The control of postoperative wound pain with the use of bupivacaine injections.
In a study of 50 operative cases 0.5% bupivacaine hydrochloride solution was injected in the area of the subcostal nerves at the time of closure of the wound except in 2 with previously noted infection. In the latter 2 cases the solution was injected when the wound was opened. No untoward results were noted from these injections and a definite decrease in the use of analgesics was required. In addition, there is preliminary evidence that peristalsis and flatus occur much earlier in cases in which the solution was used compared to a control group. Respiration was enhanced, earlier patient mobility was noted and the general depression from injectable analgesics was avoided.
D002045:Bupivacaine / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D005769:Gastrointestinal Motility / Q000187:drug effects; D006801:Humans; D007267:Injections; D007367:Intercostal Nerves / Q000187:drug effects; D007668:Kidney / Q000601:surgery; D008614:Meperidine / Q000627:therapeutic use; D009020:Morphine / Q000627:therapeutic use; D010149:Postoperative Pain / Q000188:drug therapy*; D014513:Ureter / Q000601:surgery; D001743:Urinary Bladder / Q000601:surgery
D009020:Morphine; D008614:Meperidine; D002045:Bupivacaine