title: The fine structure of human chromosomes isolated by shearing-sieving.
abstract: Chromosomes isolated by the new technique of shearing-sieving, even if unstained, show a less degraded organisation than those prepared for the electron microscope by other techniques. The chromosomes are banded, may show more bands if stretched, and the centromere is a precisely defined structure. Appearances resulting from this technique are compared with those from other techniques.
mesh_terms: D002875:Chromosomes / Q000648:ultrastructure*; D003584:Cytological Techniques; D006801:Humans; D066298:In Vitro Techniques; D008854:Microscopy, Electron