Mutagenicities of nitrofuran derivatives on a bacterial tester strain with an R factor plasmid.
Many nitrofuran derivatives are known to be mutagenic on Escherichia coli WP2 but not on Salmonella typhimurium TA1535, TA1536, TA1537 or TA1538. Ames and coworkers recently obtained a new tester strain of S. typhimurium, TA100, by putting an R factor plasmid, pKM101, into TA1535. We found that all mutagenic nitrofuran derivatives previously found to be mutagenic on E. coli WP2 were mutagenic on this new strain (TA100).
D004352:Drug Resistance, Microbial; D005111:Extrachromosomal Inheritance / Q000187:drug effects*; D009153:Mutagens; D009581:Nitrofurans / Q000633:toxicity*; D010957:Plasmids / Q000187:drug effects*; D011815:R Factors / Q000187:drug effects; D012486:Salmonella typhimurium / Q000187:drug effects*
D009153:Mutagens; D009581:Nitrofurans