Adjuvant effect of cord factor, a mycobacterial lipid.
Cord factor was a good adjuvant in mice and rats but exerted little if any adjuvant effect in guinea pigs. In rats, cord factor not only enhanced antibody production but also induced delayed hypersensitivity. Wax D was a weak adjuvant in mice. Cord factor caused a marked inflammatory swelling at the sites of injection in mice, but it caused no such swelling in rats and guinea pigs.
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000917:Antibody Formation; D003311:Cord Factors / Q000276:immunology*; D005260:Female; D006017:Glycolipids / Q000276:immunology*; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000276:immunology; D008198:Lymph Nodes / Q000033:anatomy & histology; D009169:Mycobacterium tuberculosis; D009929:Organ Size; D051381:Rats; D013433:Sulfoglycosphingolipids / Q000494:pharmacology
D000276:Adjuvants, Immunologic; D003311:Cord Factors; D006017:Glycolipids; D013433:Sulfoglycosphingolipids