title: Manipulation of allograft immunogenicity by pretreatment of cadaver donors.
abstract: The experimental basis forming the rationale for the reduction of allograft immunogenicity prior to transplantation is described. This is based on the hypothesis that ""passenger leucocytes'' are a major immunogenic stimulus in rejection. Donor pretreatment with high doses of methylprednisolone and cyclophosphamide can be used clinically for cadaver donor pretreatment and when combined with an adequate post-transplant chemical immunosuppressive regimen results in an important in improvement in overall results as seen in a series followed for 5 1/2 years.
mesh_terms: D000818:Animals; D002102:Cadaver; D006084:Graft Rejection / Q000187:drug effects; D006650:Histocompatibility Testing; D006801:Humans; D007111:Immunity, Cellular; D007165:Immunosuppression Therapy / Q000379:methods*; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D007668:Kidney / Q000276:immunology; D016030:Kidney Transplantation; D008214:Lymphocytes / Q000276:immunology; D011182:Postoperative Care; D011292:Premedication; D011300:Preoperative Care; D051381:Rats; D014019:Tissue Donors; D014022:Tissue Survival / Q000187:drug effects; D014181:Transplantation Immunology; D014184:Transplantation, Homologous
chemical_list: D007166:Immunosuppressive Agents