Antihypertensive effects, plasma levels and beta-adrenergi blocking activity of racemic and dextrorotatory propranolol in man.
In hypertensive patients, whose blood pressure was decreased by racemic propranolol, the dextrorotatory isomer had no antihypertensive effect. The differences in antihypertensive activity of racemic and dextrorotatory propranolol cannot be explained by different plasma levels. The data indicate that the hypotensive effect of propranolol is due to beta-receptor blockade.
D001794:Blood Pressure; D002986:Clinical Trials as Topic; D006339:Heart Rate; D006801:Humans; D007536:Isomerism; D009904:Optical Rotation; D011433:Propranolol / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000097:blood / Q000494:pharmacology*
D011433:Propranolol