Standardization of anticoagulant control.
Oral anticoagulant treatment is widely administered, particularly for the management and prophylaxis of thrombo-embolism. Anticoagulant dosage requires laboratory monitoring. An international system of standardization of laboratory control is necessary. A system based on the provision of a standardized tissue extract of thromboplastin (British Comparative Thromboplastin) is described. This is used in laboratories in seventy countries including a representative group of Italian hospitals and is now recommended as the international reference preparation.
D000925:Anticoagulants / Q000008:administration & dosage*; D004739:England; D006801:Humans; D007391:International Cooperation; D007753:Laboratories / Q000592:standards; D011517:Prothrombin Time / Q000592:standards*; D011786:Quality Control; D012015:Reference Standards; D013925:Thromboplastin; D013927:Thrombosis / Q000517:prevention & control*; D014944:World Health Organization
D000925:Anticoagulants; D013925:Thromboplastin