title: Possible contributions of endogenous prostaglandins to the control of blood pressure.
abstract: Prostaglandins are primarily local or tissue hormones which have their effects at or near the site of release and are metabolized before reaching the arterial circulation. A possible exception is prostaglandin A-2, which has been proposed as a circulating hormone; however, there is no evidence that prostaglandin A-2 is biosynthesized in the mammalian kidney or even in extrarenal tissues. The prostaglandin generated and released in the kidney is predominantly E-2. Some blood vessels also synthesize prostaglandins intramurally, where their local release influences vascular tone and reactivity. Endogenous prostaglandin E-2 production contributes to the regulation of blood pressure by (1) opposing the vasoconstrictor and antidiuretic actions of circulating pressor hormones; (2) braking the release of norepinephrine from vasoconstrictor nerves; and (3) participating in the control extracellular fluid volume through its renal hemodynamic actions.
mesh_terms: D000804:Angiotensin II / Q000502:physiology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001920:Bradykinin / Q000502:physiology; D016861:Cyclooxygenase Inhibitors; D006706:Homeostasis; D006940:Hyperemia / Q000503:physiopathology; D006973:Hypertension / Q000503:physiopathology; D007213:Indomethacin / Q000494:pharmacology; D007668:Kidney / Q000098:blood supply / Q000378:metabolism; D009638:Norepinephrine / Q000502:physiology; D011453:Prostaglandins / Q000502:physiology*; D011454:Prostaglandins A / Q000096:biosynthesis; D011460:Prostaglandins F / Q000096:biosynthesis; D011863:Radioimmunoassay; D012039:Regional Blood Flow; D012083:Renin / Q000502:physiology; D013564:Sympathetic Nervous System / Q000502:physiology; D014882:Water-Electrolyte Balance; D014947:Wounds and Injuries / Q000503:physiopathology
chemical_list: D016861:Cyclooxygenase Inhibitors; D011453:Prostaglandins; D011454:Prostaglandins A; D011460:Prostaglandins F; D000804:Angiotensin II; D012083:Renin; D001920:Bradykinin; D009638:Norepinephrine; D007213:Indomethacin