Teratogenic and dominant lethal studies of patulin in mice.
Teratogenicity of daily intraperitoneal (i.p.) injections of 1.5 or 2.0 mg/kg of patulin on days 6 through 17 of pregnancy and mutagenic effects of acute i.p. exposure of 3.0 mg/kg of patulin on male germ cells were evaluated. Resorption of all implanted embryos occurred at 2.0 mg/kg/day of patulin, while a significant reduction in the average body weight of 19-day-old fetuses from patulin-treated mothers, compared to control fetuses, was noticed at 1.5 mg/kg/day without any lethal effects on the implanted embryos. Patulin was embryocidal, possibly fetotoxic but was neither teratogenic nor mutagenic to mice.
D000818:Animals; D001724:Birth Weight / Q000187:drug effects; D005260:Female; D005799:Genes, Dominant / Q000187:drug effects*; D005804:Genes, Lethal / Q000187:drug effects*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010365:Patulin / Q000494:pharmacology*; D011247:Pregnancy; D011714:Pyrans / Q000494:pharmacology*; D012098:Reproduction / Q000187:drug effects; D013723:Teratogens
D011714:Pyrans; D013723:Teratogens; D010365:Patulin