Ex vivo intra-arterial infusion of microencapsulated mitomycin C into dog kidney.
Microencapsulated Mitomycin C with ethylcellulose was infused into isolated dog kidneys through the renal artery. The capsules were lodged mainly at cortico-medullary junction, where the drug was released from the capsules. Vascularity of kidney was reduced moderately.
D000818:Animals; D002214:Capsules; D003692:Delayed-Action Preparations; D004285:Dogs; D066298:In Vitro Techniques; D007261:Infusions, Intra-Arterial; D007668:Kidney / Q000378:metabolism*; D008937:Mitomycins / Q000008:administration & dosage*
D002214:Capsules; D003692:Delayed-Action Preparations; D008937:Mitomycins