Scleromyxedema.
An unusual, nodulocystic form of scleromyxedema (lichen myxedematosus) developed in a 48-year-old man with a six-year history of psoriasis. The scleromyxedema responded to intermittent therapy with melphalan and prednisone. Dermabrasion smoothed and softened the skin and increased the mobility of the perioral skin. Two months after remission of the skin lesions, psoriasis recurred.
D003869:Dermabrasion; D006801:Humans; D008297:Male; D008558:Melphalan / Q000627:therapeutic use; D008875:Middle Aged; D009083:Mucopolysaccharidoses / Q000150:complications; D009230:Myxedema / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D010265:Paraproteinemias / Q000150:complications; D011241:Prednisone / Q000627:therapeutic use; D011565:Psoriasis / Q000150:complications; D012008:Recurrence; D012871:Skin Diseases / Q000150:complications / Q000175:diagnosis* / Q000628:therapy
D008558:Melphalan; D011241:Prednisone