Diuretic effect of a combined preparation of frusemide and slow-release potassium chloride.
An open randomized crossover study was carried out in 10 healthy volunteers to compare the diuretic effect of a single tablet combining 40 mg frusemide and a slow-release formulation of 600 mg potassium chloride with that of the two agents given in separate tablets. The results showed that both treatments had a similar effect on urinary volume and on sodium and potassium excretion, but the hourly urinary volumes during the first 6 hours suggested that the diuretic action of the combined formulation occurred slightly earlier after administration.
D000328:Adult; D003692:Delayed-Action Preparations; D004232:Diuretics; D004338:Drug Combinations; D005665:Furosemide / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D008297:Male; D011188:Potassium / Q000652:urine; D011189:Potassium Chloride / Q000008:administration & dosage / Q000494:pharmacology*; D012964:Sodium / Q000652:urine; D013997:Time Factors
D003692:Delayed-Action Preparations; D004232:Diuretics; D004338:Drug Combinations; D011189:Potassium Chloride; D005665:Furosemide; D012964:Sodium; D011188:Potassium