Effects of metaraminol, insulin and trasylol on the responses to haemorrhage in dogs.
The effect of addition of metaraminol, insulin and trasylol to fluid replacement with glucose-saline, on the responses to haemorrhage (30% of blood volume) in dogs, was investigated. Addition of metaraminol significantly increased the blood sugar and lactate responses to haemorrhage; the lactate-pyruvate (L/P) ratio, plasma phosphate and free fatty acid (FFA) levels were also significantly increased. A delayed hypotension was observed. Responses to haemorrhage during infusion of glucos-saline + insulin showed reduced blood sugar, blood lactate, pyruvate, and L/P ratios, plasma inorganic phosphate and FFA were diminished while, mean arterial blood pressure (MABP) changes were significantly higher than the glucose-saline group. Infusion of trasylol in glucose-saline did not significantly affect the blood sugar, lactate, and pyruvate resonses and the L/P ratio. Plasma phosphate response was also like the control group. The responses of plasma FFA and of MABP in this group were significantly higher than glucose-saline group. The mechanisms of these effects and the significance of thse results are discussed.
D000818:Animals; D007611:Aprotinin / Q000627:therapeutic use*; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D004285:Dogs; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005947:Glucose / Q000627:therapeutic use; D006470:Hemorrhage / Q000097:blood* / Q000188:drug therapy; D007328:Insulin / Q000627:therapeutic use*; D007773:Lactates / Q000097:blood; D008680:Metaraminol / Q000627:therapeutic use*; D010710:Phosphates / Q000097:blood; D011773:Pyruvates / Q000097:blood; D012965:Sodium Chloride / Q000627:therapeutic use
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D007773:Lactates; D010710:Phosphates; D011773:Pyruvates; D012965:Sodium Chloride; D008680:Metaraminol; D007611:Aprotinin; D005947:Glucose