[Intensification of the bactericidal action of mitomycin C and of UV irradiation with some anthracycline antibiotics].
Anthracycline antibiotics, such as rubomycin C (rubomycin, daunomycin), rubomycin B, carminomycin and tavromycetin (cinerubin) significantly increased the bactericidal effect of ultraviolet radiation and mitomycin C with respect to mutant 19-8 of E. coli with increased permeability of the cell membrane. This may be accounted for inhibition of DNA reparation. Beromycin, an antibiotic of the same group had no such capacity. With respect to their activity the antibiotics were arranged as follows: rubomycin C, rubomycin B, carminomycin, tavromycetin.
D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D002463:Cell Membrane Permeability / Q000187:drug effects / Q000528:radiation effects; D004357:Drug Synergism / Q000528:radiation effects; D004926:Escherichia coli / Q000187:drug effects / Q000528:radiation effects; D008937:Mitomycins / Q000494:pharmacology*; D014466:Ultraviolet Rays
D000903:Antibiotics, Antineoplastic; D008937:Mitomycins
Usilenie bakteritsidnogo deĭstviia mitomitsina C i UF-oblucheniia nekotorymi antratsiklinovymi antibiotikami