[Similarities in the biochemical effects of tetrachloro 2,3,7,8 dibenzo-p-dioxin and tetrabromo-2,3,7,8 dibenzo-p-dioxin on rats].
Screening tests for the study of carcinogenic compounds showed that 2,3,7,8-tetrabromodibenzo-p-dioxin was at least as active as 2,3,7,8-tetrachlorodibenzo-p-dioxin in regard to its effect on the in vivo synthesis of zoxanzolamine hydroxylase and on the arginase activity of the liver. The biological properties of these compounds seem to be due to the symmetry of their m molecular structure.
D000818:Animals; D001119:Arginase / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D003864:Depression, Chemical; D004147:Dioxins / Q000494:pharmacology*; D004790:Enzyme Induction; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D006899:Mixed Function Oxygenases / Q000096:biosynthesis; D000072317:Polychlorinated Dibenzodioxins / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship; D015049:Zoxazolamine
D004147:Dioxins; D000072317:Polychlorinated Dibenzodioxins; D015049:Zoxazolamine; D006899:Mixed Function Oxygenases; D001119:Arginase
Similitudes des effects biochimiques, chez le Pat, de la tétrachloro-2,3,7,8 dibenzo-p-dioxin et de la tétrabromo-2,3,7,8 dibenzo-p-dioxin