title: Substituted 1-[(5-nitrofurfurylidene)amino]-4-imidazolin-2-ones.
abstract: A series of 1-[(5-nitrofurfurylidene)amino]-4-imidazolin-2-ones has been prepared. A new synthesis of 4-alkyl-1-[(5-nitrofurfurylidene)amino]-4-imidazolin-2-ones involving the oxidative ring closure of 5-nitro-2-furaldehyde 2-(2-hydroxyethylalkyl)semicarbazones is described. The in vitro testing of the compounds against a variety of bacteria is reported.
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D003352:Corynebacterium / Q000187:drug effects; D004754:Enterobacter / Q000187:drug effects; D013293:Enterococcus faecalis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009581:Nitrofurans / Q000138:chemical synthesis* / Q000494:pharmacology; D011513:Proteus mirabilis / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012485:Salmonella typhi / Q000187:drug effects; D012763:Shigella flexneri / Q000187:drug effects; D013210:Staphylococcus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D007093:Imidazoles; D009581:Nitrofurans