Safety of the bolus administration of gentamicin.
A study was done to assess the safety of gentamicin administration by a bolus method. A total of 63 patients were randomly treated with intravenous gentamicin by bolus administration (3 to 5 min) and by slow infusion (2 h). Serum gentamicin levels were measured. Renal and audiovestibular function were monitored. Pure-tone audiometry was performed at the beginning, on day 3, and at the end of therapy. The study revealed that the bolus administration was safe and nontoxic.
D000328:Adult; D000368:Aged; D001681:Biological Assay; D002986:Clinical Trials as Topic; D004926:Escherichia coli / Q000201:enzymology; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014724:Vestibular Function Tests
D005839:Gentamicins