[The prevention and treatment of post-operative and post-traumatic oedema. Chemical laboratory tests on the renal tolerance of beta-aescin (reparil) (author's transl)].
Renal tolerance of the preparation beta-aescin (Reparil) was tested in cases of oedema following fresh soft tissue crush injuries of the extremities and surgical and reconstructive operations on the hand. Forty in-patients with healthy kidneys were treated with 10 mg beta-aescin intravenously twice daily for six days after operations on the hand and after accident surgery. During this period the following tests were carried out every day and two days after cessation of treatment: urea content in urine and serum, creatinine in serum, creatinine clearance, albumin in urine, urine osmolarity and blood and urine sugar. All values obtained were within the normal range. No impairment of total renal function was observed. Taking the stated dosage instructions and contra-indications into consideration, beta-aescin can thus be administered without hesitation.
D000293:Adolescent; D000328:Adult; D003404:Creatinine / Q000097:blood; D004487:Edema / Q000517:prevention & control*; D004928:Escin / Q000627:therapeutic use / Q000633:toxicity; D005121:Extremities / Q000293:injuries*; D005260:Female; D006230:Hand Injuries / Q000601:surgery; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000503:physiopathology; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control*; D014508:Urea / Q000097:blood
D004928:Escin; D014508:Urea; D003404:Creatinine
Postoperative und posttraumatische Odemprophylaxe und-therapie. Laborchemische Untersuchungen über die Nierenverträglichkeit von beta-Aescin (Reparil)