New assay of protective activity of Rocky Mountain spotted fever vaccines.
Areas under the fever curves of guinea pigs inoculated with Rocky Mountain spotted fever vaccine over a restricted dose range and infected with a standardized dose of Rickettsia rickettsii varied linearly with log10 dose of vaccine. A calculator was programmed to plot fever curves and calculate the vaccine dose that reduced the fever of infected animals by 50%.
D000818:Animals; D001831:Body Temperature; D004353:Drug Evaluation, Preclinical; D006168:Guinea Pigs; D007274:Injections, Intraperitoneal; D008297:Male; D012284:Rickettsia rickettsii / Q000276:immunology*; D012290:Rickettsial Vaccines / Q000008:administration & dosage*; D012373:Rocky Mountain Spotted Fever / Q000517:prevention & control*; D014612:Vaccines / Q000008:administration & dosage*
D012290:Rickettsial Vaccines; D014612:Vaccines