title: Mutagenicity of volatile anesthetics: halothane.
abstract: The mutagenicity of halothane was tested in an in-vitro microbial assay system employing two histidine-dependent mutants of Salmonella typhimurium, TA98 and TA100, Halothane in concentrations ranging from 0.1 to 30 per cent was incubated with bacteria in the presence or absence of a metabolic activation system prepared from either rat liver treated with Aroclor 1254 or human liver. Trifluoroacetic acid, a major metabolite of halothane, and urine from patients anesthetized with halothane also were tested. Halothane, trifluoroacetic acid, and patients'  urines were not mutagenic.
mesh_terms: D000611:Aminobiphenyl Compounds / Q000009:adverse effects; D000769:Anesthesia, Inhalation; D000818:Animals; D004000:Dichloroethylenes / Q000009:adverse effects; D005827:Genetics, Microbial; D006221:Halothane / Q000009:adverse effects* / Q000652:urine; D006801:Humans; D008297:Male; D009154:Mutation / Q000187:drug effects*; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects
chemical_list: D000611:Aminobiphenyl Compounds; D004000:Dichloroethylenes; D006221:Halothane