title: Effect of endotoxin on the peritoneal mast cells in mice.
abstract: Endotoxin administered intraperitoneally has been found to decrease the absolute and relative number of the peritoneal mast cells in mice. The number of peritoneal mast cells showed a dose-dependent biphasic response to endotoxin. Maximal and more consistent decrease in the peritoneal mast cell count was observed at about 24 h and lasted for at least 4 days. Mast cell damage also occurred. The possible mechanism of this phenomenon is discussed.
mesh_terms: D000367:Age Factors; D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology*; D004305:Dose-Response Relationship, Drug; D004731:Endotoxins / Q000494:pharmacology*; D004926:Escherichia coli; D008297:Male; D008407:Mast Cells / Q000187:drug effects*; D051379:Mice; D013997:Time Factors
chemical_list: D004731:Endotoxins