Central nervous system effects of hypothalamic peptides.
Intravenous (i.v.) administration of TRF (1 mg/kg) increases the LD50 of pentobarbital (PB) by 25% while the same dose of somatostatin results in a 30% reduction in PB LD50. A similar increase of PB LD50 by TRF was observed in hypophysectomized rats. Mortality was completely abolished in rats receiving TRF (1 mg/kg) ten minutes after a lethal dose of PB (120 mg/kg). Somatostatin (1 mg/kg) decreases strychnine-induced seizure duration and increases strychnine LD50 by 21% while TRF lowers the strychnine LD50  by 28%. These observations are consistent with central nervous system sites of action  for TRF and somatostatin.
D000818:Animals; D002490:Central Nervous System / Q000187:drug effects*; D007016:Hypophysectomy; D007855:Lead Poisoning; D007928:Lethal Dose 50; D008297:Male; D010424:Pentobarbital / Q000633:toxicity; D051381:Rats; D013004:Somatostatin / Q000494:pharmacology*; D013331:Strychnine / Q000633:toxicity; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*
D013004:Somatostatin; D013973:Thyrotropin-Releasing Hormone; D013331:Strychnine; D010424:Pentobarbital