Enhancement of mammary tumor formation in mice by a cytostatic drug, melphalan.
Melphalan (L-phenylalanine mustard), a cytostatic drug used in treatment of human breast cancer, was injected into mice bearing preneoplastic hyperplastic alveolar nodule mammary outgrowth line D2. Melphalan, doses of either 2.5 or 5.0 mg/kg, markedly enhanced tumor formation in its mammary nodule outgrowth line. Samples of nodule outgrowths in untreated mice produced 13% tumors by 9 months after transplantation, whereas nodule outgrowths in melphalan-treated mice produced 57 and 85% mammary tumors in the lower and higher dose groups, respectively.
D000818:Animals; D002273:Carcinogens; D005260:Female; D006801:Humans; D006965:Hyperplasia; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced* / Q000209:etiology; D008558:Melphalan / Q000008:administration & dosage / Q000009:adverse effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D011230:Precancerous Conditions; D013268:Stimulation, Chemical
D002273:Carcinogens; D008558:Melphalan