Effect of 13-Nle-motilin in postoperative ileus patients: a double-blind trial.
In this study, the effect of 13-norleucine motilin (13-Nle-M) on post-cholecystectomy ileus was assessed in 6 female patients. 13-Nle-M given by continuous i.v. infusion (0.4 mug/kg-h) on the second and third day following surgery did not influence the manifestation and duration of intestinal paralysis in comparison to 6 control patients treated with 0.9% saline. Bowel sounds, however, were more pronounced in the 13-Nle-M-group. Blood pressure and pulse rate were not influenced by the polypeptide, and no other side effects were seen, either.
D000328:Adult; D000368:Aged; D002763:Cholecystectomy; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D005260:Female; D005768:Gastrointestinal Hormones / Q000627:therapeutic use*; D006801:Humans; D007415:Intestinal Obstruction / Q000188:drug therapy*; D007418:Intestinal Pseudo-Obstruction / Q000188:drug therapy* / Q000209:etiology; D008875:Middle Aged; D009037:Motilin / Q000031:analogs & derivatives / Q000627:therapeutic use*; D010919:Placebos; D011183:Postoperative Complications / Q000188:drug therapy*
D005768:Gastrointestinal Hormones; D010919:Placebos; D009037:Motilin