Cellular immunity to lymphocyte antigens in human infertility.
The leukocyte migration test was used to detect cellular immunity to HL-A antigens present on the husband's lymphocytes and spermatozoa in a group of fertile and infertile couples. Approximately 50% of the married female population appear to be sensitized. There was no difference between the fertile and infertile groups in the frequency of positive results, but a greater number of migration indices were below 0.7 and 0.6 in the infertile group. It is suggested that sperm cells are the most likely cause of immunization.
D002464:Cell Migration Inhibition; D002986:Clinical Trials as Topic; D005260:Female; D006680:HLA Antigens; D006801:Humans; D007111:Immunity, Cellular; D007246:Infertility / Q000276:immunology*; D008297:Male; D013094:Spermatozoa / Q000276:immunology*
D006680:HLA Antigens