[Blood-CSF kinetics of penicillin G in neurosyphilis (author's transl)].
Measurements of the penicillin concentration in serum and cerebrospinal fluid patients with neurosyphilis showed that conventional therapy can attain effective treponemocidal levels for only a short time or not at all in the CSF and brain-tissue, the regions where the treponemas are found in this particular stage of disease. Intravenous infusions with high doses (0,5 mega unit penicillin-G/kg body weight in 24 hours) over more than one generation phase of the treponemas (35-43 hours) considerably improve the recovery. 16 patients were treated in this way and been followed over 2-3 years clinically and immunologically.
D000907:Antibodies, Bacterial / Q000097:blood / Q000134:cerebrospinal fluid; D001812:Blood-Brain Barrier; D005260:Female; D006801:Humans; D007075:Immunoglobulin M; D007700:Kinetics; D008297:Male; D009494:Neurosyphilis / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D010400:Penicillin G / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism* / Q000627:therapeutic use; D010402:Penicillin G Procaine / Q000627:therapeutic use; D011485:Protein Binding; D014210:Treponema pallidum / Q000276:immunology
D000907:Antibodies, Bacterial; D007075:Immunoglobulin M; D010402:Penicillin G Procaine; D010400:Penicillin G
Blut-Liquor-Kinetik von Penicillin-G bei Neurosyphilis