title: Synthesis of 5-substituted aminomethyluracils via the Mannich reaction.
abstract: An extension of the Mannich reaction, in which aminomethylation of the five position of uracil, is reported. Thus, primary and secondary alkylamines and primary aromatic amines containing ring-activating groups led to the title compounds 3-10. Compound 11 in which the aromatic ring contains the ring-deactivating nitro group was synthesized in an alternative way. All compounds were characterized by their elemental and spectral properties.
mesh_terms: D000818:Animals; D002645:Chickens; D007939:Leukemia L1210 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D008288:Malaria / Q000188:drug therapy; D008289:Malaria, Avian / Q000188:drug therapy; D051379:Mice; D010962:Plasmodium berghei; D014498:Uracil / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000627:therapeutic use
chemical_list: D014498:Uracil