Clinical trial of piracetam in disorders of consciousness due to head injury.
The authors first remind some toxicological and some pharmacological properties of piracetam (Nootropil), then present the results of a test giving evidence of the presence of this drug in the cerebrospinal fluid after intravenous administration to man. In a double blind study, the activity of piracetam is tested on 31 patients suffering from coma after head injury. Only 27 patients without intracranial space occupying lesions are taken into account. Methods and results are described. Piracetam, although showing no activity on mortality, improves the level of consciousness.
D000328:Adult; D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects; D002986:Clinical Trials as Topic; D003128:Coma / Q000188:drug therapy* / Q000209:etiology; D003243:Consciousness; D006259:Craniocerebral Trauma / Q000150:complications*; D006801:Humans; D010539:Permeability; D010889:Piracetam / Q000494:pharmacology / Q000627:therapeutic use*; D010919:Placebos; D011760:Pyrrolidinones / Q000627:therapeutic use*
D010919:Placebos; D011760:Pyrrolidinones; D010889:Piracetam