title: Synthesis of some 2,3-disubstituted quinazolones as possible anticonvulsants.
abstract: By the condensation of 2-phenyl-3-acylchloride quinazolin (3H)-4-one with N-phenyl- and N-methyl piperazines or piperidine, 15 new 2-phenyl-3-piperidino/substituted piperazino acyl-quinazolin (3H)-4-ones 1--3 have been prepared. All the compounds barring one exhibited at the 100 mg/kg dose level significant activity against pentylenetetrazol induced seizures but these compounds did not afford any protection against electroshock induced seizures.
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis*; D001522:Behavior, Animal / Q000187:drug effects; D004597:Electroshock; D007928:Lethal Dose 50; D051379:Mice; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D011799:Quinazolines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
chemical_list: D000927:Anticonvulsants; D011799:Quinazolines; D010433:Pentylenetetrazole