title: Radionuclide evaluation of pulmonary function following hemithorax irradiation of normal dogs with 60Co or fast neutrons.
abstract: To assess the effects of therapeutic doses of radiation on regional pulmonary function, 28 dogs had serial chest radiographs and quantitative ventilation, perfusion, and aerosol studies at three-, six-, nine-, and twelve-month intervals after hemithorax irradiation with 60-Co-gamma photons or 15-MeV fast neutrons. Findings showed marked reductions in perfusion and aerosol deposition in the irradiated lungs of dogs in the high-dose photon and neutron groups and in the medium-dose neutron group. The effects of large photon and small neutron doses were similar (neutron RBE = 4.5). Radionuclide studies were found to be useful for detecting these alterations.
mesh_terms: D000818:Animals; D003037:Cobalt Radioisotopes; D004285:Dogs; D005214:Fast Neutrons; D005720:Gamma Rays; D008168:Lung / Q000000981:diagnostic imaging / Q000528:radiation effects*; D008170:Lung Compliance / Q000528:radiation effects; D008176:Lung Volume Measurements; D008297:Male; D011829:Radiation Dosage; D011859:Radiography; D011877:Radionuclide Imaging; D012062:Relative Biological Effectiveness; D012119:Respiration / Q000528:radiation effects*; D013147:Spirometry; D013667:Technetium; D014692:Ventilation-Perfusion Ratio / Q000528:radiation effects; D014980:Xenon Radioisotopes
chemical_list: D003037:Cobalt Radioisotopes; D014980:Xenon Radioisotopes; D013667:Technetium