title: [Treatment of advanced digestive cancer with fluorouracil and methyl-CCNU].
abstract: We relate the experience obtained by treatment of 20 advanced digestive cancer patients, with the association of 5 fluorouracil and methyl-C.C.N.U. Objective response was found in 4 patients (20%). Toxicity consisted of leucopenia in 3 patients, allergic phenomena in 2 and diarrhea in 1 patient. Mean survival is increased in 3 months in responders, when compared with non-responders, although this difference has not statistical value.
mesh_terms: D000328:Adult; D000368:Aged; D004359:Drug Therapy, Combination; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects / Q000627:therapeutic use*; D005770:Gastrointestinal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009607:Nitrosourea Compounds / Q000627:therapeutic use*; D012673:Semustine / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D009607:Nitrosourea Compounds; D012673:Semustine; D005472:Fluorouracil
vernacular_title: Tratamiento del cáncer digestivo avanzado con fluoracilo y metil - CCNU.