Prolonged action of drugs in rats with flavonoid-deficiency.
In flavonoid-deficient Wistar-rats, the action of caffeine, harmine, hexobarbital, morphine and pentobarbital is enhanced. In contrast, the thiopental sleeping time is shortened. These observations may indicate impaired drug metabolism as a consequence of the flavonoid-deficiency state.
D000818:Animals; D001463:Barbiturates / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D002110:Caffeine / Q000494:pharmacology; D004032:Diet; D005419:Flavonoids / Q000172:deficiency*; D006247:Harmine / Q000494:pharmacology; D008297:Male; D009020:Morphine / Q000494:pharmacology; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D051381:Rats; D013997:Time Factors
D001463:Barbiturates; D005419:Flavonoids; D004364:Pharmaceutical Preparations; D002110:Caffeine; D006247:Harmine; D009020:Morphine