title: [Reproduction of amyloidosis in mice by contact sensitization with dinitrochlorobenzene].
abstract: Induction of murine amyloidosis by contact sensitization with hapten--dinitrochlorobenzene is described. Three to five applications of 15--25% dinitrochlorobenzene solution in acetone during two weeks are necessary for this. Within 3 weeks after the 1st application amyloidosis develops involving consecutively the spleen, liver, kidney and heart. Such consequence of the organ involvement and tinctorial pecularities are typical of murine amyloidosis.
mesh_terms: D000686:Amyloidosis / Q000139:chemically induced* / Q000276:immunology; D000818:Animals; D004137:Dinitrochlorobenzene / Q000008:administration & dosage / Q000276:immunology*; D004195:Disease Models, Animal; D007114:Immunization; D051379:Mice; D009578:Nitrobenzenes / Q000276:immunology*; D013997:Time Factors
chemical_list: D004137:Dinitrochlorobenzene; D009578:Nitrobenzenes
vernacular_title: Vosproizvedenie amiloidoza u mysheĭ kontaktnoĭ sensibilizatsieĭ dinitrokhlorbenzolom.