Lipiarmycin, a new antibiotic from Actinoplanes.  II. Isolation, chemical, biological and biochemical characterization.
Lipiarmycin, a metabolite of Actinoplanes deccanensis nov. sp. (PARENTI et al.), has been isolated in pure form.  It has a molecular formula C52 CONGRUENT TO 54H74 CONGRUENT TO 76Cl2O19, (M.W. = 1,073 CONGRUENT TO 1,099).  From its chemical and physico-chemical characteristics, lipiarmycin can be considered a new antibiotic.  Lipiarmycin is highly active against Gram-positive bacteria, including strains resistant to the medically important antibiotics and protects mice experimentally infected with Streptococcus haemolyticus.  Liparmycin inhibits growth of susceptible bacteria by interfering with RNA synthesis.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000494:pharmacology / Q000633:toxicity; D001412:Bacillus subtilis / Q000378:metabolism; D001419:Bacteria / Q000187:drug effects; D001426:Bacterial Proteins / Q000096:biosynthesis; D055598:Chemical Phenomena; D002621:Chemistry; D002713:Chlorine / Q000032:analysis; D002854:Chromatography, Paper; D002855:Chromatography, Thin Layer; D004269:DNA, Bacterial / Q000096:biosynthesis; D003773:Dental Plaque / Q000517:prevention & control; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D012329:RNA, Bacterial / Q000096:biosynthesis; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013291:Streptococcus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D004269:DNA, Bacterial; D012329:RNA, Bacterial; D002713:Chlorine