title: Beclomethasone dipropionate aerosol for asthmatic children requiring maintenance oral steroid therapy.
abstract: A single-blind crossover trial comparing beclomethasone dipropionate by inhalation with prednisolone by mouth in the treatment of asthmatic children over a period of 10 months is reported. Fourteen children aged between nine and 16 years entered the trial. All had severe chronic asthma requiring maintenance oral prednisolone therapy in doses ranging from 2 to 7-5 mg/day. Beclomethasone dipropionate given by inhalation in a dose of 400 mug/day was found to be a satisfactory alternative to prednisolone by mouth for controlling the symptoms of asthma. During the course of this trial, three of the children died suddenly during acute exacerbations of asthma. All three had evidence of extensive inflammation of the tracheobronchial tree.
mesh_terms: D000293:Adolescent; D000336:Aerosols; D001249:Asthma / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D001344:Autopsy; D001507:Beclomethasone / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D001980:Bronchi / Q000473:pathology; D002648:Child; D002986:Clinical Trials as Topic; D003645:Death, Sudden; D006801:Humans; D010919:Placebos; D011239:Prednisolone / Q000627:therapeutic use; D014132:Trachea / Q000473:pathology
chemical_list: D000336:Aerosols; D010919:Placebos; D011239:Prednisolone; D001507:Beclomethasone