Participation of a nonenzymatic transformation in the biosynthesis of estrogens from androgens.
The biosynthesis of estrogens from androgens proceeds via three enzymatic hydroxylations, of which the first two take place on the C-19 methyl group and convert it to aldehyde. The final and rate-determining hydroxylation occurs at the 2 beta position, and the product rapidly and nonenzymatically collapses to an estrogen.
D000728:Androgens / Q000378:metabolism*; D055598:Chemical Phenomena; D002621:Chemistry; D004967:Estrogens / Q000096:biosynthesis*; D006801:Humans; D006900:Hydroxylation; D008861:Microsomes / Q000378:metabolism; D010920:Placenta / Q000201:enzymology; D013250:Steroid Hydroxylases / Q000378:metabolism
D000728:Androgens; D004967:Estrogens; D013250:Steroid Hydroxylases