title: [Investigations on the influence of NO2 and SO2 as well a combination of the two gases on the production of precipitating antibodies in guinea-pigs (author's transl)].
abstract: The influence of NO2 and SO2 or their combination on the production of precipitating antibodies was studied in guinea pigs. The gas concentration has been 10 mg/m3; the continuous exposure began 3 days before sensitization and lasted up to the testing date. Sensitization was done s.c. and i.m. with fresh chicken albumen plus complete Freund's adjuvans. Production of precipitating antibodies was tested by the double diffusion method of Ouchterlony. Moreover total protein content was measured and an immunelectrophoretic separation of the protein fractions was performed with polyvalent antiguinea pig serum. The statistical evaluation of the results has yielded no support in favour of an interaction of NO2 and SO2 or their combination in the concentration used on the formation of precipitating antibodies.
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D001798:Blood Proteins / Q000378:metabolism; D005260:Female; D005620:Freund's Adjuvant; D006168:Guinea Pigs; D005779:Immunodiffusion; D007122:Immunoelectrophoresis; D007273:Injections, Intramuscular; D007279:Injections, Subcutaneous; D009585:Nitrogen Dioxide / Q000494:pharmacology*; D010047:Ovalbumin; D011234:Precipitins / Q000096:biosynthesis*; D013458:Sulfur Dioxide / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D001798:Blood Proteins; D011234:Precipitins; D013458:Sulfur Dioxide; D010047:Ovalbumin; D005620:Freund's Adjuvant; D009585:Nitrogen Dioxide
vernacular_title: Untersuchungen zur Frage des Einflusses von NO2 und SO2 bzw. einer Kombination beider Gase auf die Bildung präzipitierender Antikörper beim Meerschweinchen