Fasting blunts the TSH response to synthetic thyrotropin-releasing hormone (TRH).
Thyrotropin (TSH) responses to intravenous thyrotropin-releasing hormone (TRH) were studied in 9 men after 12 and 36-h fasts separated by more than a week and performed in random order. The TSH, basally and in response to TRH, was significantly lower after the 36-h fast compared to that after 12 h. The mechanism for this effect is not clear, but may be related to the altered hormonal or fuel status associated with prolonged fasting.
D005215:Fasting; D011863:Radioimmunoassay; D013972:Thyrotropin / Q000378:metabolism*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*; D013997:Time Factors
D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin