Radiocirculographic study of the effect of ethyl apovincaminate on the cerebral circulation.
The effect of ethyl apovincaminate (RGH-4405, Cavinton) on cerebral circulation has been studied with radiocirculography (rc) in 12 healthy individuals and 17 patients suffering from cerebrovascular diseases. It was shown that acute Cavinton effect produced prolongation of circulation time both in healthy individuals and in more than half of our patients. Shortening of circulation time was observed in one case. On long-term Cavinton treatment circulation time was prolonged in 7 cases, not changed in 7, while in 3 cases it was shortened. The circulation times measured by rc did not reflect changes in the clinical picture.
D000328:Adult; D000368:Aged; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D002561:Cerebrovascular Disorders / Q000503:physiopathology; D006801:Humans; D008875:Middle Aged; D011865:Radioisotope Dilution Technique; D014748:Vinca Alkaloids / Q000494:pharmacology*
D014748:Vinca Alkaloids