[Pharmacokinetics and bioavailability of naftidrofuryl capsules in man].
We have studied the pharmacokinetics of a single dose of naftidrofuryl in man. Two phases of diffusion have been observed, 11,0 +/- 2,6 respectively 26,5 +/- 3,61. This indicates that the drug is not extensively bound to tissues but mainly distributed throughout the extracellular space. The bioavailability of its oral form, gelatin capsules, is good, if in the same person the area under the plasma curves after oral administration is compared to the one after intravenous injection.
D001682:Biological Availability; D002214:Capsules; D005260:Female; D005663:Furans / Q000378:metabolism*; D006801:Humans; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D009257:Nafronyl / Q000008:administration & dosage / Q000378:metabolism*
D002214:Capsules; D005663:Furans; D009257:Nafronyl
Etude de la pharmacocinétique du naftidrofuryl et de sa biodisponibilité sous forme de gélule chez l'homme.