[Interferonogenic and antiviral activity of the tobacco mosaic virus, tilorone and sodium nucleinate].
Production of endogenic interferon in animals in responce to administration of tobaco mozaic virus, tilorone and sodium nucleinate was shown. Dependence of interferon production on the type of the inductor and the route of its administration was studied. Absolute innocuiuty of the tobaco mozaic virus for monkeys (macaco-resus) and mice, as well as the absence of any side effects in humans treated with it perorally was shown. The tobaco mozaic virus, tilorone and sodium nucleinate used perorally in treatment of experimental infections of mice caused by the viruses of East and West encephalomyelitis, influenza and tick encephalitis had a pronounced protective effect.
D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001717:Birds; D002478:Cells, Cultured; D003601:Cytotoxicity Tests, Immunologic; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004660:Encephalitis / Q000188:drug therapy; D004663:Encephalitis Virus, Eastern Equine / Q000472:pathogenicity; D004667:Encephalitis Virus, Western Equine / Q000472:pathogenicity; D004675:Encephalitis, Tick-Borne / Q000188:drug therapy; D005449:Fluorenes / Q000494:pharmacology*; D000882:Haplorhini; D006801:Humans; D007251:Influenza, Human / Q000188:drug therapy; D007369:Interferon Inducers / Q000008:administration & dosage / Q000494:pharmacology*; D007372:Interferons / Q000032:analysis; D008251:Macaca; D051379:Mice; D009521:Newcastle Disease / Q000188:drug therapy; D009696:Nucleic Acids / Q000008:administration & dosage / Q000494:pharmacology*; D013994:Tilorone / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D013997:Time Factors; D014027:Tobacco Mosaic Virus / Q000472:pathogenicity*
D000998:Antiviral Agents; D005449:Fluorenes; D007369:Interferon Inducers; D009696:Nucleic Acids; D007372:Interferons; D013994:Tilorone
Interferonogennaia i protivovirusnaia aktivnost' virusa tabachnoĭ mozaiki, tilorona i nukleinata natriia