title: Effect of calcitonin on calcium concentration in serum and liver of rats ligated bile duct.
abstract: The effect of calcitonin (CT) on the serum and liver calcium is examined in rats ligated the bile duct. The subcutaneous administration of CT (80 MCR mU/100 g BW) significantly prevented the increase of serum calcium concentration after a single oral injection of calcium (50 mg/100 g BW) to sham-operated rats. But the ligation of bile duct prevented the hypocalcemic effect of CT. Meanwhile, CT significantly increased the liver calcium content after the calcium injection to sham-operated rats. However, the liver calcium content after CT administration was markedly elevated by the ligation of bile duct in comparison with that of sham-operated rats. The present results suggest that the liver calcium increased by CT administration secretes into the bile.
mesh_terms: D000818:Animals; D001652:Bile Ducts / Q000601:surgery*; D002116:Calcitonin / Q000494:pharmacology*; D002118:Calcium / Q000097:blood / Q000378:metabolism*; D007408:Intestinal Absorption; D008026:Ligation; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051381:Rats
chemical_list: D002116:Calcitonin; D002118:Calcium