title: Effect of arginine analogues on a fish pathogen, Aeromonas salmonicida.
abstract: The effects of arginine analogues on a fish pathogen, Aeromonas salmonicida, were investigated. This organism proved to be resistant in various degrees to most arginine analogues tested but was found to be sensitive to arginine hydroxamate. Inhibition of growth by arginine hydroxamate was reversed by the addition of arginine to the bacterial culture. Incorporation of 14C from 14C-amino acids, namely, guanidoarginine, glutamate, asparate, alanine, isoleucine, serine, methyl-methionine, and cystine was affected.
mesh_terms: D000333:Aeromonas / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives* / Q000494:pharmacology; D001426:Bacterial Proteins / Q000096:biosynthesis; D005393:Fish Diseases / Q000382:microbiology*; D006877:Hydroxamic Acids / Q000494:pharmacology; D008055:Lipids / Q000096:biosynthesis; D009696:Nucleic Acids / Q000096:biosynthesis; D012487:Salmonidae
chemical_list: D001426:Bacterial Proteins; D006877:Hydroxamic Acids; D008055:Lipids; D009696:Nucleic Acids; D001120:Arginine