A comparison of the antihypertensive effect of atenolol (ICI 66 082) and propranolol.
Propranolol was given to 30 patients with essential hypertension following randomised, double-blind administration of either placebo or a new cardioselective beta-adrenergic receptor antagonist, atenolol (Tenormin, ICI 66 082). Both atenolol and propranolol caused statistically significant reduction of recumbent and erect blood pressure and heart rate. There were no important differences between these variables on comparison of atenolol and propranolol.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001262:Atenolol / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010919:Placebos; D011412:Propanolamines / Q000494:pharmacology*; D011433:Propranolol / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use
D000959:Antihypertensive Agents; D010919:Placebos; D011412:Propanolamines; D001262:Atenolol; D011433:Propranolol