Some phenolic metabolites of 2, 4-diaminotoluene in the rabbit, rat and guinea-pig.
1. After administration of 2,4-diaminotoluene to rabbits, rats and guinea-pigs, phenolic metabolites are excreted, the major component being 5-hydroxy-2,4-diaminotoluene in all species investigated. Acetylated aminophenols and glucuronide conjugates were also found. 2. Rabbits, which produced the largest amounts of free amino-phenols, also had the highest levels of methaemoglobin in vivo.
D000818:Animals; D002855:Chromatography, Thin Layer; D005260:Female; D005965:Glucuronates / Q000652:urine; D006168:Guinea Pigs; D000882:Haplorhini; D010634:Phenobarbital / Q000494:pharmacology; D010636:Phenols / Q000378:metabolism*; D010655:Phenylenediamines / Q000378:metabolism*; D011817:Rabbits; D013045:Species Specificity; D013997:Time Factors
D005965:Glucuronates; D010636:Phenols; D010655:Phenylenediamines; C010914:2,4-diaminotoluene; D010634:Phenobarbital