[Toxicity and the protective activity of a complex staphylococcal antigen obtained by water extraction].
The toxicity and the protective activity of a complex staphyloccus antigen was studied. Its insignificant toxicity for mice when injected intraperitoneally and protective activity under conditons of experimental infection on mice, rabbits, and guinea pigs were demonstrated. In particular it was shown that the antigen obtained in doses under study protected rabbits from septic staphylococcus infection more than antitoxin and corpuscular vaccine. Under conditons of local experimental infection on mice the complex antigen promoted a more rapid than corpuscular vaccine elimination of the local focus of infection.
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology / Q000302:isolation & purification / Q000633:toxicity*; D004306:Dose-Response Relationship, Immunologic; D006168:Guinea Pigs; D007114:Immunization; D051379:Mice; D011817:Rabbits; D012995:Solubility; D013203:Staphylococcal Infections / Q000276:immunology; D013208:Staphylococcal Toxoid / Q000276:immunology; D013210:Staphylococcus / Q000276:immunology*
D000942:Antigens, Bacterial; D013208:Staphylococcal Toxoid
Toksichnost' i protektivnaia aktivnost' kompleksnogo antigena stafilokokka, poluchennogo metodom vodnoĭ ékstraktsii.