Inhibition of sickling in erythrocytes by amino acids.
Sickling of erythrocytes was rapidly and quantitatively inhibited at room temperature by 3.8 mM homoserine, asparagine, and glutamine but by no other amino acid.
D000596:Amino Acids / Q000494:pharmacology*; D000755:Anemia, Sickle Cell / Q000097:blood*; D001216:Asparagine / Q000494:pharmacology; D004912:Erythrocytes / Q000187:drug effects* / Q000473:pathology; D005973:Glutamine / Q000494:pharmacology; D006451:Hemoglobin, Sickle / Q000378:metabolism; D006714:Homoserine / Q000494:pharmacology; D006801:Humans
D000596:Amino Acids; D006451:Hemoglobin, Sickle; D005973:Glutamine; D006714:Homoserine; D001216:Asparagine