title: [Uptake of peroxidase by activated nerve cells of the hypothalamus (author's transl)].
abstract: After thirst or adrenalectomy followed by dehydration electron microscopy reveals an activation and an increased uptake of peroxidase in the nerve cells of the supraoptic, paraventricular, ventromedial and praemamillar nuclei. The amount of peroxidase which is taken up runs parallel with the activation of the corresponding nerve cells. After rehydratation the activity of the nerve cells and the uptake of peroxidase decrease. The incorporation of the enzyme by the nerve cells differs depending on the region investigated: After thirst peroxidase is taken up especially by the nerve cells of the supraoptic and paraventricular nuclei. After adrenalectomy, however, this is true for the ventromedial and praemamillar nucleus. In the magnocellular nuclei peroxidase is preferentially incorporated by the perikarya, whereas in the parvocellular nuclei the uptake of the enzyme predominates in the dendrites. Within the nerve cells peroxidase is only seen in heterophagic bodies. The ependyma above the paraventricular nucleus takes up peroxidase in low amounts via the cell membrane which borders the III. ventricle; high amounts are incorporated by the lateral and basal plasmalemma.
mesh_terms: D000818:Animals; D003681:Dehydration; D007031:Hypothalamus / Q000378:metabolism* / Q000648:ultrastructure; D010544:Peroxidases / Q000378:metabolism*; D051381:Rats
chemical_list: D010544:Peroxidases
vernacular_title: Uber die Aufnahme von Peroxidase durch aktivierte Nervenzellen des Hypothalamus.