Synthesis of 3-aryl-2-thiohydantoin- and 3-arylhydantoin-5-acetic acids and screening of some of their pharmacological properties.
Seven 3-aryl-2-thiohydantoin-5-acetic acids were obtained from asparagine and arylisothiocyanates. After desulphuration of these compounds by monochloroacetic acid seven 3-arylhydantoin-5-acetic acids were obtained. The structure of these compounds was confirmed by their IR spectra. None of the compounds neither showed the anticonvulsive activity in the electroconvulsions and pentylenetetrazole tests nor inhibited the prostaglandin synthetase.
D000818:Animals; D000927:Anticonvulsants; D016861:Cyclooxygenase Inhibitors; D005260:Female; D006827:Hydantoins / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D013867:Thiohydantoins / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity
D000927:Anticonvulsants; D016861:Cyclooxygenase Inhibitors; D006827:Hydantoins; D013867:Thiohydantoins