[Clarification of cytologically doubtful findings of the cervix by DNA-single-cell-fluorescence-cytophotometry].
By using single-cell-DNS-cytophotometry in 28 single cases and 11 follow-up studies it was possible to differentiate the doubtful cytological findings and the mild and moderate dysplasia concerning the expected biological behaviour (risk of degeneration). If there are histograms similar to those with normal or inflammatory altered squamous epithelium, which are classified as "behaviour like a facultative precancerous lesion", further clinical observation is necessary. Histograms which show aneuploidy and/or wide spread to the right side are classified as "behaviour like an obligatory precancerous lesion". In these cases a conization should be performed, even if the findings are cytomorphological Pap III or mild dysplasias.
D000782:Aneuploidy; D002584:Cervix Uteri / Q000473:pathology*; D004247:DNA; D003937:Diagnosis, Differential; D005260:Female; D005453:Fluorescence; D006652:Histological Techniques; D006801:Humans; D010783:Photometry / Q000379:methods; D011123:Polyploidy; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis*; D014626:Vaginal Smears
D004247:DNA
Abklärung differentialzytologisch unklarer Zervixbenfunde durch DNS-Einzelzell-Fluoreszenz-Zytophotometrie