Antimalarials V: aminobenzothiazoles.
Four mono- and dialkylated 4-aminobenzothiazoles (VII-X) were prepared as analogs of potent causal prophylactic drugs in the 8-aminoquinoline series. Compounds VII and VIII were toxic at 80 mg/kg in the chick; IX was inactive at 640 mg/kg. In a sporozoite-induced mouse test system, X was inactive at 30 mg/kg and toxic at 480 mg/kg. None of the compounds was active as a suppressive drug.
D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis / Q000627:therapeutic use; D002645:Chickens; D008288:Malaria / Q000188:drug therapy; D008722:Methods; D051379:Mice; D010962:Plasmodium berghei; D013844:Thiazoles / Q000138:chemical synthesis / Q000627:therapeutic use
D000962:Antimalarials; D013844:Thiazoles