title: Chronic malarial infection in Balb/C mice. Effect on the immune response to sheep erythrocytes and histological changes in the liver and spleen.
abstract: Chronic malarial infection was established in Balb/c mice by following Plasmodium berghei yoelii with P.b. berghei infection. It was found that the IgG plaque-forming cell response to sheep erythrocytes was depressed for at least six months. A preliminary investigation of the histological changes in the spleen and liver is described. The possibility that chronically infected mice could serve as a model for the tropical splenomegaly syndrome is discussed.
mesh_terms: D000818:Animals; D002908:Chronic Disease; D004195:Disease Models, Animal; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D007075:Immunoglobulin M / Q000032:analysis; D008099:Liver / Q000473:pathology*; D008288:Malaria / Q000276:immunology* / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D010962:Plasmodium berghei / Q000276:immunology; D013154:Spleen / Q000473:pathology*
chemical_list: D007075:Immunoglobulin M