[Therapy of meningitis (author's transl)].
For the specific and unspecific treatment of purulent meningitis, penicillin, ampicillin and chloramphenicol are usually sufficient. Only resistant pathogens (Klebsiella, Pseudomonas among others) and meningitis in infants require other treatment. Cephalosporins and aminoglycosides only come into consideration for the treatment of very rare exceptional cases. The still relatively poor prognosis of purulent meningitis is largely independent of the efficacy of the treatment. Delay in beginning therapy, lack of intensive care, primary diseases and complications are principally responsible for this. Medicamentous prophylaxis is only possible for meningococcal meningitis. The distribution of antibiotics in the CSF is irregular. Also the antibacterial activity in the CSF is different from culture media.
D000328:Adult; D000667:Ampicillin / Q000134:cerebrospinal fluid / Q000627:therapeutic use; D002228:Carbenicillin / Q000134:cerebrospinal fluid / Q000627:therapeutic use; D002555:Cerebrospinal Fluid / Q000382:microbiology; D002648:Child; D002701:Chloramphenicol / Q000134:cerebrospinal fluid / Q000627:therapeutic use; D006801:Humans; D007231:Infant, Newborn; D007362:Intensive Care Units; D008581:Meningitis / Q000209:etiology / Q000517:prevention & control / Q000628:therapy*; D008583:Meningitis, Haemophilus; D008585:Meningitis, Meningococcal; D008826:Microbial Sensitivity Tests; D010400:Penicillin G / Q000627:therapeutic use; D011379:Prognosis; D012189:Retrospective Studies; D013997:Time Factors
D002701:Chloramphenicol; D000667:Ampicillin; D002228:Carbenicillin; D010400:Penicillin G
Therapie der Meningitis