title: Congenital ataxia and tremor with cerebellar hypoplasia in piglets borne by sows treated with Neguvon vet. (metrifonate, trichlorfon) during pregnancy.
abstract: In 1976--77 The State Veterinary Serum Laboratory received new-born pigs which had shown nervous disorders immediately after birth. In all the cases the sows had been treated with Nevugon vet. (metrifonate, trichlorfon) during pregnancy. In the majority of the affected litters the morbidity and lethality were 100 per cent. Analysis of the breeding data from some of the herds suggested that the period during which the fetuses are sensitive is rather narrow, i.e., approximately from day 45 to day 63. The disease was reproduced experimentally and it was concluded that oral treatment of pregnant sows with Neguvon vet. about the middle of the gestation period can result in severe nervous disorders in the piglets. Clinically the disease is characterized by ataxia and tremor, and corresponding to that there is a pronounced hypoplasia of the cerebellum and also a reduction in the size of the spinal cord.
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000662:veterinary*; D000818:Animals; D000831:Animals, Newborn; D001259:Ataxia / Q000139:chemically induced / Q000151:congenital / Q000662:veterinary*; D002531:Cerebellum / Q000002:abnormalities* / Q000473:pathology; D002802:Cholinesterases / Q000097:blood; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D005865:Gestational Age; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D013552:Swine; D013553:Swine Diseases / Q000139:chemically induced / Q000151:congenital* / Q000473:pathology; D014202:Tremor / Q000139:chemically induced / Q000151:congenital / Q000662:veterinary*; D014236:Trichlorfon / Q000009:adverse effects*
chemical_list: D014236:Trichlorfon; D002802:Cholinesterases