title: Pathogenesis of polycythemia vera--new concepts.
abstract: Data presently available suggest that polycythemia vera is an acquired clonal disorder of the pluripotent stem cell resulting in expansion of committed stem cell pools, most prominently in the erythroid line. In vitro and in vivo studies suggest that erythropoiesis in polycythemia vera is at least partially modulated by erythropoietin.
mesh_terms: D004920:Erythropoiesis; D004921:Erythropoietin / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000502:physiology; D006801:Humans; D011087:Polycythemia Vera / Q000209:etiology*
chemical_list: D004921:Erythropoietin