Effect of azathioprine on the cell cycle of haemopoietic cells.
The megaloblastic erythropoiesis encountered in 3 azathioprine-treated patients with renal transplants was found to be associated with a marked increase in the proportion of early polychromatic erythroblasts in the G2 phase of the cell cycle. By contrast, there was only a slight increase in the proportion of G2 cells in the neutrophil promyelocyte-myelocyte pool of these patients.
D001379:Azathioprine / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D004920:Erythropoiesis; D006412:Hematopoietic Stem Cells / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D016030:Kidney Transplantation; D014184:Transplantation, Homologous
D001379:Azathioprine