[Effect of clofibrate on tissue lipase activity in rats].
Given for 20 days at a concentration of 0.3% in the diet, clofibrate lowers serum triglyceride level and causes a 48% increase of lipoprotein lipase activity in rat fat pad, after feeding. This increase does not appear in the animals on fasting. These results agree with an effect of clofibrate upon membranous adenyl-cyclase of adipose tissue.
D000067956:Adenylyl Cyclase Inhibitors; D000273:Adipose Tissue / Q000187:drug effects / Q000201:enzymology*; D000818:Animals; D002994:Clofibrate / Q000494:pharmacology*; D004032:Diet; D004789:Enzyme Activation; D005215:Fasting; D006321:Heart / Q000187:drug effects; D008049:Lipase / Q000378:metabolism*; D008053:Lipid Mobilization / Q000187:drug effects; D008071:Lipoprotein Lipase / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000201:enzymology; D051381:Rats; D014280:Triglycerides / Q000097:blood
D000067956:Adenylyl Cyclase Inhibitors; D014280:Triglycerides; D008049:Lipase; D008071:Lipoprotein Lipase; D002994:Clofibrate
Influence du clofibrate sur l'activité lipasique tissulaire chez le rat