title: Histological investigation of the etiology of capsule contracture following augmentation mammaplasty.
abstract: Sections obtained from contracted breast capsules were examined by light and electron microscopy. We observed the presence of multiple areas of a particulate foreign material, consistent with the appearance of droplets of dimethylpolysiloxane. An active foreign-body reaction was observed at the interface of the capsule and implant, as well as throughout the tissue subjacent to the deposits of foreign material. Based on these histological observations, we present a theoretical explanation of the etiology of capsular contracture of the breast after augmentation mammaplasty.
mesh_terms: D000328:Adult; D001940:Breast / Q000473:pathology / Q000601:surgery*; D003286:Contracture / Q000209:etiology*; D004129:Dimethylpolysiloxanes; D005260:Female; D005549:Foreign-Body Reaction / Q000473:pathology; D006801:Humans; D019736:Prostheses and Implants / Q000009:adverse effects*; D013518:Surgery, Plastic
chemical_list: D004129:Dimethylpolysiloxanes