Effects of prednisolone in 6 cases of glucocorticoid receptor-positive CLL.
The effect of treatment with prednisolone on clinical and laboratory variables was studied in 6 patients with chronic lymphocytic leukaemia (CLL). The laboratory variables analyzed on the leukaemic cells were surface immunoglobulin (S-Ig), sheep red blood cell receptors (SRBC), proliferative activity (PI) and glucocorticoid receptor (GR). In all cases the CLL was of B-cell type and the leukaemic cells contained a significant amount of GR. 4 out of 6 patients had a progressive disease with increased PI. On treatment they went into clinical remission, which was paralleled by a reduction in the leukaemic B-cell number and in PI. The amount of GR was unaffected. In 2 patients with nonprogressive disease, prednisolone produced no clearcut effect on clinical or laboratory variables.
D003165:Complement System Proteins; D006801:Humans; D007141:Immunoglobulin Fc Fragments; D007945:Leukemia, Lymphoid / Q000097:blood / Q000188:drug therapy* / Q000276:immunology; D011239:Prednisolone / Q000627:therapeutic use*; D011947:Receptors, Antigen, B-Cell / Q000032:analysis; D011965:Receptors, Glucocorticoid; D011987:Receptors, Steroid
D007141:Immunoglobulin Fc Fragments; D011947:Receptors, Antigen, B-Cell; D011965:Receptors, Glucocorticoid; D011987:Receptors, Steroid; D003165:Complement System Proteins; D011239:Prednisolone