Effect of amantadine on drug-induced parkisonism: relationship between plasma levels and effect.
Amantadine, administered at a dose of 200 mg/day, antagonized the extapyramidal symptomatology induced by neuroleptic drugs in fifteen psychiatric patients. Steady-state levels were reached within 4-7 days of treatment. Individual plasma levels ranged from 200-900 ng/ml. Apparent plasma half-lives varied from 10-28.5 h with an apparent VD of 200-400 litres. A significant relationship was found between the plasma levels of amantadine and the effects on the extrapyramidal symptomatology. The data suggest a direct effect of amantadine on dopaminergic receptors.
D000328:Adult; D000547:Amantadine / Q000097:blood / Q000627:therapeutic use*; D001682:Biological Availability; D002986:Clinical Trials as Topic; D005260:Female; D006207:Half-Life; D006801:Humans; D008875:Middle Aged; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000188:drug therapy*; D010919:Placebos; D014149:Tranquilizing Agents / Q000009:adverse effects*
D010919:Placebos; D014149:Tranquilizing Agents; D000547:Amantadine