Neurotoxicity of organophosphorus pesticides: predictions can be based on in vitro studies with hen and human enzymes.
The comparative inhibitory power of organophosphorus esters in vitro against hen brain acetylcholinesterase and neurotoxic esterase correlates with their comparative effects (death or delayed neuropathy) in vivo. Further comparisons of the in vitro effects seen with hen and human enzymes facilitates extrapolations to the human in vivo situation.
D000818:Animals; D001921:Brain / Q000201:enzymology; D002645:Chickens; D002800:Cholinesterase Inhibitors; D004950:Esterases / Q000037:antagonists & inhibitors*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000139:chemically induced*; D009943:Organophosphorus Compounds
D002800:Cholinesterase Inhibitors; D007306:Insecticides; D009943:Organophosphorus Compounds; D004950:Esterases