title: The influence of dietary sulphur, molybdate and copper on the absorption, excretion and plasma fraction levels of 99Mo in sheep.
abstract: The effect of increased dietary sulphur, copper and molybdate on the metabolism of 99Mo administered via the rumen or duodenum was examined. Duodenally administered 99MoO4= was efficiently and rapidly absorbed and excreted via the urine; dietary modifications did not alter this pattern although increased dietary S increased the excretion rate. The passge of 99MoO4= through the rumen led to chemical modification, so that, particularly at high S levels, most of the radioactivity remained in the feces; increased dietary Mo led to increased absorption whereas increased copper decreased absorption. Incorportion of radioactivity into the TCA insoluble plasma fraction was shown with increased dietary S and particularly when both dietary S and Mo were increased. The compatiblity of the results with the hypothesis of ruminal thiomolybdate formation and subsequent reaction with dietary or tissue copper is discussed.
mesh_terms: D000818:Animals; D003300:Copper / Q000494:pharmacology*; D004032:Diet; D004386:Duodenum / Q000378:metabolism; D007408:Intestinal Absorption; D008297:Male; D008982:Molybdenum / Q000378:metabolism* / Q000494:pharmacology; D011868:Radioisotopes; D012417:Rumen / Q000378:metabolism; D012756:Sheep / Q000378:metabolism*; D013455:Sulfur / Q000494:pharmacology*
chemical_list: D011868:Radioisotopes; D013455:Sulfur; D003300:Copper; D008982:Molybdenum