Synthesis and in vitro cytotoxic activity of new n-diazoacetylglycine derivatives.
The syntheses of various N-diazoacetylglycine derivatives are described. The results of an in vitro screening carried out on KB cells for cytotoxic activity are reported. The most active compounds are DGE, DGiBA and DGHA. A possible relationship between the activity and the liposolubility of these compounds is discussed.
D000970:Antineoplastic Agents; D001391:Azo Compounds / Q000627:therapeutic use*; D002460:Cell Line; D004353:Drug Evaluation, Preclinical; D005998:Glycine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D001391:Azo Compounds; D005998:Glycine