The effect of imidazole on the disruption of the blood-aqueous barrier in the rabbit eye.
The aqueous flare (AF) of an intact rabbit eye was measured by a photoelectrical instrument and the intraocular pressure by vibration tonometry. Prior treatment with imidazole given intraperitoneally noticeably inhibited the disruption of the blood-aqueous barrier in rabbit eyes induced by topical prostaglandin E2 (PGE)2, topical arachidonic acid (AA), infrared irradiation of the iris, endotoxin of Proteus mirabilis given intravenously, and alpha-melanocyte-stimulating hormone (alpha-MSH) given subcutaneously. Prior treatment with imidazole given topically had no effect on the disruption of the blood aqueous barrier caused by topical PGE2, topical AA, infrared irradiation of the iris, or endotoxin of P. mirabilis given intravenously, but facilitated and potentiated strongly the response to alpha-MSH given subcutaneously. Prior treatment with topical imidazole did not affect the histological changes of the anterior ciliary processes induced by alpha-MSH given subcutaneously.
D000287:Administration, Topical; D000818:Animals; D001082:Aqueous Humor / Q000187:drug effects* / Q000528:radiation effects; D001095:Arachidonic Acids / Q000494:pharmacology; D004731:Endotoxins / Q000494:pharmacology; D005260:Female; D007093:Imidazoles / Q000008:administration & dosage / Q000494:pharmacology*; D007259:Infrared Rays; D007274:Injections, Intraperitoneal; D007429:Intraocular Pressure / Q000187:drug effects; D009074:Melanocyte-Stimulating Hormones / Q000494:pharmacology; D011458:Prostaglandins E / Q000494:pharmacology; D011513:Proteus mirabilis; D011817:Rabbits; D011830:Radiation Effects
D001095:Arachidonic Acids; D004731:Endotoxins; D007093:Imidazoles; D011458:Prostaglandins E; D009074:Melanocyte-Stimulating Hormones