Multiple lymphonodular cryptococcosis, cured by 5-fluorocytosine.
A 5-year-old boy was admitted with an acute febrile illness and painful and enlarged cervical lymph nodes. A chest X-ray showed right tracheobronchial lymph nodes. A lymph node biopsy demonstrated a tuberculoid appearance, with epitheloid cells, giant cells, and also necrotic zones. Cryptococcus neoformans was isolated both in culture and after animal inoculation. While amphotericin B was not tolerated by the patient, the oral administration of 5-fluorocytosine resulted in a rapid recovery.
D002675:Child, Preschool; D003453:Cryptococcosis / Q000188:drug therapy* / Q000473:pathology; D003455:Cryptococcus neoformans / Q000302:isolation & purification; D003596:Cytosine / Q000031:analogs & derivatives*; D005260:Female; D005437:Flucytosine / Q000627:therapeutic use*; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008206:Lymphatic Diseases / Q000188:drug therapy* / Q000473:pathology
D003596:Cytosine; D005437:Flucytosine