title: [Comparative determination of cellular reactivity during infection with influenza virus A (H3N2)].
abstract: Among 28 strains of influenza A (H3N2) virus isolated from human patients 3 strains were found to be capable of replication in continuous monkey kidney cell cultures. When cells of different origins (PPO, chick embryo chorioallantio membrane, human nasal mucosa) were infected with the virus or when PPO were infected with allantoic or cultural virus strains, the pathological changes were of the same type. No specific inclusions were found in the cells. Adaptation of the virus to PPO cells resulted in inhibition of its hemagglutinating, neuraminidase and interferon-inducing activity and in decrease of thermostability, but the infectious and antgenic properties were retained unchanged.
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism; D000482:Allantois; D000818:Animals; D002642:Chick Embryo; D002823:Chorion; D046508:Culture Techniques; D003588:Cytopathogenic Effect, Viral; D000882:Haplorhini; D006801:Humans; D053122:Influenza A Virus, H3N2 Subtype; D009980:Influenza A virus; D007251:Influenza, Human / Q000201:enzymology / Q000382:microbiology* / Q000517:prevention & control; D007668:Kidney; D009297:Nasal Mucosa; D013385:Succinate Dehydrogenase / Q000378:metabolism; D014611:Vaccination; D014779:Virus Replication
chemical_list: D013385:Succinate Dehydrogenase; D000135:Acid Phosphatase
vernacular_title: Sravnitel'noe opredelenie kletochnoĭ reaktivnosti pri infektsii virusom grippa A (G3N2)