Hypothalamic hypothyroidism causing spastic paraplegia: recovery following thyroid medication.
A 63-year-old woman with longstanding spastic paraplegia and neurological evidence of long tract disturbance was found to have hypothyroidism, partial diabetes insipidus, hyperprolactinemia, and gonadotropin deficiency of hypothalamic origin. Replacement therapy with thyroxine and prednisone induced complete remission of the neurological abnormalities. The association of spastic paraplegia with hypothalamic insufficiency  has not been reported previously. The possibility of hypothalamic disease should be considered in cases of spastic paraplegia of unknown cause.
D001927:Brain Diseases / Q000150:complications / Q000628:therapy; D003919:Diabetes Insipidus / Q000150:complications; D005260:Female; D006801:Humans; D007031:Hypothalamus; D007037:Hypothyroidism / Q000150:complications* / Q000188:drug therapy / Q000209:etiology; D008875:Middle Aged; D009128:Muscle Spasticity / Q000209:etiology / Q000628:therapy; D010264:Paraplegia / Q000209:etiology* / Q000628:therapy; D013974:Thyroxine / Q000627:therapeutic use
D013974:Thyroxine