Role of age and sex in chronic thyroiditis in rats fed 3'-methyl-4-dimethylaminoazobenzene.
Inbred male and female Buffalo strain rats were started at 4, 8, 12, 24, or 52 weeks of age on 0.06% 3'-methyl-4-dimethylaminoazobenzene in a low-protein, choline-deficient diet. Eight-week-old males and females were the most susceptible to the development of chronic thyroiditis, but females were more susceptible than the males. Female rats of other ages developed a slightly higher incidence of thyroiditis than the male rats, the difference being most noticeable for rats 12 weeks old.
D000367:Age Factors; D000818:Animals; D005260:Female; D008297:Male; D008749:Methyldimethylaminoazobenzene; D051381:Rats; D011915:Rats, Inbred BUF; D011919:Rats, Inbred Strains; D012376:Rodent Diseases / Q000139:chemically induced* / Q000473:pathology; D012737:Sex Factors; D013961:Thyroid Gland / Q000473:pathology; D013966:Thyroiditis / Q000139:chemically induced / Q000473:pathology / Q000662:veterinary*; D004124:p-Dimethylaminoazobenzene / Q000031:analogs & derivatives
D008749:Methyldimethylaminoazobenzene; D004124:p-Dimethylaminoazobenzene