Observations on late effects in mice exposed to 400 MeV neutrons.
Life-long observations on mortality and pathology at death were carried out on groups of mice irradiated with 250 kV X-rays or exposed to a 400 MeV neutron beam, both directly and after attenuation corresponding to the maximum dose build-up region, at comparable dose-rates. Doses up to 84 rad of 400 MeV neutrons and up to 200 rad of X-rays showed no effect on the longevity of the animals, which suggest an upper limit to the r.b.e. for life-shortening of approximately 2-5. Similar conclusions were drawn from the data on all types of leukemias. For all other neoplasms, the age-specific death-rate showed a similar shortening of the latency times for groups of mice irradiated with 0-84 rad of 400 MeV direct neutrons and 0-400 rad of X-rays, also suggesting an upper limit to the r.b.e. slightly higher than that previously indicated for life-shortening. No definite effect was observed after exposure to the attenuated neutron beam at the doses used in these experiments.
D000818:Animals; D005214:Fast Neutrons; D007953:Leukemia, Radiation-Induced / Q000401:mortality; D016403:Lymphoma, Large B-Cell, Diffuse / Q000209:etiology; D008297:Male; D051379:Mice; D009381:Neoplasms, Radiation-Induced / Q000401:mortality; D009400:Nephrosclerosis / Q000209:etiology; D009502:Neutrons; D011014:Pneumonia / Q000209:etiology; D011833:Radiation Injuries, Experimental / Q000401:mortality; D013997:Time Factors; D014965:X-Rays