Short term screening tests for carcinogens.
There are now short term tests with a high predictive value for mammalian carcinogens. Many of them are based on the ability to detect damage to DNA in bacteria or mammalian cells after metabolic activation by microsomal enzymes. Their introduction will enable provisional safety assessments to be made for the many thousands of industrial and environmental chemicals for which long-term animal testing cannot at present be considered.
D000818:Animals; D001419:Bacteria / Q000187:drug effects; D002273:Carcinogens / Q000378:metabolism / Q000494:pharmacology; D002274:Carcinogens, Environmental / Q000494:pharmacology; D002471:Cell Transformation, Neoplastic; D004247:DNA; D009154:Mutation / Q000187:drug effects; D009369:Neoplasms / Q000139:chemically induced
D002273:Carcinogens; D002274:Carcinogens, Environmental; D004247:DNA