title: Radiation dose distributions and their optimization.
abstract: The current situation in the radiotherapy treatment of carcinoma of the larynx is discussed from a physicist's point of view and in the light of the results of one series of patients. The results suggest that the spatial distribution of dose obtainable with supervoltage irradiation for treatment of T1, to T4 No Mo cases is not far from the ideal, and that it is not difficult to prescribe an optimal distribution.  A significant difference in the rate of local cure was found between those treated to a CRE value greater than 1,750 and those treated to less than 1,750.  Gothenburg results supporting this finding are quoted.  Methods are suggested of optimizing the dose distribution in time by increasing the effect on tumor cells without exceeding an acceptable tolerance to normal tissues.
mesh_terms: D004307:Dose-Response Relationship, Radiation; D006801:Humans; D007822:Laryngeal Neoplasms / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D011882:Radiotherapy, High-Energy