title: [Behaviour of ATP and lactate in human papillary muscle during profound hypothermia and injection cardioplegia with magnesium-asparatate-procaine (author's transl)].
abstract: In 53 patients with mitral- or aortic-mitral valve disease, the content of ATP and lactate of the papillary muscles resected at the time of valve replacement was investigated at the beginning of ischemic arrest and at the time of reperfusion. Profound body hypothermia (25 degrees C) and injection cardioplegia using magnesium-aspartate-procaine were applied for myocardial protection. In hypertrophic papillary muscles the myocardial ATP content decreased at a slower rate (ATP decay 12% of the initial value after 60 minutes of ischemia) than in normal papillary muscles obtained from patients with isolated mitral stenosis (ATP decay 33% of the initial value after 40 minutes of ischemia). 20% of the patients required temporary inotropic circulatory support postoperatively for 12 to 88 hours. The ATP content of the papillary muscles of these patients differed only little from those, in who no myocardial failure occurred. However the myocardial lactate levels were higher in patients in whom a low cardiac output state evolved.
mesh_terms: D000255:Adenosine Triphosphate / Q000032:analysis*; D002302:Cardiac Output; D003331:Coronary Vessels / Q000187:drug effects; D006321:Heart / Q000187:drug effects / Q000503:physiopathology; D006324:Heart Arrest, Induced / Q000379:methods*; D006349:Heart Valve Diseases / Q000601:surgery*; D006801:Humans; D007036:Hypothermia, Induced; D007511:Ischemia / Q000139:chemically induced; D007773:Lactates / Q000032:analysis*; D010210:Papillary Muscles / Q000032:analysis*; D011343:Procaine / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D007773:Lactates; D011343:Procaine; D000255:Adenosine Triphosphate
vernacular_title: ATP- und Laktatgehalt des menschlichen Papillarmuskels bei tiefer Körperhypothermie und Injektionskardioplegie mit Magnesium-Aspartat-Procain.