Metabolism of ethosuximide.
Twenty subjects, in a double-blind, controlled, rising dose study, were given ethosuximide either once daily or 3 times daily. Steady-state plasma levels and urinary throughput were proportional to dose and were equivalent whether the daily dose was given as a single or divided dose. This finding adds validity to consideration of the single daily dose regimen as a therapeutic possiblity. The metabolic principles should be considered both in patient management and in the treatment of overdosage.
D000328:Adult; D002849:Chromatography, Gas; D002986:Clinical Trials as Topic; D005013:Ethosuximide / Q000378:metabolism* / Q000494:pharmacology; D006410:Hematopoiesis / Q000187:drug effects; D006801:Humans; D007677:Kidney Function Tests; D008297:Male; D013237:Stereoisomerism; D013997:Time Factors
D005013:Ethosuximide