[Animal experiment evaluation of myocardial protection with a magnesium-asparaginate-procaine solution].
Cardioplegic myocardial protection with magnesium asparaginate procaine (Cardioplegin) is assessed in normothermic ischemia by left ventricular function curves. Different ischemic times (20, 30, 40, and 50 min) and different doses of Cardioplegin (2, 4, and 6 ml/kg) were studied in 68 mongrel dogs. Postischemic myocardial function was depressed in all experiments. However, in the Cardioplegin groups all animals showed signs of recovery and a significant, but not dose-related, hemodynamic improvement compared to the controls.
D000818:Animals; D001216:Asparagine / Q000008:administration & dosage / Q000494:pharmacology*; D004285:Dogs; D004338:Drug Combinations; D006321:Heart / Q000187:drug effects*; D006324:Heart Arrest, Induced; D007511:Ischemia / Q000517:prevention & control; D011343:Procaine / Q000008:administration & dosage / Q000494:pharmacology*; D013012:Sorbitol / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
D004338:Drug Combinations; D011343:Procaine; D013012:Sorbitol; D001216:Asparagine
Tierexperimentelle Beurteilung des Myokardschutzes mittels Magnesium-asparaginat-procain-Lösung.