[The genesis of experimental granulosa cell tumors of the ovaries].
Ovaries and their tumors were investigated in virgin female mice (78 control and 252 experimental) of line A and CC57W (aged-from 1 to 1 1/2 months) in the experiments with intravaginal application of polyurethan, 7,12-dimethylbenz (a) anthracene, 8-oxychinoline, synoestrol. It was demonstrated that only granulosa elements of atresic follicles are involved in the process of blastomogenesis. Theca-tissue showed no appreciable participation in proliferative processes. Totally, pretumor changes were noted in 56 cases, folliculomas or pathological changes morphologically identical to microfolliculomas- in 26 cases.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D002273:Carcinogens; D005260:Female; D006106:Granulosa Cell Tumor / Q000139:chemically induced*; D006589:Hexestrol; D051379:Mice; D008805:Mice, Inbred A; D008815:Mice, Inbred Strains; D010051:Ovarian Neoplasms / Q000139:chemically induced*; D015125:Oxyquinoline; D011140:Polyurethanes
D002273:Carcinogens; D011140:Polyurethanes; D006589:Hexestrol; D015127:9,10-Dimethyl-1,2-benzanthracene; D015125:Oxyquinoline
O geneze éksperimental'nykh granulezokletochnykh opukholeĭ iaichnikov