Acidic glycosaminoglycans in skin and urine of a patient with wide-spreaded lichen sclerosus et atrophicus.
Changes of dermal and urinary acidic glycosaminoglycans in Lichen Sclerosus et Atrophicus (LSA) were investigated with the following results: 1. Hyaluronic acid (HA) was excreted in urine of a patient with LSA. 2. HA and low sulfate chondroitin were eluted with 0.5 M NaCl by Bio Rad AG 1- x 2 (Cl- form) column chromatography. 3. Involved dermal tissue contained only about 50% of HA in the skin of a healthy adult.
D001284:Atrophy / Q000473:pathology; D002845:Chromatography; D004588:Electrophoresis, Cellulose Acetate; D006025:Glycosaminoglycans / Q000032:analysis / Q000302:isolation & purification / Q000378:metabolism*; D006801:Humans; D008010:Lichen Planus / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012594:Scleroderma, Localized / Q000378:metabolism*; D012598:Sclerosis / Q000473:pathology; D012867:Skin / Q000378:metabolism* / Q000473:pathology
D006025:Glycosaminoglycans