Inhibition of glucan and levan synthesis and neuraminidase activity of oral streptococci by monkey antiserums.
A demonstration that antiserums from monkeys immunized with fructosyltransferase and glucosyltransferase reduced the activities of the enzymes in producing glucans and levans was done. The nature of the inhibiting factor has not yet been identified. The local immunization of monkeys with glycosidic hydrolases produced a sufficient amount of inhibiting principle, presumably antibody, to inhibit neuraminidase one month after the first immunization and this degree of immunization, which reached degrees of 50%, remained constant throughout 11 months of immunization of these monkeys. The immunizing principle has not yet been found in saliva. A criterion for the feasibility for immunization has been met. A significant reduction in streptoccal glucosyltransferase, fructosyltransferase, and neuraminidase activity was noted after immunization with enzymes.
D000818:Animals; D005632:Fructose / Q000037:antagonists & inhibitors; D005947:Glucose / Q000031:analogs & derivatives; D005964:Glucosyltransferases / Q000276:immunology / Q000378:metabolism; D006026:Glycoside Hydrolases / Q000276:immunology; D000882:Haplorhini; D006602:Hexosyltransferases / Q000276:immunology / Q000378:metabolism; D007106:Immune Sera / Q000494:pharmacology*; D008253:Macaca mulatta / Q000276:immunology; D009055:Mouth / Q000382:microbiology*; D009439:Neuraminidase / Q000037:antagonists & inhibitors*; D011135:Polysaccharides, Bacterial / Q000037:antagonists & inhibitors*; D013291:Streptococcus / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D001426:Bacterial Proteins
D005632:Fructose; D005947:Glucose; D005964:Glucosyltransferases; D006026:Glycoside Hydrolases; D006602:Hexosyltransferases; D007106:Immune Sera; D009439:Neuraminidase; D011135:Polysaccharides, Bacterial; C021451:inulosucrase; D001426:Bacterial Proteins