Synthesis and preliminary pharmacological studies of some 3-substituted 5-amino-1,2,4-oxadiazoles.
Treatment of 4(5)-alkyl (or aryl)-2-aminoimidazoles with isoamyl nitrite in acetic acid gave rise to the corresponding 5(4)-substituted 2-amino-4(5)-hydroxyimino-4(5)H-imidazoles which were transformed into 3-acyl (or aroyl)-5-amino-1,2,4-oxadiazoles when treated in aqueous suspension. The results of a preliminary pharmacological investigation showed an interesting depressant activity on the CNS for one of these compounds, 5-amino-3-benzoyl-1,2,4-oxadiazole (III c). The pharmacological activities are correlated with the chemical substitutions on the oxadiazole ring.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002415:Cats; D002490:Central Nervous System / Q000187:drug effects; D002707:Chlordiazepoxide / Q000494:pharmacology; D004285:Dogs; D005260:Female; D000882:Haplorhini; D008297:Male; D051379:Mice; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats
D010069:Oxadiazoles; D002707:Chlordiazepoxide