[Transplacental blastomogenesis in mice under conditions of the detoxifying function of the mother's body].
The experiments on mice of line SHR have shown that in animals, delivered by Cesarean section I hour following intrauterine injection of 40 mg/Kg of DMBA in mothers (a period of maximum concentration of the carcinogen in the tissues of foetuses) and sacrificed one year later, carcinogenesis proceeded much more intensively than in mice, which after transplacental DMBA exposure continued their intrauterine development for 6 hours longer, i.e. till complete disintegration of DMBA. An enhancement of the transplacental carcinogenic effect was manifested in a reliable increase of the total frequency of the appearance of different neoplasms, in more frequent development of lung, ovary and mammary tumors, and also in the appearance of malignant lung tumors-adenocarcinomas. A considerable enhancement of the transplacental blastomogenic effect in these mice was due to exclusion of the detoxication function of the maternal organism.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000378:metabolism; D000818:Animals; D001551:Benz(a)Anthracenes; D001711:Biotransformation; D005260:Female; D008658:Inactivation, Metabolic; D008175:Lung Neoplasms / Q000139:chemically induced; D008431:Maternal-Fetal Exchange; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000196:embryology; D011247:Pregnancy
D001551:Benz(a)Anthracenes; D015127:9,10-Dimethyl-1,2-benzanthracene
Transplatsentarnyi blastomogenez u mysheĭ v usloviiakh vykliucheniia detoksitsiruiushcheĭ funktsii materinskogo organizma