title: [Metabolites toxic for penicillin biosynthesis in P. chrysogenum fermentation].
abstract: Substances toxic for biosynthesis of penicillin accumulated in the medium at the end of the process during penicillin fermentation. Accumulation of such substances was associated with the mycelium autolysis. Addition of nutrient substances as soon as they are consumed prevented autolysis of the mycelium and accumulation of the toxic metabolites.
mesh_terms: D000042:Absorption; D003470:Culture Media; D004305:Dose-Response Relationship, Drug; D009172:Mycology / Q000379:methods; D010406:Penicillins / Q000037:antagonists & inhibitors / Q000096:biosynthesis* / Q000494:pharmacology; D010407:Penicillium / Q000378:metabolism*; D010408:Penicillium chrysogenum / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D013997:Time Factors; D014118:Toxins, Biological / Q000494:pharmacology
chemical_list: D003470:Culture Media; D010406:Penicillins; D014118:Toxins, Biological
vernacular_title: Toksichnye dlia biosinteza penitsillina metabolity v protsesse fermentatsii P. chrysogenum