title: [Minimal cardiac transit times in the diagnosis of heart disease: measurements with the gamma retina V and indium-113m. The influence on central volume relationships of long-term digitalis therapy in patients with latent and manifest coronary insufficiency].
abstract: Using Indium-113m and the Gamma Retina V (Fucks-Knipping Camera), the minimal cardiac transit times (MTTs) were measured radiocardiographically from the right auricle to the aortic root. This analysis served to determine the relation between stroke volume and the segment volume of the part of circulation between the right auricle and the aortic root. In 39 patients with myocardial insufficiency of different clinical degree the effectiveness of digitalization was, up to a period of 5 years, measured by means of the volume relation mentioned above. The following conclusions can be drawn from the results: digitalization of patients with myocardial insufficiency leads to an improvement of the impaired relation of central volumes. In patients with diminished cardiac reserve the improvement is drastic and often results in a nearly complete normalization. The data remain constant during therapy even for an observation period of 5 years. Digitalization of patients with congestive heart failure only leads to a partial improvement. In contrast to patients with diminished cardiac reserve this effect is temporary. The different behaviour of the relation between stroke volume and segment volume in patients with diminished cardiac reserve and congestive heart failure under prolonged administration of digitalis points to the necessity of treatment with digitalis in the early stage of myocardial disease.
mesh_terms: D000328:Adult; D000368:Aged; D002302:Cardiac Output / Q000187:drug effects; D002306:Cardiac Volume / Q000187:drug effects*; D003327:Coronary Disease / Q000188:drug therapy / Q000503:physiopathology*; D004077:Digoxin / Q000494:pharmacology*; D006333:Heart Failure / Q000503:physiopathology; D006801:Humans; D008875:Middle Aged; D011865:Radioisotope Dilution Technique; D013997:Time Factors
chemical_list: D004077:Digoxin
vernacular_title: Minimale kardiale Transitzeiten in der Herzdiagnostik: Messungen mit der Gamma-Retina V und Indium-113m. Beeinflussung zentraler Volumenrelationen durch eine langjährige Digitalis-Therapie bei Patienten mit latenter und manifester Herzinsuffizienz