title: [The allergic focal reaction phenomenon. Significance for the testing, therapy and theory of clinical allergy. Study in bronchial asthma and other allergic diseases].
abstract: On the basis of examinations of 654 cases of clinical allergy (487 cases of bronchial asthma) a new allergenic phenomenon is described: "The allergic focal reaction phenomenon". It is associated with the demonstration of a regularly reproducible, clinical, allergic initiating effect of very small doses of specific antigen only on the allergically diseased tissue (focus). The findings made it possible to elaborate a new method for allergy testing and therapy without any danger, and offers quite new ideas for the interpretation of allergic mechanisms. The authors tried to integrate this phenomenon into the picture of clinical allergy, and some so far unclear problems of allergy may, on this basis, have found a probable solution."
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000937:Antigen-Antibody Reactions; D000941:Antigens; D000942:Antigens, Bacterial; D001249:Asthma / Q000276:immunology*; D001991:Bronchitis / Q000276:immunology; D002648:Child; D004646:Emphysema / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D007158:Immunologic Techniques / Q000379:methods; D008875:Middle Aged; D011656:Pulmonary Emphysema / Q000276:immunology; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology; D013997:Time Factors
chemical_list: D000941:Antigens; D000942:Antigens, Bacterial
vernacular_title: Das allergische Fokalreaktionsphänomen. Seine Bedeutung für Testung, Therapie und Theorie der klinischen Allergie. Untersuchungen am Bronchialasthma und verwandten allergischen Erkrankungen