Relationship between Intralipid-induced hyperlipemia and pulmonary function.
One unit (500 ml) of 10% Intralipid (an intravenous soy bean oil-egg yolk lecithin preparation) was infused into 20 normal subjects over 4 hr. Serum triglyceride concentration and plasma optic density (at 700 nm) increased to maximal levels of 339 +/- 102 mg/100 ml and 1.14 +/- 0.41, respectively, at the completion of the infusion, and returned to basal levels in most subjects within 4 hr. Pulmonary membrane diffusion was decreased in six subjects at rest and with exercise at 25 and 50% maximum oxygen uptake. Only one subject showed a minor change in PO2 and none showed clinical signs of ischemia. The changes in pulmonary diffusion reverted to basal levels when serum lipids were cleared. Heparin (60 IU/kg) prevented the marked increase in serum lipids and, as a consequence, the changes in pulmonary function. Changes in pulmonary function from Intralipid-induced lipemia are similar to those known to result from diet-induced lipemia. The findings suggest that in the presence of normal vasculature and pulmonary function, Intralipid-induced lipemia should cause no clinical consequences. However, patients with preexisting pulmonary or vascular disease may be at greater risk after Intralipid-induced lipemia.
D000328:Adult; D000818:Animals; D001769:Blood; D002248:Carbon Monoxide; D004530:Egg Yolk; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000209:etiology*; D008055:Lipids / Q000008:administration & dosage*; D008099:Liver / Q000033:anatomy & histology; D008168:Lung / Q000033:anatomy & histology; D009391:Nephelometry and Turbidimetry; D009821:Oils / Q000008:administration & dosage; D010100:Oxygen; D010101:Oxygen Consumption / Q000187:drug effects; D010288:Parenteral Nutrition / Q000009:adverse effects; D010713:Phosphatidylcholines / Q000008:administration & dosage; D011653:Pulmonary Diffusing Capacity / Q000187:drug effects*; D011817:Rabbits; D013025:Glycine max; D014280:Triglycerides / Q000097:blood
D008055:Lipids; D009821:Oils; D010713:Phosphatidylcholines; D014280:Triglycerides; D002248:Carbon Monoxide; D010100:Oxygen