[On the acute respiratory infections of anaerobes bacteria: clinical, bacteriological and therapeutic results (author's transl)].
In order to isolate and identify aerobe and obligate anaerobe (O.A.) bacteria investigations were carried out on 11 patients with acute respiratory tract infections (7 of them severely ill and hospitalized in an Intensive Care Unit). O.A. species were isolated in 7 subjects, in all cases in mixed culture (from 2 to 5 species per sample), including also potentially pathogenic aerobe bacteria (Pseudomonas aeruginosa, Klebsiella pneumoniae, etc). On the 24 strains of O.A. bacteria identified, M.I.C. was determined for penicillin, clindamycin, chloramphenicol, and thiamphenciol. The data obtained have been compared with the M.I.C. of 28 strains isolated from uro-gynecological infections. The strains isolated from the respiratory tract presented a sensitivity spectrum to antibiotic similar to those isolated from the urogenital tract. Chloramphenicol and thiamphenicol inhibited growth in 100% of the cases at concentrations equivalent or inferior to plasma levels obtained with normal therapeutical doses; clindamycin was active at lower concentrations but not on all the strains isolated (3 Bacteroides, 1 Fusobacterium sp., 1 Peptococcus sp. were resistent). Penicillin G was active on 21 out of 25 Gram-positive strains, but only on 7 out 26 Gram-negative bacilli. In view of these results the difficulty of obtaining a correct etiologic diagnosis and the consequent use of a correct antibiotic therapy are discussed. The usefulness of the association of different antibiotics is suggested.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000693:Anaerobiosis; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects; D005260:Female; D006801:Humans; D007711:Klebsiella pneumoniae / Q000302:isolation & purification; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification; D012141:Respiratory Tract Infections / Q000188:drug therapy / Q000382:microbiology*
D000900:Anti-Bacterial Agents
Sulle infezioni respiratorie acute da anaerobi: rilievi clinici, batteriologici e terapeutici