A regulatory locus for mouse beta-glucuronidase induction, Gur, controls messenger RNA activity.
A regulatory locus in a higher organism has been shown to control a specific messenger RNA activity. The Gur locus in mice regulates the production of kidney beta-glucuronidase messenger RNA activity after induction of the beta-glucuronidase structural gene, Gus, by testosterone. beta-Glucuronidase messenger RNA was assayed by its ability to direct the synthesis of catalytically active murine beta-glucuronidase in Xenopus oocytes.
D000818:Animals; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D005796:Genes; D005809:Genes, Regulator; D008040:Genetic Linkage; D005966:Glucuronidase / Q000235:genetics*; D006358:Hot Temperature; D007668:Kidney / Q000201:enzymology*; D051379:Mice; D009865:Oocytes / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics*; D013739:Testosterone / Q000494:pharmacology; D014981:Xenopus
D012333:RNA, Messenger; D013739:Testosterone; D005966:Glucuronidase