Pathogenesis of trypan-blue-induced spina bifida.
Congenital malformations induced in rats by the application of trypan blue were studied at variable times of their development of congenital malformations is a continuous process of structural and functional adaptation of the development embryo to focal tissue degeneration and necrosis (cell death). The primary degeneration is a transitory phenomenon, because the dead cells are phagocytosed by surviving cells. However, the damage triggers off the process of abnormal development.
D000818:Animals; D002470:Cell Survival; D004475:Ectoderm / Q000473:pathology; D005260:Female; D011247:Pregnancy; D051381:Rats; D016135:Spinal Dysraphism / Q000139:chemically induced / Q000196:embryology* / Q000473:pathology; D013997:Time Factors; D014343:Trypan Blue / Q000009:adverse effects*
D014343:Trypan Blue