Isolation of three new antibiotics, thiocillins I, II and III, related to micrococcin P. Studies on antibiotics from the genus Bacillus. VIII.
Thiocillins I and II were isolated from the culture broth of Bacillus cereus G-15, and thiocillins II and III from that of Bacillus badius AR-91. Also, the former two were probably produced by Bacillus megatherium I-13. These antibiotics active against Gram-positive bacteria are soluble in a mixture of chloroform and methanol, show characteristic ultraviolet absorptions (maxima at ca. 275 nm and ca. 348 nm), and contain a high content of sulfur, as much as approximately 15%. They are related to each other and also to micrococcin P, but differentiated by chromatographic behaviours.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology; D001409:Bacillus cereus / Q000378:metabolism; D001410:Bacillus megaterium / Q000378:metabolism; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D055598:Chemical Phenomena; D002621:Chemistry; D002855:Chromatography, Thin Layer; D051379:Mice; D010452:Peptide Biosynthesis; D010455:Peptides / Q000302:isolation & purification / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D010455:Peptides; C012574:thiocillin