title: Comparison of the germicidal activity of prepodyne and betadine surgical scrub solutions.
abstract: Two iodophoric surgical scrubs soaps, Prepodyne and Betadine, were evaluated for bacteriocidal activity in a modified phenol coefficient test. A standard inoculum of each of 18 species of microorganisms was mixed with a 1:8 dilution of each iodophor and subcultured after one, three, and five minutes of exposure. Complete cidal activty was exhibited by both Prepodyne and Betadine. Twenty-five subjects were tested in hand washing experiments using Betadine and Prepodyne surgical scrub solutions. Quantitative fingerprint cultures were obtained before and after hand washing. Betadine resulted in an 85.2 per cent plus or minus 24 per cent decrease; Prepodyne, and 83.6 per cent plus or minus 21 per cent decrease. It can'be concluded from this data that there is no difference in bacteriocidal effectiveness between the two scrub soaps.
mesh_terms: D000150:Acinetobacter / Q000187:drug effects; D001419:Bacteria / Q000187:drug effects*; D002175:Candida / Q000187:drug effects; D002478:Cells, Cultured; D004202:Disinfectants / Q000494:pharmacology*; D004755:Enterobacteriaceae / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D006225:Hand / Q000382:microbiology*; D006801:Humans; D007455:Iodine / Q000494:pharmacology*; D007466:Iodophors / Q000494:pharmacology*; D007711:Klebsiella pneumoniae / Q000187:drug effects; D011205:Povidone / Q000031:analogs & derivatives*; D011206:Povidone-Iodine / Q000494:pharmacology; D011511:Proteus / Q000187:drug effects; D011513:Proteus mirabilis / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012475:Salmonella / Q000187:drug effects; D012706:Serratia marcescens / Q000187:drug effects; D012764:Shigella sonnei / Q000187:drug effects; D012915:Soaps / Q000494:pharmacology*; D013210:Staphylococcus / Q000187:drug effects; D013291:Streptococcus / Q000187:drug effects; D013297:Streptococcus pyogenes / Q000187:drug effects; D013514:Surgical Procedures, Operative
chemical_list: D004202:Disinfectants; D007466:Iodophors; D012915:Soaps; D011206:Povidone-Iodine; D007455:Iodine; D011205:Povidone