Study of the comparative effectiveness of Dulcolax, Laxadine, Dorbanex, Normacen and Senokot laxatives in the bowel preparation of patients for radiological examinations.
The effectiveness of five laxatives - Dulcolax, Normacen, Laxadine, Dorbanex and Senokot in the bowel preparation of adult patients for radiological examinations has been compared. The value of using suppositories in addition to the tablets in those preparations that have tablet and suppository forms has also been assessed. The use of Dulcolax tablets plus suppository was most effective. Dulcolax, especially its suppository, was however very expensive and more frequently attended by side effects when compared with the other preparations. Normacen tablet was the second most effective and it is cheap and quite free of side effects. It is therefore given the position of first choice. Laxadine tablet plus its suppository was third best. It is cheap and free of side effects. Dorbanex was fourth best but it is rather expensive. Senokot tablet was the least effective but it is cheap and relatively free from side effects. In those laxatives with tablet and suppository forms, the use of both tablet and suppository is much more effective than the use of the tablet form alone.
D000005:Abdomen / Q000187:drug effects; D000284:Administration, Oral; D000880:Anthraquinones / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D001726:Bisacodyl / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D002400:Cathartics / Q000494:pharmacology*; D004338:Drug Combinations; D006027:Glycosides / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D006801:Humans; D007422:Intestines / Q000000981:diagnostic imaging* / Q000187:drug effects; D010114:Oxyphenisatin Acetate / Q000009:adverse effects / Q000031:analogs & derivatives / Q000494:pharmacology; D010146:Pain / Q000139:chemically induced; D011060:Poloxalene / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D011859:Radiography; D012676:Senna Extract / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology
D000880:Anthraquinones; D002400:Cathartics; D004338:Drug Combinations; D006027:Glycosides; C020390:laxadine; D001726:Bisacodyl; D012676:Senna Extract; D011060:Poloxalene; D010114:Oxyphenisatin Acetate