[Action of pyridinol carbamate on hetero-immune Masugi nephritis in the rat (author's transl)].
Pyridinol-carbamate (P.C.) is a new substance with various properties including an anti-inflammatory (anti-kinin) and an antiplatelet aggregation activity. Since a coagulation process has been demonstrated in Masugi nephritis in Rats, we investigated the effect of P.C. in this experimental model. P.C. (150 mg/kg/day) was given orally from day 1 to day 28. It prevented partially the G.N.: proteinuria was significantly lower than in nephritic untreated animals with a reduction of seromucoid blood levels and B.U.N. Histological examination revealed that glomerular injury was limited in treated animals specially with regards to G.B.M. alterations and deposits.
D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects; D002219:Carbamates / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005921:Glomerulonephritis / Q000276:immunology / Q000517:prevention & control*; D007106:Immune Sera; D009088:Mucoproteins / Q000097:blood; D010974:Platelet Aggregation / Q000187:drug effects; D011507:Proteinuria / Q000209:etiology; D011727:Pyridinolcarbamate / Q000627:therapeutic use*; D011817:Rabbits; D051381:Rats; D014508:Urea / Q000097:blood
D002219:Carbamates; D007106:Immune Sera; D009088:Mucoproteins; D011727:Pyridinolcarbamate; D014508:Urea
Action du pyridinol-carbamate sur la néphrite hétéro-immune de Masugi du rat