title: Streptococcus mutans serotypes: some aspects of their identification, distribution, antigenic shifts, and relationship to caries.
abstract: For an immunologic point of view, several facts are worth consideration. S mutans can be separated into at least seven serotypes. Five of the types are based on antigens that may be specific for S mutans. One type, e, is related to the Lancefield group E streptocci, and one type, f, may lack an antigen that shows serological specificity. Analyses of plaque samples from individuals with a high caries activity have, in most instances, shown the presence of c, d, and possibly the g types. This does not necessarily mean that they are per se more cariogenic than the other types, but if all the serotypes cannot be combatted simultaneously, the c, d, and g types are an obvious first choice. S mutans strains do have antigens other than those used for serological identification, and it is not known which antigens can evoke antibodies with the highest protective capacity in humans. The phenomenon of antigenic shifts may make it possible for the bacteria to elude antibodies. However, the number of possible changes may be restricted. If certain antigens are of importance for the cariogenicity of S mutans, a change in their structure might result in a less cariogenic flora.
mesh_terms: D000293:Adolescent; D000942:Antigens, Bacterial / Q000145:classification; D002648:Child; D003731:Dental Caries / Q000382:microbiology; D005827:Genetics, Microbial; D006801:Humans; D007125:Immunogenetics; D011153:Population; D012703:Serotyping; D013291:Streptococcus / Q000145:classification*; D013295:Streptococcus mutans / Q000145:classification* / Q000276:immunology / Q000302:isolation & purification / Q000378:metabolism
chemical_list: D000942:Antigens, Bacterial