Cyclophosphamide pretreatment and protection against malaria.
Mice pretreated with cyclophosphamide were able to overcome infection from a lethal malarial strain. The development of resistance was preceded by increased hypersensitivity to malarial antigens. Hypersensitivity was demonstrable by a delayed footpad swelling technique.
D000818:Animals; D003520:Cyclophosphamide / Q000627:therapeutic use*; D005260:Female; D006968:Hypersensitivity, Delayed / Q000276:immunology; D008288:Malaria / Q000517:prevention & control*; D051379:Mice; D010962:Plasmodium berghei / Q000276:immunology
D003520:Cyclophosphamide