Decreased myocardial fibrinolytic activity following temporary ischaemia and reperfusion.
The effect of temporary myocardial ischaemia (x 52 mins) and reperfusion (x 23 hrs 8 mins) on myocardial tissue fibrinolysis and 125I fibrinogen incorporation into fibrin was investigated in nine baboons. Fibrinolytic activity was reduced by 54% in the endocardium of the ischaemic reperfused myocardium and the 125I fibrinogen activity was elevated by 480%. The reduction in myocardial fibrinolytic activity following ischaemia and reperfusion may be due to endothelial damage.
D000818:Animals; D003326:Coronary Circulation; D004699:Endocardium / Q000378:metabolism; D005337:Fibrin / Q000096:biosynthesis; D005340:Fibrinogen / Q000378:metabolism; D005342:Fibrinolysis; D000882:Haplorhini; D007511:Ischemia / Q000097:blood*; D009203:Myocardial Infarction / Q000097:blood* / Q000209:etiology; D010215:Papio
D005337:Fibrin; D005340:Fibrinogen