title: [Antibacterial activity of a carbenicillin-cephaloridin combination].
abstract: The effectiveness of the combination of carbenicilline and cephaloridine in the ratio of 4:1 was studied. The antibacterial activity of the association whether in vitro or in vivo is sinergic, that is, superior to the simply addition by the individual components. The hematic levels of the combination remain high up to 5 hours after the administration and are greater than those obtained with carbenicilline alone. Levels in the urine are high, therefore the species judged to be resistent in vitro may become sensitive.
mesh_terms: D000818:Animals; D001419:Bacteria / Q000187:drug effects*; D002228:Carbenicillin / Q000494:pharmacology*; D002509:Cephaloridine / Q000494:pharmacology*; D004338:Drug Combinations; D004357:Drug Synergism; D004926:Escherichia coli / Q000187:drug effects; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D011511:Proteus / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012475:Salmonella / Q000187:drug effects; D012760:Shigella / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D004338:Drug Combinations; D002228:Carbenicillin; D002509:Cephaloridine
vernacular_title: Attivitá antibatterica dell'associazione carbenicillina-cefaloridina