Resistance of Shigella dysenteriae type 1 to ampicillin and other antimicrobial agents: strains isolated during a dysentery outbreak in a hospital in Mexico City.
In June 1972, an epidemic of dysentery began in a hospital ward lodging 22 children with tuberculosis. Fifteen of them developed the disease and five children died. The age of the children ranged from five months to four years. A rectal swab culture taken from all hospitalized children three weeks after the initiation of the outbreak revealed Shigella dysenteriae type 1 in five of the patients (28%). The strains isolated were susceptible to cephalothin, gentamicin, kanamycin, colistin, trimethoprim, and nalidixic acid, but were resistant to ampicillin (greater than 5,000 mug/ml), chloramphenicol (300 mug/ml), streptomycin (400 mug/ml), tetracycline (100 mug/ml), and sulfadiazine (1,000 mug per disk). Transfer experiments to Escherichia coli K-12 indicated that these strains were infected with two different plasmids; one was responsible for resistance to chloramphenicol, tetracycline, streptomycin, and sulfonamides, and the other caused resistance to ampicillin. The epidemiological and clinical importance of these findings is emphasized.
D000667:Ampicillin / Q000494:pharmacology*; D002675:Child, Preschool; D002701:Chloramphenicol / Q000494:pharmacology; D003428:Cross Infection / Q000382:microbiology; D004196:Disease Outbreaks; D004405:Dysentery, Bacillary / Q000382:microbiology*; D006801:Humans; D007223:Infant; D008800:Mexico; D010403:Penicillin Resistance; D012762:Shigella dysenteriae / Q000187:drug effects* / Q000302:isolation & purification; D013307:Streptomycin / Q000494:pharmacology; D013449:Sulfonamides / Q000494:pharmacology; D013754:Tetracyclines / Q000494:pharmacology
D013449:Sulfonamides; D013754:Tetracyclines; D002701:Chloramphenicol; D000667:Ampicillin; D013307:Streptomycin