[Effect of nitroglycerine in acute myocardial infarction: I: Sublingual nitroglycerine in the treatment of left-heart failure and pulmonary oedema (author's transl)].
In 15 patients with left ventricular failure, ten with recent myocardial infarction and five with old infarct a highly significant fall in pulmonary-artery pressure occurred within 3-5 minutes of sublingual administration of nitroglycerine, 0.8 and 1.6 mg. End-diastolic pulmonary-artery pressure, as an expression of left ventricular filling pressure, fell from 25 plus or minus 8 to 17 plus or minus 8 mm Hg (P smaller than 0.001). In some patients cardiac output rose markedly, while arterial blood pressure fell only slightly (not statistically significant). In six patients with pulmonary oedema there was a decrease in dyspnoea within a few minutes. Left-ventricular filling pressure fell markedly in all cases, in one patient from 50 to 27 mm Hg. This study indicates that nitroglycerine can be effective in the treatment of left-ventricular failure of various causes.
D000208:Acute Disease; D000284:Administration, Oral; D000368:Aged; D001794:Blood Pressure; D002302:Cardiac Output; D004304:Dosage Forms; D004417:Dyspnea; D006333:Heart Failure / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000188:drug therapy; D005996:Nitroglycerin / Q000008:administration & dosage / Q000627:therapeutic use; D011651:Pulmonary Artery; D011654:Pulmonary Edema / Q000188:drug therapy / Q000209:etiology; D014059:Tongue
D004304:Dosage Forms; D005996:Nitroglycerin
Wirkung von Nitroglycerin beim akuten Myokardinfarkt. I. Nitroglycerin sublingual zur Behandlung der Linksinsuffizienz und des Lungenödems