Effect of lipid load and carbon tetrachloride on the fatty acid release from dog adipose tissue isolated in vivo.
Under the influence of lipid emulsion (LipofundinR) administered into the systemic circulation of dogs, fatty acid release of adipose tissue isolated in vivo increased from 0.51 +/- 0.096 muEq/100 g/min to 3.18 +/- 0.48 muEq/100 g/min. If the lipid emulsion had been injected into the artery of adipose tissue, the fatty acid release was elevated from 0.34 +/- 0.053 muEq/100 g/min to 1.67 +/- 0.25 muEq/100 g/min. The effect could be observed in denervated adipose tissue too and in this case the fatty acid release increased from 0.40 +/- 0.053 muEq/100 g/min to 1.16 +/- 0.14 muEq/100 g/min. If CCl4 dissolved in lipid emulsion was injected into the systemic circulation, there was no significant change and a value of 0.45 +/- 0.063 muEq/100 g/min was measured. However, on administering the CCl4 dissolved in LipofundinR into the artery of adipose tissue, the fatty acid release rose from 0.34 +/- 0.053 to 1.01 +/- 0.18 muEq/100 g/min. The same manipulation on denervated adipose tissue elevated the fatty acid release from 0.40 +/- 0.053 to 0.96 +/- 0.16 muEq/100 g/min.
D000273:Adipose Tissue / Q000098:blood supply / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000378:metabolism*; D004285:Dogs; D005217:Fat Emulsions, Intravenous / Q000494:pharmacology*; D005230:Fatty Acids, Nonesterified / Q000097:blood / Q000378:metabolism*; D005260:Female; D014655:Vascular Resistance / Q000187:drug effects
D005217:Fat Emulsions, Intravenous; D005230:Fatty Acids, Nonesterified