Salivary IgA antibodies to antigens from Streptococcus mutans in human dental caries.
1) Subjects of low caries experience (DMF 7) had significantly lower IgA antibody titers to antigens from S. mutans serotype c than subjects of high caries experience (DMF 13). 2) Subjects with carious lesions and a high DMF had significantly lower salivary antibody titers than subjects without carious lesions. 3) Sequential studies revealed that in the absence of caries salivary antibody titers decreased over a 9 month period. 4) Treatment of caries was associated with a rise in salivary IgA antibodies. No significant changes were associated with the development of caries. 5) No relationship with caries experience was found with antibodies to S. mutans BHT (serotype b), S. sanguis OMZ-9 or S. mitis CHT. 6) The results do not support the hypothesis that salivary antibodies in man play a role in protection against caries.
D000907:Antibodies, Bacterial / Q000032:analysis*; D002473:Cell Wall / Q000276:immunology; D003731:Dental Caries / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D010306:Parotid Gland; D011135:Polysaccharides, Bacterial / Q000276:immunology; D012463:Saliva / Q000276:immunology*; D012635:Secretory Component / Q000032:analysis; D013295:Streptococcus mutans / Q000276:immunology*; D013997:Time Factors
D000907:Antibodies, Bacterial; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D011135:Polysaccharides, Bacterial; D012635:Secretory Component