Elevated 7S immunoglobulin and acute phase proteins in adjuvant-injected chickens.
Injection of chickens with FCA or FIA supplemented with either Bordetella pertussis or Nocardia rubra induced greatly increased serum levels of 7S Ig and proteins with alpha-, beta-, and gamma-mobility in electrophoresis. The serum protein changes were correlated with the development of DHS and the formation of a large allergic granuloma. The 7S Ig was considered "nonspecific" since it was not adsorbed with the bacterial cells. The alpha-, beta-, and gamma-mobility proteins were identified as acute phase proteins as they also were induced by injection of chickens with turpentine-oil; however, increased serum levels of 7S Ig were not similarly increased.
D000818:Animals; D001797:Blood Protein Electrophoresis; D001798:Blood Proteins / Q000378:metabolism*; D002645:Chickens; D005260:Female; D005620:Freund's Adjuvant / Q000008:administration & dosage; D006099:Granuloma / Q000097:blood / Q000276:immunology*; D006968:Hypersensitivity, Delayed; D005779:Immunodiffusion; D007074:Immunoglobulin G / Q000032:analysis*; D007136:Immunoglobulins / Q000032:analysis*; D007273:Injections, Intramuscular; D013848:Thigh / Q000473:pathology
D001798:Blood Proteins; D007074:Immunoglobulin G; D007136:Immunoglobulins; D005620:Freund's Adjuvant