Stimulator T cells: involvement in the induction of cell-mediated cytotoxicity.
Spleen cells of mice primed by injection of normal or formaldehyde-treated allogeneic or xenogeneic tumor cells show a dramatically enhanced capacity to generate cytotoxic cells in vitro. This effect appears to be due to priming of a relatively anti-Thy-1 resistant T cell, which does not display immunologic specificity.
D000042:Absorption; D000818:Animals; D002460:Cell Line; D002478:Cells, Cultured; D002860:Chromium Radioisotopes; D003165:Complement System Proteins; D003601:Cytotoxicity Tests, Immunologic; D007106:Immune Sera; D007111:Immunity, Cellular; D008214:Lymphocytes / Q000528:radiation effects; D012515:Mast-Cell Sarcoma / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009101:Multiple Myeloma / Q000276:immunology; D011830:Radiation Effects; D051381:Rats; D011916:Rats, Inbred F344; D013601:T-Lymphocytes / Q000276:immunology*
D002860:Chromium Radioisotopes; D007106:Immune Sera; D003165:Complement System Proteins