title: [The mutagenic effect of thioTEPA in laboratory mice. IV. The influence of genotype and sex on the frequency of induced chromosome aberrations in bone marrow cells].
abstract: In bone marrow cells of eleven genotypes of mice strain and sex variations in sensitivity to cytogenetic effect of thio-TEPA were studied. Strains 101/H, C57BL/6 and A/Sn were the more sensitive and F1 (CBAXC57BL/6) and F1 (C3HX101) were the more resistant to induction of chromosome damages. The rate of induced chromosome aberrations was correlated with the level of spontaneous chromosome damages in bone marrow cells (r=+/-0,893+/-0,02). From all strains males were more mutable than females. It is recommended to use C57BL/6 strain of mice male for genetic tests of chemicals by cytogenetic methods in vivo.
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells; D002869:Chromosome Aberrations; D005260:Female; D005838:Genotype; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008808:Mice, Inbred CBA; D009153:Mutagens; D012737:Sex Factors; D013852:Thiotepa / Q000633:toxicity*
chemical_list: D009153:Mutagens; D013852:Thiotepa
vernacular_title: Mutagennyĭ éffekt tioTEF u laboratornykh mysheĭ. Soobshchenia IV. Vliianie  genotipa i pola na chastotu indutsirovannykh khromosomnykh aberratsiĭ v kletkakh kostnogo mozga