Perfluoroctylbromide as a diagnostic contrast medium in gastroenterography.
The efficacy and safety of perfluoroctylbromide as a diagnostic contrast medium for gastroenterography was studied in laboratory animals. It was found that perfluoroctylbromide possesses excellent coating properties and a short transit time in the gastrointestinal tract. The conscious animals tolerated 64 ml/kg without any toxic manifestations. Thorough hematologic, serologic and histologic examinations showed no evidence of any adverse effects. Perfluoroctylbromide may be especially useful in patients with advanced inflammatory lesions of the gastrointestinal tract or in those with risk of aspiration of contrast medium into the lungs during gastroenterographic examinations.
D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001466:Barium Sulfate; D001522:Behavior, Animal / Q000187:drug effects; D003287:Contrast Media / Q000494:pharmacology / Q000633:toxicity; D003402:Creatine Kinase / Q000097:blood; D004064:Digestive System / Q000000981:diagnostic imaging*; D004285:Dogs; D004906:Erythrocyte Count; D005260:Female; D006168:Guinea Pigs; D006845:Hydrocarbons, Fluorinated / Q000494:pharmacology / Q000633:toxicity; D007521:Isocitrate Dehydrogenase / Q000097:blood; D007770:L-Lactate Dehydrogenase / Q000097:blood; D007958:Leukocyte Count; D008297:Male; D011859:Radiography; D051381:Rats
D003287:Contrast Media; D006845:Hydrocarbons, Fluorinated; D001466:Barium Sulfate; D007770:L-Lactate Dehydrogenase; D007521:Isocitrate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D003402:Creatine Kinase; D000469:Alkaline Phosphatase