Mapping of trichodermin resistance in Saccharomyces cerevisiae: a genetic locus for a component of the 60S ribsomal subunit.
Resistance to the protein synthesis inhibitor trichodermin in Saccharomyces cerevisiae has been studied. A single recessive nuclear gene was responsible for resistance. The resistance locus, tcm1 was found to be closely linked (1 centi-morgan) to the locus pet 17 on the right arm of chromosome XV. The mutation to trichodermin resistance conferred resistance to other 12,13-epoxytrichothecenes and to the structurally unrelated antibiotic anisomycin.
D000841:Anisomycin / Q000494:pharmacology; D002875:Chromosomes; D004352:Drug Resistance, Microbial; D005808:Genes, Recessive; D008040:Genetic Linkage; D009154:Mutation; D012441:Saccharomyces cerevisiae / Q000187:drug effects*; D012717:Sesquiterpenes / Q000494:pharmacology*; D014243:Trichodermin / Q000494:pharmacology*
D012717:Sesquiterpenes; D014243:Trichodermin; D000841:Anisomycin