title: The stimulatory effect of kojic acid on the production of aflatoxin by isolates of Aspergillus flavus Link.
abstract: Kojic acid at the levels of 0.01, 0.1, and 1.0% (w/v) was incorporated in the growth media of Aspergillus flavus. In the presence of 0.01% of kojic acid, isolates I, II, and III produced 157, 113, and 135% aflatoxin, respectively, as compared to the control. At the highest level of kojic acid, i.e. 1%, aflatoxin production was inhibited to 74% in isolate I, but was little affected in isolate II (104%) and strongly inhibited in isolate III (54%). Kojic acid, at a concentration of 0.1%, was still stimulatory to isolate II, while it was inhibitory to isolates I and III. The dry weight of mycelia of the three isolates was not affected by kojic acid addition.
mesh_terms: D000348:Aflatoxins / Q000096:biosynthesis*; D001231:Aspergillus flavus / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D009183:Mycotoxins / Q000494:pharmacology*; D011714:Pyrans / Q000494:pharmacology*; D011753:Pyrones / Q000494:pharmacology*
chemical_list: D000348:Aflatoxins; D009183:Mycotoxins; D011714:Pyrans; D011753:Pyrones