[Biosynthetis in vitro of estrogens by an adrenal cortex tumor].
A polysecretory cortico-adrenal tumor from a 46 year old woman was incubated in presence of tritiated pregnenolone and progesterone. Nine estrogens were isolated and identified by radio-gas-chromatography. This outstanding synthesis ability was in line with the high rates of urinary estrogens found in this patient.
D000306:Adrenal Cortex Neoplasms / Q000378:metabolism*; D000310:Adrenal Gland Neoplasms / Q000378:metabolism*; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D046508:Culture Techniques; D004958:Estradiol / Q000096:biosynthesis; D004964:Estriol / Q000096:biosynthesis; D004967:Estrogens / Q000096:biosynthesis* / Q000302:isolation & purification / Q000652:urine; D004970:Estrone / Q000096:biosynthesis; D005260:Female; D006801:Humans; D006913:Hydroxysteroid Dehydrogenases / Q000378:metabolism; D008780:Methyltransferases / Q000378:metabolism; D008875:Middle Aged; D006899:Mixed Function Oxygenases / Q000378:metabolism; D011284:Pregnenolone / Q000378:metabolism; D011374:Progesterone / Q000378:metabolism
D004967:Estrogens; D004970:Estrone; D011374:Progesterone; D004958:Estradiol; D011284:Pregnenolone; D006899:Mixed Function Oxygenases; D006913:Hydroxysteroid Dehydrogenases; D008780:Methyltransferases; D004964:Estriol
Biosynthése in vitro d'oestrogénes par un cortico-surrénalome