Abnormal cilia in human bronchial epithelium.
Abnormal cilia are a common occurrence in human bronchial epithelium. Bronchial specimens were obtained at surgery or at "immediate autopsy" from patients with neoplastic and nonneoplastic diseases; these patients included smokers and one known nonsmoker. Areas of bronchial epithelium far removed from the tumor mass were studied. Ciliary abnormalities fell into four major categories: (1) cilia with a single axoneme and excess cytoplasmic matrix; (2) compound cilia; (3) intracytoplasmic microtubular doublets; and (4) cilia within periciliary sheaths.
D000230:Adenocarcinoma / Q000473:pathology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D001980:Bronchi / Q000473:pathology*; D002277:Carcinoma / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D002923:Cilia / Q000473:pathology* / Q000648:ultrastructure; D002986:Clinical Trials as Topic; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000473:pathology*; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D008679:Metaplasia; D008854:Microscopy, Electron; D008875:Middle Aged; D012907:Smoking