Hemodynamic effects of methylprednisolone in rats subjected to segmental intestinal ischemia.
Massive doses of methylprednisolone were given to rats subjected to segmental intestinal ischemis. The central and regional blood flows were studied with the microsphere technique. Ischemia was induced by ligating the arteries to 1/4 of the length of the small intestine. In rats subjected to 2 h of segmental intestinal ischemia methylprednisolone seemed to prevent the decrease in blood flow, previously noted in untreated rats, in the regions where the arteries were not occluded. When adequate volume replacement was given in combination with methylprednisolone, the blood flow in the ischemic region showed a slight improvement. The edema in the ischemic segments tended to be less marked in rats treated with methylprednisolone.
D000818:Animals; D001803:Blood Transfusion; D004487:Edema / Q000175:diagnosis; D006439:Hemodynamics / Q000187:drug effects*; D007421:Intestine, Small / Q000098:blood supply*; D007511:Ischemia / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008641:Mesenteric Vascular Occlusion / Q000188:drug therapy* / Q000503:physiopathology; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D008863:Microspheres; D051381:Rats; D014655:Vascular Resistance / Q000187:drug effects
D008775:Methylprednisolone