[Experimental heart muscle necorses in the rat after administration of 1-noreadrenaline and strophanthin. Light- and electron microscopic studies (author's transl)].
Female rats with a body weight of approximately 200 g regular show necroses of myocardial fibers after subcutaneous injection of 1-Noradrenaline (2.5 mg/kg body weight). After intraperitoneal premedication with Strophanthin k in a therapeutical dosage (2 X 10(-5 g/kg body weight), the increase in number and extent of the necroses is statistically significant. These findings argue against a preventive effect of Strophanthin k and can be explained by the mode of action of catecholamines and glycosides, as both substances, in a like manner, cause an increase in the mobilizable intracellular calcium of the myocardial fiber. Premedication with Strophanthin causes no alteration in the distribution pattern of necroses, nor in the electron-microscope findings in the case of myocardial necroses produced by Noradrenaline.
D000818:Animals; D002118:Calcium / Q000378:metabolism; D009202:Cardiomyopathies / Q000139:chemically induced*; D003529:Cymarine; D004489:Edema, Cardiac / Q000139:chemically induced*; D005260:Female; D006333:Heart Failure / Q000139:chemically induced*; D009206:Myocardium / Q000648:ultrastructure; D009210:Myofibrils / Q000187:drug effects; D009336:Necrosis; D009638:Norepinephrine; D051381:Rats; D012965:Sodium Chloride / Q000494:pharmacology; D013328:Strophanthins
D013328:Strophanthins; D012965:Sodium Chloride; D002118:Calcium; D003529:Cymarine; D009638:Norepinephrine
Experimentelle Herzmuskelnekrosen bei der Ratte nach Gabe von 1-Noradrenalin und Strophanthin.. Licht- und elektronenmikroscopische Untersuchungen