Fluorinated phenytoin anticonvulsant analogs.
Six ring-fluorinated phenytoin analogs were synthesized, and their anticonvulsant activity in the maximal electroshock seizure and subcutaneous pentylenetetrazol assays was determined. 5-(4-Fluorophenyl)-5-phenylhydantoin, 5-(3-fluorophenyl)-5-phenylhydantoin, and 5,5-bis(4-fluorophenyl)hydantoin were active in the maximal electroshock seizure assay. The compounds were much less potent than phenytoin but showed an extremely long duration of action.
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis*; D004597:Electroshock; D008297:Male; D008722:Methods; D051379:Mice; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D010672:Phenytoin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D004856:Postural Balance / Q000187:drug effects; D013329:Structure-Activity Relationship; D013997:Time Factors
D000927:Anticonvulsants; D010672:Phenytoin; D010433:Pentylenetetrazole