[A case of Goldenhar syndrome: acute vitamin A intoxication in the mother during pregnancy].
The authors describe the case of a boy aged 2 1/2, who showed at birth a bilateral epibulbar dermoid, preauricular appendices on the left side and other malformations suggesting Goldenhar's syndrome. The history disclosed that in the second month of pregnancy the mother had accidentally swallowed 10 ml of an oily solution of Vitamin A during a laboratory manipulation. In their discussion, the autonrs analyse the teratogenic action of Vitamin A during embryonic development and review the aetiologies found in cases of Goldenhar's syndrome.
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000015:Abnormalities, Multiple / Q000139:chemically induced*; D001934:Branchial Region; D002675:Child, Preschool; D003884:Dermoid Cyst / Q000139:chemically induced*; D005124:Eye Abnormalities; D005145:Face / Q000002:abnormalities; D005260:Female; D006801:Humans; D008297:Male; D008342:Mandibulofacial Dysostosis / Q000139:chemically induced*; D011247:Pregnancy; D013577:Syndrome; D014801:Vitamin A / Q000009:adverse effects*
D014801:Vitamin A
A propos d'un das de syndrome de Goldenhar: intox;cation aiguë à la vitamine A chez la mère pendant la grossesse