[The effect of hydroxymethyl derivatives of 7,12-dimethylbenz(a)anthracene on its metabolism and toxic action in tissue culture].
The naturally occurring hydroxymethyl derivatives of the carcinogen 7,12-dimethylbenz(a)anthracene was found to inhibit the metabolic hydroxylation and toxic effect of this carcinogen in mouse embryo fibroblast-like cell culture. The greatest reduction of both effects was obtained when 12-hydroxymethyl-7-methylbenz(a)anthracene was added to the growth medium, less effective were, resp., 7,12-dihydroxymethylbenz(a)-anthracene and 7-hydroxymethyl-12-methylbenz(a)anthracene. The data obtained are discussed in terms of the intracellular regulation of carcinogenic hydrocarbon metabolism.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000031:analogs & derivatives / Q000378:metabolism* / Q000494:pharmacology; D001551:Benz(a)Anthracenes / Q000378:metabolism*; D002478:Cells, Cultured
D001551:Benz(a)Anthracenes; D015127:9,10-Dimethyl-1,2-benzanthracene
Vliianie oksimetil'nykh proizvodnykh 7,12-dimetilbenz(a)antratsena i ego metabolizm i toksicheskoe deĭstvie v kul'ture tkani