[Anti-inflammatory effect of hydroxy-9-ellipticine].
The anti-inflammatory activity of 9-hydroxy-ellipticine is studied through various experimental models. It is particularly interesting in the guinea-pig cutaneous erythema, in the carragenin-induced oedema and in the adjuvant-induced polyarthritis in the rat. It appears in immune or non-immune induced inflammatory responses. Its important thymolytic activity can be related to its immunosuppressive effect.
D000470:Alkaloids / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents; D001168:Arthritis / Q000188:drug therapy; D004487:Edema / Q000188:drug therapy; D004611:Ellipticines / Q000494:pharmacology / Q000627:therapeutic use*; D004890:Erythema / Q000188:drug therapy; D006099:Granuloma / Q000188:drug therapy; D006168:Guinea Pigs; D008297:Male; D051381:Rats; D012871:Skin Diseases / Q000188:drug therapy; D013950:Thymus Gland / Q000187:drug effects; D013997:Time Factors
D000470:Alkaloids; D000893:Anti-Inflammatory Agents; D004611:Ellipticines
Action anti-inflammatoire de l'hydroxy-9 ellipticine