[Some patterns in the distribution of free and bound monomycin in the organs and tissues of immunized animals].
Distribution of unbound and bound monomycin in rabbits immunized against paratyphoid fever and colibacteriosis was studied at various stages of the immunization. The studies showed that the immunological reconstruction had a definite effect on the distribution character and the processes of the antibiotic binding in the vaccinized rabbits. The binding processes in the lymphoid cells increased, while those in the parenchimatose cells decreased. The concentration of the unbound and bound preparation in the organs and tissues at the background of the immunity was 2-3 times lower than that in the non-immunized animals. The bone marrow, where it markedly increased was an exception.
D000372:Agglutination Tests; D000818:Animals; D001428:Bacterial Vaccines / Q000008:administration & dosage; D001666:Binding Sites, Antibody; D015643:Erythromycin Ethylsuccinate / Q000032:analysis / Q000276:immunology / Q000494:pharmacology*; D004927:Escherichia coli Infections / Q000276:immunology; D005609:Free Radicals; D007109:Immunity / Q000187:drug effects*; D007114:Immunization; D005779:Immunodiffusion; D007273:Injections, Intramuscular; D011817:Rabbits; D013997:Time Factors; D014436:Typhoid-Paratyphoid Vaccines / Q000008:administration & dosage
D001428:Bacterial Vaccines; D005609:Free Radicals; D014436:Typhoid-Paratyphoid Vaccines; D015643:Erythromycin Ethylsuccinate
Nekotorye zakonomernosti raspredeleniia svobodnogo i sviazannogo monomitsina v organakh i tkaniakh immunizirovannykh zhivotnykh