5-Aryloxy-6-methoxy-8-aminoquinolines as potential prophylactic antimalarials.
5-(p-Anisyloxy)-6-methoxy-8-(5-isopropylaminopentylamino)quinoline was resynthesized for evaluation in the Plasmodium berghei and monkey prophylactic (Plasmodium cynomolgi) tests. A new primary amine, three secondary amines, and one structurally modified side-chain analog of the 5-aryloxy series were also prepared. None of these compounds showed significant antimalarial or prophylactic activity.
D000634:Aminoquinolines / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000962:Antimalarials; D000882:Haplorhini; D008288:Malaria / Q000517:prevention & control*; D010962:Plasmodium berghei / Q000187:drug effects*
D000634:Aminoquinolines; D000962:Antimalarials