Effect of repeated injections of iron dextran on the haematological, serological and pathological changes in experimental avian tuberculosis.
Eight intramuscular injections of 200 mg/kg of iron (DFe), given as iron dextran twice weekly in the week before and the three weeks after intravenous infection with about 10(7.5) colony-forming units of Mycobacterium avium, significantly prolonged (by about 11 days) the mean 'time-to-death' of immature male fowl (Gallus domesticus) compared with corresponding regimes using dextran (Dx) only or saline, When a proportion of the birds were examined 21 days after infection many of the abnormalities associated with the disease, including a marked hypochromic anaemia, were less severe in DFe-treated than in the Dx- or saline-treated chicks and there were about 10- to 85-fold fewer viable tubercle bacilli in the liver and spleen of the DFe-treated birds.
D000818:Animals; D002645:Chickens; D007273:Injections, Intramuscular; D007505:Iron-Dextran Complex / Q000008:administration & dosage* / Q000494:pharmacology; D008099:Liver / Q000382:microbiology; D009162:Mycobacterium avium / Q000302:isolation & purification; D013154:Spleen / Q000382:microbiology; D014379:Tuberculosis, Avian / Q000097:blood* / Q000276:immunology / Q000473:pathology
D007505:Iron-Dextran Complex