Lymphocyte subpopulations in uremics and in transplanted patients.
In 30 chronically uremics, 37 renal transplanted patients and 31 controls, the number of T- and B-cells was calculated as well as the lymphocyte response to the mitogens PHA, Con A and anti-B2m. In uremics the relative number of T-cells was normal, the number of B-cells was reduced and the response to mitogens was suppressed. During the early post transplantation period the relative number of both T- and B-cells was reduced as well as the mitogenic response. Following three months of successful transplantation the relative counts of T-cells and the response to mitogens returned to normal. The relative number of B-cells remained lowered however.
D001402:B-Lymphocytes / Q000276:immunology; D002908:Chronic Disease; D003208:Concanavalin A / Q000494:pharmacology; D006801:Humans; D016030:Kidney Transplantation; D037102:Lectins / Q000494:pharmacology; D007958:Leukocyte Count; D008213:Lymphocyte Activation / Q000187:drug effects; D013601:T-Lymphocytes / Q000276:immunology; D014184:Transplantation, Homologous; D014511:Uremia / Q000097:blood* / Q000276:immunology / Q000601:surgery
D037102:Lectins; D003208:Concanavalin A