Familial atypical multiple mole-melanoma syndrome.
A family is described showing concordance for malignant melanoma and a cutaneous phenotype characterised by multiple large moles of variable size and colour (reddish-brown to bright red) with pigmentary leakage. Transmission of the cutaneous phenotype in the subject family, and in several others currently under investigation, shows an inheritance pattern consistent with a simple autosomal dominant factor. This cutaneous phenotype signifying melanoma risk may now be added to an increasing body of knowledge dealing with cancer-related genodermatoses.
D000328:Adult; D005260:Female; D005799:Genes, Dominant; D006801:Humans; D008297:Male; D008545:Melanoma / Q000235:genetics*; D009506:Nevus / Q000235:genetics*; D010375:Pedigree; D010641:Phenotype; D012878:Skin Neoplasms / Q000235:genetics*; D013577:Syndrome