Blood-gas changes during induced hypotension with sodium nitroprusside.
A blood-gas study of the respiratory effects of sodium nitroprusside during anaesthesia has shown a marked reduction in PaO2 when the drug was administered. After nitroprusside PaO2 returned to the previous values. It is suggested that the reduction in PaO2 is a result of an increased scatter of ventilation/perfusion relationships in the lung. The reduction in PaO2 was evident during both spontaneous and artificial ventilation. Nitroprusside was associated with a small decrease in actual bicarbonate.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001639:Bicarbonates / Q000097:blood; D002986:Clinical Trials as Topic; D005260:Female; D005292:Ferricyanides / Q000494:pharmacology; D006801:Humans; D007023:Hypotension, Controlled; D008297:Male; D008875:Middle Aged; D009599:Nitroprusside / Q000494:pharmacology; D010100:Oxygen / Q000097:blood*; D014692:Ventilation-Perfusion Ratio / Q000187:drug effects
D001639:Bicarbonates; D005292:Ferricyanides; D009599:Nitroprusside; D010100:Oxygen