[The binding of iron to normal human erythrocyte membranes and its intracellular penetration as a function of different glucides].
In vivo intestinal absorption of iron in rat is greatly enhanced by Lactose and D-Xylose. Both sugars are also able to increase the amount of iron bound to the red cell membrane in the animal. Similar effects have been noted when using human normal red cells. Lactose of D-Xylose are able to convert into an active transport curve the linear diffusion curve which is noted when iron is used without any ligand. It is possible to quantify the effect of both sugars on the flux of iron towards the red cell membrane.
D001665:Binding Sites; D001692:Biological Transport / Q000187:drug effects; D002462:Cell Membrane / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D007501:Iron / Q000097:blood* / Q000378:metabolism; D007785:Lactose / Q000494:pharmacology*; D013268:Stimulation, Chemical; D014994:Xylose / Q000494:pharmacology*
D014994:Xylose; D007501:Iron; D007785:Lactose
Etude de la fixation du fer sur la membrane de l'hématie humaine normale et de sa pénétration intracellulaire en fonction de différents glucides