Production of migration inhibitory factor in inbred rats.
Strains of genetically inbred rats representative of the known Ag-B groups produced migration inhibitory factor in response to immunization with live bacillus Calmette-Guerin bacilli and intracardiac challenge with old tuberculin; the assays were performed by both in vitro and in vivo methods. None of the strains immunized in this fashion developed delayed hypersensitivity skin reactions to purified protein derivative.
D000818:Animals; D000941:Antigens; D001202:Ascitic Fluid / Q000166:cytology; D001500:BCG Vaccine; D005796:Genes; D007274:Injections, Intraperitoneal; D008263:Macrophage Migration-Inhibitory Factors / Q000096:biosynthesis*; D009163:Mycobacterium bovis / Q000276:immunology; D051381:Rats; D011919:Rats, Inbred Strains / Q000378:metabolism*; D013045:Species Specificity
D000941:Antigens; D001500:BCG Vaccine; D008263:Macrophage Migration-Inhibitory Factors