Effect of dichlorvos, administered to the pregnant rabbits, on the colinesterases activity in the progeny.
The influence of dichlorvos on the cholinesterases activity during ontogenic development was investigated in rabbits. Pregnant females were treated per os with DDVP (6 mg/kg/24 hrs) for the last 10 days of pregnancy. In progeny in the blood plasma and in the homogenates of the brain tissue activity of cholinesterases was measured spectrofotometrically according to Ellman method. Method of Karnowsky and Roots [6] in histoenzymatic investigations was followed. The decrease of acetylcholinesterase activity in the brain tissue and the increase of cholinesterase activity in the blood plasma were observed. The changes sustained through whole period of investigation (1-16 day of life). Histochemically the lowered activity of enzymes was localized mainly in the neuropil of: striatum, the Broc's nuclei and rhinencephalon: in the nervous cells of: Ammon's horn, nuclei of thalamus and in neocortex. The results suggest that the brain centers connected with the high CNS function could be influenced by DDVP intoxication during ontogenic development.
D000818:Animals; D001921:Brain / Q000201:enzymology*; D002802:Cholinesterases / Q000097:blood / Q000378:metabolism*; D004006:Dichlorvos / Q000494:pharmacology*; D005260:Female; D005312:Fetal Blood / Q000201:enzymology*; D005333:Fetus / Q000187:drug effects* / Q000201:enzymology; D011247:Pregnancy; D011817:Rabbits
D004006:Dichlorvos; D002802:Cholinesterases