[Lysozyme activity (LZM) and unsaturated vitamin B-12-binding capacity (NZW vit B-12) in the serum following prednisone administration in patients with bone marrow aplasia with pancotypenia].
In 18 patients with bone marrow aplasia with pancytopenia lysozyme activity and unsaturated vitamin B12-binding capacity in the serum were determined. These investigations, together with determinations of peripheral blood polymorphonuclear count, were done again after prednisone administration. In all cases a significant fall was found in the NZW vit B12 and LZM activity in the serum. A slight rise in the polymorphonuclear count in the 24th hour of the study was associated with a rise in the NZW wit. B12 in the serum, and decreased LZM activity. This confirmed the previously demonstrated complex character of corticosteroid action on the system of polymorphonuclears. These results point also to the usefulness of determination of unsaturated vitamin B12-binding capacity for evaluating the value of the total granulocyte pool in granulocytopenia.
D000328:Adult; D000368:Aged; D000741:Anemia, Aplastic / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009113:Muramidase / Q000097:blood*; D010198:Pancytopenia / Q000188:drug therapy*; D011241:Prednisone / Q000494:pharmacology* / Q000627:therapeutic use; D014805:Vitamin B 12 / Q000097:blood*
D009113:Muramidase; D014805:Vitamin B 12; D011241:Prednisone
Zachowanie sie aktywności lizozymu (LZM) i nienasyconej zdolności wiazania witaminy B12 (NZW wit. B12) w surowicy pod wpływem prednisonu u chorych z aplazja szpiku z pancytopenia.