Dissociation between factor VIII (activity and antigen) and ristocetin-induced platelet aggregation in von Willebrand's disease.
Previously we showed that von Willebrand patients could be separated into 2 groups on the basis of ristocetin-induced platelet aggregation and factor VII (antigen and activity). Ristocetin-induced platelet aggregation and factor VIII exhibited a positive correlation. This paper deals with 5 out of 31 examined von Willebrand patients in which ristocetin-induced platelet aggregation was not in correlation either with factor VIII activity or antigen. The importance of these findings is discussed.
D000941:Antigens / Q000032:analysis; D005169:Factor VIII / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D010973:Platelet Adhesiveness / Q000187:drug effects*; D010974:Platelet Aggregation / Q000187:drug effects*; D012310:Ristocetin / Q000494:pharmacology*; D013268:Stimulation, Chemical; D014842:von Willebrand Diseases / Q000097:blood* / Q000276:immunology
D000941:Antigens; D012310:Ristocetin; D005169:Factor VIII