[Uterine prostaglandins and dysmenorrhea].
In 44 patients a total of 83 determinations in the menstrual blood was performed under standardized conditions. -- The primary PGE 1 and PGF 2 alpha were determined by RIA. Significant differences were found in the PGF 2 alpha concentration in menstrual blood between a group of healthy women and one of patients with dysmenorrhoea. -- In dysmenorrhoea the ration of the PGs investigated is shifted in favour of PGF 2 alpha. Indomethacin can decrease the PGF 2 alpha levels in dysmenorrhoea up to 15 per cent. -- All treated patients reported that their conditions had improved. -- Five out of seven women were completely without any complaints.
D004412:Dysmenorrhea / Q000097:blood* / Q000188:drug therapy; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage; D008598:Menstruation; D011453:Prostaglandins / Q000097:blood*; D011458:Prostaglandins E / Q000097:blood; D011460:Prostaglandins F / Q000097:blood; D011863:Radioimmunoassay
D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; D007213:Indomethacin
Uterine Prostaglandine und Dysmenorrhoe.