title: [Nutritional and toxicological impacts of administered inorganic tin for six months in rats (author's transl)].
abstract: An experimentation  of intoxication by stannous chloride has been realized in the rat. Two groups of animals have been fed ad libitum, during six months, with a diet containing respectively 0,4 and 0,8 g of tin (SnCl2) for 100 g of dry food. By gamma radioactivity measurements (with 113Sn used as a tracer), it results that this metal does not practically clear the digestive barrier. All the treated animals are characterized by a ponderal evolution obviously lower than temoins. At the end of treatment, tin entails a significative diminution of hematocrit, hemoglobin and serous iron, particularly at the highest dose studied. The essential impact remains that tin induces a total irritation of gastro-intestinal tract, proved by histological investigations.
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004032:Diet; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D013997:Time Factors; D014001:Tin / Q000633:toxicity*
chemical_list: D014001:Tin
vernacular_title: Impacts nutritionnels et toxicologiques de l'étain inorganique administré pendant 6 mois chez le rat.