[Investigations on the antimicrobial activity of amin-aldehydecondensates. 4. Communication: azomethins of aliphatic aldehydes (author's transl)].
In the scope of our research about the antimicrobial activity of amin-aldehyde-condensates a number of azomethins was synthesized by the condensation of primary aliphatic and aromatic amins with aliphatic aldehydes. Structures and physical constants are listed in table 1 and 2. - The antimicrobial activity of these azomethins is demonstrated by the results of the disk-test (table 3), of the minimal inhibition concentration test (MIC, table 4), and the suspension test (table 5) following the method of the DGHM. - The different water-solubility of the azomethins was equalized by using the standard solution described earlier. - It may be shown that the azomethins have both bacterio- and fungistatic activity which resembles that of the corresponding aldehydes (table 4). The fungistatic activity against Trichophyton mentragrophytes shown by the results of the disk-test is remarkable. - The bactericidal power of the azomethins versus Klebsiella pneumoniae, Pseudomonas aeruginosa and Proteus vulgaris is quiet stronger than that of the corresponding aldehydes.
D000447:Aldehydes; D000588:Amines; D001391:Azo Compounds / Q000494:pharmacology*; D004202:Disinfectants
D000447:Aldehydes; D000588:Amines; D001391:Azo Compounds; D004202:Disinfectants
Untersuchungen zur antimikrobiellen Wirksamkeit von Amin-Aldehydkondensaten 4. Mitteilung: Azomethine aliphatischer Aldehyde.