Impairment of rosette-forming T lymphocytes in patients with primary intracranial tumors.
The percentage of T lymphocytes that form rosettes (RFC) with sheep erythrocytes (E rosettes), cutaneous delayed-type hypersensitivity, and in vitro lymphocyte transformation was measured in 15 patients with primary intracranial tumors. The ability of T lymphocytes  to  form E rosettes was significantly impaired. These patients also exhibited impaired ability to become sensitized to dinitrochlorobenzene and humoral suppression of PHA-induced lymphocyte blastogenesis. The hypothetical role of antibody(s) to possible shared antigenic determinants on brain and T cells is discussed.
D000328:Adult; D001254:Astrocytoma / Q000276:immunology; D001932:Brain Neoplasms / Q000276:immunology*; D002986:Clinical Trials as Topic; D004137:Dinitrochlorobenzene / Q000276:immunology; D005910:Glioma / Q000276:immunology; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007104:Immune Adherence Reaction; D066298:In Vitro Techniques; D037102:Lectins / Q000494:pharmacology; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D012882:Skin Tests; D013601:T-Lymphocytes / Q000276:immunology*
D004137:Dinitrochlorobenzene; D037102:Lectins