Structural, antigenic, and biological characteristics of precancerous mastopathy.
A biologically significant relationship between precancerous mastopathy (PCM), in situ carcinoma (ISC), and invasive breast carcinoma is evidenced by the following: (a) PCM and ISC are commonly associated with each other and with invasive breast cancer; (b) Stage O PCM and ISC are both associated with an increased risk of subsequent breast cancer; (c) patients with Stage O PCM and ISC are more similar to invasive breast cancer patients than to patients with normotypic breast lesions in regard to family history of breast cancer and parity characteristics; (d) PCM and ISC resemble invasive breast cancers and differ from normotypic mammary epithelium in regard to epithelial cell-lymphoreticuloendothelial relationships; (e) PCM and, particularly, ISC are associated with distinctive immunogenic components; (f) prognostically significant immunogens of invasive breast cancer tissues are related to and antigenically similar to immunogenic components of associated ISC; (g) immunogenic cancers (ISC and invasive) from different patients are antigenically similar to one another; (h) immunogenic cancers (ISC and invasive) from different patients are antigenically similar to some component of murine mammary tumor virus.
D000328:Adult; D000367:Age Factors; D000917:Antibody Formation; D015478:Antigens, Heterophile; D000951:Antigens, Neoplasm; D001943:Breast Neoplasms / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D005191:Family Characteristics; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000503:physiopathology; D007158:Immunologic Techniques; D008198:Lymph Nodes / Q000503:physiopathology; D008208:Lymphatic System / Q000503:physiopathology; D008214:Lymphocytes / Q000502:physiology; D008407:Mast Cells / Q000502:physiology; D008875:Middle Aged; D010298:Parity; D011230:Precancerous Conditions / Q000276:immunology* / Q000473:pathology; D012306:Risk
D015478:Antigens, Heterophile; D000951:Antigens, Neoplasm