Antimalarials. 3. 1,2,4-Triazines.
The syntheses of a number of substituted 1,2,4-triazines as potential antimalarials are described. The structural requirements for antimalarial activity are discussed with reference to the substituents of a phenyl group in the 6 position and amino groups at the 3 and 5 positions. Of the compounds tested, 2,5, and 7 produced cures in mice infected with plasmodium berghei. Compounds 2(3,5-diamino-6-(4-trifluoromethylphenyl)-1,2,4-triazine),3,5,8,12,and 37 produced cures in chicks infected with Plasmodium gallinaceum.
D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000627:therapeutic use; D002645:Chickens; D008288:Malaria / Q000188:drug therapy; D008289:Malaria, Avian / Q000188:drug therapy; D051379:Mice; D010962:Plasmodium berghei; D013329:Structure-Activity Relationship; D014227:Triazines / Q000138:chemical synthesis* / Q000627:therapeutic use
D000962:Antimalarials; D014227:Triazines