Is there a blood-brain relationship for saturated fatty acids during development?
Transport of subcutaneously injected [1-14C]-stearic acid through the blood-brain barrier is compared with endogenous biosynthesis (within the brain) during postnatal brain development in mice. The uptake is very important during glial cell multiplication and myelination; endogenous microsomal synthesis is most active during myelination, soluble de novo mechanism is prominent during cell multiplication (mitochondrial systems are not directly related to these events). A parallel is drawn between myelin fatty acids, microsomal synthesis and uptake from the blood.
D000818:Animals; D001812:Blood-Brain Barrier; D001921:Brain / Q000166:cytology / Q000254:growth & development / Q000378:metabolism*; D002455:Cell Division; D005227:Fatty Acids / Q000096:biosynthesis / Q000378:metabolism*; D050356:Lipid Metabolism; D051379:Mice; D009186:Myelin Sheath / Q000378:metabolism; D013229:Stearic Acids / Q000378:metabolism
D005227:Fatty Acids; D013229:Stearic Acids