[Manipulations of immune reactions by antigen-immunosuppressive agent-conjugates. VI. Antigen specific binding of 6-mercaptopurine-protein conjugates by lymphocytes].
The immunologic specificity of 6-mercaptopurin-protein conjugates has been determined by rosette inhibition test using antigen-stimulated lymphocytes and antigen-coated sheep erythrocytes. The specific binding of antigen-immunosuppressive agent-conjugated onto immunocompetent cells is as strong as the binding of the native antigen. The increasing aggregation of the conjugates in consequence of the higher coupling ratio and the thus increased multivalence of the antigen may compensate the effect of antigen determinant loss.
D000818:Animals; D004912:Erythrocytes / Q000276:immunology; D006801:Humans; D007165:Immunosuppression Therapy; D008214:Lymphocytes / Q000276:immunology*; D015122:Mercaptopurine; D012397:Rosette Formation; D012709:Serum Albumin; D012756:Sheep / Q000276:immunology
D012709:Serum Albumin; D015122:Mercaptopurine
Die Beeinflussung von Immunreaktionen durch Antigen-Immunsuppressivum-Konjugate. VI. Antigenspezifische Bindung von 6-Merkaptopurin-Protein-Konjugaten an Lymphozyten.