[Relationship between orally induced immune tolerance and local immune response (author's transl)].
BALB/c mice were immunized by intragastric immunization with sheep red blood cells repeated daily for 4 days. This immunization resulted in the appearance of circulating antibodies which were predominantly of the IgA class. When serum from intragastrically immunized mice was administered intraperitoneally to recipient animals 8 h before parenteral immunization with sheep red blood cells, the subsequent immune response was depressed proportionally to the dose of serum injected. When intragastrically immunized mice were challenged intraperitoneally with sheep red blood cells, the level of the IgM response to the parenteral stimulation was in inverse ratio to the IgA response induced by the oral route. These results suggest that orally induced IgA production is related to orally induced immune tolerance and that systemic hyporesponsiveness is achieved while gut plasma cells are producing specific IgA.
D000284:Administration, Oral; D000818:Animals; D000917:Antibody Formation; D004912:Erythrocytes; D005260:Female; D007106:Immune Sera / Q000008:administration & dosage; D007108:Immune Tolerance; D007070:Immunoglobulin A / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000032:analysis; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D012756:Sheep; D013154:Spleen / Q000276:immunology
D007106:Immune Sera; D007070:Immunoglobulin A; D007075:Immunoglobulin M
Relation entre tolérance immunitaire induite par voie digestive et réponse immune locale.