Reduced cerebrospinal fluid 5-hydroxyindoleacetic acid and homovanillic acid in children with epilepsy.
Cerebrospinal fluid (CSF) concentrations of 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA) and probenecid were examined in 14 children with epilepsy (ages 6 months to 17 years) and 17 controls (ages 14 months to 16 years). The concentrations of amine metabolites were significantly correlated with probenecid concentrations in both groups of children. Cerebrospinal fluid concentrations of 5-HIAA were 63.6 ng per milliliter plus or minus 8.23 S.E.M. and 117 ng per milliliter plus or minus 11.6 S.E.M. for the epilepsy and control groups respectively. HVA averaged 89.1 ng per milliliter plus or minus 15.2 S.E.M in epilepsy and 172 ng per milliliter plus or minus 19.2 S.E.M. in the control group. These findings indicate a significant difference between epilepsy and control groups. Probenecid concentrations were similar in each group. The reduced cerebrospinal fluid amine metabolite concentrations in children with epilepsy were not related to age, anticonvulsant medication, cerebrospinal fluid folate or protein concentration, or cerebrospinal fluid cell count. Our findings suggest a relationship between brain amines and epilepsy.
D000086:Acetazolamide / Q000008:administration & dosage / Q000627:therapeutic use; D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D004827:Epilepsy / Q000134:cerebrospinal fluid* / Q000188:drug therapy; D004833:Epilepsy, Temporal Lobe / Q000134:cerebrospinal fluid; D004830:Epilepsy, Tonic-Clonic / Q000134:cerebrospinal fluid; D005260:Female; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid*; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid*; D007223:Infant; D008297:Male; D010634:Phenobarbital / Q000008:administration & dosage / Q000134:cerebrospinal fluid / Q000627:therapeutic use; D010648:Phenylacetates / Q000134:cerebrospinal fluid*; D010672:Phenytoin / Q000008:administration & dosage / Q000134:cerebrospinal fluid / Q000627:therapeutic use; D011324:Primidone / Q000008:administration & dosage / Q000627:therapeutic use; D011339:Probenecid / Q000134:cerebrospinal fluid
D010648:Phenylacetates; D011324:Primidone; D006897:Hydroxyindoleacetic Acid; D010672:Phenytoin; D000086:Acetazolamide; D011339:Probenecid; D006719:Homovanillic Acid; D010634:Phenobarbital