Calcium and secretion: distinction between two pools of glucose-sensitive calcium in pancreatic islets.
D-Glucose, but not L-glucose or 3-O-methyl-D-glucose, stimulates 45Ca2+ uptake by both lanthanum-displaceable and lanthanum-nondisplaceable pools in pancreatic islets. The nondisplaceable pool probably represents secretory granules, while the displaceable pool may be located in the beta-cell membrane. Kinetic studies with isotopically labeled islets suggest that only the displaceable pool participates in the short-term coupling of the glucose stimulus with secretion.
D000818:Animals; D001692:Biological Transport; D002118:Calcium / Q000378:metabolism*; D005947:Glucose / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000378:metabolism*; D007700:Kinetics; D007811:Lanthanum / Q000378:metabolism; D051379:Mice
D007328:Insulin; D007811:Lanthanum; D005947:Glucose; D002118:Calcium