Steroid levels in the serum and seminal plasma during clomiphene therapy in hypofertile men.
The serum and seminal plasma concentrations of androstenedione, testosterone, dihydrotestosterone and 17beta-oestradiol were investigated in hypo- and oligospermic males during clomiphene-citrate, administration. A significant increase was demonstrated in the serum testosterone, dihydrosterone and 17beta-oestradiol values, mainly in the first month of therapy. The steroid increase in the ejaculate was less pronounced. Measuring of 17beta-oestradiol in serum appears to be a useful parameter for estimating the stimulative effect of clomiphene citrate.
D000728:Androgens / Q000097:blood / Q000378:metabolism*; D000735:Androstenedione / Q000097:blood / Q000378:metabolism; D002996:Clomiphene / Q000627:therapeutic use*; D013196:Dihydrotestosterone / Q000097:blood / Q000378:metabolism; D004958:Estradiol / Q000097:blood / Q000378:metabolism*; D006801:Humans; D008297:Male; D009845:Oligospermia / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D012661:Semen / Q000378:metabolism*; D013739:Testosterone / Q000097:blood / Q000378:metabolism
D000728:Androgens; D013196:Dihydrotestosterone; D002996:Clomiphene; D013739:Testosterone; D000735:Androstenedione; D004958:Estradiol