title: [Uric-acid reduction with high allopurinol dosages (author's transl)].
abstract: At the high dosage of 600 mg daily, the uric-acid reducing effect of allopurinol depends on the initial level of uric-acid concentration in the same manner as at the usual dosage of 300 mg daily, but is more marked at the entire hyperuricaemic concentration range of 65--71 mumol/l (11--12 mg/l). After eight days at the same dosage of 600 mg daily allopurinol there is a highly significant correlation between the two variables, corresponding to the equation of uric acid effect of allopurinol = 0.893 x serum uric-acid concentration--29.27. At an uric-acid concentration of 476 mumol/l (80 mg/l); at a uric-acid level of about 595 mumol/l (100 mg/l) the average concentration reduction will be around 357 mumol/l (60 mg/l).
mesh_terms: D000368:Aged; D000493:Allopurinol / Q000008:administration & dosage* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005260:Female; D006073:Gout / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid; D000493:Allopurinol
vernacular_title: Wirkungsprofil der Harnsäuresenkung bei Höherdosierung von Allopurinol.