[Inhibitory effect of ellipticine (dimethyl-5,11-(6H) pyrido (4,3-b) carbazole on the induction of liver cancer by BT6 (N,N-dimethyl-p-(benzothiazolylazo) analine) and its effect on the levels of cytochrome P450 and arginase activity].
Under the conditions of our tests, ellipticine inhibits remarkably the carcinogenic action of BT6 on the liver, characterized, in particular, by the swiftness of its outbreak. Under the influence of this carcinostatic compound, a considerable activation of liver metabolism is observed, resulting in an hyperproduction of cytochrome P450, while the arginase capital is restored after an appreciable fall, as if ellipticine played a favourable part in the safeguard of this enzyme, recognized as one of the targets of liver carcinogens. The relationships between various effects of ellipticine are discussed.
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D001119:Arginase / Q000378:metabolism*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004611:Ellipticines / Q000494:pharmacology*; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D009374:Neoplasms, Experimental / Q000473:pathology / Q000517:prevention & control; D051381:Rats; D013844:Thiazoles / Q000494:pharmacology; D013997:Time Factors; D004124:p-Dimethylaminoazobenzene / Q000031:analogs & derivatives* / Q000494:pharmacology
D000470:Alkaloids; D004611:Ellipticines; D013844:Thiazoles; D003577:Cytochrome P-450 Enzyme System; D004124:p-Dimethylaminoazobenzene; D001119:Arginase
Effet inhibiteur de l'ellipticine (diméthyl-5.11 (6H) pyrido (4.3-b) carbazole) sur la cancérisation du foie induite chez le rat par le BT6 (N, N-diméthyl-p-(6 benzothiazolylazo) aniline): ses incidences sur les taux de cytochrome P 450 et sur l'activité de l'arginase