Preliminary evaluation of alpha-adrenergic blocking agents in children with neurogenic bladder due to myelomeningocele.
Twenty children with myelomeningocele and neurogenic bladder dysfunction were treated with alpha-adrenergic blocking agents. The results were satisfactory and are considered to justify the use of these drugs, especially for children who have weak or absent detrusor activity and urethral outflow resistance not of the dyssynergic type. There are indications that urinary diversion in such cases may be able to be postponed when alpha-adrenergic blocking agents are used more routinely.
D001003:Anal Canal; D002648:Child; D002675:Child, Preschool; D004576:Electromyography; D005260:Female; D006801:Humans; D008297:Male; D008591:Meningomyelocele / Q000150:complications*; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D010643:Phenoxybenzamine / Q000627:therapeutic use*; D010646:Phentolamine / Q000627:therapeutic use*; D016135:Spinal Dysraphism / Q000150:complications*; D014521:Urethra; D001750:Urinary Bladder, Neurogenic / Q000188:drug therapy* / Q000209:etiology; D014567:Urography
D010643:Phenoxybenzamine; D010646:Phentolamine