title: The effect of heavy orthopedic forces on the sutures of the facial bones.
abstract: The effect of heavy continuous orthopedic forces was studied in three Saimiri Sciureus (squirrel) monkeys. Two additional monkeys served as controls. The maxillary sutures were investigated microscopically. In addition, the bone markers (tetracycline, Procion Red H-8 BS) served for quantitative evaluation under ultraviolet light. After two weeks slight remodeling activity could be observed. After one month a tremendous activity was found in the sutures. The width of the sutures was two to three times enlarged. The regular tissue pattern of the sutures had changed to a mixture of precollagen and collagen fibers running in all directions with plenty of active cells. In the ultraviolet light there is a take up of markers at the sutural margins. After three months of treatment though, the sutures showed a similar pattern. The three zones of the sutures began to form again; osteoblasts were attached to the sutural margins and reorganization was relatively complete.
mesh_terms: D000818:Animals; D001808:Blood Vessels; D001846:Bone Development; D001862:Bone Resorption; D003094:Collagen; D004396:Coloring Agents; D003238:Connective Tissue; D005147:Facial Bones / Q000098:blood supply / Q000254:growth & development / Q000502:physiology; D005624:Frontal Bone / Q000502:physiology; D000882:Haplorhini; D008437:Maxilla / Q000502:physiology; D008445:Maxillofacial Development; D009967:Orthodontic Appliances / Q000009:adverse effects*; D009971:Orthodontics, Corrective / Q000009:adverse effects; D010006:Osteoblasts; D010010:Osteoclasts; D010118:Oxytetracycline; D010159:Palate / Q000502:physiology; D010521:Periosteum; D015050:Zygoma / Q000473:pathology
chemical_list: D004396:Coloring Agents; D003094:Collagen; D010118:Oxytetracycline