title: Conversion of pepsinogen into pepsin is not a one-step process.
abstract: By incubation of pepsinogen with pepstatin at pH2.5, the first 'active' protein generated on activation is trapped in an inactive complex. The first activation peptide liberated has been identified as residues 1-16 from the pepsinogen sequence. This suggests a sequential mechanism rather than a one-step formation of pepsin.
mesh_terms: D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D010434:Pepsin A / Q000096:biosynthesis*; D010455:Peptides / Q000032:analysis; D012995:Solubility; D013552:Swine
chemical_list: D000596:Amino Acids; D010455:Peptides; D010434:Pepsin A