The genus Cephalotaxus: source of homoharringtonine and related anticancer alkaloids.
Various phases of research on Ciphalotaxus alkaloids are summarized, including their discovery, nature of antitumor activity, isolation, structural characterization, synthesis, biogenesis, and mechanism of physiologic action.
D000470:Alkaloids / Q000302:isolation & purification*; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D004952:Esters; D006248:Harringtonines / Q000138:chemical synthesis / Q000302:isolation & purification* / Q000627:therapeutic use; D006801:Humans; D007939:Leukemia L1210 / Q000188:drug therapy; D007942:Leukemia, Experimental / Q000188:drug therapy; D007945:Leukemia, Lymphoid / Q000188:drug therapy; D013329:Structure-Activity Relationship
D000470:Alkaloids; D004952:Esters; D006248:Harringtonines