Familial polyposis.
Familial polyposis is a genetically-transmitted disease characterized by multiple adenomatous colorectal polyps and a high risk for development of adenocarcinoma. Familial polyposis and Gardner's syndrome should be differentiated from other penetically-linked polyposis syndromes lacking a predisposition for cancer. Total colectomy and ileorectal anastomosis, aggressive follow-up and intensive surveillance of non-polyp bearing relatives can reduce the risk of developing cancer. From an epidemiologic point of veiw, polyposis is a valuable model for the study of the interaction of genetic and environmental factors in the genesis of colon cancer.
D000328:Adult; D000367:Age Factors; D003110:Colonic Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000601:surgery; D004777:Environment; D005191:Family Characteristics; D006801:Humans; D007417:Intestinal Polyps / Q000175:diagnosis / Q000235:genetics* / Q000601:surgery; D009365:Neoplasm Regression, Spontaneous; D010641:Phenotype; D012004:Rectal Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000601:surgery; D012306:Risk; D013577:Syndrome