Hyperbaric oxygenation for severe head injuries. Preliminary results of a controlled study.
60 patients were included in a prospective study to evaluate the effectiveness of hyperbaric oxygenation (OHP) as a treatment of head injury coma. They were assigned to nine subgroups according to age, level of consciousness and eventual neurosurgical procedure, and then selected randomly for OHP or standard therapy. OHP was administered in one or several series of daily exposure at 2.5 ATA. However, the OHP therapy protocol was to be interrupted in 11 cases developing pulmonary, hyperoxic, or infectious complications. Overall mortality and mean duration of coma in survivors were not different in both groups, indicating that OHP was either ineffective or too intermittently applicated. Analysis of results in subgroups revealed that, in one subgroup (18 patients), the rate of recovered consciousness at 1 month was significantly higher when OHP was used. These patients were under 30 and had a brain stem contusion without supratentorial mass lesion. The view is defended that, besides its toxic action on the normal nervous tissue, OHP can counteract edema and ischemia in the zones of brain injuries.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001930:Brain Injuries / Q000628:therapy*; D001933:Brain Stem / Q000293:injuries; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D003128:Coma / Q000628:therapy; D003288:Contusions / Q000628:therapy; D005500:Follow-Up Studies; D006801:Humans; D006931:Hyperbaric Oxygenation; D008875:Middle Aged; D011446:Prospective Studies