[Cooperative binding of tolbutamide by isolated rat Islets of Langerhans].
Rat islets of Langerhans isolated with collagenase bind tolbutamide, an antidiabetic sulfonylurea. Binding shows a cooperative relationship in the range of concentrations of tolbutamide (less than 10(-4) M) which are known to elicit a dose-related stimulation of insulin secretion.
D000818:Animals; D001665:Binding Sites; D066298:In Vitro Techniques; D007515:Islets of Langerhans / Q000378:metabolism*; D007700:Kinetics; D051381:Rats; D014044:Tolbutamide / Q000378:metabolism*
D014044:Tolbutamide
Liage coopératif du tolbutamide par les ilots de Langerhans isolés de rat