Myocardial uptake of thallium-201 augmented with bicarbonate: concise communication.
Sodium bicarbonate was used to enhance the myocardial concentration of Tl-201 in rabbits and dogs. Organ distribution studies in rabbits and in vivo imaging in dogs showed a 1.5-2 fold increase in myocardial Tl-201 concentration in bicarbonate-treated animals as compared with matched controls. Image improvement was noted, with threefold enhancement of myocardium-to-liver ratios. The results suggest that a similar improvement may be possible for clinical myocardial imaging.
D000818:Animals; D001639:Bicarbonates; D004285:Dogs; D006331:Heart Diseases / Q000175:diagnosis; D009206:Myocardium; D011817:Rabbits; D011868:Radioisotopes; D011877:Radionuclide Imaging; D012964:Sodium; D013793:Thallium
D001639:Bicarbonates; D011868:Radioisotopes; D012964:Sodium; D013793:Thallium