The timing of cyclophosphamide therapy in tumor-bearing rats affects the resistance to tumor challenge in survivors.
Cyclophosphamide given to rats 2 or 5 days after an injection of Yoshida ascites sarcoma cured approximately the same proportion of animals, but the resistance to a subsequent tumor challenge was found only in rats treated with the drug 5 days after tumor injection.
D000818:Animals; D003520:Cyclophosphamide / Q000008:administration & dosage* / Q000627:therapeutic use; D004334:Drug Administration Schedule; D005260:Female; D007165:Immunosuppression Therapy; D008297:Male; D051381:Rats; D012517:Sarcoma, Yoshida / Q000188:drug therapy* / Q000276:immunology
D003520:Cyclophosphamide