Neoplasms in rats and mice fed butylurea and sodium nitrite separately and in combination.
In projected 485-day studies, Fischer 344 rats and C57BL/6 mice were fed 0.58% butylurea and 0.50% sodium nitrite mixed in the diet separately or in combination. The number and type of neoplasms were not significantly increased in either species receiving butylurea or sodium nitrite only. Feeding the two chemicals simultaneously induced neoplasms of the lung, Zymbal's gland, forestomach, intestine and hemopoietic tissues in rats, and malignant lymphomas in mice. The increased incidence of neoplasms in rats and mice fed butylurea and sodium nitrite in combination may result from in vivo formation of the carcinogen, N-butyl-N-nitrosourea.
D000818:Animals; D002273:Carcinogens; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D009573:Nitrites / Q000008:administration & dosage*; D009607:Nitrosourea Compounds / Q000008:administration & dosage* / Q000096:biosynthesis; D051381:Rats; D011916:Rats, Inbred F344; D012977:Sodium Nitrite / Q000008:administration & dosage*; D013997:Time Factors
D002273:Carcinogens; D009573:Nitrites; D009607:Nitrosourea Compounds; D012977:Sodium Nitrite