[Individual variations in the frequency of chromosome aberrations following exposure to chemical mutagens. III. Interindividual differences at different stages of the cell cycle].
The object of this investigation was the sensitivity to chemical mutagens of chromosomes of human lymphocytes obtained from different individuals. The distribution of individuals with respect to their sensitivity to fotrin and cytosine-arabinoside was studied. Tests for two characteristics were used, viz. "the percent of aberrant metaphases" and "the number of chrimosome breaks per 100 cells". It is shown by the statistical analysis, that the distribution does not depend on the stage of the cell cycle. The distribution of the individuals tested with respect to their sensitivity to mutagens was shown to be normal. Certain recommendations concerning the planning of experiments and the exposure of the experimental data are given by the authors.
D001388:Aziridines / Q000494:pharmacology*; D001389:Azirines / Q000494:pharmacology*; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects*; D003561:Cytarabine / Q000494:pharmacology; D014644:Genetic Variation; D008938:Mitosis / Q000187:drug effects*; D009025:Morpholines / Q000494:pharmacology; D009153:Mutagens / Q000494:pharmacology*; D013852:Thiotepa / Q000494:pharmacology
D001388:Aziridines; D001389:Azirines; D009025:Morpholines; D009153:Mutagens; D003561:Cytarabine; C007779:fotrin; D013852:Thiotepa
Individual'nye variatsii chastoty khromosomnykh aberratsiĭ pri deĭstvii khimicheskikh mutagenov. Soobshchenie III. Mezhindividual'nye variatsii na raznykh stadiiakh kletochnogo tsikla.