title: Time dependent changes induced by external perturbations on a low molecular weight RNA.
abstract: The behaviour of a soluble RNA (MW 19,000) extracted from calf thymus was studied in a partially aqueous solvent. A mixture of dioxane and an aqueous solution of 50 mM NaCl (10:1) was used to dissolve the RNA and the slow optical changes of the solution depending on time and RNA concentration were followed. The relaxation of the RNA was measured after a T-jump in the dioxane-NaCl solvent with an addition of 7 mM methyl red at 470 nm. The relaxation time was measured after experiments carried out with different RNA concentration and the rate process appears to be independent of the RNA concentration.
mesh_terms: D004146:Dioxanes; D004563:Electrochemistry; D009690:Nucleic Acid Conformation; D012313:RNA; D012997:Solvents; D013056:Spectrophotometry, Ultraviolet; D013696:Temperature
chemical_list: D004146:Dioxanes; D012997:Solvents; D012313:RNA