Mutagenic actions of chlorocholine chloride.
Chlorocholine chloride, at concentrations of 0.2 to 0.5 M (3.2 to 7.9%) between pH 5 and 8, showed no significant mutagenic effect whereas at the same concentrations at pH 9 it caused mutations, in a valine-sensitive strain of E. coli K12. Treatment of E. coli B with chlorocholine chloride at 0.5 M and pH 9 resulted in auxotrophic and regulatory deficient (valine-sensitive) mutants. The mutagenic effects of chlorocholine chloride were compared with the effects caused by the food additive NaHSO3.
D002716:Chlormequat / Q000494:pharmacology*; D004926:Escherichia coli / Q000378:metabolism*; D009153:Mutagens; D009154:Mutation; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*; D014633:Valine / Q000378:metabolism
D009153:Mutagens; D000644:Quaternary Ammonium Compounds; D002716:Chlormequat; D014633:Valine