In vitro studies of the metabolic pathway from 8-COOH porphyrins to 4-COOH porphyrins.
The authors report the experiments about incubation of uroporphyrinogen with sonified fibroblasts of normal individuals and prophyrics and present the hypothesis of the absence of deficiency in the activity of uroporphyrinogendecarboxylase.
D003305:Coproporphyrinogens / Q000378:metabolism; D003653:Decarboxylation; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D011164:Porphyrias / Q000378:metabolism*; D011165:Porphyrinogens / Q000378:metabolism*; D011166:Porphyrins / Q000652:urine; D014575:Uroporphyrinogen Decarboxylase / Q000172:deficiency; D014577:Uroporphyrinogens / Q000378:metabolism*
D003305:Coproporphyrinogens; D011165:Porphyrinogens; D011166:Porphyrins; D014577:Uroporphyrinogens; D014575:Uroporphyrinogen Decarboxylase