Diazepam in the prophylaxis of lignocaine seizures.
Diazepam 0.05-0.25 mg/kg increased the dose of lignocaine required to cause seizures in Rhesus monkeys by 24-34%. Spontaneous ventilation was maintained adequately during lignocaine administration following diazepam treatment and no adverse cardiovascular effects occurred. Before the onset of lignocaine-induced seizures in non-treated animals, the animals appeared to be drowsy. However, prior to administration of diazepam masked this effect. Convulsions were controlled by smaller doses of diazepam in non-treated animals than in diazepam-treated animals. Also, the animals that were pretreated with diazepam had a greater duration of depression after seizure.
D000136:Acid-Base Equilibrium / Q000187:drug effects; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood; D003975:Diazepam / Q000008:administration & dosage / Q000494:pharmacology*; D000882:Haplorhini; D008012:Lidocaine / Q000008:administration & dosage / Q000633:toxicity*; D008253:Macaca mulatta; D010100:Oxygen / Q000097:blood; D012640:Seizures / Q000139:chemically induced* / Q000517:prevention & control
D002245:Carbon Dioxide; D008012:Lidocaine; D003975:Diazepam; D010100:Oxygen