title: Effect of subacute manganese feeding on serotonin metabolism in the rat.
abstract: To clarify the effect of subacute manganese feeding on serotonin and mineral metabolism, Wistar rats were separated into two groups and fed two different diets, one a normal diet and the another a manganese-supplemented diet. After three weeks on these dietary regimens, the rats on the manganese-supplemented diet manifested the following abnormalities: blood pressure was decreased; brain serotonin was decreased; L-aromatic amino acid decarboxylase activity in brain was decreased. Manganese levels in heart, lung, and kidney increased, whereas sodium, potassium, magnesium and calcium levels in the brainstem decreased.
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000378:metabolism; D002262:Carboxy-Lyases / Q000378:metabolism; D004573:Electrolytes / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D008345:Manganese / Q000378:metabolism / Q000494:pharmacology*; D008995:Monoamine Oxidase / Q000378:metabolism; D051381:Rats; D012701:Serotonin / Q000097:blood / Q000378:metabolism*
chemical_list: D004573:Electrolytes; D012701:Serotonin; D008345:Manganese; D008995:Monoamine Oxidase; D002262:Carboxy-Lyases