[Active and passive fibr0us septa in severe hepatic fibrosis of man: demonstration of collagen hyperfibers by electron microscopy].
In the prospective study of the evolutive progonsis of severe human hepatic fibrosis, electron microscopic examination reveals within fibrous septa a peculiar form of collagen, the hyperfiber singularized by its large diameter. The conditions of the elaboration the elaboration of this type of fiber (inflammation and intense fibrogenesis) are the classic determinant factors of an unfavorable prognosis. The stages of its elaboration are not clear and allow two possible interpretations related to the remodeling stages of collagen.
D002908:Chronic Disease; D003094:Collagen / Q000378:metabolism; D006505:Hepatitis / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008099:Liver / Q000473:pathology; D008854:Microscopy, Electron
D003094:Collagen
Les septa fibreux actifs et passifs dans les fibroses hépatiques séveères chez l'homme: mise en évidence d'hyperfibres de collagène en microscopie électronique