title: [Lactacidosis in guanide treatment--a current disease syndrome].
abstract: It is reported on two eldery female diabetics with severe lethal lactacidosis. The clinical picture as well as the laboratory constellation leave no room for doubt about it, though only in one case the estimation of lactate could be performed. A renal insufficiency as involving factor is to be supposed in the two cases. With the help of literature the essential points of view of the clinical picture are discussed and it is referred to its origin also under influence of buformin.
mesh_terms: D000138:Acidosis / Q000139:chemically induced*; D000368:Aged; D001645:Biguanides / Q000009:adverse effects* / Q000627:therapeutic use; D003920:Diabetes Mellitus / Q000188:drug therapy*; D005260:Female; D006801:Humans
chemical_list: D001645:Biguanides
vernacular_title: Laktazidose unter Biguanidbehandlung--ein aktuelles Krankheitsbild.