title: [Enzymhistochemical investigations on the Harderian gland of rat and guinea pig under the influence of TSH and thyrohormones (author's transl)].
abstract: After application of TSH, trijodthyronine and thyroxine enzyme histochemical investigations were carried out on the Harderian glands of albino rats and guinea pigs. Marked changes were seen after a treatment of 9 days with TSH. Thereby in B-cells of rat appeared big vacuoles, which were clearly to be seen after oxidoreductase-reactions, but hardly to be seen after hydrolase-reactions. In guinea pigs the cells of the gland are strongly vacuolised both in controls and in treated animals. But this last group shows a great hypertrophy of the gland with widening of tubuli and acini. In both species of animals the steroid-3-beta-ol-dehydrogenase-reaction is negative. Nomenclature, specific reactions of the animals treated with hormones, function of the Harderian gland and its relevance in investigations of experimental exophthalmos are discussed.
mesh_terms: D000818:Animals; D006111:Graves Disease / Q000201:enzymology; D006168:Guinea Pigs; D006243:Harderian Gland / Q000201:enzymology*; D006651:Histocytochemistry; D006913:Hydroxysteroid Dehydrogenases; D007765:Lacrimal Apparatus / Q000201:enzymology*; D051381:Rats; D013963:Thyroid Hormones / Q000494:pharmacology*; D013972:Thyrotropin / Q000494:pharmacology*
chemical_list: D013963:Thyroid Hormones; D013972:Thyrotropin; D006913:Hydroxysteroid Dehydrogenases
vernacular_title: Enzymhistochemische Untersuchungen an der Harderschen Drüse von Ratte und Meerschweinchen unter dem Einfluss von TSH und Schild-drüsenhormonen