Termination of second trimester pregnancy with intraamniotic administration of 16-phenoxy-omega-tetranor-PgE2-methylsulfonamide (SHB 286) alone and combined with oxytocin and calcium gluconate.
Midtrimester abortion was succesfully induced within 30 hours in 62 out of 90 patients by intraamniotic administration of 16-phenoxy-omega-17,18,19, 20-tetranor-prostaglandine-E2-methylsulfonamide. The Pg-analogue was tested in 5 groups of patients which received 1,2 or 3 mg. In group IV, 2 mg of the analogue was combined with oxytocin. In group V, 3 mg of the analogue was combined with 2.75 grams of calcium gluconate. The success rate was significantly influenced by the amount of the drug administered. Side effects were minimal. Multiparous women respond better to the therapy than nulliparous patients. The combination with oxytocin was more effective than the Pg-analogue alone and the combination of sulprostone with calcium gluconate was 87% succesful within 30 hours and 100% succesful within 36 hours.
D000028:Abortion, Induced; D000293:Adolescent; D000328:Adult; D000650:Amnion; D002125:Calcium Gluconate / Q000627:therapeutic use*; D055598:Chemical Phenomena; D002621:Chemistry; D015232:Dinoprostone / Q000031:analogs & derivatives; D004359:Drug Therapy, Combination; D005260:Female; D005942:Gluconates / Q000627:therapeutic use*; D006801:Humans; D007267:Injections; D010121:Oxytocin / Q000627:therapeutic use*; D010298:Parity; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011459:Prostaglandins E, Synthetic / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D013997:Time Factors; D014839:Vomiting / Q000139:chemically induced
D005942:Gluconates; D011459:Prostaglandins E, Synthetic; D010121:Oxytocin; C016767:sulprostone; D015232:Dinoprostone; D002125:Calcium Gluconate