[Phospholipid metabolism in transformed lymphocytes. Molecular mechanism of activation].
An early consequence of lymphocyte stimulation by mitogens is the increased turnover of phospholipid fatty acid moieties. The enzymes catalyzing the selective transfer of fatty acids exhibit a high affinity for highly unsaturated fatty acids. The activation of these acyltransferases leads to a higher content of polyenoic fatty acids and consequently to an increased membrane fluidity.
D008243:1-Acylglycerophosphocholine O-Acyltransferase / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D002794:Choline / Q000378:metabolism; D003208:Concanavalin A / Q000494:pharmacology; D005227:Fatty Acids / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000378:metabolism; D005453:Fluorescence; D037102:Lectins; D008024:Ligands; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000378:metabolism*; D008934:Mitogens; D010713:Phosphatidylcholines / Q000096:biosynthesis; D010743:Phospholipids / Q000378:metabolism*; D011817:Rabbits; D013696:Temperature; D014783:Viscosity
D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D037102:Lectins; D008024:Ligands; D008934:Mitogens; D010713:Phosphatidylcholines; D010743:Phospholipids; D003208:Concanavalin A; D008243:1-Acylglycerophosphocholine O-Acyltransferase; D002794:Choline; D002118:Calcium
Phospholipidstoffwechsel stimulierter Lymphozyten. Untersuchungen zum molekularen Mechanismus der Aktivierung