Metabolism and autoradiographic distribution of delta-8- and delta-9-tetrahydrocannabinol in some organs of the monkey Callithrix jacchus.
Metabolism and autoradiographic distribution of the two isomeric tetrahydrocannabinols, (2,4-14-C)-delta-8-THC and (2,4-14-C)-delta-9-THC, were studied in the marmoset Callithrix jacchus. Of the two cannabinoids, delta-8-THC had a slower initial rate of biotransformation to the psychopharmacologically more potent 11-hydroxylated metabolite. This may explain the minor psychopharmacological activity of the delta-8-isomer. In glandular tissues an accumulation of unchanged delta-9-THC was observed. Autoradiography revealed characteristic label distributions in some organs 30 min after the administration of the drugs. This labelling pattern was found to be changed after a 6-hr incorporation period. The autoradiographic distribution of delta-8 and delta-9-THC appeared to be identical.
D000311:Adrenal Glands / Q000032:analysis; D000818:Animals; D001345:Autoradiography; D001646:Bile / Q000032:analysis; D001711:Biotransformation; D002143:Callitrichinae; D002188:Cannabis / Q000378:metabolism*; D002250:Carbon Radioisotopes; D013759:Dronabinol / Q000097:blood / Q000378:metabolism*; D006900:Hydroxylation; D007536:Isomerism; D007668:Kidney / Q000032:analysis; D008099:Liver / Q000032:analysis; D008168:Lung / Q000032:analysis; D010179:Pancreas / Q000032:analysis; D010306:Parotid Gland / Q000032:analysis; D013270:Stomach / Q000032:analysis
D002250:Carbon Radioisotopes; D013759:Dronabinol