[The antigenicity of various new chromatographically purified depot insulin preparations].
Four groups of adult diabetics who had never received insulin before were treated for 10--12 months with the following insulin preparations: 1. Insulin Lente, purified by conventional methods; 2. Insulin Lente, purified by gel-filtration; 3. Insulin Lente Monocomponent (MC); 4. Insulin Monotard. Insulin antibodies were measured in these four groups at regular intervals and compared. MC Lente is significantly less antigenic than conventional Lente insulin, but Monotard, a pure pork insulin preparation, is even less antigenic than MC Lente (all 3 Lente preparations contain 70% ox insulin). The average insulin requirement in the Monotard group is significantly lower than in the conventional Lente group.
D000328:Adult; D000941:Antigens / Q000302:isolation & purification; D003920:Diabetes Mellitus / Q000188:drug therapy*; D006801:Humans; D007328:Insulin / Q000276:immunology* / Q000627:therapeutic use; D007330:Insulin Antibodies / Q000032:analysis; D049528:Insulin, Long-Acting / Q000302:isolation & purification; D011384:Proinsulin / Q000302:isolation & purification
D000941:Antigens; D007328:Insulin; D007330:Insulin Antibodies; D049528:Insulin, Long-Acting; D011384:Proinsulin
Die Antigenität einiger neuer, chromatographisch gereinigter Depot-Insulin-Präparate.