Substitution of n-heptane for ethyl ether in USP assay for chlorpromazine hydrochloride in tablets, injections, and sirups.
Peroxide levels above 0.0001% in the ethyl ether used in the USP XIX assay for chlorpromazine hydrochloride in tablets, sirups, and injections produce a distorted spectrophotometric curve in the 350--220 nm region. The use of peroxide-free ethyl ether or n-heptane avoids this problem. Recoveries of 91-100% are obtained with either of these reagents.
D002746:Chlorpromazine / Q000032:analysis*; D004304:Dosage Forms; D004986:Ether; D006536:Heptanes; D012996:Solutions; D012997:Solvents; D013607:Tablets
D004304:Dosage Forms; D006536:Heptanes; D012996:Solutions; D012997:Solvents; D013607:Tablets; D004986:Ether; D002746:Chlorpromazine