title: [A case of Franklin disease--gamma heavy chain disease].
abstract: It is reported on a case of heavy chain disease in a 41-year-old man. It is a special form of the malignant lymphoma. The clinical picture of our patient distinguishes itself by an extraordinarily long course (more than 10 years enlargement of the spleen, since more than 5 years hypogammaglobulinaemia), abdominal malignant lymphomas with hepatosplenomegaly and perhaps connected with this intermittingly appearing acute epigastric complaints as well as the signs of a severe immunoinsufficiency. Homogenic Fc-(gamma)fragments are proved only in the serum in a concentration of 0.8 g/100 ml.
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D003937:Diagnosis, Differential; D006362:Heavy Chain Disease / Q000175:diagnosis*; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000032:analysis*; D007142:Immunoglobulin gamma-Chains / Q000032:analysis*; D008223:Lymphoma / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D012186:Retroperitoneal Neoplasms / Q000175:diagnosis* / Q000188:drug therapy; D013163:Splenomegaly / Q000209:etiology
chemical_list: D000970:Antineoplastic Agents; D007143:Immunoglobulin Heavy Chains; D007142:Immunoglobulin gamma-Chains
vernacular_title: Bericht über einen Fall von Franklin-Disease-gamma-Schwerkettenkrankheit