Intraprostatic Injections of various antitumour compounds into rats: Part II. Chronic effects.
Histopathological studies were carried out at intervals of one, two and three months after a single injection of one of seven antitumour compounds into the prostates of adult male CR rats. The histological findings indicate mainly a long term effect of the compounds tested on the glandular epithelium of the rat prostate. The effect is strictly local and no side effects were seen.
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D003609:Dactinomycin / Q000008:administration & dosage / Q000494:pharmacology; D005472:Fluorouracil / Q000008:administration & dosage / Q000494:pharmacology; D007267:Injections; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000494:pharmacology; D008937:Mitomycins / Q000008:administration & dosage / Q000494:pharmacology; D011467:Prostate; D051381:Rats; D013852:Thiotepa / Q000008:administration & dosage; D013997:Time Factors
D000970:Antineoplastic Agents; D008937:Mitomycins; D003609:Dactinomycin; D013852:Thiotepa; D005472:Fluorouracil; D008727:Methotrexate