[Thrombocyte replacement with HL-A typed non-related single donors].
Thrombocytopenic patients who have become refractory to platelet transfusions from random donors will usually respond to HL-A compatible platelets with normal increments and hemostatic improvement. In our experience with unrelated HL-A typed donors, HL-A identity is unnecessary. Donors without excess antigen are compatible and even many donors with 1 excess antigen can be used, at any rate in immunosuppressed patients. Thus successful substitution of platelet becomes possible in refractory patients when family donors cannot be used.
D000741:Anemia, Aplastic / Q000139:chemically induced / Q000628:therapy; D001792:Blood Platelets; D001803:Blood Transfusion / Q000379:methods*; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D002701:Chloramphenicol / Q000009:adverse effects; D005260:Female; D006680:HLA Antigens; D006648:Histocompatibility; D006801:Humans; D008297:Male; D008875:Middle Aged; D010956:Plasmapheresis; D013921:Thrombocytopenia / Q000628:therapy*; D014184:Transplantation, Homologous
D006680:HLA Antigens; D002701:Chloramphenicol
Thrombozytenersatz mit HL-A-typisierten nicht-verwandten Einzelspendern