title: 3' non-coding region sequences in eukaryotic messenger RNA.
abstract: The sequence A-A-U-A-A-A is present in six different purified messenger RNA molecules (specifically the alpha-and beta-globulin mRNAs of rabbit and human, the immunoglobulin light chain mRNA of mouse (MOPC 21) and the ovalbumin mRNA of chicken) about 20 residues away from the 3'-terminal poly (A) sequence. In addition, a large selection of the 3' non-coding regions of rabbit and human globulin mRNAs (both the alpha and beta globin mRNAs) are 85% homologous, demonstrating that this region is significantly conserved in evolution.
mesh_terms: D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D002645:Chickens; D005914:Globins / Q000096:biosynthesis; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000096:biosynthesis; D051379:Mice; D009194:Myeloma Proteins / Q000096:biosynthesis; D010047:Ovalbumin / Q000096:biosynthesis; D011061:Poly A / Q000032:analysis; D012333:RNA, Messenger / Q000032:analysis*; D011817:Rabbits; D013045:Species Specificity
chemical_list: D007147:Immunoglobulin Light Chains; D009194:Myeloma Proteins; D012333:RNA, Messenger; D011061:Poly A; D005914:Globins; D010047:Ovalbumin