title: Effects of tranylcypromine stereoisomers, clorgyline and deprenyl on open field activity during long term lithium administration in rats.
abstract: Locomotor activity of male rats was studied in an open field after an i.p. injection (15 mg/kg) of the d- or l-isomers of tranylcypromine (d-Tc and l-Tc, respectively) or after s.c. injection of either clorgyline (0.5, 1 or 5 mg/kg) which selectively inhibits Type A MAO or deprenyl (0.5, 5 or 10 mg/kg) which selectively inhibits Type B MAO. The rats were fed a diet containing either no lithium (control group) or lithium chloride (lithium group) for at least 28 days prior to tests. In the control group, d-Tc increased ambulation while l-Tc, deprenyl and clorgyline failed to affect activity. In the lithium group, d-Tc and deprenyl increased ambulation, l-Tc increased ambulation and rearing, while clorgyline failed to affect activity. Lithium appeared to potentiate the behavioral effects of deprenyl and l-Tc. Symptoms of serotonin-dependent hyperactivity appeared in the control group and lithium group given d-Tc. The role of biogenic amines in the effects of the drugs on open field activity is discussed.
mesh_terms: D000818:Animals; D003010:Clorgyline / Q000494:pharmacology; D004347:Drug Interactions; D008094:Lithium / Q000494:pharmacology*; D008297:Male; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects*; D010627:Phenethylamines / Q000494:pharmacology; D051381:Rats; D013237:Stereoisomerism; D014191:Tranylcypromine / Q000494:pharmacology
chemical_list: D008996:Monoamine Oxidase Inhibitors; D010627:Phenethylamines; D014191:Tranylcypromine; D008094:Lithium; D003010:Clorgyline