title: [Treatment of stomach ulcer and of Zollinger-Ellison syndrome with cimetidine].
abstract: The treatment of gastric ulcer by the H2-receptor-antagonist Cimetidine results in an ulcer healing rate of 60 to 80% during a 4 to 6 weeks therapy cure. In most studies Cimetidine is superior to placebo or equipotent to a high dose antacid regimen, the latter being accepted to be of beneficial effect on ulcer healing. In the Zollinger-Ellison-syndrome Cimetidine inhibits largely gastric acid hypersecretion and represents for the first time a true alternative to total gastrectomy.
mesh_terms: D000863:Antacids / Q000627:therapeutic use; D002229:Carbenoxolone / Q000627:therapeutic use; D002927:Cimetidine / Q000627:therapeutic use*; D004311:Double-Blind Method; D005750:Gastric Juice / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects; D005755:Gastrins / Q000378:metabolism; D006146:Guanidines / Q000627:therapeutic use*; D006801:Humans; D010919:Placebos; D013276:Stomach Ulcer / Q000188:drug therapy*; D015043:Zollinger-Ellison Syndrome / Q000188:drug therapy*
chemical_list: D000863:Antacids; D005755:Gastrins; D006146:Guanidines; D010919:Placebos; D002927:Cimetidine; D002229:Carbenoxolone
vernacular_title: Die Behandlung des Ulcus ventriculi und des Zollinger-Ellison-Syndroms mit Cimetidin.