title: [Immunogenic activity of vaccines against rabies].
abstract: The effectiveness of cerebrospinal avianized and tissue vaccines against rabies produced in Czechoslovakia was compared with that of some foreign vaccines. At the same time, the results obtained were compared with the international standard - vaccine obtained on request from the World Health Organization. The following methods were used for the determination of effectiveness: determination of the content of virus in vaccine in mice, effectiveness test in guinea-pigs -- Koprowski, effectiveness test and ED50 determination in mice -- our modification of Nazarov's method. The effectiveness of the Czechoslovak cerebrospinal vaccine was very good. The results were the same as in the case of the foreign vaccines (Soviet, Bulgarian) and the international standard vaccine used for comparison. The ED50 determined in these vaccines ranged from 2.49 mg to 8.0%. The avianized Czechoslovak vaccine showed higher effectiveness of foreign vaccines (Holland, Spain, Algeria). The immunogeneity index was 0.87--1.14. For the time being, tissue vaccines are produced in testing series in Czechoslovakia; nevertheless, they gave the same results as foreign vaccines (Soviet, French). The ED50 of tissue vaccines was found to range from 5.21 mg to 16.50 mg.
mesh_terms: D000462:Algeria; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D002031:Bulgaria; D003604:Czechoslovakia; D005602:France; D006168:Guinea Pigs; D007928:Lethal Dose 50; D051379:Mice; D009426:Netherlands; D011818:Rabies / Q000276:immunology*; D011819:Rabies Vaccines / Q000592:standards* / Q000633:toxicity; D013030:Spain; D014586:USSR; D014944:World Health Organization
chemical_list: D011819:Rabies Vaccines
vernacular_title: Imunogenni aktivita vakcín proti vzteklinĕ