title: [Biological characteristics of influenza B viruses isolated during influenza B epidemics in 1976-1977].
abstract: Comparative studies of the antigenic structure of influenza B viruses isolated in 1976-1977 and in previous years demonstrated one-way relationship of the hemagglutinin of B/76 viruses with that of B/72 viruses. Antisera to new B/76 strains neutralized the hemagglutinating activity of all known reference influenza B virus strains beginning from 1972. Influenza B/76 viruses were divided into two groups depending on complete or partial neutralization by antiserum B/Hong Kong/7/75. The study of the antigenic structure of neuraminidase showed no significant differences between influenza B/76 and B/72 virus neuraminidase. All the influenza B viruses from different years under study had marked interferon-inducing properties and were sensitive to interferon. Unlike the Yamagata/1/73 strain, all the influenza B/76 viruses under study were resistant to thermostable inhibitors of normal horse, guinea pig, and rabbit sera.
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D000956:Antigens, Viral / Q000032:analysis; D002417:Cattle; D004196:Disease Outbreaks; D006168:Guinea Pigs; D006388:Hemagglutinins / Q000032:analysis; D006736:Horses; D006801:Humans; D007106:Immune Sera / Q000276:immunology; D007251:Influenza, Human / Q000382:microbiology*; D051379:Mice; D009031:Moscow; D009439:Neuraminidase / Q000378:metabolism; D009500:Neutralization Tests; D009975:Orthomyxoviridae / Q000276:immunology / Q000472:pathogenicity / Q000502:physiology*; D011817:Rabbits; D051381:Rats; D013696:Temperature
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; D006388:Hemagglutinins; D007106:Immune Sera; D009439:Neuraminidase
vernacular_title: Biologicheskaia kharakteristika virusov grippa B, vydelennykh vo vremia epidemii grippa v 1976-1977.