Combined chemotherapy and surgery in breast cancer: a review.
The current results of trials testing combined surgery and chemotherapy in patients with breast cancer is reviewed. Information concerning eight trials utilizing nine single-agent regimens was obtained. The results at this time are conflicting. There appear to be differences among the regimens utilized in the various patient subsets. Some of the possible reasons for the observed differences, and their implications for future studies, are discussed.
D001943:Breast Neoplasms / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D008207:Lymphatic Metastasis; D008466:Mechlorethamine / Q000627:therapeutic use; D008937:Mitomycins / Q000627:therapeutic use*; D013852:Thiotepa / Q000627:therapeutic use
D008937:Mitomycins; D008466:Mechlorethamine; D003520:Cyclophosphamide; D013852:Thiotepa; D005472:Fluorouracil