Evolution of aurosomes in rabbit synovial membrane.
Intra-articular injection of sodium aurothiomalate (Myochrysine) into rabbit knee joints produced lysomes (aurosomes) of a characteristic morphology in synovial intimal cells and subsynovial macrophages. Such lysosomes are distinct and different from other lysosomes and those seen after injection of sodium thiomalate. A study of the morphological events that occur after injection of gold salt shows that at first the aurosome contains electrondense granules but later membranous formations (myelinoid membranes) presenting as rod-like and curled structures develop. With electron probe x-ray analysis, gold, phosphorus, and traces of calcium were detected in the aurosome.
D000818:Animals; D004577:Electron Probe Microanalysis; D005260:Female; D006046:Gold / Q000008:administration & dosage / Q000032:analysis; D007270:Injections, Intra-Articular; D008247:Lysosomes / Q000032:analysis / Q000648:ultrastructure*; D008297:Male; D010743:Phospholipids / Q000032:analysis; D010758:Phosphorus / Q000032:analysis; D011817:Rabbits; D013583:Synovial Membrane / Q000032:analysis / Q000187:drug effects* / Q000648:ultrastructure
D010743:Phospholipids; D010758:Phosphorus; D006046:Gold