[The antisteatosic activity of 2-MPG (Thiola). Study with the (BSF) dynamic test and with liver biopsy before and after the treatment].
The short-term therapeutic effect of 2-MPG has been studied in 12 patients suffering from chronic liver disease of prevalent steatosic type. The drug was administered in a dose of 2.5 g. for 20 days. Patients were submitted to hepatic needle biopsy and BSF load test, with compartmental analysis before and after treatment. A marked reduction in steatosis and a statistically significant fall in BSF retention at the 45th minute, with increase in conjugation and excretion of colorant, was observed in 11 patients.
D000328:Adult; D000368:Aged; D000603:Amino Acids, Sulfur / Q000627:therapeutic use*; D002908:Chronic Disease; D004341:Drug Evaluation; D005234:Fatty Liver / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology / Q000503:physiopathology; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D013448:Sulfobromophthalein; D008625:Tiopronin / Q000008:administration & dosage / Q000627:therapeutic use*
D000603:Amino Acids, Sulfur; D013448:Sulfobromophthalein; D008625:Tiopronin
Sull'attività antisteatosica della 2-MPG (Thiola). Studio con prova dinamica (BSF) e con biopsia epatica prima e dopo il trattamento.