Generic inequivalence between two brands of chloramphenicol capsule.
Generic inequivalence between two brands of chloramphenicol capsules has been investigated. Both brands complied with official standards for drug content and capsule disintegration time, and exhibited similar anti-bacterial activity when tested in vitro. A slow dissolution rate was observed with one brand which could be related to a formulation defect which might explain reported therapeutic inefficacy.
D002214:Capsules / Q000032:analysis; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002701:Chloramphenicol / Q000032:analysis / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D012995:Solubility; D013810:Therapeutic Equivalency; D013997:Time Factors
D002214:Capsules; D002701:Chloramphenicol