Sterculia bulk-forming agent with smooth-muscle relaxant versus bran in diverticular disease.
Sterculia with and without a smooth-muscle relaxant (alverine citrate) had similar beneficial effects on constipation and reduced the transit times in diverticular disease. Intracolonic pressure, however, varied with the preparation used. Though both preparations relieved the symptoms of diverticular disease, the one containing alverine citrate was more effective. Part of the mode of action of bran may be to relax the smooth muscle of the gut, since its actions were more comparable to those of sterculia plus alverine citrate than to those of sterculia alone.
D002986:Clinical Trials as Topic; D003106:Colon / Q000187:drug effects; D003248:Constipation / Q000188:drug therapy; D004239:Diverticulitis, Colonic / Q000178:diet therapy / Q000188:drug therapy*; D002523:Edible Grain; D005769:Gastrointestinal Motility / Q000187:drug effects; D006801:Humans; D009130:Muscle, Smooth / Q000187:drug effects; D010276:Parasympatholytics / Q000627:therapeutic use*; D010936:Plant Extracts / Q000627:therapeutic use*; D011312:Pressure; D011437:Propylamines / Q000627:therapeutic use*; D012116:Resins, Plant / Q000627:therapeutic use*
D010276:Parasympatholytics; D010936:Plant Extracts; D011437:Propylamines; D012116:Resins, Plant; C010846:alverine