Amyloid-related serum protein SAA in endotoxin-induced amyloidosis of the mink.
The concentration of the amyloid AA-related serum protein (SAA) was markedly increased after endotoxin injections in mink, mouse, rabbit, and man. It was particularly studied during the development of endotoxin-induced amyloidosis of the mink. Protein SAA was markedly elevated in all mink 24 h after the first endotoxin injection but had fallen to relatively low levels before the onset of amyloidosis at about 4 wk. These results are consistent with SAA being a circulating precursor of the amyloid fibril protein, AA. However, both proteins may be derived by proteolysis from a common precursor.
D000682:Amyloid / Q000097:blood*; D000686:Amyloidosis / Q000097:blood* / Q000209:etiology; D000818:Animals; D004195:Disease Models, Animal; D004731:Endotoxins; D004926:Escherichia coli; D005260:Female; D008297:Male; D008907:Mink; D011498:Protein Precursors / Q000097:blood*; D013997:Time Factors
D000682:Amyloid; D004731:Endotoxins; D011498:Protein Precursors