[Chemotherapy of inoperable endothoracic tumours (results of the Karrer and aco polycytostatic therapy) (author's transl)].
The success of chemotherapy of inoperable endothoracic cancer largely depends on interdisciplinary cooperation. 30 years of research have succeeded in developing some promising combinations of cytostatic agents. Administered sequentially they are better tolerated and this has made outpatient treatment possible. 87 persons had polycytostatic therapy according to the Karrer/Sighart formula. It was followed by a difinite improvement in the general condition of the patients, but without any substantial lengthening of the average survival time. The ACO scheme (Seeber/Schmidt) has been used since April 1977 in 42 persons. Preliminary results indicate a definite prologation of survival time, especially in cases of small-cell bronchogenic carcinoma.
D000328:Adult; D000368:Aged; D001984:Bronchial Neoplasms / Q000188:drug therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011736:Pyridoxine / Q000627:therapeutic use; D013899:Thoracic Neoplasms / Q000188:drug therapy*; D014748:Vinca Alkaloids / Q000627:therapeutic use; D014805:Vitamin B 12 / Q000627:therapeutic use
D014748:Vinca Alkaloids; D003520:Cyclophosphamide; D011736:Pyridoxine; D014805:Vitamin B 12; D005472:Fluorouracil; D008727:Methotrexate
Problematik der Chemotherapie inoperabler endothorakaler Tumoren--Erfahrungen und Ergebnisse mit zwei verschiedenen polyzytostatischen Schemata (Karrer und ACO) aus den Jahren 1971--1977 am Krankenhaus Grosshansdorf.