Malonaldehyde formation in intact platelets is catalysed by thromboxane synthase.
Imidazole and compound L8027 (selective inhibitors of thromboxane synthase) produced parallel inhibition of malonaldehyde and thromboxane B2 secretion induced by collagen or thrombin in gel-filtered suspensions of human platelets. Comparing the effects of these inhibitors and aspirin on secretion of granule constituents indicated that platelet degranulation depends mainly on thromboxane production; prostaglandin endoperoxides contributed little.
D001792:Blood Platelets / Q000201:enzymology*; D006801:Humans; D066298:In Vitro Techniques; D008314:Malonates / Q000096:biosynthesis*; D008315:Malondialdehyde / Q000096:biosynthesis*; D010088:Oxidoreductases / Q000378:metabolism*; D013929:Thromboxane B2 / Q000378:metabolism; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors / Q000378:metabolism*
D008314:Malonates; D008315:Malondialdehyde; D013929:Thromboxane B2; D010088:Oxidoreductases; D013930:Thromboxane-A Synthase