Tissue distribution of arsenic after subcutaneous implantation of arsenic trioxide pellet in rats.
In control rats, the arsenic level in the spleen and blood cells was 1.59 and 10.79 microgram/g wet tissue, respectively. In the kidney, lung, heart, brain, and hair, the arsenic level was lower than 1.1 microgram/g wet tissue. In rats in which a pellet containing 2 mg of arsenic tsioxide was implanted subcutaneously, the arsenic level in the spleen and blood cells was markedly high for at least 2 months after implantation; after 67 days of implantation, the arsenic level in the spleen and blood cells was 16.79 and 66.34 microgram/g wet tissue, respectively. In the kidney, liver, lung, heart, brain, and hair, the increase in arsenic after implantation was smaller than that in the spleen. In the plasma, arsenic was not detected before and after arsenic implantation. It is concluded that arsenic implanted subcutaneously concentrates in the blood cells, possibly in the red cells, in rats.
D000818:Animals; D001151:Arsenic / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D004343:Drug Implants; D008297:Male; D051381:Rats; D013997:Time Factors; D014018:Tissue Distribution
D004343:Drug Implants; D001151:Arsenic