Circadian variations in 32P uptake of DMBA-induced mammary tumour and Walker carcinosarcoma in rats.
The 32P uptake in a mammary tumour induced by DMBA and in the Walker 256 carcinosarcoma was measured by external GM -tubes. The uptake was significantly higher than in the skin. During exposure to a synchronized light regime a circadian variation was present in the 32P uptake of the hormone-dependent DMBA-induced tumour. The maximal 32P uptake was in the dark period, in which the highest temperature in the tumour has also been found (Møoller and Bojsen, 1975). In the hormone-independent Walker 256 carcinosarcoma there was no periodicity in 32P uptake. No variation in 32P uptake was registered in the skin of normal controls or in tumour-bearing rats.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D001831:Body Temperature; D002279:Carcinoma 256, Walker / Q000139:chemically induced / Q000378:metabolism*; D002940:Circadian Rhythm; D003624:Darkness; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000378:metabolism*; D010758:Phosphorus / Q000378:metabolism*; D051381:Rats; D012867:Skin / Q000378:metabolism
D010758:Phosphorus; D015127:9,10-Dimethyl-1,2-benzanthracene