Chemoneurolysis of the canine gastric submucosa. Effects on Heidenhain pouch secretion.
Double denervated gastric pouches were constructed in dogs. One gastric pouch served as a control, and the other gastric pouch had its submucosa infiltrated with 25% ethyl alcohol (submucosal chemoneurolysis). Neurolysis of these gastric pouches did not alter their histological appearance but did eliminate their gastric secretory responses to histamine, meat and pentagastrin. The dogs exhibited elevated serum gastrin levels after feeding.
D000818:Animals; D003714:Denervation / Q000379:methods; D004285:Dogs; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D005502:Food; D005750:Gastric Juice / Q000187:drug effects / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D006632:Histamine / Q000494:pharmacology; D008297:Male; D010418:Pentagastrin / Q000494:pharmacology; D013270:Stomach / Q000187:drug effects / Q000294:innervation / Q000502:physiology*
D000431:Ethanol; D006632:Histamine; D010418:Pentagastrin