[Glycogen and enzymes involved in its biosynthesis in rat liver during liver carcinogenesis caused by diethylnitrosamine].
An attempt was made to correlate variations in the level of glycogen during chemically induced carcinogenesis (DENA) with changes in the activity of enzymes participating in biosynthesis of this polysaccharide (UDPG-glycosensynthetase, phosphoglucomutase, UDPG-pyrophosphorylase). It is found that in DENA action in the rat liver two phases may be sharply differentiated--initial (the 1st month) with marked alterations in the content of glycogen and the activity of related enzymes, and final one (4-6th month) which is characterized by reduction of glycogen content, a new sharp rise in the activity of phosphoglucomutase and UDPG-pyrophosphorylase, and somewhat decreased activity of UDPG-glycogensynthetase, as compared with the initial values.
D000818:Animals; D004052:Diethylnitrosamine; D006006:Glycogen Synthase / Q000378:metabolism*; D008112:Liver Glycogen / Q000378:metabolism*; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000378:metabolism; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000378:metabolism; D009602:Nitrosamines; D009713:Nucleotidyltransferases / Q000378:metabolism*; D010733:Phosphoglucomutase / Q000378:metabolism*; D051381:Rats; D005957:UTP-Glucose-1-Phosphate Uridylyltransferase / Q000378:metabolism*
D008112:Liver Glycogen; D009602:Nitrosamines; D004052:Diethylnitrosamine; D006006:Glycogen Synthase; D009713:Nucleotidyltransferases; D005957:UTP-Glucose-1-Phosphate Uridylyltransferase; D010733:Phosphoglucomutase
Glikogen i fermenty ego biosinteza v pecheni krys v protsesse gepatokantserogeneza vyzvannogo diétilnitrozaminon