The immunology of the insulin receptor.
We have detected and characterized anti-insulin-receptor autoantibodies which circulate in several patients with insulin resistance diabetes. These antibodies are predominantly IgG and are polyclonal. They inhibit insulin binding to its receptor on a variety of tissues from widely separated species. Antibodies obtained from different patients appear to bind to different determinants on the receptor and alter receptor function in several ways. Some anti-receptor antibodies are capable of stimulating insulin-like effects on target tissues, while others block insulin-stimulated effects. Direct labeling of anti-receptor antibody with 125I permits use of these antibodies as an assay and probe of insulin receptors.
D000273:Adipose Tissue / Q000166:cytology; D000818:Animals; D000918:Antibody Specificity; D001323:Autoantibodies / Q000032:analysis*; D001666:Binding Sites, Antibody; D001667:Binding, Competitive; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007333:Insulin Resistance; D051381:Rats; D013577:Syndrome
D001323:Autoantibodies; D007074:Immunoglobulin G