Successful treatment of Pseudomonas meningitis and septicemia in a leukemic neutropenic adult.
Pseudomonas aeruginosa is thought to be one of the main species of bacteria producing infection in leukemic patients, especially in those with neutropenia. Although bacteremia is frequent, hematogenous spread causing secondary meningitis is rarely seen. The mortality rate is extremely high. This is believed to be the first report of a successfully treated secondary meningitis caused by Pseudomonas aeruginosa in an adult leukemic patient with a decreased neutrophil count. The patient was treated with intravenous Carbenicillin and gentamicin, and intrathecal gentamicin. The good clinical response was supported by a prompt return of the CSF to normal and by appropriate CSF antimicrobial concentration and bacteriostatic activity.
D000328:Adult; D002228:Carbenicillin / Q000134:cerebrospinal fluid / Q000627:therapeutic use; D005260:Female; D005839:Gentamicins / Q000134:cerebrospinal fluid / Q000627:therapeutic use; D006801:Humans; D007275:Injections, Intravenous; D007278:Injections, Spinal; D007938:Leukemia / Q000150:complications; D008161:Lumbosacral Region; D008581:Meningitis / Q000188:drug therapy* / Q000209:etiology; D009503:Neutropenia / Q000150:complications; D011552:Pseudomonas Infections / Q000134:cerebrospinal fluid / Q000150:complications / Q000188:drug therapy*; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification / Q000472:pathogenicity; D018805:Sepsis / Q000188:drug therapy* / Q000209:etiology
D005839:Gentamicins; D002228:Carbenicillin