Pralidoxime mesylate absorption and heart rate response to atropine sulphate following intramuscular administration of solution mixtures.
1. The oxime pralidoxime mesylate (P2S) and atropine sulphate, alone and mixed, have been administered intramuscularly to forty-four human subjects. Doses of 750 mg and 500 mg P2S and 2.0 mg atropine sulphate were used. 2. The presence of P2S had no significant influence, as judged by effect on heart rate, on the absorption of atropine although there was a tendency for atropine to exert its effects more rapidly when administered mixed with P2S. 3. No significant difference in the rate of uptake of P2S as judged by plasma levels following injection, between a combined (plus atropines) and single (P2S alone) intramuscular injection was found.
D000042:Absorption; D001285:Atropine / Q000008:administration & dosage* / Q000378:metabolism / Q000494:pharmacology; D002986:Clinical Trials as Topic; D004338:Drug Combinations; D004347:Drug Interactions; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007273:Injections, Intramuscular; D007408:Intestinal Absorption; D008297:Male; D011220:Pralidoxime Compounds / Q000008:administration & dosage* / Q000378:metabolism / Q000494:pharmacology; D013997:Time Factors
D004338:Drug Combinations; D011220:Pralidoxime Compounds; D001285:Atropine