Aging changes in intervertebral discs and spondylosis in Chinese hamsters.
Vertebrae and intervertebral discs of Chinese hamsters, a species of rodents that develop spontaneous diabetes, were investigated for age-linked changes and for the occurrence of spondylosis. Aging changes in the intervertebral discs were similar in diabetic and nondiabetic animals. The incidence of spondylosis was significantly increased and its onset was accelerated in the diabetic animals. The mechanisms operative in the pathogenesis of the lesions and their relation to the human disease are discussed.
D000375:Aging; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D006224:Cricetinae; D048909:Diabetes Complications; D016883:Diabetic Ketoacidosis / Q000209:etiology; D004195:Disease Models, Animal; D005260:Female; D007328:Insulin / Q000097:blood; D007403:Intervertebral Disc / Q000473:pathology*; D008159:Lumbar Vertebrae / Q000473:pathology; D008297:Male; D012737:Sex Factors; D013128:Spinal Osteophytosis / Q000150:complications* / Q000473:pathology; D013904:Thoracic Vertebrae / Q000473:pathology
D001786:Blood Glucose; D007328:Insulin