title: [Determination of the plasma level and excretion to tempidon in man after oral use].
abstract: Tempidone is original Bulgarian preparation, synthetized in NIHFI (Zelayskov Bikova). The plasma level of the preparation is determined after single oral administration in doses of 60 and 120 mg and for a period of five days in a dose of 20 mg three times daily per a person. It is shown that tempidone is quickly resorbed and is excreted unchanged mainly in urine.  The preparation does not cumulate. The content of tempidone in plasma is determined by the method of thin-layer chromatography, but in urine-spectrophotometricaly.
mesh_terms: D000284:Administration, Oral; D001702:Biopharmaceutics; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D006801:Humans; D010880:Piperidines / Q000097:blood*; D010881:Piperidones / Q000008:administration & dosage / Q000097:blood* / Q000378:metabolism; D013997:Time Factors; D014216:Triacetoneamine-N-Oxyl / Q000031:analogs & derivatives
chemical_list: D010880:Piperidines; D010881:Piperidones; D014216:Triacetoneamine-N-Oxyl; C002273:tempidon
vernacular_title: Opredeliane na plazmeno nivo i ekskretsiia na tempidon u khora sled oralno prilozhenie.