title: [Effects of the organophosphorus insecticide Ofunack on the metabolism of cells cultured in vitro].
abstract: The effects of "ofunack (0,0-diethyl-0-(3-oxo-2-phenyl-2H-pyridazine-6-y1) phosphorothionate on the metabolism of IB-RS-2 cell line were studied. "Ofunack" stimulates cell growth and protein synthesis till 24 hours after its addition to the maintenance medium. Otherwise after this time "ofunack" induces an inhibition both on cell growth and on protein synthesis. This insecticide also inhibits the synthesis of RNA and DNA.
mesh_terms: D000818:Animals; D002460:Cell Line; D002478:Cells, Cultured / Q000187:drug effects* / Q000378:metabolism; D004247:DNA / Q000096:biosynthesis; D066298:In Vitro Techniques; D007306:Insecticides / Q000494:pharmacology*; D007668:Kidney; D009946:Organothiophosphorus Compounds; D014176:Protein Biosynthesis; D011724:Pyridazines / Q000494:pharmacology; D012313:RNA / Q000096:biosynthesis; D013552:Swine
chemical_list: D007306:Insecticides; D009946:Organothiophosphorus Compounds; D011724:Pyridazines; D012313:RNA; D004247:DNA
vernacular_title: Efeitos do inseticida fosforado, "ofunack" sobre o metabolismo de células cultivadas "in vitro".