title: Antimalarials. 8. Synthesis of amino ethers as candidate antimalarials.
abstract: Based upon the antimalarial activities demonstrated by compounds I and II a series of amino ethers represented by structures III-VI was synthesized. These structures incorporated several modifications of compound II. The compounds prepared displayed no activity in either the Rane P. berghei mouse screen or the Rane P. gallinaceum sporozoite-induced chick test.
mesh_terms: D000588:Amines / Q000138:chemical synthesis / Q000627:therapeutic use; D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000627:therapeutic use; D002645:Chickens; D008288:Malaria / Q000188:drug therapy; D051379:Mice; D010962:Plasmodium berghei
chemical_list: D000588:Amines; D000962:Antimalarials