[Mitomycin and a new phenoxazone pigment from Streptomyces michiganensis. Metabolic products of microorganisms (author's transl)].
Streptomyces michiganensis strain Tü 1074, was isolated from a Tunesian soil sample and produces in liquid medium an antibiotic active pigment complex. Besides mitomycin A the separation of this complex yielded a nonactive phenoxazone, which hitherto has not been described in the literature. In contrary to all known phenoxazones from micro-organisms the new compound lacks a 2-amino-function. The production of this phenoxazone could be enhanced by optimizing the condtions of fermentation.
D000900:Anti-Bacterial Agents / Q000302:isolation & purification*; D001412:Bacillus subtilis / Q000187:drug effects; D003470:Culture Media; D008937:Mitomycins / Q000302:isolation & purification*; D008968:Molecular Conformation; D010078:Oxazines / Q000302:isolation & purification*; D010860:Pigments, Biological / Q000032:analysis* / Q000302:isolation & purification; D012988:Soil Microbiology; D013302:Streptomyces / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D003470:Culture Media; D008937:Mitomycins; D010078:Oxazines; D010860:Pigments, Biological
Mitomycin und ein neues Phenoxazon-Pigment aus Streptomyces michiganensis. Stoffwechselprodukte von Mikroorganismen.