immunoperturbation in paraproteinemia.
The immunoperturbations in paraproteinemias are due predominantly to a disturbance of the B-cell system. The immunologic deficiency is characterized clinically by an increased susceptibility to infections and serologically by a reduction of the nonmyeloma immunoglobulins. In advances cases the capacity to produce specific antibodies is impaired. This may be attributed to a low rate of synthesis or an increased catabolism of normal immunoglobulins.
D001402:B-Lymphocytes / Q000276:immunology; D001796:Blood Protein Disorders / Q000276:immunology*; D001853:Bone Marrow / Q000378:metabolism; D001854:Bone Marrow Cells; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007410:Intestinal Diseases / Q000209:etiology; D008875:Middle Aged; D009101:Multiple Myeloma / Q000276:immunology; D009194:Myeloma Proteins / Q000096:biosynthesis; D012141:Respiratory Tract Infections / Q000209:etiology; D018805:Sepsis / Q000209:etiology; D008258:Waldenstrom Macroglobulinemia / Q000150:complications
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D009194:Myeloma Proteins