Trimethoprim-sulfamethoxazole in the treatment of gonorrhea: comparison with standard treatment schedules.
Several treatment regimens of trimethoprim-sulfamethoxazole (TMP-SMZ) were compared to the USPHS-recommended schedules for treatment of uncomplicated gonorrhea with ampicillin plus probenecid, tetracycline, or aqueous procaine penicillin G in both men and women. TMP-SMZ, six tablets as a single oral dose daily for 3 days, was as effective as the ampicillin or tetracycline schedules. The drug was well tolerated.
D000667:Ampicillin / Q000627:therapeutic use; D004334:Drug Administration Schedule; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D005260:Female; D006069:Gonorrhea / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000302:isolation & purification; D010402:Penicillin G Procaine / Q000627:therapeutic use; D011339:Probenecid / Q000627:therapeutic use; D013420:Sulfamethoxazole / Q000008:administration & dosage / Q000627:therapeutic use*; D013752:Tetracycline / Q000627:therapeutic use; D014295:Trimethoprim / Q000008:administration & dosage / Q000627:therapeutic use*
D004338:Drug Combinations; D010402:Penicillin G Procaine; D000667:Ampicillin; D014295:Trimethoprim; D013752:Tetracycline; D013420:Sulfamethoxazole; D011339:Probenecid