title: Prognostic value of mouse red cell rosette formation in chronic lymphocytic leukaemia.
abstract: Mouse red cell (MRC) rosette formation was studied in 20 malignant haemopathies. Only cells from chronic lymphocytic leukaemia (CLL) and hairy cell leukaemia (HCL) formed MRC rosettes with a high frequency. However, cells from 2 cases of CLL could not be demonstrated to form MRC rosettes, although they were undoubtedly found to be of B origin. These 2 cases presented as typical CLL, but they were observed to transform into a sarcomatous type after 5-6 months of evolution, suggesting that the study of MRC rosette formation might be of prognostic value in CLL.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002675:Child, Preschool; D006801:Humans; D007158:Immunologic Techniques; D007945:Leukemia, Lymphoid / Q000175:diagnosis* / Q000276:immunology; D008875:Middle Aged; D011379:Prognosis