Modelling the cell-mediated immunity in homograft refection.
Lymphocytes which become sensitised at the periphery travel to the regional lymph nodes where they initiate an immunological response by increasing the production of immuno-competent lymphocytes. These lymphocytes migrate into the tissues via the blood stream and bring about the destruction of target cells. These notions, in the present analysis, are translated into a simple mathematical model. The model specifically considers the lymphocyte memory and increased secondary response.
D003201:Computers; D006084:Graft Rejection; D006789:Host vs Graft Reaction; D007111:Immunity, Cellular; D008198:Lymph Nodes / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D008954:Models, Biological; D013997:Time Factors; D014184:Transplantation, Homologous