The occurrence of an inhibitor of Ca2+-dependent neutral protease in rat liver.
The occurrence of a novel and specific inhibitor of Ca2+-dependent neutral protease in rat liver has been demonstrated. The partially purified product is a heat-stable and acid-stable protein of an approximate molecular weight of 3x10(5), and readily inactivated by tryptic digestion. The inhibition of Ca2+-dependent protease is not a result of the binding of Ca2+ by the inhibitor.
D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D007700:Kinetics; D008099:Liver / Q000201:enzymology*; D008970:Molecular Weight; D010447:Peptide Hydrolases / Q000378:metabolism*; D011506:Proteins / Q000302:isolation & purification / Q000502:physiology*; D051381:Rats
D011506:Proteins; D010447:Peptide Hydrolases; D002118:Calcium