[Concentration in bone and haematoma of the aminoglycoside antibiotic tobramycin (author's transl)].
Tobramycin concentrations were assayed in the rabbit in serum during surgery and in serum, haematoma and bone tissue of the condyle of the femur in the absence of surgery. After a single i. m. injection serum levels were found to be 30% higher initially than in humans, but then dropped at a faster rate to zero. The hardening haematoma appeared to slow penetration of the antibiotic. The concentration in bone tissue was dependent on vascular supply. Surgery did not show any influence on the level of the concentrations.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis*; D001847:Bone Diseases / Q000097:blood; D004353:Drug Evaluation, Preclinical; D005269:Femur / Q000032:analysis* / Q000293:injuries; D006406:Hematoma / Q000378:metabolism*; D007869:Leg Injuries; D011817:Rabbits; D014031:Tobramycin / Q000032:analysis* / Q000097:blood / Q000378:metabolism
D000900:Anti-Bacterial Agents; D014031:Tobramycin
Knochen- und Hämatomspiegel des Aminoglykosid-Antibiotikums Tobramycin.