[Effect of nicotine in pigs (author's transl)].
18 pigs in which venous catheters were positioned for long-term use were injected with nicotine in physiological saline: group 1: 1 mg without anaesthesia; group 2: 1 mg/animal, Hypnodil-anaesthesia; group 3: 0.0143 mg/kg body weight, Hypnodil-anaesthesia. The dose of 1 mg is corresponding to that amount of nicotine contained in the main smoke of a commercially used cigarette. The dose of 0.143 mg/kg body weight is calculated per 1 kg body weight assuming that a man of 70 kg body weight resorbes the total amount of nicotine (1 mg) after maximum inhalation. Application of 1 mg induced the following alterations: sino-auricular block, AV-block of first and second degree, asystolia up to 2 seconds, short decrease in blood pressure and bradycardia as well as flattening and/or inversion and biphasic reaction of T. A longer lasting increase in blood pressure was observed in non-anaesthesized animals. Animals treated with 0.0143 mg/kg body weight showed AV-block of first degree with subsequent extrasystoles. Blood pressure, heart rate and T-wave showed no alterations. Decisive for the induction and extent of acute disturbances seems to be the dose of nicotine. Therefore, a decrease of the nicotine content seems to be indicated toward a "less harmful cigarette".
D000818:Animals; D001835:Body Weight; D001919:Bradycardia / Q000139:chemically induced; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D006323:Heart Arrest / Q000139:chemically induced; D006327:Heart Block / Q000139:chemically induced; D007022:Hypotension / Q000139:chemically induced; D009538:Nicotine / Q000494:pharmacology*; D012848:Sinoatrial Block / Q000139:chemically induced; D012907:Smoking; D013552:Swine
D009538:Nicotine
Die Wirkung von Nikotin beim Schwein