[Role of the endocrine function of the islands of Langerhans in the mechanism of development of hypothalamic obesity].
Administration of alloxan to rats which developed hypothalamic adiposity damaged the pancreatic beta-cells and reduced the insulin secretion, thus arresting further weight gain despite some excess in food ingestion. A conclusion was drawn that in injury of the ventro-medial nuclei of the hypothalamus the most significant mechanism of obesity development was insulin hypersecretion induced by this action.
D000496:Alloxan / Q000494:pharmacology; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology; D002149:Energy Intake; D005260:Female; D007031:Hypothalamus; D007328:Insulin / Q000378:metabolism; D007329:Insulin Antagonists; D007515:Islets of Langerhans / Q000378:metabolism*; D009765:Obesity / Q000209:etiology* / Q000517:prevention & control; D010286:Paraventricular Hypothalamic Nucleus / Q000601:surgery; D051381:Rats
D001786:Blood Glucose; D007328:Insulin; D007329:Insulin Antagonists; D000496:Alloxan
O roli inkretornoĭ funktsii pankreaticheskikh ostrovkov v mekhanizme razvitiia gipotalamicheskogo ozhireniia.