[2alpha-Hydroxylation of 5alpha-dihydrotestosterone in the lung of guinea pigs (author's transl)].
The hydroxylation of 5alpha-dihydrotestosterone at C-2 in guinea pigs was measured with [1alpha,2alpha-T]5alpha-dihydrotestosterone as substrate by isolation of the liberated HTO ("Stoffwechsel-labile Markierung"). The hydroxylation measured in vivo by radiospirometry (condensation of body water with HTO from the expired air) was much higher in males than in females, due to the high hydroxylation capacity of the lung in males. In addition to lung, adrenal and liver showed a high, sexual organ low hydroxylation capacity for 5alpha-dihydrotestosterone.
D000311:Adrenal Glands / Q000378:metabolism; D000818:Animals; D013196:Dihydrotestosterone / Q000378:metabolism*; D005260:Female; D006168:Guinea Pigs; D006900:Hydroxylation; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000201:enzymology*; D008297:Male; D009928:Organ Specificity; D010053:Ovary / Q000378:metabolism; D011467:Prostate / Q000378:metabolism; D012737:Sex Factors; D013737:Testis / Q000378:metabolism; D014599:Uterus / Q000378:metabolism
D013196:Dihydrotestosterone
2alpha-Hydroxylierung von 5alpha-Dihydrotestosteron Bevorzugter Umsatz in der Lunge von männlichen Meerschweinchen.