Close relation between hypothalamic and cardiac norepinephrine during stress and its role in acute myocardial infarction disrhythmias.
The decrease of the norepinephrine levels in hypothalamus and heart caused by stress is prevented by pargyline and imipramine. Such a decrease in spleen and adrenals is not affected. Chlorpromazine and lithium only prevented the norepinephrine decrease in the spleen. The uptake of H3norepinephrine by isolated atria of guinea-pig increases during anoxia; the change to a normal oxygen situation decreases these norepinephrine levels by more than 50%.
D000311:Adrenal Glands / Q000378:metabolism; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000209:etiology*; D007031:Hypothalamus / Q000378:metabolism*; D008297:Male; D009203:Myocardial Infarction / Q000150:complications / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism* / Q000502:physiology; D011619:Psychotropic Drugs / Q000494:pharmacology; D051381:Rats; D012149:Restraint, Physical; D013154:Spleen / Q000378:metabolism; D013312:Stress, Physiological / Q000378:metabolism*
D011619:Psychotropic Drugs; D009638:Norepinephrine