The use of non-human primates for production of antisera to human tumor-associated antigens.
High-titered antisera against human melanoma- and leukemia-associated antigens have been produced in non-human primates. The data from this and from other studies suggest that this model may prove a valuable source of highly specific antisera against a variety of human tumor-associated antigens or alloantigens. Our methods for production and characterization of these antisera are reported.
D000818:Animals; D000912:Antibodies, Neoplasm / Q000032:analysis / Q000096:biosynthesis*; D000951:Antigens, Neoplasm / Q000032:analysis; D003601:Cytotoxicity Tests, Immunologic; D000882:Haplorhini / Q000276:immunology; D007938:Leukemia / Q000276:immunology; D008223:Lymphoma / Q000276:immunology; D008545:Melanoma / Q000276:immunology; D002679:Pan troglodytes / Q000276:immunology; D011323:Primates / Q000276:immunology*
D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm