[Theoretical and practical significance of the plaque formation intensification phenomenon in the presence of a specific antigen in experiments in vitro].
Experiments were conducted on 40 guinea pigs, 30 rats and 75 mice; a study was made of the presence and the mechanism of the phenomenon of intensification of plaque-formation under conditions of penicillin, ursol, horse serum, homologous intestine extract sensitization, or after hemostimulation on addition of a homologous antigen to preparations made by the modified Jerne's method. The presence of the phenomenon after the animal contact with penicillin, ursol, or hemo-stimulation, and its dependence on the interaction of the allergen with the immunocompetent cells were revealed.
D000485:Allergens / Q000494:pharmacology*; D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects*; D006168:Guinea Pigs; D006418:Heme / Q000494:pharmacology; D006462:Hemolytic Plaque Technique; D007106:Immune Sera / Q000494:pharmacology; D007422:Intestines; D051379:Mice; D010406:Penicillins / Q000494:pharmacology; D010655:Phenylenediamines / Q000494:pharmacology; D051381:Rats; D013154:Spleen / Q000276:immunology; D014020:Tissue Extracts / Q000494:pharmacology
D000485:Allergens; D007106:Immune Sera; D010406:Penicillins; D010655:Phenylenediamines; D014020:Tissue Extracts; D006418:Heme
Teoreticheskoe i prakticheskoe znachenie fenomena usileniia bliashkoobrazovaniia v prisutstvii spetsificheskogo antigena v opytakh in vitro