[Test with trinitrine. Clinical evaluation of the beta anti-adrenergic effect of acebutolol in arterial hypertension].
The beta-adrenergic stimulation test with nitroglycerin, described by Fitzgerald, was used to monitor antihypertensive treatment with the beta-blocker acebutolol in 30 hypertensive patients. The nitroglycerin-induced tachycardia was reduced by acebutolol and this allowed the degree of beta-blockage to be estimated. It would also be possible, by tests performed before treatment, to select hypotensive patients who could be highly responsive to beta-adrenergic blockers, for whom there are the best prospects of success.
D000070:Acebutolol / Q000494:pharmacology / Q000627:therapeutic use*; D000328:Adult; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D005996:Nitroglycerin / Q000037:antagonists & inhibitors; D013610:Tachycardia / Q000503:physiopathology
D000070:Acebutolol; D005996:Nitroglycerin
Le test à la trinitrine. Evaluation clinique de l'effet antiadrénergique bêta de l'acébutolol dans l'hypertension artérielle