title: Why control blood glucose levels?
abstract: The controversy as to the relationship between the degree of control of diabetes and the progression of the complications of the disease has not been solved. However, in this review, various studies suggesting a relationship between the metabolic abnormality and the diabetic complications are examined. The disadvantages of the uncontrolled diabetes mellitus can be divided into two major categories-short-term and long-term. The short-term disadvantages of controlled diabetes mellitus include the following: (1) ketoacidosis and hyperosmolar coma; (2) intracellular dehydration; (3) electrolyte imbalance; (4) decreased phagocytosis; (5) immunologic and lymphocyte activity; (6) impairment of wound healing; and (7) abnormality of lipids. The long-term disadvantages of uncontrolled diabetes melitus include the following: (1) nephropathy; (2) neuropathy; (3) retinopathy; (4) cataract formation; (5) effect on perinatal mortality; (6) complications of vascular disease; and (7) the evaluation of various clinical studies suggesting the relationship of elevated blood glucose levels and complications of diabetes mellitus. It is suggested that until the question of control can absolutely be resolved, the recommendation is that the blood glucose levels should be controlled as close to the normal as possible.
mesh_terms: D000138:Acidosis / Q000209:etiology; D000328:Adult; D000818:Animals; D001786:Blood Glucose; D003681:Dehydration / Q000209:etiology; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000628:therapy; D003925:Diabetic Angiopathies / Q000209:etiology; D003926:Diabetic Coma / Q000209:etiology; D003929:Diabetic Neuropathies / Q000209:etiology; D004285:Dogs; D005227:Fatty Acids / Q000378:metabolism; D005260:Female; D005313:Fetal Death / Q000150:complications; D006527:Hepatolenticular Degeneration / Q000209:etiology; D006801:Humans; D006949:Hyperlipidemias / Q000209:etiology; D007328:Insulin / Q000172:deficiency*; D007651:Keto Acids / Q000378:metabolism; D008134:Long-Term Care; D010587:Phagocytosis / Q000187:drug effects; D010758:Phosphorus / Q000378:metabolism; D011188:Potassium / Q000378:metabolism; D011247:Pregnancy; D051381:Rats; D012964:Sodium / Q000378:metabolism; D013997:Time Factors; D014883:Water-Electrolyte Imbalance / Q000209:etiology; D014945:Wound Healing
chemical_list: D001786:Blood Glucose; D005227:Fatty Acids; D007328:Insulin; D007651:Keto Acids; D010758:Phosphorus; D012964:Sodium; D011188:Potassium