IgE and complement in allergic children.
The following measurements were made using radial immunodiffusion with commercial M-Partigen plaques (Behringwerke, Marburg): Global-IgE in the serum of 29 children (17 atopic asthmas, 3 non atopic asthmas and 9 acute urticarias); C3 and C4 complement fractions in 56 patients (27 atopic asthmas, 11 non atopic asthmas and 18 acute urticarias); C3PA complement fraction in 41 patients (18 atopic asthmas, 9 non atopic asthmas and 14 acute urticarias). High IgE serum levels were observed chiefly in the cases of atopic asthma with polysensitization and in urticarias. The anomaly of the complement system most often found in children was an increase of C4 (23,2% of the cases), not related to the clinical form or duration of the disease. An increase of the C3 fraction (14,6% of the cases) was also observed together with an increase of these two fractions in all the cases where an increase of C3PA was observed. Only in 11,1% of atopic asthmas was a decrease of the serum concentration values of C3 observed.
D000367:Age Factors; D001249:Asthma / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D003176:Complement C3 / Q000032:analysis; D003181:Complement C4 / Q000032:analysis; D003165:Complement System Proteins / Q000032:analysis*; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis*; D008297:Male; D012737:Sex Factors; D014581:Urticaria / Q000276:immunology*
D003176:Complement C3; D003181:Complement C4; D007073:Immunoglobulin E; D003165:Complement System Proteins