[The effects of dihydroergo-corine,-cryptine and-cristine on Haemodynamics in experimental cardiogenic shock].
Experimental results demonstrate, that serial ligatures of the side brances of the anterior descending and circumflex artery in the openchest dog produce a hemodynamic and electrocardiographic criteria fullfilling cardiogrenic shock. The application of the alpha-receptor-blocking agens Hydergin is followed by a statistically significant increase of the mean aortic pressure, the left ventricular systolic pressure and the mean blood flow in the femoral artery. The left ventricular enddiastolic pressure in the left ventricular enddiastolic pressure in the left ventricle decreases statistically not significant, dp/dtmax is unchanged. Hydergin effects a slope of the increased peripheral vascular ristance; if the peripheral vascular risistance is lowered during cardiogenic shock, there will not be a further lowering after treatment. The results show, that Hydergin causes a dilation of peripheral vasoconstricted vessels without unwanted hemodynamic side effects.
D000818:Animals; D001013:Aorta, Thoracic; D001794:Blood Pressure; D001810:Blood Volume; D004088:Dihydroergotoxine / Q000627:therapeutic use*; D004285:Dogs; D004877:Ergoloid Mesylates / Q000627:therapeutic use*; D005263:Femoral Artery; D012770:Shock, Cardiogenic / Q000188:drug therapy*; D014665:Vasodilator Agents
D014665:Vasodilator Agents; D004088:Dihydroergotoxine; D004877:Ergoloid Mesylates
Einfluss von Dihydro-Ergocorinin,-Ergokryptin und-Ergocristin auf die Hämodynamik im experimentellen kardiogenen Schock