title: Translocation of a discrete piece of deoxyribonucleic acid carrying an amp gene between replicons in Eschericha coli.
abstract: A number of well-characterized R plasmids (R1drd 19. K1.R100-1, R46, R55-1, R64-11, R388, and R751) will mobilize an integrated amp gene from the chromosome of Escherichia coli K-12. R391 will not act in this way. The process involves recombination, and in each case the mobilizing plasmid acquires an additional piece of deoxyribonucleic acid of molecular weight 4 X 10(6). Acquisition of this deoxyribonucleic acid may impair the transfer properties of the recombinant plasmid in some cases. The process will occur in a recA background.
mesh_terms: D000667:Ampicillin / Q000494:pharmacology*; D002228:Carbenicillin / Q000494:pharmacology; D002869:Chromosome Aberrations; D004269:DNA, Bacterial / Q000032:analysis; D004270:DNA, Circular / Q000032:analysis; D004926:Escherichia coli / Q000032:analysis / Q000187:drug effects*; D005796:Genes; D008970:Molecular Weight; D009154:Mutation; D010403:Penicillin Resistance; D011815:R Factors; D011995:Recombination, Genetic; D014178:Translocation, Genetic; D014295:Trimethoprim / Q000494:pharmacology
chemical_list: D004269:DNA, Bacterial; D004270:DNA, Circular; D000667:Ampicillin; D014295:Trimethoprim; D002228:Carbenicillin