title: Experimentally induced infectious bovine keratoconjunctivitis: relationship of vaccination schedule to protection against exposure with homologous Moraxella bovis culture.
abstract: Calves were intramuscularly vaccinated with a formalin-killed Moraxella bovis culture. They were given 3 doses of the vaccinal culture at 3 different intervals between injections, as follows: 7-day intervals (group I), 14-day intervals (group II), an21-day intervals (group III); 14 days after the 3rd vaccinal dose was given, calves in all groups were challenge exposed to virulent homologous M bovis. The challenge bacterium became established in all (100%) of the control (group IV, N equals 8) and group I (N equals 8) calves, in 7 (87%) of the group II calves (N equals 8), and in 5 (62%) of the group III (N equals 8) calves. Signs of infectious bovine keratoconjunctivitis (IBK) developed in 8 (100%) of the controls, in 6 (75%) of the group I calves, in 1 (12%) of the group II calves, and in 2 (25%) of the group III calves. These results indicate that at least 14 days should be allowed between successive doses of this experimental vaccine.
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000382:microbiology / Q000517:prevention & control / Q000662:veterinary; D001428:Bacterial Vaccines / Q000008:administration & dosage; D002417:Cattle; D002418:Cattle Diseases / Q000382:microbiology / Q000517:prevention & control*; D005123:Eye / Q000382:microbiology / Q000528:radiation effects; D007115:Immunization Schedule / Q000662:veterinary*; D005779:Immunodiffusion; D007273:Injections, Intramuscular; D007637:Keratoconjunctivitis / Q000382:microbiology / Q000517:prevention & control / Q000662:veterinary*; D009016:Moraxella / Q000276:immunology* / Q000302:isolation & purification; D011830:Radiation Effects; D013997:Time Factors; D014466:Ultraviolet Rays; D014611:Vaccination / Q000662:veterinary
chemical_list: D001428:Bacterial Vaccines