Oral vaccination against Porteus mirabilis.
Mice given a single dose of proteus vaccine orally were protected against 1 MLD (minimum lethal dose) of autologous Proteus mirabilis by the fourth day after vaccination. Three doses of oral vaccine induced protection against 1 MLD autologous challenge for 7 days after vaccination and partial protection for a further 8 weeks. Cross-protection against different strains of Pr. mirabilis and against some strains of Pseudomonas aeruginosa, Serratia marcescens and Providencia species was found in mice immunized orally on three consecutive days with a bivalent proteus vaccine.
D000284:Administration, Oral; D000818:Animals; D001428:Bacterial Vaccines / Q000008:administration & dosage*; D003429:Cross Reactions; D008297:Male; D051379:Mice; D011512:Proteus Infections / Q000517:prevention & control*; D011513:Proteus mirabilis / Q000276:immunology*; D011532:Providencia / Q000276:immunology; D011550:Pseudomonas aeruginosa / Q000276:immunology; D012706:Serratia marcescens / Q000276:immunology; D014611:Vaccination
D001428:Bacterial Vaccines