Renal accumulation of amikacin, tobramycin and gentamycin in the rat.
Free and total concentrations of amikacin, tobramycin and gentamycin were measured separately in the rat kidney after equal weight by weight doses. The accumulation of aminoglycosides followed the order amikacin less than tobramycin less than gentamycin. The ratio between free and total aminoglycosides was similar (about 0.6) in all 3 aminoglycosides and independent on the length of administration.
D000583:Amikacin / Q000378:metabolism*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005839:Gentamicins / Q000378:metabolism*; D007612:Kanamycin / Q000031:analogs & derivatives*; D007668:Kidney / Q000378:metabolism*; D007674:Kidney Diseases / Q000139:chemically induced; D051381:Rats; D012995:Solubility; D014031:Tobramycin / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D007612:Kanamycin; D000583:Amikacin; D014031:Tobramycin