title: 5' nucleotidase activity in leukaemic lymphocytes.
abstract: The enzyme 5' nucleotidase (E.C.3.1.3.5.) is present in lymphocytes isolated from the blood of normal subjects. The activity was extremely low in lymphocytes from 17 patients with B lymphocytic leukaemias. Removal of normal lymphocytes from the B-cell leukaemic samples decreased further the enzyme activity. Moderately low values were observed in three cases of T-ALL and in the cells from a case of Sézary syndrome. In contrast, normal or high values were observed in three cases of ALL in which T and B markers were not demonstrable and in two of T-CLL. No differences were observed in partially purified subpopulations of normal B and T cells.
mesh_terms: D001402:B-Lymphocytes / Q000201:enzymology; D002462:Cell Membrane / Q000201:enzymology; D002469:Cell Separation; D006801:Humans; D007938:Leukemia / Q000201:enzymology; D007945:Leukemia, Lymphoid / Q000201:enzymology*; D008206:Lymphatic Diseases / Q000201:enzymology; D008214:Lymphocytes / Q000201:enzymology*; D009708:Nucleotidases / Q000097:blood*; D013601:T-Lymphocytes / Q000201:enzymology; D008258:Waldenstrom Macroglobulinemia / Q000201:enzymology
chemical_list: D009708:Nucleotidases