Absorption of glucose and maltose in congenital glucose-galactose malabsorption.
An intestinal perfusion technique has been used to study absorption of glucose from free glucose and the disacchairde maltose in a patient with congenital glucose-galactose malabsorption. Minimal absorption of glucose occurred from high luminal concentrations of either free glucose (100 mmole/liter) or maltose (50 mmole/liter). Glucose diffused into the intestinal lumen during perfusion of a 2 mmole/liter glucose solution. These observations offer no support for nutritionally important glucose absorption in congenital glucose-galactose malabsorption by either passive diffusion or via a "disaccharidase-related" transport system.
D001692:Biological Transport; D002648:Child; D002675:Child, Preschool; D005690:Galactose / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007408:Intestinal Absorption; D008286:Malabsorption Syndromes / Q000151:congenital* / Q000175:diagnosis / Q000378:metabolism; D008297:Male; D008320:Maltose / Q000378:metabolism*
D008320:Maltose; D005947:Glucose; D005690:Galactose