title: [Jacksonian fits and threatened premature labour (the effect of valium, prepar and antiepileptic drugs on the fetus and uterine contractility ante and intra partum) (author's transl)].
abstract: The case is reported of a 30-year-old patient whose fifth pregnancy (para 2, no living children) was complicated by the necessity of surgical removal of a stage II astrocytoma. Threatened premature labour was averted by the continuous administration of Prepar as from the 25th week of pregnancy and spontaneous vaginal delivery of a live-born infant was achieved in the 35th week. The development of repeated Jacksonian fits necessitated the administration of high doses of Valium (215 mg i.v. over a 50-nour period) both pre and intra partum, over and above the long-term antiepileptic maintenance therapy which the patient had received throughout the entire pregnancy. The fetal heart rate was not affected by Valium even at such high dosage. This case serves to illustrate that if the indication arises, high doses of Valium may be given before and during labour in conjunction with long-term antiepileptic drugs and Prepar apparently without adverse effects on the fetus or on uterine activity.
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use; D001254:Astrocytoma / Q000601:surgery; D003975:Diazepam / Q000627:therapeutic use*; D004828:Epilepsies, Partial / Q000150:complications / Q000188:drug therapy*; D005260:Female; D005333:Fetus / Q000187:drug effects; D006801:Humans; D009119:Muscle Contraction / Q000187:drug effects; D007752:Obstetric Labor, Premature / Q000517:prevention & control*; D011247:Pregnancy; D011248:Pregnancy Complications; D011412:Propanolamines / Q000627:therapeutic use*; D012312:Ritodrine / Q000627:therapeutic use*; D014599:Uterus / Q000187:drug effects
chemical_list: D000927:Anticonvulsants; D011412:Propanolamines; D012312:Ritodrine; D003975:Diazepam
vernacular_title: Jackson-Anfälle und drohende Frühgeburt (Der Einfluss von Valium, Prepar und Antiepileptika auf den Fetus und die Wehentätigkeit prae und intra partum)