Is there any association between elevated serum prolactin level and mammary adenocarcinoma induced by 7,12-dimethylbenz(alpha)anthracene.
The association between mammary carcinogenesis induced by 7,12-dimethylbenz(alpha)anthracene (DMBA) in the rat, the influence by manipulations of its hepatic metabolism and the secretion of prolactin has been investigated. Various test compounds: coumarin, 4-methylcoumarin, phenobarbital and CCl4 all elevated serum prolactin level, but only coumarin and 4-methylcoumarin reduced tumor incidence. These observations do not support the assumption that the suppression of DMBA-induced breast adenocarcinoma by coumarin and 4-methylcoumarin is mediated via prolactin.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000230:Adenocarcinoma / Q000139:chemically induced / Q000378:metabolism*; D000818:Animals; D001551:Benz(a)Anthracenes; D003374:Coumarins; D005260:Female; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000378:metabolism*; D006899:Mixed Function Oxygenases / Q000378:metabolism; D010634:Phenobarbital / Q000494:pharmacology; D011388:Prolactin / Q000097:blood*; D051381:Rats; D013268:Stimulation, Chemical
D001551:Benz(a)Anthracenes; D003374:Coumarins; D015127:9,10-Dimethyl-1,2-benzanthracene; D011388:Prolactin; D006899:Mixed Function Oxygenases; D010634:Phenobarbital