Antiparasitic nitroimidazoles. 8. Derivatives of 2-(4-formylstyryl)-5-nitro-1-vinylimidazole.
A series of 33 thioacetals and hydrazones of 2-(4-formylstyryl)-5-nitro-1-vinylimidazole was prepared and examined for antitrypanosomal properties. The thioacetals were inactive as antitrypanosomal agents but three hydrazones derived from N-aminoguanidine, pyridylacethohydrazide chloride (Girard reagent P), and dimethylaminoacetohydrazide (Girard reagent D) displayed good activity against Trypanosoma rhodesiense.
D000080:Acetals / Q000138:chemical synthesis / Q000627:therapeutic use; D000818:Animals; D014355:Chagas Disease / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D006835:Hydrazones / Q000138:chemical synthesis / Q000627:therapeutic use; D051379:Mice; D009593:Nitroimidazoles / Q000138:chemical synthesis* / Q000627:therapeutic use; D013329:Structure-Activity Relationship; D013343:Styrenes / Q000138:chemical synthesis / Q000627:therapeutic use; D014344:Trypanocidal Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D014347:Trypanosoma brucei gambiense; D014349:Trypanosoma cruzi; D014353:Trypanosomiasis, African / Q000188:drug therapy
D000080:Acetals; D006835:Hydrazones; D009593:Nitroimidazoles; D013343:Styrenes; D014344:Trypanocidal Agents