Permeability to cobalt ions and action of colicin K in a mutant that overproduces cardiolipin.
A mutant of Escherichia coli that produces excess cardiolipin becomes less capable of transporting Co2+. Cardiolipin therefore does not act as an ionophore under these conditions. Colicin K brings about the typical increase in permeability to Co2+ in the mutant.
D002258:Carbonyl Cyanide m-Chlorophenyl Hydrazone / Q000494:pharmacology; D002308:Cardiolipins / Q000096:biosynthesis*; D002463:Cell Membrane Permeability / Q000187:drug effects; D003035:Cobalt / Q000378:metabolism*; D003087:Colicins / Q000494:pharmacology*; D004926:Escherichia coli / Q000378:metabolism*; D009154:Mutation
D002308:Cardiolipins; D003087:Colicins; D003035:Cobalt; D002258:Carbonyl Cyanide m-Chlorophenyl Hydrazone