[Insulin secretion in alcoholic hepatopathy: analysis by measurement of C-peptide (author's transl)].
Basal and reactive peripheral hyperinsulinism recorded in alcoholic hepatic disease may result from decreased hepatic breakdown or pancreatic hypersecretion. C-peptide (CPR) and insulin (IRI) concentrations were measured in 3 groups of 8 alcoholic patients--steatosis, compensated and decompensated cirrhosis--and compared with 8 normal subjects in order to determine the importance of these two possibilities. At basal state, the molar ratio CPR/IRI was near the normal (8.7 +/- 0.9) but is diminished in the 8 hyperinsulinaemic patients (5.9 +/- 0.6). After i.v. glucose tolerance test and tolbutamide stimulations, an hyperreactivity of IRI and CPR may be noted in cirrhotics. A relative insensitivity of the B-cell to glucose appeared after comparison with the effect of tolbutamide. Thus basal hyperinsulinism resulted of decreased hepatic breakdown and stimulated hyperinsulinism resulted of hypersecretion. Glucose intolerance and anomalies of the insulin secretion were more apparent with severe hepatic disease.
D000293:Adolescent; D000328:Adult; D002096:C-Peptide / Q000097:blood*; D005235:Fatty Liver, Alcoholic / Q000097:blood*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D006946:Hyperinsulinism / Q000209:etiology; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D008104:Liver Cirrhosis, Alcoholic / Q000097:blood* / Q000150:complications; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000097:blood*; D014044:Tolbutamide
D002096:C-Peptide; D007328:Insulin; D010455:Peptides; D014044:Tolbutamide
Analyse de l'insulinosécrétion par le dosage du peptide C au cours des hépatopathies alcooliques.