title: Treatment of epileptic seizures with clonazepam. A reappraisal.
abstract: The therapeutic efficacy of orally administered clonazepam has been evaluated in 32 epileptic patients, with substantial improvement in 22. The drug is active in all types of seizures, particularly in myoclonus, petit mal absences, and partial complex epilepsy; it seems the drug of choice in generalized infantile organic epilepsy, although the treatment of these patients is still unsatisfactory. In some patients, the drug seemed less effective after months of therapy. Drowsiness is the main side effect.
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D001259:Ataxia / Q000139:chemically induced; D001570:Benzodiazepinones / Q000627:therapeutic use*; D002648:Child; D002998:Clonazepam / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004341:Drug Evaluation; D004569:Electroencephalography; D004827:Epilepsy / Q000188:drug therapy*; D004832:Epilepsy, Absence / Q000188:drug therapy; D004830:Epilepsy, Tonic-Clonic / Q000188:drug therapy; D005221:Fatigue / Q000139:chemically induced; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009207:Myoclonus / Q000188:drug therapy
chemical_list: D001570:Benzodiazepinones; D002998:Clonazepam