Tissue specific regulation of prostaglandin production: stimulation of 6-ketoprostaglandin F1alpha biosynthesis by rat kidney cytosol.
Boiled cytosol of various rat tissues each affected prostaglandin biosynthesis by bovine seminal vesicle microsomes in a specific way. Kidney cytosol enhanced 6-ketoprostaglandin F1alpha production in a dose-dependent manner. This stimulatory effect was lost after dialysis. Liver, spleen and carrageenin granuloma cytosol inhibited 6-ketoprostaglandin F1alpha production but enhanced prostaglandin E2 production.
D000818:Animals; D003600:Cytosol / Q000378:metabolism; D006099:Granuloma / Q000378:metabolism; D066298:In Vitro Techniques; D007668:Kidney / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D008861:Microsomes / Q000378:metabolism; D009928:Organ Specificity; D011458:Prostaglandins E / Q000096:biosynthesis; D011460:Prostaglandins F / Q000096:biosynthesis*; D051381:Rats; D012669:Seminal Vesicles / Q000378:metabolism; D013154:Spleen / Q000378:metabolism
D011458:Prostaglandins E; D011460:Prostaglandins F