title: [Multistage studies aimed at early detection of chronic effects of vinyl chloride and mercury vapors].
abstract: 168 persons occupationally exposed to vinyl chloride and 236 persons exposed to mercury in plants electo two-stage medical and laboratory examinations. Workers exposed to vinyl chloride in average concentrations of 133 mg/m3 were found to show megalohepatia and abnormal enzymatic tests results (transaminic, A1AT, AP). The frequency of disturbances in workers exposed to vinyl chloride, average concentration 17.9 mg/m3, was considerably lesser. The second stage of studies involved those exposed to vinyl chloride for more than 10 years, with megalohepatia and at least 1 abnormal enzymatic test. No angiosarcoma was found. An analysis of the diagnostic value of biological tests used, indicated a great usability of liver scintigraphy and vascular system examinations for early diagnosis of vinyl chloride intoxications. In the plant where workers were exposed to mercury the Hg concentrations were found to range from 0.05 to 0.07 mg/m3. No significant differences between these workers and the control group were found, in respect to medical and laboratory examinations. The second stage of studies involved 118 persons exposed to mercury in concentrations above 20 mg/m3 of air, no matter how long the exposure lasted. The second stage of studies consisted of extensive biochemical studies, examinations of the liver using isotopic scintigraphy, psychological, psychiatric examinations and encephalographic determinations. Psychological, psychiatric and encephalographic examinations were said to be of great importance in early diagnosis of chronic mercury intoxications.
mesh_terms: D000388:Air / Q000032:analysis; D000393:Air Pollutants / Q000506:poisoning; D006529:Hepatomegaly / Q000175:diagnosis; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging; D008628:Mercury / Q000032:analysis; D008630:Mercury Poisoning / Q000175:diagnosis*; D011877:Radionuclide Imaging; D013997:Time Factors; D014752:Vinyl Chloride / Q000032:analysis / Q000506:poisoning*; D014753:Vinyl Compounds / Q000506:poisoning*
chemical_list: D000393:Air Pollutants; D014753:Vinyl Compounds; D008628:Mercury; D014752:Vinyl Chloride
vernacular_title: Zastosowanie modeli wieloetapowych badań dla wczesnego wykrywania skutków przewlekłego działania par chlorku winylu i rteci.