title: Beta-chain variants in Jamaican newborns.
abstract: In an electrophoretic study of 15,661 Jamaican cord bloods, 8 rare beta-chain variants were found in 18 subjects in addition to the common beta-chain variants, Hb S and Hb C. The heterozygote frequencies for Hb S and Hb C were 10.1% and 3.7% respectively. The most frequent of the rare beta-chain variants were Hb Korle Bu (beta 73 Asp leads to Asn) (7 cases) and Hb O su-Christiansborg (beta 52 Asp leads to Asn) (3 cases). One new beta-chain variant, Hb Caribbean (beta 91 Leu leads to Arg) was found.
mesh_terms: D002852:Chromatography, Ion Exchange; D004592:Electrophoresis, Starch Gel; D005260:Female; D005312:Fetal Blood; D014644:Genetic Variation; D006446:Hemoglobin E / Q000235:genetics; D006451:Hemoglobin, Sickle / Q000235:genetics; D006455:Hemoglobins, Abnormal / Q000235:genetics*; D006801:Humans; D007231:Infant, Newborn; D007563:Jamaica; D008297:Male
chemical_list: D006451:Hemoglobin, Sickle; D006455:Hemoglobins, Abnormal; D006446:Hemoglobin E