Microbiological studies on some bladder irrigation fluids.
A 1.5% glycine solution has recently been introduced as a bladder irrigation fluid. In this study, glycine solution was compared with two other recognised bladder irrigants (chlorhexidine and noxythiolin) for its inhibitory activity against common urinary tract pathogens. Glycine solution supported the growth of nearly 50% of the bacterial strains tested whereas chlorhexidine and noxythiolin were completely inhibitory. In quantitative studies with selected strains it was found that growth could be initiated from as few as 200 organisms/ml. It was concluded that glycine solution was capable of supporting bacterial growth and thus, from a microbiological viewpoint, was unsuitable as a bladder irrigant.
D001419:Bacteria / Q000187:drug effects* / Q000254:growth & development; D002710:Chlorhexidine / Q000494:pharmacology; D013293:Enterococcus faecalis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D005998:Glycine / Q000494:pharmacology*; D007709:Klebsiella / Q000187:drug effects; D009677:Noxythiolin / Q000494:pharmacology; D011513:Proteus mirabilis / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012996:Solutions; D007507:Therapeutic Irrigation; D001743:Urinary Bladder / Q000382:microbiology*; D014546:Urinary Catheterization
D012996:Solutions; D009677:Noxythiolin; D002710:Chlorhexidine; D005998:Glycine