A single-blind comparative clinical trial of lymecycline and amoxycillin in the treatment of acute bronchitis in general practice.
A single-blind comparison of lymecycline and amoxycillin was performed by three general practitioners in the treatment of acute bronchitis. A total of 132 patients were treated for seven days with lymecycline (204 mg) two capsules twice daily or amoxycillin 250 mg three times daily. Symptoms and signs assessed were cough, dyspnoea, sputum volume, purulence of sputum and temperature. Both drugs brought about a statistically significant improvement. For all parameters the improvements seen with lymecycline were superior to those seen with amoxycillin although in no case did any of these reach statistical significance. However, in the case of purulent sputum those patients receiving lymecycline showed improvement which reached borderline significance (0-05 less than p less than 0-1) as compared with amoxycillin. Side-effects in the case of both drugs were negligible.
D000208:Acute Disease; D000658:Amoxicillin / Q000627:therapeutic use*; D000667:Ampicillin / Q000031:analogs & derivatives*; D001991:Bronchitis / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008194:Lymecycline / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D013754:Tetracyclines / Q000627:therapeutic use*
D013754:Tetracyclines; D000667:Ampicillin; D008194:Lymecycline; D000658:Amoxicillin