[Substantiation for the kanamycin treatment of certain diseases, taking into account its concentration at the sites of localization of the causative agent (an experimental study)].
Kanamycin concentration in the inflammatory foci was studied on experimental models of pneumonia, maxillary sinusitis and acute dysentery. The kanamycin levels in the sites of the pathogen localization were lower than those in the same tissues of healthy animals. The antibiotic dose should be chosen with the account of its concentration in the focus of the pathogen localization rather than in the blood serum.
D000208:Acute Disease; D000818:Animals; D001702:Biopharmaceutics; D002415:Cats; D004305:Dose-Response Relationship, Drug; D004405:Dysentery, Bacillary / Q000188:drug therapy; D007612:Kanamycin / Q000008:administration & dosage*; D008443:Maxillary Sinus; D009336:Necrosis; D011023:Pneumonia, Staphylococcal / Q000188:drug therapy; D011817:Rabbits; D012763:Shigella flexneri; D012852:Sinusitis / Q000188:drug therapy; D013203:Staphylococcal Infections / Q000188:drug therapy; D013211:Staphylococcus aureus; D013997:Time Factors
D007612:Kanamycin
K obosnovaniiu lecheniia kanamitsinom nekotorykh zabolevaniĭ s uchetom ego kontsentratsii v mestakh lokalizatsii vozbuditelia (éksperimental'noe issledovanie)