title: Etidocaine in retrobulbar anaesthesia. A comparison with mepivacaine.
abstract: A new long-acting local anaesthetic, etidocaine (Duranest) has been compared to mepivacaine (Carbocaine) in retrobulbar anaesthesia in a double-blind trial including 45 patients. Solutions used were etidocaine 0.5% and 1% and mepivacaine 1%, all without adrenaline. The onset time was short and no difference was found between the solutions. The duration of analgesia and motor block was significantly longer with etidocaine 1% compared to mepivacaine 1%. In a following open study with etidocaine 1% and mepivacaine 1% about 80% of the the patients in the etidocaine group never experienced any post-operative pain compared to about 50% in the mepivacaine group. No signs of local or systemic toxicity were noted in the studies.
mesh_terms: D000083:Acetanilides / Q000031:analogs & derivatives; D000328:Adult; D000368:Aged; D000772:Anesthesia, Local; D002387:Cataract Extraction; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D005041:Etidocaine; D005133:Eye Movements; D005901:Glaucoma / Q000601:surgery; D006801:Humans; D008619:Mepivacaine; D008875:Middle Aged; D013508:Ophthalmologic Surgical Procedures; D011183:Postoperative Complications; D013997:Time Factors
chemical_list: D000083:Acetanilides; D008619:Mepivacaine; D005041:Etidocaine