title: Aluminium phosphate but not calcium phosphate stimulates the specific IgE response in guinea pigs to tetanus toxoid.
abstract: The ability of aluminium phosphate and calcium phosphate to stimulate the synthesis of tetanus toxoid-specific anaphilactic and antitoxic antibodies is compared. The observed differences in the kinetics of IgG1a, IgG1b and antitoxines are quantitative--titres after application of aluminium phosphate are higher. Booster immunization with aluminium but not calcium phosphate-adsorbed toxoid leads to a prolonged synthesis of specific IgE. It is hypothesized that the regular application of aluminium compound-containing vaccines on the entire population could be one of the factors leading to the observed increase of allergic diseases.
mesh_terms: D000535:Aluminum / Q000494:pharmacology*; D000707:Anaphylaxis / Q000276:immunology; D000818:Animals; D000917:Antibody Formation; D000918:Antibody Specificity; D002130:Calcium Phosphates / Q000494:pharmacology*; D006168:Guinea Pigs; D007073:Immunoglobulin E / Q000096:biosynthesis*; D007074:Immunoglobulin G / Q000096:biosynthesis; D007700:Kinetics; D008297:Male; D010710:Phosphates / Q000494:pharmacology*; D013745:Tetanus Toxoid / Q000276:immunology*
chemical_list: D002130:Calcium Phosphates; D007074:Immunoglobulin G; D010710:Phosphates; D013745:Tetanus Toxoid; D007073:Immunoglobulin E; D000535:Aluminum