title: Modified polyriboinosinic-polyribocytidylic acid, an immunological adjuvant.
abstract: Stabilization of polyriboinosinic-polyribocytidylic acid against enzymatic hydrolysis by addition of poly-1-lysine and carboxymethylcellulose (PICLC) resulted in a compound with marked adjuvanticity. The primary antibody response of rhesus monkeys to formalin-inactivated Venezuelan equine encephalomyelitis virus vaccine was significantly potentiated if the vaccine was combined with PICLC prior to vaccination. The antibody response was maintained at a significantly higher level than controls for 2.5 months postvaccination and paralleled immunological responses reported for live, attenuated (TC-83) vaccine.
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D000917:Antibody Formation; D002266:Carboxymethylcellulose Sodium; D004666:Encephalitis Virus, Venezuelan Equine / Q000276:immunology*; D005557:Formaldehyde / Q000494:pharmacology; D000882:Haplorhini; D008239:Lysine; D008253:Macaca mulatta; D011070:Poly I-C; D014613:Vaccines, Attenuated; D014765:Viral Vaccines
chemical_list: D000276:Adjuvants, Immunologic; D014613:Vaccines, Attenuated; D014765:Viral Vaccines; D005557:Formaldehyde; D008239:Lysine; D002266:Carboxymethylcellulose Sodium; D011070:Poly I-C