Renal transplantation in the rat. III. The effect of colloidal and non-colloidal perfusates on the clearing of blood from the in vitro perfused rat kidney.
Rat kidneys were perfused in vitro with Perfadex (Gelin's solution) and a modified Collins' C3-solution with or without colloids. When the same flow rate was used the presence of 5% dextran 40, 5% albumin, or 10% albumin did not alter the clearing of 51Cr-tagged red blood cells. The main difference between the experimental groups was a significant increase in perfusion pressure when colloids were excluded from the perfusate. Results concerning the regional distribution of 51Cr-activity within the kidney are discussed.
D000418:Albumins / Q000494:pharmacology*; D000818:Animals; D003102:Colloids / Q000494:pharmacology*; D003911:Dextrans / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects; D016030:Kidney Transplantation; D008297:Male; D010477:Perfusion; D051381:Rats; D013268:Stimulation, Chemical; D013997:Time Factors; D014184:Transplantation, Homologous
D000418:Albumins; D003102:Colloids; D003911:Dextrans