title: [Non-steroidal anti-inflammatory agents. VI. Optically active 3-(4-biphenylyl)-3-oxybutyric, valerianic, caproic and isocaproic acids].
abstract: The synthesis of the (+/-) 3-(4-biphenylyl)-3-hydroxybutanoic, pentanoic, hexanoic and isohexanoic acids, and their resolution in to enantiomers are described. The latter were submitted to preliminary assay for antiinflammatory activity: interesting results were obtained above all for the isohexanoic acid derivative.
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis*; D002208:Caproates / Q000138:chemical synthesis* / Q000494:pharmacology; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000503:physiopathology; D006885:Hydroxybutyrates / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D010421:Pentanoic Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D013237:Stereoisomerism; D014631:Valerates / Q000138:chemical synthesis*
chemical_list: D000893:Anti-Inflammatory Agents; D002208:Caproates; D006885:Hydroxybutyrates; D010421:Pentanoic Acids; D014631:Valerates; D002351:Carrageenan
vernacular_title: Antiinfiammatori non steroidei. Nota VI - Acidi 3-(4-bifenilil)-3-ossibutirrico, valerianico, capronico e isocapronico otticamente attivi.