Chemoneurolysis of the canine gastric submucosa. Effects on surgically-induced gastric hypersecretion on the Heidenhain pouch.
Double denervated gastric pouches were constructed in dogs. One gastric pouch served as a control, and the other gastric pouch had its submucosa infiltrated with 25% ethyl alcohol, (submucosal chemoneurolysis). Neurolysis of these gastric pouches eliminated their gastric secretory responses to histamine, meat and pentagastrin without altering their histological appearance. Transplantation of 75% of the gastric antrum into the colon caused a hypergastrinemia and increased the sensitivity of the control gastric pouches to the various stimuli but had no such effect on those gastric pouches infiltrated with ethyl alcohol.
D000818:Animals; D003106:Colon / Q000601:surgery; D003714:Denervation; D004285:Dogs; D000431:Ethanol / Q000494:pharmacology; D005260:Female; D005502:Food; D005753:Gastric Mucosa / Q000187:drug effects / Q000294:innervation / Q000378:metabolism*; D005755:Gastrins / Q000097:blood*; D006632:Histamine / Q000494:pharmacology; D008297:Male; D010418:Pentagastrin / Q000494:pharmacology; D013270:Stomach / Q000294:innervation / Q000502:physiology* / Q000637:transplantation
D005755:Gastrins; D000431:Ethanol; D006632:Histamine; D010418:Pentagastrin