Failure of carbon monoxide to induce myocardial infarction in cholesterol-fed cynomolgus monkeys (Macaca fascicularis).
Twenty-six adult female cynomolgus monkeys (Macaca fascicularis) were randomly assigned to four groups which were fed on a standard laboratory diet or a semipurified diet containing cholesterol. In two of the groups, the monkeys were exposed intermittently to CO throughout the day for 14 months; the control animals breathed room air. No myocardial infarctions were observed, and the ECG showed a transitory injury current in only one animal. No differences in plasma cholesterol levels or in aortic and coronary atherosclerosis could be attributed to CO exposure.
D000818:Animals; D001011:Aorta / Q000473:pathology; D001161:Arteriosclerosis / Q000139:chemically induced / Q000473:pathology; D002248:Carbon Monoxide; D002791:Cholesterol, Dietary / Q000009:adverse effects*; D003331:Coronary Vessels / Q000473:pathology; D004195:Disease Models, Animal; D005260:Female; D000882:Haplorhini; D008252:Macaca fascicularis; D009203:Myocardial Infarction / Q000139:chemically induced*; D013997:Time Factors
D002791:Cholesterol, Dietary; D002248:Carbon Monoxide