[Treatment of thyrotoxicosis with 125-iodine: results in 93 patients 3 to 5 years after treatment, and comparison with 131-iodine therapy (author's transl)].
93 patients were treated with 125-iodine for thyrotoxicosis with a small thyroid (less than or equal to 60 gr) and without palpable nodules in the years 1972--1974. The patients were assayed by: clinical examination, radioiodine-three-phase-study and assay of hormones in the serum: thyroxine, triiodothyronine, triiodothyronine-resin-uptake and thyrotropine. The dosage was individually calculated according to the radioiodine uptake, the thyroid weight and the effective half life time of the radioiodine in the thyroid. In 60 patients the thyrotoxicosis was controlled by a single application, and in further four patients two applications eliminated the thyrotoxicosis. Two out of fifty patients with a follow up between 4 and 5 years are hypothyroid. Compared to 131-iodine therapy in a similar group, the incidence of hypothyroidism is lower after 125-iodine treatment. Only long term follow up will show, whether this advantage of 125-iodine in a very selected group of thyrotoxic patients remains. These results have encouraged us to proceed with this trial.
D005500:Follow-Up Studies; D006801:Humans; D006980:Hyperthyroidism / Q000532:radiotherapy*; D007037:Hypothyroidism / Q000209:etiology; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D011878:Radiotherapy / Q000009:adverse effects; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D007457:Iodine Radioisotopes; D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine
Therapie der Hyperthyreose mit 125-Jod: Erfahrungen bei 93 Patienten 3--5 Jahre nach Behandlung und Vergleich mit 131-Jod Therapie.