The effects of deprivation of prostaglandin precursors on vascular sensitivity to angiotensin II and on the kidney in the pregnant rabbit.
1 Pregnant rabbits were deprived of essential fatty acids from day ten of pregnancy, and results compared with a control group on a normal diet. 2 At term, cannulation of jugular and carotid vessels was performed under anaesthesia, to study the vascular sensitivity to angiotensin II and basal blood pressure. 3 Plasma renin levels, urinary electrolytes and protein were measured. 4 Placental and renal tissue was examined histologically. 5 Though no changes were found in tissues, blood or urine, a markedly significant increase in response to angiotensin II was found in the group deprived of essential fatty acids. This parallels the findings in vascular response in human pre-eclampsia.
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004032:Diet; D004573:Electrolytes / Q000652:urine; D005228:Fatty Acids, Essential / Q000172:deficiency*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D007668:Kidney / Q000033:anatomy & histology / Q000502:physiology*; D011247:Pregnancy; D011270:Pregnancy, Animal; D011453:Prostaglandins / Q000172:deficiency*; D011817:Rabbits; D012083:Renin / Q000097:blood
D004573:Electrolytes; D005228:Fatty Acids, Essential; D011453:Prostaglandins; D000804:Angiotensin II; D012083:Renin