The objective measurement of mental performance in cerebrovascular disease. A double-blind controlled study, using a graded-release preparation of isoxsuprine.
An automatically controlled learned task was used to assess objectively the mental performance of a number of geriatric patients with cerebrovascular disease. The effect on the performance of the patients during treatment with isoxsuprine hydrochloride in a sustained-release presentation ("Duvadilan Retard") was measured during a double-blind, placebo-controlled trial of sixteen weeks' duration. There was a significant difference in the improvement in performance between the treated and untreated groups; by the end of the trial, the treated group having statistically significantly better scores (P = 0.047 two-tailed tests).
D000368:Aged; D002561:Cerebrovascular Disorders / Q000150:complications / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D003692:Delayed-Action Preparations; D005260:Female; D006801:Humans; D007361:Intelligence Tests; D007556:Isoxsuprine / Q000627:therapeutic use*; D008297:Male; D008568:Memory / Q000187:drug effects; D001523:Mental Disorders / Q000150:complications / Q000188:drug therapy*; D008875:Middle Aged
D003692:Delayed-Action Preparations; D007556:Isoxsuprine