Studies on J-chain biosynthesis in tumours producing immunoglobulins in NZB mice.
Investigation of biosynthesis of J chain in plasmacytomas induced in NZB mice revealed that this protein was not only synthesized in the cells that produce polymer immunoglobulin A but also in those that produce immunoglobulin G monomer. It was also found that protein similar to J chain of BALB/c-mice was associated with polymer immunoglobulin A but not with immunoglobulin G of NZB mouse myeloma proteins.
D000818:Animals; D007070:Immunoglobulin A / Q000032:analysis / Q000096:biosynthesis*; D007074:Immunoglobulin G / Q000032:analysis / Q000096:biosynthesis*; D007144:Immunoglobulin J-Chains / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis; D051379:Mice; D008814:Mice, Inbred NZB; D009194:Myeloma Proteins / Q000032:analysis; D009374:Neoplasms, Experimental / Q000378:metabolism; D010954:Plasmacytoma / Q000032:analysis / Q000276:immunology / Q000378:metabolism*
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007144:Immunoglobulin J-Chains; D007075:Immunoglobulin M; D009194:Myeloma Proteins