[Clinical investigations of the effect of tolbutamide and glibenclamide on pancreatic glucagon secretion (author's transl)].
The effects of tolbutamide, glibenclamide, arginine and arginine in combination with glibenclamide upon insulin, glucagon and glucose serum levels have been studied in healthy young men. Sulphonylurea-induced hypoglycemia is followed by a reactive hyperglucagonemia. Arginine-induced hyperglucagonemia is not suppressed by sulphonylureas. While there exists no difference between tolbutamide and glibenclamide-stimulated glucagon secretion, there is one with regard to insulin secretion.
D000328:Adult; D001120:Arginine / Q000494:pharmacology; D001786:Blood Glucose / Q000032:analysis; D005934:Glucagon / Q000097:blood / Q000378:metabolism*; D005905:Glyburide / Q000494:pharmacology*; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D014044:Tolbutamide / Q000494:pharmacology*
D001786:Blood Glucose; D007328:Insulin; D005934:Glucagon; D001120:Arginine; D014044:Tolbutamide; D005905:Glyburide
Klinisch experimentelle Untersuchungen zur Beeinflussung der pankreatischen Glukagoninkretion durch Tolbutamid und Glibenclamid