[A search for viruses in systemic lupus erythematosis. Somatic fusion amoung mammalian cells using concanavalin A].
Attempts were made to isolate a virus from systemic lupus erythematosus patients, using lymphocyte cultures prepared from peripheral blood. Both cocultivation with VERO cells and fusion experiments in which lysolecithin and Concanavalin A were employed as fusing agents failed to reveal any presence of virus. Con A proved to be useful for heterokaryon formation in primate cells, fusion levels varying from 14-21% as shown by autoradiography.
D002459:Cell Fusion / Q000187:drug effects; D002460:Cell Line; D003208:Concanavalin A / Q000494:pharmacology; D003588:Cytopathogenic Effect, Viral; D008180:Lupus Erythematosus, Systemic / Q000382:microbiology*; D008214:Lymphocytes / Q000382:microbiology*
D003208:Concanavalin A
Recherche d'un virus dans le lupus érythémateux disséminé. Fusion somatique entre cellules de mammifères favorisée par la concanavaline A