title: [Characteristics of the interaction of the A-factor with mutant 1439 of Act. streptomycini in the biosynthesis of streptomycin].
abstract: Some peculiar properties of A-factor using by mutant 1439 of Act. streptomycini were studied. It was found that A-factor was most intensively used for biosynthesis of streptomycin when it was added during inoculation. When A-factor was added to a I- or 2-day culture it was required in 10 times higher amounts and its high non-specific adsorption by the mycelium was observed. Interaction of A-factor with the mycelium providing restoration of the biosynthetic process was very rapid on a short-term contat of the I-day culture with A-factor. Transformations occurring under the effect of A-factor and leading to formation of streptomycin took place mainly inside the cells. Changes in the life cycle induced by A-factor developed under different conditions as compared to those promoting streptomycin biosynthesis.
mesh_terms: D001431:Bacteriological Techniques; D003470:Culture Media; D005827:Genetics, Microbial; D008967:Molecular Biology; D009154:Mutation; D013302:Streptomyces / Q000378:metabolism*; D013307:Streptomycin / Q000096:biosynthesis*; D013997:Time Factors
chemical_list: D003470:Culture Media; D013307:Streptomycin
vernacular_title: Osobennosti vazimodeĭstviaa A-faktora s mutantom 1439 Act. streptomycini pri biosinteze streptomitsina