[Immunoglobulin D. Physiology and pathology excluding myeloma].
Immunoglobulin D is the fourth class of immunoglobulins secreted by the plasma cells and also, in 5% of lymphocytes, this is a surface immunoglobulin. Its serum levels are about 0.03 mg/ml, due to low secretion, intersititial diffusion and intense catabolism. IgD migrates on electrophoresis in the beta-gamma zone, on immuno-electrophoresis, in the beta2 zone. Only one disulphide bridge links the delta-chains together. The light chains, are, in most cases, lambda chain. Studies of the antigenic characteristics of the delta-chains are in progress. IgD does not take up complement, but has an antibody function. 37% of healthy subjects have anti IgD antibodies. Only 4 cases of monoclonal IgD gammopathy without malignant myeloma, have been reported. Anto-antibodies of IgD nature have been described in various connective tissue diseases or auto-immune processes.
D001327:Autoimmune Diseases / Q000503:physiopathology; D002462:Cell Membrane / Q000276:immunology; D006801:Humans; D006942:Hypergammaglobulinemia / Q000503:physiopathology; D007122:Immunoelectrophoresis; D007072:Immunoglobulin D / Q000032:analysis / Q000502:physiology; D007128:Immunoglobulin Fragments; D007143:Immunoglobulin Heavy Chains; D007146:Immunoglobulin lambda-Chains; D008970:Molecular Weight
D007072:Immunoglobulin D; D007128:Immunoglobulin Fragments; D007143:Immunoglobulin Heavy Chains; D007146:Immunoglobulin lambda-Chains
L'immunoglobuline D. Physiologie et pathologie en dehors du myélome