The influence of some thiosemicarbazone derivatives with antiviral activity on immune response in mice.
The aim of the present study was to examine the influence of the thiosemicarbazone-group of compounds with antiviral activity on the humoral and cellular immune response in R III, CBA and Balb/c mice, immunized with sheep erythrocytes or sensitized with oxazolon. The plaque forming cells test, according to Jerne's method and the oxazolon hypersensitivity test were performed. All of the examined compounds, inhibited the humoral immune response, and three of them decreased also the cellular response. The relationship between the antiviral activity and their immuno-suppressive activity has been discussed. Low antiviral activity of compound Hoe 105 could be due to its immunosuppressive action. Moreover, the mechanism of antiviral activity of one of the tested compounds, which displayed strong activity against vaccinia virus, was examined and compared with the activity of methisazone.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D007111:Immunity, Cellular / Q000187:drug effects*; D007074:Immunoglobulin G / Q000096:biosynthesis; D007156:Immunologic Memory / Q000187:drug effects; D007165:Immunosuppression Therapy; D051379:Mice; D008815:Mice, Inbred Strains; D012882:Skin Tests; D013882:Thiosemicarbazones / Q000494:pharmacology*
D007074:Immunoglobulin G; D013882:Thiosemicarbazones