title: The effects of transplacental and mammary movement of PCBs on infant rhesus monkeys.
abstract: Sixteen adult female rhesus monkeys were fed diets containing 2,5 and 5.0 ppm PCB (Aroclor 1248) for approx. 1.5 years. 6 of the 8 animals on 5 ppm PCB and 8 of the 8 animals on 2.5 ppm PCB conceived when bred after 6 months' exposure to PCB. Only 1 live infant was born to the animals of the 5.0 ppm group and 5 infants to the animals in the 2.5 ppm PCB group. All of the infants had PCBs in their tissues at birth. Thereafter, there was a rapid increase in the PCB levels of the infants' tissues. This increase was attributed to consumption of PCB-containing milk from their mothers. Within 2 months following birth the infants had facial acne and edema, swelling of the eyelids, loss of facial hair including eyelashes, and hyperpigmentation of the skin. Three of the 6 infants had expired within 8 months following birth due to PCB intoxication. The three survivors were weaned and subsequently showed marked improvement in their physical state.
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development; D001835:Body Weight / Q000187:drug effects; D005260:Female; D000882:Haplorhini; D007774:Lactation; D008253:Macaca mulatta; D008297:Male; D008321:Mammary Glands, Animal / Q000032:analysis*; D008431:Maternal-Fetal Exchange; D008892:Milk / Q000032:analysis*; D011078:Polychlorinated Biphenyls / Q000032:analysis / Q000506:poisoning / Q000633:toxicity*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D012867:Skin / Q000187:drug effects
chemical_list: D011078:Polychlorinated Biphenyls