title: Androgen receptors and the molecular basis for the action of antiadrogens in the ventral prostate.
abstract: In the rat ventral prostate, various antiandrogens can interfere with the normal formation of an androgen-receptor complex which appears to be required for androgen action. Some of the antagonists may act by inhibiting the enzymatic formation of 5 alpha-dihydrotestosterone or by competing with androgens for the binding sites on the receptors, whereby interacting with and altering the receptor molecules themselves. If the action of an androgen-receptor complex can indeed occur at the stage of gene transcription as well as in certain post-transcriptional processes, the molecular site of antiandrogen action may be in the nuclei and/or cytoplasm of the target cells.
mesh_terms: D000726:Androgen Antagonists; D000818:Animals; D002352:Carrier Proteins / Q000032:analysis; D003272:Contraceptive Agents, Male / Q000494:pharmacology; D003534:Cyproterone / Q000494:pharmacology; D003600:Cytosol / Q000032:analysis; D013196:Dihydrotestosterone / Q000096:biosynthesis; D005485:Flutamide / Q000494:pharmacology; D005796:Genes; D008297:Male; D008968:Molecular Conformation; D011467:Prostate / Q000187:drug effects* / Q000502:physiology; D011485:Protein Binding / Q000187:drug effects; D012313:RNA / Q000096:biosynthesis; D051381:Rats; D011944:Receptors, Androgen / Q000187:drug effects*; D011987:Receptors, Steroid / Q000187:drug effects*; D014158:Transcription, Genetic
chemical_list: D000726:Androgen Antagonists; D002352:Carrier Proteins; D003272:Contraceptive Agents, Male; D011944:Receptors, Androgen; D011987:Receptors, Steroid; D013196:Dihydrotestosterone; D012313:RNA; D005485:Flutamide; D003534:Cyproterone