In-vitro effects of Candida albicans of amphotericin B combined with other antibiotics. Preliminary observations.
The effect of amphotericin B combined with rifampicin or doxycycline on growth, oxygen consumption and ATP levels in cultures of Candida albicans, was studied. Alone, neither rifampicin nor doxycycline--even at high concentrations--affected the growth of the test organism. However, when combined with a concentration of amphotericin B which alone did not affect the growth of C. albicans, a pronounced fungistatic effect was obtained with therapeutically attainable concentrations of the drugs.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000666:Amphotericin B / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects*; D004318:Doxycycline / Q000494:pharmacology*; D004357:Drug Synergism; D008826:Microbial Sensitivity Tests; D010101:Oxygen Consumption / Q000187:drug effects; D012293:Rifampin / Q000494:pharmacology*
D000666:Amphotericin B; D000255:Adenosine Triphosphate; D004318:Doxycycline; D012293:Rifampin