Salmonella enteritidis infection in rats: antigens involved in cell-mediated immunity.
When rats are sub-lethally infected with S. entertidis by the intravenous route, there is a period of at least 14 days in which peritoneal exudate cells are unable to migrate from capillary tubes on to glass surfaces; thereafter they migrate as do macrophages from normal animals. The migration of peritoneal cells from rats infected 18-21 days previously is inhibited by lipopolysaccharide (LPS) prepared from homologous and heterologous strains of Salmonella. The apparent non-specificity of LPS activity in the macrophage migration inhibition test has been resolved by demonstrating that lipid A, containing less than 0.01% protein amino acids, is also capable of eliciting this test of cell-mediated immunity.
D000818:Animals; D000942:Antigens, Bacterial; D001202:Ascitic Fluid / Q000166:cytology; D002464:Cell Migration Inhibition; D005260:Female; D007111:Immunity, Cellular; D008055:Lipids / Q000276:immunology; D008070:Lipopolysaccharides / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D011135:Polysaccharides, Bacterial / Q000276:immunology; D051381:Rats; D012480:Salmonella Infections / Q000276:immunology*; D012477:Salmonella enteritidis / Q000276:immunology*
D000942:Antigens, Bacterial; D008055:Lipids; D008070:Lipopolysaccharides; D011135:Polysaccharides, Bacterial