Alterations of glycolipid glycosyltrasnferase levels in lymphoma and lymphoid tissues of lymphoma-bearing hamsters.
Thymus from lymphoma-bearing hamsters in advanced stages of tumor growth showed enhanced activities of four glycolipid-glycosyltransferases which lead to the step-wise synthesis of lactosylceramide to Forssman hapten. The alpha-galactosyltransferase activity of the thymus was decreased until day 6 of inoculation but increased thereafter. The activities of all the transferases tested were significantly lowered in lymphoma tissue. The level of UDP-galactose pyrophosphatase did not correlate with the transferase activities.
D000818:Animals; D006224:Cricetinae; D005646:Fucosyl Galactose alpha-N-Acetylgalactosaminyltransferase / Q000378:metabolism; D005700:Galactosyltransferases / Q000378:metabolism*; D006358:Hot Temperature; D050356:Lipid Metabolism; D008223:Lymphoma / Q000201:enzymology*; D010743:Phospholipids / Q000378:metabolism; D011755:Pyrophosphatases / Q000378:metabolism; D013950:Thymus Gland / Q000201:enzymology*
D010743:Phospholipids; D005700:Galactosyltransferases; D005646:Fucosyl Galactose alpha-N-Acetylgalactosaminyltransferase; D011755:Pyrophosphatases