[Rapid and prolonged facilitation of stereotyped motor behavior (verticalization) induced by apomorphine in mice previously submitted to stimulation of dopaminergic receptors].
The climbing behaviour, a stereotyped motor behaviour, is elicited in mice by stimulation of striatal dopamine receptor by low doses of apomorphine. The action of apomorphine is unexpectedly enhanced in animals pretreated with a single dose of this agent (5 mg/kg). This enhancement occurs as early as 2 h following the first administration and persists for at least 3 days. It is also observed after pretreatments with a combination of L-DOPA and dexamphetamine. This effect seems independent from the desensitization of the dopaminergic receptors involved in thermoregulation that we have previously reported.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001519:Behavior / Q000187:drug effects*; D001522:Behavior, Animal / Q000187:drug effects; D003342:Corpus Striatum / Q000187:drug effects; D003913:Dextroamphetamine / Q000494:pharmacology; D004298:Dopamine / Q000502:physiology; D006801:Humans; D007035:Hypothermia / Q000139:chemically induced; D007980:Levodopa / Q000494:pharmacology; D008297:Male; D008680:Metaraminol / Q000494:pharmacology; D051379:Mice; D011984:Sensory Receptor Cells / Q000187:drug effects*; D013239:Stereotyped Behavior / Q000187:drug effects*; D013997:Time Factors
D007980:Levodopa; D008680:Metaraminol; D001058:Apomorphine; D003913:Dextroamphetamine; D004298:Dopamine
Facilitation rapide et prolongée d'un comportement moteur stéréotypé (verticalisation) induit par l'apomorphine, chez des souris ayant préalablement subi une stimulation des récepteurs dopaminergiques