[Intraepiploic pancreatic autograft in dogs. Blood sugar changes as compared with a group of pancreatectomized dogs].
The authors used the omentum to envelop thin pancreatic fragments (10 to 18 g. i.e. 1/3 to 1/2 of the canine pancreas). After control of the blood sugar, a total corporo-caudal pancreatectomy was carried out in 21 dogs within 1 to 5 months. Nine survivors from one week to 3 months, permitted them to control the course of the blood sugar with biopsies of the graft and the absence of residual pancreas in the duodeno-hepatic region at autopsy. Compared with a comparative series of 11 dogs which survived total pancreatectomy and required 8 to 22 units of long-acting insulin, the series with autotransplants within the omentum, showed a moderate increase in blood sugar (1,1 to 1,1 g/l). However, progressive or acute cachexia with digestive disorders, frequently fistula of the sub-cutaneous graft were observed. In spite of the progressive and attenuated character of the diabetes, the preservation of secreting endocrine pancreatic islets is only temporary as shown by the histological controls.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D004285:Dogs; D009852:Omentum / Q000601:surgery*; D010179:Pancreas / Q000502:physiology; D016035:Pancreas Transplantation; D010180:Pancreatectomy; D014182:Transplantation, Autologous
D001786:Blood Glucose
Autogreffe pancréatique intraépiploïque chez le chien. Variations de la glycémie par rapport a un groupe d'animaux dépancréatés