[Increase of brain serotonin and its metabolite in rats caused by meclofenoxate].
Influence of meclofenoxate (MF) on the 5-HT and 5-HIAA contents in the cortex, diencephalon and brain stem of the rat was studied with the following results. MF caused a dose-dependent elevation of 5-HIAA level in the three different brain regions and particularly in the brain stem. An increase of 5-HT was also noted in the brain stem, whereas 5-HT in the diencephalon tended to decrease. The increase of 5-HT after pargyline was accelerated and the pargyline-induced decrease of 5-HIAA was equally inhibited by MF and probenecid, which suggests that MF blocks the efflux of 5-HIAA from the brain. The effects of MF on the brain 5-HT and 5-HIAA contents were identical with those of its hydrolysate, p-chlorophenoxyacetic acid.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism; D004027:Diencephalon / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005260:Female; D006016:Glycolates / Q000494:pharmacology*; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008297:Male; D002504:Meclofenoxate / Q000008:administration & dosage / Q000494:pharmacology*; D008636:Mesencephalon / Q000378:metabolism; D011339:Probenecid / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D013268:Stimulation, Chemical
D006016:Glycolates; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D002504:Meclofenoxate; D011339:Probenecid