The synthesis of S-adenosylmethionine by mutants with defects in S-adenosylmethionine synthetase.
Some metK mutants of Salmonella typhimurium with constitutive methionine biosynthesis have no detectable S-adenosylmethionine (SAM) synthetase, the enzyme which converts methionine to SAM, the postulated corepressor of the methionine pathway. However, these mutants are not auxotrophic for SAM, an essential compound for many reactions.
D004794:Enzyme Repression; D005796:Genes; D008716:Methionine Adenosyltransferase / Q000378:metabolism*; D009154:Mutation; D012436:S-Adenosylmethionine / Q000096:biosynthesis*; D012483:Salmonella Phages; D012486:Salmonella typhimurium / Q000201:enzymology*; D014161:Transduction, Genetic; D014166:Transferases / Q000378:metabolism*
D012436:S-Adenosylmethionine; D014166:Transferases; D008716:Methionine Adenosyltransferase