title: Lipoprotein and lecithin: cholesterol acyltransferase changes in galactosamine-induced rat liver injury.
abstract: Abnormal lipoproteins and drcreased lecithin: cholesterol acyltransferase activity are found in rat plasma following intraperitoneal injection of D-galactosamine. The changes observed, including absence of alpha-lipoprotein and the presence of lipoproteins rich in phospholipid and unesterified cholesterol but deficient in cholesteryl esters, are remarkably similar to changes found in human pathologic states of lecithin: cholesterol acyltransferase deficiency. When examined by electron microscopy, all of the major lipoprotein classes isolated by ultracentrifugation showed morphological abnormalities including the formation of rouleaus consisting of disk-shaped particles.
mesh_terms: D000217:Acyltransferases / Q000172:deficiency*; D000818:Animals; D001059:Apoproteins / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury; D002788:Cholesterol Esters / Q000097:blood; D004195:Disease Models, Animal; D005260:Female; D005688:Galactosamine; D007863:Lecithin Cholesterol Acyltransferase Deficiency; D008052:Lipid Metabolism, Inborn Errors; D008074:Lipoproteins / Q000097:blood; D008107:Liver Diseases / Q000201:enzymology; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000097:blood; D051381:Rats
chemical_list: D001059:Apoproteins; D002788:Cholesterol Esters; D008074:Lipoproteins; D005688:Galactosamine; D000217:Acyltransferases; D007862:Phosphatidylcholine-Sterol O-Acyltransferase