Hemoglobin variants in India.
The occurrence of different types of hemoglobin variants in India has been well-documented in urban populations and in certain tribal areas. Beta-thalassaemia and hemoglobins D,E,H,S, and rare variants like Hb Lepore, have been found in varying percentages. There is a higher incidence of Hb E in the Eastern region and of Hb D in certain Northern populations. The association of Hb E with beta thalassaemia G6PD deficiency has been established. The relationship with other environmental factors, like malaria, is not yet clear.
D004777:Environment; D005544:Forecasting; D014644:Genetic Variation; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000453:epidemiology; D006446:Hemoglobin E / Q000235:genetics; D006447:Hemoglobin H / Q000235:genetics; D006451:Hemoglobin, Sickle / Q000235:genetics; D006455:Hemoglobins, Abnormal / Q000235:genetics*; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D007194:India; D008288:Malaria / Q000097:blood; D010641:Phenotype; D012424:Rural Population; D013789:Thalassemia / Q000453:epidemiology
D006451:Hemoglobin, Sickle; D006455:Hemoglobins, Abnormal; D006446:Hemoglobin E; D006447:Hemoglobin H