Application of challenge methods to the evaluation of new drugs.
Exercise-induced bronchospasm (EIB), as opposed to asthma precipitated by exercise, is a valuable laboratory tool in the study of the newer pharmacologic agents being developed for asthma therapy. EIB is uniquely suited for the screening of agents with cromolyn-sodium-like activity prior to extended clinical drug studies in large patient populations. To be used meaningfully, the challenge technique must be subjected to rigorous controls, standardization, and evaluation is preselected patient populations. Because of the inherent variability of the method, careful study design and the use of double-blind statistical controls are necessary to minimize misleading placebo effects.
D000941:Antigens / Q000008:administration & dosage; D001249:Asthma / Q000503:physiopathology / Q000517:prevention & control; D001986:Bronchial Spasm / Q000139:chemically induced / Q000188:drug therapy / Q000209:etiology*; D002986:Clinical Trials as Topic; D004205:Cromolyn Sodium / Q000627:therapeutic use; D004341:Drug Evaluation; D006801:Humans; D005082:Physical Exertion
D000941:Antigens; D004205:Cromolyn Sodium