Spontaneous mutation by mutagenic repair of spontaneous lesions in DNA.
Strains of yeast carrying mutations in many of the steps in pathways repairing radiation-induced damage to DNA have enhanced spontaneous mutation rates. Most strains isolated because they have enhanced spontaneous mutation carry mutations in DNA repair systems. This suggests that much spontaneous mutation arises by mutagenic repair of spontaneous lesions.
D004260:DNA Repair; D005796:Genes; D005808:Genes, Recessive; D008954:Models, Biological; D009154:Mutation; D012441:Saccharomyces cerevisiae / Q000378:metabolism