title: Studies on hepatic function in the male langur (presbytis entellus entellus) following the administration of alpha-chlorohydrin.
abstract: 1. ALPHA-Chlorohydrin, an inhibitor of spermatogenesis in langur (Presbytis entellus entellus) has been studied to ascertain whether any disturbance of liver function occurred in long term treatment with this compound. 2. Serum aminotransferase remained within normal limits while oral administration of alpha-chlorohydrin (13 mg/kg) were being taken. In subcutaneous treatment, the serum-aminotransferases were being raised during the period of administration, but returned to normal after cessation of drug administration. 3. The alkaline phosphatase levels were in normal range. 4. alpha-Chlorohydrin administration elevated the liver and plasma cholesterol levels. 5. The compound is a hypoglycaemic agent. A "sweet contraceptive" is an attractive proposition.
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D002728:Chlorohydrins / Q000008:administration & dosage* / Q000494:pharmacology; D002784:Cholesterol / Q000097:blood; D003104:Colobus; D000882:Haplorhini; D007194:India; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008297:Male; D000637:Transaminases / Q000097:blood
chemical_list: D002728:Chlorohydrins; D002784:Cholesterol; D000637:Transaminases; D000469:Alkaline Phosphatase