[Differential effect of azathioprine on the activation of B cells].
The in vitro antibody response to most T-independent antigens is inhibited by Azathioprine (Az) only at concentrations of 1-10 mug/ml. In contrast, B cell response to T-dependent antigens and to the T-independent antigen TNP-Polyacrylamide is sensitive to low Az concentrations (10(-2) mug/ml). These data suggest the existence of two different B cell activation processes : a. The activation by B cell mitogens or T-independent antigens with a mitogenic moiety which are Az-resistant; b. The activation by T-dependent antigens or T-independent antigens without a mitogenic moiety which are Az-sensitive.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D001379:Azathioprine / Q000494:pharmacology*; D001402:B-Lymphocytes / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes; D051379:Mice; D008819:Mice, Nude; D013601:T-Lymphocytes / Q000276:immunology
D001379:Azathioprine
Effet différentiel de l'Azathioprine sur l'activation des cellules B