title: [Problems in production, control and utilization of veterinary vaccines in the developing countries].
abstract: For a whole series of reasons, most of which are political, the developing countries are following a policy of national self-sufficiency in veterinary vaccines. They are faced with problems at various levels: (1) at the level of logistic distribution, the developing countries suffer from a shortage of trained personnel, frequently lacking in enthusiasm, an often chronic shortage of funds; poorly equipped premises; poor maintenance of sophisticated but indispensable equipment (e.g. freeze-driers); a lack of facilities for cold storage and of distribution channels; field personnel with limited experience; (2) at the level of production, they must contend with difficulties in obtaining supplies of flasks and glassware; irregular supplies of water and electricity; difficulties in obtaining susceptible animals for quality control. The developing countries have found basically pragmatic solutions to these problems, such as the strict separation of the sites, materials and personnel involved in routine diagnosis and those involved in production; temporary foreign technical assistance, with or without financial aid; the use of simple, unsophisticated techniques, which are known to be reliable, even if somewhat outdated; manufacturing in bulk in multiple-dose bottles; research into the thermostabilisation of vaccine strains and the development of thermoprotective diluents for freeze-drying and reconstitution; the extensive use of combined vaccines; the establishment of production and control standards under the auspices of the WHO/FAO/OIE. In spite of these obstacles, the cost price is particularly low (from 0.20 to 0.35 francs per dose), which compares favourably with that of foreign private industry.
mesh_terms: D000349:Africa; D000818:Animals; D003140:Communicable Disease Control; D003141:Communicable Diseases / Q000662:veterinary*; D003906:Developing Countries; D004467:Economics; D004560:Electricity; D004864:Equipment and Supplies; D014943:Global Health; D008722:Methods; D013672:Technology; D014612:Vaccines / Q000592:standards*; D014881:Water Supply
chemical_list: D014612:Vaccines
vernacular_title: Difficultes de la production, du controle et de l'utilisation des vaccins veterinaires dans les pays en voie de developpement.