title: Comparative electron microscopic study of clear cells in epidermodysplasia verruciformis and flat warts.
abstract: Are Epidermodysplasia verruciformis (E.V.) and disseminated flat warts different diseases? Are there any diagnostic criteria between them? In order to attempt answering these 2 questions, fundamental for prognosis and nosology, a comparative ultrastructural study was made of epidermal clear cells of 2 cases of E.V. and 4 flat warts from 4 patients of whom 3 were under immunosuppression drugs. The reason of cytoplasmic electron translucency was mainly a reduction in tonofilaments and keratohyalin amounts in E.V. and a centrifugal edema and vacuolization in flat warts. On the other hand, the number of ribosomes was raised in E.V. and reduced in flat warts. These findings allow differentiation between the 2 diseases and suggest a possible different host-virus relationship.
mesh_terms: D000328:Adult; D003593:Cytoplasm / Q000648:ultrastructure; D006801:Humans; D007181:Inclusion Bodies, Viral / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D009506:Nevus / Q000235:genetics / Q000648:ultrastructure*; D011230:Precancerous Conditions / Q000235:genetics / Q000648:ultrastructure*; D012871:Skin Diseases / Q000473:pathology*; D012878:Skin Neoplasms / Q000235:genetics / Q000648:ultrastructure; D013577:Syndrome; D014860:Warts / Q000473:pathology*