title: Larsen's syndrome. Report of three cases in the one family, mother and two offspring.
abstract: Three cases are presented of the very rare Larsen's syndrome, being only the second report in the literature of concomitant involvement of parent (the mother in this instance) and offspring (two children) (see also Haberman et al. 1976). The only therapeutic procedure that is applicable, i.e., surgery, has given only mediocre results over an evolutive period of 8 to 9 years (in case C). We have not been able to demonstrate analytical or histological abnormalities that might provide a diagnostic clue, so that the aetiopathogeny of the disorder remains unknown.
mesh_terms: D000015:Abnormalities, Multiple / Q000000981:diagnostic imaging / Q000235:genetics; D000293:Adolescent; D000328:Adult; D001848:Bone Diseases, Developmental / Q000000981:diagnostic imaging / Q000235:genetics*; D002648:Child; D003025:Clubfoot / Q000235:genetics; D004551:Elbow Joint / Q000002:abnormalities / Q000000981:diagnostic imaging; D005145:Face; D005147:Facial Bones / Q000002:abnormalities; D005260:Female; D006615:Hip / Q000002:abnormalities / Q000000981:diagnostic imaging; D006801:Humans; D007223:Infant; D004204:Joint Dislocations / Q000000981:diagnostic imaging / Q000235:genetics*; D008297:Male; D011859:Radiography; D013577:Syndrome