[Effect of serotonin and malate benzyl hydrazine on glutathione peroxidase and lipid peroxidation by rat heart and liver mitochondria].
The effect of serotonin and malate benzyl hydrazine (inhibitor MAO) on the activity of glutathione peroxidase and intensity of ascorbate-dependent peroxidation of lipids in mitochondria was investigated. Serotonin injected intraperitoneally at a concentration of 20 m/kg increased activity of glutathione peroxidase in liver mitochondria and nonfermented ascorbate-dependent peroxidation of lipids in heart mitochondria. In experiments in vitro serotonin and malate benzyl hydrazine decreased activity of glutathione peroxidase an inhibited nonfermented ascorbate-dependent peroxidation in mitochondria of the heart and liver of rats.
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology; D005979:Glutathione Peroxidase / Q000378:metabolism*; D006834:Hydrazines / Q000494:pharmacology*; D050356:Lipid Metabolism; D008293:Malates / Q000494:pharmacology; D008929:Mitochondria, Heart / Q000187:drug effects / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D010544:Peroxidases / Q000378:metabolism*; D010545:Peroxides / Q000378:metabolism; D051381:Rats; D012701:Serotonin / Q000494:pharmacology*
D006834:Hydrazines; D008293:Malates; D010545:Peroxides; D012701:Serotonin; D010544:Peroxidases; D005979:Glutathione Peroxidase; D001205:Ascorbic Acid
Vliianie serotonina i benzilgidrazina iablochnoĭ kisloty na aktivnost' gliutationperoksidazy i na perekisnoe okislenie lipidov v mitokhondriiakh aktivnost' gliutationperoksidazy i na perekisnoe okislenie lipidov v mitokhondriiakh serdtsa i pecheni krys.