Comparison of dantrolene sodium and diazepam in the treatment of spasticity.
The effects of dantrolene sodium and diazepam were compared in a double crossover study of 42 patients with spasticity due to stable multiple sclerosis. Both drugs reduced the findings of spasticity, clonus, and hyperreflexia, and the complaints of muscle stiffness and cramping. Each drug had different side effects which suggest indications and contraindications for its use in spastic patients.
D002986:Clinical Trials as Topic; D003620:Dantrolene / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D003975:Diazepam / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D006827:Hydantoins / Q000627:therapeutic use*; D009103:Multiple Sclerosis / Q000150:complications; D009128:Muscle Spasticity / Q000188:drug therapy* / Q000209:etiology
D006827:Hydantoins; D003620:Dantrolene; D003975:Diazepam