[Alkylation of delta 6-octalone-1].
In connection with the synthesis of shwarone (II), a sesquiterpinoid with interesting pharmacological properties, some results on the alkylation in the 9-position of the model substance delta6-octalone-1 (VI) are reported. Methylation, especially if carried out in polar aprotic solvents, gives mainly the trans derivative, this being the type needed for synthesis of compound (II); alkylation with allylbromides and propargyl gives mainly the cis isomer.
D000478:Alkylation; D000997:Antivenins / Q000138:chemical synthesis*; D002626:Chemistry, Pharmaceutical; D002849:Chromatography, Gas; D007313:Insecta; D007536:Isomerism; D008745:Methylation; D012717:Sesquiterpenes / Q000138:chemical synthesis*; D012910:Snake Venoms / Q000037:antagonists & inhibitors; D013055:Spectrophotometry, Infrared
D000997:Antivenins; D012717:Sesquiterpenes; D012910:Snake Venoms
Sull'alchilazione del delta6-ottalone-1.