[Significance of the hemodynamics for the extent of the rejection. Comparison of immunological reactions in artery transplantation in high pressure and vein transplantation in low pressure systems in matching inbred rat strain combinations].
Systemic sensitization is induced by arterial transplants in the high pressure system and by venous transplants in the low pressure system. In aorta transplantation the severity of the rejection corresponds directly to the immunogenetic differences between donor and recipient; the efferent limb is triggered into action. For application of allogeneic veno-venous transplants this is not the case: despite systemic sensitization, even strongly allogeneic venous transplants are maintained over long periods. A threshold value is not reached unless there is presensitization with strong antigens, after which morphologically comprehensible rejection reactions, i.e. round cell infiltration, are demonstrated even in veno-venous transplants.
D000818:Animals; D000906:Antibodies / Q000032:analysis; D001011:Aorta / Q000601:surgery; D001158:Arteries / Q000637:transplantation*; D001794:Blood Pressure; D006084:Graft Rejection; D051381:Rats; D011919:Rats, Inbred Strains / Q000276:immunology*; D014184:Transplantation, Homologous; D014680:Veins / Q000637:transplantation*; D014684:Venae Cavae / Q000601:surgery
D000906:Antibodies
Die Bedeutung der Hämodynamik für die Stärke der Abstossungsreaktion. Vergleich der immunologischen Reaktionen bei Arterientransplantion im Hoch- und Venentransplantation im Niederdrucksystem bei entsprechenden Ratteninzuchtstammkombinationen.