Depression of lymphocyte response to concanavalin A in rabbits infected with Treponema pallidum (Nichols strain).
Peripheral blood lymphocytes isolated from rabbits in the early stages of Treponema pallidum infection responded poorly when exposed to concanavalin A in vitro. Maximal depression of blastogenesis occurred when lymphocytes were cultured in the presence of autologous serum in comparison with fetal calf or normal homologous rabbit serum.
D000818:Animals; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology*; D007106:Immune Sera; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D011817:Rabbits; D013587:Syphilis / Q000276:immunology*; D014210:Treponema pallidum / Q000276:immunology*
D007106:Immune Sera; D003208:Concanavalin A