title: Studies of immediate adverse reactions to different doses of a slow-release preparation of isoniazid.
abstract: 'Double-blind' studies were carried out to assess the incidence of immediate adverse reactions to different doses of a slow-release preparation of isoniazid (matrix isoniazid). Individual doses of 30 mg/kg matrix isoniazid were well-tolerated but higher doses resulted in giddiness, the incidence being dose-related. The giddiness was characterized by a late onset and was usually present even at 24 hours. A few patients complained of gastro-intestinal symptoms. It is concluded that matrix isoniazid can be given to Madras patients in doses of 30-40 mg/kg without risk of an undue incidence of immediate adverse reactions.
mesh_terms: D000328:Adult; D002986:Clinical Trials as Topic; D003692:Delayed-Action Preparations / Q000009:adverse effects; D004977:Ethambutol / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*; D014717:Vertigo / Q000139:chemically induced*
chemical_list: D003692:Delayed-Action Preparations; D004977:Ethambutol; D007538:Isoniazid