[Anti-rabies vaccination. Comparative analysis of the responses of Flury Hep, Fuenzalida, and inactivated Flury Hep vaccines].
The authors verified the following: The FLURY HEP vaccine, with modified virus, confers a higher level of protection when applied by intracerebral route in laboratory animals. With an equal number of viral particles of FLURY HEP modified virus and fixed virus (FUENZALIDA type vaccine), inoculated intracerebrally and intramusculary, a better protection was obtained with the first kind of vaccine, specially by intracerebral route. These conditions suggest the possibility of replication of modified HEP virus in the cells of the central nervous system. The results show that the concentration of neutralizing antibodies in the serum is not the only responsable for protection, but suggests the possibility of factors or of cellular immunity acting in the animal's protection against rabies.
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D006224:Cricetinae; D006168:Guinea Pigs; D007111:Immunity, Cellular; D051379:Mice; D011818:Rabies / Q000276:immunology; D011819:Rabies Vaccines / Q000008:administration & dosage / Q000276:immunology*; D011820:Rabies virus / Q000302:isolation & purification; D014611:Vaccination; D014779:Virus Replication
D000914:Antibodies, Viral; D011819:Rabies Vaccines
Contribuição ao estudo da vacinação anti-rábica. Análise comparativa das respostas das vacinas Flury Hep, Fuenzalida e Flury Hep inativada.