The influence of intravenous anaesthetic agents on primarily increased intracranial pressure.
In the choice of anaesthetics and techniques the danger of a possible progressive increase of intracranial pressure (ICP) should be considered. Therefore the influence of intravenous anaesthetic agents on mean arterial pressure, ICP, and cerebral perfusion pressure (CPP) in patients with primarily increased ICP was observed under standard conditions for 20-40 minutes. Etomidate, thiopentone, propanidid, and ketamine showed remarkable effects on ICP, even in patients with disturbed cerebro-vascular reactivity. Etomidate and thiopentone cause a fall of ICP by 26%. Because of its stabilizing effects on circulation etomidate does not induce a reduction of CPP, whereas thiopentone will do so because of its depressing effect on blood pressure. Propanidid appears to be a less suitable agent when there is raised ICP, because it induces fluctuations of ICP and blood pressure up to the third minute after injection. According to our results, monoanaesthesia with ketamine cannot be recommended when there is increased ICP because it causes a prolonged increase in ICP, and reduction of blood pressure and CPP.
D000293:Adolescent; D000328:Adult; D000771:Anesthesia, Intravenous; D001794:Blood Pressure / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood; D002560:Cerebrovascular Circulation / Q000187:drug effects; D002648:Child; D004347:Drug Interactions; D005045:Etomidate / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology*; D007427:Intracranial Pressure / Q000187:drug effects*; D007649:Ketamine / Q000494:pharmacology*; D008297:Male; D010197:Pancuronium / Q000494:pharmacology; D011410:Propanidid / Q000494:pharmacology*; D013874:Thiopental / Q000494:pharmacology*; D014655:Vascular Resistance / Q000187:drug effects
D007093:Imidazoles; D002245:Carbon Dioxide; D007649:Ketamine; D011410:Propanidid; D010197:Pancuronium; D013874:Thiopental; D005045:Etomidate