Pathogenetic mechanisms in tubular renal disease.
Injections of heterologous tubular material into rabbits caused the formation of immune complexes deposited predominantly on the tubular basement membrane. Much fainter deposits were found on the glomerular basement membrane. Immunohistological studies revealed that the antigen involved originated from cells of the proximal tubules. In other animal experiments, purified tubular material was used for immunisation in order to analyse the antigenic structure of renal tubules. These rabbits were found to produce autoantibodies against an antigen present in the tubular as well as the glomerular basement membrane. Morphological studies of the kidneys from the immunised animals revealed alterations in the tubular epithelial cells and interstitial tissue which were characterised microscopically and electron microscopically by swelling and degeneration of the epithelial cells, and cellular infiltrates in the interstitium.
D000818:Animals; D000917:Antibody Formation; D000936:Antigen-Antibody Complex; D007674:Kidney Diseases / Q000276:immunology* / Q000473:pathology; D007684:Kidney Tubules / Q000276:immunology* / Q000473:pathology; D011817:Rabbits
D000936:Antigen-Antibody Complex