Production of complete and incomplete antibodies to human red blood cells in dogs and rabbits.
The characteristics of the immune response of dogs and rabbits to single and multiple injections of human red blood cells were analysed. The results show that the primary and secondary response of both species are essentially the same. Following repeated stimulation with this antigen quantitative differences of the immune response between these animals were observed. The rabbit produced substantially greater amounts of IgG complete and incomplete antibody, and proportionally greater amounts of IgM antibody, whereas the dog response was seen to be inhibited.
D000818:Animals; D000917:Antibody Formation; D000936:Antigen-Antibody Complex; D004285:Dogs; D004912:Erythrocytes / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis*; D007075:Immunoglobulin M / Q000096:biosynthesis*; D007156:Immunologic Memory; D011817:Rabbits
D000936:Antigen-Antibody Complex; D007074:Immunoglobulin G; D007075:Immunoglobulin M