title: Fluid and electrolyte metabolism in the newborn infant.
abstract: This chapter has sought to gather together the background information on systems controlling homoeostasis of salt and water and their clinical derangement. The temptation to adopt an all-embracing approach to the management of these problems is strong but such an approach is difficult to achieve and indeed dangerous. The circumstances of each sick infant are unique and plans for treatment must be individually tailored and flexible, dependent upon clinical and biochemical progress. Future developments in this field are likely to involve further understanding of renal and hormonal control of fluid and electrolyte and it might be expected that as new methods of management emerge they will be accompanied by their own peculiar risks of inducing secondary homoeostatic disturbances. With regard to infant feeding each advance appears to underline the desirability of breast feeding and support current moves toward provision of low solute feeds for those who are artificially fed. Paediatricians should be vocal in their advocation of breast feeding and ensure that the major principles of salt and water handling are understood by all who work with small infants. An extra scoop of powdered milk can be more of a poison than a food.
mesh_terms: D000450:Aldosterone / Q000502:physiology; D000804:Angiotensin II / Q000502:physiology; D001810:Blood Volume; D003919:Diabetes Insipidus / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000378:metabolism* / Q000503:physiopathology / Q000628:therapy; D007668:Kidney / Q000502:physiology / Q000503:physiopathology; D008660:Metabolism; D009318:Natriuresis; D009751:Nutritional Requirements; D009994:Osmolar Concentration; D011188:Potassium / Q000378:metabolism; D011388:Prolactin / Q000502:physiology; D012083:Renin / Q000502:physiology; D012964:Sodium / Q000378:metabolism; D014667:Vasopressins / Q000502:physiology; D014882:Water-Electrolyte Balance
chemical_list: D014667:Vasopressins; D000804:Angiotensin II; D000450:Aldosterone; D011388:Prolactin; D012964:Sodium; D012083:Renin; D011188:Potassium