[Barbiturate dependence at the cellular level].
In cultivated astroblasts of hamster, clone NN, increasing concentrations of sodium pentobarbital induce morphological changes in the sense of a cell differentiation. At the same time occurs a progressive dependence on the barbiturate, illustrated by cell degeneration when the effector is eliminated from the medium containing the cultivated cells.
D000818:Animals; D001253:Astrocytes / Q000166:cytology / Q000187:drug effects*; D002478:Cells, Cultured; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008954:Models, Biological; D009457:Neuroglia / Q000187:drug effects*; D010424:Pentobarbital / Q000494:pharmacology*; D019966:Substance-Related Disorders; D013997:Time Factors
D010424:Pentobarbital
La dépendance aux barbituriques à l'échelle cellulaire