Histological aspects of arterial abnormalities produced by X-irradiation of the aortic and branchial arches in the chick embryo.
Low dose X irradiations centred on one or two aortic and branchial arches of 3-day check embryos result in teratogenic effects on the arteries (21-92%) and in low mortality (4-12%). Histological studies of abnormal arteries show different structural malformations of the arterial wall: inorganized arterial fibres, abnormal intima, newly formed arterial tissue in arterial lumen, coalescence of two arteries. It is suggested that a disturbance at the aortic differentiation level results under our experimental conditions in the observed arterial abnormalities.
D000818:Animals; D001011:Aorta / Q000002:abnormalities* / Q000473:pathology; D001934:Branchial Region / Q000473:pathology; D002642:Chick Embryo / Q000528:radiation effects*; D011831:Radiation Genetics; D014965:X-Rays / Q000009:adverse effects