title: The effect of cobalt on haemoglobin synthesis in primate reticulocytes.
abstract: The effect of cobalt on haemoglobin synthesis was studied in reticulocytes obtained from marmosets, new world monkeys. By means of different inhibitors the conditions necessary for either cobalt-induced stimulation or inhibition were determined. Cobalt-induced inhibition of globin synthesis was not reversible by the addition of either delta-amino levulinic acid or haem. Globia synthesis, however, in iron-deficient reticulocytes was stimulated by the addition of cobalt. Cobalt did not apparently require complexing with protoporphyrin for activity, since the effect was observed whether the haem-biosynthetic pathway was inhibited or not. The data have been interpreted to suggest cobalt operates by affecting a rate controlling step in the synthesis of globin.
mesh_terms: D000622:Aminolevulinic Acid / Q000378:metabolism; D000818:Animals; D002143:Callitrichinae; D003035:Cobalt / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005914:Globins / Q000096:biosynthesis; D000882:Haplorhini; D006418:Heme / Q000096:biosynthesis; D006454:Hemoglobins / Q000096:biosynthesis*; D007501:Iron / Q000494:pharmacology; D007538:Isoniazid / Q000494:pharmacology; D012156:Reticulocytes / Q000378:metabolism*
chemical_list: D006454:Hemoglobins; D003035:Cobalt; D006418:Heme; D000622:Aminolevulinic Acid; D005914:Globins; D007501:Iron; D007538:Isoniazid