New plasmid-mediated phosphorylation of gentamicin C in Staphylococcus aureus.
A clinical isolate of Staphylococcus aureus resistant to gentamicin, kanamycin and 3',4'-dideoxykanamycin B contained two enzymes capable of inactivating gentamicin, i.e., an aminoglycoside 2''-phosphotransferase and aminoglycoside acetyltransferase.
D000123:Acetyltransferases / Q000378:metabolism; D000617:Aminoglycosides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002474:Cell-Free System; D005839:Gentamicins / Q000378:metabolism*; D006801:Humans; D010766:Phosphorylation; D010770:Phosphotransferases / Q000378:metabolism; D011815:R Factors; D013203:Staphylococcal Infections / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000378:metabolism*
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D005839:Gentamicins; D000123:Acetyltransferases; D010770:Phosphotransferases