Diagnosis of Hirschsprung's disease by punch biopsy of rectum.
234 punch biopsy specimens of rectal tissue were taken from 112 children. In 94% of the patients the diagnosis of Hirschsprung's disease was confirmed or refuted by the first biopsy. There were no false-positive or false-negative results. One patient developed a serious complication, a pelvic haematoma.
D000768:Anesthesia, General; D001706:Biopsy / Q000009:adverse effects / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D006406:Hematoma / Q000209:etiology; D006652:Histological Techniques; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008531:Megacolon / Q000175:diagnosis*; D010388:Pelvis; D012007:Rectum / Q000473:pathology*