title: [Action of acebutolol on heart rate and FEV1 in asthmatic patients. Single intravenous administration and long term oral administration].
abstract: In 7 asthmatic patients, intravenous injection of acebutolol resulted in a slowing of the heart rate by blocking the cardiac beta-receptors. An aerosol of isoprenaline, which accelerated the heart, is without effect after intravenous injection of acebutolol. On the contrary, isoprenaline caused similar changes in the FEV1 before and after acebutolol injection in the same patients. This effect confirms the slight action of the compound on the beta2-adrenergic receptors. Prolonged oral administration did not cause any adverse clinical effects in 6 asthmatic patients.
mesh_terms: D000070:Acebutolol / Q000008:administration & dosage / Q000494:pharmacology*; D000284:Administration, Oral; D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D005260:Female; D005540:Forced Expiratory Flow Rates; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007275:Injections, Intravenous; D007545:Isoproterenol / Q000037:antagonists & inhibitors; D008297:Male; D008448:Maximal Expiratory Flow Rate; D008875:Middle Aged
chemical_list: D000070:Acebutolol; D007545:Isoproterenol
vernacular_title: Action de l'acébutolol sur la fréquence cardiaque et le V.E.M.S. chez l'asthmatique. Injection intraveineuse unique et administration buccale prolongée