title: Psychiatric problems in intensive care. Five patients with acute confusional states and depression.
abstract: Five case histories are presented of patients with multiple trauma or severe infection, who developed psychiatric symptoms after an initially favourable response to intensive therapy. Alterations in the level of consciousness and behavioural pattern were observed, associated with the presence of acute depression, possibly primarily endogenous in origin. Following intravenous Clomipramine administration, considerable improvement was noted in all five patients, regarding both the depressive state and the clouding of consciousness. The importance of recognising psychiatric disorder in severly ill patients in an intensive therapy environment is stressed.
mesh_terms: D000328:Adult; D000368:Aged; D002997:Clomipramine / Q000627:therapeutic use; D003072:Cognition Disorders / Q000209:etiology*; D003221:Confusion / Q000188:drug therapy / Q000209:etiology*; D003244:Consciousness Disorders / Q000209:etiology; D003422:Critical Care; D003863:Depression / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007239:Infections / Q000628:therapy; D007263:Infusions, Parenteral / Q000009:adverse effects; D007442:Intubation, Intratracheal / Q000009:adverse effects; D008297:Male; D001523:Mental Disorders / Q000209:etiology; D008875:Middle Aged; D011175:Positive-Pressure Respiration / Q000009:adverse effects; D011596:Psychomotor Disorders / Q000209:etiology; D012131:Respiratory Insufficiency / Q000628:therapy; D014947:Wounds and Injuries / Q000628:therapy
chemical_list: D002997:Clomipramine