Experimental observations on the effect of amphepramone on the behavior, locomotion, pentretrazol seizures and electroencephalogram.
Amphepramone, an anorectic agent, has been found to possess stimulant properties on the C.N.S. in animals, producing hypermotility and stereotyped movements which can be antagonized with neuroleptics. The stimulant activity of amphepramone observed in animals can be correlated with the amphetamine like psychosis observed in humans.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004053:Diethylpropion / Q000494:pharmacology*; D004357:Drug Synergism; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D010433:Pentylenetetrazole; D011817:Rabbits; D051381:Rats; D012640:Seizures / Q000139:chemically induced; D013239:Stereotyped Behavior / Q000187:drug effects
D004053:Diethylpropion; D010433:Pentylenetetrazole