Abnormalities of bladder innervation in diabetes mellitus.
Electrophysiologic evaluation of the neural pathways involved in bladder and urethral function is described in 30 patients with diabetes mellitus. The study showed decreased conduction velocities in patients with the detrusor reflex as well as in detrusor areflexia. The findings indicated that diabetic vesical dysfunction is principally the result of segmental demyelination in the peripheral nerve supply to the detrusor muscle and urethra.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D003711:Demyelinating Diseases / Q000503:physiopathology; D048909:Diabetes Complications; D003929:Diabetic Neuropathies / Q000503:physiopathology*; D004576:Electromyography; D004594:Electrophysiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction; D009431:Neural Conduction; D010525:Peripheral Nerves / Q000503:physiopathology; D014521:Urethra / Q000294:innervation* / Q000503:physiopathology*; D001743:Urinary Bladder / Q000294:innervation* / Q000503:physiopathology; D001750:Urinary Bladder, Neurogenic / Q000503:physiopathology*; D014549:Urinary Incontinence / Q000150:complications