[Pharmacological suppression of gestation by beta-2-aminoethylisothiourea (AET) in rats].
One I.P. injection of 2-beta-aminoethylisothiourea (150 or 200 mg/kg) given to rats on day 14 and eventually also on day 18 of gestation induced a maternal death rate ranging from 0 to 50%, together with frequent (1 dose) or systematic (2 doses) foetal resorption. This type of treatment also impairs further reproductive capacity.
D000367:Age Factors; D000818:Animals; D001835:Body Weight; D005260:Female; D005313:Fetal Death / Q000139:chemically induced*; D005327:Fetal Resorption / Q000139:chemically induced*; D005333:Fetus / Q000187:drug effects; D007668:Kidney / Q000187:drug effects; D011247:Pregnancy; D011248:Pregnancy Complications / Q000139:chemically induced*; D051381:Rats; D000338:beta-Aminoethyl Isothiourea / Q000008:administration & dosage / Q000494:pharmacology*
D000338:beta-Aminoethyl Isothiourea
Suppression pharmacologique de la gestation par la 2-beta-aminoéthylisothiourée (AET) chez la Ratte