title: Limitations of a single extra-amniotic injection of prostaglandins in viscous gel to induce midtrimester abortion.
abstract: A dose-response study using PGE2 in a viscous gel has been undertaken for induction of midtrimester abortion. A direct relationship was found between the time to abortion and the dose administered. However, even using PGE2 3.5 mg induced uterine activity was noticed to subside in a significant number of women after approximately 6 h. For routine management it is suggested that PGE2 3.5 mg be injected and followed by repeat doses 6 h later with removal of the injecting catheter on each occasion.
mesh_terms: D000028:Abortion, Induced / Q000379:methods*; D000293:Adolescent; D000328:Adult; D000650:Amnion; D004305:Dose-Response Relationship, Drug; D005260:Female; D005782:Gels; D006801:Humans; D007267:Injections; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011458:Prostaglandins E / Q000008:administration & dosage*
chemical_list: D005782:Gels; D011458:Prostaglandins E