[The effect of gentamicin on rat kidney lysosomes].
The in vitro action of gentamicin on kidney lysosomes gives rise to an increase in free acid phosphatase activity compared with total activity which points to a modification in the lysosomal membrane. These effects are more marked in pregnant rats, probably due to progesterone, but reduced in vitro by chloroquine.
D000135:Acid Phosphatase / Q000378:metabolism*; D000818:Animals; D002738:Chloroquine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D005839:Gentamicins / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D066298:In Vitro Techniques; D007668:Kidney / Q000187:drug effects* / Q000648:ultrastructure; D008247:Lysosomes / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008297:Male; D011247:Pregnancy; D011374:Progesterone / Q000494:pharmacology; D051381:Rats; D012737:Sex Factors; D012995:Solubility; D013268:Stimulation, Chemical; D013997:Time Factors
D005839:Gentamicins; D011374:Progesterone; D002738:Chloroquine; D000135:Acid Phosphatase
Influence de la gentamicine sur les lysosomes de reins chez le rat