title: Effect of an acute increase of the intravascular pressure on the blood-brain barrier: a comparison between conscious and anesthetized rats.
abstract: Conscious rats and rats under nitrous oxide anesthesia were subjected to blood pressure elevations by injection of epinephrine, bicuculline and amphetamine. Mean arterial pressure was measured from a chronic indwelling cannula in the aorta in awake rats. The protein leakage in the brains was studied using Evans blue and 125IHSA. Conscious animals developed less blood-brain barrier dysfunction than anesthetized ones. The largest difference was obtained with amphetamine and the smallest with epinephrine. Possible explanations to the results are discussed.
mesh_terms: D000662:Amphetamines; D000768:Anesthesia, General; D000818:Animals; D001640:Bicuculline; D001812:Blood-Brain Barrier; D004837:Epinephrine; D006973:Hypertension / Q000139:chemically induced / Q000503:physiopathology*; D008297:Male; D051381:Rats
chemical_list: D000662:Amphetamines; D001640:Bicuculline; D004837:Epinephrine