Trial of an oral antigen against upper respiratory-tract infection. Results in the second year (1973-74).
A double-blind trial in two randomly structured groups of boarders (44 girls and 66 boys) aged 7 to 13 years was undertaken in two Bristrol schools. Dosage was 1 ml a day of fluid (antigen or placebo) orally for the first four weeks of the autumn term, absenteeism being the main parameter measured, using a structured recording code. There was a highly significant difference in the number of days lost from upper respiratory-tract infection in the treated as opposed to the placebo group (x2 = 40-00 P less than 0-001 (v = 1). The number of colds was also significantly lower in the treated group (x2 = 8-05 P less than 0-005 (V less than i)).
D000041:Absenteeism; D000284:Administration, Oral; D000293:Adolescent; D000942:Antigens, Bacterial / Q000008:administration & dosage*; D002648:Child; D002986:Clinical Trials as Topic; D003139:Common Cold / Q000145:classification / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008297:Male; D010919:Placebos
D000942:Antigens, Bacterial; D010919:Placebos