title: Comparison of the pyrogenicity, Limulus activity mitogenicity and complement reactivity of several bacterial endotoxins and related compounds.
abstract: The correlation of mitogenicity, complement activation, pyrogenicity and Limulus amebocyte lysate (LAL) gelation induced by 17 bacterial endotoxins (LPS), modified endotoxins, related compounds, and other B cell mitogens was examined. With the use of these compounds, a significant correlation was found between pyrogenicity and mitogenicity (r = 0.85, p is less than 0.0005), pyrogenicity and LAL reactivity (r = 0.84, p is less than 0.0005), and mitogenicity and LAL reactivity (r = 0.72, p is less than 0.0025). In contrast, complement activation by these compounds did not correlate with mitogenicity, pyrogenicity or LAL reactivity (r = 0.09, p is greater than 0.4; r = -0.17, p is greater than 0.3; r = 0.17, p is greater than 0.3, respectively). These results suggest that a specific chemical configuration may induce mitogenicity, pyrogenicity, and LAL reactivity which differs from that responsible for complement activation.
mesh_terms: D000818:Animals; D001181:Arthropods / Q000276:immunology*; D003165:Complement System Proteins / Q000378:metabolism*; D004731:Endotoxins / Q000494:pharmacology*; D004926:Escherichia coli / Q000276:immunology; D005408:Flagellin / Q000276:immunology; D006168:Guinea Pigs; D006433:Hemocyanins / Q000276:immunology; D006737:Horseshoe Crabs / Q000276:immunology*; D008934:Mitogens / Q000032:analysis*; D011070:Poly I-C / Q000276:immunology; D011749:Pyrogens / Q000032:analysis*; D011817:Rabbits; D012486:Salmonella typhimurium / Q000276:immunology; D014678:Veillonella / Q000276:immunology
chemical_list: D004731:Endotoxins; D008934:Mitogens; D011749:Pyrogens; D005408:Flagellin; D003165:Complement System Proteins; D006433:Hemocyanins; D011070:Poly I-C