[Controlled clinical trial of parsalmide in patients with subacute and chronic arthro-neuro-mypathies].
Controlled experiments were carried out to compare the anti-inflammatory, analgesic, muscle-relaxing and anxiolytic-tranquillizing activities of a new compound, parsalmide, and indomethacin. The study was conducted on 40 patients of both sexes suffering from syndromes involving neuromotor deficiency of various origin and the double blind between patient, technique was used. Overall evaluation of the activities of the two drugs did not reveal statistically significant differences although parsalmide was more effective with "pain", "tumefaction" and "anxiety" symptoms. This latter finding is particularly interesting owing to the frequent association of neuroanxiety disturbances in such patients. General and local tolerance was good with both drugs.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use*; D001549:Benzamides / Q000009:adverse effects / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use; D007592:Joint Diseases / Q000188:drug therapy*; D007596:Joints / Q000293:injuries; D008297:Male; D008875:Middle Aged; D009443:Neuritis / Q000188:drug therapy*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001549:Benzamides; D007213:Indomethacin
Sperimentazione clinica controllata di parsalmide in pazienti affetti da artro-neuro-miopatie subacute e croniche