Histochemical and ultrastructural studies of calcification in the kidneys and the adrenal glands of rats and baboons fed a nephrocalcinogenic diet.
Long-term feeding experiments were conducted with young rats and young baboons (Papio ursinus). The effects of wxperimental diets, unbalanced in respect of magnesium and phosphorus, on the structural and ultrastructural appearance of the kidneys and the adrenals, were compared with those of a control diet. It was found, firstly, that in both species feeding of the unbalanced diets resulted in the formation of calcified structures in the kidneys and, secondly, that the formation of calcified structures in the kidneys had been initiated in different ways in the two species, viz. in the rat in the tubular epithelial cells and in the baboon in invading globule leucocytes. Thirdly, in the baboons fed on the unbalanced diet, calcified structures were found in the endothelial cells of the sinusoids of the adrenal cortex, while no calcification was evident in the adrenals of the rats fed on the unbalanced diet.
D000307:Adrenal Gland Diseases / Q000378:metabolism / Q000473:pathology*; D000311:Adrenal Glands / Q000032:analysis / Q000648:ultrastructure*; D000818:Animals; D002114:Calcinosis / Q000378:metabolism / Q000473:pathology*; D002118:Calcium / Q000032:analysis; D004032:Diet; D000882:Haplorhini; D006651:Histocytochemistry; D007668:Kidney / Q000032:analysis / Q000648:ultrastructure*; D007674:Kidney Diseases / Q000378:metabolism / Q000473:pathology*; D008297:Male; D010215:Papio; D051381:Rats
D002118:Calcium