[Ultrastructural studies on an animal model of epiphyseolysis. Cells and matrix in the proximal growth plate of the rat tibia after administration of DL-serine(3,4,5-trihydroxybenzyl)-hydrazide] (author's transl)
After administration of DL-serine-(2,3,4-trihydroxybenzyl-)hydrazide, the growth plate of rat tibia, and most of all the zone of hypertrophic cartilage, is much widened. Numerous chondrocytes become necrotic, and their columnar arrangement disappears. There is no zone vascular invasion. Spontaneous epiphyseolyses occur frequently, The ergastoplasm is damaged most; it is dilated and forms giant and/or collapsed cisternae. At a later stage it is reduced to a few vesicles. It is assumed that the chondrocytic synthesis and secretion are disturbed. The loss of cytoplasmic processes also confirms this. In the cartilage matrix there are broad collagen fibres of an axial periodicity of 650 A, which are atypical of hyaline cartilage. Possible pathogenetic mechanisms of the distrubed fibrillogenesis are discussed in conncetion with the epiphyseolysis.
D000818:Animals; D001545:Benserazide / Q000494:pharmacology*; D002356:Cartilage / Q000187:drug effects / Q000648:ultrastructure; D002455:Cell Division / Q000187:drug effects; D004721:Endoplasmic Reticulum / Q000187:drug effects; D004839:Epiphyses, Slipped / Q000139:chemically induced / Q000473:pathology*; D006834:Hydrazines / Q000494:pharmacology*; D008297:Male; D008854:Microscopy, Electron; D009999:Ossification, Heterotopic / Q000473:pathology; D051381:Rats; D013977:Tibia / Q000187:drug effects*
D006834:Hydrazines; D001545:Benserazide
Ultrastrukturelle Untersuchungen an einem Epiphyseolysemodell