Absence of interaction between X-rays and UV light in inducing ouabain- and thioguanine-resistant mutants in Chinese hamster cells.
Chinese hamster ovary cells were irradiated with X-rays at times from 0 to 17 h before being irradiated with ultraviolet (UV) light. No synergism was observed between the two radiations for the production of mutants resistant to either ouabain or 6-thioguanine. These experiments were designed to test whether X-rays induced an error-prone repair system that would increase the frequency of mutations produced by UV light, but no such system was detected.
D002460:Cell Line; D004247:DNA / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D004351:Drug Resistance; D009154:Mutation; D010042:Ouabain / Q000494:pharmacology; D010641:Phenotype; D013866:Thioguanine / Q000494:pharmacology; D013997:Time Factors; D014466:Ultraviolet Rays; D014965:X-Rays
D010042:Ouabain; D004247:DNA; D013866:Thioguanine