Studies on the immunosuppressive and anti-inflammatory action of L-asparaginase.
The influence of L-asparaginase (Crasnitin) on cellular reactions in the course of immunologically specific and nonspecific processes was studied. The preparation exerted particularly strong inhibitory action on the appearance of hemolysin-producing cells (Jerne's test) and on formation of rosette forms. A somewhat weaker effect on nonspecific inflammatory reactions, by the xylene and granulation tests, was noted. It was concluded that L-asparaginase depresses cellular reactions regardless of their immunologic component, but that immunologic reactions are more sensitive to this drug. It was established that L-asparaginase acts on bursal and thymus-dependent lymphocytes and, moreover, influences the hyperemic and proliferative reactions that accompany immunologically nonspecific processes.
D000818:Animals; D000893:Anti-Inflammatory Agents; D001215:Asparaginase / Q000494:pharmacology*; D001402:B-Lymphocytes / Q000187:drug effects; D005260:Female; D006462:Hemolytic Plaque Technique; D007104:Immune Adherence Reaction; D007111:Immunity, Cellular / Q000187:drug effects; D007166:Immunosuppressive Agents; D008297:Male; D051379:Mice; D013601:T-Lymphocytes / Q000187:drug effects
D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D001215:Asparaginase