Effect of isoprenaline and nitroglycerine on pressure time indices and coronary graft blood flow in man.
In five patients studied 1 to 3 d after coronary artery surgery isoprenaline and nitroglycerine have been used to alter the systolic (TTI) and diastolic (DPTI) pressure time indices. A close correlation with the predicted relationship between diastolic coronary graft flow and the DPTI/TTI ratio has been demonstrated during isoprenaline-induced tachycardia. Nitroglycerine reduced diastolic coronary graft resistance and increased the DPTI/TTI ratio, effects which are desirable for the relief of angina.
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects*; D001026:Coronary Artery Bypass; D003326:Coronary Circulation / Q000187:drug effects*; D003331:Coronary Vessels / Q000503:physiopathology; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D005996:Nitroglycerin / Q000494:pharmacology*; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects
D005996:Nitroglycerin; D007545:Isoproterenol