Functional changes in compensatory hypertrophy of the canine kidney after uninephrectomy.
Kidney weight and renal functional parameters were investigated in dogs 7 to 68 days after uninephrectomy. Average enlargement of the remaining kidney amounted to 35.1%. Renal blood flow (RBF) and glomerular filtration rate (GFR) calculated per 100 g actual kidney weight were identical in the non-hypertrophied controls and in the hypertrophied kidneys, i.e. structural and functional changes were strictly proportional. Calculation of mean nephron parameters (MNRBF and MNGFR) revealed an increase of about 43% in the hypertrophied kidneys, with an appropriate decrease in nephronal vascular resistance. The hypertrophied kidney showed an enhanced responsiveness to mannitol; increased MNRBF under stop flow conditions was due to a pronounced dilatation of the postglomerular vessels. There was no difference between control and hypertrophied kidneys in cortical zonal blood flow, as investigated by the labelled microsphere technique. Increase in parallel-connected cortical resistances towards the inner (juxtamedullary) zones was pronounced.
D000222:Adaptation, Physiological; D000818:Animals; D004285:Dogs; D005260:Female; D005919:Glomerular Filtration Rate; D007668:Kidney / Q000033:anatomy & histology / Q000098:blood supply / Q000502:physiology*; D008297:Male; D009392:Nephrectomy; D009929:Organ Size; D012039:Regional Blood Flow; D014655:Vascular Resistance