title: [Successes of experimental oncology and problems of the study of the morphogenesis of tumors].
abstract: The present survey deals with requirements the experimental-oncological models used in morphogenetic investigations should meet. Data on ways of inducing tumours of various organs the most suited for such investigations are presented. The available at present literature comprises data on different variants of morphogenesis of tumours; in a number of cases malignant neoplasms can develop against the background of an unchanged structure without previous alterations. Because of a contradictory character of the literature reports on morphogenesis of tumours, further investigations into the morphodynamics of the process of cancerogenesis are needed; at present, this may be successfully implemented if adequate models of the majority of tumour diseases in man are available. These studies are of importance for better understanding of pathogenesis or tumour growth and for ascertaining the concept of precancer changes.
mesh_terms: D015073:2-Acetylaminofluorene; D015127:9,10-Dimethyl-1,2-benzanthracene; D000348:Aflatoxins; D000818:Animals; D001397:Azoxymethane; D001580:Benzopyrenes; D001932:Brain Neoplasms / Q000139:chemically induced; D002273:Carcinogens; D006224:Cricetinae; D004127:Dimethylhydrazines; D004285:Dogs; D004938:Esophageal Neoplasms / Q000139:chemically induced; D005001:Ethionine; D005038:Ethylnitrosourea; D005260:Female; D006413:Hematopoietic System; D007414:Intestinal Neoplasms / Q000139:chemically induced; D008113:Liver Neoplasms / Q000139:chemically induced; D008175:Lung Neoplasms / Q000139:chemically induced; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced; D008769:Methylnitronitrosoguanidine; D008770:Methylnitrosourea; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009602:Nitrosamines; D009603:Nitroso Compounds; D009604:Nitrosoguanidines; D011230:Precancerous Conditions / Q000139:chemically induced; D051381:Rats; D012878:Skin Neoplasms / Q000139:chemically induced; D013274:Stomach Neoplasms / Q000139:chemically induced; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced; D009762:o-Aminoazotoluene; D004124:p-Dimethylaminoazobenzene
chemical_list: D000348:Aflatoxins; D001580:Benzopyrenes; D002273:Carcinogens; D004127:Dimethylhydrazines; D009602:Nitrosamines; D009603:Nitroso Compounds; D009604:Nitrosoguanidines; D008769:Methylnitronitrosoguanidine; D015127:9,10-Dimethyl-1,2-benzanthracene; D008770:Methylnitrosourea; D015073:2-Acetylaminofluorene; D004124:p-Dimethylaminoazobenzene; D001397:Azoxymethane; D005038:Ethylnitrosourea; D009762:o-Aminoazotoluene; D005001:Ethionine
vernacular_title: Uspekhi éksperimental'noĭ onkologii i problemy izucheniia morfogeneza opukholeĭ