The effects of metyrapone (Metopiron) on the half-life time of phenazone (Antipyrine) in rabbits.
The half-life time as well as the disappearance curve of phenazone from the plasma were determined in control rabbits. The same measurements were performed in rabbits which received two doses of metyrapone. No evident effect of metyrapone on phenazone metabolism could be detected under these experimental conditions.
D000818:Animals; D000983:Antipyrine / Q000097:blood / Q000378:metabolism*; D005260:Female; D006207:Half-Life; D008297:Male; D008797:Metyrapone / Q000494:pharmacology*; D011817:Rabbits
D000983:Antipyrine; D008797:Metyrapone