Tissue distribution and nucleic acid binding of chlorambucil-3H in tumor-bearing rats.
In tumour and normal rat tissues prolonged alkylation of DNA and RNA by chlorambucil-3H occurs over periods of 24 h. It is suggested that this may indicate the slow release of an alkylating moiety from an intracellular drug-macromolecule complex.
D000478:Alkylation; D000818:Animals; D002699:Chlorambucil / Q000378:metabolism / Q000494:pharmacology*; D004247:DNA / Q000378:metabolism; D004273:DNA, Neoplasm / Q000378:metabolism*; D005260:Female; D009374:Neoplasms, Experimental / Q000378:metabolism; D012313:RNA / Q000378:metabolism; D012334:RNA, Neoplasm / Q000378:metabolism*; D051381:Rats; D014018:Tissue Distribution
D004273:DNA, Neoplasm; D012334:RNA, Neoplasm; D002699:Chlorambucil; D012313:RNA; D004247:DNA