title: Prevalence of cholelithiasis in men and women ingesting a serum-cholesterol-lowering diet.
abstract: This study was carried out to ascertain whether, as has been suggested, the ingestion of a serum-cholesterol-lowering diet would be conducive to cholelithiasis. The prevalence of gallstones was studied in autopsied male and female patients of two mental hospitals in connection with a long-term controlled trial on prevention of coronary heart disease by means of a diet with a high polyunsaturated/saturated fatty acid ratio. The prevalence of gallstones was in men: 20/89 (equals 22.5%) on cholesterol-lowering diet and 11/44 (equals 25%) on normal diet; and in women: 151/262 (equals 42%) on cholesterol-lowering diet and 29/62 (equals 47%) on normal diet. It was concluded that in our trial the cholesterol-lowering diet was not lithogenic.
mesh_terms: D000368:Aged; D002769:Cholelithiasis / Q000453:epidemiology* / Q000209:etiology; D002784:Cholesterol / Q000097:blood*; D002986:Clinical Trials as Topic; D003327:Coronary Disease / Q000517:prevention & control; D004041:Dietary Fats / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D004041:Dietary Fats; D002784:Cholesterol