title: [Test of 0,0-dimethyl(1-hydroxy-2,2,2-trichlorethyl)phosphonate (Trichlorfon) for carcinogenic activity in Syrian golden hamsters (Mesocricetus auratus Waterhouse) by intraperitoneal administration (author's transl)].
abstract: 0,0-Dimethyl(1-hydroxy-2,2,2-trichlorethyl)phosphonate (Trichlorfon; TCP) was tested for carcinogenic activity in male and female Syrian hamsters (Mesocricetus auratus Waterhouse) by intraperitoneal administration. The period of administration was 90 weeks, when maximum total doses of 204 mg (male) and 206 mg (female) TCP per animal had been injected. The study was terminated at 100 weeks. There was no statistically significant difference, when compared the total tumour incidence, or the incidence of malignant and benign tumours separated, of the groups of treated and control animals. These findings were independent from whether the groups of TCP-injected animals and controls were combined or divided by sex.
mesh_terms: D000818:Animals; D006224:Cricetinae; D005260:Female; D007274:Injections, Intraperitoneal; D008297:Male; D009369:Neoplasms / Q000139:chemically induced*; D014236:Trichlorfon / Q000008:administration & dosage / Q000633:toxicity*
chemical_list: D014236:Trichlorfon
vernacular_title: Zur Prüfung von 0,0-Dimethyl(1-hydroxy-2,2,2-trichloräthyl)phosphonat (Trichlorphon) auf kanzerogene Wirkung in syrischen Goldhamstern (Mesocricetus auratus Waterhouse) durch intraperitoneale Injektion.