[Anesthesia using piritramide and chlorpromazine in dogs].
Piritramide with chlorpromazine in doses of 3 mg kg-1 of live weight causes total anesthesia the intensity of which differs according to the breed and condition of the individual. Anesthesia sets in in 30 to 45 minutes and lasts for 3/4 to 1 1/2 hour. During the anesthesia somatic temperature and frequency of pulse decrease, and even after 24 hours they do not reach the original values. In a majority of cases breathing frequency rises insignificantly, and after 2 to 3 hours it returns to the normal. In single cases there occurs an extreme increase of the number of respirations. The per minute breath volume in the various cases and measurings differs considerably. In the course of anesthesia there occurs an increase of glucose, a decrease of the total protein, an increase of the activity of GPT and GOT, a decrease of the numbers of erythrocytes, of haematocrit and haemoglobin, an increase of pCO2 of the blood, and a decrease of the actual pH of the blood. In the number of leucocytes no changes occurred. The changes in the BE were insignificant. All deviations, except the deviations of the pulse and of the temperature, return to the original values within 24 hours. In the ECG there occurred a fluctuation in the forming of emotions and changes of the amplitude values of the QRS group and of the T wave. In the EEG striking periodical complexes of slow waves were found or combinations of slow and rapid frequencies.
D000136:Acid-Base Equilibrium / Q000187:drug effects; D000768:Anesthesia, General; D000777:Anesthetics; D000818:Animals; D001786:Blood Glucose; D002746:Chlorpromazine; D004285:Dogs; D004357:Drug Synergism; D007540:Isonipecotic Acids; D009570:Nitriles; D010880:Piperidines; D011674:Pulse / Q000187:drug effects; D012119:Respiration / Q000187:drug effects; D000637:Transaminases / Q000097:blood
D000777:Anesthetics; D001786:Blood Glucose; D007540:Isonipecotic Acids; D009570:Nitriles; D010880:Piperidines; D000637:Transaminases; D002746:Chlorpromazine
Znecitlivĕní piritramidem) s chlorpromazinem) u psü