Initiation-promotion skin carcinogenesis and immunological competence.
The immune competence of mice during initiation-promotion skin carcinogenesis was determined by skin allograft rejection and lymphocyte mitogenesis. The carcinogen 7, 12-dimethylbenzanthracene inhibited the cellular immune competence of mice while lymphocytes from croton oil treated mice had enhanced PWM response. Chlorphenesin, a stimulator of cellular immunity, was found to inhibit tumorigenesis in initiation-promotion skin carcinogenesis when injected during promotion.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000276:immunology / Q000494:pharmacology; D000818:Animals; D002743:Chlorphenesin / Q000494:pharmacology; D003436:Croton Oil / Q000276:immunology / Q000494:pharmacology; D005260:Female; D006084:Graft Rejection; D007111:Immunity, Cellular / Q000187:drug effects; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D008805:Mice, Inbred A; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000276:immunology*; D012878:Skin Neoplasms / Q000139:chemically induced / Q000276:immunology*
D015127:9,10-Dimethyl-1,2-benzanthracene; D003436:Croton Oil; D002743:Chlorphenesin