Survey of the current status of the clinical uses of antilymphocyte serum.
A limited degree of effectiveness of antilymphoid globulin in clinical kidney and bone marrow transplantation has been described. It may also be useful for the prolongation of temporary skin allografts for burn patients and may be valuable as an adjunct in the treatment of certain autoimmune diseases. The use of antilymphoid globulin with donor antigen to facilitate allograft enhancement has been reviewed. An instance of possible enhancement of a mismatched cadaveric renal allograft in a highly sensitized recipient given antilymphoid globulin and donor marrow is recorded. Use of antilymphoid globulin to facilitate enhancement with donor antigen is probably the next major application of antilymphoid globulin.
D000818:Animals; D000961:Antilymphocyte Serum / Q000627:therapeutic use*; D001327:Autoimmune Diseases / Q000628:therapy*; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D002056:Burns / Q000601:surgery; D006041:Goats / Q000276:immunology; D006084:Graft Rejection; D006736:Horses / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D007165:Immunosuppression Therapy / Q000379:methods*; D016030:Kidney Transplantation; D051379:Mice; D011379:Prognosis; D011817:Rabbits / Q000276:immunology; D016038:Skin Transplantation; D014181:Transplantation Immunology; D014184:Transplantation, Homologous / Q000379:methods*
D000961:Antilymphocyte Serum