FSH and LH response to LHRF in Kallman's syndrome.
The olfacto-genital syndrome (Kallman's syndrome) is believed to be primarily an hypothalamic disorder resulting in hypogonadotropic hypogonadism or hypo-ovarianism and anosmia. The pituitary response in 2 patients was measured on dialy subcutaneous injections of 100 mug of LHRF. One of the patients was also studied in a similar fashion by administration of LHRF intravenously for 4 consecutive days. A greater response occurred with the subcutaneous route.
D000328:Adult; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood / Q000502:physiology*; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007006:Hypogonadism / Q000503:physiopathology*; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D007986:Luteinizing Hormone / Q000097:blood / Q000502:physiology*; D008297:Male; D000857:Olfaction Disorders / Q000503:physiopathology*; D010902:Pituitary Gland / Q000503:physiopathology; D013577:Syndrome
D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone