The incompetent pyloric sphincter. Bile and mucosal ulceration.
The patient with gastric ulcer (GU) has abnormal reflux of bile-containing duodenal contents into the stomach. Antral gastritis is prominently associated with GU and is more extensive with severe reflux and with ulcer chronicity and probably when bile salts are accompanied by other constituents of duodenal fluids. Smoking is significantly associated with GU, and it produces reflux in normal subjects and in patients with duodenal ulcer, which in turn is commonly associated with GU. Reflux has not been shown to precede either the gastritis or the gastric ulcer and probably persists despite ulcer healing. The pyloric spincter in the patient with GU probably contracts subnormally to endogenous or exogenous secretin or CCK. This can be explained by associated hypergastrinemia since antral acidification improves the response. Because the pylorus may be usually open, abnormal reflux may be related as much or more to disturbances of other gastroduodenal functions known to control the movement of chyme through what may be a relatively passive pyloric zone. Speculation from animal models implicates bile reflux in aspirin-induced and shock-related gastric ulceration and assigns to bile a possible explanation, in part at least, for the apparent therapeutic efficacy of a carbenoxalone derivative and an antipepsin agent. Similar speculation warrants a search in the patient with GU for abnormalities of gastroduodenal peristalsis-related electric activity and for impaired release of secretin, possibly from antral cells of production. Possible abnormal purinergic inhibition of the gastric fundus and pylorus also warrants further study.
D000818:Animals; D001646:Bile / Q000502:physiology*; D002766:Cholecystokinin / Q000378:metabolism / Q000494:pharmacology; D004195:Disease Models, Animal; D004386:Duodenum / Q000503:physiopathology; D005753:Gastric Mucosa / Q000473:pathology* / Q000503:physiopathology; D005755:Gastrins / Q000097:blood; D005756:Gastritis / Q000150:complications / Q000209:etiology; D005764:Gastroesophageal Reflux / Q000150:complications; D006801:Humans; D011706:Pyloric Antrum / Q000503:physiopathology; D011708:Pylorus / Q000502:physiology / Q000503:physiopathology*; D012633:Secretin / Q000378:metabolism / Q000494:pharmacology; D013276:Stomach Ulcer / Q000150:complications / Q000209:etiology*
D005755:Gastrins; D012633:Secretin; D002766:Cholecystokinin