Induction of pyloric hypertrophy by pentagastrin. An animal model for infantile hypertrophic pyloric stenosis.
Administration of pentagastrin in depot form to 20 pregnant bitches produced pyloric hypertrophy in about 28% and gastroduodenal ulceration in about 16% of their pups. The two lesions were not necessarily found in the same individuals. Histological appearances of the pylorus in affected pups closely resembled those of human infantile pyloric stenosis.
D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D005260:Female; D006984:Hypertrophy; D008431:Maternal-Fetal Exchange; D010418:Pentagastrin / Q000008:administration & dosage; D010437:Peptic Ulcer / Q000139:chemically induced; D011247:Pregnancy; D011707:Pyloric Stenosis / Q000139:chemically induced* / Q000151:congenital / Q000473:pathology; D011708:Pylorus / Q000473:pathology
D010418:Pentagastrin