The effect of new furanochrome derivatives on circulatory system and respiratory activity of experimental animals.
Six new compounds of furanochromone group were tested for their acute toxicity (LD50), the effect on arterial blood pressure, respiratory activity of the cat, the effect on ECG and antiarrhythmic activity. All compounds produce a moderate hypotension. Protection against BaCl2-induced arrhythmia is offered by hydrochlorides of N-2-morpholino-etyl ester of alpha-2-methyl-8-methoxyfurano (3', 2' :6,7)-chromonoxy-5-butyric acid, 3, and of N, N-diethylaminoethyl ester of alpha-2-methyl-8-methoxyfurano-(3', 2' : 6,7)-chromonoxy-5-propionic acid, 4. These compounds show the weakest hypotensive activity. The most potent hypotensive action is produced by hydrochlorides of N,N-diethylaminoethyl ester of alpha-2-methyl-8-methoxyfurano (3', 2' : 6,7)-chromonoxy-5-butyric acid 1, and of N-/2-piperidinoethyl ester of alpha-2-methyl-8-methoxyfurano(3', 2' : 6,7)-chromonoxy-5-propionic acid, 5, (short-lasting action).
D000818:Animals; D000889:Anti-Arrhythmia Agents; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D002867:Chromones / Q000494:pharmacology* / Q000633:toxicity; D004562:Electrocardiography; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D007928:Lethal Dose 50; D008297:Male; D051381:Rats; D012119:Respiration / Q000187:drug effects*
D000889:Anti-Arrhythmia Agents; D002867:Chromones