title: Bromocriptine inhibits norepinephrine release.
abstract: Bromocriptine is a dopamine agonist that induces postural hypotension and can be used as an antihypertensive. The drug inhibits release of norepinephrine (NE) from an isolated artery by stimulating presynaptic receptors. In normotensive subjects it lowers both plasma and cerebrospinal fluid (CSF) levels of NE by 50% and lowers blood pressure moderately in standing subjects and slightly in recumbent subjects. Through central and peripheral mechanisms, bromocriptine inhibits sympathetic nervous discharge of NE.
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D001158:Arteries / Q000187:drug effects / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D001971:Bromocriptine / Q000494:pharmacology*; D004558:Electric Stimulation; D006801:Humans; D066298:In Vitro Techniques; D008875:Middle Aged; D009638:Norepinephrine / Q000378:metabolism* / Q000494:pharmacology; D011187:Posture; D011817:Rabbits; D013564:Sympathetic Nervous System / Q000187:drug effects* / Q000378:metabolism; D014661:Vasoconstriction / Q000187:drug effects
chemical_list: D001971:Bromocriptine; D009638:Norepinephrine