title: The effects of cosmic particle radiation on pocket mice aboard Apollo XVII: appendix III. evaluation of viscera and other tissues.
abstract: Histopathological findings in the lungs, livers, bone marrows, small intestines, gonads, kidneys, and other tissues of the four pocket mice (Perognathus longimembris) that survived the Apollo XVII flight were evaluated in the light of their immediate environment and as targest of HZE cosmic ray particles. Results of this study failed to disclose changes that could be ascribed to the HZE particle radiation. Decreased numbers of erythropoietic cells in the bone marrow of the flight mice were probably related to the increased oxygen pressure. The small intestine showed no changes. Ovaries and tests appeared normal. Two of the three surviving male flight mice displayed early stages of spermatogenesis, just as ground-based controls did at the same season. Abnormalities were also not found in the thyroid, parathyroids, adrenals, or kidneys. The status of the juxtaglomerular apparatus could not be evaluated. The lungs exhibited nonspecific slight rections. A variety of incidental lesions were noted in the livers of both the flight mice and their controls. The heart muscle showed nothing that could be regarded as pathological. Sections of skeletal muscle examined were free from significant change.
mesh_terms: D000302:Adrenal Cortex / Q000528:radiation effects; D000818:Animals; D001853:Bone Marrow / Q000528:radiation effects; D003359:Cosmic Radiation; D005260:Female; D006066:Gonads / Q000528:radiation effects; D006321:Heart / Q000528:radiation effects; D007421:Intestine, Small / Q000528:radiation effects; D007668:Kidney / Q000528:radiation effects; D008099:Liver / Q000528:radiation effects; D008168:Lung / Q000528:radiation effects; D008297:Male; D051379:Mice; D009132:Muscles / Q000528:radiation effects; D010100:Oxygen; D010280:Parathyroid Glands / Q000528:radiation effects; D010313:Partial Pressure; D011830:Radiation Effects; D012523:Sarcocystosis / Q000453:epidemiology; D013026:Space Flight; D013091:Spermatogenesis; D013961:Thyroid Gland / Q000528:radiation effects; D014481:United States
chemical_list: D010100:Oxygen