Competence in continuous cultures of Bacillus subtilis: inhibition by arginine and reversal of the inhibition by Mn2+.
Arginine inhibited the competence of Bacillus subtilis growing in a chemostat at a dilution rate of 0-277 h-1. The biosynthesis of competence-stimulating activity was only partially repressed. The inhibitory effect may be due to an alteration in the cell's capacity for being stimulated to competence and/or in its ability to take up DNA irreversibly. MnSO4 at 10(-6) M restored competence immediately.
D001120:Arginine / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000378:metabolism; D004269:DNA, Bacterial / Q000378:metabolism; D008345:Manganese / Q000494:pharmacology*; D014170:Transformation, Genetic
D004269:DNA, Bacterial; D008345:Manganese; D001120:Arginine