title: In vitro studies of the interaction between ascorbic acid and rat tail tendon.
abstract: Ascorbic acid (in its normal and oxidised forms) enhances the mechanical and thermal stability of rat tail tendon. Its effectiveness increases with the concentration but levels off at a value approximately 5 times normal physiological concentration (1--2 mg/100 ml). An analogue, D-isoascorbic acid is also effective, but to a lesser extent. There is some evidence that it reduces reducible aldimine links, especially in young tissues. However, for the most part, its effects are reversible.
mesh_terms: D000375:Aging; D000818:Animals; D001205:Ascorbic Acid / Q000031:analogs & derivatives / Q000494:pharmacology*; D051381:Rats; D013314:Stress, Mechanical; D013710:Tendons / Q000187:drug effects / Q000254:growth & development / Q000502:physiology*
chemical_list: D001205:Ascorbic Acid