Relationship between ppGpp levels and rates of protein and RNA synthesis in Escherichia coli.
When amino acid starvation is ended in stringent (relA+) strains of escherichia coli, the rates of RNA and protein synthesis as well as their accumulation return to normal more slowly in spoT- PSTRAIns than in the spoT+ strains. The level of ppGpp accumulated declines more slowly in the spoT- strains than in the spoT+ strains. Thus, there is an inverse relationship between ppGpp levels and the rates of RNA and protein synthesis. The slow resumption of protein synthesis in the spoT- relA+ strains could therefore be explained in terms of the limited synthesis of mRNA species coding for the bulk of cellular proteins.
D001426:Bacterial Proteins / Q000096:biosynthesis*; D004926:Escherichia coli / Q000378:metabolism*; D005838:Genotype; D006150:Guanine Nucleotides / Q000378:metabolism*; D007532:Isoleucine / Q000378:metabolism; D009154:Mutation; D014176:Protein Biosynthesis; D012329:RNA, Bacterial / Q000096:biosynthesis*; D013045:Species Specificity; D014158:Transcription, Genetic
D001426:Bacterial Proteins; D006150:Guanine Nucleotides; D012329:RNA, Bacterial; D007532:Isoleucine