Sulfolane-induced convulsions in rodents.
In rodents oral or parenteral administration of sulfolane (tetrahydrothiophene-1,1-dioxide) produced hyperactivity, followed by clonic-tonic convulsions. The analeptic effects of sulfolane were nearly additive with those of Metrazol. When injected simultaneously with pentobarbital, sulfolane decreased pentobarbital sleeping time in mice. But sulfolane increased sleeping time when the barbiturate was administered 1 hr after sulfolane.
D000284:Administration, Oral; D000818:Animals; D003499:Cyclic S-Oxides / Q000494:pharmacology / Q000633:toxicity; D004285:Dogs; D004347:Drug Interactions; D006168:Guinea Pigs; D000882:Haplorhini; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010424:Pentobarbital / Q000494:pharmacology; D010433:Pentylenetetrazole / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D012453:Saimiri; D012640:Seizures / Q000139:chemically induced*; D012890:Sleep / Q000187:drug effects; D013876:Thiophenes / Q000378:metabolism / Q000494:pharmacology* / Q000633:toxicity; D013997:Time Factors
D003499:Cyclic S-Oxides; D013876:Thiophenes; D010424:Pentobarbital; D010433:Pentylenetetrazole