[Psychopharmacological effects of flutazolam (MS-4101) (author's transl)].
Behavioral effects of Flutazolam (MS-4101), a new derivative of benzodiazepines, was investigated and compared with effects of diazepam in mice and rats. MS-4101 suppressed hyperemotionality in septal rats, fighting behavior in long-term isolated mice and pentylenetetrazol convulsion and potentiated thiopental sleep. These effects of MS-4101 were the same in potency as those of diazepam. MS-4101 was more potent than diazepam in reducing the spontaneous locomotor activity in the open-field test and potentiating the stimulant effect of methamphetamine on locomotor activity. On the other hand, suppression of hyperemotionality in O. B. rats, potentiation of ethanol-induced anesthesia, prevention of maximal electroshock, prevention of strychnine convulsin and muscle relaxant effect of MS-4101 were less potent than in the case of diazepam. MS-4101 had also an anticonflict effect, which was less potent than that seen with diazepam. Suppression of locomotor activity was potentiated by chronic administration of MS-4101, but disappeared with chronic administration of diazepam. MS-4101 inhibited considerably both scratching and head-twitch induced by mescaline in mice. Scratching was increased with small doses of diazepam and decreased with high doses. Head-twitch was decreased with small doses of diazepam and increased with high doses.
D000378:Agonistic Behavior / Q000187:drug effects; D000818:Animals; D000927:Anticonvulsants; D001522:Behavior, Animal / Q000187:drug effects*; D001569:Benzodiazepines / Q000008:administration & dosage / Q000494:pharmacology*; D003220:Conflict, Psychological / Q000187:drug effects; D003975:Diazepam / Q000494:pharmacology; D004357:Drug Synergism; D008124:Locomotion / Q000187:drug effects; D008297:Male; D008635:Mescaline / Q000494:pharmacology; D008694:Methamphetamine / Q000494:pharmacology; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D012890:Sleep / Q000187:drug effects; D012934:Social Isolation
D000927:Anticonvulsants; D001569:Benzodiazepines; D008694:Methamphetamine; D003975:Diazepam; D008635:Mescaline