Efficacy of a live oral cholera vaccine in human volunteers.
A live attenuated oral cholera vaccine has  been given to volunteers with complete safety. The vaccine strain appeared to multiply significantly in intestinal contents and to result in appreciable vibriocidal antibody response. Subsequent challenge with virulent Inaba vibrios demonstrated substantial protection from clinical illness and from  vibrio shedding. The possibility of reversion to toxin production is discussed.
D000284:Administration, Oral; D000328:Adult; D002771:Cholera / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control; D022121:Cholera Vaccines / Q000008:administration & dosage / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D005243:Feces / Q000382:microbiology; D006801:Humans; D008297:Male; D014613:Vaccines, Attenuated; D014734:Vibrio cholerae / Q000276:immunology* / Q000302:isolation & purification
D022121:Cholera Vaccines; D014613:Vaccines, Attenuated