[Determination of carcinoembryonic antigen (CEA) in patients with tumors of the large intestine. Experience with a new radioimmunoassay (author's transl)].
Specimens from 93 patients with histologically confirmed tumors of the large bowel (53 single, 40 sequential determinations) were investigated by a new CEA radioimmunoassay (double antibody method, direct serum determination). Of the single and preoperative sequential determinations 37-40% were normal (below 2.5 ng/ml), one third was intermediately elevated (2.6-15 ng/ml) and 26-28% were highly pathological leveled (over 15 ng/ml). Following operation, cases with local or regionally confined tumor showed significantly more normal or normalizing CEA levels within 1-6 weeks (17/27), whereas patients with overt metastases developed more pathological or increasingly pathological levels (8/11).
D000230:Adenocarcinoma / Q000276:immunology; D000328:Adult; D000368:Aged; D002272:Carcinoembryonic Antigen / Q000032:analysis*; D003110:Colonic Neoplasms / Q000276:immunology; D005260:Female; D006801:Humans; D007414:Intestinal Neoplasms / Q000276:immunology* / Q000601:surgery; D007420:Intestine, Large / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011182:Postoperative Care; D011379:Prognosis; D011863:Radioimmunoassay / Q000379:methods*; D012004:Rectal Neoplasms / Q000276:immunology; D012811:Sigmoid Neoplasms / Q000276:immunology
D002272:Carcinoembryonic Antigen
Bestimmungen von karzinoembryonalem Antigen bei Patienten mit Dickdarmtumoren. Erfahrungen mit einem eigenen Radioimmunoassay