title: The stimulatory effect of human PMNI lysosomes on lymphocytes in vitro and in vivo.
abstract: The proteins isolated from human PMNL lysosome granules have activated the lymphocytes in vitro. It was found that T cells undergo transformation in response to lysosome mitogens but no LIF production was observed. Transformation induced by PHA, PWM and Con A was depressed in the presence of lysosome mitogens. The in vivo response to T-dependent antigens is amplified by lysosome mitogens. The above experiments demonstrate that lysosome mitogens stimulate T lymphocytes.
mesh_terms: D000818:Animals; D000917:Antibody Formation; D006168:Guinea Pigs; D006801:Humans; D037102:Lectins / Q000494:pharmacology; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D008222:Lymphokines / Q000096:biosynthesis; D008247:Lysosomes / Q000201:enzymology / Q000502:physiology; D051379:Mice; D009504:Neutrophils / Q000276:immunology* / Q000648:ultrastructure; D010447:Peptide Hydrolases / Q000378:metabolism
chemical_list: D037102:Lectins; D008222:Lymphokines; D010447:Peptide Hydrolases