[Improvement of the oxygen supply of the cirrhotic rat liver by selection of portacaval shunt method].
Intrahepatic disturbances of circulation following various portasystemic shunting procedures can be monitored by means of the Pt-multiwire surface electorde. The normal liver is capable of compensating for each degree of portal blood deprivation. In the presence of a thioacetamide-induced liver cirrhosis in the rat a side-to-side PCS significantly improves oxygen supply of the liver. Preserving residual portal perfusion of the liver by choice of different portasystemic shunts, the oxygen supply is slightly improved, too. This effect does not correlate with the quantity of residual liver perfusion, but is possibly due to vasocative hormonal substances, from a pancreatico-duodenal source, that regualte liver circulation.
D000818:Animals; D008099:Liver / Q000378:metabolism*; D008102:Liver Circulation; D008103:Liver Cirrhosis / Q000378:metabolism / Q000601:surgery*; D008297:Male; D008642:Mesenteric Veins / Q000601:surgery; D010101:Oxygen Consumption; D010313:Partial Pressure; D011167:Portacaval Shunt, Surgical / Q000379:methods*; D051381:Rats; D013162:Splenic Vein / Q000601:surgery
Verbesserung der Sauerstoffversorgung der cirrhotischen Rattenleber durch Wahl der portocavalen Shuntform.