[Stimulation of nuclear membrane components and DNA biosynthesis in rat liver cells after inhibition of translation with cycloheximide].
After a drastic inhibition of protein synthesis (95%) in rat liver by cycloheximide (0.2-0.4 mg/100 g of body weight) the recovery and subsequently prolonged marked stimulation of proteins, lipids and DNA were found. The correlation of nuclear membrane proteins and lipids synthesis was observed in a recovery and stimulation phases. Nuclear DNA synthesis increases after the stimulation biosynthesis of nuclear membrane components (36-40 hours after cycloheximide injection). The changes of a phospholipid composition and structure organisation of nuclear membrane hydrophobic zones (by spin probe) were found in stimulated DNA synthesis (48-60 hours).
D000818:Animals; D003513:Cycloheximide / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis*; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D009685:Nuclear Envelope / Q000187:drug effects*; D010743:Phospholipids / Q000378:metabolism; D014176:Protein Biosynthesis / Q000187:drug effects; D051381:Rats; D013997:Time Factors
D010743:Phospholipids; D004247:DNA; D003513:Cycloheximide
Stimuliatsiia sinteza komponentov iadernoĭ membrany i DNK kletok pecheni krys posle ingibirovaniia transliatsii tsiklogeksimidom.