Effect of zinc on leucocyte sodium transport in vitro.
1. In a preparation of human leucocytes maintained in tissue culture fluid, increasing the extracellular zinc concentration leads to a significant increase in both ouabain-sensitive sodium efflux and in sodium influx. 2. Cell water and sodium content do not alter significantly with increasing extracellular zinc concentration. 3. A small increase in the ouabain-insensitive sodium efflux can be demonstrated when the external zinc concentration is raised from 0.75 mumol/l to 90 mumol/l.
D001693:Biological Transport, Active / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D007962:Leukocytes / Q000187:drug effects / Q000378:metabolism*; D012964:Sodium / Q000097:blood*; D015032:Zinc / Q000494:pharmacology*
D012964:Sodium; D015032:Zinc