Somatostatin does not suppress plasma parathyroid hormone.
The effect of somatostatin on plasma parathyroid hormone (PTH) was studied in 6 subjects with normal parathyroid function and one patient with a parathyroid adenoma. In 5 subjects, including the one with the parathyroid adenoma, plasma PTH was measured by radioimmunoassay during a 4-hour infusion of somatostatin (500 mug/h). In 2 subjects, PTH responses to EDTA were compared with those observed during a simultaneous infusion of somatostatin and EDTA. In no instance was ther a discernible effect of the somatostatin infusion on plasma PTH. These results demonstrate that somatostatin does not suppress plasma PTH.
D000328:Adult; D004492:Edetic Acid / Q000494:pharmacology; D005260:Female; D005934:Glucagon / Q000097:blood; D006801:Humans; D006961:Hyperparathyroidism / Q000378:metabolism; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood* / Q000378:metabolism; D013004:Somatostatin / Q000494:pharmacology*
D010281:Parathyroid Hormone; D013004:Somatostatin; D005934:Glucagon; D004492:Edetic Acid