title: Insoluble PHA- A B-cell mitogen in man?
abstract: Blood lymphocytes of normal individuals and of patients with chronic lymphocytic leukemia were evaluated for their blastogenic response to insoluble PHA. In at least preferential stimulation of normal B-lymphocytes was observed, whereas leukemic lymphocytes were almost insensitive. This result supports the hypothesis of a functionally defective B-lymphocyte population in chronic lymphocytic leukemia.
mesh_terms: D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D007104:Immune Adherence Reaction; D037102:Lectins / Q000494:pharmacology*; D007945:Leukemia, Lymphoid / Q000276:immunology*; D008213:Lymphocyte Activation; D008934:Mitogens; D013601:T-Lymphocytes / Q000276:immunology; D013997:Time Factors
chemical_list: D037102:Lectins; D008934:Mitogens