title: The pathophysiological changes of experimental fat embolism: early pre-hypoxaemic changes.
abstract: Glyceryl trioleate has been injected into greyhounds as a model of the fat embolism syndrome. Pulmonary vascular pressures, systemic arterial pressure and cardiac output were determined at regular intervals over an 8-hour period. It has been shown that glyceryl tioleate causes an increased pulmonary vascular resistance and a fall in cardiac output. These effects are mediated partly by a direct mechanical block of pulmonary vessels and partly through a thrombogenic property of the injected fat. The relevance of these findings to the clinical situation is discussed and a sequence of events for the fat embolism syndrome is proposed.
mesh_terms: D000818:Animals; D001794:Blood Pressure; D002302:Cardiac Output; D004285:Dogs; D004620:Embolism, Fat / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology*; D000860:Hypoxia / Q000209:etiology / Q000503:physiopathology; D008168:Lung / Q000473:pathology; D009206:Myocardium / Q000473:pathology; D011651:Pulmonary Artery; D013997:Time Factors; D014304:Triolein; D014655:Vascular Resistance
chemical_list: D014304:Triolein