Bacterial endotoxin and impaired fetal development.
Small doses of E. coli endotoxin given to pregnant mice on the 13th day of pregnancy caused only a mild maternal illness but induced resorption of approximately half the number of fetuses in each mouse. The remaining live fetuses developed normally and showed no evidence of retarded growth or malformations. The weights of their placentas and maternal spleens increased significantly. Endotoxin given on the 6th day of pregnancy caused a small reduction in fetal weights.
D000818:Animals; D004731:Endotoxins / Q000494:pharmacology*; D004926:Escherichia coli; D005247:Feeding Behavior; D005260:Female; D005313:Fetal Death; D005327:Fetal Resorption; D005333:Fetus / Q000502:physiology*; D006128:Growth / Q000187:drug effects; D051379:Mice; D009929:Organ Size; D010920:Placenta / Q000187:drug effects; D011247:Pregnancy; D013154:Spleen / Q000187:drug effects
D004731:Endotoxins