title: Bacteriocin production by Neisseria gonorrhoeae.
abstract: Seventeen apparently unrelated isolates of Neisseria gonorrhoeae out of 2,123 tested produced a diffusible growth-inhibitory substance against other gonococci. The inhibitor was destroyed by trypsin, not blocked by bovine serum albumin, and not soluble in chloroform-methanol; each isolate was resistant to the inhibitor it produced. Thus, the substance differs from previously described gonococcal inhibitors, and since it fits the description of a bacteriocin we designated it gonocin. The use of gonocin for typing was complicated by the observation that susceptibility to gonocin appears to depend on the gonococcal colony type.
mesh_terms: D001430:Bacteriocins / Q000096:biosynthesis* / Q000378:metabolism; D001431:Bacteriological Techniques; D008937:Mitomycins / Q000494:pharmacology; D009016:Moraxella / Q000378:metabolism; D009344:Neisseria gonorrhoeae / Q000378:metabolism*; D012710:Serum Albumin, Bovine / Q000494:pharmacology; D013045:Species Specificity; D014357:Trypsin / Q000494:pharmacology
chemical_list: D001430:Bacteriocins; D008937:Mitomycins; D012710:Serum Albumin, Bovine; D014357:Trypsin