[Effect of amidine and guanidine derivatives on thrombocyte aggregation].
The capacity of 25 different amidines, guanidines and biguanidines to suppress the thrombocytes aggregation, induced by adenosinodiphosphate, was studied. Good prospects of a search for antiaggregation agents in this series of compounds are shown. N-benzyl-N1-propionylguanidine was found to reduce by more than 4 times the induced adhesiveness of the blood platelets.
D000578:Amidines / Q000494:pharmacology*; D000818:Animals; D006146:Guanidines / Q000494:pharmacology*; D006571:Heterocyclic Compounds; D010974:Platelet Aggregation / Q000187:drug effects*; D011817:Rabbits; D013329:Structure-Activity Relationship
D000578:Amidines; D006146:Guanidines; D006571:Heterocyclic Compounds
Vliianie proizvodnykh amidina i guanidina na agregatsiiu trombotsitov.