Intranuclear rodlets in an intrathyroid tumor associated with hyperparathyroidism.
A tumor excised from the thyroid gland has been shown by electron microscopy to contain distinctive, intranuclear rodlets. This is the first report of such rodlets in a non-neuronal human tumor. While the parathyroid-like hormonal activity, histopathology, and clinical course are consistent with a parathyroid adenoma, the finding of the rodlets raises the question of origin from a special, neuron-related cell of the parathyroid or thyroid. The unusual cellular granularity and the abundant interstitial fibrillae also suggest an unusual cell of origin. Alternatively, a special metabolic activity may account for the rodlets, or they may have been overlooked in prior studies of adenomas.
D000236:Adenoma / Q000378:metabolism / Q000648:ultrastructure*; D000368:Aged; D000682:Amyloid / Q000378:metabolism; D002277:Carcinoma / Q000378:metabolism / Q000648:ultrastructure; D002467:Cell Nucleus / Q000648:ultrastructure*; D003593:Cytoplasm / Q000648:ultrastructure; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000150:complications*; D010282:Parathyroid Neoplasms / Q000378:metabolism / Q000648:ultrastructure*; D013964:Thyroid Neoplasms / Q000378:metabolism / Q000648:ultrastructure*
D000682:Amyloid