Genetic analysis of mitomycin C-induced interchange in Drosophila melanogaster females.
A genetic analysis of an array of mitomycin-induced rearrangements in immature Drosophila oocytes is reported. Induced aberrations were recovered representing detachments of the compound-X chromosome, Y chromosome fragments, X chromosome loss and mosaicism. The spectrum of rearrangements induced by mitomycin C was very similar to that induced by X-ray treatment of immature oocytes. This work suggests that mitomycin C has two models of action. The drug is radiomimetic for it induces the types of aberrations recovered after X-irradiation. Mitomycin C also seems to have a delayed effect which is reflected in the relatively high recovery of mosaics.
D000818:Animals; D002869:Chromosome Aberrations; D004331:Drosophila melanogaster / Q000187:drug effects* / Q000528:radiation effects; D005260:Female; D005298:Fertility; D005816:Genetic Complementation Test; D008297:Male; D008937:Mitomycins / Q000494:pharmacology*; D009030:Mosaicism; D009153:Mutagens / Q000494:pharmacology; D009865:Oocytes / Q000187:drug effects / Q000648:ultrastructure; D011831:Radiation Genetics; D012730:Sex Chromosomes / Q000187:drug effects; D014965:X-Rays
D008937:Mitomycins; D009153:Mutagens