title: Effect of intracisternal phentolamine on cerebral blood flow after subarachnoid injection of blood.
abstract: The hydrogen clearance method was used to measure total and focal cerebral blood flow (CBF) in the monkey before and for 5 hours after a simulated subarachnoid hemorrhage (SAH). Some monkeys also received 0.2 to 1.0 mg/kg phentolamine intracisternally 3 hours after SAH. Results show that SAH did not change cerebrovascular resistance, but as cerebral perfusion pressure decreased, CBF fell transiently. Phentolamine injected intracisternally 3 hours after SAH produced a significant fall in arterial blood pressure; cerebrovascular resistance did not change but CBF decreased significantly. These data indicate that intracisternal phentolamine cannot be considered potentially useful to treat ischemic encephalopathy after SAH.
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001804:Blood Transfusion, Autologous; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D002946:Cisterna Magna; D004353:Drug Evaluation, Preclinical; D005260:Female; D000882:Haplorhini; D007267:Injections; D007427:Intracranial Pressure / Q000187:drug effects; D002546:Ischemic Attack, Transient / Q000188:drug therapy / Q000209:etiology; D008253:Macaca mulatta; D008297:Male; D010646:Phentolamine / Q000494:pharmacology / Q000627:therapeutic use*; D013345:Subarachnoid Hemorrhage / Q000150:complications / Q000188:drug therapy*; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D010646:Phentolamine