title: Extensive damage to substantia nigra in chronic alcoholics.
abstract: Neuronal depigmentation, necrosis, and increased pigment (melanin) and iron depositions in the perivascular spaces have been observed in the substantia nigra in chronic alcoholics. Eosinophilic nuclear inclusions, the significance of which remains unclear, were noted with an increased frequency within the nuclei of the substantia nigra neurons.
mesh_terms: D000437:Alcoholism / Q000473:pathology*; D001921:Brain / Q000473:pathology; D001927:Brain Diseases / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D004804:Eosinophils; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D009474:Neurons; D010860:Pigments, Biological / Q000378:metabolism; D013378:Substantia Nigra / Q000378:metabolism / Q000473:pathology*
chemical_list: D010860:Pigments, Biological