[Profile comment on clinical and experimental studies of pramiverine and pramiverine/metamizole (author's transl)].
The profile of the spasmolytic 4,4-diphenyl-N-isopropyl-cyclohexylamine-hydrochloride (pramiverine, Sistalgin) is outlined on the basis of fundamental research. Evidence is provided that a combination with metamizole is useful in the case of Sistalgin comp. Description of the clinical and clinico-experimental examinations confirmed the margin of indications for Sistalgin and Sistalgin comp. Reference is made to the applications with a view to facilitate endoscopic and radiological procedures. The tabulated list of 2368 patients demonstrates the positive ratio between therapeutic effect and undesirable cholinolytic concomitant effect of Sistalgin comp.
D000818:Animals; D001559:Benzhydryl Compounds / Q000378:metabolism / Q000627:therapeutic use; D001659:Biliary Tract / Q000187:drug effects; D002986:Clinical Trials as Topic; D003085:Colic / Q000188:drug therapy; D003514:Cyclohexylamines / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D004177:Dipyrone / Q000494:pharmacology; D004338:Drug Combinations; D004724:Endoscopy; D005750:Gastric Juice / Q000378:metabolism; D005769:Gastrointestinal Motility / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007700:Kinetics; D008862:Microsomes, Liver / Q000378:metabolism; D009130:Muscle, Smooth / Q000187:drug effects; D010276:Parasympatholytics / Q000378:metabolism; D011292:Premedication; D051381:Rats; D014551:Urinary Tract / Q000187:drug effects
D001559:Benzhydryl Compounds; D003514:Cyclohexylamines; D004338:Drug Combinations; D010276:Parasympatholytics; D004177:Dipyrone
Zusammenfassung der Ergebnisse klinischer und experimenteller Untersuchungen mit Pramiverin und Pramiverin/Metamizol