title: [Influence of thyroid state on noise-induced cochlea damage (author's transl)].
abstract: Guinea pigs were exposed to pure tone noise (2.7 kHz, 130 dB, 1 h) and cochlear microphonic potentials were measured after 5 days. It is possible, to modify the resulting damage by experimentally altering the rate of metabolism by regulating the function of the thyroid gland. (table: see text) A hypofunction of the thyroid gland during sound exposure lessens, an over-function aggravates the damage. This effect possibly results from the influence on the metabolism exerted by the adenylic system. This conclusion leads to new viewpoints concerning prophylaxis, therapy and metaphylaxis in cases of noise deafness.
mesh_terms: D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D004734:Energy Metabolism; D006168:Guinea Pigs; D006317:Hearing Loss, Noise-Induced / Q000209:etiology* / Q000517:prevention & control; D006980:Hyperthyroidism / Q000503:physiopathology; D007037:Hypothyroidism / Q000150:complications; D009925:Organ of Corti / Q000378:metabolism; D013961:Thyroid Gland / Q000378:metabolism*; D013974:Thyroxine / Q000378:metabolism
chemical_list: D000262:Adenylyl Cyclases; D013974:Thyroxine
vernacular_title: Der Einfluss der Schilddrüsenfunktion aud den lärmbedingten Innenohrschaden.