Inhibition by adenosine of thyroidal T4 release in vitro.
Adenosine, like catecholamines, inhibits the thyroidal T4 release in vitro, when stimulated by TSH,N,O'-dibutyryl cyclic AMP [(Bu) 2cAMP], and phosphodiesterase inhibitors. Unlike catecholamines, the adenosine-induced inhibition is independent of adrenergic receptors. It is postulated that TSH stimulates thyroidal T4 release through a cAMP activated, adenosine-sensitive, protein kinase.
D000241:Adenosine / Q000494:pharmacology*; D000818:Animals; D006151:Guanosine / Q000494:pharmacology; D007288:Inosine / Q000494:pharmacology; D051379:Mice; D013961:Thyroid Gland / Q000187:drug effects / Q000378:metabolism*; D013972:Thyrotropin / Q000494:pharmacology; D013974:Thyroxine / Q000378:metabolism*
D006151:Guanosine; D007288:Inosine; D013972:Thyrotropin; D000241:Adenosine; D013974:Thyroxine