Ultrastructural studies of the mechanism of changes developing in pemphigoid using peroxidase-labeled antibodies.
The application of peroxidase-labeled antiserum to human gamma globulin allowed the immunological reaction in vivo to be localized in the basement membrane, particularly in its part termed the lucid zone. The bulla is formed between the basal cell membrane and the dark lamina of the basement membrane.
D000941:Antigens; D001323:Autoantibodies / Q000032:analysis*; D001485:Basement Membrane / Q000276:immunology / Q000648:ultrastructure; D001665:Binding Sites; D002462:Cell Membrane / Q000648:ultrastructure; D003886:Descemet Membrane / Q000648:ultrastructure; D006801:Humans; D007106:Immune Sera; D007136:Immunoglobulins; D010544:Peroxidases; D012872:Skin Diseases, Vesiculobullous / Q000276:immunology / Q000473:pathology*
D000941:Antigens; D001323:Autoantibodies; D007106:Immune Sera; D007136:Immunoglobulins; D010544:Peroxidases