title: Logistics of study on hormone therapy in the climacteric.
abstract: The practical implications of conducting a prospective study into the effects of hormone replacement therapy (HRT) in peri- and post-menopausal women are discussed. The minimum number of woman-years of observation required to yield data of statistical significance is around 50,000, which would involve the participation of 1000 general practitioners.
mesh_terms: D002979:Climacteric / Q000187:drug effects*; D011307:Drug Prescriptions; D005194:Family Practice; D005260:Female; D006728:Hormones / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D011446:Prospective Studies; D012107:Research Design
chemical_list: D006728:Hormones