title: A report on the use of Arvin in patients with pre-gangrene of the lower limb.
abstract: Sixteen patients with arteriosclerosis and pre-gangrene of a lower limb were treated for 5 days by intravenous injection of Arvin. The effects of the injection on plasma fibrinogen, the viscosity of blood and the patient's symptoms were measured. There was a 90 per cent reduction in plasma fibrinogen and a significant reduction in the viscosity of blood. Five patients experienced some relief of pain during the treatment. In only one patient were the symptoms relieved permanently.
mesh_terms: D000328:Adult; D000368:Aged; D000721:Ancrod / Q000627:therapeutic use*; D001161:Arteriosclerosis / Q000188:drug therapy*; D001809:Blood Viscosity / Q000187:drug effects; D010450:Endopeptidases / Q000627:therapeutic use*; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D005734:Gangrene / Q000188:drug therapy*; D006801:Humans; D007866:Leg; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D005340:Fibrinogen; D010450:Endopeptidases; D000721:Ancrod