[Investigation of the choleretic action of febuprol on healthy test subjects (author's transl)].
The choleretic effect of 3-butoxy-1-phenoxypropanol-(2), Febuprol (INN), was examined in healthy volunteer subjects. In a dose range from 50 to 200 mg, the total bile is dose-dependent and excretion is significantly increased. The excretion of the bile constituents bile acids, bilirubin, cholesterol and phospholipids is increased proportionally with the bile secretion. The lithogenic index remains unaltered.
D000328:Adult; D001646:Bile / Q000378:metabolism*; D001663:Bilirubin / Q000378:metabolism; D002756:Cholagogues and Choleretics / Q000494:pharmacology*; D002784:Cholesterol / Q000378:metabolism; D002793:Cholic Acids / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004386:Duodenum; D005260:Female; D006801:Humans; D007419:Intestinal Secretions / Q000032:analysis / Q000187:drug effects* / Q000378:metabolism; D008099:Liver / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D010146:Pain; D010743:Phospholipids / Q000378:metabolism; D020005:Propanols
D002756:Cholagogues and Choleretics; D002793:Cholic Acids; D010743:Phospholipids; D020005:Propanols; D002784:Cholesterol; D001663:Bilirubin
Untersuchung der choleretischen Wirkung von Febuprol an gesunden Versuchspersonen