title: Phosphatidylkojibiosyl Diglyceride: metabolism and function as an anchor in bacterial cell membrane.
abstract: The recently discovered phosphoglycolipid, phosphatidylkojibiosyl diglyceride (PKD), was first observed as a biosynthetic by-product of glycosyl diglyceride metabolism in Streptococcus faecalis (faecium) ATCC 9790.  Its structure is 1, 2-diacyl-3-O-alpha-Dglucopyranosyl-6'-O-phosphoryl-  [1'', 2''-diacyl-3''-O-sn-glycerol]-alpha-D-glucopyranosyl)-sn-glycerol.  The biosynthesis of phosphatidyl-kojibiosyl diglyceride occurs by a novel transphosphatidylation reaction in which a phosphatidyl glycerol to the primary alcohol function at the 6 position of the internal glucose of kojibiosyl diglyceride.  The reaction is catalyzed by a membrane-derived enzyme.  Phosphatidyl-kojibiosyl diglyceride is bound covalently through a phosphodiester bond to the polyglycerol phosphate moiety of membrane lipoteichoic acid from S. faecalis.  Phosphatidylkojibiosyl diglyceride has four nonpolar long chain fatty acyl groups and appears to have the necessary physico-chemical properties to anchor the long hydrophilic glycerol phosphate polymer of lipoteichoic acid to the hydrophobic enviroment of the membrane of S. faecalis and probably other gram-positive bacteria as well.
mesh_terms: D002462:Cell Membrane / Q000502:physiology*; D004075:Diglycerides / Q000502:physiology; D004187:Disaccharides / Q000502:physiology; D013293:Enterococcus faecalis / Q000502:physiology*; D008954:Models, Biological; D010743:Phospholipids / Q000502:physiology*; D013045:Species Specificity
chemical_list: D004075:Diglycerides; D004187:Disaccharides; D010743:Phospholipids