title: [Regulation of growth and lysine-synthesizing activity of the lysine producer, Brevibacterium SP 22 L., by the intensity of stirring of the medium].
abstract: The intensity of medium stirring at a constant pO2 influenced the specific rate of Brevibacterium sp. 22 L growth and lysine synthesis. During periodic cultivation the maximum specific rate of the culture growth can be achieved with a more intensive stirring than the maximum lysine synthesizing activity. At different intensities of medium stirring the lysins synthesizing activity was directly related to the activity of tricarboxylic acid cycle dehydrogenases. It is suggested that a decrease in the lysine synthesizing activity of the bacterial culture at a high intensity of medium stirring is connected with an inhibition or repression of tricarboxylic acid cycle enzymes.
mesh_terms: D001431:Bacteriological Techniques; D001951:Brevibacterium / Q000201:enzymology / Q000254:growth & development / Q000502:physiology*; D003470:Culture Media; D004247:DNA / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D007521:Isocitrate Dehydrogenase / Q000378:metabolism; D008239:Lysine / Q000096:biosynthesis; D008291:Malate Dehydrogenase / Q000378:metabolism; D012313:RNA / Q000378:metabolism; D013385:Succinate Dehydrogenase / Q000378:metabolism
chemical_list: D003470:Culture Media; D012313:RNA; D004247:DNA; D008291:Malate Dehydrogenase; D007521:Isocitrate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D013385:Succinate Dehydrogenase; D008239:Lysine
vernacular_title: Reguliatsiia rosta i lizinsinteziruiushcheĭ aktivnosti produtsenta lizina Brevibacterium SP 22 L. intensivnost'iu peremeshivaniia sredy