Tissue iso-renins.
1. Several extrarenal tissues contain enzymes which are similar to kidney renin: they hydrolyse angiotensinogen to form angiotensin I; they have characteristic substrate specificity; the physicochemical properties of kidney renin and of extrarenal tissue iso-renin are similar. 2. Results indicate that tissue iso-renins are part of a complex enzyme system with mainly local function. A possible biological role has been demonstrated in brain, adrenal gland and tissue culture.
D000311:Adrenal Glands / Q000032:analysis; D000804:Angiotensin II / Q000032:analysis; D000818:Animals; D001923:Brain Chemistry; D002831:Choroid Plexus / Q000032:analysis; D009369:Neoplasms / Q000032:analysis; D051381:Rats; D012083:Renin / Q000032:analysis / Q000134:cerebrospinal fluid
D000804:Angiotensin II; D012083:Renin