title: Quantitative aspects of contrast enhancement in cranial computed tomography.
abstract: The temporal relationship of blood iodine levels to tumor enhancement in cranial computed tomography was studied in a series of patients. Both the bolus and biphasic techniques were evaluated. Peak tumor intensity may not develop immediately, but may be more pronounced on a 20-minute scan. The low-density centers seen in malignant gliomas show delayed enhancement. These low-density centers represent a second compartment which equilibrates with the intravascular and interstitial contrast material at a much slower rate. Patients with malignant gliomas can be scanned up to one hour following contrast injection without significant loss of information.
mesh_terms: D001812:Blood-Brain Barrier; D001932:Brain Neoplasms / Q000097:blood / Q000000981:diagnostic imaging*; D003287:Contrast Media / Q000008:administration & dosage; D005910:Glioma / Q000097:blood / Q000000981:diagnostic imaging*; D006801:Humans; D007275:Injections, Intravenous; D007455:Iodine / Q000008:administration & dosage / Q000097:blood; D007482:Iothalamate Meglumine / Q000008:administration & dosage; D010539:Permeability; D011856:Radiographic Image Enhancement; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media; D007455:Iodine; D007482:Iothalamate Meglumine