A heterophile system in human renal transplantation. VI. Biologic effect of heterophile (HT-A) and nonheterophile (HL-A) compatibility on allograft survival.
A series of 79 selected renal allografts has been studied to determine the biologic importance of the heterophile (HT-A) locus and the relative effects of HT-A and nonheterophile (HL-A) loci on allograft survival. The results demonstrate that HT-A and HL-A compatibility together yield poor results, whereas HT-A and HL-A incompatibility together yield poor results. HT-A incompatibility with any serologically determined HL-A incompatibilities give a one year allograft survival of 34%, and with two or more HL-A incompatibilities the one year survival rate is only 22%. Compatibility at one locus with incompatibility at the other yields intermediate results. Thus incompatibilities at both loci seem cumulative. The chief difference in the effect of incompatibility of the two loci is that HT-A incompatibility is decisive early, whereas HL-A effects are seen later. The HT-A system appears to be a major determinant of renal allografts success which needs to be taken into account in compatibility testing.
D015478:Antigens, Heterophile; D006084:Graft Rejection / Q000276:immunology*; D006649:Histocompatibility Antigens; D006801:Humans; D016030:Kidney Transplantation; D014184:Transplantation, Homologous
D015478:Antigens, Heterophile; D006649:Histocompatibility Antigens