Anti-heparin activity of a macroglobulin from a patient with breast adenocarcinoma.
We describe a case of IgM paraproteinemia, whose macroblogulin reacted anomalously with heparin. Anti-heparin activity of the paraprotein was suggested by insensibility of the patient's plasma to heparin in heparin-thrombin clotting time. Moreover, the presence of heparin in the medium markedly reduced the inhibitory effect of the paraprotein on platelet aggregation by ADP.
D000230:Adenocarcinoma / Q000097:blood*; D001777:Blood Coagulation / Q000187:drug effects; D001943:Breast Neoplasms / Q000097:blood*; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects; D006494:Heparin Antagonists / Q000097:blood*; D006801:Humans; D007075:Immunoglobulin M / Q000378:metabolism; D008259:Macroglobulins / Q000378:metabolism* / Q000494:pharmacology; D008875:Middle Aged; D010265:Paraproteinemias / Q000378:metabolism; D010974:Platelet Aggregation / Q000187:drug effects; D013268:Stimulation, Chemical
D006494:Heparin Antagonists; D007075:Immunoglobulin M; D008259:Macroglobulins