[Intracellular glycosaminoglycans of diploid and heteroploid human cells and of hybrid cell lines issued from their fusion].
The human heteroploid cell line D98/AH-2 shows a low level of glycosaminoglycans (GAG) synthesis as compared with normal human diploid fibroblasts. Cellular hybrids were obtained by fusion of the D98/AH-2 cell line with normal fibroblasts, and fibroblasts derived from patients with mucopolysaccharidosis type II. In these hybrids the rate of GAG synthesis is intermediate between those of the parental cell lines.
D002460:Cell Line; D002478:Cells, Cultured; D005347:Fibroblasts; D006025:Glycosaminoglycans / Q000096:biosynthesis*; D006801:Humans; D006822:Hybrid Cells / Q000378:metabolism*; D009083:Mucopolysaccharidoses / Q000378:metabolism; D011123:Polyploidy; D013462:Sulfur Radioisotopes
D006025:Glycosaminoglycans; D013462:Sulfur Radioisotopes
Glycosaminoglycannes intracellulaires de cellules humaines diploïdes et hétéroploïdes et des lignées hybrides issues de leur fusion