[Evaluation of antibrucellic vaccines in mice].
The activity of the antibrucellic vaccines was tested on mice by vaccination at varying doses. The vaccinated mice and the controls were then challenged with a fixed quantity of virulent brucella. The animals were then sacrificed, the spleens were weighed and a count was taken of the virulent brucella which they contained. These two indications, weight of the spleen and intensity of infection, allow to compare the activity of the vaccines and to have an indispensible routine test for production control.
D000818:Animals; D002004:Brucella Vaccine / Q000592:standards*; D002003:Brucella abortus / Q000254:growth & development* / Q000276:immunology; D002006:Brucellosis / Q000382:microbiology / Q000517:prevention & control*; D009929:Organ Size; D013154:Spleen / Q000033:anatomy & histology / Q000382:microbiology; D013997:Time Factors
D002004:Brucella Vaccine
Contrôle des vaccins antibrucelliques sur souris