Noradrenergic feeding system in monkey hypothalamus is altered by localized perfusion of glucose, insulin, 2-DG and eating.
Hypothalamic sites in the monkey were labelled by micro-injections of 3H-NE and successive push-pull perfusions were carried out at a rate of 25 mul/min. When the monkey was fed, 3H-NE within the perifornical region increased. When 2-deoxy-D-glucose (2-DG) was added to the perfusate, 3H-NE release was also enhanced, whereas insulin perfused at the same rate caused a delated increase in catecholamine levels as reflected by increased radioactivity. Glucose supressed the release of 3H-NE, suggesting overall that the noradrenergic feeding system in the hypothalamus of the monkey is modulated by the regional level of glucose as well as the local concentration of insulin.
D000818:Animals; D003837:Deoxy Sugars / Q000494:pharmacology*; D003847:Deoxyglucose / Q000008:administration & dosage / Q000494:pharmacology*; D004435:Eating; D005247:Feeding Behavior / Q000187:drug effects*; D005947:Glucose / Q000008:administration & dosage / Q000494:pharmacology*; D000882:Haplorhini; D007031:Hypothalamus / Q000187:drug effects / Q000502:physiology*; D007267:Injections; D007328:Insulin / Q000008:administration & dosage / Q000494:pharmacology*; D009638:Norepinephrine / Q000502:physiology*
D003837:Deoxy Sugars; D007328:Insulin; D003847:Deoxyglucose; D005947:Glucose; D009638:Norepinephrine