title: Atherosclerotic lesions and mechanisms of cerebral ischaemia.
abstract: Main causes of cerebral infarction and focal transient cerebral attacks (TIAs) were evaluated. We distinguish between primary thrombosis, secondary thrombosis, and atherosclerotic embolism (platelet emboli-mixed emboli-atheromatous emboli). As to the haemodynamic significance of atherosclerotic lesions, the stenoses must be very tight, i.e., suppress 80--90% of the arterial lumen, for blood flow to be reduced. In clinical trials such a situation is not common and we rarely have found out that a stenosis has caused an infarct or focal TIA by reducing blood flow.
mesh_terms: D002544:Cerebral Infarction / Q000209:etiology* / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D006801:Humans; D002537:Intracranial Arteriosclerosis / Q000150:complications* / Q000503:physiopathology; D002542:Intracranial Embolism and Thrombosis / Q000150:complications* / Q000503:physiopathology; D002546:Ischemic Attack, Transient / Q000209:etiology* / Q000503:physiopathology