Demonstration of cell-mediated immunological reactivity to transplantation antigens in uveo-retinal tissues.
Lymph node cells from inbred rats, sensitized against allotransplantation antigens, were tested for reactivity against uveo-retinal tissues, using a two-step leucocyte migration inhibition test: (1) These tissues induced positive reactions indicating the presence of transplantation antigens. (2) This was true for strong and weaker histoincompatibility systems. (3) Quantitatively, uveo-retinal tissues were somewhat less reactive than lymphocytes as antigen.
D000818:Animals; D002464:Cell Migration Inhibition; D006649:Histocompatibility Antigens; D007111:Immunity, Cellular; D008198:Lymph Nodes / Q000166:cytology; D051381:Rats; D011917:Rats, Inbred Lew; D011919:Rats, Inbred Strains; D012160:Retina / Q000276:immunology*; D016038:Skin Transplantation; D014181:Transplantation Immunology; D014184:Transplantation, Homologous; D014602:Uvea / Q000276:immunology*
D006649:Histocompatibility Antigens