title: The effect of d-isoproterenol on intraocular pressure of the rabbit, monkey, and man.
abstract: D-isoproterenol d-bitartrate applied topically lowers intraocular pressure (IOP) in normal albino rabbits and rabbits with alpha-chymotrypsin-induced glaucoma. This effect is independent of any effect on systemic blood pressure or pulse rate. A similar response could not be obtained in monkey or human eyes. Subconjunctival injection of d-isoproterenol d-bitartrate to monkey eyes did not alter IOP.
mesh_terms: D000287:Administration, Topical; D000818:Animals; D002918:Chymotrypsin; D005901:Glaucoma / Q000139:chemically induced / Q000188:drug therapy; D000882:Haplorhini; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D007545:Isoproterenol / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D011674:Pulse / Q000187:drug effects; D011817:Rabbits; D013610:Tachycardia / Q000209:etiology
chemical_list: D002918:Chymotrypsin; D007545:Isoproterenol