title: Inhibition of allergic reactions by cromoglycate and by a new anti-allergic drug(10-chloro-1,4,6,9-tetrahydro-4,6-dioxopyrido(3,2-g)quinoline-2,8-dicarboxylic acid). II. Activity in primates against aerosolized Ascaris suum antigen.
abstract: Immediate type hypersensitivity to Ascaris antigen in rhesus reactor monkeys was used to assess the pharmacologic profile of Cromolyn Na and a new inhibitor of IgE-medited lung function changes. Cutaneous reactivity to Ascaris correlated poorly with a respiratory response to antigen. Two parameters used to measure lung function, respiratory rate increase and tidal volume decrease, were significantly altered by Cromolyn Na and compound A.
mesh_terms: D000336:Aerosols; D000818:Animals; D000941:Antigens / Q000008:administration & dosage; D001200:Ascaris / Q000276:immunology*; D004205:Cromolyn Sodium / Q000627:therapeutic use*; D005260:Female; D000882:Haplorhini; D006969:Hypersensitivity, Immediate / Q000175:diagnosis; D007442:Intubation, Intratracheal; D008253:Macaca mulatta; D011728:Pyridones / Q000627:therapeutic use*; D011804:Quinolines / Q000627:therapeutic use*; D012129:Respiratory Function Tests; D012130:Respiratory Hypersensitivity / Q000175:diagnosis / Q000188:drug therapy*; D012882:Skin Tests; D013990:Tidal Volume
chemical_list: D000336:Aerosols; D000941:Antigens; D011728:Pyridones; D011804:Quinolines; D004205:Cromolyn Sodium