title: Amantadine versus trihexyphenidyl in the treatment of neuroleptic-induced parkinsonism.
abstract: Amantadine is a putative dopaminergic compound known to be therapeutically effective in idiopathic and postencephalitic Parkinson's disease. In a double-blind placebo-controlled crossover study of 39 psychiatric inpatients, amantadine and trihexyphenidyl were equally effective in treating drug-induced parkinsonism, and amantadine produced fewer and less severe side effects. The authors suggest that amantadine is an effective alternative to atropine-like agents, with fewer implications for long-term risk of tardive dyskinesia.
mesh_terms: D000547:Amantadine / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D006801:Humans; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000188:drug therapy*; D014149:Tranquilizing Agents / Q000009:adverse effects*; D014282:Trihexyphenidyl / Q000627:therapeutic use*
chemical_list: D014149:Tranquilizing Agents; D014282:Trihexyphenidyl; D000547:Amantadine