[Effect of gentamicin and pentoxyl on the immunological reactivity of the body in the treatment of sepsis caused by Ps. aeruginosa].
The state of immunological reactivity was studied on 250 albino mice treated with gentamycin and pentoxyl used alone or in combination because of sepsis caused by Ps. aeruginosa. Morphological changes in the spleen and lymph nodes, as well as the dynamics of the agglutinins accumulation in the blood serum were investigated. Gentamycin had no significant effect on the plasmocytal reaction in the lymph nodes and at the same time lowered the number of the immunocompetent cells in the spleen and the titer of agglutinins in the blood serum. The use of gentamycin in combination with pentoxyl had a stimulating effect on transformation of the plasmic cells in the lymphoid organs and resulted in increased titers of agglutinins in the blood serum of the animals treated.
D000373:Agglutinins / Q000032:analysis; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000921:Antibody-Producing Cells / Q000187:drug effects; D000937:Antigen-Antibody Reactions / Q000187:drug effects*; D004359:Drug Therapy, Combination; D005839:Gentamicins / Q000494:pharmacology*; D008221:Lymphoid Tissue / Q000187:drug effects; D051379:Mice; D012157:Mononuclear Phagocyte System / Q000187:drug effects; D010950:Plasma Cells / Q000187:drug effects; D011552:Pseudomonas Infections / Q000188:drug therapy* / Q000276:immunology; D011550:Pseudomonas aeruginosa; D018805:Sepsis / Q000188:drug therapy* / Q000276:immunology; D013997:Time Factors; D014498:Uracil / Q000031:analogs & derivatives* / Q000494:pharmacology
D000373:Agglutinins; D005839:Gentamicins; D014498:Uracil
Vliianie gentamitsina i pentoksila na immunologicheskuiu reaktivnost' organizma pri lechenii sepsisa, vyzvannogo Ps. aeruginosa