title: Haloperidol-induced comatose state with hyperthermia and rigidity in adolescence: two case reports with a literature review.
abstract: Two adolescents who developed severe extrapyramidal and hypothalamic reactions due to haloperidol therapy are describe. This is a rarely reported result of utilizing this medication in children and youth, and caution is urged in its use. Prolonged reactions have occurred.
mesh_terms: D000293:Adolescent; D002648:Child; D002653:Child Behavior Disorders / Q000188:drug therapy; D003128:Coma / Q000139:chemically induced* / Q000188:drug therapy; D005260:Female; D005334:Fever / Q000139:chemically induced* / Q000188:drug therapy; D006220:Haloperidol / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009127:Muscle Rigidity / Q000139:chemically induced* / Q000188:drug therapy; D012561:Schizophrenia, Childhood / Q000188:drug therapy; D014282:Trihexyphenidyl / Q000627:therapeutic use
chemical_list: D014282:Trihexyphenidyl; D006220:Haloperidol