Kinetics of cis-dichlorodiammineplatinum.
The cancer chemotherapeutic cis-dichlorodiammineplatinum (cis-DDP) was administered to 8 patients (1-hr intravenous infusion) at a dose of 70 mg/m2. Plasma and urine concentrations of platinum were determined by flameless atomic absorption spectrometry. Measured plasma platinum concentrations revealed a biphasic clearance of platinum with half-life values of 23 min and 67 hr. Platinum values obtained 3 wk after the infusion indicated that a third excretory phase might be present. Urinary measurements showed 17 +/- 2.7% of the administered dose excreted in the first 4 hr and 23 +/- 3.9% excreted in the first 24 hr. Renal excretion appears to be predominantly by glomerular filtration. Non-protein-bound plasma platinum values were calculated and the non-protein-bound platinum was found to be rapidly and biphasically cleared from the plasma with half-life values of 8 to 10 min and 40 to 45 min.
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D001943:Breast Neoplasms / Q000188:drug therapy / Q000378:metabolism; D002470:Cell Survival / Q000187:drug effects; D002945:Cisplatin / Q000378:metabolism* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D007939:Leukemia L1210 / Q000473:pathology; D051379:Mice; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000378:metabolism; D010984:Platinum / Q000097:blood / Q000652:urine; D011485:Protein Binding
D001798:Blood Proteins; D010984:Platinum; D002945:Cisplatin