title: Effect of lipid load and carbon tetrachloride on the fatty acid release from dog adipose tissue isolated in vivo.
abstract: Under the influence of lipid emulsion (LipofundinR) administered into the systemic circulation of dogs, fatty acid release of adipose tissue isolated in vivo increased from 0.51 +/- 0.096 muEq/100 g/min to 3.18 +/- 0.48 muEq/100 g/min. If the lipid emulsion had been injected into the artery of adipose tissue, the fatty acid release was elevated from 0.34 +/- 0.053 muEq/100 g/min to 1.67 +/- 0.25 muEq/100 g/min. The effect could be observed in denervated adipose tissue too and in this case the fatty acid release increased from 0.40 +/- 0.053 muEq/100 g/min to 1.16 +/- 0.14 muEq/100 g/min. If CCl4 dissolved in lipid emulsion was injected into the systemic circulation, there was no significant change and a value of 0.45 +/- 0.063 muEq/100 g/min was measured. However, on administering the CCl4 dissolved in LipofundinR into the artery of adipose tissue, the fatty acid release rose from 0.34 +/- 0.053 to 1.01 +/- 0.18 muEq/100 g/min. The same manipulation on denervated adipose tissue elevated the fatty acid release from 0.40 +/- 0.053 to 0.96 +/- 0.16 muEq/100 g/min.
mesh_terms: D000273:Adipose Tissue / Q000098:blood supply / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000378:metabolism*; D004285:Dogs; D005217:Fat Emulsions, Intravenous / Q000494:pharmacology*; D005230:Fatty Acids, Nonesterified / Q000097:blood / Q000378:metabolism*; D005260:Female; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D005217:Fat Emulsions, Intravenous; D005230:Fatty Acids, Nonesterified