title: The mode of action of aspirin and similar compounds.
abstract: Aspirin-like drugs inhibit the biosynthesis of prostaglandins in all tissues and species so far studied. The concentrations necessary for this action are achieved after therapeutic dosage. The evidence is reviewed which establishes this biochemical action as the basic mode of therapeutic action of aspirin-like drugs as anti-inflammatory, analgesic, and antipyretic compounds. It may also account for the shared side effects, including the hypersensitivity to aspirin-like drugs shown by some allergic patients.
mesh_terms: D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D001095:Arachidonic Acids / Q000378:metabolism; D001241:Aspirin / Q000494:pharmacology*; D001980:Bronchi / Q000187:drug effects; D003876:Dermatitis, Atopic / Q000276:immunology; D004342:Drug Hypersensitivity / Q000276:immunology; D004487:Edema / Q000209:etiology; D004890:Erythema / Q000209:etiology; D005334:Fever / Q000209:etiology; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology; D007249:Inflammation / Q000188:drug therapy*; D010146:Pain / Q000209:etiology; D011448:Prostaglandin Antagonists; D011453:Prostaglandins / Q000378:metabolism; D011458:Prostaglandins E / Q000494:pharmacology; D011460:Prostaglandins F / Q000494:pharmacology; D012130:Respiratory Hypersensitivity / Q000276:immunology; D014605:Uveitis / Q000276:immunology
chemical_list: D000893:Anti-Inflammatory Agents; D001095:Arachidonic Acids; D011448:Prostaglandin Antagonists; D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; D001241:Aspirin