Study of a kindred with thyroxine-binding globulin deficiency and oligomenorrhea.
The finding of a low total thyroxine level in an oligomenorrheic woman uncovered a new family with thyroxine-binding globulin deficiency and oligomenorrhea. Thirteen of 17 family members had the deficiency of thyroxine-binding globulin, with heterozygous female subjects showing overlap of levels with normal subjects. Oligomenorrhea was frequently found but segregated separately from the thyroxine-binding globulin deficiency; of seven women with low levels, three had normal monthly menstrual cycles. Fertility was not impaired.
D000293:Adolescent; D000328:Adult; D005260:Female; D005298:Fertility; D006579:Heterozygote; D006801:Humans; D006980:Hyperthyroidism / Q000601:surgery; D008297:Male; D008599:Menstruation Disturbances / Q000235:genetics*; D009839:Oligomenorrhea / Q000150:complications / Q000453:epidemiology / Q000235:genetics*; D010375:Pedigree; D013965:Thyroidectomy; D013975:Thyroxine-Binding Proteins / Q000172:deficiency*
D013975:Thyroxine-Binding Proteins