Lysosomal damage by gliadin and gliadin peptides; an activity not related to coeliac disease.
Rat-liver lysosomes have been used to determine the toxicity of gliadin fractions in relation to coeliac disease. In this study we compared the activity in acid phosphatase release from rat-liver lysosomes by casein, gliadin and by their peptic-tryptic digests. The release of acid phosphatase is not specific for gliadin.
D000135:Acid Phosphatase / Q000378:metabolism*; D000818:Animals; D002364:Caseins / Q000378:metabolism; D002446:Celiac Disease / Q000378:metabolism; D005903:Gliadin / Q000378:metabolism* / Q000633:toxicity; D066298:In Vitro Techniques; D008247:Lysosomes / Q000201:enzymology*; D010940:Plant Proteins / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D002364:Caseins; D010940:Plant Proteins; D005903:Gliadin; D000135:Acid Phosphatase