[Effect of glucose and phenobarbital on the concentration of 11-hydroxycorticosteroids in the blood plasma of piglets].
In piglets 18 to 30 days old, the authors studied the changes of the levels of plasmatic 11-hydroxycorticosteroids (11-OHCS), the overall content of cholesterol and blood glucose two hours after oral application of glucose or phenobarbital. A dose of 0.5 g of glucose per kg of weight did not affect the parameters in question as compared with the control group which received a physiological solution. A dose of 2 g of glucose per kg of bodyweight caused glycaemia two hours after administration and an non-significant increase of the 11-OHCS level. Phenobarbital, administered at the rate of 10 mg per kg of bodyweight, markedly reduced the 11-OHCS level in the blood plasma. The level of total cholesterol showed a slight decrease in all instances. The authors discuss the mechanisms causing the changes observed. It is suggested that the effect of phenobarbital could be used for moderating the negative effects of the raised glucocorticoid level in stress situations.
D015062:11-Hydroxycorticosteroids / Q000097:blood*; D000284:Administration, Oral; D000818:Animals; D002784:Cholesterol / Q000097:blood; D005947:Glucose / Q000008:administration & dosage / Q000494:pharmacology*; D010634:Phenobarbital / Q000008:administration & dosage / Q000494:pharmacology*; D013312:Stress, Physiological / Q000097:blood; D013552:Swine / Q000378:metabolism*
D015062:11-Hydroxycorticosteroids; D002784:Cholesterol; D005947:Glucose; D010634:Phenobarbital
Ucinek glukózy a fenobarbitalu na koncentraci 11-hydroxykortikosteroidü v krevní plazmĕ selat