The interaction between halofenate and propranolol.
The effect of halofenate on beta adrenergic blockade by propranolol was studied in 4 subjects during chronic drug administration in a randomized, double-blind study. The plasma propranolol concentration was significantly lower during treatment with halofenate than with placebo. The reduction in propranolol levels correlated with a decrease in beta adrenergic blockade. The mechanism for the decrease in plasma concentration has not been determined.
D000328:Adult; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006016:Glycolates / Q000494:pharmacology*; D006218:Halofenate / Q000097:blood / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D010919:Placebos; D011433:Propranolol / Q000097:blood / Q000494:pharmacology*
D006016:Glycolates; D010919:Placebos; D011433:Propranolol; D006218:Halofenate; D007545:Isoproterenol