title: [Inhibition of rat liver delta 4-3-ketosteroid-5 alpha-reductase by steroids in vitro].
abstract: The inhibition of the hydrogenation of testerone to 5alpha-dihydrotestosterone in microsomes of female rat liver has been studied by progesterone-, testosterone- and estradiol derivatives. In the pregnane series, progesterone, 17alpha-OH-progesterone and its acetate were the strongest inhibitors. In the estradiol series, 3-hydroxy-compounds with a CH2X-substituent at 17alpha-position were stronger inhibitors than the respective 3-methoxy derivatives. The most potent inhibitor till now is an estradiol derivative with a SeCN group in 16alpha-position.
mesh_terms: D058891:5-alpha Reductase Inhibitors; D000731:Androstanes / Q000494:pharmacology; D000818:Animals; D004958:Estradiol / Q000031:analogs & derivatives / Q000494:pharmacology*; D004962:Estranes / Q000494:pharmacology; D005260:Female; D006908:Hydroxyprogesterones / Q000494:pharmacology; D066298:In Vitro Techniques; D008862:Microsomes, Liver / Q000201:enzymology*; D010088:Oxidoreductases / Q000037:antagonists & inhibitors*; D011282:Pregnenediones / Q000494:pharmacology; D011374:Progesterone / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship; D013739:Testosterone / Q000494:pharmacology*
chemical_list: D058891:5-alpha Reductase Inhibitors; D000731:Androstanes; D004962:Estranes; D006908:Hydroxyprogesterones; D011282:Pregnenediones; D013739:Testosterone; D011374:Progesterone; D004958:Estradiol; D010088:Oxidoreductases
vernacular_title: Hemmung der delta4-3-Ketosteroid-5alpha-reduktase der Rattenleber durch Steroide in vitro.