In vitro sensitivity of hospital strains of Serratia marcescens to chemotherapeutic agents.
The susceptibility of 83 non-pigmented Serratia marcescens strains was determined by an agar dilution technique. They originated from miscellaneous pathological specimens submitted to the diagnostic laboratory during a nosocomial infection outbreak in 1974. All strains were completely resistant to 128 mug/ml of cephalothin, colistin sulphomethate, lincomycin and penicillin G. They were also resistant to clinically attainable concentrations of ampicillin, chloramphenicol, erythromycin, novobiocin and tetracycline. With regard to drugs with some activity 84% of the strains were susceptible to nalidixic acid, 48% to sulphamethoxazole, 57% to streptomycin, 60% to kanamycin, 61% to gentamicin, 85% to co-trimoxazole and 100% to amikacin. Environmental strains isolated from the infected units were strikingly more sensitive than the patient strains.
D000583:Amikacin / Q000494:pharmacology; D000667:Ampicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002228:Carbenicillin / Q000494:pharmacology; D002701:Chloramphenicol / Q000494:pharmacology; D003428:Cross Infection / Q000382:microbiology*; D004917:Erythromycin / Q000494:pharmacology; D005839:Gentamicins / Q000494:pharmacology; D006801:Humans; D007612:Kanamycin / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009268:Nalidixic Acid / Q000494:pharmacology; D009675:Novobiocin / Q000494:pharmacology; D012293:Rifampin / Q000494:pharmacology; D012706:Serratia marcescens / Q000187:drug effects*; D013183:Sputum / Q000382:microbiology; D013307:Streptomycin / Q000494:pharmacology; D013420:Sulfamethoxazole / Q000494:pharmacology; D013752:Tetracycline / Q000494:pharmacology; D014295:Trimethoprim / Q000494:pharmacology; D014556:Urine / Q000382:microbiology; D014946:Wound Infection / Q000382:microbiology
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D009675:Novobiocin; D009268:Nalidixic Acid; D007612:Kanamycin; D004917:Erythromycin; D002701:Chloramphenicol; D000667:Ampicillin; D000583:Amikacin; D014295:Trimethoprim; D013752:Tetracycline; D002228:Carbenicillin; D013420:Sulfamethoxazole; D012293:Rifampin; D013307:Streptomycin