Glucose tolerance and insulin release, a mathematical approach I. Assay of the beta-cell response after oral glucose loading.
From the dose-response relations between glucose and insulin after oral glucose loading, a reproducible parameter for beta-cell response was deduced. The main advantage of this parameter -corrected insulin response, defined as CIR = I- 100/G(G-70)- lies in it independence from the initial or reached glucose level.
D004305:Dose-Response Relationship, Drug; D005947:Glucose / Q000494:pharmacology*; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects*; D008297:Male; D008433:Mathematics; D008954:Models, Biological
D007328:Insulin; D005947:Glucose