title: [Changes caused by ultrasound in the isolated rat heart and in the rat heart in situ].
abstract: 1. The morphological alterations of rat hearts were investigated on isolated and on in situ organs after exposure to ultrasound. The ultrasonic waves, at 850 kHz frequency, were administered for 2 to 4 minutes with an energy of 2 to 4 watts/cm2. 2. In the exposed area, the pathological modifications are occurring in four successive steps. At the initial stage, the myocardial cells swell, at the second one one they contract and still later they show cleared spots and breakage lines, which may lead to fragmentation of the fibres. At the fourth stage the cells undergo a granular, mottling and vacuolar degeneration. 3. The epicardium demonstrates spotted blebs and swollen areas. It sometimes disintegrates or disappears, and can also cover some bleedings. Similar changes are found in the endocardium. 4. The alterations of the connective and endothelial cells correspond to those of the myocardial cells. Where the latter are swollen or contracted, the blood vessels are enlarged. In the regions with fragmented or degenerated muscle cells they are frequently necrotic. 5. In the wall of the left ventricle, the ventral part demonstrate more alterations than the dorsal one. However an exception is made by the tissues immediately next to border zones. Cellular and tissular damages augmented by increase in exposure period or energy.
mesh_terms: D000818:Animals; D004699:Endocardium / Q000473:pathology*; D008722:Methods; D009206:Myocardium / Q000473:pathology; D010496:Pericardium / Q000473:pathology*; D051381:Rats; D014465:Ultrasonics / Q000009:adverse effects*
vernacular_title: Durch Ultraschall bewirkte Veränderungen am isolierten Rattenherzen und am Rattenherzen in situ.