Biomembrane characteristics in stroke-prone spontaneously hypertensive rats (SHRSP).
Biomembrane characteristics in stroke-prone SHR (SHRSP) and stroke-resistant SHR (SHRSR) were examined using erythrocytes as a simplified model. When erythrocytes were exposed to osmotic stress in the process of the migration from a higher to a lower osmotic gradient by the coil planet centrifugation, erythrocytes from SHRSP were hemolyzed at a higher osmotic pressure than those from SHRSR. Such a difference in biomembrane characteristics may be useful for detecting a genetic disposition of stroke.
D000818:Animals; D002463:Cell Membrane Permeability; D002561:Cerebrovascular Disorders / Q000097:blood* / Q000150:complications; D006973:Hypertension / Q000097:blood* / Q000150:complications; D009996:Osmotic Fragility; D051381:Rats