A fraction isolated from porcine upper small intestine stimulating pepsin secretion in the cat.
The preliminary purification of a material, apparently distinct from any hitherto isolated gastrointestinal hormone, with pepsin release stimulating activity in the cat is described. This material has shown no inhibitory effect on pentagastrin-stimulated secretion of acid, no effect of its own on gastric acid secretion and antral motility, and only a weak stimulatory effect on pancreatic secretion of bicarbonate.
D000818:Animals; D002415:Cats; D005750:Gastric Juice / Q000378:metabolism*; D005769:Gastrointestinal Motility / Q000187:drug effects; D007421:Intestine, Small / Q000032:analysis* / Q000502:physiology; D010418:Pentagastrin / Q000494:pharmacology; D010434:Pepsin A / Q000378:metabolism*; D012636:Secretory Rate / Q000187:drug effects; D013270:Stomach / Q000502:physiology; D014020:Tissue Extracts / Q000302:isolation & purification / Q000494:pharmacology*
D014020:Tissue Extracts; D010434:Pepsin A; D010418:Pentagastrin