Effects of prostaglandins on vesicourethral smooth muscle of rabbit. Therapeutic implications.
The effects of PGF 2-alpha and PGE2 on the vesicourethral smooth muscle of the rabbit were studied in vitro. PGF2-alpha had potent contractile effects on the bladder body and comparatively less in the bladder base and the proximal urethra. PGE2 contractile effects were two times greater than PGF 2-alpha on the bladder body but minimal or absent on the base and the urethra. The effects of PGF2-alpha and PGE2 seem to be mediated through a prostaglandin receptor as indicated by competitive antagonism of both prostaglandins by N-0164, a synthetic phenyl phosphonate. It also appears that the effects of PGF2-alpha PGE2 may not be mediated through muscarinic, adrenergic, nicotinic, or histaminic receptors or direct smooth-muscle action. The therapeutic implications of PGE2 in the  patients with problems of bladder emptying are discussed.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001464:Barium / Q000494:pharmacology; D005260:Female; D006632:Histamine / Q000494:pharmacology; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D063065:Organophosphonates; D009943:Organophosphorus Compounds / Q000494:pharmacology; D011448:Prostaglandin Antagonists / Q000494:pharmacology; D011458:Prostaglandins E / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D011460:Prostaglandins F / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D011817:Rabbits; D011982:Receptors, Prostaglandin / Q000378:metabolism; D014521:Urethra / Q000187:drug effects*; D001743:Urinary Bladder / Q000187:drug effects*; D014555:Urination Disorders / Q000188:drug therapy
D063065:Organophosphonates; D009943:Organophosphorus Compounds; D011448:Prostaglandin Antagonists; D011458:Prostaglandins E; D011460:Prostaglandins F; D011982:Receptors, Prostaglandin; D001464:Barium; C012641:N 0164; D006632:Histamine; D000109:Acetylcholine; D009638:Norepinephrine; D007213:Indomethacin