title: The immediate effect of TSH on renal iodide excretion rate in rabbits.
abstract: The renal iodide excretion rate was determined in unrestrained female rabbits by means of conventional clearance technique or continuous monitoring of the whole body disappearance of iv injected 125I-iodide using an implanted Geiger-Muller detector. The immediate effect of pharmacological doses of bovine TSH was studied by both methods and a significant decrease in iodide excretion rate was recorded following the administration of a single TSH dose of 4 IU. The effect of TSH lasted 3-6 h. Injection of 10-20 mug TRH caused a transient delay in iodide disappearance (30-50 min) while 2-20 mug triiodothyronine iv or sc had no immediate effect on the iodide disappearance.
mesh_terms: D000818:Animals; D002940:Circadian Rhythm; D005260:Female; D007454:Iodides / Q000097:blood / Q000378:metabolism* / Q000652:urine; D013972:Thyrotropin / Q000494:pharmacology*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology; D013997:Time Factors; D014284:Triiodothyronine / Q000494:pharmacology
chemical_list: D007454:Iodides; D014284:Triiodothyronine; D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin