[Characteristics of the hypothalamo-hypophyseal regulation and morphological and functional state of the reproductive organs in female rats, androgenized in the neonatal period, depending on the time of the action of testosterone].
Testosterone propionate was injected to rats in a dose of 150 microng on the 2nd, 3rd and 4th day or in a dose of 500 microng on the 5th day after birth. Histological picture of the ovaries, vagina and uterus, the content of progesterone and its C20-restored metabolite in the ovaries, the LH-releasing activity of the hypothalamus, and the LH and FSH in the adenohypophysis were studied in these rats at the age of 3-5 months. The effects of the neonatal andronization of rats proved to depend on the time of testosterone action at all the levels of the hypothalamus-hypophysis-ovaries-accessory organs. Early administration of androgen caused more severe injuries of the reproductive system.
D000818:Animals; D000831:Animals, Newborn; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D005836:Genitalia, Female / Q000187:drug effects*; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects*; D007031:Hypothalamus / Q000378:metabolism; D007986:Luteinizing Hormone / Q000378:metabolism; D010053:Ovary / Q000166:cytology / Q000378:metabolism; D010903:Pituitary Gland, Anterior / Q000378:metabolism; D011280:Pregnanolone / Q000378:metabolism; D011374:Progesterone / Q000378:metabolism; D013739:Testosterone / Q000031:analogs & derivatives* / Q000494:pharmacology; D045165:Testosterone Congeners / Q000494:pharmacology*; D013997:Time Factors; D014599:Uterus / Q000166:cytology; D014621:Vagina / Q000166:cytology
D045165:Testosterone Congeners; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D011374:Progesterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D011280:Pregnanolone
Osobennosti gipotalamo-gipofizarnoĭ reguliatsii, morfologicheskogo i funktsional'nogo sostoianiia reproduktivnykh organov u neonatal'no androgenizirovannykh samok krys v zavisimosti ot vremeni vozdeistviia testosterona