Metabolic products of microorganisms 137. Rinamycin, a new inhibitor of RNA synthesis.
A new antibiotic rinamycin was isolated from the culture mycelium of a streptomycete designated as Streptomyces venezuelae TU 1102. The antibiotic was obtained as a honey-coloured powder having the tentative molecular formula C20H55N08. It exhibits a significant inhibition of fungi, yeasts, gram-negative bacteria. The primary site of action of the antibiotic was suggested to be the RNA metabolism of rinamycin-sensitive cells.
D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000302:isolation & purification* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects / Q000378:metabolism; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002854:Chromatography, Paper; D003864:Depression, Chemical; D046911:Macromolecular Substances; D008970:Molecular Weight; D012313:RNA / Q000096:biosynthesis*; D013302:Streptomyces / Q000032:analysis*
D000900:Anti-Bacterial Agents; D046911:Macromolecular Substances; D012313:RNA