Fulminant liver failure: clinical and experimental study.
Clinical experience of some newer methods of hepatic support is described. The results are unpredictable and far from satisfactory. The need for an animal model in which potential therapeutic methods can be studied is emphasized. Such a model based on carefully imposed ischaemic insult to the liver in the absence of portacaval shunting is described. It is suggested that bacterial presence in the bowel together with a depression of the liver reticuloendothelial function plays an important part in the early and rapid mortality of acute liver failure. Temporary auxiliary liver transplantation using an allograft or a closely related primate heterograft seem to be the 2 best available methods of hepatic support for potentially reversible acute liver failure.
D000328:Adult; D000818:Animals; D003427:Cross Circulation; D004195:Disease Models, Animal; D004285:Dogs; D005078:Exchange Transfusion, Whole Blood; D005260:Female; D000882:Haplorhini; D006501:Hepatic Encephalopathy / Q000628:therapy; D006506:Hepatitis A / Q000628:therapy; D006801:Humans; D007511:Ischemia / Q000628:therapy; D008099:Liver / Q000098:blood supply; D008107:Liver Diseases / Q000401:mortality / Q000628:therapy*; D016031:Liver Transplantation; D008253:Macaca mulatta; D008297:Male; D008875:Middle Aged; D010215:Papio; D010477:Perfusion; D051381:Rats; D013552:Swine; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous