The effects of tryptophol on immune responses and it implications toward trypanosome-induced immunosuppression.
Daily administration of tryptophol to laboratory rodents resulted in significantly depressed antibody production of heterologous red blood cell challenge, did not alter cellular-mediated responses to oxazalone. These results suggest that trypanosome-produced tryptophol may account for the immunodepression observed during trypanosomiasis.
D000017:ABO Blood-Group System; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D003411:Arvicolinae; D002286:Carcinoma, Ehrlich Tumor; D004912:Erythrocytes / Q000276:immunology; D006801:Humans; D007165:Immunosuppression Therapy; D007211:Indoles / Q000494:pharmacology*; D051379:Mice; D010081:Oxazolone / Q000276:immunology; D013154:Spleen / Q000187:drug effects / Q000378:metabolism; D013936:Thymidine / Q000378:metabolism; D014345:Trypanosoma; D000438:Alcohols
D000017:ABO Blood-Group System; D007211:Indoles; D010081:Oxazolone; D013936:Thymidine; C005949:tryptophol; D000438:Alcohols