Apparent recurrence of progressive systemic sclerosis in a renal allograft.
A young woman with progressive systemic sclerosis (PSS) and renal failure who received a renal transplant from her mother suffered accelerated loss of allograft function in the absence of hyperacute rejection or severe hypertension. A biopsy specimen and pathologic examination of the transplanted organ showed a fluorescent antibody pattern and vascular changes that were indistinguishable from those in the patient's native kidneys. This clinical sequence is a departure from the relative success of renal transplantation in the few previously reported cases of PSS where it has been used as therapy for renal failure.
D000208:Acute Disease; D000328:Adult; D005260:Female; D006084:Graft Rejection; D006801:Humans; D006973:Hypertension / Q000473:pathology; D007668:Kidney / Q000098:blood supply; D007676:Kidney Failure, Chronic / Q000473:pathology*; D016030:Kidney Transplantation; D009392:Nephrectomy; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000473:pathology*; D012008:Recurrence; D006435:Renal Dialysis; D012595:Scleroderma, Systemic / Q000473:pathology*; D014184:Transplantation, Homologous; D014652:Vascular Diseases / Q000473:pathology*