Pulmonary infiltrates with eosinophilia and urinary symptoms during disodium cromoglycate treatment. A case report.
A 64-year-old asthmatic woman began to suffer from urinary irritation after 5 months' treatment with disodium cromoglycate. After 10 months she contracted, additionally, a dry, hacking cough and gradually increasing exercise-induced dyspnoea. Chest X-ray revealed scattered, micronodular infiltrations in both lungs, and her spirogram was clearly restrictive. Peripheral blood showed eosinophilia of 23.5%. Urine was clean. When DSCG was withdrawn, her urinary symptoms and cough disappeared overnight, and her dyspnoea improved within weeks, as did her chest X-ray. Inhalation provocation test with DSCG 2 months later resulted in an immediate asthmatic reaction followed by a possible delayed-type reaction 9 hours later. Disodium cromoglycate is regarded as the possible aetiologic agent.
D004205:Cromolyn Sodium / Q000009:adverse effects* / Q000627:therapeutic use; D004342:Drug Hypersensitivity; D004804:Eosinophils; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000139:chemically induced*; D008875:Middle Aged; D001745:Urinary Bladder Diseases / Q000139:chemically induced*
D004205:Cromolyn Sodium