Excretion of metabolites of biogenic amines in patients with irradiated brain tumours.
The metabolities of biogenic amines were determined in the 24-hour urine samples of patients submitted to surgical removal of a malignant brain tumour and subsequently to telecobalt therapy of the corresponding head region. A significant increase in the excretion of 5-hydroxyindoleacetic acid (5-HIAA), vanillinmandelic acid (VMA) as well as of free 3-methoxy-4-hydroxy-phenylglycol (MHPG) during the period of irradiation was found. This increase is presumably the result of radiation induced release of their parent amines from the brain; in the case of VMA the secondary response of the peripheral sympathetic system might occur.
D000236:Adenoma / Q000652:urine; D000293:Adolescent; D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000532:radiotherapy / Q000652:urine*; D002528:Cerebellar Neoplasms / Q000652:urine; D002648:Child; D003404:Creatinine / Q000652:urine; D005260:Female; D005910:Glioma / Q000652:urine; D006018:Glycols / Q000652:urine*; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000652:urine*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000652:urine; D008297:Male; D008527:Medulloblastoma / Q000652:urine; D008734:Methoxyhydroxyphenylglycol / Q000652:urine*; D008875:Middle Aged; D009837:Oligodendroglioma / Q000652:urine; D010911:Pituitary Neoplasms / Q000652:urine; D012509:Sarcoma / Q000652:urine; D014642:Vanilmandelic Acid / Q000652:urine*
D006018:Glycols; D008734:Methoxyhydroxyphenylglycol; D006897:Hydroxyindoleacetic Acid; D014642:Vanilmandelic Acid; D003404:Creatinine