[The effect of prolonged injestion of paraffin oil in pigs: selective retention and interference with cholesterol metabolism].
Hydrocarbons administered to the pig as paraffin oil fix preferentially in the liver, and the existence of a selective filtration mechanism can be supposed. Moreover a significant increase of the level of squalene is observed in adipose tissue and liver; it could correspond to an inhibition of the cholesterol synthesis following vitamin A deficiency due to perturbation of intestinal absorption.
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D002784:Cholesterol / Q000378:metabolism*; D002849:Chromatography, Gas; D003864:Depression, Chemical; D005724:Ganglia / Q000378:metabolism; D006838:Hydrocarbons / Q000378:metabolism; D007408:Intestinal Absorption / Q000187:drug effects; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008643:Mesentery; D009132:Muscles / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D010232:Paraffin / Q000378:metabolism* / Q000494:pharmacology; D013154:Spleen / Q000378:metabolism; D013185:Squalene / Q000378:metabolism; D013552:Swine / Q000378:metabolism*; D013997:Time Factors; D014801:Vitamin A / Q000378:metabolism
D006838:Hydrocarbons; D014801:Vitamin A; D013185:Squalene; D010232:Paraffin; D002784:Cholesterol
Effet de l'ingestion prolongée d'huile de paraffine chez le Porc: rétention sélective, interférence avec le métabolisme du cholestérol