[Studies of the induction of amyloidosis by chondroitin sulfate. 2. Different distribution of amyloid after subcutaneous and intraperitoneal injection of chondroitin sulfate (author's transl)].
Two groups of mice (A/J/Han) were treated with casein for 3 weeks. They then received chondroitin sulfate for 1 week, the one group subcutaneously and the other intraperitoneally. Intraperitoneally, chondroitin sulfate produces a more pronounced amyloidosis than subcutaneously. It also causes a marked amyloidosis of the draining lymph nodes of the abdomen. These alterations probably result from an unspecific amyloidogenic effect of chondroitin sulfate, which becomes stronger as local concentration increases.
D000005:Abdomen; D000686:Amyloidosis / Q000139:chemically induced*; D000818:Animals; D002364:Caseins; D002807:Chondroitin; D007274:Injections, Intraperitoneal; D007279:Injections, Subcutaneous; D008206:Lymphatic Diseases / Q000139:chemically induced; D051379:Mice; D008815:Mice, Inbred Strains; D013997:Time Factors
D002364:Caseins; D002807:Chondroitin
Untersuchungen über die Amyloidinduktion durch Chondroitinsulfat. 2. Unterschiedliche Amyloidverteilung nach subcutaner und intraperitonealer Injektion