title: Criteria in the evaluation of live intranasal influenza virus vaccines.
abstract: Live influenza virus vaccines should meet the following criteria: attenuation, immunogenicity, lack of spread, genetic stability, production in a suitable cell substrate, and  stability during storage. In addition, they should be able to induce a wide antigenic protection. These various aspects will be discussed with reference to the "Alice" strain of live influenza A virus, which possesses all the properties for a good live attenuated virus vaccine.
mesh_terms: D000281:Administration, Intranasal; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D002648:Child; D002986:Clinical Trials as Topic; D006224:Cricetinae; D003429:Cross Reactions; D005069:Evaluation Studies as Topic; D005260:Female; D005289:Ferrets; D005796:Genes; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007109:Immunity; D009980:Influenza A virus / Q000276:immunology; D007252:Influenza Vaccines / Q000008:administration & dosage* / Q000592:standards / Q000627:therapeutic use; D007251:Influenza, Human / Q000517:prevention & control; D008297:Male; D014613:Vaccines, Attenuated / Q000008:administration & dosage
chemical_list: D000914:Antibodies, Viral; D007252:Influenza Vaccines; D014613:Vaccines, Attenuated