title: Chronic oral exposure of rainbow trout (Salmo gairdneri) to a polychlorinated biphenyl (Aroclor 1254): pathological effects.
abstract: Groups of eight rainbow trout (Salmo gairdneri) were fed rations containing 0 ppm, 1 ppm, 10 ppm and 100 ppm of the polychlorinated biphenyl, Aroclor 1254, over a period of up to 330 days. Growth rates were unaffected by these levels. Pathological changes were found in the kidneys of 13 fish on the polychlorinated biphenyl ration. Foci of nephrosis with cellular or granular cast formation were seen. The greatest number of cases occured in fish at the 10 ppm concentration. An increase in the number of hepatocytes per unit area was related to the greater concentration of polychlorinated biphenyls in the diet. A reduction in the amount of white pulp in the spleen was observed in 23 of 27 fish on the 10 ppm and 100 ppm diets. The fish with nephrosis had reduced splenic white pulp and lowered white cell counts. Fish fed the 1 ppm and 10 ppm levels had mean tissue residues of 1.4 and 2.3 ppm polychlorinated biphenyl respectively. Fish on the 100 ppm ration had a mean value of 80.1 ppm polychlorinated biphenyl content.
mesh_terms: D000273:Adipose Tissue / Q000032:analysis; D000818:Animals; D001140:Aroclors / Q000008:administration & dosage / Q000097:blood / Q000633:toxicity*; D004781:Environmental Exposure; D005393:Fish Diseases / Q000139:chemically induced / Q000473:pathology*; D007668:Kidney / Q000473:pathology; D008099:Liver / Q000473:pathology; D009401:Nephrosis / Q000139:chemically induced / Q000473:pathology / Q000662:veterinary; D011078:Polychlorinated Biphenyls / Q000633:toxicity*; D012487:Salmonidae; D013154:Spleen / Q000473:pathology; D014337:Trout
chemical_list: D001140:Aroclors; D011078:Polychlorinated Biphenyls