[Toxicity of the pesticide nabam as a function of dietary protein content in the rat].
With the object of studying a possible toxical potentialization between a food pollutent and the diet compoundings, rats fed on a diet with variable protein amounts, were administered a pesticide belonging to the Dithiocarbamate family : Nabam. Animals have been fed for 28 days after they have been weaned with diets containing 0-3.5 - 9 - 26 and 81% proteins in casein form. DL50 is significantly lowered in rats fed 0 - 3,5 and 81% protein diets compared with DL50 estimations in rats normally fed. Toxical clinical signs are fundamentally the same ones in all rats of the six groups : stimulation followed by a depression of the central nervous system, severe inflammation of the gastro-intestinal tractus, significant renal necroses. The intertime between poisoning and death seems not to be influenced by the diet protein amounts and is only due to the Nabam dose.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004044:Dietary Proteins / Q000494:pharmacology*; D005028:Ethylenebis(dithiocarbamates) / Q000633:toxicity*; D005659:Fungicides, Industrial / Q000633:toxicity*; D006540:Herbicides / Q000633:toxicity*; D007928:Lethal Dose 50; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D013859:Thiocarbamates / Q000633:toxicity*; D013997:Time Factors
D004044:Dietary Proteins; D005028:Ethylenebis(dithiocarbamates); D005659:Fungicides, Industrial; D006540:Herbicides; D013859:Thiocarbamates; C005270:nabam
Toxicité d'un pesticide, le nabame, en fonction du taux protéique alimentaire chez le rat.