[Natural plasma inhibitors of factors activated by coagulation. Their behavior under various clinical conditions].
Levels of anti-Xa and anti-thrombin III activity have been determined in a series of patients clinically definable as "thrombophiliac" and of women undergoing oestroprogestinic contraceptive treatment. The levels of plasma Co-Ep activity for potentiating anti-Xa activity on the part of differing in vitro added doses of Ep have also been determined. The fact that anti-Xa fell in more marked a fashion than the corresponding anti-thrombin III may be the humoral equivalent of a condition of plasma hypercoagulability. Treatment with coumarin derivatives may bring about an appreciable increase anti-Xa plasma levels. The significance of these variations is discussed and the sensitivity of the anti-Xa method for monitoring small dose heparin therapy, i.e. based on antithrombotic rather than anti-coagulant effect, is confirmed.
D000328:Adult; D000990:Antithrombin III / Q000378:metabolism / Q000502:physiology; D001777:Blood Coagulation / Q000187:drug effects; D003278:Contraceptives, Oral, Hormonal / Q000009:adverse effects; D003374:Coumarins / Q000494:pharmacology / Q000627:therapeutic use; D005170:Factor X / Q000378:metabolism / Q000502:physiology; D005260:Female; D006493:Heparin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000097:blood / Q000150:complications; D008175:Lung Neoplasms / Q000097:blood / Q000150:complications; D008297:Male; D009203:Myocardial Infarction / Q000097:blood / Q000150:complications; D013927:Thrombosis / Q000097:blood* / Q000188:drug therapy / Q000209:etiology
D003278:Contraceptives, Oral, Hormonal; D003374:Coumarins; D000990:Antithrombin III; D005170:Factor X; D006493:Heparin
Gli inibitori naturali plasmatici dei fattori attivi della coagulazione. Loro comportamento in alcune condizioni cliniche.