title: The effects of inhibitors of nucleic acid and protein synthesis on the replication of Spodoptera frugiperda nuclear polyhedrosis virus in cultured Spodoptera frugiperda cells.
abstract: The effects of inhibitors of nucleic acid and protein synthesis on the replication of Spodoptera frugiperda nuclear polyhedrosis virus have been determined. Two inhibitors of protein synthesis-cycloheximide and puromycin-were irreversible inhibitors of virus multiplication. Three inhibitors of nucleic acid synthesis-actinomycin D, cytosine arabinoside and camptothecin- prevented virus multiplication; only camptothecin was reversible. Rifampicin had no effect on virus multiplication.
mesh_terms: D002166:Camptothecin / Q000494:pharmacology*; D002460:Cell Line; D003513:Cycloheximide / Q000494:pharmacology*; D003561:Cytarabine / Q000494:pharmacology*; D003609:Dactinomycin / Q000494:pharmacology*; D007304:Insect Viruses / Q000187:drug effects* / Q000254:growth & development; D007313:Insecta; D011691:Puromycin / Q000494:pharmacology*; D012293:Rifampin / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D003561:Cytarabine; D003609:Dactinomycin; D011691:Puromycin; D003513:Cycloheximide; D012293:Rifampin; D002166:Camptothecin