The interaction between anthelmintic drugs and histamine in Ascaris suum.
1 Piperazine reduced the histamine content of Ascaris suum, yet it greatly increased the uptake of histamine from the surrounding medium, the neuromuscular structures of the nematode preferentially increasing in amount. 2 Bephenium reduced the histamine content of Ascaris and the uptake of histamine from the surrounding medium. However, the relative amount in the neuromuscular structures increased. 3 The flaccid paralysing action of piperazine may thus involve increased histamine absorption whereas the spastic paralysing action of bephenium may be independent of histamine.
D006631:Amine Oxidase (Copper-Containing) / Q000378:metabolism; D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D001200:Ascaris / Q000201:enzymology / Q000378:metabolism*; D001598:Bephenium Compounds / Q000494:pharmacology; D004347:Drug Interactions; D005260:Female; D006632:Histamine / Q000378:metabolism*; D006640:Histidine Decarboxylase / Q000378:metabolism; D010879:Piperazines / Q000494:pharmacology
D000871:Anthelmintics; D001598:Bephenium Compounds; D010879:Piperazines; D006632:Histamine; D006631:Amine Oxidase (Copper-Containing); D006640:Histidine Decarboxylase