Assessment of a test of renal viability.
A test of renal viability using the uptake of 125I-iodohippurate by kidney biopsy specimens has been developed. It is applicable to all kidneys irrespective of the method of storage. The uptake of 125I-iodohippurate in experimental kidneys correlated well with warm or cold ischaemia time and subsequent renal function. The test was used for human cadaver kidneys offered for transplantation and there was good correlation between iodohippurate uptake and warm ischaemic time. With this test, prediction of renal function was accurate in 85% of human cadaver kidneys transplanted. Pulsatile perfusion had no effect on cadaver kidneys as measured by this test.
D000818:Animals; D001706:Biopsy; D003080:Cold Temperature; D005260:Female; D007465:Iodohippuric Acid / Q000378:metabolism; D007511:Ischemia; D007668:Kidney / Q000098:blood supply / Q000378:metabolism; D016030:Kidney Transplantation; D051381:Rats; D013997:Time Factors; D014022:Tissue Survival; D014184:Transplantation, Homologous; D014508:Urea / Q000097:blood
D007465:Iodohippuric Acid; D014508:Urea