Quantitative autoradiographic studies on the competition of diethylnitrosamine (DENA) and 9,10-dimethyl-1,2-benzanthracene (DMBA) in the liver cell of CBA-mice.
In CBA-mice the competition of DENA and DMBA was studied by quantitative autoradiography. During the precancerous phase in DENA-pretreated animals the rate of DMBA-incorporation into DNA/RNA and nuclear proteins was lower as compared to the controls without DENA-pretreatment. Independent of DENA-pretreatment the rate of DMBA-incorporation into the cytoplasm was significantly enhanced in hepatectomized animals. In this experiment the skin as a target organ did not show any quantitatively measurable DMBA-incorporation despite of prolonged autoradiographic exposition time.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000378:metabolism*; D000818:Animals; D001345:Autoradiography; D001551:Benz(a)Anthracenes / Q000378:metabolism*; D002467:Cell Nucleus / Q000378:metabolism; D004052:Diethylnitrosamine / Q000378:metabolism*; D008099:Liver / Q000378:metabolism* / Q000648:ultrastructure; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009602:Nitrosamines / Q000378:metabolism*; D011230:Precancerous Conditions / Q000378:metabolism
D001551:Benz(a)Anthracenes; D009602:Nitrosamines; D004052:Diethylnitrosamine; D015127:9,10-Dimethyl-1,2-benzanthracene