Enhancement of melphalan therapy with glutaminase:asparaginase.
Depletion of glutamine with Acinetobacter glutaminase:asparaginase promotes melphalan uptake by and cytotoxicity to murine L1210 cells in vitro. Combined treatment of tumor bearing mice with these two agents increases the therapeutic response.
D000150:Acinetobacter / Q000201:enzymology; D000818:Animals; D001215:Asparaginase / Q000627:therapeutic use*; D001216:Asparagine / Q000494:pharmacology; D004357:Drug Synergism; D005972:Glutaminase / Q000627:therapeutic use*; D005973:Glutamine / Q000494:pharmacology; D007939:Leukemia L1210 / Q000188:drug therapy*; D008558:Melphalan / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D051379:Mice; D013997:Time Factors
D005973:Glutamine; D001216:Asparagine; D001215:Asparaginase; D005972:Glutaminase; D008558:Melphalan