Computer subtraction in regional cerebral blood-volume measurements using the EMI-Scanner.
A computerized subtraction technique has been described to measure regional cerebral blood volume (rCBV) using the EMI-Scanner in a group of 13 patients. Sodium iothalamte was injected intravenously (1-75 ml./kg) to increase the absorption of X rays in the cerebral circulation. Significant regional differences in CBV were shown, values in the frontal and temporal regions being lower than the mean hemisphere value (4-9 +/- 0-7) and higher in the occipital region. The left hemisphere showed a significantly higher CBV when compared with the right. Measurements of CBV in the cortex showed no regional variation, but the mean cortical value of 6-0 +/- 1-8 was significantly higher than the hemisphere mean.
D001810:Blood Volume; D001811:Blood Volume Determination / Q000379:methods; D001921:Brain / Q000098:blood supply*; D001932:Brain Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging; D002561:Cerebrovascular Disorders / Q000000981:diagnostic imaging / Q000503:physiopathology; D003201:Computers; D006801:Humans; D009362:Neoplasm Metastasis; D012039:Regional Blood Flow; D013382:Subtraction Technique / Q000379:methods*; D014056:Tomography, X-Ray / Q000379:methods*