title: [Bone marrow insufficiency in the child and androgen therapy. Preliminary results of a prospective schedule of examination and treatment].
abstract: The preliminary results of a prospective study of androgen therapy in the treatment of bone marrow insufficiency in children are reported. This study includes 11 children with the Fanconi syndrome, 21 idiopathic and 3 with toxic aplastic anaemia. Nine patients died early in the course of treatment. Impaired liver function was observed in 28% of patients and virilization in 37% of patients.
mesh_terms: D000293:Adolescent; D000741:Anemia, Aplastic / Q000139:chemically induced / Q000175:diagnosis / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D005199:Fanconi Anemia / Q000188:drug therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008099:Liver / Q000187:drug effects; D008297:Male; D008710:Methenolone / Q000627:therapeutic use; D008777:Methyltestosterone / Q000627:therapeutic use; D010110:Oxymetholone / Q000627:therapeutic use; D045165:Testosterone Congeners / Q000009:adverse effects / Q000627:therapeutic use*; D014770:Virilism / Q000139:chemically induced
chemical_list: D045165:Testosterone Congeners; D008710:Methenolone; D010110:Oxymetholone; D008777:Methyltestosterone
vernacular_title: Insuffisance médullaire de l'enfant et androgénothérapie. Résultats préliminaires d'un protocole prospectif d'exploration et de traitement