[Chromatographic fractionation of cholesterol esters in Morgagni's hepatic cirrhosis. Preliminary note].
The behaviour of plasma cholesteryl esters has been investigated in patients with liver cirrhosis (so-called Laennec's cirrhosis). Both absolute and percentage values of esters containing di-, tri- and tetra-unsaturated fatty acids were decreased below the normal range; however, the various esters groups showed unequal decrement rates. These findings may be the result of a low lecithin: cholesterol-acyltransferase (LCAT) activity, due either to depression of the enzyme syntesis in the liver, or to inadequate substrate supply (possibly related with an impaired fatty acid production and lecithin synthesis). A decrease of all ester fractions, or a selective one, could also be induced by the releasing of abnormal hydrolases from damaged liver tissues.
D005591:Chemical Fractionation; D002788:Cholesterol Esters / Q000032:analysis / Q000097:blood*; D002850:Chromatography, Gel; D005227:Fatty Acids / Q000032:analysis; D005260:Female; D006801:Humans; D008099:Liver / Q000201:enzymology; D008104:Liver Cirrhosis, Alcoholic / Q000097:blood* / Q000201:enzymology; D008297:Male; D010713:Phosphatidylcholines / Q000032:analysis / Q000097:blood; D002785:Sterol O-Acyltransferase / Q000378:metabolism
D002788:Cholesterol Esters; D005227:Fatty Acids; D010713:Phosphatidylcholines; D002785:Sterol O-Acyltransferase
Frazionamento cromatografico degli esteri del colesterolo nella cirrosi epatica morgagniana. Nota preliminare.