The effect of a single dose of ethanol on pharmacokinetics of paracetamol.
The effect of a single dose of ethanol (200 ml of 20% and 40% solution) on pharmacokinetics of a single dose of paracetamol was tested in healthy men. An open, two-compartment pharmacokinetical model was assumed. Significant changes were observed after 40% ethanol, an increase of AUC, beta, k12, k21, V2 and t1/2 alpha, decrease of Cmax and prolongation of tmax.
D000082:Acetaminophen / Q000378:metabolism*; D000328:Adult; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology*; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D013997:Time Factors
D000082:Acetaminophen; D000431:Ethanol