Alkalosis and seizure due to a cation-exchange resin and magnesium hydroxide.
A patient with chronic renal failure received sodium polystyrene sulfonate and magnesium hydroxide for the treatment of hyperkalemia. This combination therapy produced a severe metabolic alkalosis which, in the presence of the patient's chronic hypocalcemia, precipitated a grand mal seizure.
D000471:Alkalosis / Q000139:chemically induced*; D002411:Cation Exchange Resins / Q000009:adverse effects* / Q000627:therapeutic use; D003248:Constipation / Q000188:drug therapy; D004359:Drug Therapy, Combination / Q000009:adverse effects; D004830:Epilepsy, Tonic-Clonic / Q000139:chemically induced*; D006801:Humans; D006947:Hyperkalemia / Q000188:drug therapy; D007475:Ion Exchange Resins / Q000009:adverse effects*; D008277:Magnesium Oxide / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged
D002411:Cation Exchange Resins; D007475:Ion Exchange Resins; D008277:Magnesium Oxide