Inhibition of Pseudomonas burn wound infection by mafenide dry foam.
The results of an in vivo evaluation of 8.5% mafenide dry foam are described. Using burned guinea pigs infected with Pseudomonas aeruginosa, mafenide was applied every 12 hr as the dry foam or as the commercially available ointment. After 156 hr of therapy with the medicated dosage forms, the previously infected areas did not demonstrate the presence of Pseudomonas. However, all nonmedicated, infected controls produced positive cultures. Both medicated dosage forms demonstrated equivalent efficacy in the inhibition of Pseudomonas on burn wounds.
D000287:Administration, Topical; D000818:Animals; D002056:Burns / Q000150:complications*; D005453:Fluorescence; D006168:Guinea Pigs; D008272:Mafenide / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D009824:Ointments; D011552:Pseudomonas Infections / Q000188:drug therapy* / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification; D013449:Sulfonamides / Q000627:therapeutic use*; D014946:Wound Infection / Q000188:drug therapy* / Q000382:microbiology
D009824:Ointments; D013449:Sulfonamides; D008272:Mafenide