Possible peripheral adrenergic and central dopaminergic influences in memory consolidation.
The posttrial i.p. administration of clonidine (0.1 mg/kg) or haloperidol (0.5 mg/kg) to rats trained on a shuttle avoidance paradigm resulted in lower retention of the task in a retest session carried out 7 days later, compared to animals which received posttrial saline injections. The effect of clonidine was antagonized by either phenoxybenzamine (10 mg/kg) or phentolamine (10 mg/kg) i.p., and that of haloperidol was antagonized by 4, but not by 0.5 mg/kg of apomorphine i.p. Neither apomorphine, nor phentolamine or phenoxybenzamine had any effect on their own. The data suggest that memory consolidation of two-way avoidance may be influenced by presumably peripheral adrenergic mechanisms and by presumably central dopaminergic mechanisms.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001362:Avoidance Learning / Q000187:drug effects; D003000:Clonidine / Q000494:pharmacology; D004298:Dopamine / Q000502:physiology*; D005260:Female; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D008568:Memory / Q000502:physiology*; D010643:Phenoxybenzamine / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D051381:Rats; D012153:Retention, Psychology / Q000187:drug effects / Q000502:physiology*; D013564:Sympathetic Nervous System / Q000502:physiology*
D010643:Phenoxybenzamine; D006220:Haloperidol; D003000:Clonidine; D001058:Apomorphine; D004298:Dopamine; D010646:Phentolamine