The growth of some mycobacteria on cultured human tissues.
M. ulcerans grows in close association with the surface of cultured human foetal and adult tissue and produces necrosis. M. tuberculosis grows also but M. xenopi grows little or not at all. The two first named seem to stick well to the tissue surface and the last does not. These results are discussed in relationship to the pathogenesis of Buruli ulcer.
D000273:Adipose Tissue / Q000382:microbiology; D005333:Fetus / Q000382:microbiology; D007668:Kidney / Q000382:microbiology; D008168:Lung / Q000382:microbiology; D009132:Muscles / Q000382:microbiology; D009161:Mycobacterium / Q000254:growth & development*; D009164:Mycobacterium Infections / Q000150:complications; D009169:Mycobacterium tuberculosis / Q000254:growth & development*; D009336:Necrosis; D009924:Organ Culture Techniques; D012883:Skin Ulcer / Q000209:etiology; D013997:Time Factors