[Significance of the chronic hypoxia and neurohormonal activity in the pathogenesis of ischemic heart disease].
Two kinds of changes in the myocardium were found in the heart beyond the focus of necrosis in people of two age groups (senescent and senile) dying of miocardium infarction. Changes of the first kind (hypoxic) reflect the influence of chronic hypoxia of coronoarogenic origin, are always regional and characterized by fields of optically "empty" muscle fibers with reduced enzymatic activity under sacrolemma and frequently by the presence of non-oriented glycogen granules. Those of the second kind correspond to cardiotoxic effect of high doses of catecholamines and are represented by numerous disseminated micronecroses, focal or diffuse lipid infiltration with myocytes against the background of stromal edema with cell reaction and hemorrhages in it. Cases are considered in which hypoxic and cardiotoxic changes were predominant. Their comparison with the activity of the hypothalamo-hypophysis-adrenal system determined by morphological and histochemical tests (very high and moderately high) revealed some correlation.
D000368:Aged; D002908:Chronic Disease; D003327:Coronary Disease / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D006321:Heart / Q000503:physiopathology; D006728:Hormones / Q000502:physiology*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D000860:Hypoxia / Q000150:complications* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000503:physiopathology; D009206:Myocardium / Q000473:pathology; D010913:Pituitary-Adrenal System / Q000503:physiopathology
D006728:Hormones
Znachenie khronicheskoĭ gipoksii i neĭrogormonal'noĭ aktivnosti v patogeneze ishemicheskoĭ bolezni serdtsa.