Effect of non-steroidal anti-inflammatory drugs of Moloney sarcoma virus inoculated mice.
Chronic administration of phenylbutazone, flufenamic acid and a new, potent non-steroidal anti-inflammatory agent ITF (3-methyl-5-benzoyl-amino-isothiazole-4-carboxy-p-ethoxyphenylamine) to BALB/c mice inoculated with a Moloney sarcoma virus resulted in a stimulation of tumor growth and increased severity of disease. This treatment, however, had no effect on the spontaneous regression of tumors. Indomethacin in a dose of 5.0 or 2.5 mg per kg suppressed the MSV-induced tumor growth, but this effect was apparently connected with the high toxicity of this drug for mice.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D007213:Indomethacin / Q000627:therapeutic use; D007942:Leukemia, Experimental / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008979:Moloney murine leukemia virus; D009365:Neoplasm Regression, Spontaneous
D000893:Anti-Inflammatory Agents; D007213:Indomethacin