title: Chronic eosinophilic leukemia complicated by epidural myeloblastoma.
abstract: Epidural myeloblastoma, which compressed the spinal cord, was the first evidence for chronic granulocytic leukemia, eosinophilic type, Ph chromosome negative. This manifestation was preceded by 3 years follow-up of a patient with persistent eosinophilia of 60% mature eosinophils. The only clues for the diagnosis of leukemia were splenomegaly and high serum vitamin B12, most of which was bound to transcobalamin I. The latter finding presents a useful diagnostic criterium in myeloproliferative disorders.
mesh_terms: D000328:Adult; D004804:Eosinophils; D006801:Humans; D007951:Leukemia, Myeloid / Q000097:blood / Q000150:complications*; D008297:Male; D010954:Plasmacytoma / Q000097:blood / Q000150:complications*; D014155:Transcobalamins / Q000097:blood; D014805:Vitamin B 12 / Q000097:blood
chemical_list: D014155:Transcobalamins; D014805:Vitamin B 12