Toxicology and pharmacological action of anabaena flos-aquae toxin.
Calves, rats, ducks, and goldfish given lethal oral doses of bacteria-free lyophilized cell suspensions of toxic Anabaena flos-aquae died as a result of respiratory arrest. Experiments with selected animals and pharmacological preparations showed that the main effect of the toxin was production of a sustained postsynaptic depolarizing neuromuscular blockade.
D000284:Administration, Oral; D000818:Animals; D002417:Cattle; D000458:Cyanobacteria; D004372:Ducks; D006054:Goldfish; D007275:Injections, Intravenous; D009467:Neuromuscular Depolarizing Agents; D051381:Rats; D012131:Respiratory Insufficiency / Q000139:chemically induced; D014118:Toxins, Biological / Q000494:pharmacology / Q000633:toxicity*
D009467:Neuromuscular Depolarizing Agents; D014118:Toxins, Biological