Plasma potassium changes following suxamethonium and suxethonium in normal patients and in patients in renal failure.
Fifty-four healthy patients and 21 patients with chronic renal disease received either suxamethonium 100 mg or suxethonium 150 mg for neuromuscular blockade during endotracheal intubation. A significant increase in plasma potassium concentration was observed following the administration of suxamethonium. No increase occurred in patients who received suxethonium. It is concluded that suxethonium may be preferable to suxamethonium in patients who are at risk from an increase in the plasma potassium concentration.
D000328:Adult; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood*; D008297:Male; D009467:Neuromuscular Depolarizing Agents / Q000494:pharmacology*; D011188:Potassium / Q000097:blood*; D006435:Renal Dialysis; D013390:Succinylcholine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D013997:Time Factors
D009467:Neuromuscular Depolarizing Agents; D013390:Succinylcholine; C013696:suxethonium; D011188:Potassium