Genetics of mouse antibodies. I. Linkage of the dextran response locus, VH-DEX, to allotype.
The antibody response of mice to alpha-1,3 linked dextran is shown to be controlled by a heavy chain variable region gene, VH-DEX. The map distance between this gene and the heavy chain allotype locus is estimated to be 0.3 recombination units.
D000818:Animals; D000906:Antibodies / Q000235:genetics*; D001666:Binding Sites, Antibody / Q000235:genetics*; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D003911:Dextrans / Q000276:immunology*; D008040:Genetic Linkage; D007126:Immunoglobulin Allotypes; D007143:Immunoglobulin Heavy Chains; D007135:Immunoglobulin Variable Region / Q000235:genetics*; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D011995:Recombination, Genetic
D000906:Antibodies; D003911:Dextrans; D007126:Immunoglobulin Allotypes; D007143:Immunoglobulin Heavy Chains; D007135:Immunoglobulin Variable Region