Carcinoma of the oral tongue and floor of mouth: fifteen years' experience with  linear acceleration therapy.
One hundred fourteen patients with carcinoma of the oral tongue and floor of mouth were treated with high-dose megavoltage radiation at Stanford University from 1956 to1970.  Actuarial 5-year survival for 56 patients with oral tongue lesions was: T', 73; T', 37%; and T', 19%.  Similarly, for 58 patients with lesions of the floor mouth, 5-year survival was: T', 73%; T', 37%; and T', 25%.  Local control of the primary was obtained in oral tongue T' lesions 10 of 11 times; T', 5 of 8; and T', 13 of 36 times.  For floor of mouth, local control was: T', 22 of 26;T', 7 of 14; andT', 3 of 15.  There was an indication that better control was obtained if interstitialtherapy was a planned part of the treatment.  Dose for local control when external radiation alone was utilized was usually over 1900 rets.  Patients with initially clinicallynegative nodes (TXNO) who had a low radiation dose to primary echelon lymph nodes developed later cervical lymph node metastases 38% of the time.  In no case did late metastatic disease appear in patients whose necks were treated prophylactically.
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000401:mortality / Q000532:radiotherapy*; D009362:Neoplasm Metastasis; D010025:Osteoradionecrosis; D011879:Radiotherapy Dosage; D011882:Radiotherapy, High-Energy / Q000009:adverse effects; D014062:Tongue Neoplasms / Q000401:mortality / Q000532:radiotherapy*