title: Clinical trials with intranasally administered WRL 105 strain live influenza vaccine in volunteers.
abstract: The results of clinical trials carried out  with WRL 105 strain live influenza vaccine are reviewed. These studies aim to assess the immunogenicity and reactivity of the strain and its propensity for transmission to unvaccinated contacts. The advantages of one and two dose schedules are discussed.
mesh_terms: D000281:Administration, Intranasal; D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D002986:Clinical Trials as Topic; D005260:Female; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D009980:Influenza A virus / Q000276:immunology; D007252:Influenza Vaccines / Q000008:administration & dosage* / Q000627:therapeutic use; D007251:Influenza, Human / Q000517:prevention & control*; D008297:Male; D014613:Vaccines, Attenuated / Q000008:administration & dosage
chemical_list: D000914:Antibodies, Viral; D007252:Influenza Vaccines; D014613:Vaccines, Attenuated