A history of the Reed-Sternberg cell.
The diagnosis of Hodgkin's disease continues to depend upon the finding of Reed-Sternberg cells in an appropriate histological setting. The cellular origin of the Reed-Sternberg cell is, however, controversial, and the relationship of Hodgkin's disease to the "non-Hodgkin" lymphomas remains uncertain. In the last decade techniques derived from basic immunology have added a new dimension to our understanding of the cellular origin of the "non-Hodgkin" lymphomas. Our concepts of Hodgkin's disease may require modification along similar principles.
D003937:Diagnosis, Differential; D006644:Histiocytes / Q000166:cytology; D006689:Hodgkin Disease / Q000175:diagnosis / Q000276:immunology / Q000473:pathology*; D006801:Humans; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000166:cytology; D008223:Lymphoma / Q000175:diagnosis / Q000473:pathology