[Effect of streptomycin on RNA synthesis in E. coli cells].
Under streptomicin administration (10-200 mug/ml), initiation of translation is blocked at any steps before the formation of tightly bound subunits. Incomplete supression of protein synthesis with streptomycin stimulate rRNA synthesis in rel+ CP78 E. coli cells. Thus, partial uncoupling of translocation and transcription promotes compensatory synthesis of rRNA synthesis directed by rel-gene, but on addition to pre-starved cells, antibiotic can not stimulate rRNA formation. It is shown, that in contrast with many other ribosomal antibiotics streptomycin do not penetrate into the cell during aminoacid starvation.
D004926:Escherichia coli / Q000187:drug effects* / Q000378:metabolism; D012329:RNA, Bacterial / Q000096:biosynthesis*; D012270:Ribosomes / Q000187:drug effects; D013307:Streptomycin / Q000494:pharmacology*
D012329:RNA, Bacterial; D013307:Streptomycin
Vliianie streptomitsine na sintez RNK v kletkakh E. coli