Ineffectiveness of lipopolysaccharide for preventing the tolerance induction in bone marrow-derived lymphoid cells with dinitrophenyl-poly-L-(glutamic acid, lysine).
The effect of endotoxin or lipopolysaccharide (LPS) on tolerance induction in bone marrow-derived lymphoid cells (B cells) was investigated. Dinitrophenylated amino acid copolymer-L-(glutamic acid, lysine) (DNP-GL) acts as a potent tolerogen on normal and DNP-primed B cells. LPS significantly enhanced the anti-sheep red blood cell plaque-forming cell (anti-SRBC PFC) response that occurred after the immunization with a low dose of SRBC. LPS did not induce the primary anti-DNP PFC response after the injection of DNP-GL, nor did it prevent the tolerance induction in normal and DNP-primed B cells that occured after the administration of DNP-GL.
D000276:Adjuvants, Immunologic; D000818:Animals; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology*; D004136:Dinitrobenzenes; D005971:Glutamates / Q000276:immunology; D007108:Immune Tolerance; D008070:Lipopolysaccharides / Q000276:immunology*; D008239:Lysine / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D012477:Salmonella enteritidis
D000276:Adjuvants, Immunologic; D004136:Dinitrobenzenes; D005971:Glutamates; D008070:Lipopolysaccharides; D011135:Polysaccharides, Bacterial; D008239:Lysine