title: Cytogenetic observations in infertile men working with insecticidal compounds.
abstract: The negative influence of some insecticides on male fertility has been noted. We report our cytogenetic observations on a group of infertile insecticide workers. Increased chromosomal breakage was a constant finding and the Y chromosome was especially damaged. This may account for impaired spermatogenesis. Furthermore, the involvement of heterochromatic chromosomal variants both in the individual susceptibility to the chemically induced damage and in the reproductive fitness is emphasized.
mesh_terms: D000988:Antispermatogenic Agents; D002869:Chromosome Aberrations / Q000139:chemically induced*; D025063:Chromosome Disorders; D002901:Chromosomes, Human, 13-15; D002902:Chromosomes, Human, 16-18; D002905:Chromosomes, Human, 4-5; D006570:Heterochromatin; D006801:Humans; D006843:Hydrocarbons, Chlorinated; D007248:Infertility, Male / Q000139:chemically induced*; D007306:Insecticides / Q000506:poisoning*; D007621:Karyotyping; D008297:Male; D009943:Organophosphorus Compounds; D012729:Sex Chromosome Aberrations / Q000139:chemically induced*; D013739:Testosterone / Q000032:analysis; D014998:Y Chromosome
chemical_list: D000988:Antispermatogenic Agents; D006570:Heterochromatin; D006843:Hydrocarbons, Chlorinated; D007306:Insecticides; D009943:Organophosphorus Compounds; D013739:Testosterone