[Effect of orthophosphate on the growth rate and biosynthesis of tetracycline by an Actinomyces aureofaciens culture].
A low initial rate of the culture growth is an obligatory condition for intensive biosynthesis of tetracycline by Act. aureofaciens in batch fermentations. The mineral phosphorus concentration is a factor limiting the growth rate. Under conditions of model experiments, the maximum specific rate of the culture growth equaled to 0.07--0.08 hours-1 was observed in the presence of at least 40 gamma/ml of phosphorus: such a rate correlated with the mycelium productivity equaled to 0.40--0.42 gamma/mg/hour. Cultures growing at a rate of 0.02--0.03 hours-1 were most productive (4.8--4.2 gamma/mg/hour). Such a rate was attained at the phosphorus concentration of 25--30 gamma/ml.
D003470:Culture Media; D004305:Dose-Response Relationship, Drug; D010710:Phosphates / Q000494:pharmacology*; D013304:Streptomyces aureofaciens / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D013752:Tetracycline / Q000096:biosynthesis*; D013997:Time Factors
D003470:Culture Media; D010710:Phosphates; D013752:Tetracycline
Vliianie ortofosfata na skorost' rosta i biosintez tetratsiklina kul'turoĭ Actinomyces aureofaciens