Transfer RNA and transfer RNA methylase activity in spleens of patients with Hodgkin's disease and histiocytic lymphoma.
tRNA levels, base composition, and tRNA methylase activities of normal and tumor tissue from the spleens of 24 patients (18 with Hodgkin's disease and 6 with histiocytic lymphoma) were studied. There were no significant differences in major base composition of normal and tumor tissue. Methylated guanosine was increased in tumor tissue of some patients, and tRNA methylase activities were increased in extracts from the tumors.
D006689:Hodgkin Disease / Q000378:metabolism*; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000378:metabolism*; D011687:Purines / Q000032:analysis / Q000652:urine; D011743:Pyrimidines / Q000032:analysis / Q000652:urine; D012343:RNA, Transfer / Q000032:analysis; D013154:Spleen / Q000032:analysis / Q000378:metabolism*; D012359:tRNA Methyltransferases / Q000378:metabolism*
D011687:Purines; D011743:Pyrimidines; D012343:RNA, Transfer; D012359:tRNA Methyltransferases