Induction of the mycelial form of Candida albicans by hydrolysates of peptides from seminal plasma.
Previous work led to the separation from seminal plasma of a peptide fraction which promoted a high rate of germination of blastospores of Candida albicans. It has now been shown that an acid hydrolysate of this material is also highly active. A minimal amino-acid mixture consisting of aspartic acid, lysine, histidine, threonine, proline and beta-alanine gave 90% germination in 4 h with 17 out of 28 strains examined. Glucose and inorganic phosphate were also required. Phosphate was not required for the activity of the original peptide fraction.
D000596:Amino Acids / Q000494:pharmacology; D001769:Blood; D002176:Candida albicans / Q000254:growth & development*; D003470:Culture Media; D005947:Glucose / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology; D010710:Phosphates / Q000494:pharmacology; D012661:Semen; D013045:Species Specificity; D013172:Spores, Fungal
D000596:Amino Acids; D003470:Culture Media; D010455:Peptides; D010710:Phosphates; D005947:Glucose