The effect of a new antidepressant drug, C-45, and imipramine on some hemodynamic parameters in the dog.
C-45, given to dogs in doses corresponding to 1/30 and 1/10 of LD50 iv, slowed down the cardiac rhythm and depressed systolic, diastolic, and end-diastolic pressures in the left ventricle. A dose of 1/30 of LD50 slightly increased, and a dose of 1/10 of LD50 depressed the indices of contractility of the cardiac muscle. Imipramine produced similar effect but accelerated the cardiac rhythm, and when used in a dose of 1/10 of LD50, it impaired atrioventricular and intraventricular conduction.
D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D004562:Electrocardiography; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D007099:Imipramine / Q000494:pharmacology*; D009200:Myocardial Contraction / Q000187:drug effects; D009287:Naphthyridines / Q000494:pharmacology*
D000929:Antidepressive Agents, Tricyclic; D009287:Naphthyridines; D007099:Imipramine