title: Procarbazine (Natulan) in the treatment of Peyronie's disease.
abstract: Thirty-four men with Peyronie's diseases were treated with a 12-week course of the drug procarbazine (Natulan), preceded or followed by a 12-week course of vitamin E. Ninety-one per cent of the men failed to improve or became worse whilst receiving Natulan and toxic side-effects were common. In comparison 39% improved whilst taking vitamin E. We concluded that Natulan is of little benefit in the treatment of this condition and may indeed be harmful.
mesh_terms: D000328:Adult; D000368:Aged; D004341:Drug Evaluation; D006801:Humans; D008297:Male; D008875:Middle Aged; D010411:Penile Induration / Q000188:drug therapy*; D011344:Procarbazine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D014810:Vitamin E / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D014810:Vitamin E; D011344:Procarbazine