title: Directed selective pressure on a beta-lactamase to analyse molecular changes involved in development of enzyme function.
mesh_terms: D000581:Amidohydrolases / Q000378:metabolism*; D002384:Catalysis; D002510:Cephalosporinase / Q000378:metabolism*; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000201:enzymology*; D007700:Kinetics; D009154:Mutation; D010405:Penicillinase / Q000378:metabolism*; D010957:Plasmids; D012641:Selection, Genetic; D013329:Structure-Activity Relationship
chemical_list: D000581:Amidohydrolases; D002510:Cephalosporinase; D010405:Penicillinase