Electron microscopic study on zinc in B cells of pancreatic islets of rat under conditions stimulating the excretion of insulin.
The process of insulin release from pancreatic B cells was studied electron miscroscopically using the sulfide silver method with zinc as an indicator. The location of silvered grains was regarded as the same as that of insulin. The results of various investigations stated in this report suggest that the main process of insulin release from B cells be the dissolving process of beta granules.
D000818:Animals; D002747:Chlorpropamide / Q000494:pharmacology; D003594:Cytoplasmic Granules / Q000032:analysis; D005947:Glucose / Q000494:pharmacology; D006651:Histocytochemistry; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000032:analysis / Q000378:metabolism* / Q000648:ultrastructure; D007930:Leucine / Q000494:pharmacology; D008297:Male; D011485:Protein Binding; D051381:Rats; D013440:Sulfides; D014044:Tolbutamide / Q000494:pharmacology; D015032:Zinc / Q000032:analysis* / Q000378:metabolism
D007328:Insulin; D013440:Sulfides; D014044:Tolbutamide; D007930:Leucine; D005947:Glucose; D015032:Zinc; D002747:Chlorpropamide