title: An unusual mouse myeloma protein binding native DNA.
abstract: SP 104 is an IgA-kappa myeloma protein produced by a lymphoid tumour of CA F1 mice. It arose originally in mice injected intraperitoneally with cell-free extract of spleen from a dog with systemic lupus erythematosus. The monoclonal nature of the IgA was shown by characteristic appearance on immunoelectrophoresis, restriction to a single light chain type and ability to induce anti-idiotypic antiserum. This protein has antibody activity against native (double-stranded) DNA and its specificity is similar to the antibodies against DNA found in the sera of humans with SLE and NZB/NZW F1 mice. Its idiotype does not cross-react with idiotypes of other mouse myeloma proteins known to bind DNA.
mesh_terms: D000818:Animals; D000906:Antibodies; D000918:Antibody Specificity; D003429:Cross Reactions; D004247:DNA / Q000276:immunology*; D005260:Female; D007122:Immunoelectrophoresis; D007070:Immunoglobulin A; D007145:Immunoglobulin kappa-Chains; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D051379:Mice; D008814:Mice, Inbred NZB; D009101:Multiple Myeloma / Q000276:immunology; D009194:Myeloma Proteins; D009374:Neoplasms, Experimental / Q000276:immunology; D009711:Nucleotides / Q000276:immunology; D010954:Plasmacytoma / Q000276:immunology; D011485:Protein Binding
chemical_list: D000906:Antibodies; D007070:Immunoglobulin A; D007145:Immunoglobulin kappa-Chains; D009194:Myeloma Proteins; D009711:Nucleotides; D004247:DNA