The reversal of glucose repressed prodigiosin production in Serratia marcescens by the cyclic 3'5'-adenosine monophosphate inhibitor theophylline.
Glucose was found to cause severe repression of prodigiosin production in Serratia marcescens and a dose related partial reversal was demonstrated by theophylline. It is suggested that this reversal is due to the inhibition of cAMP phosphodiesterase and the concomitant increase in cellular cAMP concentration.
D004305:Dose-Response Relationship, Drug; D005947:Glucose / Q000494:pharmacology*; D011353:Prodigiosin / Q000378:metabolism*; D012706:Serratia marcescens / Q000187:drug effects / Q000378:metabolism*; D013806:Theophylline / Q000494:pharmacology*
D013806:Theophylline; D005947:Glucose; D011353:Prodigiosin