Absence of IgG lymphocytotoxins in untreated Hodgkin's disease (HD) patients.
Six of twenty-three sera (26%) from patients with Hodgkin's disease (HD) contained IgG antibody with an affinity for human lymphocytes and lymphoblastoid cell lines. All sera were negative for complement-dependent and antibody-mediated cell cytotoxicity against human lymphoid cells irrespective of their binding capacity. It is suggested that the antilymphocyte antibodies seen in HD are not of pathogenic significance but are a non-specific consequence of B-cell stimulation.
D000915:Antibody Affinity; D000920:Antibody-Dependent Cell Cytotoxicity; D000961:Antilymphocyte Serum; D002460:Cell Line; D003165:Complement System Proteins / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D006689:Hodgkin Disease / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D008214:Lymphocytes / Q000276:immunology*
D000961:Antilymphocyte Serum; D007074:Immunoglobulin G; D003165:Complement System Proteins