Synthesis and antimalarial activity of dibenz[c, e]azepine derivatives.
A series of 6-alkyl-2,10-bis(trifluoromethyl)-5H-dibenz-[c,e]azepines were synthesized via a condensation reaction between 5,5'-bis(trifluoromethyl)-2,2'-diformylbiphenyl and the appropriate amine. These compounds were screened for antimalarial activity and were  found to be inactive.
D000818:Animals; D000962:Antimalarials; D002645:Chickens; D003984:Dibenzazepines / Q000138:chemical synthesis / Q000627:therapeutic use; D008288:Malaria / Q000188:drug therapy; D008289:Malaria, Avian / Q000188:drug therapy; D051379:Mice; D010961:Plasmodium; D010962:Plasmodium berghei
D000962:Antimalarials; D003984:Dibenzazepines