The role of macrophages in the adjuvant effect on antibody production of Corynebacterium parvum.
Spleen cells from mice pre-treated with C. parvum gave an enhanced in vitro antibody response to SRBC, but not to DNP-POL. This enhancing activity was associated with the adherent, but not the non-adherent spleen cell population and was found to be radioresistant. It is concluded that macrophages are directly involved in the adjuvant effect of C. parvum and the possible mechanisms of action are discussed.
D000276:Adjuvants, Immunologic; D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis*; D000917:Antibody Formation; D000921:Antibody-Producing Cells; D000941:Antigens; D002448:Cell Adhesion; D004140:Dinitrophenols; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006462:Hemolytic Plaque Technique; D066298:In Vitro Techniques; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D008808:Mice, Inbred CBA; D011425:Propionibacterium acnes / Q000276:immunology*; D011830:Radiation Effects; D013154:Spleen / Q000166:cytology / Q000528:radiation effects
D000276:Adjuvants, Immunologic; D000907:Antibodies, Bacterial; D000941:Antigens; D004140:Dinitrophenols