Behavioural sequelae of methaqualone in man and in the monkey (Macaca mulatta).
1 Residual effects in man of methaqualone hydrochloride (400 mg) were studied by adaptive tracking and by reaction time. Performance was measured at 10 h, 13 h, 16 h, 19 h and 34 h after the overnight ingestion of the drug. There was no evidence of impaired performance on adaptive tracking from 10 h to 19 h, but enhanced performance (P = 0.001) was observed 34 h after ingestion. With reaction time an increase (P = 0.01) was observed 10 h and a decrease (P = 0.05) was observed 19 h after ingestion. 2 Effects in the monkey (Macaca mulatta) of methaqualone (20 and 30 mg/kg body weight) were studied by a delayed matching task in which total response time was measured. No consistent effects on matching behaviour or on total response time were observed 2 h after intraperitoneal injection. 3 The studies suggest that methaqualone hydrochloride may be a valuable hypnotic for occasional use by persons involved in skilled activity.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003071:Cognition / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D000882:Haplorhini; D006801:Humans; D008253:Macaca mulatta; D008702:Methaqualone / Q000494:pharmacology*; D009048:Motor Skills / Q000187:drug effects*; D010424:Pentobarbital / Q000494:pharmacology; D010919:Placebos; D011930:Reaction Time / Q000187:drug effects*; D013647:Task Performance and Analysis
D010919:Placebos; D008702:Methaqualone; D010424:Pentobarbital