[Lanthanum and scorpion venom on the isolated guinea pig ileum].
In the guinea-pig isolated ileum, lanthanum increases the quantity of spontaneously released acetylcholine and induces contracture of this muscle. We have shown that the latter phenomenon is not a consequence of the former. We conclude that it could be due to the Ca++ displaced by La+++. The scorpion venom effects are abolished by lanthanum. We explain this observation by blockage of Ca++ fluxes.
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D000997:Antivenins; D001692:Biological Transport; D002118:Calcium / Q000378:metabolism*; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D007811:Lanthanum / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects*; D009132:Muscles / Q000378:metabolism; D012605:Scorpions; D014688:Venoms / Q000494:pharmacology*
D000997:Antivenins; D014688:Venoms; D007811:Lanthanum; D000109:Acetylcholine; D002118:Calcium
Lanthane et venin de Scorpion sur l'iléon isolé de Cobaye