Incorporation of 4,5-3H leucine into the neurons of locus ceruleus and other nerve cells in stressed rats: effect of diazepam.
Incorporation of 4,5-3H leucine into neurons of locus ceruleus, neurons of the terminal principal nucleus of the trigeminal nerve and spinal moto-neurons in stressed rats (S group), animals, stressed after a single injection of diazepam (DS group), and controls (C group) was studied by quantitative autoradiography. Both in the S and DS groups the planimetrically measured neuronal areas were bigger than in the C group of spinal motoneurons and trigeminal neurons. Stress, however, had no effect on the size of neurons in locus ceruleus. No significant differences of grain density among C and S group were found in the three investigated neuronal groups; diazepam pretreatment (DS group), however, increased markedly the grain density in all types of neurons investigated.
D000818:Animals; D001345:Autoradiography; D002552:Cerebral Ventricles / Q000378:metabolism*; D003975:Diazepam / Q000494:pharmacology*; D006801:Humans; D008297:Male; D009046:Motor Neurons / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D009474:Neurons / Q000378:metabolism*; D051381:Rats; D013116:Spinal Cord / Q000378:metabolism; D013315:Stress, Psychological; D014276:Trigeminal Nerve / Q000378:metabolism
D009419:Nerve Tissue Proteins; D003975:Diazepam