C-2801X, a new cephamycin-type antibiotic II. Isolation and characterization.
Two new species of Streptomyces, S. heteromorphus and heteromorphus and S. panayensis, were found to produce a new atibiotic named C-2801X together with cephamycins A and B. The antibiotics were separated from each other by column chromatography on Amberlite XAD-2 and isolated in pure form as mono-sodium salts. C-2801X mono-sodium salt has a molecular formula C25H28N3O12SNa, and exhibits antibacterial activity against Gram-positive and Gram-negative bacteria including those insensitive to cephamycins A and B. From its physicochemical and biological properties, C2801X was considered to be a new cephamycin-type antibiotic.
D000272:Adipates / Q000032:analysis; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D002511:Cephalosporins / Q000032:analysis*; D002513:Cephamycins / Q000032:analysis* / Q000302:isolation & purification / Q000627:therapeutic use; D055598:Chemical Phenomena; D002621:Chemistry; D004927:Escherichia coli Infections / Q000188:drug therapy; D006868:Hydrolysis; D008297:Male; D051379:Mice
D000272:Adipates; D000596:Amino Acids; D002511:Cephalosporins; D002513:Cephamycins