title: Developments in delayed-type hypersensitivities: 1950-1975.
abstract: Significant developments during the last 25 years are discussed and interpreted. The following areas of delayed hypersensitivity are included: the mode of active sensitization to simple allergenic chemicals; evidence for anamnestic responses; cell types and cell-cell interactions via lymphokines; function of skin and lymphatics, and the role of the carrier in initial sensitization to allergenic chemicals; acquired tolerance; transfer factor. Some prognostications for the future are attempted.
mesh_terms: D000596:Amino Acids / Q000627:therapeutic use; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D003876:Dermatitis, Atopic / Q000276:immunology; D003877:Dermatitis, Contact / Q000276:immunology; D004137:Dinitrochlorobenzene / Q000627:therapeutic use; D004140:Dinitrophenols / Q000627:therapeutic use; D005620:Freund's Adjuvant / Q000627:therapeutic use; D006241:Haptens; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology / Q000628:therapy; D007108:Immune Tolerance; D007114:Immunization; D007156:Immunologic Memory; D008208:Lymphatic System / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D010853:Picryl Chloride / Q000627:therapeutic use; D012867:Skin / Q000276:immunology; D012882:Skin Tests; D013601:T-Lymphocytes / Q000276:immunology; D014165:Transfer Factor / Q000627:therapeutic use
chemical_list: D000596:Amino Acids; D004137:Dinitrochlorobenzene; D004140:Dinitrophenols; D006241:Haptens; D014165:Transfer Factor; D005620:Freund's Adjuvant; D010853:Picryl Chloride