Successful treatment of dendritic keratitis with human leukocyte interferon. A controlled clinical study.
There were 40 virologically confirmed cases of dendritic keratitis treated in a randomized double-blind placebo-controlled study. After thermomechanical debridement of the corneal epithelium, the patients received two drops of human leukocyte interferon (HLI) twice daily. The activity was 3 X 10(-6) units/ml. HLI significantly accelerated healing and inhibited virus shedding. It remains to be studied whether HLI will be equally effective in the prophylaxis of late herpes recurrences.
D002986:Clinical Trials as Topic; D003646:Debridement; D006801:Humans; D007372:Interferons / Q000627:therapeutic use*; D007635:Keratitis, Dendritic / Q000188:drug therapy*
D007372:Interferons