Study to confirm the lack of severe cardiac side-effects following treatment with the beta-adrenergic drug fenoterol.
100 patients with premature contractions were treated with the beta-adrenergic agent fenoterol for up to 9 weeks. To rule out a detrimental effect on the myocardium, the creatine kinase isoenzyme MB, which is specific to the myocardium, was determined regularly in addition to electrocardiographic monitoring. No pathological enzyme activity was detected even in long-term tocolytic therapy with the maximum dose.
D000328:Adult; D003402:Creatine Kinase / Q000378:metabolism; D004983:Ethanolamines / Q000009:adverse effects*; D005260:Female; D005280:Fenoterol / Q000009:adverse effects* / Q000627:therapeutic use; D006321:Heart / Q000187:drug effects*; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D009206:Myocardium / Q000201:enzymology; D007752:Obstetric Labor, Premature / Q000517:prevention & control; D011247:Pregnancy
D004983:Ethanolamines; D007527:Isoenzymes; D005280:Fenoterol; D003402:Creatine Kinase