Effect of thyroid status on the thyrotrophin-releasing hormone-degrading activity of rat serum.
The TRH-degrading activity of rat serum in vitro is five times more potent than that of human serum. In rats, it is significantly reduced in hypothyroidism (thiouracil-induced) and significantly increased in hyperthyroidism (T3 or T4-induced). This suggests a possible role in the regulation of adenohypophysial-thyroid function which is probably, in turn, dependent on thyroid hormone, rather than TSH, levels.
D000818:Animals; D003080:Cold Temperature; D004789:Enzyme Activation; D005260:Female; D006980:Hyperthyroidism / Q000201:enzymology; D007031:Hypothalamus / Q000502:physiology; D007037:Hypothyroidism / Q000139:chemically induced / Q000201:enzymology; D008297:Male; D010447:Peptide Hydrolases / Q000097:blood*; D010903:Pituitary Gland, Anterior / Q000502:physiology; D051381:Rats; D013889:Thiouracil; D013961:Thyroid Gland / Q000502:physiology*; D013963:Thyroid Hormones / Q000502:physiology; D013973:Thyrotropin-Releasing Hormone / Q000097:blood / Q000378:metabolism*
D013963:Thyroid Hormones; D013889:Thiouracil; D013973:Thyrotropin-Releasing Hormone; D010447:Peptide Hydrolases