[Protein biosynthesis of the xenogeneic heart during perfusion with the aid of a donor].
Biosynthesis of sarcoplasmic and contractile proteins was studied in cat heart, extracorporeally connected to the rabbit circulation. Biosynthesis of sarcoplasmic proteins was inhibited by 34-40% in ventriculus dexter of the perfused xenogenic heart. Heteroperfusion caused an increased incorporation of 35S-methionine into total proteins of the right auricle and of the interventricular septa and also into contractile proteins of both myocardium ventricles of rabbit-donor. The heteroperfusion did not affect the penetration of the labelled amino acid into various parts of perfused and donor hearts.
D000818:Animals; D002415:Cats; D003285:Contractile Proteins / Q000096:biosynthesis*; D005112:Extracorporeal Circulation; D016027:Heart Transplantation; D008715:Methionine / Q000378:metabolism; D009124:Muscle Proteins / Q000096:biosynthesis*; D009206:Myocardium / Q000378:metabolism*; D011817:Rabbits; D012519:Sarcoplasmic Reticulum / Q000378:metabolism; D013462:Sulfur Radioisotopes; D013997:Time Factors; D014019:Tissue Donors; D014183:Transplantation, Heterologous; D014184:Transplantation, Homologous
D003285:Contractile Proteins; D009124:Muscle Proteins; D013462:Sulfur Radioisotopes; D008715:Methionine
Biosintez belkov ksenogennogo serdtsa pri perfuzii s pomoshch'iu donora