[Chemotherapeutically active nitro compounds. 2nd communication: Nitrodiphenyl sulfones (author's transl)].
A number of new 4-nitro-4'-amino-diphenyl sulfones and related compounds were prepared and investigated as to their therapeutic activity. They showed a good systemic activity against tubercle bacilli (M. bovis, NMRI mouse) and plasmodia (P. berghei, NMRI mouse). The test results reveal that the 4-nitro-4'-amino-diphenyl sulfones possess a spectrum of activity similar to that of diamino-diphenyl sulfone (DDS). It is assumed that 4-nitro-4'-amino-diphenyl sulfones in vivo are converted into DDS derivatives by reduction. The advantages of the new compounds, however, were too insignificant as compared to DDS to justify further extensive trials.
D000818:Animals; D003622:Dapsone / Q000031:analogs & derivatives; D008288:Malaria / Q000188:drug therapy; D051379:Mice; D008815:Mice, Inbred Strains; D009164:Mycobacterium Infections / Q000188:drug therapy; D009163:Mycobacterium bovis; D009578:Nitrobenzenes / Q000138:chemical synthesis* / Q000627:therapeutic use; D010962:Plasmodium berghei; D013450:Sulfones / Q000138:chemical synthesis* / Q000627:therapeutic use
D009578:Nitrobenzenes; D013450:Sulfones; D003622:Dapsone
Chemotherapeutisch wirksame Nitroverbindungen. 2. Mitteilung: Nitrodiphenylsulfone