Preliminary screening of anticholinergic effect of some new derivatives of glycolic and aminoacetic acids.
The anticholinergic effect of some new alkylaminoalkyl esters of benzilic, cyclohexyl, 1-hydroxycyclohexyl, piperidino-and morpholino acetic acids (Table 1) was evaluated. Only benzilic acid esters were active and the 2-N-piperidinoaminoethyl benzilate hydrochloride (ANC-30) has the highest pA2 value.
D000818:Animals; D004353:Drug Evaluation, Preclinical; D005998:Glycine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity; D006016:Glycolates / Q000494:pharmacology* / Q000633:toxicity; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010276:Parasympatholytics; D051381:Rats
D006016:Glycolates; D010276:Parasympatholytics; D005998:Glycine