Retinal capillaries: proliferation of mural cells in vitro.
Capillaries from bovine, monkey, and human retinas maintained in tissue culture produced a monolayer of cells. Autoradiographic and electron microscopic evidence indicated that the mural cells (intramural pericytes) were the cells that proliferated. Since intramural pericytes are damaged selectively in diabetes mellitus, their availability in culture will be useful in seeking means to control diabetic retinopathy.
D000818:Animals; D002196:Capillaries / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism; D002417:Cattle; D002478:Cells, Cultured; D003930:Diabetic Retinopathy / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D000882:Haplorhini; D006801:Humans; D008253:Macaca mulatta; D012171:Retinal Vessels / Q000166:cytology / Q000254:growth & development*; D013936:Thymidine / Q000378:metabolism
D006003:Glycogen; D013936:Thymidine