The comparative metabolism of zolazepam in rat, dog and monkey.
The metabolic disposition.of zolazepam, a pyrazolodiazepinone, was studied in male and female Spartan rats, Beagle dogs and Rhesus monkeys. Six principal urinary metabolites were characterized by gas chromatography and combined gas chromatography-mass spectrometry. The major metabolite in male and female rats was produced by N-demethylation and hydroxylation. In addition, female rats, but not the male demethylated zolazepam at the 1-position. Male and female dogs also demethylated zolazepam in the 1-position and hydroxylated in a position other than C-6, producing a metabolite peculiar to the dog. In marked contrast, the major metabolite in the monkey involved demethylation without subsequent hydroxylation.
D000818:Animals; D001381:Azepines / Q000378:metabolism* / Q000652:urine; D002849:Chromatography, Gas; D004285:Dogs; D005260:Female; D005464:Fluorobenzenes / Q000378:metabolism / Q000652:urine; D000882:Haplorhini; D008253:Macaca mulatta; D008297:Male; D013058:Mass Spectrometry; D011720:Pyrazoles / Q000378:metabolism / Q000652:urine; D051381:Rats; D012737:Sex Factors; D013045:Species Specificity; D014149:Tranquilizing Agents / Q000378:metabolism* / Q000652:urine
D001381:Azepines; D005464:Fluorobenzenes; D011720:Pyrazoles; D014149:Tranquilizing Agents