The influence of 2 br-alpha-ergocryptine (CB-154) and apomorphine on induced prolactin secretion in the crab eating monkey (Macaca fascicularis).
The influence of apomorphine and 2 Br-alpha-ergocryptine (CB-154) on drug-induced prolactin secretion was examined in an intact and an ovariectomized monkey (Macaca fascicularis). Perphenazine administered iv at one mg/kg BW induced a rapid and marked increase in serum prolactin. Apomorphine at a concentration of 4 mg/kg BW administered prior to perphenazine delayed the perphenazine-induced prolactin rise. The iv administration of CB-154 at either 200 or 2000 mu-g/kg BW completely blocked the perphenazine response. Apomorphine injected before TRH suppressed the induced prolactin increase to this releasing hormone while CB-154, even at the very high dose, only partially blocked the TRH-induced prolactin rise. Serotonin injected iv at the level of 10 mg/kg BW induced a rapid and marked increase in serum prolactin and both apomorphine and CB-154 were able to block this response.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001971:Bromocriptine / Q000494:pharmacology*; D002369:Castration; D004873:Ergolines / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008252:Macaca fascicularis; D010053:Ovary / Q000502:physiology; D010546:Perphenazine / Q000494:pharmacology; D011388:Prolactin / Q000097:blood* / Q000276:immunology; D011863:Radioimmunoassay; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology; D013997:Time Factors
D004873:Ergolines; D001971:Bromocriptine; D013973:Thyrotropin-Releasing Hormone; D011388:Prolactin; D010546:Perphenazine; D001058:Apomorphine