[Bioavailability of different brands of phenoxymethylpenicillin (author's transl)].
The bioavailability of 11 brands of phenoxymethylpenicillin was investigated in a cross-over-study in healthy volunteers. There were found some differences in the velocity of absorption, in the peaks and in the blood levels after 4 hours. The absorption rate was evaluated by comparison of area under the curve and urine-recovery after oral administration of different brands. It is suggested to control each brand of oral antibiotic preparations on bioavailability.
D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D001702:Biopharmaceutics; D004304:Dosage Forms; D004341:Drug Evaluation; D006801:Humans; D007408:Intestinal Absorption; D007700:Kinetics; D010404:Penicillin V / Q000008:administration & dosage / Q000378:metabolism*; D012996:Solutions; D013607:Tablets
D004304:Dosage Forms; D012996:Solutions; D013607:Tablets; D010404:Penicillin V
Die biologische Verfügbarkeit verschiedener Handelspräparate von Penicillin V