Hematological studies in induction of abortion by extra-amniotic administration of sulproston.
The prostaglandin E2 derivative, Sulproston, was administered extra-amniotically for the induction of abortion in an average dosage of 200 microgram, in ten patients. With a success rate of 50%, the subjective side effects were very slight. Temperature, pulse rate, blood pressure and frequently of breathing did not change markedly. The ADP- and collagen-induced platelet aggregation showed a tendency to increase but disaggregation remained the same. Spontaneous platelet aggregation according to Breddin did not change. The parameters examined of the coagulation and fibrinolytic system showed only a slight increase in fibrinolytic activity during and after induction of abortion. The remaining hematological parameters showed no changes.
D000019:Abortifacient Agents / Q000009:adverse effects*; D000293:Adolescent; D000328:Adult; D001777:Blood Coagulation / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects; D011247:Pregnancy; D011459:Prostaglandins E, Synthetic / Q000009:adverse effects*; D011674:Pulse / Q000187:drug effects; D012119:Respiration / Q000187:drug effects
D000019:Abortifacient Agents; D011459:Prostaglandins E, Synthetic