Reduced lethality in mice receiving a combined dose of cyclophosphamide and busulphan.
Animals treated with a sufficiently high dose of busulphan die about 14 days later from bone marrow failure. A single, appropriately timed injection of cyclophosphamide can save these mice. The nature of this protection is shown to be the cyclophosphamide induced elaboration of a humoral factor which stimulates haemopoietic recovery.
D000818:Animals; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D002066:Busulfan / Q000633:toxicity*; D002999:Clone Cells; D003115:Colony-Stimulating Factors / Q000032:analysis; D003520:Cyclophosphamide / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D005269:Femur / Q000032:analysis; D006098:Granulocytes / Q000187:drug effects; D006410:Hematopoiesis / Q000187:drug effects; D007958:Leukocyte Count; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D013156:Splenectomy; D014184:Transplantation, Homologous
D003115:Colony-Stimulating Factors; D003520:Cyclophosphamide; D002066:Busulfan