title: [Morphological changes using live vaccine from the suppressor S. typhimurium revertant in model experiments].
abstract: The work of was aimed at the morphological study of the harmlessness and protective activity of the live salmonella vaccine prepared form the suppressor S. typhimurium revertant intended for the prophylaxis and treatment of carrier state after the sustained food poisoning. It was shown to model experiments on mice that oral immunization caused no development of pathological changes, and at the same time prevented the appearance of the disease in infection of the animals by the virulent strain--S. typhimurium No. 415 in a dose of 100 LD50. A marked immunomorphological reaction developed in the small intestine and the lymphoid organs.
mesh_terms: D000818:Animals; D001428:Bacterial Vaccines / Q000009:adverse effects / Q000627:therapeutic use; D002353:Carrier State / Q000517:prevention & control / Q000628:therapy; D051379:Mice; D009154:Mutation; D012480:Salmonella Infections / Q000517:prevention & control / Q000628:therapy; D012486:Salmonella typhimurium / Q000276:immunology* / Q000472:pathogenicity; D013489:Suppression, Genetic; D014774:Virulence
chemical_list: D001428:Bacterial Vaccines
vernacular_title: Morfologicheskie ismeneniia pri ispol'zovanii zhivoĭ vaktsiny iz supressornogo revertanta S. typhimurium v model'nykh opytakh