Cytolytic effects of the complement cleavage product, C3a.
Purified C3a, a cleavage product of the third component of complement,was incubated with various cell types of human and mouse origin. All the tumour cell types tested were lysed by low concentrations of C3a, whereas normal human lymphocytes were relatively resistant. No lysis was produced by C3 or C3b. The possible role of C3a in immunity against tumours is discussed.
D000818:Animals; D003176:Complement C3; D003165:Complement System Proteins; D003601:Cytotoxicity Tests, Immunologic; D008198:Lymph Nodes / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D012515:Mast-Cell Sarcoma / Q000276:immunology; D051379:Mice; D012709:Serum Albumin; D013696:Temperature; D013997:Time Factors
D003176:Complement C3; D012709:Serum Albumin; D003165:Complement System Proteins