Antilipolytic therapy in angina pectoris. Reduction of exercise-induced ST segment depression.
A double-blind cross-over study was performed on 12 men sith stable angina pectoris in order to determine the effect of antilipolytic treatment on exercise tolerance and exercise-induced electrocardiographic changes. The men were exercised to the onset of anginal pain using a reproducible and standardized ergometric load. A nicotinic acid analogue was used to reduce plasma free fatty acids and free glycerol before and during exercise testing and to eliminate their post-exercise rise. This was associated with significant reduction of exercise-induced ST segment depression (p less than 0-005), though there was no significant difference in the duration of exercise before the oneset of pain. A change in the prportions of lipid and carbohydrate for oxidation by the ischaemic myocardium, making relatively more glucose available, is a likely explanation.
D000368:Aged; D000787:Angina Pectoris / Q000097:blood / Q000188:drug therapy*; D001794:Blood Pressure; D002986:Clinical Trials as Topic; D005080:Exercise Test; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005990:Glycerol / Q000097:blood; D006339:Heart Rate; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009539:Nicotinic Acids / Q000627:therapeutic use*; D010919:Placebos
D005230:Fatty Acids, Nonesterified; D000960:Hypolipidemic Agents; D009539:Nicotinic Acids; D010919:Placebos; D005990:Glycerol