Disialosyl paragloboside. A novel ganglioside isolated from human kidney.
A ceramide hexasaccharide was purified from the gangliosides of human kidney. Its structure was studied by methylation analysis, neuraminidase treatment, weak acid hydrolysis and chromium trioxide oxidation. The structure is suggested to be a disialosyl derivative of paragloboside: formula: (see text) Data indicating the possible existence of a corresponding trisialosyl derivative are also presented.
D002241:Carbohydrates / Q000032:analysis; D005227:Fatty Acids / Q000032:analysis; D005915:Globosides / Q000032:analysis / Q000302:isolation & purification*; D006028:Glycosphingolipids / Q000302:isolation & purification*; D006801:Humans; D007668:Kidney / Q000032:analysis*; D012794:Sialic Acids; D013110:Sphingosine / Q000032:analysis
D002241:Carbohydrates; D005227:Fatty Acids; D005915:Globosides; D006028:Glycosphingolipids; D012794:Sialic Acids; C018928:disialosyl paragloboside; D013110:Sphingosine