Oestrogen-induced bone marrow aplasia in a dog.
A case of oestrogen toxicity in the dog is described. The bone marrow was primarily affected with resultant non-regenerative anaemia, leukocytosis followed by leukopaenia, and thrombocytopaenia. Endometritis, toxaemia and disseminate intravascular coagulation were complicating factors. The case terminated fatally intensive therapy.
D000741:Anemia, Aplastic / Q000097:blood / Q000139:chemically induced / Q000662:veterinary*; D000818:Animals; D004054:Diethylstilbestrol / Q000009:adverse effects; D004283:Dog Diseases / Q000139:chemically induced*; D004285:Dogs; D004958:Estradiol / Q000009:adverse effects; D005260:Female; D011247:Pregnancy
D004958:Estradiol; D004054:Diethylstilbestrol