Polymorphic acetylation of nitrazepam.
Nitrazepam is metabolized in part by nitro-reduction to an amine followed by acetylation. This acetylation step has been shown to be under the control of the same genetic polymorphism as sulphamethazine (syn: sulphadimidine).
D001711:Biotransformation; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008297:Male; D009567:Nitrazepam / Q000378:metabolism* / Q000652:urine; D010641:Phenotype; D011110:Polymorphism, Genetic; D013418:Sulfamethazine / Q000378:metabolism
D013418:Sulfamethazine; D009567:Nitrazepam