Myocardial renin-angiotensin extraction in man.
Renin activity, renin substrate, and angiotensin II concentration were measured in the aortic and coronary sinus blood of 14 patients. There was a significant gradient for angiotensin II only. The gradient was diminished in areas of ischaemic myocardium. The study suggests that angiotensin II is partially bound, extracted, or destroyed in the coronary circulation of man.
D000328:Adult; D000804:Angiotensin II / Q000097:blood*; D001011:Aorta; D003327:Coronary Disease / Q000097:blood; D003331:Coronary Vessels; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D012083:Renin / Q000097:blood*
D000804:Angiotensin II; D012083:Renin