Thyroxine inhibition of the proliferative response of the anterior pituitary to thyrotropin releasing hormone in vitro.
TRH increased cell proliferation in organ-cultured rat adenohypophysis. Thyroxine by itself had no effect on adenohypophysial cell proliferation in vitro but inhibited the mitogenic effect of TRH.
D000818:Animals; D008297:Male; D008938:Mitosis / Q000187:drug effects; D009924:Organ Culture Techniques; D010902:Pituitary Gland / Q000187:drug effects*; D010903:Pituitary Gland, Anterior / Q000187:drug effects*; D051381:Rats; D013268:Stimulation, Chemical; D013973:Thyrotropin-Releasing Hormone / Q000037:antagonists & inhibitors*; D013974:Thyroxine / Q000494:pharmacology*
D013973:Thyrotropin-Releasing Hormone; D013974:Thyroxine