title: [Mutagenic activity of benzonal].
abstract: Benzonalum mutagenic activity was demonstrated in a dominant lethal test on mice. The late spermatids stage proved to be the most sensitive in this respect. The benzonalum did not evoke any cytogenetic activity, that was shown by counting chromosome aberrations in metaphases of the bone marrow cells in vivo and did not induce gene mutations in tester trains of Salmonella typhimurium in vitro and in vivo (a host-mediated assay).
mesh_terms: D000818:Animals; D001463:Barbiturates / Q000633:toxicity*; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D002869:Chromosome Aberrations; D005799:Genes, Dominant; D005804:Genes, Lethal; D008297:Male; D051379:Mice; D009153:Mutagens; D009154:Mutation; D012486:Salmonella typhimurium / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects
chemical_list: D001463:Barbiturates; D009153:Mutagens
vernacular_title: Otsenka mutagennoĭ aktivnosti benzonala