Production of experimental toxemia in the pregnant dog.
The aortas of 14 pregnant bitches were treated 1 to 3 weeks before term, producing a stricture that reduced the lumen from an average normal of 7-11 mm to 2.1 mm in diameter. Nine animals developed hypertension, 3 had significant proteinuria, and 1 had fluid retention. Light microscopy revealed moderate or severe glomerular lesions in 9 animals characterized by endotlial cell swelling, mesangial cell proliferation, and focal basement membrane thickening; electron microscopy revealed mesangial enlargement and electron-dense deposits. Immunofluorescence with rabbit anti-dog fibrinogen showed glomerular deposition of fibrinogen or its breakdown products in 11 of 12 cases so studied. Focal necrosis was seen in the liver in 5 cases, and diffuse hemorrhagic infarction of the placenta was present in all animals. None of these changes was found in nonpregnant or in sham-operated controls.
D000818:Animals; D001011:Aorta / Q000502:physiology; D001794:Blood Pressure; D004195:Disease Models, Animal; D004285:Dogs; D005260:Female; D005455:Fluorescent Antibody Technique; D007668:Kidney / Q000473:pathology; D007678:Kidney Glomerulus / Q000473:pathology / Q000648:ultrastructure; D008099:Liver / Q000473:pathology; D010920:Placenta / Q000473:pathology; D011225:Pre-Eclampsia / Q000473:pathology / Q000503:physiopathology; D011247:Pregnancy