The effect of oxine-5-sulphonic acid on the hepatic drug metabolism in the rat.
Oxine-5-sulphonic acid inhibits the metabolism of aminopyrine in the rat liver in vitro. The characteristics of this inhibition vary according to whether the oxidative N-demethylation of the substrate is determined by the formation of the metabolite 4-aminoantipyrine or by the production of formaldehyde.
D000633:Aminopyrine N-Demethylase / Q000037:antagonists & inhibitors*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006912:Hydroxyquinolines / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D015125:Oxyquinoline / Q000031:analogs & derivatives / Q000494:pharmacology*; D051381:Rats
D006912:Hydroxyquinolines; D015125:Oxyquinoline; D000633:Aminopyrine N-Demethylase