[Possible use of the platelet as the cell system for the control of enteropathogenicity of E. coli and of other enterobacteria. Preliminary approach].
After an introduction concerning the assays employed in vitro and in vivo to determine enterotoxigenic activity of E. coli, the A. suggests a new in vitro model as a preliminary approach based upon the influence of LT enterotoxin of Escherichia coli on platelet aggregation (inhibitory effect) as expression of stimulation of adenylatecyclase activity evoked by this fraction and eventually other cholera-like fractions released from enterobacteria.
D000818:Animals; D002850:Chromatography, Gel; D004751:Enteritis / Q000209:etiology; D004755:Enterobacteriaceae / Q000472:pathogenicity*; D004768:Enterotoxins / Q000494:pharmacology*; D004926:Escherichia coli / Q000472:pathogenicity*; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects*; D014734:Vibrio cholerae / Q000472:pathogenicity
D004768:Enterotoxins
Sul possibile impiego delle piastrine come sistema cellulare utilizzabile per la verifica della enteropatogenicita' di Escherichia coli e di altri enterobatteri. Approccio preliminare