Preliminary screening of anticholinergic effect of new 1,3-dioxolane and 1,3,-dioxane derivatives.
Some of the 28 investigated new derivatives show distinct anticholinergic activity. The greatest activity, that of 2-cyclohexyl-2-phenyl-5-piperidinodioxane-1,3 was greater than of the atropine sulfate.
D000818:Animals; D004146:Dioxanes / Q000494:pharmacology* / Q000633:toxicity; D004147:Dioxins / Q000494:pharmacology*; D004148:Dioxolanes / Q000494:pharmacology* / Q000633:toxicity; D004149:Dioxoles / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010276:Parasympatholytics; D051381:Rats
D004146:Dioxanes; D004147:Dioxins; D004148:Dioxolanes; D004149:Dioxoles; D010276:Parasympatholytics