title: Isolation of a hypotensive substance from seeds of Casimiroa edulis.
abstract: The hypotensive activity of the alcoholic and aqueous extracts of C. edulis has been previously reported. The present paper describes the pharmacological studies of a substance isolated from the alcoholic extract. Preliminary chemical and pharmacological data allowed a histamine-like compound to be proposed as the hypotensive principle. Studies were performed by means of in vitro and in vivo animal experiments.
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects*; D004285:Dogs; D006168:Guinea Pigs; D006973:Hypertension / Q000188:drug therapy; D010936:Plant Extracts / Q000032:analysis*; D012639:Seeds / Q000032:analysis*
chemical_list: D000959:Antihypertensive Agents; D010936:Plant Extracts