Antibody suppression and antiallotype antibodies. II. Interference of circulating antiallotype antibodies with prophylactic treatment against Rh sensitization.
Sera from Rh-sensitized women representing presumable failure of the prophylactic treatment with IgG anti-D (Rh) have been examined for activity against allotype markers on IgG1. Antiallotype antibodies were found with increased frequency compared with a nonsensitized control. In general, however, interference of antiallotype antibodies is not considered to be a great risk of Rh prophylaxis at present. Some requirements which, in this context, may be of importance to the composition and dose of the IgG anti-D-containing preparations used are stressed.
D000372:Agglutination Tests; D000917:Antibody Formation; D005260:Female; D006801:Humans; D007114:Immunization; D007126:Immunoglobulin Allotypes; D007074:Immunoglobulin G; D007165:Immunosuppression Therapy; D007518:Isoantibodies; D011247:Pregnancy; D012204:Rh-Hr Blood-Group System
D007126:Immunoglobulin Allotypes; D007074:Immunoglobulin G; D007518:Isoantibodies; D012204:Rh-Hr Blood-Group System