title: Oxybutynin in bladder spasm, neurogenic bladder, and enuresis.
abstract: Oxybutynin chloride (Ditropan), a tertiary amine possessing anticholinergic and papaverine-like, direct muscular antispasmodic effects, has been used in controlled clinical studies in patients with neurovesical reflex activity, uninhibited bladders, enuresis, and primary muscle spasm. The cystometrically documented, synergistic, anticholinergic, and muscle relaxant activity of oxybutynin observed in these studies indicates that the drug can be highly effective in the management of reflex neurovesical dysfunction, enuresis, and bladder spasm.
mesh_terms: D000328:Adult; D000588:Amines / Q000627:therapeutic use*; D001626:Bethanechol Compounds; D002648:Child; D002986:Clinical Trials as Topic; D004025:Dicyclomine / Q000627:therapeutic use; D004775:Enuresis / Q000188:drug therapy*; D006801:Humans; D006874:Hydrostatic Pressure; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D010264:Paraplegia / Q000150:complications; D010276:Parasympatholytics / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000188:drug therapy; D011413:Propantheline / Q000627:therapeutic use; D011468:Prostatectomy; D011782:Quadriplegia / Q000150:complications; D012018:Reflex / Q000187:drug effects; D013035:Spasm / Q000188:drug therapy*; D001750:Urinary Bladder, Neurogenic / Q000188:drug therapy*; D014546:Urinary Catheterization / Q000009:adverse effects
chemical_list: D000588:Amines; D001626:Bethanechol Compounds; D010276:Parasympatholytics; D011413:Propantheline; D004025:Dicyclomine