Endocrinological and physiological features after steroid treatment of male rats.
The effects of medroxyprogesterone acetate (Provera), testosterone propionate (TP), ethinyl estradiol (EE), and ethynodiol diacetate (ED) treatments on sperm population in different segments of the male rat reproductive tract, reproductive organ weights, circulating androgens and fertility were studied. Ten microgram TP given for five days reduced the sperm population and organ weights. A marked reduction in the number of sperm and reproductive organ weights was observed in males orally treated with estrogens. Only long-term (20 days) treatment with Provera (1 mg/day) significantly reduced sperm population and reproductive organ weights. Combination of TP and Provera resulted in a more pronounced reduction in sperm counts and organ weights. Among steroids studied, estrogen was the only compound which suppressed fertility and circulating steroid levels.
D000728:Androgens / Q000097:blood; D000818:Animals; D002452:Cell Count; D004822:Epididymis / Q000033:anatomy & histology; D004997:Ethinyl Estradiol / Q000494:pharmacology*; D005040:Ethynodiol Diacetate / Q000494:pharmacology*; D005298:Fertility / Q000187:drug effects; D005837:Genitalia, Male / Q000033:anatomy & histology / Q000187:drug effects*; D007989:Libido / Q000187:drug effects; D008297:Male; D008525:Medroxyprogesterone / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D011467:Prostate / Q000033:anatomy & histology; D051381:Rats; D012669:Seminal Vesicles / Q000033:anatomy & histology; D013091:Spermatogenesis / Q000187:drug effects*; D013094:Spermatozoa / Q000166:cytology; D013737:Testis / Q000032:analysis; D013739:Testosterone / Q000494:pharmacology*
D000728:Androgens; D013739:Testosterone; D004997:Ethinyl Estradiol; D005040:Ethynodiol Diacetate; D008525:Medroxyprogesterone