Direct evidence for a bone marrow origin of the alveolar macrophage in man.
Alveolar macrophages were obtained from 23 patients who had received marrow transplants for hematologic disorders. The presence of a Y body in macrophages of male origin was demonstrated by fluorescence microscopy. In those patients with a marrow donor of opposite sex the alveolar macrophages were shown to be of donor origin. The disappearance with time of host macrophages indicates a life-span, under the conditions, of approximately 81 days.
D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D002454:Cell Differentiation; D005260:Female; D006801:Humans; D007621:Karyotyping; D008264:Macrophages / Q000166:cytology*; D008297:Male; D012730:Sex Chromosomes; D013997:Time Factors; D014184:Transplantation, Homologous