Inhibited hormonal induction of hepatic phosphoenolpyruvate carboxykinase in poly I: treated mice, an endotoxin-like glucocorticoid antagonism.
Corticosteroid induction of mouse hepatic phosphoenolpyruvate carboxykinase was inhibited by prior injection of poly I:C. Mice challenged with a lethal dose of endotoxin 4 h after administration of poly I: C could not be protected by a concurrent injection of hydrocortisone.
D000818:Animals; D004731:Endotoxins / Q000633:toxicity; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D006854:Hydrocortisone / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D051379:Mice; D010729:Phosphoenolpyruvate Carboxykinase (GTP) / Q000378:metabolism*; D011070:Poly I-C / Q000494:pharmacology*; D012486:Salmonella typhimurium
D004731:Endotoxins; D010729:Phosphoenolpyruvate Carboxykinase (GTP); D011070:Poly I-C; D006854:Hydrocortisone