Effect of indomethacin on aldosterone secretion in chronic sodium depletion.
Aldosterone secretion rate was determined in sodium repleted and sodium depleted rats 3 to 5 hours hypophysectomy. Sodium depletion was performed by keeping the rats on wheat for six days. This diet resulted in a significant increase in aldosterone secretion rate. Hypersecretion of aldosterone could be observed also after administration of indomethacin, an inhibitor of prostaglandin synthesis.
D000450:Aldosterone / Q000378:metabolism*; D000818:Animals; D003345:Corticosterone / Q000378:metabolism; D004039:Diet, Sodium-Restricted; D007016:Hypophysectomy; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D011188:Potassium / Q000652:urine; D051381:Rats; D012964:Sodium / Q000172:deficiency* / Q000652:urine
D000450:Aldosterone; D012964:Sodium; D011188:Potassium; D003345:Corticosterone; D007213:Indomethacin