The stimulatory effect of human PMNI lysosomes on lymphocytes in vitro and in vivo.
The proteins isolated from human PMNL lysosome granules have activated the lymphocytes in vitro. It was found that T cells undergo transformation in response to lysosome mitogens but no LIF production was observed. Transformation induced by PHA, PWM and Con A was depressed in the presence of lysosome mitogens. The in vivo response to T-dependent antigens is amplified by lysosome mitogens. The above experiments demonstrate that lysosome mitogens stimulate T lymphocytes.
D000818:Animals; D000917:Antibody Formation; D006168:Guinea Pigs; D006801:Humans; D037102:Lectins / Q000494:pharmacology; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D008222:Lymphokines / Q000096:biosynthesis; D008247:Lysosomes / Q000201:enzymology / Q000502:physiology; D051379:Mice; D009504:Neutrophils / Q000276:immunology* / Q000648:ultrastructure; D010447:Peptide Hydrolases / Q000378:metabolism
D037102:Lectins; D008222:Lymphokines; D010447:Peptide Hydrolases