The diagnosis and treatment of sickled erythrocytes in human hyphemas.
Four patients with sickle cell hemoglobinopathies (one SC; three AS) and hyphemas were found to have more erythrocytes sickled in their anterior chambers than in their circulating venous blood. Intraocular pressure was severely elevated, despite relatively small amounts of intracameral blood. Systemic hypotensive agents were not always successful in reducing IOP, and in patients with sickle cell hemoglobinopathy, are probably contraindicated in high or repeated dose regimens. Moderate elevation of IOP in sickle cell hemoglobinopathy patients may produce rapid deterioration of visual function, perhaps because of a greater effect on vascular perfusion in the CRA and optic nerve. Early anterior chamber paracentesis may be the best treatment for this type of hyphema-induced secondary glaucoma.
D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000097:blood* / Q000150:complications; D000867:Anterior Chamber / Q000601:surgery; D001707:Biopsy, Needle; D002648:Child; D004913:Erythrocytes, Abnormal; D005260:Female; D005901:Glaucoma / Q000097:blood* / Q000209:etiology / Q000601:surgery; D006801:Humans; D006988:Hyphema / Q000097:blood* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D012805:Sickle Cell Trait / Q000150:complications; D014680:Veins