Evidence for a selective cytotoxic effect of carrageenan on cells of the immune system in vivo and in vitro.
Carrageenan suppressed antibody production to sheep erythrocytes in the mouse only when injected together with or 24 h prior to antigen. Pretreatment of sensitized spleen cell cultures with carrageenan reduced the degree of stimulation obtained using antigen but not PHA.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D002351:Carrageenan / Q000494:pharmacology*; D003601:Cytotoxicity Tests, Immunologic; D004912:Erythrocytes / Q000276:immunology*; D006462:Hemolytic Plaque Technique; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D051379:Mice; D013154:Spleen / Q000166:cytology; D013997:Time Factors
D007075:Immunoglobulin M; D002351:Carrageenan