title: Plasma renin activity and renal sodium and water excretion following infusion of arachidonic acid in rats.
abstract: Plasma renin activity (PRA) and urinary sodium and water excretion were measured following infusion of the prostaglandin (PG) precursor arachidonic acid (C20:4) in normal hydrated rats (saline i.v.:0.5 ml/hr/100 g body weight) and in rats with moderate volume expansion (saline i.v.:1.5 ml/hr/100 g body weight). Nonhypotensive doses of C20:4(40-70 mu/min/100 g b.w.) increased PRA in both normal and volume-expanded rats (p less than 0.05, and p less than 0.025, respectively). In volume-expanded rats, C20:4 was followed by reduced lrine volume (p less than 0.01) and sodium excretion (p less than 0.001) in comparison to volume-expanded control rats, whereas in normal hydrated rats these parameters remained unchanged after C20:4. The present results indicate that the C20:4-stimulated PG-synthetase system can increase PRA independently of the extracellular fluid volume. Furthermore, these results suggest a complex interrelationship between PG-synthetase action, activation of the renal renin-angiotensin system and urinary water and sodium excretion.
mesh_terms: D000818:Animals; D001095:Arachidonic Acids / Q000494:pharmacology*; D004231:Diuresis; D007444:Inulin / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D051381:Rats; D012083:Renin / Q000097:blood*; D012964:Sodium / Q000378:metabolism*; D013997:Time Factors; D014867:Water / Q000378:metabolism*; D010130:p-Aminohippuric Acid / Q000378:metabolism
chemical_list: D001095:Arachidonic Acids; D014867:Water; D007444:Inulin; D012964:Sodium; D011451:Prostaglandin-Endoperoxide Synthases; D012083:Renin; D010130:p-Aminohippuric Acid