[Blood lactate and biguanide therapy: comparison between phenformin, metformin and buformin in 408 senile diabetics].
In our series of patients, blood lactate is investigated in type II-diabetics under sulfonylurea or sulfonylureabiguanid treatment. Under biguanides a statistically significant increase of blood lactate is found dose-dependent, but independent of the type of biguanides used.
D000368:Aged; D001645:Biguanides / Q000009:adverse effects* / Q000627:therapeutic use; D002026:Buformin / Q000009:adverse effects / Q000627:therapeutic use; D003920:Diabetes Mellitus / Q000097:blood / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007773:Lactates / Q000097:blood*; D008297:Male; D008687:Metformin / Q000009:adverse effects / Q000627:therapeutic use; D010629:Phenformin / Q000009:adverse effects / Q000627:therapeutic use
D001645:Biguanides; D007773:Lactates; D008687:Metformin; D010629:Phenformin; D002026:Buformin
Blutlaktat und Biguanidtherapie: Vergleich zwischen Phenformin, Metformin und Buformin bei 408 Altersdiabetikern.