Induction of adjuvant arthritis in the rat by various bacterial cell walls and their water-soluble components.
A number of purified cell walls of various gram-positive bacteria had arthritogenic activity in the rat. The water-soluble adjuvant-active component(s), which were isolated from some of these cell walls by utilizing a peptidoglycan-degrading enzyme, did produce severe adjuvant arthritis. However, the components obtained by digestion with glycan-degrading enzymes failed to produce arthritis. Thus, the present finding indicates the importance of a peptidoglycan portion, especially its intact glycan chain, for induction of adjuvant arthritis.
D000818:Animals; D000942:Antigens, Bacterial / Q000008:administration & dosage; D001172:Arthritis, Rheumatoid / Q000209:etiology*; D002473:Cell Wall / Q000276:immunology; D005260:Female; D008970:Molecular Weight; D051381:Rats; D011917:Rats, Inbred Lew; D013211:Staphylococcus aureus / Q000166:cytology; D013291:Streptococcus / Q000166:cytology; D013295:Streptococcus mutans / Q000166:cytology; D013297:Streptococcus pyogenes / Q000166:cytology; D013347:Subcellular Fractions / Q000276:immunology
D000942:Antigens, Bacterial