Thallium antagonism toward potassium dependent systems.
When a number of Group 1A chlorides were added to yeast solutions which were inhibited by 20 mM Tl+, the greatest restorative effect was shown by KCl, with a lesser effect by NH4Cl. Sodium, rubidium and cesium chlorides had no significant effect on Tl+-inhibited CO2 production, and lithium chloride inhibited the system even further. Removal of potassium ions by dialysis reduced CO2 production by about 70% and the restorative effect of potassium was markedly reduced when this ion was added in the presence of thallium.
D002414:Cations, Monovalent; D002712:Chlorides / Q000494:pharmacology; D006019:Glycolysis / Q000187:drug effects; D011188:Potassium / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000378:metabolism*; D013793:Thallium / Q000494:pharmacology*
D002414:Cations, Monovalent; D002712:Chlorides; D013793:Thallium; D011188:Potassium