title: Inhibition by lymphoblastoid interferon of growth of cells derived from the human breast.
abstract: Human lymphoblastoid interferon inhibited the growth in vitro of fibroblasts and epithelial cells from normal, hyperplastic and neoplastic human breast tissue. At an interferon concentration of 10(3) inter-national units (IU) per ml, the inhibitory effects on monolayer growth were completely reversible but the growth potential of cells at lower density in colony-forming cultures was not completely recovered. Studies on the cell cycle distribution of interferon-treated cells demonstrated that the growth-inhibitory effect was not due to an effect on one specific phase of the cell cycle, but to a lengthening of all phases.
mesh_terms: D001940:Breast / Q000166:cytology / Q000187:drug effects*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D002453:Cell Cycle / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002999:Clone Cells / Q000187:drug effects; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000188:drug therapy; D007372:Interferons / Q000302:isolation & purification / Q000494:pharmacology*; D007700:Kinetics; D008214:Lymphocytes / Q000276:immunology; D009374:Neoplasms, Experimental / Q000188:drug therapy
chemical_list: D007372:Interferons