[Behaviour of serum concentrations of glucose, immunoreactive insulin and potassium ions in newborns after long term or crash treatments with Partusisten or Partusisten in combination with Isoptin (author's transl)].
The investigation was done on 50 infants born of metabolic healthy mothers. A group of 10 women received short term treatment with Partusisten and Isoptin. Another 10 were treated over the same period with Partusisten only. A further group of 15 received long term treatment (more than 7 days) with Partusisten and Isoptin and a final group of 15 mothers received placebos. Serum concentrations of glucose, immunoreactive insulin and potassium, together with acid-base-status and other important blood chemistry were determined in mothers and newborns directly postpartum. Blood sugar, immunoreactive insulin and potassium were further determined in the newborns 30 minutes, 60 minutes, 2 hours and 6 hours after birth. The results showed that a temporary relative hypoglycaemia occured in the newborns in short term as well as long term treatment with Partusisten or Partusisten in combination with Isoptin. Temporary derangements in insulin-glucose equilibrium were also seen in newborns from mothers receiving long term treatment. It was also demonstrated that approximately 1 hour post-partum, blood sugar and immunoreactive insulin of the newborn attained values compatible with normal carbohydrate metabolism. From these results it is indicated that infants born of mothers, who received tocolytic treatments with Partusisten or Partusisten in combination with Isoptin, should be given sodiumbicarbonate and glucose directly after birth.
D000137:Acid-Base Imbalance / Q000139:chemically induced; D000138:Acidosis / Q000517:prevention & control; D001786:Blood Glucose / Q000378:metabolism*; D004983:Ethanolamines / Q000494:pharmacology*; D005260:Female; D005280:Fenoterol / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D006019:Glycolysis / Q000187:drug effects; D006801:Humans; D007003:Hypoglycemia / Q000517:prevention & control; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000517:prevention & control; D007328:Insulin / Q000097:blood*; D008134:Long-Term Care; D008431:Maternal-Fetal Exchange; D007752:Obstetric Labor, Premature / Q000517:prevention & control; D011188:Potassium / Q000097:blood*; D011247:Pregnancy; D014700:Verapamil / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use
D001786:Blood Glucose; D004983:Ethanolamines; D007328:Insulin; D005280:Fenoterol; D014700:Verapamil; D011188:Potassium
Zeitlicher Verlauf der Blutglukose, des immunoreaktiven Insulins und der Kaliumionen beim Neugeborenen nach Iangzeitiger und akuter Gabe von Partusisten mit und ohne Isoptin