The induction of cystitis and the implantation of tumours in rat and rabbit bladders.
A method of inducing tumour growth in rat and rabbit bladders is described. Tumour induction is dependent on a pre-induced cystitis. In rats, tumour also grows in the kidneys because of species characteristic vesicoureteric reflux. The possible significance is discussed in relation to the management of human bladder tumours.
D000818:Animals; D000892:Anti-Infective Agents, Urinary / Q000009:adverse effects; D002593:Cetrimonium Compounds / Q000009:adverse effects; D003556:Cystitis / Q000139:chemically induced / Q000150:complications; D005260:Female; D007680:Kidney Neoplasms / Q000209:etiology; D009368:Neoplasm Transplantation; D011817:Rabbits; D051381:Rats; D012513:Sarcoma, Experimental / Q000209:etiology; D001749:Urinary Bladder Neoplasms / Q000209:etiology*; D014718:Vesico-Ureteral Reflux / Q000150:complications
D000892:Anti-Infective Agents, Urinary; D002593:Cetrimonium Compounds