title: Noninvasive evaluation of cardiovascular effects of preoperative sedation in children.
abstract: The cardiovascular effects of two premedication regimes used in paediatric anaesthesia were studied. Eleven patients received rectal methohexitone (22 mg - kg) and 11 patients received intramuscular Innovar (0.03 ml - kg). The effect of these drugs on ventricular function was evaluated by measuring the shortening of the left ventricular minor dimension by echocardiography. No significant changes in this dimension, blood pressure, heart rate or respiratory rate were demonstrated with either drug. Both rectal methohexitone and intramuscular Innovar were shown to have minimal cardiovascular effects when used as preoperative sedation in paediatric patients. Echocardiography proved to be a valuable technique for the noninvasive evaluation of drug effects on myocardial contractility in children.
mesh_terms: D002648:Child; D002675:Child, Preschool; D004329:Droperidol / Q000494:pharmacology*; D004338:Drug Combinations; D004452:Echocardiography; D005069:Evaluation Studies as Topic; D005260:Female; D005283:Fentanyl / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D008723:Methohexital / Q000494:pharmacology*; D009200:Myocardial Contraction / Q000187:drug effects; D011229:Preanesthetic Medication
chemical_list: D004338:Drug Combinations; C001451:Innovar; D008723:Methohexital; D004329:Droperidol; D005283:Fentanyl