Mucociliary clearance in the canine lung during and after general anesthesia.
Central and peripheral pulmonary mucociliary clearance was assessed by tantalum bronchography and serial chest roentgenograms in dogs. Thiopental, 25 mg/kg, did not change clearance from awake values. Halothane 1.2 MAC, for six hours, delayed both central and peripheral clearance by at least three hours. After halothane or diethyl ether, 1.2 MAC, for two hours, recovery of mucociliary clearance was delayed for approximately three and a half hours
D000768:Anesthesia, General; D000769:Anesthesia, Inhalation; D000771:Anesthesia, Intravenous; D000818:Animals; D001980:Bronchi / Q000187:drug effects*; D001995:Bronchography; D002923:Cilia / Q000187:drug effects*; D004285:Dogs; D004986:Ether / Q000633:toxicity*; D005019:Ethyl Ethers / Q000633:toxicity*; D006221:Halothane / Q000633:toxicity*; D013635:Tantalum; D013874:Thiopental / Q000008:administration & dosage / Q000633:toxicity*; D013997:Time Factors; D014132:Trachea / Q000187:drug effects*
D005019:Ethyl Ethers; D004986:Ether; D013635:Tantalum; D013874:Thiopental; D006221:Halothane