Carbohydrate metabolism in the chronically uremic rat.
The glycogen cycle enzymes amylo1,6-glucosidase, glycogen synthetase (I and D forms) and alpha-glucan phosphorylase (a and b forms) have been assayed for activity in skeletal muscle and hepatic tissues of chronically uremic rats. Significant decreases in muscle amylo-1,6-glucosidase (41%), hepatic phosphorylase (30%) and hepatic synthetase D (30%) activities were observed in uremics, as compared to both sham operted and destricted diet intake controls. Changes in phosphorylase "a" to "b" activity ratios and synthetase I to D activity ratios were found in the uremics. The biochemical significance of these alterations are discussed.
D000818:Animals; D004789:Enzyme Activation; D005959:Glucosidases / Q000378:metabolism*; D006006:Glycogen Synthase / Q000378:metabolism*; D007668:Kidney / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D008297:Male; D009132:Muscles / Q000201:enzymology; D009392:Nephrectomy; D006005:Phosphorylases / Q000378:metabolism*; D051381:Rats; D014511:Uremia / Q000201:enzymology*
D006005:Phosphorylases; D006006:Glycogen Synthase; D005959:Glucosidases