Immune and phagocytic function in patients on maintenance dialysis and post-transplantation.
Immune, phagocytic and opsonic function was assessed in stabilized hemodialysis patients and compared with patients on maintenance immunosuppression following successful renal transplantation. Dialysis patients had a lymphopenia and a qualitative defect in lymphocyte function but opsonic and neutrophil metabolic function was normal. Post-transplant patients had normal intrinsic lymphocyte function but overall immunosuppression due to lymphopenia, selective T cell depletion, and drug inhibition. Neutrophil metabolic function was normal though there was a defect in opsonization.
D001402:B-Lymphocytes; D002176:Candida albicans; D003165:Complement System Proteins / Q000032:analysis; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007165:Immunosuppression Therapy; D007455:Iodine / Q000378:metabolism; D016030:Kidney Transplantation; D037102:Lectins; D007958:Leukocyte Count; D007962:Leukocytes / Q000378:metabolism / Q000502:physiology*; D008213:Lymphocyte Activation; D009895:Opsonin Proteins / Q000096:biosynthesis; D010587:Phagocytosis; D006435:Renal Dialysis; D013211:Staphylococcus aureus; D013601:T-Lymphocytes; D014184:Transplantation, Homologous
D007136:Immunoglobulins; D037102:Lectins; D009895:Opsonin Proteins; D003165:Complement System Proteins; D007455:Iodine