Formaldehyde-ozone-induced fluorescence in gastrin-producing tumours.
Material from eight peptide hormone-secreting tumours, extirpated from the pancreas or from the antrum-duodenum region, was examined. Four of the patients had the clinical manifestations of the Zollinger-Ellison syndrome, two showed the features of an insulin-secreting tumour and one had a glucagonoma. Gastrin-producing cells, identified by immunohistochemistry, were found in five of the tumours. These cells displayed a varying degree of formaldehyde-ozone-induced fluorescence. This agrees with previous observations on the gastrin cell of human antral and duodenal mucosa. From model experiments, formaldehyde-ozone-induced fluorescence is thought to reflect the presence of peptides having tryptophan in the NH2-terminal position. The nature of this peptide in gastrin-producing cells is unknown.
D000328:Adult; D000368:Aged; D004379:Duodenal Neoplasms / Q000378:metabolism / Q000473:pathology; D005260:Female; D005453:Fluorescence; D005557:Formaldehyde; D005755:Gastrins / Q000378:metabolism; D005770:Gastrointestinal Neoplasms / Q000473:pathology*; D005934:Glucagon / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D008297:Male; D008875:Middle Aged; D010126:Ozone; D010190:Pancreatic Neoplasms / Q000378:metabolism / Q000473:pathology*; D013274:Stomach Neoplasms / Q000378:metabolism / Q000473:pathology; D014364:Tryptophan; D015043:Zollinger-Ellison Syndrome / Q000378:metabolism / Q000473:pathology
D005755:Gastrins; D007328:Insulin; D005557:Formaldehyde; D010126:Ozone; D014364:Tryptophan; D005934:Glucagon