Passive immunotherapy in HBs Ag fulminant hepatitis. Results on antigenaemia and survival.
19 patients with HBs Ag-positive fulminant hepatitis underwent exchange transfusions and anti-HBs-rich plasma infusions. Circulating HBs Ag disappeared in 17 cases. Circulating anti-HBs detected by RIA was higher in cases with liver regeneration. There was no correlation between circulating anti-HBs level and the amount of anti-HBs-rich plasma administered. Recovery was observed in 36% of the cases and liver regeneration in 47%. As the beneficial effect of such a treatment is not yet evident, a controlled trial should require pairing of patients with respect to the number of exchange transfusions and amount of real or placebo anti-HBs.
D000293:Adolescent; D000328:Adult; D000906:Antibodies / Q000008:administration & dosage; D002986:Clinical Trials as Topic; D005078:Exchange Transfusion, Whole Blood; D005260:Female; D006510:Hepatitis B Antibodies / Q000008:administration & dosage / Q000032:analysis; D006511:Hepatitis B Antigens / Q000032:analysis; D006801:Humans; D007167:Immunotherapy; D008111:Liver Function Tests; D008115:Liver Regeneration; D008297:Male; D008875:Middle Aged
D000906:Antibodies; D006510:Hepatitis B Antibodies; D006511:Hepatitis B Antigens