Moniliformin, a metabolite of Fusarium moniliforme NRRL 6322: purification and toxicity.
Fusarium moniliforme NRRL 6322 produced about 600 mg of recoverable moniliformin, a mycotoxic metabolite, per kg of corn grit medium. The moniliformin was extracted from the grits with methanol, purified by preparative thin-layer chromatography, and crystallized from ether. The 50% lethal dose for chicken embryos was 2.8 microgram per egg. For 1-day-old chicks dosed with moniliformin by crop intubation and for female and male mice injected intraperitoneally, the 50% lethal doses were 5.4, 20.9, and 29.1 mg per kg of body weight, respectively. The toxin did not cause a reaction on mouse skin.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D002642:Chick Embryo; D002645:Chickens; D003470:Culture Media; D003503:Cyclobutanes / Q000096:biosynthesis* / Q000302:isolation & purification / Q000633:toxicity; D005260:Female; D005285:Fermentation; D005670:Fusarium / Q000378:metabolism*; D008297:Male; D051379:Mice; D009183:Mycotoxins / Q000096:biosynthesis* / Q000302:isolation & purification / Q000633:toxicity; D012882:Skin Tests; D003313:Zea mays
D003470:Culture Media; D003503:Cyclobutanes; D009183:Mycotoxins; C008539:moniliformin