title: [Bone marrow transplantation in leukemia: possibilities and problems].
abstract: At present, clinical bone marrow transplantation has reached such an advanced stage that it offers a chance of permanent cure to some patients with acute refractory leukemias. Prerequisites for successful marrow grafts are: careful histocompatibility typing of donor and host, favourable timing of the graft, which should not be performed in the absolutely terminal stages of the disease; optimum conditioning of the recipient, which should aim not only at immunosuppression to allow a marrow take but at maximum reduction of the tumor load; a well-trained team in supportive care and wide experimental and clinical experience in marrow grafting. For the time being only HL-A-identical, MLC-negative siblings or identical twins should be used as marrow donors.
mesh_terms: D000328:Adult; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D002648:Child; D004203:Disinfection; D005260:Female; D006648:Histocompatibility; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000628:therapy*; D008297:Male; D008578:Meninges; D008727:Methotrexate / Q000627:therapeutic use; D010357:Patient Isolators; D011247:Pregnancy; D011658:Pulmonary Fibrosis / Q000150:complications; D014184:Transplantation, Homologous; D014185:Transplantation, Isogeneic; D014430:Twins, Monozygotic
chemical_list: D000903:Antibiotics, Antineoplastic; D008727:Methotrexate
vernacular_title: Knochenmarktransplantation bei Leukämie: Möglichkeiten, Probleme