[Structural changes in motor endplates in frog muscle treated with vinblastine].
Two kinds of abnormalities have been observed in motor nerve endings of muscles soaked in vinblastine: the occurrence of paracrystalline structures, which could derive from the precipitation of one or several proteins in the axon terminal, and the presence of large vesicles, often of festooned shape. These abnormal vesicles seem to result from the fusion of synaptic vesicles and could explain the appearence of spontaneous giant potentials which are most probably produced by the release of big packets of ACh.
D000109:Acetylcholine; D000818:Animals; D009045:Motor Endplate / Q000187:drug effects* / Q000648:ultrastructure; D009469:Neuromuscular Junction / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects / Q000648:ultrastructure; D011893:Rana esculenta; D013572:Synaptic Vesicles / Q000187:drug effects / Q000648:ultrastructure; D014747:Vinblastine / Q000494:pharmacology*
D014747:Vinblastine; D000109:Acetylcholine
Modifications structurales des terminaisons motrices de muscles de grenouille soumis á l'action de la vinblastine