title: Congenital malformations in infants of diabetic mothers.
abstract: In a series of 701 infants born to diabetic women between 1950 and 1974 ,57(8-1 percent) had congential malformations which is a rate three to four timeshigher than in the normal populations of Birmingham.. In 26 cases(3-8 per cent) the malformations were fatal and accounted for 26 per cent of the perinatal mortality in the series.  Central nervous system, cardiovascular and skeletal abnormalities were equally common and there was a high incidence of anencephalus, spina bifida, transposition of the great vessels and sacral dysgenesis...
mesh_terms: D000014:Abnormalities, Drug-Induced; D000328:Adult; D000367:Age Factors; D000757:Anencephaly / Q000453:epidemiology; D001842:Bone and Bones / Q000002:abnormalities; D002648:Child; D000013:Congenital Abnormalities / Q000209:etiology* / Q000401:mortality; D003920:Diabetes Mellitus / Q000145:classification; D005260:Female; D005313:Fetal Death / Q000209:etiology; D006330:Heart Defects, Congenital / Q000453:epidemiology; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects; D007226:Infant Mortality; D007231:Infant, Newborn; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000150:complications*; D016135:Spinal Dysraphism / Q000453:epidemiology
chemical_list: D007004:Hypoglycemic Agents