title: Schizophrenia: a study of genetic models.
abstract: The likelihoods of observing 25 four-generational families of schizophrenics comprising 1,333 individuals have been calculated on the basis of 12 different genetic models and one control 'sporadic' model. The control model gave a log10 likelihood (L), of -240.92. Five of the genetic models were definitely excluded as incompatible with certain pedigrees. The three models with the highest likelihoods were: one locus, the heterozygote having a 10% probability of being classified schizophrenic (L: -220.05); two interacting loci (L:-219.46); and four polygenes (L:-216.87).
mesh_terms: D000483:Alleles; D002874:Chromosome Mapping; D006801:Humans; D008954:Models, Biological; D010375:Pedigree; D011336:Probability; D012559:Schizophrenia / Q000235:genetics*