The surface morphology and the cell cycle of mastocytoma target cells: no apparent effect on cell-mediated killing.
Mastocytoma cells (P-185) have been separated by velocity sedimentation into fractions which were highly enriched for cells at discrete stages of the cell cycle. By scanning electron microscopy it was shown that the surface morphology of the majority of cells in each fraction was characteristic of that fraction. No difference could be detected between isolated fractions and unfractionated cells in their ability to be lysed by cytotoxic lymphocytes.
D000818:Animals; D002455:Cell Division; D002460:Cell Line; D002462:Cell Membrane; D002469:Cell Separation; D003601:Cytotoxicity Tests, Immunologic; D008214:Lymphocytes / Q000276:immunology*; D012515:Mast-Cell Sarcoma / Q000276:immunology* / Q000503:physiopathology; D051379:Mice / Q000276:immunology; D008855:Microscopy, Electron, Scanning; D013997:Time Factors