[Research on substances with antiblastic activity. LXI. Synthesis of 6-amino- and 7-amino-9-keto-9H-pyrrolo[1,2-a]indole derivatives].
Intramolecular cyclization of 1-(2-carboxy-4-nitrophenyl)pyrrole afforded 7-nitro-9-oxo-9H-pyrrolo[1,2-a]indole, which was then reduced to 7-amino-9-oxo-9H-pyrrolo[1,2-a]indole. The same procedure was adopted for the synthesis of 6-amino-9-oxo-9H-pyrrolo[1,2-a]indole starting from 1-(2-carboxy-5-nitrophenyl)pyrrole. The preparation of some N-acylderivatives of the above cited aminoketones is reported. These compounds shall be subjected to biological screening against Leukemia L 1210 as a simple analogues of Mitomycin C.
D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D007211:Indoles / Q000138:chemical synthesis*; D008937:Mitomycins / Q000031:analogs & derivatives; D011758:Pyrroles / Q000138:chemical synthesis*
D000970:Antineoplastic Agents; D007211:Indoles; D008937:Mitomycins; D011758:Pyrroles
Ricerche su sostanze ad attività antiblastica. Nota LXI. Sintesi di derivati del 6-amino- e del 7-amino-9-cheto-9H-pirrolo[1,2-a]indolo.