[Humoral factors in the stimulation of immunogenesis in a toxic lesion of the liver].
The work was aimed at the study of possibilities of passive transfer of the immunostimulating effect (with the aid of blood serum) observed in various pathological conditions of the liver. Investigations were carried out on rabbits poisoned with carbon tetrachloride (primary serum donors), healthy rabbits (primary recipients and secondary donors of the serum), and healthy rabbits (secondary serum recipients). Crude and heated (for 30 min at 56 degrees C) sera of rabbits poisoned with carbon tetrachloride stimulated production of antibodies induced with the antigen in the intact animals. Under the effect of trasilol, a polyvalent proteinase inhibitor, the sera of rabbits poisoned with carbon tetrachloride lost their immunostimulating properties. The sera of rabbits given injections of the sera obtained from the poisoned animals produced an immunostimulating action which failed to disappear under the effect of trasilol.
D000818:Animals; D000906:Antibodies / Q000032:analysis; D000917:Antibody Formation / Q000187:drug effects; D000941:Antigens / Q000008:administration & dosage; D007611:Aprotinin / Q000276:immunology; D002252:Carbon Tetrachloride Poisoning / Q000276:immunology; D056486:Chemical and Drug Induced Liver Injury / Q000276:immunology*; D003298:Coombs Test; D006386:Hemagglutination Tests; D006462:Hemolytic Plaque Technique; D007106:Immune Sera / Q000008:administration & dosage; D007116:Immunization, Passive; D011817:Rabbits; D013997:Time Factors
D000906:Antibodies; D000941:Antigens; D007106:Immune Sera; D007611:Aprotinin
Gumoral'nye faktory stimuliatsii immunogeneza pri toksicheskom porazhenii pecheni