title: HLA-antigen b27 in cases with joint affections in an outbreak of salmonellosis.
abstract: An outbreak of infection with Salmonella typhi murium occurred in southern Sweden in the summer of 1974. About 330 persons were infected; 91 were hospitalized. 13 of the 91 patients (9 men and 4 women) had symptoms of aseptical polyarthritis. The 13 patients with arthritis were HLA typed with a standard microlymphocytotoxicity test. 13 salmonellosis patients from the same epidemic but without arthritis and 446 healthy blood donors served as controls. Nine (69%) of the 13 patients with arthritis had HLA-B27 compared to 1 (8%) of the control patients and 44 (10%) of the blood donors. The observed association between HLA antigen B27 and reactive arthropathy following salmonella infection could be due to a function of a disease predisposing gene closely linked to HLA-B27.
mesh_terms: D000293:Adolescent; D000328:Adult; D001168:Arthritis / Q000209:etiology / Q000276:immunology*; D005260:Female; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D006801:Humans; D008297:Male; D008875:Middle Aged; D012480:Salmonella Infections / Q000150:complications / Q000276:immunology*; D012486:Salmonella typhimurium
chemical_list: D006680:HLA Antigens; D006649:Histocompatibility Antigens