title: [Evaluation of some blood clotting parameters in relation to the administration of estroprogestins].
abstract: A number of blood clotting parameters have been determined in the plasma of 25 women who had not previously taken steroid contraceptives. After the administration of an oestroprogestinic association (ethynyloestradiol 0.05 mg + norgestrol 0.25 mg) for five cycles, the same subjects were controlled again for the determination of the same haematochemical parameters. The changes observed highlighted a marked increase in fibrinogenaemia and fibrinolysis, a slight rise in associated clotting factors II-VII-X, no change in the activity of antithrombin III and platelet aggregation.
mesh_terms: D000293:Adolescent; D000328:Adult; D001777:Blood Coagulation / Q000187:drug effects*; D003276:Contraceptives, Oral / Q000009:adverse effects*; D003277:Contraceptives, Oral, Combined / Q000009:adverse effects*; D004997:Ethinyl Estradiol / Q000009:adverse effects*; D005167:Factor VII / Q000032:analysis; D005170:Factor X / Q000032:analysis; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D005342:Fibrinolysis / Q000187:drug effects; D006801:Humans; D009644:Norgestrel / Q000009:adverse effects*; D010974:Platelet Aggregation / Q000187:drug effects; D011516:Prothrombin / Q000032:analysis
chemical_list: D003276:Contraceptives, Oral; D003277:Contraceptives, Oral, Combined; D009644:Norgestrel; D004997:Ethinyl Estradiol; D005167:Factor VII; D011516:Prothrombin; D005170:Factor X; D005340:Fibrinogen
vernacular_title: Valutazione di alcuni parametri emo-coagulativi in rapporto alla somministrazione di estroprogestinici.