An ontogenic study of histamine and mast cells in the fetal rhesus monkey.
This study was designed to determine the presence of cell-bound histamine and mast cells, if any, in the lung and skin of nonhuman primate fetuses and neonates. The results indicate that cell-bound histamine can be detected in both tissues of the rhesus monkey fetus by 60 days of gestation, the earliest age  examined, at levels that are 2% to 3% of levels present in yearling animals. Levels increase markedly during the least 1 1/2 mo of gestation; however, at birth, levels are only 12% to 46% of those observed in the yearling and are lower than levels observed at 150 days of gestation. Most cell numbers in lung and skin of the fetus closely parallel histamine content.
D000818:Animals; D000831:Animals, Newborn; D005260:Female; D005333:Fetus / Q000276:immunology*; D005865:Gestational Age; D000882:Haplorhini; D006632:Histamine / Q000032:analysis*; D008168:Lung / Q000166:cytology / Q000276:immunology; D008251:Macaca / Q000276:immunology*; D008253:Macaca mulatta / Q000276:immunology*; D008407:Mast Cells / Q000276:immunology*; D011247:Pregnancy; D012867:Skin / Q000166:cytology / Q000276:immunology
D006632:Histamine