Influence of parietal cell vagotomy and selective gastric vagotomy on gastric emptying rate and serum gastrin concentration.
Gastric emptying of a solid meal and serum gastrin concentration were studied in 26 patients with duodenal ulcer disease before and after parietal cell vagotomy (PCV), selective gastric vagotomy with drainage (SGV + D), or parietal cell vagotomy with drainage. PCV had no significant effect on gastric emptying rate, whereas emptying was significantly delayed after SGV + D. The integrated gastrin output 60 to 300 min after the test meal was insignificantly altered after PCV, but significantly increased after SGV + D. It is concluded that the drainage procedure did not normalize the disturbed gastric emptying after SGV. The prolonged hypergastrinemia period after food stimulation may reflect stasis.
D000328:Adult; D000368:Aged; D004381:Duodenal Ulcer / Q000601:surgery; D005260:Female; D005750:Gastric Juice / Q000378:metabolism; D005755:Gastrins / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013270:Stomach / Q000166:cytology / Q000502:physiology*; D014628:Vagotomy / Q000379:methods*
D005755:Gastrins