[Availability of 14C-carbaryl after oral intake by pregnant rats].
After a single per os administration of an anticholinesterasic drug, 1-naphthyl-N-methyl 14C-carbamate to the pregnant Rat (18th day) we determine 14C activity from blood, liver, kidney, spleen, lung, brain, heart, placenta and foetus at intervals between 1 and 96 hrs. We compare membranous transfer of carbaryl metabolites. Hemato-encephalic diffusion is slow. Intestine and placental transfers are effective from the 1st hr. and of important value.
D000284:Administration, Oral; D000818:Animals; D001921:Brain / Q000378:metabolism; D012721:Carbaryl / Q000008:administration & dosage / Q000378:metabolism*; D005260:Female; D005333:Fetus; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008431:Maternal-Fetal Exchange; D009206:Myocardium / Q000378:metabolism; D009928:Organ Specificity; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D011270:Pregnancy, Animal; D051381:Rats; D013154:Spleen / Q000378:metabolism
D012721:Carbaryl
Biodisponibilité du 14C-carbaryl après administration orale à la ratte gestante