Studies on stimulation and properties of antiglobulin antibodies. I. Influence of heatig at 56 degrees C and 60 degrees C on antigenicity.
The autoimmunogenic properties of whole rabbit serum heated at 56 degrees C and 60 degrees C were studied in rabbits. Autologous rabbit serum heated 20 min at 60 degrees C was immunogenic. The state of induced immunity manifested itself by the appearance of antibodies to antigens of heterologous sera: human, goat and guinea pig. No antibodies for autologous sera were found, including autologous sera heated 20 min at 60 degrees C. The antibodies for heterologous sera directed against gamma-globulins were detected by the passive hemagglutination test and by precipitation in agar gel.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis*; D000917:Antibody Formation; D000941:Antigens; D001323:Autoantibodies; D003429:Cross Reactions; D005260:Female; D006041:Goats / Q000276:immunology; D006168:Guinea Pigs / Q000276:immunology; D006386:Hemagglutination Tests; D007106:Immune Sera; D005779:Immunodiffusion; D007122:Immunoelectrophoresis; D008297:Male; D011817:Rabbits; D013045:Species Specificity; D013696:Temperature; D013997:Time Factors
D000888:Antibodies, Anti-Idiotypic; D000941:Antigens; D001323:Autoantibodies; D007106:Immune Sera