4-Isothiocyanato-4'-nitrodiphenylamine (C 9333-Go/CGP 4540), an anthelminthic with an unusual spectrum of activity against intestinal nematodes, filariae and schistosomes.
4-isothiocyanato-4'-nitrodiphenylamine was found to possess activity against intestinal nematodes in mice, against schistosomes in various hosts including primates and against two filarial species in the mongolian jird. Upon administration in a single oral dose it is equally effective against S. haematobium, S. mansoni and S. japonicum.
D000814:Aniline Compounds / Q000627:therapeutic use*; D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use; D001717:Birds; D006224:Cricetinae; D004159:Diphenylamine / Q000031:analogs & derivatives / Q000627:therapeutic use*; D004285:Dogs; D005368:Filariasis / Q000188:drug therapy*; D000882:Haplorhini; D017879:Isothiocyanates; D051379:Mice; D009349:Nematode Infections / Q000188:drug therapy*; D009559:Nippostrongylus; D012547:Schistosoma; D012548:Schistosoma haematobium; D012550:Schistosoma mansoni; D012552:Schistosomiasis / Q000188:drug therapy*; D013861:Thiocyanates / Q000627:therapeutic use
D000814:Aniline Compounds; D000871:Anthelmintics; D017879:Isothiocyanates; D013861:Thiocyanates; D004159:Diphenylamine; C012391:amoscanate