title: Homotaurine and muscimol mimic taurine and GABA effects on muscle tone and temperature regulation.
abstract: Taurine, homotaurine, GABA and muscimol, given intraventricularly to the conscious, unrestrained  rabbit cause hypothermia and a reduction in skeletal muscle tone. Taurine and homotaurine desynchronize areas of the motor and limbic cortices, with GABA and muscimol synchronize both tracings and markedly depress the arousal reaction following external stimuli.
mesh_terms: D000596:Amino Acids / Q000494:pharmacology; D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D004569:Electroencephalography; D005260:Female; D066298:In Vitro Techniques; D007276:Injections, Intraventricular; D008297:Male; D009118:Muscimol / Q000494:pharmacology*; D009129:Muscle Tonus / Q000187:drug effects*; D010080:Oxazoles / Q000494:pharmacology*; D011817:Rabbits; D013654:Taurine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
chemical_list: D000596:Amino Acids; D010080:Oxazoles; D013654:Taurine; D009118:Muscimol; D005680:gamma-Aminobutyric Acid; C001355:tramiprosate