title: Variability of three-dimensional structure in immunoglobulins.
abstract: A comparison of various variable immunoglobulin domains demonstrates that structural variability parallels the observed frequency of amino-acid substitutions. The similarity of the structural frameworks is in good agreement with the evolutionary relationships of the chains as derived from sequence analysis.
mesh_terms: D000595:Amino Acid Sequence; D005075:Biological Evolution; D007143:Immunoglobulin Heavy Chains; D007145:Immunoglobulin kappa-Chains; D007136:Immunoglobulins; D011487:Protein Conformation
chemical_list: D007143:Immunoglobulin Heavy Chains; D007145:Immunoglobulin kappa-Chains; D007136:Immunoglobulins