title: The effect of potassium on the activity of auditory nerve fibres of the guinea pig cochlea.
abstract: Scala tympani of the guinea pig cochlea was perfused with solutions having an increased potassium concentration. The response characteristics of single auditory nerve fibres in both normal and kanamycin-damaged cochleas were studied using computer controlled routines. The results indicate that these perfusions caused a marked increase in the spontaneous firing rate of auditory nerve fibres, without loss of threshold sensitivity. Current theories of cochlear transduction support the view that the potassium concentration difference across the reticular plate is fundamental to the sensitivity of the cochlea. The results presented here do not support this view.
mesh_terms: D000161:Acoustic Stimulation; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D003051:Cochlea / Q000187:drug effects*; D006168:Guinea Pigs; D007612:Kanamycin / Q000494:pharmacology; D009412:Nerve Fibers / Q000187:drug effects; D010477:Perfusion; D011188:Potassium / Q000494:pharmacology*; D012533:Scala Tympani / Q000187:drug effects; D000159:Vestibulocochlear Nerve / Q000187:drug effects*
chemical_list: D007612:Kanamycin; D011188:Potassium