[Construction of new types of chemical vaccines for the prevention of intestinal infections, and their qualitative assessment. IV. Physical properties and immunological characteristics of the experimental series of chemical vaccines presented for comparative study].
The authors present the results of study of physico-chemical properties of the chemical sorbed monovaccines from the antigens of the causative agents of typhoid fever, paratyphoid A and B and Sonne and Flexner dysentery obtained by various methods; the results of investigation of their reactogenic properties and immunological activity of limited groups of volunteers also given. The vaccines from the antigens obtained by sparing methods were less reactogenic than the rest experimental and control vaccines obtained from the tryptic antigens. The majority of the experimental vaccines caused a significant increase of the specific antibody titres in the sera of the vaccinated persons: typhoid vaccines--of the O-, VI- and H-antibodies, paratyphoid B vaccines--of the O- and H-antibodies; the control vaccines from the tryptic antigens failed to induce the H-antibody synteisis in the vaccinated persons. Experimental dysentery monovaccines induced a greater increase in the antibody titres than the control vaccines.
D000907:Antibodies, Bacterial / Q000032:analysis; D000917:Antibody Formation; D001428:Bacterial Vaccines; D005069:Evaluation Studies as Topic; D006801:Humans; D007120:Immunochemistry; D012482:Salmonella paratyphi A / Q000276:immunology*; D012485:Salmonella typhi / Q000276:immunology*; D012763:Shigella flexneri / Q000276:immunology; D012764:Shigella sonnei / Q000276:immunology*; D014436:Typhoid-Paratyphoid Vaccines
D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D014436:Typhoid-Paratyphoid Vaccines
Konstruirovanie noykh tipov khimicheskikh vaktsin dlia profilaktiki kishechnykh infektsii i ikh kachestvennaia otsenka. Soobshchenie IV. Fizicheskie svoistva i immunollgicheskaia kharakteristika eksperimental'nykh serii khimicheskikh vaktsin, predstavlennykh dlia sravnitel'nogo izucheniia