[Dose for minimal sympathetic response to a painful stimulation for alphaxolone and thiopentone in man (author's transl)].
The dose that prevents the sympathetic response to a painful stimulation has been determined for alphaxolone and thiopentone (DRSM). The stimulation was the tracheal intubation and the sympathetic response has been evaluated as the percentual change of heart rate from the basal level. The DRSM has been determined as the dose that assures no percentual change of H.R. after intubation. The alphaxolone showed a DRSM very low (0.489) on the contrary the dose of thiopentone required to obtain no sympathetic response is high (7.776).
D000328:Adult; D000777:Anesthetics / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate; D006801:Humans; D007275:Injections, Intravenous; D007442:Intubation, Intratracheal; D008875:Middle Aged; D011277:Pregnanediones / Q000494:pharmacology*; D013564:Sympathetic Nervous System / Q000187:drug effects*; D013874:Thiopental / Q000494:pharmacology
D000777:Anesthetics; D011277:Pregnanediones; D013874:Thiopental
Dose pour la réponse sympathique minima aux stimuli douloureux, étude comparative entre l'alphaxolone et le thiopental.