Inhibitory action of pineal extract on LH and FSH.
The influence of melatonin-free pineal extract on luteinizing hormone (LH) and follicle-stimulating hormone (FSH) was studied. Administration of bovine pineal extract in intact rats was found to induce a statistically significant decrease of serum LH and FSH. The pineal extract also inhibited the 24-hour-post-castration rise of serum and pituitary LH and FSH in mature male rats. The stimulating effect of gonadotropin-releasing hormone (GnRH) on pituitary LH and FSH was also inhibited in intact animals. The antigonadotropic activity of melatonin-free pineal extract, melatonin and arginine-vasotocin (AVT) is discussed.
D000818:Animals; D002369:Castration; D005640:Follicle Stimulating Hormone / Q000097:blood*; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D010870:Pineal Gland / Q000502:physiology*; D010902:Pituitary Gland / Q000187:drug effects / Q000502:physiology; D051381:Rats; D014020:Tissue Extracts / Q000494:pharmacology*
D014020:Tissue Extracts; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone