Experimental infections of sheep with Salmonella typhimurium.
Twenty-two-six-to nine-month-old lambs were infected orally with Salmonella typhimurium at levels varying from 2 x 10(13) to 1 x 10(9) and serially slaughtered to determine the pathogenesis of infection and to evaluate the efficacy of diagnostic procedures. Infection resulted in a severe fatal or potentially fatal clinical disease in lambs receiving 2 x 10(13) organisms. Observations were made on the clinical pathology, bacteriology and serology during the course of infection and extensive bacteriological examinations were undertaken at autopsy.
D000818:Animals; D005243:Feces / Q000382:microbiology; D006400:Hematocrit; D007421:Intestine, Small / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D012481:Salmonella Infections, Animal / Q000382:microbiology / Q000473:pathology; D012486:Salmonella typhimurium / Q000302:isolation & purification; D012756:Sheep; D012757:Sheep Diseases / Q000382:microbiology / Q000473:pathology