[Allele specificity of the mutator action of bacteriophage T4 genes 43 and 32].
The substitution of tester mutant ri31 (fs-type) for transition mutants rUV30 and rUV48 allowed to reveal new mutator alleles of DNA polymerase gene of phage T4. In these conditions about 70% alleles of this gene were found to be mutators. Unlike experiments carried out with mutant-tester ri31, in experiments with mutants rUV30 and rUV48 the presence of mutator alleles in gene 32 was demonstrated. The transition pathway AT leads to GC is the preferential direction of the mutation alteration under the action of suppressed amber alleles of genes 43 and 32. The data obtained suggest allele specificity of the mutator effect in bacteriophage T4.
D000483:Alleles; D003090:Coliphages; D004259:DNA-Directed DNA Polymerase / Q000096:biosynthesis; D004926:Escherichia coli / Q000201:enzymology; D009154:Mutation; D013489:Suppression, Genetic
D004259:DNA-Directed DNA Polymerase
Allel'-spetsifichnost' mutatornogo deĭstiviia genov 43 i 32 bakteriofaga T4