Spontaneous thrombosis of an intracranial aneurysm during treatment with epsilon aminocaproic acid.
The authors report spontaneous thrombosis of a middle cerebral artery aneurysm in a patient receiving the anti-fibrinolytic agent, epsilon aminocaproic acid. Intense vasospasm and profound neurologic deficit accompanied the initial hemorrhage. Follow-up angiography two, four and ten weeks following the initial hemorrhage demonstrated occlusion of the aneurysm and progressive thrombosis of a middle cerebral artery branch despite the disappearance of vasospasm. The patient had a persistent hemiparesis.
D000328:Adult; D000614:Aminocaproates / Q000009:adverse effects*; D015119:Aminocaproic Acid / Q000009:adverse effects*; D002543:Cerebral Hemorrhage / Q000188:drug therapy; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000150:complications* / Q000188:drug therapy; D002542:Intracranial Embolism and Thrombosis / Q000139:chemically induced* / Q000503:physiopathology
D000614:Aminocaproates; D015119:Aminocaproic Acid