[Study of the effect of rifampicin on certain immunological and protective reactions of the body].
The effect of rifampicin on formation of hemagglutinins in mice in response to administration of sheep erythrocytes was studied. The experiments showed that rifampicin administered orally in doses 10-25 times higher than the therapeutic ones did not suppress formation of the antibodies and protective mechanisms of the organism. The antibiotic did not lower the absorbing capacity of the cells by the reticuloendothelial system and the rate of phagocytosis by the leucocytes of the peritoneal exudate in mice. Rifampicin had no effect as well on adaptation of a skin homotransplant in the animals.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000936:Antigen-Antibody Complex; D004247:DNA / Q000378:metabolism; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006388:Hemagglutinins / Q000032:analysis; D007109:Immunity / Q000187:drug effects*; D007962:Leukocytes / Q000187:drug effects; D051379:Mice; D012157:Mononuclear Phagocyte System / Q000187:drug effects; D010587:Phagocytosis / Q000187:drug effects; D012313:RNA / Q000378:metabolism; D012293:Rifampin / Q000276:immunology*; D016038:Skin Transplantation; D014181:Transplantation Immunology / Q000187:drug effects; D014184:Transplantation, Homologous
D000936:Antigen-Antibody Complex; D006388:Hemagglutinins; D012313:RNA; D004247:DNA; D012293:Rifampin
Izuchenie vliianiia rifampitsina na nekotorye immunologicheskie i zashchitnye reaktsii organizma