Mutagenicity of industrial compounds: styrene and its possible metabolite styrene oxide.
Styrene and its presumed metabolite, styrene oxide, were tested for their mutagenic effect on a forward mutation system of yeast and of Chinese hamster cells, and on a gene-conversion system of yeast. Experiments with liver microsomal preparations and host-mediated assay with yeast were also carried out. Styrene oxide was mutagenic in all test systems. Styrene was mutagenic only in the host-mediated assay.
D000225:Adenine / Q000378:metabolism; D002460:Cell Line; D004171:Diploidy; D009153:Mutagens; D011995:Recombination, Genetic / Q000187:drug effects; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D012568:Schizosaccharomyces / Q000187:drug effects; D013343:Styrenes / Q000494:pharmacology*
D009153:Mutagens; D013343:Styrenes; D000225:Adenine