[Decrease in the immune response in old age and ways of restoring it].
A comparative age study of the immune response in females of CBA mice to the injection of ram erythrocytes has shown that the decreased level of response in old animals depends on the delayed involvement of T- and B-populations of lymphocytes in the process of antibody formation. The intensification of immune response in old animals is possible under the additional antigenic stimulation and introduction of syngenic bone marrow cells from intact mature animals.
D000375:Aging; D000818:Animals; D000917:Antibody Formation; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D005260:Female; D006462:Hemolytic Plaque Technique; D007075:Immunoglobulin M / Q000096:biosynthesis; D051379:Mice; D013154:Spleen / Q000276:immunology; D014184:Transplantation, Homologous
D007075:Immunoglobulin M
Snizhenie immunnogo otveta v starosti i puti ego vosstanovleniia