title: A brief argument in opposition to the Orgel hypothesis.
abstract: The Orgel hypothesis receives considerable attention as a possible explanation for the phenomenon of senescence. Experimental observations which argue in favor of the Orgel hypothesis are discussed, and critized in part. This is followed by a presentation of experimental data which argue in opposition to the notion. On the basis of the considerable body of data which argue in opposition to the Orgel theory, a call for reappraisal of the applicability of this theory to the phenomenon of senescence is suggested.
mesh_terms: D000375:Aging; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D003429:Cross Reactions; D004330:Drosophila / Q000502:physiology; D004798:Enzymes / Q000378:metabolism*; D005260:Female; D005347:Fibroblasts / Q000201:enzymology; D005634:Fructose-Bisphosphate Aldolase / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D005958:Glucosephosphates / Q000378:metabolism; D006358:Hot Temperature; D006801:Humans; D008099:Liver / Q000201:enzymology; D008168:Lung / Q000196:embryology; D008190:Lyases / Q000378:metabolism; D008297:Male; D009251:NADPH-Ferrihemoprotein Reductase / Q000378:metabolism; D009348:Nematoda / Q000201:enzymology; D011247:Pregnancy; D014176:Protein Biosynthesis
chemical_list: D000596:Amino Acids; D004798:Enzymes; D005958:Glucosephosphates; D005954:Glucosephosphate Dehydrogenase; D009251:NADPH-Ferrihemoprotein Reductase; D008190:Lyases; D005634:Fructose-Bisphosphate Aldolase