Prolongation of allografts in animals with a new agent: tilorone.
Tilorone, a synthetic amino-alkoxyflorenone, has been demonstrated to prolong allografts in rats and dogs. Tilorone, in combination with low dose non-specific immunosuppression, appears to have an additive effect. Tilorone's mechanism of action is unclear at this time but may involve a combination of specific T lymphocyte depletion and interferon induction.
D000818:Animals; D003864:Depression, Chemical; D004285:Dogs; D005449:Fluorenes / Q000627:therapeutic use*; D006084:Graft Rejection / Q000517:prevention & control*; D016027:Heart Transplantation; D007166:Immunosuppressive Agents; D016030:Kidney Transplantation; D008297:Male; D051381:Rats; D016038:Skin Transplantation; D013994:Tilorone / Q000627:therapeutic use*; D014184:Transplantation, Homologous
D005449:Fluorenes; D007166:Immunosuppressive Agents; D013994:Tilorone