Heterogeneity in in vitro response to progesterone and melphalan of mammary tumours induced in the rat by 7,12-DMBA.
Five mammary tumours induced in rats by 7, 12-DMBA were each divided into four sections, and studied as cell suspensions in vitro for response to melphalan or progesterone measured as H3-thymidine incorporation. Heterogeneity towards melphalan and progesterone was found within all five tumours, but the mode of reaction of the two drugs differed. The biological relevance of these findings is discussed.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D001551:Benz(a)Anthracenes; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology*; D008558:Melphalan / Q000494:pharmacology*; D011374:Progesterone / Q000494:pharmacology*; D051381:Rats
D001551:Benz(a)Anthracenes; D011374:Progesterone; D015127:9,10-Dimethyl-1,2-benzanthracene; D008558:Melphalan