title: Evidence for a selective cytotoxic effect of carrageenan on cells of the immune system in vivo and in vitro.
abstract: Carrageenan suppressed antibody production to sheep erythrocytes in the mouse only when injected together with or 24 h prior to antigen. Pretreatment of sensitized spleen cell cultures with carrageenan reduced the degree of stimulation obtained using antigen but not PHA.
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D002351:Carrageenan / Q000494:pharmacology*; D003601:Cytotoxicity Tests, Immunologic; D004912:Erythrocytes / Q000276:immunology*; D006462:Hemolytic Plaque Technique; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D051379:Mice; D013154:Spleen / Q000166:cytology; D013997:Time Factors
chemical_list: D007075:Immunoglobulin M; D002351:Carrageenan