[Action of an antioxygen food additive, di-tertio-butyl-hydroxy-toluene on the electron transport and on the coupling of oxidation and phosphorylation in the liver mitochondria of rats].
BHT in vitro has a strong uncoupling effect on phosphorylating oxidations of hepatic mitochondria at concentrations less than or equal to 2.5.10(-4) M. On the contrary, no uncoupling is found after in vivo administration of 0.5% of BHT in rat diet. The differences between in vitro and in vivo results are discussed.
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D002084:Butylated Hydroxytoluene / Q000494:pharmacology*; D003408:Cresols / Q000494:pharmacology*; D004579:Electron Transport / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D013386:Succinates / Q000378:metabolism; D014475:Uncoupling Agents
D000975:Antioxidants; D003408:Cresols; D013386:Succinates; D014475:Uncoupling Agents; D002084:Butylated Hydroxytoluene
Action d'un additif alimentaire anti-oxygène, de di-tertio-butyl-hydroxy-toluène (BHT) sur le transport d'électrons et le couplage des oxydations et des phosphorylations dans les mitochondries de foie de rat