[Synthesis of the 24 R and 24 S diastereoisomers of 24,25-dihydroxycholecalciferol (24,25(OH)2D3)].
The resolution of 5-cholestene-3 beta, 24 RS,25 triol 3,24-diacetate into the diastereoisomers 24 R and 24 S by means of liquid chromatography is described. Bromination, dehydrobromination and ultraviolet irradiation of both diastereoisomers led to 24 R,25 (OH)2D3 and 24 S,25 (OH)2D3 respectively. Their structure was further confirmed by thin layer chromatography, ultraviolet and mass spectroscopy.
D002853:Chromatography, Liquid; D004100:Dihydroxycholecalciferols / Q000138:chemical synthesis*; D006887:Hydroxycholecalciferols / Q000138:chemical synthesis*; D013237:Stereoisomerism
D004100:Dihydroxycholecalciferols; D006887:Hydroxycholecalciferols
Synthèse des diastéréoisomères 24 R et 24 S du dihydroxy-24,25 cholécalciférol [24,25(OH)2D3]