[Econazole nitrate. In vitro tests and clinical trial].
Econazole-nitrate is a new potent antifungal drug with a broad spectrum against dermatophytes, yeasts and moulds; in addition it is effective against gram-positive bacteria. Econazole nitrate was tested in-vitro for antifungal and anti-microbial properties. In an open trial 75 patients were treated with a 1 percent econazole cream. Cure was achieved in tinea pedis in 91 percent; in tinea genitocruralis in 100 percent and in tinea corporis in 92 percent. The remainder were greatly improved. 22 patients with erythrasma were cured within 3 weeks.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use*; D003883:Arthrodermataceae / Q000187:drug effects*; D001230:Aspergillus / Q000187:drug effects; D002175:Candida / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D004352:Drug Resistance, Microbial; D004821:Epidermophyton / Q000187:drug effects; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D066298:In Vitro Techniques; D008297:Male; D008826:Microbial Sensitivity Tests; D008864:Microsporum / Q000187:drug effects; D008875:Middle Aged; D003904:Mitosporic Fungi / Q000187:drug effects*; D009566:Nitrates; D009824:Ointments; D014005:Tinea / Q000188:drug therapy*; D014249:Trichophyton / Q000187:drug effects
D000935:Antifungal Agents; D007093:Imidazoles; D009566:Nitrates; D009824:Ointments
Econazol-Nitrat. In-vitro-Testung und klinische Prüfung