The in vitro migration inhibition of mononuclear cells in patients with colorectal carcinoma.
The response of peripheral blood mononuclear cells to PHA and PPD in migration inhibition test has been studied in patients with Duke's B-D colorectal carcinoma. It was found the response of patients cells to both stimulants was increased. This enhanced lymphokine release and/or production was closely connected with the tumor load. The implications of these findings to the regulatory mechanisms of the immune response in cancer patients are briefly discussed.
D000328:Adult; D000368:Aged; D002464:Cell Migration Inhibition; D003110:Colonic Neoplasms / Q000276:immunology*; D005770:Gastrointestinal Neoplasms / Q000601:surgery; D006801:Humans; D007111:Immunity, Cellular; D008214:Lymphocytes / Q000276:immunology*; D008222:Lymphokines / Q000096:biosynthesis*; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology*; D009362:Neoplasm Metastasis; D010835:Phytohemagglutinins / Q000494:pharmacology; D012004:Rectal Neoplasms / Q000276:immunology*; D014373:Tuberculin
D008222:Lymphokines; D010835:Phytohemagglutinins; D014373:Tuberculin