Thymus morphology in NZB mice after multiple dosage with somatotropin.
Cortical matter increased in the thymus after ten-day dosage of Coombs-positive NZB mice with somatotropin and thyroxine; cortical matter predominated over medullar matter. Secondary lymphoid follicles disappeared and the number of mast and plasma cells decreased. With administration of the hormone, rosette-forming cells began to appear in the thymus.
D000818:Animals; D013006:Growth Hormone / Q000494:pharmacology*; D008214:Lymphocytes / Q000187:drug effects; D051379:Mice; D008814:Mice, Inbred NZB / Q000276:immunology*; D012397:Rosette Formation; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects*; D013974:Thyroxine / Q000494:pharmacology
D013006:Growth Hormone; D013974:Thyroxine