[Quantitative evaluation of the effect of depression of Mycobacterium tuberculosis intracellular multiplication under the influence of antibacterial preparations].
The use of the average effective dose (ED50) for estimation of the activity of antitubercle drugs against mycobacteria situated inside the cells is proposed. The dose-effect dependence for rifampicin and cycloserin was found. Expedience in the use of the regressive analysis for determination of a number of parameters characterizing qualitatively and quantitatively the effect of the antitubercle drugs on the intracellular multiplication of the bacteria was shown. The programme developed by the authors for the electronic computer "Mir-2" is recommended for this purpose.
D000995:Antitubercular Agents / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects*; D003523:Cycloserine / Q000494:pharmacology; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D007928:Lethal Dose 50; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D012044:Regression Analysis; D012293:Rifampin / Q000494:pharmacology
D000995:Antitubercular Agents; D003523:Cycloserine; D012293:Rifampin
Kolichestvennaia otsenka éffekta podavleniia vnutrikletochnogo razmnozheniia mikobakteriĭ tuberkuleza pod vliianiem antibakterial'nykh preparatov