[Increase of immune response by administration of metabolizable vegetable oil emulsions].
Though highly efficient, Freund's adjuvant has serious limitations because it contains mineral oil and isomannide monooleate emulsifier (arlacel A). The present study describes the conditions under which a stable water in oil emulsion can be produced by using  metabolizable peanut oil with arlacel. When mycobacteria are added, a potent emulsified oil adjuvant is obtained which increases the immune response to BSA and to influenza vaccine.
D000276:Adjuvants, Immunologic; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D004655:Emulsions; D005260:Female; D005620:Freund's Adjuvant / Q000494:pharmacology; D007252:Influenza Vaccines; D051379:Mice; D009821:Oils / Q000494:pharmacology*; D012710:Serum Albumin, Bovine / Q000276:immunology; D014867:Water
D000276:Adjuvants, Immunologic; D004655:Emulsions; D007252:Influenza Vaccines; D009821:Oils; D014867:Water; D012710:Serum Albumin, Bovine; D005620:Freund's Adjuvant
Augmentation de la réponse immunitaire par administration d'émulsions à base d'huile végétale métabolisable