Experience of nasal application of inactivated influenza vaccine.
The present experiment shows the efficacity of the sesame-oil adjuvant influenza vaccine. The plain inactivated vaccine merely shows a tendency towards effectiveness and only in a field study was a statistically significant effectiveness observed. We had hitherto made such a field experiment in which the plain inactivated influenza vaccine showed much more effective values. It is not clear that in the present experiment such a result was obtained.  The efficacy of intranasal application of inactivated influenza vaccine seemed to be fairly good and appeared quite soon after spraying, although its effect lasted no more than one month.
D000281:Administration, Intranasal; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D002648:Child; D002986:Clinical Trials as Topic; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D009980:Influenza A virus / Q000276:immunology; D007252:Influenza Vaccines / Q000008:administration & dosage* / Q000627:therapeutic use; D007251:Influenza, Human / Q000517:prevention & control; D007279:Injections, Subcutaneous; D009975:Orthomyxoviridae / Q000276:immunology; D010919:Placebos
D000914:Antibodies, Viral; D007252:Influenza Vaccines; D010919:Placebos