The effect of L-dopa and clomiphene citrate on peripheral plasma levels of luteinizing hormone-releasing factor.
Response of luteinizing hormone-releasing factor (LRF) and gonadotropin levels to orally administered L-dopa and clomiphene citrate were measured in 13 healthy female volunteers. Testing was carried out during the early follicular phase of the menstrual cycle. The results indicated a suggestive but statistically nonsignificant elevation of peripheral plasma LRF following L-dopa administration but no response following clomiphene ingestion. No acute increase in gonadotropin levels was demonstrated in either group. A low but statistically significant positive correlation was found between luteinizing hormone and LRF values determined from the same samples.
D000284:Administration, Oral; D000328:Adult; D002996:Clomiphene / Q000494:pharmacology*; D005260:Female; D005498:Follicular Phase; D007987:Gonadotropin-Releasing Hormone / Q000097:blood*; D006062:Gonadotropins / Q000097:blood*; D006801:Humans; D007980:Levodopa / Q000494:pharmacology*; D007986:Luteinizing Hormone / Q000097:blood; D011863:Radioimmunoassay
D006062:Gonadotropins; D002996:Clomiphene; D007987:Gonadotropin-Releasing Hormone; D007980:Levodopa; D007986:Luteinizing Hormone