title: The action of prostaglandin E2 and F1alpha on myocardial ischaemia-infarction arrhythmias in the dog.
abstract: Prostaglandin E2 and F1alpha infusions have been tested for their ability to reduce the arrhythmias associated with occlusion of the left descending coronary artery in the anaesthetised dog. At 1 microgram/kg/min both PGs reduced the incidence of premature ventricular contractions occurring during 25-min occlusions, while not reducing the incidence of ventricular fibrillation occurring on occlusion release. When infused for 5-min periods at 1 to 16 microgram/kg/min, neither PGE2 nor PGF1alpha effectively reduced the frequency of ventricular arrhythmias occurring 24 hr after a permanent coronary occlusion.
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000188:drug therapy* / Q000209:etiology; D003327:Coronary Disease / Q000150:complications*; D004285:Dogs; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D007263:Infusions, Parenteral; D008026:Ligation; D008297:Male; D009203:Myocardial Infarction / Q000150:complications; D011459:Prostaglandins E, Synthetic / Q000008:administration & dosage / Q000627:therapeutic use*; D011461:Prostaglandins F, Synthetic / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors; D014693:Ventricular Fibrillation / Q000188:drug therapy
chemical_list: D011459:Prostaglandins E, Synthetic; D011461:Prostaglandins F, Synthetic