title: Glucose-insulin treatment of lactic acidosis in phenformin-treated diabetics.
abstract: Four cases of lactic acidosis in phenformintreated diabetics are presented. Blood lactate before treatment was 5.7, 9.4, 10.7 and 17.8 mM/1, respectively. Treatment with glucose, insulin and bicarbonate resulted in correction of acidosis and hyperlactataemia. This therapy is recommended in phenformin-induced lactic acidosis.
mesh_terms: D000368:Aged; D001639:Bicarbonates / Q000097:blood / Q000627:therapeutic use; D001786:Blood Glucose / Q000378:metabolism; D003920:Diabetes Mellitus / Q000188:drug therapy*; D016883:Diabetic Ketoacidosis / Q000139:chemically induced / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D005947:Glucose / Q000627:therapeutic use*; D006801:Humans; D007328:Insulin / Q000627:therapeutic use*; D007773:Lactates / Q000097:blood*; D008875:Middle Aged; D010629:Phenformin / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D001639:Bicarbonates; D001786:Blood Glucose; D007328:Insulin; D007773:Lactates; D010629:Phenformin; D005947:Glucose