Bacteriological status (point prevalence) of lepromatous outpatients under sulfone treatment.
The study concerns 337 outpatients with lepromatous leprosy who had been receiving dapsone treatment for 1-26 years-69% of them regularly and 31% irregularly. Routine bacterial examination (10 min per slide) by a paramedical technician showed only 50% of these patients to be bacteriologically positive. This rate attained 99% when each slide was examined for 30-60 min by a qualified bacteriologist. Other factors-apart from the limited action of sulfones-might account for these unexpected results: the material was collected by an experienced leprologist; the disease was still clinically active in 75% of the patients; about 25% of them had been treated for only 1-4 years; and the intake of dapsone in long-term treatment gradually decreases.
D006801:Humans; D007918:Leprosy / Q000188:drug therapy / Q000382:microbiology*; D009166:Mycobacterium leprae / Q000302:isolation & purification*; D009297:Nasal Mucosa / Q000382:microbiology; D012867:Skin / Q000382:microbiology; D013450:Sulfones / Q000627:therapeutic use*
D013450:Sulfones