[Effect of immunostimulation by Corynebacterium parvum on evolution and metastatic dissemination of Lewis's tumor in mouse C57BL/6 mice].
Treatment with Corynebacterium parvum (C. parvum) produces a significant prolongation of survival time of Lewis tumor bearing animals and reduces strikingly the incidence of pulmonary metastasis in syngeneic C57Bl/6 mice. On the other hand, treatment with Imuran, a known immunodepressive agent, reduces survival time and facilitates metastatic dissemination in the same model.
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D001379:Azathioprine / Q000494:pharmacology; D007111:Immunity, Cellular / Q000187:drug effects; D007167:Immunotherapy; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008175:Lung Neoplasms / Q000276:immunology / Q000401:mortality; D008214:Lymphocytes / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009362:Neoplasm Metastasis; D009374:Neoplasms, Experimental / Q000276:immunology*; D011425:Propionibacterium acnes / Q000276:immunology*
D000276:Adjuvants, Immunologic; D007770:L-Lactate Dehydrogenase; D001379:Azathioprine
Effet de l'immunostimulation par Corynebacterium parvum sur l'évolution et la dissémination métastatique de la tumeur de Lewis chez la souris C57Bl/6