title: Yeast mutants resistant to basic fuchsin: a genetic approach to the integration of nuclear and mitochondrial information.
abstract: In yeast, basic fuchsin both inhibits mitochondrial functions and is a potent mutagen for the mitochondrial genome. A genetic analysis of two mutants resistant to the dye indicate that: (1) resistance is specified by a nuclear gene; (2) the onset of resistance in sensitive cells is controlled by the mitochondrial genome; and (3) sensitive mitochondrial structures can be carried over for many cell generations in the presence of a resistant nuclear genotype.
mesh_terms: D003433:Crosses, Genetic; D004247:DNA; D004272:DNA, Mitochondrial; D004171:Diploidy; D004352:Drug Resistance, Microbial; D005111:Extrachromosomal Inheritance; D005796:Genes; D005838:Genotype; D009154:Mutation; D010641:Phenotype; D012394:Rosaniline Dyes / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects*
chemical_list: D004272:DNA, Mitochondrial; D012394:Rosaniline Dyes; D004247:DNA