Total exchangeable potassium in response to amiloride.
The use of amiloride is described in twenty-four hypertensive patients who became hypokalaemic as a result of thiazide diuretic therapy in spite of oral potassium supplments. Amiloride caused a significant rise in exchangeable potassium, exchangeable potassium/kg body weight, and plasma potassium, together with a significant fall in plasma total carbon dioxide, body weight, systolic and diastolic blood pressures. These results suggest that amiloride has a useful role in this type of patient.
D000584:Amiloride / Q000627:therapeutic use*; D001835:Body Weight; D002245:Carbon Dioxide / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000378:metabolism*; D007008:Hypokalemia / Q000188:drug therapy*; D011188:Potassium / Q000378:metabolism*; D011719:Pyrazines / Q000627:therapeutic use*; D013997:Time Factors
D011719:Pyrazines; D002245:Carbon Dioxide; D000584:Amiloride; D011188:Potassium