Suppression of reaginic antibody (IgE) formation in mice by treatment with anti-mu antiserum.
Neonatally initiated injection of anti-mu antiserum in mice has been shown to suppress the formation of reaginic antibodies in response to infection with the intestinal nematode, Nippostrongylus brasiliensis. This observation supports the hypothesis that IgE-producing cells arise from IgM-bearing precursors.
D000906:Antibodies; D000917:Antibody Formation; D000921:Antibody-Producing Cells / Q000166:cytology / Q000276:immunology; D002454:Cell Differentiation; D007073:Immunoglobulin E / Q000494:pharmacology*; D007143:Immunoglobulin Heavy Chains; D007075:Immunoglobulin M / Q000096:biosynthesis; D007148:Immunoglobulin mu-Chains; D007165:Immunosuppression Therapy; D009559:Nippostrongylus / Q000276:immunology
D000906:Antibodies; D007143:Immunoglobulin Heavy Chains; D007075:Immunoglobulin M; D007148:Immunoglobulin mu-Chains; D007073:Immunoglobulin E