Suramin stimulates B-lymphocyte proliferation in the mouse.
Suramin, a drug against trypanosomiasis and onchocerciasis, stimulates in vitro mouse B-lymphocytes to transform into blastcells, to incorporate 3H-thymidine and to go into mitosis. Thymus cells (hydro-cortisone-sensitive or resistant) do not respond whereas cells from homozygous nude mice are stimulated. The large majority of the blast-cells have surface immunoglobulins, and the proportion of cells with intracellular immunoglobulin increases during the course of the cultures.
D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects*; D002478:Cells, Cultured; D005455:Fluorescent Antibody Technique; D006854:Hydrocortisone / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D008819:Mice, Nude; D008938:Mitosis / Q000187:drug effects; D013154:Spleen; D013268:Stimulation, Chemical; D013498:Suramin / Q000494:pharmacology*; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors
D013498:Suramin; D013936:Thymidine; D006854:Hydrocortisone