The regulation of the immune response to T-independent antigens by prostaglandins and B cells.
The effect of inhibitors of prostaglandin synthesis on the in vitro primary immune response to two T-independent antigens has been investigated. The results, with PVP or DNP-Ficoll, suggest that the prostaglandins play an important role in the regulation of the immune response to these antigens. Furthermore, it appears that B cells may be involved in their own regulation by synthesizing and responding to prostaglandins. Although it has been previously established that T cells exert a regulatory influence on the response to PVP and DNP-Ficoll, this is the first demonstration of an apparent B cell regulation of B cell function via the production of a specific hormone.
D000818:Animals; D000941:Antigens; D001402:B-Lymphocytes / Q000276:immunology*; D004136:Dinitrobenzenes / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D005362:Ficoll / Q000276:immunology; D006462:Hemolytic Plaque Technique; D007111:Immunity, Cellular; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008819:Mice, Nude; D011205:Povidone / Q000276:immunology; D011453:Prostaglandins / Q000096:biosynthesis / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000276:immunology*
D000941:Antigens; D004136:Dinitrobenzenes; D011453:Prostaglandins; D005362:Ficoll; D011205:Povidone