Bacterial growth inhibition by amniotic fluid. VI. Evidence for a zinc-peptide antibacterial system.
The zinc bacterial inhibitory activity of amniotic fluid is dependent on the presence of a second, organic component contained in amniotic fluid. The second component is heat stable, resists proteolytic digestion, and is present in amniotic fluid throughout pregnancy. Further, the component may be a peptide with a molecular weight of less than 5,000 daltons. Phosphate reversal of amniotic fluid inhibitory activity may result from interference with the organic component rather than zinc.
D000653:Amniotic Fluid / Q000032:analysis*; D001681:Biological Assay; D004926:Escherichia coli / Q000187:drug effects*; D005260:Female; D006801:Humans; D010455:Peptides / Q000032:analysis* / Q000494:pharmacology; D010710:Phosphates / Q000494:pharmacology; D011247:Pregnancy; D015032:Zinc / Q000494:pharmacology*
D010455:Peptides; D010710:Phosphates; D015032:Zinc