[Effects of uncouplers on the phospholipid composition of mitochondria].
A decrease in the level of lysocardiolipin and lysophosphatidylethanolamine in mitochondria induced by chlorophenacyl and 2,4-dinitrophenol was demonstrated. The effects of the uncouplers were especially well-pronounced under conditions of mitochondrial swelling. It was found that the phospholipase inhibitor nupercain completely reverses the effects. The data obtained suggest that 2,4-dinitrophenol and alkylating compounds increase the phospholipase activity of mitochondria under given experimental conditions.
D000818:Animals; D004140:Dinitrophenols / Q000494:pharmacology*; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D008933:Mitochondrial Swelling / Q000187:drug effects; D010743:Phospholipids / Q000378:metabolism*; D014475:Uncoupling Agents / Q000494:pharmacology*
D004140:Dinitrophenols; D010743:Phospholipids; D014475:Uncoupling Agents
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