title: [Effect of protein additives in mouse food on immune response to sheep red blood cells in mice (author's transl)].
abstract: Protein additives used in mouse food (fish meal, bovine blood meal, milk powder) interfere with the specific immune response induced with sheep red blood cells. Bovine blood meal reduces delayed type hypersensitivity (DTH) reactions and delays IgG production. Blood derivatives suppress mostly the central induction and not the peripheral expression of DTH since depression can be shown after systemic and not after subcutaneous immunization. The suppression of DTH is specific, it did not appear when DTH was produced with antigens presenting no antigenic cross-reactivity with protein additives (chicken red blood cells, tuberculin). This depressive effect was related neither to the presence of inhibitory serum factor nor to the production after immunization of specific antigen-antibody-blocking factor. Blood derivatives seem to act on the afferent arc of immune response especially on the splenic immunogenicity of the injected antigen to produce DTH.
mesh_terms: D000818:Animals; D000937:Antigen-Antibody Reactions; D000941:Antigens; D003429:Cross Reactions; D004912:Erythrocytes / Q000276:immunology; D005433:Flour / Q000009:adverse effects; D005503:Food Additives / Q000009:adverse effects*; D006968:Hypersensitivity, Delayed / Q000139:chemically induced*; D007074:Immunoglobulin G / Q000032:analysis; D051379:Mice; D011506:Proteins; D012756:Sheep; D013154:Spleen / Q000276:immunology
chemical_list: D000941:Antigens; D005503:Food Additives; D007074:Immunoglobulin G; D011506:Proteins
vernacular_title: Influence de l'alimentation sur l'induction d'une hypersensibilité de type retardé chez la souris.