Influence of endogenous pyrogen on the cerebral prostaglandin-synthetase system.
The biotransformation of arachidonic acid to prostaglandins in vitro is specifically augmented by endogenous pyrogen to a degree depending on the concentration applied, providing that the microsomal fraction of the cerebral cortex is used as prostaglandin-synthetase system. This effect is inhibited by non-steroidal anti-inflammatory agents. These findings are compatible with the hypothesis that prostaglandins might act as mediators of the febrile reaction induced by endogenous pyrogen.
D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D004008:Diclofenac / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D008861:Microsomes / Q000187:drug effects / Q000378:metabolism; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D011453:Prostaglandins / Q000096:biosynthesis*; D011749:Pyrogens / Q000494:pharmacology*; D011817:Rabbits; D012669:Seminal Vesicles / Q000187:drug effects / Q000378:metabolism
D001095:Arachidonic Acids; D011453:Prostaglandins; D011749:Pyrogens; D004008:Diclofenac; D011451:Prostaglandin-Endoperoxide Synthases