Suppression by thyrotropin-releasing hormone (TRH) of growth hormone release induced by arginine and insulin-induced hypoglycemia in man.
Plasma growth hormone (GH) levels were significantly increased following L-arginine (30 g) infusion or insulin (0.1 U/kg body wt)-induced hypoglycemia in normal men. When synthetic thyrotropin-releasing hormone (TRH) (1 mg) was infused intravenously for 150 min, beginning 30 min before arginine or insulin administration, GH responses to arginine and insulin were significantly blunted with a mean (+/- SE) percentage inhibition of 80.1 +/- 8.8% and 30.6 +/- 10.3%, respectively. These results suggest a possible inhibitory effect of TRH on GH secretion in man.
D000328:Adult; D001120:Arginine; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced* / Q000503:physiopathology; D007328:Insulin; D008297:Male; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*
D007328:Insulin; D013973:Thyrotropin-Releasing Hormone; D013006:Growth Hormone; D001120:Arginine