title: Cerebral and cardiac toxicity of a small dose of lignocaine.
abstract: A patient is reported in whom an intravenous bolus injection of 50 mg lignocaine produced extreme sinus bradycardia (rate 14 to 20/min). Only 2 patients with such a response to a similarly small dose have been previously reported, but these reports indicate clearly that careful electrocardiographic monitoring is advisable when lignocaine is administered.
mesh_terms: D001145:Arrhythmias, Cardiac / Q000188:drug therapy; D001919:Bradycardia / Q000139:chemically induced*; D004562:Electrocardiography; D004830:Epilepsy, Tonic-Clonic / Q000139:chemically induced*; D006801:Humans; D007275:Injections, Intravenous; D008012:Lidocaine / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D013610:Tachycardia / Q000188:drug therapy
chemical_list: D008012:Lidocaine