title: Kindling effect in the reptilian brain: motor and electrographic manifestations.
abstract: The extension of the kindling effect to the reptilian brain is reported with two experimental groups of lizards Lacerta galloti. The first group received daily stimulation in the telencephalic cortex at a current level sufficient to produce motor responses. These motor responses occurred only when the stimulus was applied, and disappeared when it was terminated. However, the threshold for evoking these motor responses decreased in 20 days of stimulation, and the responses evolved to stimulus-bound convulsions. In the second group, the stimulus was too low to produce motor responses, but it developed afterdischarges and spontaneous recurrent electrographic seizures that increased their duration with each stimulation. Reptilia are discussed as useful experimental animals for studying the kindling phenomenon.
mesh_terms: D000818:Animals; D001921:Brain / Q000503:physiopathology*; D004558:Electric Stimulation / Q000379:methods*; D005071:Evoked Potentials; D005260:Female; D008116:Lizards; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D009119:Muscle Contraction; D012640:Seizures / Q000503:physiopathology*