The protective effect of inhaled BRL 10833 on allergen induced bronchospasm.
BRL 10833, a nitroindanedione, with similar inhibitory activities to DSCG on the immediate type IgE mediated hypersensitivity in the rat, has been shown, when inhaled in a dose of 40 mg, to protect against allergen induced bronchospasm. A significant protective effect of BRL 10833 on the immediate bronchial reaction was seen in five out of ten patients. A single inhalation of 40 mg BRL 10833 seems also to have some protective effect on the late bronchial reaction, following an immediate reaction.
D000293:Adolescent; D000328:Adult; D000336:Aerosols; D000403:Airway Resistance; D000485:Allergens; D001249:Asthma / Q000188:drug therapy; D001986:Bronchial Spasm / Q000517:prevention & control*; D004205:Cromolyn Sodium / Q000627:therapeutic use; D005541:Forced Expiratory Volume; D006801:Humans; D007189:Indans / Q000627:therapeutic use*; D007192:Indenes / Q000627:therapeutic use*; D008297:Male; D012130:Respiratory Hypersensitivity / Q000188:drug therapy*
D000336:Aerosols; D000485:Allergens; D007189:Indans; D007192:Indenes; C012136:nivimedone; D004205:Cromolyn Sodium