Sodium-dependence of sustained force in potassium contracture of cat ventricle.
Following exposure to low-Na solutuion, the initial phase of K-contracture in cat ventricle is prominent while the second (sustained) phase is markedly attenuated. Monensin, a Na-specific ionophore, enhances the second phase of K-contracture following exposure to low-Na solution.
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002415:Cats; D066298:In Vitro Techniques; D008985:Monensin / Q000494:pharmacology; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000378:metabolism; D011188:Potassium / Q000494:pharmacology*; D012964:Sodium / Q000378:metabolism / Q000502:physiology*
D008985:Monensin; D012964:Sodium; D011188:Potassium; D002118:Calcium