Changes in cerebral blood volume and vascular mean transit time during induced cerebral seizures.
The relationship of the mean transit time of the vascular indicator C15O-labeled hemoglobin (tco) and the cerebral blood volume (CBV) as measured by stimulated x-ray fluorescence, to the mean arterial blood pressure (MABP) was examined in rhesus monkeys before and during experiment cerebral seizures. The results demonstrate a marked increase in CBV and a decrease in tco. A substantial portion of these changes is the passive accompaniment of the associated increase in MABP.
D000818:Animals; D001794:Blood Pressure; D001810:Blood Volume; D001921:Brain / Q000098:blood supply*; D002245:Carbon Dioxide / Q000097:blood; D002263:Carboxyhemoglobin; D002560:Cerebrovascular Circulation; D004827:Epilepsy / Q000139:chemically induced / Q000503:physiopathology*; D000882:Haplorhini; D008253:Macaca mulatta; D010313:Partial Pressure; D010433:Pentylenetetrazole; D013997:Time Factors
D002245:Carbon Dioxide; D002263:Carboxyhemoglobin; D010433:Pentylenetetrazole