Experimental polymer storage disease in rabbits. An approach to the histogenesis of sphingolipidoses.
Water-soluble polymer compound, polyvinyl alcohol(PVA), and water-insoluble polymer compounds, polyvinyl acetate (PVAc) and polystylol (PS), were administered in 297 rabbits. When high polymerized PVA, PVAc or PS were continuously injected intravenously for a long period of time, lesions resembled to those of Gaucher and Niemann-Pick diseases were developed. From these experimental results, pathological development of various sphingolipidoses found in the human body was discussed and pathological findings were analysed polymer-chemically from the chemical properties of the substances stored.
D000818:Animals; D001853:Bone Marrow / Q000473:pathology; D000795:Fabry Disease / Q000473:pathology; D005776:Gaucher Disease / Q000473:pathology; D006801:Humans; D007275:Injections, Intravenous; D008099:Liver / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D012157:Mononuclear Phagocyte System / Q000473:pathology; D009542:Niemann-Pick Diseases / Q000473:pathology; D011142:Polyvinyl Alcohol; D011145:Polyvinyls; D011817:Rabbits; D013106:Sphingolipidoses / Q000139:chemically induced / Q000473:pathology*; D013154:Spleen / Q000473:pathology; D013997:Time Factors
D011145:Polyvinyls; D011142:Polyvinyl Alcohol