Duchenne dystrophy: focal alterations in the distribution of concanavalin A binding sites at the muscle cell surface.
In 6 patients with Duchenne dystrophy, electron microscopical studies of concanavalin A (Con A) binding sites using the peroxidase labeling technique revealed a population of muscle fibers in which the reaction at the cell surface was irregular and patchy in areas larger than 0.5 mu. In 5 control subjects,  such focal alterations were not observed and the reaction appeared continuous and regular. The findings indicate focal abnormalities at the muscle cell surface of Con A receptors in Duchenne dystrophy.
D000328:Adult; D002462:Cell Membrane / Q000648:ultrastructure; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009132:Muscles / Q000648:ultrastructure*; D009136:Muscular Dystrophies / Q000473:pathology*; D011952:Receptors, Concanavalin A; D011955:Receptors, Drug
D011952:Receptors, Concanavalin A; D011955:Receptors, Drug