[5H-Pyrimidothiazines. I. Synthesis 6- or 7-carboxyalkyl derivatives of 5H-pyrimido[4,5b][1,4]thiazine].
The synthesis and chemical behaviour of pyrimidothiazine derivatives with a carboxyl group in position 7 [compounds (II) and (III)] or in position 6 [compounds (IV) and (V)] are described. It has been shown that these products, analogous with the isosteric benzothiazines, have the 5H-pyrimidothiazine structure. Compounds (II), (III) and (IV) show immunological activity, inhibiting passive cutaneous anaphyllaxis in the rat.
D000818:Animals; D009682:Magnetic Resonance Spectroscopy; D008722:Methods; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013843:Thiazines / Q000138:chemical synthesis* / Q000494:pharmacology
D011743:Pyrimidines; D013843:Thiazines
Ricerche sulle 5 H-pirimidotiazine. Nota I - Sintesi di derivati 6 o 7 carbossialchil della 5H-pirimido [4,5-b][1,4]tiazina.