Human red blood cell membrane adenylate cyclase in sickle-cell disease.
The basal and the NaF-stimulated activities of human red blood cell membrane adenylate cyclase were found to be 5.3 +/- 0.8 (SE) and 219 +/- 76 (SE) pmol . mg-1 . min-1, respectively. Both activities were increased in nine patients with homozygous sickle-cell disease. There was no apparent correlation between this increase and the increase in the reticulocyte count.
D000262:Adenylyl Cyclases / Q000097:blood*; D000755:Anemia, Sickle Cell / Q000097:blood / Q000201:enzymology*; D001772:Blood Cell Count; D004910:Erythrocyte Membrane / Q000201:enzymology*; D004912:Erythrocytes / Q000201:enzymology*; D006720:Homozygote; D006801:Humans; D012156:Reticulocytes; D012969:Sodium Fluoride / Q000494:pharmacology
D012969:Sodium Fluoride; D000262:Adenylyl Cyclases