[Experimental study on changes in serum amino acid levels following choledochus ligature and subsequent biliary reconstruction (author's transl)].
Changes in serum amino acid levels and time course of hepatic function derangements were studied in mongrel dogs with choledochus ligature and subsequent biliarly reconstruction through cholecysto-duodenostomy. In the second week after choledochus ligature, serum ammonium level increased along with intensification of jaundice. After four weeks, GPT activity was higher than GOT and plasma albumin level markedly decreased with similar reduction in serum amino acid levels. Biliary reconstruction, when performed during three or four weeks after the ligature, restored the hepatic function as well as serum amino acid levels toward normal. When it was performed in the fifth or sixth week after the ligation, the liver function did not restore and serum levels of total amino acids, essential and non-essential amino acids increased even 4 weeks lapse after reconstruction. Among the changes observed, His., Val., Ser., Arg., Leu., Ileu, Phe, and Lys. were increased, whereas Pro. and Cys. disappeared from the serum. These results suggest that recovery from metabolic changes of amino acids due to choledochus ligature depends upon the duration of obstructive jaundice, i.e., it appears necessary to perform the biliary reconstruction within four weeks after the initiation of obstruction.
D000596:Amino Acids / Q000097:blood*; D000601:Amino Acids, Essential / Q000097:blood; D000641:Ammonia / Q000097:blood; D000818:Animals; D001662:Biliary Tract Surgical Procedures; D001798:Blood Proteins / Q000032:analysis; D002779:Cholestasis / Q000097:blood; D003135:Common Bile Duct / Q000601:surgery*; D004285:Dogs; D008026:Ligation; D013997:Time Factors; D014508:Urea / Q000097:blood
D000596:Amino Acids; D000601:Amino Acids, Essential; D001798:Blood Proteins; D000641:Ammonia; D014508:Urea