Comparative in vitro activity of Sch 20656, netilmicin, gentamicin, and tobramycin.
Sch 20656 and netilmicin (Sch 20569), two new semisynthetic aminoglycosides, were as active as gentamicin and tobramycin against Enterobacteriaceae. Against Pseudomonas aeruginosa, Sch 20656 was the least active, whereas netilmicin was active against many highly gentamicin-resistant isolates.
D000617:Aminoglycosides / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004755:Enterobacteriaceae / Q000187:drug effects*; D005839:Gentamicins / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D012853:Sisomicin / Q000031:analogs & derivatives* / Q000494:pharmacology; D014031:Tobramycin / Q000494:pharmacology*
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D005839:Gentamicins; D014031:Tobramycin; D012853:Sisomicin