A new case of monoclonal IgA kappa cold agglutinin with anti-Pr1d specificity in a patient with persistent HB antigen cirrhosis.
A new case of cold agglutinin disease in a patient who had a long lasting Raynaud's phenomenon without hemolysis and a persistent HB antigen cirrhosis, is reported. The cold agglutinin is a monoclonal IgA kappa antibody which reacts at 4degreesC to a titer of 256. As the three other cases described in the literature, it demonstrates Pr1 specificity. The eluate from human cells reacts with rat and dog cells whose receptor is destroyed by both papain and neuraminidase, thus eliciting the characteristic Pr1d specificity.
D000368:Aged; D000373:Agglutinins / Q000032:analysis*; D000918:Antibody Specificity; D001323:Autoantibodies / Q000032:analysis*; D003080:Cold Temperature; D005260:Female; D006511:Hepatitis B Antigens; D006801:Humans; D007070:Immunoglobulin A; D007147:Immunoglobulin Light Chains / Q000032:analysis*; D007145:Immunoglobulin kappa-Chains / Q000032:analysis*; D008103:Liver Cirrhosis / Q000276:immunology*
D000373:Agglutinins; D001323:Autoantibodies; D006511:Hepatitis B Antigens; D007070:Immunoglobulin A; D007147:Immunoglobulin Light Chains; D007145:Immunoglobulin kappa-Chains