Thyroid-stimulating immunoglobulins and the control of thyroid function.
Triiodothyronine (T3) suppression and thyrotropin-releasing hormone (TRH) tests were used to study thyroid function in 50 patients with thyroid disease. The results of the thyroid function tests were compared with the levels of serum thyroid-stimulating immunoglobulins (TSI) measured by a radio-receptor assay. In euthyroid and hyperthyroid patients, the presence of TSI corresponded with the absence of TSH control of thyroid function. However, in two hypothyroid patients with serum TSI levels readily detectable in the receptor assay, T3 suppression and TRH tests indicated that thyroid function was under TSH control.
D000328:Adult; D001681:Biological Assay; D005260:Female; D006111:Graves Disease / Q000097:blood / Q000175:diagnosis*; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism*; D007457:Iodine Radioisotopes; D008297:Male; D011485:Protein Binding; D011863:Radioimmunoassay; D013667:Technetium; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000502:physiology*; D013972:Thyrotropin / Q000097:blood*; D013973:Thyrotropin-Releasing Hormone / Q000097:blood*; D014284:Triiodothyronine / Q000097:blood*
D007136:Immunoglobulins; D007457:Iodine Radioisotopes; D014284:Triiodothyronine; D013973:Thyrotropin-Releasing Hormone; D013667:Technetium; D013972:Thyrotropin