The effect of gastric inhibitory polypeptide on human jejunal water and electrolyte transport.
Using a triple-lumen gut perfusion technique, the net flux of water and electrolytes in the jejunum of 5 healthy volunteers was measured before, during and after an intravenous infusion of gastric inhibitory polypeptide (GIP). The dose of GIP used (1 mug/min for 30 mins) has previously been shown to raise serum GIP levels to physiological levels achieved in normal subjects after a meal. During GIP infusion, net water Na, K, and HCO3 absorption was significantly reduced and chloride flux was switched from absorption to secretion when compared to pre- and post-GIP control periods (p less than 0.001).
D000328:Adult; D001692:Biological Transport / Q000187:drug effects; D004573:Electrolytes / Q000378:metabolism*; D005749:Gastric Inhibitory Polypeptide / Q000008:administration & dosage / Q000494:pharmacology*; D005768:Gastrointestinal Hormones / Q000494:pharmacology*; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D007419:Intestinal Secretions / Q000187:drug effects; D007421:Intestine, Small / Q000187:drug effects; D007583:Jejunum / Q000378:metabolism*; D013268:Stimulation, Chemical; D014867:Water / Q000378:metabolism*
D004573:Electrolytes; D005768:Gastrointestinal Hormones; D014867:Water; D005749:Gastric Inhibitory Polypeptide