Retention of functional tolerance to ethanol in rhesus monkeys (Macaca mulatta).
Tolerance to ethanol (3 g/kg 90 min prior to testing) was assessed in a group of 4 rhesus monkeys in which tolerance development had been observed using the same behavioral task one year prior to the present study. Although some decrements in performance on a two-choice discrimination reversal learning task were observed, these changes were transient and statistically insignificant. Results indicate that functional tolerance persisted throughout a one year abstinence period.
D000818:Animals; D004192:Discrimination, Psychological / Q000187:drug effects; D004361:Drug Tolerance; D000431:Ethanol / Q000494:pharmacology; D005260:Female; D000882:Haplorhini; D008253:Macaca mulatta; D008297:Male; D011930:Reaction Time / Q000187:drug effects; D013997:Time Factors
D000431:Ethanol