title: Nonsecretory myelomatosis without intracellular immunoglobulin. Immunofluorescent and ultramicroscopic studies.
abstract: A patient with multiple myeloma is reported with severe hypogammaglobulinaemia but without monoclonal immunoglobulin (M-component) in the serum or Bence Jones protein in the urine. In May-Grünwald-Giemsa stained bone marrow film 45% of the cells resembled plasma cells. Marrow immunofluorescent studies showed no increase of immunoglobulin containing cells. Ultrastructural studies showed a large number of cells with a well developed rough endoplasmic reticulum and other morphological features characteristic for plasma cells.
mesh_terms: D001536:Bence Jones Protein / Q000652:urine; D001853:Bone Marrow / Q000276:immunology / Q000648:ultrastructure*; D001854:Bone Marrow Cells; D001859:Bone Neoplasms / Q000276:immunology*; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D008854:Microscopy, Electron; D008875:Middle Aged; D009101:Multiple Myeloma / Q000276:immunology*; D009194:Myeloma Proteins / Q000652:urine
chemical_list: D007136:Immunoglobulins; D009194:Myeloma Proteins; D001536:Bence Jones Protein