"Xenogeneic resistance" to rat bone marrow transplantation. III. Maturation age, and abrogation with cyclophosphamide, Corynebacterium parvum and fractionated irradiation.
Lethally irradiated C57 Bl/6 mice and (C57 X A) F1 hybrids fail to accept doses of rat bone marrow cells (5 X 10(6)) which give confluent splenic repopulation in "non-resistant" strains of mice. This phenomenon has been termed "xenogeneic resistance" (XR). XR in (C57 X A) F1 mice can be overridden by a very large inoculum of rat bone marrow (26 X 10(6) cells). XR is not manifest in mice of a resistant strain at ages of 18 days or younger, but is manifest at ages of 22 days and older. XR can be abrogated by agents as varied as: 1) cyclophosphamide, which abrogates XR in a dose dependent manner when given 1 hr prior to lethal irradiation and bone marrow transplantation 2) C. parvum, which abrogates resistance when given 7 days prior to lethal irradiation and bone marrow transplantation, and 3) Fractionated irradiation, which, while capable of abrogating XR, is much less potent than either cyclophosphamide or C. parvum.
D000367:Age Factors; D000818:Animals; D000942:Antigens, Bacterial / Q000008:administration & dosage; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D003520:Cyclophosphamide / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D005260:Female; D006084:Graft Rejection / Q000528:radiation effects; D006410:Hematopoiesis; D006824:Hybridization, Genetic; D007108:Immune Tolerance; D051379:Mice; D008805:Mice, Inbred A; D008810:Mice, Inbred C57BL / Q000276:immunology; D008815:Mice, Inbred Strains / Q000276:immunology*; D011425:Propionibacterium acnes / Q000276:immunology; D011829:Radiation Dosage; D011830:Radiation Effects; D051381:Rats; D013154:Spleen / Q000166:cytology; D014183:Transplantation, Heterologous
D000942:Antigens, Bacterial; D003520:Cyclophosphamide