title: Multiple halo neurofibromas.
abstract: The second case of multiple halo neurofibromatosis is reported. Halo neurofibromas are rare benign tumors that appear on the neck and trunk of adults. The clinical and histopathological differential diagnosis of the other neuroectodermally derived halo lesions, such as neural nevus, nevocellular nevus, spindle and epitheloid cell nevus, blue nevus, and malignant melanoma, also is considered. An autoimmune hypothesis is proposed to explain the depigmentation in the halo neurofibroma. The fact that the patient has café au lait spots that contain giant pigment granules probably indicates that he also has neurofibromatosis.
mesh_terms: D001706:Biopsy; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D008544:Melanocytes / Q000648:ultrastructure; D008875:Middle Aged; D009456:Neurofibromatosis 1 / Q000473:pathology*; D010859:Pigmentation Disorders / Q000473:pathology; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology*