Extrapolation to man of pharmacological results obtained on animals.
Drug development relies on the assumption of a high degree of correlation between the effects of drugs in animals and man. While a good correlation exists as far as the pharmacodynamic action of the drug is concerned it is usually the unpredictable pharmacokinetic properties of the drug responsible for obscuring proper correlations.
D000818:Animals; D000830:Animals, Laboratory; D004353:Drug Evaluation, Preclinical / Q000662:veterinary; D010600:Pharmacology; D013045:Species Specificity