The effects of the fenoterol hydrobromide (Partusisten) aerosol on uterine activity and the cardiovascular system.
Fenoterol hydrobromide (Partusisten) aerosol was used in a placebo-controlled, double-blind, double crossover trial to study its effects on oxytocin-induced uterine contractions and the maternal cardiovascular system. The active and placebo aerosols were each administered a total of ten times or twice each in five patients who were in established oxytocin-induced labour with intact membranes. Five puffs, of 200 mug each, of the active aerosol reduced uterine activity by more than half; the effect on the cardiovascular system was to cause a mild tachycardia and to widen the pulse pressure.
D000336:Aerosols; D002986:Clinical Trials as Topic; D004983:Ethanolamines / Q000494:pharmacology*; D005260:Female; D005280:Fenoterol / Q000008:administration & dosage / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D011247:Pregnancy; D011674:Pulse / Q000187:drug effects; D013268:Stimulation, Chemical; D014590:Uterine Contraction / Q000187:drug effects*
D000336:Aerosols; D004983:Ethanolamines; D005280:Fenoterol