title: The spectrum of von Willebrand's disease revisited.
abstract: We have examined nine patients with presumed von Willebrand's disease who present the spectrum of that disorder. Two had findings that would be accepted generally as diagnostic of von Willebrand's disease, and seven had variations of the usual pattern. The commonest variation was the combination of borderline and variable levels of coagulant Factor VIII, commensurate levels of Factor VIII-related antigen, and low levels of ristocetin-Willebrand factor.
mesh_terms: D000293:Adolescent; D000328:Adult; D000941:Antigens; D001777:Blood Coagulation; D001792:Blood Platelets / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005169:Factor VIII / Q000378:metabolism; D005260:Female; D006467:Hemophilia A / Q000175:diagnosis; D006801:Humans; D008297:Male; D008875:Middle Aged; D012310:Ristocetin; D014842:von Willebrand Diseases / Q000097:blood / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology; D014841:von Willebrand Factor / Q000378:metabolism
chemical_list: D000941:Antigens; D014841:von Willebrand Factor; D012310:Ristocetin; D005169:Factor VIII