Correlation in hemodialysis patients and renal allograft recipients between percent T lymphocytes in peripheral blood and in vitro lymphocyte responses to nonspecific mitogenic agents.
Both hemodialysis and renal allograft recipients have a significantly reduced number of total T lymphocytes per microliter of blood. Simultaneous in vitro lymphocyte responsiveness to phytohemagglutinin (PHA) and pokeweed mitogen (PWM) revealed in the normal subjects, a positive correlation (r = +0.427) between percent T lymphocytes and PHA and a negative correlation (r = -0.525) between percent T lymphocytes and PWM. Such trends were not observed in the hemodialysis patients and transplant recipients. Thus, the enumeration of lymphocytes as T cells appears to provide no clear indication of their functional capacity to respond to mitogenic stimulation in these two categories of patients.
D006801:Humans; D007104:Immune Adherence Reaction; D007111:Immunity, Cellular; D007668:Kidney / Q000276:immunology; D007676:Kidney Failure, Chronic / Q000276:immunology; D016030:Kidney Transplantation; D037102:Lectins / Q000494:pharmacology; D007958:Leukocyte Count; D008213:Lymphocyte Activation / Q000187:drug effects; D008934:Mitogens / Q000494:pharmacology*; D006435:Renal Dialysis; D013268:Stimulation, Chemical; D013601:T-Lymphocytes / Q000276:immunology*; D014184:Transplantation, Homologous
D037102:Lectins; D008934:Mitogens