Factors influencing lipoprotein lipase activity in choline deficiency.
Subcutaneous injections of the lipotropic agent, ethyl trichloracetate, to rats with established choline deficiency raised their plasma triglycerides by 60% and completely removed the hyperglyceridaemic response of Triton WR 1339. The plasma triglyceride levels of choline-supplemented rats were depressed slightly by ethyl trichloracetate administration, which was effective in abolishing response to Triton WR 1339. Lipoprotein lipase activity of epididymal fat pad was stimulated 60% while plasma lipoprotein was not stimulated by ethyl trichloracetate. The increased peripheral removal of low-density lipoprotein-triglyceride complex, allowing greater use to be made of existing apo-proteins, may explain the lipotropic character of the ester.
D000273:Adipose Tissue / Q000201:enzymology; D000818:Animals; D062845:Chloroacetates; D002796:Choline Deficiency / Q000097:blood / Q000201:enzymology*; D008071:Lipoprotein Lipase / Q000097:blood / Q000378:metabolism*; D008297:Male; D011092:Polyethylene Glycols / Q000494:pharmacology; D051381:Rats; D014238:Trichloroacetic Acid / Q000494:pharmacology; D014280:Triglycerides / Q000097:blood
D062845:Chloroacetates; D014280:Triglycerides; D011092:Polyethylene Glycols; D014238:Trichloroacetic Acid; D008071:Lipoprotein Lipase