Cross-protective aspects of glucosyltransferase antigens in the hamster caries model.
1) Glucosyltransferase serotypes a and g are closely related antigenically but are more distantly related to GTF of serotype c, based on assays of inhibition of total glucan synthesis. 2) Local immunization with GTF from serotype c S. mutans reduces the colonization, caries, and lesions caused by infection with the homologous strain compared with sham injected controls. 3) Local immunization with GTF of serotype c S. mutans reduces the colonization, caries, and lesions caused by infection with S. mutans of serotype g (strain 6715).
D000818:Animals; D000942:Antigens, Bacterial; D006224:Cricetinae; D003429:Cross Reactions; D003731:Dental Caries / Q000276:immunology* / Q000382:microbiology / Q000517:prevention & control; D005964:Glucosyltransferases / Q000037:antagonists & inhibitors / Q000276:immunology*; D007114:Immunization; D012463:Saliva / Q000276:immunology; D013045:Species Specificity; D013295:Streptococcus mutans / Q000201:enzymology / Q000276:immunology*
D000942:Antigens, Bacterial; D005964:Glucosyltransferases