Exogenous estrogens and endometrial cancer.
Reports in the lay press that exogenous estrogens cause endometrial cancer are unjustified with the present evidence. The epidemiologic method used to identify retrospectively an increased association of estrogens with endometrial cancer cannot prove causality. Mortality from endometrial carcinoma has not increased in this country and may actually be starting to decline.
D001943:Breast Neoplasms / Q000188:drug therapy; D002369:Castration; D002979:Climacteric / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004967:Estrogens / Q000008:administration & dosage / Q000009:adverse effects* / Q000378:metabolism; D005260:Female; D006801:Humans; D007006:Hypogonadism / Q000188:drug therapy; D010024:Osteoporosis / Q000188:drug therapy; D011643:Publishing; D012189:Retrospective Studies; D012306:Risk; D012636:Secretory Rate; D014592:Uterine Hemorrhage / Q000188:drug therapy; D014594:Uterine Neoplasms / Q000139:chemically induced* / Q000209:etiology / Q000401:mortality
D004967:Estrogens