title: Urinary catecholamine excretion and blood sugar response during acute poisonings with dinitrobenzenes.
abstract: Rats were injected intraperitoneally with 0.015 mmol of p-dinitrobenzene/kg, 0.15 mmol of m-dinitrobenzene/kg and 0.45 mmol of o-dinitrobenzene/kg body wt. The dinitrobenzenes induced methaemoglobin concentrations of 86%, 60% and 49%, respectively, as well as increases of urinary catecholamine excretion and blood sugar concentration. Due to hyperglycaemia the glycolysis may be stimulated as mechanism for energy production in methaemoglobin-induced oxygen deficiency and as mechanism for reduction of methaemoglobin, that means as responses favouring survival after poisoning.
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D002395:Catecholamines / Q000652:urine*; D004136:Dinitrobenzenes / Q000008:administration & dosage / Q000506:poisoning*; D005215:Fasting; D007274:Injections, Intraperitoneal; D008297:Male; D008708:Methemoglobinemia / Q000139:chemically induced; D009578:Nitrobenzenes / Q000506:poisoning*; D051381:Rats; D013329:Structure-Activity Relationship; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D002395:Catecholamines; D004136:Dinitrobenzenes; D009578:Nitrobenzenes