Genetic regulation of macrophage functions.
Normal phagocytic function is genetically determined but maintained in a rather narrow range of variation. Phagocytosis stimulation induced by different agents is variable according to species, strains or individuals. Variation is environmental, to a great extent, but has also a genetic component which differs in each case. Selective breeding for macrophage responsiveness to triolein stimulation was successful. However, the relevant genes have only a small effect on antibody synthesis. Macrophages of mice selected for high and low antibody synthesis have a similar phagocytic function but their capacities of antigen processing are quite different.
D000818:Animals; D000917:Antibody Formation; D001500:BCG Vaccine; D002175:Candida; D002244:Carbon; D002857:Chromium / Q000378:metabolism; D003433:Crosses, Genetic; D004912:Erythrocytes; D005260:Female; D005796:Genes; D007700:Kinetics; D008264:Macrophages / Q000276:immunology / Q000378:metabolism*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009163:Mycobacterium bovis; D010587:Phagocytosis; D012737:Sex Factors; D012756:Sheep; D013045:Species Specificity; D013154:Spleen / Q000276:immunology; D013156:Splenectomy; D014304:Triolein / Q000378:metabolism
D001500:BCG Vaccine; D002857:Chromium; D014304:Triolein; D002244:Carbon