title: Effects of catecholamine manipulations on three different self-stimulation behaviors.
abstract: Rats with self-stimulation electrodes in the medial part of lateral hypothalamus (LH) or in the lateral part of LH were trained to bar press, to run in a continuous, square-shaped runway, and to move their tails from side to side while otherwise restrained, all using LH stimulation on an FI 2 sec schedule as the reinforcement. At low doses of pimozide (a dopaminergic blocker) or of FLA-57 (a dopamine beta-hydroxylase inhibitor) different effects on rates of responding were observed on each of the 3 tasks at the 2 electrode placements, indicating that the rate reductions were not the results of specific performance effects of the drugs. The patterns of rate changes suggested that the effects of LH stimulation on behavior in the runway were primarily, but not exclusively mediated by a dopaminergic system; that the effects of LH stimulation on tail movement were primarily, but not exclusively mediated by a noradrenergic system; and that the effect of LH stimulation on bar pressing was mediated by both, or either of these substrates. These results suggest that the reinforcement of behavior by LH stimulation is flexibly mediated by at least 2 different neural systems.
mesh_terms: D000818:Animals; D004299:Dopamine beta-Hydroxylase / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D007031:Hypothalamus; D008297:Male; D010868:Pimozide / Q000494:pharmacology*; D051381:Rats; D012054:Reinforcement, Psychology; D012653:Self Stimulation / Q000187:drug effects*
chemical_list: D010868:Pimozide; D004299:Dopamine beta-Hydroxylase