[Neo-natal neutropenia induced by anti-NA 2 allo-immunization. Serological and clinical study of 2 cases in a family].
A severe neutropenia in a 2 day old newborn drew attention to anti-HLA and NA 2 antigranulocytic antibodies in the maternal serum. Close supervision from birth of a younger sibling demonstrated a neutropenia on the 5th day of life. Serological investigation showed the anti-NA 2 antibody to be responsible in both cases. A good result with total blood replacement of leucocyte-free blood in the second case would advocate this treatment in cases of severe immunological neutropenia.
D000380:Agranulocytosis / Q000276:immunology*; D000906:Antibodies; D005078:Exchange Transfusion, Whole Blood; D005260:Female; D006098:Granulocytes / Q000276:immunology*; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D007223:Infant; D008297:Male; D009503:Neutropenia / Q000235:genetics / Q000276:immunology* / Q000628:therapy
D000906:Antibodies; D006680:HLA Antigens
Neutropenie néo-natale par allo-immunisation anti-na 2. Etude clinique et serologique de 2 cas dans une famille.