title: [Toxicological studies on dichloromethane, a solvent simulating carbon monoxide poisoning (author's transl)].
abstract: Acute oral and inhalation toxicity of dichloromethane was investigated in both male and female Sprague-Dawley rats. Oral LD50 was found to be 1.72 ml/kg for males and 1.06 ml/kg for females. LC50 was found to be 18 100 PPM (1 X 6 hours) for both male and female rats. Acute oral intoxication is characterized by severe vascular changes and depression of the central nervous system accompanied by gastro-intestinal hemorrhagy. A similar CNS depression is also found in acute intoxication by inhalation. The nature of the symptoms as well as the sequence of physiological (hypotension, hypothermia) and biochemical events observed (high COHb level, etc.) indicate that the combined action of dichloromethane and its metabolite, carbon monoxide, are responsible for the development of vascular and CNS disturbances and subsequently the sudden death of the animals.
mesh_terms: D000284:Administration, Oral; D000336:Aerosols; D000818:Animals; D002249:Carbon Monoxide Poisoning / Q000503:physiopathology*; D002263:Carboxyhemoglobin / Q000378:metabolism; D005260:Female; D006843:Hydrocarbons, Chlorinated / Q000633:toxicity*; D007928:Lethal Dose 50; D008297:Male; D008752:Methylene Chloride / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D013997:Time Factors
chemical_list: D000336:Aerosols; D006843:Hydrocarbons, Chlorinated; D008752:Methylene Chloride; D002263:Carboxyhemoglobin
vernacular_title: Etudes toxicologiques sur le dichlorométhane, un solvant simulant l'intoxication par l'oxyde de carbone.