[Polyacrylic bone cement with added erythromycin and colistin. In vitro studies on bacteriologic activity and diffusion properties].
Erythromycin and colistin are not antagonists and have the property of inhibiting the growth of a large number of aerobic and anaerobic organisms. When they were worked into Chirurgischen Knochenzement Simplex P Radiopaque, the growth of 98% of all anaerobic and aerobic test organisms was inhibited. Separately conducted investigations have shown that each antibiotic can diffuse out of polymerized cement and that the concentration of each antibiotic is far above the minimal inhibitory concentration (MIC) of 96% of the organisms. Consequently, in our opinion it would be of benefit to test the Chirurgische Knochenzement Simplex P Radiopaque with erythromycin and colistin clinically.
D000179:Acrylates / Q000627:therapeutic use*; D001843:Bone Cements; D003091:Colistin / Q000008:administration & dosage*; D004058:Diffusion; D004338:Drug Combinations; D004917:Erythromycin / Q000008:administration & dosage*; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests
D000179:Acrylates; D001843:Bone Cements; D004338:Drug Combinations; D004917:Erythromycin; D003091:Colistin
Polyacryl-Knochenzement angereichert mit Erythromycin und Colistin