Expression of an immunoglobulin VH gene in natural anti-hapten antibodies.
Nonimmune sera of CBA and C57BL/6 mice had similar anti-(4-hydroxy-3-nitrophenyl)acetyl (NP) titers, but the fine specificities (relative affinities for cross-reactive haptens (4-hydroxy-5-iodo-3-nitrophenyl)acetyl (NIP) and (4-hydroxy-3,5-dinitrophenyl)acetyl (NNP)) were very different. Natural anti-NP antibodies of the C57BL/6 mice resembled immune anti-NP antibodies in being heteroclitic without exception, while both normal and immune anti-NP of the CBA mice were nonheteroclitic. Breeding studies suggested that the C57BL/6 trait of the natural antibodies was controlled by the same VH gene as the C57BL/6 trait of immune anti-NP antibodies.
D000818:Animals; D000906:Antibodies / Q000032:analysis*; D000918:Antibody Specificity; D001435:Bacteriophages / Q000276:immunology; D005796:Genes; D006241:Haptens; D006824:Hybridization, Genetic; D007143:Immunoglobulin Heavy Chains / Q000096:biosynthesis; D051379:Mice; D008810:Mice, Inbred C57BL / Q000276:immunology; D008808:Mice, Inbred CBA / Q000276:immunology; D009578:Nitrobenzenes / Q000276:immunology*
D000906:Antibodies; D006241:Haptens; D007143:Immunoglobulin Heavy Chains; D009578:Nitrobenzenes