title: Amide Penicillin Wy-12,556: therapeutic activity in animals subjected to repeated bacterial infection.
abstract: Amide penicillin Wy-12,556 and DBED penicillin were studied for their antibacterial effect in CD-1 mice repeatedly infected with Streptococcus pyogenes C203 and/or Staphylococcus aureus Smith. Animals infected with S. aureus Smith failed to show a difference between the therapeutic activity of DBED penicillin and Wy-12,556. Wy-12,556 was significantly more effective than DBED penicillin in protecting the animals challenged repeatedly with S. pyogenes C203. Wy-12,556 provoked a positive transient chemotactic response in uninfected mice. 24 h after intraperitoneal challenge the exudate showed a high neutrophilic count.
mesh_terms: D000818:Animals; D002452:Cell Count; D004353:Drug Evaluation, Preclinical; D005260:Female; D010401:Penicillin G Benzathine / Q000494:pharmacology / Q000627:therapeutic use*; D010406:Penicillins / Q000494:pharmacology / Q000627:therapeutic use*; D011247:Pregnancy; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013290:Streptococcal Infections / Q000188:drug therapy*; D013297:Streptococcus pyogenes
chemical_list: D010406:Penicillins; D010401:Penicillin G Benzathine