title: The incorrect use of Chi-square analysis for paired data.
abstract: When results are classified in categories (for example, improved and unimproved, reactive and non-reactive) and the same patients are examined by two different treatments or two different tests, then the correct statistical analysis is by McNemars test. More often a Chi-square analysis is used; this is not only incorrect but also leads to erroneous conclusions.
mesh_terms: D006801:Humans; D007158:Immunologic Techniques; D013223:Statistics as Topic