[Effect of insulin and prednisolone on the transport of organic substances in the kidneys of dogs].
Single injection of insulin (1 AU/kg) enhanced maximal glucose absorption, cardiotrast secretion and decreased sodium excretion without any changes of glomerular filtration in dogs. These effects depended on the direct action of insulin so far as the effect is expressed in the kidney only at the side of infusion when the preparation is administered into one of the renal arteries. Prednisolone had no significant effect on the glucose and cardiotrast transport in single injection (3--4 mg/kg) and 10-day (1.5--2 mg/kg daily) injections.
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D004231:Diuresis / Q000187:drug effects; D004285:Dogs; D005919:Glomerular Filtration Rate / Q000187:drug effects; D005947:Glucose / Q000378:metabolism*; D007328:Insulin / Q000494:pharmacology*; D007468:Iodopyracet / Q000378:metabolism*; D007668:Kidney / Q000187:drug effects*; D009318:Natriuresis / Q000187:drug effects; D011188:Potassium / Q000652:urine; D011239:Prednisolone / Q000494:pharmacology*
D007328:Insulin; D011239:Prednisolone; D005947:Glucose; D011188:Potassium; D007468:Iodopyracet
Vliianie insulina i prednisolona na transport organicheskikh veshchestv v pochkakh sobak.