[Incorporation of S-adenosylmethionine in the isolated and perfused rat liver. Preliminary study].
The uptake of labeled S-adenosylmethionine (SAM) by isolated and perfused rat liver has been compared to that of methionine: the rate of incorporation of the amino acid exceeds by about three times that of the sulfonium compound. S-Adenosylmethionine transport system shows saturation kinetics with an apparent Km of 59,5 microM and is energy-dependent, as demonstrated by the inhibition by 2,4-dinitrophenol.
D000818:Animals; D008099:Liver / Q000378:metabolism*; D008715:Methionine / Q000378:metabolism; D051381:Rats; D012436:S-Adenosylmethionine / Q000378:metabolism*
D012436:S-Adenosylmethionine; D008715:Methionine
Incorporazione della S-adenosilmetionina nel fegato di ratto isolato e perfuso. Studio preliminare.