Demethylchlortetracycline-binding proteins in uninvolved gastric mucosa of gastric carcinoma and gastric ulcer patients. Demonstration of a difference between the uninvolved mucosa of ulcer and cancer patients.
The uninvolved gastric mucosa of gastric ulcer and gastric carcinoma patients has been compared in in vitro studies as regards their capacity to bind demethylchlortetracycline (DMCT). Dialysis experiments demonstrated excessive binding of DMCT in gastric cancer. Several electrophoretic fractions were observed that bound DMCT; it was demonstrated that these fractions differed in the uninvolved mucosa of gastric ulcer and gastric cancer patients.
D000230:Adenocarcinoma / Q000378:metabolism*; D003707:Demeclocycline / Q000378:metabolism* / Q000494:pharmacology; D003956:Dialysis; D004588:Electrophoresis, Cellulose Acetate; D005753:Gastric Mucosa / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D011485:Protein Binding / Q000187:drug effects; D013274:Stomach Neoplasms / Q000378:metabolism*; D013276:Stomach Ulcer / Q000378:metabolism*
D003707:Demeclocycline