title: [Report of a controlled clinical trial of a new synthetic drug, parsalmide, in rheumatic arthropathies (inflammatory and degenerative)].
abstract: The anti-inflammatory, analgesic and tranquillizing activity of a synthetic compound called parsalmide was investigated in patients suffering from inflammatory and degenerative rheumatic arthropathies. The study was carried out in 30 subjects using the controlled experiment technique according to the "between patient" pattern, attributing parsalmide and indomethacin at random to two groups. Both preparations were found to possess good anti-inflammatory and analgesic action, comparable clinically and statistically. Tolerance was very good, particularly at gastroenteric level (no side and/or undesired effects were observed) and at the level of haemopoietic, renal and hepatic function.
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D001549:Benzamides / Q000009:adverse effects / Q000627:therapeutic use*; D001773:Blood Cells / Q000187:drug effects; D002986:Clinical Trials as Topic; D004064:Digestive System / Q000187:drug effects; D004341:Drug Evaluation; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use; D007592:Joint Diseases / Q000188:drug therapy*; D010003:Osteoarthritis / Q000188:drug therapy
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001549:Benzamides; D007213:Indomethacin
vernacular_title: Relazione sulla sperimentazione clinica controllata di una nuova sostanza di sintesi, parsalmide nelle artropatie reumatiche (infiammatorie e degenerative)