The involvement of serotonin in the mechanism of central action of apomorphine.
The paper reviews and summarizes the results obtained in a series of experimental papers on the action of apomorphine on central serotonin mechanisms. Apomorphine accelerates utilization of serotonin in the central nervous system, this effect being a consequence of stimulation of central dopamine receptors. The activation of serotonergic mechanisms may be responsible for the hypothermizing action of apomorphine in rats and mice, pi modulates the locomotor stimulation produced by apomorphine in the rat, and does not influence the apomorphine-induced stereotypy in the rat.
D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology; D001058:Apomorphine / Q000494:pharmacology*; D001831:Body Temperature / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D001923:Brain Chemistry / Q000187:drug effects; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009474:Neurons / Q000187:drug effects; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects; D011985:Receptors, Serotonin / Q000187:drug effects; D012701:Serotonin / Q000378:metabolism*; D013239:Stereotyped Behavior / Q000187:drug effects; D013268:Stimulation, Chemical
D000929:Antidepressive Agents, Tricyclic; D011954:Receptors, Dopamine; D011985:Receptors, Serotonin; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D001058:Apomorphine