[Induction of rat hepatic mono-oxygenases by ellipticine: formation of cytochrome p448. Hydroxylating activity].
Ellipticine is able to induce cytochrome P448 synthesis in Rat liver microsomes which converts the drug into 9-hydroxy derivative, with a higher rate than microsomal cytochrome P450 of non-treated or phenobarbital induced Rats. In vivo, ellipticine is also transformed into a second hydroxylated product on the indole aromatic ring.
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis; D003580:Cytochromes / Q000096:biosynthesis*; D004611:Ellipticines / Q000494:pharmacology*; D004790:Enzyme Induction; D006900:Hydroxylation; D008862:Microsomes, Liver / Q000187:drug effects*; D006899:Mixed Function Oxygenases / Q000096:biosynthesis*; D051381:Rats
D000470:Alkaloids; D003580:Cytochromes; D004611:Ellipticines; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases
Induction des mono-oxygénases hépatiques par l'ellipticine chez le Rat: Formation de cytochrome P448. Activité hydroxylante