Evaluation of the antiasthmatic potential of oxarbazole in guinea pigs.
Oxarbazole, 9-benzoyl-2,3,4,9,-tetrahydro-6-methoxy-1H-carbazole-3-carboxylic acid, inhibited bronchoconstriction induced by a crude SRS-A preparation or by bradykinin in dose-related manner in anesthetized guinea pigs. Oxarbazole was ineffective against bronchoconstriction induced by histamine, carbachol, serotonin, or PGF2alpha. Inhibition of bonchoconstriction induced by the crude SRS-A preparation by oxarbazole was unimpeded by the presence of beta-adrenergic- or cholinergic-blocking agents, but it could be overcome by increased doses of the SRS-A preparation.
D000818:Animals; D001920:Bradykinin / Q000008:administration & dosage; D001986:Bronchial Spasm / Q000139:chemically induced / Q000188:drug therapy*; D001993:Bronchodilator Agents / Q000627:therapeutic use*; D002217:Carbachol / Q000494:pharmacology; D002227:Carbazoles / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D011312:Pressure; D011460:Prostaglandins F / Q000494:pharmacology; D013189:SRS-A / Q000008:administration & dosage; D012701:Serotonin / Q000494:pharmacology; D014132:Trachea / Q000187:drug effects
D001993:Bronchodilator Agents; D002227:Carbazoles; D011460:Prostaglandins F; D013189:SRS-A; D012701:Serotonin; D006632:Histamine; D002217:Carbachol; D001920:Bradykinin