title: Imipramine and rheumatoid factor.
abstract: It has been reported that imipramine reduces the titre of rheumatoid factor in schizophrenic patients. Twenty out-patients suffering from classical rheumatoid arthritis and having rheumatoid factor titre equal to, or greater than 1:64, were treated in a double-blind trial with imipramine 75 mg or matching placebo. In this study the dose of imipramine used failed to affect the levels of rheumatoid factor.
mesh_terms: D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000276:immunology*; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D007099:Imipramine / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012217:Rheumatoid Factor / Q000378:metabolism*; D011795:Surveys and Questionnaires
chemical_list: D012217:Rheumatoid Factor; D007099:Imipramine