title: Cation transport alteration associated with plasmid-determined resistance to cadmium in Staphylococcus aureus.
abstract: Plasmid-determined resistance to cadmium has only been found with plasmids from Staphylococcus aureus. Resistance to cadmium was associated with a lower accumulation of Cd(2+) ions by the plasmid-bearing resistant cells. Cadmium accumulation by susceptible cells was energy dependent and had those characteristics usually associated with a transmembrane active transport system. There was a specific interrelationship between cadmium accumulation and manganese accumulation and retention. Cd(2+) inhibited the uptake of Mn(2+) and accelerated the loss of intracellular Mn(2+) by the susceptible cells, but was without effect on Mn(2+) transport in resistant S. aureus cells. Under similar conditions, there was no differential effect of Cd(2+) on Mg(2+), Zn(2+), Co(2+), Ni(2+), or Rb(+) accumulation or exchange between the susceptible and the resistant strains.
mesh_terms: D001692:Biological Transport; D002104:Cadmium / Q000378:metabolism / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D010957:Plasmids / Q000187:drug effects*; D013211:Staphylococcus aureus / Q000254:growth & development*
chemical_list: D002104:Cadmium