Anaerobic susceptibility tests. Evaluation of the stability of antimicrobials in Wilkens-Chalgren broth and the effect of media prereduction.
The stability of eight antimicrobial agents in WILKENS-CHALGREN broth was evaluated. The activities of only carbenicillin and benzyl penicillin were significantly decreased after storage for eight weeks at--20 degrees C. Anaerobic reduction of the susceptibility testing broth prior to inoculation was found to be unnecessary.
D000693:Anaerobiosis; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001441:Bacteroides fragilis / Q000187:drug effects; D003470:Culture Media; D004355:Drug Stability; D008826:Microbial Sensitivity Tests / Q000379:methods*; D010084:Oxidation-Reduction; D010460:Peptococcus / Q000187:drug effects; D013997:Time Factors
D000900:Anti-Bacterial Agents; D003470:Culture Media