[Effect of florenal on reproduction of influenza virus].
The antiviral, viricidal, and interferon-inducing activities of florenal (bisulphite derivative of 2-flourenylglyoxal) and its influence on RNA and protein synthesis were studied. The drug inhibited replication of A/WSN and A/Englang/42/72 influenza viruses in chick embryos infected with low doses of the viruses (10--1000 EID50), induced interferon production in cell culture and in chick embryos (16 and 32 units/ml, respectively) and showed viricidal activity in vitro. Florenal in concentrations 50 microgram/ml or higher reduced the level of RNA and protein synthesis both in non-infected and infected cells within the first 4--5 hours after its administration. It was not effective against influenza infection of white mice caused by A/England/42/72 virus.
D000218:Adamantane / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002478:Cells, Cultured; D002642:Chick Embryo; D004305:Dose-Response Relationship, Drug; D005449:Fluorenes / Q000494:pharmacology* / Q000627:therapeutic use; D006037:Glyoxal / Q000031:analogs & derivatives / Q000494:pharmacology; D009980:Influenza A virus / Q000187:drug effects*; D007369:Interferon Inducers; D008297:Male; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000188:drug therapy; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D005449:Fluorenes; D007369:Interferon Inducers; D006037:Glyoxal; D012313:RNA; D000218:Adamantane
Vliianie florenalia na reproduktsiiu virusa grippa.