[Value of sequential scintrigraphy and clearance determination following normo- and hypothermic renal ischemia].
Using quantitative sequential camera scintigraphy and simultaneous separated clearance determinations with 131-I-Hippuran and 169-Yb-EDTA renal function was measured applying a new surgical method which permits in-situ kidney perfusion and cooling in animals and patients. While mongrel dogs of 15 kg average weight (control group of N = 5) showed after 1 hour of normothermic ischaemia a postoperative delay of intrarenal transport of 131-I-Hippuran with reduction of 131-I-Hippuran and 169Yb-EDTA clearances, renal function returned to normal on the first postoperative day after 1-hour (N = 5) and 2-hour (N = 5) hypothermic ischaemia. In patients (N = 9) with hypothermic in-situ perfusion of between 40 and 92 min duration a transient postoperative delay of intrarenal 131-I-Hippuran transport and a reduction of the 131I-Hippuran clearance was observed which returned to almost normal 1 1/2 to 3 months after surgery. The results and the significance of the method discussed and are compared with clinical findings and with radiological and laboratory renal function studies.
D000818:Animals; D004285:Dogs; D004492:Edetic Acid; D005260:Female; D006801:Humans; D007035:Hypothermia / Q000503:physiopathology*; D007036:Hypothermia, Induced; D007465:Iodohippuric Acid; D007511:Ischemia / Q000503:physiopathology*; D007668:Kidney / Q000098:blood supply*; D007669:Kidney Calculi / Q000601:surgery; D008657:Metabolic Clearance Rate; D010477:Perfusion; D011182:Postoperative Care; D011300:Preoperative Care; D011866:Radioisotope Renography; D011868:Radioisotopes; D011877:Radionuclide Imaging; D012039:Regional Blood Flow; D013997:Time Factors; D014567:Urography; D015018:Ytterbium
D011868:Radioisotopes; D007465:Iodohippuric Acid; D004492:Edetic Acid; D015018:Ytterbium
Aussagewert von Funktionsszintigraphie und Clearance-Bestimmung nach normo- und hypothermer Ischämie der Niere