Use of glucagon in the treatment of quinidine toxicity in the heart.
The effects of glucagon on quinidine-induced cardiac toxicity were studied in open-chest anaesthetised dogs. Glucagon along increased the heart rate and contractility; and decreased the blood pressure, duration of P-R and Q-T interval, and QRS complex. Quinidine produced dose-dependent decreases in the heart rate, blood pressure, and contractility, and lengthening of the duration of P-R and Q-T interval, and QRS complex. Glucagon abolished the changes produced by quinidine within two minutes, and appears to be a drug of choice in the treatment of quinidine toxicity in the heart.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D004562:Electrocardiography; D005260:Female; D005934:Glucagon / Q000494:pharmacology / Q000627:therapeutic use*; D006331:Heart Diseases / Q000139:chemically induced / Q000188:drug therapy; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D011802:Quinidine / Q000009:adverse effects* / Q000494:pharmacology
D005934:Glucagon; D011802:Quinidine