Docosahexaenoic acid in cardiac metabolism and function.
The polyene fatty acid compostition of cardiac phospholipids is modified by a) dietary cod liver oil, b) norepinephrine, c) chronic administration of nicotine to animals fed a high cholesterol diet. Polyene fatty acids stimulate microsomal oxydation of epinephrine to cardiotoxic adrenochrome. Adrenochrome stimulates microsomal peroxydation or oxygenation of polyene fatty acids. There is an exponential relationship between docosahexaenoic acid of cardiac phospholipids and the heart rate.
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D003060:Cod Liver Oil; D004041:Dietary Fats; D004837:Epinephrine / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D009538:Nicotine / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D010101:Oxygen Consumption; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D014810:Vitamin E / Q000494:pharmacology
D004041:Dietary Fats; D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D008563:Membrane Lipids; D010743:Phospholipids; D014810:Vitamin E; D009538:Nicotine; D003060:Cod Liver Oil; D007545:Isoproterenol; D009638:Norepinephrine; D004837:Epinephrine