[B virus chronic hepatitis in the haemodialysed uraemic patient. Correlation between hepatic lesions and the presence of antigen e in 12 patients (author's transl)].
Twelve patients on haemodialysis for 6 months to 3 years contracted AgHBs positive hepatitis, 9 being also Ag e positive. They continued to carry the same antigens. Histological surveillance was begun from the 6th month of the disease onwards, with 2 to 4 repeated biopsies in 1,5 to 3,5 years in 9 patients, the last 3 having only one biopsy between the 8th and the 15th month. In 6 patients, the first biopsy revealed chronic persistent hepatitis (CPH) and in other 6 (5 male and 1 female) chronic aggressive hepatitis (CAH). Subsequent biopsies revealed cirrhosis in a patient treated with alphamethyldopa (Ag e +), the absence of any changes in 7 other patients (4 CPH including 3 Ag e +  and 3 CAH including 2 Ag e +), and an improvement in the last. Long term surveillance of hepatitis B by repeated biopsies in haemodialysed patients reveals that histological lesions are stable at 2 years, that certain drugs may have an aggravating role and that Ag e has no prognostic value.
D001707:Biopsy, Needle; D005260:Female; D005500:Follow-Up Studies; D006509:Hepatitis B / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D006511:Hepatitis B Antigens / Q000032:analysis; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006801:Humans; D008297:Male; D006435:Renal Dialysis / Q000009:adverse effects*; D014511:Uremia / Q000628:therapy*
D006511:Hepatitis B Antigens; D006514:Hepatitis B Surface Antigens
Hépatite chronique à virus B chez l'urémique hémodialysé. Corrélation entre les lésions hépatiques et la présence de l'antigène e, chez 12 malades.