Recipient selection for renal retransplantation.
Analysis of over 1,000 kidney retransplants revealed an important effect of first graft duration and presensitization on graft outcome. Second cadaver donor grafts into patients without preformed cytotoxic antibodies and a first graft duration of more than 12 months survived at a high 1-year rate of 71 +/- 6%, in contrast to 29 +/- 6% in those whose first graft had failed in 1-3 months (P is less than 0.0001). Third or fourth transplants into patients with preformed cytotoxins survived at the poor rate of 17 +/- 6% at 1 year. To repeat all HLA mismatches from the first graft was found to result in decreased second graft survival.
D002102:Cadaver; D002874:Chromosome Mapping; D003601:Cytotoxicity Tests, Immunologic; D006084:Graft Rejection; D006650:Histocompatibility Testing; D006801:Humans; D016030:Kidney Transplantation; D008233:Lymphotoxin-alpha / Q000032:analysis; D013997:Time Factors; D014184:Transplantation, Homologous
D008233:Lymphotoxin-alpha