title: Two-nucleotide codon change in a hemoglobin polymorphism of the Celebes black ape (Macaca nigra).
abstract: A hemoglobin polymorphism involving variant beta-chains was demonstrated in the Celebes black ape, Macaca nigra. Fingerprinting and amino acid analysis of the tryptic peptides from the two chain types have shown that they differ by a single amino acid substitution, between lysine and aspartic acid, which requires a two-nucleotide change in the corresponding codon. Another substitution in the same codon is found as a species between the black ape and that of other macaques.
mesh_terms: D000596:Amino Acids / Q000032:analysis; D000818:Animals; D001224:Aspartic Acid / Q000032:analysis; D003062:Codon; D014644:Genetic Variation; D000882:Haplorhini; D008239:Lysine / Q000032:analysis; D008251:Macaca / Q000097:blood*; D008253:Macaca mulatta / Q000097:blood; D010446:Peptide Fragments / Q000032:analysis; D011110:Polymorphism, Genetic; D014176:Protein Biosynthesis; D012333:RNA, Messenger; D013045:Species Specificity; D014158:Transcription, Genetic; D014357:Trypsin
chemical_list: D000596:Amino Acids; D003062:Codon; D010446:Peptide Fragments; D012333:RNA, Messenger; D001224:Aspartic Acid; D014357:Trypsin; D008239:Lysine