The effect of thyroid hormone on the formation of rat cerebellar Bergmann-glia.
H3-thymidine incorporating cells were demonstrated by autoradiography in the developing cortex. Before the 7-8th days labelled cells were distributed throughout the full width of the internal granular layer. Between days 8 to 14 they were found exclusively in the ganglionic layer and were identified as Bergmann-glia. Thyroid hormone treatment brought about an earlier shift of the label to the ganglionic layer indicating an acceleration of Bergmann-glia formation. Since the acceleration coincided with the known accelerating effect of thyroid hormone on granule cell migration, a causal relationship is assumed between Bergmann-glia formation and granula cell migration.
D000367:Age Factors; D000818:Animals; D001345:Autoradiography; D002455:Cell Division; D002531:Cerebellum / Q000254:growth & development; D006728:Hormones / Q000494:pharmacology; D007553:Isotope Labeling; D008297:Male; D011689:Purkinje Cells / Q000166:cytology / Q000187:drug effects*; D051381:Rats; D014284:Triiodothyronine / Q000494:pharmacology*; D014316:Tritium
D006728:Hormones; D014284:Triiodothyronine; D014316:Tritium