Dissociation of the early antiproliferative action of methylglyoxal bis(guanylhydrazone) from polyamine depletion. A comparison of the effects of DL-alpha-difluromethyl ormithine and methylglyoxal bis(guanylhydrazone) on the growth of human fibroblasts.
D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured / Q000187:drug effects*; D004247:DNA / Q000096:biosynthesis; D005347:Fibroblasts / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D006146:Guanidines / Q000494:pharmacology*; D006801:Humans; D008935:Mitoguazone / Q000494:pharmacology*; D009952:Ornithine / Q000031:analogs & derivatives* / Q000494:pharmacology; D011073:Polyamines / Q000378:metabolism*; D013937:Thymidine Kinase / Q000378:metabolism
D006146:Guanidines; D011073:Polyamines; D004247:DNA; D009952:Ornithine; D013937:Thymidine Kinase; D008935:Mitoguazone