Studies on antilipolytic activity of antipyretics. Part I. Influence of sodium salicylate, acetylsalicylic acid, phenazone, aminophenazone, and acetophenidin on lipolysis in fever induced by E. coli pyrogen.
The fever induced by E. coli pyrogen (LPS) is accompanied by a rise of FFA and glycerol level. All tested antipyretics inhibited both thermogenesis of lipolysis produced by LPS. These results suggest that the antipyretic effect of antipyretic drugs is not confined to their action on heat-dissipating mechanisms, but may also be exerted by a depression of lipid metabolism.
D000632:Aminopyrine / Q000494:pharmacology; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000983:Antipyrine / Q000494:pharmacology; D001241:Aspirin / Q000494:pharmacology; D001831:Body Temperature / Q000187:drug effects; D004926:Escherichia coli; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005334:Fever / Q000139:chemically induced / Q000378:metabolism*; D005990:Glycerol / Q000097:blood; D050356:Lipid Metabolism; D010615:Phenacetin / Q000494:pharmacology; D011749:Pyrogens / Q000494:pharmacology*; D011817:Rabbits; D012980:Sodium Salicylate / Q000494:pharmacology; D013997:Time Factors
D000700:Analgesics; D005230:Fatty Acids, Nonesterified; D011749:Pyrogens; D000632:Aminopyrine; D010615:Phenacetin; D005990:Glycerol; D001241:Aspirin; D000983:Antipyrine; D012980:Sodium Salicylate