[Comparative study of antineoplastic and immunosuppressive properties of ftorafur].
In experiments staged on mice with transplantable leukemia L 1210 an immunodepressive and antineoplasic action of phthorafur was studied. Depending upon its dose phthorafur lowered the number of lymphoma colonies and antibody-forming cells in the spleen of the animals immunized with sheep erythrocytes. The maximal immunodepressive action was found to set in following administration of the agent in a dose of 500 mg/kg 24 and 48 hours after antigenic stimulation.
D000818:Animals; D000921:Antibody-Producing Cells; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D002452:Cell Count; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D005472:Fluorouracil / Q000031:analogs & derivatives*; D007166:Immunosuppressive Agents; D007279:Injections, Subcutaneous; D007939:Leukemia L1210 / Q000188:drug therapy* / Q000276:immunology; D051379:Mice; D009368:Neoplasm Transplantation; D013154:Spleen / Q000473:pathology; D005641:Tegafur / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D014184:Transplantation, Homologous
D007166:Immunosuppressive Agents; D005641:Tegafur; D005472:Fluorouracil
Sravnitel'noe izuchenie protivoopukholevykh i immunodepressivnykh svoĭstv tsitostatika ftorafura.