title: [Therapy of arterial-circulation disorders in the legs. Muscle-ergometric studies under the effects of butalamine hydrochloride in a double-blind trial].
abstract: The extent to which a 10-day-treatment with Butalamine hydrochloride (3 X 2 tablets daily) may increase the muscular capacity in patients suffering from blood flow disorders of the lower limb was studied in a cross-over double-blind-trial. According to Fontaine comparative tests were performed with placebo and the substance in 19 patients suffering from stage II occlusion (either unilateral or bilateral). The muscular capacity in legs with blood flow disorders was found to be significantly improved by the drug compared to the placebo. Except in the case of exercise effect, the muscular capacity of the "intact" extremity however was not found to be significantly improved by the drug. Further specific studies with show whether the walking distance is improved by an increase in muscular capacity.
mesh_terms: D000328:Adult; D000368:Aged; D001157:Arterial Occlusive Diseases / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D005080:Exercise Test; D006801:Humans; D008875:Middle Aged; D009132:Muscles / Q000187:drug effects* / Q000503:physiopathology; D010069:Oxadiazoles / Q000627:therapeutic use*; D005082:Physical Exertion; D010919:Placebos
chemical_list: D010069:Oxadiazoles; D010919:Placebos
vernacular_title: Zur Therapie arterieller Durchblutungsstörungen der unteren Extremitäten. Muskelergometrische Untersuchungen unter dem Einfluss von Butalaminhydrochlorid im Doppelblind-Versuch