[Thrombocytopathia with cyclo-oxygenase deficiency].
In four patients, platelet aggregation with arachidonate was absent but was normal with "Labile Aggregation Stimulating Substance". ADP (10muM) aggregation was always reversible; collagen aggregation was absent and those induced by thrombin and ristocetin were normal. Collagen did not induce 14C-serotonin release but there was some release with thrombin. There was no thromboxan B2 synthesis in these platelets. Two patients showed hereditary hemostasis defect and the others acquired cyclo-oxygenase deficiency.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000328:Adult; D001095:Arachidonic Acids / Q000378:metabolism; D001791:Blood Platelet Disorders / Q000201:enzymology*; D001792:Blood Platelets / Q000201:enzymology; D003094:Collagen / Q000494:pharmacology; D003594:Cytoplasmic Granules; D005260:Female; D006801:Humans; D008084:Lipoxygenase / Q000097:blood / Q000172:deficiency*; D008861:Microsomes / Q000201:enzymology; D010545:Peroxides / Q000378:metabolism; D010974:Platelet Aggregation; D011453:Prostaglandins / Q000378:metabolism; D012310:Ristocetin / Q000494:pharmacology; D013917:Thrombin / Q000494:pharmacology
D001095:Arachidonic Acids; D010545:Peroxides; D011453:Prostaglandins; D012310:Ristocetin; D000244:Adenosine Diphosphate; D003094:Collagen; D008084:Lipoxygenase; D013917:Thrombin
Thrombocytopathies avec déficit en cyclo-oxygénase