Evaluation of narcotic and narcotic antagonist interactions in primates.
Multiple and single drug interactions were studied in morphine-dependent monkeys whose dependency was maintained by self-infusion. Naloxone, naltrexone, and cyclazocine precipitated abstinence syndrome which the animals generally controlled with increased morphine intake. Methadone and L-alpha-acetylmethadol (LAAM) initially reduced, then increased, the morphine intake. Multiple interactions were studied using ethanol, seconal, diazepam, amphetamine, and diphenylhydantoin.
D000818:Animals; D003496:Cyclazocine / Q000494:pharmacology; D003913:Dextroamphetamine / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology; D005260:Female; D000882:Haplorhini; D006801:Humans; D008253:Macaca mulatta; D008297:Male; D008691:Methadone / Q000494:pharmacology; D008692:Methadyl Acetate / Q000494:pharmacology; D009020:Morphine / Q000008:administration & dosage; D009021:Morphine Dependence / Q000503:physiopathology; D009270:Naloxone / Q000494:pharmacology; D009271:Naltrexone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology*; D009294:Narcotics / Q000494:pharmacology*; D010672:Phenytoin / Q000494:pharmacology; D012631:Secobarbital / Q000494:pharmacology; D012646:Self Administration
D009292:Narcotic Antagonists; D009294:Narcotics; D012631:Secobarbital; D009270:Naloxone; D000431:Ethanol; D009271:Naltrexone; D010672:Phenytoin; D009020:Morphine; D003496:Cyclazocine; D008692:Methadyl Acetate; D003975:Diazepam; D003913:Dextroamphetamine; D008691:Methadone