Aging and the alteration of enzymes: a review.
The present status of research on age-related alterations of enzymes is reviewed. Evidence which makes it clear that "altered" enzymes do, in fact, exist in old animals is presented. The alteration may result from either a sequence change or a post-synthetic modification. The "error hypothesis" would support the former mechanism; a proposal based upon increasing half-lives of proteins with age could explain the latter. Evidence supporting or contradicting these alternatives is discussed.
D000375:Aging; D000818:Animals; D002455:Cell Division; D046508:Culture Techniques; D004789:Enzyme Activation; D004798:Enzymes / Q000378:metabolism*; D005260:Female; D005472:Fluorouracil / Q000494:pharmacology; D005634:Fructose-Bisphosphate Aldolase / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D006801:Humans; D008861:Microsomes / Q000201:enzymology; D009251:NADPH-Ferrihemoprotein Reductase / Q000378:metabolism; D009348:Nematoda / Q000166:cytology / Q000201:enzymology; D007652:Oxo-Acid-Lyases / Q000378:metabolism; D014176:Protein Biosynthesis
D004798:Enzymes; D005954:Glucosephosphate Dehydrogenase; D009251:NADPH-Ferrihemoprotein Reductase; D005634:Fructose-Bisphosphate Aldolase; D007652:Oxo-Acid-Lyases; D005472:Fluorouracil