Depression of bursal follicle formation by Candida albicans infections.
Sub-lethal i.v. inoculations of Candida albicans into 12-day-old chick embryos have been shown to cause a depression of follicle formation in the bursa of Fabricius. This depression occurred in the absence of any infection in the bursa, although candidal encephalitis was a frequent manifestation of the disseminated infection. A similar depression of bursal follicle formation was caused by the administration of viable C. albicans on to the embryonic chorio-allantoic membrane, in the absence of any disseminated infection. Non-viable extracts of disrupted C. albicans administered on to the chorioallantoic membrane also caused a depression of bursal follicle formation. This immunodeficiency produced by an endotoxin-like principle at a susceptible stage in the development of the chick has been considered in terms of human immunological development and the neonatal occurrence of C. albicans.
D000482:Allantois / Q000382:microbiology; D000818:Animals; D002060:Bursa of Fabricius / Q000196:embryology* / Q000382:microbiology / Q000473:pathology; D002176:Candida albicans; D002177:Candidiasis / Q000196:embryology* / Q000473:pathology; D002642:Chick Embryo; D002823:Chorion / Q000382:microbiology