[Enteral immunization with attenuated representatives of the family Enterobacteriaceae. Report 3. Comparison of the immunogenicity of the Sm-d-mutants of E. coli and the killed vaccine].
The authors present the results of a comparative study of the immunogenicity of the living (Sm-d) and killed E. coli vaccine which, in determination by such methods as the Vidal test, passive hemagglutination test, bactericidal activity, establishment of passive and active defence, proved to be the same in both vaccines. However, with the aid of Rauss and Ketyi's method, modified by the authors (determination of nonsuceptibility in enteral infection of the animals with intestine sterilized with streptomycin) it was possible to reveal the capacity of the living vaccine to depress the growth and the activity (reproducible and statistically controlled) of E. coli administered into the organism of the immunized animal for the purpose of infection. They were discharged with the feces for a definite period in 90% of control animals and mice immunized with the killed vaccine; this occured in less than 10% of the animals immunized with the living vaccine.
D000818:Animals; D001428:Bacterial Vaccines / Q000592:standards*; D004927:Escherichia coli Infections / Q000517:prevention & control*; D005069:Evaluation Studies as Topic; D008722:Methods; D051379:Mice; D014613:Vaccines, Attenuated / Q000592:standards*
D001428:Bacterial Vaccines; D014613:Vaccines, Attenuated
K probleme ĕnteral'noĭ immunizatsii attenuirovannymi predstaviteliami semeĭstva Enterobacteriaceae. Soobshchenie 3. Sravnenie immunogennosti Sm-d-mutantov E. coli i ubitoĭ vaktsiny