The photically evoked afterdischarge: a model for the study of drugs useful in the treatment of petit mal epilepsy.
Lightly restrained albino rats were administered dipropylacetic acid, trimethadione, diphenylhydantoin, saline, and a pentylenetetrazol challenge. The results were attributed to the locus of action of the anticonvulsants and strongly support the usefulness of the photically evoked after discharge as a model for the evaluation of thalamically active drugs, with particular reference to those useful in the control of petit mal epilepsy.
D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004832:Epilepsy, Absence / Q000188:drug therapy* / Q000503:physiopathology; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D010433:Pentylenetetrazole / Q000008:administration & dosage / Q000627:therapeutic use; D010672:Phenytoin / Q000008:administration & dosage / Q000627:therapeutic use; D051381:Rats; D012965:Sodium Chloride / Q000008:administration & dosage; D014293:Trimethadione / Q000008:administration & dosage / Q000627:therapeutic use; D014635:Valproic Acid / Q000008:administration & dosage / Q000627:therapeutic use
D000927:Anticonvulsants; D012965:Sodium Chloride; D014635:Valproic Acid; D010672:Phenytoin; D014293:Trimethadione; D010433:Pentylenetetrazole