Distribution of Thy-1 differentiation alloantigen in the rat nervous system and in a cell line derived from a rat peripheral neurinoma.
The expression of the Thy-l 'differentiation alloantigen' was analyzed in rat tissues of two strains. Cerebrum was shown to express an amount of Thy-l equivalent to the thymus. The cerebellum, brain stem and spinal cord expressed approximately one-half this amount, and the olfactory bulb expressed 10- to 15-fold less. Of the peripheral nervous system tissues examined, only cauda equina expressed substantial amounts of Thy-l, although minor amounts were found on the lumbar roots and trigeminal nerve. Kidney, spleen, liver, salivary gland and testes expressed little or no Thy-l. Several cell lines derived from nervous system tumors were also examined. RN-l, a line established from a rat peripheral neurinoma, expressed Thy-l at levels comparable to thymus.
D000483:Alleles; D000818:Animals; D000951:Antigens, Neoplasm / Q000032:analysis; D002454:Cell Differentiation; D002999:Clone Cells; D007519:Isoantigens / Q000032:analysis* / Q000235:genetics; D009420:Nervous System / Q000276:immunology*; D009442:Neurilemmoma / Q000276:immunology*; D010524:Peripheral Nervous System Neoplasms / Q000276:immunology*; D051381:Rats; D014018:Tissue Distribution
D000951:Antigens, Neoplasm; D007519:Isoantigens