[Multicentre-clinical trial of the novel corticosteroid diflucortolone valerate in the forms of cream, ointment and fatty ointment. Part II: Comparative study with several commercial preparations (author's transl)].
6alpha,9-Difluoro-11beta-hydroxy-16alpha-methyl-21-valeryloxy-1,4-pregnadiene-3,20-dione (diflucortolone valerate, Nerisona) in the forms of cream, ointment and fatty ointment was investigated against 5 commercial preparations with beta-methasone-17-valerate, fluocinonide, fluocinolone acetonide, flumetasone pivalate and desoximetasone in 15 simultaneously conducted and multicentre-clinical studies-all on double-blind contralateral studies-involving a total of 1923 patients. The Nerisona preparations proved to be highly effective-particularly in eczematous diseases- and comparable to the above-mentioned commercial preparations. Nerisona ointment was shown to be superior to flumetasone cream. The statistical reliability of such data is discussed.
D000287:Administration, Topical; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003872:Dermatitis / Q000188:drug therapy; D004485:Eczema / Q000188:drug therapy; D004655:Emulsions; D005938:Glucocorticoids; D006801:Humans; D009823:Ointment Bases; D011244:Pregnadienediols / Q000627:therapeutic use*; D011565:Psoriasis / Q000188:drug therapy; D012871:Skin Diseases / Q000188:drug therapy*; D013259:Steroids, Fluorinated / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D004655:Emulsions; D005938:Glucocorticoids; D009823:Ointment Bases; D011244:Pregnadienediols; D013259:Steroids, Fluorinated
Multizentrische klinische Prüfung des neuen Corticosteroids Diflucortolonvalerianat als Creme, Salbe und Fettsalbe. II: Vergleichende Untersuchungen mit verschiedenen Handelspräparaten