title: Evaluation of emotional reactions to oral contraceptive use.
abstract: A review of available clinical studies indicates that 10 to 40 per cent of oral contraceptive users may suffer mild to moderate depression syndromes. Clinical and animal data indicate that a variety of mechanisms may be involved, including alterations in folate, pyridoxine, and vitamine B12 metabolism, as well as related effects on biogenic amine metabolism. Interactive effects may result, such as impairment of usual coping mechnisms and psychological defenses by altered central nervous system function.
mesh_terms: D001205:Ascorbic Acid / Q000378:metabolism; D001679:Biogenic Amines / Q000378:metabolism; D002986:Clinical Trials as Topic; D003276:Contraceptives, Oral / Q000009:adverse effects* / Q000494:pharmacology; D003863:Depression / Q000139:chemically induced; D004305:Dose-Response Relationship, Drug; D004644:Emotions / Q000187:drug effects*; D004967:Estrogens / Q000009:adverse effects; D005260:Female; D005492:Folic Acid / Q000378:metabolism; D006801:Humans; D008297:Male; D011372:Progestins / Q000009:adverse effects; D011736:Pyridoxine / Q000378:metabolism; D012735:Sexual Dysfunction, Physiological / Q000139:chemically induced; D013997:Time Factors; D014801:Vitamin A / Q000378:metabolism; D026681:Vitamin B 6 Deficiency / Q000139:chemically induced
chemical_list: D001679:Biogenic Amines; D003276:Contraceptives, Oral; D004967:Estrogens; D011372:Progestins; D014801:Vitamin A; D005492:Folic Acid; D011736:Pyridoxine; D001205:Ascorbic Acid