Some pharmacological correlations of hypothermia induced by anticholinesterasics.
The investigations have been performed on Wistar rats intoxicated with paraoxon in toxic sublethal doses. There have been measured the variations of rectal temperature at various time periods following the anticholinesterase agent. The authors established the pharmacodynamic correlations of paraoxon-induced hypothermia with cholinesterase reactivators (toxogonin, isonitrosine), anticholinergic substances (atropine, butylscopolamine), carbamic anticholinesterase (eserine, neoeserine) and chlorpromazine. The efficiency of atropine and cholinesterase reactivators in antagonization of hypothermia induced by organophosphorics on the one hand, and only of atropine against hypothermia induced by carbamates on the other hand allow the hypothesis of a central cholinergic mechanism, predominantly muscarinic, involved in hypothermia induced by anticholinesterasics and of a direct correlation of this mechanism with phosphorylation or carbamylation processes of cerebral cholinesterases.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001833:Body Temperature Regulation / Q000187:drug effects; D001921:Brain / Q000201:enzymology; D002086:Butylscopolammonium Bromide / Q000494:pharmacology; D002746:Chlorpromazine / Q000494:pharmacology; D002800:Cholinesterase Inhibitors; D002801:Cholinesterase Reactivators / Q000494:pharmacology; D002802:Cholinesterases / Q000378:metabolism; D005260:Female; D007035:Hypothermia / Q000139:chemically induced*; D010261:Paraoxon; D010275:Parasympathetic Nervous System / Q000187:drug effects; D010830:Physostigmine / Q000494:pharmacology; D051381:Rats
D002800:Cholinesterase Inhibitors; D002801:Cholinesterase Reactivators; D002086:Butylscopolammonium Bromide; D001285:Atropine; D010830:Physostigmine; D002802:Cholinesterases; D010261:Paraoxon; D002746:Chlorpromazine