Granulocyte transfusions in children using filter-collected cells.
Twenty-three children with various stages and morphologic types of leukemia were treated with multiple granulocyte transfusions obtained by filtration leukapheresis when neutropenia-associated infection appeared unresponsive to antibiotics. All children meeting the above qualifications were given granulocyte transfusions during this time period. Twenty-one of 23 became afebrile during or shortly after the transfusions; one died with disseminated Herpes simplex; and one became well enough to be discharged, although he was never free of fever. Frequent mild to moderate fever and chills were noted. One child developed a severe pulmonary reaction followed by resolution of pneumonia. Filtration leukapheresis is a useful adjunct in controlling severe infections in neutropenic children.
D000293:Adolescent; D000380:Agranulocytosis / Q000628:therapy*; D001803:Blood Transfusion; D002469:Cell Separation / Q000379:methods; D002648:Child; D002675:Child, Preschool; D005260:Female; D005374:Filtration; D006098:Granulocytes; D006801:Humans; D017053:Infection Control; D007938:Leukemia / Q000150:complications / Q000628:therapy*; D007962:Leukocytes; D008297:Male; D009503:Neutropenia / Q000209:etiology / Q000628:therapy*; D009757:Nylons
D009757:Nylons