Antimetabolic extract from the brain of the hibernating ground squirrel Citellus tridecemlineatus.
Extracts of subcortical brains from hibernating ground squirrels, when injected intravenously into rats, caused a mean decrease in oxygen consumption of 35 percent and a decline in body temperature of 5 degree C. The effects lasted from 75 minutes to 30 hours. Brain extracts of nonhibernating squirrels caused no significant changes in these parameters.
D000818:Animals; D001481:Basal Metabolism / Q000187:drug effects*; D001831:Body Temperature / Q000187:drug effects; D001921:Brain / Q000502:physiology*; D001923:Brain Chemistry; D006605:Hibernation; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D012589:Sciuridae / Q000502:physiology*; D013997:Time Factors; D014020:Tissue Extracts
D014020:Tissue Extracts