[The effect of a long-term administration of fluorine with food on the carcinogenesis and biochemical changes in the liver of rats].
The effect of different amounts of fluorine in the ingested food (1.5 and 5 mg per 1 kg of body weight) on the development of tumours and biochemical changes in the liver of rats with carcinogenesis caused by their feeding on DAB was studied. With a long-term administration of fluorine in a dose of 1.5 mg/kg the appearance of macroscopically visible tumours in the liver proved less notable than with a lower dose or complete absence of fluorine. With carcinogenesis the rate of glycolysis in the liver of rats increases. A relationship between the inhibiting action of sodium fluoride on the glycolysis and changed activity of phosphofructokinase has been ascertained.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005459:Fluorides / Q000494:pharmacology*; D006019:Glycolysis / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008113:Liver Neoplasms / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism*; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism; D051381:Rats; D013997:Time Factors; D004124:p-Dimethylaminoazobenzene
D004124:p-Dimethylaminoazobenzene; D005459:Fluorides
Vliianie prodolzhitel'nogo vvedeniia ftora s pishcheĭ na kantserogenez i biokhimicheskie izmeneniia v pecheni krys