[Treatment with antidotes in sheep perorally intoxicated].
In a model of sheep perorally intoxicated with a 200.0 mg kg-1 trichlorphon dose, the effectivity of the worked out therapeutical procedure was confirmed; the procedure consisted in the administration of an anticholinergic (20.0 mg of 1.1% atropine s. c. pro toto) and cholinesterase reactivator (30.0 mg of 10% trimedoxime kg-1 i. m.) mixture 4 hours after the administration of the noxious agent. A determination of the erythrocytic acetylcholinesterase (AChE, E.C.3.1.1.7.) and plasmatic butyrylcholinesterase (BChE, E.C.3.1.1.8.) activities in the intoxicated sheep should be considered a decisive clinical and diagnostical test for taking veterinary-therapeutical, veterinary-hygienical or veterinary-sanitary measures in intoxications with anti-cholinesterase substances on the whole.
D000110:Acetylcholinesterase / Q000097:blood; D000818:Animals; D000931:Antidotes / Q000627:therapeutic use*; D001285:Atropine / Q000627:therapeutic use; D002091:Butyrylcholinesterase / Q000097:blood; D011041:Poisoning / Q000188:drug therapy / Q000662:veterinary*; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy* / Q000201:enzymology; D014236:Trichlorfon / Q000506:poisoning*; D014289:Trimedoxime / Q000627:therapeutic use
D000931:Antidotes; D014289:Trimedoxime; D001285:Atropine; D014236:Trichlorfon; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase
Antidotní terapie u ovcí intoxikovaných per os trichlórfonem