[Sexual differences in the reaction of the thyroid gland and its sensitivity to thyrotropic hormone following administration of estradiol, testosterone and progesterone].
After the administration of estradiol benzoate (EB), testosterone propionate (TP) and progesterone (P)to Sprague-Dawley rats it was revealed that both the thyroid gland weight and the thyroxin-binding capacity of protein (TBCP) of the blood plasma were higher in the female than in the male animals. The female animals responsed to TP and P with lower values for total (TT4) and free thyrotoxin (T4)than the male animals. In the males EB elevated the level of TT4 and free T4, and in the females--the level of TT4 and TBCP. TP decreased the sensitivity of the thyroid gland to thyrotropic hormone. The stimulating effect of P on the thyroid gland resulted in its functional overstrain and exhaustion, which was stronger and more rapid in the female than in the male animals.
D000818:Animals; D004347:Drug Interactions; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D012739:Gonadal Steroid Hormones / Q000494:pharmacology*; D007455:Iodine / Q000378:metabolism; D008297:Male; D011374:Progesterone / Q000494:pharmacology; D012737:Sex Factors; D013739:Testosterone / Q000494:pharmacology; D013961:Thyroid Gland / Q000187:drug effects* / Q000378:metabolism; D013972:Thyrotropin / Q000494:pharmacology*; D013974:Thyroxine / Q000097:blood; D013975:Thyroxine-Binding Proteins / Q000378:metabolism
D012739:Gonadal Steroid Hormones; D013975:Thyroxine-Binding Proteins; D013739:Testosterone; D011374:Progesterone; D004958:Estradiol; D013972:Thyrotropin; D007455:Iodine; D013974:Thyroxine
Polovye razlichiia v reaktsii shchitovidnoĭ zhelezy i ee chuvstvitel'nosti k tireotropnomu gormonu posle vvedeniia éstradiola, testosterona i progesterona