Embryonic susceptibility of Microtus ochrogaster (common prairie vole) to phenyl mercuric acetate.
Pregnant M. ochrogaster received single intraperitoneal (i.p.) doses of 0.06, 0.125, 0.25, 0.5, 1,2, or 5 mg phenyl mercuric acetate (PMA/kg of body weight on day 8, 9, or 10 of gestation or 0.5 mg PMA/kg on day 7, 8, 9, 10, 11, or 12 of gestation. No toxicity was exhibited, and no abnormal fetuses were observed in any group. An embryocidal effect that depended on dose and stage of development was determined by increased numbers of resorption sites; resorption sites were dose-dependent, and the embryocidal effect decreased as the embryo matured. A dose of 0.06 mg PMA/kg of body weight produced no resorptions when given on day 8 or day 10 of gestation; 0.125 mg/kg produced no resorptions if given on day 10; 0.5 mg/kg resulted in live fetuses and resorptions in the same uterus when given on days 7 through 11; the same dose on day 12 produced all live fetuses; and 1, 2, or 5 mg PMA/kg given on day 8, 9, or 10 of gestation caused total embryo resorption. The i.p. LD50 of PMA in Microtus ochrogaster adult females was 10 mg/kg of body weight.
D000818:Animals; D003411:Arvicolinae / Q000196:embryology*; D004305:Dose-Response Relationship, Drug; D020964:Embryo Loss / Q000139:chemically induced*; D004622:Embryo, Mammalian / Q000187:drug effects; D005260:Female; D005313:Fetal Death / Q000139:chemically induced*; D007928:Lethal Dose 50; D010662:Phenylmercuric Acetate / Q000633:toxicity*; D010663:Phenylmercury Compounds / Q000633:toxicity*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects; D012377:Rodentia / Q000196:embryology*; D013723:Teratogens
D010663:Phenylmercury Compounds; D013723:Teratogens; D010662:Phenylmercuric Acetate