title: Preparation of Rocky Mountain spotted fever vaccine suitable for human immunization.
abstract: Rocky Mountain spotted fever vaccine was produced from rickettsiae grown in chicken embryo cells in roller bottle cultures. The rickettsiae were concentrated and purified by passage through a sucrose gradient and inactivated with formalin. This vaccine satisfactorily passed preinactivation and final container testing and is believed to be superior to the presently available yolk sac vaccine.
mesh_terms: D000818:Animals; D004353:Drug Evaluation, Preclinical; D005557:Formaldehyde / Q000494:pharmacology; D006168:Guinea Pigs; D006801:Humans; D007114:Immunization; D007120:Immunochemistry; D012284:Rickettsia rickettsii / Q000187:drug effects / Q000276:immunology*; D012290:Rickettsial Vaccines; D012373:Rocky Mountain Spotted Fever / Q000517:prevention & control*; D014612:Vaccines; D014613:Vaccines, Attenuated
chemical_list: D012290:Rickettsial Vaccines; D014612:Vaccines; D014613:Vaccines, Attenuated; D005557:Formaldehyde