Renal ultrastructural changes induced by calcium EDTA in rats.
Calcium ethylenediaminetetraacetate (CaEDTA) was found to induce definite ultrastructural changes in the rat kidney, when infused intravenously at toxic doses (6 mmoles/kg/24 h). These changes consisted of increased vacuolation and lysosomal activity in the proximal tubular epithelium and decreased electron density of the glomerular basement membrane. No abnormalities were seen in the mitochondria.
D000818:Animals; D004492:Edetic Acid / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects* / Q000648:ultrastructure; D007687:Kidney Tubules, Proximal / Q000187:drug effects / Q000648:ultrastructure; D008297:Male; D051381:Rats
D004492:Edetic Acid