title: The action of conformationally restricted analogues of GABA on Limulus and Helix central neurones.
abstract: Intracellular recordings have been made from GABA sensitive neurones in the central nervous system of Limulus and Helix. The following conformationally restricted analogues of GABA all possessed GABA-like activity on Limulus neurones and Helix excitatory GABA receptors: muscimol, thiomuscimol, THIP, isoguvacine and piperidine-4- carboxylic acid. It is suggested that GABA interacts with these receptors in a partially extended and almost planar conformation.
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002490:Central Nervous System / Q000187:drug effects*; D006372:Helix, Snails / Q000187:drug effects*; D006737:Horseshoe Crabs / Q000187:drug effects*; D066298:In Vitro Techniques; D008968:Molecular Conformation; D009474:Neurons / Q000187:drug effects*; D013329:Structure-Activity Relationship; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D005680:gamma-Aminobutyric Acid