XO/XY mosaicism and non-fluorescing Y chromosome in a male.
An adult male of short stature and with underdeveloped external genitalia is described, who carried out a number of sexual assaults on young women. He proved to have XO/XY mosaicism and a non-fluorescing Y chromosome. It was considered to be a terminal deletion on morphological grounds. It is suggested, on the evidence of the small number of XO/XY mosaics examined by appropriate staining methods, that an abnormal Y chromosome, whether terminally deleted or non-fluorescing owing to an altered chemical state, predisposes to anaphase lagging and non-disjunction. Of eleven reported cases of XO/XY mosaicism with a non-fluorescing Y chromosome, this is the fifth of male phenotype. The severe behaviour disturbance of early onset is considered to be probably causally associated with the chromosome anomaly.
D002872:Chromosome Deletion; D006801:Humans; D008297:Male; D008875:Middle Aged; D009030:Mosaicism; D010262:Paraphilic Disorders; D010641:Phenotype; D012730:Sex Chromosomes; D014998:Y Chromosome