Thrombopoietin activity in mice following immune-induced thrombocytopenia.
Thrombopoietin levels in thrombocytopenic mice assayed by 75Se-se-lenomethionine incorporation into blood platelets reached a maximum 12 h after the induction of an acute, immune thrombocytopenia; that was more than twice the value in control mice. The implications of this finding are discussed with reference to the kinetics of megakaryocyte production.
D000208:Acute Disease; D000818:Animals; D001792:Blood Platelets / Q000276:immunology; D006023:Glycoproteins / Q000378:metabolism*; D008297:Male; D051379:Mice; D013921:Thrombocytopenia / Q000097:blood / Q000209:etiology / Q000276:immunology*; D013926:Thrombopoietin / Q000378:metabolism*
D006023:Glycoproteins; D013926:Thrombopoietin