Susceptibility of influenza A viruses to amantadine is influenced by the gene coding for M protein.
Influenza A virus recombinants derived from "resistant" and "sensitive" parental viruses were examined for susceptibility to inhibition by amantadine. Correlation of gene constellation and amantadine susceptibility revealed that the gene coding for M protein influences sensitivity or resistance to amantadine. All recombinants which derived an M protein from an amantadine-resistant parent were found to be resistant to amantadine. All amantadine-sensitive recombinants derived an M gene from the amantadine-sensitive parent. However, a few amantadine-resistant recombinants which derived an M gene from the sensitive parent were also isolated, suggesting that the expression of amantadine sensitivity in these recombinants may be influenced by other genes.
D000547:Amantadine / Q000494:pharmacology*; D005814:Genes, Viral; D006389:Hemagglutinins, Viral / Q000235:genetics; D009980:Influenza A virus / Q000187:drug effects* / Q000235:genetics; D009154:Mutation; D009439:Neuraminidase / Q000235:genetics; D011995:Recombination, Genetic; D014764:Viral Proteins / Q000235:genetics*
D006389:Hemagglutinins, Viral; D014764:Viral Proteins; D000547:Amantadine; D009439:Neuraminidase