In vitro studies with sisomicin and gentamicin.
Sisomicin and gentamicin were tested in vitro against 222 clinical isolates of pathogenic bacteria using the ICS agar dilution procedure. The two drugs were comparable in terms of overall activity although statistical analyses of the data revealed significant differences in their activity against several genera. Sisomicin was significantly more active against Pseudomonas aeruginosa (p less than 0.001), Proteus mirabilis (p less than 0.005), and Escherichia coli (p less than 0.01); gentamicin was significantly more active against Klebsiella (p less than 0.001). In most instances, 4.0 mug/ml of either drug was inhibitory for 90% or more of the isolates of each genus tested.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D004352:Drug Resistance, Microbial; D004755:Enterobacteriaceae / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D005839:Gentamicins / Q000494:pharmacology*; D007709:Klebsiella / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011513:Proteus mirabilis / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012705:Serratia / Q000187:drug effects; D012853:Sisomicin / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects; D013291:Streptococcus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D012853:Sisomicin