Inhibition of kidney tubule induction by charged polymers.
Charged polymers, known to alter cell surface characteristics, reversibly inhibit the intercellular communication required in kidney tubule induction. This effect seems to be a function of their charge density. It is suggested that this effect is due to the formation of a molecular barrier between the interacting cell surfaces.
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects*; D002809:Chondroitin Sulfates / Q000494:pharmacology; D046508:Culture Techniques; D003911:Dextrans / Q000494:pharmacology; D004627:Embryonic Induction / Q000187:drug effects*; D006493:Heparin / Q000494:pharmacology; D007684:Kidney Tubules / Q000187:drug effects* / Q000196:embryology / Q000378:metabolism; D051379:Mice; D011107:Polylysine / Q000494:pharmacology; D011108:Polymers / Q000494:pharmacology*
D003911:Dextrans; D011108:Polymers; D011107:Polylysine; D006493:Heparin; D002809:Chondroitin Sulfates