[Inhibition of lymphocytes pre-incubated with human chorionic gonadotropin of the blastic transformation of peripheral murine lymphocytes].
Thymocytes cultured in medium containing human chorionic gonadotrophin hormone (HCG) are capable of blocking the response of peripheral splenic lymphocytes to mitogens in medium containing no HCG. This effect is not due to cytotoxicity. Our results suggest that the inhibition of lymphocyte response by serum from gestating subjects could be due to the presence of large quantities of HCG. This would be, at least partially, and by a direct or indirect mechanism, responsible for foetal acceptance by the mother. The implications of these findings in cancerology are manifest.
D000818:Animals; D006063:Chorionic Gonadotropin / Q000494:pharmacology*; D003208:Concanavalin A; D004305:Dose-Response Relationship, Drug; D007166:Immunosuppressive Agents; D037102:Lectins; D008213:Lymphocyte Activation; D051379:Mice; D008815:Mice, Inbred Strains; D013154:Spleen / Q000276:immunology; D013268:Stimulation, Chemical; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*
D006063:Chorionic Gonadotropin; D007166:Immunosuppressive Agents; D037102:Lectins; D003208:Concanavalin A
Inhibition de la transformation blastique de lymphocytes périphériques murins par des lymphocytes pré-incubés avec l'hormone gonadotrophine chorionique