title: Lack of antiscorbutic activity of ascorbate 2-sulfate in the rhesus monkey.
abstract: Oral administration of 10 mg per kilogram of body weight of ascorbic acid (AA) completely prevented development of scurvy in juvenile rhesus monkey (Mucaca mulata) fed an AA-free liquid diet. The same dose cured scurvy when injected intramuscularly. An equimolar dose of ascorbic acid 2-sulfate (AA-2-S) did not prevent or cure scurvy. Neither AA nor AA-2-S altered serum cholesterol. AA but not AA-2-S reduced serum triglyceride. A case of scurvy in an AA-2-S treated monkey is described in detail.
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001205:Ascorbic Acid / Q000031:analogs & derivatives* / Q000097:blood / Q000627:therapeutic use; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D004355:Drug Stability; D000882:Haplorhini; D008251:Macaca / Q000378:metabolism*; D008253:Macaca mulatta / Q000378:metabolism*; D012614:Scurvy / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D013045:Species Specificity; D014280:Triglycerides / Q000097:blood
chemical_list: D014280:Triglycerides; D002784:Cholesterol; D000469:Alkaline Phosphatase; D001205:Ascorbic Acid