Serum theophylline levels in asthmatic children after oral administration of two slow-release theophylline preparations.
Serum theophylline levels were measured throughout the day in 65 asthmatic children receiving one of two slow-release theophylline compounds. There was a wide interindividual variation in levels obtained with similar doses of pure theophylline, and also a wide intraindividaual variation in levels throughout the day, suggesting that the rates of release and/or absorption of theophylline from these compounds are not uniform. There were fewer side effects associated with taking these compounds than with choline theophyllinate.
D000284:Administration, Oral; D000293:Adolescent; D000367:Age Factors; D001249:Asthma / Q000097:blood* / Q000188:drug therapy; D002648:Child; D002675:Child, Preschool; D003692:Delayed-Action Preparations; D006801:Humans; D013806:Theophylline / Q000008:administration & dosage / Q000097:blood* / Q000627:therapeutic use; D013997:Time Factors
D003692:Delayed-Action Preparations; D013806:Theophylline