[Permeability of dialysis membranes for hepatitis-B virus: on the prophylaxis of hepatitis in a haemodialysis centre (author's transl)].
Dialysis fluids of two hepatitis-Bs (HBs) antigen-positive dialysis patients were tested for hepatitis-B virus. Total dialysate volume of 5.5 litres each - as obtained on haemodialysis with the Redy-recirculation system - was concentrated by ultrafiltration and trap and rate-zonal ultracentrifugation, followed by fractionation, and purified. Electron-microscopic evidence of permeability of an intact dialysis membrane for hepatitis-B was obtained. Concentration of hepatitis-B virus was at least 10(3) to 10(4) particles per total volume. Because of the potential infectiousness of the dialysis apparatus by effective heat sterilisation after every dialysis is essential.
D000293:Adolescent; D000368:Aged; D005260:Female; D006509:Hepatitis B / Q000517:prevention & control / Q000635:transmission; D006515:Hepatitis B virus; D006358:Hot Temperature; D006801:Humans; D007688:Kidneys, Artificial / Q000295:instrumentation*; D008567:Membranes, Artificial; D008854:Microscopy, Electron; D010539:Permeability; D006435:Renal Dialysis; D013242:Sterilization
D008567:Membranes, Artificial
Permeabilität von Dialysemembranen in Hämodialysegeräten für das Hepatitis-B-Virus. Ein Beitrag zur Expositionsprophylaxe der Hepatitis in Hämodialysezentren