Equillibrium disorders with diffuse brain atrophy in long-term toluene sniffing.
A Japanese male who became habituated to sniffing toluene exhibited ataxia, tremor, incoordination and equilibrium disorders. There was pendular nystagmus with a normal caloric response. There were an inhibition of optokinetic nystagmus and a failure to follow over 0.1 Hz sine waves on eye tracking test. Angiogram and pneumoencephalogram revealed an atrophy of the midbrain and cerebrum, and degeneration of the cerebellum was suspected.
D000328:Adult; D001284:Atrophy; D001921:Brain / Q000473:pathology; D001927:Brain Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging; D002533:Cerebral Angiography; D002908:Chronic Disease; D006801:Humans; D008297:Male; D011011:Pneumoencephalography; D004856:Postural Balance / Q000187:drug effects*; D019966:Substance-Related Disorders / Q000150:complications*; D014050:Toluene / Q000009:adverse effects*
D014050:Toluene