title: A shift from phospholipid to triglyceride synthesis when cell division is inhibited by trans-fatty acids.
abstract: The yeast mutant Saccharomyces cerevisiae (KD 46) requires added unsaturated fatty acid for growth.  When cell growth was inhibited by the presence of trans-acids there was a marked inhibition of oleate esterification into phospholipids accompanying continued incorporation into triglycerides. Apparently some control point in phospholipid synthesis associated with the cell cycle occurs after the stage of phosphatidate biosynthesis.
mesh_terms: D002455:Cell Division / Q000187:drug effects*; D005230:Fatty Acids, Nonesterified / Q000378:metabolism / Q000494:pharmacology*; D007700:Kinetics; D010743:Phospholipids / Q000096:biosynthesis*; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000378:metabolism*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013997:Time Factors; D014280:Triglycerides / Q000096:biosynthesis*
chemical_list: D005230:Fatty Acids, Nonesterified; D010743:Phospholipids; D014280:Triglycerides