Immunoadjuvant effects of the synthetic muramyl-dipeptide (MDP) N-acetylmuramyl-L-alanyl-D-isoglutamine.
The adjuvant activity of the synthetic muramyl-dipeptide (MDP) N-acetyl-muramyl-L-alanyl-D-isoglutamine upon immunization of mice with BSA or SRBC was studied. MDP was found to significantly increase BSA-antibody formation and to favour the induction of anaphylactic reactions to BSA. In contrast, under the conditions employed, MDP only weakly stimulated the immune response to SRBC.
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000276:immunology*; D000276:Adjuvants, Immunologic; D000707:Anaphylaxis; D000818:Animals; D000941:Antigens; D004912:Erythrocytes / Q000276:immunology; D006020:Glycopeptides / Q000276:immunology*; D007114:Immunization; D051379:Mice; D012710:Serum Albumin, Bovine
D000276:Adjuvants, Immunologic; D000941:Antigens; D006020:Glycopeptides; D012710:Serum Albumin, Bovine; D000119:Acetylmuramyl-Alanyl-Isoglutamine