[Comparative study in both sexes of the carcinogenic activity of NN-dimethyl-p-(6 benzothiazolylazo) aniline (BT 6) in the Wistar rat].
The carcinogenic action of NN-Dimethyl-p-6 benzothialylazo aniline (BT6) was studied in male and female Wistar rats. The formula of this chemical closely resembling DAB (Butter yellow) has a certain number of special characteristics in the field of liver carcinogenesis. Firstly, all the lobes of the liver are effected simultaneously and with the same degree of severity. Secondly, the males and females are equally affected vis a vis this carcinogen. Particular attention was paid to interval lesions showing which of these phenomena are due to a deficiency regime and which to the effect of BT6. It is noteworthy that the chemical stress is manifested differently in the two sexes. Nevertheless, the time of appearance of the primary carcinoma is the same, that is to say at 120 days in both sexes. The question arises of the importance of interval phenomena in the causation of carcinogenesis by BT6.
D000818:Animals; D005260:Female; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D051381:Rats; D012737:Sex Factors; D013844:Thiazoles; D004124:p-Dimethylaminoazobenzene / Q000031:analogs & derivatives*
D013844:Thiazoles; D004124:p-Dimethylaminoazobenzene
Etude comparative dans les deux sexes du pouvoir cancérogène du NN-dimethyl-p-(6 benzothiazolylazo) aniline (BT 6) -chez le rat Wistar