Monitoring salivary misonidazole in man: a possible alternative to plasma monitoring.
Concentrations of misonidazole and its O-demethylated metabolite Ro 05-9963 in the plasma and saliva of 10 patients with malignant disease have been determined. A good linear correlation was established between plasma and saliva misonidazole concentration, and salivary sampling was found to be suitable for the estimation of a number of pharmacokinetic parameters. Data are also presented for serial tumour cencentrations of misonidazole and Ro 05-9963 in 3 of the 10 patients. Monitoring of salivary misonidazole concentration appears to be a useful alternative to plasma monitoring, particularly for those patients in whom plasma sampling is unsuitable or impossible.
D000328:Adult; D000368:Aged; D001984:Bronchial Neoplasms / Q000032:analysis; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D008920:Misonidazole / Q000032:analysis* / Q000097:blood; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000032:analysis; D009593:Nitroimidazoles / Q000032:analysis*; D012463:Saliva / Q000032:analysis*; D012878:Skin Neoplasms / Q000032:analysis
D009593:Nitroimidazoles; D008920:Misonidazole