Copper metabolism in different states of erythropoiesis activity.
The interrelationship between erythropoiesis activity and the dynamic of copper metabolism in normal rats and the rats with experimentally induced anemia and polycythemia was studied, using 64Cu injected intravenously in the form of CuCl2. The studies demonstrated that the copper metabolism is different in erythropoiesis stimulation and inhibition. Significant changes in the plasma ceruloplasmin level and the plasma copper content as well as in the plasma copper clearance and blood copper turnover were observed.
D000740:Anemia / Q000503:physiopathology; D000818:Animals; D001815:Bloodletting; D002570:Ceruloplasmin / Q000032:analysis; D003300:Copper / Q000032:analysis / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology; D004912:Erythrocytes / Q000032:analysis; D004920:Erythropoiesis / Q000187:drug effects; D005260:Female; D008297:Male; D011086:Polycythemia / Q000503:physiopathology; D051381:Rats; D014018:Tissue Distribution
D003300:Copper; D002570:Ceruloplasmin