title: Chloramine mutagenesis in Bacillus subtilis.
abstract: Chloramine (which occurs widely as a by-product of sanitary chlorination of water supplies) is shown to be a weak mutagen, when reversion of trpC to trpC in Bacillus subtilis is used as an assay. Some DNA-repair mutants appear to be more sensitive to chloramine, suggesting the involvement of DNA targets in bactericide. The influence of plating media on survival of cells treated with chloramine suggests a bacterial repair system acting upon potentially lethal lesions induced by chloramine.
mesh_terms: D001412:Bacillus subtilis / Q000528:radiation effects; D002700:Chloramines; D004260:DNA Repair; D009153:Mutagens; D011830:Radiation Effects; D014466:Ultraviolet Rays; D014881:Water Supply
chemical_list: D002700:Chloramines; D009153:Mutagens