Proliferative activity of myocardial capillary wall cells in dipyridamole--treated rats.
The hearts of rats treated with dipyridamole were studied by light microscope autoradiography and measurement of tissue radioactivity after intravenous injection of 3H-thymidine. Total tissue radioactivity was significantly increased in the hearts of the dipyridamole-treated animals. Only capillary wall cells were labelled in the autoradiograms. The observations indicate a proliferation of capillary wall cells, suggesting a neoformation of myocardial capillaries during dipyridamole treatment.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002196:Capillaries / Q000166:cytology / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D003331:Coronary Vessels / Q000166:cytology / Q000187:drug effects*; D004176:Dipyridamole / Q000494:pharmacology*; D005260:Female; D006321:Heart / Q000187:drug effects; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats
D004176:Dipyridamole