Toxicological approaches to the metabolites of Fusaria. XIII. Hematological changes in mice by a single and repeated administrations of trichothecenes.
A single or repeated administration of trichothecene mycotoxins to mice induced leukocytosis and leukopenia. Acute and sub-acute toxicosis of trichothecenes was characterized by hematological and pathological observations.
D000818:Animals; D001772:Blood Cell Count; D001777:Blood Coagulation / Q000187:drug effects; D001798:Blood Proteins / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D004798:Enzymes / Q000097:blood; D005670:Fusarium / Q000378:metabolism*; D006402:Hematologic Diseases / Q000139:chemically induced*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009929:Organ Size / Q000187:drug effects; D012717:Sesquiterpenes / Q000633:toxicity*; D013997:Time Factors; D014255:Trichothecenes / Q000633:toxicity*
D001798:Blood Proteins; D004798:Enzymes; D012717:Sesquiterpenes; D014255:Trichothecenes