[Effect of puromycin, nalidixic acid and cycloheximide on neuromuscular transmission].
The action of puromycin, nalidixic acid and cycloheximid on neuromuscular transmission has been assayed using diaphragm-phrenic nerve preparation from rat. The results demonstrate that all antibiotics used, reversibly blodk neuromuscular transmission. Cycloheximid seems to act presynaptically by inhibiting acetylcholine release from nerve terminal. Puromycin and nalidixic acid act as curare-like agents. They seem to compete with acetylcholine for fixation at the cholinergic receptor.
D000818:Animals; D002118:Calcium / Q000494:pharmacology; D003513:Cycloheximide / Q000494:pharmacology*; D003964:Diaphragm; D004558:Electric Stimulation; D004576:Electromyography; D009119:Muscle Contraction / Q000187:drug effects; D009268:Nalidixic Acid / Q000494:pharmacology*; D009388:Neostigmine / Q000494:pharmacology; D009469:Neuromuscular Junction / Q000187:drug effects*; D010791:Phrenic Nerve / Q000502:physiology; D011691:Puromycin / Q000494:pharmacology*; D051381:Rats
D009388:Neostigmine; D009268:Nalidixic Acid; D011691:Puromycin; D003513:Cycloheximide; D002118:Calcium
Action de la puromycine, de l'acide nalidixique et de la cyclohexmide sur la transmission neuro-musculaire