Naturally occurring immunosuppressive agents. II. The ability of cell-free liver extracts to modify the rejection of allogeneic skin grafts in the rabbit.
It has been demonstrated that cell-free extracts of pig, rabbit and human liver, but not of other parenchymal organs, contain a factor or factors capable of suppressing the proliferative responses of allogeneic and xenogeneic lymphoid cells stimulated with PHA, PWM, Con-A and allogeneic lymphocytes. Intravenous injection of the liver extract is capable of modifying significantly the skin allograft rejection reaction in normal adult outbred rabbits. Work is now in progress to isolate this factor and to determine its composition.
D000818:Animals; D002474:Cell-Free System; D006084:Graft Rejection; D007166:Immunosuppressive Agents; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D008110:Liver Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D008213:Lymphocyte Activation; D011817:Rabbits; D016038:Skin Transplantation; D013997:Time Factors; D014184:Transplantation, Homologous
D007166:Immunosuppressive Agents; D008110:Liver Extracts