title: Respiratory sinus arrhythmia in man: relation to cardiovascular pressures.
abstract: The relationship of repiratory sinus arrhythmia (RSA) to the accompanying oscillations of cardiovascular pressures has been studied in five healthy subjects. Tidal volumes (VT) of 1.0, 1.5, and 2.0 1 at a breathing rate of 6 c-min(-1) were used as reference. With identical VT, oesophageal pressure was varied by negative inspiratory pressure (NIP) and intermittent positive-pressure ventilation (IPPV). Compared with control, NIP with 1.01 significantly increased RSA, the oscillations of brachial artery pressures (PBA), and the net filling pressures of the ventricles. IPPV did not significantly change the variations of PBA but reduced RSA and the repiratory variations of the right ventricular end-diastolic net pressure. During control breathing and with NIP the acceleration of heart rate during inspiration was associated with rising PBA and rising net filling pressures of both ventricles. The results indicate that RSA may be elicited by cardiovascular reflexes due to changes in venous filling of the heart rather than by the variations in systemic arterial pressure.
mesh_terms: D000328:Adult; D001146:Arrhythmia, Sinus / Q000503:physiopathology*; D001794:Blood Pressure; D002245:Carbon Dioxide / Q000097:blood; D004947:Esophagus / Q000503:physiopathology; D006321:Heart / Q000503:physiopathology*; D006339:Heart Rate; D006801:Humans; D007384:Intermittent Positive-Pressure Breathing; D010313:Partial Pressure; D011175:Positive-Pressure Respiration; D011312:Pressure; D011651:Pulmonary Artery / Q000503:physiopathology; D012119:Respiration; D013990:Tidal Volume
chemical_list: D002245:Carbon Dioxide