title: Induction by parathyroid hormone of ornithine decarboxylase in rabbit costal chondrocytes in culture.
abstract: The activity of ornithine decarboxylase (ODC) in rabbit costal chondrocytes in culture markedly increased after addition of parathyroid hormone (PTH), reaching a maximum 4 to 5 h after PTH addition. The effect of PTH was dose-dependent both in the presence and absence of fetal calf serum. Addition of cycloheximide or actinomycin D prevented the induction of ODC by PTH. Calcitonin, 1,25-dihydroxyvitamin D3, and vitamin A had no stimulatory effect on the activity of ODC, and did not inhibit the induction of ODC by PTH, when added with PTH.
mesh_terms: D000818:Animals; D002116:Calcitonin / Q000494:pharmacology; D002262:Carboxy-Lyases / Q000096:biosynthesis*; D002356:Cartilage / Q000187:drug effects / Q000378:metabolism*; D002478:Cells, Cultured; D003513:Cycloheximide / Q000494:pharmacology; D003609:Dactinomycin / Q000494:pharmacology; D004100:Dihydroxycholecalciferols / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004790:Enzyme Induction / Q000187:drug effects; D009955:Ornithine Decarboxylase / Q000096:biosynthesis*; D010281:Parathyroid Hormone / Q000494:pharmacology*; D011817:Rabbits
chemical_list: D004100:Dihydroxycholecalciferols; D010281:Parathyroid Hormone; D003609:Dactinomycin; D002116:Calcitonin; D003513:Cycloheximide; D002262:Carboxy-Lyases; D009955:Ornithine Decarboxylase