Effects of exygen-nitrogen (1:1) at 760 Torr on the life span and fine structure of Drosophila melanogaster.
Exposure of Drosophila melanogaster adult males to an atmosphere of O2-N2 (1:1) at 760 Torr resulted in a marked reduction of life span. Among the fine structural changes occurring in the oxygen-poisoned flies, the following were similar to age-related changes: ceroid-lipofuscin accumulation in the visceral organs, sponginess of the brain and accumulation of lamellated dense bodies in the nerve cells. Also, the oxygen-poisoned flies showed a loss of the cytoplasmic membranes of the sperm cells, an alteration which was previously found in y-irradiated, but not in normal senescent, flies. In our opinion, oxygen poisoning of Drosophila may provide a valid model of accelerated aging, at least in regard to peroxidation injury of cell organelles and ceroid-lipofuscin accumulation.
D000375:Aging; D000818:Animals; D001274:Atmospheric Pressure; D001921:Brain / Q000648:ultrastructure; D004331:Drosophila melanogaster / Q000187:drug effects* / Q000648:ultrastructure; D008136:Longevity / Q000187:drug effects*; D008297:Male; D008317:Malpighian Tubules / Q000648:ultrastructure; D008854:Microscopy, Electron; D008954:Models, Biological; D009584:Nitrogen / Q000494:pharmacology*; D010100:Oxygen / Q000506:poisoning*; D012669:Seminal Vesicles / Q000648:ultrastructure; D013737:Testis / Q000648:ultrastructure
D009584:Nitrogen; D010100:Oxygen