An analysis of the mammalian ventricular action potential.
A Hodgkin-Huxley model for ventricular excitation is abstracted from electrophysiological data. A singular perturbation analysis of the 8-dimensional phase portrait of the model characterizes the role of calcium during the plateau phase of the ventricular action potential and demonstrates how the calcium refractory period prevents tetanization.
D000200:Action Potentials; D000818:Animals; D002118:Calcium / Q000378:metabolism / Q000502:physiology; D008322:Mammals; D008954:Models, Biological; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism; D011188:Potassium / Q000378:metabolism / Q000502:physiology; D012964:Sodium / Q000378:metabolism / Q000502:physiology; D016276:Ventricular Function
D012964:Sodium; D011188:Potassium; D002118:Calcium