[Influence of digitalis on pindolol activity in exercise-induced cardiac failure in patients with coronary disease (author's transl)].
The activity of the beta-receptor blocker pindolol (0.4 mg i.v.) was investigated alone and in combination with digitalis (moderately fast loading) in 12 patients with coronary heart disease and without manifest signs of cardiac insufficiency. These patients showed pathological increase of left ventricular filling pressure during exercise testing. The exercise-induced rise of the mean pulmonary arterial and capillary pressures were increased by pindolol. Concurrently the increase of cardiac frequency was clearly diminished during ergometry (from 107/min without pindolol to 96/min, P less than 0.005). Digoxin given orally for an average of 5 days prevented the pressure increase in the pulmonary circulation induced by pindolol during exercise testing and at rest. The frequency reducing effect of pindolol was potentiated by digitalis. Use of digitalis alone did not influence mean exercise-induced pressure increase of the pulmonary circulation. In fact in some cases deterioration of these parameters was observed.
D000113:Acetyldigoxins / Q000494:pharmacology* / Q000627:therapeutic use; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D002196:Capillaries; D003327:Coronary Disease / Q000188:drug therapy*; D004077:Digoxin / Q000031:analogs & derivatives*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008168:Lung / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D010869:Pindolol / Q000494:pharmacology / Q000627:therapeutic use*; D011651:Pulmonary Artery
D000113:Acetyldigoxins; D004077:Digoxin; D010869:Pindolol
Einfluss von Digitalis auf die Pindolol-Wirkung bei Koronarkranken mit Belastungsherzinsuffizienz.