[Treatment of 10 cases of symptomatic Paget's disease with etidronate (EHDP)].
10 patients with active symptomatic Paget's disease of bone have been treated for 6 months with disodium etidronate (EHDP) at a dose of 20 mg/kg/day. A statistically significant fall in the serum levels of alkaline phosphatase and urinary hydroxyproline was observed. However, only 2 patients experienced a significant reduction of bone pain. 6 patients were partially improved and 2 patients showed no change. Iliac crest biopsies after treatment demonstrated dimunution of the abnormal structure of the pagetic bone, but also a considerable increase in unmineralized osteoid borders. The future potentialities for treatment of Paget's disease are discussed.
D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood; D001706:Biopsy; D001842:Bone and Bones / Q000473:pathology; D012968:Etidronic Acid / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006909:Hydroxyproline / Q000652:urine; D007085:Ilium; D008297:Male; D008875:Middle Aged; D010001:Osteitis Deformans / Q000188:drug therapy*
D000469:Alkaline Phosphatase; D012968:Etidronic Acid; D006909:Hydroxyproline
Traitement de 10 cas symptomatiques de maladie de Paget par l'étidronate (EHDP) Bilan clinique, biochimique et morphologique