[Retinoid-selective ultraviolet phototherapy (SUP) in psoriasis].
27 patients with generalized psoriasis were treated with oral administration of Ro 10-9359 (50--75 mg/d) and daily radiations with a source emitting UVA and UVB light at 292.5--335 nm (so called selective UV-phototherapy, SUP). In 24 patients full remission was seen, partly with few remaining lesions at the predilection sites. The average number of sessions necessary for clearing was 21.6 in 5.3 weeks. The total energy required was 68 J/cm2. Only slight side effects, such as cheilitis and hair loss (4 cases) were seen. The clinical efficacy of this combined retinoid-UV-treatment is comparable to the therapeutic effect of systemic PUVA; however, its practicability seems to be higher, and its application on an out-patient basis better.
D002338:Carotenoids / Q000627:therapeutic use*; D011564:Furocoumarins / Q000627:therapeutic use; D006801:Humans; D010778:Photochemotherapy / Q000379:methods*; D011565:Psoriasis / Q000188:drug therapy / Q000628:therapy*; D014467:Ultraviolet Therapy
D011564:Furocoumarins; D002338:Carotenoids
Retinoid-SUP-Therapie der Psoriasis.