title: The in vitro migration inhibition of mononuclear cells in patients with colorectal carcinoma.
abstract: The response of peripheral blood mononuclear cells to PHA and PPD in migration inhibition test has been studied in patients with Duke's B-D colorectal carcinoma. It was found the response of patients cells to both stimulants was increased. This enhanced lymphokine release and/or production was closely connected with the tumor load. The implications of these findings to the regulatory mechanisms of the immune response in cancer patients are briefly discussed.
mesh_terms: D000328:Adult; D000368:Aged; D002464:Cell Migration Inhibition; D003110:Colonic Neoplasms / Q000276:immunology*; D005770:Gastrointestinal Neoplasms / Q000601:surgery; D006801:Humans; D007111:Immunity, Cellular; D008214:Lymphocytes / Q000276:immunology*; D008222:Lymphokines / Q000096:biosynthesis*; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology*; D009362:Neoplasm Metastasis; D010835:Phytohemagglutinins / Q000494:pharmacology; D012004:Rectal Neoplasms / Q000276:immunology*; D014373:Tuberculin
chemical_list: D008222:Lymphokines; D010835:Phytohemagglutinins; D014373:Tuberculin