Distribution and metabolism of 3H-2,5,2',5'-tetrachlorobiphenyl in rats.
Distribution and metabolism of an isomeric polychlorinated biphenyl were determined in rats. Over 70% of a single dose of 3H-2,5,2',5'-tetrachlorobiphenyl was excreted in the feces and another 13% in the urine during a 14-day period. Adipose tissue, blood, skin, and liver were found to contain low levels of the compound. Over 90% of the excreted tritiated compound was found to be metabolized, the major metabolite being identified as 3-OH-2,5,2',5'-tetrachlorobiphenyl. All of the unmetabolized 2,5,2',5'-tetrachlorobiphenyl was eliminated by the alimentary route.
D000273:Adipose Tissue / Q000032:analysis; D000818:Animals; D001774:Blood Chemical Analysis; D002845:Chromatography; D005243:Feces / Q000032:analysis; D005612:Freeze Drying; D007420:Intestine, Large / Q000032:analysis; D007668:Kidney / Q000032:analysis; D008099:Liver / Q000032:analysis / Q000648:ultrastructure; D008297:Male; D013058:Mass Spectrometry; D011078:Polychlorinated Biphenyls / Q000032:analysis / Q000378:metabolism* / Q000652:urine; D051381:Rats; D012867:Skin / Q000032:analysis; D013055:Spectrophotometry, Infrared; D013270:Stomach / Q000032:analysis; D013347:Subcellular Fractions / Q000032:analysis; D013737:Testis / Q000032:analysis; D014316:Tritium
D014316:Tritium; D011078:Polychlorinated Biphenyls