[Studies on biological characterization of mammary tumours of the sprague-dawley-rat in the syngeneic tumour-host system. I. Spontaneous primary mammary tumours and tumours induced by oral and intravenous application of DMBA (author's transl)].
Spontaneous and DMBA-induced mammary tumours of a Sprague-Dawley inbred line reared in Berlin-Buch are described. The incidence of spontaneous tumours was 14.3%, of chemically induced tumours 43.6% of all the animals tested. 5 different schedules of application proved superior to the oral route with regard to dose, mortality and tumour incidence. 87.2% of the carcinomas and 12.8% of benign tumours following DMBA treatment developed in the region of the mammary glands.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000008:administration & dosage / Q000009:adverse effects*; D000230:Adenocarcinoma / Q000139:chemically induced; D000232:Adenofibroma / Q000139:chemically induced; D000284:Administration, Oral; D000818:Animals; D001551:Benz(a)Anthracenes / Q000009:adverse effects*; D005260:Female; D007275:Injections, Intravenous; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced*; D051381:Rats; D011919:Rats, Inbred Strains
D001551:Benz(a)Anthracenes; D015127:9,10-Dimethyl-1,2-benzanthracene
Untersuchungen zur biologischen Charakterisierung von Mamma-tumoren der Sprague-Dawley-Ratte im syngenen Tumor-Wirt-System. I. Spontane sowie durch orale und intravenöse Applikation von DMBA erzeugte primäre Mammatumoren