Effect of erythrocytes treated with enterobacterial common antigen on experimental Salmonella typhimurium infection of mice.
The immunogenicity of enterobacterial common antigen (CA)-treated horse or mouse erythrocytes was determined in Swiss white albino mice by comparing survival rates with control mice, immunized with P. aeruginosa fraction-treated RBC and challenged in parallel with 10 LD50 S. typhimurium. The administration of small amounts of CA on horse, but not mouse, RBC significantly delayed mortality; protection was only marginally less than that evoked with 12-fold larger amounts of CA in the absence of RBC. Survival in infected animals was transient; independent of immunogen or control preparation employed, all mice were dead by day 15 after challenge.
D000818:Animals; D000942:Antigens, Bacterial; D004912:Erythrocytes; D006736:Horses; D007114:Immunization; D008297:Male; D051379:Mice; D011550:Pseudomonas aeruginosa; D012481:Salmonella Infections, Animal / Q000276:immunology*; D012486:Salmonella typhimurium; D013997:Time Factors
D000942:Antigens, Bacterial