Alpha tocopherol and blood pressure in PN/n mice.
The tail cuff blood pressure of PN/n mice, previously studied for arteritis and glomerulitis, was found to be raised before histological changes appeared. The pressure of mice bred for two generations on a diet containing a low level of alpha tocopherol (E) fell to that of control CBA mice. Replacement of E in the diet, or by intraperitoneal injection, led to a rise of pressure. The pressure reached a mean of 150 mm/Hg after breeding the mice for a further three generations on a more complete diet with additional E. An inhibitory effect of E on prostaglandin production was postulated. E had no effect on the pressure of CBA/MAC mice.
D000818:Animals; D001167:Arteritis / Q000503:physiopathology; D001794:Blood Pressure / Q000187:drug effects*; D004032:Diet; D007267:Injections; D051379:Mice; D008815:Mice, Inbred Strains; D014810:Vitamin E / Q000008:administration & dosage / Q000494:pharmacology*
D014810:Vitamin E