title: Differential ability of colonial types of Neisseria gonorrhoeae to produce infection cutaneous perforated plastic chambers in guinea-pigs and rabbits.
abstract: Perforated plastic chambers implanted subcutaneously in guinea-pigs and rabbits became encapsulated and filled with sterile transudate. When these chambers in guinea-pigs were inoculated with various strans of Neisseria gonorrhoeae, persistent infections were achieved without the use of anti-inflammation agents and in the presence of a substantial predominantly polymorphonuclear inflammatory response. Two strains with small colonies similar to types 1 and 2, and one strain with large colonies similar to type 4 of Kellogg et al. (1963 and 1968), showed differences in infectivity comparable with those that might be expected in man, and passage through guinea-pig chambers increased this infectivity. Rabbit chambers could not be infected without the use of an anti-inflammation drug (betamethasone), and differences in infectivity between strains were not as clear cut. The growth of N. gonorrhoeae in chambers in the guinea-pig provides a convenient model system for studying some aspects of the pathogenicity of this organism.
mesh_terms: D000818:Animals; D001431:Bacteriological Techniques; D001623:Betamethasone / Q000494:pharmacology; D004912:Erythrocytes / Q000166:cytology; D005122:Exudates and Transudates / Q000166:cytology / Q000382:microbiology*; D006069:Gonorrhea / Q000382:microbiology; D006168:Guinea Pigs; D007249:Inflammation; D007962:Leukocytes / Q000166:cytology; D008214:Lymphocytes / Q000166:cytology; D008954:Models, Biological; D009344:Neisseria gonorrhoeae / Q000254:growth & development / Q000472:pathogenicity*; D010969:Plastics; D011817:Rabbits; D013045:Species Specificity
chemical_list: D010969:Plastics; D001623:Betamethasone