Influence of cytotoxic drugs on platelet functions in vitro. III. Peptichemio.
The influence of Peptichemio (m-dichloroethyl-amino-l-phenyl-alanyl-peptide complex) on the following platelet functions was studied: aggregation, release of platelet factor 4, availability of platelet factor 3, acid phosphatases and reptilase clot retraction. Concentrations of the drug corresponding to that found in plasma of treated patients did not significantly influence platelet functions. Concentrations 10 times higher brought about an inhibition. It is concluded that after current dosage of Peptichemio, bleeding disorders caused by impairement of platelet functions are improbable.
D000135:Acid Phosphatase / Q000378:metabolism; D000244:Adenosine Diphosphate / Q000494:pharmacology; D012103:Batroxobin / Q000378:metabolism; D001792:Blood Platelets / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D003094:Collagen / Q000494:pharmacology; D003864:Depression, Chemical; D004837:Epinephrine / Q000494:pharmacology; D006801:Humans; D009588:Nitrogen Mustard Compounds / Q000494:pharmacology*; D010440:Peptichemio / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D010977:Platelet Factor 3 / Q000378:metabolism
D009588:Nitrogen Mustard Compounds; D010977:Platelet Factor 3; D000244:Adenosine Diphosphate; D003094:Collagen; D010440:Peptichemio; D000135:Acid Phosphatase; D012103:Batroxobin; D002118:Calcium; D004837:Epinephrine