title: Discontinuous synthesis of lac messenger ribonucleic acid in a mutant of Escherichia coli with a new lac promoter.
abstract: A mutant of Escherichia coli with a new promoter for the lac operon exhibits dramatic discontinuities in the synthesis of lac messenger ribonucleic acid after induction. These discontinuities immediately precede similar discontinuities in the synthesis of beta-galactosidase. The discontinuous synthesis of beta-galactosidase persists after addition of rifampin.
mesh_terms: D004790:Enzyme Induction; D004926:Escherichia coli / Q000201:enzymology / Q000378:metabolism*; D005696:Galactosidases / Q000096:biosynthesis; D005947:Glucose / Q000378:metabolism; D007700:Kinetics; D007785:Lactose / Q000378:metabolism*; D009154:Mutation; D009876:Operon; D012329:RNA, Bacterial / Q000096:biosynthesis*; D012333:RNA, Messenger / Q000096:biosynthesis*; D012293:Rifampin / Q000494:pharmacology
chemical_list: D012329:RNA, Bacterial; D012333:RNA, Messenger; D005696:Galactosidases; D005947:Glucose; D007785:Lactose; D012293:Rifampin