title: Effects of ethylenediaminetetraacetic acid (EDTA) and diethylenetriaminepentaacetic acid (DTPA) derivatives on penetration of ytterbium-169 and cerium-144 into the rat offspring.
abstract: Effects of ethylenediaminetetraacetic acid (EDTA) and diethylenetriaminepentaacetic acid (DTPA) derivatives on penetration of ytterbium-169 and cerium-144 into the rat offspring. Acta Physiol. Pol., 1976, 27 (2): 175-181. Penetration of radioactive ytterbium-169 and cerium-144 into fetuses was determined at the end of pregnancy and penetration into the organism of suckling rats was studied during feeding with the milk of exposed mothers when EDTA or DTPA derivatives were being administered. Injection of ytterbium-169 as a complex with EDTA or DTPA or injection of Na2Ca EDTA or Na3Ca DTPA 1h after administration of cerium-144 to mothers reduced penetration of both radionuclides into offsprings in relation to the animals receiving no complex compounds. It was observed that the action of DTPA was stronger than that of EDTA. Passage of ytterbium with milk and across the placenta was greater than the passage of cerium.
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001942:Breast Feeding; D002563:Cerium / Q000378:metabolism*; D004492:Edetic Acid / Q000494:pharmacology*; D005260:Female; D008431:Maternal-Fetal Exchange / Q000187:drug effects; D004369:Pentetic Acid / Q000494:pharmacology*; D011247:Pregnancy; D051381:Rats; D013997:Time Factors; D015018:Ytterbium / Q000378:metabolism*
chemical_list: D002563:Cerium; D004369:Pentetic Acid; D004492:Edetic Acid; D015018:Ytterbium