Effect of nonsteroidal anti-inflammatory and other pharmacological agents on tuberculin reaction.
Nonsteroidal anti-inflammatory and other pharmacological agents were tested in the efferent arc of the tuberculin skin reaction in the guinea pig. A low but significant inhibition was produced by the acidic anti-inflammatory agents, including the arylalkanoic acids, the anthranilic acids, indomethacin, and phenylbutazone. Some nonacidic anti-inflammatory agents also were inhibitory; benzydamine caused a high inhibition. Except for methotrexate, the antineoplastic--antimetabolite agents were not potent inhibitors. Inhibition without toxicity was produced by the coumarin anticoagulants, the diuretics, chloroquine, tilorone, and the following immunoregulators: antithymocyte gamma-globulin, cyclophosphamide, and penicillamine. Levamisole, colchicine, heparin, and niridazole were inhibitory but produced lethality either at or above the effective dose.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000925:Anticoagulants / Q000494:pharmacology; D000964:Antimetabolites, Antineoplastic / Q000494:pharmacology; D006168:Guinea Pigs; D006632:Histamine; D007111:Immunity, Cellular / Q000187:drug effects*; D008297:Male; D014374:Tuberculin Test; D014425:Turpentine
D000893:Anti-Inflammatory Agents; D000925:Anticoagulants; D000964:Antimetabolites, Antineoplastic; D006632:Histamine; D014425:Turpentine