[The relationship between stomach tumor development in mice and DMBA distribution].
The character of blastomogenic action of 7,12-dimethylbenz(a)anthracene on the stomach in its parenteral administration was studied on different lines of mice. Under the same conditions DMBA distribution was investigated in the proventriculus and gastric glandular tissues. In DMBA application on mice skin oin the dosage of 0.05 mg per animal in 0.1 ml of acetone proventricular tumors developed in 34% of mice of line CC57Br, in 10% of mice of line CC57W, and in 11% of mice of line C3HA, and in 19% of white nonpedigree mice. In intraperitoneal injection of DMBA in the dose of 0.5 mg per mouse in 0.2 ml of saline solution proventricular tumors appeared in 56% of CC57Br mice (in 9 of 16) and in one of five mice of CC57W line. Whereas, in application of DMBA onto mice skin in the dose of 0.5 mg per mouse in 0.1 ml of acetone the DMBA content in the proventriculus was 13 times higher than that in gastric glandular tissues.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000032:analysis; D000818:Animals; D001551:Benz(a)Anthracenes; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced*; D007274:Injections, Intraperitoneal; D051379:Mice; D008809:Mice, Inbred C3H; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000139:chemically induced; D010212:Papilloma / Q000139:chemically induced*; D012869:Skin Absorption; D013045:Species Specificity; D013270:Stomach / Q000032:analysis; D013274:Stomach Neoplasms / Q000139:chemically induced*
D001551:Benz(a)Anthracenes; D015127:9,10-Dimethyl-1,2-benzanthracene
Zavisimost' vozniknoveniia opukholei zheludka u myshei ot raspredeleniia DMBA