[Intravenous self administration of insulin in the rat].
Using a chronically implanted cardiac catheter, the ability of Rats to learn and to sustain a self-injection of regular insulin was demonstrated. During 12 days or more, 10 normal rats were shown to self-inject a daily amount of insulin averaging 7.7 I.U./kg body weight. The temporal pattern of the daily insulin self-administration was related to the recorded meal pattern. Furthermore, a positive correlation was found between the periprandial amount of self-injected insulin and the meal size.
D000818:Animals; D001522:Behavior, Animal; D006328:Cardiac Catheterization; D004435:Eating; D007275:Injections, Intravenous; D007328:Insulin / Q000008:administration & dosage*; D051381:Rats
D007328:Insulin
L'auto-administration intraveineuse d'insuline chez le rat