Anti-IgA antibodies in two brothers with selective serum IgA deficiency.
A selective serum IgA deficiency with anti-IgA antibodies at high titer were found in a patient who suffered severe transfusion reactions. The same abnormalities were detected in his brother, a 72-year-old-man in good general condition. Anti-IgA antibodies were found in the IgG fraction and were directed against alpha-chains. A deficiency of isoagglutinins and an absence of heteroagglutinins in the propositus' serum could be shown.
D000368:Aged; D000888:Antibodies, Anti-Idiotypic; D000910:Antibodies, Heterophile; D000918:Antibody Specificity; D004406:Dysgammaglobulinemia / Q000097:blood* / Q000235:genetics; D006386:Hemagglutination Tests; D006801:Humans; D007106:Immune Sera; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G; D007137:Immunoglobulin alpha-Chains; D007153:Immunologic Deficiency Syndromes / Q000097:blood*; D008297:Male; D065227:Transfusion Reaction
D000888:Antibodies, Anti-Idiotypic; D000910:Antibodies, Heterophile; D007106:Immune Sera; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007137:Immunoglobulin alpha-Chains