[Histochemical demonstration of a zinc activated tartrate resistant acid phosphatase in experimentally induced glial microtumors of the rat brain (author's transl)].
The tartrat resistant zinc activated acid phosphatase (ZT-AP) was investigated in 17 glial microtumours of the rat brain. The tumours were induced by N-ethyl-N-nitrosourea injected to newborn rats subcutaneously (85 mg/kg body weight). The morphology of these microtumours corresponds to the statements in the literature. In regard to their behaviour of the investigated enzyme the microtumours may be divided in 2 groups: 1) Microtumours with an activity of acid phosphatases but without any histochemically demonstrable activity of ZT-AP. Histologically they correspond to oligodendric microgliomas. 2) Microtumours with a high activity of acid phosphatases and a remarkable activity of ZT-AP especially in the perivascular cell proliferations. This type corresponds histologically to the astrocytic and mixed glial proliferations including glioblastomas. According to our present findings the ZT-AP was found in astrocytes and especially in mesenchymal cells. In some cases a focal increased activity of ZT-AP could also be observed before histological alterations appeared. We regard it as an early stage of the development of tumours.
D000135:Acid Phosphatase / Q000032:analysis*; D000818:Animals; D001254:Astrocytoma / Q000139:chemically induced / Q000201:enzymology* / Q000473:pathology; D001932:Brain Neoplasms / Q000139:chemically induced / Q000201:enzymology* / Q000473:pathology; D005038:Ethylnitrosourea / Q000494:pharmacology; D005260:Female; D006651:Histocytochemistry; D008297:Male; D009837:Oligodendroglioma / Q000139:chemically induced / Q000201:enzymology* / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D013268:Stimulation, Chemical; D013644:Tartrates / Q000494:pharmacology; D015032:Zinc / Q000494:pharmacology
D013644:Tartrates; D000135:Acid Phosphatase; D015032:Zinc; D005038:Ethylnitrosourea
Histochemische Darstellung einer durch Zink aktivierten tartrat-resistenten sauren Phosphatase in experimentell induzierten gliösen Mikrotumoren des Rattengrosshirns