The effect of chloramphenicol and sulphaphenazole on the biotransformation of cyclophosphamide in man.
1 The metabolism of cyclophosphamide was investigated before and following treatment with chloramphenicol (five subject) and sulphaphenazole (seven subjects). 2 The biotransformation of cyclophosphamide was retarded after chloramphenicol treatment as indicated by prolongation in the mean serum half-life from 7.5 h to 11.5 h combined with decreased peak activity and integrated concentrations of metabolites. 3 In the sulphaphenazole treated subjects the rate of biotransformation of cyclophosphamide was significantly inhibited in two, unaltered in three and enhanced in two. The inconsistency of the results is discussed.
D000368:Aged; D001711:Biotransformation / Q000187:drug effects; D002701:Chloramphenicol / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D003520:Cyclophosphamide / Q000378:metabolism*; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D008875:Middle Aged; D013426:Sulfaphenazole / Q000494:pharmacology*
D013426:Sulfaphenazole; D002701:Chloramphenicol; D003520:Cyclophosphamide