Impairment of granulocyte function in juvenile diabetes.
Granulocyte function of 10 diabetic children has been investigated. At the time of testing the diabetes was in poor control. Five children were retested one week later after adjustment of diet and insulin dose. In contrast to some reports we did not find a phagocytic defect in the ingestion of particles, but the capacity of intracellular killing of Staphylococcus aureus was impaired. Chemotaxis was also reduced whereas the NBT-index and intracellular killing of Candida albicans were normal. Better control of the diabetes led to an improvement of bactericidal killing capacity.
D000293:Adolescent; D001770:Blood Bactericidal Activity; D002176:Candida albicans; D002177:Candidiasis / Q000276:immunology; D002633:Chemotaxis; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D006098:Granulocytes / Q000502:physiology*; D006801:Humans; D007962:Leukocytes / Q000502:physiology*; D010587:Phagocytosis; D013203:Staphylococcal Infections / Q000276:immunology; D013210:Staphylococcus