Defective yeast opsonization and C2 deficiency in atopic patients.
Twenty-seven per cent of atopic patients initially presenting with infantile eczema or hay fever were defective for yeast opsonization and 18% had low levels of C2; these deficiencies were mutually exclusive, suggesting that they are primary. Both defects were associated with each of four different atopic syndromes, some of which were related to certain HLA haplotypes.
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003175:Complement C2 / Q000172:deficiency*; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology*; D007223:Infant; D009504:Neutrophils / Q000276:immunology; D009895:Opsonin Proteins / Q000276:immunology*; D015003:Yeasts / Q000276:immunology*
D003175:Complement C2; D006680:HLA Antigens; D009895:Opsonin Proteins