Immunosuppressive effect of concanavalin-A. II. In vivo suppression of cytotoxic lymphocytes generation in alloimmunized mice.
An examination was carried out of the in vivo effect of Concanavalin-A (Con-A) on the induction of secondary cytotoxic response (CL) to allogeneic spleen cells in mice. CL responses were suppressed by one i.v. injection of 200 micrograms of Con-A one day before first or second immunization or two i.v. injections of Con-A, 200 micrograms each, given simultaneously with immunization. Single dose of 200 microgram of Con-A given simultaneously inhibited anamnestic CL response only partially, to the range observed in the primary response.
D000818:Animals; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology*; D003602:Cytotoxicity, Immunologic / Q000187:drug effects*; D006649:Histocompatibility Antigens; D007156:Immunologic Memory / Q000187:drug effects*; D007165:Immunosuppression Therapy; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology*; D008297:Male; D051379:Mice; D013154:Spleen / Q000276:immunology
D006649:Histocompatibility Antigens; D003208:Concanavalin A