title: [Toxic effects of essential oil of Cannabis sativa L. and main constituents on planarian (Dugesia tigrina) (author's transl)].
abstract: Regenerating pieces of planarian worms are able to absorbe insoluble substances deposited on the base of the vessels in which they are cultivated. This biological test was used to study the toxic effects of the essential oil of Cannabis sativa L. The hydrocarbons such as pinene (alpha and beta), caryophyllene and so on were not toxic. On the contrary caryophyllene oxide was highly toxic. It was not possible to detect any protection by 5-hydroxytryptamine as it was the case against delta 1-tétrahydro-cannabinol and cannabidiol.
mesh_terms: D000818:Animals; D002188:Cannabis / Q000032:analysis; D007928:Lethal Dose 50; D009821:Oils / Q000302:isolation & purification / Q000633:toxicity*; D010932:Planarians / Q000187:drug effects*; D012038:Regeneration / Q000187:drug effects; D012701:Serotonin / Q000494:pharmacology; D014419:Turbellaria / Q000187:drug effects*
chemical_list: D009821:Oils; D012701:Serotonin
vernacular_title: Etude de la toxicité de l'huile essentielle de Cannabis sativa L. et de ses principaux constituants sur la planaire (Dugesia tigrina G.).