Biliary metabolites of 2,5,2',5'-tetrachlorobiphenyl in the rat.
Biliary metabolites of rats receiving 3H labeled 2,5,2',5'-tetrachlorobiphenyl, a component of commercial polychlorinated bipheyl (PCB) mixtures include 3-OH-2,5,2',5'-tetrachlorobiphenyl and a dihydrodiol tentatively identified as trans-3,4-dihydrodihydroxy-2,5,2',5'-tetrachlorobiphenyl. Metabolism of PCBs in the rat probably occurs in part through an arene oxide intermediate.
D000818:Animals; D001646:Bile / Q000378:metabolism*; D005260:Female; D006900:Hydroxylation; D008297:Male; D011078:Polychlorinated Biphenyls / Q000378:metabolism*; D051381:Rats; D013997:Time Factors
D011078:Polychlorinated Biphenyls