Inhibition of cell wall synthesis by sulfonamides and trimethoprim.
The hypothesis that defective cell wall synthesis seems to represent a final common pathway of drug-induced injury either within the bacterial cell or on its surface was supported by two different findings: (1) sulfamethoxazole and trimethoprim, either alone or in combination, induced morphological findings in various Escherichia coli and Proteus mirabilis strains identical to those found after incubation with so-called cell-wall-active antibiotics (e.g., penicillin) and (2) cell-wall-defective bacteria (L forms, spheroblasts) were resistant to sulfonamides and/or trimethoprim as compared to their normal bacterial cells.
D002473:Cell Wall / Q000187:drug effects*; D003864:Depression, Chemical; D004926:Escherichia coli / Q000187:drug effects* / Q000378:metabolism; D010400:Penicillin G / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000378:metabolism; D013417:Sulfameter / Q000494:pharmacology; D013420:Sulfamethoxazole / Q000494:pharmacology; D013449:Sulfonamides / Q000494:pharmacology*; D014295:Trimethoprim / Q000494:pharmacology*
D013449:Sulfonamides; D013417:Sulfameter; D014295:Trimethoprim; D013420:Sulfamethoxazole; D010400:Penicillin G