[Transperitoneal resorption in acute and chronic peritonitis (author's transl)].
Two forms of peritonitis have been examined on 60 rats (Wistar) in three groups. Group 1 = acute peritonitis, group 2 = chronic peritonitis and group 3 = control. All animals have had an injection of an aminoglycosid antibiotic and a proteinase inhibitor into the peritoneal cavity. One intended to measure the influence of the proteinase inhibitor for different kinds of inflammation of the function of resorption of the peritoneum. Serum concentration of the antibiotic after 30, 60, and 90 min was measured. In clinical dosage the resorption of protein-bonded aminoglycosid antibiotics was decreased. The healthy control animals didn't show any effects. Connections concerning molecule size of protein-bonded substances and proteolytic ferments are in discussion. The practical relevance of these results could be found in an retarding effect of the resorption of protein-bonded toxines.
D000208:Acute Disease; D000617:Aminoglycosides / Q000378:metabolism; D000818:Animals; D000900:Anti-Bacterial Agents / Q000378:metabolism; D002908:Chronic Disease; D010537:Peritoneum / Q000378:metabolism*; D010538:Peritonitis / Q000378:metabolism*; D011480:Protease Inhibitors / Q000378:metabolism; D011485:Protein Binding; D051381:Rats
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D011480:Protease Inhibitors
Transperitoneale Resorption des Peritoneums bei der akuten und chronischen Peritonitis. Experimentelle Untersuchungen an der Ratte.