title: Malonaldehyde formation in intact platelets is catalysed by thromboxane synthase.
abstract: Imidazole and compound L8027 (selective inhibitors of thromboxane synthase) produced parallel inhibition of malonaldehyde and thromboxane B2 secretion induced by collagen or thrombin in gel-filtered suspensions of human platelets. Comparing the effects of these inhibitors and aspirin on secretion of granule constituents indicated that platelet degranulation depends mainly on thromboxane production; prostaglandin endoperoxides contributed little.
mesh_terms: D001792:Blood Platelets / Q000201:enzymology*; D006801:Humans; D066298:In Vitro Techniques; D008314:Malonates / Q000096:biosynthesis*; D008315:Malondialdehyde / Q000096:biosynthesis*; D010088:Oxidoreductases / Q000378:metabolism*; D013929:Thromboxane B2 / Q000378:metabolism; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: D008314:Malonates; D008315:Malondialdehyde; D013929:Thromboxane B2; D010088:Oxidoreductases; D013930:Thromboxane-A Synthase