The mediation of macrophage reaction in inflammation, with special reference to IgG-derived chemotactic factor.
Three different macrophage chemotactic factors were separated from hypersensitivity skin lesions induced by DNP-ascaris extract or PPD. The amount of each factor seemed to be changeable according to the nature of inflammatory stimuli. The chemotactic activity of the factor a was completely absorbed by anti-IgG and anti-light chain antibodies, while that of the factors b and c was not absorbed by the antibodies. The factor a was produced from IgG by neutrophil neutral serine protease resembling elastase but failing to digest elastin-orcein; its chemotactic generation was accompanied by release of dialysable peptide(s) from the IgG molecule, suggesting a minor structural change of the IgG molecule. Production of leucoegresin or lymphocyte chemotactic factor by neutrophil neutral thiol protease from IgG molecule was discussed.
D000818:Animals; D000941:Antigens; D001200:Ascaris / Q000276:immunology; D002634:Chemotaxis, Leukocyte; D004140:Dinitrophenols / Q000276:immunology; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology*; D007249:Inflammation / Q000276:immunology*; D008264:Macrophages / Q000032:analysis*; D009504:Neutrophils / Q000201:enzymology; D010447:Peptide Hydrolases / Q000378:metabolism; D012867:Skin / Q000276:immunology; D014373:Tuberculin / Q000276:immunology
D000941:Antigens; D004140:Dinitrophenols; D007074:Immunoglobulin G; D014373:Tuberculin; D010447:Peptide Hydrolases