[The use of Sch 1000 in inhalation treatment with intermittent positive pressure of chronic obstructive respiratory diseases (author's transl)].
The use of the atropine derivative Sch 1000 by inhalation assisted by simultaneous intermittent positive pressure respiration was investigated in two groups of patients with moderate and severe obstruction of the respiratory tract with reference to the relationships between time and dose and effect. The maximum effect on the specific resistance (42%) was obtained after 30 minutes and persisted for about 2 hours depending on the severity of the obstruction. An attenuated effect was also still detectable after 4 hours. 50 mcg Sch 1000 was found to be an adequately effective dose. No side effects were observed on the pulse and blood pressure.
D000109:Acetylcholine / Q000037:antagonists & inhibitors; D000336:Aerosols; D000402:Airway Obstruction / Q000188:drug therapy*; D001285:Atropine / Q000627:therapeutic use*; D001286:Atropine Derivatives / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D001986:Bronchial Spasm / Q000188:drug therapy*; D001993:Bronchodilator Agents / Q000627:therapeutic use*; D002908:Chronic Disease; D004305:Dose-Response Relationship, Drug; D006801:Humans; D010919:Placebos; D010993:Plethysmography, Whole Body; D011674:Pulse / Q000187:drug effects; D012121:Respiration, Artificial; D012138:Respiratory Therapy; D013997:Time Factors; D014326:Tropanes / Q000627:therapeutic use*
D000336:Aerosols; D001286:Atropine Derivatives; D001993:Bronchodilator Agents; D010919:Placebos; D014326:Tropanes; D001285:Atropine; D000109:Acetylcholine
Anwendung von Sch 1000 in der Inhalationsbehandlung mit intermittierendem Uberdruck bei chronisch obstruktiven Atemwegserkrankungen