[Determination of creatine phosphokinase-MB in the serum of patients with myocardial infarction by an immunological method (author's transl)].
The immunological method of determining creatine phosphokinase-MB in the serum of patients with myocardial infarction described here is based on the differential measurements of CK-activities before and after a specific immuno-precipitation of the CK-MB type. The minimum activity of the CK-MB-type which it is possible to determine with this method is 4% of the total activity. In patients with clinically confirmed myocardial infarctions 1-15% (mean 7.8%) of the total activity can be calculated as CK-activity of the MB-type on the first/second day(s) after the infarction. In patients with increased total CK-activity and without verified infarction the CK-MB content does not differ significantly from zero. The differences between the two groups are statistically significant. In patients with myocardial reinfarction the CK-MB-activity is higher than that after the first infarction. The immunological method to determine creatine-phosphokinase isoenzyme MB is of differential-diagnostic value in myocardial infarction.
D004796:Clinical Enzyme Tests; D003402:Creatine Kinase / Q000097:blood*; D006801:Humans; D007158:Immunologic Techniques; D007527:Isoenzymes / Q000097:blood*; D009203:Myocardial Infarction / Q000175:diagnosis / Q000201:enzymology*; D012008:Recurrence
D007527:Isoenzymes; D003402:Creatine Kinase
Immunologischer Nachweis von Creatinkinase-MB im Serum beim Myokardinfarkt.