Possible mode of action of nitroglycerin on heart mitochondria.
Nitroglycerin has no effect on the electron transport and oxidative phosphorylation of isolated rabbit heart mitochondria at 5 X 10(-4) M and lower concentrations. However, it diminished the phosphate-induced energy-dependent potassium fluxes through the mitochondrial membrane in both directions; thus it was able to prevent the impairment of the efficiency of oxidative phosphorylation produced by increased ion transport.
D000818:Animals; D004579:Electron Transport; D008929:Mitochondria, Heart / Q000187:drug effects / Q000378:metabolism*; D008933:Mitochondrial Swelling / Q000187:drug effects; D005996:Nitroglycerin / Q000494:pharmacology*; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D011817:Rabbits
D005996:Nitroglycerin