[Participation of glutamate and alanine in amino acid biosynthesis, in lipogenesis, and in gluconeogenesis in the brain].
The participation of glutamate and alanine in lipogenesis and gluconeogenesis of brain was investigated. 5(14)C glutamate was injected intracisternally in an amount of 5 mcCu/l g tissue and 3(14)C-alanine was injected subcutaneously 30 mcCu/100 g body weight. Labels from glutamate and alanine were recovered in different lipid franctions -- in phospholipids, glycerides, free fatty acids and cholesterol, as well as in glucose and glycogen. An intensive incorporation of label from 5(14)C glutamate into various amino acids--aspartic acid, glutamine, serine, glycine and alanine--was demonstrated. The data presented indicate the participation of amino acids in lipogenesis and gluconeogenesis of brain.
D000409:Alanine / Q000378:metabolism*; D000596:Amino Acids / Q000096:biosynthesis*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002951:Citrates / Q000096:biosynthesis; D005227:Fatty Acids / Q000096:biosynthesis; D005943:Gluconeogenesis; D005971:Glutamates / Q000378:metabolism*; D007656:Ketoglutaric Acids / Q000378:metabolism; D008055:Lipids / Q000096:biosynthesis*; D051381:Rats
D000596:Amino Acids; D002951:Citrates; D005227:Fatty Acids; D005971:Glutamates; D007656:Ketoglutaric Acids; D008055:Lipids; D000409:Alanine
Uchastie glutamata i alanina v biosinteze aminokislot, v lipogeneze i gliukoneogeneze golovnogo mozga.