Methotrexate and radiation therapy in the treatment of advanced head and neck tumors.
Ninety-six patients with advanced squamous cell carcinoma of the head and neck were randomized to treatment with intravenous methotrexate followed by radical irradiation or radiotherapy alone. No significant differences were demonstrated in local disease control or actuarial survival rates at three and five years. Some patients with local treatment failure were surgically salvaged.
D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy*; D003237:Connecticut; D004825:Epiglottis; D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy*; D006801:Humans; D007495:Iridium; D007822:Laryngeal Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy; D008727:Methotrexate / Q000627:therapeutic use*; D009060:Mouth Floor; D010610:Pharyngeal Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy*; D011868:Radioisotopes; D011879:Radiotherapy Dosage; D011882:Radiotherapy, High-Energy; D014062:Tongue Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy*; D014067:Tonsillar Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy*
D011868:Radioisotopes; D007495:Iridium; D008727:Methotrexate