Long-acting luteinizing homone-releasing hormone (LH-RH) analogs in the treatment of female infertility.
Induction of ovulation in 20 infertile women was attempted by the use of two synthetic analogs of LH-RH, D-ALA6-Des-Gly10-ethylamide and D-Leu6-Des-Gly10-ethylamide. Ovulation was obtained in five out of the 16 in whom D-Leu6-Des-Gly10-LH-RH ethylamide was administered intramuscularly. Two of the five women received the LH-RH analog additioned of polysaturated gelatines as carrier medium. None of these women got pregnant. It is concluded that better therapeutic results might be expected when a suitable LH-RH vehicle allowing a gradual release of LH-RH analog is obtained.
D000293:Adolescent; D000328:Adult; D005021:Ethylamines / Q000627:therapeutic use; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000032:analysis / Q000627:therapeutic use*; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy*; D007273:Injections, Intramuscular; D010060:Ovulation / Q000187:drug effects*
D005021:Ethylamines; D007987:Gonadotropin-Releasing Hormone