[Investigation of the influence of copper and cobalt ions on the carcinogenesis by diethyl-nitrosamine (DENA) in Wistar rats (author's transl)].
Simultaneous subcutaneous applications of metal salts (CuSO4X 5H2O and CoC12 X 6 H2O respectively) have no influence on the percentage of the tumor yield after long-term subcutaneous applications of diethylnitrosamine (DENA). In accordance with results in syrian golden hamsters a high percentage of tumors of the nasal cavity (predominantly esthesioneuroepitheliomas) occur after subcutaneous injection of DENA into rats, too.
D000818:Animals; D003035:Cobalt / Q000008:administration & dosage*; D003300:Copper / Q000008:administration & dosage*; D006224:Cricetinae; D004347:Drug Interactions; D007279:Injections, Subcutaneous; D008134:Long-Term Care; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D009602:Nitrosamines; D009669:Nose Neoplasms / Q000139:chemically induced; D051381:Rats
D009602:Nitrosamines; D003035:Cobalt; D003300:Copper
Untersuchungen zum Einfluss von Kupfer- und Kobaltionen auf die Karzinogenese durch Diäthylnitrosamin (DANA) bei Wistar-Ratten