Drug-induced reinstatement of extinguished self-administration behavior in monkeys.
Responding was established in squirrel monkeys under a modified progressive ratio schedule of IV d-amphetamine or cocaine self-administration. Subsituation of saline for the drug solutions resulted in extinction of the self-administration behavior. IV injections of certain doses of d-amphetamine or cocaine, immediately prior to test sessions in which response-contingent saline infusions were delivered, reinstated the rate and pattern of responding observed during sessions in which drug was self-administered. Presession IV injections of several doses of pentobarbital or chlorpromazine failed to consistently reinstate responding. These results were interpreted in terms of the discriminative control of drug self-administration behavior by the current drug state of the subject.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002746:Chlorpromazine / Q000494:pharmacology; D003042:Cocaine / Q000494:pharmacology*; D003913:Dextroamphetamine / Q000494:pharmacology*; D005108:Extinction, Psychological / Q000187:drug effects*; D000882:Haplorhini; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology; D012055:Reinforcement Schedule; D012453:Saimiri; D013997:Time Factors
D010424:Pentobarbital; D003042:Cocaine; D003913:Dextroamphetamine; D002746:Chlorpromazine