title: Dialyzable transfer factor in the treatment of human osteosarcoma: an analytic review.
abstract: In conclusion, then, we would answer the seven questions raised earlier concerning transfer factor as follows: Certianly, as shown by clinical results, it does exist. It does have a definite immunologic effect in humans, boosting cell-mediated immunity, as shown by a rise in the level of active T cells. Its clinical effects have been demonstrated repeatedly, and it should become useful in still other clinical situations as further research provides more effective therapeutic modalities. Transfer factor from selected donors appears to provide prophylaxis against metastasis when administered to osteosarcoma patients with no clinically evident metastases at the time of surgical removal of the primary tumor; whether this treatment is superior to chemotherapeutic prophylaxis is conjectural and controversial. Its mechanism of action has not been demonstrated as yet, although many theories exist. The best evidence is that the effects are both specific and nonspecific. It appears to be produced by T lymphocytes. The exact nature of the substance we call "transfer factor" remains to be elucidated. Further research should provide more conclusive answers to these questions.
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001681:Biological Assay; D001859:Bone Neoplasms / Q000276:immunology / Q000517:prevention & control / Q000628:therapy*; D002457:Cell Extracts; D005591:Chemical Fractionation; D055598:Chemical Phenomena; D002621:Chemistry; D003601:Cytotoxicity Tests, Immunologic; D003956:Dialysis; D004317:Doxorubicin / Q000627:therapeutic use; D006801:Humans; D007111:Immunity, Cellular; D008727:Methotrexate / Q000627:therapeutic use; D012516:Osteosarcoma / Q000276:immunology / Q000517:prevention & control / Q000628:therapy*; D013601:T-Lymphocytes / Q000276:immunology; D014165:Transfer Factor / Q000627:therapeutic use*; D014374:Tuberculin Test
chemical_list: D000970:Antineoplastic Agents; D002457:Cell Extracts; D014165:Transfer Factor; D004317:Doxorubicin; D008727:Methotrexate