Rat intestinal glycoprotein lowering bactericidal activity of serum on 32P-labelled E. coli.
A glycoprotein fraction, by which the 32P-releasing activity of serum on labelled E. coli is lowered, was isolated from caecum content of germfree rats. The glycoprotein contained 83.1% sulphate, and 16.1% protein. The molecular weight ranged from 3.2 X 10(5) to 2.4 X 10(6), and the iso-electric point from pH 0.9 to 3.0. Physiologically, it may play a role in the interaction(s) between the host and its intestinal flora.
D000818:Animals; D001770:Blood Bactericidal Activity / Q000187:drug effects*; D001894:Borohydrides / Q000494:pharmacology; D002241:Carbohydrates / Q000032:analysis; D002432:Cecum / Q000032:analysis; D002850:Chromatography, Gel; D002853:Chromatography, Liquid; D004587:Electrophoresis, Agar Gel; D004926:Escherichia coli; D006023:Glycoproteins / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology*; D007413:Intestinal Mucosa / Q000032:analysis; D007525:Isoelectric Focusing; D008970:Molecular Weight; D009005:Monosaccharides / Q000494:pharmacology; D009077:Mucins / Q000032:analysis; D009439:Neuraminidase / Q000494:pharmacology; D051381:Rats; D012260:Ribonucleases / Q000494:pharmacology; D013431:Sulfates / Q000032:analysis
D001894:Borohydrides; D002241:Carbohydrates; D006023:Glycoproteins; D009005:Monosaccharides; D009077:Mucins; D013431:Sulfates; D012260:Ribonucleases; D009439:Neuraminidase