Bioconversion of ribostamycin (SF-733). II. Isolation and structure of 3-N-acetylribostamycin, a microbiologically inactive product of ribostamycin produced by Streptomyces ribosidificus.
The isolation and structure determination of 3-N-acetylribostamycin, a microbiologically inactive derivative, produced enzymatically from ribostamycin by Streptomyces ribosidificus is described. The location of the acetyl group was established by mass and NMR spectrometry of the new compound and its derivatives, and by optical rotation studies conducted on N-ethoxycarbonyl-2-deoxystreptamine. The latter compound was obtained by partial acid hydrolysis of tri-N-ethoxycarbonyl-N-acetylribostamycin.
D000123:Acetyltransferases / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000031:analogs & derivatives*; D001412:Bacillus subtilis / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D011549:Pseudomonas / Q000187:drug effects; D012271:Ribostamycin / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D013302:Streptomyces / Q000032:analysis*
D000900:Anti-Bacterial Agents; D012271:Ribostamycin; D000123:Acetyltransferases