In vitro transformation of hamster chondrocytes by 4-nitroquinoline 1-oxide.
Hamster sternal chondrocytes were transfored morphologically in vitro 29-51 days after exposure to 4-nitroquinoline 1-oxide for 3 h. The transformed chondrocytes were randomly oriented, piled up and grew continuously. These cells produced nodules when transferred to the cheek pouch of a hamster. Histologically, these nodules revealed chondromatous patterns. Untreated cells in the control cultures failed to produce nodules.
D015112:4-Nitroquinoline-1-oxide / Q000494:pharmacology*; D000818:Animals; D002356:Cartilage / Q000187:drug effects*; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D006224:Cricetinae; D008297:Male; D008647:Mesocricetus; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology; D009600:Nitroquinolines / Q000494:pharmacology*; D014184:Transplantation, Homologous
D009600:Nitroquinolines; D015112:4-Nitroquinoline-1-oxide