title: Alcohol and marijuana effects on ocular tracking.
abstract: Experienced alcohol and marijuana users were instructed to track with their eyes a small spot that moved horizontally back and forth in pendular (sinusoidal) motion across a 7.5-degree field. The frequency of spot oscillation was gradually increased from 0.5 to 3.0 Hz in 40 sec. Eye movement recordings showed the frequency at which smooth tracking and, soon thereafter, saccadic tracking broke down. These smooth and saccadic cutoff frequencies were reduced after administration of alcohol, but not after marijuana or placebo. For low alcohol doses, smooth tracking was impaired and saccadic tracking was unaffected, much like an effect previously reported for barbiturates. Alcohol seems to affect smooth tracking by increasing the central processing time required to generate the appropriate eye movement. It affects saccadic tracking by slightly decreasing saccadic velocity and to a greater extent by increasing latency time, part of which may be devoted to central processing. The site of action of alcohol appears to be central to both the paramedian pontine reticular formation and the flocculus of the cerebellum.
mesh_terms: D000328:Adult; D002188:Cannabis; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000008:administration & dosage / Q000097:blood / Q000633:toxicity*; D005133:Eye Movements / Q000187:drug effects*; D006801:Humans; D008297:Male; D010919:Placebos; D011930:Reaction Time / Q000187:drug effects; D012438:Saccades / Q000187:drug effects
chemical_list: D010919:Placebos; D000431:Ethanol