[Immunological efficacy of live streptomycin-dependent salmonellae vaccines used orally in experiment on monkeys].
Experiments were conducted on 99 monkeys; a study was made of the reactogenic properties and the immunological efficacy of the streptomycin-dependent S. enteritidis and S. typhimurium mutants in oral application. The results of clinical, bacteriological, pathomorphological and fluorescent-serological studies demonstrated that the vaccines in the doses under study were areactogenic for monkeys in 5-fold oral administration and promoted development of marked immunity. The greatest immunizing effect was obtained in 5-fold oral vaccination with the subsequent three-fold (in 2 months) revaccination of the monkeys. Associated streptomyqin-dependent S. enteritidis and S. typhimurium vaccine could be used for prophylaxis of salmonellosis in monkeys.
D000284:Administration, Oral; D000818:Animals; D001428:Bacterial Vaccines / Q000008:administration & dosage; D000882:Haplorhini; D007114:Immunization; D007117:Immunization, Secondary; D009154:Mutation; D012480:Salmonella Infections / Q000517:prevention & control*; D012477:Salmonella enteritidis / Q000276:immunology* / Q000378:metabolism; D012486:Salmonella typhimurium / Q000276:immunology* / Q000378:metabolism; D013307:Streptomycin / Q000378:metabolism
D001428:Bacterial Vaccines; D013307:Streptomycin
Immunologicheskaia éffektivnost' zhivnykh streptomitsinzavisimykh sal'monelleznykh vaktsin pri peroral'nom primenenii v éksperimente na obez'ianakh