Effects of amitriptyline and isocarboxazid on 5-hydroxytryptophan induced head twitches in mice.
Effects of amitriptyline and isocarboxazid on brain 5-HT and 5-HIAA were examined in relation to their action on 5-HTP induced head twitches. Amitriptyline reduced 5-HTP induced head twitches but isocarboxazid increased them. Both amitriptyline and isocarboxazid caused a significant increase of brain 5-HT concentration in 5-HTP treated mice. Amitriptyline also caused a significant increase of 5-HIAA concentration, while isocarboxazid reduced 5-HIAA concentration in the brains of 5-HTP treated mice. Probenecid, which significantly increased 5-HIAA concentration without affecting brain 5-HT concentration in 5-HTP treated mice, reduced 5-HTP induced heat twitches. These results suggest that 5-HTP induced head twitches might be induced by an increase of 5-HT concentration, and reduced by an increase of 5-HIAA or a decrease of 5-HT concentration in the brains of mice.
D006916:5-Hydroxytryptophan / Q000494:pharmacology*; D000639:Amitriptyline / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001923:Brain Chemistry / Q000187:drug effects; D004347:Drug Interactions; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000032:analysis; D007520:Isocarboxazid / Q000494:pharmacology*; D008297:Male; D051379:Mice; D011339:Probenecid / Q000494:pharmacology; D012701:Serotonin / Q000032:analysis; D013239:Stereotyped Behavior / Q000187:drug effects
D000639:Amitriptyline; D012701:Serotonin; D007520:Isocarboxazid; D006897:Hydroxyindoleacetic Acid; D006916:5-Hydroxytryptophan; D011339:Probenecid