Histochemical changes in the blood cells of schizophrenic patients under pimozide treatment.
Chromatin structure and nucleohistone pattern were investigated histochemically in the neutrophils of 11 schizophrenics and 16 healthy controls. Compared to controls, all schizophrenic parents prior to medication showed a distinctly different histochemical pattern consisting of increased concentration and abnormal distribution of nucleohistones. This pattern has been attributed to an increase of arginine-rich histones in schizophrenics. Pimozide administration exerted a normalizing effect on the nucleohistone distribution pattern. These findings further support our view that genomic expression abnormalities may be related to schizophrenic illness.
D000293:Adolescent; D000328:Adult; D001120:Arginine / Q000378:metabolism; D002843:Chromatin / Q000648:ultrastructure; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D005260:Female; D006651:Histocytochemistry; D006657:Histones / Q000097:blood / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism; D010868:Pimozide / Q000627:therapeutic use*; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D012562:Schizophrenia, Disorganized / Q000097:blood; D012563:Schizophrenia, Paranoid / Q000097:blood
D002843:Chromatin; D006657:Histones; D010868:Pimozide; D001120:Arginine