Allogeneic marrow grafting for treatment of aplastic anemia: a follow-up on long-term survivors.
Eleven of twenty-four patients with severe aplastic anemia given marrow grafts from HLA-identical siblings between October 1970 and March 1973 are alive with normal marrow function and continued evidence of engraftment 3-5 yr later. Ten have been leading normal lives with no immunosuppressive or other drug therapy since day 100 postgrafting. One has had chronic graft-versus-host disease of the skin which is now slowly improving with no therapy. He returned to full-time employment in the summer of 1975. The long-term well-being of almost half of our initial patients emphasizes the importance of marrow transplantation for the treatment of severe aplastic anemia.
D000741:Anemia, Aplastic / Q000097:blood / Q000276:immunology / Q000628:therapy*; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D005500:Follow-Up Studies; D006801:Humans; D010641:Phenotype; D013997:Time Factors; D014184:Transplantation, Homologous