title: [Clinical evaluation of tetraaolean: comparative studies with tetracycline].
abstract: The results from the comparative clinical studies on the effectiveness of tetraolean and tetracycline are summed up about 1672 patients with acute and exacerbated infections of the respiratory organs (1036 patient, treated by ten teams, working on the theme given in advance "Comparative clinical studies between tetraolean and tetracyclin in acute pneumonia", 164 patients with postgrippe viral-bacterial pneumonia, treated during the grippe epidemy 1972/1973 and 445 patient treated at the Therapeutic Clinic, Sofia during 1967-1972). The total results reveal that, according to the adopted objective indices, the therapeutic effect of tetraolean is with a statistically significant superiority over tetracyclin. The beneficial results obtained in the treatment of 14 patients with endocarditis lenta are also reported. The mechanisms of that superior effect, defined as "clinical synergism" are discussed.
mesh_terms: D000208:Acute Disease; D002031:Bulgaria; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D004338:Drug Combinations; D004341:Drug Evaluation; D004698:Endocarditis, Subacute Bacterial / Q000188:drug therapy; D006801:Humans; D007251:Influenza, Human / Q000188:drug therapy; D008171:Lung Diseases / Q000188:drug therapy; D009827:Oleandomycin / Q000627:therapeutic use*; D011014:Pneumonia / Q000188:drug therapy; D013752:Tetracycline / Q000627:therapeutic use*
chemical_list: D004338:Drug Combinations; D013752:Tetracycline; D009827:Oleandomycin
vernacular_title: Klinichna otsenka na tetraoleana--sravnitelni prouchvaniia s tetratsiklin