Enhanced lethality and tissue levels of chloroquine in rats pretreated with pyrogen.
The lethality, and concentrations of chloroquine in plasma, brain liver and heart, in control and pyrogen-treated rats were investigated. Pyrogen treatment increased the lethality, the convulsive activity, plasma and myocardial concentrations of chloroquine significantly. The results suggest that the initiation of therapy with chloroquine in acute febrile conditions may require smaller than usual dosage.
D000818:Animals; D002738:Chloroquine / Q000378:metabolism / Q000633:toxicity*; D004347:Drug Interactions; D007928:Lethal Dose 50; D008297:Male; D011749:Pyrogens / Q000494:pharmacology*; D051381:Rats; D012119:Respiration / Q000187:drug effects; D012640:Seizures / Q000139:chemically induced; D014018:Tissue Distribution
D011749:Pyrogens; D002738:Chloroquine