title: [Cooperative binding of tolbutamide by isolated rat Islets of Langerhans].
abstract: Rat islets of Langerhans isolated with collagenase bind tolbutamide, an antidiabetic sulfonylurea. Binding shows a cooperative relationship in the range of concentrations of tolbutamide (less than 10(-4) M) which are known to elicit a dose-related stimulation of insulin secretion.
mesh_terms: D000818:Animals; D001665:Binding Sites; D066298:In Vitro Techniques; D007515:Islets of Langerhans / Q000378:metabolism*; D007700:Kinetics; D051381:Rats; D014044:Tolbutamide / Q000378:metabolism*
chemical_list: D014044:Tolbutamide
vernacular_title: Liage coopératif du tolbutamide par les ilots de Langerhans isolés de rat