[Functional study of metal and radiation in the mechanism of toxic action of plutonium injected in its elemental form].
A ponderal variations study of rats contaminated either with the same metal mass of two isotopes 238Pu and 239Pu or with an equal activity level entitles us to conclude that plutonium toxicity for below 50 muCi/kg levels arises from particles alpha. For higher levels, about 120 muCi/kg, the quantity effect of metal has an influence on localisation and repartition of toxicity. Beneficial effect of oxygenotherapy for 120 muCi/kg appears only after a delay of several days, the time required for toxic manifestation, confirming in acute intoxication, the function of ionising radiation emitted by the metal.
D000512:Alpha Particles; D000818:Animals; D001835:Body Weight / Q000187:drug effects / Q000528:radiation effects*; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D010100:Oxygen / Q000627:therapeutic use; D011005:Plutonium / Q000378:metabolism / Q000633:toxicity*; D011830:Radiation Effects; D011833:Radiation Injuries, Experimental / Q000188:drug therapy; D011868:Radioisotopes; D051381:Rats; D013329:Structure-Activity Relationship
D011868:Radioisotopes; D011005:Plutonium; D010100:Oxygen
Etude du rôle du métal et des rayonnements dans le mécanisme d'action toxigue du plotonium injecté Sous forme de monomère