Structure and biologic functions of human IgD. X. Enhancement of PHA responsiveness by anti-delta-activated lymphocytes.
Human peripheral lymphocytes with the capacity to be stimulated by anti-delta exhibited in PHA responsiveness when cultured with anti-delta 1 or 12 hr before PHA exposure over cells exposed to PHA alone. When these lymphocytes were preincubated with PHA 1 or 12 hr before anti-delta activation, no augmentation of the PHA response was seen. In addition, lymphocytes from donors with a high PHA response (low anti-delta activation) failed to show an enhancing effect on PHA responsiveness when pretreated with anti-delta. Moreover, anti-mu showed no synergistic effect on PHA responsiveness. This study is the first to indicate that anti-delta-activated cells enhance PHA responsiveness.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000494:pharmacology*; D006041:Goats / Q000276:immunology; D006801:Humans; D007072:Immunoglobulin D; D007138:Immunoglobulin delta-Chains; D007148:Immunoglobulin mu-Chains; D037102:Lectins; D008213:Lymphocyte Activation / Q000187:drug effects*
D000888:Antibodies, Anti-Idiotypic; D007072:Immunoglobulin D; D007138:Immunoglobulin delta-Chains; D007148:Immunoglobulin mu-Chains; D037102:Lectins