Comparison of alpha-MSH and several vasoactive substances on vascular resistance in the feline mesenteric vascular bed.
The effects of alpha-MSH and several other vasoactive substances on the mesenteric vascular bed were studied in the anesthetized cat under conditions of controlled blood flow. Intra-arterial injections of alpha-MSH in doses of 10, 30, and 100 mug resulted in significant dose-related decreases in mesenteric arterial perfusion pressure but little or no effect on systemic arterial pressure. The vasodilator response to alpha-MSH was breif in duration and resistance to flow was decreased 10, 18, and 26 percent at 10, 30, and 100 mug. These significant changes after alpha-MSH were of a much smaller magnitude than were observed after prostaglandins E1 and E2, isoproterenol, bradykinin or glyceryl trinitrate and differed completely from the increased resistance after angiotensin II and norepinephrine.
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001920:Bradykinin / Q000494:pharmacology; D002415:Cats; D005260:Female; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009074:Melanocyte-Stimulating Hormones / Q000494:pharmacology*; D008643:Mesentery / Q000098:blood supply* / Q000187:drug effects; D005996:Nitroglycerin / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D011458:Prostaglandins E / Q000494:pharmacology; D014655:Vascular Resistance / Q000187:drug effects*
D011458:Prostaglandins E; D000804:Angiotensin II; D009074:Melanocyte-Stimulating Hormones; D005996:Nitroglycerin; D007545:Isoproterenol; D001920:Bradykinin; D009638:Norepinephrine