The effects of horseradish peroxidase on the concentration of 5-hydroxytryptamine and platelet counts in blood of rabbits and guinea pigs.
When HRP was injected i.v. in rabbits and guinea pigs, a rapid fall in the number of circulating platelets and the concentration of 5 HT occurred. Platelet aggregates were trapped in lung capillaries. The aggregation was reversible and the return of platelets to the circulation concomitant with a rise in blood 5 HT concentration.
D000818:Animals; D001772:Blood Cell Count; D001792:Blood Platelets; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D006735:Horseradish Peroxidase / Q000494:pharmacology; D008168:Lung / Q000648:ultrastructure; D010974:Platelet Aggregation / Q000187:drug effects; D011817:Rabbits; D012701:Serotonin / Q000097:blood*
D012701:Serotonin; D006735:Horseradish Peroxidase