[Studies on the behavior of chromium in serum and urine in polytraumatized patients as well as on the chromium concentration of various infusion solutions].
Determinations of the oligoelement chromium were carried out by flameless atomic absorption spectroscopy in serum, whole blood, and urine of patients, undergoing intensive care, as well as in a great part of the solutions used for parenteral nutrition. With rising amino acid and protein content, respectively, the chromium content of the infusion solutions increased due to contamination. Pure nonglucose-carbohydrate-electrolyte solutions contained 16.5-49.0 mug chromium/litre, amino acid-carbohydrate solutions 36.5-105.0 mug chromium/litre and human albumin solutions, depending on concentration, 86.9-394.2 mug chromium/litre. The average chromium concentration in the patients' serum was 11.3 +/- 0.26 mug/litre, which is twenty times more than the normal values determined by this method, and increased from 8.3 to 16.4 mug/litre within the first seven days. The urinary chromium concentrations were 37.7 +/- 4.1 mug/litre, being three times higher than the average serum values, but remained constant from day to day. The approximate chromium administration by parenteral infusion therapy was 160-250 mug chromium/day, the urinary chromium excretion was 111 +/- 20.5 mug/day. Consequently, great amounts of parenterally supplied chromium seem to be stored in the patients' tissues. Effects and risks for the organism caused by these unphysiological chromium concentrations are discussed.
D000063:Accidents, Traffic; D000596:Amino Acids; D002241:Carbohydrates; D002857:Chromium / Q000008:administration & dosage / Q000378:metabolism*; D004573:Electrolytes; D006801:Humans; D010288:Parenteral Nutrition; D012709:Serum Albumin
D000596:Amino Acids; D002241:Carbohydrates; D004573:Electrolytes; D012709:Serum Albumin; D002857:Chromium
Untersuchungen zum Verhalten des Chroms in Serum and Urin polytraumatisierter Patienten sowie der Chromkonzentration verschiedener Infusionsloösungen