Impairments of glycogen and drug metabolisms by chloropeptide, a hepatotoxic mycotoxin of Penicillium islandicum sopp.
Administration of chloropeptide, a hepatotoxic cyclic pentapeptide of Penicillium islandicum Sopp, caused a marked decline in the hepatic glycogen synthetase activity with concomitant increase in NADP-dependent G-6-P dehydrogenase activity. The microsomalmixed function oxygenases were also reduced in the liver of rats following chloropeptide treatment.
D000818:Animals; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008112:Liver Glycogen / Q000378:metabolism*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009183:Mycotoxins / Q000494:pharmacology*; D009842:Oligopeptides / Q000494:pharmacology; D010407:Penicillium; D010456:Peptides, Cyclic / Q000494:pharmacology*; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D051381:Rats; D013347:Subcellular Fractions / Q000187:drug effects / Q000378:metabolism
D008112:Liver Glycogen; D009183:Mycotoxins; D009842:Oligopeptides; D010456:Peptides, Cyclic; D004364:Pharmaceutical Preparations; C018925:chloropeptide