Peptides in Parkinson's disease.
Peptides have found a progressively more important role in the biochemistry and physiology of the brain in recent years. Many possess neurological and behavioral actions in addition to their function in endocrinology. This paper reviews the formation and distribution, as well as the neurological action, of peptides probably involved in Parkinson's disease: beta-LPH and its derivatives (MSH, ACTH4-10, beta-endorphin). It also recounts the experience of many authors with prolyl-leucyl-glycine-amide (PLG) in that disease. Finally we propose a new theory of the etiology of Parkinson's disease, based on a postulated deficiency in the important trophic function upon catecholaminergic neurons of A.P.U.D. cells.
D001921:Brain / Q000378:metabolism*; D004723:Endorphins / Q000378:metabolism; D006801:Humans; D009074:Melanocyte-Stimulating Hormones / Q000378:metabolism; D010300:Parkinson Disease / Q000209:etiology / Q000378:metabolism*; D010455:Peptides / Q000378:metabolism*; D008083:beta-Lipotropin / Q000378:metabolism
D004723:Endorphins; D010455:Peptides; D009074:Melanocyte-Stimulating Hormones; D008083:beta-Lipotropin