title: Radiation therapy in the management of carcinoma of the external auditory canal, middle ear, or mastoid.
abstract: Twenty-three patients with squamous-cell carcinoma of the external auditory canal, middle ear, or mastoid were treated with combined surgery and irradiation, giving a 5-year NED rate of 48% (11/23). Except in extremely early lesions without bone involvement, treatment by radiation therapy alone was rarely successful and is not recommended. The most serious complication was osteoradionecrosis of the temporal bone; this occurred in 5 patients, all of whom received more than 2,100 rets due to faulty radiotherapeutic technique.
mesh_terms: D001900:Boston; D001922:Brain Abscess / Q000209:etiology; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery; D003037:Cobalt Radioisotopes; D004428:Ear Neoplasms / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery; D004431:Ear, External / Q000601:surgery; D004432:Ear, Middle / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008416:Mastoid / Q000601:surgery; D008875:Middle Aged; D010025:Osteoradionecrosis / Q000209:etiology; D011867:Radioisotope Teletherapy / Q000009:adverse effects; D011879:Radiotherapy Dosage; D011882:Radiotherapy, High-Energy / Q000009:adverse effects; D012888:Skull Neoplasms / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery
chemical_list: D003037:Cobalt Radioisotopes