title: Prevention of cervical lymphadenitis in guinea pigs by vaccination.
abstract: Cervical lymphadenitis, caused by beta hemolytic Streptococcus of Lancefield's group C, was experimentally produced in guinea pigs. Experimental transmission of cervical lymphadenitis was successful when a scratch in the oral mucous membrane was inoculated with a strain of the causative organism which had been isolated during an epizootic of cervical lymphadenitis. Animals without a mouth lesion did not develop the disease when inoculated in the same manner. Another strain, obtained from the American Type Culture Collection (ATCC-12960) was also used. This latter strain was found to have a low degree of pathogenicity for guinea pigs, and it was used for immunization experiments. Seventy-nine percent of animals inoculated orally with strain 12960 withstood later challenge with the virulent strain, whereas only 5% of the controls withstood the same challenge.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001428:Bacterial Vaccines / Q000008:administration & dosage; D005260:Female; D006168:Guinea Pigs; D008198:Lymph Nodes / Q000382:microbiology; D008199:Lymphadenitis / Q000382:microbiology / Q000517:prevention & control / Q000662:veterinary*; D008297:Male; D009333:Neck; D012376:Rodent Diseases / Q000382:microbiology / Q000517:prevention & control*; D013290:Streptococcal Infections / Q000382:microbiology / Q000517:prevention & control / Q000662:veterinary*; D013291:Streptococcus / Q000276:immunology / Q000302:isolation & purification; D014611:Vaccination / Q000662:veterinary*
chemical_list: D001428:Bacterial Vaccines