Coagulation and renal disease.
The role of coagulation in relation to the aetiology, pathogenesis and progression of renal diseases is discussed. The intimate interdependence between the coagulation process and platelet function, fibrinolysis, complement activation and kinin release is emphasized; these processes are usually involved in most types of immunological inflammation. Coagulation abnormalities occurring in distinct renal diseases are reviewed and the benefits derived from therapy aimed at correcting these abnormalities are compared with the known natural histories of these diseases.
D000818:Animals; D000925:Anticoagulants / Q000627:therapeutic use; D000936:Antigen-Antibody Complex; D001778:Blood Coagulation Disorders / Q000150:complications* / Q000175:diagnosis; D004195:Disease Models, Animal; D004211:Disseminated Intravascular Coagulation / Q000150:complications; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D005921:Glomerulonephritis / Q000209:etiology; D006084:Graft Rejection / Q000209:etiology; D006801:Humans; D007674:Kidney Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D016030:Kidney Transplantation; D009404:Nephrotic Syndrome / Q000150:complications; D011225:Pre-Eclampsia / Q000150:complications; D011247:Pregnancy; D012771:Shock, Hemorrhagic / Q000150:complications; D012790:Shwartzman Phenomenon / Q000150:complications; D014184:Transplantation, Homologous
D000925:Anticoagulants; D000936:Antigen-Antibody Complex; D005343:Fibrinolytic Agents