Controlled field  trials of three different oral killed typhoid vaccines in India.
Three vaccination trials against typhoid fever  were carried out in 1968/69, 1970/71 and 1974 in New Dehli. The vaccine was generally administered in tablet form  on three consecutive days. Each new trial consisted of a larger number of killed bacteria: 100.10(9), then 300.10(9) and finally 400.10(9) killed S. typhi. The placebo and vaccinated groups were composed of 6,000 to 7,000 persons, sometimes only  children from 6 to 17 years. The number of typhoid fever cases which appeared under normal conditions of infection did not show significant difference between the vaccinated and non-vaccinated subjects during the 18 month  period of observation.
D000284:Administration, Oral; D000293:Adolescent; D002648:Child; D002986:Clinical Trials as Topic; D006801:Humans; D007109:Immunity; D007194:India; D010919:Placebos; D012485:Salmonella typhi / Q000276:immunology; D013607:Tablets; D014435:Typhoid Fever / Q000453:epidemiology / Q000517:prevention & control*; D014436:Typhoid-Paratyphoid Vaccines / Q000008:administration & dosage* / Q000627:therapeutic use
D010919:Placebos; D013607:Tablets; D014436:Typhoid-Paratyphoid Vaccines