title: Relationship between antidepressant effect and plasma level of nortriptyline. Clinical studies.
abstract: Strong evidence has been found for the assumption that NT inhibits its own antidepressive effect at high, but non toxic plasma levels in patients suffering from endogenous depression. Based on three investigations we will recommend an optimal therapeutic plasma range for NT between 50 and 150 ng NT/ml.
mesh_terms: D003863:Depression / Q000188:drug therapy; D006801:Humans; D009661:Nortriptyline / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D009661:Nortriptyline