Immunization of mice with a mutant of Cryptococcus neoformans. Characterization of the mutant, actively acquired resistance to experimental cryptococcosis in mice.
In 69% of subdermally and 50% of subcutaneously immunized mice, immunity against Cryptococcus neoformans was obtained. The vaccine consisted of a gamma-irradiated mutant, which grew well at 5 degree C and at room temperature. Many subcultures and animal passages did not restore this mutant to the encapsulated, pathogenic wild type.
D000818:Animals; D003453:Cryptococcosis / Q000276:immunology*; D003454:Cryptococcus / Q000276:immunology*; D003455:Cryptococcus neoformans / Q000276:immunology* / Q000472:pathogenicity / Q000528:radiation effects; D007114:Immunization; D051379:Mice; D011830:Radiation Effects; D014612:Vaccines / Q000008:administration & dosage
D014612:Vaccines