title: Generic inequivalence between two brands of chloramphenicol capsule.
abstract: Generic inequivalence between two brands of chloramphenicol capsules has been investigated. Both brands complied with official standards for drug content and capsule disintegration time, and exhibited similar anti-bacterial activity when tested in vitro. A slow dissolution rate was observed with one brand which could be related to a formulation defect which might explain reported therapeutic inefficacy.
mesh_terms: D002214:Capsules / Q000032:analysis; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002701:Chloramphenicol / Q000032:analysis / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D012995:Solubility; D013810:Therapeutic Equivalency; D013997:Time Factors
chemical_list: D002214:Capsules; D002701:Chloramphenicol