Corticosterone metabolism and the incorporation of leucine, uridine, and thymidine into fetal mouse brain.
The change in the pattern of biotransformation of [14C]corticosterone in fetal mouse brain between gestational day 14 and 17 increased the proportion of unchanged hormone from 9-75%. A sharp decrease in the in vitro incorporation of [14C]leucine, [3H]uridine, and [3H]thymidine into incubated brain coincided with this change and continued until day 19, when the incorporation of the 3 substrates had fallen to 9, 54, and 16%, respectively, of that on day 14. Injection of dexamethasone reduced values on day 14 to those normally found on days 15-18. Enzymes which metabolize corticosteroids regulate their activity in specific tissues; these data suggest a hormonal influence on developing brain.
D000367:Age Factors; D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000196:embryology* / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects; D002854:Chromatography, Paper; D003345:Corticosterone / Q000378:metabolism / Q000494:pharmacology; D003907:Dexamethasone / Q000494:pharmacology*; D005260:Female; D005333:Fetus / Q000378:metabolism; D007930:Leucine / Q000378:metabolism*; D008297:Male; D051379:Mice; D013936:Thymidine / Q000378:metabolism*; D014529:Uridine / Q000378:metabolism*
D003907:Dexamethasone; D007930:Leucine; D013936:Thymidine; D003345:Corticosterone; D014529:Uridine