Continuous monitoring of the effect of pentagastrin on gastric emptying of solid food in man.
By continuous monitoring of a solid meal labelled with a radiopharmaceutical it has been possible to determine the effects of drugs on gastric emptying and motility during a single study. Predictably hyoscine delayed, and bethanechol increased, the rate of gastric emptying. Pentagastrin initially produced marked antral activity resulting in a physiological stricture and subsequent delay in the overall rate of gastric emptying. Fundal motility was unaffected though reflux from the antrum occurred.
D005769:Gastrointestinal Motility / Q000187:drug effects*; D006801:Humans; D008297:Male; D010418:Pentagastrin / Q000494:pharmacology*; D011706:Pyloric Antrum / Q000187:drug effects; D011877:Radionuclide Imaging; D013270:Stomach / Q000187:drug effects / Q000502:physiology; D013667:Technetium
D013667:Technetium; D010418:Pentagastrin