Age-dependent response of lactate dehydrogenase of pituitary of rat to testosterone.
The effects of time and various doses of testosterone on the responsiveness of lactate dehydrogenase of pituitary of 7-, 38- and 78-week-old rats were studied. The activity of the enzyme increases in 78-week-old rats. Castration decreases the enzyme activity at all ages. Maximum increase in the enzyme activity is seen with 50 and 100 microgram of testosterone 4 h after administration of hormone to castrated rats. No further time and dose-dependent effect is observed. The magnitude of increase for the enzyme is higher at the age of 38 weeks and decreases in 78-week-old rats.
D000375:Aging; D000818:Animals; D002369:Castration; D004790:Enzyme Induction / Q000187:drug effects; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D008297:Male; D010902:Pituitary Gland / Q000201:enzymology*; D051381:Rats; D013739:Testosterone / Q000494:pharmacology*
D013739:Testosterone; D007770:L-Lactate Dehydrogenase