Synthesis and in vitro evaluation of 8-hydroxyquinoline analogs as inhibitors of dental plaque.
A group of 5-substituted 8-hydroxyquinolines with predicted log P values in the 1-4 range has been prepared from either 8-hydroxyquinoline or its appropriate derivative. 5-Formyl-, 5-iodo-, 5-fluoro-, 5-acetyl-, and 5-methoxymethyl-8-hydroxyquinoline in addition to methyl-5(8-hydroxyquinolyl)acetate and ethyl 5-(8-hydroxyquinolyl)acetate displayed greater in vitro antiplaque activity than 8-hydroxyquinoline.
D003773:Dental Plaque / Q000517:prevention & control*; D006801:Humans; D006912:Hydroxyquinolines / Q000138:chemical synthesis*; D066298:In Vitro Techniques; D015125:Oxyquinoline / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D013295:Streptococcus mutans / Q000187:drug effects
D006912:Hydroxyquinolines; D015125:Oxyquinoline