Inhibition of gamma-aminobutyric acid release from rat cerebral cortex slices by barbiturate anesthesia.
Amobarbital and pentobarbital anesthesia inhibited the potassium-stimulated, Ca-dependent release of gamma-aminobutyric acid (GABA) from rat cerebral cortex slices during incubation in vitro. Inhibition of GABA release was not found when slices were prepared from rats shortly after they awakened from amobarbital anesthesia. Phenobarbital anesthesia did not affect the release of GABA.
D000596:Amino Acids / Q000378:metabolism; D000654:Amobarbital / Q000494:pharmacology; D000768:Anesthesia, General; D000818:Animals; D001463:Barbiturates / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000378:metabolism*; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D000596:Amino Acids; D001463:Barbiturates; D005680:gamma-Aminobutyric Acid; D000654:Amobarbital; D010424:Pentobarbital; D011188:Potassium