Hydrogen peroxide production by leukocytes in protein-calorie malnutrition.
Hydrogen peroxide (H2O2) production during phagocytosis was studied in polymorphonuclear leukocytes obtained from children suffering from severe protein-calorie malnutrition. Formation of H2O2 was significantly reduced both in the resting condition and during phagocytosis. Improvement in this function of leukocytes was observed following nutritional rehabilitation. Sub-optimal H2O2 production during phagocytosis may be one of the reasons for impaired bactericidal activity of leukocytes seen in children with protein-calorie malnutrition.
D002675:Child, Preschool; D005561:Formates / Q000097:blood; D006801:Humans; D006861:Hydrogen Peroxide / Q000097:blood*; D007223:Infant; D009504:Neutrophils / Q000378:metabolism*; D010587:Phagocytosis; D011502:Protein-Energy Malnutrition / Q000097:blood* / Q000503:physiopathology
D005561:Formates; D006861:Hydrogen Peroxide