[Disbalance in the rates of DNA and protein syntheses, occurrence of DNA breaks and viability of cells of rec+-, recA-- and recB--strains of Escherichia coli K-12].
The relationship between the disturbance of the velocity balance (disbalance) of DNA and protein syntheses, the beginning of DNA single-stranded breaks (SB) and their reparation in recA, recB mutants and wild type cells (rec+) is studied. It is found that a strong disbalance of the aforementioned syntheses results in SB of DNA, which are responsible for the death of the cells. The elimination of the disbalance by a balanced inhibition of DNA and protein syntheses contributes to the SB reparation and prevents the cells from the death.
D002470:Cell Survival; D004260:DNA Repair; D004926:Escherichia coli / Q000378:metabolism
Narushenie ravnovesiia skorosteĭ sintezov DNK i belka, vozniknovene razryvov v DNK i zhiznesposobnost' kletok rec+-, recA-- i recB--shtammov Escherichia coli K-12