[The histogenesis of Kaposi sarcoma: a histochemical and electronmicroscopical study (author's transl)].
1. Histologically, Morbus Kaposi is primarily characterized by a proliferation of streams composed of spindle-shaped cells, by vascular slits lined by cells, and by a minor cellular inflammatory reaction. 2. The cells lining the vascular slits resemble endothelial cells and exhibit strong alkaline phosphatase activity and a clear leucinaminopeptidase activity. They contain Weibel-Palade bodies. 3. The ultrastructural analysis of the tumor cells shows a proliferative formation resembling capillary sprouts with and without lumina. The lumina are composed primarily of poorly differentiated endothelial cells. A second typical cellular component are fibroblast-like tumor cells possibly derived from perithelial cells. 4. Indicative of M.K. are also extravasation and phagocytosis of erythrocytes with intracytoplasmic decomposition, and storage of myelinlike structures somewhat resembling Schwannian-cells. 5.


CONCLUSIONS
M.K. is characterized by a multifocal neoplasia of capillary like structures and by a progressive sarcomatous development.
D000368:Aged; D000469:Alkaline Phosphatase / Q000378:metabolism; D002196:Capillaries / Q000648:ultrastructure; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D004912:Erythrocytes; D004950:Esterases / Q000378:metabolism; D005260:Female; D005347:Fibroblasts; D006651:Histocytochemistry; D006801:Humans; D007365:Intercellular Junctions / Q000648:ultrastructure; D008113:Liver Neoplasms / Q000201:enzymology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010586:Phagocytes; D012514:Sarcoma, Kaposi / Q000201:enzymology / Q000473:pathology*; D012878:Skin Neoplasms / Q000201:enzymology / Q000473:pathology*
D004950:Esterases; D000469:Alkaline Phosphatase
Zur Histogenese des Sarcoma idiopathicum multiplex haemorrhagicum (Morbus Kaposi): Eine histochemische und elektronenmikroskopische Studie