Modulation of the hexose induced suppression of glucagon secretion by somatostatin on isolated pancreatic rat islets.
Somatostatin inhibits in a dose-dependent manner the glucagon secretion in the presence of up to 5 mM glucose, whereas the suppressed glucagon release in the presence of greater than or equal to 10 mM glucose, 10 mM glyceraldehyde, 30 mM fructose or 30 mM mannose is characterized by an increase of hormone release under the influence of somatostatin.
D000818:Animals; D005632:Fructose / Q000494:pharmacology; D005934:Glucagon / Q000378:metabolism*; D005947:Glucose / Q000494:pharmacology; D005985:Glyceraldehyde / Q000494:pharmacology; D006601:Hexoses / Q000494:pharmacology*; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D008358:Mannose / Q000494:pharmacology; D008757:Methylglucosides / Q000494:pharmacology; D051381:Rats; D013004:Somatostatin / Q000494:pharmacology*
D006601:Hexoses; D008757:Methylglucosides; D005632:Fructose; D005985:Glyceraldehyde; D013004:Somatostatin; D005934:Glucagon; D005947:Glucose; D008358:Mannose