title: Effect of E 600 and Toxobidin on the behavious of cholinesterases in mouse skeletal muscles in the course of experimental trichinellosis.
abstract: Experiments were carried out on mice between the 14th and the 19th day following the infection with Trichinella larvae. E 600 was given in the lowest lethal dose (0-8 mg/kg) and Toxobidin in a curative dose of 15 mg/kg. The activities of AChE and PChE were examined with the use of the substrates of acetylthiocholine and butrylthiocholine iodides (Koelle-Friedenwald's method in Gomori's modification). Toxobidin was found to influence significantly restitution of AChE activity. The mice which had received E 600 under the protection of Toxobidin exhibited but a slight degree of inhibition of AChE activity. However, Toxobidin was not observed to exert a substantial effect on restitution of PChE activity. It is also worthy of note that Toxobidin has a great protective power. No animal died in the experimental group treated with E 600 under the protection  of Toxobidin. On the other hand, in the group which had received E 600 only, all animals died within 10 to 15 minutes.
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D002091:Butyrylcholinesterase / Q000378:metabolism; D002802:Cholinesterases / Q000378:metabolism*; D006651:Histocytochemistry; D051379:Mice; D009132:Muscles / Q000201:enzymology*; D009768:Obidoxime Chloride / Q000494:pharmacology*; D010091:Oximes / Q000494:pharmacology*; D010261:Paraoxon / Q000037:antagonists & inhibitors / Q000633:toxicity*; D014235:Trichinellosis / Q000201:enzymology*
chemical_list: D010091:Oximes; D009768:Obidoxime Chloride; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase; D002802:Cholinesterases; D010261:Paraoxon