The pharmacology and pharmacokinetics of azapropazone - a review.
The pharmacology and pharmacokinetic properties of azapropazone, a new anti-inflammatory analgesic, are reviewed. Anti-inflammatory activity was assessed by standard in vivo and in vitro methods. The drug was shown to have definite activity with a potency approximately half that of phenylbutazone. Azapropazone was absorbed from the gastro-intestinal tract in animals and man, although wide inter-species variation in pharmacokinetic properties was noted. In man, the biological half life was approximately 20 hours. Azapropazone is not extensively metabolised and most metabolites have been identified and assayed.
D000818:Animals; D001032:Apazone / Q000097:blood / Q000378:metabolism / Q000494:pharmacology*; D001168:Arthritis / Q000188:drug therapy; D004195:Disease Models, Animal; D004285:Dogs; D006168:Guinea Pigs; D006207:Half-Life; D006801:Humans; D066298:In Vitro Techniques; D007249:Inflammation / Q000188:drug therapy; D007700:Kinetics; D011817:Rabbits; D051381:Rats; D014227:Triazines / Q000494:pharmacology*
D014227:Triazines; D001032:Apazone