Cortisone-resistant effector T cells in acute lymphocytic choriomeningitis and Listeria monocytogenes infection of mice.
Sensitized T cells in both lymphocytic choriomeningitis (LCM) and listeriosis are apparently unaffected by treatment of mice with cortisone acetate. Cortisone-resistant immune T cells readily transfer acute, fatal LCM or protection against L. monocytogenes infection. Treatment of recipient mice with cortisone, however, impairs T cell-dependent effector mechanisms (i.e. macrophages) in listeriosis, but has no effect on induction of LCM. Acute LCM may thus represent a T cell-mediated pathological process which does not require participation of macrophages.
D000208:Acute Disease; D000818:Animals; D003348:Cortisone / Q000494:pharmacology*; D004351:Drug Resistance; D007111:Immunity, Cellular; D007116:Immunization, Passive; D008089:Listeria monocytogenes; D008088:Listeriosis / Q000276:immunology*; D008216:Lymphocytic Choriomeningitis / Q000276:immunology*; D051379:Mice; D008808:Mice, Inbred CBA; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects*
D003348:Cortisone