title: [Microtubule inhibitors].
abstract: This lecture is divided into 3 parts. The first one is a general survey of mitoclasic agents with a review of the main categories and a summary of the conclusions obtained from a comparative study of the antimitotic properties of various compounds on animal cells and plant cells. The second part describes the results of personal ultrastructural studies carried out on plant cells. They include researches on the normal behavior of microtubules in the cells and an analysis of various kinds of inhibition. The last part deals with the action mechanism of mitoclasic compounds, especially colchicine.
mesh_terms: D000470:Alkaloids / Q000494:pharmacology; D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology; D003078:Colchicine / Q000494:pharmacology; D003513:Cycloheximide / Q000494:pharmacology; D003864:Depression, Chemical; D006118:Griseofulvin / Q000494:pharmacology; D006493:Heparin / Q000494:pharmacology; D066298:In Vitro Techniques; D008670:Metals / Q000494:pharmacology; D008870:Microtubules / Q000187:drug effects* / Q000648:ultrastructure; D008938:Mitosis / Q000187:drug effects*; D009942:Organometallic Compounds / Q000494:pharmacology; D063245:Plant Development; D010944:Plants / Q000648:ultrastructure; D011033:Podophyllin / Q000494:pharmacology
chemical_list: D000470:Alkaloids; D000925:Anticoagulants; D008670:Metals; D009942:Organometallic Compounds; D006118:Griseofulvin; D011033:Podophyllin; D006493:Heparin; D003513:Cycloheximide; D003078:Colchicine
vernacular_title: Recherches sur les inhibiteurs microtubulaires