Nitrogen mustards derived from alpha-hydroxymethyleneketones.
alpha-[Bis-(2-chloroethyl)]aminomethyleneketones were prepared starting from alpha-hydroxymethyleneketones and N-(2-chloroethyl)-2-chloroethanamine. Also 3-[2-(2-chloroethylthio)ethyl]aminomethylene-2-bornanone was synthesized from 2-(2-chloroethylthio)ethanamine and 3-hydroxymethylene-2-bornanone. This compound and 3-[bis-(2-chloroethyl]aminoemthylene-2-norbornanone were active against P388 lymphocytic leukemia in mice.
D000818:Animals; D005260:Female; D007659:Ketones; D007942:Leukemia, Experimental / Q000188:drug therapy; D008722:Methods; D051379:Mice; D009588:Nitrogen Mustard Compounds / Q000138:chemical synthesis* / Q000627:therapeutic use
D007659:Ketones; D009588:Nitrogen Mustard Compounds