Clinicopathological validation of a primate stroke model.
A method recently developed in our laboratory has been evaluated for clinical and pathological reliability and validity. Intracarotid injection of a silicone polymer molded into an elastic cylinder regularly caused segmental occlusion of the middle cerebral artery in sedated but conscious rhesus monleys. Clinical changes were quantitatively monitored continuously from onset through acute and chronic phases and precise correlations made with postmortem vascular and parenchymal pathology. Minor anatomical variations in the size and branching patterns of the middle cerebral artery in this primate species paralleled those in man. Uniformity in patterns of the acute natural history and specificity in clinical pathological correlations substantiate the utility of this stroke model for tests of therapeutic efficacy.
D000768:Anesthesia, General; D000818:Animals; D001921:Brain / Q000473:pathology; D002536:Cerebral Arteries; D002561:Cerebrovascular Disorders / Q000175:diagnosis / Q000473:pathology; D004195:Disease Models, Animal; D004569:Electroencephalography; D000882:Haplorhini; D007649:Ketamine; D008251:Macaca; D008253:Macaca mulatta
D007649:Ketamine