Comparison of natural and synthetic prostaglandins on gastric and pancreatic secretions and peptic ulcer formation in conscious cats.
In conscious cats with chronic gastric and pancreatic fistulas, the natural prostaglandins (PGs) of the E (PGE1 and PGE2) and F (PGF1 alpha and PGF2 alpha) series and synthetic 15-methyl analog of PGE2, 15(S) 15-methyl-PGE2 methylester were compared with regard to their action on gastric and pancreatic secretions and peptic ulcer formation. This study indicates that in comparison with natural PGs, the synthetic 15-methyl analog of PGE, is a more potent inhibitor of gastric secretion regardless of the route of administration and the mode of gastric stimulation.  It more effectively prevents the formation of peptic ulcers in conscious cats.
D000818:Animals; D002415:Cats; D003243:Consciousness; D005750:Gastric Juice / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology; D007275:Injections, Intravenous; D010189:Pancreatic Juice / Q000378:metabolism*; D010418:Pentagastrin / Q000494:pharmacology; D010434:Pepsin A / Q000378:metabolism; D010437:Peptic Ulcer / Q000139:chemically induced*; D011458:Prostaglandins E / Q000008:administration & dosage / Q000494:pharmacology*; D011460:Prostaglandins F / Q000008:administration & dosage / Q000494:pharmacology*; D012636:Secretory Rate / Q000187:drug effects
D011458:Prostaglandins E; D011460:Prostaglandins F; D006632:Histamine; D010434:Pepsin A; D010418:Pentagastrin