Requirement for a bone marrow-derived component in the expression of cell-mediated antibacterial immunity.
Mice were X irradiated with 400 R and 1 week post-irradiation were found to be unable to develop antilisterial immunity after active or passive immunization with immunologically committed spleen lymphocytes from Listeria-immune donors. This consequence of irradiation disappeared spontaneously within 21 days of exposure to X rays. Mice irradiated with as much as 900 R could be passively protected by immunologically committed lymphoid cells from Listeria-immune donors 10 days after irradiation if they had been given normal bone marrow cells on the day or irradiation. It is concluded that, in addition to immunologically committed lymphocytes, a second cellular component is needed for the expression of antibacterial immunity. This second component is bone marrow derived.
D000818:Animals; D001853:Bone Marrow / Q000276:immunology*; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D005260:Female; D005856:Germ-Free Life; D007111:Immunity, Cellular; D007114:Immunization; D007116:Immunization, Passive; D008089:Listeria monocytogenes / Q000254:growth & development / Q000276:immunology*; D008099:Liver / Q000382:microbiology; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D011828:Radiation Chimera; D013154:Spleen / Q000166:cytology / Q000382:microbiology; D014184:Transplantation, Homologous