title: [Effects of an antiserum prepared against purified protease of pseudomonas aeruginosa (authors transl)].
abstract: Purified protease was obtained from Pseudomonas aeruginosa. It stimulated in rabbits the production of antibodies, which could be demonstrated mainly in an indirect hemagglutination test. Injected intracutaneously into rabbits, the protease caused an increased permeability in the capillaries and in higher doses bleedings. Immunization with the protease reduced the development of these lesions. Similar findings were obtained in experiments with mice. An antiserum prepared in rabbits against purified protease did not protect mice against infection with P. aeruginosa. However, a small protective effect could be observed after active immunization.
mesh_terms: D000818:Animals; D000918:Antibody Specificity; D002199:Capillary Permeability / Q000187:drug effects; D006386:Hemagglutination Tests; D007106:Immune Sera / Q000494:pharmacology*; D007114:Immunization; D007122:Immunoelectrophoresis; D007271:Injections, Intradermal; D051379:Mice; D010447:Peptide Hydrolases / Q000276:immunology* / Q000302:isolation & purification / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000201:enzymology*; D011817:Rabbits / Q000276:immunology
chemical_list: D007106:Immune Sera; D010447:Peptide Hydrolases
vernacular_title: Wirkungen eines gegen gereinigte Protease von Pseudomonas antiserms hergestellten aeruginosa