[Comparative assessment of the specific activity of several thyrotropin-releasing-hormone analogs].
A study was made of the effect of replacement of the second and third amino acid residues of the thyrotropin-releasing hormone on the manifestation of the specific biological activity assessed by the radioimmune method of determination of the thyrotropic hormone in rats. Replacement of histidine by alanine caused a 100-fold and by phenylalanine - a 10-fold reduction of the activity. Glycine analogue proved to be inactive. The biological activity of TRH analogue (Glu-Phe-Pro CH3) was only 10 times less in comparison with the activity of the standard. The second double modified analogue of this hormone (Glu-Gly-Ser NH2) was incapable of influencing the release of the thyrotropic hormone by the hypophysis.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D010902:Pituitary Gland / Q000187:drug effects*; D010903:Pituitary Gland, Anterior / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D013972:Thyrotropin / Q000378:metabolism*; D013973:Thyrotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology
D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin
Sravnitel'naia otsenka spetsificheskoĭ aktivnosti nekotorykh analogov tireotropin-relizing-gormona