title: [Unexpected anti-inflammatory activity of rigid structure derivatives of 6-arylpyridazinone antihypertensives. I. Synthesis and activity of 4,4a-dihydro-5H-indeno[1,2c]pyridazin-3-ones].
abstract: The antihypertensive 5-methyl-6-p.cyanophenyl-4,5-dihydro-3(2H)-pyridazinone has been embodied in a rigid framework corresponding to a 4,4a-dihydro-5H-indeno[1,2-c]-3-pyridazinonic structure (II). The resulting 7-cyano derivative (IIc) was found to be devoid of antihypertensive activity. However this compound, as well as other members having structure (II), exhibited antiinflammatory properties.
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis*; D000959:Antihypertensive Agents / Q000138:chemical synthesis*; D008968:Molecular Conformation; D011724:Pyridazines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats
chemical_list: D000893:Anti-Inflammatory Agents; D000959:Antihypertensive Agents; D011724:Pyridazines
vernacular_title: Inattesa attività antiinfiammatoria di strutture rigide derivate da 6-arilpiridazinoni antiipertensivi. Nota I-Sintesi e attività di 4,4a-diidro-5H-indeno[1,2-c]piridazin-3-oni.