title: [Action of LSD and 5-methoxy-N,N-dimethyltryptamine on the high affinity uptake of [3H]-serotonin by isolated rat brain synaptosomes].
abstract: LSD (10(-7)M--10(-11)M) and 5-methoxy-N,N-dimethyltyptamine (10(-7)--10(-9)M) inhibited the high affinity uptake of [3H]-5HT into synaptosomes. These results suggest that the inhibition of the high affinity uptake is involved in the psychotomimetic action of LSD and 5MeODMT.
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002027:Bufotenin / Q000031:analogs & derivatives* / Q000494:pharmacology; D007700:Kinetics; D008238:Lysergic Acid Diethylamide / Q000494:pharmacology*; D051381:Rats; D012701:Serotonin / Q000031:analogs & derivatives* / Q000378:metabolism*; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism*
chemical_list: D002027:Bufotenin; D012701:Serotonin; D008238:Lysergic Acid Diethylamide
vernacular_title: Wirkung von LSD und 5-Methoxy-N,N-dimethyltryptamin auf die aktive Aufnahme von [3H]-Serotonin in Synaptosomenfraktionen aus Rattenhirn.