title: The effects of adding adrenaline to etidocaine and lignocaine in extradural anaesthesia I: block characteristics and cardiovascular effects.
abstract: The addition of adrenaline 5 mug/ml, 1 : 200 000 to 1% etidocaine hydrochloride administered extradurally (L2-3) shortened significantly the onset time for sensory blockade, particularly with respect to the spread of the analgesia from the injection site, and shortened the already rapid onset of motor block. Etidocaine hydrochloride 1% plain caused a slower onset of block, laster longer and produced more profound analgesia over the caudal dermatomes than did 2% lignocaine hydrochloride. The motor block from plain etidocaine was more profound in its extent and lasted longer than that caused by lignocaine. With regard to cardiovascular variables, there were no significant differences between subjects receiving the plain etidocaine and the plain lignocaine. However, subjects receiving etidocaine with adrenaline exhibited increased cardiac stimulation and a decrease in total peripheral resistance over the first 150 min.
mesh_terms: D000083:Acetanilides / Q000031:analogs & derivatives; D000328:Adult; D000767:Anesthesia, Epidural; D002986:Clinical Trials as Topic; D004347:Drug Interactions; D004837:Epinephrine / Q000494:pharmacology*; D005041:Etidocaine / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008012:Lidocaine / Q000494:pharmacology; D008297:Male; D009407:Nerve Block; D013564:Sympathetic Nervous System / Q000187:drug effects; D013997:Time Factors
chemical_list: D000083:Acetanilides; D008012:Lidocaine; D005041:Etidocaine; D004837:Epinephrine