Retinoids induce sister-chromatid exchanges in human diploid fibroblasts.
Vitamin A palmitate, retinoic acid and an aromatic retinoic acid analogue (Ro 10-9359) induced sister-chromatid exchanges (SCE) in human diploid fibroblasts. The same SCE level was reached with the 3 compounds tested, when the concentration of vitamin A palmitate was 10 times higher than those of retinoic acid and Ro 10-9395. No correlation was found when the dose-related SCE induction of a retinoid was compared with the respective antineoplastic activity as reported by others.
D002869:Chromosome Aberrations; D002877:Chromosomes, Human / Q000187:drug effects*; D003434:Crossing Over, Genetic; D005260:Female; D005347:Fibroblasts / Q000648:ultrastructure; D006801:Humans; D008297:Male; D014212:Tretinoin / Q000031:analogs & derivatives / Q000494:pharmacology*; D014801:Vitamin A / Q000031:analogs & derivatives* / Q000494:pharmacology*
D014801:Vitamin A; D014212:Tretinoin