title: A two-dose schedule for immunization of infants using a more concentrated DPT-vaccine.
abstract: In a controlled field-trial in infants in the Philippines, a two-dose schedule with an interval of 6 months between injections using a concentrated adsorbed DPT-vaccine was evaluated. The serologic response against the three components in the vaccine was satisfactory, whereas the side-effects in the concentrated vaccine group did not differ from those observed in a control DPT group. After two injections, the coverage percentage with DPT-vaccine was shown to be higher than 70%. Two implications of the introduction of the two-dose DPT-immunization schedule are discussed, i.e. (a) the possibility of using it as the nucleus of a complete schedule including immunization against poliomyelitis, BCG, smallpox and measles, and (b) the consequences which the interval of 6 months might have on the epidemiological spread of B. pertussis infections.
mesh_terms: D000367:Age Factors; D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000276:immunology / Q000494:pharmacology*; D004165:Diphtheria / Q000276:immunology / Q000517:prevention & control*; D004168:Diphtheria Toxoid / Q000276:immunology / Q000494:pharmacology; D006801:Humans; D007114:Immunization; D007115:Immunization Schedule; D007223:Infant; D010567:Pertussis Vaccine / Q000276:immunology / Q000494:pharmacology; D010679:Philippines; D013742:Tetanus / Q000276:immunology / Q000517:prevention & control*; D013745:Tetanus Toxoid / Q000276:immunology / Q000494:pharmacology; D014917:Whooping Cough / Q000276:immunology / Q000517:prevention & control*
chemical_list: D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D004168:Diphtheria Toxoid; D010567:Pertussis Vaccine; D013745:Tetanus Toxoid