title: Microheterogeneities, non-equivalance, and embryonic induction.
abstract: The thrust of this report is to stress the importance of microheterogeneities in the microenvironment of differentiating tissues as a possible inducer or regulator of differentiation. During chondrogenesis both qualitative and quantitative changes occur in the proteoglycan population. Using molecular sieve chromatography, these changes can be characterized and used as indices of differentiation. Microheterogeneities of the extracellular matrix may be an example of "non-equivalence" as a regulatory device for differentiation.
mesh_terms: D000818:Animals; D002356:Cartilage / Q000196:embryology; D002454:Cell Differentiation; D002850:Chromatography, Gel; D004627:Embryonic Induction; D006801:Humans; D008970:Molecular Weight; D011485:Protein Binding; D011509:Proteoglycans / Q000096:biosynthesis / Q000378:metabolism
chemical_list: D011509:Proteoglycans