[Comparative action of carbamazepine and clofibrate in diabetes insipidus. Study of 7 cases].
A study was performed on the effects of carbamazepine and of clofibrate in 7 cases of diabetes insipidus of high origin. In 4 cases the action of the two substances used in association was studied. Carbamazepine, in a dose of 0.60 g/day was effective in all cases with negativisation of free water clearance in 5 out of 7. Clofibrate, in a dose of 1.50 g/day was effective in 4 cases out of 7 with negativation of free water clearance in 2. Both medications act by provoking the secretion of anti-diuretic hormone by the hypothalamic/posterior pituitary centres and are thus only active if a minimal secretion of ADH is still possible. There is no apparent potentialisation of the two substances, which both require a minimal possibility of ADH secretion to be active. There is no diminution in the ADH secretor effect, since both products remain active for as long as they are given, making it possible to observe in 3 out of 7 cases spontaneous cure of the diabetes insipidus, allowing suppression of the treatment.
D000293:Adolescent; D000328:Adult; D002220:Carbamazepine / Q000494:pharmacology / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D002994:Clofibrate / Q000494:pharmacology / Q000627:therapeutic use*; D003919:Diabetes Insipidus / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007031:Hypothalamus / Q000187:drug effects; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D010904:Pituitary Gland, Posterior / Q000187:drug effects; D012636:Secretory Rate / Q000187:drug effects; D013268:Stimulation, Chemical; D014667:Vasopressins / Q000378:metabolism; D014882:Water-Electrolyte Balance / Q000187:drug effects
D014667:Vasopressins; D002220:Carbamazepine; D002994:Clofibrate
Action comparée de la carbamazépine et du clofibrate dans le diabète insipide. Etude de 7 cas