The use of the rat in the experimental investigation of the porphyrias.
The patterns of urinary porphyria excretion and hepatic porphyrin accumulation in hexachlorobenzene-treated rats is similar to that observed in overt porphyria cutanea tarda and may be attributed to a decrease in activity of hepatic uroporphyrinogen (UROGEN) decarboxylase. The 3.5 diethoxycarbonyl-1,4-dihydrocollidine (DDC)-treated rat has been evaluated as a model to test the porphyrinogenicity of drugs.
D000818:Animals; D003306:Coproporphyrins / Q000032:analysis; D003997:Dicarbethoxydihydrocollidine / Q000009:adverse effects; D004353:Drug Evaluation, Preclinical; D005260:Female; D006581:Hexachlorobenzene / Q000009:adverse effects; D008099:Liver / Q000032:analysis; D008297:Male; D011164:Porphyrias / Q000139:chemically induced*; D051381:Rats; D014578:Uroporphyrins / Q000032:analysis
D003306:Coproporphyrins; D014578:Uroporphyrins; D006581:Hexachlorobenzene; D003997:Dicarbethoxydihydrocollidine