title: [The mechanism is action of hydrogen peroxide on bacterial metabolism].
abstract: Hydrogen peroxide oxidizes glutathione and lipoïc, pyruvic and alpha-ketoglutaric acids in vitro. This work with Escherichia coli shows that the oxidative decarboxylation of pyruvic acid by the peroxide in vivo takes into account its toxicity.
mesh_terms: D000105:Acetyl Coenzyme A / Q000378:metabolism; D003545:Cysteine / Q000378:metabolism; D004926:Escherichia coli / Q000187:drug effects* / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D007656:Ketoglutaric Acids / Q000378:metabolism; D011773:Pyruvates / Q000378:metabolism; D008063:Thioctic Acid / Q000378:metabolism
chemical_list: D007656:Ketoglutaric Acids; D011773:Pyruvates; D000105:Acetyl Coenzyme A; D008063:Thioctic Acid; D006861:Hydrogen Peroxide; D005978:Glutathione; D003545:Cysteine
vernacular_title: Mode d'action du peroxyde d'hydrogène sur le métabolisme bactérien