Hypodiploidy and serum immunoglobulin concentrations in the elderly.
Chromosome analyses and Ig level determinations were carried out on seventeen aged men and women, 83--100 years of age. In men, significant correlations were found between hypodiploidy and IgA (gamma = 0.95) and between monosomy C and IgG (gamma = 0.79) while in women, monosomy G and IgG were significantly correlated (gamma = 0.73). The emergence of significant correlations between chromosome loss and Ig levels in this study provides support for  a relationship between age-associated chromosomal changes in T cells and the immunologic response of B cells.
D000368:Aged; D000375:Aging; D002869:Chromosome Aberrations; D002906:Chromosomes, Human, 6-12 and X; D004171:Diploidy; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007136:Immunoglobulins / Q000235:genetics*; D008297:Male; D012737:Sex Factors
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins