Reduction of granulosa cell progesterone secretion in vitro by intraovarian implants of antiandrogen.
Intra-ovarian Silastic implants containing the antiandrogen, Flutamide, or its active metabolite, reduced the level of progesterone secretion in porcine granulosa cell cultures by approximately 50%. These results complement recent observations in vitro suggesting a role for androgen in granulosa cell steroidogenesis during follicular development.
D000813:Anilides / Q000494:pharmacology*; D000818:Animals; D004343:Drug Implants; D005260:Female; D005485:Flutamide / Q000031:analogs & derivatives / Q000494:pharmacology*; D006107:Granulosa Cells / Q000187:drug effects / Q000502:physiology*; D010053:Ovary; D011374:Progesterone / Q000378:metabolism*; D013552:Swine
D000813:Anilides; D004343:Drug Implants; D011374:Progesterone; D005485:Flutamide