Supplementation of general anaesthesia with narcotic analgesics.
Four analgesic drugs--fentanyl, phenoperidine, morphine and pethidine--were compared in a double-blind trial involving 113 patients paralysed and ventilated with nitrous oxide and oxygen. The differences between the drugs were relatively small. There were only slight differences in "duration of action", a term which is questioned in this context. Pethidine appeared to have a slightly longer duration of action than the other drugs. The problems inherent in studying analgesics in this manner are discussed.
D000328:Adult; D000368:Aged; D000443:Alcuronium / Q000008:administration & dosage; D000700:Analgesics / Q000008:administration & dosage*; D000768:Anesthesia, General; D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D004338:Drug Combinations; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage; D006801:Humans; D007977:Levallorphan / Q000008:administration & dosage; D008297:Male; D008614:Meperidine / Q000008:administration & dosage; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage; D009294:Narcotics / Q000008:administration & dosage*; D010638:Phenoperidine / Q000008:administration & dosage; D013997:Time Factors
D000700:Analgesics; D004338:Drug Combinations; D009294:Narcotics; D007977:Levallorphan; D009020:Morphine; D008614:Meperidine; D010638:Phenoperidine; D000443:Alcuronium; D005283:Fentanyl