The effect of adrenergic system on glycogen synthetase activity in myocardium and skeletal muscle.
The activity of glycogen synthetase after in vivo stimulation and blockade of adrenergic receptors was determined in myocardium and skeletal muscle. Stimulation of alpha-adrenergic receptor by means of phenylephrine was found to increase the activity of synthetase form I both in the heart and skeletal muscle. Isoprenaline decreases the synthetase form I activity in both muscles under study by stimulation of beta-adrenergic receptor. Adrenaline alone or administered after alpha-adrenergic receptor blockade by phenoxybenzamine acts similarly as isoprenaline. These are data at disposal that stimulation of alpha-adrenergic receptor produces in myocardium and skeletal muscle cells the changes responsible for the increase of anabolic processes in glycogen metabolism.
D000818:Animals; D004347:Drug Interactions; D004837:Epinephrine / Q000494:pharmacology; D006006:Glycogen Synthase / Q000378:metabolism*; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009132:Muscles / Q000201:enzymology*; D009206:Myocardium / Q000201:enzymology*; D009638:Norepinephrine / Q000494:pharmacology; D010643:Phenoxybenzamine / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D051381:Rats; D013566:Sympathomimetics / Q000494:pharmacology*
D013566:Sympathomimetics; D010643:Phenoxybenzamine; D010656:Phenylephrine; D006006:Glycogen Synthase; D007545:Isoproterenol; D009638:Norepinephrine; D004837:Epinephrine