Protein synthesis and secretion in the cobalt chloride damaged exocrine pancreas of guinea pigs. An electron microscopic-autoradiographical and histochemical study.
The cobalt chloride induced disturbance of secretion in the pancreatic acinar cells of guinea pigs consists, on the one hand, in a continued but reduced synthesis of exportable enzyme proteins, on the other hand in an alteration of both function and structure of the Golgi apparatus and the mitochondriae, followed by a loss of zymogen granules and the occurence of numerous intracisternal granules. The latter are transported through the cisternae of the endoplasmic reticulum to the apical cell pole and discharged into the lumen of the acinus without any interposition of the Golgi apparatus.
D000818:Animals; D001345:Autoradiography; D003035:Cobalt / Q000009:adverse effects*; D006168:Guinea Pigs; D006651:Histocytochemistry; D007515:Islets of Langerhans / Q000187:drug effects; D008297:Male; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D010182:Pancreatic Diseases / Q000139:chemically induced; D014176:Protein Biosynthesis; D011506:Proteins / Q000378:metabolism*
D011506:Proteins; D003035:Cobalt