"No-effect-level" of malathion (o,o'-dimethyl dithiophosphate of diethyl mervaptosuccinate) in Bubalus bubalis.
An oral dose of 0.5 mg/kg/day malathion continuously administered for one year has been investigated to produce no change in biochemical (RChE, PChE, aspartate- and alanine aminotransferases, blood glucose, serum urea and plasma total proteins) or haematological (Hb, PCV, tRBC and tWBC) parameters and, therefore, considered to be "no-effect-level" in Bubalus bubalis. However, the administration of higher doses (1.0 and 1.5 mg/kg/day) produced significant (P less than 0.05) changes in all biochemical parameters studied. With these doses leucocytosis was evident among haematological parameters measured.
D000818:Animals; D001772:Blood Cell Count; D001786:Blood Glucose / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism; D002020:Buffaloes / Q000378:metabolism*; D002802:Cholinesterases / Q000097:blood; D004305:Dose-Response Relationship, Drug; D008294:Malathion / Q000494:pharmacology*; D013997:Time Factors; D000637:Transaminases / Q000097:blood; D014508:Urea / Q000097:blood
D001786:Blood Glucose; D001798:Blood Proteins; D014508:Urea; D000637:Transaminases; D002802:Cholinesterases; D008294:Malathion