Metronidazole in prevention and treatment of bacteroides infections after appendicectomy.
The frequency of non-clostridial anaerobic infection was studied in 95 patients who had undergone acute appendicectomy: 49 received prophylactic metronidazole and 46 received placebo. Anaerobic infection did not develop in any of the metronidazole-treated patients, but infections did develop in nine (19%) of the 46 controls. Metronidazole is conveniently administered by suppository to patients who cannot take oral drugs. Five patients with intra-abdominal infections caused by non-clostridial anaerobes were successfully treated with metronidazole.
D000293:Adolescent; D000328:Adult; D001062:Appendectomy; D001439:Bacteroides / Q000302:isolation & purification; D001442:Bacteroides Infections / Q000188:drug therapy / Q000382:microbiology / Q000517:prevention & control*; D002648:Child; D002986:Clinical Trials as Topic; D006801:Humans; D008795:Metronidazole / Q000097:blood / Q000627:therapeutic use*; D010919:Placebos; D013488:Suppositories; D013530:Surgical Wound Infection / Q000188:drug therapy / Q000382:microbiology / Q000517:prevention & control*
D010919:Placebos; D013488:Suppositories; D008795:Metronidazole