Insulin-dependent diabetes: a disease of autoaggression.
Lymphocytes from patients with insulin-dependent diabetes demonstrated significant cytoadherence and cytotoxicity against human insulinoma cells in vitro as compared to lymphocytes from normals. Complement was not involved in insulinoma cell destruction. The findings suggest that insulin-dependent diabetes may be a disease of autoaggression.
D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000276:immunology*; D002648:Child; D003601:Cytotoxicity Tests, Immunologic; D003920:Diabetes Mellitus / Q000276:immunology*; D006801:Humans; D007104:Immune Adherence Reaction; D007111:Immunity, Cellular; D007515:Islets of Langerhans / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology
D001323:Autoantibodies