Elucidation of the receptor-bound conformation of the enkephalins.
The biologically relevant conformers of enkephalin predicted by solid state, solution state, and theoretical energy studies have been compared with the published structure-activity data on these compounds. No conformational technique proposes a model consistent with all the pharmacological data; the shortcomings of each approach are evaluated. An alternative approach, which correlates the structure-activity data of opiate compounds with that of the enkephalins, is described and shown to produce a model consistent with the available structure-activity data.
D004723:Endorphins / Q000378:metabolism; D004745:Enkephalins / Q000378:metabolism; D006860:Hydrogen Bonding; D009682:Magnetic Resonance Spectroscopy; D009294:Narcotics; D011487:Protein Conformation; D011955:Receptors, Drug / Q000378:metabolism; D013329:Structure-Activity Relationship; D013816:Thermodynamics; D014961:X-Ray Diffraction
D004723:Endorphins; D004745:Enkephalins; D009294:Narcotics; D011955:Receptors, Drug