title: [Simultaneous hormonal and drug therapy, compared to hormonal therapy, followed by chemotherapy, in the treatment of metastasizing breast neoplasms. Preliminary results of an ongoing study].
abstract: The preliminary results of a still ongoing phase III study in patients with previously untreated metastatic breast cancer are reported. 210 cases are already evaluable. In this study patients are randomized to hormonotherapy either concurrently with combination chemotherapy or alone, chemotherapy being delayed until the occurrence of tumor progression. In both groups patients are further randomly allocated to 3 chemotherapy programs. So far there appear to be differences between remission rates, but not with regard to survival course.
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000628:therapy; D002369:Castration; D004359:Drug Therapy, Combination / Q000379:methods; D005260:Female; D006801:Humans; D008593:Menopause; D009362:Neoplasm Metastasis; D013629:Tamoxifen / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D013629:Tamoxifen
vernacular_title: Gleichzeitige Hormon- und Chemotherapie, verglichen mit Hormontherapie, gefolgt von Chemotherapie, bei der Behandlung des metastasierenden Mammakarzinoms. Präliminäre Resultate einer laufenden Studie.