Effects of chronic oral dosing with quinine sulphate in the rat.
Male Leeds strain rats were given 0.1% guinine sulphate in their drinking water for up to 15 months. A high mortality rate was obtained, but no tumours arose during the 20 month duration of the experiment. However, liver parenchymal changes were observed which appeared to be associated with chronic toxicity due to quinine and did not include hyperplasia.
D000818:Animals; D007928:Lethal Dose 50; D008099:Liver / Q000187:drug effects* / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D011803:Quinine / Q000633:toxicity*; D051381:Rats; D013997:Time Factors
D011803:Quinine