[Optimation and simplification of clinical tumor cytodiagnosis by means of cytocentrifugation].
Since the introduction of cytocentrifugation, the methods of clinical cytology have become more refined. The following advantages should be stressed: 1. speed and ease of processing, 2. highest possible cellular yield, 3. good preservation of cellular characteristics. In the light of predominantly CSF analyses in the field of pediatric oncology the above mentioned findings are clearly illustrated (ALL, AML, reticulum cell sarcomatosis, Ewing sarcoma, leptomeninx sarcoma, retinoblastoma, Letterer-Siwe's disease, familial erythrophagocytic lymphohistiocytosis, plexus papilloma). Malignancies are clearly distinguishable from benign conditions (toxic glial reactions, virus meningitides, CNS hemorrhages etc.). The higher cellular yield permits very early diagnosis of meningeal leukemia. This qualitative improvement of cytological diagnostic methods may considerably influence the choice of therapeutic procedures in the treatment of malignancies.
D002498:Centrifugation / Q000379:methods; D002648:Child; D002675:Child, Preschool; D003951:Diagnostic Errors; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis; D006801:Humans; D007945:Leukemia, Lymphoid / Q000175:diagnosis; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis; D008297:Male; D008722:Methods; D009369:Neoplasms / Q000175:diagnosis*; D012175:Retinoblastoma / Q000175:diagnosis; D012512:Sarcoma, Ewing / Q000175:diagnosis
Optimierung und Vereinfachung der klinischen Tumorzytodiagnostik mittels Zytozentrifugation