title: Synthesis and pharmacological properties of 1,3 and 5-substituted 2-pyrrolidinones.
abstract: We described synthesis of 1-aryl-3 and 5-substituted 2-pyrrolidinones (2a--5a and 3b--4b). Pharmacological studies revealed that compounds 3b, 4a and 4b have analgetic and antiinflammatory properties. None of the compounds posesses neuroleptic or anticonvulsant properties.
mesh_terms: D000700:Analgesics; D000818:Animals; D000893:Anti-Inflammatory Agents; D055598:Chemical Phenomena; D002621:Chemistry; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D011760:Pyrrolidinones / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D011930:Reaction Time / Q000187:drug effects
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D011760:Pyrrolidinones