Adjuvant and antitumor activities of Nocardia cell-wall skeletons.
The adjuvant activity of the cell-wall skeletons prepared from eight species (ten strains) of Nocardia was determined by Brunner's method using allogeneic cell-mediated cytotoxicity test. The antitumor activity of the cell-wall skeleton of N. rubra, which showed the most potent adjuvant activity, was examined using EL-4 leukemia and MH-134 hepatoma cells in syngeneic mice. Its results suggest that the cell-wall skeleton of N. rubra is more potent than BCG cell-wall skeleton as the immunotherapeutic agent for cancer immunotherapy in man. The chemical properties of the cell-wall skeleton of N. rubra were also described.
D000276:Adjuvants, Immunologic; D000818:Animals; D001500:BCG Vaccine; D002473:Cell Wall / Q000032:analysis / Q000276:immunology; D003601:Cytotoxicity Tests, Immunologic; D007111:Immunity, Cellular; D007167:Immunotherapy; D051379:Mice; D008815:Mice, Inbred Strains; D009163:Mycobacterium bovis / Q000276:immunology; D009374:Neoplasms, Experimental / Q000628:therapy*; D009615:Nocardia / Q000276:immunology* / Q000648:ultrastructure; D009821:Oils; D013154:Spleen / Q000276:immunology
D000276:Adjuvants, Immunologic; D001500:BCG Vaccine; D009821:Oils