title: A novel bacteriophage defence mechanism: the anti-restriction protein.
abstract: Bacteriophage T3 and T7 protect their DNA from restriction by producing, as the earliest detectable phage functions, anti-restriction proteins. Although the two phage proteins differ in their chromatographic and antigenic properties, they act by the same mechanism: the anti-restriction proteins inhibit E. coli K12 restriction endonuclease by direct interaction.
mesh_terms: D003090:Coliphages / Q000201:enzymology* / Q000235:genetics; D004262:DNA Restriction Enzymes / Q000037:antagonists & inhibitors*; D004279:DNA, Viral / Q000378:metabolism; D005796:Genes; D006867:Hydrolases / Q000378:metabolism; D012436:S-Adenosylmethionine / Q000378:metabolism; D014764:Viral Proteins / Q000235:genetics / Q000494:pharmacology* / Q000502:physiology; D014779:Virus Replication
chemical_list: D004279:DNA, Viral; D014764:Viral Proteins; D012436:S-Adenosylmethionine; D006867:Hydrolases; D004262:DNA Restriction Enzymes