title: Maintenance of permanently implanted cardiac pressure catheters in experimental animals.
abstract: Two techniques for maintaining permanently implanted cardiac catheters in experimental animals are described. Polyvinylchloride catheters are coated with TDMAC-Heparin, a polymer complex currently used clinically to prevent thrombogenesis in vascular shunts. Long-term catheter obstruction and thrombus formation have been obviated by using this method. Also, to assure multiple, painless studies in awake animals, a somewhat different technique for pressure catheter access has been developed and is detailed in this report.
mesh_terms: D000818:Animals; D000830:Animals, Laboratory; D006328:Cardiac Catheterization / Q000295:instrumentation / Q000379:methods*; D002408:Catheters, Indwelling; D004285:Dogs; D005069:Evaluation Studies as Topic; D006493:Heparin; D011108:Polymers; D011143:Polyvinyl Chloride; D013927:Thrombosis / Q000517:prevention & control; D013997:Time Factors
chemical_list: D011108:Polymers; D011143:Polyvinyl Chloride; D006493:Heparin