Effect of phenylhydrazine on delta-aminolevulinic acid dehydratase in red blood cells.
Delta-aminolevulinic acid dehydratase activity was measured in the blood of rats poisoned by successive injections of phenylhydrazine (1 ml, 35 mmol). After 5 days of successive injections, more than 90% of the circulating blood cells consisted of reticulocytes and the enzyme activity also increased successively and reached a maximum corresponding to the number of reticulocytes. Thus delta-aminolevulinic acid dehydratase activity measured in the peripheral blood is mainly due to the percentage of circulating reticulocytes.
D000818:Animals; D004906:Erythrocyte Count; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology*; D005260:Female; D010659:Phenylhydrazines / Q000494:pharmacology*; D000623:Porphobilinogen Synthase / Q000097:blood*; D051381:Rats; D012156:Reticulocytes / Q000187:drug effects; D013997:Time Factors
D010659:Phenylhydrazines; D000623:Porphobilinogen Synthase