Studies of the activity of cytosol on the mixed disulfide bond formed by proteins and radio-protector mercaptoethylguanidine.
The cytoplasm of normal and tumorous rat liver cells contains a heat-resistant active compound with reducing ability to break the mixed disulfide bond of albumin-14C-mercaptoethylguanidine. The reducing activity of  cytosol is destroyed by 1000 krd 60Co-gamma-ray doses in diluted solution. In vivo supralethal irradiation of rats does not affect the activity of cytosol prepared from liver cells.
D000418:Albumins / Q000378:metabolism; D000818:Animals; D003600:Cytosol / Q000528:radiation effects; D004220:Disulfides; D005260:Female; D006146:Guanidines / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D051381:Rats
D000418:Albumins; D004220:Disulfides; D006146:Guanidines; D011506:Proteins