[Polyneuropathy in Waldenström's disease].
The clinical course and biopsy and autopsy findings in a patient with asymmetrical polyneuropathy in Waldenström's disease are reported. Under steroid therapy the patient developed mild diabetes mellitus. In the light of the course of the disease, a causal relationship between the hematologic disease and the peripheral neuropathy is assumed. Although a peripheral nerve could not be examined on autopsy, strong lymphocytic infiltration in the autonomic nerves seems to point to a similar pathogenetic mechanism in the development of polyneuropathy. The other possible causal factors are discussed with reference to the small number of reports in the literature.
D001341:Autonomic Nervous System / Q000473:pathology; D006801:Humans; D006987:Hypesthesia / Q000209:etiology; D007075:Immunoglobulin M; D008214:Lymphocytes; D008297:Male; D008558:Melphalan / Q000627:therapeutic use; D008875:Middle Aged; D009206:Myocardium / Q000166:cytology; D009461:Neurologic Manifestations; D010243:Paralysis / Q000209:etiology; D011654:Pulmonary Edema / Q000209:etiology; D008258:Waldenstrom Macroglobulinemia / Q000150:complications* / Q000188:drug therapy
D007075:Immunoglobulin M; D008558:Melphalan
Polyneuropathie bei Morbus Waldenström