[Change in the immunoreactivity of white rats immunized with a Candida albicans vaccine during the use of antibiotics].
The experiment was carried out with 252 albino rats of Wistar line immunized with Candida albicans vaccine under conditions of treatment with tetracycline, streptomycin and penicillin in doses of 40000-50000 Units/kg body weight. In the first part of the experiment the animals were immunized with a single dose of dead carpuscular vaccine and treated with the antibiotics for 10 days. In the second part of the experiment the animals were immunized 3 times, and 2nd and 3rd immunizations being with live cultures of C. albicans and the antibiotics were used for 20 days. The results of the experimental showed that repeated administrations of the antibiotics to the albino rats during immunization decreased the animal immune reactivity and aggravated the experimental candidosis: the rate of semination with the fungus increased and excretion of the fungus from the organism decreased.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000908:Antibodies, Fungal / Q000032:analysis; D000921:Antibody-Producing Cells / Q000187:drug effects; D000937:Antigen-Antibody Reactions / Q000187:drug effects*; D002176:Candida albicans / Q000276:immunology*; D002177:Candidiasis / Q000188:drug therapy / Q000276:immunology; D002452:Cell Count; D004347:Drug Interactions; D005657:Fungal Vaccines / Q000008:administration & dosage*; D006386:Hemagglutination Tests; D007114:Immunization; D010406:Penicillins / Q000494:pharmacology; D051381:Rats; D013307:Streptomycin / Q000494:pharmacology; D013752:Tetracycline / Q000494:pharmacology; D013997:Time Factors
D000900:Anti-Bacterial Agents; D000908:Antibodies, Fungal; D005657:Fungal Vaccines; D010406:Penicillins; D013752:Tetracycline; D013307:Streptomycin
Izmenenie immunoreaktivnosti belykh krys, immunizirovannykh vaktsinoĭ Candida albicans v usloviiakh primeneniia antibiotikov