[Effect of cyclophosphamide on themetabolism of erythrocytes].
Cyclophosphamide was applied i.p. in the dose of 100 mg kg-1 to rats. After one, two, three, and seven days the animals were killed and in the collected heparinized blood the incorporation of o-phosphate 32P in erythrocytes was determined in vitro at 37 degrees C and in 35 minutes. Decreased incorporation in animals with Cyclophosphamide indicated, compared with the control, disturbed metabolism of phosphate. The method can be applied as a criterion of secondary toxic effects in the treatment of cancerostatics of alkylation type.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D003520:Cyclophosphamide / Q000009:adverse effects / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D010710:Phosphates / Q000097:blood; D010761:Phosphorus Radioisotopes; D051381:Rats
D010710:Phosphates; D010761:Phosphorus Radioisotopes; D003520:Cyclophosphamide
Vliv cyklofosamidu na metabolismus erytrocytů