title: Plasma timolol levels after oral and intravenous administration.
abstract: The plasma kinetics of timolol administered orally and intravenously to 5 male subjects were examined. Bioavailability was reduced by 25% when the drug was taken orally. Mean plasma half-life after oral dosing was 4.86 h, and after intravenous administration it was 4.56 h; the difference was not significant. The volume of distribution was 3.5 1/k. It is suggested that timolol is little affected by the 'first pass effect', even though there is marked interindividual variation in availability and peak plasma level.
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D006801:Humans; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D011412:Propanolamines / Q000097:blood*; D013997:Time Factors; D013999:Timolol / Q000008:administration & dosage / Q000097:blood*
chemical_list: D011412:Propanolamines; D013999:Timolol