A double-blind comparative clinical trial of floctafenine and four other analgesics conducted in general practice.
Three hundred and twelve patients suffering from painful conditions were admitted to a multicentre, double-blind controlled trial, conducted in general practice in which five analgesics--floctafenine (Idarac), paracetamol, aspirin, dihydrocodeine and pentazocine--were compared. Overall ratings of analgesic effect placed floctafenine first in rank order. Floctafenine was statistically significantly superior in effect to pentazocine but not to the other three agents as far as doctor ratings were concerned; and superior to both pentazocine and dihydrocodeine in the opinion of patients. Fewer patients experienced side-effects on floctafenine than on the other four analgesics and this difference between floctafenine and pentazocine, and floctafenine and dihydrocodeine was statistically significant.
D000082:Acetaminophen / Q000009:adverse effects / Q000627:therapeutic use; D000700:Analgesics / Q000009:adverse effects / Q000627:therapeutic use*; D001241:Aspirin / Q000009:adverse effects / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D006853:Hydrocodone / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male; D010146:Pain / Q000188:drug therapy*; D010423:Pentazocine / Q000009:adverse effects / Q000627:therapeutic use; D011804:Quinolines / Q000009:adverse effects / Q000627:therapeutic use*; D062367:ortho-Aminobenzoates / Q000009:adverse effects / Q000627:therapeutic use*
D000700:Analgesics; D011804:Quinolines; D062367:ortho-Aminobenzoates; D000082:Acetaminophen; D006853:Hydrocodone; D001241:Aspirin; D010423:Pentazocine