title: Cytoplasmic inheritance of antimycin A resistance in Saccharomyces cerevisiae.
abstract: Three antimycin resistant mutants of Saccharomyces cerevisiae are characterized genetically. The mutations have been shown to be cytoplasmically inherited by four criteria. The phenotype persists in diploids formed by a cross with a pO strain of yeast of the opposite mating type. Diploids heterozygous for the antimycin marker, however, show segregation of the resistance and sensitivity during mitosis. Tetrad analysis indicates a non-Mendelian segregation (4:0 and 0:4) of the mutations. The antimycin marker can be eliminated by ethidium bromide treatment under conditions that should have deleted all of the mitochondrial DNA.
mesh_terms: D000968:Antimycin A / Q000494:pharmacology*; D003433:Crosses, Genetic; D004352:Drug Resistance, Microbial; D004996:Ethidium; D005111:Extrachromosomal Inheritance; D005838:Genotype; D009154:Mutation; D010641:Phenotype; D012441:Saccharomyces cerevisiae / Q000187:drug effects*
chemical_list: D000968:Antimycin A; D004996:Ethidium