Reaction of human granulopoiesis to high-dose cyclophosphamide therapy.
The reaction pattern of an unperturbed human granulopoiesis to pulses of high-dose chemotherapy (cyclophosphamide 2000 mg/m2 plus vincristine 1.4 mg/m2 or adriamycin 20 mg/m2) was serially studied in 6 patients. The stem cells committed to granulopoiesis (CFU-C) of the bone marrow and the cells of the proliferative granulocytic marrow pool were considerably reduced during the first 8 days. Granulopoietic regeneration was first recognizable by increased proliferative activity of bone marrow CFU-C (3H-thymidine technique). The cytotoxic drug-induced injury to the early compartments of granulopoiesis, and granulocytic regeneration proceed sequentially through the ensuing, increasingly differentiated granulocytic compartments. In the peripheral blood, depletion and repletion of the CFU-C pool precede the corresponding changes of segmented neutrophils by 7 to 9 days; during granulocytic regeneration, peripheral blood CFU-C show a transient greatly overshooting decrease.
D001853:Bone Marrow / Q000187:drug effects; D002452:Cell Count; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000494:pharmacology*; D004317:Doxorubicin / Q000494:pharmacology; D006098:Granulocytes; D006410:Hematopoiesis / Q000187:drug effects*; D006412:Hematopoietic Stem Cells; D006801:Humans; D012038:Regeneration; D013997:Time Factors; D014750:Vincristine / Q000494:pharmacology
D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide