Failure of increased brain gamma-aminobutyric acid levels to influence amphetamine-induced stereotyped behavior.
Increased brain gamma-aminobutyric acid (GABA) levels secondary to the administration of sodium valproate failed to inhibit amphetamine-induced stereotyped behavior. This observation raises some doubt as to whether GABA plays a role in the physiology of the striatum and suggests that GABA does not play a role in the pathophysiology of chorea. If this is true, pharmacologic attempts to increase brain GABA may not improve human choreatic disorders.
D000613:Aminobutyrates / Q000378:metabolism*; D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D001519:Behavior / Q000187:drug effects*; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry / Q000187:drug effects; D004347:Drug Interactions; D006168:Guinea Pigs; D006801:Humans; D008297:Male; D013239:Stereotyped Behavior / Q000187:drug effects*; D014635:Valproic Acid / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000032:analysis / Q000378:metabolism*
D000613:Aminobutyrates; D005680:gamma-Aminobutyric Acid; D014635:Valproic Acid; D000661:Amphetamine