title: [Hypoglycemic complications of oral drug therapy of diabetes mellitus. 21 cases].
abstract: The authors present 21 cases of severe hypoglycaemic side effects in diabetics treated with oral sulphonylurea drugs, including two deaths. The medications involved the most frequently were glibenclamide followed by glybutamide and glicalzide. Such side effects often occur early and are unrelated to dose. The classical predisposing factors were noted : old age, renal insufficiency, hepato-cellular insufficiency, drug associations -- in particular oral anticoagulants and salicylates. The indications for such drugs in the treatment of diabetes are discussed. Their use seems doubly illogical in the case of late onset obesity diabetes since the latter is accompanied by cardiovascular complications. It is dangerous in the elderly, particularly sensitive to the risks of hypoglycaemia and in who the diagnosis of "diabetes" is too often made on inadequate grounds.
mesh_terms: D000367:Age Factors; D000368:Aged; D003920:Diabetes Mellitus / Q000188:drug therapy; D003926:Diabetic Coma; D004347:Drug Interactions; D005260:Female; D005907:Gliclazide / Q000009:adverse effects; D005905:Glyburide / Q000009:adverse effects; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced*; D007004:Hypoglycemic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D007676:Kidney Failure, Chronic / Q000150:complications; D008107:Liver Diseases / Q000150:complications; D008297:Male; D008875:Middle Aged; D009461:Neurologic Manifestations; D013449:Sulfonamides / Q000009:adverse effects
chemical_list: D007004:Hypoglycemic Agents; D013449:Sulfonamides; D005907:Gliclazide; D005905:Glyburide
vernacular_title: Les accidents hypoglycémiques des thérapeutiques orales du diabète. 21 cas