title: Lack of effect of morphine and buprenorphine on hypoxic pulmonary vasoconstriction in the isolated perfused cat lung and the perfused lobe of the dog lung.
abstract: In an isolated perfused cat lung preparation and a perfused lobe of dog lung preparation a pressor response of the pulmonary circulation was elicited to alveolar hypoxia (5% oxygen). The magnitude of this reponse was not affected by either of the opioid drugs, morphine or buprenorphine.
mesh_terms: D000818:Animals; D002047:Buprenorphine / Q000494:pharmacology*; D002415:Cats; D004285:Dogs; D000860:Hypoxia / Q000503:physiopathology*; D066298:In Vitro Techniques; D008168:Lung; D009019:Morphinans / Q000494:pharmacology*; D009020:Morphine / Q000494:pharmacology*; D010477:Perfusion; D011652:Pulmonary Circulation / Q000187:drug effects*; D014661:Vasoconstriction / Q000187:drug effects*
chemical_list: D009019:Morphinans; D002047:Buprenorphine; D009020:Morphine