title: Effect of BCG cell-wall skeleton immunotherapy on the peripheral blood lymphocytes in patients with lung cancer after radiotherapy.
abstract: The effect of radiotherapy on peripheral blood lymphocytes (PBL) of lung cancer and the effect of BCG cell-wall skeleton (BCG-CWS) on recovery of impaired PBL were examined. A remarkable depression of the absolute number of E- or EAC-rosette cells and of the response of PBL to mitogens were observed immediately after radiotherapy, and these continued for several months. With BCG-CWS immunotherapy, the response of PBL to phytohemagglutinin recovered rapidly, compared with non-vaccinated patients. The response of PBL to pokeweed mitogen seemed to give similar results. These results suggested that BCG-CWS injection to the patient receiving radiotherapy was effective for recovery of T-cell response.
mesh_terms: D000230:Adenocarcinoma / Q000628:therapy*; D001500:BCG Vaccine / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000628:therapy*; D002473:Cell Wall / Q000276:immunology; D005260:Female; D006801:Humans; D007167:Immunotherapy; D008175:Lung Neoplasms / Q000276:immunology / Q000532:radiotherapy / Q000628:therapy*; D008213:Lymphocyte Activation / Q000528:radiation effects; D008297:Male; D008875:Middle Aged; D008934:Mitogens / Q000494:pharmacology; D011878:Radiotherapy / Q000009:adverse effects; D012397:Rosette Formation
chemical_list: D001500:BCG Vaccine; D008934:Mitogens