DMBA-induced mammary tumours in locally irradiated rats.
Local X-ray irradiation (400 r) covering 3 abdominal mammary glands revealed no tumours in the irradiated region after 10 months. A similar irradiation 1 or 10 days prior to i.v. DMBA showed a significant increase of tumours in the irradiated region, as compared with the contralateral abdominal region. The two thoracic regions, however, still had a very high tumour incidence. This was equal to, or even higher than that of the irradiated area. The same pattern also prevailed in animals receiving extra-mammary irradiation.  The significance of early local factors in carcinogenesis is stressed.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000009:adverse effects*; D000818:Animals; D001551:Benz(a)Anthracenes / Q000009:adverse effects*; D005260:Female; D005552:Forelimb / Q000528:radiation effects; D006257:Head / Q000528:radiation effects; D006614:Hindlimb / Q000528:radiation effects; D008321:Mammary Glands, Animal / Q000528:radiation effects*; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced*; D009381:Neoplasms, Radiation-Induced; D011830:Radiation Effects; D051381:Rats
D001551:Benz(a)Anthracenes; D015127:9,10-Dimethyl-1,2-benzanthracene