[Regulation of ionized calcium in the cytosol of muscle cells during rest: action of dantrolene on the sarcoplasmic reticulum].
Dantrolene sodium, a hydantoin derivative with skeletal muscle relaxant properties, quickly reduces the cytosolic calcium concentration of the Barnacle (Balanus nubilus) giant muscle fibre, by direct action on the sercoplasmic reticulum. This inhibitory effect subsequently reduces the 45Ca efflux out of the cell although the 45Ca influx remains unchanged.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002118:Calcium / Q000378:metabolism*; D002132:Calcium Radioisotopes; D002413:Cations, Divalent; D003445:Crustacea; D003600:Cytosol / Q000378:metabolism*; D003620:Dantrolene / Q000494:pharmacology*; D006827:Hydantoins / Q000494:pharmacology*; D009132:Muscles / Q000187:drug effects / Q000378:metabolism*; D012519:Sarcoplasmic Reticulum / Q000187:drug effects*
D002132:Calcium Radioisotopes; D002413:Cations, Divalent; D006827:Hydantoins; D003620:Dantrolene; D002118:Calcium
Régulation du calcium ionisé dans le cytosol de la cellule musculaire au repos: action du "dantrolène" au niveau du réticulum sarcoplasmique