Early changes in the electrocardiogram and vectorcardiogram and myocardial histology following coronary artery ligation in monkeys.
The ramus interventricularis anterior was ligated at different levels (upper, middle, low third) in 12 anesthetized monkeys (Macaca mulatta). Morphological changes and their localization were compared with the electrocardiogram (ECG) in 12 leads and vectorcardiogram (VCG) according to Akulinichev's 5-plane system). The observations were performed for 6-7 hours after ligation. It has been established that upper third ligation of the ramnus interventricularis anterior caused ECG changes chiefly limited to the chest leads. Normalization of the ECG and VCG may occur within 4-6 hours after middle third ligation. In this case, monkeys develop morphological changes in form of insignificant dystrophic changes in the myocardium. This localization of ligature does not seem to disturb collateral blood circulation ensuring myocardial blood supply. Low third ligation was never followed by any normalization. Pathological wave Q on the ECG and its equivalent on the VCG may be observed in case of myocardial damage without large necrotic foci. In such cases, wave Q may decrease after blood supply improvement in the damaged focus.
D000818:Animals; D003097:Collateral Circulation; D003331:Coronary Vessels / Q000503:physiopathology*; D000882:Haplorhini; D008026:Ligation; D008253:Macaca mulatta; D009206:Myocardium / Q000473:pathology*; D014672:Vectorcardiography