title: [Use of the plaque method to reveal the phenomenon of autointerference in influenza virus].
abstract: The paper describes a simple and convenient method for qualitative and quantitative evaluation of the capacity of influenza virus for autointerference consisting in the lack or considerable reduction of the cytolytic effect of the virus under agar overlay at a high multiplicity of infection. Some experimental and theoretical arguments assuming the role of defective interfering particles in the formation of the observed phenomenon. It is assumed that the detection of autointerference under agar may be used as an additional criterion for detection of non-plaque-forming strains of influenza virus, tentative determination of their interfering capacity as well as for the establishment of biological relationships of viruses.
mesh_terms: D003673:Defective Viruses; D009980:Influenza A virus / Q000502:physiology*; D014762:Viral Interference; D010948:Viral Plaque Assay
vernacular_title: Ispol'zovanie metoda bliashek dlia vyiavleniia fenomena autointerferentsii u virusa grippa.