Regulation of immune balance by thymosin: potential role in the development of suppressor T-cells.
Studies in a variety of animal and human models indicate that thymosin plays a role in the differentiation of a number of T-cell subpopulations. The hypothesis presented is that a normal immune balance depends heavily upon the presence of thymosin-activated suppressor or regulator T-cells. A major thrust in our present research program is to determine whether or not the various disorders discussed here are causally related to abnormal thymosin production by the thymus gland. We are also assessing in animal models the potential value of thymsin in the treatment of specific autoimmune diseases. This information may yield new insights for the management of autoimmune type disorders such as SLE. Results from clinical trials to date suggest that thymosin will have a role in boosting the immune responses of patients with specific thymic malfunctions and may indeed exert an influence via the production of suppressor or regulator T-cells.
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology; D002454:Cell Differentiation; D002986:Clinical Trials as Topic; D006689:Hodgkin Disease / Q000188:drug therapy; D006801:Humans; D007104:Immune Adherence Reaction; D007153:Immunologic Deficiency Syndromes / Q000188:drug therapy; D007890:Leiomyosarcoma / Q000188:drug therapy; D007945:Leukemia, Lymphoid / Q000188:drug therapy; D008175:Lung Neoplasms / Q000188:drug therapy; D008545:Melanoma / Q000188:drug therapy; D051379:Mice; D009101:Multiple Myeloma / Q000188:drug therapy; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology; D013947:Thymosin / Q000627:therapeutic use; D013949:Thymus Extracts / Q000627:therapeutic use
D013949:Thymus Extracts; D013947:Thymosin