E rosette formation by human t lymphocytes: a spontaneous cell mediated cytotoxic phenomenon.
The nature and significance of spontaneous association between unsensitized human T lymphocytes and sheep erythrocytes has been studied in relation to a possible cytotoxic reaction. Human lymphocytes and 51Cr labelled sheep erythrocytes when mixed in ratios of 5 or 10:1 released 70-100% of 51Cr into the supernatants. This suggests that E rosette formation may be the first step in a spontaneous T cell mediated cytotoxic reaction to sheep erythrocytes.
D000818:Animals; D002469:Cell Separation; D004912:Erythrocytes / Q000276:immunology*; D005312:Fetal Blood; D006461:Hemolysis; D006801:Humans; D007111:Immunity, Cellular; D007158:Immunologic Techniques; D012756:Sheep / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*