Effect of pulse dose cyclophosphamide on the anamnestic immune response in NZB/W mice.
Mice exhibiting a spontaneous SLE-like lethal autoimmunity (female NZB/W hybrids) were given monthly doses of cyclophosphamide (CPA) 240 mg/kg p.o. starting at four months of age. Antibodies to DNA and sheep red blood cells (SRBC) were measured as well as general well being of the mice. The CPA-treated group demonstrated a marked increased in survival compared to the untreated controls with reduction of anti-DNA antibody levels but only a slight inhibition of the anamnestic response to SRBC immunization.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D004247:DNA / Q000276:immunology; D004334:Drug Administration Schedule; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D007668:Kidney / Q000187:drug effects; D051379:Mice; D008814:Mice, Inbred NZB; D012756:Sheep / Q000276:immunology
D003520:Cyclophosphamide; D004247:DNA