title: Morphogenesis of the bacterial division septum: a new class of septation-defective mutants.
abstract: A new class of mutants of Salmonella typhimurium (lkyD mutants) are described. The mutants are defective in morphogenesis of the division septum, and are characterized by a failure of the outer membrane to invaginate despite normal ingrowth of the cytoplasmic membrane and murein layers of the growing septum. The cell envelopes of the mutants show a significant decrease in the bound form of murein-lipoprotein and a corresponding increase in the free form of the lipoprotein. This suggests that the morphogenic defect may result from a defect in formation of covalent bonds between the free lipoprotein of the outer membrane and the murein of the nascent septum.
mesh_terms: D000596:Amino Acids / Q000032:analysis; D001426:Bacterial Proteins / Q000032:analysis / Q000378:metabolism; D002455:Cell Division; D008074:Lipoproteins / Q000032:analysis / Q000378:metabolism; D008566:Membranes / Q000378:metabolism / Q000648:ultrastructure; D009154:Mutation; D010641:Phenotype; D012486:Salmonella typhimurium / Q000254:growth & development* / Q000648:ultrastructure; D012995:Solubility
chemical_list: D000596:Amino Acids; D001426:Bacterial Proteins; D008074:Lipoproteins