title: The classic. Streptomycin in tuberculous bone and joint lesions with mixed infection and sinuses.
abstract: At the present time, streptomycin represents a tremendous advance in the treatment of patients with these lesions. Streptomycin undoubtedly will be improved upon and superseded by some other agent in the future, giving us better control of this disease and possibly enabling us to eradicate it. In closed lesions streptomycin, in dosages of 90 grams in a period of 90 days, has failed to arrest the tuberculous process permanently. Failure of treatment with streptomycin suggests strongly the presence of a sequestrum, a thick-walled abscess, or inadequate surgery. Healing seems to be related to the duration of administration of streptomycin and not to the total dosage. In patients having sinuses, streptomycin should be continued after healing for a period at least half as long as the healing period itself. Surgical ankylosis, or resection of non-weight-bearing joints, is apparently as necessary now as it ever has been, but is much safer and more effective. Indeed, at times surgical attack is made possible only by the use of streptomycin.
mesh_terms: D002648:Child; D005260:Female; D049673:History, 20th Century; D006801:Humans; D008297:Male; D013307:Streptomycin / Q000008:administration & dosage / Q000266:history* / Q000627:therapeutic use; D014394:Tuberculosis, Osteoarticular / Q000188:drug therapy / Q000266:history*; D014399:Tuberculosis, Spinal / Q000188:drug therapy / Q000266:history; D014481:United States
chemical_list: D013307:Streptomycin