Augmentation of thyrotropin responses to thyrotropin-releasing hormone following inorganic iodide.
Eight euthryoid subjects were administered 500 mug of thyrotropin-releasing hormone intravenously before and after the administration of 10 mg potassium iodide daily for 7 days. Basal serum concentrations of TSH and the response of TSH to TRH were significantly increased following iodide treatment, while serum levels of T4 and T3 did not differ significantly. It is suggested that the administration of 10 mg/day of potassium iodide can produce similar changes in serum TSH to those in previous reports using large doses of iodide.
D000328:Adult; D006801:Humans; D007454:Iodides / Q000494:pharmacology*; D008297:Male; D013268:Stimulation, Chemical; D013972:Thyrotropin / Q000097:blood*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*; D013974:Thyroxine / Q000097:blood
D007454:Iodides; D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin; D013974:Thyroxine