[The clinical value of histoautoradiographic studies during radiotherapy of cervix carcinoma].
Tissue samples from 35 patients with cervical carcinoma stage I up to stage III were incubated with H-3 -thymidine before and after a test dose of irradiation, as well as several times during treatment until application of the full irradiation dose and the percentage of labelled cells was determined autoradiographically. An important marked decrease in labelling index (subject to individual verification), was found during radiotherapy. The duration of observation was more than two years in the cases of 27 patients. Close correlation was found between the decrease in labelling index and the corresponding clinical course of the disease.
D000328:Adult; D000368:Aged; D001345:Autoradiography; D001706:Biopsy; D002277:Carcinoma / Q000473:pathology / Q000532:radiotherapy; D004273:DNA, Neoplasm / Q000096:biosynthesis; D005260:Female; D006652:Histological Techniques; D006801:Humans; D066298:In Vitro Techniques; D008875:Middle Aged; D013936:Thymidine / Q000378:metabolism; D014316:Tritium; D002583:Uterine Cervical Neoplasms / Q000378:metabolism / Q000473:pathology / Q000532:radiotherapy*
D004273:DNA, Neoplasm; D014316:Tritium; D013936:Thymidine
Der klinische Wert histoautoradiographischer Untersuchungen während der Strahlentherapie des Zervixkarzinomas