[Metabolism of pregnenolone 16-3H and progesterone 4-14C by 18 day fetal mouse gonads in organotypic culture. Effect of the gonadotropic hormone LH].
Fetal mice testes convert pregnenolone-16-3H and progesterone-4-14C to testosterone in organ culture. The 3H/14C ratio in progesterone and testosterone fractions isolated from culture media suggests the importance of the delta5-3 beta hydroxysteroid pathway in our experimental conditions. LH decreases radioactive testosterone production and increases the activity of the kelta4-3-ketosteroid pathway.
D000818:Animals; D003864:Depression, Chemical; D007986:Luteinizing Hormone / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009924:Organ Culture Techniques; D011284:Pregnenolone / Q000378:metabolism*; D011374:Progesterone / Q000378:metabolism*; D013737:Testis / Q000196:embryology* / Q000378:metabolism; D013739:Testosterone / Q000096:biosynthesis*
D013739:Testosterone; D011374:Progesterone; D011284:Pregnenolone; D007986:Luteinizing Hormone
Métabolisme de la prégnènolone 16-3H et de la progestérone 4-14C par les gonades foetales de souris de 18 jours en culture organotypique. Influence de l'hormone gonadotrope LH