title: A new anti-cancer principle isolated from Gymnosporia rothiana Laws, and its use in attaining cures in L1210 leukaemia in combination with "S" phase sensitive drugs.
abstract: A new anti-cancer drug, code named GCE pending chemical characterization, has been isolated from a plant Gymnosporia rothiana, Laws. In addition to exhibiting good anti-cancer activities, GCE prolongs the "S" phase of cell cycle. This property has been exploited in evolving a new combination chemotherapy schedule with "S" phase sensitive drugs. Cures in L1210 bearing mice have been observed by administering GCE 2 hours prior to administration of "S" phase sensitive drug such as cytosine arabinoside (Ara-C), hydroxyurea (HU) or 5 fluorouracil (5FU).
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D003561:Cytarabine / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005472:Fluorouracil / Q000627:therapeutic use; D006918:Hydroxyurea / Q000627:therapeutic use; D007399:Interphase / Q000187:drug effects; D007939:Leukemia L1210 / Q000188:drug therapy*; D051379:Mice; D010944:Plants
chemical_list: D000970:Antineoplastic Agents; D003561:Cytarabine; D005472:Fluorouracil; D006918:Hydroxyurea