Aminoglutethimide medical adrenalectomy for advanced prostatic carcinoma.
Complete adrenal suppression with aminoglutethimide has been accomplished in 7 patients with progressive stage D carcinoma of the prostate who had become refractory to orchiectomy and the administration of exogenous estrogens. A favorable response was noted in 3 patients. These preliminary results indicate that this agent may be as useful as surgical adrenalectomy in the treatment of progressive prostatic carcinoma. A brief discussion of the pharmacology of this agent, its mode of administration and the side effects are presented.
D000230:Adenocarcinoma / Q000188:drug therapy*; D000311:Adrenal Glands / Q000187:drug effects*; D000368:Aged; D000616:Aminoglutethimide / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000188:drug therapy*
D000616:Aminoglutethimide