Effect of nickel chloride on primary antibody production in the spleen.
Mice immunized intraperitoneally with sheep erythrocytes were treated with nickel chloride, a common particulate air pollutant. Primary antibody production in the spleen was examined using a hemolytic plaque technique. A negative linear dose-response relationship (p is less than 0.05) was observed between the logarithm of (plaques/10(6) cells) and the nickel concentration administered. Mice  injected with 3.09 mug Ni2+/g body weight displayed lymphocyte function similar to that of control mice. However, injection of 9.26-12.34 mug Ni2+/g caused significant immunosupression (p is less than 0.05).
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D003864:Depression, Chemical; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006462:Hemolytic Plaque Technique; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D009532:Nickel / Q000494:pharmacology*; D009929:Organ Size; D012756:Sheep / Q000276:immunology; D013154:Spleen / Q000187:drug effects / Q000276:immunology*; D013997:Time Factors
D009532:Nickel