Tumor immunity to murine plasma cell tumours. Influence of responder genotype on the specificity of the immune response to plasmacytomas and T lymphomas.
A tumour-associated antigen has been identified which is expressed on both BALB/c plasmacytomas and T lymphomas, but which does not induce a detectable cell-mediated immune response in the strain of origin of the tumours. The (BALB/c x C57BL) F1 hybrid, however, makes a readily detectable response both in vivo and in vitro in vitro experiments with various BALB/c H-2 F1 cogenic mice indicated that the genetic control of the response was not H-2 linked, and was associated with other C57BL genes.
D000818:Animals; D000951:Antigens, Neoplasm / Q000235:genetics*; D003429:Cross Reactions; D003433:Crosses, Genetic; D003601:Cytotoxicity Tests, Immunologic; D005838:Genotype; D006649:Histocompatibility Antigens / Q000032:analysis; D007109:Immunity; D007114:Immunization; D008223:Lymphoma / Q000235:genetics / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009374:Neoplasms, Experimental / Q000235:genetics / Q000276:immunology; D010954:Plasmacytoma / Q000235:genetics / Q000276:immunology*; D013953:Thymus Neoplasms / Q000235:genetics / Q000276:immunology*
D000951:Antigens, Neoplasm; D006649:Histocompatibility Antigens