A comparative study on the local inflammatory and immunosuppressive activities of anti-mouse anti-lymphocyte sera.
Local inflammatory reaction at the site of injection of anti-human antilymphocyte serum is a troublesome side effect. In this paper, a simple experimental model is presented for studying the local reaction caused by antilymphocyte serum. Anti-mouse antilymphocyte sera were injected intracutaneously and the intensity of the consequent oedema was estimated by the extravasation of Evans Blue dye solution given intravenously. It was found: (a) that rabbit anti-mouse anti-spleen sera produce consistently stronger local reactions than either anti-lymph node or anti-thymus sera; (b) that there is as yet no correlation between the intensity of the local reaction and the immunosuppressive (graft-protective) activity of the anti-lymphocyte serum pools tested. The possible implications of these findings are also discussed.
D000818:Animals; D000961:Antilymphocyte Serum / Q000008:administration & dosage; D006084:Graft Rejection; D007165:Immunosuppression Therapy; D007249:Inflammation; D007279:Injections, Subcutaneous; D008198:Lymph Nodes / Q000276:immunology; D051379:Mice; D016038:Skin Transplantation; D013154:Spleen / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology; D014185:Transplantation, Isogeneic
D000961:Antilymphocyte Serum