[Proceedings: Development and clinical applications of radioimmunoassays specific to luteinizing hormone and human chorionic gonadotropin (author's transl)].
Antisera directed against the beta subunit of human Luteinizing Hormone (h. LH) and Chorionic Gonadotropin (HCG) were made totally specific to either gonadotropin by adsorbing cross-reacting antibodies. Simple absorption in solution or immunosorption on solid phase were employed. Pituitary functions were examined during pregnancy and until three weeks following delivery h.LH and HCG were assayed before and after injection of Luteinizing Hormone Releasing Hormone (LH-RH). Similiarly TSH was assayed in a homologous TSH beta subunit system before and after injection Thyrotropin Releasing Hormone (TRH). No pituitary release of LH was observed after LH-RH in our experimental conditions while TRH induced a surge of pituitary TSH in the blood.
D006063:Chorionic Gonadotropin / Q000097:blood*; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood*; D011247:Pregnancy; D013972:Thyrotropin / Q000097:blood; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology
D006063:Chorionic Gonadotropin; D007987:Gonadotropin-Releasing Hormone; D013973:Thyrotropin-Releasing Hormone; D007986:Luteinizing Hormone; D013972:Thyrotropin
Dosages spécifiques des hormones lutéinisante et gonadotrope chorionique. Développement et applications cliniques