[Pharmacokinetic characteristics and the chemotherapeutic effectiveness of a 2% ditetracycline-erythromycin eye ointment].
The study of the antibacterial activity of ditetracycline combination with erythromycin (ratio 1 : 1) showed that the effect of the antibiotics increased with respect to most of Staphylococcus and Coli bacteria. The chemotherapeutic effect of the ointment in treatment of experimental staphylococcal conjunctivitis of rabbits was also studied. The clinical signs of the disease disappeared earlier than in the experiments with the use of ditetracycline and erythromycin ointments alone. The experiments with the rabbits revealed a prolonged effect of the ointment: ditetracycline and erythromycin in therapeutic concentrations were detected in the conjunctiva and cornea after a single application for 24--48 and 8 hours respectively.
D000818:Animals; D001082:Aqueous Humor / Q000187:drug effects; D001702:Biopharmaceutics; D003228:Conjunctiva / Q000187:drug effects; D003231:Conjunctivitis / Q000188:drug therapy; D003315:Cornea / Q000187:drug effects; D003692:Delayed-Action Preparations; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D004917:Erythromycin / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D005123:Eye; D007700:Kinetics; D008826:Microbial Sensitivity Tests; D009824:Ointments; D011817:Rabbits; D013203:Staphylococcal Infections / Q000188:drug therapy; D013210:Staphylococcus / Q000187:drug effects; D013754:Tetracyclines / Q000494:pharmacology*; D013997:Time Factors
D003692:Delayed-Action Preparations; D004338:Drug Combinations; D009824:Ointments; D013754:Tetracyclines; D004917:Erythromycin
Osobennosti farmakokinetiki i khimioterapevticheskaia éffektivnost' 2% ditetratsiklin-éritromitsinovoĭ glaznoĭ mazi