Picrotoxin-diazepam interaction in a behavioural schedule of differential reinforcement of low rates.
In rats working in a behavioural schedule of differential reinforcement of low rates (6 or 10 sec), picrotoxin (1 mg kg-1) decreased the number of premature responses and increased (in DRL 10 sec only) the number of rewarded responses. The effect of picrotoxin was antagonized by diazepam (2 mg kg-1). In contrast to picrotoxin, strychnine (1.5 mg kg-1) increased the number of premature responses.
D000818:Animals; D003216:Conditioning, Operant / Q000187:drug effects*; D003975:Diazepam / Q000494:pharmacology*; D008297:Male; D010852:Picrotoxin / Q000037:antagonists & inhibitors*; D051381:Rats; D012055:Reinforcement Schedule; D013331:Strychnine / Q000494:pharmacology
D003975:Diazepam; D010852:Picrotoxin; D013331:Strychnine