Priming of Macaca cynomolgus philippinensis with purified antigen of Brucella melitensis before injection of Rev. I vaccine.
In experiments designed for study of bacteremia and serologic response of Macaca cynomolgus philippinensis to vaccination with a soluble antigen (fraction I) of Brucella melitensis and the live Rev. I vaccine strain, fraction I and Rev. I were administered both four weeks apart and simultaneously. One of three monkeys given the vaccines four weeks apart and two of three monkeys vaccinated with fraction I and Rev. I in a single injection developed transient bacteremia, as shown by blood cultures. Both methods of vaccination induced significant titers of antibody to B. melitensis, and vaccinated monkeys were protected against subsequent challenge with a virulent strain of B. melitensis.
D000818:Animals; D000917:Antibody Formation; D000942:Antigens, Bacterial; D002002:Brucella / Q000276:immunology*; D002004:Brucella Vaccine; D002006:Brucellosis / Q000517:prevention & control*; D000882:Haplorhini; D008251:Macaca / Q000276:immunology*; D008252:Macaca fascicularis / Q000276:immunology*; D018805:Sepsis
D000942:Antigens, Bacterial; D002004:Brucella Vaccine