A study of blood coagulation parameters.
The object of this study was to determine the presence or absence of abnormalities in a variety of blood coagulation parameters in women on contraceptive medication. A prospective double-blind study involving a control group with a total study enrollment of 211 women during a 29 month period was established. Although research has not proved that changes in coagulation parameters will cause abnormal clotting in normal patients, a pattern appears to be developing involving antithrombin III determinations. Corresponding patterns do not appear to be developing in the other blood coagulation parameters.
D000293:Adolescent; D000328:Adult; D000991:Antithrombins / Q000097:blood; D001777:Blood Coagulation / Q000187:drug effects*; D001778:Blood Coagulation Disorders / Q000139:chemically induced; D001779:Blood Coagulation Factors / Q000032:analysis; D002986:Clinical Trials as Topic; D003276:Contraceptives, Oral / Q000009:adverse effects*; D003280:Contraceptives, Oral, Synthetic / Q000009:adverse effects*; D004338:Drug Combinations; D005040:Ethynodiol Diacetate / Q000009:adverse effects; D005260:Female; D006801:Humans; D008598:Menstruation; D008656:Mestranol / Q000009:adverse effects; D011446:Prospective Studies
D000991:Antithrombins; D001779:Blood Coagulation Factors; D003276:Contraceptives, Oral; D003280:Contraceptives, Oral, Synthetic; D004338:Drug Combinations; D005040:Ethynodiol Diacetate; D008656:Mestranol