title: [Biophysical study on the effect of fluorine on calcified tissues].
abstract: The effects of ingestion of fluoride on the mineral substance of animal and human bones were studied. The topographical distribution at the microscopic level, and the Ca/P ratio in areas with high and low concentration of fluoride were analyzed by means of electron probe X-ray microanalysis; the crystallographic modification of bone mineral substance was evaluated by X-ray diffraction. The distribution pattern of fluoride was found to be related to bone remodeling, and the Ca/P ratio value tends to increase as a function of the fluoride content of the bone tissue. X-ray diffraction analysis shows a shortening of the a parameter of the bone apatite unit cell as a function of the fluoride content, which indicates the incorporation of fluoride in the crystalline network.
mesh_terms: D000818:Animals; D001031:Apatites; D001842:Bone and Bones / Q000032:analysis / Q000187:drug effects*; D002118:Calcium / Q000032:analysis; D003460:Crystallization; D005459:Fluorides / Q000494:pharmacology* / Q000627:therapeutic use; D009050:Fluorosis, Dental / Q000209:etiology / Q000473:pathology; D006801:Humans; D051379:Mice; D010024:Osteoporosis / Q000188:drug therapy; D010758:Phosphorus / Q000032:analysis
chemical_list: D001031:Apatites; D010758:Phosphorus; D005459:Fluorides; D002118:Calcium
vernacular_title: Etude biophysique de l'effet du fluor sur les tissus calcifiés