Lysine in treatment of hyperornithinemia.
A metabolic study in a case of hyperornithinemia with gyrate atrophy of choroid and retina is presented. It is demonstrated that the lysine-ornithine antagonism is a physiological, safe, easy to handle therapeutic tool in hyperornithinemia. A lysine load was invariably associated with a reduction of plasma ornithine concentration. This happened at any level of protein intake. It was also shown that diets containing a low protein intake are invariably associated with negative nitrogen balance.
D001120:Arginine; D001284:Atrophy; D002675:Child, Preschool; D002829:Choroid / Q000473:pathology; D004044:Dietary Proteins / Q000378:metabolism; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D008239:Lysine / Q000627:therapeutic use*; D009584:Nitrogen / Q000378:metabolism; D009952:Ornithine / Q000097:blood*; D012160:Retina / Q000473:pathology; D014508:Urea / Q000096:biosynthesis
D004044:Dietary Proteins; D014508:Urea; D001120:Arginine; D009952:Ornithine; D008239:Lysine; D009584:Nitrogen