The reactivity of spleen cells from malarious rats to non-specific mitogens.
The reaction of spleen cells from rats infected with Plasmodium berghei to non-specific mitogens has been measured. The cells have been stimulated in vitro by phytohaemagglutinin, concanavalin-A and by bacterial lypopolysaccharide. In addition the release of lymphocyte activating factor (LAF) by splenic macrophages has been assayed using a heterologous thymocyte culture. The reactivity of spleen lymphocytes from malarious rats is severly affected. The cells do not react either to the T cell-specific mitogens or to the B-cell stimulant. The reactivity of macrophages, as measured by the release of LAF, was not altered by the disease.
D000818:Animals; D002448:Cell Adhesion; D003208:Concanavalin A; D037102:Lectins; D008070:Lipopolysaccharides / Q000276:immunology; D008213:Lymphocyte Activation; D008264:Macrophages / Q000276:immunology; D008288:Malaria / Q000276:immunology*; D008297:Male; D010962:Plasmodium berghei / Q000276:immunology; D051381:Rats; D011917:Rats, Inbred Lew; D013154:Spleen / Q000276:immunology*
D037102:Lectins; D008070:Lipopolysaccharides; D003208:Concanavalin A