Nonspecific stimulation of a secondary ocular antibody response.
Rabbits injected intravitreally with bovine gamma globulin (BGG) into the right eyes were challenged 3 months later by an intravitreal injection of ovalbumin (OA) into the left eyes. The rabbits were killed 6, 7, and 9 days after challenge and the number of cells producing antibody to both OA and BGG were enumerated. The uveal tract cells of all left eyes produced anti-BGG even though no BGG had been injected into the left eyes. The uveal tract response to OA was less pronounced and typical of a primary response. High anti-BGG titers were found in the aqueous and vitreous humors of the left eyes of many of the rabbits. The reasons for this apparently non-specific stimulation of a secondary response in the absence of specific antigenic challenge are discussed.
D000818:Animals; D000917:Antibody Formation; D000918:Antibody Specificity; D000921:Antibody-Producing Cells / Q000276:immunology; D001082:Aqueous Humor / Q000276:immunology; D001500:BCG Vaccine; D002452:Cell Count; D005123:Eye / Q000276:immunology*; D006462:Hemolytic Plaque Technique; D008198:Lymph Nodes / Q000276:immunology; D009163:Mycobacterium bovis; D010047:Ovalbumin / Q000008:administration & dosage; D011817:Rabbits; D014602:Uvea / Q000276:immunology; D014822:Vitreous Body / Q000276:immunology
D001500:BCG Vaccine; D010047:Ovalbumin