Bioassay of plant extracts for anticancer activity.
Crude plant products were first tested in the Drug Research and Development Program, Division of Cancer Treatment, NCI, in 1956. The first materials were voluntarily submitted and later materials were acquired through various contracts. A review is given of the tumor systems which have been used for the evaluation of these plant products and of in vitro assays utilized to expedite fractionation and isolation.
D000230:Adenocarcinoma / Q000188:drug therapy; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D001681:Biological Assay; D006801:Humans; D007939:Leukemia L1210 / Q000188:drug therapy; D009369:Neoplasms / Q000188:drug therapy*; D009374:Neoplasms, Experimental / Q000188:drug therapy; D010936:Plant Extracts / Q000627:therapeutic use; D012510:Sarcoma 180 / Q000188:drug therapy
D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts