Antibacterial activity of nitropyrroles, nitrothiphenes, and aminothiophenes in vitro.
The antibacterial activities of nitropyrroles, nitrothiophenes, and aminothiophenes were studied. Replacement of the nitro group with an amino group enhanced the activity of the thiophene compounds.
D000588:Amines / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D004754:Enterobacter / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D009574:Nitro Compounds / Q000494:pharmacology*; D011514:Proteus vulgaris / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D011758:Pyrroles / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship; D013876:Thiophenes / Q000494:pharmacology*
D000588:Amines; D009574:Nitro Compounds; D011758:Pyrroles; D013876:Thiophenes