title: [Effect of 2-(5-methyl-4-imidazolyl)-1-methylethylamine on histamine receptors].
abstract: Compound 2-(5-methyl-4-imidazolyl)-1-methylethylamine was tested on different preparations for its histamine-like activity. It was found to markedly affect H2 receptors and at the same time to be practically devoid of any activity on H1 receptors. This high selectivity of action indicates that this compound may represent a useful tool for characterizing the distribution of H2 and H1 receptor sites.
mesh_terms: D000403:Airway Resistance / Q000187:drug effects; D000818:Animals; D002415:Cats; D005260:Female; D005704:Gallbladder / Q000187:drug effects; D005750:Gastric Juice / Q000378:metabolism; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D007093:Imidazoles / Q000494:pharmacology*; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D051381:Rats; D011968:Receptors, Histamine / Q000187:drug effects*; D011969:Receptors, Histamine H1 / Q000187:drug effects; D011970:Receptors, Histamine H2 / Q000187:drug effects; D014590:Uterine Contraction / Q000187:drug effects
chemical_list: D007093:Imidazoles; D011968:Receptors, Histamine; D011969:Receptors, Histamine H1; D011970:Receptors, Histamine H2
vernacular_title: Azioni della 2-(5-metil-4-imidazolil)-1-metiletilamina sui recettori istaminici.