[Ribosomal vaccine obtained from Salmonella typhimurium and tested against the challenge of an orally administered virulent microorganism].
Ribosomal preparation obtained from Salmonella typhimurium, used as a vaccine, was able to induce protection of 100% on mice challenged with 5.5 X 10(9) CFU of S. typhimirium administered by oral route. Effective dose at 50% was of 0.1085 mug, expressed as ribonucleic acid (RNA). This vaccine induced an important humoral response as soon as in nine days. The ribosomal preparation used in this work was maintained at 4 degrees C at least for eighty two days. This fact shows an adequate stability of this biological product.
D000284:Administration, Oral; D000818:Animals; D000907:Antibodies, Bacterial; D000917:Antibody Formation; D001428:Bacterial Vaccines / Q000008:administration & dosage; D001688:Biological Products; D005069:Evaluation Studies as Topic; D005260:Female; D007279:Injections, Subcutaneous; D008297:Male; D051379:Mice; D011309:Preservation, Biological; D012335:RNA, Ribosomal / Q000008:administration & dosage*; D012480:Salmonella Infections / Q000517:prevention & control*; D012486:Salmonella typhimurium / Q000276:immunology*
D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D001688:Biological Products; D012335:RNA, Ribosomal
Vacuna ribosomal obtenida de Salmonella typhimurium probada contra el desafío del microorganismo virulento administrado por vía bucal