title: Clinical use of immunosuppressive drugs: part I.
abstract: While immunosuppressive drugs are principally used in the treatment of malignant disease, their use in non-malignant disease and transplantation has become commonplace. The mechanisms of action of immunosuppressive agents differ. Alkylating agents react with nucleophilic centres of D, and rna. Folic acid antagonists prevnt the conversion of dihydrofolic acid to tetrahydrofolic acid. Antibiotics act in a variety of different ways; the        alkaloids cause metaphase arrest. Cytarabine (cytosine arabinoside), methotrexate, hydroxyurea and  thioguanine act during mitosis and the latter also acts during replication is not known...
mesh_terms: D016918:Arthritis, Reactive / Q000188:drug therapy; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D001528:Behcet Syndrome / Q000188:drug therapy; D003882:Dermatomyositis / Q000188:drug therapy; D014890:Granulomatosis with Polyangiitis / Q000188:drug therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy; D010392:Pemphigus / Q000188:drug therapy; D010916:Pityriasis Rubra Pilaris / Q000188:drug therapy; D011565:Psoriasis / Q000188:drug therapy; D012216:Rheumatic Diseases / Q000188:drug therapy; D012595:Scleroderma, Systemic / Q000188:drug therapy; D012859:Sjogren's Syndrome / Q000188:drug therapy
chemical_list: D007166:Immunosuppressive Agents