title: Antimicrobial effect of four different toothpastes.
abstract: The study was undertaken to evaluate the antimicrobial effect of a commercial toothpaste, claimed to contain active chlorhexidine gluconate. Two traditional toothpastes and a 0.5% chlorhexidine gel were used as negative and positive control pastes. To exclude the effect of mechanical cleaning, all the agents were applied twice daily to the tooth surfaces by means of individually constructed acrylic cap splints. Ten dental students used each paste in a 4-week cross-over double-blind study comprising four test periods of 4 d duration. The students were allowed normal mechanical oral hygiene during the 3 d between the test periods. At the beginning and the end of each test period the tooth surfaces in the right halves of the jaws were scored for the Plaque Index, after which disclosing solution was used and the teeth of the left halves of the jaws were scored for stained plaque. Of all the toothpastes tested, only the chlorhexidine gel exhibited an antimicrobial effect comparable to that of efficient mechanical oral hygiene measures. The effect of the toothpaste with claimed chlorhexidine content did not differ from that of the two traditional toothpastes.
mesh_terms: D001419:Bacteria / Q000187:drug effects*; D001645:Biguanides / Q000494:pharmacology*; D002710:Chlorhexidine / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D003773:Dental Plaque / Q000209:etiology; D003802:Dentifrices / Q000494:pharmacology*; D006801:Humans; D014070:Tooth / Q000382:microbiology; D014100:Toothpastes / Q000494:pharmacology*
chemical_list: D001645:Biguanides; D003802:Dentifrices; D014100:Toothpastes; D002710:Chlorhexidine