Lipid peroxidation in human erythrocytes in tocopherol deficiency.
Lipid peroxidation following exposure to H2O2 vapour was abnormally great in the erythrocytes from certain patients with low plasma tocopherol concentrations. Following treatment of such patients with tocopherol, erythrocyte lipid peroxidation was markedly reduced. The in vitro addition of tocopherol reduced lipid peroxidation in erythrocytes from both normal subjects and tocopherol-deficient patients.
D000368:Aged; D001386:Azides / Q000494:pharmacology; D003864:Depression, Chemical; D004912:Erythrocytes / Q000187:drug effects*; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D008055:Lipids / Q000097:blood*; D008297:Male; D008314:Malonates / Q000096:biosynthesis; D008875:Middle Aged; D010084:Oxidation-Reduction; D012964:Sodium / Q000494:pharmacology; D013268:Stimulation, Chemical; D014804:Vitamin B Deficiency / Q000097:blood*; D014810:Vitamin E / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use; D014811:Vitamin E Deficiency / Q000188:drug therapy
D001386:Azides; D008055:Lipids; D008314:Malonates; D014810:Vitamin E; D012964:Sodium; D006861:Hydrogen Peroxide