Inhibition of passive anaphylaxis induced in the rat hind paw and peritoneal cavity by N-(2-oxo-3,5,7-cycloheptatrien-1-yl)-aminooxoacetic acid ethyl ester (AY-25,674).
Passive anaphylaxis induced in the rat hind paw and peritoneal cavity with rat serum containing immunoglobulin E antibody was inhibited by N-(2-oxo-3,5,7-cycloheptatrien-1-yl)-aminooxoacetic acid ethyl ester (AY-25,674). In contrast with disodium cromoglycate (DSCG), AY-25,674 was orally active. Otherwise, the activity profile of AY-25,674 was similar to that of DSCG. Peak activity occurred a short time after administration, large doses produced tachyphylaxis, and anaphylactic histamine release from mast cells was inhibited. AY-25,674 did not inhibit increased vascular permeability produced by nonreaginic antibody, compound 48/80, serotonin, or histamine. It is concluded that AY-25,674 produces its antiallergic effects by inhibiting mediator release from mast cells by a mechanism similar to that of DSCG.
D000085:Acetates / Q000494:pharmacology*; D000625:Aminooxyacetic Acid / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000633:toxicity; D000707:Anaphylaxis / Q000503:physiopathology*; D000818:Animals; D003508:Cycloheptanes / Q000494:pharmacology* / Q000633:toxicity; D007073:Immunoglobulin E / Q000276:immunology; D007928:Lethal Dose 50; D008297:Male; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects*; D010567:Pertussis Vaccine / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D013997:Time Factors
D000085:Acetates; D003508:Cycloheptanes; D010567:Pertussis Vaccine; D000625:Aminooxyacetic Acid; D007073:Immunoglobulin E