[Experimental studies on the affinity of Toxoplasma gondii to various organs of mice (author's transl)].
In response to their alleged "uterus affinity" the organotropism of various Toxoplasma strains was investigated in the female mouse. Using quantitative histological (immunofluorescence) and serological (Sabin-Feldman-dye test, complement fixation test), we examined the brain, heart, lung, spleen, striated muscle, uterus and ovaries. The following results were obtained: All four of the Toxoplasma strains (ALT, DX, WEISS, GAIL) showed a definite neurotropism. Located in the brain were one hundred times as many cysts as in the sexual organs and ten times as many as in the reamining organs. The uterus and ovary show a low susceptibility, invasion rarely occuring. An "uterus affinity" could not be confirmed. All four Toxoplasma strains showed the same affinity for the various organs. The strain ALT showed the most virulence and formed the most cysts.
D000818:Animals; D001921:Brain / Q000469:parasitology*; D005260:Female; D006321:Heart / Q000469:parasitology; D008168:Lung / Q000469:parasitology; D051379:Mice; D009132:Muscles / Q000469:parasitology; D010053:Ovary / Q000469:parasitology; D013154:Spleen / Q000469:parasitology; D014122:Toxoplasma / Q000302:isolation & purification*; D014774:Virulence
Tierexperimentelle Untersuchungen zur Organaffinität von Toxoplasma gondii.