On the mechanism of polychlorinated biphenyl-induced hypobilirubinaemia.
Treatment of normal rats with a polychlorinated biphenyl mixture of DDT increased liver microsomal protein concentration. Hepatic microsomal bilirubin UDP-glucuronyltransferase activity was elevated in the DDT-treated, but not in the polychlorinated biphenyl-treated rats. In contrast polychlorinated biphenyl, but not DDT, reduced serum bilirubin concentrations in jaundiced Gunn rats, as did sulphadiazine; sulphonamides compete with bilirubin for binding sites on plasma albumin. Polychlorinated biphenyls appear to lower serum bilirubin concentration by reducing the binding of bilirubin to plasma protein.
D000818:Animals; D001663:Bilirubin / Q000097:blood*; D001798:Blood Proteins / Q000378:metabolism; D003634:DDT / Q000494:pharmacology; D005260:Female; D014453:Glucuronosyltransferase / Q000378:metabolism; D008099:Liver / Q000187:drug effects; D008862:Microsomes, Liver / Q000201:enzymology; D009929:Organ Size / Q000187:drug effects; D011078:Polychlorinated Biphenyls / Q000009:adverse effects*; D011485:Protein Binding; D051381:Rats; D013411:Sulfadiazine / Q000494:pharmacology
D001798:Blood Proteins; D013411:Sulfadiazine; D003634:DDT; D011078:Polychlorinated Biphenyls; D014453:Glucuronosyltransferase; D001663:Bilirubin