title: [Hypokalemic quadriplegia revealing Fanconi syndrome and myeloma].
abstract: The authors report a case of multiple myeloma presenting in an unusual fashion as a hypokalaemic quadriparesis secondary to a renal proximal tubulopathy. The tubular functional disturbance appeared to be related to the presence of kappa-type light chains. Electron microscopical study demonstrated in the cells of the concoluted tubules abnormalities which apparently constitute the anatomical substratum of this abnormality. Study of tubular function revealed glycosuria, proximal type tubular acidosis and altered reabsorption of phophorus and uric acid.
mesh_terms: D000141:Acidosis, Renal Tubular / Q000209:etiology; D001536:Bence Jones Protein; D006801:Humans; D007008:Hypokalemia / Q000150:complications*; D007145:Immunoglobulin kappa-Chains; D007687:Kidney Tubules, Proximal / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000473:pathology; D011188:Potassium / Q000652:urine; D011782:Quadriplegia / Q000209:etiology*
chemical_list: D007145:Immunoglobulin kappa-Chains; D001536:Bence Jones Protein; D011188:Potassium
vernacular_title: Quadriparésie hypokaliémique révélatric d'un syndrome de Fanconi et d'un myélome