title: Karyotype evolution in cell lines of Drosophila melanogaster.
abstract: The chromosomal changes occurred in two independent cell lines (GM2 and GM3) of Drosophila melanogaster maintained in medium supplemented with serum and in serum-free medium were compared. In both culture conditions and in both lines a chromosomal evolution was revealed. Structural and numerical variations were analysed. The breaks giving rise to rearrangements were at heterochromatic level. Moreover, a tetraploidisation followed by loss of chromosomes or of portions of chromosomes recalls an analogous cycle observed in human cells.
mesh_terms: D000818:Animals; D002460:Cell Line; D002869:Chromosome Aberrations; D002875:Chromosomes; D003470:Culture Media; D004331:Drosophila melanogaster; D014644:Genetic Variation; D006570:Heterochromatin; D011123:Polyploidy
chemical_list: D003470:Culture Media; D006570:Heterochromatin