Effects of thyrotropin-releasing hormone on the erythrocyte and leucocyte enzyme activities in man.
The effects of thyrotropin-releasing hormone (TRH) on a group of 12 normal euthyroid subjects (8 males, 4 females) were analyzed through the metabolic response of oxidoreduction chains of red cells and leucocytes of venous blood. During the reaction of the pituitary-thyroid glandular system (increase of circulating TSH and T-3) to hypothalamic stimulation, the authors have demonstrated: (1) a significant reduction in erythrocytic GSH rate with no anomaly of in vitro stability; (2) an obvious stimulation of the two dehydrogenases of the leucocyte pentose shunt: G6PD and 6PGD. Regarding red cells, the same enzymes do not undergo any quantitative modification, and no behavioral difference of acid phosphatase is observed. The authors also refer to the biochemical mechanism which is involved for regulation of the oxidoreductive metabolism in the molecular response to hormonal or hrehormonal solicitations.
D000135:Acid Phosphatase / Q000097:blood*; D000328:Adult; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology*; D005260:Female; D005898:Glass; D005954:Glucosephosphate Dehydrogenase / Q000097:blood*; D006801:Humans; D007962:Leukocytes / Q000187:drug effects / Q000201:enzymology* / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D010734:Phosphogluconate Dehydrogenase / Q000097:blood*; D013961:Thyroid Gland / Q000502:physiology; D013972:Thyrotropin / Q000097:blood; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*; D013997:Time Factors
D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin; D010734:Phosphogluconate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D000135:Acid Phosphatase