Prophylaxis of bladder tumor implantation. Intravesical and systemic chemotherapy.
Several antitumor agents have been evaluated for their effectiveness in reducing the implantation and progressive growth of transitional cell carcinoma in an animal model. This system allows the evaluation of both the topical cytotoxic action as well as the systemic toxicity of the drugs given intravesically. Systemic cyclophosphamide and intravesical epipodophyllotoxin significantly reduced the incidence of tumor cell implantation.
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D002295:Carcinoma, Transitional Cell / Q000139:chemically induced / Q000517:prevention & control*; D004195:Disease Models, Animal; D004317:Doxorubicin / Q000008:administration & dosage / Q000627:therapeutic use / Q000633:toxicity; D005260:Female; D008770:Methylnitrosourea / Q000008:administration & dosage / Q000627:therapeutic use / Q000633:toxicity; D051379:Mice; D008809:Mice, Inbred C3H; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental; D011034:Podophyllotoxin / Q000008:administration & dosage / Q000627:therapeutic use / Q000633:toxicity; D013852:Thiotepa / Q000008:administration & dosage / Q000627:therapeutic use / Q000633:toxicity; D001743:Urinary Bladder; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced / Q000517:prevention & control*
D000970:Antineoplastic Agents; D008770:Methylnitrosourea; D004317:Doxorubicin; D013852:Thiotepa; D011034:Podophyllotoxin