title: Molecular connectivity study of halocarbon anesthetics.
abstract: The structure--activity relationships of 45 halogenated hydrocarbons using molecular connectivity were studied. A very good correlation was obtained between the anesthetic activity and the molecular connectivity term o chi v in addition to the polar hydrogen factor, QH. The equation reported accounts for the quantifies the known structure--activity observations on general anesthetics. The results are discussed briefly with reference to the mechanisms of action of general anesthetics.
mesh_terms: D000777:Anesthetics; D006846:Hydrocarbons, Halogenated / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000777:Anesthetics; D006846:Hydrocarbons, Halogenated