Erythroid and myeloid regeneration after nitrogen mustard therapy, autologous bone marrow transplantation, and treatment with an anabolic steroid.
Stumptailed monkeys (Macaca arctoides) received a lethal nitrogen mustard injection. Autologous bone marrow reinjection resulted in survival of the majority of animals. Treatment with an anabolic steroid accelerated erythropoietic and leukopoietic recovery. This appears to be related to increased erythropoietin production and increased number of colony forming units in the bone marrow.
D000818:Animals; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D002999:Clone Cells; D004920:Erythropoiesis; D004921:Erythropoietin / Q000096:biosynthesis*; D005260:Female; D000882:Haplorhini; D007275:Injections, Intravenous; D008251:Macaca; D008297:Male; D009277:Nandrolone / Q000008:administration & dosage / Q000627:therapeutic use*; D009588:Nitrogen Mustard Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D012038:Regeneration; D014182:Transplantation, Autologous
D009588:Nitrogen Mustard Compounds; D004921:Erythropoietin; D009277:Nandrolone