[Double-blind studies of the effect of ampicillin-cloxacillin (Rectocillin) on acute otorhinolaryngological infections (author's transl)].
Patients with acute otitis media, tonsillitis and upper respiratory tract infections were divided into 2 groups and treated with ampicillin-cloxacillin (Rectocillin) 1 g/day or ampicillin (AB-PC) 1 g/day, respectively. The therapeutic effect and side effect of these two drugs were studied comparatively by double blind tests. The effective rate in the Rectocillin group was 85.1%, and that in the AB-PC group was 86.7%. There was no significant difference in the therapeutic effect between two drugs. Ten cases in the Rectocillin group and 4 cases in the AB-PC group complained of disorders supposedly due to administration of these drugs. Such side effects in the former group were all gastrointestinal disorders, but in the latter, 2 cases of eruption, one case of headache and one case of gastrointestinal disorder.
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000667:Ampicillin / Q000008:administration & dosage* / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003023:Cloxacillin / Q000008:administration & dosage* / Q000627:therapeutic use; D004338:Drug Combinations / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010033:Otitis Media / Q000188:drug therapy; D010038:Otorhinolaryngologic Diseases / Q000188:drug therapy*; D012141:Respiratory Tract Infections / Q000188:drug therapy; D014069:Tonsillitis / Q000188:drug therapy
D004338:Drug Combinations; D000667:Ampicillin; D003023:Cloxacillin