Quantitative cisternography.
By quantitative cisternography using a stationary detector system with correction for tissue background, an exponential elimination of 131I-HSA from the basal cisterns was demonstrated, allowing calculation of a biologic half time (BHT) of the clearance curve of a satisfactory level of reproducibility. 'Normal' range of BHT was calculated. Demented patients had significantly longer BHT. In 4 patients with normal pressure hydrocephalus prolonged BHT turned normal after shunting, paralleled by marked clinical improvement, in contrast to previous findings in 4 patients with presenile dementia. The method is now being modified employing 111In-DTPA and a computer assisted gamma camera for regional dynamic analysis.
D000368:Aged; D002552:Cerebral Ventricles / Q000000981:diagnostic imaging*; D003704:Dementia / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D006849:Hydrocephalus / Q000000981:diagnostic imaging*; D006850:Hydrocephalus, Normal Pressure / Q000000981:diagnostic imaging*; D007204:Indium; D008297:Male; D004369:Pentetic Acid; D011868:Radioisotopes; D011877:Radionuclide Imaging; D012709:Serum Albumin; D013667:Technetium; D013997:Time Factors
D011868:Radioisotopes; D012709:Serum Albumin; D007204:Indium; D013667:Technetium; D004369:Pentetic Acid