[Erythrocyte hypocromia in heterozygous hemoglobin E (beta 26 Glu replaced by Lys)].
A family from south-western Germany with 9 heterozygous carriers of haemoglobin E (beta 26 Glu-Lys) is presented. The abnormal haemoglobin has been identified by different electrophoretic techniques and fingerprint analysis. In contrast to earlier observations, haemoglobin E is even in heterozygous carriers associated with erythrocytic hypochromia with MCH values from 23.6 to 26.2 pg. As an explanation for the hypochromia a decreased haemoglobin synthesis is supposed.
D000328:Adult; D001797:Blood Protein Electrophoresis; D002648:Child; D004912:Erythrocytes / Q000032:analysis; D005260:Female; D006446:Hemoglobin E / Q000032:analysis; D006453:Hemoglobinopathies / Q000235:genetics*; D006455:Hemoglobins, Abnormal / Q000032:analysis; D006579:Heterozygote; D006801:Humans; D008297:Male; D008875:Middle Aged
D006455:Hemoglobins, Abnormal; D006446:Hemoglobin E
Hypocromie der Erythrozyten bei heterozygotem Hämoglobin E (beta 26 Glu replaced by Lys)