Hyperphenylalanemia: effect on brain polyribosomes can be partially reversed by other amino acids.
The effect of a single injection of phenylalanine (2 mg/g of body weight) on brain polyribosomes, which increases the number of inactive monoribosomes, persists for 2 to 3 hours. A single injection of seven large neutral amino acids after phenylalanine administration results in a reversal of the effect on brain polyribosomes with a resultant decrease in monoribosomes to near normal levels. The other common amino acids are apparently not limiting during hyperphenylalanemia, because an injection of these did not increase recovery.
D000596:Amino Acids / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism*; D010649:Phenylalanine / Q000097:blood / Q000494:pharmacology*; D012270:Ribosomes / Q000378:metabolism*
D000596:Amino Acids; D010649:Phenylalanine