Local Shwartzman-like phenomenon prepared with haptoglobin-hemoglobin complex and provoked with prostaglandin.
Intradermal injection of haptoglobin-hemoglobin (Hp-Hb) complex followed by intravenous injection of prostaglandin (PG) F2a or E2 produced a local Shwartzman-like phenomenon (LSLP) in rabbits, whereas PGE1 has no provoking action. Intradermal injection of hemoglobin or erythrocytes also produced LSLP when provoked with endotoxin or PGF2alpha. The provoking action of endotoxin in the local shwartzman reaction may not be entirely mediated through PGs.
D000818:Animals; D004731:Endotoxins / Q000494:pharmacology; D006242:Haptoglobins / Q000494:pharmacology*; D006454:Hemoglobins / Q000494:pharmacology*; D007213:Indomethacin / Q000494:pharmacology; D007271:Injections, Intradermal; D011453:Prostaglandins / Q000494:pharmacology*; D011458:Prostaglandins E / Q000494:pharmacology; D011460:Prostaglandins F / Q000494:pharmacology; D011817:Rabbits; D012790:Shwartzman Phenomenon / Q000097:blood*
D004731:Endotoxins; D006242:Haptoglobins; D006454:Hemoglobins; D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; D007213:Indomethacin