Loss of rh antigen activity following the action of phospholipase A2 on red cell stroma.
The degradation of red cell stroma phospholipids by phospholipase A2 is accompanied by a concomitant fall in the activity of the Rh antigens, c, D and e.  The action of phospholipase C on stroma also brings about a fall in D antigen activity.  Anti-D bound to the red cells protects the D antigen from inactivation by phospholipase A2.
D000906:Antibodies; D000936:Antigen-Antibody Complex; D001665:Binding Sites; D002462:Cell Membrane / Q000032:analysis / Q000276:immunology / Q000378:metabolism; D004912:Erythrocytes / Q000648:ultrastructure*; D005227:Fatty Acids / Q000378:metabolism; D007457:Iodine Radioisotopes / Q000378:metabolism; D010713:Phosphatidylcholines; D010740:Phospholipases / Q000302:isolation & purification / Q000378:metabolism*; D010743:Phospholipids / Q000032:analysis; D012204:Rh-Hr Blood-Group System / Q000032:analysis*; D014688:Venoms
D000906:Antibodies; D000936:Antigen-Antibody Complex; D005227:Fatty Acids; D007457:Iodine Radioisotopes; D010713:Phosphatidylcholines; D010743:Phospholipids; D012204:Rh-Hr Blood-Group System; D014688:Venoms; D010740:Phospholipases