Stimulation by growth hormone of somatostatin release from the rat hypothalamus in vitro.
Growth hormone (GH) has been shown to cause a dose-dependent increase in the release of immunoreactive somatostatin from the rat hypothalamus in vitro, thus providing further evidence that GH may be involved in a "short loop" feedback, controlling its own secretion via hypothalamic somatostatin release.
D000818:Animals; D013006:Growth Hormone / Q000494:pharmacology*; D007031:Hypothalamus / Q000187:drug effects* / Q000378:metabolism; D066298:In Vitro Techniques; D011189:Potassium Chloride / Q000494:pharmacology; D051381:Rats; D013004:Somatostatin / Q000378:metabolism*; D013972:Thyrotropin; D014702:Veratrine / Q000494:pharmacology
D013004:Somatostatin; D011189:Potassium Chloride; D013972:Thyrotropin; D013006:Growth Hormone; D014702:Veratrine