title: Therapy of infections with cefazolin.
abstract: 16 patients with acute urinary tract infections, 6 with acute lower respiratory tract infections and 3 with miscellaneous infections were treated with 1 g cefazolin parenterally 3 times daily. All patients, except one in whom therapy was discontinued, were cured. Both intramuscular and intravenous administration resulted in high-peak serum levels, and concentrations after 8 h were still inhibitory to relevant pathogens. The drug was well tolerated and caused, after intramuscular injection, probably less pain than does cephalotin. Cefazolin is a rational choice of therapy in severe cases of acute urinary, respiratory, and other infections.
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000818:Animals; D002415:Cats; D002437:Cefazolin / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use*; D002511:Cephalosporins / Q000008:administration & dosage* / Q000627:therapeutic use*; D002648:Child; D004341:Drug Evaluation; D004926:Escherichia coli / Q000302:isolation & purification; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D007709:Klebsiella / Q000302:isolation & purification; D008297:Male; D008875:Middle Aged; D009343:Neisseria / Q000302:isolation & purification; D011511:Proteus / Q000302:isolation & purification; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification; D012141:Respiratory Tract Infections / Q000188:drug therapy* / Q000382:microbiology; D013211:Staphylococcus aureus / Q000302:isolation & purification; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D002511:Cephalosporins; D002437:Cefazolin