[The effect of local anaesthetics on uterine blood flow and O2-consumption in non-pregnant sheep (author's transl)].
11 non-pregnant sheep were prepared for chronic studies with an electromagnetic flow transducer placed around one uterine artery and with catheters in both uterine veins, aorta and inferior vena cava. The 4 local anaesthetics bupivacaine, etidocaine, lignocaine and chloroprocaine were infused intravenously on consecutive days in a randomized manner. During the infusions of all 4 local anaesthetics, uterine blood flow decreased due to an increase of uterine vascular resistance. The uterine arteriovenous O2-difference increased, while the uterine O2-consumption decreased without development of an acidosis of the uterus. The same changes were observed in 8 animals, to which oestrone had been administered intravenously prior to the infusions of local anaesthetics. Local anaesthetics had the same effects in the non-pregnant and pregnant uterus. A direct vasoconstrictive mechanism on the uterine vessels as well as a depressing effect on metabolism is discussed for the local anaesthetics.
D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D002045:Bupivacaine / Q000494:pharmacology; D004970:Estrone / Q000494:pharmacology; D005041:Etidocaine / Q000494:pharmacology; D005260:Female; D008012:Lidocaine / Q000494:pharmacology; D010101:Oxygen Consumption / Q000187:drug effects; D011247:Pregnancy; D011343:Procaine / Q000031:analogs & derivatives / Q000494:pharmacology; D012756:Sheep; D014599:Uterus / Q000098:blood supply / Q000187:drug effects* / Q000378:metabolism; D014661:Vasoconstriction / Q000187:drug effects
D000779:Anesthetics, Local; D004970:Estrone; D011343:Procaine; C004616:chloroprocaine; D008012:Lidocaine; D005041:Etidocaine; D002045:Bupivacaine
Die Wirkung von Lokalanaesthetika auf Durchblutung und O2-Verbrauch des Uterus von nichtschwangeren Schafen.