Waldenström's macroglobulinemia and neuropathy. Deposition of M-component on myelin sheaths.
Chronic idiopathic polyneuropathy of a primary demyelinating type developed in a man who had had recurrent herpes simplex 2 for 10 years. A serum IgM kappa M-component was demonstrated on the myelin of individual sural nerve fibers by direct immunofluorescence microscopy. Marrow lymphocytosis and serum M-component increased with time. Attempts to confirm antibody activity of the M-component were negative. The evidence suggests that the attachment of M-component to nerve is a physical-chemical one. Interaction of M-component and nerve appears to have led to the neuropathy as an early manifestation of Waldenström's macroglobulinemia.
D000914:Antibodies, Viral / Q000032:analysis; D001854:Bone Marrow Cells; D002452:Cell Count; D005455:Fluorescent Antibody Technique; D006561:Herpes Simplex / Q000150:complications / Q000473:pathology; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis*; D007145:Immunoglobulin kappa-Chains / Q000032:analysis*; D008214:Lymphocytes; D008297:Male; D008875:Middle Aged; D009186:Myelin Sheath / Q000276:immunology*; D009500:Neutralization Tests; D010525:Peripheral Nerves / Q000473:pathology; D008258:Waldenstrom Macroglobulinemia / Q000150:complications / Q000276:immunology* / Q000473:pathology
D000914:Antibodies, Viral; D007147:Immunoglobulin Light Chains; D007075:Immunoglobulin M; D007145:Immunoglobulin kappa-Chains