title: Regulation of antibody response in different immunoglobulin classes. I. Selective suppression of anti-DNP IgE antibody response by preadministration of DNP-coupled mycobacterium.
abstract: Selective suppression of IgE antibody response was demonstrated. Preadministration of DNP-coupled mycobacterium (DNP-Tbc) inhibited the formation of anti-DNP IgE antibody induced by DNP-OA without any suppressive effect on anti-DNP IgG antibody response. Secondary anti-DNP IgE antibody response by DNP-OA was also significantly depressed by the preadministration of DNP-Tbc. Anti-OA IgE antibody response induced by DNP-OA was also depressed by DNP-Tbc, whereas anti-OA IgE antibody response induced by PAB-OA was not affected by the preadministration of DNP-Tbc. Preimmunization with DNP-MGG induced much higher anti-DNP IgG antibody response than DNP-Tbc, but DNP-MGG did not suppress the induction of anti-DNP IgE antibody. The transfer of DNP-Tbc-primed spleen cells into normal mice depressed anti-DNP IgE antibody response. B cell-depleted cell populations also showed a comparable inhibitory effect to that of unfractionated DNP-Tbc primed cells. In the adoptive cell transfer experiment, DNP-Tbc-primed cells depressed anti-DNP IgE antibody response of DNP-OA-primed cells when these cells were stimulated with DNP-OA. These results suggested that DNP-specific T cells induced with DNP-Tbc selectively inhibited IgE antibody response.
mesh_terms: D000818:Animals; D000917:Antibody Formation; D000942:Antigens, Bacterial; D001554:Benzene / Q000276:immunology*; D007114:Immunization; D007116:Immunization, Passive; D007073:Immunoglobulin E; D007074:Immunoglobulin G; D007165:Immunosuppression Therapy; D008213:Lymphocyte Activation; D008212:Lymphocyte Depletion; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009169:Mycobacterium tuberculosis / Q000276:immunology; D010047:Ovalbumin; D013154:Spleen / Q000166:cytology
chemical_list: D000942:Antigens, Bacterial; D007074:Immunoglobulin G; D007073:Immunoglobulin E; D010047:Ovalbumin; D001554:Benzene