Studies on an acquired inhibition of factor VIII induced by penicillin allergy.
An inhibitor of antihaemophilic globulin has been found in association with penicillin allergy. Inhibitor activity was detected after a severe reaction of penicillin. Neutralization studies showed the activity resided in an IgG globulin with kappa light chains. Experiments with insolubilized gammaglobulin demonstrated that the activity of the inhibitor was found in a specific penicillin antibody.
D000906:Antibodies; D000888:Antibodies, Anti-Idiotypic; D002512:Cephalothin / Q000494:pharmacology; D002846:Chromatography, Affinity; D004342:Drug Hypersensitivity; D005169:Factor VIII / Q000037:antagonists & inhibitors*; D005839:Gentamicins / Q000494:pharmacology; D006801:Humans; D007074:Immunoglobulin G; D007145:Immunoglobulin kappa-Chains; D008297:Male; D008875:Middle Aged; D009500:Neutralization Tests; D010400:Penicillin G / Q000276:immunology; D010406:Penicillins / Q000009:adverse effects*
D000906:Antibodies; D000888:Antibodies, Anti-Idiotypic; D005839:Gentamicins; D007074:Immunoglobulin G; D007145:Immunoglobulin kappa-Chains; D010406:Penicillins; D005169:Factor VIII; D010400:Penicillin G; D002512:Cephalothin