title: Muscular ventricular septal defects: a reappraisal of the anatomy.
abstract: Among 79 autopsy specimens of heart with an isolated ventricular septal defect, there were 29 cases of muscular defect. Among 60 hearts with complete transposition of the great arteries and a ventricular septal defect, there were 13 cases with a muscular defect. All muscular defects could be classified in three different types, based on the specific pathologic anatomy of the ventricular septum. The central and posterior defects were usually large and single, the marginal defects were frequently small and multiple. In hearts with transposition, central muscular defects were extremely rare, whereas these defects were by far the most frequent muscular defects in isolated ventricular septal defect. Alternatively, the posterior type was more common in cases of transposition. Marginal muscular defects were rare in both groups of malformations.
mesh_terms: D006321:Heart / Q000196:embryology; D006345:Heart Septal Defects, Ventricular / Q000150:complications / Q000196:embryology / Q000473:pathology*; D006346:Heart Septum / Q000196:embryology / Q000473:pathology; D006801:Humans; D009206:Myocardium / Q000473:pathology*; D014188:Transposition of Great Vessels / Q000150:complications / Q000196:embryology / Q000473:pathology*