Sodium excretion after bilateral adrenalectomy in rats with experimental cirrhosis.
Bilateral adrenalectomy (ADX) or a sham procedure was performed in cirrhotic and control rats. After ADX, controls increased their sodium excretion with respect to the basal values but cirrhotics did not. When sodium-loaded, the ADX cirrhotic rats retained a significant amount of the load. These data do not support a primary role of aldosterone in the impaired sodium handling by cirrhotic rats.
D000315:Adrenalectomy; D000450:Aldosterone / Q000502:physiology; D000818:Animals; D008106:Liver Cirrhosis, Experimental / Q000378:metabolism*; D008297:Male; D009318:Natriuresis; D051381:Rats
D000450:Aldosterone