The effect of allopurinol on urinary oxalate excretion in stone formers.
Allopurinol is a drug which could be valuable in the treatment of stone patients. In 29 subjects treated with 300 mg of the drug per day it has been found that there was a significant fall in urine oxalate excretion if the blood urate was above 330 mumol/l. In 10 subjects followed for 1 year the urine oxalate was significantly reduced and maintained at a lower level than the original.
D000493:Allopurinol / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010070:Oxalates / Q000652:urine*; D014527:Uric Acid / Q000097:blood; D014545:Urinary Calculi / Q000188:drug therapy* / Q000652:urine
D010070:Oxalates; D014527:Uric Acid; D000493:Allopurinol