Carrageenan oedema in copper-deficient rats.
Carrageenan-induced hind paw oedema has been studied in rats deprived of copper for different lengths of time. A common feature observed in normally fed and copper-deficient rats was the rise of serum copper levels occurring between 10 and 24 h after the injection of the irritant. After 1 month of copper-deficient diet no differences are seen in the oedema developed by controls and copper-deprived animals, while after 3 months the oedema developed by copper-deficient rats was significantly greater compared with the controls.
D000818:Animals; D002351:Carrageenan; D003300:Copper / Q000097:blood / Q000172:deficiency*; D004032:Diet; D004487:Edema / Q000097:blood / Q000139:chemically induced / Q000503:physiopathology*; D005260:Female; D051381:Rats; D013997:Time Factors
D003300:Copper; D002351:Carrageenan