title: Some immunologically based reactions that can cause the regression of large tumor masses.
abstract: A widely held view is that the immune reactions of the host directed against tumor-specific membrane antigens can only eliminate a relatively small number of tumor cells. There are, however, some therapeutic maneuvers, that under some conditions can cause the regression of large tumor masses to which immune factors make a critical contribution. Among these are the injection of complement, administration of double stranded RNA and endotoxin, and the induction of inflammation.
mesh_terms: D000818:Animals; D000951:Antigens, Neoplasm; D001500:BCG Vaccine; D003165:Complement System Proteins; D004731:Endotoxins / Q000627:therapeutic use; D006801:Humans; D007109:Immunity; D007167:Immunotherapy; D007938:Leukemia / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D051379:Mice; D009163:Mycobacterium bovis / Q000276:immunology; D009365:Neoplasm Regression, Spontaneous; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000276:immunology* / Q000628:therapy; D012313:RNA / Q000276:immunology; D012878:Skin Neoplasms / Q000628:therapy; D014185:Transplantation, Isogeneic; D014373:Tuberculin
chemical_list: D000951:Antigens, Neoplasm; D001500:BCG Vaccine; D004731:Endotoxins; D014373:Tuberculin; D012313:RNA; D003165:Complement System Proteins