Studies of the biochemical pharmacology of the fermentation-derived antitumor agent, (alpha S, 5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125).
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology* / Q000627:therapeutic use; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D005260:Female; D005973:Glutamine / Q000494:pharmacology; D005998:Glycine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity; D007555:Isoxazoles / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D007939:Leukemia L1210 / Q000188:drug therapy / Q000378:metabolism; D007941:Leukemia P388 / Q000378:metabolism; D046911:Macromolecular Substances; D008297:Male; D051379:Mice; D010080:Oxazoles / Q000494:pharmacology*; D012737:Sex Factors; D013936:Thymidine / Q000378:metabolism; D014529:Uridine / Q000378:metabolism; D014633:Valine / Q000378:metabolism
D000903:Antibiotics, Antineoplastic; D007555:Isoxazoles; D046911:Macromolecular Substances; D010080:Oxazoles; D005973:Glutamine; D014633:Valine; D005998:Glycine; D013936:Thymidine; D014529:Uridine