title: Intensive and prolonged tetracycline therapy in non-specific urethritis.
abstract: Details are given of a double-blind trial involving 400 cases in which tetracycline 500 mg. four times a day for 7 days was compared with tetracycline 250 mg. four times a day for 14 days and also of the findings in 311 cases treated with Deteclo 300 mg. three times a day for 3 weeks. The treatment in the double-blind trial were equally effective and appeared to be as effective as the long-term Deteclo therapy. When the results of these treatments were compared with those obtained previously with tetracycline 250 mg. four times a day for 4 days and allowance was made for the time at which the latter results have been assessed, it was concluded that neither the treatment used in the double-blind trial nor Deteclo 300 mg. three times a day for 3 weeks offered any advantage over the customary treatment with tetracycline 250 mg, four times a day for 4 days.
mesh_terms: D002751:Chlortetracycline / Q000008:administration & dosage / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003707:Demeclocycline / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D010118:Oxytetracycline / Q000008:administration & dosage / Q000627:therapeutic use; D013752:Tetracycline / Q000008:administration & dosage / Q000627:therapeutic use; D013754:Tetracyclines / Q000008:administration & dosage* / Q000627:therapeutic use; D013997:Time Factors; D014526:Urethritis / Q000188:drug therapy*
chemical_list: D013754:Tetracyclines; D003707:Demeclocycline; D013752:Tetracycline; D002751:Chlortetracycline; D010118:Oxytetracycline