Comparison of thrombophlebitis associated with three cephalosporin antibiotics.
A double-blind study with volunteers was performed to determine the incidence and severity of thrombophlebitis associated with cephalothin, cephapirin, cefamandole, and a water control. Although there were no statistical differences in the incidence of thrombophlebitis, cephalothin resulted in significantly more severe thrombophlebitis compared with the other agents.
D002511:Cephalosporins / Q000008:administration & dosage / Q000009:adverse effects*; D002512:Cephalothin / Q000008:administration & dosage / Q000009:adverse effects*; D002514:Cephapirin / Q000008:administration & dosage / Q000009:adverse effects*; D002986:Clinical Trials as Topic; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008333:Mandelic Acids / Q000008:administration & dosage / Q000009:adverse effects; D013924:Thrombophlebitis / Q000139:chemically induced*
D002511:Cephalosporins; D008333:Mandelic Acids; D002514:Cephapirin; D002512:Cephalothin