[Aging of rat liver lactate dehydrogenase and cell renewal].
We have shown the presence of a "Cross Reacting Material" for Lactate Dehydrogenase in liver of very old rats. Partial hepatectomy, followed by hepatic regeneration increases the specific activity of the enzyme, which becomes equal to that of Lactate Dehydrogenase of rat liver. Consequently, aging seems to be a cellular phenomenon and not a consequence of the accumulation of errors in transcription or translation.
D000375:Aging; D000818:Animals; D005260:Female; D006498:Hepatectomy; D007770:L-Lactate Dehydrogenase / Q000032:analysis*; D008099:Liver / Q000201:enzymology* / Q000254:growth & development; D008115:Liver Regeneration; D008297:Male; D051381:Rats
D007770:L-Lactate Dehydrogenase
Vieillissement de la lactico-déshydrogénase hépatique du Rat et renouvellement cellulaire