Pharmacologic enhancement of gallium-67 tumor-to-blood ratios for EMT-6 sarcoma (BALB/c mice).
At various intervals after intravenous injection of carrier-free 67Ga-citrate, iron dextrane or deferoxamine mesylate was injected into EMT-6 tumor-bearing BALB/c mice. After treatment, rapid clearance of 67Ga from soft tissues was observed. Tumor uptake was not greatly affected, and so increased tumor-to-blood ratios were observed. The authors conclude that these drugs can enhance target-to-nontarget uptake ratios for tumors.
D000818:Animals; D003676:Deferoxamine / Q000008:administration & dosage / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D005710:Gallium Radioisotopes / Q000097:blood / Q000378:metabolism; D007505:Iron-Dextran Complex / Q000008:administration & dosage / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D009132:Muscles / Q000378:metabolism; D011877:Radionuclide Imaging; D012513:Sarcoma, Experimental / Q000097:blood / Q000000981:diagnostic imaging* / Q000378:metabolism; D013997:Time Factors; D014018:Tissue Distribution
D005710:Gallium Radioisotopes; D007505:Iron-Dextran Complex; D003676:Deferoxamine