title: Vitamin K and the oral anticoagulant drugs.
abstract: The evolution of vitamin K, from a dietary deficiency in birds to a postribosomal modifier of prothrombin in man, has been a fascinating scientific saga. Its antivitamin, the oral anticoagulant drugs, has been a powerful probe both of vitamin K action and of drug interactions. These agents have emerged from a limbo of clinical therapeutics to become a light of human pharmacology.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000925:Anticoagulants / Q000008:administration & dosage / Q000378:metabolism*; D001241:Aspirin / Q000494:pharmacology; D001463:Barbiturates / Q000494:pharmacology; D001777:Blood Coagulation / Q000187:drug effects; D001779:Blood Coagulation Factors / Q000378:metabolism; D001792:Blood Platelets / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D002792:Cholestyramine Resin / Q000494:pharmacology; D004221:Disulfiram / Q000494:pharmacology; D004232:Diuretics / Q000494:pharmacology; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010653:Phenylbutazone / Q000494:pharmacology; D011516:Prothrombin / Q000378:metabolism; D011955:Receptors, Drug; D014812:Vitamin K / Q000494:pharmacology / Q000502:physiology*; D014859:Warfarin / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D000925:Anticoagulants; D001463:Barbiturates; D001779:Blood Coagulation Factors; D004232:Diuretics; D011955:Receptors, Drug; D002792:Cholestyramine Resin; D014812:Vitamin K; D000431:Ethanol; D014859:Warfarin; D011516:Prothrombin; D010653:Phenylbutazone; D001241:Aspirin; D004221:Disulfiram