Variability of protection in inbred mice induced by a ribosomal vaccine prepared from Salmonella typhimurium.
Ribosomal vaccines prepared from Salmonella typhimurium were effective immunogens in A/J inbred mice and C3H/HeTex, inbred mice. However, ribosomal vaccines were not protective in C57BL/6J inbred mice. A/J mice were protected against lethal challenge by attenuated S. typhimurium live-cell, ribosomal, phenol, and heat-killed vaccines. C3H/HeTex mice were protected by live-cell, ribosomal, and phenol vaccines but not the heat-killed vaccine. Only the live-cell vaccine gave significant protection in the C57BL/6J inbred mice. A comparison of the kinetics of infection in sham-immunized mice and mice immunized with ribosomes showed that ribosome preparations elicited protection against Salmonella infection in mice inherently sensitive and resistant to Salmonella.
D000818:Animals; D001428:Bacterial Vaccines / Q000008:administration & dosage; D007700:Kinetics; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D012270:Ribosomes / Q000276:immunology*; D012481:Salmonella Infections, Animal / Q000517:prevention & control*; D012486:Salmonella typhimurium / Q000276:immunology*; D013045:Species Specificity; D014611:Vaccination
D001428:Bacterial Vaccines