In vitro studies of the interaction between ascorbic acid and rat tail tendon.
Ascorbic acid (in its normal and oxidised forms) enhances the mechanical and thermal stability of rat tail tendon. Its effectiveness increases with the concentration but levels off at a value approximately 5 times normal physiological concentration (1--2 mg/100 ml). An analogue, D-isoascorbic acid is also effective, but to a lesser extent. There is some evidence that it reduces reducible aldimine links, especially in young tissues. However, for the most part, its effects are reversible.
D000375:Aging; D000818:Animals; D001205:Ascorbic Acid / Q000031:analogs & derivatives / Q000494:pharmacology*; D051381:Rats; D013314:Stress, Mechanical; D013710:Tendons / Q000187:drug effects / Q000254:growth & development / Q000502:physiology*
D001205:Ascorbic Acid