[Animal experiments on the maintenance dose of D-penicillamine].
The question of a D-penicillamine maintenance dose was tested by the load resulting in rupture of excised strips of dorsal skin of male albino rats. The reduction in load resulting in rupture (-48.5 per cent) obtained by 14 days of treatment with 320 mg/kg/day orally can be maintained completely over a treatment period of 28 days by daily administration of half the dose (160 mg/kg/day orally). Animal experimental findings correspond well with the procedure applied in hospital, to fix the maintenance dose at 30-50 per cent of the maximal dose after full effect is reached.
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D004334:Drug Administration Schedule; D004548:Elasticity; D008134:Long-Term Care; D008297:Male; D010396:Penicillamine / Q000008:administration & dosage* / Q000627:therapeutic use; D051381:Rats; D012867:Skin / Q000187:drug effects
D010396:Penicillamine
Tierexperimentelle Untersuchungen zur D-Penicillamin-Erhaltungsdosis