Long-term survival of skin allografts in mice treated with fractionated total lymphoid irradiation.
Treatment of recipient Balb/c mice with fractionated, high-dose total lymphoid irradiation, a procedure commonly used in the therapy of human malignant lymphomas, resulted in fivefold prolongation of the survival of C57BL/Ka skin allografts despite major histocompatibility differences between the strains (H-2d and H-2b, respectively). Infusion of 10(7) (C57BL/Ka x Balb/c)F1 bone marrow cells after total lymphoid irradiation further prolonged C57BL/Ka skin graft survival to more than 120 days. Total lymphoid irradiation may eventually prove useful in clinical organ transplantation.
D000818:Animals; D005260:Female; D006084:Graft Rejection / Q000528:radiation effects*; D007958:Leukocyte Count; D008214:Lymphocytes / Q000276:immunology; D008221:Lymphoid Tissue / Q000528:radiation effects*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D011830:Radiation Effects; D016038:Skin Transplantation; D013997:Time Factors; D014184:Transplantation, Homologous; D014965:X-Rays