Clinical and haemodynamic study of a new vasodilator drug L6150 (3-[bis-(2-hydroxyethyl)amino]-6-hydrazinopyridazine) in man.
1. L6150 is a highly effective vasodilator which produces an acute reduction of blood pressure when administered intravenously. 2. This is due entirely to a decrease in total peripheral vascular resistance. 3. On oral administration it can effectively lower blood pressure in mild hypertension and is effective in combination with other hypotensive agents with different mechanisms of action.
D000284:Administration, Oral; D002986:Clinical Trials as Topic; D004983:Ethanolamines / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007275:Injections, Intravenous; D011724:Pyridazines / Q000008:administration & dosage / Q000627:therapeutic use*; D014655:Vascular Resistance / Q000187:drug effects; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use*
D004983:Ethanolamines; D011724:Pyridazines; D014665:Vasodilator Agents