title: Improvement in the yield of oral poliovirus vaccine (Sabin strains) produced in human diploid cells.
abstract: When stationary cultures of human diploid cells in conventional Roux bottles were replaced by the development of cells in roller bottles, the yield of poliovirus, Sabin strains type 1 and 2, showed an increase of 0.5 to 1 log10. No significant difference was noticed in the yield of these viruses cultured in WI-38 and MRC-5 human diploid cells.
mesh_terms: D002478:Cells, Cultured; D004171:Diploidy; D006801:Humans; D011055:Poliovirus Vaccine, Oral / Q000592:standards; D013696:Temperature; D013997:Time Factors; D014776:Virus Cultivation / Q000379:methods*
chemical_list: D011055:Poliovirus Vaccine, Oral