Glycogen synthetase activity in rat muscle in thermal trauma.
The glycogen synthetase activity and glycogen concentration were studied in rat skeletal muscle 24 hours after infliction of a burn. The active I-form of the enzyme was reduced. The total synthetase activity was unchanged. Expressed as a percentage of total synthetase activity, the I-form was decreased from 43.4% in control rats to 27.6% in burned rats. The fasting concentrations of serum insulin and muscle glycogen were not altered by the burn. The reduced synthetase I-form may explain the reduced glycogen storage capacity, demonstrated previously after a similar burn.
D000818:Animals; D002056:Burns / Q000201:enzymology*; D006003:Glycogen / Q000378:metabolism; D006006:Glycogen Synthase / Q000378:metabolism*; D007328:Insulin / Q000097:blood; D008297:Male; D009132:Muscles / Q000201:enzymology*; D010388:Pelvis; D051381:Rats
D007328:Insulin; D006003:Glycogen; D006006:Glycogen Synthase