Mutagenicity of malonaldehyde, a decomposition product of peroxidized polyunsaturated fatty acids.
Incubation of histidine requiring auxotrophs of the bacterium Salmonella typhimurium with malonaldehyde, a three-carbon dialdehyde, produced an increased number of revertants in specific strains. Mutagenesis was only observed in frameshift mutants with normal excision repair and did not occur in those base-pair substitution mutants tested. The results are consistent with the cross-linking of bacterial DNA by malonaldehyde leading to mutagenesis expressed through the error-prone repair system.
D005231:Fatty Acids, Unsaturated / Q000378:metabolism*; D008314:Malonates / Q000494:pharmacology*; D008315:Malondialdehyde / Q000494:pharmacology*; D009153:Mutagens; D009154:Mutation; D012486:Salmonella typhimurium / Q000378:metabolism
D005231:Fatty Acids, Unsaturated; D008314:Malonates; D009153:Mutagens; D008315:Malondialdehyde