[In vitro study of the cytotoxic activity of sipunculid leukocytes towards allogeneic and xenogenic erythrocytes].
A cell mediated cytotoxic reaction analogous to that known in Vertebrates is induced in vitro by leukocytes of sipunculid worms (coelomata invertebrates). Xenogenic or allogenic erythrocytes are employed as target cells. A cytotoxic effect always occurs when killer leukocytes react against xenogenic cells. A cytotoxic activity against allogenic erythrocytes occurs in all cases when donors of leukocytes and donors of erythrocytes arise from stations far apart (Roscoff and Arcachon). Between stations near each other (4 miles apart) a cytotoxic effect is noticed only in one case out of three. No reaction is noticed between Sipunculus nudus from the same station.
D000818:Animals; D003601:Cytotoxicity Tests, Immunologic; D004912:Erythrocytes / Q000276:immunology; D007448:Invertebrates / Q000276:immunology*; D007962:Leukocytes / Q000276:immunology*; D013045:Species Specificity
Etude in vitro de l'activité cytotoxique des leucocytes de siponcles à l'encontre d'érythrocytes allogéniques et xénogéniques