Immunologic reconstitution in severe combined immunodeficiency following transplantation with parental bone marrow.
A 9-month-old girl with severe combined immunodeficiency was transplanted with BM cells from her father. The child had complete restoration of cell-mediated immune functions. Humoral immune functions remain absent nine months after transplant. Child and father were HL-A identical and their lymphocytes were nonreactive in mixed lymphocyte culture. The parents of the child were first cousins and shared an HL-A haplotype. In countries like Lebanon, where there is a high incidence of first-cousin marriages (15%) and where villages are relatively isolated, the search for histocompatible graft donors should extend beyond the siblings to other members of the family.
D001402:B-Lymphocytes / Q000276:immunology; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D003241:Consanguinity; D005260:Female; D006650:Histocompatibility Testing; D006801:Humans; D007111:Immunity, Cellular; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007153:Immunologic Deficiency Syndromes / Q000276:immunology*; D007223:Infant; D014184:Transplantation, Homologous
D007074:Immunoglobulin G; D007075:Immunoglobulin M