title: Treatment of external ocular Candida infections with 5-fluorocytosine.
abstract: 15 patients who suffered from severe and prolonged external Candida ocular infections and who had not responded to Mycostatin and/or Amphotericin B treatment, were successfully treated with 5-Fluorocytosine administered topically or combined topical-orally. In all patients, a cure was achieved after a treatment period of approximately 6 months. No side effects were observed and no resistance to the drug developed.
mesh_terms: D000284:Administration, Oral; D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000368:Aged; D002176:Candida albicans; D002177:Candidiasis / Q000188:drug therapy*; D003231:Conjunctivitis / Q000188:drug therapy*; D003320:Corneal Ulcer / Q000188:drug therapy*; D003596:Cytosine / Q000031:analogs & derivatives*; D005260:Female; D005437:Flucytosine / Q000008:administration & dosage; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged
chemical_list: D003596:Cytosine; D005437:Flucytosine