title: Rifampicin-induced protein synthesis: A pre-requisite for increased expression of the beta beta' operon in Escherichia coli.
abstract: In a rifS/rifR heterodiploid strain of E. coli, a 4 minute pulse of rifampicin can induce a prolonged (greater than 60 min) increase in the rate of synthesis of the RNA polymerase subunits, beta and beta'. The application of a constraint on the fidelity of protein synthesis during, but not after, the rifampicin pulse partially arrests the development of this capacity for subunit synthesis. I discuss the implications of these findings in relation to the control of the BB' operon in E. coli.
mesh_terms: D012321:DNA-Directed RNA Polymerases / Q000096:biosynthesis*; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology*; D009154:Mutation; D009876:Operon; D012293:Rifampin / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D012321:DNA-Directed RNA Polymerases; D012293:Rifampin