Prolongation of skin graft survival by sodium-copper-chlorophyllin. Inhibition of the first- and second-set phenomenon.
Sodium-copper-chlorophyllin which has a strong anticomplementary and membrane-stabilizing effect also has, by these mechanisms, a strong immunosuppressive competence. In HAN-rotation-breeded Wistar rats there is a time- and dose-dependent prolongation of skin allograft survival by this drug. The first-set and the second-set phenomena are inhibited.
D000818:Animals; D002734:Chlorophyll / Q000031:analogs & derivatives* / Q000494:pharmacology; D003300:Copper / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D006084:Graft Rejection / Q000187:drug effects*; D051381:Rats; D016038:Skin Transplantation; D012964:Sodium / Q000494:pharmacology; D013997:Time Factors; D014022:Tissue Survival / Q000187:drug effects*
D002734:Chlorophyll; D003300:Copper; D012964:Sodium