The melanocytotoxic action of 4-hydroxyanisole.
Cultured normal mammalian melanocytes exposed to a variety of antioxidants in the presence of millimolar concentrations of 4-hydroxyanisole exhibit dose-dependent modifications of cytotoxicity. While some antioxidants reduced the extent of damage produced by 4-hydroxyanisole, others appeared to increase it. Similar effects were found in a model system using lysis of human erythrocytes as an index of cell damage. Estimations on rat liver microsomes in the presence of tyrosinase and 4-hydroxyanisole showed increased peroxidation only at low substrate concentrations.
D000447:Aldehydes / Q000096:biosynthesis; D000818:Animals; D000840:Anisoles / Q000633:toxicity*; D000975:Antioxidants / Q000494:pharmacology; D001205:Ascorbic Acid / Q000494:pharmacology; D004156:Catechol Oxidase / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000187:drug effects; D005978:Glutathione / Q000494:pharmacology; D006168:Guinea Pigs; D006801:Humans; D008314:Malonates / Q000096:biosynthesis; D008544:Melanocytes / Q000187:drug effects*; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D010084:Oxidation-Reduction; D051381:Rats; D014810:Vitamin E / Q000494:pharmacology
D000447:Aldehydes; D000840:Anisoles; D000975:Antioxidants; D008314:Malonates; D014810:Vitamin E; D004156:Catechol Oxidase; D005978:Glutathione; D001205:Ascorbic Acid