Ultrastructure of B-cells of Langerhans islets in rats after the administration of L-leucine.
The results of studies with electron microscope supported the earlier biochemical findings on the stimulation of insulin secretion with the aid of L-leucine. The changes of the cell organelles of B-cells showed that both the synthesis and the release of insulin were activated, while the secretion by specific granules was unchanged. The stimulation of B-cells was accompanied by numerous membrane-like structures ("myelin-like figures") which were presumably formed from the endoplasmic reticulum.
D000818:Animals; D006056:Golgi Apparatus / Q000187:drug effects / Q000648:ultrastructure; D006651:Histocytochemistry; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure*; D007930:Leucine / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D007328:Insulin; D007930:Leucine