Oxypurine excretion during kidney preservation: an indicator of ischaemic damage.
The loss of 5'-adenine nucleotides in ischaemic kidney tissue is related to the postischaemic survival of the organ. It has previously been demonstrated that the catabolism of 5'-adenine nucleotides in ischaemic tissue can be evaluated indirectly by the washout of the final products: hypoxanthine, xanthine, and inosine. The present study indicates a relationship between postischaemic renal function and the duration of normothermic ischaemia. It further demonstrates a linear correlation between the duration of normothermic ischaemia and the quantity of hypoxanthine/xanthine recovered from the perfusate. Thus the method may be used for the evaluation of possible renal grafts.
D000227:Adenine Nucleotides / Q000378:metabolism; D000818:Animals; D005260:Female; D007042:Hypoxanthines / Q000378:metabolism; D007288:Inosine / Q000378:metabolism; D007511:Ischemia / Q000378:metabolism*; D007668:Kidney / Q000098:blood supply / Q000378:metabolism; D016030:Kidney Transplantation; D008297:Male; D009926:Organ Preservation; D010477:Perfusion; D011687:Purines / Q000378:metabolism*; D011817:Rabbits; D013696:Temperature; D014021:Tissue Preservation; D014970:Xanthines / Q000378:metabolism
D000227:Adenine Nucleotides; D007042:Hypoxanthines; D011687:Purines; D014970:Xanthines; D007288:Inosine