The kinetics of beta-granule formation: a morphometric study.
The rate of formation of beta-granules in mouse islet cells has been studied by morphometry using experimental conditions in which insulin secretion is known to be blocked. The number of beta-granules in a cell is increased by 120%, 45 minutes after a continued glucose stimulus of 16.7 mM. The implications of the results are discussed with respect to the construction of kinetic models for the secretion of insulin by exocytosis.
D000818:Animals; D001699:Biometry / Q000379:methods; D003594:Cytoplasmic Granules; D004837:Epinephrine / Q000494:pharmacology; D005089:Exocytosis; D005947:Glucose / Q000494:pharmacology; D007328:Insulin / Q000096:biosynthesis*; D007515:Islets of Langerhans / Q000378:metabolism* / Q000648:ultrastructure; D007700:Kinetics; D051379:Mice; D008954:Models, Biological
D007328:Insulin; D005947:Glucose; D004837:Epinephrine