title: [A biological approach to the problem of dose fractionation in radiotherapy (author's transl)].
abstract: The role of what has come to be called "the four R's" of modern radiobiology is reviewed from a general and applied point of view. Especially, repair of subletal damage, redistribution of cells within their cycle, tissue repopulation, cell reoxygenation, are considered with attention to their intervention in the sterilization of tumor clonogenic cells in human radiotherapy.
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000528:radiation effects; D002455:Cell Division / Q000528:radiation effects; D002468:Cell Physiological Phenomena; D002470:Cell Survival; D002477:Cells / Q000528:radiation effects*; D004735:Energy Transfer; D006801:Humans; D009369:Neoplasms / Q000378:metabolism / Q000532:radiotherapy*; D010084:Oxidation-Reduction; D010100:Oxygen / Q000502:physiology; D011836:Radiation Tolerance; D011879:Radiotherapy Dosage; D012062:Relative Biological Effectiveness
chemical_list: D010100:Oxygen
vernacular_title: Problemi biologici in radioterapia legati al frazionamento della dose.