Effects of X-rays on cell membranes. I. Changes of membrane potential of L-cells.
Changes in the membrane potential of cultured L-929lcells were investigated after irradiation with doses ranging from 5-200 Gy. Immediately after irradiation a depolarisation is observed that is followed by a damped oscillation of the membrane potential and finally by a rapprochement to the control value. Whereas the magnitude of depolarisation does not show any dependence on irradiation dose, the time required to reach the control value again increases with increasing dose. Up to 10 Gy, the period of the first half-oscillation rises rapidly to about 12 min, at higher doses a slow linear increase follows reaching a value of 23 min after 200 Gy.
D002462:Cell Membrane / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D007739:L Cells; D008564:Membrane Potentials / Q000528:radiation effects*; D013696:Temperature; D013997:Time Factors; D014965:X-Rays