title: Denture stomatitis. The clinical effects of chlorhexidine and amphotericin B.
abstract: The clinical effects of an antibacterial substance with antifungal activity (chlorhexidine) and specific antimycotic (amphotericin B) in denture stomatitis were studied in 100 patients. Five 14-day regimens of chlorhexidine, amphotericin B or placebo lozenges combined with denture immersion in 0.2% chlorhexidine or water were tested. The efficiency of amphotericin B and chlorhexidine was comparable. This indicates that chlorhexidine has a considerable antifungal effect in the oral cavity and, further, that fungi are the responsible micro-organism in denture stomatitis rather than bacteria. Chlorhexidine frequently discloured the dentures. A high incidence of local and general predisposing factors to denture stomatitis, as well as of relapse 14 days after treatment, was observed.
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use*; D001645:Biguanides / Q000627:therapeutic use*; D002710:Chlorhexidine / Q000009:adverse effects / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D004890:Erythema / Q000150:complications; D006801:Humans; D008439:Maxillary Diseases / Q000150:complications; D009181:Mycoses / Q000188:drug therapy; D013280:Stomatitis / Q000188:drug therapy*; D013282:Stomatitis, Denture / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D001645:Biguanides; D000666:Amphotericin B; D002710:Chlorhexidine