[Antiheparin immunoglobulin in malignant lymphoma with hypertriglyceridemia, in the hamster].
A massive hypertriglyceridemia associated with low post heparin lipolytic activity, was demonstrated during the growth of a transplanted lymphoma in Hamsters. An immunoglobulin, with high anti-heparin activity, was extracted from the tumor. It could inhibit both the anti-thrombin and prolipase activity of heparin. The role of this anti-heparin immunoglobulin in triglyceride metabolism allows us to consider the hypertriglyceridemia of lymphoma-bearing Hamsters as one of the two previously described types of auto-immune hyperlipidemia.
D000818:Animals; D001323:Autoantibodies; D001780:Blood Coagulation Tests; D006224:Cricetinae; D006493:Heparin / Q000276:immunology; D006494:Heparin Antagonists / Q000302:isolation & purification*; D006949:Hyperlipidemias / Q000209:etiology / Q000276:immunology*; D007136:Immunoglobulins / Q000302:isolation & purification*; D066298:In Vitro Techniques; D008071:Lipoprotein Lipase / Q000097:blood; D008223:Lymphoma / Q000032:analysis / Q000150:complications / Q000276:immunology*; D009374:Neoplasms, Experimental; D014280:Triglycerides / Q000097:blood*
D001323:Autoantibodies; D006494:Heparin Antagonists; D007136:Immunoglobulins; D014280:Triglycerides; D006493:Heparin; D008071:Lipoprotein Lipase
Une immunoglobuline anti-héparine chez le hamster hypertriglycéridémique porteur d'un lymphome malin