title: Highlights on the etiology of keloid.
abstract: The keloid phenomenon is old and perplexing. Many hypotheses were advanced to account for keloid growth but none of them provided a satisfactory explanation for the clinical manifestations of the disease. To solve the mystery of keloid detailed clinical studies coupled with laboratory tests were undertaken on keloid and non-keloid individuals; these highlighted the determinants of the disease and paved the way to the formulation of the Sebum Auto-immune Theory. The latter provided valid explanations for the clinical manifestations of the disease and indicated a rationale for new trends of management.
mesh_terms: D001327:Autoimmune Diseases / Q000276:immunology / Q000473:pathology; D006801:Humans; D007428:Intradermal Tests; D007627:Keloid / Q000209:etiology* / Q000276:immunology* / Q000473:pathology; D012627:Sebaceous Glands / Q000473:pathology