title: Oxatomide protects Trichinella spiralis infected mice from lethal anaphylaxis.
abstract: Infection with Trichinella spiralis in mice was accompanied by allergic sensitization as evidenced by anaphylactic death after intravenous injection of the antigen. Pre-treatment of the animals with oxatomide, a new orally active anti-allergic drug, resulted in significant protection of the animals; the lowest effective dose of the compound was 1.25 mg/kg orally. In contrast to cyproheptadine, oxatomide offered little protection against serotonin toxicity in mice. The present data suggest that, in this model of systemic hypersensitivity, the anti-anaphylactic effect of oxatomide can be attributed mainly to inhibition of release of allergic mediators.
mesh_terms: D000707:Anaphylaxis / Q000209:etiology / Q000517:prevention & control*; D000818:Animals; D008297:Male; D051379:Mice; D010879:Piperazines / Q000494:pharmacology*; D012701:Serotonin / Q000633:toxicity; D012702:Serotonin Antagonists; D014235:Trichinellosis / Q000276:immunology* / Q000503:physiopathology
chemical_list: D010879:Piperazines; D012702:Serotonin Antagonists; D012701:Serotonin; C015408:oxatomide