title: [Structurally dependent effects of substituted thioureas on rna phage m 12 (author's transl)].
abstract: Using the agar diffusion method, thiourea as well as N-aryl-, N, N'-diaryl-, N-aryl-N'-alkyl-, N,N'-dialkyl-, and N-alkyl-substituted thiourea derivatives were examined for their effects on the system of Escherichia coli W 1665 F+/M 12. The compounds tested were found to produce more or less strongly inhibitive or promotive effects on the RNA phages and/or host bacteria. N-phenyl-N'-dibutyl thiourea, N-phenyl-N'-acetyl thiuorea, and N1,N1'-p-phenylene-bis-(N3-n-propyl thiourea) showed an intense inhibitory effect on M12. Quite obviously, the decisive intervention by these substances in the multiplication of viruses was by a replicative step subsequent to the adsorption of phages.
mesh_terms: D003090:Coliphages / Q000187:drug effects*; D008968:Molecular Conformation; D013890:Thiourea / Q000031:analogs & derivatives / Q000494:pharmacology*
chemical_list: D013890:Thiourea
vernacular_title: Die strukturabhängige Wirkung substituierter Thioharnstoffe auf den RNA-Phagen M 12.