Antibodies mediating type I skin test reactions to polysaccharide and protein antigens of Candida albicans.
Immediate, type I, prick test reactions in man to purified fractions of Candida albicans group A were mediated by different classes of antibody. The allergens were the cell-wall polysaccharide, mannan, and 'purified' cytoplasmic protein fraction, free of mannan, prepared by passage through Sepharose-concanavalin-A. Passive transfer tests in the monkey gave immediate reactions, (1) to the purified, cytoplasmic, protein mediated by heat-labile long-term sensitizing antibody, and (2) to the polysaccharide, mannan, mediated by heat-stable short-term sensitizing antibody.
D000818:Animals; D000937:Antigen-Antibody Reactions; D000946:Antigens, Fungal; D002176:Candida albicans / Q000276:immunology*; D005656:Fungal Proteins / Q000276:immunology*; D006168:Guinea Pigs; D000882:Haplorhini; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D008351:Mannans / Q000276:immunology*; D011134:Polysaccharides / Q000276:immunology*; D012882:Skin Tests
D000946:Antigens, Fungal; D005656:Fungal Proteins; D008351:Mannans; D011134:Polysaccharides; D007073:Immunoglobulin E