Preferential cytotoxicity of 5-thio-D-glucose against hypoxic tumor cells.
5-Thio-D-glucose effectively killed hypoxic mastocytoma cells of DBA/2J mice, whereas it merely suppressed the growth of oxic cells. This specific toxicity suggested that 5-thio-D-glucose may be a useful adjuvant to radiotherapy by eliminating hypoxic protection.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D002470:Cell Survival / Q000187:drug effects; D005947:Glucose / Q000031:analogs & derivatives* / Q000494:pharmacology; D000860:Hypoxia; D012515:Mast-Cell Sarcoma / Q000188:drug therapy; D051379:Mice; D008811:Mice, Inbred DBA; D010100:Oxygen; D012513:Sarcoma, Experimental / Q000188:drug therapy*; D013438:Sulfhydryl Compounds / Q000494:pharmacology
D000970:Antineoplastic Agents; D013438:Sulfhydryl Compounds; C003002:5-thio-D-glucose; D005947:Glucose; D010100:Oxygen