[Effect of synthetic motilin on gastric motility (author's transl)].
The effects of the synthetic motilin on the gastric motility were investigated in the dogs with innervated antral pouches in fasting state. The results were as follows: 1) The synthetic motilin stimulated markedly the gastric motor activity in both the contraction pressure and the frequency of the peristalsis. 2) Tetragastrin produced more regular and higher frequent contractions compared with synthetic motilin, but acted to weaker the contraction pressure. 3) In simultaneous administration of the synthetic motilin and the tetragastrin, the synthetic motilin acted more strongly in the contraction pressure, on the other hand tetragastrin in the frequency of the peristalsis. 4) The peristaltic contractions induced by synthetic motilin were completely abolished by the administration of the atropine sulfate. 5) Under medical vagotomy, synthetic motilin was not able to produce any peristatlic contractions, but tetragastrin stimulated strongly the gastric motility.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D004285:Dogs; D005215:Fasting; D005768:Gastrointestinal Hormones / Q000494:pharmacology*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006727:Hormone Antagonists; D006728:Hormones / Q000494:pharmacology*; D009037:Motilin / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D013758:Tetragastrin / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology; D014628:Vagotomy
D005768:Gastrointestinal Hormones; D006727:Hormone Antagonists; D006728:Hormones; D013758:Tetragastrin; D009037:Motilin; D001285:Atropine