[Controlled clinical research on the potassium-retaining action of various diuretic drugs].
The potassium-retaining action was evaluated in its kaliemic reflexes, in two diuretic associations composed respectively of hydrochlorothiazide + spironolactone and hydrochlorothiazide + amiloride. The potassium intraerythrocytic levels were also determined as well as the natriuresis, the natremia and the daily diuresis. Researches carried out on a group of patients affected by congestive heart failure showed that, the diuretic efficacy being equal, the association of hydrochlorothiazide + spironolactone does not significantly interfere, at the various posologic levels, with the potassium balance. On the contrary, in this regard, the associaiton of amiloride + hydrochlorothiazide appeared to be less manageable because therapeutic dosages showed a tendency to hyperdaliemia.
D000584:Amiloride / Q000009:adverse effects; D002986:Clinical Trials as Topic; D004231:Diuresis / Q000187:drug effects; D004232:Diuretics / Q000009:adverse effects*; D006801:Humans; D006852:Hydrochlorothiazide / Q000009:adverse effects; D006947:Hyperkalemia / Q000139:chemically induced; D011188:Potassium / Q000378:metabolism*; D013148:Spironolactone / Q000009:adverse effects
D004232:Diuretics; D006852:Hydrochlorothiazide; D013148:Spironolactone; D000584:Amiloride; D011188:Potassium
Ricerche cliniche controllate sull'effetto potassio-ritentivo di alcuni diuretici