Aspirin stabilization of the blood-aqueous barrier in the human eye.
After anterior chamber paracentesis, patients responded with an effusion of protein into the anterior chamber. Pretreatment with aspirin significantly decreased this trauma-induced, probably prostaglandin-mediated, disruption of the blood-aqueous barrier. Protein levels in aqueous humor of human eyes were measured in samples taken initially and five minutes after anterior chamber tap. The protein rise of 53% in five minutes in control patients was limited to 7% in patients pretreated with systemically administered aspirin. Prostaglandin mechanisms may be important in human ocular trauma and prostaglandin synthetase inhibitors may control the reaction to surgical trauma.
D001082:Aqueous Humor / Q000032:analysis / Q000187:drug effects*; D001241:Aspirin / Q000494:pharmacology*; D001692:Biological Transport / Q000187:drug effects; D001769:Blood / Q000187:drug effects*; D002387:Cataract Extraction; D016039:Corneal Transplantation; D005136:Eye Proteins / Q000032:analysis*; D006801:Humans; D011448:Prostaglandin Antagonists / Q000494:pharmacology; D011451:Prostaglandin-Endoperoxide Synthases / Q000494:pharmacology; D011453:Prostaglandins / Q000494:pharmacology; D013997:Time Factors; D014184:Transplantation, Homologous
D005136:Eye Proteins; D011448:Prostaglandin Antagonists; D011453:Prostaglandins; D011451:Prostaglandin-Endoperoxide Synthases; D001241:Aspirin