title: The effects of pentobarbital and ether anesthesia on hypothalamic LH-RH in the rat.
abstract: The effects of ether and pentobarbital anesthesia on hypothalamic and cerebrospinal fluid (CSF) LH-RH content were studied in male rats. Ether elevated hypothalamic LH-RH 30 min after a 3-min exposure; pentobarbital (30 mg/kgital (30mg/kg) caused no change. The ether-induced increase in LH-RH content was not affected by pretreatment with pentobarbital; however, the increase was abolished in animals subjected to hypothalamic deafferentation. Changes in CSF LH-RH generally paralleled the hypothalamic changes; ether, for example, elicited a significant rise. These results demonstrate the complex hypothalamo-pituitary-CSF interactions which occur in response to general anesthetics.
mesh_terms: D000818:Animals; D004347:Drug Interactions; D004986:Ether / Q000494:pharmacology*; D005019:Ethyl Ethers / Q000494:pharmacology*; D007987:Gonadotropin-Releasing Hormone / Q000134:cerebrospinal fluid / Q000378:metabolism*; D007031:Hypothalamus / Q000187:drug effects* / Q000378:metabolism; D066298:In Vitro Techniques; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D008473:Median Eminence / Q000187:drug effects / Q000378:metabolism; D009475:Neurons, Afferent / Q000502:physiology; D010424:Pentobarbital / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D005019:Ethyl Ethers; D004986:Ether; D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D010424:Pentobarbital