C1q-binding substances in peripheral lymph in bronchial carcinoma.
Peripheral leg lymph has been studied for the presence of C1q-binding substances by the I-C1q binding radioassay in six male patients with untreated bronchial carcinoma. In serum, this assay is highly specific for antigen-antibody complexes (immune complexes). Three of the patients had immune complexes in serum, and they all also had C1q-binding substances in peripheral lymph. The C1q-binding activity was quite similar in serum and peripheral lymph. In the other three patients, immune complexes were not found in serum, but in ome of them, moderate amounts of C1q-binding substances were found in peripheral lymph. The results suggest that immune complexes may be found in peripheral lymph in cancer patients in about the same amounts as in serum. However, formal proof is lacking that the C1q-binding substances of peripheral lymph are real immune complexes.
D000936:Antigen-Antibody Complex; D001984:Bronchial Neoplasms / Q000097:blood / Q000276:immunology*; D003172:Complement C1 / Q000378:metabolism*; D006801:Humans; D008196:Lymph / Q000276:immunology*; D008297:Male; D011863:Radioimmunoassay
D000936:Antigen-Antibody Complex; D003172:Complement C1