title: Beta-lactam antibiotics with N-oxide side chains. 1. Quinoxaline N-oxides.
abstract: A series of penicillin derivatives of quinoxaline di-N-oxide carboxylic acids was prepared. These compounds were prepared from the acid chlorides and mixed anhydrides of the quinoxaline di-N-oxides. The compounds prepared exhibited minimal antibacterial activity against gram-negative organisms.
mesh_terms: D000818:Animals; D003497:Cyclic N-Oxides / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use; D051379:Mice; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D011512:Proteus Infections / Q000188:drug therapy; D011513:Proteus mirabilis; D011552:Pseudomonas Infections / Q000188:drug therapy; D011550:Pseudomonas aeruginosa; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D012484:Salmonella paratyphi B / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D003497:Cyclic N-Oxides; D010406:Penicillins; D011810:Quinoxalines