Platelet aggregation and adhesiveness in classical factor X deficiency and in the abnormal factor X (factor X Friuli) coagulation disorder.
Platelet aggregation to common inductors and to Ristocetin, Thrombofax and Ionophore is normal in congenital factor X deficiency and in factor X Friuli coagulation disorders. Washed normal platelets resuspended in the patient's plasma and in adsorbed normal plasma showed a normal aggregation. On the contrary, normal platelets resuspended in normal serum failed to aggregate. These studies indicate that factor X plays no role in normal platelet aggregation.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D001778:Blood Coagulation Disorders / Q000097:blood*; D000001:Calcimycin / Q000494:pharmacology; D003094:Collagen / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D005171:Factor X Deficiency / Q000097:blood*; D006801:Humans; D007020:Hypoprothrombinemias / Q000097:blood*; D010973:Platelet Adhesiveness / Q000187:drug effects; D010974:Platelet Aggregation / Q000187:drug effects; D012310:Ristocetin / Q000494:pharmacology; D013925:Thromboplastin / Q000494:pharmacology
D012310:Ristocetin; D000001:Calcimycin; D000244:Adenosine Diphosphate; D003094:Collagen; D013925:Thromboplastin; D004837:Epinephrine