[Immunoglobulins (IgG, secretory-IgA) and function of parotid gland in children with cystic fibrosis, with bronchial asthma, and with chronic bronchitis (author's transl)].
The immunoglobulins IgG and IgA (Secretory-IgA) were determined in connection with the parameters of secretion in parotid saliva. Children with cystic fibrosis, with bronchial asthma and with chronic bronchitis were compared. No significant differences were found for the groups of cystic fibrosis, of bronchial asthma, and of chronic bronchitis in comparison to a control group in relation to flow rate and protein content in parotid saliva. The comparison of the groups of diseases showed striking differences only with regard to the output of the gland after stimulation. The output of the gland per minute for IgG was decreased for patients with bronchial asthma as well as for patients with cystic fibrosis. No differences were found for the patients with chronic bronchitis and for the control group. Also the output of the gland for secretory-IgA was decreased after stimulation in the groups of disease: bronchial asthma and cystic fibrosis. The concentration of immunoglobulins in serum no correlation with the concentration of immunoglobulins in saliva neither for IgA nor for IgG. A high content of IgG in serum of patients with cystic fibrosis was observed. The mean values of IgA in serum of patients with chronic bronchitis were found to be significantly decreased.
D000293:Adolescent; D001249:Asthma / Q000503:physiopathology*; D001991:Bronchitis / Q000503:physiopathology*; D002648:Child; D002908:Chronic Disease; D003550:Cystic Fibrosis / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis*; D008297:Male; D010306:Parotid Gland / Q000378:metabolism / Q000503:physiopathology*; D012471:Salivary Proteins and Peptides / Q000032:analysis
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007136:Immunoglobulins; D012471:Salivary Proteins and Peptides
Immunglobuline (IgG, Sekret-IgA) und Funktion der Glandula parotis bei Kindern mit zytischer Fibrose, Asthma bronchiale und chronischer Bronchitis.