Mechanisms of protective immunity in experimental cutaneous leishmaniasis of the guinea-pig. II. Selective destruction of different Leishmania species in activated guinea-pig and mouse macrophages.
Macrophages activation as the effector mechanism in destroying L. enriettii in the guinea-pig, and L. tropica in the mouse, was tested in vitro. Activated guinea-pig macrophages, with enhanced anti-Listeria capacity had no effect on the survival of intracellular L. enriettii, irrespective of the antigen used. Activated mouse macrophages, on the other hand, destroyed ingested L. enriettii within 24-48 hr but had no effect on L. tropica during the same time period. It is suggested that the pathogenicity of a Leishmania parasite in a given host depends on the ability of the parasite to survive in the host's activated macrophages. The possible mechanisms by which L. enriettii evades destruction in activated guinea-pig macrophages are discussed.
D000818:Animals; D000941:Antigens; D001500:BCG Vaccine; D002470:Cell Survival; D006168:Guinea Pigs; D007111:Immunity, Cellular; D066298:In Vitro Techniques; D007891:Leishmania / Q000254:growth & development / Q000276:immunology / Q000302:isolation & purification; D007896:Leishmaniasis / Q000276:immunology*; D008087:Listeria / Q000276:immunology; D008213:Lymphocyte Activation; D008264:Macrophages / Q000276:immunology* / Q000469:parasitology; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009163:Mycobacterium bovis; D010587:Phagocytosis; D014122:Toxoplasma
D000941:Antigens; D001500:BCG Vaccine