Effects of the intracoronary and intraventricular injections of a commonly available vs. a newly available contrast medium.
Two contrast media (Renografin 76 and Isopaque 370) were used in a double-blind study for coronary angiography and left ventriculography. Fifty-eight patients with presumed coronary artery disease were studied. The effects of the contrast media upon the myocardium and upon ventricular function of patients with and without coronary artery disease were assessed. Pre and post angiography myocardial enzymes were obtained. Cardiac output was determined before and after the angiograms. Hemodynamic and electrocardiographic changes were continuously monitored during the procedure. The study showed that both contrast media produced similar changes; however, the "maximum" decrease in T wave amplitude was more marked in the normal group when Renografin 76 (as compared with Isopaque 370) was injected (p = 0.05) on the right. Renografin 76 injection into the left coronary artery produced a higher median T wave amplitude in lead II relative to Isopaque 370 only in the abnormal group (p = 0.01). The heart rate dropped more severely in the normal patients when the left coronary artery was injected with Renografin 76 than with Isopaque 370 (p = 0.05).
D000790:Angiocardiography; D001219:Aspartate Aminotransferases / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D002986:Clinical Trials as Topic; D003287:Contrast Media / Q000008:administration & dosage / Q000633:toxicity; D003327:Coronary Disease / Q000000981:diagnostic imaging; D003331:Coronary Vessels; D003402:Creatine Kinase / Q000097:blood; D003973:Diatrizoate / Q000008:administration & dosage / Q000633:toxicity; D005069:Evaluation Studies as Topic; D006339:Heart Rate / Q000187:drug effects; D006352:Heart Ventricles; D006801:Humans; D007267:Injections; D007269:Injections, Intra-Arterial; D007463:Iodobenzoates / Q000633:toxicity; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008794:Metrizoic Acid / Q000008:administration & dosage / Q000633:toxicity
D003287:Contrast Media; D007463:Iodobenzoates; D003973:Diatrizoate; D008794:Metrizoic Acid; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D003402:Creatine Kinase