Effect on primary Rh immunization of delayed administration of anti-Rh.
An intramuscular injection of 100 mug of anti-Rh, given 13 days after an intravenous injection of 1 ml of Rh-positive red cells appeared to suppress primary Rh immunization: at 6 months, none of thirteen subjects so treated had detectable anti-Rh in their plasma, whereas anti-Rh was present in five out of twelve control subjects injected with Rh-positive cells alone (P equals 0.015, Fisher's exact test, one-tailed). Primary immunization was not suppressed in all treated subjects since, following a second injection of Rh-positive cells, 7-day survival was subnormal in three subjects, all of whom had anti-Rh in their plasma after a further 2 weeks. In three other treated subjects, primary Rh immunization appeared to be completely suppressed: survival was normal, or initially normal, following a second injection of Rh-positive cells and anti-Rh was detectable only after a third injection.
D000917:Antibody Formation; D002470:Cell Survival; D002860:Chromium Radioisotopes; D004912:Erythrocytes / Q000276:immunology; D006801:Humans; D007114:Immunization; D007116:Immunization, Passive; D007165:Immunosuppression Therapy; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D007518:Isoantibodies / Q000008:administration & dosage* / Q000096:biosynthesis; D008297:Male; D012204:Rh-Hr Blood-Group System; D013997:Time Factors
D002860:Chromium Radioisotopes; D007518:Isoantibodies; D012204:Rh-Hr Blood-Group System