Mesenchyme-dependent morphogenesis and epithelium-specific cytodifferentiation in mouse mammary gland.
Isografts of heterotypic recombinants of embryonic mammary epithelium with salivary mesenchyme undergo development morphogenetically resembling that of salivary gland. However, cytodifferentiation of the epithelium is like that of mammary gland. In lactating hosts these isografts respond to endogenous hormonal stimulation and synthesize a milk protein, alpha-lactalbumin.
D000818:Animals; D002454:Cell Differentiation; D004627:Embryonic Induction; D004847:Epithelial Cells; D005260:Female; D007768:Lactalbumin / Q000096:biosynthesis; D007774:Lactation; D007788:Lactose Synthase / Q000378:metabolism; D008321:Mammary Glands, Animal / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D008648:Mesoderm / Q000166:cytology; D051379:Mice; D008809:Mice, Inbred C3H; D009024:Morphogenesis; D011247:Pregnancy; D012469:Salivary Glands / Q000166:cytology
D007768:Lactalbumin; D007788:Lactose Synthase