title: Cogwheel rigidity related to lithium maintenance.
abstract: Neurological examinations of 27 outpatients receiving lithium carbonate maintenance therapy for recurrent affective illness revealed that most of the patients receiving lithium for more than 8 months had cogwheel rigidity. The data suggest a positive correlation between the duration of lithium maintenance and the severity of cogwheeling. Intravenous administration of benztropine, an antiparkinsonian drug, did not abolish or significantly ameliorate this symptom.
mesh_terms: D000328:Adult; D000342:Affective Symptoms / Q000188:drug therapy*; D000368:Aged; D001480:Basal Ganglia Diseases / Q000139:chemically induced*; D001590:Benztropine / Q000009:adverse effects; D001714:Bipolar Disorder / Q000188:drug therapy*; D002254:Carbonates; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008094:Lithium / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D002254:Carbonates; D001590:Benztropine; D008094:Lithium