Auto-immune disease.
Auto-immune disease may result from the interaction of the genetic load of the individual, modification of self-tissue antigens by environmental agents such as virus or drugs and abnormalities of the immunological system itself such as the loss of controlling or suppressor T cells with age. In the majority of people the outcome is tolerance, maintenance of normal tissue architecture and function. In the unfortunate few the outcome is auto-immune disease, that is, failure to recognize "self".
D000818:Animals; D000937:Antigen-Antibody Reactions; D001327:Autoimmune Diseases / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D005620:Freund's Adjuvant; D006168:Guinea Pigs; D000882:Haplorhini; D006241:Haptens; D006801:Humans; D007108:Immune Tolerance; D007111:Immunity, Cellular; D007153:Immunologic Deficiency Syndromes / Q000276:immunology; D051379:Mice; D051381:Rats; D013601:T-Lymphocytes / Q000276:immunology; D014780:Viruses / Q000276:immunology
D006241:Haptens; D005620:Freund's Adjuvant