Inhibition of the development of the mammary glands of mice with a bromotriphenylethylene.
Administration of a bromotriphenylethylene to C3H/f(XVII/G) female mice implanted with a pituitary under the kidney capsule produces with high doses (200 mg/kg or 20 mg/kg of diet) a strong inhibition of the development of the mammary glands. With a low dose (2 mg/kg) no inhibition was observed. In mice which received the high doses no hyperplastic alveolar nodules were observed. The activity of the compound is more pronounced after 50 days than after 25 days.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D008321:Mammary Glands, Animal / Q000187:drug effects* / Q000254:growth & development; D051379:Mice; D008809:Mice, Inbred C3H; D010902:Pituitary Gland / Q000502:physiology / Q000637:transplantation; D013267:Stilbenes / Q000494:pharmacology*; D014185:Transplantation, Isogeneic
D013267:Stilbenes; C002425:phenylstilbene bromide