Induction of labor with prostaglandin E2 administered orally.
The effectiveness of orally administered prostaglandin E2 in inducing labor was studied in 60 patients with uncomplicated, full-term pregnancies, using three dosage schedules. Although 40 patients did deliver, 11 patients' amniotic membranes ruptured at a time considered by the investigators to introduce an undesired variable in attempting to evaluate the drug. Twenty (33%) failed to deliver despite adequate Bishop scores. Side effects were noted in 45% of patients. No significant advantage for induction of labor occurred with the three dosage schedules used.
D000328:Adult; D002986:Clinical Trials as Topic; D003967:Diarrhea / Q000139:chemically induced; D005069:Evaluation Studies as Topic; D005321:Extraembryonic Membranes; D005260:Female; D006801:Humans; D007751:Labor, Induced; D007743:Labor, Obstetric; D011247:Pregnancy; D011458:Prostaglandins E / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D013997:Time Factors; D014839:Vomiting / Q000139:chemically induced
D011458:Prostaglandins E