Phentolamine blocks the somatostatin-mediated inhibition of insulin secretion.
This study was undertaken to determine the influence of alpha-adrenergic blockade upon the somatostatin-mediated inhibition of insulin secretion. Somatostatin inhibited both the basal and glucose-stimulated pancreaticoduodenal vein insulin output of dogs. This effect was not observed during a simultaneous infusion of phentolamine, an alpha-adrenergic blocker. It is proposed that alpha-adrenergic mechanisms play a role in the inhibition of insulin secretion by somatostatin.
D000818:Animals; D001786:Blood Glucose; D003864:Depression, Chemical; D004285:Dogs; D005947:Glucose / Q000378:metabolism; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000378:metabolism; D008297:Male; D010646:Phentolamine / Q000494:pharmacology*; D013004:Somatostatin / Q000037:antagonists & inhibitors* / Q000494:pharmacology
D001786:Blood Glucose; D007328:Insulin; D013004:Somatostatin; D005947:Glucose; D010646:Phentolamine