Systemic lupus erythematosus associated with mixed cryoglobulinaemia and circulating anticoagulant.
We describe a 30-year-old woman with systemic lupus erythematosus (SLE), in whom the only evidence of the disease, during the 10 years before diagnosis was established, was an accelerated erythrocyte sedimentation rate and a positive Wassermann test. Her disease was characterized by the presence of an anticoagulant without indication of bleeding, mixed cryoglobulinaemia, steroid-resistant renal damage, and persistent false-positive tests for syphilis. The relationship between these results and the presence of anticoagulant, mixed cryoglobulinaemia and renal damage in patients with SLE are discussed.
D000328:Adult; D001778:Blood Coagulation Disorders / Q000150:complications; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D010265:Paraproteinemias / Q000150:complications*; D013588:Syphilis Serodiagnosis
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M