title: [Structure-activity relationship in reactivators of acetylcholinesterase inhibited by phosphoric esters. XII. Hydroxyiminomethylalkylpyridine iodomethylate].
abstract: 2-Hydroxyiminomethyl-4-alkylpyridine methiodides were prepared and tested for their in vitro reactivating potency on phosphorylated electric eel cholinesterase. They were also tested as in vivo protecting agents: only one of the compounds, 4-methyl-2-hydroxyiminopyridine, offered a greater protection from DFP than 2-PAM, the others had little to no effect.
mesh_terms: D000110:Acetylcholinesterase / Q000096:biosynthesis*; D000818:Animals; D002800:Cholinesterase Inhibitors / Q000506:poisoning*; D004353:Drug Evaluation, Preclinical; D004524:Eels; D004793:Enzyme Reactivators / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D051379:Mice; D062025:Organophosphate Poisoning; D010091:Oximes / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D011726:Pyridinium Compounds / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D013329:Structure-Activity Relationship
chemical_list: D002800:Cholinesterase Inhibitors; D004793:Enzyme Reactivators; D010091:Oximes; D011726:Pyridinium Compounds; D000110:Acetylcholinesterase
vernacular_title: Relazione struttura-attività nei riattivatori dell'acetilcolinesterasi inibita da esteri fosforici. XII. Idrossiminometilalchilpiridine iodometilate.