A radioiodinated bretylium analog as a potential agent for scanning the adrenal medulla.
Studies with radioiodinated bretylium analogs (RIBA) suggested that the p-isomer was capable of concentrating in adrenal medulla. The present studies with 125I-p-RIBA in rats and dogs confirm this property and show its marked and persistent affinity for the adrenal medulla. Analogous studies with 14C-p-IBA indicate that it is the quaternary form of the drug that is retained by the adrenal and that high thyroidal radioactivity following 125I-p-RIBA administration is due to in vivo deiodination of the drug.
D000307:Adrenal Gland Diseases / Q000175:diagnosis; D000313:Adrenal Medulla; D000818:Animals; D001949:Bretylium Compounds; D004285:Dogs; D007457:Iodine Radioisotopes; D011877:Radionuclide Imaging; D051381:Rats
D001949:Bretylium Compounds; D007457:Iodine Radioisotopes