Strain-dependent thermosensitivity influencing intracellular differentiation of Trypanosoma cruzi in cell culture.
Temperature strongly influenced morphogenesis of intracellular trypomastigotes in cell culture infected with 2 different strains of T. cruzi. With the Gilmar strain the amastigote-to-trypomastigote differentiation readily occurred at 33 and 37 C, whereas the CL strain differentiation took place at 33C but was inhibited at 37 C. The possiblity of this selective thermosensitivity resulting from mutational adaptation of the parasite is discussed.
D000818:Animals; D002454:Cell Differentiation; D002478:Cells, Cultured; D051379:Mice; D013696:Temperature; D014349:Trypanosoma cruzi / Q000166:cytology* / Q000254:growth & development