Biogenic amine response to whole body irradiation. Prevention by APTH.
60Co whole body irradiation with 154.8 mC/kg (600 R) resulted in a mortality of 50 per cent within two weeks. Administration of 1-acetyl-3-phenylamidine thiocarbamide hydrochloride (APTH) 30 min before irradiation prevented this mortality. Irradiation eliminated neurosecretory material from the perikaryons of the supraoptic and paraventricular neurons, whereas APTH counteracted this action. APTH also increased the synthesis of bioamines (5-hydroxytryptamine, catecholamine and acetylcholine).
D000109:Acetylcholine / Q000096:biosynthesis / Q000097:blood; D000818:Animals; D001679:Biogenic Amines / Q000096:biosynthesis*; D001921:Brain / Q000378:metabolism* / Q000528:radiation effects; D002395:Catecholamines / Q000096:biosynthesis; D002802:Cholinesterases / Q000097:blood; D003037:Cobalt Radioisotopes; D007031:Hypothalamus / Q000528:radiation effects; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000188:drug therapy / Q000201:enzymology / Q000378:metabolism*; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D051381:Rats; D012701:Serotonin / Q000096:biosynthesis; D013859:Thiocarbamates / Q000627:therapeutic use*
D001679:Biogenic Amines; D002395:Catecholamines; D003037:Cobalt Radioisotopes; D011837:Radiation-Protective Agents; D013859:Thiocarbamates; D012701:Serotonin; D002802:Cholinesterases; D000109:Acetylcholine