[Comparison of the effect of catecholamines on the blood flow in the coronary and in the femoral circulation].
The effect of adrenaline and noradrenalin on the coronary circulation was studied in narcotized dogs. In 14 dogs every 20 seconds the venous blood from coronary sinus was examined. In a second series of animals the blood flow in the coronary artery and in the femoral artery was recorded continuously after intraarterial, resp. intravenous injection of catecholamines. In some experiments a constant perfusion pressure in coronary and femoral systems was maintained by help of a stabilizing device. The results of these experiments unequivocally proved that application of catecholamine was always followed by dilatation of the myocardiac and constriction of femoral vascular system. In no case catecholamines caused initial vasoconstriction of coronary vessels. The reasons for that paradoxical efficacy are discussed.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002395:Catecholamines / Q000494:pharmacology*; D003331:Coronary Vessels; D004285:Dogs; D004837:Epinephrine / Q000494:pharmacology; D005263:Femoral Artery; D009638:Norepinephrine / Q000494:pharmacology; D012039:Regional Blood Flow / Q000187:drug effects*; D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents
D002395:Catecholamines; D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents; D009638:Norepinephrine; D004837:Epinephrine
Der Vergleich der Wirkung von Katecholaminen auf den Blutfluss im koronaren und femoralen Gefässgebiet.