title: Circadian rhythms in polyamine excretion by rats bearing an immunocytoma.
abstract: Large-amplitude circadian rhythms were observed in the urinary excretion of polyamines by rats bearing an immunocytoma. Control animals excreted polyamines at a lower rate but also with marked circadian variation. In confirmation of earlier observations, light-chain excretion by the tumor-bearing rats also exhibited a circadian rhythm, superimposed on an increasing trend. The potential of these rhythms as markers for the chronotherapy of cancer is noted.
mesh_terms: D000818:Animals; D002103:Cadaverine / Q000652:urine; D002940:Circadian Rhythm; D004032:Diet; D007147:Immunoglobulin Light Chains / Q000652:urine; D008297:Male; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000652:urine; D010954:Plasmacytoma / Q000188:drug therapy / Q000652:urine*; D011073:Polyamines / Q000652:urine*; D011700:Putrescine / Q000652:urine; D051381:Rats; D013095:Spermidine / Q000652:urine; D013096:Spermine / Q000652:urine
chemical_list: D007147:Immunoglobulin Light Chains; D011073:Polyamines; D013096:Spermine; D002103:Cadaverine; D013095:Spermidine; D011700:Putrescine