title: Double blind comparison of fentanyl and sulfentanil in anesthesia.
abstract: In a double-blind experiment fentanyl and sulfentanil were compared using three different anesthesia schedules. Only interventions of long duration were selected. In all three systems induction was carried out with 0.5 mg fentanyl or 0.05 mg sulfentanil, followed by etomidate and a muscle relaxant. Anesthesia was maintained with nitrous oxide and with repeated standard injection of the narcotic. In a first group reinjections always consisted of 0.1 mg of fentanyl or 0.01 mg of sulfentanil. In a second series reinjections were done with 0.5 mg of fentanyl or 0.05 mg of sulfentanil. In the third group the same reinjection schedule as in the first group was followed, but immediately after induction an injection of 1.25 mg of droperidol was administered. Both substances were compared as to their analgesic potency and their potential influences on hemodynamics. Special attention was also paid to postoperative ventilation and vigilance.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000768:Anesthesia, General / Q000379:methods*; D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005045:Etomidate / Q000627:therapeutic use; D005260:Female; D005283:Fentanyl / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced; D009609:Nitrous Oxide / Q000627:therapeutic use; D010197:Pancuronium / Q000627:therapeutic use; D012119:Respiration / Q000187:drug effects; D013390:Succinylcholine / Q000627:therapeutic use; D013997:Time Factors; D014839:Vomiting / Q000139:chemically induced; D014851:Wakefulness / Q000187:drug effects
chemical_list: D013390:Succinylcholine; D010197:Pancuronium; D009609:Nitrous Oxide; D005283:Fentanyl; D005045:Etomidate