[Influence of duration and depth of ether of brevinarcon narcosis on the cerebral acetylcholine content of rat].
For decapitation of rats in order to determine brain acetylcholine (Ach) content the animals may be anaesthesized slightly by ether no longer than for 2 min, since forebrain Ach content increases quickly up to about 170% throughout the following 3 min. The progress of brain Ach content up to its maximum level is decided both by duration and degree of cns depression: In the moment of most distinctly marked Brevinarcon -narcosis -- evident 2,5 min after i. v. injection (40 mg/kg) -- the forebrain Ach content merely is increased by about 15%, but when anaesthesia is reduced considerably again -- 2,5 min later -- the Ach content only reaches its maximum level.
D000109:Acetylcholine / Q000378:metabolism*; D000768:Anesthesia, General; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D004986:Ether / Q000494:pharmacology*; D005019:Ethyl Ethers / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D051381:Rats; D013858:Thiobarbiturates / Q000494:pharmacology*; D013874:Thiopental / Q000031:analogs & derivatives
D005019:Ethyl Ethers; D013858:Thiobarbiturates; D004986:Ether; C004316:thiobutabarbital; D013874:Thiopental; D000109:Acetylcholine
Einfluss von Dauer und Tiefe einer Ather- oder Brevinarcon -Narkose auf den Hirn-Azetylcholin-Gehalt der Ratte.