title: [Toxicity and tolerance of toxogonin].
abstract: A comparative characteristic of acute toxicity of toxogonine and dipiroxime is given for different animal species with various routes of introduction of the compounds from which it follows that, as concerns the toxicity parameters and the area of toxic action, toxogonine is in the lead. It is also shown that with its multiple administration in a therapeutic dose toxogonine does not affect the peripheral blood, the hepatic and renal functions, the cardio-vascular system, this being also supported by the anatomo-pathological findings. With its intramuscular introduction toxogonine does not produce any local irritation.
mesh_terms: D000818:Animals; D002319:Cardiovascular System / Q000187:drug effects; D002415:Cats; D004285:Dogs; D006168:Guinea Pigs; D007668:Kidney / Q000187:drug effects; D007928:Lethal Dose 50; D008099:Liver / Q000187:drug effects; D051379:Mice; D009768:Obidoxime Chloride / Q000008:administration & dosage / Q000097:blood / Q000633:toxicity*; D010091:Oximes / Q000633:toxicity*; D051381:Rats
chemical_list: D010091:Oximes; D009768:Obidoxime Chloride
vernacular_title: K voprosu o toksichnosti i perenosimosti toksogonina