[Double-blind trial: ketoprofen versus phenylbutazone in acute gouty arthritis (author's transl)].
A double-blind study was carried out to compare the effects of ketoprofen and phenylbutazone in acute gouty arthritis. Two groups of patients, each consisting of 23 males, received intramuscular injections of either phenylbutazone (2 X 300 mg daily) or ketoprofen (2 X 50 mg daily) for a period of 7 days. The drug effects were assessed both subjectively and objectively. There was an excellent therapeutic effect in both groups. In general, no statistically-significant differences were detected between the two preparations. However, ketoprofen appears to be slightly better tolerated with respect to the incidence of systemic and local side effects. Thus, the administration of ketoprofen can be recommended in cases of acute gouty arthritis.
D000208:Acute Disease; D000328:Adult; D000368:Aged; D001168:Arthritis / Q000188:drug therapy*; D001577:Benzophenones / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D004361:Drug Tolerance; D005260:Female; D006073:Gout / Q000188:drug therapy*; D006801:Humans; D007273:Injections, Intramuscular; D007660:Ketoprofen / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010653:Phenylbutazone / Q000627:therapeutic use*
D001577:Benzophenones; D007660:Ketoprofen; D010653:Phenylbutazone
Doppelblindstudie: Ketoprofen gegen Phenylbutazon bei akuter Gichtarthritis