title: The effect of adrenergic system on glycogen synthetase activity in myocardium and skeletal muscle.
abstract: The activity of glycogen synthetase after in vivo stimulation and blockade of adrenergic receptors was determined in myocardium and skeletal muscle. Stimulation of alpha-adrenergic receptor by means of phenylephrine was found to increase the activity of synthetase form I both in the heart and skeletal muscle. Isoprenaline decreases the synthetase form I activity in both muscles under study by stimulation of beta-adrenergic receptor. Adrenaline alone or administered after alpha-adrenergic receptor blockade by phenoxybenzamine acts similarly as isoprenaline. These are data at disposal that stimulation of alpha-adrenergic receptor produces in myocardium and skeletal muscle cells the changes responsible for the increase of anabolic processes in glycogen metabolism.
mesh_terms: D000818:Animals; D004347:Drug Interactions; D004837:Epinephrine / Q000494:pharmacology; D006006:Glycogen Synthase / Q000378:metabolism*; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009132:Muscles / Q000201:enzymology*; D009206:Myocardium / Q000201:enzymology*; D009638:Norepinephrine / Q000494:pharmacology; D010643:Phenoxybenzamine / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D051381:Rats; D013566:Sympathomimetics / Q000494:pharmacology*
chemical_list: D013566:Sympathomimetics; D010643:Phenoxybenzamine; D010656:Phenylephrine; D006006:Glycogen Synthase; D007545:Isoproterenol; D009638:Norepinephrine; D004837:Epinephrine