Effect of prostaglandin A on renin secretion in the dog.
The role of PGA on the release of renin in the anesthetized dog has been studied. The infusion of prostaglandin for 60 minutes at a dose unable to cause pressor modifications (2 microgram/kg/min) was shown to increase the plasma renin activity (PRA); this effect was inhibited by propranolol and strengthened by aminophylline.
D000628:Aminophylline / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004231:Diuresis / Q000187:drug effects; D004285:Dogs; D005260:Female; D007668:Kidney / Q000098:blood supply; D008297:Male; D011433:Propranolol / Q000494:pharmacology; D011454:Prostaglandins A / Q000494:pharmacology*; D012083:Renin / Q000097:blood / Q000378:metabolism*
D011454:Prostaglandins A; D000628:Aminophylline; D011433:Propranolol; D012083:Renin