Effect of caffeine on the rho- -induction with ethidium bromide in Saccharomyces cerevisiae.
It is shown that caffeine antagonizes petite-induction with ethidium bromide under non-growth conditions when administered during or after mutagenic treatment. Caffeine itself is shown to be a petite-inducing agent when cells are grown in liquid glucose-complete-medium in the presence of the drug. A possible mode of action of caffeine in the ethidium bromide induced petite-mutagenesis is discussed.
D002110:Caffeine / Q000494:pharmacology*; D004996:Ethidium / Q000037:antagonists & inhibitors*; D009154:Mutation; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000254:growth & development
D002110:Caffeine; D004996:Ethidium