Prolactin and growth hormone releasing activity of [D-Met2, Pro5]-enkephalinamide in the rat after systemic administration.
The growth hormone (GH) and prolactin releasing (PRL) activity of [D-Met2, Pro5]-enkephalinamide (EKNH2). an opioid peptide analog with higher opiate agonist activity that morphine, was compared in the unanesthetized male rat to those of equimolar doses of morphine upon systemic injection. EKNH2 proved to be a higher PRL, but not GH, releaser than the opiate alkaloid.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004723:Endorphins / Q000494:pharmacology*; D004745:Enkephalins / Q000008:administration & dosage / Q000494:pharmacology*; D013006:Growth Hormone / Q000097:blood*; D007275:Injections, Intravenous; D008297:Male; D009020:Morphine / Q000494:pharmacology; D011388:Prolactin / Q000097:blood*; D051381:Rats
D004723:Endorphins; D004745:Enkephalins; D009020:Morphine; D011388:Prolactin; D013006:Growth Hormone