Mutagenicity of carcinogenic azo dyes and their derivatives.
The mutagenicity of N,N-dimethyl-4-aminoazobenzene and N-methyl-4-aminoazobenzene and their derivatives was shown on Salmonella typhimurium TA100 and TA98. S-9 Mix, obtained from rat liver after injection of polychlorinated biphenyl, was abligatory for their mutagenic action. N-Acetoxy-N-methyl-4-aminoazobenzene and N-benzoyloxy-N-methyl-4-aminoazobenzene and their 4'-methoxycarbonyl derivatives were also mutagenic on TA100 and TA98 and did not require metabolic activation by S-9 Mix. It is suggested that the carcinogenic effects of azo dyes may involve modification of DNA.
D000818:Animals; D001391:Azo Compounds / Q000378:metabolism / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D008862:Microsomes, Liver / Q000378:metabolism; D009153:Mutagens; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects; D009762:o-Aminoazotoluene / Q000494:pharmacology; D010128:p-Aminoazobenzene / Q000031:analogs & derivatives / Q000494:pharmacology; D004124:p-Dimethylaminoazobenzene / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology*
D001391:Azo Compounds; D009153:Mutagens; D010128:p-Aminoazobenzene; D004124:p-Dimethylaminoazobenzene; D009762:o-Aminoazotoluene