title: [Continuous local application of cytostatics for bronchial carcinoma and mediastinal lymph node metastasisization (author's transl)].
abstract: A carcinostatic substance (5-fluorouracil) was instilled into the mediastinal lymph nodes, the pleural cavity or the internal thoracic artery by continuous perfusion before operation on patients with bronchial carcinoma. Degenerative changes could be demonstrated histologically in the cancer cells in the lymph node metastases. This method was also effective for the controlateral lymph node metastases. As a treatment additional to operation, it may improve the chances of survival.
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy; D001984:Bronchial Neoplasms / Q000188:drug therapy*; D002277:Carcinoma / Q000188:drug therapy; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D010478:Chemotherapy, Cancer, Regional Perfusion; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use*; D006048:Gold Colloid, Radioactive; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis / Q000188:drug therapy*; D008479:Mediastinal Neoplasms / Q000378:metabolism / Q000473:pathology; D011379:Prognosis; D013895:Thoracic Arteries
chemical_list: D006048:Gold Colloid, Radioactive; D005472:Fluorouracil
vernacular_title: Lokale Daueranwendung von Zytostatika bei Bronchialkarzinom und mediastinalen Lymphknoten-metastasen