[Demonstration of the inhibitory effect of ethacrynic acid on permeability to chlorine].
Ethacrynic acid specifically inhibits chloride permeability in Ox erythrocyte. The I50 is 7 x 10(-6) M. The inhibitory effect is instantaneous and completely reversed by washing the cells with a Ringer solution. Dihydroethacrynic acid, a derivative that lacks the ability to combine with SH groups, also inhibits chloride permeability and the characteristics of inhibition are strictly identical. It is a proof that ethacrytic acid does not act by its reactivity with thiol groups.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002417:Cattle; D002463:Cell Membrane Permeability / Q000187:drug effects*; D002712:Chlorides / Q000378:metabolism*; D003864:Depression, Chemical; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000378:metabolism; D004976:Ethacrynic Acid / Q000031:analogs & derivatives / Q000494:pharmacology*; D066298:In Vitro Techniques
D002712:Chlorides; D004976:Ethacrynic Acid
Mise en évidence d'un effet inhibiteur de l'acide éthacrynique sur la perméabilité au chlore