Pancreatic amylase- and protein-concentrations associated with thioacetamide-induced cirrhosis of the liver in rats.
In cirrhosis of the liver induced in rats by administration of thioacetamide for 8 months, pancreatic amylase and protein concentration and the number of zymogen granules were found to exceed those of the controls. The finding is attributed to a deficient metabolism of enterohormones. The model seems to provide a suitable approach to the study of the hypersecretory state of the pancreas associated with cirrhosis of the liver.
D000081:Acetamides; D000681:Amylases / Q000032:analysis*; D000818:Animals; D004792:Enzyme Precursors / Q000032:analysis; D005260:Female; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000201:enzymology* / Q000473:pathology; D010179:Pancreas / Q000032:analysis / Q000201:enzymology* / Q000648:ultrastructure; D011506:Proteins / Q000032:analysis*; D051381:Rats; D013853:Thioacetamide
D000081:Acetamides; D004792:Enzyme Precursors; D011506:Proteins; D013853:Thioacetamide; D000681:Amylases