[Effect of addition of bases and amino acids on inosine biosynthesis by mutants of Bacillus subtilis].
The relationship between the inosine biosynthesis by the Bacillus subtilis mutants VNII-genetika-265 and VNII-genetika-21 and the concentrations of adenine, guanine, uracile and amino acids was investigated. Adenine and guanine in high concentrations inhibited the inosine biosynthesis in both mutants. The mutant Gene-21 showed an increased requirement for adenine as compared with the mutant Gene-265. In the presence of uracile the pattern of the relationship between the inosine growth and biosynthesis and adenine in the mutane Gene-265 was similar to that in the mutant Gene-21. Excessive concentrations of histidine and tyrosine inhibited the inosine biosynthesis.
D000225:Adenine / Q000494:pharmacology; D000596:Amino Acids / Q000494:pharmacology; D001412:Bacillus subtilis / Q000254:growth & development / Q000378:metabolism*; D006147:Guanine / Q000494:pharmacology; D007288:Inosine / Q000096:biosynthesis*; D009154:Mutation; D014498:Uracil / Q000494:pharmacology
D000596:Amino Acids; D014498:Uracil; D007288:Inosine; D006147:Guanine; D000225:Adenine
Vliianie dobavok osnovaniĭ i aminokislot na biosintez inozina mutantami Bacillus subtilis