Effect of simultaneous administration of polychlorinated biphenyls and alkylbenzene sulfonic acid salt in rats.
Administration of PCB to rats resulted in an increase in lever weight, hypertrophy with foam-like changes in cytoplasm of individual liver cells, an increase in liver cholesterol levels, an increase in lever aniline hydroxylase activity and a decrease in liver Na-K-Mg-dependent APTase activity. When ABS was simultaneously administered with PCB, most of the above-mentioned abnormalities were observed to increase and were dependent on administration time and dosage. Testicular abnormalities were observed only in rats on long term co-administration of PCB and ABS.
D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000815:Aniline Hydroxylase / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001557:Benzenesulfonates / Q000494:pharmacology*; D002784:Cholesterol / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism; D007501:Iron / Q000378:metabolism; D008099:Liver / Q000201:enzymology; D008297:Male; D011078:Polychlorinated Biphenyls / Q000494:pharmacology*; D012313:RNA / Q000378:metabolism; D051381:Rats; D014280:Triglycerides / Q000378:metabolism
D001557:Benzenesulfonates; D005227:Fatty Acids; D014280:Triglycerides; D012313:RNA; D004247:DNA; D002784:Cholesterol; D011078:Polychlorinated Biphenyls; D007501:Iron; D000815:Aniline Hydroxylase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase