title: [Effect of Co-trimoxazole on renal creatinine excretion in man (author's transl)].
abstract: Clinical observations have shown, that administration of Co-trimoxazole (Trimethoprim-Sulfamethoxazole) may result in an elevation of the serum-creatinine level. In 27 subjects the endogenous creatinine- and inulinclearance were measured before and during oral or parenteral application of Co-trimoxazole. The inulinclearance showed no significant differences (p greater than 0,05). But the endogenous creatinine clearance showed a reduction of 18% during the oral and of 13% during the parenteral treatment (p less than or equal to 0,05). These observations indicate a functional inhibition of the tubular creatinine secretion by Co-trimoxazole.
mesh_terms: D000328:Adult; D003404:Creatinine / Q000097:blood / Q000652:urine*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007444:Inulin / Q000652:urine; D008297:Male; D013420:Sulfamethoxazole / Q000008:administration & dosage / Q000494:pharmacology*; D014295:Trimethoprim / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D004338:Drug Combinations; D007444:Inulin; D014295:Trimethoprim; D003404:Creatinine; D013420:Sulfamethoxazole
vernacular_title: Zur Kreatininausscheidung beim Menschen nach Gabe von Co-Trimoxazol.