The gene dosage effect of the rad52 mutation on X-ray survival curves of tetraploid yeast strains.
The mutation rad52 in the yeast Saccharomyces cerevisiae confers sensitivity to X-rays. The gene dosage effect of this mutation on X-ray survival curves of tetraploid yeast strains is shown. With increasing number of rad52 alleles, both a decrease in the survival for a given dose and a decrease in the survival curve shoulder width are observed. The generation of such a family of survival curves using three different mathematical models is discussed.
D000782:Aneuploidy; D004261:DNA Replication; D005796:Genes; D008954:Models, Biological; D009154:Mutation; D011831:Radiation Genetics; D012441:Saccharomyces cerevisiae / Q000528:radiation effects*; D014965:X-Rays