title: [Neurophysiologic mechanisms of arterial hypertension under experimental chronic emotional stress].
abstract: Neurophysiological studies were conducted with subhuman primates (macaca mulatta) in order to obtain an estimate of central nervous effects of socio-emotional stress. This was combined with continuously aggravated conditioning procedures in view of the possible significance of chronic environmental stress escalation for etiology and pathogenesis of an arterial hypertension model. Our conclusions are based on evoked potentials (EP) as integrative characteristics of cerebral information processing. The EPs were recorded by means of electrodes chronically implanted in brain structures of emotional and cardio-vascular relevance. Multivariate mathematico-statistical analyses of average EPs (AEP) provide an objective measure of stress sensibility of the individual, particularly of the effects of acute and chronic environmental stress factors upon the functional organization of the CNS. By means of a quantitative approach to AEP we were able to demonstrate a disjunction between distinct limbic and hypothalamic structures starting under stress conditions of subchronic character. We assume that the constancy of functionally antagonistic hyperactive excitation foci at diencephalic and supradiencephalic levels and their specific interaction with the equally stress related neocortical functional insufficiency constitutes a decisive pathogenetic central mechanism of neurotic behaviour. Long-term changes of amplification of external and internal afferences could be demonstrated on the basis of hypo- and hyperreactive neuroelectric functional patterns. These processes cause cerebro-visceral regulatory diseases as, e. g., a primary arterial hypertension by restriction of neocortical control and the corresponding efferent reactions for re-establishment of the dynamic homeostasis.
mesh_terms: D000818:Animals; D001921:Brain / Q000503:physiopathology*; D004569:Electroencephalography; D004644:Emotions; D005071:Evoked Potentials; D000882:Haplorhini; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D007031:Hypothalamus / Q000503:physiopathology; D008032:Limbic System / Q000503:physiopathology; D008253:Macaca mulatta; D009044:Motor Cortex / Q000503:physiopathology; D009433:Neural Inhibition; D011930:Reaction Time; D012688:Septum Pellucidum / Q000503:physiopathology; D013003:Somatosensory Cortex / Q000503:physiopathology; D013315:Stress, Psychological / Q000502:physiology*; D013788:Thalamus / Q000503:physiopathology; D013997:Time Factors
vernacular_title: Neurophysiologische Mechanismen der arteriellen Hypertonie unter chronisch-experimentellem Emotionalstress