Endothelial injury by nicotine and its prevention.
Nicotine administered i.v. or p.o. in doses above 0.0125 mg/kg to the rat caused a highly significant increase in circulating anuclear carcasses of endothelial cells estimated by an original method. This effect of nicotine was completely prevented by a prior oral administration of the flavonoids hydroxyethylrutosides (HR) or Mono-7-HR.
D000818:Animals; D001808:Blood Vessels / Q000187:drug effects*; D004727:Endothelium / Q000166:cytology / Q000187:drug effects; D005260:Female; D006896:Hydroxyethylrutoside / Q000031:analogs & derivatives / Q000494:pharmacology; D009538:Nicotine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats
D006896:Hydroxyethylrutoside; D009538:Nicotine