title: [Morphological findings after Busulfan long term therapy (author's transl)].
abstract: Autopsy findings from two patients who have been treated for several years with Busulfan because of chronic myelogenous leukemia are reported. Beside a pulmonary fibrosis epithelial dysplasias in the respiratory tract, the liver and kidney were detected. Furthermore, in one case beside a proliferation of reticulate cells in the spleen a distinct plasmocytosis of the bone marrow and a so-called "wasting syndrome" were found. The pathogenesis of these changes is still unkown; it may be that immunological processes play a role.
mesh_terms: D000311:Adrenal Glands / Q000473:pathology; D000368:Aged; D001344:Autopsy; D001853:Bone Marrow / Q000473:pathology; D002066:Busulfan / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007668:Kidney / Q000473:pathology; D007951:Leukemia, Myeloid / Q000188:drug therapy / Q000473:pathology*; D008099:Liver / Q000473:pathology; D008134:Long-Term Care; D008168:Lung / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000473:pathology; D013154:Spleen / Q000473:pathology; D013997:Time Factors
chemical_list: D002066:Busulfan
vernacular_title: Morphologische Befunde nach Busulfan-Langzeittherapie