title: [Diagnosis of left-to-right shunt. Dye dilution curves in patients with left-to-right shunt during physical exertion and after beta-receptor blockade].
abstract: In 79 patients, suffering from central left-to-right shunts, dye-dilution curves were recorded partially using a peripheral venous injection site during reactive hyperaemia. 47 investigations were carried out during ergometer exercise in supine position. 32 patients received injections of 1-2 mg Propranolol or 0,4-0,8 mg Pindolol. During exercise dye-dilution curves showed characteristic alterations, indicating a decrease of the relative shunt-flow, whereas beta-receptor blocking agents increased the relative shunt-flow. Dye-dilution curves written during exercise may be helpful in evaluating the indication for operative closure in patients with small atrial or ventricular septal defects. beta-receptor blocking agents can facilitate diagnosis of left-to-right shunt as a screening test.
mesh_terms: D000293:Adolescent; D000328:Adult; D004374:Ductus Arteriosus, Patent / Q000175:diagnosis; D004395:Dye Dilution Technique; D005260:Female; D006321:Heart / Q000187:drug effects; D006339:Heart Rate; D006343:Heart Septal Defects / Q000175:diagnosis*; D006801:Humans; D005082:Physical Exertion; D010869:Pindolol / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011664:Pulmonary Valve / Q000002:abnormalities; D011667:Pulmonary Veins / Q000002:abnormalities
chemical_list: D011433:Propranolol; D010869:Pindolol
vernacular_title: Zur Diagnose des Links-Rechts-Shunt. Fabrstoffverdünnungskurven bei Patienten mit Links-Rechts-Shunt unter körperlicher Belastung und nach Beta-Rezeptorenblockade