title: [Can polyvinylpyridine-N-oxide act as an antigen? (author's transl)].
abstract: Anaphylactic tests in guinea pigs and double-diffusion tests with rabbit serum produced no evidence of antigen-like properties of polyvinylpyridine-N-oxide (PVNO). It is very unlikely therefore that the occasional clinical observations of collapse-like states, occurring when PVNO injection is resumed after a treatment-free interval are of allergic nature. These are most probably due to erythrocyte aggregation following excessively rapid injection of PVNO, producing collapse in the terminal pulmonary vasculature by a reflex action. This reaction can be avoided by slow intravenous injection or infusion.
mesh_terms: D000707:Anaphylaxis / Q000209:etiology; D000818:Animals; D000906:Antibodies / Q000032:analysis; D000917:Antibody Formation; D000941:Antigens; D005260:Female; D005620:Freund's Adjuvant; D006168:Guinea Pigs; D005779:Immunodiffusion; D011144:Polyvinylpyridine N-Oxide / Q000276:immunology*; D011145:Polyvinyls / Q000276:immunology*; D011817:Rabbits
chemical_list: D000906:Antibodies; D000941:Antigens; D011145:Polyvinyls; D005620:Freund's Adjuvant; D011144:Polyvinylpyridine N-Oxide
vernacular_title: Kann Polyvinylpyridin-N-oxid antigen wirken?