A model for cytoplasm-governed gene regulation.
A model of cytoplasm-governed transcription is presented. The nuclear membrane has a selective permeability towards nuclear pre-mRNA molecules which are provided with group-specific non-translated "passwords". RNA transcription on the chromatin proceeds under a dual control. One of them is gene regulation according to the Britten-Davidson and Georgiev models. The other is cytoplasm-governed regulation mediated through the selective transport of mRNA from nucleus to cytoplasm. Pre-mRNA molecules which are not "in immediate demand" by the cytoplasm and therefore accumulating the nucleus repress their own synthesis by end-product inhibition. The interrelationship of the two types of regulation in the course of cell development is discussed.
D001692:Biological Transport; D002463:Cell Membrane Permeability; D002467:Cell Nucleus; D002843:Chromatin; D003593:Cytoplasm; D008954:Models, Biological; D009693:Nucleic Acid Hybridization; D012333:RNA, Messenger; D014158:Transcription, Genetic
D002843:Chromatin; D012333:RNA, Messenger