Investigation into the species-specific deacylation of penta-acetyl-gitoxin.
Penta-acetyl-gitoxin (PAG) shows species-specific deacylation to 16-acetyl-gitoxin (16 AG; I and III) or gitoxin (II and IV) by homogenates of liver and intestinal mucosa of man (I), rabbit (II), guinea-pig (III) and rat (IV), whereas it is degraded into tri- and tetra-acetates by homogenates of guinea-pig myocardium as well as by human blood and serum. The identity of the principal and chloroform-extractable metabolities in human urine after PAG administration with 16-AG has been demonstrated by mass spectrometry.
D000113:Acetyldigoxins / Q000378:metabolism*; D000328:Adult; D000818:Animals; D001711:Biotransformation; D004077:Digoxin / Q000031:analogs & derivatives*; D006168:Guinea Pigs; D006801:Humans; D066298:In Vitro Techniques; D007413:Intestinal Mucosa / Q000378:metabolism; D007536:Isomerism; D008099:Liver / Q000378:metabolism; D013058:Mass Spectrometry; D009206:Myocardium / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D013045:Species Specificity
D000113:Acetyldigoxins; D004077:Digoxin