title: Radionuclide angiography with 99m technetium-RBCs.
abstract: When properly labeled 99mTc-RBCs are injected into a patient, these labeled cells are fairly stable in the circulation thus allowing scintigraphic studies on cardiovascular system. Among various modified techniques published for 99mTc-RBCs labeling, incubation of RBCs with 99mTc pertechnetate then with tin yielded 99mTc-RBCs most stable in the circulation. Average labeling efficiency of 99mTc-RBCs was 66%. After an injection of about 10 mCi 99mTc-RBCs, clear images of the heart chambers and major vessels could be obtained using a gamma camera. Resolution of vascular structures improved significantly when images were taken using gamma camera equipped with pinhole collimator. Radionuclide angiography with 99mTc-RBCs was very useful in detection of abdominal aortic aneurysm, evaluation of mediastinal mass--thoracic aortic aneurysm, and detection of abnormality in a smaller vessel such as carotid artery. Advantages of this procedure are (1) the technique is simple and noninvasive; (2) it has capability of functional evaluation by obtaining flow study; and (3) multiple and repetitive static views can be obtained even several hours after an injection.
mesh_terms: D000368:Aged; D000784:Aortic Dissection / Q000175:diagnosis; D001012:Aorta, Abdominal; D001014:Aortic Aneurysm / Q000175:diagnosis*; D016122:Brachiocephalic Trunk / Q000002:abnormalities; D002341:Carotid Artery Thrombosis / Q000175:diagnosis; D004912:Erythrocytes; D005260:Female; D006801:Humans; D007553:Isotope Labeling / Q000379:methods; D008297:Male; D008875:Middle Aged; D011829:Radiation Dosage; D011877:Radionuclide Imaging; D013667:Technetium
chemical_list: D013667:Technetium