title: Inhibition of GH1 rat pituitary tumor cell adenylyl cyclase activity by somatostatin.
abstract: Somatostatin inhibits basal and chlorpromazine stimulated adenylyl cyclase activity in homogenates of GH1 rat pituitary tumor cells. The Dtryp8-Dcys14 analogue is more potent than tyrosyl somatostatin as an inhibitor of both basal and chlorpromazine-stimulated adenylyl cyclase. Somatostatin had no effect on sodium fluoride or quanylyl-imidodiphosphate-stimulated cyclase in GH1 cell homogenates or on basal, epinephrine or prostaglandin E1 stimulated cyclase activity in sonicated BHK fibroblasts. These results indicate a specific effect of somatostatin to inhibit pituitary adenylyl cyclase activity.
mesh_terms: D000067956:Adenylyl Cyclase Inhibitors; D000818:Animals; D002118:Calcium / Q000494:pharmacology; D002478:Cells, Cultured; D002746:Chlorpromazine / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D005347:Fibroblasts / Q000201:enzymology; D005459:Fluorides / Q000494:pharmacology; D006165:Guanylyl Imidodiphosphate / Q000494:pharmacology; D008274:Magnesium / Q000494:pharmacology; D010911:Pituitary Neoplasms / Q000201:enzymology*; D011458:Prostaglandins E / Q000494:pharmacology; D051381:Rats; D013004:Somatostatin / Q000031:analogs & derivatives / Q000494:pharmacology*
chemical_list: D000067956:Adenylyl Cyclase Inhibitors; D011458:Prostaglandins E; D006165:Guanylyl Imidodiphosphate; D013004:Somatostatin; D008274:Magnesium; D005459:Fluorides; D002118:Calcium; D002746:Chlorpromazine; D004837:Epinephrine