[Experimental study of 2d order tuberculostatic preparations in Mycobacterium bovis resistance to isoniazid or streptomycin (based on the data from a morphological study)].
A comparative study on the therapeutic value of the II line drugs (ethoxide, prothionamide, cycloserin) and bacteriostatics (ethambutol anf rifampicin), with their action upon experimental tuberculosis produced by streptomycin- or isoniazid-resistant mycobacteria of the bovine type, was carried out. This showed rifampicin and ethambutol to be mose effective. Ethoxide and prothionamide proved more efficient when acting upon isoniazid-resistant strains. Cycloserin turned out to be virtually inactive with regard to both streptomycin- and isoniazid-resistant mycobacteria.
D000818:Animals; D000995:Antitubercular Agents / Q000494:pharmacology*; D003523:Cycloserine / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D004977:Ethambutol / Q000494:pharmacology; D007538:Isoniazid / Q000037:antagonists & inhibitors*; D008168:Lung / Q000473:pathology; D051379:Mice; D009164:Mycobacterium Infections / Q000188:drug therapy* / Q000382:microbiology; D009163:Mycobacterium bovis / Q000187:drug effects*; D010670:Phenylthiourea / Q000031:analogs & derivatives* / Q000494:pharmacology; D011515:Prothionamide / Q000494:pharmacology; D012293:Rifampin / Q000494:pharmacology; D013307:Streptomycin / Q000037:antagonists & inhibitors*; D013997:Time Factors
D000995:Antitubercular Agents; D010670:Phenylthiourea; D011515:Prothionamide; D004977:Ethambutol; D003523:Cycloserine; D007538:Isoniazid; D012293:Rifampin; D013307:Streptomycin
Eksperimental'noe izuchenie tuberkulostaticheskikh preparatov vtorogo riada pri ustoĭchivosti mikobakteriĭ bych'ego tipa k izoniazidu ilistreptomitsinu (po dannym morfologicheskogo issledovaniia)