title: Ascites in patients undergoing maintenance hemodialysis. Report of six cases and physiopathologic approach.
abstract: Six patients with chronic uremia in whom ascites developed during maintenance hemodialysis are described. Their clinical and biochemical findings are reviewed and compared with data of 10 hemodialyzed patients without ascites. Liver cirrhosis was the origin of ascites in only one case. Hypoalbuminemia, liver cirrhosis, congestive heart failure, peritonitis, peritoneal tuberculosis and carcinomatosis were uniformly absent in the other patients. Long-term and marked overhydration seems to be at the origin of ascites. Lack of peripheral edema, probably due to ascites compartmentalization, was a constant finding in every noncirrhotic patient with ascites. When long-term overhydration was stopped after successful kidney transplantation or by means of diminished water and salt ingestion, reversal of the syndrome was attained. Nevertheless, ascites because of liver cirrhosis was not influenced by means of kidney transplantation. In three patients with ascites who did not receive a transplant, a significant reduction in water and salt ingestion was reached after intensive psychotherapy which led to reversal of the ascitic syndrome. In one anephric patient ascites did not develop despite water overloading. Survival has not been influenced by the formation of ascites. Further research is needed to determine the mechanism of sodium transfer across the peritoneal membrane. Influence of humoral factors can be considered, if an active transport mechanism could be demonstrated.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001201:Ascites / Q000150:complications / Q000209:etiology* / Q000503:physiopathology; D001693:Biological Transport, Active; D001826:Body Fluids; D002908:Chronic Disease; D004487:Edema / Q000150:complications; D005260:Female; D006529:Hepatomegaly / Q000150:complications; D006801:Humans; D016030:Kidney Transplantation; D008103:Liver Cirrhosis / Q000150:complications; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000009:adverse effects*; D012964:Sodium / Q000378:metabolism; D014184:Transplantation, Homologous; D014511:Uremia / Q000628:therapy
chemical_list: D012964:Sodium