title: Condylomata acuminata and squamous cell carcinoma.
abstract: Until recently, condyloma acuminatum has been considered to be a benign growth with no malignant potential. The histologically similar, yet clinically different, giant condyloma acuminatum (Buschke-Lowenstein tumor) has been defined as a mass with downward growth that has no histologic malignant changes, although the clinical course may be malignant. A review of the literature yielded 65 cases of malignant degeneration of this type of tumor and supports the concept that either condyloma acuminatum or the Buschke-Lowenstein tumor may precede or be associated with squamous cell carcinoma. A patient presenting with condyloma acuminatum in whom invasive squamous carcinoma of the penis developed exemplifies the transitory character of the disease.
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000209:etiology* / Q000473:pathology; D003218:Condylomata Acuminata / Q000150:complications* / Q000473:pathology / Q000628:therapy; D006801:Humans; D008297:Male; D027383:Papillomaviridae; D010412:Penile Neoplasms / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D010413:Penis / Q000473:pathology; D027382:Polyomaviridae