Effect of indomethacin in asthma: evidence against a role for prostaglandins in its pathogenesis.
1. A clinical trial of the effects of indomethacin (200 mg daily) failed to show any objective evidence of improvement in six patients. 2. The same dose failed to inhibit exercise and antigen challenge induced bronchoconstriction, and this was considered to be evidence against the hypothesis that prostaglandins act as chemical mediatros in the pathogenesis of asthma.
D000293:Adolescent; D000328:Adult; D000941:Antigens; D001249:Asthma / Q000188:drug therapy / Q000503:physiopathology*; D002214:Capsules; D002986:Clinical Trials as Topic; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D010366:Peak Expiratory Flow Rate; D005082:Physical Exertion; D011453:Prostaglandins / Q000502:physiology*; D013488:Suppositories
D000941:Antigens; D002214:Capsules; D011453:Prostaglandins; D013488:Suppositories; D007213:Indomethacin