title: The influence of increased dietary linoleate on essential hypertension in man.
abstract: A pilot study testing the hypothesis of a blood pressure lowering effect of polyunsaturated fatty acids was conducted in Evans County, Georgia. A moderate increase of dietary linoleic acid significantly decreased diastolic blood pressure in eight borderline hypertensives who were otherwise healthy, within four weeks. The change was not due to a reduced sodium content of the diet. A significant increase in creatinine excretion and clearance was noted, indicating an improvement in kidney function which might explain the blood pressure lowering effect of the fat-modified diet.
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D004041:Dietary Fats; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000503:physiopathology* / Q000652:urine; D008041:Linoleic Acids; D008297:Male
chemical_list: D004041:Dietary Fats; D008041:Linoleic Acids