title: Malignant nephrosclerosis during pregnancy and in the postpartum period (the uremic hemolytic syndrome).
abstract: Histologic, immunohistologic, and ultrastructural features are presented of two cases with malignant nephrosclerosis during pregnancy. Primary malignant nephrosclerosis emerges as a clinical entity which can be distinguished from toxemia of pregnancy in the midtrimester and post partum. The first description of malignant nephrosclerosis dates from 40 years ago, but only a few cases were reported associated with pregnancy. Although disseminated intravascular coagulation seems involved, the morphology is different from that of toxemia. Malignant nephrosclerosis reveals a close similarity to the hemolytic uremic syndrome. Early diagnosis by renal biopsy and proper treatment may prevent a lethal outcome due to progressive failure.
mesh_terms: D000328:Adult; D002196:Capillaries / Q000648:ultrastructure; D005260:Female; D005455:Fluorescent Antibody Technique; D006463:Hemolytic-Uremic Syndrome / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007678:Kidney Glomerulus / Q000098:blood supply / Q000648:ultrastructure; D009400:Nephrosclerosis / Q000276:immunology / Q000473:pathology*; D011247:Pregnancy; D011248:Pregnancy Complications; D011644:Puerperal Disorders / Q000276:immunology / Q000473:pathology*