Inhibition of insulin release by synthetic rat C-peptide II in isolated rat islets.
The effect of synthetic rat C-peptide on glucose-induced insulin release was studied in isolated islets of rat pancreas. Addition of rat C-peptide II to the medium inhibited glucose-induced insulin release from islets by 30 to 40 percent. Rat C-peptide I, human connecting peptide and bovine, porcine and canine C-peptides had no significant effects on insulin release from islets of rat pancreas.
D000818:Animals; D002096:C-Peptide / Q000494:pharmacology*; D005947:Glucose / Q000494:pharmacology; D006801:Humans; D007328:Insulin / Q000378:metabolism* / Q000494:pharmacology; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D013045:Species Specificity
D002096:C-Peptide; D007328:Insulin; D010455:Peptides; D005947:Glucose