The effects of jaundiced plasma and hypercholesterolaemic plasma on vascular sensitivity to injected noradrenaline.
Jaundiced plasma and plasma from hyperlipidaemic patients was perfused into an isolated artery or kidney preparation. The responses of the artery to doses of noradrenaline when Krebs solution was perfused were compared to the responses when the plasmas were perfused. It was found that both jaundiced and hyperlipidaemic plasmas potentiated the effects of noradrenaline on the isolated arteries and kidneys.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005263:Femoral Artery / Q000187:drug effects*; D000882:Haplorhini; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood*; D066298:In Vitro Techniques; D007565:Jaundice / Q000097:blood*; D007668:Kidney / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology*; D010215:Papio; D011312:Pressure; D011817:Rabbits
D009638:Norepinephrine