Inhibitory effect of growth hormone on Gross passage A virus-induced thymus leukemia in C3Hf mice.
Administration of ovine growth hormone to young C3Hf mice inhibited Gross passage A virus-induced leukemogenesis as manifested by a delayed onset and a lower incidence of thymus leukemia. These results can be interpreted that growth hormone inhibited thymus-dependent leukemogenesis perhaps through thymotrophic influences which prevented or delayed the thymus involution believed to be essential for leukemia change. In female but not in male Gross passage A virus-infected mice, development of a thymus-independent leukemia appeared to be promoted by growth hormone.
D000406:AKR murine leukemia virus; D000818:Animals; D000831:Animals, Newborn; D005260:Female; D013006:Growth Hormone / Q000494:pharmacology*; D007942:Leukemia, Experimental / Q000209:etiology / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D013950:Thymus Gland / Q000187:drug effects; D013953:Thymus Neoplasms / Q000209:etiology / Q000517:prevention & control*; D014412:Tumor Virus Infections / Q000517:prevention & control
D013006:Growth Hormone