Controlled field trials of killed oral typhoid and paratyphoid B vaccines and cell-free, chemical aerosol typhoid vaccine.
Three controlled field trials were carried out. One of them (1963) showed that an aerosol with cell-free, chemical typhoid  vaccine did not protect vaccinees from the disease. The other trials (1964 and 1965) assessing the efficacy of killed oral typhoid vaccine revealed a short term (up to 3 months) protective effect. In the trial of oral paratyphoid B vaccine no statistically significant difference in morbidity in the test and control groups was observed due to the small number of cases.
D000284:Administration, Oral; D000293:Adolescent; D000336:Aerosols; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D006801:Humans; D010284:Paratyphoid Fever / Q000517:prevention & control; D010919:Placebos; D014435:Typhoid Fever / Q000175:diagnosis / Q000517:prevention & control; D014436:Typhoid-Paratyphoid Vaccines / Q000008:administration & dosage* / Q000627:therapeutic use
D000336:Aerosols; D010919:Placebos; D014436:Typhoid-Paratyphoid Vaccines