Effect of the thymus on erythropoietin production in response to hypobaric hypoxia in mice.
Thymectomized, irradiated and syngeneic bone marrow-repopulated (TIR) mice, after hemopoietic recovery, were more effective in producing erythropoietin than normal controls in response to hypobaric hypoxia. Mice which were only thmectomized responded to hypoxia with more erythropoietin production than controls but less than TIR animals. It is suggested that lymphoid elements of thymic origin may produce inhibitors of the erythropoietic system. This may play a role in the anemia of lymphomas and certain other clinical syndromes.
D000818:Animals; D001274:Atmospheric Pressure; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D004921:Erythropoietin / Q000096:biosynthesis*; D005260:Female; D000860:Hypoxia / Q000503:physiopathology*; D007504:Iron Radioisotopes; D007668:Kidney / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D013950:Thymus Gland / Q000502:physiology / Q000503:physiopathology*; D014184:Transplantation, Homologous
D007504:Iron Radioisotopes; D004921:Erythropoietin