[Metabolic status of acute myocardial infarction as a function of residual blood flow with and without revascularization].
In mongrel dogs anesthetized with Nembutal, the left anterior descending coronary artery was ligated for 2 h. The residual blood flow (RBF) was correlated with tissue levels of various myocardial metabolites after 1 and 24 h and 7 days of reperfusion. ATP and the sum of adeninnucleotides showed a better recovery with an increasing RBF. Initial increased value of creatine phosphate was followed by a decrease to subnormal values, which cannot be sufficiently explained. There was an accelerated overshoot beyond normal values in glycogen levels after 7 days with increasing RBF. After 7 days there was no recovery to normal values, and below a RBF of 5 ml/100 g/min metabolic recovery was poor.
D000227:Adenine Nucleotides / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D003326:Coronary Circulation; D004285:Dogs; D005260:Female; D006003:Glycogen / Q000378:metabolism; D008297:Male; D009203:Myocardial Infarction / Q000378:metabolism*; D009204:Myocardial Revascularization; D010725:Phosphocreatine / Q000378:metabolism; D013997:Time Factors
D000227:Adenine Nucleotides; D010725:Phosphocreatine; D000255:Adenosine Triphosphate; D006003:Glycogen
Stoffwechselstatus des akut infarzierten Myokards in Abhängigkeit von der Restdurchblutung ohne und mit Revascularisation.