[Oxidation of some substrates in the presence of NAD(P)-dependent oxidoreductases and 4-anilino-5-methoxybenzoquinone-1,2 with transfer of reducing equivalents to oxygen].
A reaction sequence for oxidation of L-lactate, ethanol, D-glucose-6-phosphate, and isocytrate by oxygen in the presence of NAD(P)-dependent oxidoreductases and 4-anilino-5-methoxybenzoquinone-1,2 was studied. A complete reaction sequence includes (1) oxidoreduction of a corresponding substrate with a specific NAD(P)-dependent dehydrogenase and formation of NAD(P)H (2) reduction of AMOBQ, AMOBQHa formation in the oxidoreduction of NAD(P)H and AMOBQ, catalized by menadione reructase (EC 1.6.99.2); (3) oxygen reduction with AMOBQH2 in a spontaneous or enzymic reaction. AMOBQ plays a catalytic role in the transfer of reducing equivalents to oxygen in the above--menshioned systems. Possible biochemical mechanism for aminoaromatic ortho-benzoquinone derivatives is discussed.
D000429:Alcohol Oxidoreductases / Q000378:metabolism*; D002384:Catalysis; D010084:Oxidation-Reduction; D010100:Oxygen; D011808:Quinone Reductases / Q000378:metabolism; D011809:Quinones / Q000378:metabolism*
D011809:Quinones; D000429:Alcohol Oxidoreductases; D011808:Quinone Reductases; D010100:Oxygen
Okislenie nekotorykh substratov pri uchastii NAD(P)-zavisimykh oksidoreduktaz n 4-anilino-5-metoksi-1,2-benzokhinona s perenosom vosstanovitel'nykh ekvivalentov na kislorod.