title: Toxicity of aerosol propellants in the respiratory and circulatory systems. IX. Summary of the most toxic: trichlorofluormethane (FC 11).
abstract: The acute inhalational toxicity of trichlorofluoromethane (FC 11) is summarized in this paper. There is a striking similarity in threshold concentrations between the mouse and the rat on one hand and the dog and the monkey on the other. The mouse and rat require lower levels of concentration, i.e. (1 to 2.5%) to influence the respiratory system but higher levels (2.5 to 5.0%) to affect the circulatory system. The respiratory systems of the monkey and the dog have about the same sensitivity as those of the other two species in that the threshold level of FC 11 is 2.5 to 5%. The circulatory systems of the monkey and the dog can be influenced by a concentration of 0.5%.
mesh_terms: D000335:Aerosol Propellants / Q000633:toxicity*; D000336:Aerosols / Q000633:toxicity*; D000403:Airway Resistance / Q000187:drug effects; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D001794:Blood Pressure / Q000187:drug effects; D001980:Bronchi / Q000187:drug effects; D001993:Bronchodilator Agents / Q000494:pharmacology; D002415:Cats; D005617:Chlorofluorocarbons, Methane / Q000633:toxicity*; D003864:Depression, Chemical; D004285:Dogs; D006168:Guinea Pigs; D000882:Haplorhini; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D006846:Hydrocarbons, Halogenated / Q000633:toxicity*; D007928:Lethal Dose 50; D008170:Lung Compliance / Q000187:drug effects; D051379:Mice; D051381:Rats; D013045:Species Specificity; D013997:Time Factors
chemical_list: D000335:Aerosol Propellants; D000336:Aerosols; D001993:Bronchodilator Agents; D005617:Chlorofluorocarbons, Methane; D006846:Hydrocarbons, Halogenated