title: Allograft cytotoxicity. Role of T lymphocytes bearing a receptor for complement.
abstract: The ability of sensitized spleen populations to kill allogenic mouse cells in vitro is lost after depletion of cells bearing receptors for C3. It is suggested that complement receptor T lymphocytes (T-CRL) play a role in the effector phase of specific cell-mediated cytotoxicity. The finding of large C3 rosette-forming cells staining for a specific T marker further supports the view that activated T cells may bear C3 receptors.
mesh_terms: D000818:Animals; D001666:Binding Sites, Antibody; D002460:Cell Line; D003176:Complement C3; D003165:Complement System Proteins; D003601:Cytotoxicity Tests, Immunologic; D007104:Immune Adherence Reaction; D007111:Immunity, Cellular; D008212:Lymphocyte Depletion; D012515:Mast-Cell Sarcoma / Q000276:immunology; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000276:immunology; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D014184:Transplantation, Homologous
chemical_list: D003176:Complement C3; D003165:Complement System Proteins