Studies on the mechanism of macrophage-mediated cytotoxicity.
MCF is a product of sensitized T lymphocytes, which is actively synthesized and secreted when lymphocytes are incubated with the appropriate target cells. The process of macrophage activation leading to cytotoxicity needs a period of 24h. Macrophage-mediated cytotoxicity is restricted to the specific target cell. B cell antibody does not seem to be involved. The reaction cannot be inhibited by rabbit antimouse immunoglobulin. However, various conditions, which may interfere with this specificity, are discussed.
D000042:Absorption; D000818:Animals; D000918:Antibody Specificity; D001202:Ascitic Fluid / Q000166:cytology; D002458:Cell Fractionation; D002478:Cells, Cultured; D002860:Chromium Radioisotopes; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D005347:Fibroblasts; D007106:Immune Sera; D007700:Kinetics; D008223:Lymphoma / Q000276:immunology; D008264:Macrophages / Q000276:immunology*; D012515:Mast-Cell Sarcoma / Q000276:immunology; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008970:Molecular Weight; D011817:Rabbits / Q000276:immunology; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000276:immunology; D014357:Trypsin
D002860:Chromium Radioisotopes; D007106:Immune Sera; D014357:Trypsin