title: The genus Cephalotaxus: source of homoharringtonine and related anticancer alkaloids.
abstract: Various phases of research on Ciphalotaxus alkaloids are summarized, including their discovery, nature of antitumor activity, isolation, structural characterization, synthesis, biogenesis, and mechanism of physiologic action.
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification*; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D004952:Esters; D006248:Harringtonines / Q000138:chemical synthesis / Q000302:isolation & purification* / Q000627:therapeutic use; D006801:Humans; D007939:Leukemia L1210 / Q000188:drug therapy; D007942:Leukemia, Experimental / Q000188:drug therapy; D007945:Leukemia, Lymphoid / Q000188:drug therapy; D013329:Structure-Activity Relationship
chemical_list: D000470:Alkaloids; D004952:Esters; D006248:Harringtonines