title: Comparison of lymphocyte stimulation and tuberculin skin reactivity in Mycobacterium bovis-infected Macaca mulatta.
abstract: Lymphocyte immunostimulation tests were conducted on Mycobacterium bovis-infected and tuberculin-negative rhesus macaques (Macaca mulatta), using purified protein derivative (PPD) tuberculins prepared from strains of Mycobacterium tuberculosis and Mycobacterium avium. The stimulation of lymphocytes with M tuberculosis PPD was significantly greater for the M bovis-infected macaques than for the noninfected controls (P smaller than 0.05). The response of lymphocytes from M bovis-infected macaques to stimulation with M tuberculosis PPD was greater than the responses to stimulation with M avium PPD (P smaller than 0.01). The results of in vitro lymphocyte stimulation and tuberculin skinreactivity were similar.
mesh_terms: D000818:Animals; D037102:Lectins / Q000494:pharmacology; D008213:Lymphocyte Activation; D008251:Macaca; D008253:Macaca mulatta; D008992:Monkey Diseases / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D009163:Mycobacterium bovis / Q000276:immunology; D009169:Mycobacterium tuberculosis / Q000276:immunology; D013997:Time Factors; D014374:Tuberculin Test; D014376:Tuberculosis / Q000175:diagnosis / Q000276:immunology / Q000662:veterinary*
chemical_list: D037102:Lectins