title: Effect of mutations in deoxyribonucleic acid repair pathways on the sensitivity of Escherichia coli K-12 strains to nitrofurantoin.
abstract: Escherichia coli K-12 strains that carry mutations in one or more genes coding for proteins involved in repair of deoxyribonucleic acid lesions are more sensitive to the antibiotic nitrofurantoin than are the nonmutant parent strains.
mesh_terms: D001426:Bacterial Proteins / Q000096:biosynthesis; D004260:DNA Repair; D004269:DNA, Bacterial / Q000096:biosynthesis; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects* / Q000378:metabolism; D005796:Genes; D009154:Mutation; D009582:Nitrofurantoin / Q000494:pharmacology*; D011995:Recombination, Genetic; D013307:Streptomycin / Q000494:pharmacology
chemical_list: D001426:Bacterial Proteins; D004269:DNA, Bacterial; D009582:Nitrofurantoin; D013307:Streptomycin