title: [Study of the decomposition of alkylating mutagens of the ethyleneimine series in human lymphocyte cultures].
abstract: A simple method of determination (with a high reproducibility) of concentrations of the alkylating compound in the culture medium is described. Thiophosphamide failed to decompose in the course of 24 hours either in the culture mixture or in the human lymphocyte culture. As to phosphamide, dipine and fotrin, these drugs disintegrated significantly in the culture during 24 hours, but not in the course of the first 6 hours.
mesh_terms: D000477:Alkylating Agents / Q000378:metabolism*; D000970:Antineoplastic Agents / Q000378:metabolism; D001388:Aziridines; D001389:Azirines / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D007306:Insecticides / Q000378:metabolism; D008214:Lymphocytes / Q000378:metabolism*; D009153:Mutagens / Q000032:analysis*; D009943:Organophosphorus Compounds / Q000378:metabolism*; D010720:Phosphines / Q000378:metabolism; D013852:Thiotepa / Q000378:metabolism
chemical_list: D000477:Alkylating Agents; D000970:Antineoplastic Agents; D001388:Aziridines; D001389:Azirines; D007306:Insecticides; D009153:Mutagens; D009943:Organophosphorus Compounds; D010720:Phosphines; C007779:fotrin; D013852:Thiotepa
vernacular_title: Issledovanie razlozheniia alkiliruiushchikh mutagenov étileniminovogo riada v kul'ture limfotsitov cheloveka