[Pharmacokinetic study of sodium di-n-propylacetate (usual tablet and enteric coated tablet with delayed absorption) (author's transl)].
The authors study the blood levels of DPA after ingestion of the drug in the usual tablet form and after ingestion of an enteric coated tablet with delayed intestinal absorption. They emphasize the fast and very variable absorption of the drug in the usual tablet form which makes necessary the administration of several doses each day. They find a slower absorption from the enteric coated tablet resulting incumulative effects. This form allows an easier administration schedule (one dose in the morning and one dose in the evening). Moreover, the blood levels show less variation during a twenty-four-hour period. Undoubtedly, this new form is an improvement in comparison with the usual tablet.
D000328:Adult; D004334:Drug Administration Schedule; D006801:Humans; D013607:Tablets; D013608:Tablets, Enteric-Coated; D014631:Valerates / Q000008:administration & dosage*; D014635:Valproic Acid / Q000008:administration & dosage* / Q000097:blood / Q000378:metabolism
D013607:Tablets; D013608:Tablets, Enteric-Coated; D014631:Valerates; D014635:Valproic Acid
Etude pharmacocinétique du di-n-propylacétate de sodium sous ses formes ordinaire et retard