title: [Acute leukemia with megakaryoblasts. Incidence following immunosuppressive treatment of rheumatoid polyarthritis].
abstract: The authors report the case of a man suffering from rheumatoid arthritis treated for almost 5 years with chlorambucil. Death occurred 9 years after the onset of the disease at the age of 55 years with a picture of acute megacaryoblastic leukaemia.
mesh_terms: D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D001772:Blood Cell Count; D001854:Bone Marrow Cells; D002699:Chlorambucil / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D015470:Leukemia, Myeloid, Acute / Q000139:chemically induced; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D013920:Thrombocythemia, Essential / Q000097:blood / Q000139:chemically induced*
chemical_list: D007166:Immunosuppressive Agents; D002699:Chlorambucil
vernacular_title: Leucémie aiguë à mégacaryoblastes. Survenue après traitement immunodépresseur d'une polyarthrite rhumatoïde