Heterogeneity of stem cells in severe combined immunodeficiency.
Two patients with severe combined immunodeficiency disease (SCID) having variable B-cell development have been shown to have marrow precursors of lymphoid cells which can be induced in vitro by thymic factors to express certain T-cell surface characteristics (HTLA+ phenotypes). Their marrow cells could not, however, be induced by these same factors to develop the E-rosette marker or functional activities of T lymphocytes. The marrow of these children also showed, when compared to that of normal adults, a different distribution of cellular elements on density gradient fractionation. The findings support the view that the disorder under study has a different pathogenesis from other forms of SCID previously analysed.
D000367:Age Factors; D001402:B-Lymphocytes / Q000276:immunology; D002454:Cell Differentiation; D002462:Cell Membrane / Q000276:immunology; D006412:Hematopoietic Stem Cells / Q000276:immunology*; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000276:immunology* / Q000628:therapy; D007223:Infant; D016031:Liver Transplantation; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology; D013949:Thymus Extracts / Q000276:immunology; D013950:Thymus Gland / Q000637:transplantation; D013997:Time Factors; D014184:Transplantation, Homologous
D013949:Thymus Extracts