title: Rejection of sarcoma cells at the site of an inflammatory reaction: macrophages are not the only effector cells.
abstract: Purified protein derivative (PPD) (a soluble protein from tubercle bacilli), when injected together with sarcoma cells into syngeneic mice that had been immunized previously with Bacillus Calmitte-Guérin (BCG), prevents tumour toxic to sarcoma cells [4]. However, non-adherent mononuclear peritoneal exudate cells from BCG-treated mice were also found on addition of PPD to become cytotoxic to sarcoma cells. In vivo assays indicate that such cells may play a major role in the in vivo destruction of tumours at the site of a delayed hypersensitivity reaction.
mesh_terms: D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology / Q000276:immunology; D001500:BCG Vaccine; D003601:Cytotoxicity Tests, Immunologic; D005354:Fibrosarcoma / Q000276:immunology*; D006084:Graft Rejection; D007249:Inflammation / Q000276:immunology; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D009000:Monocytes / Q000276:immunology*; D009163:Mycobacterium bovis / Q000276:immunology; D009368:Neoplasm Transplantation; D012513:Sarcoma, Experimental / Q000276:immunology; D014185:Transplantation, Isogeneic; D014373:Tuberculin / Q000008:administration & dosage
chemical_list: D001500:BCG Vaccine; D014373:Tuberculin