Effect of quinaldic acid and its relatives on insulin-release from isolated Langerhans islets.
Influence of quinaldic acid on insulin release from isolated Langerhans islets of rats was studied. It was found that quinaldic acid by itself caused insulin release on the one hand and that it inhibited the second phase of glucose-induced insulin release on the other. A possible mechanism concerning the effect of quinaldic acid on beta-cells of Langerhans islets is presented.
D000818:Animals; D002264:Carboxylic Acids / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005947:Glucose / Q000494:pharmacology; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D011691:Puromycin / Q000494:pharmacology; D011804:Quinolines / Q000494:pharmacology*; D051381:Rats
D002264:Carboxylic Acids; D007328:Insulin; D011804:Quinolines; D011691:Puromycin; D005947:Glucose