title: [A prospective study on course and prognostic criteria in "preleukemia" (author's transl)].
abstract: The natural course of disease was followed in 33 patients with so-called preleukemia by a prospective multicentric protocol. Patients with the following criteria were included: Anaemia with granulocytopenia and/or thrombocytopenia, normal or increased cellularity of the bone marrow and exclusion of a known diagnosis of underlying disease. Follow up after assumption of "preleukemia" was 3 years or more. Median survival was 26 months after diagnosis of preleukemia and 36 months after the first unequivocal symptoms of the blood dyscrasia. 40% of the patients changed to the picture of leukemia within 2 years. The most important parameters suggesting subsequent transition to overt leukemia where chromosomal abberations and an increased blast count of the bone marrow.
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000380:Agranulocytosis / Q000503:physiopathology; D000740:Anemia / Q000503:physiopathology; D002648:Child; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007938:Leukemia / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011289:Preleukemia / Q000503:physiopathology*; D011379:Prognosis; D011446:Prospective Studies; D013921:Thrombocytopenia / Q000503:physiopathology
vernacular_title: Verlauf und prognostische Kriterien bei Patienten mit "Präleukämie".