title: The effect of helium and of hydrogen at high pressure on the cell division of Tetrahymena pyriformis W.
abstract: The rate of cell division of Tetrahymena growing in an observational high pressure vessel was measured at selected pressures of helium, hydrogen and at high hydrostatic pressure. Pressures greater than 100 atm reduced the rate of division, but the gases inhibited division to a lesser degree than pure hydrostatic pressure. Hydrogen's effect was distinguishable from that of hydrostatic pressure at 130 atm or more, while helium's effect appeared at 175 atm. These inert gases probably counteract the action of pressure by stabilising apolar pressure-labile targets.
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D006371:Helium / Q000494:pharmacology*; D006859:Hydrogen / Q000494:pharmacology*; D006874:Hydrostatic Pressure; D008433:Mathematics; D008829:Microbiology / Q000295:instrumentation; D010313:Partial Pressure; D011312:Pressure; D013696:Temperature; D013769:Tetrahymena pyriformis / Q000187:drug effects / Q000254:growth & development / Q000502:physiology*
chemical_list: D006371:Helium; D006859:Hydrogen