Excretion of methoxyphenamine and its metabolites in rat urine.
Metabolites of methoxyphenamine in urine obtained after oral administration of the drug to rats have been isolated by Sephadex LH-20 column chromatography and identified as the O-, N,O- and N-demethylated derivatives of methoxyphenamine by thin-layer chromatography, spectrometry, and comparisons with synthesized compounds. The unchanged drug and the metabolites excreted in urine have been extracted and determined by gas chromatography after treatment with trifluoroacetic anhydride.
D000284:Administration, Oral; D000818:Animals; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D013058:Mass Spectrometry; D008694:Methamphetamine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000652:urine; D051381:Rats
D008694:Methamphetamine; C005157:methoxyphenamine