title: The effect of lucanthone on the radiation response of intestinal stem cells in Chinese hamsters.
abstract: Crypt microcolony assay was used to determine the effect of lucanthone on the radiation response of intestinal stem cells in Chinese hamsters . The Dq of the crypt microcolony radiation--survival curve was maximally reduced by 205 rads when lucanthone injection preceded irradiation by 10 hours and was reduced by 140 rads when injection followed irradiation by 5 hours. On simultaneous injection and irradiation, Dq was reduced by only 20 rads; when injection and irradiation were separated by approximately 30 hours, Dq returned to the control value. Lucanthone never affected Do. Thus at non-toxic concentrations, lucanthone reversibly modifies cellular ability to accumulate and repair sublethal radiation damage without affecting radiation sensitivity.
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000528:radiation effects*; D006224:Cricetinae; D007274:Injections, Intraperitoneal; D007421:Intestine, Small / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects*; D008154:Lucanthone / Q000008:administration & dosage / Q000494:pharmacology*; D011833:Radiation Injuries, Experimental / Q000473:pathology*; D011836:Radiation Tolerance; D013997:Time Factors
chemical_list: D008154:Lucanthone