[Experimental study of the antibacterial action of levomycatin in a 40% solution of hexamethylenetetramine].
Antimicrobial and chemotherapeutic activity of 2 per cent solution of levomycetin in 40 per cent solution of hexamethylentetramine was studied. The preparation was proposed as a new extemporal pharmaceutical form of levomycetin for intravenous administration. It was shown that the bacteriostatic activity of levomycetin in the above pharmaceutical form against microbial cultures sensitive to the antibiotic did not differ from that of levomycetin in the form of an aqueous solution. However, the bactericidal effect of the preparation appeared to be higher as compared to that of the levomycetin aqueous solution, which is explained by the synergistic effect of hexamethylentetramine and levomycetin. The chemotherapeutic effect of the preparation tested on albino mice with experimental infection caused by Coli bacteria was more pronounced than the effect of levomycetin sodium succinate.
D000818:Animals; D001419:Bacteria / Q000187:drug effects*; D002701:Chloramphenicol / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004926:Escherichia coli / Q000187:drug effects; D004927:Escherichia coli Infections / Q000188:drug therapy; D008709:Methenamine / Q000494:pharmacology* / Q000627:therapeutic use; D051379:Mice; D011514:Proteus vulgaris / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D018805:Sepsis / Q000188:drug therapy; D012996:Solutions; D013211:Staphylococcus aureus / Q000187:drug effects; D014867:Water / Q000494:pharmacology
D012996:Solutions; D014867:Water; D002701:Chloramphenicol; D008709:Methenamine
Eksperimental'noe izuchenie protivobakterial'nogo deĭstviia levomitsetina v 40% rastvore geksametilentetramina