[Clinical aspects of pathogenesis of alcohol embryopathy (author's transl)].
68 cases of alcohol embryopathy are reported. The main symptoms are intrauterine and postnatal growth retardation (91%), microcephaly (87 per cent), psychomotor and mental retardation (84 per cent) and a typical craniofacial dysmorphism. Other malformations are frequently found such as cardiac defects (31 per cent), anomalies of joints (23 per cent) and genitalia (50 per cent). There is a marked variation in the intensity of the malformations. Taking into account the extent of the craniofacial dysmorphism and the cerebral damage, a classification into three types (I-111) of alcohol embryopathy is proposed. That ethanol has a teratogenic effect seems to be confirmed. The mother's clinical history suggests that the quantity of alcohol consumed has no marked influence on birth weight, length of gestation and severity of the symptoms. Possibly a defective ethanol metabolism in the severely affected mothers may account for the dysplasias.
D000014:Abnormalities, Drug-Induced; D000437:Alcoholism / Q000150:complications*; D001724:Birth Weight / Q000187:drug effects; D001827:Body Height / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000008:administration & dosage / Q000009:adverse effects / Q000378:metabolism; D005260:Female; D005315:Fetal Diseases / Q000139:chemically induced*; D006130:Growth Disorders / Q000139:chemically induced; D006330:Heart Defects, Congenital / Q000139:chemically induced; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008607:Intellectual Disability / Q000139:chemically induced; D008297:Male; D008431:Maternal-Fetal Exchange; D008831:Microcephaly / Q000139:chemically induced; D011247:Pregnancy; D011248:Pregnancy Complications
D000431:Ethanol
Zur Klinik und Pathogenese der Alkohol-Embryopathie. Bericht über 68 Fälle.