Combined chemoimmunotherapy of L5178Y lymphoma.
The antitumoral effect of chemotherapy and immunotherapy with BCG and/or irradiated L5178Y cells has been compared to antitumoral effect of chemotherapy alone. Significantly better results were noted in a transplantable L5178Y lymphoma grafted on DBA/2-J mice treated with methotrexate and BCG than in any other group which was not treated with BCG. The effect of irradiated lymphoma cells was similar to effectivity of methotrexate alone.
D000818:Animals; D000951:Antigens, Neoplasm; D001500:BCG Vaccine / Q000627:therapeutic use*; D005260:Female; D007167:Immunotherapy; D007942:Leukemia, Experimental / Q000188:drug therapy / Q000628:therapy*; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use*; D051379:Mice; D008811:Mice, Inbred DBA; D009368:Neoplasm Transplantation; D014184:Transplantation, Homologous
D000951:Antigens, Neoplasm; D001500:BCG Vaccine; D008727:Methotrexate