title: Nucleoside auxotrophy in Drosophila: an autosomal locus yielding mutants supplementable by purine and pyrimidine ribonucleosides.
abstract: Two allelic auxotrophic mutants at a locus close to the bw locus (2-104.5) of Drosophila melanogaster are described. The mutants respond to dietary ribonucleosides (uridine, cytidine, adenosine, guanosine and inosine) but less well to bases or pyrimidine precursors. This phenotype is unique to these mutants. We suggest that the mutants are defective in phosphoribosyl pyrophosphate biosynthesis.
mesh_terms: D000241:Adenosine / Q000378:metabolism; D000483:Alleles; D000818:Animals; D003433:Crosses, Genetic; D003562:Cytidine / Q000378:metabolism; D004331:Drosophila melanogaster / Q000201:enzymology / Q000378:metabolism*; D005260:Female; D006151:Guanosine / Q000378:metabolism; D007288:Inosine / Q000378:metabolism; D008297:Male; D009154:Mutation; D010641:Phenotype; D010754:Phosphoribosyl Pyrophosphate / Q000378:metabolism; D012313:RNA / Q000378:metabolism; D012263:Ribonucleosides / Q000378:metabolism*; D014529:Uridine / Q000378:metabolism
chemical_list: D012263:Ribonucleosides; D006151:Guanosine; D007288:Inosine; D003562:Cytidine; D012313:RNA; D010754:Phosphoribosyl Pyrophosphate; D000241:Adenosine; D014529:Uridine