[Erythrocyte alteration in long standing labor inhibition with a beta-sympathicomimetic drug (Partusisten) (author's transl)].
The relative flow rate of the red blood cells in a hematocrit of 10% was measured with a 5 mu nuclepore filter system. The influence of Partusisten was determined by the alteration of the red blood cells. The in vitro concentration of 0.1 ng Partusisten/ml blood resulted in a relative improvement of the flow rate, which we also found in normal pregnancies. However, in a vivo concentration of 4 microgram intravenous Partusisten/min for 48 h, the red cell alteration properties decreased. After a greater time interval, the red blood cells alteration was about the same as in the pre-drug level. The uteroplacental perfusion changed in dependence to the concentration of the beta-mimetic drug (Partusisten). The presence of rigid red blood cells can be first seen in the microcirculation impairment. Depending on the concentration of Partusisten, a protective effect on the flow properties of the red blood cells could be achieved, which altered during pregnancy. However, in late gestosis, a lower dosage should be administered than in labor inhibition.
D004912:Erythrocytes / Q000187:drug effects*; D004983:Ethanolamines / Q000494:pharmacology*; D005260:Female; D005280:Fenoterol / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D008433:Mathematics; D008833:Microcirculation / Q000187:drug effects; D010920:Placenta / Q000098:blood supply; D011225:Pre-Eclampsia / Q000188:drug therapy; D011247:Pregnancy; D012212:Rheology; D013997:Time Factors
D004983:Ethanolamines; D005280:Fenoterol
Veränderungen in der Erythrozytendeformierbarkeit unter der Langzeitwehenhemmung mit einem Betamimetikum (Partusisten).