title: Efficacy of pralidoxime iodide and obidoxime dichloride as antidotes in diazinon-poisoned goslings.
abstract: The antidotal efficacy of pralidoxime iodide and obidoxime dichloride was investigated in goslings poisoned by a supralethal dose of the organophosphorus insecticide diazinon. Various doses of both drugs were administered by intramuscular injection when the poisoned birds were unable to walk. Pralidoxime at 100 mg/kg brought about a complete and speedy clinical recovery. Fifty mg/kg induced recovery in 4 of 6 poisoned goslings, and 25 mg/kg successfully trated only 1 of 6 birds. Obidoxime at 25 mg/kg showed no therapeutic properties whereas 50 and 100 mg/kg delayed the death of some birds by several hours. At 100 mg/kg, all goslings had transient signs of intoxication, which precluded the use of this compound as an antidote at higher doses. The mode of action of these antidotes in diazinon-poisoned goslings is discussed.
mesh_terms: D000818:Animals; D003976:Diazinon / Q000506:poisoning*; D005777:Geese; D007306:Insecticides / Q000506:poisoning*; D009768:Obidoxime Chloride / Q000008:administration & dosage / Q000627:therapeutic use*; D011201:Poultry Diseases / Q000139:chemically induced / Q000188:drug therapy*; D011220:Pralidoxime Compounds / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D007306:Insecticides; D011220:Pralidoxime Compounds; D009768:Obidoxime Chloride; D003976:Diazinon