title: [Chronic lead poisoning: Lead gout with giant tophi on the skin, nephrophathy and porphyrinopathy].
abstract: Chronic lead nephtropathy, secondary gout (lead-gout) and porphyrinuria may develop after long lasting professional exposure to lead. A printer with giant tophi on his hands and feet excreted a significantly higher amount of lead after infusion of calcium EDTA in comparison with a normal control person. This result indicates an increased mobilization of lead from skeletal deposits. Furthermore, the laboratory findings showed renal insufficency and porphyrinuria up to 1316 mug/l (elevation of total porphyrins with slight or no elevation of delta-amino-levulic acid and porphobilinogene). The clinical triad nephropathy, secondary gout and porphyrinuria seems to be a variant of chronic lead poisoning.
mesh_terms: D000368:Aged; D001870:Book Industry; D002908:Chronic Disease; D004492:Edetic Acid; D006073:Gout / Q000150:complications / Q000175:diagnosis / Q000209:etiology* / Q000652:urine; D006801:Humans; D007674:Kidney Diseases / Q000150:complications / Q000209:etiology* / Q000652:urine; D007854:Lead / Q000378:metabolism / Q000652:urine; D007855:Lead Poisoning / Q000150:complications* / Q000652:urine; D008297:Male; D009784:Occupational Diseases; D011166:Porphyrins / Q000652:urine*; D012877:Skin Manifestations; D014527:Uric Acid / Q000097:blood
chemical_list: D011166:Porphyrins; D014527:Uric Acid; D007854:Lead; D004492:Edetic Acid
vernacular_title: Chronische Bleiintoxikation: Bleigicht mit Riesentophi an der Haut, Nephropathie und Porphyrinopathie