[The clinical valency of monoclonal immunoglobulins. Attempt at a determination of their importance].
The classification of the protein bodies which Apitz in his time called paraproteins into the large spectre of the immunoglobulins has had a decisive influence on the clinical valency of these findings. Nowadays it is possible to estimate these proteins from the point of view of their development as the functional evidence of a monoclonal proliferation as well as issuing from the part of their immunological effect. 218 cases of monoclonal immunoglobulin are distributed according to the clinical diagnosis. Here it is shown that also a not unconsiderable proportion of benign diseases reveals these findings. Monoclonal immunoglobulins are of special interest when diseases of the group of nosological forms of the lympho-plasma-cellular reticulum and particularly of the paraproteinaemic haemoblastoses are in question. The analysis of the monoclonal macroglobulinaemias has led to a new orientation concerning Waldenstroem's disease which absolutely might be regarded as a nosological entity and no more as a morphological one. A special quality of the protein, the formation of cryoprotein, has close structural relations to the easy chain type kappa, which possibly in general must closely be correlated with reactions of immunoglobulins dependent on temperature.
D001327:Autoimmune Diseases / Q000276:immunology; D006801:Humans; D007145:Immunoglobulin kappa-Chains; D007136:Immunoglobulins; D008214:Lymphocytes / Q000276:immunology; D010950:Plasma Cells / Q000276:immunology; D010954:Plasmacytoma / Q000276:immunology; D012995:Solubility; D013696:Temperature; D008258:Waldenstrom Macroglobulinemia / Q000276:immunology
D007145:Immunoglobulin kappa-Chains; D007136:Immunoglobulins
Zur klinischen Wertigkeit momoklonaler Immunglobuline. Versuch einer Standortbestimmung