Chloroquine sensitivity of Plasmodium falciparum in Ethiopia. I. Results of an in vivo test.
The in vivo response of Plasmodium falciparum to the WHO single test dose (10 mg/kg body weight) of chloroquine base was examined in Ethiopia at four localities where malaria was meso- or hyperendemic. Parasitemias cleared by the 3rd day after chloroquine administration in all of the 150 test subjects. No recrudescences were detected during the 6-day or 11-day follow-up periods. The value of the in vivo test was severely limited by the inability to quarantine subjects and follow them for the 28-day period recommended by the World Health Organization.
D002738:Chloroquine / Q000627:therapeutic use*; D004352:Drug Resistance, Microbial; D005002:Ethiopia; D008288:Malaria / Q000188:drug therapy* / Q000209:etiology; D008826:Microbial Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000302:isolation & purification
D002738:Chloroquine