title: Genesis of the sweat:plasma urea concentration gradient.
abstract: Experiments with 14C-labeled urea in human volunteers show that urea is sequestered in the epidermis, where it turns over more slowly than in general body water. Sequestered urea, presumed to be concentrated through insensible evaporation of water, is the source of the excess urea found in sweat. Physiologic and clinical implications of the existence of this urea pool are discussed.
mesh_terms: D002986:Clinical Trials as Topic; D006801:Humans; D009132:Muscles / Q000378:metabolism; D012867:Skin / Q000378:metabolism*; D013542:Sweat / Q000378:metabolism*; D013546:Sweating; D014508:Urea / Q000378:metabolism*
chemical_list: D014508:Urea