[The 32P-incorporation into nucleic acids and adenosine phosphates of the rat brain after acute and chronic influence of meclofenoxate (author's transl)].
Beta-Dimethylaminoethyl-p-chlorophenoxyacetate hydrochloride (meclofenoxate, Helfergin) was adminstered orally in dosages of 300 mg/kg 3 times during an 18-h period. The incorporation rate of the total and cytoplasmic RNA as well as of ATP, ADP and AMP decreased. Contradictory results were obtained after a 16-day treatment with orally 300 mg/kg per day: while the 32P-incorporation rate of the cytoplasmic RNA and the 3 adenosine phosphates increased, the nuclear RNA showed a correspondent diminishing. No changes of the ATP content could be observed in any group. The differences between the acute and chronic experiments could be explained by a different excitation of the animals and by the very different dosages. The increased 32P-incorporation into the cytoplasmic and into the adenosine phosphates in the chronic experiments are explained by a stimulation of the pentose phosphate shunt which yields mainly the phosphate group for the synthesis of AMP.
D000227:Adenine Nucleotides / Q000096:biosynthesis*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D002467:Cell Nucleus / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D005260:Female; D006016:Glycolates / Q000494:pharmacology*; D002504:Meclofenoxate / Q000494:pharmacology*; D010428:Pentosephosphates / Q000378:metabolism; D012313:RNA / Q000096:biosynthesis*; D051381:Rats
D000227:Adenine Nucleotides; D006016:Glycolates; D010428:Pentosephosphates; D012313:RNA; D002504:Meclofenoxate
32P-Einbau in Nukleinsäuren und Adenosinphosphate des Rattengehirns nach akuter und chronischer Einwirkung von Meclofenoxat