title: A clinical Trial of Tofranil in osteo-arthritis.
abstract: Animal experiments and uncontrolled clinical experience indicate that imipramine should relieve pain or enhance the effect of analgesics in osteoarthritis. A double-blind crossover trial using Tofranil 25 mg three times daily and matching placebo has, therefore, been designed and initiated.
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D006801:Humans; D007099:Imipramine / Q000008:administration & dosage / Q000627:therapeutic use*; D010003:Osteoarthritis / Q000503:physiopathology*; D010146:Pain / Q000188:drug therapy*
chemical_list: D000082:Acetaminophen; D007099:Imipramine