Investigation of the inhibitory activity of some mycobacterial strains on growth of the intratracheally transplanted Deals' sarcoma in guinea pigs.
In this paper the authors describe and analyse results that they obtained by infection of the guinea pig organism carried out by subcutaneous or intratracheal application with five mycobacterial strains, namely Myco bovis BCG-Praha, Myco the H37Ra, Myco Kansasii, Myco fortuitum and Myco smegmatis. At predetermined time intervals following subcutaneously or intratracheally performed infection (on 7th, 16th, 28th and 56th day after infection) transplantation of a Deals' guinea pig sarcoma cell suspension was carried out in guinea pigs by the intraltracheal route. As it appears from the results gained the applied mycobacteria exhibit a partial inhibition of growth od Deals' guinea pig sarcoma cells of different character. From among the utilized strains the Myco bovis BCP-Praha and the Myco tbc H37Ra exhibited the highest, Myco fortuitum and Myco smegmatis the lowest inhibitory activity. Intratracheally performed infections yielded in general better results on the growth inhibition than infections carried out with the same strain but by the subcutaneous route. Furthermore, in the experiments reported on in the present paper the authors could verify their earlier experience, namely that inhibition of growth of sarcoma cells is most pronounced at the time of maximal biological activity (logarithmic phase of multiplication) of the applied mycobacterium.
D000818:Animals; D000917:Antibody Formation; D001500:BCG Vaccine; D001666:Binding Sites, Antibody; D001835:Body Weight; D002462:Cell Membrane / Q000276:immunology; D005260:Female; D006168:Guinea Pigs; D008175:Lung Neoplasms / Q000276:immunology*; D008297:Male; D009161:Mycobacterium / Q000276:immunology*; D009163:Mycobacterium bovis / Q000276:immunology; D009169:Mycobacterium tuberculosis / Q000276:immunology; D009368:Neoplasm Transplantation; D009929:Organ Size; D012509:Sarcoma / Q000276:immunology*; D012513:Sarcoma, Experimental / Q000276:immunology; D013154:Spleen / Q000033:anatomy & histology
D001500:BCG Vaccine