Effect of oil-attached BCG cell-wall skeleton on the induction of pleural fibrosarcomas in mice.
The effect of oil-attached BCG cell-wall skeleton on the induction of pleural fibrosarcomas by 3-methylcholanthrene in mice was examined. The pleural fibrosarcomas were induced by a substernal injection of 3-methylcholanthrene into the thoracic cavity of ddO mice. One week after the injection of 3-methylcholanthrene, 100 mug of oil-attached BCG cell-wall skeleton was injected subcutaneously every week for 10 weeks. In the observation period of 130 days, the incidence of pleural fibrosarcoma was 67% in the control mice and 39% in the mice treated with BCG cell-wall skeleton. The latent period of tumor induction was prolonged in the mice treated with BCG cell-wall skeleton.
D000818:Animals; D001500:BCG Vaccine; D002473:Cell Wall / Q000276:immunology; D005260:Female; D005354:Fibrosarcoma / Q000139:chemically induced / Q000276:immunology* / Q000473:pathology; D008297:Male; D008748:Methylcholanthrene; D051379:Mice; D009163:Mycobacterium bovis / Q000276:immunology* / Q000648:ultrastructure; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000276:immunology / Q000473:pathology; D009821:Oils; D014677:Pharmaceutical Vehicles; D010997:Pleural Neoplasms / Q000139:chemically induced / Q000276:immunology* / Q000473:pathology
D001500:BCG Vaccine; D009821:Oils; D014677:Pharmaceutical Vehicles; D008748:Methylcholanthrene