Interval effect of beta-irradiation and subsequent 4-nitroquinoline 1-oxide painting on skin tumor induction in mice.
Skin tumors were produced in female ICR mice by 90Sr-90Y beta-irradiation and subsequent 4-nitroquinoline 1-oxide painting. The doses were chosen so as to produce no tumors with a single agent alone; the interval between two treatments ranged from 11 to 408 days. The tumor induction rate was found to be at almost the same level (average, 12.4%) for each interval. The results indicate the persistence of the latent carcinogenic alterations in the beta-irradiated mouse skin.
D015112:4-Nitroquinoline-1-oxide / Q000008:administration & dosage; D000287:Administration, Topical; D000818:Animals; D005260:Female; D051379:Mice; D008813:Mice, Inbred ICR; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009381:Neoplasms, Radiation-Induced; D009600:Nitroquinolines; D011830:Radiation Effects; D012867:Skin / Q000528:radiation effects; D012878:Skin Neoplasms / Q000139:chemically induced / Q000209:etiology*; D013326:Strontium Radioisotopes; D015021:Yttrium Radioisotopes
D009600:Nitroquinolines; D013326:Strontium Radioisotopes; D015021:Yttrium Radioisotopes; D015112:4-Nitroquinoline-1-oxide