Splenic sequestration syndrome at mountain altitudes in sickle/hemoglobin C disease.
The splenic sequestration syndrome was observed in five children with sickle/hemoglobin C (S/C) disease in association with a change in altitude. In four of them, it occurred during or immediately following a trip to mountain altitudes greater than 9,000 feet. In the fifth child, the crisis occurred in ten days after travel in a pressurized plane from sea level to Denver. No previous reports of this complication in S/C patients during mountain travel have been noted although the occurrence is known in association with aircraft flights.
D000005:Abdomen; D000293:Adolescent; D000337:Aerospace Medicine; D000531:Altitude; D000755:Anemia, Sickle Cell / Q000150:complications*; D002648:Child; D005260:Female; D005334:Fever / Q000209:etiology; D006445:Hemoglobin C Disease / Q000150:complications*; D006801:Humans; D008297:Male; D010146:Pain / Q000209:etiology; D013159:Splenic Infarction / Q000209:etiology*