The value of amniotic fluid diamine oxidase estimations in the management of severe rhesus iso-immunization.
Serial estimations of the enzyme, diamine oxidase (D.A.O.) in liquor amnii were made in 82 rhesus sensitised women. Normal levels were found in severe disease with a favourable fetal outcome, but abnormal levels were found in 50% of the pregnancies in which severe disease was associated with fetal death. In addition, when liquor bilirubin levels predicted moderate-severe disease, D.A.O. levels were abnormal in 75% of the pregnancies in which the fetus succumbed. Abnormally low D.A.O. levels in amniotic fluid were frequently associated with the subsequent development of disseminated intra-vascular coagulation in the infant. Serial estimations of D.A.O. in amniotic fluid could be a helphful adjunct to serial liquor bilirubin estimations in the management of severe rhesus iso-immunisation.
D006631:Amine Oxidase (Copper-Containing) / Q000097:blood / Q000378:metabolism*; D000653:Amniotic Fluid / Q000032:analysis / Q000201:enzymology*; D000917:Antibody Formation; D001202:Ascitic Fluid / Q000201:enzymology; D001663:Bilirubin / Q000378:metabolism; D004899:Erythroblastosis, Fetal / Q000201:enzymology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D012204:Rh-Hr Blood-Group System
D012204:Rh-Hr Blood-Group System; D006631:Amine Oxidase (Copper-Containing); D001663:Bilirubin