Vasovasostomy and vas occlusion: preliminary observations using artificial devices in guinea pigs.
Intravas devices designed to reverse a vasectomy or to occlude the vasa instead of transecting them were evaluated in guinea pigs. Absorbable intravas devices (AID) were inserted into the vasa at the time of vasovasostomy and produced a return of normal semen quality in 73% of the experimental animals as compared with only 40% in the control group. Seventy per cent of the AID group sired litters. In a second group of guinea pigs, vasectomy was replaced by the bilateral insertion of reversible intravas plugs (RIP) which occluded the lumina. After a period of azoospermia, the central, occlusive pins were removed from the devices. Sperm-positive animals were bred and three of five sired normal offspring. Histologic examination of the vasa revealed morphologic changes in some AID animals, these being attributed to the vasectomy procedure. A similar evaluation of the functional RIP insertion site revealed the desired occlusive tissue-device interfaces.
D000818:Animals; D006168:Guinea Pigs; D008297:Male; D009845:Oligospermia / Q000473:pathology; D013243:Sterilization Reversal / Q000295:instrumentation* / Q000379:methods; D013245:Sterilization, Reproductive / Q000295:instrumentation* / Q000379:methods; D014649:Vas Deferens / Q000473:pathology