title: Experimental cellular allergic reactions in normal canine and malignant human prostate.
abstract: This paper describes the histopathology of chronic tuberculin-type hypersensitivity reactions in the normal canine and malignant human prostate. Seven dogs were sensitized by injection of Freund's complete adjuvant and the histological response to the subsequent intra-prostatic injection of 6 mg tuberculin PPD was documented. A chronic mononuclear cell prostatis persisted for 4 weeks and was accompanied by paracortical distension and follicular hyperplasia in regional lymph nodes. Six patients with carcinoma of the prostate were given multiple intraprostatic injections of BCG, which induced a chronic mononuclear cell prostatitis with some evidence of tumour-cell necrosis. The study indicated that the prostate can support chronic cell-mediated allergic reactions to extrinsic antigens and that intra-prostatic injections of BCG can be administered without harmful effects to patients with malignant prostatic disease.
mesh_terms: D000230:Adenocarcinoma / Q000276:immunology / Q000473:pathology; D000818:Animals; D001500:BCG Vaccine; D004285:Dogs; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000473:pathology; D007111:Immunity, Cellular; D008214:Lymphocytes; D008297:Male; D009163:Mycobacterium bovis; D011467:Prostate / Q000276:immunology* / Q000473:pathology; D011471:Prostatic Neoplasms / Q000276:immunology* / Q000473:pathology; D011472:Prostatitis / Q000276:immunology / Q000473:pathology; D014373:Tuberculin
chemical_list: D001500:BCG Vaccine; D014373:Tuberculin