title: [The application of Actihaemyl in chronically inflamed and dystrophic urinary bladder (author's transl)].
abstract: The effect of automated continuous irrigation treatment with Actihaemyl on bacterial growth in the infected urinary bladder was tested using an experimental model. The result was that instillation alone of this preparation promoted growth of Escherichia coli, Proteus mirabilis, and Pseudomonas aeruginosa in the infected bladder. With simultaneous application of Framycetinsulfate or Kanamycin the growth of Pr. mirabilis and Ps. aeruginosa was totally suppressed in the "urine", and the growth of E. coli extensively low. At the same time there was a clear reduction in the bacterial count in the coagulum that served as a substitute bladder wall. Thus a urinary tract infection is a contraindication for local treatment with Actihaemyl of a tropically disturbed urinary bladder inasmuch as an effective antibiotic is not added to the instillate. With the latter combination, however, a therapeutic trial is justified in chronic, inflammatory, dystrophic bladders.
mesh_terms: D000183:Actihaemyl / Q000627:therapeutic use; D001688:Biological Products / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004926:Escherichia coli / Q000187:drug effects; D005601:Framycetin / Q000494:pharmacology; D006801:Humans; D007612:Kanamycin / Q000494:pharmacology; D008954:Models, Biological; D010101:Oxygen Consumption / Q000187:drug effects; D011513:Proteus mirabilis / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D014020:Tissue Extracts / Q000009:adverse effects / Q000627:therapeutic use*; D014456:Ulcer / Q000628:therapy; D001743:Urinary Bladder / Q000187:drug effects / Q000378:metabolism; D001745:Urinary Bladder Diseases / Q000628:therapy*
chemical_list: D001688:Biological Products; D014020:Tissue Extracts; D000183:Actihaemyl; D005601:Framycetin; D007612:Kanamycin
vernacular_title: Actihaemyl-Anwendung bei chronisch entzündeten, trophisch gestörten Harnblasen