title: Regulation of interstitial cell differentiation in Hydra attenuata. V. Inability of regenerating head to support nematocyte differentiation.
abstract: Nematocyte differentiation was examined during head regeneration in Hydra attenuata. Nematocyte precursors were found to decrease in head-regenerating tissue. This decrease could not be attributed to decreased stem cell commitment or to altered cellular kinetics. The nematocyte precursors could be 'rescued' by regrafting a head onto the initially regenerating tissue only prior to the time at which head determination occurred. These results suggest that concurrent with head determination an irreversible change occurs in the tissue environment, resulting in decreased survival of cells committed to nematocyte differentiation.
mesh_terms: D000818:Animals; D002452:Cell Count; D002454:Cell Differentiation; D006829:Hydra / Q000166:cytology* / Q000502:physiology; D008938:Mitosis; D009024:Morphogenesis; D012038:Regeneration; D013997:Time Factors