Inhibition of platelet aggregation by cationic protein from polymorphonuclear leukocytes.
The cationic protein isolated from the granules of neutrophilic polymorphonuclear leukocytes inhibited the aggregation of human platelets as induced by collagen, thrombin, ristocetin, aggregated IgG by approximately 50% and anti-C1q by 75% but had no effect on aggregation-induced by ADP.
D000244:Adenosine Diphosphate; D000818:Animals; D001798:Blood Proteins / Q000494:pharmacology / Q000502:physiology*; D002097:C-Reactive Protein / Q000378:metabolism; D003094:Collagen; D003172:Complement C1 / Q000378:metabolism; D003174:Complement C1 Inactivator Proteins; D003864:Depression, Chemical; D004563:Electrochemistry; D007074:Immunoglobulin G; D009504:Neutrophils / Q000378:metabolism / Q000502:physiology*; D010447:Peptide Hydrolases / Q000378:metabolism; D010974:Platelet Aggregation / Q000187:drug effects; D012310:Ristocetin; D013917:Thrombin
D001798:Blood Proteins; D003172:Complement C1; D003174:Complement C1 Inactivator Proteins; D007074:Immunoglobulin G; D012310:Ristocetin; D000244:Adenosine Diphosphate; D003094:Collagen; D002097:C-Reactive Protein; D010447:Peptide Hydrolases; D013917:Thrombin