Hemangioma of the choroid. A clinicopathologic study of 71 cases and a review of the literature.
This is a clinicopathologic study of 71 hemangiomas of the choroid. The cases were divided into three groups: Group 1 consisted of 45 cases of solitary choroidal hemangiomas (not related to any systemic disease); Group 2 comprised 17 cases with unequivocal evidence of Sturge-Weber syndrome; and Group 3 included 9 cases, 6 of which were classified as "probably Sturge-Weber syndrome." Clinically, many differences were found that established a clear distinction between Groups 1 and 2. Histopathologically, the solitary hemangiomas were well-circumscribed tumors that showed a sharply demarcated pushing margin causing compression of melanocytes and choroidal  lamellae. About 70% of these tumors were located temporally (at the posterior pole). In contrast, the lesions in the Sturge-Weber syndrome showed a diffuse angiomatosis involving more than one-half of the choroid, as well as the episcleral and intrascleral perilimbal plexuses. The cause and pathogenesis of these lesions are discussed.
D000367:Age Factors; D000798:Angiomatosis / Q000473:pathology*; D002648:Child; D002829:Choroid / Q000473:pathology*; D002830:Choroid Neoplasms / Q000473:pathology*; D005260:Female; D005901:Glaucoma / Q000151:congenital; D006391:Hemangioma / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009887:Ophthalmoscopy; D009898:Optic Disk / Q000473:pathology; D009999:Ossification, Heterotopic / Q000473:pathology; D012160:Retina / Q000473:pathology; D012174:Retinitis Pigmentosa / Q000473:pathology; D012737:Sex Factors; D013341:Sturge-Weber Syndrome / Q000473:pathology; D014794:Visual Fields