Histopathological and pharmacological studies on the action of a new anti-inflammatory agent (BR 700).
The effect of a new anti-inflammatory agent, 2-phenyl-4-p-chlorophenyl-thiazol-5-ylacetic acid (BR 700) on the development of cover slip granuloma was studied. The drug decreased macrophage emigration and delayed some characteristic processes of the mononuclear cells.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003907:Dexamethasone / Q000494:pharmacology; D005260:Female; D005549:Foreign-Body Reaction; D006099:Granuloma / Q000188:drug therapy / Q000473:pathology*; D008214:Lymphocytes / Q000473:pathology; D008264:Macrophages / Q000473:pathology; D009000:Monocytes / Q000473:pathology; D009504:Neutrophils / Q000473:pathology; D051381:Rats; D013844:Thiazoles / Q000494:pharmacology* / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D013844:Thiazoles; D003907:Dexamethasone