[Laboratory and clinical study of biological activity of poly G-poly C complex].
Poly(G).poly(C) inoculated intravenously to mice in a dose of 100 microgram induced interferon in the blood in amounts comparable to those induced by poly(I).poly (C). In contrast to rapid accumulation (within 2 hours after induction) and rapid disappearance of interferon in response to poly(I).poly(C) inoculation, the interferon induced by poly(G).poly(C) reached the maximum titer by 6 hours and remained at a high level for 24 hours after inoculation. When given to human volunteers intranasally in a dose of 6 mg, the poly(G).poly(C) complex induced interferon in the blood serum in 70% of the subjects in a titer of 85 units/ml within 24 hours.
D000281:Administration, Intranasal; D000293:Adolescent; D000328:Adult; D000818:Animals; D006801:Humans; D007275:Injections, Intravenous; D007369:Interferon Inducers / Q000494:pharmacology*; D007372:Interferons / Q000096:biosynthesis*; D051379:Mice; D011066:Poly C / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D011068:Poly G / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D011070:Poly I-C / Q000494:pharmacology / Q000633:toxicity; D011131:Polyribonucleotides / Q000494:pharmacology*
D007369:Interferon Inducers; D011131:Polyribonucleotides; D011068:Poly G; D011066:Poly C; D007372:Interferons; D011070:Poly I-C
Laboratornoe i klinicheskoe issledovanie biologicheskoĭ aktivnosti kompleksa poli(G).poli(Ts).