Immunogenicity of a rat leukaemia of spontaneous origin (SAL).
The SAL rat leukaemia, which resembles acute myeloblastic leukaemia, appeared initially to be non-immunogenic since resistance to an i.p. challenge with as few as 100 cells could not be obtained using stimulation of the RES or by immunization with SAL cells exposed to x-rays, nitrogen mustard, iodoacetate or glutaraldehyde. However, immunization with SAL cells exposed to low doses of mitomycin-C slowed the growth of the challenge inoculum. Cells treated with high doses of mitomycin-C did not immunize. The results are interpreted in terms of rapid shedding of a tumour-specific antigen from the membrane of SAL cells.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000951:Antigens, Neoplasm; D001500:BCG Vaccine; D007114:Immunization; D007942:Leukemia, Experimental / Q000276:immunology*; D008466:Mechlorethamine / Q000494:pharmacology; D008937:Mitomycins / Q000494:pharmacology; D009163:Mycobacterium bovis / Q000276:immunology; D009368:Neoplasm Transplantation; D011425:Propionibacterium acnes / Q000276:immunology; D011830:Radiation Effects; D051381:Rats; D013154:Spleen / Q000276:immunology; D013997:Time Factors; D014185:Transplantation, Isogeneic
D000951:Antigens, Neoplasm; D001500:BCG Vaccine; D008937:Mitomycins; D008466:Mechlorethamine