[The effect of single and long-term thyrocalcitonin administration on glucose tolerance and insulin secretion].
In male rats, i. m. administration of thyrocalcitonin (TCT)--2 and 10 units/kg for 1, 5, 10 and 15 days, reduced calcium level in the blood serum. In the TCT-treated rats the glucose-tolerance curves after i. p. injection of glucose became diabetoid-like. TCT inhibited the increase of insulin-like activity of the serum after glucose injection. The data suggest that TCT, lowering the calcium content of blood serum, inhibited the glucose-induced secretion of insulin.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D002116:Calcitonin / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000378:metabolism*; D008297:Male; D051381:Rats
D001786:Blood Glucose; D007328:Insulin; D002116:Calcitonin
Vliianie odnokratnogo i dlitel'nogo vvedeniia tirokal'tsitonina na tolerantnost' k gliukoze i sekretsiiu insulina