Alterations in plasma copper, zinc, amino acids, and seromucoid during Rocky Moutain spotted fever in guinea pigs.
Guinea pigs inoculated with virulent Rickettsia rickettsii responded with a significant increase in plasma copper concentration within 1 day, preceding fever and detectable rickettsemia by 2 and 4 days, respectively. A decrease in serum zinc concentration coinciding with peak rickettsemia was detectable on Day 5. Evidence of altered host nitrogen metabolism during this illness included a doubling of plasma seromucoid concentration and a significant rise in the plasma phenylalanine/tyrosine ratio.
D000596:Amino Acids / Q000097:blood*; D000818:Animals; D003300:Copper / Q000097:blood*; D005334:Fever; D006168:Guinea Pigs; D009088:Mucoproteins / Q000097:blood*; D010649:Phenylalanine / Q000097:blood; D012284:Rickettsia rickettsii; D012373:Rocky Mountain Spotted Fever / Q000097:blood*; D013997:Time Factors; D014443:Tyrosine / Q000097:blood; D015032:Zinc / Q000097:blood*
D000596:Amino Acids; D009088:Mucoproteins; D014443:Tyrosine; D010649:Phenylalanine; D003300:Copper; D015032:Zinc