Lateral diffusion in planar lipid bilayers.
Direct measurements by fluorescence correlation spectroscopy of lateral diffusion coefficients of fluorescent lipid analogs in lipid bilaryer membranes indicate self-diffusion coefficients D greater than 10(-7) square centimeters per second for various lipid systems above their reported transition temperatures. Cholesterol in egg lecithin at mole ratio of 1 : 2 reduces D by about twofold, while retained hydrocarbon solvent can increase it by two- to threefold.
D002784:Cholesterol / Q000502:physiology; D004058:Diffusion; D005989:Glycerides; D066298:In Vitro Techniques; D008563:Membrane Lipids / Q000502:physiology*; D010713:Phosphatidylcholines / Q000502:physiology; D013050:Spectrometry, Fluorescence; D013329:Structure-Activity Relationship; D013696:Temperature
D005989:Glycerides; D008563:Membrane Lipids; D010713:Phosphatidylcholines; D002784:Cholesterol