Steroid excretion in anorexia nervosa patients.
Seven anorexia nervosa (A.N.) patients had reduced urinary excretion values of tetrahydrocortisone (THE), androsterone (A) and 5alpha-tetrahydrocortisol (5alpha-THF). THE to tetrahydrocortisol (THF), A to aetiocholanolone (Ae) and 5alpha-THF to THF ratios were all significantly reduced. Six A.N. patients had oral metyrapone tests with quantitatively normal but delayed urinary 3alpha,17alpha,21-trihydroxy-5beta-pregnan-20-one (THS) response. The steroid determinations were done by capillary gaschromatography, which proves to be of value in the study of the above mentioned metabolic abnormalities.
D000293:Adolescent; D000328:Adult; D000738:Androsterone / Q000652:urine*; D000856:Anorexia Nervosa / Q000652:urine*; D002849:Chromatography, Gas; D003348:Cortisone / Q000031:analogs & derivatives*; D005043:Etiocholanolone / Q000652:urine*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000031:analogs & derivatives*; D008797:Metyrapone; D011278:Pregnanes / Q000652:urine; D013760:Tetrahydrocortisol / Q000652:urine*; D013761:Tetrahydrocortisone / Q000652:urine*
D011278:Pregnanes; D013761:Tetrahydrocortisone; D013760:Tetrahydrocortisol; D005043:Etiocholanolone; D000738:Androsterone; D003348:Cortisone; D006854:Hydrocortisone; D008797:Metyrapone