Colcemid sensitivity of fission yeast: permeability and detoxification properties of resistant mutants.
Mutants of Schizosaccharomyces pombe, which were resistant to concentrations of colcemid inhibitory to the wild-type parent, were not diminished in their permeability to colcemid or colchicine. They also did not modify colcemid to a detectable derivative or to a product that was incapable of binding to brain tubulin. The resistance of these mutants was therefore via mechanisms different from those of permeability and detoxification known for animal cells.
D001692:Biological Transport; D002845:Chromatography; D003078:Colchicine / Q000378:metabolism / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D012440:Saccharomyces / Q000187:drug effects* / Q000378:metabolism; D014404:Tubulin / Q000378:metabolism
D014404:Tubulin; D003078:Colchicine