GABA-mimetic action of etomidate.
A comparison of antagonism by bicuculline or strychnine of the effects of GABA or etomidate on rat isolated superior cervical ganglia, frog isolated hemisected spinal cords and rat central neurones in vivo indicates that etomidate has GABA-mimetic actions.
D000818:Animals; D001001:Anura; D004305:Dose-Response Relationship, Drug; D005045:Etomidate / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D018691:Excitatory Amino Acid Antagonists; D005725:Ganglia, Autonomic / Q000187:drug effects; D005998:Glycine / Q000494:pharmacology; D007093:Imidazoles / Q000494:pharmacology*; D008564:Membrane Potentials / Q000187:drug effects; D009433:Neural Inhibition; D009474:Neurons / Q000187:drug effects*; D051381:Rats; D013116:Spinal Cord / Q000187:drug effects; D013237:Stereoisomerism; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D018691:Excitatory Amino Acid Antagonists; D007093:Imidazoles; D005680:gamma-Aminobutyric Acid; D005998:Glycine; D005045:Etomidate