title: [Studies on the influence of psychological factors on the immune system: the result of infantile stimulation on the disease course in neonatal mice with bacterial infection].
abstract: NMRI mice of both sexes were, from the first to the tenth day of life, either stimulated by means of handling, or sensorically, or not stimulated at all (the control group). On the tenth day of life, they were separated from their mothers, inoculated intraperitoneally with E.coli O 111 and subsequently subjected to a total deprivation of food and water. The handling-group animals died significantly (1% level) faster than did the sensorically stimulated and the non-treated control group animals. No significant differences could be found in the mortality rates of the last two mentioned groups. After subdividing the animals into five weight classes, a comparative analysis of the three groups showed that the differences in mortality were independent of body weight. The significance of these first animal experiment data on the influence of early experience on the course of infectious diseases in childhood is discussed.
mesh_terms: D000161:Acoustic Stimulation; D000367:Age Factors; D000818:Animals; D001835:Body Weight; D004927:Escherichia coli Infections / Q000276:immunology* / Q000401:mortality; D005260:Female; D006234:Handling, Psychological; D006801:Humans; D007109:Immunity; D008297:Male; D008426:Maternal Deprivation; D008606:Mental Processes; D051379:Mice; D010775:Photic Stimulation; D013315:Stress, Psychological / Q000502:physiology
vernacular_title: Untersuchungen über den Einfluss psychischer Faktoren auf das Immunsystem: Die Wirkung infantiler Stimulation auf den Krankheitsverlauf von bakteriell infizierten Babymäusen