[Comparative study of the antigens of Streptococcus group A. Rport I. Comparative characteristics of the immunologic activity of partially purified M-protien and the cytoplasmic protective antigen].
Experiments were conducted on mice. A study was made of the protective properties of the cytoplasmic fraction of streptococcus, group A, Type 1 and of an antigen isolated from it by sedimentation with ammonium sulfate, in comparison with M-protein partially purified by the method of Lancefield and Perlman. Cytoplasmic antigen was not inferior by immunogenicity in comparison with M-protein. In difference from the latter, it was thermolabile and sensitive to the action of hydrochloric acid. The protective antigen was revealed in the cytoplasm not only of the virulent, but also of avirulent strains of streptococcus devoid of M-protein.
D000818:Animals; D000942:Antigens, Bacterial / Q000302:isolation & purification; D005069:Evaluation Studies as Topic; D007114:Immunization; D051379:Mice; D013290:Streptococcal Infections / Q000517:prevention & control; D013297:Streptococcus pyogenes / Q000276:immunology*
D000942:Antigens, Bacterial
Sravnitel'noe izuchenie antigenov streptokokka gruppy A. Soobschenie I. Sravnitel'naia kharakteristika immunogennoĭ aktivnosti chastichno ochishchennogo M-proteina i tsitoplazmaticheskogo zashchitnogo antigena