Effects of L-thyroxine in acute renal failure.
Eight pediatric patients presenting with acute renal failure (shock kidney, anuria continuing for three to five days) were treated with L-thyroxine (p.o. 5-6 mug per kg per day). Dialysis was not used. Diuresis started within 34 to 46 hours. Serum levels of urea and creatinine normalized within a very short time. The results are discussed on the basis of a new hypothesis concerning the RPF- and GFR-raising action of thyroid hormone in the normal situation and in acute renal failure.
D058186:Acute Kidney Injury / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D003404:Creatinine / Q000097:blood; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D013974:Thyroxine / Q000627:therapeutic use*; D014508:Urea / Q000097:blood
D014508:Urea; D003404:Creatinine; D013974:Thyroxine