A controlled trial of phenothiazine withdrawal in chronic schizophrenic patients.
Phenothiazine drugs were withdrawn from 17 chronic schizophrenic in-patients, with a control group of 14 patients remaining on active medication. The trial was conducted under double blind conditions over a period of 42 weeks with weekly assessment of the patients by ward nurses. Of the placebo group 35% relapsed, relapse being related to the level of previous active medication.
D000284:Administration, Oral; D002746:Chlorpromazine / Q000008:administration & dosage* / Q000627:therapeutic use; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004739:England; D006801:Humans; D008297:Male; D008875:Middle Aged; D010919:Placebos; D012008:Recurrence; D012559:Schizophrenia / Q000188:drug therapy*; D012919:Social Behavior / Q000187:drug effects; D012934:Social Isolation / Q000187:drug effects; D013375:Substance Withdrawal Syndrome; D013997:Time Factors
D010919:Placebos; D002746:Chlorpromazine