Effects of meningococcal and Escherichia coli capsular polysaccharides on human and dog platelet aggregation in vitro.
Highly purified capsular polysaccharides from groups A, B, and C meningococci and from two strains of Escherichia coli did not aggregate human or dog platelets in vitro. Nor was there any detectable effect on platelet aggregation induced by adenosine diphosphate (ADP), epinephrine, or collagen. The results do not support the hypothesis that capsular polysaccharides are involved in the pathogenesis of thrombocytopenia often seen in severe infections with these bacteria.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D000942:Antigens, Bacterial; D002473:Cell Wall; D003094:Collagen / Q000494:pharmacology; D004211:Disseminated Intravascular Coagulation / Q000209:etiology; D004285:Dogs; D004731:Endotoxins / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D004926:Escherichia coli; D006801:Humans; D066298:In Vitro Techniques; D009345:Neisseria meningitidis; D010974:Platelet Aggregation / Q000187:drug effects*; D011135:Polysaccharides, Bacterial / Q000494:pharmacology*; D013921:Thrombocytopenia / Q000209:etiology
D000942:Antigens, Bacterial; D004731:Endotoxins; D011135:Polysaccharides, Bacterial; D000244:Adenosine Diphosphate; D003094:Collagen; D004837:Epinephrine