title: [Preparation and biological trials of antimalarial sulfa embonates].
abstract: With the purpose of obtaining salts of sulfonamides with low toxicity but prolonged action, embonates of seven known sulfonamides, with antimalarila activity, were prepared by double exchange reaction between embonic acid and the antimalarial agents. Six of the seven embonates prepared showed activity against Plasmodium berghei in experimentally infected mice, one of them being significantly more active than the original sulfonamide (sulfadimethoxine).
mesh_terms: D000962:Antimalarials / Q000138:chemical synthesis* / Q000494:pharmacology; D004341:Drug Evaluation; D010962:Plasmodium berghei / Q000187:drug effects; D013449:Sulfonamides / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D000962:Antimalarials; D013449:Sulfonamides
vernacular_title: Preparação e ensaios biológicos de embonatos de sulfas antimaláricas