Erythropoietin level and thrombocytopoiesis in mice.
After administration of a single 1 IU dose of exogenous erythropoietin to mice or by stimulating endogenous erythropoietin production with androgen, the animals' thrombocytopoiesis, measured with selenomethionine incorporation, decreased. The suppression of endogenous erythropoietin level by hypertransfusion also caused a decrease of thrombocytopoiesis.
D000818:Animals; D001772:Blood Cell Count; D001792:Blood Platelets / Q000187:drug effects*; D001803:Blood Transfusion; D004912:Erythrocytes; D004921:Erythropoietin / Q000097:blood / Q000494:pharmacology*; D006410:Hematopoiesis / Q000187:drug effects*; D008533:Megakaryocytes / Q000187:drug effects; D051379:Mice; D012645:Selenomethionine / Q000097:blood; D013739:Testosterone / Q000494:pharmacology; D013997:Time Factors
D004921:Erythropoietin; D013739:Testosterone; D012645:Selenomethionine