Experimental fracture healing: evaluation using radionuclide bone imaging: concise communication.
Radionuclide bone imaging was performed in a rabbit model to observe the course of fracture healing and to establish criteria for distinguishing nonunion and delayed healing from normal healing. Sequential gamma-camera images (with pinhole collimator) were collected and subjected to computer analysis. Five groups were established: a) control--immobilization; b) control--immobilization plus periosteal stripping; c) simple fracture--osteotomy; d) delayed union--osteotomy plus periosteal stripping; and e) nonunion--osteotomy, periosteal stripping and polymethyl methacrylate interposed between fracture fragments. Histographic representation of absolute count rates along rabbit tibias followed a predictable pattern in the simple-fracture and delayed-union groups. They differed only in the time of appearance of phases. The nonunion group demonstrated no recognizable sequential pattern. In this experimental model, serial bone scanning with quantitative data analysis has shown potential for indicating the course of healing in fractures and for serving as a guide to treatment.
D000818:Animals; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D004164:Diphosphonates; D050723:Fractures, Bone / Q000000981:diagnostic imaging* / Q000503:physiopathology; D005599:Fractures, Ununited / Q000000981:diagnostic imaging; D007103:Immobilization; D011817:Rabbits; D011877:Radionuclide Imaging; D013667:Technetium; D013978:Tibial Fractures / Q000000981:diagnostic imaging; D014945:Wound Healing
D004164:Diphosphonates; D013667:Technetium