A reversible chemical sterilization of male langurs (Presbytisentellus entellus Dufresne): a single intratesticular injection of alpha-chlorohydrin.
A reversible sterilization of male monkeys by intratesticular administration of alpha-chlorohydrin have been studied. 2 - A single injection of alpha-chlorohydrin (100 mg/testis intratesticular) caused degenerative changes in the seminiferous tubules. Extensive necrosis and exfoliation of the seminiferous elements were consistently observed even after 45 days of treatment. Tubular and Leydig cell nuclear shrinkage was noticed. The lumen of the epididymides and vas-deferens were devoid of spermatozoa. 3 - Normal spermatogenesis was restored after 100 days of alpha-chlorohydrin administration. 4 - Liver function test were performed to ascertain whether any distrubance is caused. Serum-aminotransferases, alkaline phosphatase, plasma cholesterol, haemoglobin and hematocrit levels remained within normal limits. 5 - In conclusion, a reversible male sterilization in langurs is of particular importanze with normal liver functions. It would seem plausible to translate these observations in terms of reversible fertility control in man.
D000818:Animals; D004798:Enzymes / Q000097:blood; D000882:Haplorhini; D008297:Male; D012671:Seminiferous Tubules / Q000187:drug effects; D013245:Sterilization, Reproductive; D013737:Testis / Q000187:drug effects
D004798:Enzymes