Constituents of chyme responsible for postprandial intestinal hyperemia.
While local venous outflow was measured in anesthetized dogs, various constituents of intestinal chyme were placed in the jejunal lumen to identify those responsible for postprandial intestinal hyperemia. Digested food and its supernatant increased local blood flow, whereas its precipitate, undigested food, and pancreatic enzymes did not. In the jejunum bile alone had no effect, but it markedly enhanced the hyperemic effect of digested food. Bile in the ileal lumen, however, increased local blood flow. At physiological postprandial concentrations in the jejunum, glucose, and micellar solutions of oleic acid and monoolein increased flow, but taurocholate and 16 common dietary amino acids did not. The hyperemic effect of lipids required the presence of taurocholate. Of the 16 amino acids, only Glu and Asp increased flow at 10 times the physiological concentrations (28 and 20 mM, respectively). The study indicates that the constituents of chyme responsible for postprandial intestinal hyperemia are the hydrolytic products of food, especially those of carbohydrates and fats and that bile plays an important role in the hyperemia.
D000596:Amino Acids / Q000494:pharmacology; D000818:Animals; D001647:Bile Acids and Salts / Q000494:pharmacology; D004285:Dogs; D005227:Fatty Acids / Q000494:pharmacology; D005260:Female; D005502:Food; D005947:Glucose / Q000494:pharmacology; D005989:Glycerides / Q000494:pharmacology; D006940:Hyperemia; D007583:Jejunum / Q000098:blood supply*; D008297:Male; D012039:Regional Blood Flow
D000596:Amino Acids; D001647:Bile Acids and Salts; D005227:Fatty Acids; D005989:Glycerides; D005947:Glucose