Synthesis of derivatives of 2-amino-4-p-chlorophenylthiazole-5-acetic acid.
In the course of studies on compounds with expected antiinflammatory and immunosuppressive action a number of new derivatives of 2-amino-4-p-chlorophenylthiazole-s-acetic acid have been synthetized. The chemical structure of these compounds has been confirmed by elemental analysis and IR spectra. The newly obtained compounds were investigated pharmacologically. It has been found that some of the derivatives possess antiinflammatory and immunosuppressive activity.
D000596:Amino Acids / Q000138:chemical synthesis* / Q000633:toxicity; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis; D007166:Immunosuppressive Agents / Q000138:chemical synthesis; D008722:Methods; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis* / Q000633:toxicity
D000596:Amino Acids; D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D013844:Thiazoles