[Therapeutic effect of glibenclamide contrasted with other oral antidiabetic agents].
The investigation is realized with 50 diabetics, considered suitable for oral therapy that revealed excellent or satisfactory effect from the Glybenclamide treatment (GCL), applied separately or in combination with butyl biguanide. GCL was established to give far better results than the rest oral antidabetic drugs, permitting a better metabolic syndrome compensation. GCL effect is more manifested than that of tolbutamide. The better therapeutic effect of GCL is obvious as compared with chloropropamide and butyl biguanide, but not so well manifested as with tolbutamide. The therapeutic GCL effect is better in almost all followed up ages, the most advanced incld., which is not cogent for the rest of the oral preparations. Side effects and severe hypoglycemic incidence, reported by other authors, were not observed during the investigation.
D000284:Administration, Oral; D000328:Adult; D001645:Biguanides / Q000627:therapeutic use; D002747:Chlorpropamide / Q000627:therapeutic use; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D003920:Diabetes Mellitus / Q000188:drug therapy; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D005905:Glyburide / Q000627:therapeutic use*; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D014044:Tolbutamide / Q000627:therapeutic use
D001645:Biguanides; D007004:Hypoglycemic Agents; D014044:Tolbutamide; D005905:Glyburide; D002747:Chlorpropamide
Lecheben efekt na glibenklamida, supostaven s drugi oralni protivodiabetni sredstva