Surface topography of immunoglobulin molecules. I. Accessibility of aromatic chromophores of rabbit IgG.
Non-ionic detergent, Tween-20, was used in solvent perturbation studies of accessibility of aromatic amino acid residues in rabbit IgG molecules. It has been found that surface aromatic residues are localized in cervices inaccessible to perturbant molecules larger than ca. 10 A in diameter.
D000818:Animals; D007074:Immunoglobulin G; D011136:Polysorbates / Q000494:pharmacology; D011487:Protein Conformation / Q000187:drug effects; D011817:Rabbits; D013056:Spectrophotometry, Ultraviolet; D014364:Tryptophan; D014443:Tyrosine
D007074:Immunoglobulin G; D011136:Polysorbates; D014443:Tyrosine; D014364:Tryptophan