Karyotype evolution in cell lines of Drosophila melanogaster.
The chromosomal changes occurred in two independent cell lines (GM2 and GM3) of Drosophila melanogaster maintained in medium supplemented with serum and in serum-free medium were compared. In both culture conditions and in both lines a chromosomal evolution was revealed. Structural and numerical variations were analysed. The breaks giving rise to rearrangements were at heterochromatic level. Moreover, a tetraploidisation followed by loss of chromosomes or of portions of chromosomes recalls an analogous cycle observed in human cells.
D000818:Animals; D002460:Cell Line; D002869:Chromosome Aberrations; D002875:Chromosomes; D003470:Culture Media; D004331:Drosophila melanogaster; D014644:Genetic Variation; D006570:Heterochromatin; D011123:Polyploidy
D003470:Culture Media; D006570:Heterochromatin