title: Calcium-dependent increase in spike duration during repetitive firing of Aplysia axon in the presence of TEA.
abstract: Repetitive stimulation was studied in the axon of the giant neuron, R2, of Aplysia in the presence of TEA. In 25 or 50 mM extracellular TEA, a plateau develops on the axon spike during repetitive stimulation at frequencies greater than 3/sec. The plateau in extracellular TEA is inhibited by 30 mM CoCl2 or 1 mM CdCl2, and is enhanced by raising the Ca concentration. Intracellular TEA induces a plateau on the axon spike at frequencies less than 1/30sec. This plateau increases in duration with repetitive stimulation at higher frequencies and is inhibited by 30 mM CoCl2 or 1 mM CdCl2. The increase in spike duration during repetitive firing in the presence of TEA is indicative of an increased entry of Ca during the spike train.
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001048:Aplysia / Q000187:drug effects / Q000502:physiology*; D001369:Axons / Q000187:drug effects / Q000502:physiology*; D002104:Cadmium / Q000494:pharmacology; D002118:Calcium / Q000502:physiology*; D003035:Cobalt / Q000494:pharmacology; D066298:In Vitro Techniques; D007478:Iontophoresis; D013757:Tetraethylammonium Compounds / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D013757:Tetraethylammonium Compounds; D002104:Cadmium; D003035:Cobalt; D002118:Calcium