[Effect of omega-H-perfluorinated carbonic acids on the wet weight, membrane potential and contractility of isolated skeletal muscle].
To investigate the effect of fluoralkanes on cellular functions, isolated frog muscles were exposed to octafluoro-pentanoic acid (OP) and hexadecafluoro-nonanoic acid (HN). 20 MM of OP induced a small depression of the contraction amplitude and a loss of wet weight of 10% which was similar to the osmotic effect of pentanoic acid or sucrose. The membrane resting potential was not changed up to 50 mM. HN was much more effective: 0,5 mM decreased the contraction amplitude in a few minutes and depolarized the membrane by 20 to 30 mV in 2 h. 10 mM HN induced a weight gain of 20% connected with a contracture. Since the caffeine contracture was also depressed by 1 mM it is assumed that HN interact with cellular membranes and alter their Ca-binding properties.
D000818:Animals; D001001:Anura; D005466:Fluorocarbons / Q000633:toxicity*; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects; D009132:Muscles / Q000187:drug effects* / Q000502:physiology; D009929:Organ Size / Q000187:drug effects
D005466:Fluorocarbons; C018959:hexadecafluoro-nonanoic acid
Zur Wirkung omega-H-perfluorierter Karbonsäuren auf Frischgewicht, Membranpotential und Kontraktionsverhalten isolierter Skeletmuskeln.