On the role of tumor cell surface in the accumulation of radioisotopes.
The effects of electrical charge and structural modifications of the ascites tumor cell surface on the uptake of several radiocompounds have been investigated. Changes in its electrical surface charge provoke variations in the radioactivity incorporation which appear to be selective for chelated or ionic radioisotopes. The release of a part of the cell "coat" by EDTA affects profoundly the incorporation of radioisotopes in a process which seems to be related to cell membrane permeability changes. The relationships between cell surface changes and radiocompounds accumulation are discussed.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism*; D002463:Cell Membrane Permeability / Q000187:drug effects; D004492:Edetic Acid / Q000494:pharmacology; D006023:Glycoproteins / Q000378:metabolism; D008564:Membrane Potentials; D008565:Membrane Proteins / Q000378:metabolism; D011070:Poly I-C / Q000494:pharmacology; D011107:Polylysine / Q000494:pharmacology; D011868:Radioisotopes; D051381:Rats; D014357:Trypsin / Q000494:pharmacology
D006023:Glycoproteins; D008565:Membrane Proteins; D011868:Radioisotopes; D011107:Polylysine; D004492:Edetic Acid; D014357:Trypsin; D011070:Poly I-C