Neonatal acidosis associated with transient methylmalonicaciduria and vitamin B12 deficiency.
Investigation of a neonate presenting with a metabolic acidosis, vomiting and an apnoeic attack revealed abnormal urinary excretion of methylmalonic acid (MMA) associated with a low serum vitamin B12. Restriction of dietary protein was followed by normalisation of acid-base balance. Reintroduction of normal daily protein intake did not precipitate flrther acidosis or increased excretion of MMA. The transient methylmalonicaciduria was probably due to deficiency of vitamin B12.
D000136:Acid-Base Equilibrium; D000138:Acidosis / Q000150:complications*; D006801:Humans; D007231:Infant, Newborn; D008314:Malonates / Q000652:urine*; D008661:Metabolism, Inborn Errors; D008764:Methylmalonic Acid / Q000652:urine*; D014806:Vitamin B 12 Deficiency / Q000150:complications*
D008314:Malonates; D008764:Methylmalonic Acid