[Detection of immuno-stimulation in mice by a new low molecular substance (author's transl)].
With Jerne's plaque technique it was possible to verify that a new compound, termed BA 1, features pronounced immuno-stimulating properties. After single-shot i. v. application of 150 mg/kg body weight this immuno-stimulating action can be demonstrated by way of a significant increase of the plaque numbers compared to untreated controls in healthy mice and, in a somewhat diminished form, also in mice bearing Ehrlich ascites carcinoma. Furthermore, it has been shown that the plaque test proves to be suitable as parameter to describe the defense status in tumor-bearing animals as, in the case of Ehrlich carcinomas, there is a distinct negative correlation between plaque numbers and age or mass of the tumor.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002286:Carcinoma, Ehrlich Tumor / Q000276:immunology; D006462:Hemolytic Plaque Technique; D007109:Immunity / Q000187:drug effects*; D007275:Injections, Intravenous; D051379:Mice; D009369:Neoplasms / Q000276:immunology*; D009570:Nitriles / Q000008:administration & dosage; D014508:Urea / Q000008:administration & dosage / Q000031:analogs & derivatives*
D000970:Antineoplastic Agents; D009570:Nitriles; C006646:N-(2-cyanoethylene)urea; D014508:Urea
Nachweis der Immunstimulation bei der Maus durch eine neue Substanz kleiner Molekülmasse