The effect of prednisone on the non-stimulated and the stimulated NBT test.
The non-stimulated and stimulated nitroblue tetrazolium (NBT) dye test was studied in five normal adults in sequence, viz. before and at intervals after prednisone was given as one large dose. A negative effect of prednisone on the NBT response was seen. This applied to both the non-stimulated and stimulated NBT test. For the latter five different toxins were used. At the same time a pronounced neutrophil granulocytosis was seen. The depression of the NBT test is present both in the percentage of NBT-stained neutrophils and when expressed in absolute counts of NBT-strained neutrophils.
D000328:Adult; D001424:Bacterial Infections / Q000175:diagnosis; D004926:Escherichia coli; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism; D009580:Nitroblue Tetrazolium / Q000378:metabolism; D011241:Prednisone / Q000494:pharmacology*; D012482:Salmonella paratyphi A; D013778:Tetrazolium Salts; D013997:Time Factors; D014118:Toxins, Biological / Q000494:pharmacology
D013778:Tetrazolium Salts; D014118:Toxins, Biological; D009580:Nitroblue Tetrazolium; D011241:Prednisone