False-positive reactions of cerebrospinal fluid and diluted sera with the coccidioidal latex-agglutination test.
Most samples of cerebrospinal fluid from 49 patients with or without coccidioidomycosis yielded positive agglutination with the Hyland ("CM") latex-particle agglutination test. Furthermore, simple dilution of sera from patients with or without coccidioidomycosis yielded a strong agglutination reaction with the latex particle agglutination test reagent. These reactions were found with three lots of the latex-particle agglutination test reagent. One lot latex particles was found to give agglutination reactions merely by addition of saline solution or water, though a second lot did not. It is advisable, therefore, that the latex-particle agglutination test not be applied to cerebrospinal fluid, and that it be applied cautiously, particularly with diluted sera.
D003047:Coccidioidomycosis / Q000097:blood / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D003168:Complement Fixation Tests; D005189:False Positive Reactions; D006801:Humans; D005779:Immunodiffusion; D007840:Latex; D007841:Latex Fixation Tests / Q000592:standards*; D008581:Meningitis / Q000175:diagnosis; D008863:Microspheres; D011233:Precipitin Tests
D007840:Latex