Further studies on rabies postexposure prophylaxis in mice: a comparison of vaccine with interferon and vaccine.
Mice were inoculated in the left hind footpad with street rabies virus, and 24 h later various types of rabies vaccine were administered intramuscularly in the right leg. The vaccines alone were ineffective in reducing mortality, but when an interferon inducer, polyriboinosinic acid-polyribocytidylic acid complexed to poly-L-lysine (polyICLC), was given along with the vaccines, a marked reduction resulted. The polyICLC-vaccine combination was effective even when it was injected 5 days after infection, suggesting that effective postexposure treatment in man might be successful when given at a comparable late time.
D000818:Animals; D004359:Drug Therapy, Combination; D005260:Female; D007369:Interferon Inducers / Q000627:therapeutic use; D007372:Interferons / Q000627:therapeutic use*; D051379:Mice; D011818:Rabies / Q000517:prevention & control*; D011819:Rabies Vaccines
D007369:Interferon Inducers; D011819:Rabies Vaccines; D007372:Interferons