title: Premature chromosome condensation and chromosome despiralization in Syrian hamster cells transformed in vitro.
abstract: In vitro neoplastic transformation of Syrian hamster cells by chemical carcinogens or Simian adeno-7 virus results in cell lines that have rare cells possessing some chromosomes identical to those referred to as premature chromosome condensation or despiralization. These phenomena occurred without the addition of viruses known to promote cell fusion.
mesh_terms: D015112:4-Nitroquinoline-1-oxide; D000348:Aflatoxins; D001580:Benzopyrenes; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002875:Chromosomes / Q000648:ultrastructure*; D007621:Karyotyping; D008938:Mitosis
chemical_list: D000348:Aflatoxins; D001580:Benzopyrenes; D015112:4-Nitroquinoline-1-oxide