[Inner-ear of monkeys under the influence of streptomycin-sulfate (author's transl)].
Eight monkeys were treated with 65 X 150 mg/kg Streptomycine-Sulfate per day given intramuscularly. Their vestibular reactions were investigated several times during and after (up to 7 1/2 months) the medication. Using nystagmography, a decrease of excitability could be realized as long as the drug was given. After the stop of the injections the excitability returned, mostly even up to the normal level. The most reliable vestibular reactions were the vestibular threshold, respectively duration and frequency of the postrotatory nystagmus. Additional medicaiton of Ozothin had some influence on the toxicity of Streptomycine towards the auditory system, but no effect at all regarding the vestibular reactions.
D000818:Animals; D003051:Cochlea / Q000502:physiology; D004347:Drug Interactions; D007758:Ear, Inner / Q000187:drug effects*; D004594:Electrophysiology; D005133:Eye Movements / Q000187:drug effects; D000882:Haplorhini; D008253:Macaca mulatta; D012399:Rotation; D013307:Streptomycin / Q000633:toxicity*; D013997:Time Factors; D014425:Turpentine / Q000633:toxicity; D014724:Vestibular Function Tests / Q000379:methods
D014425:Turpentine; D013307:Streptomycin
Das Verhalten der Labyrinthfunktionen des Affen (Macacus rhesus) unter Streptomycin-Belastung