Transaxial tomographic imaging of canine myocardium with 11C-palmitic acid.
Radiopharmaceuticals incorporated directly into the metabolic pathways in myocardium provide a useful means for evaluating such processes. Palmitic acid, a major physiologic substrate of myocardium, has a well-understood role in myocardial metabolism. Accordingly, 11C-palmitic acid was the substrate chosen for use in conjunction with positron emission transaxial tomography to obtain images of canine myocardium. This procedure provides high-contrast images of tranverse sections of the myocardium, with good target-to-nontarget ratios (in the image), over a period of 5 to 85 minutes. Clearance half-times for blood and myocardial tissue were found to be 4.8 and 330 min, respectively. In normal myocardium, images obtained with 11C-palmitic acid were those obtained with 13NH3 and 11CO-hemoglobin. In vivo images of hearts with myocardial infarcts showed a clear delineration of infarcts and normal tissue.
D000641:Ammonia; D000818:Animals; D002248:Carbon Monoxide; D002250:Carbon Radioisotopes; D004285:Dogs; D009203:Myocardial Infarction / Q000175:diagnosis*; D009590:Nitrogen Radioisotopes; D010169:Palmitic Acids; D011877:Radionuclide Imaging; D014054:Tomography
D002250:Carbon Radioisotopes; D009590:Nitrogen Radioisotopes; D010169:Palmitic Acids; D000641:Ammonia; D002248:Carbon Monoxide