[DNA replication in HeLa cells after gamma irradiation. II. The periodicity of DNA replication in the process of giant cell formation].
HeLa G-63 cells irradiated by 5 krads of 6 degrees Co gamma-rays 1.5--2 hours after mitosis (G1-phase) were incubated in growth medium during 9 days. The number of proliferating and eliminated cells, the content of DNA per cell nucleus, and kinetics of the labeled cell fraction upon 3H-TdR continuous incubation were studied. It has been concluded that: during the giant cell growth the nuclear DNA is replicated periodically without following mitoses; 90% of cells are involved in such a cycle; the duration of the period of DNA synthesis in giant cells is the same as that in non-irradiated cells; the duration of the gap between two successive S-periods in giant cells is 2--6 times as long as the sum of G2+M+G1 periods in the normal non-irradiated cells.
D002455:Cell Division / Q000528:radiation effects; D004261:DNA Replication / Q000528:radiation effects*; D005720:Gamma Rays; D006367:HeLa Cells / Q000528:radiation effects*; D007399:Interphase / Q000528:radiation effects; D008433:Mathematics; D008954:Models, Biological; D010507:Periodicity
Replikatsiia DNK v kletkakh HeLa posle gamma-oblucheniia. II. Periodichnost' replikatsii DNK v protsesse obrazovaniia gigantskikh kletok.