Glucose-glucagon relationships in adult sheep.
Glucose-glucagon relationships were examined in adult sheep. Hyperglycemia was induced by infusing glucose at 120 mg/hr/kg body weight. Hypoglycemia was obtained by infusing insulin at 1.2 U/hr. In several experiments glucose at 40 mg/hr/kg was infused with insulin to obtain hyperinsulinemia without hypoglycemia to distinguish glucose-insulin effects. Glucagon concentrations decreased during hyperglycemia and increased during hypoglycemia. This study indicates that glucose-glucagon interactions may be important in regulation of glucagon secretion in sheep.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D005260:Female; D005934:Glucagon / Q000097:blood*; D007328:Insulin / Q000097:blood; D012756:Sheep / Q000097:blood*
D001786:Blood Glucose; D007328:Insulin; D005934:Glucagon