Bacterial renal infection in rats produced by direct injection of bacteria into renal tissue--an experimental model.
A new method for producing an experimental model of renal infection in rats is described. It is based on a direct injection of a concentrated E. coli suspension either into both kidneys or only one of them. The method is simple and takes little time; the mortality of experimental animals is low. A focal acute purulent renal inflammation is elicited which tends to propagate towards the papilla. A significant renal infection persists at least over six weeks. The renal infection model is suitable for testing the antibacterial activities of drugs, as documented by the results of a therapeutical experiment with gentamicin and other agents.
D000818:Animals; D004195:Disease Models, Animal; D004927:Escherichia coli Infections / Q000188:drug therapy / Q000473:pathology; D005260:Female; D005839:Gentamicins / Q000627:therapeutic use; D007668:Kidney / Q000382:microbiology* / Q000473:pathology; D007674:Kidney Diseases / Q000382:microbiology* / Q000473:pathology; D051381:Rats; D013535:Suspensions; D014552:Urinary Tract Infections / Q000188:drug therapy / Q000382:microbiology
D005839:Gentamicins; D013535:Suspensions