Features of the immune response to DNA in mice II. Participation of B and T cells.
The respective roles of thymus-derived and bone marrow-derived lymphocytes in the immune response to DNA was investigated in mice reconstituted with various cell populations using cell transfers. A helper effect of thymus-derived cells in the immune response to DNA was suggested by experiments performed in athymic nude BALB/c mice. Reconstitution experiments performed in low responder DBA/mice indicated that the immune response to DNA can be increased after transfer of bone marrow cells from high responder NZB mice, even in the presence of thymocytes from DBA/2 mice. In NZB X NZW mice, a major role of bone marrow cells, with a possible modulation by thymus-derived cells during aging, was observed in the spontaneous development of anti-DNA antibodies.
D000818:Animals; D000906:Antibodies / Q000032:analysis; D000917:Antibody Formation; D000921:Antibody-Producing Cells; D001402:B-Lymphocytes / Q000276:immunology*; D001853:Bone Marrow / Q000276:immunology; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D004247:DNA / Q000276:immunology*; D005260:Female; D007114:Immunization; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008819:Mice, Nude; D012710:Serum Albumin, Bovine; D013601:T-Lymphocytes / Q000276:immunology*; D014184:Transplantation, Homologous
D000906:Antibodies; D012710:Serum Albumin, Bovine; D004247:DNA