Metabolism of 6-mercaptopurine in human leukemic cells.
The PRPP concentrations, PRPP formation, and phosphorylation of 6-mercaptopurine in leukocyte suspensions and homogenates prepared from leukemic patients were studied...
D000582:Amidophosphoribosyltransferase / Q000378:metabolism; D000818:Animals; D006801:Humans; D007041:Hypoxanthine Phosphoribosyltransferase / Q000378:metabolism; D007042:Hypoxanthines / Q000096:biosynthesis; D066298:In Vitro Techniques; D007288:Inosine / Q000378:metabolism; D007291:Inosine Monophosphate / Q000096:biosynthesis; D007938:Leukemia / Q000378:metabolism*; D007939:Leukemia L1210 / Q000378:metabolism; D015470:Leukemia, Myeloid, Acute / Q000378:metabolism; D007962:Leukocytes / Q000378:metabolism; D015122:Mercaptopurine / Q000031:analogs & derivatives / Q000378:metabolism*; D010754:Phosphoribosyl Pyrophosphate / Q000378:metabolism; D011683:Purine-Nucleoside Phosphorylase / Q000378:metabolism
D007042:Hypoxanthines; D007291:Inosine Monophosphate; D007288:Inosine; D010754:Phosphoribosyl Pyrophosphate; D015122:Mercaptopurine; D011683:Purine-Nucleoside Phosphorylase; D000582:Amidophosphoribosyltransferase; D007041:Hypoxanthine Phosphoribosyltransferase