Leg phlebography: the incidence, nature and modification of undesirable side effects.
A prospective study was performed to elucidate the side effects of contrast medium phlebography for the diagnosis of deep vein thrombophlebitis (DVTP). The phelbograms were obtained with the patient in a semi-erect position, with an average dose of 125 ml of contrast medium infused continuously over 7-12 min. Renografin 60, or the same agent diluted to three-quarter strength, was used. The major side effects were pain during the study and a symptom complex resembling DVTP starting 12-36 hours after the study. Both were more common with the standard contrast medium (pain: 59.0% vs. 30.0%; delayed reaction: 24.0% vs. 7.5%), although the percentage of positive studies was unchanged (about 35.0%). Side effects were more frequent and severe than previously thought, but their incidence can readily be lowered.
D003287:Contrast Media / Q000009:adverse effects*; D003973:Diatrizoate / Q000009:adverse effects; D003974:Diatrizoate Meglumine / Q000009:adverse effects; D005260:Female; D006801:Humans; D007249:Inflammation / Q000209:etiology; D007866:Leg / Q000098:blood supply*; D008297:Male; D010146:Pain / Q000209:etiology; D010690:Phlebography / Q000009:adverse effects*; D011446:Prospective Studies; D013924:Thrombophlebitis / Q000000981:diagnostic imaging; D013997:Time Factors
D003287:Contrast Media; D003973:Diatrizoate; D003974:Diatrizoate Meglumine