title: Prevention of experimental anaphylactic ulcer by antigen prefeeding.
abstract: Studies were performed in animals to establish whether antigen prefeeding could present homocytotropic antibody synthesis and the induction of gastric ulcer resulting from mucosal anaphylaxis. A single digestive exposure to 1 or 10 mg ovalbumin induced a state of specific immunologic tolerance. Inhibition of the formation of specific reagins was shown by the study of mast cell degranulation. Tolerant animals presented a reduced incidence of gastric ulcer after subsequent mucosal challenge. These results are important for the development of methods of prevention and treatment of allergic diseases.
mesh_terms: D000707:Anaphylaxis; D000818:Animals; D000941:Antigens / Q000008:administration & dosage*; D005260:Female; D005753:Gastric Mucosa / Q000276:immunology*; D007108:Immune Tolerance; D008297:Male; D008407:Mast Cells / Q000276:immunology; D010047:Ovalbumin / Q000008:administration & dosage; D011935:Reagins / Q000096:biosynthesis; D012377:Rodentia; D013276:Stomach Ulcer / Q000276:immunology / Q000517:prevention & control*
chemical_list: D000941:Antigens; D011935:Reagins; D010047:Ovalbumin