Role of post-replication and excision repair mechanism in the induction of Trp+ revertants of UV-irradiated Escherichia coli.
Both the post-replication and the excision repair mechanism participate in the induction of Trp+ revertants in Escherichia coli B/r Hcr+ thy trp after a UV-irradiation. At low radiation doses (surviving cell fraction greater than 10(-1) most Trp+ reversions are due to post-replication repair mechanism while at high doses (surviving cell fraction less than 10(-1)) the Trp+ reversions arise probably as the result of an inaccurate excision repair. The absolute accuracy of repair processes decreases with increasing radiation dose.
D004260:DNA Repair; D004269:DNA, Bacterial / Q000032:analysis / Q000378:metabolism* / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D004926:Escherichia coli / Q000032:analysis / Q000378:metabolism* / Q000528:radiation effects; D009154:Mutation; D011830:Radiation Effects; D013941:Thymine / Q000032:analysis; D014364:Tryptophan / Q000096:biosynthesis*; D014466:Ultraviolet Rays
D004269:DNA, Bacterial; D014364:Tryptophan; D013941:Thymine