[Studies on the effectiveness of the anti-D-prevention at the Göttingen University Gynecological Clinic from 1969 to 1972].
The effectivity of the anti-D-prophylaxis performed at the Women's Hospital of the University of Göttingen was controlled by means of serological control examinations of those women, who represented an increase immunological risk of a potential formation of antibodies by means of a second and third Rh-positive infant. None of these women showed an anti-D-body-formation in spite of the application of very sensitive serological methods of examination. In about 10% of our examined women the standard dosis of 300 mug anti-D-IgG had to be increased, so as to achieve a complete elimination of fetal erythrocytes. This result underlines again the necessity of a careful control of influx of red blood corpuscles after the application of anti-D-IgG, so as to avoid failures of the applied prophylaxis. Though we are not in the position to give a final answer concerning the effectivity of our anti-D-prophylaxis with the control examination of 58 serologically observed women, we are of the opinion, that the special immunological stress of a second or third delivery in this special group of patients puts more weight to the observation. As there were no "failures" in these exposed patients to be found by means of the differentiated serological tests during the control examinations, we believe, that our anti-D-prophylaxis-scheme appears to be effective from the present point of view.
D000888:Antibodies, Anti-Idiotypic / Q000008:administration & dosage*; D000918:Antibody Specificity; D004899:Erythroblastosis, Fetal / Q000517:prevention & control*; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D005860:Germany, West; D006782:Hospitals, Special; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007167:Immunotherapy; D011247:Pregnancy; D012204:Rh-Hr Blood-Group System / Q000032:analysis; D012698:Serologic Tests
D000888:Antibodies, Anti-Idiotypic; D007074:Immunoglobulin G; D012204:Rh-Hr Blood-Group System
Untersuchungen zur Effektivität der Anti-D-Prophylaxe der Universitäts-Frauenklinik Göttingen von 1969 bis 1972