[The effect of glucose substitutes on human uric acid metabolism (author's transl)].
Fructose, sorbitol and xylitol produce a rise in serum uric acid during intravenous injection. This is most pronounced with xylitol. The amount of increase in uric acid depends on the amount given. Irreversible decomposition of preformed adenine nucleotide in the liver is considered most important as a cause. Patients in whom there is already an impairment of the energy output on the part of the liver should not be given fructose or sorbitol and certainly not xylitol intravenously.
D000227:Adenine Nucleotides / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004734:Energy Metabolism; D005632:Fructose / Q000494:pharmacology*; D006801:Humans; D007668:Kidney / Q000378:metabolism; D007773:Lactates / Q000502:physiology; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008107:Liver Diseases / Q000378:metabolism; D011685:Purine Nucleotides / Q000378:metabolism; D011687:Purines / Q000378:metabolism; D013012:Sorbitol / Q000494:pharmacology*; D014527:Uric Acid / Q000097:blood / Q000378:metabolism*; D014993:Xylitol / Q000009:adverse effects / Q000494:pharmacology*
D000227:Adenine Nucleotides; D007773:Lactates; D011685:Purine Nucleotides; D011687:Purines; D014527:Uric Acid; D005632:Fructose; D013012:Sorbitol; D000255:Adenosine Triphosphate; D014993:Xylitol
Wirkung von Glukoseaustauschstoffen auf den Harnsäurestoffwechsel des Menschen