title: [Experimental investigations concerning a topical application of sisomicin in the eye (author's transl)].
abstract: Sisomicin is a new aminoglycoside, which sometimes is active against bacterial isolates resistant to other antibiotics of this group. The compatibility of sisomicin and its penetration into the different tissues of the eye were studied in rabbits. The substance was well tolerated, when applied as drops or injected subconjunctivally. Concentrations of sisomicin which are effective against most bacteria were found in the cornea and in the aqueous humour, but it did not penetrate into the vitreous body.
mesh_terms: D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism; D003228:Conjunctiva; D003315:Cornea / Q000378:metabolism; D005123:Eye / Q000378:metabolism*; D005839:Gentamicins / Q000378:metabolism*; D007267:Injections; D009883:Ophthalmic Solutions; D011817:Rabbits; D012853:Sisomicin / Q000008:administration & dosage / Q000378:metabolism*; D013997:Time Factors; D014018:Tissue Distribution; D014822:Vitreous Body / Q000378:metabolism
chemical_list: D005839:Gentamicins; D009883:Ophthalmic Solutions; D012853:Sisomicin
vernacular_title: Experimentelle Untersuchungen zur lokalen Anwendung von Sisomicin am Auge.