title: Fc- and complement-receptor rosette-forming cell ratios in human tonsils and peripheral blood.
abstract: Lymphocytes were investigated for both Fc- and complement-rosette-forming cell activities. At least three subpopulations differing in the relative activities of the Fc and complement receptors have been disclosed. In human tonsils a subpopulation of B lymphocytes had a higher complement-receptor activity than Fc-receptor activity. In contrast, the peripheral cells from a patient with a lymphoma and another with an undiagnosed lymphocytic disease contained a population of B lymphocytes with higher Fc-receptor than complement- receptor activity. In three patients with chronic lymphocytic leukemia, B lymphocytes contained both Fc- and complement-receptor activities. No differences between complement- and Fc-receptor activities were evident in normal human peripheral blood. Fc-receptor, but not complement-receptor activity was inhibited by 2% gamma-globulin, or 8 X 10(3) M  iodoacetate. EDTA at 1.7 X 19(-2) M concentration has no effect upon Fc- or complement-rosette-forming cells. The activity of both receptors was diminished at 4 degrees C.
mesh_terms: D001402:B-Lymphocytes / Q000276:immunology*; D003165:Complement System Proteins / Q000502:physiology*; D004492:Edetic Acid / Q000494:pharmacology; D006801:Humans; D007104:Immune Adherence Reaction; D007141:Immunoglobulin Fc Fragments / Q000032:analysis*; D007461:Iodoacetates / Q000494:pharmacology; D007945:Leukemia, Lymphoid / Q000276:immunology; D008223:Lymphoma / Q000276:immunology; D014066:Palatine Tonsil / Q000276:immunology*; D011947:Receptors, Antigen, B-Cell; D011955:Receptors, Drug / Q000187:drug effects; D013696:Temperature
chemical_list: D007141:Immunoglobulin Fc Fragments; D007461:Iodoacetates; D011947:Receptors, Antigen, B-Cell; D011955:Receptors, Drug; D003165:Complement System Proteins; D004492:Edetic Acid