title: Genetic regulation of the expression of catalase activity in murine red blood cells.
abstract: The specific activity (k'1) and concentration of red blood cell catalase from four inbred strains of mice (BALB/c, C57BL, C57BL/6, and NBL) were measured to determine the mechanisms responsible for interstrain variations in enzyme activity. The specific activities of RBC catalase in NBL and the C57BL sublines are equal (2.5 x 10(7) M-1 sec-1), while that of BALB/c (4.0 x 10(7) M-1 sec-1) is 67% greater. The relative concentration of catalase is approximately 30% lower in NBL erythrocytes compared to the other three strains. The activity of BALB/c RBC catalase is due to a high k'1 coupled with a high intracellular concentration; RBC catalase activity in the C57BL sublines is the result of a low k'1 and high concentration. A low k'1 and a low concentration are responsible for the low catalase activity levels found in NBL erythrocytes.
mesh_terms: D000818:Animals; D002374:Catalase / Q000097:blood* / Q000276:immunology; D004912:Erythrocytes / Q000201:enzymology*; D005779:Immunodiffusion; D051379:Mice; D008815:Mice, Inbred Strains; D008967:Molecular Biology; D011233:Precipitin Tests; D013045:Species Specificity
chemical_list: D002374:Catalase