Inhibition of prostaglandin activity and synthesis by fenbufen (a new nonsteroidal antiinflammatory agent) and one of its metabolites.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000494:pharmacology*; D002474:Cell-Free System; D016861:Cyclooxygenase Inhibitors; D004158:Diphenylacetic Acids / Q000494:pharmacology*; D006168:Guinea Pigs; D007213:Indomethacin / Q000494:pharmacology; D008168:Lung / Q000201:enzymology; D006899:Mixed Function Oxygenases / Q000037:antagonists & inhibitors*; D009119:Muscle Contraction / Q000187:drug effects; D010654:Phenylbutyrates; D011422:Propionates / Q000494:pharmacology*; D011448:Prostaglandin Antagonists; D012867:Skin / Q000201:enzymology; D013329:Structure-Activity Relationship
D000893:Anti-Inflammatory Agents; D001713:Biphenyl Compounds; D016861:Cyclooxygenase Inhibitors; D004158:Diphenylacetic Acids; D010654:Phenylbutyrates; D011422:Propionates; D011448:Prostaglandin Antagonists; C010725:fenbufen; D006899:Mixed Function Oxygenases; D007213:Indomethacin