The effect of TRH on the anterior pituitary adenylate-cyclase activity of rat.
Synthetic thyrotropin releasing hormone was found to stimulate rat anterior pituitary adenylate cyclase activity. In the presence of guanosine triphosphate, no further stimulation was recorded; guanosine triphosphate alone also increased the adenylate cyclase activity. Prostaglandin E1 was found to stimulate a basal enzyme activity and this effect was significantly enhanced by guanosine triphosphate. It appears that guanosine triphosphate could be a modulator of adenylate cyclase activity in rat anterior pituitary in response to PGE1 but not to TRH.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D006160:Guanosine Triphosphate / Q000378:metabolism / Q000494:pharmacology; D008297:Male; D010902:Pituitary Gland / Q000187:drug effects*; D010903:Pituitary Gland, Anterior / Q000187:drug effects* / Q000201:enzymology; D011458:Prostaglandins E / Q000494:pharmacology; D051381:Rats; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*
D011458:Prostaglandins E; D013973:Thyrotropin-Releasing Hormone; D006160:Guanosine Triphosphate; D000262:Adenylyl Cyclases