Paroxysmal nocturanal hemoglobinuria and marrow failure treated by infusion of marrow from an identical twin.
An 18-year-old white Canadian male patient with paroxysmal nocturnal hemoglobinuria and refractory marrow failure received a marrow infusion from his normal identical twin brother without prior ablation of the patient's marrow by drugs or irradiation. After 2 years of follow-up, the patient is well with no evidence of clinical disease or significant hematological abnormality. The results suggest that normal marrow stem cells can have a selective advantage over the abnormal paroxysmall nocturnal hemoglobinuria clone.
D000293:Adolescent; D001854:Bone Marrow Cells; D001855:Bone Marrow Diseases / Q000150:complications / Q000628:therapy*; D016026:Bone Marrow Transplantation; D005260:Female; D006457:Hemoglobinuria, Paroxysmal / Q000150:complications / Q000628:therapy*; D006801:Humans; D008297:Male; D011247:Pregnancy; D014184:Transplantation, Homologous; D014430:Twins, Monozygotic