X-linked B-lymphocyte immune defect in CBA/HN mice. I. Studies of the function and composition of spleen cells.
A study of the composition and functional properties of spleen cells from the immune deficient CBA/HN mice and their F1 progeny is reported. While abnormalities were seen in both the numbers and function of thymus-independent (B) lymphocytes, all studies involving thymus-dependent (T) lymphocytes were normal. The X-linked nature of the immune defect in these mice was therefore attributed to abnormal or absent B lymphocytes. The possible nature of this defect and the similarity of the immune defect in these mice to certain human X-linked immunodeficiency diseases are discussed.
D000818:Animals; D000937:Antigen-Antibody Reactions; D001345:Autoradiography; D001402:B-Lymphocytes / Q000276:immunology*; D003165:Complement System Proteins; D003208:Concanavalin A; D003433:Crosses, Genetic; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D005455:Fluorescent Antibody Technique; D006084:Graft Rejection; D007106:Immune Sera; D007145:Immunoglobulin kappa-Chains; D007457:Iodine Radioisotopes; D037102:Lectins; D008070:Lipopolysaccharides; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011070:Poly I-C; D011817:Rabbits / Q000276:immunology; D012729:Sex Chromosome Aberrations; D012730:Sex Chromosomes; D016038:Skin Transplantation; D013154:Spleen / Q000166:cytology* / Q000276:immunology / Q000378:metabolism; D013936:Thymidine / Q000378:metabolism; D014184:Transplantation, Homologous; D014316:Tritium
D007106:Immune Sera; D007145:Immunoglobulin kappa-Chains; D007457:Iodine Radioisotopes; D037102:Lectins; D008070:Lipopolysaccharides; D014316:Tritium; D003208:Concanavalin A; D003165:Complement System Proteins; D011070:Poly I-C; D013936:Thymidine