Somatic mutation as the basis for malignant transformation of BHK cells by chemical carcinogens.
The chemical induction of malignant transformation in BHK cells seems to result from a somatic mutation. Stable transformants, whose frequency is significantly increased by mutagenic carcinogens, can revert to normal and often display temperature-restricted phenotypes indicative of an altered gene product.
D015112:4-Nitroquinoline-1-oxide / Q000494:pharmacology; D000818:Animals; D002273:Carcinogens / Q000494:pharmacology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D006224:Cricetinae; D008770:Methylnitrosourea / Q000494:pharmacology; D009154:Mutation / Q000187:drug effects; D013696:Temperature
D002273:Carcinogens; D015112:4-Nitroquinoline-1-oxide; D008770:Methylnitrosourea