Marrow aplasia induced by colchicine. A case report.
A 70 year old male developed marrow aplasia and pancytopenia after receiving 10 mg of colchicine intravenously over a period of 5 days for acute gouty arthritis. Despite a fatal outcome, evidence of recovery of hematopoiesis was observed in the bone marrow 3 days after the last dose of the drug. The pathogenetic mechanism by which colchicine induced marrow aplasia in this patient remains unclear.
D000368:Aged; D000741:Anemia, Aplastic / Q000097:blood / Q000139:chemically induced* / Q000473:pathology; D001772:Blood Cell Count; D001853:Bone Marrow / Q000473:pathology; D003078:Colchicine / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D006073:Gout / Q000188:drug therapy*; D006801:Humans; D008297:Male; D010198:Pancytopenia / Q000097:blood / Q000139:chemically induced* / Q000473:pathology
D003078:Colchicine