[The mutagenic effect of new chemical substances. III. The mutagenic effect of several hydroxylamine derivatives].
The mutagenic effect of 21 new hydroxylamine derivatives was studied on biochemical mutants of Escherichia coli P-678 and Actinomyces rimosus 222. The Iver--Szybalsky method was used for the preliminary selection of mutagens. Dose-effect curves were plotted for the most efficient mutagens. Among the compounds studied 4 hydroxylamine derivatives were observed to have a mutagenic effect. The most efficient among them proved to be 0-(4-metoxybenzyl)-hydroxylamine and 0-(gamma-chlorocrotyl) hydroxylamine that induced reversions in the threonine locus of E. coli P-678 and in the lysine locus of Act. rimosus 222, being more efficient than hydroxylamine, the generally known mutagen. The dependence of the mutagenic activity of the compounds studied on their chemical structure is investigated.
D004926:Escherichia coli / Q000187:drug effects*; D006898:Hydroxylamines / Q000494:pharmacology*; D009153:Mutagens; D013302:Streptomyces / Q000187:drug effects*; D013329:Structure-Activity Relationship
D006898:Hydroxylamines; D009153:Mutagens
Mutagennoe deĭstvie novykh khimicheskikh soedineniĭ. Soobshchenie III. Izuchenie mutagennogo deĭstviia nekotorykh proizvodnykh gidroksilamina