[Pharmacological properties of water-soluble levorin].
The results of the study of the pharmacological properties of the preparation of 5 per cent levorin solution in 40 per cent sodium salicylate solution are presented. The toxicity of levorin contained in the preparation was studied in the acute experiment on its intraperitoneal administration to mice. It did not differ from that of sodium levorin. In concentration of 5000 units/ml with respect to levorin the preparation did not change the motion speed of the ciliated epithelium cilia of the frog esophagus when used in the form of aerosol. Innocuousness of the preparation used repeatedly for inhalation in the form of aerosol was studied. The preparation was innocuous in the doses 12 and 24 times higher than the therapeutic ones. When applied locally on the skin and the eye conjunctiva for 16-20 days the preparation in the respective pharmaceutical forms was innocuous. Absorption and distribution of the water-soluble levorin in mice treated with the drug intraperitoneally or inhalationally was studied. It was found that levorin contained in the preparation circulated in the blood in bacteriostatic concentrations after its intraperitoneal administration for 8 hours. When used as inhalation in the form of aerosol levorin was detected in the lungs and urine and circulated in concentrations exceeding the bacteriostatic ones for 12 hours.
D000042:Absorption; D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D001001:Anura; D001769:Blood / Q000187:drug effects; D002174:Candicidin / Q000494:pharmacology* / Q000633:toxicity; D002923:Cilia / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D006168:Guinea Pigs; D007928:Lethal Dose 50; D051379:Mice; D051381:Rats; D012869:Skin Absorption / Q000187:drug effects; D012980:Sodium Salicylate / Q000633:toxicity; D012995:Solubility; D013997:Time Factors
D000935:Antifungal Agents; D004338:Drug Combinations; D002174:Candicidin; D012980:Sodium Salicylate
Farmakologicheskie svoĭstva vodorastvorimogo levorina.