Herpes gestationis: fine structural pattern of immunoglobulin deposits in the skin in vivo.
IgG and C3 deposits were observed in the basement membrane zone in a case with herpes gestationis. In addition, circulating IgG anti-basement membrane antibodies were found. Electron microscopic immunocytochemical investigations, performed with a peroxidase-antiperoxidase sandwich technique, revealed the in vivo-bound IgG to be localized at the epidermal basal lamina and to exhibit a distribution pattern which is identical to that reported for bullous pemphigoid.
D000328:Adult; D001485:Basement Membrane / Q000276:immunology / Q000648:ultrastructure; D003176:Complement C3 / Q000378:metabolism; D005260:Female; D005455:Fluorescent Antibody Technique; D006735:Horseradish Peroxidase / Q000037:antagonists & inhibitors; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism; D008297:Male; D006559:Pemphigoid Gestationis / Q000276:immunology* / Q000473:pathology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology*; D012867:Skin / Q000276:immunology* / Q000648:ultrastructure; D012872:Skin Diseases, Vesiculobullous / Q000276:immunology*
D003176:Complement C3; D007074:Immunoglobulin G; D006735:Horseradish Peroxidase