[Gamma heavy chain disease. A new case].
Description of a case presenting as an inflammatory polyarthritis. A uterine sarcoma was detected one year later and led to the death of the patient. The abnormal protein belonged to the gammal subclass. Biosynthesis experiments, performed on the marrow plasma cells, showed that light chains were not produced and that the molecular weight of the monomeric unit of the serum protein was slightly smaller than that of the protein secreted in vitro, suggesting the occurrence of a secondary and limited extracellular proteolysis.
D001168:Arthritis / Q000209:etiology; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D006362:Heavy Chain Disease / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007143:Immunoglobulin Heavy Chains / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008558:Melphalan / Q000627:therapeutic use; D008875:Middle Aged; D008970:Molecular Weight; D011241:Prednisone / Q000627:therapeutic use; D012509:Sarcoma / Q000150:complications; D014594:Uterine Neoplasms / Q000150:complications
D007070:Immunoglobulin A; D007143:Immunoglobulin Heavy Chains; D007075:Immunoglobulin M; D003520:Cyclophosphamide; D008558:Melphalan; D011241:Prednisone
Maladie des chaînes lourdes gamma. A propos d'une nouvelle observation