[Effect of pentobarbital on the morphology and respiration of glial cells in primary culture].
Dissociated glial cells from cell-born Rat brains in primary culture were exposed to 5 X 10(-4) M pentobarbital-Na and 2.5 X 10(-5) M morphine. Only pentobarbital was found to induce a morphological change resembling a maturation into protoplasmic astrocytes. This modification was accompanied by an increase of oxygen consumption (50-75%). No evidence could be obtained for the presence of dependence on the barbiturate or morphine, but a certain degree of tolerance to pentobarbital was observed.
D000818:Animals; D000831:Animals, Newborn; D001253:Astrocytes / Q000166:cytology; D001921:Brain / Q000166:cytology; D002478:Cells, Cultured; D003864:Depression, Chemical; D004361:Drug Tolerance; D009020:Morphine / Q000494:pharmacology; D009457:Neuroglia / Q000166:cytology / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects; D010424:Pentobarbital / Q000494:pharmacology*; D051381:Rats
D009020:Morphine; D010424:Pentobarbital
Effet du pentobarbital sur la morphologie et la respiration des cellules gliales en culture primaire