The hypertensive response to injection of physostigmine into the hypothalamus of the unanesthetized rat.
Microinjection of physostigmine (3-30 nmoles) into the posterior hypothalamic nucleus of freely-moving, unanesthetized rats elicited a dose-related hypertensive response. This effect was significantly reduced by prior central injection of hemicholinium-3. The direct acting cholinergic agonist, carbachol, also evoked an elevation of blood pressure following intrahypothalamic injection; however, this response was unaffected by prior administration of hemicholinium-3.
D000109:Acetylcholine / Q000502:physiology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002217:Carbachol / Q000494:pharmacology; D006426:Hemicholinium 3 / Q000494:pharmacology; D006973:Hypertension / Q000139:chemically induced*; D007031:Hypothalamus / Q000187:drug effects / Q000502:physiology*; D007267:Injections; D008297:Male; D010830:Physostigmine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats
D006426:Hemicholinium 3; D002217:Carbachol; D010830:Physostigmine; D000109:Acetylcholine