Morphological changes of basophils in immunological reactions--effect of sodium cromoglycate.
The morphological changes in blood basophils, from patients with bronchial asthma, were studied in vitro during immunological reactions, with particular reference to interaction with anti-IgE. Anti-human IgE results in an absolute reduction in basophil numbers in buffy coat preparations as well as basophil cytoplasmic degranulation. An increase in the number of pear-shaped (A-form) basophils is also observed. Sodium cromoglycate impairs all these anti-IgE induced basophil changes, providing further insight into the mechanism of action of this compound in bronchial asthma.
D000818:Animals; D001249:Asthma / Q000188:drug therapy; D001491:Basophils / Q000166:cytology / Q000187:drug effects*; D004205:Cromolyn Sodium / Q000494:pharmacology*; D003594:Cytoplasmic Granules / Q000187:drug effects; D006041:Goats / Q000276:immunology; D006801:Humans; D007106:Immune Sera; D007073:Immunoglobulin E; D007074:Immunoglobulin G; D051381:Rats
D007106:Immune Sera; D007074:Immunoglobulin G; D007073:Immunoglobulin E; D004205:Cromolyn Sodium