The effects of (+)-amphetamine and fenfluramine on feeding in starved and satiated mice.
(+)-Amphetamine and fenfluramine depressed both the food intake during the first 2 h of feeding of mice adapted to feed between 12:00 and 15:00 daily and the food intake of free feeding mice between 24:00 and 02:00 (lighting on, 09:00-21:00) in a dose-dependent manner. Higher doses of each drug were needed to produce a significant depression in the latter case. However, (+)-amphetamine (0.5-2 mg/kg) markedly increased the negligible food intake of free feeding mice between 12:00 and 14:00, an effect which rapidly disappeared at higher doses. Fenfluramine at doses up to 40 mg/kg had no effect on the feeding of these mice. Nevertheless, as caffeine (10-40 mg/kg) also increased feeding, behavioural arousal might be an important factor in this anomalous feeding response, although a specific action by (+)-amphetamine and caffeine on the feeding centres of the satiated mouse cannot be ruled out.
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D001143:Arousal / Q000187:drug effects; D002110:Caffeine / Q000494:pharmacology; D002940:Circadian Rhythm; D004305:Dose-Response Relationship, Drug; D005247:Feeding Behavior / Q000187:drug effects* / Q000502:physiology; D005277:Fenfluramine / Q000494:pharmacology*; D008297:Male; D051379:Mice; D012527:Satiation / Q000187:drug effects*; D013217:Starvation
D005277:Fenfluramine; D002110:Caffeine; D000661:Amphetamine