Cytochrome P-450 and drug metabolism in Trypanosoma cruzi: effects of phenobarbital.
The epimastigotes of Trypanosoma cruzi hydroxylate drugs at substantial rates. The activity, which is of the mixed-function oxidase type, is increased by phenobarbital and is inhibited by CO, SKF 525-A, and metyrapone. The hydroxylation is paralleled by increases in free and membrane-bound ribosomes.
D000632:Aminopyrine / Q000378:metabolism; D000814:Aniline Compounds / Q000378:metabolism; D000818:Animals; D000840:Anisoles / Q000378:metabolism; D002248:Carbon Monoxide / Q000494:pharmacology; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D008797:Metyrapone / Q000494:pharmacology; D008861:Microsomes / Q000201:enzymology; D006899:Mixed Function Oxygenases / Q000037:antagonists & inhibitors / Q000378:metabolism; D010090:Oxidoreductases, O-Demethylating / Q000378:metabolism; D010634:Phenobarbital / Q000494:pharmacology*; D011335:Proadifen / Q000494:pharmacology; D012270:Ribosomes / Q000378:metabolism; D014349:Trypanosoma cruzi / Q000378:metabolism* / Q000648:ultrastructure
D000814:Aniline Compounds; D000840:Anisoles; D000632:Aminopyrine; D002248:Carbon Monoxide; D003577:Cytochrome P-450 Enzyme System; D011335:Proadifen; D006899:Mixed Function Oxygenases; D010090:Oxidoreductases, O-Demethylating; D010634:Phenobarbital; D008797:Metyrapone