Reaction of nitrosamines in the Udenfriend system: principal products and biological activity.
Reaction of diethylnitrosamine in the non-enzymatic, ascorbic acid-dependent, hydroxylating system of Udenfriend yielded N-nitroso-2-(ethylamino)-ethanol as the major product extracted into methylene chloride. The major product derived from nitrosopiperidine in the same system was N-nitroso-4-piperidone. These products, however, were mutagenic to Salmonella typhimurium TA 1535 only when activated by a rat liver microsomal preparation.
D000818:Animals; D001711:Biotransformation; D004052:Diethylnitrosamine / Q000378:metabolism* / Q000494:pharmacology; D008099:Liver / Q000378:metabolism; D008861:Microsomes / Q000378:metabolism; D009154:Mutation; D009602:Nitrosamines / Q000378:metabolism*; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects*
D009602:Nitrosamines; D004052:Diethylnitrosamine