Biological activities of 17-phenyl-18,19,20-trinorprostaglandins.
In a number of assay systems, some 17-phenyl-trinor-prostaglandins were similar in activity and potency to the corresponding parent prostaglandin. In others, the 17-phenyl analogs appeared several times more potent. In the hamster antifertility assay, which is considered to measure luteolytic activity, 17-phenyl-18,19,20-trinor prostaglandin F2alpha was about 90-times PGF2alpha in potency. Rat blood pressure responses to 17-phenyl analogs were significant. The 17-phenyl-trinor PGF2alpha pressor potency was 5 times that of PGF2alpha. The 17-phenyl-trinor PGE2 blood pressure response was atypical since a pressor rebound phenomenon followed the expected depressor response. Lastly, 17-phenyl-trinor PGF2alpha was more potent than PGF2alpha in synchronizing the estrous cycle in beef cows.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002417:Cattle; D002462:Cell Membrane / Q000378:metabolism; D003106:Colon / Q000187:drug effects; D003338:Corpus Luteum / Q000187:drug effects; D006224:Cricetinae; D003864:Depression, Chemical; D004285:Dogs; D004971:Estrus / Q000187:drug effects; D005260:Female; D005298:Fertility / Q000187:drug effects; D005750:Gastric Juice / Q000378:metabolism; D005849:Gerbillinae; D000882:Haplorhini; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010088:Oxidoreductases / Q000378:metabolism; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D011453:Prostaglandins / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D012636:Secretory Rate / Q000187:drug effects; D013268:Stimulation, Chemical; D014599:Uterus / Q000187:drug effects
D011453:Prostaglandins; D011374:Progesterone; D010088:Oxidoreductases