Lymphocyte activation in penicillin allergy: modification of the response to phytohaemagglutinin by benzylpenicilloylated human albumin.
Lymphocytes from twenty-six subjects, allergic or non-allergic to penicillin, were cultured together with phytohaemagglutinin (PHA) and penicillin. The antigen, benzylpenicilloylated human serum albumin (BPO-HSA), induced an enhanced proliferation with PHA in the allergic subjects, but a decreased proliferation with PHA in the non-allergic subjects treated by penicillin (p less than 0.01). The results are interpreted in terms of B- and T-cell regulations in the immune response of man to penicillin.
D000941:Antigens; D002352:Carrier Proteins; D004342:Drug Hypersensitivity / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects; D010406:Penicillins / Q000009:adverse effects / Q000276:immunology*; D010835:Phytohemagglutinins; D012709:Serum Albumin
D000941:Antigens; D002352:Carrier Proteins; D010406:Penicillins; D010835:Phytohemagglutinins; D012709:Serum Albumin