[Chronic lymphoid leukemia and multiple myeloma].
The authors report a case of multiple kappa myeloma comboned with chronic lymphoid leukemia. The chronic lymphoid leukemia had evolved over a 13-year period in the classical manner, without serum or urnary monoclonal immunoglobulins. The multiple myeloma with blood and urinary kappa chains appeared suddenly with a typical clinical and radiological picture accompanied by renal insufficiency. Thd diagnosis was confirmed by the demonstration of both lymphocyte and plasmocyte cell proliferation and a study of the ultrastructure which showed the sarcomatous and secretory character of the plasmocytes. A study of plasmocyte subpopulation showed the proliferation of B lymphocytes. A combination of chronic lymphoid leukemia and multiple myeloma is exceptional. The physiopathological interpretation (mono or biclonal proliferation) is discussed in the light of current nosological conceptions concerning lymphoproliferative disorders.
D001402:B-Lymphocytes / Q000473:pathology; D001853:Bone Marrow / Q000473:pathology; D001854:Bone Marrow Cells; D006801:Humans; D007145:Immunoglobulin kappa-Chains; D007676:Kidney Failure, Chronic / Q000150:complications; D007945:Leukemia, Lymphoid / Q000150:complications* / Q000276:immunology; D008099:Liver / Q000473:pathology; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000276:immunology; D010950:Plasma Cells / Q000473:pathology; D011859:Radiography; D012888:Skull Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology; D013154:Spleen / Q000473:pathology
D007145:Immunoglobulin kappa-Chains
Leucémie lymphoïde chronique et myélome multiple