[The effect of symphathicotropic substances on liver microsomes in vivo and in vitro].
Ephedrine and propranolol shorten hexobarbital sleeping time and increase amidopyrine-N-demethylation activity. Pholedrine only scarcely acts on these parameters, dihydroergotamine is effective. In vitro, ephedrine, pholedrine, propranolol and above all dihydroergotamine proved to be inhibitors of amidopyrine-N-demethylation. Noradrenaline, cAMP and dibutyryli cAMP were ineffective. An influence of the sympathetic nervous system on biotransformation activity cannot be recognized.
D000632:Aminopyrine; D000818:Animals; D004087:Dihydroergotamine / Q000494:pharmacology; D004809:Ephedrine / Q000494:pharmacology; D006591:Hexobarbital; D066298:In Vitro Techniques; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects*; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D013565:Sympatholytics / Q000494:pharmacology*; D013566:Sympathomimetics / Q000494:pharmacology*; D004124:p-Dimethylaminoazobenzene / Q000494:pharmacology
D013565:Sympatholytics; D013566:Sympathomimetics; D000632:Aminopyrine; D004087:Dihydroergotamine; D011433:Propranolol; D004124:p-Dimethylaminoazobenzene; D006591:Hexobarbital; D004809:Ephedrine
Die Wirkung von Sympathikuswirkstoffen auf Lebermikrosomen in vivo und in vitro