Inhibition of secretin stimulated pancreatic secretion by pancreatic polypeptide.
The effect of PP on secretin-stimulated pancreatic secretion was assessed in five healthy subjects. During an intravenous infusion of BPP at a dose which produced plasma levels similar to those seen after meals in healthy young adults the volume and bicarbonate content of duodenal juice was reduced by 25% (p less than 0.05) and 24% (p less than 0.05) respectively, while protein and bilirubin concentrations were more markedly reduced by 68% (p less than 0.0005) and 67% (p less than 0.0005) respectively.  PP, thus, may be an important inhibitory factor in the control of bilirubin and pancreatic enzyme secretion in man.
D000328:Adult; D001639:Bicarbonates / Q000378:metabolism; D001663:Bilirubin / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D010179:Pancreas / Q000378:metabolism*; D010189:Pancreatic Juice / Q000378:metabolism; D010191:Pancreatic Polypeptide / Q000494:pharmacology*; D011506:Proteins / Q000378:metabolism; D012633:Secretin / Q000037:antagonists & inhibitors*; D012636:Secretory Rate / Q000187:drug effects; D013997:Time Factors; D014357:Trypsin / Q000378:metabolism
D001639:Bicarbonates; D011506:Proteins; D012633:Secretin; D010191:Pancreatic Polypeptide; D014357:Trypsin; D001663:Bilirubin