Hemodialysis leukopenia and polymorph random mobility-a possible correlation.
In vitro studies of polymorphs exposed to cellulose and polysulfone membranes showed severe impairment in randommobility with the cellulose membrane. In vivo studies with the two membranes showed that profound leukopenia occurred only when cellulose membrane was used. It is suggested that random mobility may have importance in the regulation of peripheral polymorph levels.
D002465:Cell Movement / Q000187:drug effects; D002482:Cellulose / Q000494:pharmacology; D002633:Chemotaxis / Q000187:drug effects; D003165:Complement System Proteins; D006801:Humans; D005779:Immunodiffusion; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007688:Kidneys, Artificial; D007958:Leukocyte Count; D007970:Leukopenia / Q000209:etiology*; D008851:Micropore Filters; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology*; D010587:Phagocytosis / Q000187:drug effects; D006435:Renal Dialysis / Q000009:adverse effects*; D013242:Sterilization; D013450:Sulfones / Q000494:pharmacology; D013997:Time Factors
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D013450:Sulfones; D002482:Cellulose; D003165:Complement System Proteins