title: Jejunal lysozyme activity and the Paneth cell in coeliac disease.
abstract: The jejunal mucosa of patients with coeliac disease contains significantly fewer Paneth cells (PCC) per crypt (p less than 0.001) and tissue lysozyme activity (JLA) P less than 0.001) when compared with a group of subjects with normal jejunal mucosa. Neither PCC nor JLA return to normal with complete clinical recovery and otherwise complete histological recovery on a gluten free diet. There is a significant linear correlation between JLA and PCC suggesting that the Paneth cell is the principal source of jejunal lysozyme.
mesh_terms: D000328:Adult; D002446:Celiac Disease / Q000178:diet therapy / Q000201:enzymology* / Q000473:pathology; D004044:Dietary Proteins / Q000008:administration & dosage; D005260:Female; D005983:Glutens / Q000008:administration & dosage; D006801:Humans; D007413:Intestinal Mucosa / Q000201:enzymology / Q000473:pathology; D007583:Jejunum / Q000201:enzymology* / Q000473:pathology; D008297:Male; D009113:Muramidase / Q000378:metabolism*
chemical_list: D004044:Dietary Proteins; D005983:Glutens; D009113:Muramidase