title: Persistent fetal circulation. Two cases with myocardial dysfunction and severe acidosis.
abstract: Two neonates with the most severe form of persistent fetal circulation are described. Their presentation mimicked severe congenital heart disease. As well as persistent pulmonary hypertension and right-to-left shunting through the ductus arteriosus, they had poor myocardial contractility and atrioventricular valve regurgitation. Associated acidaemia was extreme. They survived with medical management, and the functional abnormalities resolved.
mesh_terms: D000138:Acidosis / Q000209:etiology* / Q000628:therapy; D004374:Ductus Arteriosus, Patent / Q000150:complications* / Q000503:physiopathology; D006801:Humans; D006976:Hypertension, Pulmonary / Q000151:congenital* / Q000209:etiology; D007231:Infant, Newborn; D008297:Male; D008944:Mitral Valve Insufficiency / Q000150:complications / Q000503:physiopathology; D009200:Myocardial Contraction