Intra-amniotic urea and prostaglandin F2 alpha for midtrimester abortion: a modified regimen.
A study comparing intra-amniotic urea plus intravenous oxytocin and intra-amniotic urea with 10 mg. prostaglandin F2 alpha was completed. In addition, the results obtained with a further 150 patients receiving urea and prostaglandin are reported. Mean injection-abortion intervals ranged from 15.75 hours for urea-prostaglandin to 18.93 hours for urea-oxytocin. The advantages of urea-prostaglandin and suggested improvements are discussed. Over all, the method appears efficacious though incomplete abortions and cervical laceration are persistent problems.
D000028:Abortion, Induced / Q000009:adverse effects; D000328:Adult; D000650:Amnion; D002584:Cervix Uteri / Q000293:injuries; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D005260:Female; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D007239:Infections / Q000209:etiology; D007263:Infusions, Parenteral; D007267:Injections; D010121:Oxytocin / Q000008:administration & dosage* / Q000009:adverse effects; D010298:Parity; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011460:Prostaglandins F / Q000008:administration & dosage* / Q000009:adverse effects; D013997:Time Factors; D014508:Urea / Q000008:administration & dosage* / Q000009:adverse effects; D014839:Vomiting / Q000209:etiology
D011460:Prostaglandins F; D010121:Oxytocin; D014508:Urea