[Demonstration of the action of methyl benzimidazole 2 yl carbamate (MCB) and methyl(5(2 thienyl carbonyl) 1 H benzimidazole 2 yl carbamate) (R17934) on the nucleus of Physarum polycephalum (Myxomycetes)].
The toxicity of these compounds was determined in the amoebae and plasmodia. An electron microscopic study shows an increase in nuclear size which is in agreement with the increase of the total amount of DNA. Microtubules are present but they are not organized in a normal mitotic apparatus. Some other nuclear abnormalities are described.
D001562:Benzimidazoles / Q000494:pharmacology*; D002219:Carbamates / Q000494:pharmacology; D002466:Cell Nucleolus / Q000187:drug effects; D002467:Cell Nucleus / Q000187:drug effects*; D004247:DNA / Q000096:biosynthesis; D008854:Microscopy, Electron; D008856:Microscopy, Fluorescence; D008870:Microtubules / Q000187:drug effects; D008938:Mitosis / Q000187:drug effects; D009235:Myxomycetes / Q000648:ultrastructure*; D010804:Physarum / Q000648:ultrastructure*; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis
D001562:Benzimidazoles; D002219:Carbamates; D012313:RNA; D004247:DNA
Mise en évidence de l'action du méthyl benzimidazole 2 yl carbamate (MBC) et du méthyl[5(2 thiényl carboyl) 1 H benzimidazole 2 yl carbomate] (R 17934) sur le noyau de Physarum polycephalum (Myxomycètes)