[Metabolism of somatotropin in severe liver diseases. Influence of the therapeutic administration of a liver extract].
Metabolic Clearance Rate (MCR) and half life of 125I Human Growth Hormone (HGH) have been studied in hepatopathic patients. A clear reduction of MCR and a prolongation of HGH half life have been found in all patients examined. After a 30 day therapy with crude liver extract (F.U. VIII ed.) both MCR and HGH half life have shown a tendency towards normalization. These findings are in agreement with the marked improvement of the clinical state of the patients and with the normalization of the laboratory indexes.
D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000188:drug therapy / Q000378:metabolism; D008107:Liver Diseases / Q000188:drug therapy / Q000378:metabolism*; D008110:Liver Extracts / Q000627:therapeutic use*
D008110:Liver Extracts; D013006:Growth Hormone
Il metabolismo dell'ormone somatotropo nelle gravi epatopatie. Influenza della somministrazione terapeutica di un estratto epatico.