[Change in the sensitivity of dysentery bacteria to certain antibiotics, furazolidone and antifungal preparations when cultured together with Candida albicans].
The effect of Candida albicans (2 collection cultures and 1 freshly isolated culture) on sensitivity of dysentery bacteria (5 Zonne strains, 4 Flexner strains and 2 Newcastle strains) to antibiotics, furazolidone and their combinations with nystatin or decamine was studied by the method of serial dilutions. A total of 937 tests were performed with the use of 10 concentrations in each test. It was found that sensitivity of the Shigella to levomycetin succinate, monomycin and furazolidone decreased in the presence of Candida. Decamine increased the bactericidal effect of furazolidone on Shigella in pure cultures and in addition increased sensitivity of various Shigella species to the antibiotics tested and especially furazolidone when the cultures were grown together with Candida albicans. Nystatin combination with levomycetin succinate and especially with monomycin increased sensitivity of various Shigella species in the presence of Candida albicans. The data are useful in treatment of dysentery since Candida are often isolated from dysentery patients.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects*; D003470:Culture Media; D004338:Drug Combinations; D005664:Furazolidone / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D012760:Shigella / Q000187:drug effects*; D012763:Shigella flexneri / Q000187:drug effects; D012764:Shigella sonnei / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D003470:Culture Media; D004338:Drug Combinations; D005664:Furazolidone
Ob izmenenii chuvstvitel'nosti dizenteriĭnykh bakteriĭ k nekotorym antibiotikam, furazolidonu i protivogribkovym preparatam pri sovmestnom kul'tivirovanii s Candida albicans