[Growth control of experimental tumour. I. Host protection against tumour by previous inoculation of plasmatic membrane of tumour cell (author's transl)].
Proteins from plasmatic membrane of ascites and solid 20-methylcholantrene induced tumours cells in inbred mice and rats were obtained by isolation of vesicles of tumor cell membranes produced in glycerol solution. The tumour cells were not broken. In a syngeneic system the inoculation of the prepared protein with adjuvant resulted in protection of 50 to 100% of animals against challenge with a syngeneic tumour cells. The same results were obtained with Ehrlich ascites tumour. The lymphocyte cytotoxicity and blastic transformation of lymphocytes in immunized animals suggested a cellular cytotoxic immunity mediated by tumour specific antigen or perhaps by fetal antigen.
D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity; D000951:Antigens, Neoplasm; D002286:Carcinoma, Ehrlich Tumor / Q000139:chemically induced; D002462:Cell Membrane / Q000276:immunology; D007111:Immunity, Cellular; D008213:Lymphocyte Activation / Q000187:drug effects; D008748:Methylcholanthrene; D051379:Mice; D008815:Mice, Inbred Strains; D009363:Neoplasm Proteins / Q000276:immunology; D009374:Neoplasms, Experimental / Q000276:immunology*; D051381:Rats; D011919:Rats, Inbred Strains
D000951:Antigens, Neoplasm; D009363:Neoplasm Proteins; D008748:Methylcholanthrene
Contrôle do crescimento de tumor experimental. I. Proteção do hospedeiro por inoculação prévia da fração de membrana plasmática de célula tumoral.