[Ultrastructural reactivity of the pulmonary alveoli under the influence of the aerosol use of gentamycin and tetracycline].
Studied is the effect of the aerosol application of the gentamycin and tetracycline antibiotics on the ultrastructure of tung alveoli. It is found that these two antibiotics when applied singly and at doses of 0.3024 mg/rat, 1.728 mg/rat and 12.824 mg/rat for the gentamycin and of 1.652 mg/rat and 3.304 mg/rat for the tetracycline may cause catarrhal pneumonia, accompanied by strong fibrinosis of the alveolar septa and of the alveolar basal membrane. The partial or total lysis of nuclear chromation of all alveolar cell nuclei (epithelial, endothelial, septal, and granulated pneomcytes), the nuclei of the blood granulocytes and macrophages included, is established as a specific ultrastructural change.
D000336:Aerosols; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005839:Gentamicins / Q000008:administration & dosage* / Q000494:pharmacology; D008854:Microscopy, Electron; D011650:Pulmonary Alveoli / Q000187:drug effects* / Q000648:ultrastructure; D051381:Rats; D013752:Tetracycline / Q000008:administration & dosage* / Q000494:pharmacology; D013997:Time Factors
D000336:Aerosols; D005839:Gentamicins; D013752:Tetracycline
Ultrastrukturna reaktivnost na belodrobnite alveoli pod vliianie na gentamitsin i tetratsilin.