Interaction between azapropazone and warfarin.
In vitro studies, using 2 separate techniques, have shown that the anti-inflammatory agent azapropazone caused displacement of warfarin from its plasma albumin binding and it is therfore suggested that such a displacement mechanism may be involved in the reported clinical interaction between these 2 drugs.
D001032:Apazone / Q000097:blood / Q000494:pharmacology*; D001667:Binding, Competitive; D004347:Drug Interactions; D006801:Humans; D011485:Protein Binding; D012709:Serum Albumin / Q000378:metabolism; D014227:Triazines / Q000494:pharmacology*; D014859:Warfarin / Q000097:blood / Q000494:pharmacology*
D012709:Serum Albumin; D014227:Triazines; D014859:Warfarin; D001032:Apazone