[The clinical value of 51 chrome-EDTA clearance].
In routine diagnostics the glomerular filtration rate was in most cases determined by endogenic creatinine clearance. Possibilities of errors in this method are unreliable accumulation of urine, influencibility of the creatinine values by the muscular mass and various exogenic factors. The chromium-51-EDTA-clearance is to be regarded as a more exact method. After single intravenous injection of about 150 muCi Cr-51-EDTA (single-shot-method) the impulse rates in the serum are measured after 60, 100, 140 and 180 min in the bore-hole-crystal. Up to now the number of patients examined is about 300, additionally 6 persons who underwent binephrectomy. Elaboration of a computer programme for the calculation of the clearance values. The best approach is achieved by non-linear regression. There exists a reciprocal connection between serum creatinine and Cr-51-EDTA-clearance. Values lower than 90 ml/min must be regarded as pathological. The Cr-51-EDTA-clearance is particularly valuable in the so-called creatinine-blind region, in which it gives a more reliable information about the beginning reduction of the glomerular filtration rate, as calculation of the correlation and repeated examinations show. The method can be recommended for the clinical routine diagnostics.
D002860:Chromium Radioisotopes; D003404:Creatinine / Q000097:blood; D004492:Edetic Acid / Q000378:metabolism*; D005919:Glomerular Filtration Rate / Q000379:methods*; D006801:Humans; D009392:Nephrectomy; D006435:Renal Dialysis
D002860:Chromium Radioisotopes; D004492:Edetic Acid; D003404:Creatinine
Die klinische Bedeutung der 51Chrom-EDTA-Clearance