Metastatic Ewing sarcoma to the heart simulating adriamycin cardiotoxicity.
A 20-year-old man with metastatic Ewing Sarcoma developed severe congestive heart failure. Because he had been treated with a large amount of Adriamycin, the diagnosis was initially thought to be Adriamycin cardiotoxicity. However, ante- and post-mortem studies revealed the presence of massive cardiac metastases. At post-mortem, there was no evidence of Adriamycin cardiotoxicity. This case emphasizes that cardiac metastases must be considered in the differential diagnosis of heart failure in patients treated with Adriamycin.
D000328:Adult; D001859:Bone Neoplasms / Q000150:complications*; D003937:Diagnosis, Differential; D004317:Doxorubicin / Q000009:adverse effects* / Q000627:therapeutic use; D006321:Heart / Q000187:drug effects; D006333:Heart Failure / Q000209:etiology*; D006338:Heart Neoplasms; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis; D012512:Sarcoma, Ewing / Q000150:complications*
D004317:Doxorubicin