The chemical principles of chronotherapy as established from an in vitro model of circadian concentration rhythms.
A model reaction for investigating the effects of chemical parameters on circadian rhythms is suggested. Its main advantage is that oscillations occur on a minute scale rather than daily and so accelerate studies. Some factors were found to increase the period of amplitude of the oscillations, others decreased them. The chemical principles prevailing during such oscillations are itemized. The effects of adding poisons or drugs are also noted and a computer calculation has been used to show that desferrioxamine B treatment for serum iron removal could be 65 percent more effective if administered at the correct point in the circadian cycle.
D002940:Circadian Rhythm; D003201:Computers; D003676:Deferoxamine / Q000008:administration & dosage / Q000627:therapeutic use; D004334:Drug Administration Schedule; D004492:Edetic Acid / Q000097:blood; D000431:Ethanol / Q000097:blood; D006801:Humans; D007501:Iron / Q000097:blood; D008954:Models, Biological; D013805:Theobromine / Q000097:blood; D013997:Time Factors
D000431:Ethanol; D004492:Edetic Acid; D007501:Iron; D003676:Deferoxamine; D013805:Theobromine