Serum IgE levels and reaginic-type skin reactions in sarcoidosis.
Immunoglobulin E (IgE) levels in sera of eighty-four patients with sarcoidosis and fifty-one apparently healthy controls were measured by means of a radioimmunosorbent test (RIST). A significant decrease in IgE level was commonly seen in patients with sarcoidosis. In some patients, a typical isolated IgE deficiency was noted. In a group of patients with significantly low serum IgE levels, reduced immune responsiveness affecting the IgE class was suggested from the study on reaginic-type skin reactions. The implication of these findings with respect to the immunology and etiology of sarcoidosis is discussed.
D000328:Adult; D000485:Allergens / Q000008:administration & dosage; D000906:Antibodies / Q000008:administration & dosage*; D000917:Antibody Formation; D005260:Female; D006801:Humans; D007106:Immune Sera / Q000008:administration & dosage; D005779:Immunodiffusion; D007070:Immunoglobulin A / Q000032:analysis; D007073:Immunoglobulin E / Q000032:analysis*; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007271:Injections, Intradermal; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D011935:Reagins / Q000008:administration & dosage*; D012507:Sarcoidosis / Q000276:immunology*; D012882:Skin Tests
D000485:Allergens; D000906:Antibodies; D007106:Immune Sera; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D011935:Reagins; D007073:Immunoglobulin E