Impaired theophylline clearance in patients with cor pulmonale.
1  The relationship between serum theophylline concentration and daily dose was studied in 45 patients receiving aminophylline orally and in 36 patients receiving it by constant intravenous infusion. 2  Patients were categorized as uncomplicated chronic obstructive pulmonary disease (COPD) or COPD with cor pulmonale (CP). 3  Serum theophylline concentration relative to daily theophylline dose was significantly higher in patients with COPD plus CP than in patients with COPD alone. 4  Total body clearance of theophylline estimated from data obtained during constant intravenous infusion was significantly lower in COPD plus CP than in patients with COPD alone. 5  We conclude that reduced maintenance doses of theophylline are indicated in patients with COPD when complicated with CP.
D000284:Administration, Oral; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008173:Lung Diseases, Obstructive / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011660:Pulmonary Heart Disease / Q000378:metabolism*; D013806:Theophylline / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*
D013806:Theophylline