterol cholelithiasis, suggesting that vagotomy, at least in males, does not predispose to cholesterol gallstones. If such stones form after vagotomy, they presumably do so by a mechanism not presently appreciated.
D001646:Bile / Q000032:analysis; D001647:Bile Acids and Salts / Q000378:metabolism*; D002635:Chenodeoxycholic Acid / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D003840:Deoxycholic Acid / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism; D008297:Male; D012306:Risk; D014628:Vagotomy / Q000009:adverse effects*
D001647:Bile Acids and Salts; D003840:Deoxycholic Acid; D002635:Chenodeoxycholic Acid; D002784:Cholesterol