Antimalarials. 9. Methylthio- and methylsulfonyl-substituted 9-phenanthrenemethanols.
Nine di- and trisubstituted 9-phenanthrenemethanols bearing methylthio and methylfulfonyl substituents in the 2 and/or 6 positions of the phenanthrene nucleus were prepared and screened for antimalarial activity against Plasmodium berghei in mice. Six of the nine compounds were curative at or below 160 mg/kg. The most active structures contained a methylthio substituent in combination with two chlorine atoms.
D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000627:therapeutic use; D008288:Malaria / Q000188:drug therapy; D051379:Mice; D010616:Phenanthrenes / Q000138:chemical synthesis* / Q000627:therapeutic use; D010962:Plasmodium berghei; D013440:Sulfides / Q000138:chemical synthesis / Q000627:therapeutic use; D013450:Sulfones / Q000138:chemical synthesis / Q000627:therapeutic use
D000962:Antimalarials; D010616:Phenanthrenes; D013440:Sulfides; D013450:Sulfones