[Acebutolol test in moderate arterial hypertension. Action on systolic time intervals].
The antihypertensive effect of acebutolol, a new cardioselective beta-blocking drug, is studied in 31 patients with mild essential hypertension. Administration of acebutolol (2,000 mg) in 48 hours produced a significant decrease in blood pressure, heart rate, plasma renin activity (P.R.A.) and an increase in systolic time intervals (pre-ejection period and isovolumetric contraction time). The blood pressure drop is highly correlated to the initial P.R.A. values, but is not related either to the initial heart rate, or to the systolic time intervals values.
D000070:Acebutolol / Q000494:pharmacology / Q000627:therapeutic use*; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008875:Middle Aged; D011674:Pulse / Q000187:drug effects; D012083:Renin / Q000097:blood
D000070:Acebutolol; D012083:Renin
Le test à l'acébutolol dans l'hypertension artérielle modérée. Action sur les intervalles de temps systoliques