Quantitative GLC determination of oxycodone in human plasma.
A GLC assay was developed for the determination of oxycodone levels in human plasma using a nitrogen-specific detector. The assay was developed for use in bioavailability studies of therapeutic doses of oxycodone. After ingestion of a commerical tablet containing 4.5 mg of oxycodone hydrochloride and 0.38 mg of oxycodone terephthalate by six volunteers, the mean peak oxycodone concentration in plasma was 18.4 ng/ml at 1 hr.
D000328:Adult; D002849:Chromatography, Gas; D003061:Codeine / Q000031:analogs & derivatives*; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D008722:Methods; D010098:Oxycodone / Q000097:blood*
D010098:Oxycodone; D003061:Codeine