Non-human primate platelets and arterial tissue cannot convert preformed [14C]lanosterol into[14C]cholesterol in vivo.
In contrast with the prevailing view, we report the inability of non-human primate platelets or arterial tissue to complete the biosynthesis of [14C]cholesterol from [14C]mevalonic acid in vitro or in vivo, or from performed [14C]lanosterol in vivo. The latter observation suggests that these tissues lack one or more components of the methyl sterol demethylase system.
D000818:Animals; D001158:Arteries / Q000378:metabolism*; D001792:Blood Platelets / Q000378:metabolism*; D002784:Cholesterol / Q000096:biosynthesis*; D005260:Female; D000882:Haplorhini; D007810:Lanosterol / Q000378:metabolism*; D008253:Macaca mulatta; D008297:Male; D008798:Mevalonic Acid / Q000378:metabolism*; D010215:Papio
D007810:Lanosterol; D002784:Cholesterol; D008798:Mevalonic Acid