title: Inhibition of platelet aggregation by cationic protein from polymorphonuclear leukocytes.
abstract: The cationic protein isolated from the granules of neutrophilic polymorphonuclear leukocytes inhibited the aggregation of human platelets as induced by collagen, thrombin, ristocetin, aggregated IgG by approximately 50% and anti-C1q by 75% but had no effect on aggregation-induced by ADP.
mesh_terms: D000244:Adenosine Diphosphate; D000818:Animals; D001798:Blood Proteins / Q000494:pharmacology / Q000502:physiology*; D002097:C-Reactive Protein / Q000378:metabolism; D003094:Collagen; D003172:Complement C1 / Q000378:metabolism; D003174:Complement C1 Inactivator Proteins; D003864:Depression, Chemical; D004563:Electrochemistry; D007074:Immunoglobulin G; D009504:Neutrophils / Q000378:metabolism / Q000502:physiology*; D010447:Peptide Hydrolases / Q000378:metabolism; D010974:Platelet Aggregation / Q000187:drug effects; D012310:Ristocetin; D013917:Thrombin
chemical_list: D001798:Blood Proteins; D003172:Complement C1; D003174:Complement C1 Inactivator Proteins; D007074:Immunoglobulin G; D012310:Ristocetin; D000244:Adenosine Diphosphate; D003094:Collagen; D002097:C-Reactive Protein; D010447:Peptide Hydrolases; D013917:Thrombin