title: [Dermatoses with transepithelial perforation (author's transl)].
abstract: The histologic concept of epidermal elimination of particulate matter was formulated by Pinkus in 1954. Mehregan enlarged on this by recognizing its fundamental role in a variety of skin diseases. The importance of this epidermal reaction pattern in five "perforating" dermatoses is stressed. Also, it is shown that active participation of the corium and epithelio-mesenchymal interaction are required for the iniation of this mechanism. The histological differentiation and histogenesis of the presented dermatoses are discussed.
mesh_terms: D003095:Collagen Diseases / Q000473:pathology; D007644:Darier Disease / Q000473:pathology; D004547:Elastic Tissue / Q000473:pathology; D005499:Folliculitis / Q000473:pathology; D005549:Foreign-Body Reaction; D006099:Granuloma / Q000473:pathology; D006801:Humans; D012867:Skin / Q000473:pathology*; D012871:Skin Diseases / Q000473:pathology*
vernacular_title: Dermatosen mit transepithelialer Perforation