[Experimental study on the abortive effects of chlorinated hydrocarbon anaesthetics (author's transl)].
The effects of inhalation anaesthetics derived from chlorinated hydrocarbons (halothane, ethrane, penthrane) on foetal development were studied in pregnant rats. Administration of the anaesthetics during the main organogenetic stage did not affect foetal development; but application during the embryonic stage resulted in increased incidence of intra-uterine deaths and difficult deliveries. No malformations were observed.
D000022:Abortion, Spontaneous / Q000139:chemically induced*; D000777:Anesthetics / Q000009:adverse effects*; D000818:Animals; D005260:Female; D005333:Fetus / Q000187:drug effects*; D005865:Gestational Age; D006843:Hydrocarbons, Chlorinated / Q000009:adverse effects* / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D011247:Pregnancy; D051381:Rats; D013997:Time Factors
D000777:Anesthetics; D006843:Hydrocarbons, Chlorinated
Vergleichende tierexperimentelle Untersuchungen über die abortive Wirkung chlorierter Kohlenwasserstoffinhalationsnarkotika.