[Parathion axial teratogenesis after giving several compounds with known anti-teratogenic or antitoxic properties in vertebrate adults or embryos after exposure to organic phosphates. Study in the quail embryo (Coturnix coturnix japonica)].
Axial abnormalities, highly specific of parathion, are prevented by pyridine aldoximes P2S, 2-PAM and TMB4. Atropine, well known as an antimuscarinic agent is ineffective and so it is for tryptophan and DMSO, compounds having protective effect on some morphogenetic disturbances induced by organic phosphates. These results point out the specificity of pyridine aldoximes as alleviating agents on the characteristic axial deformities induced by parathion.
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D003370:Coturnix / Q000196:embryology; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D009333:Neck / Q000196:embryology; D010091:Oximes / Q000494:pharmacology; D010278:Parathion / Q000037:antagonists & inhibitors / Q000633:toxicity*; D011725:Pyridines / Q000494:pharmacology; D013723:Teratogens; D014364:Tryptophan / Q000494:pharmacology
D010091:Oximes; D011725:Pyridines; D013723:Teratogens; D010278:Parathion; D001285:Atropine; D014364:Tryptophan; D004121:Dimethyl Sulfoxide
Tératogenèse axiale du parathion après action de divers composés connus chez l'adulte ou l'embryon de vertébrés pour posséder un pouvoir antitoxique ou antitératogène aprés des expositions aux phosphates organiques. Etude chez l'embryon de caille (Coturnix coturnix japonica)