Antigen distribution in a latex suspension and its relationship to test sensitivity.
Specific aggregation of latex particles due to antigen-antibody reaction occurred only when antigen was latex bound, as found in a study using Escherichia coli 0111:B4 extract. Maximum serological sensitivity was achieved when free antigen was present in a narrow range of ratios with the bound antigen.
D000327:Adsorption; D000907:Antibodies, Bacterial / Q000032:analysis; D000937:Antigen-Antibody Reactions; D000942:Antigens, Bacterial; D004926:Escherichia coli / Q000276:immunology*; D005069:Evaluation Studies as Topic; D007840:Latex; D007841:Latex Fixation Tests; D008863:Microspheres
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D007840:Latex