[Effect of Freund's complete adjuvant on the catecholamine content in the adrenals and brain of white rats].
The authors studied the effect of a single subcutaneous injection of 0.3 ml of complete Freund's adjuvant on catecholamine content in the adrenal glands and the brain of Wistar rats. There proved to be a sharp reduction of adrenaline and noradrenaline content per gm of adrenal gland raw tissue, and per one adrenal gland at periods of from 1 to 5 weeks after the adjuvant administration, and also a loss of the adrenal gland weight. A less pronounced, but significant increase in the noradrenaline and DOPA concentration was revealed in the brain tissue during the first week after the adjuvant administration, and, of dopamine at all the periods of study. It is suggested that both the peripheral and central links of the sympathoadrenal system were activated by the nonspecific stimulant.
D000311:Adrenal Glands / Q000032:analysis / Q000187:drug effects*; D000818:Animals; D001921:Brain / Q000187:drug effects*; D001923:Brain Chemistry; D002395:Catecholamines / Q000032:analysis*; D005620:Freund's Adjuvant / Q000494:pharmacology*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D013997:Time Factors
D002395:Catecholamines; D005620:Freund's Adjuvant
Vliianie polnogo ad"iuvanta Freĭnda na soderzhanie katekholaminov v nadpochechnikakh i mozge belykh krys.