Long-term treatment with ketoprofen in rheumatoid arthritis. A clinical trial with special reference to side-effects.
The tolerance of ketoprofen (2-(3-benzoylphenyl)-propionic acid) was studied in sixteen patients with rheumatoid arthritis during a treatment period up to seven months. The drug was well tolerated with only a few minor side-effects and showed a clear anti-rheumatie effect with a dose of 150 mg/day. This effect may equal that of 4.0 g/day of acetylsalicylic acid or even exceed that, and may be somewhat smaller than that of 600 mg/day of phenylbutazone.
D000700:Analgesics / Q000009:adverse effects / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D001241:Aspirin / Q000627:therapeutic use; D001577:Benzophenones / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003967:Diarrhea / Q000139:chemically induced; D004341:Drug Evaluation; D006261:Headache / Q000139:chemically induced; D006801:Humans; D007660:Ketoprofen / Q000009:adverse effects / Q000627:therapeutic use*; D008134:Long-Term Care; D010653:Phenylbutazone / Q000627:therapeutic use
D000700:Analgesics; D001577:Benzophenones; D007660:Ketoprofen; D010653:Phenylbutazone; D001241:Aspirin