[Bacteriological studies on the therapy of bacillus pyocyaneus infections].
The effect of combined antibiotics was studied in 25 strains of Pseudomonas aeruginosa by serial diluting tests. A synergistic effect was stated in 15 strains with oxacillin plus ampicillin, and in 7 strains with carbenicillin plus ampicillin. In these examinations, the quantities of antibiotics needed each time were within the highest admissible level of therapuetic concentrations. A constant rate of the optimum single concentrations could not be observed. On principle, the inhibitory tobramycin concentrations (0.06 - 1 gamma/ml) were lower than the corresponding concentrations of gentamycin (0.25 - 2gamma/ml); tobramycin was more effective than gentamycin also in 6 strains resistant to carbenicillin, tobramycin only had a synergistic effect - in five of these six strains - when very high ampicillin concentrations (i.e. 250-500 gamma/ml) were used.
D000667:Ampicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002228:Carbenicillin / Q000494:pharmacology; D002512:Cephalothin / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004347:Drug Interactions; D005839:Gentamicins / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010068:Oxacillin / Q000494:pharmacology; D010403:Penicillin Resistance; D011552:Pseudomonas Infections / Q000188:drug therapy; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D014031:Tobramycin / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D005839:Gentamicins; D000667:Ampicillin; D002228:Carbenicillin; D002512:Cephalothin; D010068:Oxacillin; D014031:Tobramycin
Bakteriologische Untersuchungen zur Therapie von Pyocyaneusinfektionen