Control of obesity in Avy/a mice by 5alpha-androstan-17-one.
Treating VY/WfL-Avy/a mice with 5 alpha-androston-17-one, a mammalian glucose-6-phosphate dehydrogenase inhibitor, prevented the mice from becoming obese. The weight difference between treated and control Avy/a mice was mainly due to a decreased accumulation of triacylglycerol. The compound did not suppress appetite, had no detectable toxicity and did not affect the lipogenesis rates in the liver and carcass. The weight-controlling effect of 5alpha-androstan-17-one in Avy/a mice was reversible upon withdrawal of treatment.
D015068:17-Ketosteroids / Q000494:pharmacology; D000731:Androstanes / Q000494:pharmacology*; D000818:Animals; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000037:antagonists & inhibitors*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D009765:Obesity / Q000235:genetics / Q000378:metabolism / Q000517:prevention & control*; D014280:Triglycerides / Q000096:biosynthesis
D015068:17-Ketosteroids; D000731:Androstanes; D014280:Triglycerides; C018454:androstan-17-one; D005954:Glucosephosphate Dehydrogenase