Induction of resistance or enhancement to a transplantable murine plasmacytoma by transfer of non-immune leucocytes.
Newborn mice have a lower spontaneous resistance to the growth of a syngeneic plasmacytoma (MOPC-460) as compared to adult mice. The transfer of different leucocyte populations from non-immunized adult donors to newborn mice influence in a dual way the resistance to MOPC-460 growth, depending on the number of cells transferred. The transfer of a low number of neutrophils, thymus or spleen cells enhances the MOPC-460 takes. Higher numbers of neutrophils, thymus or bone marrow cells induce an effective protenction. By contrast, macrophages over a dose of 1 X 10(4) constantly produce a reduction of tumour growth.
D000818:Animals; D000831:Animals, Newborn / Q000276:immunology; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D017708:Leukocyte Transfusion; D008264:Macrophages / Q000637:transplantation; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000276:immunology; D009504:Neutrophils / Q000637:transplantation; D010954:Plasmacytoma / Q000276:immunology*; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000637:transplantation; D014181:Transplantation Immunology; D014184:Transplantation, Homologous