Innate metabolic differences and mutagen sensitivity of Drosophila melanogaster. I. Radiosensitivity of hyperkinetic mutant.
The sensitivity to gamma-rays of a hyperkinetic mutant (HK1), characterized by high metabolic activity, has been studied and compared with gamma-ray sensitivity of the wild-type Oregon-K. Radiation damage, as measured by the frequency of induced dominant lethals (DL) and sex-linked recessive lethals (SLRL), was more in HK1 as compared with Or-K. The maximal sensitivity differences for these parameters were observed in the first brood. Translocations, on the contrary, were in general fewer in the HK1 compared with Or-K. These results have been interpreted in terms of reduced repair of mutational lesions in the energy-stressed cells of KH1.
D000071877:Checkpoint Kinase 1; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000378:metabolism / Q000528:radiation effects*; D005720:Gamma Rays; D005799:Genes, Dominant / Q000528:radiation effects; D005804:Genes, Lethal / Q000528:radiation effects; D005808:Genes, Recessive / Q000528:radiation effects; D009154:Mutation; D011831:Radiation Genetics; D014178:Translocation, Genetic / Q000528:radiation effects
D029721:Drosophila Proteins; D000071877:Checkpoint Kinase 1; C000605877:grp protein, Drosophila