Realization of genetic information programming the synthesis of pepsinogen-pepsin in the mucous membrane and tumors of the stomach in man.
Up to 19--20 fractions of separate RNA species and groups have been revealed in malignant tumors of the stomach and mucous membrane of patients with stomach cancer, ulcer and polyposis of the stomach by means of the method of analytical and preparative electrophoresis in 2.5% polyacrylamide gel. A more intensive incorporation of 14C uridine both into the nuclear and separate fractions of cytoplasmic RNA was observed in stomach tumors in comparison with the stomach mucous membrane of man. Pepsinogen-pepsin was synthesized by bound polysoms of the stomach mucous membrane. In stomach malignant tumors of man the polysomes were not capable of synthesizing this enzyme. Fractions of messenger RNA with sedimentation constants 16S-17S, possessing the ability to stimulate pepsinogen-pepsin synthesis in vitro, have been isolated from cytoplasmic RNA of a pig stomach mucous membrane.
D000818:Animals; D005753:Gastric Mucosa / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D010434:Pepsin A / Q000096:biosynthesis*; D010435:Pepsinogens / Q000096:biosynthesis*; D011132:Polyribosomes / Q000378:metabolism; D012313:RNA / Q000032:analysis / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D011817:Rabbits; D013274:Stomach Neoplasms / Q000378:metabolism*; D013276:Stomach Ulcer / Q000378:metabolism; D013552:Swine
D010435:Pepsinogens; D012333:RNA, Messenger; D012313:RNA; D010434:Pepsin A