title: [Studies on the immune status of melanoma patients: cell-mediated immune reactions in intracutaneous and epicutaneous tests in the lymphocyte transformation test and the leukocyte-migration inhibition test before and during BCG immunotherapy (author's transl)].
abstract: Active immunotherapy with BCG was carried out postoperatively in 22 patients with malignant melanoma. At the beginning and 6 months after treatment cell-mediated immune reactions were checked by both in vivo tests (intracutaneous test with tuberculin and patchtest with DNCB) and in vitro tests (lymphocyte stimulation and leukocyte migration inhibition with tuberculin and DNCB). The results have shown that stimulation of immune response may be obtained by systemic BCG therapy.
mesh_terms: D000328:Adult; D000368:Aged; D001500:BCG Vaccine / Q000627:therapeutic use*; D002464:Cell Migration Inhibition; D004137:Dinitrochlorobenzene; D006801:Humans; D007111:Immunity, Cellular; D007962:Leukocytes / Q000276:immunology; D008213:Lymphocyte Activation; D008545:Melanoma / Q000276:immunology* / Q000628:therapy; D008875:Middle Aged; D011183:Postoperative Complications; D012882:Skin Tests; D014374:Tuberculin Test
chemical_list: D001500:BCG Vaccine; D004137:Dinitrochlorobenzene
vernacular_title: Untersuchungen zum Immunstatus der Melanomkranken. II. Das Verhalten zellvermittelter Immunreaktionen im Intrakutan- und Epikutan-test, im Lymphozyten-Transformations-Test und im Leukozyten-Migrationshemm-Test vor und während der BCG-Immuntherapie.