title: On the structure-activity relationship of antiviral substances.
abstract: The significance of the study on structure-activity relationship in the antiviral substances is considered for: 1. directed synthesis of highly active and selective antivirals; 2. elucidation of the mechanism of action of antiviral substances by revealing the chemical structures which determine the inhibition of a given step in the virus growth cycle. The basic trends in conducting directed synthesis of antiviral substances are pointed out: synthesis of new inhibitors with a broad antiviral spectrum, as well as improvement by structural modifications of known ones. The basic methodological approaches in the structure-activity studies are considered. A classification of the available antiviral synthetic substances is presented.
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000998:Antiviral Agents / Q000494:pharmacology*; D001562:Benzimidazoles / Q000494:pharmacology; D001952:Bridged-Ring Compounds / Q000494:pharmacology; D003538:Cystamine / Q000494:pharmacology; D003553:Cystine / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D010879:Piperazines / Q000494:pharmacology; D011684:Purine Nucleosides / Q000494:pharmacology; D011685:Purine Nucleotides / Q000494:pharmacology; D011741:Pyrimidine Nucleosides / Q000494:pharmacology; D011742:Pyrimidine Nucleotides / Q000494:pharmacology; D012324:RNA-Dependent RNA Polymerase / Q000037:antagonists & inhibitors; D012254:Ribavirin / Q000494:pharmacology; D012643:Selenium / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013882:Thiosemicarbazones / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; D001562:Benzimidazoles; D001952:Bridged-Ring Compounds; D010879:Piperazines; D011684:Purine Nucleosides; D011685:Purine Nucleotides; D011741:Pyrimidine Nucleosides; D011742:Pyrimidine Nucleotides; D013882:Thiosemicarbazones; D003553:Cystine; D012254:Ribavirin; D012324:RNA-Dependent RNA Polymerase; D012643:Selenium; D003538:Cystamine