[Problems posed by the therapeutic combination of phenobarbital and sodium dipropylacetate. Apropos of a case].
The authors report on the observation of an epileptic woman who showed the clinical and electro-encephalographic symptoms of an overdose of barbiturates when undergoing treatment associating Depakine and Gardenal. Resumption of the treatment results in identical symptoms. The potentialisation of this association and the mechanism by which it acts are as yet unknown.
D000328:Adult; D003975:Diazepam / Q000627:therapeutic use; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D004569:Electroencephalography; D004827:Epilepsy / Q000188:drug therapy / Q000503:physiopathology; D005260:Female; D006801:Humans; D010634:Phenobarbital / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D014631:Valerates / Q000009:adverse effects*; D014635:Valproic Acid / Q000009:adverse effects* / Q000627:therapeutic use
D014631:Valerates; D014635:Valproic Acid; D003975:Diazepam; D010634:Phenobarbital
Problèmes posés par l'association thérapeutique phénobarbital-dipropylacétate de sodium. A propos d'un cas