Effect of immunosuppressive drugs on an in vito correlate of cell-mediated immunity. The migration inhibition test.
The effect of a number of immunosuppressive drugs on the migration-inhibition test was studied. These drugs could be divided into four categories: (1) drugs influencing both the MIF production and MIF effect on macrophages (amethopterin, azathioprine); (2) drugs influencing MIF production (puromycin, actinomycin D); (3) drugs influencing the effect of MIF on macrophages (hydrocortisone); (4) drugs without any influence.
D000818:Animals; D000941:Antigens; D002464:Cell Migration Inhibition; D003864:Depression, Chemical; D005260:Female; D007111:Immunity, Cellular / Q000187:drug effects*; D007114:Immunization; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D066298:In Vitro Techniques; D008263:Macrophage Migration-Inhibitory Factors / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D008297:Male; D011817:Rabbits; D013154:Spleen / Q000276:immunology; D014373:Tuberculin
D000941:Antigens; D007166:Immunosuppressive Agents; D008263:Macrophage Migration-Inhibitory Factors; D014373:Tuberculin