title: [Alteration of TSH secretion in children with goitre after short-term treatment with potassium iodide (author's transl)].
abstract: 300 microgram of potassium iodide daily were administered over a period of two weeks to 12 children with goitre. Basal TSH concentrations, maximal TSH increase after TRH and integrated TSH secretion after TRH were significantly decreased in this group whereas the increase of total thyroxine (T4-RIA) did not reach significance. It appears that in the development of iodine deficiency goitre in children a sensitive feed-back system is predominant. Early administration of iodine or even better general iodinated salt prophylaxis seem to be the pathogenetically correct approach in solving the common goitre problem.
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005246:Feedback; D005260:Female; D006042:Goiter / Q000188:drug therapy*; D006801:Humans; D008297:Male; D011193:Potassium Iodide / Q000008:administration & dosage / Q000627:therapeutic use*; D013972:Thyrotropin / Q000097:blood / Q000378:metabolism*; D013974:Thyroxine / Q000097:blood; D013997:Time Factors
chemical_list: D011193:Potassium Iodide; D013972:Thyrotropin; D013974:Thyroxine
vernacular_title: Veränderungen der TSH-Sekretion bei Kindern mit Strumen nach Kurzzeitbehandlung mit Kaliumjodid.