[The influence of infusions of methionine and methionine+glucose on the morphology and function of self-emptying jejunal blind loops in the rat (author's transl)].
The present study was undertaken to investigate whether an amino-acid solution or a mixture of amino acid and sugar could have a nutritive effect on the intestinal mucosa. Self-emptying blind loops of rat jejunum were perfused 3 times daily for 24 or 31 days, through a tube conveyed subcutaneously to the back of the neck, with a Ringer solution or a saline containing methionine and glucose or methionine alone. Methionine infusion induced a significant rise in the villus height of the mucosa of the blind loops, which was accompanied by an increased glucose absorption, as determined in vivo. In mucosal homogenates there was a tendency toward an increase in dipeptidase activity but not in disaccharidase level. Infusion of a mixture of glucose and methionine led to lengthened crypts, as well as larger villi. Glucose transport was again increased, and there was a small rise in both dipeptidase and disaccharidase activities.
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D004150:Dipeptidases / Q000378:metabolism; D004186:Disaccharidases / Q000378:metabolism; D005260:Female; D005947:Glucose / Q000378:metabolism / Q000494:pharmacology*; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000201:enzymology; D007583:Jejunum / Q000187:drug effects* / Q000201:enzymology; D008715:Methionine / Q000494:pharmacology*; D010477:Perfusion; D051381:Rats
D008715:Methionine; D004186:Disaccharidases; D004150:Dipeptidases; D005947:Glucose
Untersuchungen zum Einflubeta von Methionin- und Methionin-Glucose-Lösungen auf Morphologie und Funktion der Schleimhaut selbstentleerender jejunaler Blindschlingen der Ratte