Dynamic studies with 99mTc-HEDP in normal subjects and in patients with bone tumors.
Blood clearance, urinary excretion, and spinal uptake of 99mTc-HEDP have been measured in ten normal control subjects. Blood clearance from 15 min is biexponential. Approximately 70% of the administered activity was excreted in the urine within 6 hr of injection. Spine-to-background ratios rise sequentially with time. Net normal bone uptake rises little after 2 hr and improved visualization of the normal skeleton therafter is due to reduction of blood background activity. In 13 patients with bone tumors, direct measurement of diphosphonate uptake by the tumor-involved and corresponding normal bone showed a continued rise in diphosphonate levels in the tumor-involved bone due to increased metabolic activity.
D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000378:metabolism*; D001842:Bone and Bones / Q000378:metabolism*; D001943:Breast Neoplasms; D012968:Etidronic Acid / Q000378:metabolism* / Q000652:urine; D005260:Female; D006801:Humans; D008175:Lung Neoplasms; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009943:Organophosphorus Compounds / Q000378:metabolism*; D010386:Pelvic Neoplasms; D011471:Prostatic Neoplasms; D011877:Radionuclide Imaging; D012512:Sarcoma, Ewing; D013667:Technetium
D009943:Organophosphorus Compounds; D013667:Technetium; D012968:Etidronic Acid