title: [The origin of complex coagulopathies in sleeping pill poisonings].
abstract: About 80 per cent of haemostasis disorders were found by systematic examinations of the clotting potential in 130 unselected moderately severe up to severe intoxications by tablets (degree of severity II--IV according to Reed). These disorders are essentially corresponding to a disseminated intravascular coagulation, but provided an extreme case they also may lead to a combination with production-, defect-, and casualty-coagulopathy. Occurring disorders in coagulation are to be treated dependent on stages by heparinisation, in case of need directed haemosubstitution and provided that a hyperfibrinolysis is proved also by antifibrinolytics. In special cases a--not too late beginning--therapy with streptokinase should be taken into consideration. These measures are to be classified into an optimal therapy regimen of detoxication and the exertion of influence of vital functions.
mesh_terms: D000328:Adult; D000933:Antifibrinolytic Agents / Q000627:therapeutic use; D001778:Blood Coagulation Disorders / Q000209:etiology* / Q000628:therapy; D001803:Blood Transfusion; D004211:Disseminated Intravascular Coagulation / Q000209:etiology; D005174:Factor XII; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D006993:Hypnotics and Sedatives / Q000506:poisoning*; D010974:Platelet Aggregation
chemical_list: D000933:Antifibrinolytic Agents; D006993:Hypnotics and Sedatives; D005174:Factor XII; D006493:Heparin
vernacular_title: Zur Komplexgenese der Koagulopathie bei Schlafmittelintoxikationen.