title: [Interactions between nitrous oxide and central depressants].
abstract: The combined effects on mice of N2O and various central depressants were investigated. A loss of the righting reflex was taken as the criterion for the drug effects. Essential differences could be demonstrated in the type of interaction: diazepam, flunitrazepam, and medazepam have a supra-additive effect in combination with N2O; the solvent of diazepam and an experimental product, Ro 21-3981 (8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo [1,5-a] [1,4]-benzodiazepine maleate) a simply additive one. However, the interactions between N2O and barbiturates (pentobarbitone and phenobarbitone), and N2O and ethanol were found to be infra-additive. The results of this and previous investigations indicate that additive or supra-additive interactions can only be expected in those cases in which at most one of the two active ingredients in addition to its depressive effect also exhibits an excitatory component.
mesh_terms: D000818:Animals; D001463:Barbiturates / Q000494:pharmacology; D001569:Benzodiazepines / Q000494:pharmacology*; D003975:Diazepam / Q000494:pharmacology; D004347:Drug Interactions; D004357:Drug Synergism; D000431:Ethanol / Q000494:pharmacology; D005445:Flunitrazepam / Q000494:pharmacology; D008297:Male; D008472:Medazepam / Q000494:pharmacology; D051379:Mice; D009609:Nitrous Oxide / Q000494:pharmacology*
chemical_list: D001463:Barbiturates; D001569:Benzodiazepines; D000431:Ethanol; D005445:Flunitrazepam; D009609:Nitrous Oxide; D008472:Medazepam; D003975:Diazepam
vernacular_title: Wechselwirkungen zwischen Stickoxydul und zentral dämpfend wirkenden Pharmaka.