[Influence of colchicine on the effects of acetylcholine and pilocarpine on isolated ventricle of the ammocete Lampetra planeri (Bloch)].
Colchicine inhibits the positive chronotopic effects of acetylcholine and of pilocarpine of the isolated ammocoete heart ventricle. This positive chronotropic effect is due to a release of catecholamines from the chromaffin cells of the lamprey heart. The action of colchicine, which does not result from its curare-like effect, suggests that acetylcholine induces release of catecholamines by exycytosis.
D000109:Acetylcholine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D000818:Animals; D002395:Catecholamines / Q000502:physiology; D002838:Chromaffin System / Q000187:drug effects / Q000502:physiology; D003078:Colchicine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005089:Exocytosis / Q000187:drug effects; D005399:Fishes / Q000502:physiology*; D006339:Heart Rate / Q000187:drug effects*; D006352:Heart Ventricles / Q000187:drug effects; D066298:In Vitro Techniques; D007798:Lampreys / Q000502:physiology*; D009489:Neurosecretion / Q000187:drug effects; D010862:Pilocarpine / Q000037:antagonists & inhibitors* / Q000494:pharmacology
D002395:Catecholamines; D010862:Pilocarpine; D000109:Acetylcholine; D003078:Colchicine
Influence de la colchicine sur les effets de l'acétylcholine et de la pilocarpine sur le ventricule isolé de l'ammoncète de Lampetra planeri (Bloch)