Early intermediates in the biosynthesis of ansamycins. I. Isolation and identification of protorifamycin I.
A mutant strain derived from Nocardia mediterranei N813 was found to accumulate a number of novel ansamycins structurally related to the protostreptovaricins and to rifamycin W. One of the main components of this ansamycin complex, protorifamycin I (8-deoxyrifamycin W), was purified and identified by means of chemical and spectroscopic methods.
D055598:Chemical Phenomena; D002621:Chemistry; D005285:Fermentation; D008826:Microbial Sensitivity Tests; D009154:Mutation; D009615:Nocardia / Q000235:genetics / Q000378:metabolism; D012294:Rifamycins / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology
D012294:Rifamycins