Effect of tinofedrine (Homburg D8955) on cerebral blood flow in multi-infarct dementia.
Tinofedrine, a new derivative of l-norephedrine, was examined for cerebral vasodilator activity in man. Ten patients with reduced cerebral blood flow (CBF) and multi-infarct dementia were given the drug intravenously. Cerebral blood flow increased significantly by 28% from a mean of 43.3 to 55.5 ml/100 g/min.
D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000098:blood supply*; D002245:Carbon Dioxide / Q000097:blood; D002544:Cerebral Infarction / Q000150:complications / Q000188:drug therapy*; D003704:Dementia / Q000188:drug therapy* / Q000209:etiology; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D010665:Phenylpropanolamine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D012039:Regional Blood Flow / Q000187:drug effects; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use*
D014665:Vasodilator Agents; D002245:Carbon Dioxide; D010665:Phenylpropanolamine