[Preliminary results of the use of a new rodent filaria, Dipetalonema dessetae (Bain, 1973), in the evaluation of filaricides].
The sensitivity of this filarial worm living in his natural host has been identified with respect to 2 well known filaricidal compounds. With diethylcarbamazine the microfilaremia drops rapidly but not completely and a long term treatment destroys the adults. Suramin is toxic to the adults and to the microfilariae. This experimental model is therefore more sensitive than anything presently available.
D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D004049:Diethylcarbamazine / Q000494:pharmacology; D004153:Dipetalonema / Q000187:drug effects*; D004353:Drug Evaluation, Preclinical; D005369:Filaricides / Q000494:pharmacology*; D008842:Microfilariae / Q000187:drug effects; D012377:Rodentia / Q000469:parasitology; D013498:Suramin / Q000494:pharmacology
D000871:Anthelmintics; D005369:Filaricides; D013498:Suramin; D004049:Diethylcarbamazine
Résultats préliminaires sur l'utilisation d'une nouvelle filaire de rongeur Dipetalonema dessetae (Bain, 1973) dans l'évaluation des antifilariens