Biological studies on a strain of Escherichia coli B resistant to chlorpromazine.
A strain of Escherichia coli B resistant to chlorpromazine was developed from the sensitive strain. Cells of the resistant strain were different from those of the sensitive strain. Thus, the permeability of the resistant cells (measured by the uptake of 14C-glutamic acid) was not interfered with by Cpz. Moreover, the resistant cells were able to cause detoxification or partial detoxification of the drug.
D002746:Chlorpromazine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D005971:Glutamates / Q000378:metabolism; D013053:Spectrophotometry
D005971:Glutamates; D002746:Chlorpromazine