Effect of heparin on the priming with a protein antigen in mice.
Heparin has been found to stimulate or suppress the priming activity of a protein antigen (cock muscle phosphorylase-b) in mice depending on the various parameters (the dose of antigen, timing of administration, etc.). The adjuvant effect of endotoxin on priming was potentiated by a single dose of heparin injected 10-12 hours after immunization. Optimal doses of heparin incorporated into Freund's incomplete adjuvant also enhanced the humoral immune response first of all the development of 7 S immunologic memory. The possible mechanisms are discussed.
D000276:Adjuvants, Immunologic; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D000941:Antigens; D004731:Endotoxins; D004926:Escherichia coli; D005260:Female; D005620:Freund's Adjuvant; D006493:Heparin / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D006005:Phosphorylases / Q000276:immunology*
D000276:Adjuvants, Immunologic; D000941:Antigens; D004731:Endotoxins; D006493:Heparin; D005620:Freund's Adjuvant; D006005:Phosphorylases