Immunity of the guinea pig's eye after vaccination with Shigella sonnei phase I antigen.
A total of 8 doses, each containing 10(9) live or heated cells of pure phase I antigen of Shigella sonnei and Plesiomonas shigelloides, was administered into the conjunctival sac of guinea pigs during a 3-week period. The eyes were challenged with virulent S. sonnei. The vaccines protected the eyes in 50-80% to the minimum infecting dose andin 20-50% to 3 MID. The peak of immunity began to decrease after the 26th day and on the 56th day it was practically nil. Vaccination caused histological changes in the conjunctiva but not in the cornea.
D000818:Animals; D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; D004405:Dysentery, Bacillary / Q000517:prevention & control*; D014644:Genetic Variation; D006168:Guinea Pigs; D006358:Hot Temperature; D007109:Immunity; D007117:Immunization, Secondary; D007637:Keratoconjunctivitis / Q000517:prevention & control*; D012764:Shigella sonnei / Q000276:immunology*; D014611:Vaccination; D014737:Vibrionaceae / Q000276:immunology
D000942:Antigens, Bacterial; D001428:Bacterial Vaccines