title: Aminoalkane sulfonic acids. Synthesis of some mitodepressive heterocyclic aminoalkane sulfonic acids.
abstract: The reaction of 2-aminopyrimidine with benzaldehyde in all applied methods yielded instead of benzal-2-aminopyrimidine (1) regardless of the procedure used, N.N'-benzilidene-bis-2-aminopyrimidine (2). The expected product benzal-2-aminopyrimidine has not been formed in any case. For this reason the synthesis of aminoalkanesulfonic acids has not been carried out by the use of Schiff bases as starting material. Reaction of aldehyde bisulfite adducts and corresponding amine, was used instead. In the syntheses where 2-aminopyridine was used as the amine part, the corresponding aminoalkanesulfonic acids were formed (3--5), while 2-aminopyrimidine under the same condition gave several reaction products (6--10). All compounds obtained were tested for their growth inhibitory activity on the seeds of cress (Lepidium sativum L.).
mesh_terms: D000631:Aminopyridines; D055598:Chemical Phenomena; D002621:Chemistry; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D063245:Plant Development; D010944:Plants / Q000187:drug effects; D011743:Pyrimidines; D013451:Sulfonic Acids / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000631:Aminopyridines; D006571:Heterocyclic Compounds; D011743:Pyrimidines; D013451:Sulfonic Acids