Effects of antithymic reticuloepithelial cells serum on the levels of circulating thymic factor and on the sensitivity to azathioprine of spleen spontaneous rosette-forming cells.
Swiss mice treated with an antithymic reticuloepithelial cells serum (ATRES) showed a drastic and prolonged depression of the serum thymic factor. A similar but less pronounced effect was also observed following the administration of the antithymocyte (ATS) and the antilymphocyte (ALS) sera. Conversely, the azathioprine sensitivity of spleen spontaneous rosette-forming cells was highly modified by the ATRES but not by the ATS or the ALS. The probable mechanisms of such effects are discussed.
D000818:Animals; D000961:Antilymphocyte Serum / Q000494:pharmacology; D001379:Azathioprine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007106:Immune Sera / Q000494:pharmacology; D007158:Immunologic Techniques; D051379:Mice; D012157:Mononuclear Phagocyte System / Q000276:immunology*; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology*; D013951:Thymus Hormones / Q000097:blood*; D013997:Time Factors
D000961:Antilymphocyte Serum; D007106:Immune Sera; D013951:Thymus Hormones; D001379:Azathioprine