[Autoradiographic study of stimulation of RNA synthesis in fibroblasts].
The rate of uridine-5 3H incorporation into the skin-muscle wound fibroblasts of control and experimental animals, and also into the fibroblasts of flocculent connective tissue of intact animals was studied. The character of incorporation and distribution of the isotope in the nuclei and cytoplasm in the flocculent connective tissue fibroblasts differed in intact mice from those in the wound fibroblasts only by intensity. Potassium orotate RNA synthesis stimulation in the fibroblast nuclei closely correlated with the increased rate and intensity of the labeled RNA passage from the cell nuclei to the sites of collagen synthesis.
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D005347:Fibroblasts / Q000378:metabolism*; D006097:Granulation Tissue / Q000166:cytology; D051379:Mice; D009132:Muscles / Q000293:injuries; D009963:Orotic Acid / Q000494:pharmacology*; D012313:RNA / Q000096:biosynthesis*; D012867:Skin / Q000293:injuries; D013268:Stimulation, Chemical; D014529:Uridine / Q000378:metabolism; D014945:Wound Healing / Q000187:drug effects
D009963:Orotic Acid; D012313:RNA; D014529:Uridine
Avtoradiograficheskoe issledovanie stimuliatsii sinteza RNK v fibroblastakh.