title: Genetic resistance to marrow transplantation as a leukemia defense mechanism.
abstract: (C57 X AKR) F1 hybrid mice show genetic resistance to C57 parental bone marrow cells, but not to AKR parental bone marrow cells. (C3H X AKR) F1 hybrids show no genetic resistance to bone marrow transplantation from either parental strain. Transplantation of AKR lymphoma cells into lethally irradiated "resistant" (C57 X AKR) F1 and "non-resistant" (C3H X AKR) F1 hybrids produce lymphomatous spleen colonies in "non-resistant" hybrids but not in "resistant" hybrids. Thus "resistant" (C57 X AKR) F1 hybrids can recognize and reject AKR lymphoma cells, but not normal AKR bone marrow cells. A normal biological role of lymphoma surveillance is postulated for genetic resistance.
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D006084:Graft Rejection; D006824:Hybridization, Genetic; D007942:Leukemia, Experimental / Q000235:genetics / Q000276:immunology*; D051379:Mice; D008806:Mice, Inbred AKR; D008810:Mice, Inbred C57BL; D009154:Mutation