Effects of cardiac surgery on renal function in children.
In order to determine whether cardiac surgery with cardiopulmonary bypass (CPB) affects renal function in children, glomerular filtration rate (GFR and renal plasma flow (RPF) were determined preoperatively and on the second postoperative day by a single-injection, urineless technique in a randomly selected group of 10 children. The GFR was 126.7 +/- 6.8 ml. per minute per 1.73 sq. M. (mean +/- S.E.M.) before the operation and 127.4 +/- 16.2 on the second postoperative day (p = 0.95). The RPF was 541.7 +/- 80.6 ml. per minute per 1.73 sq. M. preoperatively and 536.0 +/- 82.1 on the second postoperative day (p = 0.8 to 0.9). The results in this group of 10 children indicate that renal function is not markedly altered 2 days after cardiac surgery with CPB and deep hypothermia with circulatory arrest. The study also revealed a falsely decreased creatinine clearance. This was due to an increase in postoperative plasma creatinine values, probably related to an increase in plasma noncreatinine chromogens.
D058186:Acute Kidney Injury / Q000209:etiology; D000293:Adolescent; D001806:Blood Urea Nitrogen; D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000378:metabolism; D005260:Female; D005919:Glomerular Filtration Rate; D006324:Heart Arrest, Induced; D006801:Humans; D007036:Hypothermia, Induced; D007668:Kidney / Q000098:blood supply / Q000502:physiology*; D008297:Male; D011183:Postoperative Complications; D011446:Prospective Studies; D012039:Regional Blood Flow; D012189:Retrospective Studies; D013997:Time Factors
D003404:Creatinine