[Studies on new sulfonylurea derivatives and their metabolites in isolated Langerhans's islets of the rat pancreas (author's transl].
Sulfonylureas which are chemically related to glibenclamide, and glibornuride were tested in the system of isolated islets of Langerhans. Glibenclamide as well as glibenclamide analogues stimulated secretion of insulin within the first 30 min after addition to the medium. Stimulation of insulin secretion by glibornuride occurred from 60 to 90 min after addition of the agent. The results are discussed on the basis of physicochemical properties of the substances.
D000818:Animals; D005905:Glyburide / Q000494:pharmacology; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051381:Rats; D013268:Stimulation, Chemical; D013453:Sulfonylurea Compounds / Q000494:pharmacology*; D013997:Time Factors; D014044:Tolbutamide / Q000494:pharmacology
D007328:Insulin; D013453:Sulfonylurea Compounds; D014044:Tolbutamide; D005905:Glyburide
Untersuchung neuer Sulfonylharnstoffderivate und ihrer Metaboliten an isolierten Langerhansschen Inseln der Ratte