title: Hyperlipidemia in pediatric hemodialysis and renal transplant patients. Associated with coronary artery disease.
abstract: Fasting serum cholesterol and serum triglyceride levels were determined in 15 maintenance hemodialysis (MH) and 35 renal transplant (RT) patients. Fourteen of 15 MH patients (93%) had elevated triglyceride levels (greater than 140 mg/100 ml) compared to 11 of 35 RT recipients (31%) (P less than .001). Two of 15 MH patients (13%) had elevated cholesterol levels (greater than 230 mg/100 ml), compared to 18 of 35 RT recipients (51%) (P = .03). In MH patients, a positive correlation was noted between serum triglyceride levels and carbohydrate intake (P = .03). Autopsy material from 12 children who underwent MH or RT was compared to material from 16 age-matched controls; an increased collagenous content of intima, a possible early indicator of coronary artery disease, was noted more frequently (P less than .006) in index patients compared to controls. Our data demonstrate that hyperlipidemia is a frequent finding in pediatric patients treated with MH and RT, and may be associated with premature coronary artery disease.
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002784:Cholesterol / Q000097:blood; D003327:Coronary Disease / Q000097:blood / Q000209:etiology* / Q000473:pathology; D003331:Coronary Vessels / Q000473:pathology; D004040:Dietary Carbohydrates; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000209:etiology*; D007165:Immunosuppression Therapy; D007223:Infant; D016030:Kidney Transplantation; D008297:Male; D011183:Postoperative Complications; D011241:Prednisone / Q000627:therapeutic use; D006435:Renal Dialysis / Q000009:adverse effects*; D014184:Transplantation, Homologous / Q000009:adverse effects; D014280:Triglycerides / Q000097:blood
chemical_list: D004040:Dietary Carbohydrates; D014280:Triglycerides; D002784:Cholesterol; D011241:Prednisone