[Study of the dynamics of lymphocyte receptor affinity for hapten in the process of the primary immune response].
The affinity of the lymphocyte receptors for DNP-determinants was studied by free hapten inhibition of rosette-forming cells. The avidity of the antigen-binding lymphoid cells was found to increase with the advance of time after the immunization. The results suggest that an increase in the cellular avidity during the immune response depended on both the affinity of the gamma-globulin receptors and their concentration on the cell surface.
D000818:Animals; D000917:Antibody Formation; D001666:Binding Sites, Antibody; D004140:Dinitrophenols / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000276:immunology; D006241:Haptens; D006462:Hemolytic Plaque Technique; D007114:Immunization; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice; D008808:Mice, Inbred CBA; D010047:Ovalbumin / Q000276:immunology; D011947:Receptors, Antigen, B-Cell; D013997:Time Factors
D004140:Dinitrophenols; D006241:Haptens; D011947:Receptors, Antigen, B-Cell; D010047:Ovalbumin
Issledovanie dinamiki affinnosti retseptorov leimfotsitov k gaptenu v protsesse pervichnogo immunnogo otveta