[Thyroid secretion in experimental hyperplasia (author's transl)].
Hyperactive dog thyroids were prepared by repeated TSH stimulation in vivo. Butanol extractable 125iodine (BE 125I) release in vitro from such hyperactive thyroid slices was enhanced when compared with resting slices. Apical pseudopods an colloid droplets were exceptional in such hyperactive thyroids. Moreover, BE125I release was intensitive to cytochalasin B, microtubules and metabolic inhibitors, and decreased only with temperature. Our data demonstrate that hormonal secretion by hyperactive thyroids is not secondary to apical phagocytosis of colloid droplets.
D000818:Animals; D003571:Cytochalasin B / Q000494:pharmacology; D004285:Dogs; D006980:Hyperthyroidism / Q000139:chemically induced*; D066298:In Vitro Techniques; D007457:Iodine Radioisotopes; D013696:Temperature; D013961:Thyroid Gland / Q000648:ultrastructure; D013972:Thyrotropin / Q000037:antagonists & inhibitors / Q000494:pharmacology
D007457:Iodine Radioisotopes; D003571:Cytochalasin B; D013972:Thyrotropin
La sécrétion thyroïdienne dans l'hyperplasie expérimentale.