title: Methadone maintenance.
abstract: Management of heroin addiction with oral methadone continues to create controversy. Since the first Dole-Nyswander experiments were reported almost a decade ago, methadone maintenance programs have been started in every major city in North America at an estimated public cost in the hundreds of millions of tax dollars. By the end of 1972, the United States alone spending at an annual rate in excess of $250 million, and an expenditure rate in excess of one billion dollars was occurring by the end of 1973. Despite the FDA investigational New Drug status of methadone when used for this purpose, objective data have still not been generated to substantiate the worth of Narcotic Substitution Therapy. Iatrogenic consequences are on the increase, and scepticism is growing among most pharmacologists. A critical evaluation of the entire methadone maintenance approach is being advocated by many and being attempted by some. Data currently being generated at the Philadelphia General Hospital suggest that many patients may have been better managed without methadone.
mesh_terms: D000328:Adult; D008192:Deception; D005069:Evaluation Studies as Topic; D005260:Female; D005102:Health Expenditures; D006556:Heroin Dependence / Q000534:rehabilitation*; D006801:Humans; D008297:Male; D008691:Methadone / Q000009:adverse effects / Q000627:therapeutic use* / Q000652:urine; D009020:Morphine / Q000652:urine; D010349:Patient Compliance; D012106:Research; D012959:Socioeconomic Factors; D014481:United States; D014486:United States Food and Drug Administration
chemical_list: D009020:Morphine; D008691:Methadone