title: Regional diastolic coronary blood flow during diastolic ventricular hypertension.
abstract: The effect of diastolic ventricular hypertension on regional diastolic coronary flow was measured with radioactive microspheres in the canine heart paced at a constant rate and perfused only during diastole with a constant coronary perfusion pressure. Diastolic ventricular hypertension produced an homogenous increase of diastolic flow across the left ventricular wall when the metabolic coronary autoregulation was intact, but produced a decrease in subendocardial diastolic flow when the autoregulation was abolished. These results suggest that diastolic ventricular hypertension produces a higher subendocardial than subepicardial mechanical resistance to diastolic coronary flow.
mesh_terms: D000818:Animals; D003326:Coronary Circulation; D003971:Diastole; D004285:Dogs; D006339:Heart Rate; D006706:Homeostasis; D006973:Hypertension / Q000503:physiopathology*; D009200:Myocardial Contraction; D010477:Perfusion; D011312:Pressure; D016276:Ventricular Function