Effect on synthetic capacity of antibodies directed against receptors of allotype-bearing rabbit cells.
Rabbit immunoglobulin molecules possess antigenically distinct allotypic markers. Immunoglobulin molecules possessing such markers which are attached to the surfaces of lymphocyte precursors of antibody-forming cells are believed to serve as antigen receptors. Interactions between allotypic determinants and antibodies directed against them can provide useful models for the study of immunoregulatory phenomena. Exposure of a fetal or neonatal rabbit to antibodies against one of its immunoglobulin allotypes results in a persistent defect in expression of that type (allotype suppression). Some evidence indicates that this phenomenon involves specific active suppression by lymphoid cells. By examining the effects of anti-allotype antibodies on allotype-bearing lymphocytes in vitro, certain specific events surrounding the processes of lymphocyte ontogeny, and the differentiation and maturation of antibody-forming cells are being analyzed.
D000375:Aging; D000818:Animals; D000906:Antibodies; D000937:Antigen-Antibody Reactions; D000961:Antilymphocyte Serum / Q000494:pharmacology; D001666:Binding Sites, Antibody; D005260:Female; D007111:Immunity, Cellular; D007126:Immunoglobulin Allotypes; D007165:Immunosuppression Therapy; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D011817:Rabbits; D013045:Species Specificity
D000906:Antibodies; D000961:Antilymphocyte Serum; D007126:Immunoglobulin Allotypes