Nephrotoxic effect of parenteral and intraarticular gold. Ultrastructure and electron microprobe examination of clinical and experimental material.
The presence of gold in the kidney of a 58-year-old woman was confirmed by use of ultrastructural and microprobe examinations. A series of animal experiments were performed in which small single doses of gold were administered systemically and intraarticularly in rabbits. Both the colloidal suspension and the soluable salt gold sodium thiomalate (Myochrysine) were used. Selective lesions occurred in the proximal convoluted tubules and the mitochondria appeared to be the target organelle. They contained gold after gold sodium thiomalate but not after colloidal gold.
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D005260:Female; D005921:Glomerulonephritis / Q000139:chemically induced / Q000473:pathology; D006048:Gold Colloid, Radioactive / Q000008:administration & dosage / Q000633:toxicity*; D006052:Gold Sodium Thiomalate / Q000008:administration & dosage / Q000009:adverse effects / Q000633:toxicity*; D006801:Humans; D007270:Injections, Intra-Articular; D007273:Injections, Intramuscular; D007279:Injections, Subcutaneous; D007668:Kidney / Q000187:drug effects* / Q000648:ultrastructure; D007687:Kidney Tubules, Proximal / Q000187:drug effects; D008208:Lymphatic System / Q000187:drug effects; D008247:Lysosomes / Q000648:ultrastructure; D008854:Microscopy, Electron; D008875:Middle Aged; D008928:Mitochondria / Q000187:drug effects / Q000648:ultrastructure; D011817:Rabbits; D013583:Synovial Membrane / Q000473:pathology
D006048:Gold Colloid, Radioactive; D006052:Gold Sodium Thiomalate