Inhibition of pentobarbital-induced release of growth hormone by thyrotropin releasing hormone.
TRH antagonized the GH releasing effect of pentobarbital anesthesia as well in normal as in thyroidectomized rats, and significantly increased plasma B levels in normal animals. This effect was also observed when TRH was administered into a lateral ventricle of the brain in ug amounts, and was suppressed by the beta-adrenergic receptor blocker propranolol. T3 also antagonized the pentobarbital-induced release of GH; however, plasma B levels were not modified, and the effect on plasma GH levels was not suppressed by propranolol.
D000818:Animals; D001921:Brain / Q000187:drug effects; D003345:Corticosterone / Q000097:blood; D004305:Dose-Response Relationship, Drug; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology; D013006:Growth Hormone / Q000097:blood*; D008263:Macrophage Migration-Inhibitory Factors / Q000494:pharmacology; D008297:Male; D010424:Pentobarbital / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D013961:Thyroid Gland / Q000502:physiology; D013965:Thyroidectomy; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*; D014284:Triiodothyronine / Q000494:pharmacology
D008263:Macrophage Migration-Inhibitory Factors; D014284:Triiodothyronine; D007987:Gonadotropin-Releasing Hormone; D013973:Thyrotropin-Releasing Hormone; D013006:Growth Hormone; D011433:Propranolol; D010424:Pentobarbital; D003345:Corticosterone