[In vivo and in vitro effect of hyperbaric oxygen on lactate dehydrogenase activity of serum and organs of the mouse].
Lactate dehydrogenase activity in Mouse liver, kidney and lung was decreased after exposure to hyperbaric oxygen (1,8 atm) in vivo and in vitro. Oxygen inhibitory effect could occur through the oxidation of LDH essential free sulfhydryl groups. Serum LDH activity was diminished in vitro, while it was strongly increased in vivo. This enhancement probably resulted from the release in serum of cellular enzymes proceeding from oxygen injured tissues. Oxygen might inhibit both H and M LDH sub-units, since isozyme pattern was different in each organ.
D000818:Animals; D005260:Female; D006931:Hyperbaric Oxygenation; D066298:In Vitro Techniques; D007668:Kidney / Q000201:enzymology; D007770:L-Lactate Dehydrogenase / Q000037:antagonists & inhibitors* / Q000097:blood; D008099:Liver / Q000201:enzymology; D008168:Lung / Q000201:enzymology; D051379:Mice; D010100:Oxygen / Q000494:pharmacology*
D007770:L-Lactate Dehydrogenase; D010100:Oxygen
Effet de l'oxygène hyperbare sur l'activité des lactate déshydrogénases du sérum sanguin et d'organes de la Souris, in vivo et in vitro