The matrix protein gene determines amantadine-sensitivity of influenza viruses.
The genetic composition of several recombinant strains, produced by mixed infection with an amantadine-sensitive and an amantadine-resistant influenza virus, have been compared with their response to amantadine. It is concluded that transfer of resistance or sensitivity to amantadine is determined by a single gene, that coding for the matrix protein.
D000547:Amantadine / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D005814:Genes, Viral; D009980:Influenza A virus / Q000187:drug effects / Q000235:genetics*; D011995:Recombination, Genetic; D014764:Viral Proteins / Q000096:biosynthesis
D014764:Viral Proteins; D000547:Amantadine