title: Delayed progression of diabetic retinopathy by divided insulin administration: a further follow-up.
abstract: We have previously reported a slower rate of progression in the number of microaneurysms in insulin dependent diabetic patients treated by divided insulin injections when compared to patients receiving a single daily insulin injection [Diabetes 25, 463--469 (1976)]. This observation is strengthened by the present analysis which uses complementary data obtained after a further year follow up: the mean yearly increase in the number of microaneurysms was 9 +/- 1 in the single injection group and 3 +/- 1 in the multiple one (p less than 0.001).
mesh_terms: D000783:Aneurysm / Q000188:drug therapy / Q000209:etiology; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D003930:Diabetic Retinopathy / Q000188:drug therapy* / Q000503:physiopathology; D004334:Drug Administration Schedule; D005500:Follow-Up Studies; D006029:Glycosuria; D006801:Humans; D007328:Insulin / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D001786:Blood Glucose; D007328:Insulin