title: A comparative study of daily and twice-weekly continuation regimens of tuberculosis chemotherapy, including a comparison of two durations of sanatorium treatment.
abstract: Further results are presented of a controlled clinical trial carried out in Czechoslovakia of chemotherapeutic regimens in pulmonary tuberculosis in which, following 3 months of standard triple chemotherapy, 3 continuation regimens allocated at random for up to 18 or 24 months were compared. These were PAS plus isoniazid daily, streptomycin plus isoniazid twice a week and streptomycin plus isoniazid twice a week up to 1 year and then streptomycin plus isoniazid once a week. After 3 years the results of all 3 continuation regimens were highly satisfactory and it was concluded that they were equally effective, but that the intermittent regimens have the advantage of stricter control over the patient's chemotherapy.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D000995:Antitubercular Agents / Q000008:administration & dosage*; D002986:Clinical Trials as Topic; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005500:Follow-Up Studies; D006801:Humans; D007538:Isoniazid / Q000627:therapeutic use; D008875:Middle Aged; D013307:Streptomycin / Q000627:therapeutic use; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents; D007538:Isoniazid; D013307:Streptomycin