Serum concentrations of orally administered diphenylhydantoin in dogs.
Diphenylhydantoin was found to have a short half life and poor gastrointestinal absorption in dogs. Consequently, serum content after single or repeated oral dosage of 10 mg/kg of body weight did not exceed a concentration of 2 microgram/ml. To achieve a postulated effective plasma concentration of diphenylhydantoin, oral dosage of at least 35 mg/kg of body weight 3 times daily seems necessary.
D000284:Administration, Oral; D000818:Animals; D004285:Dogs / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D010672:Phenytoin / Q000008:administration & dosage* / Q000097:blood
D010672:Phenytoin