title: Structural homogeneity of human subacute sclerosing panencephalitis antibodies.
abstract: Three homogeneous immunoglobulin fractions were isolated from the serum of a patient with subacute sclerosing panencephalitis (SSPE). All three fractions reacted in immunodiffusion with measles and SSPE virus preparations. The amino-terminal sequence of the light and heavy chains of one of the antibody fractions was determined by automated Edman degradation. A single amino acid residue was obtained at every step, confirming the homogeneity of this human antibody.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000914:Antibodies, Viral / Q000302:isolation & purification*; D000937:Antigen-Antibody Reactions; D000956:Antigens, Viral; D002852:Chromatography, Ion Exchange; D004591:Electrophoresis, Polyacrylamide Gel; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007106:Immune Sera / Q000302:isolation & purification; D005779:Immunodiffusion; D007074:Immunoglobulin G / Q000302:isolation & purification; D007143:Immunoglobulin Heavy Chains / Q000302:isolation & purification; D007525:Isoelectric Focusing; D008459:Measles virus / Q000378:metabolism; D011817:Rabbits; D013344:Subacute Sclerosing Panencephalitis / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; D007106:Immune Sera; D007074:Immunoglobulin G; D007143:Immunoglobulin Heavy Chains