Amelioration of cis-platinum nephrotoxicity by orgotein (superoxide dismutase).
In rats, daily administration of subcutaneous dose of 2.5 mg/kg of orgotein, the pharmaceutical preparation of Zn-Cu superoxide dismutase, lowers the nephrotoxicity induced by a 5.0 mg/kg dose of the antitumor agent cis-platinum (cis-diaminedichloroplatinum II). The toxicity of cis-platinum was studied by comparative measurements of blood urea nitrogen and changes in body weight, and by comparative renal histology. In addition to their direct clinical applicability, these results support a role for pathologic levels of oxygen radicals in the etiology of the nephrotoxicity of cis-platinum.
D000818:Animals; D001806:Blood Urea Nitrogen; D001835:Body Weight; D002945:Cisplatin / Q000008:administration & dosage / Q000037:antagonists & inhibitors*; D005260:Female; D007668:Kidney / Q000473:pathology; D007674:Kidney Diseases / Q000097:blood / Q000139:chemically induced* / Q000473:pathology; D051381:Rats; D013482:Superoxide Dismutase / Q000627:therapeutic use*
D013482:Superoxide Dismutase; D002945:Cisplatin