A light and electron microscopic study of the neuropathy of equine idiopathic laryngeal hemiplegia.
A study has been made of the pathological changes in the recurrent laryngeal nerves from horses with clinical and sub-clinical idiopathic laryngeal hemiplegia. Qualitative and quantitative studies showed in clinical cases there was a progressive distal loss of large myelinated fibres in the left recurrent nerve. Regenerating clusters and onion bulbs were frequently seen in affected nerves both at proximal and distal levels. Degenerating axons were characterized by collections of organelles, and denervated bands of Bungner were common. Similar but less severe changes were seen in the left recurrent nerve of sub-clinical cases, and in both the clinical and sub-clinical cases the distal right recurrent nerve was also affected. Teased fibre studies showed evidence of chronic demyelination and remyelination. The aetiology of this chronic neuropathy remains uncertain but the possibility of nerve compression is discussed.
D000818:Animals; D002452:Cell Count; D006734:Horse Diseases / Q000473:pathology*; D006736:Horses; D007823:Laryngeal Nerves / Q000473:pathology*; D008854:Microscopy, Electron; D009186:Myelin Sheath / Q000473:pathology; D009410:Nerve Degeneration; D009413:Nerve Fibers, Myelinated; D012009:Recurrent Laryngeal Nerve / Q000473:pathology*; D014826:Vocal Cord Paralysis / Q000473:pathology / Q000662:veterinary*