Massive splenomegaly, pancytopenia and haemolytic anaemia in sarcoidosis.
A 53-year-old dock labourer, presented with massive splenomegaly and subsequently developed pancytopenia. Complete haematoglogical remission was observed following splenectomy. Histological examination of the liver and spleen revealed sarcoid granulomata. A year after splenectomy, he died in an acute haemolytic crisis, a very rare complication of sarcoidosis. Evidence of generalized sarcoidosis was found at autopsy. The literature on haematological complications in sarcoidosis is reviewed.
D000741:Anemia, Aplastic / Q000209:etiology*; D000743:Anemia, Hemolytic / Q000209:etiology*; D001344:Autopsy; D006801:Humans; D008099:Liver / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012507:Sarcoidosis / Q000150:complications* / Q000473:pathology / Q000601:surgery; D013154:Spleen / Q000473:pathology; D013156:Splenectomy; D013163:Splenomegaly / Q000209:etiology*