[Changes in the liver following a single administration of 11-H-eicosafluoroundecanoic acid in rats].
A single oral administration of 27 mg 11-H-eicosafluorundecanoic acid/kg of body weight (according to 1/20 of the oral LD50; 0.049 mM) resulted in a long lasting hepatomegaly in male rats. This was accompanied by a decrease of the triglyceride and total lipid levels in blood serum, a temporary increase of the total lipids in the liver, and an increase of the hexobarbital sleeping time, the latter being normalized before the liver/body weight ratio reached the control level. The bromothalein elimination and the S-alanine amino transferase and S-alkaline phosphatase activities were not affected.
D000284:Administration, Oral; D000818:Animals; D004357:Drug Synergism; D005227:Fatty Acids / Q000008:administration & dosage / Q000633:toxicity*; D006529:Hepatomegaly / Q000139:chemically induced; D006591:Hexobarbital / Q000494:pharmacology; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D012890:Sleep / Q000187:drug effects; D014280:Triglycerides / Q000097:blood
D005227:Fatty Acids; D008055:Lipids; D014280:Triglycerides; D006591:Hexobarbital
Leberveränderungen nach einmaliger Gabe von 11-H-Eicosafluorundekansäure an Ratten.