Serum lithium levels and long-term diuretic use.
In normal volunteers whose conditions were stablized with lithium carbonate, there were no significant changes in serum lithium levels during a two-week period while they received 40 mg/day of furosemide. During another two-week period, a 50 mg/day dosage of hydrochlorothiazide did cause a significant rise in serum lithium levels. These observations suggest that a substantial amount of lithium and a loop diuretic may not require modification of the lithium dosage.
D000328:Adult; D004347:Drug Interactions; D005260:Female; D005665:Furosemide / Q000494:pharmacology*; D006801:Humans; D006852:Hydrochlorothiazide / Q000494:pharmacology*; D006973:Hypertension / Q000188:drug therapy; D007684:Kidney Tubules / Q000378:metabolism*; D008094:Lithium / Q000097:blood* / Q000378:metabolism / Q000494:pharmacology; D008138:Loop of Henle / Q000378:metabolism*; D008297:Male; D001523:Mental Disorders / Q000188:drug therapy
D006852:Hydrochlorothiazide; D005665:Furosemide; D008094:Lithium