[A case of atypical myeloblasts; a RNA leukemia].
In a 53-year-old female patient, a tumor localized in the nasopharyngeal cavity together with hematologic features of acute paramyeloblastic leukemia were observed. More than 70% blast cells contained giant intracytoplasmic inclusions which have been found to be strongly pyroninophilic. The electron-microscopic study revealed big agglomerations of ribosomal RNA inside of pseudofibrillar structures of the cytoplasma. The possibility of a new nosological entity should be envisaged.
D001853:Bone Marrow / Q000473:pathology; D001854:Bone Marrow Cells; D002466:Cell Nucleolus / Q000648:ultrastructure; D003593:Cytoplasm / Q000378:metabolism; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000097:blood* / Q000150:complications; D008875:Middle Aged; D008928:Mitochondria / Q000648:ultrastructure; D009303:Nasopharyngeal Neoplasms / Q000150:complications; D010544:Peroxidases; D012334:RNA, Neoplasm / Q000378:metabolism; D012335:RNA, Ribosomal / Q000378:metabolism; D012270:Ribosomes / Q000648:ultrastructure; D014617:Vacuoles / Q000648:ultrastructure
D012334:RNA, Neoplasm; D012335:RNA, Ribosomal; D010544:Peroxidases
Un cas de myélose aiguë atypique: une leucémie arn