Effect of atropine upon the cardiovascular system during soman-induced respiratory depression.
The effects of atropine, doxapram and isoproterenol upon soman-induced respiratory depression were investigated in the monkey. Administration of atropine resulted in an immediate increase in heart rate accompanied by a gradual increase in respiratory rate. The improvement in the EEG pattern coincided with improvement in respiratory function. Administration of either doxapram or isoproterenal during soman-induced apnea failed to significantly alter any of the physiological parameters. Clonazepam was used to control soman-induced seizure activity and convulsions.
D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002998:Clonazepam / Q000494:pharmacology; D003864:Depression, Chemical; D004315:Doxapram / Q000494:pharmacology; D004569:Electroencephalography; D005260:Female; D000882:Haplorhini; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D007427:Intracranial Pressure / Q000187:drug effects; D007545:Isoproterenol / Q000494:pharmacology; D008253:Macaca mulatta; D008297:Male; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D012119:Respiration / Q000187:drug effects*; D012999:Soman / Q000494:pharmacology*
D009943:Organophosphorus Compounds; D002998:Clonazepam; D001285:Atropine; D004315:Doxapram; D012999:Soman; D007545:Isoproterenol