Adriamycin cardiomyopathy: enhanced cardiac damage in rabbits with combined drug and cardiac irradiation.
Rabbits received either (a) no treatment; (b) a single radiation dose; (c) protracted low-dose Adriamycin; (d) combined cardiac irradiation and low-dose Adriamycin; or (e) protracted high-dose Adriamycin. More severe myocardial lesions (similar to those in high-dose Adriamycin groups) developed in rabbits receiving combined treatment. Pericardial effusions and fibrosis were more common in the combined treatment group.
D000818:Animals; D004317:Doxorubicin / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006321:Heart / Q000187:drug effects / Q000528:radiation effects; D006331:Heart Diseases / Q000139:chemically induced / Q000209:etiology*; D008297:Male; D011817:Rabbits; D011882:Radiotherapy, High-Energy / Q000009:adverse effects*
D004317:Doxorubicin