[Role of the individual sensitivity to various cytostatic agents in children with neuroblastomas].
Primary plasmic cultures of 33 tumors of the sympathic nervous system of children (27 neuroblastomas and 6 ganglioneuromas) were used for determination of their individual sensitivity to vincristin, vinblastin, dactinomycin, mithramycin, olivomycin, cyclophosphant bruneomycin and adriamycin. Most of the tumors were sensitive to vincristin, rubomycin an adriamycin. The data obtained in vitro and in the clinic were compared with respect to 12 cases (treatment with vincristin, combination of olivomycin with cyclophosphan, vincristin with rubomycin or cyclophosphan). Coinsidence of the results was observed in 8 cases. The method of primary plasmic cultures may be successfully used for determination of individual sensitivity of children with neuroblastomas to various cytostatics.
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002648:Child; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005729:Ganglioneuroma / Q000188:drug therapy; D006801:Humans; D066298:In Vitro Techniques; D008722:Methods; D009447:Neuroblastoma / Q000188:drug therapy*
D000970:Antineoplastic Agents
O roli opredeleniia individual'noĭ chuvstvitel'nosti neĭroblastom deteĭ k razlichnym tsitostaticheskim sredstvam