title: [Antigastrin therapy in gastric ulcer].
abstract: A brief review of the role of gastrin on gastric secretion and its influence in the genesis of peptic ulcer is made. A report is made of the pharmacological studies of Proglumida and its antigastrin action and the interest its association with Hioscin Butil-Bromuro may represent in the antiulcer therapy. A study is made of 26 patients submitted to a general treatment for peptic ulcer this drug together with a bland diet and psychotherapy. The results were: 19 (73%) cases cured; 6 (23%) cases improved; no results in 1 (4%) case. No secondary side effects appear and the symptomatic response appears 8 days after the treatment is initiated. The dosis used is of 2 tablets before the 3 main meals. Each tablet contains 250 mg of Proglumide and 10 mg of Hioscin Butil-Bromuro. It is considered useful in the antiulcer therapy to have available a drug which can control the physiological effects of gastrin and from this point of view its action is different from that of the antiacids and anticolinergics.
mesh_terms: D000328:Adult; D000368:Aged; D001965:Bromides / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004338:Drug Combinations; D004381:Duodenal Ulcer / Q000188:drug therapy*; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism*; D005755:Gastrins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D005973:Glutamine / Q000031:analogs & derivatives*; D006548:Hernia, Diaphragmatic / Q000188:drug therapy*; D006551:Hernia, Hiatal / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011377:Proglumide / Q000627:therapeutic use*; D012601:Scopolamine / Q000627:therapeutic use*; D012636:Secretory Rate / Q000187:drug effects; D013276:Stomach Ulcer / Q000188:drug therapy*; D013607:Tablets
chemical_list: D001965:Bromides; D004338:Drug Combinations; D005755:Gastrins; D013607:Tablets; D005973:Glutamine; D012601:Scopolamine; D011377:Proglumide
vernacular_title: Terapia antigastrínica en la enfermedad ulcerosa