Effects of R-28935 on sympathetic nervous activity in anesthetized cat.
Intravenous administration of erythro-1-(1-[2-(1,4-benzodioxan-2-yl)-2-OH-Et]-4-piperidyl)-2-benzimidazolinone (R-28935) (25--100 microgram/kg) produced a dose-related decrease in spontaneous electrical activity recorded in the splanchnic and renal nerves. Reductions in sympathetic nerve activity were paralleled by hypotension and bradycardia. R 28935-induced depressor responses were not affected by baroreceptor denervation, piperoxan, yohimbine or phentolamine. Results support the idea that R-28935 decreased resting blood pressure and heart rate through a reduction in central sympathetic outflow which does not involve alpha-adrenergic receptor activation.
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001562:Benzimidazoles / Q000494:pharmacology*; D002415:Cats; D006321:Heart / Q000294:innervation; D006439:Hemodynamics / Q000187:drug effects; D010646:Phentolamine / Q000494:pharmacology; D010883:Piperoxan / Q000494:pharmacology; D011311:Pressoreceptors / Q000502:physiology; D013564:Sympathetic Nervous System / Q000187:drug effects*; D015016:Yohimbine / Q000494:pharmacology
D000959:Antihypertensive Agents; D001562:Benzimidazoles; D015016:Yohimbine; D010883:Piperoxan; D010646:Phentolamine