Limitations of diazoxide reversal of vasospasm.
Diazoxide failed to safely relieve cerebral vasospasm by intracisternal injections in dogs and by intracarotid injections in monkeys despite in vitro documentation of arterial relaxation with this agent. Administration of the drug frequently produced hypotension and, in the presence of vasospasm, was associated with a high mortality rate.
D000818:Animals; D003981:Diazoxide / Q000009:adverse effects / Q000627:therapeutic use*; D004285:Dogs; D000882:Haplorhini; D007022:Hypotension / Q000139:chemically induced; D002546:Ischemic Attack, Transient / Q000188:drug therapy*; D008253:Macaca mulatta
D003981:Diazoxide