Lack of release of human chorionic gonadotropin by gonadotropin-releasing hormone.
The effects of either single injection or continuous infusion of synthetic Gn-RH on plasma hCG levels were studied in 5 pregnant women (14-38 week gestation). No definite increase of hCG level was seen in all the cases studied. In view of large dosages of Gn-RH used in this study in comparison with its minimum effective dose for the pituitary gonadotropin release, Gn-RH seems unlikely to play a role in hCG secretion during human pregnancy.
D006063:Chorionic Gonadotropin / Q000097:blood*; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D007267:Injections; D010906:Pituitary Hormone-Releasing Hormones / Q000008:administration & dosage / Q000494:pharmacology*; D011247:Pregnancy
D006063:Chorionic Gonadotropin; D010906:Pituitary Hormone-Releasing Hormones