title: UGA mutations and UGA suppressors in yeast.
abstract: Eight UGA alleles have been obtained in S. cerevisiae. Two UGA alleles, ade5,7-143 and gal10-1, were isolated as forward mutations from wildtype. Six UGA alleles, arg4-2' (UGA), his5-2' (UGA), ilv3-1' (UGA), leu2'1' (UGA), lys1-1' (UGA), and asp5-1' (UGA), were derived from UAA alleles by selecting from revertants in the presence of UGA suppressors. With these 8 UGA alleles, two classes of UGA-specific suppressors can be distinguished. Suppressors in one class act upon all 8 allelqs ; while suppressors in the second class act upon all but 3 alleles : ade5,7-143, arg4-2' (UGA), and gal10-1.
mesh_terms: D000227:Adenine Nucleotides; D000483:Alleles / Q000528:radiation effects; D003062:Codon; D005815:Genetic Code; D006150:Guanine Nucleotides; D009154:Mutation / Q000528:radiation effects; D012333:RNA, Messenger; D011831:Radiation Genetics; D012441:Saccharomyces cerevisiae; D013489:Suppression, Genetic; D014466:Ultraviolet Rays; D014500:Uracil Nucleotides
chemical_list: D000227:Adenine Nucleotides; D003062:Codon; D006150:Guanine Nucleotides; D012333:RNA, Messenger; D014500:Uracil Nucleotides