[Effect of the administration of 9,12 dimethyl-1,2 benzanthracene on the plasma and pituitary levels of prolactin in rats during the estrous cycle].
Plasma determination of prolactin in the Rat after administration of DMBA has shown that the hormonal peak was practically suppressed whereas in the pituitary the concentration of prolactin 4 was much higher than the one found in the controls whatever the oestral state. The experiments reported concerning plasma and pituitary, permit us to propose several possible mechanisms for the carcinogenic action of DMBA.
D000818:Animals; D001551:Benz(a)Anthracenes / Q000494:pharmacology*; D004971:Estrus; D005260:Female; D010902:Pituitary Gland / Q000378:metabolism*; D011247:Pregnancy; D011388:Prolactin / Q000097:blood / Q000378:metabolism*; D051381:Rats; D013997:Time Factors
D001551:Benz(a)Anthracenes; D011388:Prolactin
Effet de l'administration du 9.12 DIMETHYL-1.2 benzanthracène sur les taux plasmatiques et hypophysaires de prolactine chez la Ratte au cours du cycle oestral