Enzymatic modification of aminoglycoside antibiotics: a new 6'-N-acetylating enzyme from a Pseudomonas aeruginosa isolate.
We describe an aminoglycoside 6'-N-acetyltransferase, isolated from Pseudomonas aeruginosa, that exhibits a novel substrate profile characterized by markedly reduced activity towards butirosin and amikacin.
D000123:Acetyltransferases / Q000302:isolation & purification / Q000378:metabolism*; D000617:Aminoglycosides / Q000096:biosynthesis*; D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D003227:Conjugation, Genetic; D004352:Drug Resistance, Microbial; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000201:enzymology*; D012853:Sisomicin / Q000378:metabolism
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000123:Acetyltransferases; D012853:Sisomicin