title: 2-Phenethylimidazole derivatives. Synthesis and antimycotic properties.
abstract: Compounds of type (X = O, NH; Ar and Ar' = phenyl of substituted phenyl; ten examples) were prepared and assayed against miconazole (II,X = O; Ar = Ar' =2,4-Cl2C6H3) as potential antimycotic agents. Optimal activity was noted for I(X = O; Ar = Ar' = 2,4-Cl2C6H3), the direct analog of miconazole. It is about one-tenth as active.
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001232:Aspergillus fumigatus / Q000187:drug effects; D001234:Aspergillus niger / Q000187:drug effects; D001409:Bacillus cereus / Q000187:drug effects; D002175:Candida / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D013293:Enterococcus faecalis / Q000187:drug effects; D004821:Epidermophyton / Q000187:drug effects; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008864:Microsporum / Q000187:drug effects; D009168:Mycobacterium phlei / Q000187:drug effects; D010407:Penicillium / Q000187:drug effects; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D013210:Staphylococcus / Q000187:drug effects; D014249:Trichophyton / Q000187:drug effects
chemical_list: D000935:Antifungal Agents; D007093:Imidazoles