The fetal alcohol syndrome: symptoms and pathogenesis.
The symptoms of the fetal alcohol syndrome and their frequency of appearance are described based on 41 reports in the literature and on own observations. Experimental evidence is presented proving the lack of cytotoxicity, mutagenicity and teratogenicity of alcohol itself and the intensive cytotoxicity, mutagenicity and teratogenicity of acetaldehyde. Responsibility for the fetal alcohol syndrome is ascribed to acetaldehyde at maternal blood concentrations surpassing 35 micrometer and it is suggested that the raised acetaldehyde level is due to an inherited or acquired defect of mitochondrial aldehyde dehydrogenase. Prospective mothers displaying acetaldehyde levels exceeding 30 micrometer after a drink should be advised against bearing a child.
D000014:Abnormalities, Drug-Induced / Q000209:etiology; D000079:Acetaldehyde / Q000097:blood; D000328:Adult; D000445:Aldehyde Oxidoreductases / Q000097:blood; D000818:Animals; D002675:Child, Preschool; D006224:Cricetinae; D000431:Ethanol / Q000097:blood / Q000378:metabolism; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000097:blood / Q000201:enzymology / Q000209:etiology*; D005312:Fetal Blood / Q000201:enzymology / Q000378:metabolism; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008431:Maternal-Fetal Exchange; D008928:Mitochondria / Q000201:enzymology; D009154:Mutation / Q000187:drug effects; D011247:Pregnancy; D051381:Rats
D000431:Ethanol; D000445:Aldehyde Oxidoreductases; D000079:Acetaldehyde