Mast cell sensitizing antibodies in myasthenia gravis.
Mast Cells Sensitizing Antibodies (MCSAb) were detected in patients with Myasthenia Gravis (MGr), by the Indirect Mast Cell Degranulation (IMCD). In most of the examined sera a correlation could be established between MCSAb and fluorescent antibodies to muscle and to thymus. The MCSAb were specific for muscle extract. They were resistant to prolonged heating and their reactivity in the IMCD test was not complement depending. Presence of MCSAb in sera of patients with MGr evidences the auto-allergic features of this disease.
D000818:Animals; D000917:Antibody Formation; D001323:Autoantibodies / Q000032:analysis*; D002986:Clinical Trials as Topic; D005455:Fluorescent Antibody Technique; D000882:Haplorhini; D006801:Humans; D007106:Immune Sera / Q000302:isolation & purification; D008407:Mast Cells / Q000276:immunology*; D009132:Muscles / Q000276:immunology; D009157:Myasthenia Gravis / Q000276:immunology*; D011817:Rabbits; D013950:Thymus Gland / Q000276:immunology
D001323:Autoantibodies; D007106:Immune Sera