title: The influence of anti-inflammatory compounds on some effects of BCG in the rat.
abstract: In the rat, intravenous injection of BCG induced an increase in complement activity, oxidative activity towards paraphenylenediamine and serum haptoglobin level. A strong correlation was shown between oxidative activity and haptoglobin level. These increases were inhibited by glucocorticoids (cortisone, dexamethasone, methylprednisolone) but not by two non-steroidal anti-inflammatory drugs (indometacin, phenylbutazone). It is suggested that these BCG effects are related to the release of macrophage constituents and that this is inhibited by glucocorticoids.
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001500:BCG Vaccine / Q000276:immunology / Q000494:pharmacology*; D003165:Complement System Proteins / Q000378:metabolism; D003907:Dexamethasone / Q000494:pharmacology; D006242:Haptoglobins / Q000378:metabolism; D008297:Male; D008775:Methylprednisolone / Q000494:pharmacology; D010084:Oxidation-Reduction; D010655:Phenylenediamines / Q000378:metabolism; D051381:Rats
chemical_list: D000893:Anti-Inflammatory Agents; D001500:BCG Vaccine; D006242:Haptoglobins; D010655:Phenylenediamines; D003907:Dexamethasone; D003165:Complement System Proteins; D008775:Methylprednisolone