Influence of polyphloretin phosphate (PPP) on rat-paw oedema induced by prostaglandin E1 (PGE1).
As a result of pretreatment with the known prostaglandin antagonist polyphloretin phosphate (50, 100 or 200 mg/kg i.v.), there is a statistically significant decrease in the magnitude of the oedema induced in Sprague-Dawley CFY rats by the subplantar administration of 1 microgram prostaglandin E1.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D010693:Phloretin / Q000031:analogs & derivatives*; D011121:Polyphloretin Phosphate / Q000627:therapeutic use*; D011458:Prostaglandins E / Q000008:administration & dosage; D051381:Rats
D011458:Prostaglandins E; D011121:Polyphloretin Phosphate; D010693:Phloretin