Suppression of the primary immune response in vivo to sheep red blood cells by B-cell mitogens.
Polyacrylic acid (PAAC), lipopolysaccharide (LPS), dextran sulphate (DS) and purified protein derivative of tubercle bacilli (PPD), compounds mitogenic for B lymphocytes in vitro, suppressed the immune response of mice to SRBC in vivo, when injected 4-2 days before immunization. The same compounds enhanced the immune response when injected half an hour before immunization of the animals with a suboptimal antigen dose. A subsequent injection of PAAC given shortly before immunization, abolished the immunosuppressive effect expected by pretreatment of the animals with either PAAC or LPS. A second injection of LPS abolished the immunosuppressive effect of LPS only. The results indicate that when B lymphocytes react with a mitogen in the absence of a particular antigen, they temporarily lose their capacity to respond to antigen.
D000179:Acrylates / Q000494:pharmacology; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D000921:Antibody-Producing Cells; D003911:Dextrans / Q000494:pharmacology; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D006460:Hemolysin Proteins / Q000032:analysis; D006462:Hemolytic Plaque Technique; D007114:Immunization; D007165:Immunosuppression Therapy; D008070:Lipopolysaccharides / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D008934:Mitogens / Q000494:pharmacology*; D011108:Polymers / Q000494:pharmacology; D013154:Spleen / Q000276:immunology; D013997:Time Factors; D014373:Tuberculin
D000179:Acrylates; D003911:Dextrans; D006460:Hemolysin Proteins; D008070:Lipopolysaccharides; D008934:Mitogens; D011108:Polymers; D014373:Tuberculin