Inhibition of plasminogen activator production in organ cultures by cycloheximide.
The production of tissue plasminogen activator (TPA) in rat tongue organ cultures is strongly inhibitied by low concentrations of the protein synthesis inhibitor cycloheximide. TPA production is fully resumed after the removal of cycloheximide from the culture medium.
D003513:Cycloheximide / Q000494:pharmacology*; D003864:Depression, Chemical; D009924:Organ Culture Techniques; D010960:Plasminogen Activators / Q000096:biosynthesis*; D014059:Tongue / Q000378:metabolism
D003513:Cycloheximide; D010960:Plasminogen Activators