title: Sensitivity of Escherichia coli after exposure to lincomycin in vitro and in vivo.
abstract: Exposure of 10 Escherichia coli isolates in vitro to a concentration of lincomycin found in the intestine of swine fed the maximun concentration recommended in feed did not significantly affect sensitivity to 8 antibiotics, 1 nitrofuran, and 1 sulfonamide when compared with sensitivity of E coli isolates not exposed to lincomycin. Changes in sensitivity, on the basis of Kirby-Bauer interpretation, did occasionally occur; however, these alterations were in zonal sizes, which were marginal for designation as sensitive, intermediate, or resistant. These same fluctuations were observed in E coli not exposed to lincomycin. Exposure of E coli to lincomycin in the intestinal tract of swine for 34 days did not alter sensitivity of E coli to tetracycline, dihydrostreptomycin, spectinomycin, lincomycin, or triple sulfa. The results indicated that addition of lincomycin to the feed did not appear to promote resistance transfer in E coli.
mesh_terms: D000667:Ampicillin / Q000494:pharmacology; D000818:Animals; D004917:Erythromycin / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects* / Q000302:isolation & purification; D005260:Female; D007420:Intestine, Large / Q000382:microbiology; D007421:Intestine, Small / Q000382:microbiology; D008034:Lincomycin / Q000378:metabolism / Q000494:pharmacology*; D008297:Male; D009355:Neomycin / Q000494:pharmacology; D009582:Nitrofurantoin / Q000494:pharmacology; D010403:Penicillin Resistance; D013552:Swine / Q000378:metabolism; D013754:Tetracyclines / Q000494:pharmacology
chemical_list: D013754:Tetracyclines; D004917:Erythromycin; D000667:Ampicillin; D009582:Nitrofurantoin; D008034:Lincomycin; D009355:Neomycin