Dextran receptors as immunogens in caries prophylaxis.
1) Immunization of rats with dextran receptors appears to confer resistance to development of caries. 2) A significant negative correlation between antiserum titers and caries scores is observed in immunized rats. 3) Antiserum specific for dextran receptors does not inhibit in vitro adherence of live bacteria in sucrose supplemented media. 4) Free receptors can bind to dextran, thereby inhibiting its ability to induce bacterial agglutination.
D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D003731:Dental Caries / Q000276:immunology / Q000517:prevention & control*; D003911:Dextrans; D007114:Immunization; D051381:Rats; D011955:Receptors, Drug / Q000276:immunology* / Q000302:isolation & purification; D013295:Streptococcus mutans / Q000276:immunology*
D000907:Antibodies, Bacterial; D003911:Dextrans; D011955:Receptors, Drug