Effect of organ preservation in cadaver kidney transplantation.
Hypothermic pulsatile perfusion did not adversely affect long-term renal allotransplant function and did not result in an increased rate of rejection. Thus, we can conclude that perfusion had little effect on the immunogenicity of renal allografts. The incidence of acute tubular necrosis was directly related to the length of warm ischaemia and perfusion time. However, long-term renal function was not influenced by acute tubular necrosis. Perfusion is a safe and reliable way of preserving cadaver donor kidneys until transplantation.
D002102:Cadaver; D006084:Graft Rejection / Q000401:mortality; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D016030:Kidney Transplantation; D007683:Kidney Tubular Necrosis, Acute / Q000209:etiology; D008875:Middle Aged; D009926:Organ Preservation; D010477:Perfusion; D014021:Tissue Preservation; D014184:Transplantation, Homologous