A killed vaccine derived from the oncogenic Herpesvirus ateles.
A killed herpesvirus vaccine was prepared by inactivation of the oncogenic Herpesvirus ateles (HVA) with heat and formaldehyde. The vaccine proved safe in 9 marmosets (Saguinus oedipus) during a period of 461 days. The vaccinated marmosets developed high titers of serum antibodies against HVA and were resistant to 316 lethal dose 50 (LD50) cell-free HVA; the nonvaccinated control monkeys died of malignant lymphoma. The 5 challenged monkeys are clinically well and have now been under observation for 362 days.
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D002143:Callitrichinae; D005557:Formaldehyde; D006564:Herpesviridae / Q000276:immunology*; D006358:Hot Temperature; D008223:Lymphoma / Q000517:prevention & control*; D009374:Neoplasms, Experimental / Q000517:prevention & control; D014611:Vaccination; D014765:Viral Vaccines
D000914:Antibodies, Viral; D014765:Viral Vaccines; D005557:Formaldehyde