Suppression of humoral immune response in mice by administration of high molecular levan.
High molecular levan, a polyfructoside, has a dose-dependent inhibitory effect on the primary immune response to sheep red cells (SE) in Balb/c mice, when given as from 1--2 days prior to the antigen injection. A slight stimulation of the immune response was observed when levan was given shortly before or 1 day after the antigen.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004306:Dose-Response Relationship, Immunologic; D004912:Erythrocytes / Q000276:immunology; D005630:Fructans / Q000494:pharmacology*; D006388:Hemagglutinins / Q000096:biosynthesis; D007165:Immunosuppression Therapy; D008297:Male; D051379:Mice; D008970:Molecular Weight; D011134:Polysaccharides / Q000494:pharmacology*; D013154:Spleen / Q000276:immunology; D013997:Time Factors
D005630:Fructans; D006388:Hemagglutinins; D011134:Polysaccharides