title: [Metabolic transformations of the trimethyl - 3,5,5, cyclohexene-2, one-1 (isophorone) (author's transl)].
abstract: In the rabbit, isophorone alpha is partly eliminated, unchanged in the expired air and in the urine and, for another part, metabolized in the organism and excreted in the urine. The metabolites which have been characterized are : dimethyl-5,5, cyclohexen-1, one-3, carboxylic-1 acid, deriving from isophorone by methyloxidation, isophorol (trimethyl-3,5,5 cyclohexen-2, ol-1) formed by the reduction of the ketonic group into a secondary alcohol and eliminated as a glucuronide, dihydroisophorone (trimethyl-3,5,5, cyclohexanone) proceeding from the hydrogenation of the cyclohexen cycle and cis and trans trimethyl-3,5,5, cyclohexanols-1. These latter compounds, found in small quantities, are very likely issued from dihydroisophorone which is transformed in the organism into isophorone alpha and cis and trans trimethyl-3,5,5, cyclohexanols-1, according to a process of dismutation.
mesh_terms: D000818:Animals; D001711:Biotransformation; D003510:Cyclohexanes / Q000378:metabolism*; D003512:Cyclohexanones / Q000378:metabolism*; D005965:Glucuronates / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D012997:Solvents / Q000378:metabolism*
chemical_list: D003510:Cyclohexanes; D003512:Cyclohexanones; D005965:Glucuronates; D012997:Solvents; C005940:isophorone
vernacular_title: Transformations métaboliques de la triméthyl-3,5,5, cyclohexène-2, one-1 (isophorone).