title: [Action of decamethoxin on diphtherial exotoxin].
abstract: The results of the study of the detoxicating effect of decamethoxin on diphtheria toxin are presented. It was noted that decamethoxin in subbacteriostatic concentrations inhibited the process of the toxin production in Corynebacteria diphtheriae. The detoxicating effect of the drug was clearly evident when used in a concentration of 10gamma/ml at a 2-hour exposure. Decamethoxin in a dose of 0.1 gamma/ml neutralized the effect of the diphtheria toxin on contact for 24 hours.
mesh_terms: D000818:Animals; D003353:Corynebacterium diphtheriae / Q000187:drug effects / Q000378:metabolism / Q000472:pathogenicity; D003470:Culture Media; D003650:Decamethonium Compounds / Q000494:pharmacology*; D003864:Depression, Chemical; D004167:Diphtheria Toxin / Q000096:biosynthesis / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006168:Guinea Pigs; D008826:Microbial Sensitivity Tests; D011817:Rabbits
chemical_list: D003470:Culture Media; D003650:Decamethonium Compounds; D004167:Diphtheria Toxin
vernacular_title: Deĭstvie dekametoksina na difteriĭnyĭ ékzotoksin.