Transplantation of tumour with a kidney graft.
A cerebral glioma discovered by angiography and brain biopsy in a kidney donor was subsequently suspected of being a secondary tumour. By this time a biopsy of one of the transplanted kidneys had shown a clump of malignant cells in a glomerulus. Because of the psychological state of this recipient the transplant was not removed, but the recipient of the second kidney was immediately told of the danger of tumour cell transfer, and underwent nephrectomy. The patient remained well on haemodialysis; multiple sectioning of the kidney showed no signs of tumour. The transplant in the first recipient functioned well until his death, six months after operation. At necropsy undifferentiated tumour was found in the pleura, liver, pelvic peritoneum, and transplanted kidney. All cadaver donors should undergo full laparotomy after removal of the kidneys, particularly those with a high risk of cancer, and a full necropsy should also be performed shortly afterwards to exclude tumour and other unsuspected diseases. Then it is not too late to remove a transplanted kidney should a tumour be found.
D000328:Adult; D001344:Autopsy; D001932:Brain Neoplasms / Q000209:etiology; D005910:Glioma / Q000209:etiology; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology / Q000635:transmission*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D014184:Transplantation, Homologous