Studies on the metabolism and toxicity of dinitrotoluenes--on the absorption and excretion of tritium-labelled 2,4-dinitrotoluene (3H-2, 4-DNT) in the rat.
In order to investigate the detailed absorption and excretion of 2, 4-DNT in the rat, after the single oral administration of 3H2, 4-DNT, the time-course of radioactivity level in blood, liver and digestive organ contents, and of biliary, faecal and urinary excretion were observed. Radioactivity level in blood reaches a peak at 6 hr after the administration and its half-life was about 22 hr. Maximum level of radioactivity in the liver was observed at 6 hr after the administration as well as in the blood. In contrast with the radioactivity levels in blood and liver, amount of radioactivity in small intestine content is markedly decreased for 6 hr after administration. In the biliary excretion, about 10 per cent of the radioactivity administered was excreted in bile within 24 hr. The excretion rate is rising steadily from 6 hr after administration and its peak time was 9-10 hr. In the faecal excretion, the most of the excretion radioactivity was concentrated on 6-9 hr. In the faecal excretion, the most of the excretion radioactivity was concentrated on 6-9 hr faeces as reflected with the biliary excretion pattern. On the other hand, the most of  the urinary excretion radioactivity was concentrated on 0-6 hr urine.
D000042:Absorption; D000284:Administration, Oral; D000818:Animals; D001646:Bile / Q000378:metabolism; D004136:Dinitrobenzenes; D005243:Feces / Q000032:analysis; D007408:Intestinal Absorption; D008297:Male; D009574:Nitro Compounds / Q000008:administration & dosage / Q000378:metabolism; D051381:Rats; D013997:Time Factors; D014018:Tissue Distribution; D014050:Toluene / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism; D014316:Tritium
D004136:Dinitrobenzenes; D009574:Nitro Compounds; D014316:Tritium; D014050:Toluene; C016403:2,4-dinitrotoluene