Human colostral cytotoxicity: I. Antibody-dependent cellular cytotoxicity against Herpes simplex viral-infected cells mediated by colostral cells.
Human colostral cells in combination with antibody were able to destroy Herpes simplex virus-infected cells (Antibody-dependent cellular cytotoxicity--ADCC) while demonstrating very low spontaneous (non-antibody mediated) cytotoxicity (SCT). The colostral cells involved in ADCC required a high effector to target ratio, were mononuclear, adherent and totally inhibited by latex particles. These results demonstrate that a subpopulation of human colostral macrophages can mediate ADCC against virus-infected target cells. The biologic implications of intact colostral cell ADCC and low SCT in regard to protecting the neonate from infection and maternal cell mediated gastrointestinal damage are discussed.
D000920:Antibody-Dependent Cell Cytotoxicity; D002448:Cell Adhesion; D003126:Colostrum / Q000166:cytology* / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D004064:Digestive System / Q000276:immunology; D005260:Female; D006561:Herpes Simplex / Q000276:immunology*; D006801:Humans; D007840:Latex; D008264:Macrophages / Q000276:immunology; D008863:Microspheres; D009000:Monocytes / Q000276:immunology
D007840:Latex