Stereoselectivity of oxotremorine antagonists containing a chiral pyrrolidine group.
Oxotremorine (Ia) and its succinimide analogue (IIa) have been substituted in the pyrrolidine ring with a methyl group in the 2- or 3-positions. The compounds are oxotremorine antagonists. The 2-methyl-substituted enantiomers show stereoselectivity, the S-isomers being the most active.
D000818:Animals; D001681:Biological Assay; D051379:Mice; D010095:Oxotremorine / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors*; D011759:Pyrrolidines; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D011759:Pyrrolidines; D010095:Oxotremorine