Development of direct antiglobulin reaction accompanying alloimmunization in a patient with Rhd (D, category III) phenotype.
New examples of the Rhd (D, category III) red cell phenotype are described in three siblings. One of these individuals who had previously been transfused, received three units of Rho(D) positive blood several years later and developed a high titer anti-RhD antibody. This anamnestic response was associated with the development of an autoantibody which persisted for a period of at least 8 months. This observation represents another example of autoimmunization which has rarely been observed to accompnay alloimmunization.
D000328:Adult; D000743:Anemia, Hemolytic / Q000188:drug therapy; D000917:Antibody Formation; D000936:Antigen-Antibody Complex; D000937:Antigen-Antibody Reactions; D001322:Autoanalysis; D001323:Autoantibodies / Q000032:analysis*; D003298:Coombs Test; D005260:Female; D006400:Hematocrit; D006801:Humans; D006842:Hydrocarbons, Brominated; D007044:Hysterectomy; D007114:Immunization; D007158:Immunologic Techniques; D007501:Iron / Q000627:therapeutic use; D007518:Isoantibodies / Q000032:analysis; D010641:Phenotype; D011073:Polyamines; D012204:Rh-Hr Blood-Group System; D065227:Transfusion Reaction
D000936:Antigen-Antibody Complex; D001323:Autoantibodies; D006842:Hydrocarbons, Brominated; D007518:Isoantibodies; D011073:Polyamines; D012204:Rh-Hr Blood-Group System; D007501:Iron