The effects in rats and guinea pigs from six months exposures to sulfuric acid mist, ozone, and their combination.
Rats and guinea pigs were exposed to 0.5 ppm ozone, 10 mg/m3 sulfuric acid mist, or their combination for 6 hrs/day, 5 days/week for six months. Exposure-related microscopic alterations were seen in the lungs of guinea pigs exposed to ozone alone or in combination with sulfuric acid mist. No other microscopic lesions were present in either rats or guinea pigs. No biologically meaningful synergistic effects were noted in animals exposed to the combination of ozone and sulfuric mist.
D000336:Aerosols; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004347:Drug Interactions; D005260:Female; D006168:Guinea Pigs; D008297:Male; D010126:Ozone / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D012137:Respiratory System / Q000187:drug effects / Q000473:pathology; D013045:Species Specificity; D013464:Sulfuric Acids / Q000008:administration & dosage / Q000633:toxicity*; D013997:Time Factors
D000336:Aerosols; D013464:Sulfuric Acids; D010126:Ozone