The renal kallikrein-kinin system in various types of diuresis and under the effects of inhibitors of prostaglandin synthesis in rats.
In rats with water load, rats with high-salt diet, rats treated with furosemide, and rats treated with indomethacin in low doses (2 mg/kg orally per day for five consecutive days) an enhanced urinary excretion of kallikrein was observed. Higher dosage of indomethacin (5 mg/kg), on the contrary, markedly reduced the urinary kallikrein excretion. The degree of activation of the renal kallikrein-kinin system was lowest in water diuresis, and highest at the high-salt diet. In salt- and furosemide-induced diuresis, positive correlations were found between the urinary kallikrein excretion, sodium excretion, urine flow rate, and renal concentration capacity. In water diuresis, a positive correlation was found solely between the kallikrein excretion and the urine flow rate. Indomethacin at low dosages elevated, and at high dosages reduced the activity of the renal kallikrein-kinin system; analogous effects were exerted on the urine flow rate and on sodium excretion.
D000818:Animals; D004231:Diuresis / Q000187:drug effects; D005665:Furosemide / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D007610:Kallikreins / Q000378:metabolism* / Q000652:urine; D007668:Kidney / Q000378:metabolism*; D007671:Kidney Concentrating Ability; D007705:Kinins / Q000378:metabolism*; D008297:Male; D009994:Osmolar Concentration; D011448:Prostaglandin Antagonists / Q000494:pharmacology*; D051381:Rats; D012964:Sodium / Q000652:urine; D012965:Sodium Chloride / Q000494:pharmacology
D007705:Kinins; D011448:Prostaglandin Antagonists; D012965:Sodium Chloride; D005665:Furosemide; D012964:Sodium; D007610:Kallikreins; D007213:Indomethacin