[Comparative study of the effect of inhibitors of monoamine oxidase and ftorafur on the growth of de-differentiated astrocytoma].
To evaluate the possible antitumour effect of intensified deposition of serotonin in the region of localization of the tumour caused by a pharmacological preparation studies of the effect of inhibitors of monoamine oxidase transamine and N2N2-dibenzylhydrazide of DL-malic acid on rat's cerebellum tumour de-differentiated by astrocytoma (strain No 101/12) were carried out. The effect of inhibitors of monoamine oxidase was compared with that of antiblastic preparation of phthorafur. Differences in the mechanisms of action of pharmacological agents referred to above are shown. It was established that inhibitors of monoamine oxidase administered against the background of the developing tumour caused a considerable reduction in its weight and prononced dystrophic and necrotic changes.
D000818:Animals; D001254:Astrocytoma / Q000032:analysis / Q000188:drug therapy / Q000473:pathology*; D002528:Cerebellar Neoplasms / Q000032:analysis / Q000188:drug therapy / Q000473:pathology*; D004341:Drug Evaluation; D005472:Fluorouracil / Q000031:analogs & derivatives*; D008996:Monoamine Oxidase Inhibitors / Q000627:therapeutic use*; D009374:Neoplasms, Experimental / Q000032:analysis / Q000188:drug therapy / Q000473:pathology*; D051381:Rats; D012701:Serotonin / Q000032:analysis; D005641:Tegafur / Q000627:therapeutic use*
D008996:Monoamine Oxidase Inhibitors; D005641:Tegafur; D012701:Serotonin; D005472:Fluorouracil
Sravnitel'noe izuchenie deĭstviia ingibitorov monoaminoksidazy i ftorafura na rost dedifferentsirovannoĭ astrotsitomy