Sex chromosome meiotic drive systems in Drosophila melanogaster I. Abnormal spermatid development in males with a heterochromatin-deficient X chromosome (sc-4sc-8).
The meiotic drive chracteristics of the In(1)sc-4Lsc-8R/Y system have been examined by genetic analysis and by light and electron microscopy. sc-4sc8-/Y males show a direct correlation between nondisjunction frequency and meiotic drive. Temperature-shift experiments reveal that the temperature-sensitive period for nondisjunction is at meiosis, whereas that for meiotic drive has both meiotic and post-meiotic components. Cytological analyses in the light and electron microscopes reveal failures in spermiogenesis in the tests of sc-4sc-8 males. The extent of abnormal spermatid development increases as nondisjunction becomes more extreme.
D000818:Animals; D004331:Drosophila melanogaster / Q000502:physiology / Q000648:ultrastructure; D005260:Female; D005787:Gene Frequency; D006570:Heterochromatin; D008297:Male; D008540:Meiosis; D008854:Microscopy, Electron; D011336:Probability; D012730:Sex Chromosomes / Q000032:analysis; D013087:Spermatids; D013091:Spermatogenesis; D013094:Spermatozoa; D013696:Temperature; D013737:Testis / Q000502:physiology
D006570:Heterochromatin