[Antitumoral immunity induced by the administration of homologous and isologous tumoral cells treated by moderate heating].
Treatment of tumour cells with heat ranging between 46 and 52 degrees C attenuates strongly their virulence and renders the tumour cells immunogenic to the host. By repeated administration of heat treated tumour cells suspended in Freund's complete adjuvant, the animals acquire a state of immunity which makes them tolerant to tumour inocula 100% lethal in the controls. The immunity so conferred is cell-mediated and can be adoptively transferred to isogenic recipients with donor peritoneal exudate and, to a lesser degree, splenic cells.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000276:immunology; D005620:Freund's Adjuvant; D006358:Hot Temperature; D007112:Immunity, Maternally-Acquired; D007114:Immunization; D007271:Injections, Intradermal; D008223:Lymphoma / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000276:immunology*; D012513:Sarcoma, Experimental / Q000276:immunology; D014184:Transplantation, Homologous; D014185:Transplantation, Isogeneic
D005620:Freund's Adjuvant
Immunité antitumorale induite par l'administration de cellules tumorales homologues et isologues traitées par un chauffage ménagé