title: Rh-immune globulin after amniocentesis for genetic diagnosis.
abstract: The procedure of amniocentesis during the second trimester of pregnancy for genetic diagnosis creates the potential for Rh sensitization secondary to fetomaternal bleeding. We have advised administration of Rh-immune globulin after such amniocentesis whenever the pregnancy may be Rh-incompatible. Of 56 patients who received Rh-immune globulin there has been only 1 case of Rh sensitization, which occurred in a patient who underwent a second amniocentesis 2 weeks after the first attempt without receiving a second dose of Rh-immune globulin. There have been no developmental problems detected to date which could be ascribed to Rh-immune globulin.
mesh_terms: D000328:Adult; D000649:Amniocentesis; D001787:Blood Group Incompatibility / Q000628:therapy; D005260:Female; D005817:Genetic Counseling; D006801:Humans; D007136:Immunoglobulins / Q000008:administration & dosage; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000628:therapy; D011262:Pregnancy Trimester, Second; D012204:Rh-Hr Blood-Group System
chemical_list: D007136:Immunoglobulins; D012204:Rh-Hr Blood-Group System