[Effect of hyperoxia combined with hydrocortisone administration on respiration of rat brain mitochondria].
After exposure of rats in oxygen atmosphere under pressure of 3 kgs/cm2 within 2 hrs phosphorylating respiration, respiratory control and the ratio ADP/O were decreased, while time of phosphorylation was increased in mitochondria of brain cortex. Content of 11-hydroxycorticosteroids was increased in blood plasma. Reaction of adrenal cortex to hyperbaric oxygenation was inhibited, if hydrocortisone was administered into animals within 1 hr before the treatment; in this case the patterns of mitochondrial function studied were similar to normal values.
D015062:11-Hydroxycorticosteroids / Q000097:blood; D000244:Adenosine Diphosphate / Q000378:metabolism; D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D006854:Hydrocortisone / Q000627:therapeutic use*; D006931:Hyperbaric Oxygenation / Q000009:adverse effects*; D008297:Male; D008928:Mitochondria / Q000378:metabolism*; D010101:Oxygen Consumption; D051381:Rats
D015062:11-Hydroxycorticosteroids; D000244:Adenosine Diphosphate; D006854:Hydrocortisone
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