[Occurrence of cytotoxic anti-HL-A antibodies in female patients sensitized to Rh antigens].
The frequency of sentization to HL-A system antigens in the categories of Rh-sentized patients was studied, considering the observation that in this category the precentage of senzitization to the system of transplantation antigens is much higher than in other groups. A total of 211 samples of sera of Rh-sensitized patients were examined of which 127 were sensitized to the HL-A system at the same time, while the remaining 74 showed absence of HL-A antibodies. For work the technique of Indirect antihuman globulin test was used (for Rh-sentization) while for HL-A system sensitization examination, the Two-stage microlymphocytotoxicyty method of Terasaki, modified by Dausset, was used. In this study the possibility of the favourable influence of sensitization to the erythrocyte antigen Rh-system and sensitization to transplantation antigens during pregnancy are discussed.
D000888:Antibodies, Anti-Idiotypic / Q000302:isolation & purification*; D003298:Coombs Test; D003601:Cytotoxicity Tests, Immunologic; D004899:Erythroblastosis, Fetal / Q000276:immunology; D005260:Female; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D006801:Humans; D011247:Pregnancy; D012204:Rh-Hr Blood-Group System
D000888:Antibodies, Anti-Idiotypic; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D012204:Rh-Hr Blood-Group System
Pojava citotoksicnih anti-HL-A antitela u pacijentkinja senzibilisanih na antigene Rhesus-sistema