Carnitine prevention of adriamycin toxicity in mice.
Carnitine, a naturally occurring nontoxic compound which aids the myocardial cell in efficiently meeting energy requirements, has been evaluated as a possible protective agent against acute and chronic adriamycin induced mouse toxicity. We have shown that carnitine treatment significantly decreases both acute high dose and chronic, intermittent, low dose adriamycin associated lethality in normal mice. These protective effects are accomplished without decreasing adriamycin anti-tumor activity or increasing bone marrow toxicity.
D000818:Animals; D002331:Carnitine / Q000494:pharmacology*; D003114:Colony-Forming Units Assay; D004317:Doxorubicin / Q000037:antagonists & inhibitors* / Q000633:toxicity; D005260:Female; D007942:Leukemia, Experimental / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D013997:Time Factors
D004317:Doxorubicin; D002331:Carnitine