[Effects of LSD-25 on the cell cycle of Pleurodeles Waltlii Michah. embryos treated at the end of gastrulation].
LSD-25 lengthens the G2 and M phases of the cell cycle in embryos treated at the late gastrula stage and labelled with tritiated thymidine. This antimitotic effect of LSD-25 is comparable to the similar effect of colchicine or vinblastine, but is weaker. Cell distribution among the phases of the cell cycle has been studied by cytophotometry; mitotic index has been calculated, and curves of labelled mitoses variation have been established.
D000663:Amphibians / Q000196:embryology; D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D004625:Embryo, Nonmammalian / Q000187:drug effects; D008238:Lysergic Acid Diethylamide / Q000494:pharmacology*; D008938:Mitosis / Q000187:drug effects; D013997:Time Factors
D008238:Lysergic Acid Diethylamide
Effets du LSD-25 sur le cycle cellulaire d'embryons de Pleurodeles waltlii Michah, traités en fin de gastrulation