[Lorcainid--electrophysiologic examinations of a new anti-arrhythmia agent].
The electrophysiologic properties of Lorcainide (1.25 and 2.5 mg/kg) were studied on 21 patients by intracardiac electrograms and atrial stimulation. A prolongation of the H-V interval, widening of QRS duration but only minor changes in A-H interval were found. The effective refractory period of the atria increased, the effective and functional refractory periods of the A-V node changed variable following Lorcainide. There was a slight increase in heart rate and the sinus node recovery time was longer after 2.5 mg/kg of the drug. The major site of action of Lorcainide in man appears to be the His-Purkinje system. In electrophysiologic terms the new antiarrhythmic agent closely resembles Aprindine.
D000083:Acetanilides / Q000627:therapeutic use; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001146:Arrhythmia, Sinus / Q000188:drug therapy; D001145:Arrhythmias, Cardiac / Q000188:drug therapy*; D002036:Bundle of His / Q000187:drug effects; D002037:Bundle-Branch Block / Q000188:drug therapy; D002304:Cardiac Pacing, Artificial; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D010880:Piperidines / Q000627:therapeutic use*; D012849:Sinoatrial Node / Q000187:drug effects
D000083:Acetanilides; D000889:Anti-Arrhythmia Agents; D010880:Piperidines
Lorcainid--Elektrophysiologische Untersuchungen eines neuen Antiarrhythmikums.