Effects in rats and guinea pigs of six-month exposures to sulfuric acid mist, ozone, and their combination.
Rats and guinea pigs were exposed to 0.5 ppm O3, 10 mg/m3 sulfuric acid (H2SO4) mist, or their combination for 6 h/d, 5 d/wk for 6 mo. Microscopic alterations were seen in the lungs of guinea pigs exposed to O3 alone or in combination with H2SO4 mist. No other microscopic lesions were present in either rats or guinea pigs. No biologically meaningful synergistic effects were noted in animals exposed to the combination of O3 and H2SO4 mist.
D000336:Aerosols; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001980:Bronchi / Q000473:pathology; D004347:Drug Interactions; D005260:Female; D006168:Guinea Pigs; D008168:Lung / Q000473:pathology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010126:Ozone / Q000494:pharmacology*; D051381:Rats; D012737:Sex Factors; D013464:Sulfuric Acids / Q000494:pharmacology*; D013997:Time Factors
D000336:Aerosols; D013464:Sulfuric Acids; D010126:Ozone