Effect of cephalothin on growth patterns of micro-organisms.
Isolates of Staphylococcus aureus, Escherichia coli. Klebsiella pneumoniae and Proteus mirabilis were incubated in the presence of inhibitory concentrations of cephalothin. After destruction of the antibiotic, there was a lag phase before S. aureus began to proliferate again. When similar experiments were conducted with E. coli, K. pneumoniae, and P. mirabilis, no lag phase was observed. This data suggests that the inhibitory activity of cephalosporins may be different for gram-positive cocci and gram-negative bacilli.
D001419:Bacteria / Q000187:drug effects / Q000254:growth & development*; D002512:Cephalothin / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D007711:Klebsiella pneumoniae / Q000187:drug effects; D011513:Proteus mirabilis / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013997:Time Factors
D002512:Cephalothin