Antiinflammatory drugs and gastrointestinal bleeding: a comparison of aspirin and ibuprofen.
Gastrointestinal blood loss provoked by short-term and long-term therapy with aspirin and ibuprofen was compared in patients with rheumatoid arthritis. Blood loss was assessed by isotope counting of four-day stool collections after infusion of 51Cr-labeled autologous erythrocytes. After two weeks on drug or after one year on drug, aspirin consistently caused more bleeding than ibuprofen.
D000328:Adult; D000368:Aged; D001241:Aspirin / Q000009:adverse effects*; D002986:Clinical Trials as Topic; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced*; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009780:Occult Blood; D010666:Phenylpropionates / Q000009:adverse effects*
D010666:Phenylpropionates; D001241:Aspirin; D007052:Ibuprofen