title: Maternal serum metabolites during prolonged starvation in pregnant pigs.
abstract: Pregnancies in pigs were sustained during periods of prolonged starvation in spite of maternal body weight losses exceeding 40 kg. Maternal stores of protein were made available for feto-placental development during starvation of the dam. Concentrations of maternal serum proteins, urea nitrogen, electrolytes, and iron were determined in sequential blood samples of healthy Yorkshire pigs during a prolonged period of 40 days inanition (water only) in either the middle third (days 30-70) or last third (days 70-110). Serum protein levels remained similar to full-diet controls throughout these two periods, whereas serum concentrations of albumin and urea N increased primarily during the last third of gestation in starved dams. Serum Na+ levels declined during prolonged inanition while Ca2+ increased and K+ remained unchanged. It was only near term that Fe2+ levels decreased in those dams starved during a period of 40 days in the last third of pregnancy. These results indicated that maternal serum components were sustained at adequate levels to maintain normal development of conceptuses during prolonged starvation in either the middle third or last third of pregnancy in the pig.
mesh_terms: D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D001806:Blood Urea Nitrogen; D003338:Corpus Luteum / Q000502:physiology; D004573:Electrolytes / Q000097:blood; D005260:Female; D005313:Fetal Death / Q000209:etiology; D005333:Fetus / Q000502:physiology; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism*; D013217:Starvation / Q000503:physiopathology*; D013552:Swine / Q000502:physiology*; D013997:Time Factors
chemical_list: D001798:Blood Proteins; D004573:Electrolytes