Decrease of endothelaemia during immunosuppression.
The counts of circulating endothelial cells estimated by a new quantitative method were significantly decreased in a group of patients after renal transplantation. Subsequent animal studies have shown that such a decrease may be attained by the administration of immunosuppressive drugs. The explanation of this observation may be based on the suppression of a normal endothelial cell replacement.
D000818:Animals; D001379:Azathioprine / Q000494:pharmacology; D001772:Blood Cell Count; D001773:Blood Cells / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D003864:Depression, Chemical; D004727:Endothelium / Q000166:cytology* / Q000187:drug effects; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D016030:Kidney Transplantation; D051381:Rats; D014184:Transplantation, Homologous
D007166:Immunosuppressive Agents; D001379:Azathioprine; D006854:Hydrocortisone