Renal effects of propranolol, practolol and butoxamine in pentobarbital-anesthetized rats.
The renal effects of the beta-adrenergic blockers, propranolol, practolol and butoxamine, were examined in pentobarbital-anesthetized rats. All the beta-blockers, infused i.v., increased urine volume (V), urinary sodium excretion (UNaV) and p-aminohippuric acid clearance without change in inulin clearance. Indomethacin, an inhibitor of prostaglandin biosynthesis, did not affect the renal effects of these beta-blockers. Phentolamine abolished the renal effects of practolol, but not those of propranolol and butoxamine. Haloperidol abolished the renal effects of propranolol and butoxamine, but not those of practolol. A high correlation was found between the increased UNaV and the increased urinary phosphate excretion by butoxamine but not by propranolol and practolol. Therefore, it is suggested that alpha-adrenergic stimulation is involved in the mechanism of diuresis by practolol, a beta1-blocker, and that dopaminergic stimulation is involved in the diuresis caused by butoxamine, a beta2-blocker. Propranolol is similar to butoxamine, and partially similar to practolol.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002078:Butoxamine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004231:Diuresis / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006220:Haloperidol / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D007213:Indomethacin / Q000494:pharmacology; D007545:Isoproterenol / Q000037:antagonists & inhibitors; D007668:Kidney / Q000187:drug effects*; D008297:Male; D010646:Phentolamine / Q000494:pharmacology; D011217:Practolol / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D011412:Propanolamines / Q000494:pharmacology*; D011433:Propranolol / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats
D011412:Propanolamines; D002078:Butoxamine; D011433:Propranolol; D006220:Haloperidol; D007545:Isoproterenol; D011217:Practolol; D007213:Indomethacin; D010646:Phentolamine