[The relationship between the activity of microsomal enzymes and pulmonary carcinogenesis in mice].
Under study was the effect of phenobarbital, medinal and aminazine on the development of lung tumors in mice, as well as on the content of cytochrome P-450 in rat liver microsomes. Phenobarbital and medinal administration resulted in a 2-8 fold increase in cytochrome P-450 amount. Aminazine would reduce the latter but insignificantly. The number of urethan induced lung adenomas in mice was reduced by 64 per cent in phenobarbital exposure while medinal yielded only the decrease by 25-44 per cent. Aminazine failed to effect urethan carcinogenesis. Medinal would also suppress the development of DMBA induced lung tumors in mice by 34 per cent, but MC-by 50 per cent.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000236:Adenoma / Q000139:chemically induced / Q000201:enzymology; D000818:Animals; D000970:Antineoplastic Agents; D001462:Barbital / Q000627:therapeutic use; D002746:Chlorpromazine / Q000627:therapeutic use; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D008175:Lung Neoplasms / Q000139:chemically induced / Q000201:enzymology / Q000517:prevention & control*; D008297:Male; D008748:Methylcholanthrene; D051379:Mice; D008815:Mice, Inbred Strains; D008862:Microsomes, Liver / Q000201:enzymology*; D009374:Neoplasms, Experimental; D010634:Phenobarbital / Q000627:therapeutic use; D014520:Urethane
D000970:Antineoplastic Agents; D014520:Urethane; D008748:Methylcholanthrene; D015127:9,10-Dimethyl-1,2-benzanthracene; D001462:Barbital; D003577:Cytochrome P-450 Enzyme System; D002746:Chlorpromazine; D010634:Phenobarbital
Zavisimost' legochnogo kantserogeneza u mysheĭ ot aktivnosti mikrosomal'nykh fermentov