Glucose therapy of recurrent lactic acidosis.
Lactic acidosis not associated with hypoxic states has a high morbidity and mortality. Treatment of this condition has been supportive and the etiology poorly understood. We report a case of recurrent lactic acidosis in a patient with renal and hepatic insufficiency with hypoglycemia which was repeatedly reversed by restoring the glucose concentration to normal. This case and several others in the literature suggest a mechanism for the development of type II B hyperlactatemia and new approaches for therapy.
D000138:Acidosis / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D000328:Adult; D005947:Glucose / Q000627:therapeutic use*; D006801:Humans; D007003:Hypoglycemia / Q000150:complications / Q000188:drug therapy / Q000378:metabolism; D007674:Kidney Diseases / Q000378:metabolism; D007773:Lactates / Q000378:metabolism*; D008107:Liver Diseases / Q000378:metabolism; D008297:Male; D010101:Oxygen Consumption; D011773:Pyruvates / Q000378:metabolism; D012008:Recurrence
D007773:Lactates; D011773:Pyruvates; D005947:Glucose