title: Bladder muscle contractility. Comparative effects and mechanisms of action of atropine, propantheline, flavoxate, and imipramine.
abstract: The anticholinergic and antispasmodic activity of atropine, propantheline, imipramine, and flavoxate were judged by each drug's ability to inhibit bethanechol chloride and barium chloride-induced canine detrusor contractions. In this in vitro model, atropine and propantheline are pure anticholinergic agents. Imipramine significantly decreases both bethanechol and barium-induced contractions, while flavoxate only minimally inhibits the response to either stimulant.
mesh_terms: D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D001464:Barium / Q000037:antagonists & inhibitors; D001626:Bethanechol Compounds / Q000037:antagonists & inhibitors; D002712:Chlorides / Q000037:antagonists & inhibitors; D004285:Dogs; D005260:Female; D005419:Flavonoids / Q000494:pharmacology*; D005422:Flavoxate / Q000494:pharmacology*; D007099:Imipramine / Q000494:pharmacology*; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects*; D011413:Propantheline / Q000494:pharmacology*; D011950:Receptors, Cholinergic / Q000187:drug effects; D013997:Time Factors; D001743:Urinary Bladder / Q000187:drug effects*
chemical_list: D001626:Bethanechol Compounds; D002712:Chlorides; D005419:Flavonoids; D011950:Receptors, Cholinergic; D011413:Propantheline; D001464:Barium; D005422:Flavoxate; D001285:Atropine; D007099:Imipramine