[Effect of succinic and glutamic acids on the sensitivity of the hypothalamo-gonadotropic system to inhibitory effect of estrogens in old rats].
The daily s. c. injections of 0.58 gamma of stilbestrol to young hemicastrated rats suppressed compensatory hypertrophy (COH), but did not influence COH in old rats. Administration of succinate (i. p. per os or into the 3d brain ventricle) or of glutamate (per os) to old rats restored estogen suppression of COH.
D000375:Aging; D000818:Animals; D002369:Castration; D003864:Depression, Chemical; D004054:Diethylstilbestrol / Q000494:pharmacology*; D004336:Drug Antagonism; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D005971:Glutamates / Q000494:pharmacology*; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors; D006984:Hypertrophy; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects*; D051381:Rats; D013386:Succinates / Q000494:pharmacology*; D013799:Theca Cells / Q000187:drug effects
D005971:Glutamates; D013386:Succinates; D007987:Gonadotropin-Releasing Hormone; D004054:Diethylstilbestrol; D005640:Follicle Stimulating Hormone
Vliianie iantarnoĭ i gliutaminovoĭ kislot na chuvstvitel'nost' gipotalamo-gonadotropnoĭ sistemy k ingibiruiushchemu deĭstviiu estrogenov u starykh krys.