[Complex formation between monoclonal IgM and albumin in a patient with macroglobulinaemia (author's transl)].
A remarkable interaction between a monoclonal IgM(x) protein and autologous albumin was found in the serum of a 76 year old male patient (Ke.E) without morphological characteristics of Waldenströms disease. The components were bound noncovalently. Immunoelectrophoretic analysis of 50 additional monoclonal IgM and 10 IgA sera showed a complex formation with albumin in 62% (IgM) and in 90% (IgA). The degree of interaction was, however, less pronounced in comparison with that observed in the serum of Ke.E.
D000368:Aged; D000936:Antigen-Antibody Complex; D006801:Humans; D006942:Hypergammaglobulinemia / Q000097:blood*; D007122:Immunoelectrophoresis; D007070:Immunoglobulin A; D007147:Immunoglobulin Light Chains; D007075:Immunoglobulin M / Q000032:analysis; D007145:Immunoglobulin kappa-Chains; D008297:Male; D010266:Paraproteins / Q000032:analysis; D012709:Serum Albumin / Q000032:analysis
D000936:Antigen-Antibody Complex; D007070:Immunoglobulin A; D007147:Immunoglobulin Light Chains; D007075:Immunoglobulin M; D007145:Immunoglobulin kappa-Chains; D010266:Paraproteins; D012709:Serum Albumin
Stark ausgeprägte IgM-albumin-Komplexbildung bei monoklonaler IgM-gammopathie