[On the mode of action of antirheumatic drugs (author's transl)].
Since the etiology of rheumatoid arthritis presently is mostly unknown, the therapeutical efforts are focussed on attempts to influence the pathogeneic events occurring in this disease. Among the discussed pathogenic mechanisms aberration of immunereactions seem to play an important role. The drugs mainly used for basical treatment of rheumatoid arthritis are cytostatics, D-penicillamine, gold salts and chloroquine. The clinical experiences with these drugs and their mode of action are reviewed.
D000903:Antibiotics, Antineoplastic / Q000009:adverse effects / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D001379:Azathioprine / Q000627:therapeutic use; D002738:Chloroquine / Q000627:therapeutic use*; D006046:Gold / Q000627:therapeutic use*; D012971:Gold Sodium Thiosulfate / Q000627:therapeutic use*; D006801:Humans; D008727:Methotrexate / Q000627:therapeutic use; D008862:Microsomes, Liver / Q000187:drug effects; D010396:Penicillamine / Q000627:therapeutic use*
D000903:Antibiotics, Antineoplastic; D006046:Gold; D002738:Chloroquine; D012971:Gold Sodium Thiosulfate; D010396:Penicillamine; D001379:Azathioprine; D008727:Methotrexate
Zur Wirkungsweise der bei der chronischen Polyarthritis angewandten Basistherapeutika