title: Adamantanamine derivatives. Antimicrobial activities of certain Mannich bases.
abstract: A series of Mannich condensation products containing the beta-(1-adamantylamino)propiophenone skeleton (type I) and the o-(1-adamantylaminomethyl)phenol skeleton (type II) was synthesized and tested for antimicrobial activity against certain bacteria and fungi by the agar diffusion and tube dilution methods. Type I compounds were more active than type II compounds and had a broad-spectrum effect on certain gram-negative and gram-positive bacteria, acid-fast bacteria, a yeast, and a mold.
mesh_terms: D000547:Amantadine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001234:Aspergillus niger / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009161:Mycobacterium / Q000187:drug effects; D009168:Mycobacterium phlei / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000547:Amantadine