title: Thyrotropin releasing hormone: development of inactivation system during maturation of the rat.
abstract: Whereas thyrotropin releasing hormone is rapidly and extensively degraded by plasma of adult rats, no appreciable loss of biological or immunological activity is caused by plasma from rats 4 or 16 days old. The plasma of neonatal rats does not appear to contain an inhibitor of thyrotropin releasing hormone peptidase or a peptidase with altered substrate affinity. The development of an active peptidase in rat plasma suggests a physiological role for inactivation of thyrotropin releasing hormone.
mesh_terms: D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn / Q000097:blood*; D010447:Peptide Hydrolases / Q000097:blood; D051381:Rats; D013973:Thyrotropin-Releasing Hormone / Q000097:blood* / Q000378:metabolism
chemical_list: D013973:Thyrotropin-Releasing Hormone; D010447:Peptide Hydrolases