Effects of butylated hydroxyanisole in Drosophila melanogaster.
The standard sex-linked recessive lethal test using "Basc" virgin females and treated Canton S males was used to test potential mutagenicity of ingested butylated hydroxyanisole (BHA) on mature spermatozoa. Ethyl methanesulfonate (EMS) was employed as a positive control and at lower concentrations a roughly linear dose response curve resulted. Flies treated with BHA yielded no higher frequency of sex-linked recessive lethals than did control flies, and statistical analysis confirmed that a high confidence level, the BHA treatment used did not double the spontaneous frequency of sex-linked recessive lethals.
D000818:Animals; D000840:Anisoles / Q000633:toxicity*; D002083:Butylated Hydroxyanisole / Q000633:toxicity*; D004331:Drosophila melanogaster / Q000187:drug effects*; D005020:Ethyl Methanesulfonate / Q000494:pharmacology; D005503:Food Additives / Q000494:pharmacology; D005804:Genes, Lethal; D005808:Genes, Recessive; D008297:Male; D009153:Mutagens; D009154:Mutation; D012737:Sex Factors; D013094:Spermatozoa / Q000187:drug effects
D000840:Anisoles; D005503:Food Additives; D009153:Mutagens; D002083:Butylated Hydroxyanisole; D005020:Ethyl Methanesulfonate