[Directed migration and differentiation of the neuroblasts in a mouse embryo spinal cord organ culture].
During maintaining of the transverse spinal cord sections from 12-14 day mouse embryo in the Maximov chambers differentiation of neuroglia cells and formation of organotypic structures of the explant took place. In a number of cases at 3-4 weeks of cultivation migration of bipolar neuroblast groups beyond the borders of the explant was observed, it was directed along the bundles of the nerve fibers--axons of mature neurons located in the central fragment of the cultivated tissue. The data obtained have shown that the nerve fibres growing from the explant may serve as conductors of migrating neuroblasts and induce their further differentiation. It has been suggested that in the developing spinal cord similar processes o neuroblasts migration along the tracts formed by the axons and their further  differentiation at the end points of such tracts may take place.
D000818:Animals; D001369:Axons / Q000648:ultrastructure; D002454:Cell Differentiation; D002465:Cell Movement; D003584:Cytological Techniques; D004622:Embryo, Mammalian / Q000166:cytology; D051379:Mice; D009412:Nerve Fibers / Q000166:cytology; D009457:Neuroglia / Q000166:cytology; D009474:Neurons / Q000166:cytology*; D009924:Organ Culture Techniques; D013116:Spinal Cord / Q000166:cytology*
Napravlennaia migratsiia i differentsirovka neĭroblastov v organnoĭ kul'ture spinnogo mozga myshinykh émbrionov