Pharmacological inhibition of digestive secretions in the management of pancreaticoduodenal fistulas.
We report the pharmacological inhibition of secretions of the gastrointestinal tract for the prevention and management of pancreatic and duodenal fistulas. Nasogastric aspiration to remove gastric secretions and decrease motility and an anticholinergic drug, a carbonic anhydrase inhibitor and intravenous hyperalimentation to inhibit secretions were used to prevent pancreatic fistulas. Patients with established duodenal and/or pancreatic fistulas received local treatment consisting of lavage of the fistulous tract and skin protection in addition to the parenteral therapy. Three cases of successful prevention of pancreatic fistulas and three cases of managemtnt of duodenal fistulas are presented.
D000086:Acetazolamide / Q000494:pharmacology / Q000627:therapeutic use*; D005753:Gastric Mucosa / Q000187:drug effects*; D006801:Humans; D007412:Intestinal Fistula / Q000188:drug therapy* / Q000628:therapy; D010185:Pancreatic Fistula / Q000188:drug therapy* / Q000517:prevention & control; D010289:Parenteral Nutrition, Total; D011182:Postoperative Care; D011413:Propantheline / Q000494:pharmacology
D011413:Propantheline; D000086:Acetazolamide