title: [Morphogenesis of Mikulicz's cells (electron-optic study)].
abstract: In a female aged 83 who had been living in Prague for years, a bioptic diagnosis of rhinoscleroma was made. The disease responded well to Septrin treatment. Electron microscopical examination confirmed the histiocytic origin of Mikulicz cells, but cast doubt upon the belief that the large phagocytic cysts in such cells developed by confluence of smaller vacuoles. The examination revealed that the large cystic formations only contained Klebsiellae and a dense finely granular material identical with that of the bacterial capsiles. The small vacuoles found in the vicinity of the large ones never contained bacteria and their contents was either coarsely granular of finely filamentous. Therefore it rather corresponded to degradation products of the original content of the larger phagocytic cysts. The final picture of the Mikulicz cell are macrophages with only small light rounded vacuoles containing mucoid but no Klebsiellae.
mesh_terms: D000368:Aged; D005260:Female; D005487:Foam Cells / Q000166:cytology* / Q000648:ultrastructure; D006801:Humans; D008046:Lip; D008264:Macrophages / Q000166:cytology* / Q000648:ultrastructure; D009024:Morphogenesis; D012226:Rhinoscleroma / Q000188:drug therapy / Q000473:pathology*
vernacular_title: Morfogeneze Mikuliczových bunĕk (elektronoptická studie).