Induction of colonic adenocarcinomas by 1,2-dimethylhydrazine intrarectally administered in rats.
Multiple colorectal adenocarcinomas were found in Sprague-Dawley rats after intrarectal injection of 1,2-dimethylhydrazine (DMH). These lesions along with mild hyperplasia of the surrounding mucosa developed within 34 weeks after either 3 or 8 injections of 250 mg DMH/kg body weight.
D000230:Adenocarcinoma / Q000139:chemically induced* / Q000473:pathology; D000818:Animals; D003110:Colonic Neoplasms / Q000139:chemically induced* / Q000473:pathology; D004127:Dimethylhydrazines / Q000008:administration & dosage; D006965:Hyperplasia; D007267:Injections; D007413:Intestinal Mucosa / Q000473:pathology; D008763:Methylhydrazines / Q000008:administration & dosage; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology; D051381:Rats; D012007:Rectum
D004127:Dimethylhydrazines; D008763:Methylhydrazines