Immune potential in human uraemia. 1. Relationship of glomerular filtration rate to depression of immune potential.
Aspects of immune potential in uraemic subjects, categorized by glomerular filtration rate, were intercompared and compared with results obtained from a group of normal volunteers. Evidence is presented to show that depression of both cellular and humoral immune potential occurs with progressive reduction of glomerular filtration rate. Lymphocyte transformation testing to the non-specific mitogen PHA revealed a significant elevation of blastogenic response in uraemia after 96 hours of incubation.
D000328:Adult; D000907:Antibodies, Bacterial / Q000032:analysis; D000917:Antibody Formation; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007109:Immunity; D007136:Immunoglobulins / Q000032:analysis; D007158:Immunologic Techniques; D008213:Lymphocyte Activation; D008297:Male; D008722:Methods; D008875:Middle Aged; D012475:Salmonella / Q000276:immunology; D012882:Skin Tests; D013743:Tetanus Antitoxin / Q000032:analysis; D014511:Uremia / Q000276:immunology*
D000907:Antibodies, Bacterial; D007136:Immunoglobulins; D013743:Tetanus Antitoxin