Evidence for Ca2+-activated K+ conductance in cat spinal motoneurons from intracellular EGTA injections.
Ethylene glycol bis-(beta-aminoethyl ether)-N,N'-tetraacetic acid, injected by iontophoresis from triple-barrelled intracellular micropipettes, consistently raised the membrane resistance and depressed the post-spike after hyperpolarization (AHP), but did not slow the falling phase of the action potential. [Ca2+]i-activated K+ channels appear to play a significant role in the genesis of the AHP and in the control of the resting potential, but not in the repolarization phase of the action potential.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002118:Calcium / Q000502:physiology*; D002415:Cats; D004533:Egtazic Acid / Q000494:pharmacology*; D005026:Ethylene Glycols / Q000494:pharmacology*; D008564:Membrane Potentials / Q000187:drug effects; D009046:Motor Neurons / Q000187:drug effects / Q000502:physiology*; D011188:Potassium / Q000502:physiology*; D013131:Spine / Q000502:physiology*; D013997:Time Factors
D005026:Ethylene Glycols; D004533:Egtazic Acid; D011188:Potassium; D002118:Calcium