title: Catalase levels in Drosophila and the lack of induction by hypolipidemic compounds. A brief note.
abstract: Catalase (EC 1.11.1.6) activity levels were found to decrease in the fruit fly, Drosophila melanogaster, from 1 to 5 days of age and to increase from 5 to 8 days of age, followed by a second decline in old age. Feeding the hypolipidemic compounds, beta-diethylaminoethyl-alpha-p-chlorophenoxyisobutyrate hydrochloride, Nafenopin and Clofenapate did not significantly alter catalase levels. Median survival time was decreased 8.3% by feeding Clofenapate and increased up to 5.5% by beta-diethylamino-ethyl-alpha-p-chlorophenoxyisobutyrate hydrochloride.
mesh_terms: D000818:Animals; D002374:Catalase / Q000378:metabolism*; D002992:Clofenapate / Q000494:pharmacology; D002994:Clofibrate / Q000031:analogs & derivatives / Q000494:pharmacology; D004331:Drosophila melanogaster / Q000201:enzymology*; D004790:Enzyme Induction / Q000187:drug effects; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008297:Male; D009255:Nafenopin / Q000494:pharmacology
chemical_list: D000960:Hypolipidemic Agents; D009255:Nafenopin; D002992:Clofenapate; D002374:Catalase; D002994:Clofibrate