The effect of food and clopamide on the absorption of pindolol in man.
Plasma levels and urinary excretion of pindolol were measured in each of two groups of eleven subjects in order to compare the absorption of the drug when administered alone in the fasting state, and either with food or Binaldix. The data were analyzed according to a one-compartment model with first order absorption. No significant differences in absorption of pindolol were obtained in each study. Food appeared to increase the speed of absorption of pindolol leading to a slightly earlier and higher maximum plasma concentration, but this observation appears to be of no clinical relevance.
D000328:Adult; D002986:Clinical Trials as Topic; D003005:Clopamide / Q000494:pharmacology*; D004435:Eating; D005215:Fasting; D005260:Female; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D007700:Kinetics; D008297:Male; D008954:Models, Biological; D010869:Pindolol / Q000378:metabolism*
D003005:Clopamide; D010869:Pindolol