Anticoagulant-induced necrosis of skin and subcutaneous tissues: report of two cases and review of the English literature.
Two cases of necrosis of skin and subcutaneous tissues in patients taking oral anticoagulants are reported, and the English literature is reviewed. The mechanism of coumarin necrosis remains unknown. Most patients are women and the lesions are most common on the abdomen, buttocks, thighs, and breasts. Simple mastectomy is the usual treatment for a breast lesion. Although some cases have been reported in which the skin lesion has healed despite continued anticoagulant therapy, curtailing its use is recommended. Heparin has not been associated with skin necrosis, however, and may be desirable if continued anticoagulant treatment is necessary.
D000925:Anticoagulants / Q000009:adverse effects*; D001941:Breast Diseases / Q000139:chemically induced / Q000601:surgery; D003374:Coumarins / Q000009:adverse effects; D005260:Female; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008408:Mastectomy; D008875:Middle Aged; D009336:Necrosis; D012871:Skin Diseases / Q000139:chemically induced* / Q000473:pathology; D014859:Warfarin / Q000009:adverse effects
D000925:Anticoagulants; D003374:Coumarins; D014859:Warfarin; D006493:Heparin