Hemoglobin E trait reexamined: a cause of microcytosis and erythrocytosis.
The current Indochinese resettlement program in the United States has resulted in an increase in the number of persons with hemoglobin E trait. American physicians should be aware of the hematologic expressions of this innocuous condition. The hematologic manifestations of 21 persons with hemoglobin E trait were evaluated. The subjects were of Tai-dam, Vietnamese, Chinese, Laotian, and European origin. These studies showed uniform hematologic manifestations in hemoglobin E trait, characterized by slight microcytosis, by morphologic features resembling those of thalassemia minor, and often by increased erythrocyte count. Hemoglobin instability also was confirmed.
D000293:Adolescent; D000328:Adult; D001208:Asia / Q000208:ethnology; D002648:Child; D002675:Child, Preschool; D004913:Erythrocytes, Abnormal / Q000032:analysis*; D005260:Female; D006446:Hemoglobin E / Q000032:analysis* / Q000235:genetics; D006455:Hemoglobins, Abnormal / Q000032:analysis*; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D011086:Polycythemia / Q000097:blood* / Q000235:genetics
D006455:Hemoglobins, Abnormal; D006446:Hemoglobin E