Erythrocyte 2,3-diphosphoglycerate and adenosine-triphosphate in cretins living at high altitude.
A comparison of concentrations of 2,3-diphosphoglycerate (2,3-DPG) and adenosine-triphosphate (ATP) in the red cells of cretins and normal controls living at 3,700 m in the Nepal Himalayas has shown that 2,3-DPG and ATP levels were higher in the cretins. A negative correlation between hemoglobin and 2.3-DPG level was found. Chronic hypoxia appears to have provided the additional stress required to differentiate the significance of thyroid hormone deficiency in producing anemia from its effect on 2,3-DPG levels. If thyroid hormone is in fact one regulator of 2,3-DPG, the anemia of hypothyroidism appears to be more significant. This also suggest that the anemia of hypothyroidism, is at least in part, "pathologic" as opposed to "adaptive".
D000255:Adenosine Triphosphate / Q000097:blood*; D000531:Altitude; D002681:China; D003409:Congenital Hypothyroidism / Q000097:blood*; D003404:Creatinine / Q000097:blood; D004163:Diphosphoglyceric Acids / Q000097:blood*; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D007773:Lactates / Q000097:blood; D008297:Male; D009390:Nepal; D010758:Phosphorus / Q000097:blood; D013974:Thyroxine / Q000097:blood
D004163:Diphosphoglyceric Acids; D007773:Lactates; D010758:Phosphorus; D000255:Adenosine Triphosphate; D003404:Creatinine; D013974:Thyroxine