title: Evolution and taxonomy in the genus Brucella: progesterone induction of filterable forms of Brucella abortus type 2 with revertant characteristics essentially indistinguishable in vitro from those of Brucella ovis.
abstract: An organism essentially indistinguishable from Brucella ovis, as determined by conventional and manometric techniques of identifying Brucella organisms, was derived in vitro from a strain of Brucella abortus type 2. The basic mechanism responsible for derivation of this organism was incomplete reversion of the L-forms to their original parental characteristics. The agent used to induce the L-forms was a physiologic concentration of progesterone incorporated in the growth medium.
mesh_terms: D005075:Biological Evolution; D002002:Brucella / Q000254:growth & development / Q000378:metabolism; D002003:Brucella abortus / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D007740:L Forms; D011374:Progesterone / Q000494:pharmacology*
chemical_list: D011374:Progesterone