Quantitative determination of propildazine in rat plasma by gas-liquid chromatography.
A gas-liquid chromatographic method for the evaluation of the new anti-hypertensive drug propildazine (ISF 2123) in rat plasma is described. The procedure involves separation of the drug from plasma by cation-exchange chromatography, subsequent acylation of the dried eluate with heptafluorobutyric anhydride and quantitation with electron-capture detection. Propildazine can be determined in concentrations down to ca. 0.4 microgram/ml.
D000818:Animals; D000959:Antihypertensive Agents / Q000097:blood*; D002849:Chromatography, Gas; D002853:Chromatography, Liquid; D006834:Hydrazines / Q000097:blood; D008832:Microchemistry; D011724:Pyridazines / Q000097:blood*; D051381:Rats
D000959:Antihypertensive Agents; D006834:Hydrazines; D011724:Pyridazines