[Coagulation inhibition caused by selective thrombin blockade with hirudin].
Hirudin causes a rapid inhibition of blood coagulation as shown by in vitro and in vivo experiments in the dog. The substance appears to be a rather specific antithrombin. Its inhibitory action is linearly dose related and therefore easy to control and reproduce. Side effects can be expected to be abolished after further purification of the substance.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D001780:Blood Coagulation Tests; D004285:Dogs; D006629:Hirudins / Q000494:pharmacology*; D006632:Histamine / Q000097:blood; D066298:In Vitro Techniques; D013917:Thrombin / Q000037:antagonists & inhibitors*
D006629:Hirudins; D006632:Histamine; D013917:Thrombin
Gerinnungshemmung durch selektive Thrombinblockade mit Hirudin.