A comparative trial of hyposensitization in 1973 in the treatment of hay fever using Pollinex and Alavac-P.
A direct comparison was made in 112 hay fever patients of hyposensitization treatment with glutaraldehyde-pollen-tyrosine adsorbate (Pollinex) and with alum-precipitated pyridine extract (Alavac-P) which is an accepted form of treatment, its efficacy having been shown by a comparative trial against a placebo preparation. No significant difference could be detected between the results of the two forms of treatment. Seventy-seven per cent of patients responded with improvement following treatment with the tyrosine adsorbed vaccine, and 81% of those receiving the alum-precipitated vaccine. Side effects from treatment, both local and general, were generally of an infrequent or mild nature for both vaccines.
D000293:Adolescent; D000328:Adult; D000447:Aldehydes / Q000627:therapeutic use*; D000534:Alum Compounds; D052179:Antigens, Plant; D002648:Child; D002986:Clinical Trials as Topic; D003888:Desensitization, Immunologic; D005260:Female; D005976:Glutaral / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010936:Plant Extracts; D011058:Pollen; D011725:Pyridines / Q000627:therapeutic use; D006255:Rhinitis, Allergic, Seasonal / Q000188:drug therapy*; D014443:Tyrosine / Q000627:therapeutic use*
D000447:Aldehydes; D000534:Alum Compounds; D052179:Antigens, Plant; D010936:Plant Extracts; D011725:Pyridines; D014443:Tyrosine; C014155:Parietaria judaica pollen; D005976:Glutaral