title: Post-extraction hemostasis during coumarin anticoagulant therapy with a locally applied coagulation-active substance.
abstract: A safe and simple method for the dento-alveolar attendance of patients on coumarin derivative therapy is reported. It eliminates the need to interrupt anticoagulant administration, while a physiologic coagulation-active substance consisting of fibrin, thrombin, and the patient's venous blood is used for hemostasis. This easy-to-prepare substance was applied following 53 extractions, two alveolar corrections and one resection of the third molar, and excellent hemostasis was observed without the occurrence of a secondary hemorrhage.
mesh_terms: D000287:Administration, Topical; D003374:Coumarins / Q000627:therapeutic use*; D005337:Fibrin / Q000008:administration & dosage / Q000627:therapeutic use*; D006488:Hemostasis, Surgical / Q000379:methods; D006801:Humans; D006472:Oral Hemorrhage / Q000517:prevention & control*; D013917:Thrombin / Q000008:administration & dosage / Q000627:therapeutic use*; D014081:Tooth Extraction
chemical_list: D003374:Coumarins; D005337:Fibrin; D013917:Thrombin