title: Effect of single and repeated carbon monoxide intoxications on urinary catecholamine excretion in rats.
abstract: In preliminary experiments it had been shown that the total catecholamines in the urine of rats collected during 5 hrs after stimulation of diuresis with 50 ml tap water/kg body weight per os were not changed significantly following a 3-week training in individual metabolic cages, a short pressing of the animals against the laboratory table, a single i. p. injection of 2 ml sodium chloride solution (145 mmol/l)/kg body weight, or a single s. c. injection of 40 ml air per animal. The excretion was increased after puncture of the retroorbital plexus and after exposure to cold (+5 degrees C) during the 5 hrs. Carbon monoxide poisoning produces an inhibition of diuresis. Therefore, to study the effect of carbon monoxide intoxications on urinary catecholamine excretion we administered 25 ml tap water/kg additionally. Single s. c. injection of 7.2 mmol CO/kg body weight (53% COHb) induced a significant increase of urinary catecholamines. Due to repeated injections of the same CO dose a gradual disappearance of this effect was seen. After 4 weeks the differences to controls are negligible.
mesh_terms: D000818:Animals; D002249:Carbon Monoxide Poisoning / Q000652:urine*; D002395:Catecholamines / Q000652:urine*; D007700:Kinetics; D008297:Male; D051381:Rats; D013312:Stress, Physiological / Q000652:urine
chemical_list: D002395:Catecholamines