Immunosuppression and temporary skin transplantation in the treatment of massive third degree burns.
A method of burn treatment (immunosuppression and temporary skin transplantation) for patients suffering from massive third degree burns is evaluated. The method is based on the prompt excision of all dead tissue (burn eschar) and immediate closure of the wound by skin grafts. Total wound closure is achieved before bacterial infection or organ failure takes place by carrying out all initial excision and grafting procedures within the first ten days post burn and supplementing the limited amount of autograft with allograft. Continuous wound closure is maintained for up to 50 days through immunosuppression. Both azathioprine and ATG have been used but ATG is preferred. During the period of immunosuppression, allograft is stepwise excised and replaced with autograft donor sites regenerate for recropping. Bacterial complications are minimized by housing the patient in the protected environment of the Bacteria Controlled Nursing Unit. Intensive protein and calorie alimentation are provided, and 0.5% aqueous AgNO3 dressings are used. A swinging febrile illness has been associated with large areas of allograft rejection. Eleven children have been treated and seven have been returned to normal, productive schooling.
D000961:Antilymphocyte Serum / Q000627:therapeutic use; D001379:Azathioprine / Q000627:therapeutic use; D001424:Bacterial Infections / Q000517:prevention & control; D002056:Burns / Q000150:complications / Q000188:drug therapy / Q000401:mortality / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006084:Graft Rejection; D006801:Humans; D007165:Immunosuppression Therapy; D007362:Intensive Care Units; D008297:Male; D010289:Parenteral Nutrition, Total; D010406:Penicillins / Q000627:therapeutic use; D012835:Silver Nitrate / Q000627:therapeutic use; D016038:Skin Transplantation; D013601:T-Lymphocytes / Q000276:immunology; D013997:Time Factors; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous; D014945:Wound Healing; D014946:Wound Infection / Q000517:prevention & control
D000961:Antilymphocyte Serum; D010406:Penicillins; D012835:Silver Nitrate; D001379:Azathioprine