Studies on sterol/steroid biosynthesis from 3:4 dihydroxy phenyl alanine.
Homogenated tissue of gonads of Rana tigrina were incubated in Young's Ringer solution containing 5 mg of 3:4 dihydroxy phenylalanine. An increase in the cholesterol and neutral-17-ketosteroids was found when compared with the control. Perfusion of ovary with DOPA gave similar results. However, there was a sharp drop (greater than 50%) in the cholesterol contents of the kidney and suprarenal under similar conditions. A postulated scheme of steroid biosynthesis from DOPA is given.
D015068:17-Ketosteroids / Q000096:biosynthesis*; D000818:Animals; D001001:Anura; D002784:Cholesterol / Q000096:biosynthesis*; D004295:Dihydroxyphenylalanine / Q000378:metabolism*; D005260:Female; D007668:Kidney / Q000378:metabolism; D008297:Male; D010053:Ovary / Q000378:metabolism; D011898:Ranidae; D013737:Testis / Q000378:metabolism
D015068:17-Ketosteroids; D004295:Dihydroxyphenylalanine; D002784:Cholesterol