South American plants II: taspine isolation and anti-inflammatory activity.
Croton lechleri L. (Euphorbiaceae), a plant from the Upper Amazon Valley of Peru, yielded the alkaloid taspine. The anti-inflammatory activity of taspine hydrochloride was studied using the carrageenan-induced pedal edema method, the cotton pellet-induced granuloma method, and the adjuvant polyarthritis model.
D000470:Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification*; D001169:Arthritis, Experimental / Q000503:physiopathology; D004487:Edema / Q000503:physiopathology; D006099:Granuloma / Q000503:physiopathology; D007928:Lethal Dose 50; D008297:Male; D008722:Methods; D010568:Peru; D010946:Plants, Medicinal / Q000032:analysis*; D051381:Rats
D000470:Alkaloids; D000893:Anti-Inflammatory Agents; C018394:taspine