The effects of paraquat on prostaglandin synthesis of guinea pig lungs.
The effects of paraquat treatment (10 mg/kg i.p.) on the prostaglandin synthesizing ability of guinea pig lungs were examined in the present study. It was observed that paraquat-treated animals, as compared to controls, had a significantly reduced ability to synthesize PGF2 alpha and "PGE2" at 24 and 48 h after the treatment. Paraquat, however, failed to have any effect on prostaglandin synthesis in vitro. A decrease in the ability of prostaglandin synthesis in paraquat-treated guinea pig lung was attributed possibly to a decrease in the amount of lung microsomal protein.
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008168:Lung / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D008861:Microsomes / Q000378:metabolism; D010269:Paraquat / Q000494:pharmacology*; D011458:Prostaglandins E / Q000096:biosynthesis*; D011460:Prostaglandins F / Q000096:biosynthesis*; D013997:Time Factors
D011458:Prostaglandins E; D011460:Prostaglandins F; D003577:Cytochrome P-450 Enzyme System; D010269:Paraquat