The metabolic fate of endrin in the rabbit.
1. [14C]Endrin, administered orally to rabbits, is excreted in the faeces as unchanged endrin (50% of that administered) and in the urine as a mixture of polar metabolites. 2. The major biotransformation is hydroxylation at the methylene bridge (C-12) to yield anti-12-hydroxyendrin. syn-Hydroxylation at C-12 also occurs. 3. The hydroxylated metabolites are excreted mainly as their sulphate conjugates. 4. Glucuronide conjugates are also excreted. anti-12-Hydroxyendrin is rapidly conjugated in vitro on incubation with rabbit liver microsomal glucuronyl transferase and UDPGA. 5. Comparative aspects of the metabolism of endrin in rats and rabbits are discussed.
D000284:Administration, Oral; D000818:Animals; D001711:Biotransformation; D004732:Endrin / Q000008:administration & dosage / Q000378:metabolism* / Q000652:urine; D005243:Feces / Q000032:analysis; D005965:Glucuronates / Q000378:metabolism; D014453:Glucuronosyltransferase / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology; D011817:Rabbits; D051381:Rats; D013045:Species Specificity
D005965:Glucuronates; D014453:Glucuronosyltransferase; D004732:Endrin