Muscle irritation caused by different products containing oxytetracycline.
Muscle irritation studies were done in rabbits using 9 different commercial products. Eight products had propylene glycol and 1 had polyvinylpyrrolidone as a vehicle. Macroscopical examination 3,6 and 10 days after intramuscular injection indicated that the irritation caused by the 8 products with propylene glycol as a vehicle were very similar. The product with polyvinylpyrrolidone caused much less damage and healing took place more quickly. Saline used as a control caused no tissue damage.
D000818:Animals; D008297:Male; D009132:Muscles / Q000187:drug effects*; D010118:Oxytetracycline / Q000009:adverse effects*; D014677:Pharmaceutical Vehicles; D011205:Povidone / Q000009:adverse effects; D011409:Propylene Glycols / Q000009:adverse effects; D011817:Rabbits
D014677:Pharmaceutical Vehicles; D011409:Propylene Glycols; D011205:Povidone; D010118:Oxytetracycline