title: Correlation of neoplasms with incidence and localization of skeletal metastases: An analysis of 1,355 diphosphonate bone scans.
abstract: A total of 1,355 patients from clinical trails with the 99mTc-labeled bone agent, Osteoscan (99mTc-Sn -EHDP), has shown a higher incidence of skeletal abnormalities than previously reported. Overall in this study, 60% of bone scans were abnormal in patients with nonosseous neoplasms. Carcinoma of breast, lung, and prostate yielded 67%, 64%, and 62% skeletal involvement, respectively. Over 50% of all the skeletal abnormalities for the neoplastic indications were detected in the thorax and vertebra while the skull, pelvis, and extremities accounted for 22%, 38%, and 34%, respectively.
mesh_terms: D001859:Bone Neoplasms / Q000175:diagnosis*; D001943:Breast Neoplasms / Q000175:diagnosis; D012968:Etidronic Acid; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis; D008297:Male; D009362:Neoplasm Metastasis / Q000175:diagnosis*; D009943:Organophosphorus Compounds; D011471:Prostatic Neoplasms / Q000175:diagnosis; D011877:Radionuclide Imaging; D013667:Technetium
chemical_list: D009943:Organophosphorus Compounds; D013667:Technetium; D012968:Etidronic Acid