title: [Myocarditis and insulitis following coxsackie virus infection].
abstract: We report on the case of a 5 7/12-year-old girl, who presented an acute insulin-dependent diabetes mellitus nineteen days after the operative suture of an atrial septum defect, and who died in a hyperosmolar coma diabeticum in spite of an intensive therapy. At the autopsy there was shown a myocarditis with the histological characteristics of a virus infection. The islet tissue of the pancreas was largely necrotic, the great majority of the islets of Langerhans presented lymphocytic infiltrates. In a neutralisation test against coxsackie-B-viruses (CBV), which was conducted after death, there was found among others an antibody titer of 1:192 against CBV-4. With FITC-marked CBV-antiglobulin, in the islet tissue intracellular CBV-antigen could be proved. It is discussed that virus infections have an etiological importance for the incidence of a so-called juvenile diabetes in man.
mesh_terms: D001344:Autopsy; D002675:Child, Preschool; D003384:Coxsackievirus Infections / Q000150:complications* / Q000473:pathology; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D003926:Diabetic Coma / Q000150:complications; D005260:Female; D006344:Heart Septal Defects, Atrial / Q000601:surgery; D006801:Humans; D007515:Islets of Langerhans / Q000473:pathology; D009205:Myocarditis / Q000209:etiology* / Q000473:pathology; D010195:Pancreatitis / Q000209:etiology* / Q000473:pathology
vernacular_title: Myokarditis und Insulitis nach Coxsackie-Virus-Infekt