[Plasma level of complement fractions C3 and C4 in children with glomerular nephropathies. Correlations with morphological and immunopathological studies of renal biopsies].
The measurement of the plasmatic level of C3 may easily be included in the record of all glomerular nephropathies. Its decrease is an important argument for the diagnosis of post-infectious acute glomerulonephritis, or renal involvement in sepsis supervening to a ventriculo-atrial diversion. Variations of C3 level are of major importance in the management of the nephropathies in systemic lupus. Besides these special etiological circumstances, a persisting low level of C3 most often cooresponds to a membrano-proliferative glomerulonephritis especially of the type characterized by intra-membranous dense deposits.
D000293:Adolescent; D000936:Antigen-Antibody Complex; D001485:Basement Membrane / Q000648:ultrastructure; D001706:Biopsy; D002196:Capillaries / Q000648:ultrastructure; D002648:Child; D002675:Child, Preschool; D003176:Complement C3 / Q000032:analysis*; D003181:Complement C4 / Q000032:analysis*; D003165:Complement System Proteins / Q000032:analysis*; D005455:Fluorescent Antibody Technique; D005921:Glomerulonephritis / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D006801:Humans; D011695:IgA Vasculitis / Q000276:immunology; D005779:Immunodiffusion; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007678:Kidney Glomerulus / Q000276:immunology / Q000648:ultrastructure; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D009404:Nephrotic Syndrome / Q000276:immunology
D000936:Antigen-Antibody Complex; D003176:Complement C3; D003181:Complement C4; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D003165:Complement System Proteins
Taux plasmatique des fractions C3 et C4 du complément dans les néphropathies glomérulaires de l'enfant. Corrélations avec l'étude morphologjque et immuno-pathologique des biopsies rénales