Physical mapping of the genes controlling adenovirus paracrystal formation.
The genetic properties and physical mapping of the genes controlling adenovirus-induced paracrystals were examined by means of a new, simplified technique. The induction of paracrystals was virus-strain dependent and blocked by several temperature-sensitive mutations. Using interserotypic recombinants between a paracrystal-producing and a non-producing strain of adenovirus, the principal paracrystal determining factor was mapped between coordinates 30 and 44 on the 100-unit adenovirus genome.
D000260:Adenoviruses, Human / Q000235:genetics* / Q000648:ultrastructure; D002460:Cell Line; D002874:Chromosome Mapping; D003461:Crystallography; D005814:Genes, Viral; D006801:Humans; D007181:Inclusion Bodies, Viral; D009154:Mutation; D011995:Recombination, Genetic; D013696:Temperature