Cytochemical and cytoenzymatic investigations in the management of leukemias.
The value of certain cytochemical and cytoenzymatic investigations in the management of leukemias is discussed in different types of acute or chronic leukemias. Among the data resulting from cytochemical methods those related to cellular biochemical components such as DNA, RNA, glycogen and lipids are particularly noteworthy. The results of cytoenzymatic investigations have stressed the necessity of knowing the activity of certain enzymes such as peroxidases, alkaline and acid phosphatases, beta-glucuronidase, succinate dehydrogenase, lactate dehydrogenase and glucose-6-phosphate dehydrogenase a.o. The prospective value of enzymes such as dehydrofolate reductase, DNA and RNA polymerases, DNA and RNA-ases a.o. in the management of leukemias is also mentioned.
D000135:Acid Phosphatase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D002466:Cell Nucleolus / Q000378:metabolism; D004796:Clinical Enzyme Tests; D004247:DNA / Q000096:biosynthesis / Q000378:metabolism*; D005966:Glucuronidase / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism*; D006412:Hematopoietic Stem Cells / Q000378:metabolism; D006651:Histocytochemistry; D006801:Humans; D007938:Leukemia / Q000175:diagnosis* / Q000201:enzymology / Q000378:metabolism* / Q000628:therapy; D007945:Leukemia, Lymphoid / Q000378:metabolism; D015470:Leukemia, Myeloid, Acute / Q000378:metabolism; D050356:Lipid Metabolism; D010088:Oxidoreductases / Q000378:metabolism; D010503:Periodic Acid-Schiff Reaction; D010544:Peroxidases / Q000378:metabolism; D012313:RNA / Q000096:biosynthesis / Q000378:metabolism
D012313:RNA; D006003:Glycogen; D004247:DNA; D010088:Oxidoreductases; D010544:Peroxidases; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D005966:Glucuronidase