New synthesis of substituted pyrrolo[1,2-alpha][1,3]diazepine and its pharmacological activity.
A facile route for the synthesis of the substituted pyrrolo[1,2-alpha][1,3]diazepine nucleus from readily available starting material is reported. The compound was tested for antimalarial activity in mice, antineoplastic activity in mice, acute hypotensive activity in rats and dogs, effect on cholesterol-lipoprotein levels in rats, anti-inflammatory activity in rats, antiviral activity in mice, CNS depressant or stimulant activity in mice, diuretic activity in fasted rats, and antidiabetic activity in rats. Hypotensive activity of relatively short duration was observed in rats. The compound lacked positive pharmacological activity in the remaining tests.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000494:pharmacology; D000998:Antiviral Agents / Q000627:therapeutic use; D001381:Azepines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D004232:Diuretics / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000494:pharmacology; D008074:Lipoproteins / Q000097:blood; D008288:Malaria / Q000188:drug therapy; D051379:Mice; D010962:Plasmodium berghei; D011758:Pyrroles / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats
D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D000998:Antiviral Agents; D001381:Azepines; D004232:Diuretics; D007004:Hypoglycemic Agents; D008074:Lipoproteins; D011758:Pyrroles; D002784:Cholesterol