[Reactivity and immunogenicity of the Sonne dysentery detergent monovaccine].
The authors elaborated a method of isolation under industrial conditions of Shigella sonnei surface antigens by the treatment of the culture with a detergent (sodium laurylsulfate). The antigens obtained possessed a much lesser toxicity in comparison with the tryptic ones. A method of preparation of a detergent Sonne monovaccine with an increased antigen content (1.3 mg/ml) was described. Experimental series of the preparation were tested on 38 volunteers. A lower reactogenicity of the detergent vaccine (in comparison with the tryptic) and its marked immunological efficacy was demonstrated.
D000942:Antigens, Bacterial / Q000302:isolation & purification; D001428:Bacterial Vaccines / Q000633:toxicity; D003902:Detergents; D004405:Dysentery, Bacillary / Q000517:prevention & control*; D005069:Evaluation Studies as Topic; D006801:Humans; D012764:Shigella sonnei / Q000276:immunology*
D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; D003902:Detergents
Reaktogennost' i immunogennost' dizenteriĭnoĭ detergentnoĭ monovaktsiny Zonne