title: Orientation of major histocompatibility (MHC) genes relative to the centromere of human chromosome 6.
abstract: Linkage analysis of the data obtained from a three-generation Dutch family segregating for genetic variants of centromeric heterochromatic region in the band p11 on chromosome 6 (6ph), major histocompatibility (MHC) genes HLA-A, HLA-B and HLA-C, glyoxalase I (GLO) and phosphoglucomutase-3 (PGM3) showed that the genetic distance between the HLA gene cluster and 6ph is about 6 cM (at an estimated peak lod score of 3.466), that GLO is closer than HLA to the centromere and that PGM3 is probably not situated on the same chromosomal arm as HLA.
mesh_terms: D002503:Centromere / Q000648:ultrastructure*; D002875:Chromosomes / Q000648:ultrastructure*; D002906:Chromosomes, Human, 6-12 and X; D005260:Female; D008040:Genetic Linkage; D014644:Genetic Variation; D006038:Glyoxylates / Q000378:metabolism; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D008285:Major Histocompatibility Complex; D008297:Male; D010375:Pedigree; D010733:Phosphoglucomutase / Q000235:genetics
chemical_list: D006038:Glyoxylates; D006680:HLA Antigens; D010733:Phosphoglucomutase