Excretion of guanidino-derivates in urine of hyperargininemic patients.
Quantitative determinations were made for seven guanidino-derivates in urine of patients affected with hyperargininemia, lysine cystinuria, healthy children and adults, goats and monkey. The amount of all seven guanidino-derivates excreted in the urine with the exception of guanidino-succinic acid was large in the case of hyperargininemic patients. Guanidino-succinic acid is found in traces in the urine of these patients, even after arginine loading tests. There is apparently no similarity concerning the guanidino-derivates between the patients with hyperargininemia, a pathological status, and the arginase deficiency in goats and monkeys, a physiological phenomenon.
D000328:Adult; D000818:Animals; D001120:Arginine / Q000097:blood / Q000378:metabolism*; D002648:Child; D005260:Female; D006041:Goats; D006146:Guanidines / Q000652:urine*; D000882:Haplorhini; D006801:Humans; D020162:Hyperargininemia; D008297:Male; D008661:Metabolism, Inborn Errors / Q000235:genetics*; D013045:Species Specificity
D006146:Guanidines; D001120:Arginine