Induction of lactation by two techniques: success rate, milk composition, estrogen and progesterone in serum and milk, and ovarian effects.
Induction of lactation was attempted in 12 heifers and 12 cows with estradiol benzoate (.011 mg/kg body weight per day) subcutaneous for 10 days or that plus progesterone (.1 mg + .25 mg/kg body weight per day) for 7 days. Milking commenced on day 20 for those treated with the mixture and on day 11 for the others. Lactations were induced (minimum of 4.5 kg of milk/day) in five of six heifers and two of six cows by the mixture and in six of six heifers and three of six cows for estradiol benzoate. Milk production was 44% of herdmates in the 16 induced lactations. Cows on the single treatment had lower production than the other three groups. Ovarian status, cycling, cystic, or static, was affected adversely in 5 of 16 animals induced successfully. Two of the 16, both heifers, carried calves to term following induction. The transition to normal composition of milk was slower for single than double treatment. Lactose increased slowly to normal over the 1st wk of milking while protein decreased slowly. Estrogen and progesterone in milk of induced cows were approximately twice as concentrated as in normal postparturient cows, probably because milk production was halved.
D000818:Animals; D002417:Cattle; D004958:Estradiol / Q000494:pharmacology*; D004967:Estrogens / Q000378:metabolism*; D005260:Female; D007700:Kinetics; D007774:Lactation / Q000187:drug effects*; D008892:Milk / Q000378:metabolism*; D010053:Ovary / Q000187:drug effects / Q000502:physiology*; D011247:Pregnancy; D011374:Progesterone / Q000378:metabolism* / Q000494:pharmacology*
D004967:Estrogens; D011374:Progesterone; D004958:Estradiol