Citrate anticoagulation and cell washing for intraoperative autotransfusion in the baboon.
Extracorporeal citrate was used for anticoagulation during autotransfusion of baboons. A cell-washing plasmaphoresis procedure was added in one group of animals in order to remove activated clotting materials. Both groups became hypocoagulable, but the cell-washed group had less evidence of disseminated intravascular coagulation as well as lower plasma hemoglobin levels. Citrate anticoagulation plus cell washing is a potential alternative to heparinization for autotransfusion.
D000818:Animals; D000925:Anticoagulants; D001777:Blood Coagulation / Q000187:drug effects; D001804:Blood Transfusion, Autologous; D002951:Citrates / Q000627:therapeutic use*; D000882:Haplorhini; D010215:Papio; D010956:Plasmapheresis; D013514:Surgical Procedures, Operative; D013927:Thrombosis / Q000517:prevention & control
D000925:Anticoagulants; D002951:Citrates