The in vitro hydroxylation of 4'-chloro-4-biphenylol by a mushroom tyrosinase preparation.
Incubation of 4'-chloro-4-biphenylol with a mushroom tyrosinase preparation gave the catechol, 4'-chloro-3,4-biphenyldiol as the sole in vitro metabolite. This compound was identical with the major rat urinary metabolite of 4'-chloro-4-biphenylol and thus confirms the structure assigned to the metabolite. This result also demonstrates a possible degradation pathway of hydroxylated chlorobiphenyls which are themselves the major metabolic degradation products of polychlorinated biphenyls.
D004156:Catechol Oxidase / Q000378:metabolism*; D002396:Catechols / Q000378:metabolism; D002474:Cell-Free System; D006900:Hydroxylation; D011078:Polychlorinated Biphenyls / Q000378:metabolism*
D002396:Catechols; D011078:Polychlorinated Biphenyls; D004156:Catechol Oxidase