Calcium oxalate stone disease: effects and side effects of cellulose phosphate and succinate in long-term treatment of absorptive hypercalciuria or hyperoxaluria.
Absorptive hypercalciuria was treated in 27 patients with cellulose phosphate. In all patients urinary calcium decreased and stone formation virtually ceased. The most striking side effect was an excessive hyperoxaluria, necessitating withdrawal of the drug in 8 patients. Succinate decreased the hyperoxaluria in 14 of 19 patients. All patients had mild hypercalciuria and hypermagnesiuria. This study was done to determine the therapeutic value and the side effects in the treatment of absorptive hypercalciuria with sodium cellulose phosphate and of hyperoxaluria with succinate.
D000328:Adult; D000368:Aged; D002118:Calcium / Q000652:urine*; D002411:Cation Exchange Resins / Q000627:therapeutic use*; D002482:Cellulose / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D007475:Ion Exchange Resins / Q000627:therapeutic use*; D007669:Kidney Calculi / Q000188:drug therapy* / Q000652:urine; D008297:Male; D008875:Middle Aged; D009943:Organophosphorus Compounds / Q000627:therapeutic use; D010070:Oxalates / Q000652:urine*; D013386:Succinates / Q000627:therapeutic use*
D002411:Cation Exchange Resins; D007475:Ion Exchange Resins; D009943:Organophosphorus Compounds; D010070:Oxalates; D013386:Succinates; D002482:Cellulose; C008881:phosphocellulose; D002118:Calcium