title: Studies on plasma corticosteroids in the rhesus monkey (Macaca mulatta).
abstract: The physiological regulation of the plasma corticosteroid concentration, measured by competitive protein-binding, was studied in female rhesus monkeys (M. mulatta) sedated with phencyclidine hydrochloride. Morning basal levels of plasma corticosteroids were found to be in the range 8-0-25-2 mug/100 ml, which is lower than that previously reported in this species. A circadian rhythm in plasma cortisol concentration was demonstrated. Prolonged sedation with phencyclidine was associated with a gradual increase in the plasma cortisol concentration. Synthetic alpha1-24 adrenocorticotrophic hormone given intravenously caused a rapid rise in plasma cortisol, the minimum effective dose was between 1 and 10 ng/kg body weight and the response was maximal after 1000 ng/kg. The administration of lysine-vasopressin and the induction of hypoglycaemia by insulin were both followed by an increase in the plasma corticosteroid concentration. Metyrapone caused a decline in plasma 11-hydroxycorticosteroids and a concomitant increase in total corticosteroids measured by competitive protein-binding. It is concluded that the hypothalamic-pituitary-adrenal system in the rhesus monkey functions in a manner which is qualitatively and quantitatively similar to that of man.
mesh_terms: D015062:11-Hydroxycorticosteroids / Q000097:blood; D000305:Adrenal Cortex Hormones / Q000097:blood*; D000758:Anesthesia; D000818:Animals; D001786:Blood Glucose; D002940:Circadian Rhythm; D003366:Cosyntropin / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D013006:Growth Hormone / Q000097:blood; D000882:Haplorhini; D006854:Hydrocortisone / Q000097:blood; D007328:Insulin / Q000494:pharmacology; D008236:Lypressin / Q000494:pharmacology; D008251:Macaca / Q000097:blood*; D008253:Macaca mulatta / Q000097:blood*; D008797:Metyrapone / Q000494:pharmacology; D010622:Phencyclidine
chemical_list: D015062:11-Hydroxycorticosteroids; D000305:Adrenal Cortex Hormones; D001786:Blood Glucose; D007328:Insulin; D003366:Cosyntropin; D008236:Lypressin; D013006:Growth Hormone; D010622:Phencyclidine; D006854:Hydrocortisone; D008797:Metyrapone