Activity of sulfamethoxazole trimethoprim against Bacteroides fragilis.
The author tested parallely 35 Bacteroides fragilis strains by the agar diffusion method and disk technique. A notable discrepancy appears between these two procedures. No regression line can be constructe and the inhibition diameter measurement is unable to class the strain in "susceptible" or "resistant". A literature review on this theme shows that the dissociation between these two techniques were more frequent with anaerobic strains than aerobic for SMX + TMP as others antibiotics. The MIC determination by an agar dilution is the only able to these studies.
D001442:Bacteroides Infections / Q000382:microbiology*; D001441:Bacteroides fragilis / Q000187:drug effects* / Q000254:growth & development; D004357:Drug Synergism; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods*; D013420:Sulfamethoxazole / Q000494:pharmacology*; D014295:Trimethoprim / Q000494:pharmacology*
D014295:Trimethoprim; D013420:Sulfamethoxazole