Mitogenicity of Corynebacterium parvum for mouse lymphocytes.
Corynebacterium parvum, a powerful in vivo immunostimulant, is shown to stimulate lymphocyte proliferation in vitro. C. parvum is mitogenic for B lymphocytes and does not stimulate T cells. The mitogenicity is dependent on the presence of macrophages. C. diphtheriae and another strain of C. parvum, both of which are devoid of adjuvant, RES stimulation, and tumour-inhibiting activities in vivo are nevertheless mitogenic. A lipid-free fraction from C. parvum, which retains in vivo immunostimulatory properties, is not mitogenic. Thus the mitogenic property is not correlated with the in vivo properties of C. parvum.
D000276:Adjuvants, Immunologic; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D002469:Cell Separation; D002478:Cells, Cultured; D003353:Corynebacterium diphtheriae / Q000276:immunology; D037102:Lectins / Q000494:pharmacology; D008213:Lymphocyte Activation; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008938:Mitosis; D011425:Propionibacterium acnes / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D000276:Adjuvants, Immunologic; D037102:Lectins