title: Urinary kallikrein excretion and plasma DBH activity in hypertension.
abstract: Many factors are to be considered in maintaining normal blood pressure. Authors study the behavior of urinary kallikrein (U.K.) and plasma dopamine-beta-hydroxylase (DBH) activity in various forms of hypertension. The values of U.K. excretion in normals were 20.5 +/- 1.8 E.U./24 h. In essential hypertensive patients (9.4 +/- 2.0 E.U./24 h) U.K. decreased, while in secondary hypertension it was significantly higher (33.8 +/- 3.0 E.U./24 h). Plasma DBH activity in essential hypertensive patients (17.72 +/- 2.33 I.U./ml) was similar to controls (20.22 +/- 1.39 I.U./ml); in secondary hypertension the mean values of plasma DBH were decreased (12.31 +/- 2.55 I.U./ml). No correlation between U.K. and plasma DBH activity was observed in normals and in various forms of hypertensive patients. U.K. seems a more reliable factor than plasma DBH in defining the different types of hypertension.
mesh_terms: D000293:Adolescent; D000328:Adult; D004299:Dopamine beta-Hydroxylase / Q000097:blood*; D006801:Humans; D006973:Hypertension / Q000378:metabolism*; D007610:Kallikreins / Q000652:urine*; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D012016:Reference Values
chemical_list: D004299:Dopamine beta-Hydroxylase; D007610:Kallikreins