title: Replicative patterning and determination.
abstract: It is suggested that determination in embryonic development involves two processes: a differential regulation of gene replication order to yield a set of gene-specific replicative patterns, and the conversion of these patterns to a set of transcription potentials by a chromosomal-binding substance. The evidence from studies of Drosophila is discussed, and experimental tests are proposed.
mesh_terms: D000818:Animals; D001665:Binding Sites; D002875:Chromosomes / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D004261:DNA Replication; D004331:Drosophila melanogaster / Q000196:embryology* / Q000378:metabolism; D005796:Genes; D006657:Histones / Q000378:metabolism; D008954:Models, Biological; D014158:Transcription, Genetic
chemical_list: D006657:Histones; D004247:DNA