Regional intralymphatic infusion (ILI) of irradiated tumor cells with evidence of distant effects.
A case of canine lymphoma with radiographically-documented involvement of the para-aortic nodes is reported. Intralymphatic infusions (ILI) of cultured irradiated autochthonous tumor cells to remote lymph node bearing areas were associated with a dramatic initial shrinkage of the para-aortic lymphadenopathies. Three ILI timing schedules were used consecutively during a course of 10 treatments, allowing a comparison of responses in the same animal. The reported case suggests that a normal lymph node can be effectively "stimulated" by the same agent approximately every 3 weeks. A possible schedule for intralymphatic infusion is proposed for further investigation.
D000818:Animals; D000951:Antigens, Neoplasm; D002478:Cells, Cultured; D004283:Dog Diseases / Q000628:therapy*; D004285:Dogs; D007167:Immunotherapy; D007272:Injections, Intralymphatic; D008223:Lymphoma / Q000000981:diagnostic imaging / Q000276:immunology / Q000532:radiotherapy / Q000628:therapy / Q000662:veterinary*; D011859:Radiography
D000951:Antigens, Neoplasm