Electroretinography in pigmented rats with tapeto-retinal degeneration.
We studied tapeto-retinal degeneration in the offspring of Royal College of Surgeons (RCS) and Wistar albino rats. Normal ERG values vary according to skin pigmentation: thresholds and implicit times are different. We believe the best experimental material is to be found in the affected pigmented offspring. Evolution of the degeneration over more than 9 months has been observed before extinction and the expressivity of the disease varies from one individual to another. This animal model closely resembles the ERG findings observed clinically in certain pigmentary degenerations of the retina.
D000417:Albinism / Q000235:genetics; D000818:Animals; D003433:Crosses, Genetic; D003623:Dark Adaptation; D004596:Electroretinography; D010375:Pedigree; D051381:Rats; D011919:Rats, Inbred Strains / Q000235:genetics*; D012160:Retina / Q000503:physiopathology*; D012174:Retinitis Pigmentosa / Q000235:genetics / Q000503:physiopathology*; D012880:Skin Pigmentation