Influence of thymosterin on immunological reactivity in New Zealand mice.
The influence of thymosterin on immunological reactivity of NZB mice was investigated. Thymosterin was administered three times per week for a period of six weeks to male and female NZB mice. Only lymphocytes from untreated female mice gave the positive results in the macrophage migration inhibition test using native DNA as the stimulating antigen. This effect was suppressed in thymosterin treated females. The administration of thymosterin therefore appears to correct the in vitro delayed hypersensitivity to DNA antigen.
D000818:Animals; D002464:Cell Migration Inhibition; D005260:Female; D007111:Immunity, Cellular / Q000187:drug effects*; D008263:Macrophage Migration-Inhibitory Factors; D008297:Male; D051379:Mice; D008814:Mice, Inbred NZB / Q000276:immunology*; D012737:Sex Factors; D013947:Thymosin / Q000494:pharmacology*; D013949:Thymus Extracts / Q000494:pharmacology*
D008263:Macrophage Migration-Inhibitory Factors; D013949:Thymus Extracts; D013947:Thymosin