title: Indomethacin prevents impaired perfusion of the dogs's brain after global ischemia.
abstract: Compression ischemia of the central nervous system (CNS) in heparinized dogs caused areas of diminished cerebral blood flow measured by 14C-antipyrine autoradiography. Intravenous infusion of indomethacin (1.5 or 4.0 mg/kg) approximately 1 hour before ischemia eliminated the circulatory defects. Prophylactic inhibition of prostaglandin synthetase may promote postischemic perfusion of the CNS by preventing vasoconstriction and by anti-hemostatic effects on blood.
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000503:physiopathology* / Q000517:prevention & control; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004285:Dogs; D007213:Indomethacin / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male
chemical_list: D007213:Indomethacin