title: 1-methyl and 1-benzyl derivatives of tetrahydroisoquinoline inhibit 5-hydroxytryptamine uptake by human blood platelets.
abstract: The effect of 1-methyl (salsoline, salsolidine) and 1-benzyl (papaverine) derivatives of tetrahydroisoquinoline (TIQ) on 5-hydroxytryptamine (5-HT) uptake by human blood platelets was studied. The drugs tested inhibited 5-HT (3 X 10(-6)M 5 min incubation) uptake by 30--60 % at 10(-4)M concentration and by 20--25 % at 10(-5)M concentration.
mesh_terms: D001792:Blood Platelets / Q000378:metabolism*; D003864:Depression, Chemical; D006801:Humans; D007546:Isoquinolines / Q000494:pharmacology*; D010208:Papaverine / Q000494:pharmacology*; D012490:Salsoline Alkaloids / Q000494:pharmacology*; D012701:Serotonin / Q000097:blood*
chemical_list: D007546:Isoquinolines; D012490:Salsoline Alkaloids; D012701:Serotonin; D010208:Papaverine