title: Effect of active metabolites of chlordiazepoxide and diazepam, alone or in combination with alcohol, on psychomotor skills related to driving.
abstract: The interaction of the main metabolites of diazepam and chlordiazepoxide with alcohol was measured in two double-blind crossover subacute experiments on 40 healthy young volunteers. The drugs were administered for 2 weeks each. The variables measured were choice reaction time and accuracy, eye-hand coordination, divided attention, flicker fusion, proprioception, and nystagmus. ChL, MO and O significantly enhanced the alcohol-induced impairment of psychomotor skills whereas DMD did so only exceptionally on some subjects in the choice reaction test. It is concluded that the diazepam-alcohol interaction on psychomotor skills is mainly due to the parent compound. No correlations between the serum levels of the agents and the changes of performance were found.
mesh_terms: D000328:Adult; D000435:Alcoholic Intoxication; D001288:Attention / Q000187:drug effects; D001334:Automobile Driving; D002707:Chlordiazepoxide / Q000097:blood / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D003975:Diazepam / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology*; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D009048:Motor Skills / Q000187:drug effects*; D010076:Oxazepam / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology*; D010919:Placebos; D011930:Reaction Time / Q000187:drug effects*
chemical_list: D010919:Placebos; D000431:Ethanol; D010076:Oxazepam; D002707:Chlordiazepoxide; D003975:Diazepam