The nature and distribution of serologically detectable alloantigens on the preimplantation mouse embryo.
The nature and distribution of surface alloantigens on preimplantation mouse embryos has been examined by immunofluorescence. Non-H-2 alloantigens were detected at all stages examined, from the 2-cell to the 4 1/2-day blastocyst. Cleaving blastomeres, inner cell mass cells and cells of the primary trophectoderm were all positive. In F1 embryos maternal non-H-2 alloantigens were detectable at all stages, whereas paternal antigens first became evident at the 6- to 8-cell stage. No convincing evidence of the presence of alloantigens associated with the H-2 haplotype was found at any stage or on any cell type, suggesting that if these antigens are present they are in low quantity or are masked.
D000818:Animals; D001755:Blastocyst / Q000276:immunology*; D010064:Embryo Implantation; D004622:Embryo, Mammalian / Q000276:immunology*; D005260:Female; D005455:Fluorescent Antibody Technique; D006579:Heterozygote; D006720:Homozygote; D007519:Isoantigens / Q000032:analysis*; D051379:Mice; D014327:Trophoblasts / Q000276:immunology
D007519:Isoantigens