The possible deleterious effects of the intramyometrial injection of hypertonic urea.
Hypertonic urea has been shown to be an effective midtrimester abortifacient. Although safer than hypertonic saline when injected intravascularly, it has not been compared to saline in the case of inadvertent intramyometrial injection. This report documents that intramyometrial injection of hypertonic urea will result in the same type of muscle necrosis as that produced by saline.
D000019:Abortifacient Agents / Q000009:adverse effects*; D000020:Abortifacient Agents, Nonsteroidal / Q000009:adverse effects*; D000818:Animals; D005260:Female; D000882:Haplorhini; D006982:Hypertonic Solutions / Q000008:administration & dosage / Q000009:adverse effects*; D007267:Injections; D008253:Macaca mulatta; D009215:Myometrium / Q000473:pathology; D009336:Necrosis; D011247:Pregnancy; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage / Q000009:adverse effects; D014508:Urea / Q000008:administration & dosage / Q000009:adverse effects*; D014599:Uterus
D000019:Abortifacient Agents; D000020:Abortifacient Agents, Nonsteroidal; D006982:Hypertonic Solutions; D012462:Saline Solution, Hypertonic; D014508:Urea