title: [Cytological study of early embryonic mortality in laboratory mice].
abstract: Early embryogenesis of laboratory mice was studied cytologically. Preimplantation embryonic mortality in mice of the strains DBA/21Y, C57BL/61Y, 101/HY and in the CBWA females crossed with the B6 males did not exceed 4--6%. Mice of the strain AKRIY served as an exception with 29.6% preimplantation embryonic mortality level. Investigation of the chemically-induced dominant lethals showed that coarse structural chromosomal damages arrested the cleavage and caused the death of the embryos before the implantation.
mesh_terms: D000818:Animals; D000830:Animals, Laboratory / Q000196:embryology*; D002869:Chromosome Aberrations; D020964:Embryo Loss / Q000473:pathology*; D047108:Embryonic Development / Q000187:drug effects; D005260:Female; D005313:Fetal Death / Q000473:pathology*; D005799:Genes, Dominant / Q000187:drug effects; D005804:Genes, Lethal / Q000187:drug effects; D005838:Genotype; D006824:Hybridization, Genetic; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008815:Mice, Inbred Strains; D011247:Pregnancy; D013852:Thiotepa / Q000494:pharmacology; D013997:Time Factors
chemical_list: D013852:Thiotepa
vernacular_title: Tsitologicheskoe issledovanie ranneĭ émbrional'noĭ smertnosti u laboratornykh mysheĭ