title: Herpes type-2 virus antigens in human cervical carcinoma.
abstract: Exfoliated cells from the cervices of 22 patients with histologically diagnosed squamous cell carcinoma of the cervix and from those of 24 control women were examined for herpes subtype 2 (HT-2) antigens by indirect immunofluorescence studies. This method demonstrated that cells from all the patients with carcinoma contained antigens related to HT-2 virus. In contrast, squamous cells from the cervices of 24 control women with no cervical disease and of 2 women with chronic cervicitis did not contain such HT-2 antigens. Although an etiologic role of HT-2 virus infection cannot yet be established, it is probable that such infection precedes neoplastic changes.
mesh_terms: D000328:Adult; D000956:Antigens, Viral / Q000032:analysis*; D002584:Cervix Uteri / Q000276:immunology / Q000473:pathology; D005260:Female; D005455:Fluorescent Antibody Technique; D006564:Herpesviridae / Q000276:immunology*; D006801:Humans; D008875:Middle Aged; D002583:Uterine Cervical Neoplasms / Q000276:immunology* / Q000382:microbiology
chemical_list: D000956:Antigens, Viral