[The effect of carbocromen on the ST segment of the epicardial electrocardiogram in a model of intermitting myocardial ischemia (author's transl)].
3-(2-Diethylaminoethyl)-4-methyl-7-(carbethoxy-methoxy)-2-oxo-1,2-chromene-hydrochloride (carbocromen, Intensaïn) was studied on a model of a brief intermittent myocardial ischemia in dogs. At doses which did not affect blood pressure and heart rate, carbocromen markedly improved the ischemic reaction as measured by the ST segment of the epicardial ECG. Higher doses--increasing heart rate--did not, however, aggravate ischemic reaction, although as a rule increasing heart rate enhances ischemic reaction. When keeping the heart rate constant by means of a pace maker, carbocromen even at higher dosage caused a clear-cut improvement. In order to exclude any influence of the experimental and time conditions of the model on the results, identical tests were performed with a placebo. The results proved the carbocromen effects to be independent of the model chosen and its duration. The effects of propranolol, nitroglycerin and isoproterenol observed in our experiments are in agreement with the results frequently described in literature. Considering the changes in ST segment of the epicardial ECG a criterion of myocardial injury, our findings permit the statement that carbocromen clearly reduces the negative sequelae of brief intermittent disturbance of coronary blood flow.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002866:Chromonar / Q000494:pharmacology*; D003326:Coronary Circulation / Q000187:drug effects; D003327:Coronary Disease / Q000503:physiopathology*; D003374:Coumarins / Q000494:pharmacology*; D004195:Disease Models, Animal; D004285:Dogs; D004562:Electrocardiography; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006339:Heart Rate / Q000187:drug effects; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D005996:Nitroglycerin / Q000494:pharmacology; D010138:Pacemaker, Artificial; D011433:Propranolol / Q000494:pharmacology
D003374:Coumarins; D011433:Propranolol; D005996:Nitroglycerin; D007545:Isoproterenol; D002866:Chromonar
Die Wirkung von Carbocromen auf die ST-Strecke des epikardialen Elektrokardiogramms im Modell einer intermittierenden myokardialen Ischämie