Plasmid-mediated properties of a heat-stable enterotoxin-producing Escherichia coli associated with infantile diarrhea.
The plasmid mediation and transmissibility of heat-stable enterotoxin production and multiple antibiotic resistance have been demonstrated for Escherichia coli O78:K80:H12 epidemiologically incriminated in a hospital outbreak of infantile diarrhea. The conjugal transfer of a 67 X 10(6) - and a 30 X 10(6)-dalton plasmid was associated with the transfer of resistances and enterotoxin production, respectively. Using antibiotics to select E. coli K-12 transconjugants from a one-step bacterial cross, all of the monitored resistances were transferred concurrently, and 36% of the resistant transconjugants produced enterotoxin.
D000818:Animals; D003227:Conjugation, Genetic; D003968:Diarrhea, Infantile / Q000209:etiology; D004768:Enterotoxins / Q000096:biosynthesis*; D004927:Escherichia coli Infections; D005111:Extrachromosomal Inheritance; D006358:Hot Temperature; D006801:Humans; D007223:Infant; D051379:Mice; D008826:Microbial Sensitivity Tests; D010957:Plasmids; D011817:Rabbits
D004768:Enterotoxins