Photochemotherapy for psoriasis with orally administered methoxsalen.
Photochemotherapy denotes a therapeutic approach that is based on the interaction of light and a photoactive drug. This study describes the efficacy of photochemotherapy, using orally administered methoxsalen and long-wave ultraviolet light in 91 patients with severe, generalized psoriasis. Oral administration of methoxsalen was followed by exposure to a high-intensity long-wave ultraviolet light source, emitting a continuous spectrum between 320 and 390 nm (peak, 365 nm) and an energy of 5.6 to 7.5 mw/sq cm at 15 cm. There was complete clearing of 82 patients (90%), a 90% to 100% clearing in seven (8%), and a satisfactory improvement in two (2%). A paired comparison study in 54 patients showed photochemotherapy to be far more effective than ultraviolet light emitted by fluorescent bulbs or a xenon source. Eighty-five percent of the patients receiving outpatient maintenance treatment have remained in remission for periods up to 400 days.
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008134:Long-Term Care; D008730:Methoxsalen / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D010858:Pigmentation / Q000528:radiation effects; D011565:Psoriasis / Q000188:drug therapy / Q000628:therapy*; D012008:Recurrence; D012075:Remission, Spontaneous; D014467:Ultraviolet Therapy / Q000009:adverse effects / Q000379:methods*
D008730:Methoxsalen