Effect of verapamil on insulin response to alcohol hypoglycemia in patients with primary hyperparathyroidism.
In hypercalcemic patients with primary hyperparathyroidism who were fasted over a prolonged period, alcohol ingestion induced a significant fall in glucose whereas insulin remained unchanged. The hypercalcemic patients thereby differed from normocalcemic subjects, who showed a significant decline in both glucose and insulin when alcohol was ingested after a prolonged period of fasting. An increased uptake of calcium into the beta-cells appears to have been a prerequisite for the occurrence of an unchanged insulin secretion during alcohol hypoglycemia in hypercalcemic patients, since a calcium-blocking agent, verapamil, infused intravenously during and after alcohol ingestion, brought about a normalization of the insulin response to alcohol hypoglycemia in such patients.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000097:blood / Q000503:physiopathology; D006961:Hyperparathyroidism / Q000097:blood* / Q000503:physiopathology; D007328:Insulin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000378:metabolism; D014700:Verapamil / Q000494:pharmacology*
D001786:Blood Glucose; D007328:Insulin; D000431:Ethanol; D014700:Verapamil; D002118:Calcium