The effect of some anti-diarrhoeal drugs on intestinal transit and faecal excretion of water and electrolytes in the horse.
The effect of morphine, Tinct. opii, loperamide, pethidine and atropine on intestinal transit and the faecal and urinary excretion of water and electrolytes was studied in ponies. The rate of passage of a particulate marker was slowed by morphine, hastened then slowed by loperamide and Tinct. opii, and hastened by atropine. The liquid marker was slowed by Tinct. opii and hastened then slowed by the other drugs. Only loperamide decreased the faecal sodium excretion. This drug also decreased faecal water and weight; it appeared worthy of clinical trial in diarrhoea. Tinct. opii decreased by morphine, pethidine and atropine increased faecal water.
D000818:Animals; D000930:Antidiarrheals / Q000494:pharmacology*; D001285:Atropine / Q000494:pharmacology; D004573:Electrolytes / Q000032:analysis* / Q000652:urine; D005243:Feces / Q000032:analysis*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006736:Horses / Q000378:metabolism* / Q000502:physiology; D008139:Loperamide / Q000494:pharmacology; D008297:Male; D008614:Meperidine / Q000494:pharmacology; D009020:Morphine / Q000494:pharmacology; D009892:Opium / Q000494:pharmacology; D014867:Water / Q000032:analysis*
D000930:Antidiarrheals; D004573:Electrolytes; D014867:Water; D008139:Loperamide; D009020:Morphine; D001285:Atropine; D009892:Opium; D008614:Meperidine