Mixed IgG-IgA cryoglobulinemia in human serum sickness. Evidence for Equine IgG in the cryoprecipitate.
Serum sickness followed the administration of anti-lymphocyte globulin to a patient with multiple sclerosis. In addition to other characteristic features of this syndrome, there was hypocomplementemia and transient renal dysfunction similar to that observed in the 'one-shot' experimental model of serum sickness. Cryoglobulinemia was transiently demonstrable at the height of the inflammatory response. Analysis of the purified cryoprecipitate revealed the presence of human IgG and IgA, and, in addition, equine IgG. This demonstration of a well-defined exagenous antigen in the cryoprecipitate provides further support for the immune complex nature of mixed cryoglobulins.
D000328:Adult; D000818:Animals; D000961:Antilymphocyte Serum / Q000627:therapeutic use; D003176:Complement C3 / Q000032:analysis; D003450:Cryoglobulins / Q000032:analysis; D004155:Diphenhydramine / Q000627:therapeutic use; D006461:Hemolysis; D006736:Horses / Q000276:immunology; D006801:Humans; D007106:Immune Sera; D005779:Immunodiffusion; D007070:Immunoglobulin A / Q000032:analysis*; D007074:Immunoglobulin G / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis; D007167:Immunotherapy; D008297:Male; D009103:Multiple Sclerosis / Q000628:therapy; D009120:Muscle Cramp / Q000188:drug therapy; D011507:Proteinuria / Q000209:etiology; D011817:Rabbits / Q000276:immunology; D012217:Rheumatoid Factor / Q000032:analysis; D012713:Serum Sickness / Q000276:immunology*; D016038:Skin Transplantation; D014184:Transplantation, Homologous
D000961:Antilymphocyte Serum; D003176:Complement C3; D003450:Cryoglobulins; D007106:Immune Sera; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D004155:Diphenhydramine; D012217:Rheumatoid Factor