title: Effect of topically applied acidulated phosphate fluoride on dental caries.
abstract: A 4-year clinical trial was conducted to determine the effect on dental caries incidence of the use of acidulated phosphate fluoride (APF 1.23%). 1,653 Egyptian schoolchildren aged 8 years started the trial. Dental caries was assessed annually by clinical examinations. 1,027 children completed the study. After 4 years, the children in the study group showed a mean of 2.58 DMF teeth and 2.68 DMF surfaces. Those in the control group showed 2.58 and 2.67, respectively. No significant reduction in the caries increment was observed at 0.05 level. The findings of this study suggest that topical application of fluoride does not decrease pit and fissure caries.
mesh_terms: D000149:Acidulated Phosphate Fluoride / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D002986:Clinical Trials as Topic; D004245:DMF Index; D003731:Dental Caries / Q000517:prevention & control*; D004341:Drug Evaluation; D004534:Egypt; D005459:Fluorides / Q000627:therapeutic use*; D005460:Fluorides, Topical; D006801:Humans
chemical_list: D005460:Fluorides, Topical; D000149:Acidulated Phosphate Fluoride; D005459:Fluorides