Computed tomography in adrenoleukodystrophy. Correlation of radiological and histological findings.
Computed tomograms (CT) demonstrated symmetrical low-density lesions in the white matter of the posterior portion of the cerebral hemispheres in a 9-year-old boy with adrenoleukodystrophy (Schilder's disease). Biopsy of the brain in an area that appeared normal on the CT scan showed profound loss of myelinated fibers and oligodendroglia; the white matter had been replaced by a rather loose acellular stroma consisting of astroglial cells and blood vessels.
D002648:Child; D003936:Diagnosis, Computer-Assisted; D002549:Diffuse Cerebral Sclerosis of Schilder / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D008297:Male; D014056:Tomography, X-Ray