title: A marked reduction in the incidence of cold haemagglutinin in Plasmodium falciparum malaria.
abstract: A survey of cold haemagglutinin using the normal and tyrpsinized group O red blood cells was performed in 101 normal individuals, 139 individuals with Plasmodium falciparum malaria, 115 individuals with various infections other than malaria and 46 cases of auto-immune haemolytic anaemia. A marked reduction in the incidence of cold haemagglutinin reacting with the normal group O red blood cell was observed in cases of P. falciparum with parasitaemia higher than 100 000/mm3. Although this was also found in other infections, the proposed mechanism seems to be different. Neither remarkable changes in the incidence of cold haemagglutinin reacting with trypsinized red blood cell not the rise of the titres of agglutination in both types of the red blood cells could be detected in P. falciparum malarial cases. The findings are somewhat unexpected and the possible causes are discussed.
mesh_terms: D000373:Agglutinins / Q000032:analysis*; D000744:Anemia, Hemolytic, Autoimmune / Q000276:immunology; D003080:Cold Temperature; D006388:Hemagglutinins / Q000032:analysis*; D006801:Humans; D008288:Malaria / Q000276:immunology* / Q000469:parasitology; D010963:Plasmodium falciparum
chemical_list: D000373:Agglutinins; D006388:Hemagglutinins