Mucosal protection during irradiation of exteriorized rat ileum. Effect of hypoxia induced by starch microspheres.
Transient hypoxia induced by intra-arterial injection of degradable starch microspheres was used for protection of exteriorized segments of the rat ileum. Microscopic evaluation of the injury to the mucosa gave a dose modification factor of 0.44 +/- 0.04, which corresponds to an oxygen enhancement ratio of 2.30. A similar factor was also found from measurements of the mucosal weight. No significant development of mucosal oedema could be demonstrated, neither in protected nor in non-protected segments.
D000818:Animals; D000860:Hypoxia; D007082:Ileum / Q000473:pathology / Q000528:radiation effects; D007413:Intestinal Mucosa / Q000098:blood supply / Q000473:pathology / Q000528:radiation effects*; D007421:Intestine, Small / Q000098:blood supply / Q000528:radiation effects*; D008297:Male; D008863:Microspheres; D009929:Organ Size / Q000528:radiation effects; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011835:Radiation Protection; D051381:Rats; D013213:Starch
D013213:Starch