The measurement of muscle mass in children using [15N]creatine.
In eight infants and children who had recovered from protein-energy malnutrition (PEM), muscle mass was estimated by measuring creatine turnover by an isotope dilution technique using [15N]creatine, creatine concentration, and urinary creatinine output. Creatine turnover varied from 1.5 to 2.6% of the muscle creatine pool per day and muscle creatine concentration ranged from 1.7 to 3.9 mug/mug muscle mass was between 15% and 37% of total body weight. The results indicate that daily creatinine output is not a reliable indicator of muscle mass in children who have recently recovered from severe PEM.
D001823:Body Composition / Q000187:drug effects; D002675:Child, Preschool; D003401:Creatine / Q000378:metabolism* / Q000652:urine; D006801:Humans; D007201:Indicator Dilution Techniques; D007223:Infant; D009132:Muscles / Q000033:anatomy & histology* / Q000378:metabolism; D009748:Nutrition Disorders / Q000175:diagnosis*
D003401:Creatine