Clinico-pharmacological examination of gentamycin in thoracic surgery.
Authors describe the distribution and antibiogram of 185 microorganism strains cultured from thoracic surgical diseases. Gentamycin has been efficacious in the great majority of Gram negative pathoorganisms even in cases where other antibiotics were ineffective. In 14 cases they determined gentamycin concentration of serum and removed lung tissue between the 30th and 120th minutes after intramuscular application of 80 mg gentamycin. The serum level was 2.2 to 6.4 mcg/ml, 4.6 mcg/ml in average, the lung tissue level 0.4 to 3.0 mcg/g, 1.3 mcg/g on an average, the distribution quoteint 30 to 70%, 37% in average. 17 patients were locally treated by gentamycin because of thoracic surgical infections. In acute cases the results have been good, in chronic cases improvement has been achieved.
D000328:Adult; D000368:Aged; D005260:Female; D005839:Gentamicins / Q000032:analysis / Q000097:blood / Q000627:therapeutic use*; D006801:Humans; D007273:Injections, Intramuscular; D008168:Lung / Q000032:analysis; D008171:Lung Diseases / Q000601:surgery*; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D010996:Pleural Effusion / Q000032:analysis; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012141:Respiratory Tract Infections / Q000188:drug therapy*; D013211:Staphylococcus aureus / Q000187:drug effects; D013530:Surgical Wound Infection / Q000188:drug therapy*
D005839:Gentamicins