[Inhibition of bacterial neuraminidases by different anions (author's transl)].
It was shown that neuraminidase of Vibrio comma is inactivated by Ca..-binding anions like citrate, EDTA, oxalate, phosphate or tartrate. There is, however, no inhibition of the newly described enzymes of Erysipelothrix insidiosa and Streptococcus viridans. Pyruvate and, to a lesser extent, also citrate inactivate all the neuraminidases investigated independently of their activation by Ca..ions.
D001205:Ascorbic Acid / Q000494:pharmacology; D001419:Bacteria / Q000201:enzymology*; D002118:Calcium / Q000378:metabolism; D002951:Citrates / Q000494:pharmacology; D004492:Edetic Acid / Q000494:pharmacology; D004888:Erysipelothrix / Q000201:enzymology; D009439:Neuraminidase / Q000037:antagonists & inhibitors*; D010070:Oxalates / Q000494:pharmacology; D010325:Pasteurella / Q000201:enzymology; D010710:Phosphates / Q000494:pharmacology; D011773:Pyruvates / Q000494:pharmacology; D013291:Streptococcus / Q000201:enzymology; D013644:Tartrates / Q000494:pharmacology; D014734:Vibrio cholerae / Q000201:enzymology
D002951:Citrates; D010070:Oxalates; D010710:Phosphates; D011773:Pyruvates; D013644:Tartrates; D004492:Edetic Acid; D009439:Neuraminidase; D001205:Ascorbic Acid; D002118:Calcium
Uber die Hemmung bakterieller Neuraminidasen durch verschiedene Anionen