title: Carbon-11-labeled methylated polyamine analogs: uptake in prostate and tumor in animal models.
abstract: The polyamines putrescine, spermine, and spermidine were methylated by the addition of carbon-11-labeled formaledehyde followed by sodium  borohydride. High labeling yields wrbon-11-labeled formaldehyde followed by sodium borohydride. High labeling yields were obtained and the final products were purified by simply boiling the solution. This decomposed the excess sodium borohydride and removed the volatile impurities. The final radiochemical purity of all the methylated compounds was above 85%. All three methyltated compounds accumulated in the prostates of male rats and the distribution of N-methyl-1,4-diaminobutane (the putrescine analog) was very similar to that previously obtained with tritiated putrescine. The uptake of the putrescine analog in both the prostate and in mouse tumor was slightly higher than that obtained with the other two analogs studied. Utilizing a positron transaxial tomographic scanner and the putrescine analog, we have been able to image the prostate gland of a dog.
mesh_terms: D000818:Animals; D002250:Carbon Radioisotopes; D004285:Dogs; D008297:Male; D008545:Melanoma / Q000175:diagnosis; D008745:Methylation; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000175:diagnosis; D011073:Polyamines; D011471:Prostatic Neoplasms / Q000175:diagnosis*; D011700:Putrescine / Q000031:analogs & derivatives; D011877:Radionuclide Imaging; D051381:Rats; D013095:Spermidine / Q000031:analogs & derivatives; D013096:Spermine / Q000031:analogs & derivatives; D014054:Tomography
chemical_list: D002250:Carbon Radioisotopes; D011073:Polyamines; D013096:Spermine; D013095:Spermidine; D011700:Putrescine