title: Investigations of pyrazine derivatives. Part IV. Synthesis and tuberculostatic activity of some 6-alkoxypyrazine-2-carboxylic acids.
abstract: By alcoholysis of 2-cyjano-6-chloropyrazine corresponding 6-alkoxypyrazine-2-imidoesters (1,6,11,16) were formed, which were then transformed in esters and amides of 6-alkoxypyrazine-2-carboxylic acids. Some of these compounds show a weak tuberculostatic activity.
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis / Q000494:pharmacology; D002264:Carboxylic Acids / Q000138:chemical synthesis / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D011719:Pyrazines / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D000995:Antitubercular Agents; D002264:Carboxylic Acids; D011719:Pyrazines