Comparative study of the effects of clonidine and 1,4-dihydrazinophthalazine on catecholamines in essential arterial hypertension (EAH).
The effects of clonidine and of 1,4-dihydrazinophthalazine (DHZPH) on some groups of subjects suffering from EAH were comparatively studied. In the group who received clonidine the values of the total catecholamines (CA) increased through the noradrenaline fraction (NA). The adrenaline (A) fraction remaining at quasi-equal values with the initial ones, a significantly statistic decrease of the adrenaline percentage (A%) from CA occurred. In the cerebrospinal fluid (CSF) a CA decrease was noticed; interesting both fractions but first of all A and leading to the significantly statistic decrease of A%. Therefore, both in blood and in CSF, the therapy with clonidine diminished the values of A% to the proportions found in normal subjects. In the group receiving DHZPH the CA decrease in blood was produced by the decrease of the A absolute values. Consequently, an A% statistically significant decrease was noted. In the CSF the same CA decrease was registered, but more stressed, also due to the decrease of the A fraction. Therefore, the therapy with DHZPH also induced a decrease of the values of A% down to those of normal subjects. The EAH treatment both with clonidine and with DHZPH seems to intervene in mechanisms regulating the tensional values in which the catecholamines are involved.
D002395:Catecholamines / Q000378:metabolism*; D003000:Clonidine / Q000627:therapeutic use*; D004078:Dihydralazine / Q000627:therapeutic use*; D006801:Humans; D006830:Hydralazine / Q000031:analogs & derivatives*; D006973:Hypertension / Q000188:drug therapy* / Q000378:metabolism
D002395:Catecholamines; D006830:Hydralazine; D003000:Clonidine; D004078:Dihydralazine