[Improved interpretation of renal-vein-renin-ratio by simultaneous determination of renal 131I-hippuric-acid-clearance-ratio in patients with renovascular hypertension (author's transl)].
In patients with unilateral vascular kidney disease and hypertension, ratio of renal-vein-renin was compared with 131I-Hippuric-acid clearance and change in blood pressure during Saralasininfusion. The ratio of renal-vein-renin was positively correlated with the ratio in renal plasma flow between the kidneys in all patients studied. The ratio of renins therefore is a result of two factors: The difference in renin secretion and the difference in blood flow in the two kidneys. In patients with angiotensin independent hypertension renin-ratios up to 2.0 were found without relevance to elevated blood pressure. When the difference in renal blood flow between both kidneys was small, even a slight difference in renal vein renin indicated hypertension related to increased renin secretion. Renin-ratios in the critical range between 1.5 and 2.5 should only be interpreted in respect to a similar ratio in renal blood flow.
D000328:Adult; D000368:Aged; D001794:Blood Pressure; D005260:Female; D006626:Hippurates; D006801:Humans; D006977:Hypertension, Renal / Q000175:diagnosis*; D007457:Iodine Radioisotopes; D007668:Kidney / Q000098:blood supply; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D012039:Regional Blood Flow; D012083:Renin / Q000378:metabolism*; D012504:Saralasin
D006626:Hippurates; D007457:Iodine Radioisotopes; D012083:Renin; D012504:Saralasin
Verbesserte Aussage des Nierenvenenreninquotienten durch gleichzeitige Bestimmung der 131Jod-Hippuran-Clearance in der Diagnostik der renovaskulären Hypertonie.