title: [Metabolic effects of parenteral administration of a combined carbohydrate solution (glucose, fructose, xylitol 2:2:1) (author's transl)].
abstract: A combined carbohydrate in fusate (glucose, fructose, and xylitol in the ratio of 2:2:1) was administered to eight healthy adults at the rate of 0.5 g.kg-1.h-1 for 12 hours. The solution also contained 80 mmol sodium, 30 mmol potassium, 2.5 mmol magnesium, 2.8 mmol phosphate and 110 mmol chloride per litre. Glucose and fructose were almost completely metabolised. The percentage loss of xylitol was very low (8.9% of the administered dose). There was a slight insulin incretion and moderate rise in lactate concentration. No disorder of fat and uric acid metabolism and acid-base equilibrium was observed. Nor was there intravascular volume dilution, as measured by protein, albumin and haemoglobin concentration and haematocrit. There was a significant fall in phosphate concentration due to increased phosphate utilisation. Calcium concentration was also significantly decreased. Excretion of sodium was 10 mmol/h of potassium 4 mmol/h, phosphate 0.02 mmol/h and of magnesium 0.27 mmol/h. Sodium balance was positive in six patients, potassium and phosphate balance in five, magnesium and waterbalance in eight. There was no change in transaminases and lactate dehydrogenase. A typical sign of carbohydrate infusion was the slight rise in bilirubin concentration by 6.84 mumol/l. The tested carbohydrate combination can, at the stated rate of administration, cover the entire daily energy needs of an adult.
mesh_terms: D001798:Blood Proteins / Q000378:metabolism; D002118:Calcium / Q000097:blood; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D005632:Fructose / Q000008:administration & dosage; D005947:Glucose / Q000008:administration & dosage; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000097:blood; D007770:L-Lactate Dehydrogenase / Q000097:blood; D007773:Lactates / Q000097:blood; D008274:Magnesium / Q000652:urine; D008297:Male; D008660:Metabolism / Q000187:drug effects*; D009318:Natriuresis; D010288:Parenteral Nutrition; D010710:Phosphates / Q000097:blood / Q000652:urine; D011188:Potassium / Q000652:urine; D012709:Serum Albumin / Q000378:metabolism; D013997:Time Factors; D000637:Transaminases / Q000097:blood; D014993:Xylitol / Q000008:administration & dosage
chemical_list: D001798:Blood Proteins; D004040:Dietary Carbohydrates; D006454:Hemoglobins; D007328:Insulin; D007773:Lactates; D010710:Phosphates; D012709:Serum Albumin; D005632:Fructose; D007770:L-Lactate Dehydrogenase; D000637:Transaminases; D008274:Magnesium; D005947:Glucose; D011188:Potassium; D002118:Calcium; D014993:Xylitol
vernacular_title: Stoffwechselwirkungen einer Kohlenhydratkombinationslösung (Glucose, Fructose, Xylit 2:2:1) bei parenteraler Ernährung