Inhibition by nalidixic acid of post-uv survival of Escherichia coli.
Nalidixate inhibited the post-uv survival of E. coli B. TAU-bar and Ts-7, but not Bs-1 or B/r when included in the plating medium. Removal of the drug sensitivity by photoreactivation was consistent with pyrimidine dimers as the target for the effect. Nalidixate did not inhibit liquid-holding recovery from uv when included in the holding medium, but survival was inhibited if the drug was in the subsequent plating medium. In fact, there was an actual increase in the number of nonsurvivors due to the drug following a period of holding.
D004260:DNA Repair / Q000187:drug effects*; D004255:Deoxyribodipyrimidine Photo-Lyase / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology / Q000528:radiation effects*; D009268:Nalidixic Acid / Q000494:pharmacology*; D011830:Radiation Effects; D013997:Time Factors; D014466:Ultraviolet Rays
D009268:Nalidixic Acid; D004255:Deoxyribodipyrimidine Photo-Lyase