title: A study on the mutagenic activity of styrene and styrene oxide.
abstract: Styrene oxide is multagenic, without metabolic activation, to S. typhimurium strains TA 1535 and TA 100, which have been devised to detect mutagens causing base-pair substitutions. Styrene seems to be mutagenic toward the same strains, but only after metabolic activation. The toxicity of both styrene and styrene oxide make the construction of reliable dose-response curves rather difficult. Diethylmaleate and 3,3,3-trichloropropene oxide enhanced the mutagenicity of styrene oxide in the presence of homogenate; this result indicates the participation of epoxide hydratase and glutathione S-oxide transferase in the metabolism of styrene oxide. These two chemicals did not influence the mutagenic activity of styrene. Styrene glycol and 4-tert-butyl-brenzcatechin were not mutagenic to any of the strains studied. Results show that further, more detailed experimental and, possibly, epidemiologic studies are warranted.
mesh_terms: D000818:Animals; D004851:Epoxide Hydrolases / Q000037:antagonists & inhibitors; D005978:Glutathione / Q000037:antagonists & inhibitors; D008297:Male; D009154:Mutation / Q000187:drug effects*; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects*; D013343:Styrenes / Q000633:toxicity*
chemical_list: D013343:Styrenes; D004851:Epoxide Hydrolases; D005978:Glutathione