Differences in uptake of aminoacids by patients with various forms of cancer.
The serum concentrations of alphaaminonitrogen (AAN), lysine, valine and leucines were determined before and within the period of 24 hr after the administration of Trophysan (10% solution of glucose containing a mixture of aminoacids) in 100 patients with cancer (17 with gastrointestinal carcinoma, 34 with uterus carcinoma, stages I to III; 8 with breast carcinoma, stages II and III; 15 with bronchogenic carcinoma, 10 with various localizations and 15 with metastatic cancer) and in 22 patients with benign tumors. A significant decrease in the serum content of AAN, valine and lysine was noted in patients with cancer (stages I to III) at 24 hours after the administration of Trophysan. This effect was absent for the patients with benign tumors. The enhanced uptake of aminoacids found in patients with cancer is probable the result of the negative nitrogen balance associated with the malignant state.
D000596:Amino Acids / Q000008:administration & dosage / Q000097:blood*; D005260:Female; D006801:Humans; D008239:Lysine / Q000097:blood; D008297:Male; D009362:Neoplasm Metastasis / Q000097:blood; D009369:Neoplasms / Q000097:blood* / Q000175:diagnosis; D014633:Valine / Q000097:blood
D000596:Amino Acids; D014633:Valine; D008239:Lysine