[Interaction of calcium and some neuropharmacological agents on the isolated nerve fiber].
It has been suggested that calcium interferes with the effect of the local anesthetics (Blaustein and Goldman, 1966). Experiments were therefore made with the anionic phenobarbital and the cationic procaine and chlorpromazine in high (18 mM/1) and in low (0,18 mM/1) calcium concentration. These experiments showed that the effect of drugs used, and of changes in calcium concentration were independent of each other.
D000818:Animals; D001001:Anura; D002118:Calcium / Q000494:pharmacology*; D002746:Chlorpromazine / Q000494:pharmacology*; D004347:Drug Interactions; D009412:Nerve Fibers / Q000187:drug effects*; D010634:Phenobarbital / Q000494:pharmacology*; D011188:Potassium / Q000494:pharmacology; D011343:Procaine / Q000494:pharmacology*; D011898:Ranidae; D012584:Sciatic Nerve / Q000187:drug effects; D012964:Sodium / Q000494:pharmacology
D011343:Procaine; D012964:Sodium; D011188:Potassium; D002118:Calcium; D002746:Chlorpromazine; D010634:Phenobarbital
Interazione fra calcio e alcuni neurofarmaci sulla fibra nervosa isolata.