Nebcin in the treatment of experimental Pseudomonas keratitis.
When the ocular toxicity and the in vivo and in vitro effects of gentamicin, Nebcin, and saline solution were compared in experimentally induced Pseudomonas keratitis in rabbits, both antibiotics showed the same toxicity for the rabbits' conjunctival tissues. But Nebcin showed better in vitro and in vivo results than gentamicin, and the clinical effect was confirmed by culture study: significant numbers of organisms were recovered from the corneas of the gentamicin-treated rabbits but none from the corneas of the Nebcin-treated rabbits.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D005839:Gentamicins / Q000627:therapeutic use / Q000633:toxicity; D007634:Keratitis / Q000188:drug therapy*; D011552:Pseudomonas Infections / Q000188:drug therapy*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D011817:Rabbits; D014031:Tobramycin / Q000494:pharmacology / Q000627:therapeutic use* / Q000633:toxicity
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D014031:Tobramycin