Investigations into the effect of castration on the blood glucose profile of male and female rats treated with glibenclamide (HB 319).
In SPF-bred male and female Sprague-Dawley rats the effect of castration on the hypoglycaemic action of a single dose of glibenclamide (HB 419) was investigated. The results of castration showed no unambiguous influence on the normal blood glucose values. The effect of this sulphonyl urea, however, was considerably stimulated by castration and was prolonged in male animals. Obviously the absence of testosterone has an inhibitory effect on the activity of liver ribosomes thus causing a delay in the metabolism. Furthermore the metabolic rate depends on the testosterone value in the organism as evidenced by the differences between male and female animals. The results were ascertained statistically.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D002369:Castration; D005260:Female; D005905:Glyburide / Q000494:pharmacology*; D008297:Male; D051381:Rats; D012737:Sex Factors; D013739:Testosterone / Q000097:blood
D001786:Blood Glucose; D013739:Testosterone; D005905:Glyburide