Permeability of normal and cancerous rat bladder to antineoplastic agents.
Normal rat bladder is moderately permeable to intravesically instilled thiotepa, but impermeable to instilled cytosine arabinoside, 5-fluorouracil, or adriamycin. Permeability to thiotepa increased as neoplastic changes of the bladder epithelium were induced with a carcinogenic diet.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D004848:Epithelium; D005200:FANFT; D005260:Female; D007958:Leukocyte Count; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism; D010539:Permeability; D051381:Rats; D013852:Thiotepa / Q000378:metabolism / Q000627:therapeutic use; D013997:Time Factors; D001743:Urinary Bladder / Q000378:metabolism* / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism
D000970:Antineoplastic Agents; D005200:FANFT; D013852:Thiotepa