title: Differential survivals of F1 hybrid allografts in parental recipients.
abstract: Differential survival times of various organ allografts in the rat across the same histocompatiblity barrier were studied by transplanting the kidney, heart, intestine, pancreas, and skin from (BN X Le)F1 hybrid donors to Lewis recipients. Some (one-third) of the kidney grafted rats survived for a prolonged period of time (32-72 days, plus one rat surviving over 9 months), whereas all other organs and skin were promptly rejected between 7 and 21 days. Possible factors responsible for the prolonged kidney survival are discussed; the reason for this was not clear but was not related to the period of operative ischemia or postoperative blood-urea-nitrogen, nor were animals tolerant to donor antigen as evidenced by the popliteal lymph node weight assay and signs of mild rejection on histology of grafted kidneys. A hypothesis of autoenhancing mechanism is presented.
mesh_terms: D000818:Animals; D006084:Graft Rejection; D016027:Heart Transplantation; D006824:Hybridization, Genetic; D007082:Ileum / Q000637:transplantation*; D016030:Kidney Transplantation; D008198:Lymph Nodes / Q000033:anatomy & histology; D008297:Male; D009929:Organ Size; D016035:Pancreas Transplantation; D051381:Rats; D011914:Rats, Inbred BN; D011917:Rats, Inbred Lew; D016038:Skin Transplantation; D014184:Transplantation, Homologous