Inhibition of Huggins tumors by forced restraint.
Three experiments demonstrated that chronically administered restraint inhibits the development of DMBA-induced rat mammary tumors. The effect is exhibited in a lower proportion of positive responses, increased latency of tumor development, and lower number of tumors in positive animals when restrained animals are compared with controls. Organ weights failed to show a stress response to restraint. Molar activity data from Experiment III indicated that early in the experiment activity increased among the restrained animals on release from restraint. A fourth experiment, which employed a crystal accelerometer to assess activity, produced a similar activity pattern and also provided evidence of adrenal ascorbic acid depletion as a function of restraint.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000311:Adrenal Glands / Q000033:anatomy & histology / Q000378:metabolism; D000367:Age Factors; D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism; D005260:Female; D006801:Humans; D007103:Immobilization; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control*; D009043:Motor Activity; D009929:Organ Size; D010053:Ovary / Q000032:analysis; D051381:Rats; D013315:Stress, Psychological; D013950:Thymus Gland / Q000033:anatomy & histology; D013997:Time Factors
D015127:9,10-Dimethyl-1,2-benzanthracene; D001205:Ascorbic Acid