Stimulation of gastric acid secretion by dimaprit in unanesthetized rats.
In unanesthetized rats, dimaprit and histamine given by intravenous infusion were about equipotent in stimulating gastric acid secretion. The maximal rate of acid secretion in response to dimaprit was significantly greater than to histamine but not significantly different from the response to pentagastrin.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005750:Gastric Juice / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology; D008297:Male; D010418:Pentagastrin / Q000494:pharmacology; D051381:Rats; D011968:Receptors, Histamine / Q000187:drug effects*; D011970:Receptors, Histamine H2 / Q000187:drug effects*; D013890:Thiourea / Q000031:analogs & derivatives* / Q000494:pharmacology
D011968:Receptors, Histamine; D011970:Receptors, Histamine H2; D006632:Histamine; D010418:Pentagastrin; D013890:Thiourea