The influence of vasopressin on the regional uptake of [3H] orotic acid by rat brain.
After intracarotid injection in the rat followed by decapitation 15 s later, the uptake of the RNA precursor [3H] orotic acid by 18 brain region and by the anterior pituitary was measured. Simultaneously injected lysine-8-vasopressin (1, 10, 100, 1000 and 10000 muU per ml injection solution, respectively) caused a dose-dependent enhancement of tracer uptake by 7 regions, e.g. by the hippocampus. There are indications that especially in this region the blood-brain barrier permeability to the precursor was influenced by the peptide hormone.
D000818:Animals; D001812:Blood-Brain Barrier; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D008236:Lypressin / Q000494:pharmacology*; D008297:Male; D009963:Orotic Acid / Q000378:metabolism*; D010903:Pituitary Gland, Anterior / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D014018:Tissue Distribution
D008236:Lypressin; D009963:Orotic Acid