[Preliminary studies of Conus geographus venom structural properties: evaluation of the toxin's molecular weight].
Venom from the posterior half of the venom duct of Conus Geographus was toxic to mice but without effect on a crab, and produced a flaccid spasmodic paralysis in mice. The minimum lethal dose for mice ranged from 5 micrograms to 50 micrograms (net weight) of venom per mouse. Toxin was submitted to Sephadex G 25 chromatography and to ultrafiltration. The venom was inactivated by pronase. The data suggested that the toxin was a peptide of molecular weight of about 1 500-2 000.
D000818:Animals; D003386:Brachyura / Q000187:drug effects; D004355:Drug Stability; D007928:Lethal Dose 50; D051379:Mice; D008970:Molecular Weight; D008978:Mollusk Venoms / Q000032:analysis* / Q000037:antagonists & inhibitors / Q000633:toxicity; D010455:Peptides / Q000032:analysis; D011402:Pronase / Q000494:pharmacology; D014462:Ultrafiltration
D008978:Mollusk Venoms; D010455:Peptides; D011402:Pronase
Etudes préliminaires des propriétés structurales du venin de Conus geographus: évaluation du poids moléculaire de la toxine.