Mucosal melanoma. Immunological findings in a rare case treated with BCG vaccine, autologous tumor cells, and cytarabine.
A case of mucosal melanoma involved the bronchus, maxillary sinus, and small intestine. Treatment with a combination of autologous tumor cells, BCG vaccine, and cytarabine was given, and the immunological system was investigated regularly. After each treatment episode, there was a transient improvement of the cell-mediated immunity to melanoma antigens. The cutaneous delayed hypersensitivity reaction to PPD was converted to a permanently positive one. In the final stage of the disease, the number of T cells was decreased. Difficulty occurred in interpreting the immunological findings according to the clinical condition.
D000951:Antigens, Neoplasm; D001500:BCG Vaccine / Q000627:therapeutic use; D001984:Bronchial Neoplasms / Q000188:drug therapy / Q000276:immunology* / Q000628:therapy; D003561:Cytarabine / Q000627:therapeutic use; D006801:Humans; D007111:Immunity, Cellular; D007413:Intestinal Mucosa / Q000276:immunology; D007414:Intestinal Neoplasms / Q000188:drug therapy / Q000276:immunology* / Q000628:therapy; D007421:Intestine, Small / Q000276:immunology; D008297:Male; D008443:Maxillary Sinus / Q000276:immunology; D008545:Melanoma / Q000188:drug therapy / Q000276:immunology* / Q000628:therapy; D008875:Middle Aged; D009092:Mucous Membrane / Q000276:immunology; D010255:Paranasal Sinus Neoplasms / Q000188:drug therapy / Q000276:immunology* / Q000628:therapy; D014374:Tuberculin Test
D000951:Antigens, Neoplasm; D001500:BCG Vaccine; D003561:Cytarabine