Lead poisoning in dogs at the University of Pennsylvania Veterinary Hospital.
Twenty-seven dogs with lead poisoning were admitted to the University of Pennsylvania Veterinary Hospital from July, 1963, to April, 1975. The major source of the lead was paint. A common history was ingestion of plaster or paint scrapings during room renovation. Most of the dogs were less than 1 year old and had clinical signs referable to the gastrointestinal or the nervous system, or both. The gastrointestinal signs, in order of frequency, were vomiting, anorexia, tender abdomen, diarrhea, and constipation. The neurologic signs, in order of frequency, were hysteria, convulsions, ataxia, blindness, and mydriasis. The finding of many nucleated erythrocytes without severe anemia was nearly pathognomonic for lead poisoning. Of 14 affected dogs subjected to abdominal radiography, 9 had evidence of ingested radiopaque material. A mean blood lead concentration of 18.8 mug/100 ml, with a range of 0 to 50 mug/100 ml, was found for 26 dogs that were hospitalized for problems unrelated to lead poisoning. Of the 27 dogs with lead poisoning, 22 had their blood analyzed for lead. This group had blood lead values ranging from 40 to 530 mug/100 ml. Seven of the affected dogs were monitored throughout their period of treatment with calcium ethylenediaminetetraacetate. The concentration of lead in the blood decreased quickly after the initiation of treatment but leveled off after 2 or 3 days. The initial rapid phase probably corresponded to the removal of weakly bound or extracellular lead, whereas the slow phase probably corresponded to strongly bound or intracellular lead.
D000367:Age Factors; D000818:Animals; D002118:Calcium / Q000627:therapeutic use; D004285:Dogs; D004492:Edetic Acid / Q000627:therapeutic use; D007854:Lead / Q000097:blood; D007855:Lead Poisoning / Q000097:blood / Q000188:drug therapy / Q000662:veterinary*; D010150:Paint / Q000506:poisoning; D010414:Pennsylvania; D012640:Seizures / Q000662:veterinary; D014839:Vomiting / Q000662:veterinary
D007854:Lead; D004492:Edetic Acid; D002118:Calcium