Synergy in the antimicrobial action of penicillin and beta-chloro-D-alanine in vitro.
beta-Chloro-d-alanine and penicillin G acted on early and late steps, respectively, in the biosynthesis of the bacterial cell wall. In combination these compounds showed a synergistic effect on the growth of Salmonella typhimurium and of Escherichia coli in vitro.
D000409:Alanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004357:Drug Synergism; D004926:Escherichia coli / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D010400:Penicillin G / Q000494:pharmacology; D010403:Penicillin Resistance; D010406:Penicillins / Q000494:pharmacology*; D013997:Time Factors
D010406:Penicillins; D000409:Alanine; D010400:Penicillin G