title: [Bumetanide, a new diuretic active during chronic renal failure (author's transl)].
abstract: Bumetanide is a new diuretic, which acts in the ascending limb of Henle's loop. The use of very high doses (5 to 40 mg/24 h) in 32 patients with advanced chronic renal insufficiency gave a clear diuretic effect in half the patients with a creatinine clearance of less than 3 ml/min and in 2/3 of the cases with a creatinine clearance between 3 and 10 ml/min. The efficacy of high doses of bumetanide, as well as their good tolerance shows an action of this new diuretic similar to that of furosemide.
mesh_terms: D000328:Adult; D000368:Aged; D002034:Bumetanide / Q000009:adverse effects / Q000627:therapeutic use*; D002712:Chlorides / Q000652:urine; D002986:Clinical Trials as Topic; D003404:Creatinine / Q000378:metabolism; D004231:Diuresis; D004232:Diuretics / Q000627:therapeutic use*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000188:drug therapy*; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D011188:Potassium / Q000652:urine; D012964:Sodium / Q000652:urine; D014508:Urea / Q000652:urine
chemical_list: D002712:Chlorides; D004232:Diuretics; D002034:Bumetanide; D014508:Urea; D012964:Sodium; D003404:Creatinine; D011188:Potassium
vernacular_title: Le bumétanide, nouveau diurétique actif au cours de l'insuffisance rénale chronique