title: [Retardation of the excitation conduction by propaphenone. Duration and dosage effect relation after oral administration (author's transl)].
abstract: After oral administration, and depending on dosage, propaphenone produces a uniform delay of the excitation conduction in the region of the atrium, ventricle and atrioventricular conduction. At a dosage of 5 or 10 mg/kg body-weight (1 or 2x 300 mg capsules) propaphenone causes an average delay of excitation conduction of + 11% or + 19% of the initial value, and of + 39% (capsule) or + 30% (sugar coated tablet) at 14 mg/kg body-weight. The maximum effect is attained 2.5 to 4 hours after administration. A prolongation of conduction times and consequently of the anti-arrhythmic efficacy, is still found eight hours after oral ingestion.
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001145:Arrhythmias, Cardiac / Q000188:drug therapy*; D001281:Atrial Fibrillation / Q000139:chemically induced; D001283:Atrioventricular Node / Q000187:drug effects; D001682:Biological Availability; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D004562:Electrocardiography; D005260:Female; D006325:Heart Atria / Q000187:drug effects; D006327:Heart Block / Q000139:chemically induced; D006329:Heart Conduction System / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D006352:Heart Ventricles / Q000187:drug effects; D006801:Humans; D008297:Male; D011412:Propanolamines / Q000009:adverse effects; D011427:Propiophenones / Q000008:administration & dosage* / Q000009:adverse effects; D013614:Tachycardia, Paroxysmal / Q000503:physiopathology
chemical_list: D011412:Propanolamines; D011427:Propiophenones
vernacular_title: Hemmung der Erregungsleitung durch Propafenon. Dauer und Dosiswirkungsbeziehung nach oraler Anwendung