Protein-protein interaction in transport: periplasmic histidine-binding protein J interacts with P protein.
A component of the high-affinity histidine transport system in Salmonella typhimurium, the periplasmic histidine-binding protein J, interacts with another transport component, the P protein. A mutant J protein, with a defective interaction site but intact histidine-binding site, can function in histidine transport if an appropriate compensating mutation is introduced in the P protein. The interaction between the J and P proteins is an obligatory step in transport. The significance of this interaction and of the involvement of the P protein in multiple transport functions is discussed.
D001426:Bacterial Proteins / Q000378:metabolism*; D001665:Binding Sites; D001692:Biological Transport; D002352:Carrier Proteins / Q000378:metabolism*; D005796:Genes; D005816:Genetic Complementation Test; D006639:Histidine / Q000378:metabolism*; D008954:Models, Biological; D009154:Mutation; D011485:Protein Binding; D012486:Salmonella typhimurium / Q000378:metabolism; D013329:Structure-Activity Relationship
D001426:Bacterial Proteins; D002352:Carrier Proteins; D006639:Histidine