Effect of malnutrition on cortisol-binding protein in the lens of cynomolgus monkeys.
A cortisol-binding protein exists in the lens of cynomolgus monkeys as in other species. The cortisol-binding capacity decreased markedly with a diet either moderately or severely depleted of protein, even if the diet was later changed to a normal diet during infancy. This suggests that malnutrition may cause insufficient synthesis of the important factors controlling the inactivation of steroid hormone in the lens.
D000818:Animals; D000831:Animals, Newborn; D003459:Crystallins / Q000378:metabolism*; D004044:Dietary Proteins; D005260:Female; D000882:Haplorhini; D006854:Hydrocortisone / Q000378:metabolism*; D007774:Lactation; D007908:Lens, Crystalline / Q000378:metabolism*; D008252:Macaca fascicularis; D008297:Male; D011247:Pregnancy; D011488:Protein Deficiency / Q000178:diet therapy / Q000378:metabolism*; D014156:Transcortin / Q000378:metabolism*; D014886:Weaning
D003459:Crystallins; D004044:Dietary Proteins; D014156:Transcortin; D006854:Hydrocortisone