title: [Methods for the appraisal of the safety of antiseptics (author's transl)].
abstract: A procedure is described, topical applications for testing dermal toxicity of antiseptics. The tests for irritancy are made on Guinea pigs: a closed patch test giving us a primary irritation index, and prolonged applications over periods of 90 days giving a superficial aggressivity index. The standard method of testing animals for irritation of the skin is that given in the J.O. April 21, 1971 for cosmetics, changed in order to apply it to antiseptics.
mesh_terms: D000818:Animals; D000891:Anti-Infective Agents, Local / Q000633:toxicity*; D004487:Edema / Q000175:diagnosis; D004890:Erythema / Q000175:diagnosis; D006168:Guinea Pigs; D008722:Methods; D012882:Skin Tests
chemical_list: D000891:Anti-Infective Agents, Local
vernacular_title: Hautentzündungstests zur Untersuchung der Toxizität antiseptischer Lösungen.