Cancerostatica. II. Synthesis and preliminary cytostatic screening of some alpha-carboline derivatives.
6-Phenyl-and (6-pyridyl-3')-2-chloro-3-aminopyridines were transformed by treatment with HNO3 into the corresponding pyrido [4,5-b] triazoles [7,8]. In PPA medium at 180 degrees, triazoles 7 and 8 decompose to 2-substituted alpha-carbolines 9,10 and anilino-3-hydroxypyridines 11, 12. Some of these compounds showed significant cytostatic activity against transplanted Ehrlich ascites carcinoma and Nemeth-Kellner lymphoma.
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D002243:Carbolines / Q000138:chemical synthesis* / Q000494:pharmacology; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D007211:Indoles / Q000138:chemical synthesis*; D008223:Lymphoma / Q000188:drug therapy; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy
D000970:Antineoplastic Agents; D002243:Carbolines; D007211:Indoles