Coagulation studies in long-term survivors after renal allograft transplantation.
Screening coagulation studies were carried out on 69 long-term survivors who had received renal allografts. Fibrinogen levels were significantly raised in this group. Factor VIII activity was increased in 7 of the 11 patients studied. Six long-term survivors of renal allografts demonstrated arterial thrombotic phenomena. The onset of the thrombotic episode occurred at a relatively young age. It is considered that the hypercoagulable state may contribute to the observed increased tendency towards arterial thrombotic phenomena.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000991:Antithrombins / Q000032:analysis; D001779:Blood Coagulation Factors / Q000032:analysis*; D005169:Factor VIII / Q000032:analysis; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D005340:Fibrinogen / Q000032:analysis; D005500:Follow-Up Studies; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000097:blood; D013925:Thromboplastin; D013927:Thrombosis / Q000097:blood; D014184:Transplantation, Homologous
D000991:Antithrombins; D001779:Blood Coagulation Factors; D005230:Fatty Acids, Nonesterified; D005338:Fibrin Fibrinogen Degradation Products; D005169:Factor VIII; D005340:Fibrinogen; D013925:Thromboplastin