Evolutionary and developmental aspects of T-cell recognition.
Studies relating to the nature of the antigen-specific T-cell receptor are reviewed in the light of present knowledge of phylogenetic and ontogenetic development. It is suggested that this evidence supports the concept that immunoglobulin (Ig) is the T-cell receptor, and that the following conclusions may be tentatively drawn.
D000375:Aging; D000663:Amphibians; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D001666:Binding Sites, Antibody; D005075:Biological Evolution; D002645:Chickens; D004626:Embryology; D005399:Fishes; D006801:Humans; D051379:Mice; D010802:Phylogeny; D011947:Receptors, Antigen, B-Cell / Q000032:analysis; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000166:cytology
D011947:Receptors, Antigen, B-Cell