Tuberculous meningitis in children during the isoniazid era.
Fifty-nine cases of tuberculous meningitis in children seen at the Charity Hospital at New Orleans since the addition of isoniazid to the therapy in 1952 are reviewed. Fourteen of the children died during hopsitalization. At discharge 21 children had complete or nearly complete clinical recovery. Follow-up of 21 available long-term survivors revealed a significant number with neurologic and social disabilities. The endemicity of tuberculous infections in the households of the children and factors responsible for transmission of tubercle bacilli from an adult source are reported. The importance of chemoprophylaxis and public health measures in eliminating this disease are stressed.
D000293:Adolescent; D000328:Adult; D000636:Aminosalicylic Acids / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003391:Cranial Nerves / Q000473:pathology; D004569:Electroencephalography; D004584:Electronystagmography; D005500:Follow-Up Studies; D049673:History, 20th Century; D006801:Humans; D007361:Intelligence Tests; D007538:Isoniazid / Q000266:history* / Q000627:therapeutic use; D008145:Louisiana; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification; D009461:Neurologic Manifestations / Q000209:etiology; D013307:Streptomycin / Q000627:therapeutic use; D014376:Tuberculosis / Q000235:genetics / Q000517:prevention & control / Q000635:transmission; D014390:Tuberculosis, Meningeal / Q000150:complications / Q000188:drug therapy*; D014724:Vestibular Function Tests; D014722:Vestibule, Labyrinth / Q000473:pathology
D000636:Aminosalicylic Acids; D007538:Isoniazid; D013307:Streptomycin