[Major deficiency in serum lactate dehydrogenase 1 and 2 isoenzymes: a possible pathogenesis for angina pectoris with normal coronarography].
Sometimes angina pectoris with normal coronarography can be explained by several enzymatic disturbances. These are as follow: -- a marked decrease of serum lactate-deshydrogenase 1 and 2 isoenzymes, -- the absence of myocardial lactate-deshydrogenase isoenzymes, --the decreased affinity for substrate lactate of residual lactate-deshydrogenase in serum, -- the increased production of 2,3 diphosphoglycreate.
D000787:Angina Pectoris / Q000097:blood / Q000201:enzymology* / Q000235:genetics; D004163:Diphosphoglyceric Acids / Q000097:blood; D004588:Electrophoresis, Cellulose Acetate; D005260:Female; D006801:Humans; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood / Q000172:deficiency*; D008297:Male; D009206:Myocardium / Q000201:enzymology; D010375:Pedigree
D004163:Diphosphoglyceric Acids; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase
Le déficit majeur en isoenzymes 1 et 2 de la lacticodéshydrogénase; une pathogénie possible de l'angine de poitrine à coronarographie normale