title: Influence of polyunsaturated fatty acids on survival of skin allografts and tumor incidence in mice.
abstract: Subcutaneous or oral administration of the polyunsaturated fatty acid linoleic acid prolongs survival of skin allografts in mice. Mice fed on a diet deficient in polyunsaturated fatty acids show a relative immunopotentiation, as indicated by accelerated skin allograft rejection and decreased incidence and rate of development of methylcholanthrene-induced tumors. These observations support the hypothesis that polyunsaturated fatty acids take part in immunoregulatory mechanisms.
mesh_terms: D000818:Animals; D006084:Graft Rejection / Q000187:drug effects*; D007111:Immunity, Cellular / Q000187:drug effects*; D007156:Immunologic Memory; D008748:Methylcholanthrene; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000276:immunology*; D016038:Skin Transplantation; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D014184:Transplantation, Homologous
chemical_list: D008748:Methylcholanthrene