Various bilirubin conjugates in pregnant and nonpregnant rats with and without phenobarbital treatment.
The relative participation of bilirubin conjugating systems other than uridine diphosphate glucuronic acid-dependent bilirubin glucuronyl transferase in 21-day pregnant (P) and nonpregnant (NP) rats with and without prior phenobarbital (PB) administration was studied. Relative enzyme activities of 74.5%, 17.6%, and 7.9% were observed for glucuronic acid, xylose, and glucose conjugates, respectively, in untreated NP rats. Pregnancy itself did not alter the relative activities. In response to PB administration, P rats increased activity less than NP animals for all three enzymes. The ratios of the three conjugates remained unchanged in both P and NP groups after PB stimulation.
D000818:Animals; D001663:Bilirubin / Q000378:metabolism*; D005260:Female; D005947:Glucose / Q000378:metabolism; D005964:Glucosyltransferases / Q000378:metabolism; D005965:Glucuronates / Q000378:metabolism; D014453:Glucuronosyltransferase / Q000378:metabolism; D010430:Pentosyltransferases / Q000378:metabolism; D010634:Phenobarbital / Q000494:pharmacology*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D051381:Rats; D014540:Uridine Diphosphate Xylose; D014994:Xylose / Q000378:metabolism
D005965:Glucuronates; D014540:Uridine Diphosphate Xylose; D014994:Xylose; D005964:Glucosyltransferases; D014453:Glucuronosyltransferase; D010430:Pentosyltransferases; D005947:Glucose; D001663:Bilirubin; D010634:Phenobarbital