Inhibition of exocrine pancreatic secretion by somatostatin in dogs.
The effect of somatostatin on the pancreatic exocrine response to different doses of exogenous stimuli and the somatostatin dose-response relationships on pancreatic secretion were studied in conscious dogs. Somatostatin caused a strong inhibition of basal or slightly stimulated pancreatic secretion but failed to inhibit the maximal responses, suggesting that somatostatin interacts with secretin or caerulein by a competitive mechanism. A higher maximal percentage of inhibition and a dose-response relationship was observed with protein outputs and enzyme concentrations. Volumes and bicarbonate outputs were also inhibited but the maximal percentage of inhibition was lower.
D000818:Animals; D001639:Bicarbonates / Q000378:metabolism; D002108:Ceruletide / Q000008:administration & dosage / Q000494:pharmacology; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D010179:Pancreas / Q000378:metabolism*; D010189:Pancreatic Juice / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism; D012633:Secretin / Q000008:administration & dosage / Q000494:pharmacology; D012636:Secretory Rate / Q000187:drug effects; D013004:Somatostatin / Q000008:administration & dosage / Q000494:pharmacology*
D001639:Bicarbonates; D011506:Proteins; D012633:Secretin; D013004:Somatostatin; D002108:Ceruletide