title: [Heteropolycyclic systems. VI. 4-Propyl-2,3,3a,4-tetrahydro-1H-pyrrolo(2,1c)(1,2,4)benzothiadiazine-5,5-dioxide and its derivatives. Cardiovascular effects of 4-alkyltetrahydropyrrolobenzothiadiazine in the anesthetized rat].
abstract: A series of 4-propylderivatives of 2,3,3a,4-tetrahydro-1H-pyrrolo[2,1-c] [1,2,4]benzothiadizine-5,5-dioxide substituted or unsubstituted in the benzene ring was synthesized. Derivatives of these compounds together with those of the corresponding 4-methyl and 4-ethyl derivatives prepared previously were tested for cardiovascular effects in the anesthesized rat. All the compounds studied showed hypotensive activity which was particularly intense for compounds (X), (XIX), (XXII), (XXV), and produced an increase in differential pressure marked for (XXV) and (XXVIII) which was often accompanied by pronounced bradycardia (XVII), (XVIII) and (XIX). The results prove that derivatives of 2,3,3a,4-tetrahydro-1H-pyrrolo-[2,1-c][1,2,4]benzothiadiazine-5,5-dioxide have hypotensive and bradycardizing activity. Structure-activity relationships are discussed.
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D051381:Rats; D013329:Structure-Activity Relationship; D013829:Thiadiazines / Q000138:chemical synthesis / Q000494:pharmacology*; D013843:Thiazines / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D013829:Thiadiazines; D013843:Thiazines
vernacular_title: Sistemi eteropoliciclici. Nota VI - 4-Propil-2,3,3a,4-tetraidro-1H-pirrolo[2,1-c][1,2,4]benzotiadiazin-5,5-diossido e suoi derivati. Effetti cardiovascolari delle 4-alchiltetraidropirrolbenzotiadiazine nel ratto anestetizzato.