[Metabolism of homocarnosine and gamma-amino butyric acid in different regions of rat brain under hyperoxia].
The content of homocarnosine, GAMA, histidine, glutaminic acid and activity of glutamate decarboxylase were studied in four regions of rats brain: cerebral hemispheres, midbrain, diencephalon and cerebellum, in norm and under hyperoxia. A considerable decrease in the content of homocarnosine, GAMA and histidine is observed in all the studied regions of the rat brain in the convulsion stage of oxygen poisoning. A decrease in the glutamate  decarboxylase activity is the reason for a drop in the GAMA content. Homocarnosine in the brain is bound functionally with the GAMA level.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002336:Carnosine / Q000031:analogs & derivatives / Q000378:metabolism*; D002531:Cerebellum / Q000378:metabolism; D004027:Diencephalon / Q000378:metabolism; D004151:Dipeptides / Q000378:metabolism*; D006639:Histidine / Q000378:metabolism; D006931:Hyperbaric Oxygenation; D008636:Mesencephalon / Q000378:metabolism; D051381:Rats; D014018:Tissue Distribution; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D004151:Dipeptides; C005038:homocarnosine; D006639:Histidine; D005680:gamma-Aminobutyric Acid; D002336:Carnosine
Obmen gomokarnozina i gamma-aminomaslianoĭ kisloty v razlichnykh otdelakh mozga krys pri giperoksii.