Contagious bovine pleuropneumonia: mouse-protective antibody in the sera of infected and vaccinated cattle.
Cattle produced humoral mouse-protective antibody (MPA) to Mycoplasma mycoides var mycoides as a result of natural infection, hyperimmunisation, vaccination with well-known strains of living vaccines or vaccination with killed cultures. Bovine MPA was distinct from complement-fixing and precipitating antibodies and was frequently detected in their absence, particularly in the sera of vaccinated--as opposed to naturally infected--cattle. In view of its defensive role in artificially-infected mice, it seems likely that such antibody plays a part in resistance to the disease in cattle. High levels of MPA followed inoculation of cattle with killed concentrated culture containing adjuvant; this finding merits further investigation, as it may lead to improved methods of vaccination.
D000818:Animals; D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines / Q000008:administration & dosage; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology*; D003168:Complement Fixation Tests; D005260:Female; D005620:Freund's Adjuvant / Q000008:administration & dosage; D006358:Hot Temperature; D007106:Immune Sera / Q000008:administration & dosage; D007116:Immunization, Passive; D005779:Immunodiffusion; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D008297:Male; D051379:Mice / Q000276:immunology; D009175:Mycoplasma Infections / Q000662:veterinary*; D009176:Mycoplasma mycoides / Q000276:immunology*; D011002:Pleuropneumonia, Contagious / Q000276:immunology / Q000662:veterinary*; D014611:Vaccination / Q000662:veterinary
D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D007106:Immune Sera; D005620:Freund's Adjuvant