title: Monitoring and risk assessment by means of alkyl groups in hemoglobin in persons occupationally exposed to ethylene oxide.
abstract: In persons occupationally exposed to ethylene oxide, i.e. under the conditions described by Dunkelberg and Hartmetz (1977), the degree of alkylation in histidine of hemoglobin was determined. Quantitative determination of N-3-(2-hydroxyethyl)histidine by mass fragmentography and by ion-exchange amino-acid analysis gave consistent results. Data are in agreement with the fast elimination from tissues (lambda = 4.6 hr-1, i.e. biological half-life about 9 min) found in the mouse. At the respiration rate of light work, and exposure dose of 1 ppm/hr results in a tissue dose that is estimated to involve a risk amounting to 1.101 mrad-equivalents of stochastic effects with a genetic mechanism.
mesh_terms: D000328:Adult; D000478:Alkylation; D000596:Amino Acids / Q000097:blood; D002274:Carcinogens, Environmental; D055598:Chemical Phenomena; D002621:Chemistry; D005027:Ethylene Oxide / Q000009:adverse effects*; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006454:Hemoglobins / Q000378:metabolism*; D006639:Histidine / Q000097:blood; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000097:blood* / Q000139:chemically induced; D012306:Risk
chemical_list: D000596:Amino Acids; D002274:Carcinogens, Environmental; D006454:Hemoglobins; D006639:Histidine; D005027:Ethylene Oxide