Cephazolin: a comparison to ampicillin in respiratory and urinary infections with dosage regulation by a nomogram.
Cephazolin sodium was shown to be as effective as ampicillin in the treatment of respiratory and urinary system infections in patients who were infected with susceptible organisms and had a much less troublesome side reaction rate of hypersensitivity type. In addition, it was found that predictable blood levels of cephazolin could be obtained in patients with renal failure when dosage was regulated according to a nomogram calculated from the patient's serum half-life based on clearance of creatinine.
D000667:Ampicillin / Q000009:adverse effects / Q000627:therapeutic use*; D002437:Cefazolin / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use*; D002511:Cephalosporins / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004342:Drug Hypersensitivity / Q000209:etiology; D004927:Escherichia coli Infections / Q000188:drug therapy; D006192:Haemophilus Infections / Q000188:drug therapy; D006207:Half-Life; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood; D007710:Klebsiella Infections / Q000188:drug therapy; D011008:Pneumococcal Infections / Q000188:drug therapy; D011512:Proteus Infections / Q000188:drug therapy; D012141:Respiratory Tract Infections / Q000188:drug therapy*; D013203:Staphylococcal Infections / Q000188:drug therapy; D014552:Urinary Tract Infections / Q000188:drug therapy*
D002511:Cephalosporins; D000667:Ampicillin; D002437:Cefazolin