Formaldehyde induced DNA-protein crosslinks in Escherichia Coli.
Exposure of Escherichia coli to low doses of formaldehyde induces interstrand cross-links in the cellular DNA, at least 50% of which involve protein "bridges" between the DNA strands. The biological importance of these cross-links is suggested by both the high yield of formation and by the inability of some sensitive repair deficient mutants to completely remove cross-links and bound protein from the DNA during post treatment incubation.
D001426:Bacterial Proteins; D004260:DNA Repair; D004269:DNA, Bacterial; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000187:drug effects*; D005557:Formaldehyde / Q000494:pharmacology*; D009154:Mutation; D009690:Nucleic Acid Conformation / Q000187:drug effects*
D001426:Bacterial Proteins; D004269:DNA, Bacterial; D005557:Formaldehyde