An experimental approach to the optimum oestrogen dosage in prostatic carcinoma.
The action of diethylstilboestrol on the androgen response mechanism of the human prostate has been examined. A simple in vitro test system that assesses effects on hormone uptake, receptor binding and translocation to the nucleus has been employed. The test has also been modified to study the effect of diethylstilboestrol on the activity of 5 alpha-reductase, the enzyme responsible for the conversion of testosterone to 5 alpha-dihydrotestosterone. These results are discussed in relation to the dosage of diethylstilboestrol for treatment of carcinoma of the prostate.
D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism; D004054:Diethylstilbestrol / Q000008:administration & dosage / Q000378:metabolism*; D013196:Dihydrotestosterone / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D011467:Prostate / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D011944:Receptors, Androgen / Q000187:drug effects
D011944:Receptors, Androgen; D013196:Dihydrotestosterone; D004054:Diethylstilbestrol; D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase