title: Effects of imipramine and methylphenidate on perceptual-motor performance of hyperactive children.
abstract: Perceptual-motor effects of imipramine and methylphenidate were evaluated in a double-blind study of 47 hyperactive children. No effects were found for imipramine, although methylphenidate improved performance on several tests. Improvement due to methylphenidate was not related to base-line scores. A discriminant function was computed to compare baseline perceptual-motor scores of the hyperactive and 41 normal children. Only half of the hyperactive children were clearly discriminated from normal children by the discriminant function. The digit-span test, which was not sensitive to methylphenidate, effectively discriminated hyperactive from normal children.
mesh_terms: D000293:Adolescent; D002648:Child; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D006948:Hyperkinesis / Q000188:drug therapy*; D007099:Imipramine / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008774:Methylphenidate / Q000494:pharmacology* / Q000627:therapeutic use; D009048:Motor Skills / Q000187:drug effects*; D010919:Placebos; D011581:Psychological Tests; D011930:Reaction Time / Q000187:drug effects; D014796:Visual Perception / Q000187:drug effects*; D014888:Wechsler Scales
chemical_list: D010919:Placebos; D008774:Methylphenidate; D007099:Imipramine