[Effect of progesterone and phenylbutazone on bile flow and bile acid excretion in male Wistar rats].
Bile flow and excretion of monohydroxy-, dihydroxy- and trihydroxy bile acids (MBA, DBA and TBA) were estimated after acute and subacute progesterone and phenylbutazone pretreatment in adult male Wistar rats in three one-hour periods. Different pretreatment with sunflower oil did not influence bile flow and excretion of DBA and TBA. MBA were not detected. Different administration of progesterone and phenylbutazone did not significantly change the TBA/DBA ratio. Progesterone administration (50 mg/kg b. w. i. p.) 2 hours before bile sampling increased bile flow and bile acid excretion in the third one-hour period. After 3 days of pretreatment with progesterone (3 X 50 mg/kg b. w. i. p.) bile flow and TBA-excretion were diminished. Phenylbutazone (100 mg/kg b. w. i. p.) increased bile flow and TBA-excretion both after acute and subacute administration.
D000818:Animals; D001646:Bile / Q000187:drug effects / Q000378:metabolism*; D001647:Bile Acids and Salts / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D010653:Phenylbutazone / Q000494:pharmacology*; D011374:Progesterone / Q000494:pharmacology*; D051381:Rats
D001647:Bile Acids and Salts; D011374:Progesterone; D010653:Phenylbutazone
Einfluss von Progesteron und Phenylbutazon auf Gallenfluss und Gallensäurenausscheidung bei männlichen Wistarratten.