Enzymatic modification of aminoglycoside antibiotics: a new 3-N-acetylating enzyme from a Pseudomonas aeruginosa isolate.
A new 3-N-aminoglycoside acetyltransferase is described, which possesses a wider substrate range than any such enzyme so far discovered in clinical isolates of antibiotic-resistant bacteria.
D000123:Acetyltransferases / Q000032:analysis*; D000617:Aminoglycosides / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D001673:Biodegradation, Environmental; D004926:Escherichia coli / Q000378:metabolism; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000201:enzymology*; D012853:Sisomicin / Q000378:metabolism
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000123:Acetyltransferases; D012853:Sisomicin