[Carcinogenic effect of 7,12-dimethylbenz(a)anthracene 5,6-oxide in mice].
The comparative carcinogenic activities of 7,12-dimethylbenz(a)anthracene 5,6-oxide (DMBA-5,6-oxide) and 7,12-dimethylbenz(a)anthracene (DMBA) to skin and subcutaneous tissue were studied. It was found that DMBA-5,6-oxide was less carcinogenic to both the skin and subcutaneous tissue, than DMBA. Moreover it does not show any significant initiating acitivity. The results are discussed.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000287:Administration, Topical; D000818:Animals; D001551:Benz(a)Anthracenes / Q000031:analogs & derivatives* / Q000494:pharmacology*; D002273:Carcinogens / Q000494:pharmacology; D002471:Cell Transformation, Neoplastic; D004852:Epoxy Compounds / Q000494:pharmacology; D005260:Female; D005354:Fibrosarcoma / Q000139:chemically induced; D006391:Hemangioma / Q000139:chemically induced; D007279:Injections, Subcutaneous; D008297:Male; D010017:Osteoma, Osteoid / Q000139:chemically induced; D010212:Papilloma / Q000139:chemically induced*; D012867:Skin / Q000187:drug effects; D012878:Skin Neoplasms / Q000139:chemically induced*
D001551:Benz(a)Anthracenes; D002273:Carcinogens; D004852:Epoxy Compounds; D015127:9,10-Dimethyl-1,2-benzanthracene
Action concérogène du 7,12-dimethylbenz(a)anthracène 5,6-oxyde chez la Souris