Preliminary results of oral influenza vaccination with live attenuated viruses.
151 subjects, vaccinated by oral route with live influenza viruses attenuated in the USSR (bivalent  A/England/42/72-B/Hong Kong/5/72 vaccine) and 66 non-vaccinated cohabitants have been studied. The vaccination did not cause any important side effect. The vaccine showed good immunizing activity: HI antibodies appeared in 91% of the subjects initially devoid of antibodies against A type and in 70% against B type. No viral diffusion occurred from the vaccinated to the cohabitants. During an A/Port Chalmers/1/73 epidemic the morbidity (3.3%) among the orally vaccinated patients turned out significantly lower than that among the non-vaccinated cohabitants (12.1%). The protection index was 72.6%.
D000284:Administration, Oral; D000914:Antibodies, Viral / Q000032:analysis; D002986:Clinical Trials as Topic; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007109:Immunity; D009980:Influenza A virus / Q000276:immunology; D007252:Influenza Vaccines / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D007251:Influenza, Human / Q000276:immunology / Q000517:prevention & control; D014613:Vaccines, Attenuated / Q000008:administration & dosage* / Q000009:adverse effects
D000914:Antibodies, Viral; D007252:Influenza Vaccines; D014613:Vaccines, Attenuated