Acute haemolytic anaemia due to IgM penicillin antibody in a 3-year-old child: a sequel to oral penicillin.
A hitherto undescribed form of immune haemolytic anaemia due to penicillin antibody is described. The antibody, which was of the IgM class, fixed complement and caused acute haemolysis. Oral penicillin seems to have been responsible both for antibody production and, on subsequent exposure, for the haemolytic anaemia.
D000284:Administration, Oral; D000743:Anemia, Hemolytic / Q000139:chemically induced* / Q000276:immunology; D000917:Antibody Formation; D000941:Antigens; D002675:Child, Preschool; D003168:Complement Fixation Tests; D003298:Coombs Test; D006801:Humans; D007106:Immune Sera; D007075:Immunoglobulin M; D008297:Male; D010404:Penicillin V / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology; D012141:Respiratory Tract Infections / Q000188:drug therapy
D000941:Antigens; D007106:Immune Sera; D007075:Immunoglobulin M; D010404:Penicillin V