TRH by slow, continuous infusion: an antidepressant?
A slow, continuous infusion of 1000 mug TRH (thyrotropin releasing hormone) over a period of 4 h had a very faint and diffuse short-lasting beneficial effect on a group of 10 depressive patients. This was assessed in a double blind cross-over trial with placebo. The effect was of no therapeutic value. No difference was found between the depressive patients and a control group of normal subjects in TSH response, T3 resin uptake, T4 or free thyroxine index values as a consequence of the TRH infusion.
D000275:Adjustment Disorders / Q000188:drug therapy; D000328:Adult; D001714:Bipolar Disorder / Q000188:drug therapy; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D003863:Depression / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D013972:Thyrotropin / Q000097:blood; D013973:Thyrotropin-Releasing Hormone / Q000008:administration & dosage*
D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin