Prolongation of rat heart allograft survival by a synthetic progestogen (melengestrol acetate) and ara-cytidine acylates.
Immunosuppressive effects of newly developed synthetic progestins, melengestrol acetate (MGA), and three pyrimidine analogs, ara-cytidine (Ara-C), Ara-C 5'-benzoate and octanoate, were investigated on the heart allograft survival in the rat. MGA at the dose of 25 mg/kg given every 3rd day starting 1 day before the grafting through day 20 prolonged the graft survival significantly without toxic effects (80.2 +/- 40.2 days versus control 7.0 +/- 0.1 days). The high dose (50 mg/kg/day) was more effective (137.4 +/- 26.6 days) but a high incidence of multiple abscesses (37%) was also noted. The other three agents were either highly toxic or not immunosuppressive.
D000818:Animals; D001565:Benzoates / Q000494:pharmacology / Q000633:toxicity; D002210:Caprylates / Q000494:pharmacology / Q000633:toxicity; D003561:Cytarabine / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000633:toxicity; D006084:Graft Rejection / Q000187:drug effects*; D016027:Heart Transplantation; D008297:Male; D008552:Melengestrol Acetate / Q000494:pharmacology*; D011245:Pregnadienes / Q000494:pharmacology*; D051381:Rats; D011912:Rats, Inbred ACI; D011914:Rats, Inbred BN; D011915:Rats, Inbred BUF; D011917:Rats, Inbred Lew; D013997:Time Factors; D014184:Transplantation, Homologous
D001565:Benzoates; D002210:Caprylates; D011245:Pregnadienes; D003561:Cytarabine; C012190:ara-C 5'-benzoate; D008552:Melengestrol Acetate