DNA-attacking ability of carcinogenic mycotoxins in recombination-deficient mutant cells of Bacillus subtilis.
Thirty mycotoxins and 5 chemically modified toxins were tested for DNA-attacking ability in the rec assay using the recombination-deficient mutant of Bacillus subtilis M45 (rec-) and the parent strain H17 (rec+). Six Penicillium toxins (citrinin, penicillic acid, patulin, (-)-luteoskyrin, (+)-rugulosin, and PR-toxin), 5 Aspergillus toxins (aflatoxins B1 and G1, sterigmatocystin, O-acetylsterigmatocystin, and O-acetyldihydrosterigmatocystin), and 2 Fusarium toxins (zearalenone and zearalenol-b) were positive. Among these 13 compounds, the following 8 mycotoxins have been reported to be carcinogenic in animals: citrinin, penicillic acid, patulin, (-)-luteoskyrin, (+)-rugulosin, aflatoxins B1, and G1, sterigmatocystin. Correlation between the rec effect and in vivo carcinogenicity of mycotoxins is discussed.
D000348:Aflatoxins / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects*; D002273:Carcinogens / Q000494:pharmacology*; D002953:Citrinin / Q000494:pharmacology; D003572:Cytochalasins / Q000494:pharmacology; D004269:DNA, Bacterial; D004305:Dose-Response Relationship, Drug; D004642:Emodin / Q000494:pharmacology; D005669:Fusaric Acid; D006118:Griseofulvin / Q000494:pharmacology; D008990:Moniliformis; D009154:Mutation; D009173:Mycophenolic Acid / Q000494:pharmacology; D009183:Mycotoxins / Q000494:pharmacology*; D009285:Naphthoquinones / Q000494:pharmacology; D009793:Ochratoxins / Q000494:pharmacology; D010365:Patulin / Q000494:pharmacology; D010398:Penicillic Acid / Q000494:pharmacology; D011995:Recombination, Genetic / Q000187:drug effects*; D013241:Sterigmatocystin / Q000494:pharmacology; D013329:Structure-Activity Relationship; D015025:Zearalenone / Q000494:pharmacology
D000348:Aflatoxins; D002273:Carcinogens; D003572:Cytochalasins; D004269:DNA, Bacterial; D009183:Mycotoxins; D009285:Naphthoquinones; D009793:Ochratoxins; D013241:Sterigmatocystin; D006118:Griseofulvin; D002953:Citrinin; D015025:Zearalenone; D010365:Patulin; D009173:Mycophenolic Acid; D005669:Fusaric Acid; D004642:Emodin; D010398:Penicillic Acid