The centineurogenic etiology of the respiratory distress syndrome. Protection afforded by anemia and pulmonary denervation against lung lesions of oxygen toxicity.
For beagles respiring 100 per cent oxygen at ambient pressure, anemia protected against the development of the lung lesions of oxygen toxicity. Similarly, unilateral pulmonary denervation was protective of the affected lung but not of the normally innervated, contralateral lung. This indicates that the lung lesions are triggered by the toxic effect of elevated PO2 at a remote site, most likely the sensitive central nervous system.
D000740:Anemia; D000818:Animals; D002490:Central Nervous System; D003714:Denervation; D004285:Dogs; D006801:Humans; D007231:Infant, Newborn; D008168:Lung / Q000294:innervation*; D016040:Lung Transplantation; D010100:Oxygen / Q000009:adverse effects*; D010313:Partial Pressure; D012127:Respiratory Distress Syndrome, Newborn / Q000209:etiology* / Q000517:prevention & control; D014182:Transplantation, Autologous
D010100:Oxygen