Inhibition of gamma-aminobutyric acid uptake into astrocytes by pentobarbital.
Pentobarbital (0.5-2mM), but not phenobarbital, was found to inhibit the uptake of gamma-aminobutyric acid into mouse astrocytes in primary cultures up to 45%. This inhibition was additive to a reduction in uptake rate caused by excess potassium. Its possible role in the pharmacological action of pentobarbital is discussed.
D001253:Astrocytes / Q000187:drug effects / Q000378:metabolism*; D002478:Cells, Cultured; D010424:Pentobarbital / Q000494:pharmacology*; D011188:Potassium / Q000502:physiology; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D005680:gamma-Aminobutyric Acid; D010424:Pentobarbital; D011188:Potassium