title: [Antibacterial activity of the derivatives of dehydro-and deoxy-colic acids (author's transl)].
abstract: The synthesis of derivatives of dehydro-and deoxy-colic acids with L-lysine and Lysil-lysine with antibacterial activity, is here described. Results show no antibacterial activity of dehydrocolic acid derivatives, while deoxycol-lys-OH-HCl, and particularly deoxycol-lys-NH2-2HCl, seem to be very effective on Gram-positive bacteria at 5 mug/ml, and on Gram-negatives at 25 mug/ml.
mesh_terms: D001419:Bacteria / Q000187:drug effects*; D003685:Dehydrocholic Acid / Q000031:analogs & derivatives / Q000494:pharmacology*; D003840:Deoxycholic Acid / Q000031:analogs & derivatives / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011514:Proteus vulgaris / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013297:Streptococcus pyogenes / Q000187:drug effects
chemical_list: D003840:Deoxycholic Acid; D003685:Dehydrocholic Acid
vernacular_title: Attivita' antimicrobica di derivati degli acidi deidro- e desossi-colico