The induction of non-specific autoimmune phenomena by radiotherapy.
Induction of autoimmune phenomena by radiotherapy was evaluated with fluorescent antinuclear antibodies (FANA), latex fixation, and C'3 complement. 27 random serum samples obtained prior to radiotherapy revealed only a low C'3 in a patient with Hodgkin's disease and Sjögren's syndrome. 33 random serum samples obtained after radiotherapy revealed 7 positive values (5 FANA, 1 latex fixation, and 1 C'3). The increase in positive values was statistically significant.
D000974:Antibodies, Antinuclear / Q000032:analysis; D000917:Antibody Formation / Q000528:radiation effects*; D001323:Autoantibodies / Q000528:radiation effects; D003176:Complement C3 / Q000032:analysis; D003168:Complement Fixation Tests; D005455:Fluorescent Antibody Technique; D006801:Humans; D007109:Immunity / Q000528:radiation effects*; D005779:Immunodiffusion; D007841:Latex Fixation Tests; D011830:Radiation Effects; D011878:Radiotherapy / Q000009:adverse effects*; D011879:Radiotherapy Dosage; D012217:Rheumatoid Factor / Q000032:analysis
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D003176:Complement C3; D012217:Rheumatoid Factor