Prevention of lethal pseudomonas bacteremia with epimerase-deficient E. coli antiserum.
All of these experiments demonstrate that despite many microbiologic differences between Pseudomonas and the enteric rods, there is a close immunologic relationship between their endotoxin cores. These studies also show that by genetic manipulation we can unmask a protective antigen for preparing antiserum with a broad range of activity, even in the face of neutropenia. Production of potent human J5 antiserum is a safe, simple procedure, making it possible to consider endotoxin core antibody treatment of all Gram negative bacteremia in patients regardless of the causative organism.
D000380:Agranulocytosis / Q000150:complications; D000818:Animals; D004926:Escherichia coli / Q000378:metabolism*; D006801:Humans; D007106:Immune Sera; D007114:Immunization; D007116:Immunization, Passive; D007535:Isomerases / Q000378:metabolism*; D011552:Pseudomonas Infections / Q000150:complications / Q000517:prevention & control*; D011817:Rabbits; D019998:Racemases and Epimerases / Q000378:metabolism*; D018805:Sepsis / Q000150:complications / Q000517:prevention & control*
D007106:Immune Sera; D007535:Isomerases; D019998:Racemases and Epimerases