Penfluridol and thiothixene. Dosage, plasma levels and changes in psychopathology.
Plasma levels of penfluridol and thiothixene were studied after 4 weeks treatment in a double-blind controlled trial of 47 patients suffering from chronic schizophrenic syndromes. There was found a tenfold variation in plasma levels for penfluridol, and about a twentyfold variation for thiothixene. For penfluridol, a significant correlation between dosage and plasma level and also between dosage and changes in psychopathology as regards factor 5 in the Märtens & Jonsson S scale which comprises the items most characteristic of a schizophrenic syndrome, was found. For thiothixene, a significant correlation between plasma levels and changes in factor 5 was found. A gas-chromatographic method for penfluridol is also described.
D000328:Adult; D002849:Chromatography, Gas; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010395:Penfluridol / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D010880:Piperidines / Q000627:therapeutic use*; D012559:Schizophrenia / Q000188:drug therapy*; D013888:Thiothixene / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*
D010880:Piperidines; D010395:Penfluridol; D013888:Thiothixene