Isolation of a penicillinase producing strain of Neisseria gonorrhoeae.
A gram-negative diplococcus with the qualifications of a gonococcus was isolated from the urethra of a male infected with gonorrhoea in the Far East. The strain proved to be resistant to penicillin G and ampicillin as judged by the paper disc sensitivity test. The resistance was found to be caused by a powerful production of penicillinase which not only acted on penicillin G and ampicillin, but also on methicillin and partly on cephalosporin (cephalotin) by the test employed.
D000667:Ampicillin / Q000494:pharmacology; D006801:Humans; D008297:Male; D009344:Neisseria gonorrhoeae / Q000187:drug effects / Q000201:enzymology* / Q000302:isolation & purification; D010400:Penicillin G / Q000494:pharmacology; D010403:Penicillin Resistance; D010405:Penicillinase / Q000096:biosynthesis*; D014521:Urethra / Q000382:microbiology
D000667:Ampicillin; D010405:Penicillinase; D010400:Penicillin G