Lysosomal dysfunction in colonic submucosal macrophages of rhesus monkeys caused by degraded iota carrageenan.
Administration of a degraded iota carrageenan in drinking water to rhesus monkeys resulted in storage of carrageenan in colonic submucosal macrophage lysosomes that persisted even after prolonged recovery. This storage was accompanied by alterations in lysosomal function (appearance of cytoplasmic acid phosphatase, failure of HRP laden endocytic vesicles to fuse with the carrageenan laden lysosomes). Macrophage necrosis and leukocytic infiltration were also observed. Administration of a native (HMR) carrageenan caused no alterations in colonic submucosal macrophages, nor was any storage of HMR observed.
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D002351:Carrageenan / Q000378:metabolism / Q000494:pharmacology*; D003106:Colon; D005260:Female; D000882:Haplorhini; D008247:Lysosomes / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D008253:Macaca mulatta; D008264:Macrophages / Q000187:drug effects* / Q000648:ultrastructure; D008297:Male
D002351:Carrageenan; D000135:Acid Phosphatase