title: Hemorrhagic tendency in beta-thalassemia major.
abstract: A mild hemorrhagic tendency was observed in a group of beta-thalassemia major patients. This included easy bruising and frequent epistaxis. A consistent platelet anomaly manifested by diminished platelet aggregation to ADP, collagen, ristocetin and epinephrine was found in these patients, and could be responsible in part for the hemorrhagic phenomena.
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology; D000293:Adolescent; D000328:Adult; D001780:Blood Coagulation Tests; D002648:Child; D002675:Child, Preschool; D003094:Collagen / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D006470:Hemorrhage / Q000150:complications*; D006801:Humans; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D012310:Ristocetin / Q000494:pharmacology; D013789:Thalassemia / Q000097:blood* / Q000150:complications
chemical_list: D012310:Ristocetin; D000244:Adenosine Diphosphate; D003094:Collagen; D004837:Epinephrine