Influence of five different postnatal lifelong treatments on the transplacental carcinogenicity of ethylnitrosourea in Sprague-Dawley rats.
Sprague-Dawley rats received in 10 mg/kg body weight (group I) or 30 mg/kg body weight (group II) ethylnitrosourea (ENU) orally on the 19th day of pregnancy. Their offspring were treated with Bacille Calmette-Guerin, human albumin, hydrocortisone, cyclophosphamide or nicotine starting on the 6th day of life. The ENU treatment significantly reduced the life expectancy of all offspring. Treatment of the offspring did not influence tumor frequency, induction time or localization of neurogenic malignant tumors. Cyclophosphamide treatment of group II offspring increased the number of females bearing mammary carcinomas.
D000418:Albumins / Q000494:pharmacology; D000818:Animals; D001500:BCG Vaccine; D001932:Brain Neoplasms / Q000139:chemically induced*; D003520:Cyclophosphamide / Q000494:pharmacology; D005038:Ethylnitrosourea / Q000633:toxicity*; D005260:Female; D006854:Hydrocortisone / Q000494:pharmacology; D007167:Immunotherapy; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced*; D008431:Maternal-Fetal Exchange; D009163:Mycobacterium bovis / Q000276:immunology; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000628:therapy; D009538:Nicotine / Q000494:pharmacology; D009607:Nitrosourea Compounds / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D013125:Spinal Neoplasms / Q000139:chemically induced*
D000418:Albumins; D001500:BCG Vaccine; D009607:Nitrosourea Compounds; D009538:Nicotine; D003520:Cyclophosphamide; D005038:Ethylnitrosourea; D006854:Hydrocortisone