Inhibition of lecithin:cholesterol acyltransferase in human plasma by dicarboxylic lecithins.
The effect of dicarboxylic lecithins on the lecithin:cholesterol acyltransferase [LCAT] activity was studied with a partially purified preparation [approximately 24-fold]. The presence of dicarboxylic lecithins is followed by the inhibition of LCAT. The inhibition is proportional to the concentration of glutaryl-lecithin and is about 50% with 0.16 mM glutaryl-lecithin. For a higher concentration, the inhibition is total. The inhibition of LCAT activity was of a mixed type. It can be explained by a combination of competitive inhibition and interaction of glutaryl-lecithin with phospholipid, which changes the physical properties of lipid, making it less available for conversion into cholesteryl ester.
D006801:Humans; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000037:antagonists & inhibitors / Q000097:blood* / Q000302:isolation & purification; D010713:Phosphatidylcholines / Q000494:pharmacology*; D010767:Phosphorylcholine / Q000138:chemical synthesis
D010713:Phosphatidylcholines; D010767:Phosphorylcholine; D007862:Phosphatidylcholine-Sterol O-Acyltransferase