An abnormal Cgamma 4 gene among the negro population.
An analysis of the IgG4-CH3 antigenic determinants by means of specific antisera using a hemagglutination-inhibition procedure among different populations has been done. Thus 3.67% of sera from Negroids have been found completely deficient in normal IgG4 subclass. Sera without normal IgG4 contained the other IgG subclasses. Family studies shown the transmission of an abnormal Cgamma 4 gene. Hypothesis of gene deletion, point mutation or gene hybridization were postulated. This last hypothesis seems the most valuable.
D000349:Africa; D044383:Black People; D005826:Genetics, Medical; D006801:Humans; D007074:Immunoglobulin G; D007143:Immunoglobulin Heavy Chains; D007142:Immunoglobulin gamma-Chains; D010375:Pedigree; D014900:West Indies
D007074:Immunoglobulin G; D007143:Immunoglobulin Heavy Chains; D007142:Immunoglobulin gamma-Chains