Synthesis and antimicrobial activity of certain imidazo[1,2-a]pyrimidines.
A series of 5-substituted and 5,7-disubstituted imidazo[1,2-a]pyrimidines has been prepared. The in vitro antimicrobial activity of these compounds against a variety of microorganisms is reported. 5-n-Octylaminoimidazo[1,2-a]pyrimidine exhibited significant activity against all the microorganisms studied.
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D004821:Epidermophyton / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D007093:Imidazoles / Q000138:chemical synthesis / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008864:Microsporum / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D013056:Spectrophotometry, Ultraviolet; D013211:Staphylococcus aureus / Q000187:drug effects; D014249:Trichophyton / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D007093:Imidazoles; D011743:Pyrimidines