The effects of inhibitors of nucleic acid and protein synthesis on the replication of Spodoptera frugiperda nuclear polyhedrosis virus in cultured Spodoptera frugiperda cells.
The effects of inhibitors of nucleic acid and protein synthesis on the replication of Spodoptera frugiperda nuclear polyhedrosis virus have been determined. Two inhibitors of protein synthesis-cycloheximide and puromycin-were irreversible inhibitors of virus multiplication. Three inhibitors of nucleic acid synthesis-actinomycin D, cytosine arabinoside and camptothecin- prevented virus multiplication; only camptothecin was reversible. Rifampicin had no effect on virus multiplication.
D002166:Camptothecin / Q000494:pharmacology*; D002460:Cell Line; D003513:Cycloheximide / Q000494:pharmacology*; D003561:Cytarabine / Q000494:pharmacology*; D003609:Dactinomycin / Q000494:pharmacology*; D007304:Insect Viruses / Q000187:drug effects* / Q000254:growth & development; D007313:Insecta; D011691:Puromycin / Q000494:pharmacology*; D012293:Rifampin / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects*
D003561:Cytarabine; D003609:Dactinomycin; D011691:Puromycin; D003513:Cycloheximide; D012293:Rifampin; D002166:Camptothecin