[Pharmacology of a new cardiotropic drug : (dichloro-2, 3-methoxy 4) phenyl furyl-2-0-(diethylamino-ethyl)-ketone-oxime (ANP 4364)].
The (dichloro-2,3 methoxy 4) phenyl furyl-2 0-(diethylaminoethyl)-cetone-oxime (ANP 4364) is a powerful coronary vasodilator which lowers the resistance of large coronary arteries and decreases the O2 consumption of the myocardium. The activity of ANP 4364 is similar to digitalis: increase of cardiac flow, bradycardia, redistribution of the blood to peripheral area. These properties demonstrated in dogs have been confirmed in patients with cardiac diseases.
D000818:Animals; D001011:Aorta; D001572:Benzofurans / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects; D003864:Depression, Chemical; D004285:Dogs; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects; D013268:Stimulation, Chemical; D014655:Vascular Resistance / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology*; D014711:Vertebral Artery
D001572:Benzofurans; D014665:Vasodilator Agents
Pharmacologie d'un nouveau cardiotrope: le (dichloro-2,3 méthoxy 4) phényl furyl-2 0-(diéthylamino-éthyl)-cétone-oxime (ANP 4364)