Preparation of 6-(bromomethyl)-2,4-pteridinediamine hydrobromide and its use in improved syntheses of methotrexate and related compounds.
D001966:Bromine; D003959:Diamines / Q000138:chemical synthesis; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008722:Methods; D008727:Methotrexate / Q000138:chemical synthesis*; D008745:Methylation; D011621:Pteridines / Q000138:chemical synthesis*
D003959:Diamines; D007202:Indicators and Reagents; D011621:Pteridines; D001966:Bromine; D008727:Methotrexate