[Evaluation of phenylalkanoic acid derivatives in the management of rheumatic diseases as well as various explanations on the doctrine of clinical research technics].
The pharmacology and toxicology of the phenylalkanoic derivatives are discussed with particular reference to Ibuprofen. Clinical trials of Ibuprofen are reviewed and their methodology assessed. A more rational approach to anti-inflammatory drug evaluation is suggested and the need for closer international co-operation in establishing a standardized approach to clinical trial methodology is emphasised.
D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D001241:Aspirin / Q000627:therapeutic use; D055598:Chemical Phenomena; D002621:Chemistry; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects / Q000627:therapeutic use*; D010648:Phenylacetates / Q000627:therapeutic use; D010666:Phenylpropionates / Q000627:therapeutic use*
D010648:Phenylacetates; D010666:Phenylpropionates; D001241:Aspirin; D007052:Ibuprofen
Eine Bewertung der Phenylalkanoinsüre-Derivate in der Behandlung rheumatischer Erkrankungen sowie einige Erläuterungen zur Lehre der klinischen Versuchsmethoden