The effect of phenylthiocarbamide (PTC) on mouse brain development.
PTC--when dispensed during the whole fetal development--causes a disturbance of brain development in new born mice. This disturbance in manifested by a reduction of the cell number, a reduced protein content and a reduced activity of acetylcholinesterase in the brain.
D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000196:embryology* / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D004805:Ependyma / Q000187:drug effects / Q000196:embryology; D051379:Mice; D009419:Nerve Tissue Proteins / Q000378:metabolism; D010670:Phenylthiourea / Q000494:pharmacology*; D012313:RNA / Q000378:metabolism; D013974:Thyroxine / Q000037:antagonists & inhibitors
D009419:Nerve Tissue Proteins; D012313:RNA; D010670:Phenylthiourea; D004247:DNA; D000110:Acetylcholinesterase; D013974:Thyroxine