Baroreflex function in uremic and hypertensive man.
Human hypertension has been related to abnormalities of autonomic blood pressure regulation. In order to characterize a possible defect, we have studied several aspects of reflex autonomic circulatory control in normal subjects, patients with primary hypertension, and two types of subjects with uremia and elevated blood pressure. Phenylephrine infusion (a measurement of baroreceptor response to high pressure stimulus) resulted in similar hemodynamic changes in all types of subjects. However, all groups of patients exhibited significantly different hemodynamic responses to amyl nitrite inhalation (an index of baroreceptor response to low pressure stimulus). These results suggest that patients with uremia and those with primary hypertension differ from each other and normal subjects regarding baroreceptor reflex function. Furthermore, one type of uremic patient may have a neurogenic component to their hypertension similar to experimental animals following surgical section of afferent baroreceptor nerves.
D000328:Adult; D000680:Amyl Nitrite / Q000008:administration & dosage / Q000494:pharmacology; D000804:Angiotensin II / Q000096:biosynthesis; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010656:Phenylephrine / Q000494:pharmacology; D011311:Pressoreceptors / Q000187:drug effects / Q000503:physiopathology; D011312:Pressure; D012018:Reflex / Q000187:drug effects / Q000502:physiology*; D012083:Renin / Q000097:blood; D014511:Uremia / Q000503:physiopathology*; D014655:Vascular Resistance / Q000187:drug effects
D000804:Angiotensin II; D010656:Phenylephrine; D000680:Amyl Nitrite; D012083:Renin