[131-I capture by the thyroid gland during and after stopping thyrostatic treatment in thyrotoxicosis].
The accumulation of 131J in the thyroid gland was investigate in dynamics in 31 patients with thyrotoxicosis, treated with mercaptoimidazol (timidazol) for an average of 16 months. The patients were clinically euthyroid, with normal values of the basal metabolism, PBI, PBI131 AND TOTAL THYROXIN IN SERUM. The 131J captation, investigated in the course of a maintaining treatment without discontinuation of thyrostatics, show elevated percentages (55.4 per cent by the 6th hour, 61.3 per cent by the 24th hour), being within the norm only in eight patients. Its average values are significantly lower up to the 6th month post treatment discontinuation and closrm, with only 13 above the norm. Only three of them (10 per cent) developed recidivations till the end of the 9th month after e treatment. The authors concluded that thyrostatics, in maintaining doses, do not block thyroid gland 131J cumulation which in the majority of the cases persisted to be elevated a long time after the discontinuation. Its complete normalization in the later stages speak, most probably, for the development of a lasting remission of thyrotoxicosis.
D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy / Q000378:metabolism*; D006993:Hypnotics and Sedatives / Q000627:therapeutic use; D007455:Iodine / Q000378:metabolism*; D007457:Iodine Radioisotopes; D008297:Male; D008713:Methimazole / Q000627:therapeutic use; D008875:Middle Aged; D011433:Propranolol / Q000008:administration & dosage; D012075:Remission, Spontaneous; D013960:Thyroid Function Tests / Q000379:methods; D013961:Thyroid Gland / Q000378:metabolism*; D013963:Thyroid Hormones / Q000008:administration & dosage; D013997:Time Factors
D006993:Hypnotics and Sedatives; D007457:Iodine Radioisotopes; D013963:Thyroid Hormones; D008713:Methimazole; D007455:Iodine; D011433:Propranolol
Kaptatsiiata na 131IJ ot shtitovidnata zhleza po vreme i sled spirane na tireostatichnoto lechenie pri tireotoksikoza