A feedback control of cell cycle parameters in Tetrahymena.
Protein and RNA contents of individual cells were measured cytophotometrically and related to the duration of individual generation times. Constant amounts of RNA per cell at division, and generation time-dependent protein contents, resulted in generation time-specific RNA/protein ratios. Experimental reduction of these ratios by inhibition of RNA synthesis stimulated premature macronuclear S phases.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D003609:Dactinomycin / Q000494:pharmacology; D011506:Proteins / Q000378:metabolism; D012313:RNA / Q000096:biosynthesis / Q000378:metabolism; D013769:Tetrahymena pyriformis / Q000254:growth & development*
D011506:Proteins; D003609:Dactinomycin; D012313:RNA