title: Triiodothyronine withdrawal-a possible test for hypothalamic-pituitary-throid adequacy.
abstract: The aim of this study was to develop a test which could be used as a complement to the assay of serum TSH and the TRH test in the evaluation of hypothalamic-pituitary-thyroid adequacy. When T3, 75mug per day, was given to healthy subjects for 7 days (days 1-7), a significant rebound of serum TSH over the basal value was found on at least two of days 15-17 in nine of ten cases, provided potassium iodide, 10 mg per day, was also given on days 6-16. A much more pronounced rebound of TSH was  obtained when thyroid hormone release was more rigorously blocked with the following medication: 125 mug T3 on days 1-7, 500 mg KI on days 1-16, and 400 mg of a slowly resorbed lithium carbonate preparation on days 1-16. In the latter case TSH rose from an average basal value of 0.96 muU/ml to a mean of 3.41 muU/ml on day 17 in 10 healthy subjects. In a subsequent experiment a similar TSH rebound was obtained with with 125 mug T3 (days 1-7) and 500 mg KI (days 1-16) only. The mechanism whereby the TSH rebound is brought about, remains to be established. One possibility is a transhypothalamic action. In this case the procedure may prove useful as a clinical test for the detection of slight degrees of hypothalamic insufficiency which cannot be diagnosed with certainty by the TRH test. The present experiments provide indirect evidence for a suppressive action of comparatively small doses (10 mg per day) of KI on thyroid hormone release in healthy subjects.
mesh_terms: D006801:Humans; D007031:Hypothalamus / Q000502:physiology*; D010902:Pituitary Gland / Q000502:physiology*; D011863:Radioimmunoassay / Q000379:methods; D013961:Thyroid Gland / Q000502:physiology*; D013972:Thyrotropin / Q000097:blood*; D013973:Thyrotropin-Releasing Hormone / Q000097:blood*; D013974:Thyroxine / Q000097:blood*; D013997:Time Factors; D014284:Triiodothyronine / Q000494:pharmacology
chemical_list: D014284:Triiodothyronine; D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin; D013974:Thyroxine