The physiologic properties and therapeutic potential of coherin.
Coherin, a peptide isolated from the bovine neurohypophysis, has been shown to be an effective therapeutic agent in post-gastric surgery physiologic obstruction and regional ileitis. Of twenty-four patients with post-gastric surgery physiologic obstruction, coherin relieved symptoms in twenty-three, a 96 per cent efficacy rate. The efficacy of coherin with ileitis was based on the fact that ten of twenty-seven patients treated have required coherin on a continuing basis to stay functional. These patients have requested coherin treatment for an average of five years each, and have each on multiple occasions tried to discontinue coherin treatment with prompt return of symptoms and cessation of symptoms when coherin was reinstituted. All of the ileitis patients had previously failed to respond to standard and usual medical treatment.
D000818:Animals; D003424:Crohn Disease / Q000188:drug therapy; D004285:Dogs; D005500:Follow-Up Studies; D005743:Gastrectomy; D005767:Gastrointestinal Diseases / Q000188:drug therapy*; D005769:Gastrointestinal Motility / Q000187:drug effects; D006801:Humans; D007263:Infusions, Parenteral; D007279:Injections, Subcutaneous; D007415:Intestinal Obstruction / Q000188:drug therapy; D007421:Intestine, Small / Q000187:drug effects; D010455:Peptides / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D010909:Pituitary Hormones, Posterior / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D012008:Recurrence; D013997:Time Factors
D010455:Peptides; D010909:Pituitary Hormones, Posterior