Studies on morphological changes of arteries by administration of soluble immune complexes to low calcium diet bred guinea pigs.--Special reference to the morphological pathogenesis of arteritis.
Guinea pigs bred on a low calcium diet for 5 weeks, were injected soluble immune complexes once and angitis or angiolytic changes of the vascular wall in the lungs were noted. Leucocytic adhesions along the luminal surface of the vascular wall, which were carved with leucocytic reactions, could be noticed. Loosening or duplication of the basement membrane accompanied by protrusion of vascular smooth muscle cells into the subendothelial space could be demonstrated. Above results are thought to be a consequence of the conjugation of immune complexes and the negative charges of acid mucopolysaccharides.
D000818:Animals; D000936:Antigen-Antibody Complex; D001167:Arteritis / Q000209:etiology / Q000473:pathology*; D001485:Basement Membrane / Q000473:pathology; D002136:Calcium, Dietary; D004727:Endothelium / Q000473:pathology; D005260:Female; D006168:Guinea Pigs; D008168:Lung / Q000473:pathology; D008297:Male; D009130:Muscle, Smooth / Q000473:pathology
D000936:Antigen-Antibody Complex; D002136:Calcium, Dietary