Ultrastructural analysis of haemopoiesis in W/Wv anaemic mice.
This study is an ultrastructural analysis of haemopoiesis in W/Wv anaemic mice in whom the anaemia is caused by a defect in the haemopoietic stem cell. Cellularity of marrow is normal but there is an increase in the proportion of less mature cells suggesting a delay in maturation. In addition, heterochromatin constitutes a higher proportion than normal of the nucleus in most stages of maturation suggesting a defect in DNA activation. The findings suggest that in this strain not only the differentiation of the haemopoietic stem cell but also the maturation of the committed cell is defective.
D000748:Anemia, Macrocytic / Q000473:pathology*; D000818:Animals; D001853:Bone Marrow / Q000648:ultrastructure*; D002452:Cell Count; D004912:Erythrocytes / Q000648:ultrastructure; D006410:Hematopoiesis; D006570:Heterochromatin / Q000648:ultrastructure; D051379:Mice; D008817:Mice, Mutant Strains; D008854:Microscopy, Electron
D006570:Heterochromatin