title: [Localization of the site of urinary infection in children by an investigation of antibody-covered bacteria].
abstract: The demonstration by immuno-fluorescence of antibodies on the surface of urinary bacteria, a new method of determining the site of a urinary tract infection, was found to be as valuable in children as it is in adults. A clear correlation exists between a positive test result and renal parenchymal infection on one hand, and a negative result and lower urinary tract infection on the other. Moreover, immunoglobulins were still detectable in original positive urine samples that had been standing at 4degrees C for 7 weeks. The constant finding of IgA on bacteria suggests a particular synthesis for this class of immunoglobulin. A pathophysiologic role for complement would appear to be excluded by the facts that the serum concentrations of C3 were normal and that C3 was invariably absent from the bacterial surface.
mesh_terms: D000293:Adolescent; D000907:Antibodies, Bacterial / Q000652:urine*; D001419:Bacteria / Q000276:immunology* / Q000302:isolation & purification; D002097:C-Reactive Protein / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D003176:Complement C3 / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007070:Immunoglobulin A / Q000652:urine; D007074:Immunoglobulin G / Q000652:urine; D007075:Immunoglobulin M / Q000652:urine; D008297:Male; D013997:Time Factors; D014552:Urinary Tract Infections / Q000175:diagnosis / Q000276:immunology* / Q000382:microbiology; D014556:Urine / Q000382:microbiology
chemical_list: D000907:Antibodies, Bacterial; D003176:Complement C3; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D002097:C-Reactive Protein
vernacular_title: Localisation du site de l'infection urinaire chez l'enfant par la recherche de bactéries recouvertes d'anticorps