On the mode of action of hydroxyproline in Drosophila development.
Hydroxyproline (OHP) fed to Drosophila larvae is known to impair the ability of pupae to evert cephalic structures and leg and wing discs. In order to gain insight into the metabolic basis of OHP action we have investigated the effects of combined feeding of OHP and several compounds. Proline, glucosamine HCl, and N-acetyl glucosamine considerably reduced the extent of morphological defects of OHP, while alanine and sodium glutamate were less effective. Glutamine and glutathione did not reduce the effects of OHP. The results are consistent with the hypothesis that OHP may indirectly interfere with cuticle synthesis.
D000117:Acetylglucosamine / Q000494:pharmacology; D000409:Alanine / Q000494:pharmacology; D000818:Animals; D004331:Drosophila melanogaster / Q000187:drug effects* / Q000254:growth & development; D005944:Glucosamine / Q000494:pharmacology; D005971:Glutamates / Q000494:pharmacology; D005973:Glutamine / Q000494:pharmacology; D005978:Glutathione / Q000494:pharmacology; D006909:Hydroxyproline / Q000494:pharmacology*; D009154:Mutation; D010641:Phenotype; D011392:Proline / Q000494:pharmacology
D005971:Glutamates; D005973:Glutamine; D011392:Proline; D005978:Glutathione; D005944:Glucosamine; D000409:Alanine; D006909:Hydroxyproline; D000117:Acetylglucosamine