Inhibition of the tetrahydrofolate-dependent biosynthesis of ribothymidine in tRNAs of B. subtilis and M. lysodeikticus by trimethoprim.
D001412:Bacillus subtilis / Q000378:metabolism*; D001426:Bacterial Proteins / Q000096:biosynthesis; D003864:Depression, Chemical; D008837:Micrococcus / Q000378:metabolism*; D010649:Phenylalanine / Q000378:metabolism; D012329:RNA, Bacterial / Q000096:biosynthesis; D012343:RNA, Transfer / Q000096:biosynthesis*; D012263:Ribonucleosides / Q000096:biosynthesis*; D013763:Tetrahydrofolates / Q000494:pharmacology*; D013936:Thymidine / Q000031:analogs & derivatives / Q000096:biosynthesis*; D014295:Trimethoprim / Q000494:pharmacology*; D014498:Uracil / Q000096:biosynthesis; D014529:Uridine / Q000378:metabolism
D001426:Bacterial Proteins; D012329:RNA, Bacterial; D012263:Ribonucleosides; D013763:Tetrahydrofolates; D010649:Phenylalanine; D014498:Uracil; D012343:RNA, Transfer; D014295:Trimethoprim; D013936:Thymidine; D014529:Uridine