Binding of thiostrepton to ribosomes from thiostrepton-sensitive and -resistant Bacillus subtilis strains.
Binding of [(35)S]thiostrepton to ribosomes from thiostrepton-sensitive and -resistant strains of Bacillus subtilis was studied. Ribosomes from thiostrepton-resistant strains bound relatively little thiostrepton compared with ribosomes from thiostrepton-sensitive B. subtilis. In addition, ribosomes from revertant strains that were obtained as thiostrepton-sensitive revertants from thiostrepton-resistant strains bound [(35)S]thiostrepton similarly to ribosomes from the sensitive parental strain.
D000900:Anti-Bacterial Agents / Q000378:metabolism*; D001412:Bacillus subtilis / Q000648:ultrastructure*; D004352:Drug Resistance, Microbial; D009154:Mutation; D012270:Ribosomes / Q000187:drug effects / Q000378:metabolism*; D013462:Sulfur Radioisotopes; D013883:Thiostrepton / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D013462:Sulfur Radioisotopes; D013883:Thiostrepton