[Mechanism of inactivation and mutagenesis induced by ethyleneimine in Drosophila melanogaster germ cells. VI. Dominant lethal mutations at different stages of spermatogenesis].
The object of this investigation was the frequency of dominant lethal mutations (DLM) induced by ethylene imine (EI) in spermatozoa, spermatids, spermatocytes I and spermatogonia of Drosophila melanogaster. The DLM frequency was shown to increase up to a certain level in case of storage of EI-treated spermatozoa in spermathecas of intact females. No such increase of the DLM frequency was observed for treated spematids. No differences in the induced DLM frequency between treated spermatozoa and spermatids were observed. The treatment of spermatocytes I resulted in the sterility of males; however, after the elapse of some time their fertility was restored at the expense of dividing spermatozoa. The sterility of males in case of the EI treatment of spermatocytes I is presumably caused by a great number of chromosome aberrations. The data obtained are discussed from the standpoint of the hypothesis of potential chromosome lesions. The realization of these potential chromosome damages in the groups of cells studied is assumed to depend on the activity of the protein synthesis or of the metabolism in the cells. The more active is the chromosome, the more rapidly are realized the potential chromosome damages.
D000818:Animals; D001388:Aziridines; D004331:Drosophila melanogaster; D005799:Genes, Dominant; D005804:Genes, Lethal; D008297:Male; D009153:Mutagens; D009154:Mutation; D013094:Spermatozoa / Q000187:drug effects*
D001388:Aziridines; D009153:Mutagens
Izuchenie mekhanizma inaktivatsii i mutageneza pri deĭstvii étilenimina na polovye kletki Drosophila melanogaster. Soobshchenie VI. Dominantnye letal'nye mutatsii na raznykh stadiiakh spermatogeneza