[Simultaneous comparative renal clearances and renal iodo (I125)-hippurate in man (author's transl)].
In 111 Patients with a wide range of renal function (normal to advanced renal failure) the renal clearances of Na-paraaminohippurate (CPAH) and of Na-orthojodohippurate--J125(COJ(J125(H) have been simultaneously determined under standardized clearance conditions. We found a significant correlation between the 2 parameters, defined by the equation CPAH = 1.11.COJ(J125)H. The scatter of the single observations however is considerable and hence the +/- 2Sy range is very large. The difference between the 2 clearances is not die to a competition at the same tubular carrier, since adding inactive carrier of OJH does not improve the ratio of the 2 clearances: CPAH = 1.13.COJ(J125)H. Rather the renal extraction of OJ(J125)H(EOJ(J125)H is considerably lower (74% than EPAH (90%). Our datas suggest that OJ(J125)H is not a suitable indicator to replace PAH for measurements of real renal plasma flow.
D006801:Humans; D007457:Iodine Radioisotopes; D007465:Iodohippuric Acid / Q000378:metabolism; D007668:Kidney / Q000378:metabolism*; D007674:Kidney Diseases / Q000378:metabolism; D013997:Time Factors
D007457:Iodine Radioisotopes; D007465:Iodohippuric Acid
Vergleichende Untersuchungen der simultanen renalen Clearances und der renalen Extraktionen von Natrium-Paraaminohippurat (PAH) und Natrium-Orthojodohippurat OJ(J125)H.