Metabolism of branched medium chain length fatty acid. II--beta-oxidation of sodium dipropylacetate in rats.
Catabolic intermediates of sodium dipropylacetate, an anticonvulsant drug, in the urine extracts of the drug-treated rats were examined by the aid of gas chromatography mass spectrometry. Eleven drug-specific peaks were estimated as unmetabolized sodium dipropylacetate, succinic acid, 2-n-propyl-3-hydroxypentanoic acid, 2-n-propyl-4-hydroxypentanoic acid, 2-n-propyl-3-oxopentanoic acid, 2-n-propyl-5-hydroxypentanoic acid, adipic acid, 2-n-propylglutaric acid, dipropylacetic acid glucuronide, propionic acid and 3-heptanone. Administration of sodium dipropylacetate with isoleucine to rats resulted in the disappearance of 2-n-propyl-3-oxopentanoic acid and a considerable decrease in 2-n-propyl-3-hydroxypentanoic acid. These data indicated that beta-oxidation was involved in the metabolism of sodium dipropylacetate as well as glucuronide conjugation and omega oxidation.
D000818:Animals; D002245:Carbon Dioxide / Q000378:metabolism; D002849:Chromatography, Gas; D002853:Chromatography, Liquid; D005227:Fatty Acids / Q000378:metabolism*; D005232:Fatty Acids, Volatile / Q000378:metabolism; D007532:Isoleucine / Q000494:pharmacology; D008297:Male; D013058:Mass Spectrometry; D010084:Oxidation-Reduction; D011422:Propionates / Q000378:metabolism; D051381:Rats; D013386:Succinates / Q000378:metabolism; D014297:Trimethylsilyl Compounds; D014631:Valerates / Q000378:metabolism*; D014635:Valproic Acid / Q000378:metabolism* / Q000652:urine
D005227:Fatty Acids; D005232:Fatty Acids, Volatile; D011422:Propionates; D013386:Succinates; D014297:Trimethylsilyl Compounds; D014631:Valerates; D007532:Isoleucine; D002245:Carbon Dioxide; D014635:Valproic Acid