Prevention of hyaline membrane disease with plasminogen. Preliminary report of a cooperative study.
Five hundred premature infants were treated in a double blind, randomized study with intravenous plasminogen or placebo within 60 minutes of birth. There was a significant decrease in severe clinical respiratory distress, death due to hyaline membrane disease and total mortality in the plasminogen treated infants as compared to the controls.
D002986:Clinical Trials as Topic; D006801:Humans; D006819:Hyaline Membrane Disease / Q000517:prevention & control*; D007231:Infant, Newborn; D007234:Infant, Premature; D010919:Placebos; D010958:Plasminogen / Q000627:therapeutic use*
D010919:Placebos; D010958:Plasminogen