Lymphatic network of kidney. II. Effect of diuretics on intrarenal renin release.
The individual effects of chlorothiazide, furosemide, and mannitol on renin activity in renal lymph have been studied in dogs. Elevation of renin activity in lymph is noted following infusion with either chlorothiazide or furosemide, while a reduction of renin activity in renal lymph is noted after mannitol infusion. The importance of elevated sodium levels in the proximal end of the distal tubule and its effects on renin release in kidney interstitium is stressed. More work is advocated to elucidate fully the role of renin when released intrarenally.
D000803:Angiotensin I / Q000097:blood / Q000378:metabolism; D000818:Animals; D002740:Chlorothiazide / Q000494:pharmacology; D004232:Diuretics / Q000494:pharmacology*; D004285:Dogs; D005665:Furosemide / Q000494:pharmacology; D007606:Juxtaglomerular Apparatus / Q000187:drug effects / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D007686:Kidney Tubules, Distal / Q000187:drug effects / Q000378:metabolism; D008208:Lymphatic System / Q000378:metabolism*; D008353:Mannitol / Q000494:pharmacology; D012083:Renin / Q000097:blood / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism
D004232:Diuretics; D008353:Mannitol; D002740:Chlorothiazide; D005665:Furosemide; D000803:Angiotensin I; D012964:Sodium; D012083:Renin