title: Red cell membrane proteins abnormality in paroxysmal nocturnal hemoglobinuria and in in vitro induced PNH-like erythrocytes.
abstract: The abnormality of the reducell membrane proteins, in paroxysmal nocturnal hemoglobinuria (PNH) red cells and in PNH-like ones induced in vitro by D-penicillamine and N-acetyl-l-cysteine, is described. The electrophoresis was effected by a vertical urea starch-gel system. In PNH there is a loss of 5 protein bands and a diminution of one of the remaining bands, and in PNH-like red cells there is a loss of 2 or 3 protein bands.
mesh_terms: D000111:Acetylcysteine / Q000494:pharmacology; D004592:Electrophoresis, Starch Gel; D004910:Erythrocyte Membrane / Q000032:analysis / Q000187:drug effects; D004912:Erythrocytes / Q000032:analysis; D006457:Hemoglobinuria, Paroxysmal / Q000175:diagnosis*; D006801:Humans; D008565:Membrane Proteins / Q000097:blood*; D010396:Penicillamine / Q000494:pharmacology
chemical_list: D008565:Membrane Proteins; D010396:Penicillamine; D000111:Acetylcysteine