The antifertility action of alpha-chlorohydrin: enzyme inhibition by alpha-chlorohydrin phosphate.
Preparations of the enzymes glyceraldehyde-3-phosphate dehydrogenase and triosephosphate isomerase are shown to be inhibited by alpha-chlorohydrin phosphate (II) in a competitive and non-competitive manner, respectively. alpha-Chlorohydrin (I), glycidol and epi-chlorohydrin have no inhibitory activities suggesting that their antifertility actions are due to their metabolism in vivo to alpha-chlorohydrin phosphate.
D000818:Animals; D002238:Carbohydrate Epimerases / Q000037:antagonists & inhibitors*; D002728:Chlorohydrins / Q000494:pharmacology*; D003272:Contraceptive Agents, Male / Q000494:pharmacology*; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000037:antagonists & inhibitors*; D007700:Kinetics; D008297:Male; D009132:Muscles / Q000201:enzymology; D010766:Phosphorylation; D011817:Rabbits; D013094:Spermatozoa / Q000201:enzymology; D014305:Triose-Phosphate Isomerase / Q000037:antagonists & inhibitors*; D000517:alpha-Chlorohydrin / Q000031:analogs & derivatives / Q000494:pharmacology*
D002728:Chlorohydrins; D003272:Contraceptive Agents, Male; D000517:alpha-Chlorohydrin; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases; D002238:Carbohydrate Epimerases; D014305:Triose-Phosphate Isomerase