Nonspecific immunodepression induced by tumor-cell extracts.
The immunodepression induced by tumor extracts in these experiments is characterized by the severe impairement of cell-mediated immunity meaning an alteration of T-cell or macrophage functions or both. This depression is specific to tumor cells and is observed with normal tissue extracts. This model is different from that observed with Ehrlich ascites (7) where the function of the B cells is impaired. The transmission of the immunodepression by thymus-cell or liver-cell extracts of treated mice rules out the involvement of factors like those described by PIKOVSKI (11) and YAMAZAKI (16). On the other hand, the role of suppressor cells in the etiology of the immuno-suppression (5.9) cannot be completely eliminated.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology; D006084:Graft Rejection; D007111:Immunity, Cellular; D007165:Immunosuppression Therapy; D007942:Leukemia, Experimental / Q000139:chemically induced; D008213:Lymphocyte Activation; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D015127:9,10-Dimethyl-1,2-benzanthracene