[Change of immunologic reactivity of the animal body under the effect of various antiblastic agents during primary immune response].
Tests staged with mice and rats demonstrated 5-fluorouracil, fluorafur, methotrexate, cyclophosphane and vinblastine capable of inhibiting to a different degree the primary immune response and the factors of nonspecific immunity. Methotrexate displays the highest activity and specificity of the immunodepressive effect. By using different doses of the drug in immunizing the animals with sheep erythrocytes and vi-antigens the factors of both specific and non-specific immunity were inhibited in all cases. With their single introduction 5-fluorouracil and fluorofur can stimulate the synthesis of humoral antibodies and have no effect on the immune response. With their multiple administration the immunological reactivity of the organism becomes depressed. The extent of changes involving non-specific factors doses not depend upon the pattern and schedule of the drug administration. Cyclophosphane and vinblastin inhibit the immune response when they are introduced 24 hours after immunization. Vinblastin had the faculty of bringing down the activity of the nonspecific immunity, whereas under the effect of cyclophosphane it did not change, except for the complement.
D000818:Animals; D000921:Antibody-Producing Cells; D000942:Antigens, Bacterial / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002452:Cell Count; D003520:Cyclophosphamide / Q000494:pharmacology; D003864:Depression, Chemical; D004912:Erythrocytes / Q000276:immunology; D005472:Fluorouracil / Q000494:pharmacology; D006388:Hemagglutinins / Q000032:analysis; D006460:Hemolysin Proteins / Q000032:analysis; D007109:Immunity / Q000187:drug effects*; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008727:Methotrexate / Q000494:pharmacology; D051379:Mice; D009113:Muramidase / Q000032:analysis; D011414:Properdin / Q000032:analysis; D051381:Rats; D012485:Salmonella typhi / Q000276:immunology; D012756:Sheep; D005641:Tegafur / Q000494:pharmacology; D014747:Vinblastine / Q000494:pharmacology
D000942:Antigens, Bacterial; D000970:Antineoplastic Agents; D006388:Hemagglutinins; D006460:Hemolysin Proteins; D007166:Immunosuppressive Agents; D011414:Properdin; D005641:Tegafur; D014747:Vinblastine; D003520:Cyclophosphamide; D009113:Muramidase; D005472:Fluorouracil; D008727:Methotrexate
Izmenenie immunologicheskoĭ reaktivnosti organizma zhivotnykh pod vliianiem nekotorykh antiblastomnykh sredstv pri pervichnom immunom otvete