Experimental biharzial bladder cancer: tryptophan metabolism in nonhuman primates experimentally infected with Schistosoma haematobium.
A nonhuman primate species infected with Schistosoma haematobium provided a model system for controlled studies on biharzial bladder cancer. Urinary excretion of tryptophan metabolites by capuchin monkeys (Cebus apella) was similar to that of humans when expressed per g creatinine. Liver tryptophan oxygenase activity of the capuchin monkeys was comparable to that of humans. Excretion of 3-hydroxykynurenine and 3-hydroxyanthranilic acid was elevated above control levels in capuchin monkeys infected experimentally with S. haematobium. The capuchin-S. haematobium system closely resembles the human biharziasis system and offers a reproducible laboratory model system for the controlled study of the parasitology, pathogenesis, and biochemistry of biharzial bladder cancer.
D015095:3-Hydroxyanthranilic Acid / Q000652:urine; D000818:Animals; D004195:Disease Models, Animal; D000882:Haplorhini; D007737:Kynurenine / Q000652:urine; D008099:Liver / Q000201:enzymology; D009374:Neoplasms, Experimental / Q000378:metabolism; D010215:Papio; D012552:Schistosomiasis / Q000150:complications*; D014364:Tryptophan / Q000378:metabolism* / Q000652:urine; D014366:Tryptophan Oxygenase / Q000378:metabolism
D015095:3-Hydroxyanthranilic Acid; D007737:Kynurenine; D014364:Tryptophan; D014366:Tryptophan Oxygenase