title: Chronic neutropenia in childhood. Analysis of 16 cases and a review of the literature.
abstract: We analyzed the clinical histories and hematologic information concerning 16 persons in whom chronic neutropenia was discovered early in life. Only two of them, those with the lowest mean neutrophil counts, had frequent and severe pyogenic infections. Almost all the infections were caused by Staphylococcus aureus or by enteric microorganisms and involved the skin, respiratory tract or gastrointestinal system. The prognosis in our subjects or in patients described in the literature could not be predicted from the bone marrow morphology, presence or absence of blood monocytosis, pattern of genetic transmission or results of special tests of neutrophil function. We propose that the complex nomenclature associated with chronic neutropenic states be discarded until a better basis for classification becomes available.
mesh_terms: D000293:Adolescent; D000328:Adult; D000380:Agranulocytosis / Q000209:etiology*; D001424:Bacterial Infections / Q000150:complications*; D001856:Bone Marrow Examination; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D005799:Genes, Dominant; D005808:Genes, Recessive; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009000:Monocytes; D009503:Neutropenia / Q000150:complications / Q000209:etiology* / Q000235:genetics; D010033:Otitis Media / Q000150:complications; D011014:Pneumonia / Q000150:complications; D011379:Prognosis; D011711:Pyoderma / Q000150:complications; D009626:Terminology as Topic