4,4'-isopropylidine-bis(2-isopropyl)phenol, a new inhibitor for cell wall formation of Bacillus subtilis.
4,4'-Isopropylidine-bis[2-isopropyl]phenol was found to possess antimicrobial activity against gram-positive bacteria and some fungi, whereas it had no effect on gram-negative organisms. The drug has a potent inhibitory action on the synthesis of cell wall mucopeptides of Bacillus subtilis by inhibiting the enzyme d-glutamate ligase, which is responsible for the incorporation of d-glutamic acid into uridine 5'-diphosphate-muramyl-l-alanine. The drug had a weak lytic effect on protoplasts and inhibited protein synthesis, whereas no significant effect on the synthesis of deoxyribonucleic acid and ribonucleic acid was found.
D000409:Alanine / Q000378:metabolism; D001412:Bacillus subtilis / Q000166:cytology*; D001419:Bacteria / Q000187:drug effects; D002473:Cell Wall / Q000187:drug effects* / Q000201:enzymology; D005658:Fungi / Q000187:drug effects; D005971:Glutamates / Q000378:metabolism; D008025:Ligases / Q000302:isolation & purification; D010636:Phenols / Q000494:pharmacology*; D013997:Time Factors
D005971:Glutamates; D010636:Phenols; D008025:Ligases; D000409:Alanine