Kinetics of duodenal ulcer healing: effect of treatment with cimetidine.
In a double-blind trial, 12 in-patients with endoscopically proven duodenal ulceration were treated with cimetidine (0.8 g daily) or placebo. Ulcer sizes were assessed endoscopically before treatment and at weekly intervals during treatment. Duodenal-ulcer healing was significantly more rapid in patients on cimetidine than in those receiving the placebo (p less than 0.0005): half-times of ulcer healing were about 6 days (on cimetidine) as compared to about 20 days (on placebo). No untoward clinical or laboratory effects were observed.
D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004381:Duodenal Ulcer / Q000188:drug therapy*; D006146:Guanidines / Q000627:therapeutic use*; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use*; D008297:Male; D010919:Placebos; D012075:Remission, Spontaneous
D000897:Anti-Ulcer Agents; D006146:Guanidines; D007093:Imidazoles; D010919:Placebos