Immune-mediated reactions to althesin (alphaxalone).
Measurements of complement conversion and white cell variations were made on sequential blood samples obtained from a single volunteer following repeated administration of Althesin. The results suggest a mechanism by which a clinically significant hypersensitivity reaction to the drug might be mediated. Studies of patients receiving routine anaesthesia revealed a very high incidence of subclinical "hypersensitivity" reaction, some of which appear to be immune-mediated. These reactions occurred irrespective of whether the patients were induced with Althesin, methohexitone or propanidid.
D000328:Adult; D000530:Alfaxalone Alfadolone Mixture / Q000009:adverse effects*; D002986:Clinical Trials as Topic; D003176:Complement C3 / Q000032:analysis; D003181:Complement C4 / Q000032:analysis; D004342:Drug Hypersensitivity / Q000209:etiology*; D006801:Humans; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D008297:Male; D011277:Pregnanediones / Q000009:adverse effects*
D003176:Complement C3; D003181:Complement C4; D011277:Pregnanediones; D000530:Alfaxalone Alfadolone Mixture