Mutagenicity and possible carcinogenicity of hair colourants and constituents.
Skin painting experiments showed that two semi-permanent hair colorants applied at low concentrations caused an early appearance of tumours in two strains of mice. Both colorants were mutagenic in S. typhimurium and further investigation revealed that three categories of hair colorant contained mutagenic constitutents.
D000814:Aniline Compounds / Q000494:pharmacology; D000818:Animals; D001391:Azo Compounds / Q000009:adverse effects; D004396:Coloring Agents / Q000009:adverse effects / Q000378:metabolism; D003358:Cosmetics / Q000009:adverse effects* / Q000378:metabolism / Q000494:pharmacology; D006200:Hair Color / Q000187:drug effects*; D008099:Liver / Q000378:metabolism; D051379:Mice; D009154:Mutation / Q000187:drug effects*; D009596:Nitrophenols; D010655:Phenylenediamines / Q000009:adverse effects; D012486:Salmonella typhimurium / Q000187:drug effects; D012878:Skin Neoplasms / Q000139:chemically induced*; D013997:Time Factors
D000814:Aniline Compounds; D001391:Azo Compounds; D004396:Coloring Agents; D003358:Cosmetics; D009596:Nitrophenols; D010655:Phenylenediamines