title: [Possible interference between tetanus toxin and organo-phosphorus esters in blocking of cholinesterase].
abstract: As tetanus toxin results inactivated when mixed with mammals brain homogenate (Wassermann-Takaki phenomenon), the same may be observed for the organophosphorus compounds. When the brain homogenates are mixed before with one of both poisons and subsequently, after incubation, with the other, this one keeps its typical toxic activity. This behavior seems to be interpreted as the result from the linkage between the true cholinesterase and one toxic (Wassermann-Takaki phenomenon both for the tetanus toxin and the "parathion"), with the following interference for the second toxic, when added, at the enzymatic level, so that the second toxic remains free.
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D002802:Cholinesterases / Q000378:metabolism*; D004347:Drug Interactions; D005260:Female; D006168:Guinea Pigs; D010278:Parathion / Q000506:poisoning*; D013744:Tetanus Toxin / Q000494:pharmacology*
chemical_list: D013744:Tetanus Toxin; D010278:Parathion; D002802:Cholinesterases
vernacular_title: Possibile interferenza tra tossina tetanica ed esteri organo-fosforici nel blocco della colinesterasi.