Absence of penicillin-degrading enzymes in penicillin-resistant strains of Neisseria gonorrhoeae.
Penicillin-resistant and -susceptible strains of Neisseria gonorrhoeae were evaluated for the presence of enzymes capable of degrading penicillin by incubation of [(14)C]benzylpenicillin with resting-cell suspensions of N. gonorrhoeae followed by extraction and chromatography of the labeled antibiotic. No degradative activity was observed.
D009344:Neisseria gonorrhoeae / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D010400:Penicillin G / Q000378:metabolism; D010403:Penicillin Resistance; D010405:Penicillinase / Q000378:metabolism*; D010406:Penicillins / Q000494:pharmacology*
D010406:Penicillins; D010405:Penicillinase; D010400:Penicillin G