Developmental approaches to organ restoration.
This paper discusses the problem of applying the achievements of developmental biology to organ restoration. Experiments on artificially induced transdifferentiation as a prerequisite for organ restoration are reviewed. The advantage of using cells that start differentiation from the dedifferentated state is that they can participate in the construction of new organs. However, cell transdifferentiation is not sufficient for biomedical purposes, since the problem of construction of typically formed organs--namely, the morphogenesis of groups of differentiating cells--remains to be solved. Data, where a partial approach to typical organ restoration has been achieved are analysed. This serves as a tentative step in the application of developmental-biological approaches to the problem of organ restoration.
D000663:Amphibians; D000818:Animals; D002452:Cell Count; D002454:Cell Differentiation; D002478:Cells, Cultured; D004847:Epithelial Cells; D004848:Epithelium / Q000196:embryology; D007908:Lens, Crystalline / Q000166:cytology / Q000196:embryology; D012038:Regeneration; D012160:Retina / Q000166:cytology / Q000196:embryology; D014981:Xenopus