title: Pattern of somatic segregation of the cytoplasmic drug-resistance factors in yeast.
abstract: The pattern of somatic segregation of the cytoplasmic factors confering resistances to chloramphenicol, erythromycin and oligomyin in S. cerevisiae was studied. The fractions of the zygotes heterozygous for the chloramphenicol-resistance factor and for the erythromycin-resistance factor decreased exponentially with generation number of zygotes. The rate of the segregation was highest for the chloramphenicol-resistance factor and lowest for the oligomycin-resistance factor. The segregation rate as well as the transmission polarity of the chloramphenicol-resistance factor varied with different carbon sources with which the parental haploids were grown prior to mating.
mesh_terms: D002701:Chloramphenicol; D003593:Cytoplasm; D004352:Drug Resistance, Microbial; D004917:Erythromycin; D005111:Extrachromosomal Inheritance; D005838:Genotype; D006579:Heterozygote; D009840:Oligomycins; D011815:R Factors; D011995:Recombination, Genetic; D012441:Saccharomyces cerevisiae
chemical_list: D009840:Oligomycins; D004917:Erythromycin; D002701:Chloramphenicol