Serum oestriol, oestrone and oestradiol concentrations during oral oestriol succinate treatment in ovariectomized women.
Serum oestriol, oestrone and 17 beta-oestradiol concentrations during oral oestriol succinate treatment were investigated in ovariectomized women. Either a single dose of 8 mg or two doses of 4 mg were given daily. With the second divided dosage the serum oestriol levels remained uniform. The oestriol concentrations were clearly higher than in the beginning or in the middle of the normal menstrual cycle in the fertile woman. With both treatment schemes the ratio E3/(E2 + E1) was clearly higher than before treatment and during the normal menstrual cycle. Oestriol succinate treatment lowered the ratio E1/(E2 + E3), which was rather similar to the one during normal menstrual cycle.
D002369:Castration; D004334:Drug Administration Schedule; D004958:Estradiol / Q000097:blood; D004964:Estriol / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use*; D004967:Estrogens / Q000097:blood* / Q000172:deficiency; D004970:Estrone / Q000097:blood; D005260:Female; D006801:Humans; D008598:Menstruation; D008875:Middle Aged
D004967:Estrogens; D004970:Estrone; D004958:Estradiol; D004964:Estriol