[Peculiarities of alkyl tin effects on respiration and oxidative phosphorylation of rat liver mitochondria].
Electron transfer and oxidative phosphorylation were studied as affected by tinalkyls. It is shown that all of them inhibit effectively respiration of the rat liver mitochondria. The action of bis(tributyl tin)oxide and dibutyl diisooctyl thioglycolate tin on the mitochondria in a state of dissociation is localized in the terminal step of the respiration chain. The other alkyls act in the site located before cytocrome c. The effect of bis (tributyl tin) oxide on both the ADP-activated respiration and DNP-activated ATPase of intact mitochondria is similar to that of oligomycin. These effects might be explained by the presence two electrophilic centres in a molecule of this compound.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D004140:Dinitrophenols / Q000494:pharmacology; D004579:Electron Transport / Q000187:drug effects; D066298:In Vitro Techniques; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D009840:Oligomycins / Q000494:pharmacology; D009947:Organotin Compounds / Q000494:pharmacology*; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D014220:Trialkyltin Compounds / Q000494:pharmacology
D004140:Dinitrophenols; D009840:Oligomycins; D009947:Organotin Compounds; D014220:Trialkyltin Compounds; C005961:bis(tri-n-butyltin)oxide; D000244:Adenosine Diphosphate
Osobennosti deĭstviia olovoalkilov na dykhanie i okislitel'noe fosforilirovanie mitokhondriĭ pecheni krys.