[Acrylonitrile stimulation of lipid peroxidation in rat liver].
Acrylonitrile stimulated slightly the lipid peroxidation in isolated microsomes and exhibited distinct prooxidative effect in postmitochondrial supernatant, containing microsomes and cell juice. Acrylonitrile did not form a complex with cytochrome P-450, possessing distinct spectral properties of the I or II types, and did not stimulate the oxygen utilization by microsomes in presence of NADPH. The hepatotoxic effect of acrylonitrile appears to be due to its property to stimulate the formation of lipid peroxides in hepatocytes.
D000181:Acrylonitrile / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D001665:Binding Sites; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D005231:Fatty Acids, Unsaturated / Q000378:metabolism*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism*; D009570:Nitriles / Q000494:pharmacology*; D010084:Oxidation-Reduction / Q000187:drug effects; D010545:Peroxides / Q000096:biosynthesis; D051381:Rats; D013347:Subcellular Fractions / Q000378:metabolism
D005231:Fatty Acids, Unsaturated; D009570:Nitriles; D010545:Peroxides; D003577:Cytochrome P-450 Enzyme System; D000181:Acrylonitrile
Stimuliatsiia akrilonitrilom perekisnogo okisleniia lipidov v pecheni krys.