title: Clinical study of broncholytic effect and side-effects of isoetharine ('Numotac').
abstract: In thirty-nine adult asthmatics a clinical trial was carried out with 10 mg slow-release tablets of isoetharine ('Numotac', 3M Riker) at two dose levels: 10 mg and 20 mg four times a day. The trial was double-blind with crossover after six weeks. Twenty-three patients reported a positive effect on their respiratory symptoms when isoetharine had replaced their previous treatment; negative effect was reported by one patient while twelve patients were undecided. Tremor was a common side-effect but except in three cases it was slight. There was no difference in side-effects between the high and the low doses if the initial dose was low. However, there were significantly more side-effects when the trial was started with the high dose.
mesh_terms: D000328:Adult; D000368:Aged; D000605:Amino Alcohols / Q000009:adverse effects*; D001249:Asthma / Q000188:drug therapy; D001982:Bronchial Diseases / Q000188:drug therapy*; D001991:Bronchitis / Q000188:drug therapy; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007528:Isoetharine / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D012129:Respiratory Function Tests
chemical_list: D000605:Amino Alcohols; D007528:Isoetharine