Immunoglobulin M in human amniotic fluid and its possible association with neural-tube malformations.
Immunoglobulin M (IgM) was found in the amniotic fluid from two fetuses with neural tube defects but no in that from normal fetuses. The possible associations of IgM with abnormalities of the central nervous system are discussed.
D000418:Albumins / Q000032:analysis; D000653:Amniotic Fluid / Q000276:immunology*; D000937:Antigen-Antibody Reactions; D002490:Central Nervous System / Q000002:abnormalities*; D005260:Female; D006801:Humans; D005779:Immunodiffusion; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000276:immunology*; D008259:Macroglobulins / Q000032:analysis; D011247:Pregnancy; D016135:Spinal Dysraphism / Q000276:immunology
D000418:Albumins; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008259:Macroglobulins