title: Efficacy of repeated pharmacotherapy in experimental acute poisonings with fluostigmine.
abstract: The effectiveness of repeated pharamacotherapy in acute poisonings with fluostigmine was studied in rats. It was demonstrated, that the second i.p. administration of obidoxime (40 mg/kg) was without effect. Repeated i.p. administration of atropine (10 mg/kg) shown marked efficacy only in animals treated previously with atropine (10 mg/kg) and diazepam (2.5 mg/kg). This procedure was without effect in animals treated just after intoxication with atropine (10 mg/kg) or atropine (10 mg/kg) and obidoxime (40 mg/kg). Subsequent administration of diazepam (2.5 mg/kg) or caramiphen (10 mg/kg) was without effect.
mesh_terms: D000818:Animals; D000931:Antidotes; D001285:Atropine / Q000627:therapeutic use; D003517:Cyclopentanes / Q000627:therapeutic use; D003975:Diazepam / Q000627:therapeutic use; D004048:Diethylamines / Q000627:therapeutic use; D007531:Isoflurophate / Q000506:poisoning*; D009768:Obidoxime Chloride / Q000627:therapeutic use; D051381:Rats
chemical_list: D000931:Antidotes; D003517:Cyclopentanes; D004048:Diethylamines; D007531:Isoflurophate; D009768:Obidoxime Chloride; D001285:Atropine; C004519:caramiphen; D003975:Diazepam