Self-inhibitory dopamine-receptors and central effects of apomorphine.
Apomorphine, a central dopamine-receptor agonist, is well known to produce excitatory effects in animals. However, low doses exert depressant effects as hypomotility, sedation and sleep. The mechanism of these effects are discussed in terms of a stimulation by apomorphine of DA-receptors, different from the post-synaptic ones, provided of an inhibitory effect on DA-synthesis and on the firing of dopaminergic neurons.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001544:Benperidol / Q000494:pharmacology; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D003024:Clozapine / Q000494:pharmacology; D004329:Droperidol / Q000494:pharmacology; D005106:Exploratory Behavior / Q000187:drug effects; D006220:Haloperidol / Q000494:pharmacology; D006801:Humans; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010868:Pimozide / Q000494:pharmacology; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects*; D012890:Sleep / Q000187:drug effects
D011954:Receptors, Dopamine; D010868:Pimozide; D001544:Benperidol; D003024:Clozapine; D006220:Haloperidol; D001058:Apomorphine; D004329:Droperidol