title: Changes in local cerebral blood flow following profound systemic hypotension.
abstract: The authors studied local cerebral blood flow in monkeys rendered hypotensive by infusion of a ganglionic blocking agent. Application of the 14C-antipyrine method demonstrated that the blood flow: 1) normally varies reproducibly from one structure to another within the brain; 2) appears at its lowest level in all structures during the early minutes of a rapid-onset hypotension; 3) maintains the same general rank order of blood flow rate during hypotension as was present during normotension; and 4) returns to supranormal levels immediately following the rapid restoration of blood pressure. The values for local cerebral blood flow remain close-to-normal in some animals and diminish significantly in others during late recovery from hypotension. The close-to-normal values accompany uncomplicated recoveries while the diminished values appear in those animals which became neurologically depressed. Areas of the brain considered predisposed to hypotensive injury did not exhibit depressions in blood flow rate during hypotension more markedly than did other brain areas. The present results are interpreted as strong evidence against the "border zone" hypothesis.
mesh_terms: D000818:Animals; D001049:Apnea / Q000209:etiology; D001783:Blood Flow Velocity; D001919:Bradycardia / Q000209:etiology; D001921:Brain / Q000098:blood supply / Q000473:pathology; D001927:Brain Diseases / Q000209:etiology; D001929:Brain Edema / Q000209:etiology; D002421:Caudate Nucleus / Q000098:blood supply; D002540:Cerebral Cortex / Q000098:blood supply; D002560:Cerebrovascular Circulation; D002639:Cheyne-Stokes Respiration / Q000209:etiology; D004562:Electrocardiography; D004569:Electroencephalography; D000882:Haplorhini; D006940:Hyperemia / Q000503:physiopathology; D007022:Hypotension / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D008253:Macaca mulatta; D011699:Putamen / Q000098:blood supply