[The effect of proteinase inhibitors in the early stage after experimental myocardial infarction (author's transl)].
Our experiments have shown that in cats in the early phase after experimental myocardial infarction, the volume of extravascular fluid increases in the lungs while the intravascular volume decreases. A hemoconcentration developed with increased hematocrit and a fall in plasma volume. The thrombocyte count fell continuously during the first 4 hours after the infarction. The CPK activity in the region of the myocardial infarct was reduced in comparison to uninfarcted tissues. Intravenous injection of 50,000 KIU/kg Trasylol within 20 minutes after the infaction caused a significant reduction of the extravascular fluid in the lungs. All the other parameters were not changed by Trasylol administration, with the possible exception of the fall in thrombocytes which seemed to be slowed after Trasylol.
D000818:Animals; D000983:Antipyrine; D007611:Aprotinin / Q000494:pharmacology / Q000627:therapeutic use*; D001772:Blood Cell Count; D001792:Blood Platelets; D002415:Cats; D003402:Creatine Kinase / Q000378:metabolism; D004195:Disease Models, Animal; D006321:Heart / Q000503:physiopathology; D006400:Hematocrit; D007457:Iodine Radioisotopes; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology; D009206:Myocardium / Q000201:enzymology; D011652:Pulmonary Circulation; D012039:Regional Blood Flow; D012711:Serum Albumin, Radio-Iodinated
D007457:Iodine Radioisotopes; D012711:Serum Albumin, Radio-Iodinated; D007611:Aprotinin; D003402:Creatine Kinase; D000983:Antipyrine
Die Wirkung von Proteinaseninhibitoren in der Frühphase nach experimentellem Myokardinfarkt