Pathophysiology and management of acute gastric mucosal hemorrhage.
Unlike hemorrhage from peptic ulcer, surgical management for hemorrhage from stress ulcer is not necessarily successful on many occasions. Thus, the most important thing one can try is to prevent the development of this condition. Forty eight patients admitted to the Shock and Trauma Unit, Hahnemann Medical College and Hospital, who had a primary diagnosis of shock were divided into three groups: group 1 received the standard shock regimen plus large dose steroid therapy repeated every four hours for 36 hours; group 2 received the standard shock regimen plus small dose steroid therapy repeated every four hours for 96 hours; group 3 received the standard shock regimen without the addition of steroids. There was a 57.9 per cent incidence of acute gastric ulceration in those shock patients not treated with steroids (group 3) compared with 33.3 per cent incidence of gastric ulceration in group 2 and 5.9 per cent incidence in group 1. The use of pharmacologic doses of steroids early in the shock state for period of less than 36 hours seems to reduce the incidence of gastric ulceration and hemorrhage in low flow states associated with septic, cardiogenic and hemorrhagic shock.
D000208:Acute Disease; D000818:Animals; D002927:Cimetidine / Q000627:therapeutic use; D004285:Dogs; D005753:Gastric Mucosa; D006801:Humans; D010437:Peptic Ulcer / Q000517:prevention & control; D010438:Peptic Ulcer Hemorrhage / Q000503:physiopathology / Q000517:prevention & control / Q000628:therapy*; D011458:Prostaglandins E / Q000627:therapeutic use; D051381:Rats; D012774:Shock, Traumatic / Q000628:therapy; D013256:Steroids / Q000627:therapeutic use; D013312:Stress, Physiological / Q000188:drug therapy
D011458:Prostaglandins E; D013256:Steroids; D002927:Cimetidine