title: [Therapy of early symptoms of radiation sickness in dogs using Pyrimetin].
abstract: The antiemetic effect of Pyrimetin (V.V.M.I.) in dogs whose whole body had been irradiated with gamma rays with the dose of 500 R, administred per os, intramuscularly, and subcutaneously, immediately before the exposure and after it in the course of the initial symptoms of the radiation sickness was studied. Decreased emesis occurred after per os administration of Pyrimetin immediately before the whole body irradiation of the dogs. After an intramuscular application before the whole body irradiation two dogs vomitted, and in the case of an i.m. administration after the whole body irradiation one dog vomitted. Subcutaneous application of Pyrimetin to dogs before the whole body irradiation and also after it produced only a 30 p.c. therapeutic effect.
mesh_terms: D000208:Acute Disease; D000818:Animals; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D011832:Radiation Injuries / Q000662:veterinary*; D011837:Radiation-Protective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors; D014839:Vomiting / Q000662:veterinary
chemical_list: D011837:Radiation-Protective Agents
vernacular_title: Terapie casných príznakŭ nemoci z ozárení u psů pyrimetinem