Ethanol and heat-treated plasma fractionation methods in South Africa.
Modifications of the Cohn techniques are the methods of choice for the preparation fo dilute albumin (PPS) and gamma-globulin solutions on an industrial scale. For the manufacture of refined albumin solutions, however, considerable labour and material is saved if crude, ethanol-precipitated fractions are heated in the presence of stabilisers in order to purify the albumin. The technique is simple and cheap, and yields a safe product of high quality. Bacterially contaminated and highly haemoglobinized plasma can be successfully heat-treated.
D000818:Animals; D005591:Chemical Fractionation; D000431:Ethanol / Q000494:pharmacology*; D006454:Hemoglobins; D006358:Hot Temperature; D006801:Humans; D010949:Plasma; D011309:Preservation, Biological; D011817:Rabbits; D012709:Serum Albumin; D012965:Sodium Chloride / Q000494:pharmacology; D013019:South Africa
D006454:Hemoglobins; D012709:Serum Albumin; D000431:Ethanol; D012965:Sodium Chloride