Myelofibrosis with complex chromosome abnormality in a patient with erythrocytosis due to hemoglobin Rainier and treated with 32P.
A patient with familial erythrocytosis associated with Hemoglobin Rainier, and previously treated with 32P, developed myelofibrosis with a hyperdiploid chromosome clone in the myeloid cells (51,XX,+1,2q-(q33),+6,+9,+11,-19,+20q+,+mar 1.) This transformation from a benign disorder of differentiated erythrocytes to a malignant disorder may have been secondary to radiophosphorus therapy.
D002869:Chromosome Aberrations / Q000097:blood*; D025063:Chromosome Disorders; D005260:Female; D006455:Hemoglobins, Abnormal; D006801:Humans; D007621:Karyotyping; D008875:Middle Aged; D010761:Phosphorus Radioisotopes / Q000627:therapeutic use*; D011086:Polycythemia / Q000097:blood / Q000150:complications* / Q000235:genetics / Q000628:therapy; D055728:Primary Myelofibrosis / Q000097:blood / Q000150:complications* / Q000235:genetics; D014861:Washington
D006455:Hemoglobins, Abnormal; D010761:Phosphorus Radioisotopes