title: RNA synthesis and the accumulation of guanine nucleotides during growth shift down in the blue-green alga Anacystis nidulans.
abstract: Shift down of growth rate in the blue-green alga Anacystis nidulans by reduction of the incident light intensity produced a reduction in the rate of stable RNA accumulation which was correlated with increased concentrations of three phosphorylated compounds, two of which were identified as guanosine 5'-diphosphate-3'-diphosphate (ppGpp) and guanosine 5'-triphosphate3'-diphosphate (pppGpp). The step also causes a large but transient increase in the concentration of GTP. Stable RNA fails to accumulate for a considerable length of time after the concentrations of ppGpp and pppGpp have fallen, suggesting the involvement of another mechanism in the control of stable RNA accumulation.
mesh_terms: D000458:Cyanobacteria / Q000254:growth & development / Q000378:metabolism*; D004926:Escherichia coli / Q000378:metabolism; D006150:Guanine Nucleotides / Q000096:biosynthesis / Q000502:physiology*; D006160:Guanosine Triphosphate / Q000096:biosynthesis; D008027:Light; D010710:Phosphates / Q000378:metabolism; D012313:RNA / Q000096:biosynthesis*; D014498:Uracil / Q000378:metabolism
chemical_list: D006150:Guanine Nucleotides; D010710:Phosphates; D014498:Uracil; D012313:RNA; D006160:Guanosine Triphosphate