[Comparative activity of 6 cephalosporin antibiotics against the causative agents of surgical infection].
Activity of 6 cephalosporanic antibiotics, such as cephaloridin, cephalotin, cephradin, cephacetry1, cephamezin and cephalexin was studied on 200 strains of microorganisms causing purulent infections in surgical patients (Staphylococcus, E. coli, Proteus and Ps. aerugionsa, 50 strains of each organism). The studies showed significant differences in the activity of the above antibiotics against definite species of the pathogenes. The highest activity of the cephalosporins was observed with respect to the clinical strains of staphylococci resistant to such drugs as benzylpenicillin, tetracycline, erythromycin, kanamycin, lincomycin. A significant part of the clinical isolates of gramnegative organisms, i.e. E coli and indol-negative Proteus was characterized by sensitivity to cephalosporins. Among the cephalosporins tested cephaloridin was most active against Staphylococcus, cephacetryl and cephaloridin were most active against E. coli. With respect to the indol-negative Proteus no pronounced advantages of the separate drug were noted. All 6 cephalosporins had low activity against the indol-positive strains of Proteus and all strains of Ps. aeruginosa.
D002505:Cephacetrile / Q000494:pharmacology; D002506:Cephalexin / Q000494:pharmacology; D002509:Cephaloridine / Q000494:pharmacology; D002511:Cephalosporins / Q000494:pharmacology*; D002512:Cephalothin / Q000494:pharmacology; D002515:Cephradine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D011511:Proteus / Q000187:drug effects; D011815:R Factors; D013210:Staphylococcus / Q000187:drug effects; D013530:Surgical Wound Infection / Q000382:microbiology*
D002511:Cephalosporins; D002515:Cephradine; D002505:Cephacetrile; D002509:Cephaloridine; D002506:Cephalexin; D002512:Cephalothin
Sravnitel'naia aktivnost' 6 tsefalosporinovykh antibiotikov v otnoshenii vozbuditeleĭ khirurgicheskoĭ infektsii