Individual responses to methylphenidate and caffeine in children with minimal brain dysfunction.
Eight children with minimal brain dysfunction were studied for their individual responses to two stimulant medications--methylphenidate hydrochloride and caffeine citrate. Four types of behavioural responses were observed in the double-blind crossover experiment: four children responded favourably to both psychostimulants, one responded to methylphenidate alone and two responded to the placebo. The behaviour of one child deteriorated while he was taking methylphenidate and caffeine. In general, methylphenidate was superior to caffeine in diminishing hyperactive and aggressive behaviour. It is apparent that such stimulant medication exerts its therapeutic effects in these two areas primarily and would therefore be useful as one aspect of a complete treatment program for children with this syndrome.
D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy*; D002110:Caffeine / Q000008:administration & dosage*; D002648:Child; D002951:Citrates / Q000008:administration & dosage*; D002986:Clinical Trials as Topic; D004338:Drug Combinations / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000008:administration & dosage*
D002951:Citrates; D004338:Drug Combinations; D008774:Methylphenidate; D002110:Caffeine