The significance of nasal protease inhibitor concentrations in house dust allergy.
In 57 patients with house dust allergy and 20 controls protease inhibitor concentrations in nasal secretions were measured before and after antigen challenge. A correlation was found between low inhibitor levels and long duration of disease. Furthermore, significant differences of inhibitor concentrations could be demonstrated between patients with strong or moderate reactions to antigen provocation, and between patients with isolated rhinitis or a combination of rhinitis and bronchial asthma. The clinical significance of the results will be discussed with special regard to different biochemical mechanisms in the pathophysiology of seasonal and perennial immediate-type rhinitis.
D000293:Adolescent; D000328:Adult; D000485:Allergens; D002648:Child; D002675:Child, Preschool; D004391:Dust; D005260:Female; D006801:Humans; D008297:Male; D009297:Nasal Mucosa / Q000378:metabolism*; D011480:Protease Inhibitors / Q000378:metabolism*; D006255:Rhinitis, Allergic, Seasonal / Q000201:enzymology / Q000378:metabolism*
D000485:Allergens; D004391:Dust; D011480:Protease Inhibitors