An improved 11 alpha-hydroxylation of progesterone by Aspergillus ochraceus TS.
1. The stereospecific hydroxylation of progesterone exclusively to its 11 alpha-hydroxy derivative by Aspergillus ochraceus TS is reported. 2. There is no secondary metabolite (6beta, 11 alpha-dihydroxyprogesterone) formed even when the transformation was attempted with different concentrations of the substrate (200 microgram/ml-200 mg/ml) for prolonged with Zn2+ at a concentration of 50 microgram/ml identical results were obtained. 3. Similar results were also obtained at different pH values of the culture medium.
D001230:Aspergillus / Q000378:metabolism*; D006900:Hydroxylation; D006908:Hydroxyprogesterones / Q000096:biosynthesis*; D011374:Progesterone / Q000378:metabolism*
D006908:Hydroxyprogesterones; D011374:Progesterone