Virus-associated demyelination. A model using avirulent Semliki Forest virus infection of mice.
Lesions produced by the infection of Swiss/A2G mice with a single inoculation of an avirulent strain of Semliki forest virus have been studied by light and electron microscopy. Whilst a mild encephalitis was detected in the great majority of mice infected, focal areas of myelin loss were observed in the cerebellar white matter of only 25% of cases. The incidence of myelin loss in other strains of mice ranged from 21% in BSVS mice to 8% in SJL/J mice. The possible mechanisms involved in the pathogenesis of the myelin loss are discussed.
D000818:Animals; D001921:Brain / Q000473:pathology* / Q000648:ultrastructure; D003711:Demyelinating Diseases / Q000209:etiology* / Q000473:pathology; D004660:Encephalitis / Q000209:etiology* / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D008815:Mice, Inbred Strains; D008819:Mice, Nude; D012672:Semliki forest virus / Q000472:pathogenicity*; D013045:Species Specificity