Pharmacokinetics of althesin--comparison with lignocaine.
The plasma concentrations of alphaxalone were measured with a gas chromatographic technique in six patients following a single i.v. injection of Althesin, and in five volunteers following oral administration. A two-compartment open model was used in the pharmacokinetic analysis of the data, and the plasma clearance of alphaxalone was similar to the blood flow through the liver. A comparison with the pharmacokinetics of lignocaine was made.
D000328:Adult; D000530:Alfaxalone Alfadolone Mixture / Q000097:blood*; D000768:Anesthesia, General; D000771:Anesthesia, Intravenous; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000097:blood*; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D011277:Pregnanediones / Q000097:blood*; D013997:Time Factors
D011277:Pregnanediones; D000530:Alfaxalone Alfadolone Mixture; D008012:Lidocaine