[Long-term investigations of the influence of corticosteroids on lens transparency in rats (author's transl)].
Both a systemic cortisol treatment (10 mg/kg, daily, s.c.) for 275 days and a local administration of prednisolone eye drops (1%, 4 times daily) for 150 days failed to induce morphologic lens changes in wistar rats. Possible reasons for the different reactions to steroid treatment of human and animal lenses are discussed.
D000818:Animals; D002386:Cataract / Q000139:chemically induced*; D006854:Hydrocortisone / Q000008:administration & dosage / Q000009:adverse effects*; D007908:Lens, Crystalline / Q000187:drug effects / Q000378:metabolism; D008134:Long-Term Care; D011239:Prednisolone / Q000008:administration & dosage / Q000009:adverse effects*; D051381:Rats
D011239:Prednisolone; D006854:Hydrocortisone
Langzeituntersuchungen über den Einfluss von Kortikosteroiden auf die Linsentransparenz bei Ratten