A mechanism of migration inhibition involving components of the coagulation system.
Lymph from pigs given bacillus Calmette-Guérin (BCG) and stimulated in the drainage area of a cannulated lymph node with tuberculin (PPD) had potent in vitro macrophage migration inhibitory activity. A similar observation has previously been made in sheep by other workers. In the sheep, part of, and in the pig, almost all of, this inhibitory activity was produced, not by a factor resembling the so-called 'migration inhibitory factor', but by a mechanism involving a protease and fibrinogen. It is suggested that exudate cells, having potent coagulation-promoting activity, can promote the deposition of fibrin about themselves, and thus 'trapped' are unable to migrate.
D000818:Animals; D001500:BCG Vaccine; D001777:Blood Coagulation; D002458:Cell Fractionation; D002464:Cell Migration Inhibition; D005337:Fibrin / Q000276:immunology / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D005455:Fluorescent Antibody Technique; D006493:Heparin / Q000494:pharmacology; D006358:Hot Temperature; D008196:Lymph / Q000276:immunology*; D008263:Macrophage Migration-Inhibitory Factors / Q000378:metabolism; D008264:Macrophages / Q000276:immunology*; D009163:Mycobacterium bovis; D012756:Sheep; D013300:Streptokinase / Q000494:pharmacology; D013552:Swine; D013925:Thromboplastin / Q000378:metabolism; D014361:Trypsin Inhibitors / Q000494:pharmacology; D014373:Tuberculin
D001500:BCG Vaccine; D008263:Macrophage Migration-Inhibitory Factors; D014361:Trypsin Inhibitors; D014373:Tuberculin; D005337:Fibrin; D005340:Fibrinogen; D006493:Heparin; D013925:Thromboplastin; D013300:Streptokinase