title: [Dynamics of humoral immunity indices in patients with the generalized form of meningococcal infection].
abstract: A possibility of using the passive hemagglutination test with meningococcus diagnostic agents of groups A and C for observing the changes in the infectious process was demonstrated. Sera of patients with generalized form of meningococcus infection showed an increase (by the 2nd--3rd week) and a rapid reduction (by the 4th week) of the specific antibodies titres to the levels seen during the first days of the disease. At the remote periods after the disease--in 2 to 5 years--hemagglutinins were revealed in the same titres as in healthy persons (1:10--1:13). Study of physico-chemical nature of antibodies demonstrated that at the early stages of meningococcus infection there formed antibodies referred chiefly to macroglobulins, and at the remote periods (after 3 months)--to microglobulins.
mesh_terms: D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000032:analysis; D000918:Antibody Specificity; D002648:Child; D002675:Child, Preschool; D003289:Convalescence; D006386:Hemagglutination Tests; D006801:Humans; D007109:Immunity; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007223:Infant; D008585:Meningitis, Meningococcal / Q000276:immunology; D008589:Meningococcal Infections / Q000276:immunology*; D008875:Middle Aged; D018805:Sepsis / Q000276:immunology; D013997:Time Factors
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D007075:Immunoglobulin M
vernacular_title: Dinamika pokazateleĭ gumoral'nogo immuniteta u bol'nykh s generalizovannoĭ formoĭ meningokokkovoĭ infektsii.