title: Membrane-fusions and cytoplasmic bridges in the cells of the developing cerebellum.
abstract: In the developing cerebellum of the neonate rats membrane-fusions and cytoplasmic bridges between cells were observed. These membrane-fusions were characterized by the presence of loops of membrane and cytoplasmic bridges between the two limits of the membrane-fusions. They were found between Purkinje cells, Purkinje cells and the migratory cells, mitotically potent cells of the external granular layer, and differentiating granule cells of the internal granular layer. The membrane-fusions were found to be a transient developmental phenomenon. Issues pertaining to the universality of membrane-fusions, their significance in the induction for cell differentiation, and the problem of  fixation artifacts are discussed.
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002454:Cell Differentiation; D002531:Cerebellum / Q000254:growth & development / Q000648:ultrastructure*; D005404:Fixatives; D007365:Intercellular Junctions / Q000648:ultrastructure*; D008854:Microscopy, Electron; D011689:Purkinje Cells / Q000648:ultrastructure; D051381:Rats
chemical_list: D005404:Fixatives