Ascorbic acid inhibits covalent binding of enzymatically generated 2-acetyl-aminofluororene-N-sulfate to DNA under conditions in which it increases mutagenesis in salmonella TA-1538.
D015073:2-Acetylaminofluorene / Q000378:metabolism* / Q000494:pharmacology; D001205:Ascorbic Acid / Q000494:pharmacology*; D002850:Chromatography, Gel; D004247:DNA / Q000378:metabolism*; D005449:Fluorenes / Q000378:metabolism*; D009154:Mutation / Q000187:drug effects*; D012475:Salmonella / Q000187:drug effects / Q000235:genetics; D013431:Sulfates / Q000378:metabolism
D005449:Fluorenes; D013431:Sulfates; D004247:DNA; D015073:2-Acetylaminofluorene; D001205:Ascorbic Acid