A convenient and rapid bioassay for inhibin.
A bioassay for inhibin, based on a dose-dependent suppression of HCG-induced ovarian weight increase in intact, immature female rats, is described. The method is specific and has acceptable sensitivity and precision such that it lends itself to statistically valid quantitative assay of inhibin activity. Being a 24-hour assay, it is conveniently and rapid performed as well as being a multiple bioassay for estimating potencies of various preparations.
D000818:Animals; D001681:Biological Assay; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism / Q000494:pharmacology; D007987:Gonadotropin-Releasing Hormone / Q000032:analysis; D009929:Organ Size / Q000187:drug effects; D010053:Ovary / Q000033:anatomy & histology; D051381:Rats; D012661:Semen / Q000032:analysis; D013735:Testicular Hormones / Q000032:analysis*
D006063:Chorionic Gonadotropin; D013735:Testicular Hormones; D007987:Gonadotropin-Releasing Hormone; D005640:Follicle Stimulating Hormone