title: Recipient selection for renal retransplantation.
abstract: Analysis of over 1,000 kidney retransplants revealed an important effect of first graft duration and presensitization on graft outcome. Second cadaver donor grafts into patients without preformed cytotoxic antibodies and a first graft duration of more than 12 months survived at a high 1-year rate of 71 +/- 6%, in contrast to 29 +/- 6% in those whose first graft had failed in 1-3 months (P is less than 0.0001). Third or fourth transplants into patients with preformed cytotoxins survived at the poor rate of 17 +/- 6% at 1 year. To repeat all HLA mismatches from the first graft was found to result in decreased second graft survival.
mesh_terms: D002102:Cadaver; D002874:Chromosome Mapping; D003601:Cytotoxicity Tests, Immunologic; D006084:Graft Rejection; D006650:Histocompatibility Testing; D006801:Humans; D016030:Kidney Transplantation; D008233:Lymphotoxin-alpha / Q000032:analysis; D013997:Time Factors; D014184:Transplantation, Homologous
chemical_list: D008233:Lymphotoxin-alpha