A mouse intracerebral infection with Neisseria gonorrhoeae.
An intracerebral challenge of HPB black mice with Neisseria gonorrhoeae is described. In this mode, the mice died from 1 to 6 days after challenge, and T1 organisms were obtained up to the fifth day from brain, liver, kidney, and spleen. Experimental gonococcal vaccines gave good protection against the challenge.
D000818:Animals; D001428:Bacterial Vaccines; D001921:Brain / Q000276:immunology / Q000382:microbiology; D001927:Brain Diseases / Q000382:microbiology*; D004195:Disease Models, Animal; D005260:Female; D006069:Gonorrhea / Q000276:immunology / Q000382:microbiology*; D007668:Kidney / Q000382:microbiology; D007928:Lethal Dose 50; D008099:Liver / Q000382:microbiology; D051379:Mice; D008815:Mice, Inbred Strains; D009344:Neisseria gonorrhoeae / Q000276:immunology / Q000302:isolation & purification / Q000472:pathogenicity*; D013154:Spleen / Q000382:microbiology; D014611:Vaccination; D014613:Vaccines, Attenuated
D001428:Bacterial Vaccines; D014613:Vaccines, Attenuated