title: Late effects on the eye of conformation radiotherapy for carcinoma of the paranasal sinuses and nasal cavity.
abstract: Sixty patients with carcinoma of the paranasal sinuses and nasal cavity were treated with conformation radiotherapy technique (an improved moving-field technique). Only 28 were suitable for long-term follow-up with regard to eye complications. All patients receiving more than 5,800 rads in 6 weeks (1,700 reu in cumulative-radiation-effect dose) had strong panophthalmia with corneal ulceration within 2 years of radiotherapy. Of 21 eyes receiving 800--1,700 reu (2,800--5,400 rads in 6 weeks), 18 experienced visual disturbance from radiation cataracts and 3 equivocal changes at postirradiation intervals of 5 years. No patient receiving less than 800 reu (2,800 rads in 6 weeks) showed such complications.
mesh_terms: D002386:Cataract / Q000209:etiology*; D004307:Dose-Response Relationship, Radiation; D005500:Follow-Up Studies; D006801:Humans; D007908:Lens, Crystalline / Q000528:radiation effects; D008722:Methods; D009296:Nasal Cavity; D009669:Nose Neoplasms / Q000401:mortality / Q000532:radiotherapy*; D010255:Paranasal Sinus Neoplasms / Q000401:mortality / Q000532:radiotherapy*; D011829:Radiation Dosage; D011832:Radiation Injuries / Q000453:epidemiology*; D011835:Radiation Protection; D011878:Radiotherapy / Q000009:adverse effects*; D013997:Time Factors; D014786:Vision Disorders / Q000209:etiology*