title: Involvement of the medial hypothalamus and the septal area in the control of food intake and body weight in geese.
abstract: Intracranial injections of 6-OHDA were used to destroy the following brain areas of male geese: bilateral VMH-mamillary (BL-VMH), unilateral VMH (UL-VMH), septal area, and bilateral hypothalamic areas located dorsal, lateral, caudal and rostral to the VMH. The brain damage was nonspecific, destroying cell bodies as well as axons. The effects of these lesions were determined on food intake, body weight, abdominal adipose tissue, liver weight and fat content, and on selected endocrine gland weights. The highest food intake, obesity and liver weight and its fat content were exhibited by the BL-VMH lesioned geese. The UL-VMH and the septal lesioned geese showed moderate increase in food intake, which eventually decreased in the UL-VMH but remained constant in the septal lesioned ones. The liver fat content of the latter groups of geese was higher than the controls. No differences were found between the controls and the group of geese lesioned in the various hypothalamic areas - excluding the VMH - in all parameters measured. While no significant differences were found in pituitary, thyroid and adrenal weights among all groups of geese, a decrease in testes weight was noted in the lesioned groups of geese as compared to the controls. The interrelationships between body weight, food intake, adiposity and liver weight are discussed.
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000033:anatomy & histology / Q000502:physiology*; D005247:Feeding Behavior / Q000187:drug effects; D005777:Geese / Q000502:physiology*; D006892:Hydroxydopamines / Q000494:pharmacology; D007031:Hypothalamus / Q000502:physiology*; D050356:Lipid Metabolism; D008099:Liver / Q000033:anatomy & histology / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011859:Radiography; D012886:Skull / Q000000981:diagnostic imaging; D013238:Stereotaxic Techniques; D013997:Time Factors
chemical_list: D006892:Hydroxydopamines