title: Ketamine anesthesia and intraocular pressure.
abstract: We studied the influence of intramuscular ketamine-narcosis on the intraocular pressure of rabbits. Tonography and indirect arterial pressure measurements were performed 5 to 10 minutes after the administration of the agent. The systolic arterial pressure did not change significantly, whereas the intraocular pressure significantly increased. The intraocular pressure increase was 7% on the average with a maximal increase of 20%. In more than half of the cases the arterial and intraocular pressures changed in the opposite directions which speaks for the role of other factors in enhancing these pressure alterations.
mesh_terms: D000768:Anesthesia, General / Q000379:methods*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D007273:Injections, Intramuscular; D007429:Intraocular Pressure / Q000187:drug effects*; D007649:Ketamine / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D011817:Rabbits
chemical_list: D007649:Ketamine