Inhibition by oestradiol of the pituitary response to luteinizing hormone releasing hormone in the dog.
Intravenous injections of synthetic LH-RH stimulated LH secretion in male dogs. Pretreatment with 50 mug oestradiol-17beta, 60 or 165 min but not 15 min before LH-RH, inhibited LH secretion. Injection of 0.1-10 mug oestradiol 165 min before administration of LH-RH, Blocked LH secretion. Basal plasma LH levels before LH-RH administration were lower in dogs given oestradiol than in controls.
D000818:Animals; D003864:Depression, Chemical; D004285:Dogs; D004958:Estradiol / Q000494:pharmacology*; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors*; D008297:Male; D010902:Pituitary Gland / Q000187:drug effects* / Q000378:metabolism
D007987:Gonadotropin-Releasing Hormone; D004958:Estradiol