Mastocytosis: unusual manifestation; clinical and radiologic changes.
Two patients with mast cell disease presented with unusual features. In one the absence of skin lesions made the diagnositic problem a challenging one. Certain of the laboratory findings, especially those related to the serum cholesterol concentration and platelet function tests, were particularyl interesting. Chemotherapy induced partial remission. The second patient had a long, relatively benign course complicated by two episodes of herpes zoster, the last being associated with the Landry-Guillain-Barre syndrome. In both patients the skeletal abnormalities were radiologically similar. When these are present they should be considereed sufficiently characteristic to indicate strongly a diagnosis of mastocytosis.
D000368:Aged; D000818:Animals; D001842:Bone and Bones / Q000000981:diagnostic imaging; D006801:Humans; D008407:Mast Cells / Q000473:pathology; D010006:Osteoblasts; D010014:Osteolysis / Q000000981:diagnostic imaging; D011241:Prednisone / Q000627:therapeutic use; D011817:Rabbits; D011859:Radiography; D012272:Ribs / Q000000981:diagnostic imaging; D013852:Thiotepa / Q000627:therapeutic use; D014582:Urticaria Pigmentosa / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D014750:Vincristine / Q000627:therapeutic use
D014750:Vincristine; D013852:Thiotepa; D011241:Prednisone