[Cytochrome P450. Its importance in toxicology. II. Regulation of its biosynthesis and its activity. Activation and inhibition].
The authors emphasize the influence of hormonal and nutritional factors on the activity level of microsomal enzymes. Induction process of hepatic cytochrome P450 and microsomal enzymes by xenobiotics are described. The existence of different types of hemoprotein P450 in response to the action of different inductors is discussed. We also propose some hypothesis concerning the action mechanism of inhibitors of microsomal enzymes and we point out the role of environmental pollutants.
D000818:Animals; D002245:Carbon Dioxide / Q000494:pharmacology; D002384:Catalysis; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis* / Q000378:metabolism; D004785:Environmental Pollutants / Q000494:pharmacology; D004790:Enzyme Induction / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005260:Female; D012739:Gonadal Steroid Hormones / Q000494:pharmacology; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology* / Q000378:metabolism; D051381:Rats
D004785:Environmental Pollutants; D004791:Enzyme Inhibitors; D012739:Gonadal Steroid Hormones; D002245:Carbon Dioxide; D003577:Cytochrome P-450 Enzyme System
Le cytochrome P450. Son intérêt en toxicologie. II. Régulation de sa biosynthèse et de son activité. Activation et inhibition