[Inhibiting effects of protein fractions isolated from the rat liver in compensating hypertrophy after partial hepatectomy].
We have purified from adult rat liver proteic fractions, which inhibit the cellular growth of cell cultures. These fractions, when they are injected into hepatectomised rats, were able to inhibit the entry of hepatic cells into phase S. Therefore we consider that these substances participate actively in homeostatic control in adult liver.
D000818:Animals; D002458:Cell Fractionation; D002848:Chromatography, DEAE-Cellulose; D002850:Chromatography, Gel; D004247:DNA / Q000096:biosynthesis; D005246:Feedback; D006498:Hepatectomy; D006984:Hypertrophy; D007930:Leucine / Q000378:metabolism; D008099:Liver / Q000032:analysis / Q000378:metabolism / Q000502:physiology*; D008107:Liver Diseases / Q000378:metabolism; D008115:Liver Regeneration / Q000187:drug effects*; D009963:Orotic Acid / Q000378:metabolism; D011489:Protein Denaturation; D011506:Proteins / Q000302:isolation & purification / Q000494:pharmacology*; D012313:RNA / Q000096:biosynthesis; D051381:Rats; D014020:Tissue Extracts / Q000494:pharmacology; D014357:Trypsin
D011506:Proteins; D014020:Tissue Extracts; D009963:Orotic Acid; D012313:RNA; D004247:DNA; D014357:Trypsin; D007930:Leucine
Activité inhibitrice de fractions protéiques isolées du foie de rat sur l'hypertrophie compensatrice après hépatectomie partielle