[Electronmicroscopic studies of the island of Langerhans of the rat pancreas after oral application of glibenclamide].
The morphological alterations of B-cells of pancreatic islets from rats were investigated 2, 8 and 24 h after a peroral application of glibenclamide. All cell organelles showed signs of activation, as enlargement of the rough endoplasmatic reticulum and the Golgi apparatus, increased number of mitochondriae and degranulation. These changes could be observed partly 2 h after glibenclamide, but the drastical alterations were found 24 h after application of the sulfonylurea.
D000818:Animals; D004721:Endoplasmic Reticulum / Q000187:drug effects; D005260:Female; D005905:Glyburide / Q000494:pharmacology*; D006056:Golgi Apparatus / Q000187:drug effects; D007515:Islets of Langerhans / Q000187:drug effects* / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D008928:Mitochondria / Q000187:drug effects; D009940:Organoids / Q000648:ultrastructure*; D051381:Rats
D005905:Glyburide
Elektronenoptische Untersuchungen der Langerhanssehen Inseln des Rattenpankreas nach peroraler Applikation von Glibenclamid