[tert-Butylation of the tryptophan indole ring during the removal of the tert-butyloxycarbonyl group (author's transl)].
The tert-butylation of the tryptophan indole ring during the removal of tert-butyloxycarbonyl groups under different conditions was studied. The incorporation of tert-butyl groups was measured by a 1H-NMR technique. It was established, that the rate and specificity of the tert-butylation is highly dependent on the character of the cleaving reagents used and on the environment of the tryptophan residue in the peptide chain.
D055598:Chemical Phenomena; D002621:Chemistry; D002855:Chromatography, Thin Layer; D009682:Magnetic Resonance Spectroscopy; D008722:Methods; D010455:Peptides / Q000138:chemical synthesis*; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship; D014364:Tryptophan / Q000031:analogs & derivatives*
D010455:Peptides; D014364:Tryptophan
tert-Butylierung des Tryptophan-Indolringes während der Abspaltung der tert-Butyloxycarbonyl-Gruppe bei Peptidsynthesen.