Biochemistry of malignant melanoma.
The biochemistry of malignant melanoma is reviewed. The biosynthesis of melanin from tyrosine is described and the role of tyrosinase and other enzymes in melanoma considered. Detailed methods for the assay of free catechols, their metabolites and urinary indole melanogens are included. Normal values for these constituents and their significance in the evaluation of melanoma patients are discussed.
D004156:Catechol Oxidase / Q000378:metabolism; D002396:Catechols / Q000032:analysis; D004295:Dihydroxyphenylalanine / Q000032:analysis; D006466:Hemopexin / Q000032:analysis; D006801:Humans; D007211:Indoles / Q000652:urine; D008543:Melanins / Q000096:biosynthesis; D008545:Melanoma / Q000175:diagnosis / Q000201:enzymology / Q000378:metabolism*; D014443:Tyrosine / Q000378:metabolism
D002396:Catechols; D007211:Indoles; D008543:Melanins; D014443:Tyrosine; D004295:Dihydroxyphenylalanine; D006466:Hemopexin; D004156:Catechol Oxidase