Further study on pharmacology of meclophenoxate and it components in mice.
The effects of three-day treatment with meclophenoxate (Centrophenoxin) and its components, p-chlorophenoxyacetic acid and dimethylaminoethanol, on the aggressiveness and pain threshold in mice were investigated. p-Chlorophenoxyacetic acid increased the aggressiveness and pain sensitivity. Dimethylaminoethanol, on the contrary, tended to decrease these items of behaviour. The effects of meclophenoxate reflected this reciprocal activity of components, the activity of p-chlorophenoxyacetic acid prevailing. The results are taken as the evidence of some slowly developing mechanism in the activity of p-chlorophenoxyacetic acid, responsible for some of the effects of meclophenoxate. A possible mode of action of p-chlorophenoxyacetic acid is suggested.
D000374:Aggression / Q000187:drug effects; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003642:Deanol / Q000494:pharmacology; D006016:Glycolates / Q000494:pharmacology*; D006801:Humans; D008297:Male; D002504:Meclofenoxate / Q000494:pharmacology*; D051379:Mice; D010146:Pain / Q000503:physiopathology; D010642:Phenoxyacetates / Q000494:pharmacology; D013997:Time Factors; D014828:Vocalization, Animal / Q000187:drug effects
D006016:Glycolates; D010642:Phenoxyacetates; D003642:Deanol; D002504:Meclofenoxate