The adjuvant activity of a non-toxic, water-soluble glycopeptide present in large quantities in the culture filtrate of Mycobacterium tuberculosis strain DT.
A water-soluble mycobacterial glycopeptide was obtained in large quantities from the culture supernatant fluid of M. tuberculosis strain DT. This glycopeptide was strongly adjuvant-active when injected, in a water-in-oil emulsion contianing ovalbumin, into guinea-pigs. In addition, it was devoid of cord factor toxicity in mice, polyarthritogenic activity in rats and cavity stimulating activity in rabbit lungs.
D000276:Adjuvants, Immunologic; D000818:Animals; D001168:Arthritis / Q000276:immunology; D003311:Cord Factors / Q000633:toxicity; D003315:Cornea / Q000276:immunology; D006020:Glycopeptides / Q000276:immunology*; D006023:Glycoproteins / Q000633:toxicity; D006168:Guinea Pigs / Q000276:immunology; D006968:Hypersensitivity, Delayed; D007074:Immunoglobulin G / Q000032:analysis; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D010047:Ovalbumin / Q000276:immunology; D011233:Precipitin Tests; D011817:Rabbits; D051381:Rats; D011917:Rats, Inbred Lew; D012882:Skin Tests; D012995:Solubility; D014397:Tuberculosis, Pulmonary / Q000276:immunology
D000276:Adjuvants, Immunologic; D003311:Cord Factors; D006020:Glycopeptides; D006023:Glycoproteins; D007074:Immunoglobulin G; D010047:Ovalbumin