Studies with carcinogen-induced mammary carcinoma of the rat. The trial of auto-immunization to inhibit tumor formation after the surgical removal of tumors.
Auto-immunization treatment of carcinogen-fed rats using homogenates of carcinogen-induced tumors did not have any adverse effect on new tumor formation and growth as well as local recurrences. Auto-immunization treatments did not change the degree or nature of the inflammatory reaction observed in carcinogen-induced tumors. Auto-antibodies against carcinogen-infiltration of various intensity in the stroma of the tumor suggested that host definsi mechanism may involve in the course of development this authochtonous tumor.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D000951:Antigens, Neoplasm / Q000008:administration & dosage / Q000302:isolation & purification; D002291:Carcinoma, Papillary / Q000139:chemically induced / Q000276:immunology* / Q000601:surgery; D005260:Female; D006386:Hemagglutination Tests; D007114:Immunization; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000276:immunology* / Q000601:surgery; D008748:Methylcholanthrene; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D011817:Rabbits / Q000276:immunology; D051381:Rats; D012756:Sheep / Q000276:immunology
D000951:Antigens, Neoplasm; D008748:Methylcholanthrene; D015127:9,10-Dimethyl-1,2-benzanthracene