Anticholeretic effect of somatostatin in anesthetized dogs.
Somatostatin, 0.2-1.0 microgram . kg-1 . min-1, was administered i.v. in 5 anesthetized dogs. Following 9-min infusions, hepatic bile output was found to decrease by approximately 50% after a latency of 6 min. The mode of action suggests that somatostatin inhibits hormone-induced bile output.
D000818:Animals; D001646:Bile / Q000378:metabolism*; D003864:Depression, Chemical; D004285:Dogs; D007263:Infusions, Parenteral; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D013004:Somatostatin / Q000008:administration & dosage / Q000494:pharmacology*
D013004:Somatostatin