A clinical trial of indomethacin and ibuprofen in dysmenorrhea.
Forty patients with primary dysmenorrhea were treated with antiprostaglandin agents. Seventeen were treated with indomethacin, with 71% obtaining significant relief. Of 23 treated with ibuprofen, 87% obtained significant relief. Nausea occurred in 49%, vomiting in 23% and stool frequency in 35%. All of these gastro-intestinal symptoms were relieved by both drugs. Ibuprofen was free of side effects, but four patients had headaches or peculiar psychic effects on indomethacin.
D000293:Adolescent; D000328:Adult; D004412:Dysmenorrhea / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000627:therapeutic use*; D007213:Indomethacin / Q000009:adverse effects / Q000627:therapeutic use*
D007052:Ibuprofen; D007213:Indomethacin