title: Growth inhibition of tubercle bacilli after pulsed exposures to combinations of antituberculous drugs.
abstract: All possible pairs of drugs chosen from the primary antituberculous agents including isoniazid, streptomycin, rifampin, and ethambutol were compatible and inhibited growth after administration to tubercle bacilli in a single 7 hr pulsed exposure. In general, combined drug effects could be best described as additive.
mesh_terms: D000995:Antitubercular Agents / Q000494:pharmacology*; D004338:Drug Combinations; D004977:Ethambutol / Q000494:pharmacology; D007538:Isoniazid / Q000494:pharmacology; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000254:growth & development*; D012293:Rifampin / Q000494:pharmacology; D013307:Streptomycin / Q000494:pharmacology; D013997:Time Factors
chemical_list: D000995:Antitubercular Agents; D004338:Drug Combinations; D004977:Ethambutol; D007538:Isoniazid; D012293:Rifampin; D013307:Streptomycin