Double-blind clinical trial of 5-hydroxytryptophan in a case of Lesch-Nyhan syndrome.
5-Hydroxytryptophan (5-HTP) treatment of a single case of Lesch-Nyhan syndrome showing compulsive self-mutilation, athetoid movements, and characteristic clinical biochemical picture was studied on a double-blind basis. 5-HTP or placebo was administered for seven fortnightly treatment blocks. 5-HTP produced a significant reduction of athetoid movement and a sedative effect but did not improve the patient's mood or reduce self-mutilation.
D006916:5-Hydroxytryptophan / Q000097:blood / Q000627:therapeutic use*; D002648:Child; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D004644:Emotions / Q000187:drug effects; D006801:Humans; D007926:Lesch-Nyhan Syndrome / Q000188:drug therapy*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D012652:Self Mutilation / Q000188:drug therapy
D006916:5-Hydroxytryptophan