Prophylactic antibiotic therapy and heart valve replacement.
Patients undergoing cardiac bypass for heart valve replacement maintained adequate blood concentrations of cloxacillin throughout the duration of bypass, provided their initial blood concentration was in the therapeutic range. Blood levels related to the time between the last preoperative dose of antibiotic and operation. Maximal values were achieved if an intraoperative bolus of drug was given.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000667:Ampicillin / Q000008:administration & dosage / Q000627:therapeutic use*; D002315:Cardiopulmonary Bypass; D002986:Clinical Trials as Topic; D003023:Cloxacillin / Q000008:administration & dosage / Q000627:therapeutic use*; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D004696:Endocarditis / Q000517:prevention & control*; D005260:Female; D006350:Heart Valve Prosthesis; D006801:Humans; D008034:Lincomycin / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control*; D013997:Time Factors
D000667:Ampicillin; D008034:Lincomycin; D003023:Cloxacillin