Adjuvant effects of diethylaminoethyl-dextran.
Diethylaminoethyl-dextran exhibited a significant effect on the primary immune response of rhesus monkeys to formalin-inactivated Venezuelan equine encephalomyelitis virus vaccine (IVEE). Antibody formed to IVEE and adjuvant followed a classic immunoglobulin M-immunoglobulin G pattern; however, as compared with vaccine alone, use of this adjuvant with IVEE reduced the time required for onset of immunoglobulin G synthesis.
D000276:Adjuvants, Immunologic; D000818:Animals; D000914:Antibodies, Viral; D000917:Antibody Formation; D000956:Antigens, Viral; D003637:DEAE-Dextran / Q000276:immunology*; D003911:Dextrans / Q000031:analogs & derivatives*; D004666:Encephalitis Virus, Venezuelan Equine / Q000276:immunology*; D005260:Female; D000882:Haplorhini; D006462:Hemolytic Plaque Technique; D008297:Male; D014765:Viral Vaccines
D000276:Adjuvants, Immunologic; D000914:Antibodies, Viral; D000956:Antigens, Viral; D003911:Dextrans; D014765:Viral Vaccines; D003637:DEAE-Dextran