Metaphase arrest in the bone marrow cells of Rattus norvegicus by the Beta-exotoxin of Bacillus thuringiensis.
The beta-exotoxin, thuringiensin A, from Bacillus thuringiensis var. thuringiensis has been found to be C-mitotic in the bone marrow cells of Rattus norvegicus. This exotoxin therefore appears to be a potential tool for metaphase arrest in karyological studies. The delta-endotoxin protein has no similar activity.
D000818:Animals; D001413:Bacillus thuringiensis / Q000502:physiology*; D001427:Bacterial Toxins / Q000494:pharmacology*; D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells; D002453:Cell Cycle / Q000187:drug effects*; D005098:Exotoxins / Q000494:pharmacology*; D008677:Metaphase / Q000187:drug effects*; D051381:Rats
D001427:Bacterial Toxins; D005098:Exotoxins