In vivo toxicity to lymphoid tissue by 2'-deoxycoformycin.
The enzyme adenosine deaminase has an essential role in lymphocyte metabolism. To examine the in vivo effects of inhibition of this enzyme healthy BDF1 mice were injected intraperitoneally with 2'-deoxycoformycin, a stoichiometric tight-binding inhibitor of adenosine deaminase. Of the treated animals, 20% died of overwhelming infection, and histopathological examination of these, and surviving animals sacrificed 10 days following treatment indicated a selective toxicity to lymphoid cells. No toxicity to tissues other than the lymphoid system was observed, which is consistent with the hypothesis that 2'-deoxycoformycin offers a new and selective approach to the treatment of lymphoid malignancies.
D058892:Adenosine Deaminase Inhibitors; D000818:Animals; D001835:Body Weight; D003070:Coformycin / Q000031:analogs & derivatives / Q000633:toxicity*; D008214:Lymphocytes / Q000187:drug effects; D008221:Lymphoid Tissue / Q000187:drug effects* / Q000473:pathology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009700:Nucleoside Deaminases / Q000037:antagonists & inhibitors*; D012263:Ribonucleosides / Q000633:toxicity*; D013154:Spleen / Q000473:pathology
D058892:Adenosine Deaminase Inhibitors; D012263:Ribonucleosides; D003070:Coformycin; D009700:Nucleoside Deaminases