title: Anti-inflammatory and analgetic effects of indomethacin following removal of impacted mandibular third molars.
abstract: In a double-blind, clinical study, the analgetic and anti-inflammatory effects of indomethacin (Indocid) were evaluated following removal of impacted or semi-impacted mandibular third molars in 50 patients. Regarding analgetic effectiveness, 84% of the patients reported good or excellent relief from pain after administration of 50 mg of indomethacin three times a day for 2 days. The analgetic effect of indomethacin was significantly better than that of placebo. There was no significant difference in anti-inflammatory effectiveness between indomethacin and placebo. The degree of trismus postoperatively was significantly less in the indomethacin group. Due to a rather high incidence of side effects (28%) in the central nervous system and the gastrointestinal tract, the routine use of indomethacin in oral surgery is not recommended.
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D008963:Molar; D010146:Pain / Q000188:drug therapy; D010919:Placebos; D013530:Surgical Wound Infection / Q000517:prevention & control; D014081:Tooth Extraction; D014095:Tooth, Impacted / Q000601:surgery*
chemical_list: D010919:Placebos; D007213:Indomethacin