A modified polyriboinosinic-polyribocytidylic acid complex that induces interferon in primates.
A comlex of polyriboinosinic-polyribocytidylic acid (poly I-poly C) with poly-L-lysine and carboxymethylcellulose has been prepared. This complex is five to 10 times as resistant to hydrolysis by primate serum as the parent poly I-poly C. It has a thermal denaturation temperature about 40 C higher than that of poly I-poly C. The complex induces significant levels of serum interferon in monkeys and chimpanzees under conditions in which poly I-poly C itself induces no interferon.
D000818:Animals; D002266:Carboxymethylcellulose Sodium / Q000494:pharmacology; D005260:Female; D000882:Haplorhini; D006358:Hot Temperature; D006801:Humans; D006868:Hydrolysis; D007372:Interferons / Q000096:biosynthesis* / Q000134:cerebrospinal fluid; D007700:Kinetics; D008251:Macaca / Q000097:blood*; D008253:Macaca mulatta / Q000097:blood*; D051379:Mice; D008970:Molecular Weight; D002679:Pan troglodytes / Q000097:blood*; D011070:Poly I-C / Q000494:pharmacology*; D011107:Polylysine / Q000494:pharmacology
D011107:Polylysine; D007372:Interferons; D002266:Carboxymethylcellulose Sodium; D011070:Poly I-C