Massive resection and allograft transplantation in the treatment of malignant bone tumors.
Nineteen massive resections and allograft transplantations have been performed for malignant or aggressive bone tumors. Allograft procurment technic uses freezing of the segment to decrease immunogenicity of the bony portion and glycinerization of the cartilage to maintain chondrocyte viability during freezing and thawing. Fifteen Fifteen of the patients have been followed for an average of almost two years and were evaluated for early results by serial follow-up studies, including clinical, laboratoy, x-ray and scan data. Despite numerous complications (related to both tumor and operation) none have metastases, local recurrence, or major functional impairment except for two whose grafts became infected. We conclude that, although still experimental, allograft replacement may in the future serve as an important approach to certain neoplastic conditions of bones and joints.
D000230:Adenocarcinoma / Q000601:surgery; D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000601:surgery*; D016025:Bone Transplantation; D002102:Cadaver; D002358:Cartilage, Articular / Q000637:transplantation; D002813:Chondrosarcoma / Q000601:surgery; D005260:Female; D005266:Femoral Neoplasms / Q000601:surgery; D005354:Fibrosarcoma / Q000601:surgery; D005500:Follow-Up Studies; D005870:Giant Cell Tumors / Q000601:surgery; D005990:Glycerol / Q000008:administration & dosage; D006801:Humans; D008022:Ligaments / Q000637:transplantation; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D013530:Surgical Wound Infection; D013710:Tendons / Q000637:transplantation; D013977:Tibia; D013997:Time Factors; D014021:Tissue Preservation / Q000379:methods; D014184:Transplantation, Homologous
D005990:Glycerol