[The treatment of locally confined prostatic carcinoma: radiotherapy versus total prostatectomy (author's transl)].
Recent data show that carcinoma of the prostate is not radioresistant. But not all prostatic cancers are radiosensitive. All information available in the literature on histologically proven local destruction of prostatic cancer tissue, all survival data and reported complications after radiation treatment are reviewed and discussed. The results of radical surgical treatment from various authors but mainly from the series of Belt and Schröder are used for comparison. From these data it is evident that total prostatectomy of stage B and C tumors is superior to radiation therapy as far as local eradication of tumor goes. Five- and ten-year actuarial survival rates are about identical for stage B disease but favor total prostatectomy in stage C patients. Sexual impotence, the most important lasting complication of total prostatectomy, is present in 23-47% of patients after radiotherapy. Urinary incontinence is not known after irradiation but reported after surgery. Long term damage of the lower urinary tract, the gastrointestinal system, or the lymphatics was reported in 2-24% of patients after radiotherapy. The indication for radiation treatment in stage D patients is very questionable. Exact surgical staging by iliac and obturator lymphadenectomy is desirable to rule out stage D disease in locally confined tumors. Radiation treatment is indicated in patients who are not willing to undergo surgery, who are unwilling to accept sexual impotence, or who are poor candidates for surgery from other reasons.
D002471:Cell Transformation, Neoplastic / Q000528:radiation effects; D007172:Erectile Dysfunction / Q000209:etiology; D005069:Evaluation Studies as Topic; D006801:Humans; D008197:Lymph Node Excision; D008297:Male; D011468:Prostatectomy / Q000009:adverse effects; D011471:Prostatic Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D011878:Radiotherapy / Q000009:adverse effects / Q000379:methods; D011879:Radiotherapy Dosage; D012002:Rectal Diseases / Q000209:etiology; D014522:Urethral Diseases / Q000209:etiology; D001745:Urinary Bladder Diseases / Q000209:etiology; D014549:Urinary Incontinence / Q000209:etiology
Behandlung des lokal begrenzten Prostata-Carcinoms: Bestrahlung oder totale Prostatektomie