[Pyoderma gangrenosum associated with seronegative polyarthritis. Report of a case. Review of the literature (author's transl)].
Pyoderma gangrenosum developed in a 45-year-old caucasian woman who had an 18 year past history of seronegative polyarthritis without any visceral or haematologic associated abnormalities. A literature review revealed only 12 reported cases. Extensive laboratory evaluation failed to detect alterations of the immune functions. The presence of a vasculitis with C3 deposits suggested that levamisole may have played a role in eliciting the lesion. Clofazimine, administered for a period of one month, was a relative failure.
D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000276:immunology; D002991:Clofazimine / Q000627:therapeutic use; D005260:Female; D005734:Gangrene; D006801:Humans; D007978:Levamisole / Q000009:adverse effects; D008875:Middle Aged; D011711:Pyoderma / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D014657:Vasculitis / Q000139:chemically induced / Q000150:complications
D007978:Levamisole; D002991:Clofazimine
Pyoderma gangrenosum associé a une polyarthrite séro-négative. A propos d'un cas. Revue de la littérature.