On the fungitoxicity of some new thiocyanatopyrazole derivatives: electron microscopical study in Trichophyton mentagrophytes.
Four thiocyanatopyrazole derivatives were synthesized and their fungistatic activity was demonstrated in vitro against a number of dermatophytic fungi. In Trichophyton mentagrophytes, the most active compound induced as unusual increase of the plasma membrane with production of intra and extracytoplasmic complexes, a deterioration of nuclear and mitochondrial membranes and a formation of autophagic-like vacuoles. Plasmolysis, accompanied by an almost complete disorganization of cytoplasmic structures, seemed to be the final event. A possible mechanism of action of the compounds were discussed.
D000935:Antifungal Agents; D002176:Candida albicans / Q000187:drug effects; D002462:Cell Membrane / Q000187:drug effects; D003593:Cytoplasm / Q000187:drug effects; D004821:Epidermophyton / Q000187:drug effects; D008864:Microsporum / Q000187:drug effects; D011720:Pyrazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D013861:Thiocyanates / Q000138:chemical synthesis / Q000494:pharmacology*; D014249:Trichophyton / Q000187:drug effects* / Q000648:ultrastructure
D000935:Antifungal Agents; D011720:Pyrazoles; D013861:Thiocyanates