[Studies of cellular sensitization to BCG and PPD using leukocyte cell migration inhibition].
Leucocyte inhibition migration test (LMT) with BCG and PPD was applied in pulmonary tuberculosis, lung cancer and sarcoidosis. No significant differences were noticed in the results obtained with each of the two antigenic materials; nevertheless, one case lobectomized of lung cancer successively treated with chemiotherapie and immunostimulation with BCG presented LMT positivity with BCG and negativity with PPD. The unpublished results of the former investigations carried out with brute tuberculin (LMT) on patients with pulmonary tuberculosis are here reported no significant difference was noticed between the results obtained with brute tuberculin, and the results with PPD. The still unsettled problem presented by the lack of inhibition in the presence of PPD in leucocyte migration test in patients with areactive (AA) and intermediate areactive (AI) tuberculosis is also briefly discussed. Finally, the existence of a dissociation between the cutaneous delayed test and the in vitro test for the detection of cellular sensibilisation is confirmed even when LMT is applied either in the presence of BCG or of PPD.
D000917:Antibody Formation; D001500:BCG Vaccine; D002464:Cell Migration Inhibition; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007111:Immunity, Cellular; D007962:Leukocytes / Q000276:immunology*; D008175:Lung Neoplasms / Q000276:immunology; D009163:Mycobacterium bovis / Q000276:immunology*; D012507:Sarcoidosis / Q000276:immunology; D014374:Tuberculin Test; D014397:Tuberculosis, Pulmonary / Q000276:immunology
D001500:BCG Vaccine
Rilievo della sensibilizzazione cellulare al BCG ed al PPD mediante il test di inibizione della migrazione leucocitaria