[Impact, on blood and tissue lipids, of an artificial lipid emulsion combined with essential amino acids and sorbitol, used in humans in exclusive parenteral feeding].
The effects of a complete parenteral feeding of long duration were studied in patients hospitalized in an Intensive Care Unit for an affection requiring this type of alimentation or presenting a state of irreversible prolonged coma. We used the Trive 1000 (EGIC Laboratories) which is a soya oil emulsion combined with essential amino-acides and with Sorbitol. The caloric intake was completed by glucose-solutes mixed with the indispensable vitamins andoligo-elements. Repeated blood-balances, biopsies of the panniculus adiposus and takings of organs (whenever a death occured) were carried out. The after-effects of this type of alimentation were studied in the blood and in the tissues: 1 = On the level of the lipometabolism, the absence of significant modifications in the different categories of lipids and plasmatic lipoproteins shows the quality of the injected fat elimination. On the tissular level, the collecting of alimentary fats is studied from the point of the lipase - lipoprotein activity and the quantitative and qualitive variations of the main classes of lipids. 2 - On the level of the blood biological constants, certain irregularities were noticed, the meaning of which is being discussed.
D000273:Adipose Tissue / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D000601:Amino Acids, Essential / Q000008:administration & dosage* / Q000494:pharmacology; D001095:Arachidonic Acids / Q000378:metabolism; D001777:Blood Coagulation / Q000187:drug effects; D002308:Cardiolipins / Q000378:metabolism; D004655:Emulsions; D005227:Fatty Acids / Q000378:metabolism; D005260:Female; D006400:Hematocrit; D006801:Humans; D050356:Lipid Metabolism; D008055:Lipids / Q000008:administration & dosage* / Q000097:blood / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D010288:Parenteral Nutrition; D010714:Phosphatidylethanolamines / Q000378:metabolism; D013012:Sorbitol / Q000008:administration & dosage* / Q000494:pharmacology; D014280:Triglycerides / Q000378:metabolism
D000601:Amino Acids, Essential; D001095:Arachidonic Acids; D002308:Cardiolipins; D004655:Emulsions; D005227:Fatty Acids; D008055:Lipids; D010714:Phosphatidylethanolamines; D014280:Triglycerides; D013012:Sorbitol
Retentissement sur les lipides, sanguins et tissulaires, d'une émulsion lipidique artificielle, associée à des acides aminés essentiels et à du sorbitol, utilisée chez l'homme, en alimentation parentérale exclusive