Vesicular pemphigoid.
Seven patients had a chronic eruption of small vesicles that was initially considered to be atypical dermatitis herpetiformis. Histopathologic studies disclosed a subepidermal bulla that was compatible with either bullous pemphigoid or dermatitis herpetiformis. Immunofluorescence studies demonstrated deposition of IgG or C3, Or both, at the basement-membrane zone (BMZ) in six of seven patients. In four patients, circulating BMZ antibodies were detected also. We belive that these cases represent a vesicular form of bullous pemphigoid.
D000328:Adult; D000368:Aged; D000906:Antibodies / Q000032:analysis; D001706:Biopsy; D003176:Complement C3 / Q000032:analysis; D003874:Dermatitis Herpetiformis / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D012872:Skin Diseases, Vesiculobullous / Q000175:diagnosis* / Q000276:immunology
D000906:Antibodies; D003176:Complement C3; D007074:Immunoglobulin G