Restriction in the function of single helper T cells.
T cells involved in specific and nonspecific co-operation belong to a long-lived population. However, under conditions of limiting dilution of T cells it is not a common event to detect both types of co-operative event in a single microculture well. Likewise, as far as specific co-operation is concerned, the simultaneous expression of both direct and indirect PFC responses in a single microculture well is also unusual. Estimates obtained of the number of PFC generated by one T cell in specific co-operation correspond well to those generated by a single B cell; and it would seem that under conditions of the microculture system there is a marked restriction in the number of B cells that a single T cell may interact with in the short term. This restriction seems to be of a one T-cell to one B-cell relationship.
D000818:Animals; D000921:Antibody-Producing Cells; D000961:Antilymphocyte Serum; D001402:B-Lymphocytes / Q000276:immunology; D002999:Clone Cells; D006462:Hemolytic Plaque Technique; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology*; D013934:Thymectomy
D000961:Antilymphocyte Serum