[A molecular hybrid having gonadotropic activity in frogs composed of the alpha subunit of bovine luteinizing hormone and a subunit of a gonadotropin of a teleost fish].
The alpha subunit of bovine LH and the subunit SU II of carp gonadotropin are able to associate. The hybrid is about one hundred times less active than c-GTH or b-LH, respectively on goldfish and rat ovarian adenyl cyclase. However it is more efficient than both horomones on an Amphibian (Rana esculenta), on spermiation in vivo as well as on ovarian adenyl cyclase in vitro.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D005075:Biological Evolution; D002347:Carps; D002417:Cattle; D005260:Female; D006062:Gonadotropins / Q000494:pharmacology; D008297:Male; D010053:Ovary / Q000201:enzymology; D011487:Protein Conformation; D051381:Rats; D013045:Species Specificity; D013091:Spermatogenesis / Q000187:drug effects; D013329:Structure-Activity Relationship
D006062:Gonadotropins; D000262:Adenylyl Cyclases
Formation d'une molécule hybride douée d'une activité gonadotrope sur la grenouille, à partir de la sous-unité alpha de l'hormone lutéinisante bovine et d'une sous-unité de l'hormone gonadotrope d'un poisson téléostéen