Inhibitory effect in vitro of sodium polyanethol sulfonate on the growth of Neisseria meningitidis.
The influence of 0.05% sodium polyanethol sulfonate on the growth of 24 strains of Neisseria meningitidis in broth medium was examined; several of the strains were markedly inhibited. A paper disk method was evolved for screening the sensitivity of various bacteria to sodium polyanethol sulfonate on solid medium; the highest sensitivity was observed in N. meningitidis and Neisseria gonorrhoeae. Zones of growth inhibition were also observed in a proportion of strains in certain species of gram-positive cocci, whereas all gram-negative bacilli were uniformly resistant. The implications of these observations for the routine use of sodium polyanethol sulfonate in blood culture media are discussed.
D000925:Anticoagulants / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects / Q000254:growth & development; D001557:Benzenesulfonates / Q000494:pharmacology*; D001769:Blood; D003470:Culture Media; D006193:Haemophilus influenzae / Q000187:drug effects / Q000254:growth & development; D008826:Microbial Sensitivity Tests / Q000379:methods; D009344:Neisseria gonorrhoeae / Q000187:drug effects / Q000254:growth & development; D009345:Neisseria meningitidis / Q000187:drug effects / Q000254:growth & development*; D011108:Polymers / Q000494:pharmacology*; D013045:Species Specificity
D000925:Anticoagulants; D001557:Benzenesulfonates; D003470:Culture Media; D011108:Polymers