The local antinociceptive and topical anti-inflammatory effects of propyl gallate in rodents.
1 In common with several anti-inflammatory, analgesic, local anaesthetic and antioxidant drugs, propyl gallate in vitro inhibited the biosynthesis of prostaglandin E2 and F2alpha from arachidonic acid by a prostaglandin synthetase from bull seminal vesicles. 2 In common with analgesic drugs, propyl gallate reduced the ability of arachidonic acid, acetylcholine or acetic acid to cause abdominal constriction in mice. 3 Using a new method for evaluating anti-inflammatory activity, we demonstrated the effectiveness of aspirin or indomethacin given subcuteneously before u.v. irradiation of guinea-pig ears, the prophylactic action of topically applied sunscreen agents and the therapeutic value of bufexamac and propyl gallate applied after irradiation.
D000005:Abdomen / Q000187:drug effects; D000085:Acetates / Q000037:antagonists & inhibitors; D000109:Acetylcholine / Q000037:antagonists & inhibitors; D000287:Administration, Topical; D000700:Analgesics; D000818:Animals; D000893:Anti-Inflammatory Agents; D001095:Arachidonic Acids / Q000037:antagonists & inhibitors; D001241:Aspirin / Q000494:pharmacology; D002417:Cattle; D016861:Cyclooxygenase Inhibitors; D003864:Depression, Chemical; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D011435:Propyl Gallate / Q000494:pharmacology; D011453:Prostaglandins / Q000096:biosynthesis; D012867:Skin / Q000187:drug effects / Q000528:radiation effects; D014466:Ultraviolet Rays
D000085:Acetates; D000700:Analgesics; D000893:Anti-Inflammatory Agents; D001095:Arachidonic Acids; D016861:Cyclooxygenase Inhibitors; D011453:Prostaglandins; D011435:Propyl Gallate; D000109:Acetylcholine; D001241:Aspirin