title: Althesin infusion and regional blockade anaesthesia for major gynaecological surgery.
abstract: The effects of an infusion of a 10% Althesin solution to induce sleep in patients undergoing major gynaecological surgery performed under extradural analgesia are presented. There was no significant depressant effect on the cardiovascular system, but a predictable and preventable depression of respiratory function. Liver function tests were unaffected by the infusion. Operating conditions were satisfactory in all patients and postoperative recovery was smooth and uncomplicated.
mesh_terms: D000328:Adult; D000368:Aged; D000530:Alfaxalone Alfadolone Mixture / Q000008:administration & dosage / Q000494:pharmacology; D000767:Anesthesia, Epidural; D000771:Anesthesia, Intravenous; D002245:Carbon Dioxide / Q000097:blood; D003243:Consciousness / Q000187:drug effects; D005260:Female; D005831:Genital Diseases, Female / Q000601:surgery; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008111:Liver Function Tests; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D011277:Pregnanediones / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D011277:Pregnanediones; D002245:Carbon Dioxide; D000530:Alfaxalone Alfadolone Mixture; D010100:Oxygen