Acute muscle necrosis after chronic overdosage of phenformin and fenfluramine.
A case of acute muscle necrosis with probable myoglobinuria is presented. The patient had been taking excessive doses of phenformin and fenfluramine, and a toxic etiology is suggested. Muscle necrosis is tentatively attributed either to the combined effect of these drugs on some underlying biochemical abnormality of muscle or to a defect of oxygen utilization secondary to myoglobin alterations.
D000208:Acute Disease; D000328:Adult; D004347:Drug Interactions; D005260:Female; D005277:Fenfluramine / Q000008:administration & dosage / Q000506:poisoning*; D006801:Humans; D009132:Muscles / Q000473:pathology*; D009135:Muscular Diseases / Q000139:chemically induced* / Q000473:pathology; D009336:Necrosis; D009765:Obesity / Q000188:drug therapy; D010629:Phenformin / Q000008:administration & dosage / Q000506:poisoning*; D019966:Substance-Related Disorders
D005277:Fenfluramine; D010629:Phenformin