title: [Studies on the distribution of thienylcarbenicillin in the human tissue].
abstract: Thienylcarbenicillin is another semisynthetic penicillin with a wide range of antibacterial activity including most of gram-negative bacterias, even such as Pseudomonas aeruginosa. To investigate penetration activities into bone and another tissues, 120 specimens of serum and 120 specimens of tissue were obtained from 20 patients, after i.v. injection of a single doses of 150 mg thienylcarbenicillin per kg body weight. The evaluation of concentration showed that Thienylcarbenicillin was eliminated from serum in a half-life time of 77 minutes. The concentration varied in different tissues. Maximal levels were found in musculature and in spongy bone. Unexpected high concentrations were found in fascia and in cutis. The lowest concentration was found in subcutis and compact bone. The experimental doses of 150 mg/kg body weight was not enough to gain a sufficient therapeutical level in compact bone.
mesh_terms: D000328:Adult; D000368:Aged; D002228:Carbenicillin / Q000031:analogs & derivatives / Q000378:metabolism* / Q000494:pharmacology / Q000627:therapeutic use; D004341:Drug Evaluation; D004926:Escherichia coli / Q000187:drug effects; D005260:Female; D006193:Haemophilus influenzae / Q000187:drug effects; D006621:Hip Joint / Q000601:surgery; D006801:Humans; D007592:Joint Diseases / Q000601:surgery; D007595:Joint Prosthesis; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000188:drug therapy; D011513:Proteus mirabilis / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects
chemical_list: D002228:Carbenicillin
vernacular_title: Untersuchungen über die Verteilung von Thienylcarbenicillin in menschlichen Geweben