title: A portable infusion pump, programmable with 16 rates.
abstract: An external, portable, programmable infusion pump has been developed for long-term therapeutic intravenous infusion of drugs. The impulse-controlled system consists of a 250 g CMOS-electronic unit, and an electromechanical infuser (250 g) containing a 10-ml disposable syringe. The infusion rate pattern is manually preprogrammed from 24 to 384 microliter/0.5 h. The coefficient of variation of the volume infused is less than 2% per. 0.5 h. The system has been tested by continuous administration of insulin in diabetics during 4 consecutive days, and can operate for 6-7 days with a 1 Ah, 5.4 V battery. The mean capillary blood glucose concentration could be maintained at levels close to normal (i.e. 7.0 mmol/1 +/- 2.3 (SD)) during the treatment period.
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D003201:Computers; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism*; D004582:Electronics, Medical / Q000295:instrumentation; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral / Q000295:instrumentation*; D007328:Insulin / Q000008:administration & dosage* / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D011312:Pressure; D013594:Syringes; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D007328:Insulin