[Organ blood flow in graduated, controlled hypotension induced with sodium nitroprusside].
Metabolic acidosis is a characteristic feature of SNP-induced hypotension; this acidosis is of hepatic origin and is not due to underperfusion of the organ but to cyanide-induced anaerobic metabolism. For SNP doses higher than 3 mg/kg body weight, lactate is produced in the myocardium, brain, and skeletal muscles. The observed changes were reversible after hypotension of 20 min duration.
D000818:Animals; D001923:Brain Chemistry; D002302:Cardiac Output / Q000187:drug effects; D004285:Dogs; D005260:Female; D005292:Ferricyanides / Q000494:pharmacology*; D007023:Hypotension, Controlled; D007668:Kidney / Q000032:analysis; D007773:Lactates / Q000032:analysis; D008297:Male; D009132:Muscles / Q000032:analysis; D009206:Myocardium / Q000032:analysis; D009599:Nitroprusside / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000187:drug effects*
D005292:Ferricyanides; D007773:Lactates; D009599:Nitroprusside
Organdurchblutung bei graduierter, kontrollierter Hypotension mittels Natriumnitroprussid (NNP).