Antigen-induced co-capping of IgM and IgD-like receptors on murine B cells.
Double fluorescence studies indicated that most mature lymphocytes of 11-52-wk-old mice possess both IgM and IgD-like surface immunoglobulins, while spleen cells from neonatal mice possess surface IgM only. These molecules cap independently with class-specific antisera, but co-cap when capping is induced by antigen. It is proposed that the two heavy chains on individual lymphocytes possess similar or identical antigen-combining sites.
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn / Q000276:immunology; D000937:Antigen-Antibody Reactions; D001402:B-Lymphocytes / Q000276:immunology*; D001665:Binding Sites; D001666:Binding Sites, Antibody; D001853:Bone Marrow / Q000276:immunology; D005260:Female; D007072:Immunoglobulin D; D007075:Immunoglobulin M; D007138:Immunoglobulin delta-Chains / Q000032:analysis; D007148:Immunoglobulin mu-Chains / Q000032:analysis; D008198:Lymph Nodes / Q000276:immunology; D008297:Male; D051379:Mice; D010581:Peyer's Patches / Q000276:immunology; D011947:Receptors, Antigen, B-Cell / Q000032:analysis*; D013154:Spleen / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology
D007072:Immunoglobulin D; D007075:Immunoglobulin M; D007138:Immunoglobulin delta-Chains; D007148:Immunoglobulin mu-Chains; D011947:Receptors, Antigen, B-Cell