[Sensitivity of isolated rabbit articular chrondrocytes to the somatomedin activity of human serum].
Rabbit articular chondrocytes, isolated and incubated in vitro, incorporate tritium-labelled thymidine. Thymidine incorporation is stimulated by normal human serum, this effect being related to serum concentration and increased by addition of poly-DL-ornithine. The stimulatory effect of the serum from hypopituitary dwarfs is low and is not increased by poly-DL-ornithine.
D000818:Animals; D002358:Cartilage, Articular / Q000187:drug effects*; D002478:Cells, Cultured; D004261:DNA Replication / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004393:Dwarfism, Pituitary / Q000097:blood; D013006:Growth Hormone / Q000502:physiology; D009952:Ornithine / Q000494:pharmacology; D011817:Rabbits; D013002:Somatomedins / Q000097:blood / Q000494:pharmacology*; D013268:Stimulation, Chemical; D013936:Thymidine / Q000378:metabolism
D013002:Somatomedins; D013006:Growth Hormone; D009952:Ornithine; D013936:Thymidine
Sensibilité des chondrocytes articulaires de lapin isolés à l'activité somatomédine du sérum humain