[Effect of adenosine and inosine on the metabolic status of preserved kidneys].
Isolated rat kidneys were preserved by continuous perfusion or retrograde oxygen persufflation in a medium of the extracellular type with and without addition of adenosine or inosine at 6 degrees C. After 4 and 24 hours of preservation the metabolic states was analysed. In the kidneys preserved by continuous perfusion, only adenosine was able to slow down the loss of nucleotides. With the retrograde oxygen persufflation the stock of high-energy phosphates could be preserved in any case, but no increase in the nucleotide content by neosynthesis was achieved by means of the addition of adenine nucleotide precursors.
D000227:Adenine Nucleotides / Q000378:metabolism*; D000241:Adenosine / Q000494:pharmacology*; D000818:Animals; D003080:Cold Temperature; D007288:Inosine / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009926:Organ Preservation / Q000379:methods*; D010100:Oxygen; D010477:Perfusion; D051381:Rats; D014021:Tissue Preservation / Q000379:methods*
D000227:Adenine Nucleotides; D007288:Inosine; D000241:Adenosine; D010100:Oxygen
Der Einfluss von Adenosin and Inosin auf den Stoffwechselstatus der konservierten Niere.