title: [Metabolism of pramiverine (author's transl)].
abstract: The metabolite patterns of 4,4-diphenyl-N-isopropyl-cyclohexylamine-hydrochloride (pramiverine, Sistalgin) in urine, feces, bile and serum of Wistar rats, beagle dogs, rhesus monkey and man were analyzed with radio thin-layer chromatographic techniques. The structures of six pramiverine metabolites were elucidated. Pramiverine is eliminated unchanged in only minute amounts via the renal, the biliary and the fecal route. Consequently an almost quantitative absorption and metabolism takes place. Metabolite patterns in serum and urine differ considerably indicating that some of the metabolites are excreted preferentially by the kidney while others are reabsorbed to various degrees. The identified metabolites are products of dealkylation, deamination and hydroxylation reactions.
mesh_terms: D000818:Animals; D001559:Benzhydryl Compounds / Q000378:metabolism; D001711:Biotransformation; D002855:Chromatography, Thin Layer; D003514:Cyclohexylamines / Q000378:metabolism*; D003640:Dealkylation; D003641:Deamination; D004285:Dogs; D005260:Female; D000882:Haplorhini; D006801:Humans; D006900:Hydroxylation; D008253:Macaca mulatta; D008297:Male; D010276:Parasympatholytics / Q000378:metabolism*; D051381:Rats
chemical_list: D001559:Benzhydryl Compounds; D003514:Cyclohexylamines; D010276:Parasympatholytics
vernacular_title: Metabolismus von Pramiverin