title: Osteolytic lesion indicating Pseudomonas sternal osteomyelitis.
abstract: Two cases of osteolytic lesion of the sternum were caused by Pseudomonas aeruginosa. Both were in heroin addicts, and both occurred as a delayed reaction to injury in an automobile accident. Bony curettage and appropriate antibiotic therapy were sufficient for diagnosis and cure. Tobramycin sulfate (3 mg/kg/day), a new aminoglycoside, was successfully used in both instances. Excision of the sternum was not necessary.
mesh_terms: D000063:Accidents, Traffic; D000328:Adult; D006556:Heroin Dependence / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000175:diagnosis* / Q000188:drug therapy; D011552:Pseudomonas Infections / Q000175:diagnosis* / Q000188:drug therapy; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification; D013249:Sternum / Q000293:injuries / Q000473:pathology; D014031:Tobramycin / Q000627:therapeutic use
chemical_list: D014031:Tobramycin