[Permeability of the gastric mucosa for carcinogens in taurocholate-induced injury of the mucosa barrier].
The influence of taurocholate-induced damage of the gastric mucosal barrier on transmucosal movement of methyl-N-nitro-N-nitrosoguanidine (MNNG) was investigated on dogs with Heidenhain pouches. We also investigated whether or not MNNG influences the mucosal barrier. The results of 10 experiments revealed no effect of MNNG on the mucosal barrier, but a significant time-related decrease of intraluminal MNNG concentration in the presence of taurocholate.
D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects; D004285:Dogs; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D008769:Methylnitronitrosoguanidine / Q000378:metabolism*; D009994:Osmolar Concentration; D013656:Taurocholic Acid / Q000494:pharmacology*; D013997:Time Factors
D008769:Methylnitronitrosoguanidine; D013656:Taurocholic Acid
Permeabilität der Magenschleimhaut für Carcinogene bei taurocholatinduzierter Schädigung der Mucosabarriere.