title: Purpura associated with hypergammaglobulinemia, renal tubular acidosis and osteomalacia.
abstract: Two patients with hyperglobulinemia associated with purpura were studied. One had features of Sjögren's syndrome, while the other appeared to have a primary condition -- "chronic benign purpura". Both patients also had renal tubular acidosis, osteomalacia and renal calculi, with disturbed calcium metabolism and acid-base balance. Autoantibodies were detected in the serum of both patients, and mononuclear cell infiltrates were noted in skin and kidney biopsies from both.
mesh_terms: D000136:Acid-Base Equilibrium; D000141:Acidosis, Renal Tubular / Q000150:complications* / Q000175:diagnosis; D001798:Blood Proteins / Q000032:analysis; D004573:Electrolytes / Q000097:blood; D005260:Female; D006801:Humans; D007085:Ilium / Q000473:pathology; D007136:Immunoglobulins / Q000032:analysis; D007668:Kidney / Q000473:pathology; D007677:Kidney Function Tests; D008875:Middle Aged; D010018:Osteomalacia / Q000150:complications* / Q000175:diagnosis; D011694:Purpura, Hyperglobulinemic / Q000150:complications* / Q000175:diagnosis; D012859:Sjogren's Syndrome / Q000150:complications / Q000175:diagnosis; D012867:Skin / Q000473:pathology
chemical_list: D001798:Blood Proteins; D004573:Electrolytes; D007136:Immunoglobulins