Ovarian and hypothalamic response to sequential increases in the amount of clomiphene administered to the same group of oligomenorrhoeic women.
Ten patients with oligomenorrhoea were investigated using increasing doses of clomiphene citrate in each cycle. The starting dose was 50 mg on day 1 of the cycle for 5 days and was increased by 50 mg per day for 5 days per cycle, to a maximum dose of 200 mg per day. Urinary total oestrogen concentration was measured on Day 1 to 3, 12 to 14 and on Day 21. Peripheral venous plasma concentrations of immunoreactive LH & FSH on Days 1 to 3 and 12 to 14 and the peripheral venous plasma concentration of immunoreactive progesterone on Day 21 were measured. The response to treatment is discussed in relation to hormone levels in the early follicular phase and to the dose of clomiphene administered. No correlation was found between hormone levels in the early follicular phase and increments in oestrogen and LH concentrations at midcycle. On a low dose regime the increment in FSH at midcycle was significantly greater in patients with a normal FSH concentration in the early follicular phase than in those with a low FSH level at this phase in the cycle. The results of treatment with clomiphene were not changed by an increase in dose from 50 mg to 150 mg but an increase to 200 mg significantly reduced the magnitude of response.
D000328:Adult; D000858:Anovulation / Q000188:drug therapy; D002996:Clomiphene / Q000008:administration & dosage* / Q000494:pharmacology; D004967:Estrogens / Q000652:urine*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000652:urine*; D005498:Follicular Phase / Q000187:drug effects; D006801:Humans; D007986:Luteinizing Hormone / Q000652:urine*; D008599:Menstruation Disturbances / Q000188:drug therapy*; D009839:Oligomenorrhea / Q000188:drug therapy* / Q000503:physiopathology; D006080:Ovarian Follicle / Q000187:drug effects; D011374:Progesterone / Q000652:urine
D004967:Estrogens; D002996:Clomiphene; D011374:Progesterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone