Perinatal primate parathyroid hormone metabolism.
Near-term fetal and neonatal parathyroid gland function has been studied in the Rhesus monkey. Fetal serum ionized calcium (Ca++) levels are significantly greater than simultaneously obtained maternal levels. Fetal serum parathyroid hormone (PTH) was undetectable both in the basal state and in association with EDTA-induced fetal hypocalcemia. Induced maternal hypocalcemia was associated with increased maternal serum PTH levels and no change in fetal basal serum Ca++ or PTH levels. Only a minimal decrease in simian neonatal serum Ca++ occurred over the first 48 h of life. Normal adult levels of serum PTH were present as early as 6 h of neonatal life. Induced hypocalcemia at 12 h of age resulted in a significant increase in serum PTH levels.
D000818:Animals; D000831:Animals, Newborn; D002118:Calcium / Q000097:blood; D004492:Edetic Acid / Q000494:pharmacology; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D005333:Fetus / Q000378:metabolism*; D005865:Gestational Age; D008253:Macaca mulatta; D008431:Maternal-Fetal Exchange / Q000187:drug effects; D010280:Parathyroid Glands / Q000378:metabolism*; D010281:Parathyroid Hormone / Q000097:blood / Q000378:metabolism*; D011247:Pregnancy; D011270:Pregnancy, Animal; D013268:Stimulation, Chemical
D010281:Parathyroid Hormone; D004492:Edetic Acid; D002118:Calcium