Ornithine decarboxylase activity in rat liver during phalloidin poisoning.
Rat liver ornithine decarboxylase activity was measured during phalloidin poisoning of 17 day-old rats, adult rats, and adult rats protected against phalloidin toxicity by pretreatment with somatotropin. The results show: 1. In adult rats, after a short period of activation, ornithine decarboxylase activity decreases to basal levels after phalloidin administration and remains so until death. 2. In somatotropin-pretreated rats, the enzyme activity increases with a peak 4 hours after injection of somatotropin but then drops rapidly to control levels. All rats survive poisoning. In somatotropin-pretreated rats that has also been given the ornithine decarboxylase inhibitor, 1,3-diaminopropane, phalloidin poisoning causes a decrease in the enzyme activity to basal levels and death of all animals. 3. In 17 day-old rats, ornithine decarboxylase activity decreased initially after phalloidin poisoning but then returned to unpoisoned levels. All rats survived poisoning, even those pretreated with 1,3-diaminopropane.
D012437:Adenosylmethionine Decarboxylase / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn; D002262:Carboxy-Lyases / Q000378:metabolism*; D003959:Diamines / Q000494:pharmacology; D005260:Female; D013006:Growth Hormone / Q000494:pharmacology / Q000627:therapeutic use*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D009842:Oligopeptides / Q000506:poisoning*; D009955:Ornithine Decarboxylase / Q000378:metabolism*; D010590:Phalloidine / Q000506:poisoning*; D051381:Rats
D003959:Diamines; D009842:Oligopeptides; D010590:Phalloidine; D013006:Growth Hormone; C009475:trimethylenediamine; D002262:Carboxy-Lyases; D009955:Ornithine Decarboxylase; D012437:Adenosylmethionine Decarboxylase