Studies on the destruction of adrenal and testicular cytochrome P-450 by spironolactone. Requirement for the 7alpha-thio group and evidence for the loss of the heme and apoproteins of cytochrome P-450.
D000311:Adrenal Glands / Q000187:drug effects / Q000201:enzymology*; D000818:Animals; D001051:Apoenzymes / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004285:Dogs; D006168:Guinea Pigs; D006418:Heme / Q000378:metabolism; D008297:Male; D008861:Microsomes / Q000187:drug effects / Q000201:enzymology; D051381:Rats; D013045:Species Specificity; D013148:Spironolactone / Q000031:analogs & derivatives / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013737:Testis / Q000187:drug effects / Q000201:enzymology*
D001051:Apoenzymes; D013148:Spironolactone; D006418:Heme; D003577:Cytochrome P-450 Enzyme System