title: The relationship between total and ionized calcium in the blood sheep when calcium levels are altered.
abstract: In a series of eight experiments attempts were made to change the levels of calcium in the blood of sheep by intravenous infusions of calcium, EDTA and thyrocalcitonin or changing the acid-base balance by various means. When total calcium levels changed these changes were mirrored closely by changes in the physiologically important ionized calcium fraction (r = 0.839). It is concluded that the total calcium determinations remain valuable indicators of changes in the physiological level of calcium in the blood.
mesh_terms: D000818:Animals; D001639:Bicarbonates / Q000494:pharmacology; D002116:Calcitonin / Q000494:pharmacology; D002118:Calcium / Q000097:blood*; D002122:Calcium Chloride / Q000494:pharmacology; D004492:Edetic Acid / Q000494:pharmacology; D005260:Female; D007773:Lactates / Q000494:pharmacology; D008297:Male; D012756:Sheep / Q000097:blood*; D012972:Sodium Hydroxide / Q000494:pharmacology
chemical_list: D001639:Bicarbonates; D007773:Lactates; D012972:Sodium Hydroxide; D002116:Calcitonin; D004492:Edetic Acid; D002122:Calcium Chloride; D002118:Calcium