[Heterogeneity of human growth hormone in cultures of pituitary adenomas].
Human growth hormone obtained from cell culture of pituitary adenomas cannot be distinguished from hormone extracted from normal pituitaries as far as the physical, chemical and immunologic characteristics are concerned. From a quantitative point of view the proportion of high molecular weight forms seems greater in the case of the extracted hormone and the intra-cellular hormone than in the case of the hormone secreted in the culture medium. From the biological point of view the hormone obtained from the culture medium seems more active "in vivo" than the extracted hormone. The preliminary results of a compartimental kinetic study suggest a system of two pools of growth hormone with different rates of use.
D000236:Adenoma / Q000378:metabolism*; D046508:Culture Techniques; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D008968:Molecular Conformation; D008970:Molecular Weight; D010902:Pituitary Gland / Q000378:metabolism; D010911:Pituitary Neoplasms / Q000378:metabolism*
D013006:Growth Hormone
Hétérogénéité de l'hormone de croissance humaine dans les cultures d'adénomes hypophysaires