title: Low serum thyroxine in phenothiazine-treated psychiatric patients.
abstract: Five patients treated with phenothiazines for serious psychiatric disease had markedly depressed serum thyroxine concentrations. There were no clinical or other laboratory findings to suggest hypothyroidism. Additional studies revealed normal levels of thyroxine-binding globulin as assessed by triiodothyronine resin uptake, thyroid-binding globulin capacity, and free thyroxine concentration. In contrast to the low serum thyroxine, serum triiodothyronine concentration was nornal.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001667:Binding, Competitive; D002845:Chromatography; D005260:Female; D006801:Humans; D007456:Iodine Isotopes; D007457:Iodine Radioisotopes; D007475:Ion Exchange Resins; D008297:Male; D008875:Middle Aged; D010640:Phenothiazines / Q000009:adverse effects* / Q000627:therapeutic use; D011485:Protein Binding; D011618:Psychotic Disorders / Q000188:drug therapy; D011863:Radioimmunoassay; D012712:Serum Globulins / Q000032:analysis; D013960:Thyroid Function Tests; D013974:Thyroxine / Q000097:blood / Q000172:deficiency*; D013975:Thyroxine-Binding Proteins / Q000032:analysis; D014284:Triiodothyronine / Q000097:blood
chemical_list: D007456:Iodine Isotopes; D007457:Iodine Radioisotopes; D007475:Ion Exchange Resins; D010640:Phenothiazines; D012712:Serum Globulins; D013975:Thyroxine-Binding Proteins; D014284:Triiodothyronine; D013974:Thyroxine