Structure-function relationship: immunologic.
It is suggested that the antigenic site of glucagon for the specific sera is located within the 24-29 section of the molecule and within the 2-23 section for the fully cross-reacting sera. Biologically inactivated glucagon may retain immunoreactivity in spite of the loss of receptor-binding activity.
D000818:Animals; D000937:Antigen-Antibody Reactions; D003429:Cross Reactions; D005934:Glucagon / Q000031:analogs & derivatives / Q000276:immunology*; D007106:Immune Sera; D007422:Intestines; D007515:Islets of Langerhans; D010446:Peptide Fragments / Q000276:immunology; D013045:Species Specificity; D013329:Structure-Activity Relationship
D007106:Immune Sera; D010446:Peptide Fragments; D005934:Glucagon