[Results of a study of live mumps vaccine from strain L-3 produced by the Moscow research institute for viral preparations. Characteristics of the vaccine].
For some years the Moscow Research Institute of Virus Preparations carried out studies concerned with the elaboration of conditions for production and control of mumps vaccine from the Leningrad-3 (L-3) strain under experimental production conditions. Twenty nine batches of the vaccine were prepared, tested and studied in extensive field trials. The paper presents the optimal conditions for the preparation of the live mumps vaccine from the L-3 strain in Japanese quail embryo cell cultures. In monkey experiments the L-3 strain was shown to have no neurovirulence. The system of biological control for the mumps vaccine permits to release the preparation meeting the current requirements for safety of live tissue culture parenteral vaccines. The data on the stability of the mumps vaccine from the L-3 strain are presented.
D000818:Animals; D002478:Cells, Cultured; D002642:Chick Embryo; D006168:Guinea Pigs; D000882:Haplorhini; D008253:Macaca mulatta; D051379:Mice; D009107:Mumps / Q000517:prevention & control*; D009108:Mumps Vaccine / Q000302:isolation & purification / Q000592:standards; D009109:Mumps virus / Q000254:growth & development; D014611:Vaccination; D014613:Vaccines, Attenuated; D014776:Virus Cultivation
D009108:Mumps Vaccine; D014613:Vaccines, Attenuated
Rezul'taty izucheniia zhivoĭ parotitnoĭ vaktsiny iz shtamma L-3 proizvodstva Moskovskogo nauchno-issledovatel'skogo instituta virusnykh preparatov. Kharakteristika vaktsiny