Effect of ionic and non-ionic contrast media on whole blood viscosity, plasma viscosity and hematocrit in vitro.
The effect of the ionic contrast media diatrizoate, iocarmate and metrizoate and the non-ionic metrizamide on whole blood viscosity, plasma viscosity and hematocrit was investigated. All the contrast media increased whole blood and plasma viscosity and reduced the hematocrit. The whole blood viscosity increased with increasing osmolality of the contrast medium solutions, whereas the plasma viscosity increased with increasing viscosity of the contrast medium solutions. The higher the osmolality of the contrast media, the lower the hematocrit became. The normal shear-thinning (decreasing viscosity with increasing shear rate) property of blood was reduced when contrast medium was added to the blood. At 50% volume ratio (contrast medium to blood), the ionic contrast media converted the blood into a shear-thickening (increasing viscosity with increasing shear rate) suspension, indicating a marked rigidification of the single red cell, while the non-ionic contrast medium still produced shear-thinning, indicating less rigidification of the red cell (p less than 0.01).
D001809:Blood Viscosity / Q000187:drug effects*; D003287:Contrast Media / Q000494:pharmacology*; D003974:Diatrizoate Meglumine / Q000494:pharmacology; D004911:Erythrocyte Volume / Q000187:drug effects*; D006400:Hematocrit; D006801:Humans; D007482:Iothalamate Meglumine / Q000494:pharmacology; D008536:Meglumine / Q000494:pharmacology; D008793:Metrizamide / Q000494:pharmacology; D008794:Metrizoic Acid / Q000494:pharmacology; D009994:Osmolar Concentration
D003287:Contrast Media; D003974:Diatrizoate Meglumine; D008536:Meglumine; D008794:Metrizoic Acid; D008793:Metrizamide; D007482:Iothalamate Meglumine