Influence of the cysteine derivatives on the cell-mediated immunity.
The immunosuppressive action of N,N, S-trimethyl-cysteine, S-methyl-L-cysteine hydrazide hydrochloride and L-cysteine hydrazide on the course of post-adjuvant polyarthritis, graft-versus-host reaction, turpentine oedema and incorporation of 3H-thymidine into spontaneous or PHA stimulated lymphocyte cultures was examined. Inhibition of post-adjuvant polyarthritis and prolongation of skin allograft survival time were observed. L-cysteine hydrazide had shown the most inhibiting action. In vitro, S-methyl-L-cysteine hydrazide hydrochloride decreased and N,N, S-trimethyl-cysteine increased the incorporation of 3H-thymidine into the lymphocyte cultures stimulated by PHA. The obtained results were compared with the action of DL-cysteine hydrochloride.
D000818:Animals; D001168:Arthritis / Q000276:immunology*; D001169:Arthritis, Experimental / Q000276:immunology* / Q000517:prevention & control; D003545:Cysteine / Q000031:analogs & derivatives / Q000494:pharmacology*; D005260:Female; D007111:Immunity, Cellular / Q000187:drug effects*; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D051381:Rats; D013329:Structure-Activity Relationship
D007166:Immunosuppressive Agents; D003545:Cysteine