Immune response to phi X 174 in man. 5. Primary and secondary antibody production in primary biliary cirrhosis.
In primary biliary cirrhosis, the primary immune response to the bacteriophage phi X 174 is normal but the secondary response is significantly reduced. The reduction is primarily of IgG antibody, while IgM is proportionately less affected. These changes may be the result of a reduction in helper T lymphocyte function and may contribute to the increase in the ratio of serum concentration of IgM to IgG.
D000328:Adult; D000368:Aged; D000917:Antibody Formation; D000956:Antigens, Viral / Q000008:administration & dosage; D003090:Coliphages / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007158:Immunologic Techniques; D008105:Liver Cirrhosis, Biliary / Q000276:immunology*; D008213:Lymphocyte Activation; D008875:Middle Aged
D000956:Antigens, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M