Antitumor activity of paramylon on sarcoma-180 in mice.
The antitumor effect of reserve polysaccharide, paramylon, from Euglena gracilis on the transplantable sarcoma-180 was examined in mice. This polysaccharide had an effect similar to that of lentinan. Paramylon, in a dose of 1 mug/g body weight, injected intraperitoneally 24 hr after tumor implantation had an inhibitory effect on the tumor growth, although without causing complete regression of the tumor. Alkaline-treated paramylon had a similar effect but at a smaller concentration than the native one. The inhibitory activity was not lost when the paramylon preparation was treated with pronase, DNase, or RNase. The antitumor effect might be a lymphocyte-mediated process. In tumors that were regressing after treatment, there was extensive outpouring of lymphoid cells with plasma cells and macrophages. A test conducted using paramylon ruled out the possibility of an interferon-mediated inhibiotry effect on tumor growth.
D000818:Animals; D000970:Antineoplastic Agents; D002642:Chick Embryo; D005056:Euglena gracilis; D005936:Glucans; D007912:Lentinan / Q000627:therapeutic use; D051379:Mice; D011134:Polysaccharides / Q000627:therapeutic use*; D012510:Sarcoma 180 / Q000188:drug therapy* / Q000473:pathology; D013997:Time Factors
D000970:Antineoplastic Agents; D005936:Glucans; D011134:Polysaccharides; D007912:Lentinan; C003045:paramylon