title: [Caffeine-11C, ephedrine-11C and methylephedrine-11C: Synthesis and distribution in mice (author's transl)].
abstract: Caffeine, ephedrine and methylephedrine were labeled with carbon-11 by the action of methyliodide-11C on theophylline, norephedrine and ephedrine, respectively. Caffeine-11C was prepared in 44 min with a radiochemical yield of 40%, ephedrine-11C in 45 min with a 11% radiochemical yield and methylephedrine-11C in 36 min with a 43% radiochemical yield. When injected in mice intravenously, these products show a high uptake in the liver, the kidney and the blood for caffeine-11C and in the liver and the kidney for ephedrine-11C and methylephedrine-11C. The brain uptake for these products was found to be 2.4 to 3.9% of the injected dose per gram at 5 min after injection. These studies in mice have demonstrated that these products are potentially useful agents for the dynamic studies of the brain.
mesh_terms: D000818:Animals; D002110:Caffeine / Q000138:chemical synthesis* / Q000378:metabolism; D002250:Carbon Radioisotopes; D004809:Ephedrine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism; D007553:Isotope Labeling; D008297:Male; D008745:Methylation; D051379:Mice; D010665:Phenylpropanolamine; D013806:Theophylline; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D002250:Carbon Radioisotopes; D010665:Phenylpropanolamine; D002110:Caffeine; D013806:Theophylline; D004809:Ephedrine