Relationship between oestrogen-receptor content and histological grade in human primary breast tumours.
A series of 300 patients presenting consecutively with primary operable breast cancer has been studied. A significant correlation was found between oestrogen-receptor (ER) content and histological grade: the better-differentiated tumours rarely lacked receptor. This correlation was significant only in women defined as post-menopausal. Data on early recurrence of disease indicate a worse prognosis for women in whom primary tumours are ER-.
D000328:Adult; D000368:Aged; D001859:Bone Neoplasms; D001943:Breast Neoplasms / Q000032:analysis / Q000473:pathology*; D002471:Cell Transformation, Neoplastic; D005260:Female; D006801:Humans; D008175:Lung Neoplasms; D008198:Lymph Nodes / Q000473:pathology; D008408:Mastectomy; D008593:Menopause; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D011960:Receptors, Estrogen / Q000032:analysis*
D011960:Receptors, Estrogen