title: Exocrine pancreatic function in protein-deficient patas monkeys studied by means of a test meal and an indirect pancreatic function test.
abstract: Exocrine pancreatic secretion was studied in 9 patas monkeys before and during protein depletion, and in 4 of them also during recovery from protein depletion. Pancreatic function was estimated by measuring enzymatic activities in the duodenal contents after a test meal and by determination of urinary excretion of p-aminobenzoic acid (pancreatic function test) after oral ingestion of the chymotrypsin-labile peptide N-benzoyl-L-tyrosyl-p-aminobenzoic acid. The average serum albumin dropped by 34.8% to 2.6 g per 100 ml. Significant decrease of trypsin, lipase, amylase, and chymotrypsin was observed in the duodenal samples during protein deficiency. Urinary excretion of p-aminobenzoic acid was also reduced significantly. The two tests correlated well. In 3 of 4 animals, recovery of pancreatic function was noted after refeeding a full protein diet. Pancreatic atrophy was noted in 2 animals which died. The study shows that exocrine pancreatic secretion can be seriously impaired even at a moderate protein deficiency and may not be reversibly in all instances. Therefore, function tests have to be evaluated with caution when hypoproteinemia, i.e., hypoalbuminemia, is present.
mesh_terms: D062365:Aminobenzoates / Q000378:metabolism* / Q000652:urine; D000681:Amylases / Q000032:analysis; D000818:Animals; D002918:Chymotrypsin / Q000032:analysis; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004044:Dietary Proteins; D005260:Female; D005502:Food; D000882:Haplorhini; D008049:Lipase / Q000032:analysis; D008297:Male; D010179:Pancreas / Q000503:physiopathology*; D010189:Pancreatic Juice / Q000378:metabolism*; D011488:Protein Deficiency / Q000503:physiopathology*; D012709:Serum Albumin / Q000032:analysis; D012712:Serum Globulins / Q000032:analysis; D014357:Trypsin / Q000032:analysis
chemical_list: D062365:Aminobenzoates; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004044:Dietary Proteins; D012709:Serum Albumin; D012712:Serum Globulins; D008049:Lipase; D000681:Amylases; D002918:Chymotrypsin; D014357:Trypsin