title: Calcitonin treatment of post-menopausal osteoporosis. Evaluation of efficacy by principal components analysis.
abstract: The efficacy of long term treatment of senile osteoporosis by low doses of calcitonin was established using five parameters of calcium kinetics and a quantitative pain scale. Under treatment the calcium balance improved, due predominantly to a decrease in bone resorption associated with an increase in bone accretion and intestinal absorption of calcium. In addition, the hormone had a marked analgesic effect, which increased with the length of the treatment. Principal components analysis enables to establish the value of a therapeutic agent for the management of a progressive disease with period of regression like osteoporosis, for which the eficacy of previously advocated treatments had never been proven.
mesh_terms: D000375:Aging; D001862:Bone Resorption; D002113:Calcification, Physiologic; D002116:Calcitonin / Q000008:administration & dosage / Q000627:therapeutic use*; D002118:Calcium / Q000097:blood / Q000378:metabolism / Q000652:urine; D002986:Clinical Trials as Topic; D005260:Female; D005598:Fractures, Spontaneous / Q000628:therapy; D006801:Humans; D007408:Intestinal Absorption; D008134:Long-Term Care; D008297:Male; D008593:Menopause; D010024:Osteoporosis / Q000188:drug therapy*; D059408:Pain Management
chemical_list: D002116:Calcitonin; D002118:Calcium