title: The influences of divalent metal ions on fibrin monomer polymerization.
abstract: This work was undertaken in an attempt to clarify the influences of divalent metal ions on the polymerization of fibrin monomer. Polymerization was strongly inhibited by such Ca-binding chelating agents as 1,2-cyclohexanediaminetetraacetic acid, ethylenediaminetetraacetic acid and glycoletherdiaminetetraacetic acid, and a close relationship was seen between their inhibitory capacity and their stability against Ca2+. The polymerization inhibited by ethylenediaminetetraacetic acid could not be reversed by the addition of Mg2+, Sr2+ or Ba2+, whose stability constants are smaller than that of Ca2+, but it could be completely reversed, and even directly accelerated by Zn2+, Cu2+, Cd2+ or Co2+ whose stability constants are greater than that of Ca2+.
mesh_terms: D001464:Barium; D001665:Binding Sites; D002104:Cadmium; D002118:Calcium; D002413:Cations, Divalent; D003035:Cobalt; D003300:Copper; D004355:Drug Stability; D004492:Edetic Acid; D005337:Fibrin; D007700:Kinetics; D046911:Macromolecular Substances; D008274:Magnesium; D011485:Protein Binding; D013324:Strontium; D015032:Zinc
chemical_list: D002413:Cations, Divalent; D046911:Macromolecular Substances; D002104:Cadmium; D001464:Barium; D003035:Cobalt; D003300:Copper; D005337:Fibrin; D004492:Edetic Acid; D008274:Magnesium; D015032:Zinc; D002118:Calcium; D013324:Strontium