[Conjunctival alterations by sympathomimetic drugs (author's transl)].
This is the report of two patients, who used eye drops containing adrenergic agents for a relatively long period of time because of conjunctival troubles. The eye drops contained phenylephrine or tetryzoline or naphazoline. As a consequence of the vasoconstriction, the treatment led to an epithelial xerosis in the region of the caruncula and of the neighbouring eyelid edges. The keratinisation resulted in a closure and disappearance of the puncta lacrimalia. Therefore, the application of vasoconstrictive eye drops for a longer period of time is discouraged. Moreover, eye drops with a low concentration of the sympathomimetic agent should be preferred.
D000368:Aged; D003228:Conjunctiva / Q000187:drug effects*; D005141:Eyelid Diseases / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000009:adverse effects; D007767:Lacrimal Duct Obstruction / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D009278:Naphazoline / Q000009:adverse effects; D009883:Ophthalmic Solutions; D010656:Phenylephrine / Q000009:adverse effects; D013566:Sympathomimetics / Q000008:administration & dosage / Q000009:adverse effects*; D013764:Tetrahydronaphthalenes / Q000009:adverse effects; D013997:Time Factors; D014662:Vasoconstrictor Agents; D014985:Xerophthalmia / Q000139:chemically induced
D007093:Imidazoles; D009883:Ophthalmic Solutions; D013566:Sympathomimetics; D013764:Tetrahydronaphthalenes; D014662:Vasoconstrictor Agents; D010656:Phenylephrine; D009278:Naphazoline
Bindehautalterationen durch Sympathomimetika.