Evaluation of carrageenan as an immunosuppressive agent and mediator of intravascular coagulation.
Carrageenan suppressed antibody responses to SRBC in mice and rats, measured in terms of splenic IgM PFC production. The effect, in mice, was dependent on dose and on the temporal relationship between treatment and antigen administration. Carrageenan was found to alter the time course of the PFC response and also to produce disseminated intravascular coagulation. Some correlation between the observed effects and the use of chemically distinct carrageenans was found. The possible mode of action of carrageenan is discussed in the light of these, and other findings.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D000921:Antibody-Producing Cells / Q000187:drug effects; D002351:Carrageenan / Q000494:pharmacology*; D003864:Depression, Chemical; D004211:Disseminated Intravascular Coagulation / Q000139:chemically induced*; D004431:Ear, External / Q000098:blood supply; D005337:Fibrin / Q000032:analysis; D006462:Hemolytic Plaque Technique; D007166:Immunosuppressive Agents / Q000494:pharmacology; D007511:Ischemia / Q000139:chemically induced; D008099:Liver / Q000473:pathology; D008297:Male; D051379:Mice; D008833:Microcirculation / Q000473:pathology; D051381:Rats; D013329:Structure-Activity Relationship; D013623:Tail / Q000098:blood supply; D013997:Time Factors
D007166:Immunosuppressive Agents; D002351:Carrageenan; D005337:Fibrin