Anorectic and motor activity effects of some 1-benzylcycloalkylamines in the rat.
1. A series of 1-benzylcycloalkylamines with cycloalkyl rings of five, six or seven carbons and with various benzyl ring substituents (3-Cl, 4-Cl, 4-F, 3-CF3) was prepared and tested for anorectic and motor activity effects in rats. 2. Two potent, non-stimulant, anorectics were found: 1-(3-chlorobenzyl)-cycloheptylamine, and its N-methyl analogue. The activity of these compounds resembled that of chlorphentermine.
D000588:Amines / Q000494:pharmacology*; D000818:Animals; D001067:Appetite Depressants; D001596:Benzylamines / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D007928:Lethal Dose 50; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats
D000588:Amines; D001067:Appetite Depressants; D001596:Benzylamines