Thrombocytopenia associated with gold therapy. Observations on the mechanism of platelet destruction.
Severe thrombocytopenia developed in a patient with rheumatoid arthritis during gold therapy. Increased numbers of marrow megakaryocytes, shortened 51Cr-labeled platelet survival and platelet phagocytosis by splenic macrophages indicated that thrombocytopenia was due to excessive platelet destruction. Aurothiomalate disodium antigenicity was demonstrated by increased lymphocyte blastogenesis, and accentuation of blood and splenic leukocyte migration in the presence of the gold salt. In vitro splenic immunoglobulin G (IgG) production was markedly increased, and a significant portion of the culture-produced IgG attached specifically to homologous platelets and platelet membranes. Serum antiplatelet antibodies could not be demonstrated, nor could it be shown that gold enhanced the binding of splenic-synthesized IgG to platelets. The data indicate an immunologic mechanism for gold-associated thrombocytopenia and permit speculation as to possible ways in which unidentified antigens may be involved in the pathogenesis in idiopathic thrombocytopenic purpura.
D000941:Antigens; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D001769:Blood / Q000378:metabolism; D001789:Blood Group Antigens; D001792:Blood Platelets / Q000187:drug effects* / Q000502:physiology; D002465:Cell Movement / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D005260:Female; D006052:Gold Sodium Thiomalate / Q000009:adverse effects* / Q000378:metabolism / Q000627:therapeutic use; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000378:metabolism; D007962:Leukocytes / Q000187:drug effects / Q000502:physiology; D008213:Lymphocyte Activation; D008264:Macrophages / Q000473:pathology; D008875:Middle Aged; D013154:Spleen / Q000378:metabolism / Q000473:pathology; D013921:Thrombocytopenia / Q000139:chemically induced*; D013936:Thymidine / Q000378:metabolism
D000941:Antigens; D001789:Blood Group Antigens; D007074:Immunoglobulin G; D006052:Gold Sodium Thiomalate; D013936:Thymidine