Oestrone, oestradiol and testosterone in normal and hypogonadal men following LH-RH or HCG stimulation.
oestrone, oestradiol-17beta and testosterone in serum were measured during a LH-RH infusion test and a Leydig cell function test with HCG in healthy men and in patients with primary or secondary hypogonadism. Following infusion of LH-RH increases of LH (+112%), oestradiol (+62%) and testosterone (+51%) were observed in normal men, while oestrone remained unchanged. Of the patients only those with Klinefelter's syndrome showed a significant increase in testosterone and oestradiol after LH-RH infusion. During the Leydig cell function test oestradiol and testosterone exhibited a largely parallel pattern under normal and pathological conditions as well as in subjects with experimental hypogonadism. Augmentations of plasma oestrone were usually smaller than those for oestradiol.
D006063:Chorionic Gonadotropin / Q000494:pharmacology*; D003117:Color Vision Defects; D004958:Estradiol / Q000097:blood*; D004970:Estrone / Q000097:blood*; D005058:Eunuchism / Q000097:blood*; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology*; D006801:Humans; D007006:Hypogonadism / Q000097:blood* / Q000209:etiology; D008607:Intellectual Disability; D007713:Klinefelter Syndrome / Q000097:blood*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D010911:Pituitary Neoplasms / Q000150:complications; D013577:Syndrome; D013739:Testosterone / Q000097:blood*
D006063:Chorionic Gonadotropin; D004970:Estrone; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D004958:Estradiol; D007986:Luteinizing Hormone