[Hemodynamic effects after i.v. application of thyrotropin releasing factor (author's transl)].
20 patients and normal volunteers submitting to a right side heart catheterization have been subjected to hemodynamic tests before and after rapid i.v. injection of synthetic thyrotrophin releasing factor (TRF, Ro 08-6270). 10 persons among a first group were fully informed about the test, i.e. the exact time of injection, 10 others among a second group were not. A statistically significant rise of the arterial blood pressure and heart rate at an average 1-min interval after injection could be demonstrated. After 5 min the effect had completely vanished. The mean pulmonary arterial pressure like other hemodynamic parameters, the blood sugar and cholesterol did not change. A placebo-like effect could not be shown among a third group receiving only the added solvent. Because of the short interval after which the effect occurred, a determinant role of the hypothalamic-pituitary-thyroid feed back is very unlikely. A direct stimulus of TRF to smooth muscle cells of arterial walls responsible for vascular resistance in systemic vessels may be suggested as a hypothesis.
D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure / Q000187:drug effects*; D002784:Cholesterol / Q000097:blood; D002986:Clinical Trials as Topic; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D010919:Placebos; D011651:Pulmonary Artery / Q000502:physiology; D013973:Thyrotropin-Releasing Hormone / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D013997:Time Factors
D001786:Blood Glucose; D010919:Placebos; D013973:Thyrotropin-Releasing Hormone; D002784:Cholesterol
Hämodynamische Effekte nach intravenöser Applikation von Thyrotrophin Releasing Factor