Alpha-chain disease with localized plasmacytoma of the intestine. Immunoperoxidase study.
An ileocaecal tumour in a patient with alpha-chain disease in remission was studied immunohistochemically by a quantitive immunoperoxidase method. The tumour which was histologically shown to be a plasmacytoma consisted of 68% alpha cells and 15% lambda cells; no kappa cells were found. Away from the tumour the pattern of immunoglobulin-producing cells was normal. It is concluded that the abnormal cell causing alpha-chain disease remains inactive and that the patient developed a plasmacytoma from a different cell clone.
D000328:Adult; D006362:Heavy Chain Disease / Q000150:complications*; D006801:Humans; D007124:Immunoenzyme Techniques; D007143:Immunoglobulin Heavy Chains; D007137:Immunoglobulin alpha-Chains; D007414:Intestinal Neoplasms / Q000150:complications* / Q000473:pathology; D008297:Male; D010954:Plasmacytoma / Q000150:complications* / Q000473:pathology
D007143:Immunoglobulin Heavy Chains; D007137:Immunoglobulin alpha-Chains