Changes of beta-glucuronidase activity in peripheral blood lymphocytes in rats exposed to a mixture of nitrogen oxides and chlorine.
The activity of beta-glucuronidase (BG) was tested cytochemically in the lymphocytes of peripheral blood of rats exposed to a mixture of nitrogen oxides (1.22 mg/m3) and chlorine (1.02 mg/m3) for 12 weeks. The number of lymphocytes was reduced, the activity of BG was depressed and the enzyme was shifted from the lysosomes to the cytoplasm of these cells. A relation between the changes in the lymphocytes at the subcellular level and the immunological responses of the organism are discussed.
D000818:Animals; D002713:Chlorine / Q000494:pharmacology*; D005966:Glucuronidase / Q000097:blood*; D008214:Lymphocytes / Q000201:enzymology* / Q000648:ultrastructure; D008247:Lysosomes / Q000201:enzymology; D008297:Male; D009589:Nitrogen Oxides / Q000494:pharmacology*; D051381:Rats; D013347:Subcellular Fractions / Q000201:enzymology; D013997:Time Factors
D009589:Nitrogen Oxides; D002713:Chlorine; D005966:Glucuronidase