Inhibition of the local Shwartzman reaction by turpentine, prostaglandin E2 and carbon tetrachloride.
The conventional local Shwartzman reaction (LSR) did not occur in rabbits whose plasma haptoglobin (Hp) was lowered by treatment with carbon tetrachloride, nor in animals in whom Hp was elevated after treatment with turpentine, or PGE2 or endotoxin. The possible mechanisms of such inhibition of the LSR are discussed.
D000818:Animals; D002251:Carbon Tetrachloride / Q000494:pharmacology*; D004731:Endotoxins / Q000494:pharmacology; D006242:Haptoglobins; D011817:Rabbits; D012790:Shwartzman Phenomenon / Q000097:blood*; D014425:Turpentine / Q000494:pharmacology*
D004731:Endotoxins; D006242:Haptoglobins; D002251:Carbon Tetrachloride; D014425:Turpentine