title: Three recessive genes for congenital osteopetrosis in Norway rat.
abstract: In the rat, the autosomal recessive toothless (t1) mutation exhibits an acute form of osteopetrosis. This gene is not an allele of either ia or op that causes respectively, a transitory and acute form of the disease. Comparative radiographic study of t1/t1 and op/op mutants reveals some differences in respect to the size and shape of long bones. In contrast to op/op mutants, homozygous t1/t1 animals failed to respond to either parabiosis or bone marrow transplants.
mesh_terms: D000483:Alleles; D000818:Animals; D005808:Genes, Recessive; D005816:Genetic Complementation Test; D010022:Osteopetrosis / Q000235:genetics / Q000662:veterinary*; D051381:Rats; D012376:Rodent Diseases / Q000235:genetics*