[Penetration of 35S-lipoate into cells of animals subjected to overloading with the lipoate].
Penetration of 35S-lipoate into nucleated and nucleus-free erythrocytes, isolated cells (enterocytes) and accumulating tissue preparations from intestinal mucosa was studied in presence or in absence of other vitamins. Effect on this process of overloading the penetration of 35S-lipoate into rat and pigeon erythrocytes was found to be increased; under these conditions the enterocytes bind less 35S-lipoate than in control animals. Water-soluble vitamins (nicotinate, riboflavine, thiamin and, especially, panthotenate) decreased the rate of 35S-lipoate penetration into the cells. The mixture of the vitamins caused less distinct inhibitory effect, than the panthotenate only.
D000818:Animals; D002467:Cell Nucleus / Q000187:drug effects / Q000378:metabolism*; D010856:Columbidae; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000187:drug effects / Q000378:metabolism*; D009539:Nicotinic Acids / Q000494:pharmacology; D010205:Pantothenic Acid / Q000494:pharmacology; D051381:Rats; D012256:Riboflavin / Q000494:pharmacology; D013831:Thiamine / Q000494:pharmacology; D008063:Thioctic Acid / Q000378:metabolism*
D009539:Nicotinic Acids; D010205:Pantothenic Acid; D008063:Thioctic Acid; D012256:Riboflavin; D013831:Thiamine
O proniknovenii S35-lipoata v kletki zhivotnykh, podvergnutykh peregruzke