Studies on specific humoral immunity in leukemia.
The paper concerns some results in studies on humoral immunity in human and animal leukemia obtained in author's laboratory (1970-1974). The data presented here disclose immunological mechanisms of mice viral leukemogenesis (cytotoxic and blocking antibodies interrelations). The existence of specific humoral immune response in acute leukemia patients was established (immunoglobulins with the properties of antibodies were revealed in 42.6% of patients). Different forms of specific humoral immunity manifestations in different types of leukemia were distinguished (areactive, nonspecific, cytotoxic, blocking and mixed forms.
D000818:Animals; D000912:Antibodies, Neoplasm; D000917:Antibody Formation; D000936:Antigen-Antibody Complex; D000951:Antigens, Neoplasm; D003601:Cytotoxicity Tests, Immunologic; D005455:Fluorescent Antibody Technique; D005620:Freund's Adjuvant; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D007942:Leukemia, Experimental / Q000209:etiology / Q000276:immunology*; D007945:Leukemia, Lymphoid / Q000276:immunology*; D015470:Leukemia, Myeloid, Acute / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains
D000912:Antibodies, Neoplasm; D000936:Antigen-Antibody Complex; D000951:Antigens, Neoplasm; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D005620:Freund's Adjuvant