title: The effect of zinc on alkaline phosphatase activity in rheumatoid synovial tissue.
abstract: To examine the reported beneficial effect of zinc in rheumatoid arthritis, rheumatoid synovial tissue has been maintained in vitro in non-proliferative culture with or without zinc sulphate in the culture medium. Alkaline phosphatase activity was measured by microdensitometry of the cytochemical reaction in cryostat sections; the activity in blood vessels was measured separately from that in the supporting tissue below the synovial surface. Zinc enhanced this activity optimally at concentrations of between 10(-5) and 10(-4) mol/l.
mesh_terms: D000368:Aged; D000469:Alkaline Phosphatase / Q000378:metabolism*; D001172:Arthritis, Rheumatoid / Q000201:enzymology*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D013583:Synovial Membrane / Q000187:drug effects* / Q000201:enzymology; D015032:Zinc / Q000494:pharmacology*
chemical_list: D000469:Alkaline Phosphatase; D015032:Zinc