[Therapeutic results with the combination pramiverine/metamizole in a multicentre trial (author's transl)].
279 physicians took part in a multicentre trial to assess the efficacy and acceptability of the combination of 4,4-diphenyl-N-isopropyl-cyclohexylamine-hydrochloride (pramiverine, Sistalgin) and N-methyl-N-(2,3-dimethyl-5-oxo-1-phenyl-3-pyrazolin-4-yl)-aminomethanesulfonate (metamizole) (Sistalgin comp) in the forms of ampoules, coated tablets and suppositories. 1301 out of 1329 case reports could be evaluated; in 28 cases treatment was discontinued. The trial included 59% acute colics and 41% subacute recurrent painful spasms of the caval organs. A single presentation form was used in 44%; all other patients were treated with the combined regimen of ampoules/coated tablets/suppositories. A good or very good result was obtained in 91% of cases, with a low rate of undesired side-effects. In 3%, the result was unsatisfactory. The patients' judgment was in agreement with that of the physician. Both judgments confirmed the rapid onset, long duration and reliable effect of pramiverine/metamizole in treating colics of the intestinal, biliary and urinary tracts as well as recurrent spastic pain. Similarly favourable results were obtained with all presentation forms.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000632:Aminopyrine / Q000031:analogs & derivatives*; D001559:Benzhydryl Compounds / Q000009:adverse effects / Q000627:therapeutic use; D001660:Biliary Tract Diseases / Q000188:drug therapy; D002648:Child; D002986:Clinical Trials as Topic; D003085:Colic / Q000188:drug therapy*; D003514:Cyclohexylamines / Q000009:adverse effects / Q000627:therapeutic use*; D004177:Dipyrone / Q000009:adverse effects / Q000627:therapeutic use*; D004338:Drug Combinations; D004412:Dysmenorrhea / Q000188:drug therapy; D005260:Female; D005767:Gastrointestinal Diseases / Q000188:drug therapy; D006801:Humans; D008875:Middle Aged; D010276:Parasympatholytics / Q000009:adverse effects / Q000627:therapeutic use*; D013035:Spasm / Q000188:drug therapy*; D014570:Urologic Diseases / Q000188:drug therapy
D001559:Benzhydryl Compounds; D003514:Cyclohexylamines; D004338:Drug Combinations; D010276:Parasympatholytics; D000632:Aminopyrine; D004177:Dipyrone
Therapieergebnisse mit der Kombination Pramiverin/metamizol in einem Feldversuch