title: [High titer cold agglutinins with anti-pr specificity after rubella infection (author's transl)].
abstract: High titer cold agglutinins (CA) after rubella infection are reported. When the rubella exanthema disappeared the clinical aspect of a cold agglutinin disease was observed. Three weeks after the appearance of the cutaneous eruption the CA titer reached a maximum of 1/8000, to then continuously fall off to normal values within 20 weeks. Double diffusion tests showed that the isolated CA were IgM proteins that possess only chi-type light chains. In spite of normal protein- and immunoelectrophoresis patterns obtained with whole serum samples, the isolated CA showed restricted electrophoretic mobility and a deformation of the precipitate typical for monoclonal immunoglobulins. In contrast to the common anti-I specificity of IgM CA, the IgM CA described showed anti-Pr specificity. Possible interrelations between CA specificities and types of germs inducing reactive cold agglutination are discussed.
mesh_terms: D000328:Adult; D000373:Agglutinins / Q000145:classification / Q000302:isolation & purification*; D000918:Antibody Specificity; D000941:Antigens; D001323:Autoantibodies / Q000302:isolation & purification; D002648:Child; D003080:Cold Temperature / Q000009:adverse effects*; D004912:Erythrocytes / Q000276:immunology; D005076:Exanthema / Q000503:physiopathology; D006801:Humans; D007122:Immunoelectrophoresis; D007075:Immunoglobulin M / Q000145:classification / Q000302:isolation & purification*; D007146:Immunoglobulin lambda-Chains / Q000032:analysis; D012409:Rubella / Q000276:immunology*; D013696:Temperature
chemical_list: D000373:Agglutinins; D000941:Antigens; D001323:Autoantibodies; D007075:Immunoglobulin M; D007146:Immunoglobulin lambda-Chains
vernacular_title: Hochtitrige Kälteagglutinine der Spezilfität Anti-Pr nach Rötelninfektion