title: [Biological activity of 1,2-benzylisothiazoles. Relationship between the structure and the auxinlike activity of the 1,2-benzylisothiazol-3-ylacetic acid class].
abstract: The LFER model was used to study quantitatively the interrelations between chemical structure and auxinic activity of some methyl esters of 1,2-benzisothiazol-3-ylacetic acids, using as biological response the cell enlargement induced in etiolated stems of Pisum sativum, var. Alaska. Having demonstrated that activity, expressed as log 1/C, is correlated, by Eq. 8, with factionary charge (-- Qs) calculated for the sulfur atom and with the logarithm of retention time (log t), determined by reverse phase HPLC, the AA. deal with the influences of the latter parameters on the effect registered.
mesh_terms: D007887:Fabaceae / Q000187:drug effects / Q000254:growth & development; D007210:Indoleacetic Acids; D008954:Models, Biological; D010937:Plant Growth Regulators; D010946:Plants, Medicinal; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000494:pharmacology*
chemical_list: D007210:Indoleacetic Acids; D010937:Plant Growth Regulators; D013844:Thiazoles
vernacular_title: Attività biologica di composti 1,2-benzisotiazolici. Relazione fra struttura ed attivià auxinica nella classe degli acidi 1,2-benzisotiazol-3-ilacetici.