Delayed dermal hypersensitivity in rhesus monkeys (Macaca mulatta) immunized against Plasmodium knowlesi.
Eighteen Rhesus monkeys were immunized with a fresh or lyophilized antigen preparation obtained from erythrocytes infected with Plasmodium knowlesi. Sixteen of these monkeys showed a positive delayed hypersensitivity response when subsequently skin tested with the immunizing antigen. Ten of the 16 positive reactors survived a P, knowlesi challenge, the remaining 6 showed several indications of protection. None of the 18 control monkeys gave a positive skin reaction or survived the challenging inoculum. Macro- and microscopical evidence suggests that the dermal reaction is of a delayed type. Preliminary biochemical analysis of the antigen used in this experiment is included and its significance is discussed. Hematological data is also presented.
D000818:Animals; D000941:Antigens / Q000032:analysis; D001772:Blood Cell Count; D005260:Female; D000882:Haplorhini; D006400:Hematocrit; D006968:Hypersensitivity, Delayed; D007114:Immunization; D007428:Intradermal Tests; D008253:Macaca mulatta; D008288:Malaria / Q000097:blood / Q000276:immunology*; D008297:Male; D010961:Plasmodium / Q000276:immunology*
D000941:Antigens