Potential antiinflammatory agents N-carboxyalkyl derivatives of barbituric acid.
The synthesis and investigation of the structure of N-carboxyalkyl derivatives of barbituric acids are described. In the solid state 3-carboxymethyl-1-phenylbarbitone has the structure of a hemiketal, the corresponding 1-cyclohexyl derivative was not cyclized to the hemiketal and 3-carboxymethyl-5-ethyl-1-phenylbarbituric acid was a mixture of the cyclized and open structures. Some of the compounds were found to be very weak inhibitors of prostaglandin synthetase.
D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis*; D001463:Barbiturates / Q000138:chemical synthesis*; D016861:Cyclooxygenase Inhibitors
D000893:Anti-Inflammatory Agents; D001463:Barbiturates; D016861:Cyclooxygenase Inhibitors