Autophagy in mouse hepatocytes induced by lysine acetylsalicylate.
I.v. administration of lysine acetylsalicylate inces autophagy in mouse liver cells. Single and multiple membrane-bounded vacuoles were found. The latter seems to be an unusual morphological form of the sequestration process. These findings could express a transitory sublethal liver cell injury induced by the drug.
D000818:Animals; D001241:Aspirin / Q000031:analogs & derivatives* / Q000494:pharmacology; D001343:Autophagy / Q000187:drug effects*; D005260:Female; D008099:Liver / Q000187:drug effects* / Q000648:ultrastructure; D008239:Lysine / Q000031:analogs & derivatives* / Q000494:pharmacology; D051379:Mice; D010587:Phagocytosis / Q000187:drug effects*; D014617:Vacuoles / Q000187:drug effects
D008239:Lysine; D001241:Aspirin; C010395:acetylsalicylic acid lysinate