title: Effect of single and multidose cephradine prophylaxis on infectious morbidity of vaginal hysterectomy.
abstract: The administration of cephradine prophylactically to patients who were undergoing vaginal hysterectomies resulted in a marked and significant reduction in the incidence of postoperative infections when compared to a placebo group. Cephradine was the cephalosporin studied because of its unique pharmacodynamic properties, which result in high uterine tissue levels. The protective effect was similar whether 1 g was given preoperatively followed by 500 mg IV q. 6 hours for 4 doses, or a single dose of 2 g IV given approximately 1 hour before surgery. Uterine tissue and serum levels of antibiotic were high and correlated with the degree of protection noted.
mesh_terms: D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D001437:Bacteriuria / Q000453:epidemiology / Q000209:etiology; D002511:Cephalosporins / Q000008:administration & dosage*; D002515:Cephradine / Q000008:administration & dosage* / Q000378:metabolism / Q000627:therapeutic use; D004311:Double-Blind Method; D005260:Female; D005334:Fever / Q000453:epidemiology; D006801:Humans; D007044:Hysterectomy; D007045:Hysterectomy, Vaginal; D008875:Middle Aged; D010388:Pelvis; D010919:Placebos; D011183:Postoperative Complications / Q000453:epidemiology / Q000517:prevention & control*; D011446:Prospective Studies; D014552:Urinary Tract Infections / Q000209:etiology; D014599:Uterus / Q000378:metabolism
chemical_list: D002511:Cephalosporins; D010919:Placebos; D002515:Cephradine