The parenteral application of a new metacycline preparation, tri-metacycline.
Tri-metacycline, one of the new tetracycline complexes (tritetracyclines), is prepared by mere dissolution of metacycline hydrochloride in an aqueous solution of the complexing agent.  In vitro and in vivo studies show a high antibiotic activity.  Significantly lower MIC values were found for tri-metacycline than for the parent compound.  Parenteral administration resulted in high sera and tissue values, without signs of accumulation; excretion via the kidneys was proved.
D000818:Animals; D001409:Bacillus cereus / Q000187:drug effects; D002854:Chromatography, Paper; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D008690:Methacycline / Q000008:administration & dosage / Q000032:analysis* / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D009132:Muscles / Q000378:metabolism; D011817:Rabbits; D013154:Spleen / Q000378:metabolism; D013210:Staphylococcus / Q000187:drug effects; D013997:Time Factors
D008690:Methacycline