title: Cutaneous basophil hypersensitivity.
abstract: Cutaneous basophil hypersensitivity (CBH) is a distinct form of lymphocyte-mediated hypersensitivity in guinea pigs, separate both from classic delayed hypersensitivity (DH) and from the well-known antibody-mediated reactions. CBH, not DH, is the usual cellular immune response of this species to a wide variety of immunogens (e.g., allografts, certain parasites, and viruses) when these are presented in native form without supplementation with mycobacteria-containing adjuvants, thus attesting to the importance of this response in the guinea pig's overall immune defense mechanism. Basophil-containing, cell-mediated, delayed-onset reactions occur in other species, including man, as well.
mesh_terms: D000818:Animals; D000918:Antibody Specificity; D001491:Basophils / Q000276:immunology*; D002199:Capillary Permeability; D005337:Fibrin / Q000378:metabolism; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000276:immunology* / Q000473:pathology; D007111:Immunity, Cellular; D007116:Immunization, Passive; D008214:Lymphocytes / Q000276:immunology; D008407:Mast Cells / Q000276:immunology; D009928:Organ Specificity; D013045:Species Specificity
chemical_list: D005337:Fibrin