title: Genetic controls of meiotic recombination and somatic DNA metabolism in Drosophila melanogaster.
abstract: Recombination-defective meiotic mutants and mutagen-sensitive mutants of D. melanogaster have been examined for their effects on meiotic chromosome behavior, sensitivity to killing by mutagens, somatic chromosome integrity, and DNA repair processes. Several loci have been identified that specify functions that are necessary for both meiotic recombination and DNA repair processes, whereas mutants at combination and DNA repair processes, whereas mutants at other loci appear to be defective in only one pathway of DNA processing.
mesh_terms: D000818:Animals; D002875:Chromosomes / Q000378:metabolism; D004247:DNA / Q000378:metabolism*; D004260:DNA Repair; D004331:Drosophila melanogaster; D008040:Genetic Linkage; D008540:Meiosis; D008938:Mitosis; D009153:Mutagens; D009154:Mutation; D011995:Recombination, Genetic; D012730:Sex Chromosomes
chemical_list: D009153:Mutagens; D004247:DNA