title: Defibrination in obstetrics. Modern concepts.
abstract: Coagulation profiles of serum fibrinogen, factors V and VIII and haemoglobin in normal pregnancies during labour, delivery and the early puerperium are presented. These factors were also studied in patients with abruptio placentae, in intra-uterine death, and in patients whose pregnancies were terminated with intra-amniotic saline and prostaglandin F2alpha. An assessment of fibrinolytic activity in these patients was made using qualitative (euglobulin lysis time) and quantitative (FR-antigen) tests. The coagulation findings presented form a basis for the rational management of defibrination in obstetrics.
mesh_terms: D000028:Abortion, Induced; D000037:Abruptio Placentae / Q000097:blood; D004211:Disseminated Intravascular Coagulation / Q000209:etiology*; D005165:Factor V / Q000032:analysis; D005169:Factor VIII / Q000032:analysis; D005260:Female; D005313:Fetal Death / Q000097:blood; D005340:Fibrinogen / Q000032:analysis; D006385:Hemagglutination Inhibition Tests; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D005779:Immunodiffusion; D007122:Immunoelectrophoresis; D007743:Labor, Obstetric; D049590:Postpartum Period; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000209:etiology*; D011460:Prostaglandins F; D012462:Saline Solution, Hypertonic; D013577:Syndrome
chemical_list: D006454:Hemoglobins; D011460:Prostaglandins F; D012462:Saline Solution, Hypertonic; D005165:Factor V; D005169:Factor VIII; D005340:Fibrinogen