The structural events associated with the attachment of complement components to cell membranes in reactive lysis.
Electron microscopic study of the events occurring at the cell membrane during reactive lysis by complement, showed that a foliaceous particle was formed at the C5b-7 stage, that enlarged to a particle with a variable number of arms at the C5b-8 stage. Up to this point, no typical complement lesions were found. At the C5b-9 stages, the particles were completely converted to typical complement lesions, i.e. hollow cylinders projecting from the cell membrane and partly penetrating it. C5b-9 complexes assembled in the fluid phase did not show the typical structure of the lesions, but were amorphous masses of fibres.
D003182:Complement C5 / Q000276:immunology; D003183:Complement C6 / Q000276:immunology; D003184:Complement C7 / Q000276:immunology; D003185:Complement C8 / Q000276:immunology; D003186:Complement C9 / Q000276:immunology; D003165:Complement System Proteins / Q000276:immunology*; D004910:Erythrocyte Membrane / Q000276:immunology / Q000648:ultrastructure*; D004912:Erythrocytes / Q000648:ultrastructure*; D006461:Hemolysis; D006801:Humans; D008854:Microscopy, Electron
D003182:Complement C5; D003183:Complement C6; D003184:Complement C7; D003185:Complement C8; D003186:Complement C9; D003165:Complement System Proteins