title: Cerebral protection by barbiturate anesthesia. Use after middle cerebral artery occlusion in Java monkeys.
abstract: Regional cerebral ischemia was produced in 18 Java monkeys by permanent middle cerebral artery (MCA) occlusion. All monkeys were thereafter paralyzed (pancuronium bromide, 0.05 mg/kg/hr) and sedated (diazepam, 0.1 mg/kg/hr) for a 48-hour period. Thirty minutes after MCA occlusion, pentobarbital sodium anesthesia was induced in nine of the monkeys (14 mg/kg) and maintained for 48 hours (7 mg/kg every two hours), with continuous supportive care. After 48 hours, all drugs were discontinued; the monkeys were observed for five days, and then killed. Seven of the control monkeys developed a cerebral infarction, three did not survive past the 48 hours of intensive care, and the other four had a notable neurologic deficit. All pentobarbital monkeys survived the seven days, but four had a cerebral infarction and two of these had a notable neurologic deficit. These differences were statistically significant.
mesh_terms: D000769:Anesthesia, Inhalation; D000818:Animals; D001929:Brain Edema / Q000188:drug therapy; D001930:Brain Injuries / Q000188:drug therapy; D002539:Cerebral Arterial Diseases / Q000188:drug therapy; D002561:Cerebrovascular Disorders / Q000188:drug therapy* / Q000401:mortality; D004569:Electroencephalography; D005260:Female; D000882:Haplorhini; D007238:Infarction / Q000517:prevention & control; D008297:Male; D010424:Pentobarbital / Q000627:therapeutic use*
chemical_list: D010424:Pentobarbital