The bactericidal action of benzoic acid and sodium acetate on the gram-negative flora of dialysis fluid.
Benzoic acid in concentrations from 0.18 per cent and upwards exerted a bactericidal action on the gram-negative flora of dialysis fluid at pH 4.75 in vitro. At a concentration of 0.32 per cent, a reduction of 10(5) was obtained with 24 hours. Sulphonamide resistance did not affect the bactericidal action. The killing effect was hardly more than directly proportional to the concentration of benzoic acid. Increasing inoculum decreased the bactericidal effect. Therefore, benbzoic acid should not be used as an artificial kidney disinfectant when the concentration of microorganisms exceeded 10(5.5)/0.1 ml.
D000085:Acetates / Q000494:pharmacology*; D000333:Aeromonas / Q000187:drug effects; D001419:Bacteria / Q000187:drug effects*; D001565:Benzoates / Q000008:administration & dosage / Q000494:pharmacology*; D002954:Citrobacter / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004352:Drug Resistance, Microbial; D004755:Enterobacteriaceae / Q000187:drug effects; D006801:Humans; D007711:Klebsiella pneumoniae / Q000187:drug effects; D011549:Pseudomonas / Q000187:drug effects; D006435:Renal Dialysis; D013449:Sulfonamides / Q000494:pharmacology; D015003:Yeasts / Q000187:drug effects
D000085:Acetates; D001565:Benzoates; D013449:Sulfonamides