title: Post recognition ion dependent events in mitogen induced lymphocyte proliferation and in cytotoxic effector cell responses.
abstract: This review discusses the increased permeability and enhanced uptake transport of monovalent and divalent cations following mitogen-induced lymphocyte proliferation. The observed Ca2+ uptake is discussed in terms of gated Ca2+ channels. The importance of divalent cations, particularly Ca2+, is discussed in terms of triggering of cytotoxic effector cell responses for three model systems (antibody dependent cytotoxicity, mitogen-induced cytotoxicity and cell mediated cytotoxicity); (85).
mesh_terms: D000906:Antibodies; D001665:Binding Sites; D002118:Calcium / Q000378:metabolism; D002414:Cations, Monovalent; D004492:Edetic Acid; D006801:Humans; D008213:Lymphocyte Activation; D008264:Macrophages / Q000276:immunology; D008934:Mitogens
chemical_list: D000906:Antibodies; D002414:Cations, Monovalent; D008934:Mitogens; D004492:Edetic Acid; D002118:Calcium