Recruitment and plasmapheresis of donors to provide human antitetanus immunoglobulin.
A method is described whereby about 100 litres of plasma containing 10-50 IU/ml tetanus antitixin was obtained, from which were prepared 5000 X 250 IU doses of human antitetanus immunoglobulin. Of 40 blood donors who received a booster injection of tetanus vaccine BP, 33 were plasmapheresed each week over a 10-12 week period starting three weeks after the injection. Twenty-two of these donors provided 90% of the total plasma, the antitoxin content of which averaged 23.6 IU/ml over the 10-12 week period.
D001782:Blood Donors; D006801:Humans; D005779:Immunodiffusion; D007136:Immunoglobulins / Q000032:analysis; D010956:Plasmapheresis; D013743:Tetanus Antitoxin / Q000032:analysis*; D013745:Tetanus Toxoid
D007136:Immunoglobulins; D013743:Tetanus Antitoxin; D013745:Tetanus Toxoid