Vitamin A acid in benign and malignant epithelial tumours of the skin.
Vitamin A acid has a prophylactic and a therapeutic effect on chemically induced benign and malignant epithelial tumours in mice. Vitamin A acid, given orally, leads to a regression of established skin papillomas. Skin carcinomas too are influenced to a certain degree. Furthermore this substance, administered prophylactically, prevents or delays the appearance of skin papillomas and carcinomas. The mechanism of action is discussed.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000287:Administration, Topical; D000818:Animals; D002280:Basal Cell Carcinoma / Q000188:drug therapy*; D004353:Drug Evaluation, Preclinical; D006801:Humans; D007642:Keratosis / Q000188:drug therapy; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009824:Ointments; D010212:Papilloma / Q000139:chemically induced / Q000188:drug therapy* / Q000517:prevention & control; D011832:Radiation Injuries; D012878:Skin Neoplasms / Q000139:chemically induced / Q000188:drug therapy* / Q000517:prevention & control; D014212:Tretinoin / Q000008:administration & dosage / Q000627:therapeutic use*; D014801:Vitamin A / Q000031:analogs & derivatives*
D009824:Ointments; D014801:Vitamin A; D014212:Tretinoin; D015127:9,10-Dimethyl-1,2-benzanthracene