[Changes of lung function in experimentally induced emphysema before and after unilateral homotransplantation of the canine lung].
Pulmonary function studies after single-lung homotransplantation in dogs with experimentally induced emphysema. Pulmonary emphysema was induced in 8 bastard dogs by intratracheal instillation of papain (dose 2 mg/kg 3 to 5 times in 6 to 10 weeks). Development of emphysema was documented by weekly pulmonary function studies. The emphysematous animals underwent single-lung homotransplantation. Postoperative studies of lung function were performed immediately after transplantation and 1 week postoperatively. Bronchospirometric measurement revealed that ventilatory function and oxygen consumption of the graft was at least equal to the animal's own emphysematous lung. Up to 1 week after transplantation there is no evidence of serious ventilation-perfusion imbalance.
D000818:Animals; D004285:Dogs; D016040:Lung Transplantation; D010101:Oxygen Consumption; D011183:Postoperative Complications / Q000503:physiopathology; D011656:Pulmonary Emphysema / Q000503:physiopathology*; D013147:Spirometry; D013997:Time Factors; D014184:Transplantation, Homologous; D014692:Ventilation-Perfusion Ratio
Veränderungen der Lungenfunktion bei experimentell erzeugtem Emphysem vor und nach einseitiger Lungenhomotransplantation am Hund.