[Experimental study of the effect of a number of chemotherapeutic preparations on the intracellular growth of dysentery bacteria, and their interaction with epithelial cells].
The effect of some chemotherapeutics on intercellular growth of Sh. sonnei and their capacity for penetration into cells Hep-2 and primarily triptinized cells of the monkey kidneys was studied. By the character of their effect the drugs were divided into 3 groups. The drugs of the first group, i.e. furazolidone had no effect on intracellular growth of Shigella. The drugs of the second group, i.e. neomycin, monomycin, kanamycin, polymyxin M, ampicillin, negram and 5-NOK induced a rapid decrease in the number of the specimens located inside the cells. The drugs of the third group, i. e. enteroseptol, streptomycin and tetracycline promoted a decrease in the intracellular growth of Shigella by the 3rd-4th day. None of the drugs could be detected inside the cells in the concentrations corresponding to the minimal bacteriostatic ones with respect to Shigella. The activity of the drugs of the second group was connected with their cytotoxicity.
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002478:Cells, Cultured; D003470:Culture Media; D004305:Dose-Response Relationship, Drug; D004847:Epithelial Cells; D004848:Epithelium / Q000382:microbiology*; D008826:Microbial Sensitivity Tests; D012764:Shigella sonnei / Q000187:drug effects* / Q000254:growth & development; D013997:Time Factors
D000900:Anti-Bacterial Agents; D003470:Culture Media
Eksperimental'noe izuchenie vliianiia riada khimioterapevticheskikh preparatov na vnutrikletochnyĭ rost bakteriĭ dizenterii i vzaimodeĭstvie ikh s épitelial'nymi kletkami