The final step of side-chain cleavage of cholesterol by adrenocortical cytochrome P-450(scc) studied with [22(-18)O]20,22-dihydroxycholesterols, [18O]isocaproaldehyde, [18O]water and atmospheric [18O]oxygen.
D000302:Adrenal Cortex / Q000201:enzymology*; D000447:Aldehydes / Q000378:metabolism; D000818:Animals; D002208:Caproates / Q000378:metabolism*; D002784:Cholesterol; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D006888:Hydroxycholesterols / Q000378:metabolism*; D013058:Mass Spectrometry; D010100:Oxygen; D010103:Oxygen Isotopes; D014867:Water
D000447:Aldehydes; D002208:Caproates; D006888:Hydroxycholesterols; D010103:Oxygen Isotopes; D014867:Water; C018575:isocaproaldehyde; C003563:20,22-dihydroxycholesterol; D003577:Cytochrome P-450 Enzyme System; D002784:Cholesterol; D010100:Oxygen