Assessment of anti-inflammatory drugs in the rat using subcutaneous implants of polyurethane foam impregnated with dead tubercle bacilli.
The fluid and cellular phases of inflammatory resonse have been measured using a technique employing subcutaneous implantation of polyurethane foam cubes impregnated with heat-killed Mycobacterium tuberculosis. Phenylbutazone, azathioprine, aspirin, cyclophosphamide, and prednisolone suppressed fluid response, whereas sodium aurothiomalate, hydroxychloroquine, and D-penicillamine had no effect. All the drugs used suppressed the infiltration of inflammatory cells into the cubes.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001241:Aspirin / Q000627:therapeutic use; D001379:Azathioprine / Q000627:therapeutic use; D001681:Biological Assay; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D006052:Gold Sodium Thiomalate / Q000627:therapeutic use; D006886:Hydroxychloroquine / Q000627:therapeutic use; D007249:Inflammation / Q000517:prevention & control; D009169:Mycobacterium tuberculosis; D010396:Penicillamine / Q000627:therapeutic use; D010653:Phenylbutazone / Q000627:therapeutic use; D011140:Polyurethanes; D011239:Prednisolone / Q000627:therapeutic use; D051381:Rats
D000893:Anti-Inflammatory Agents; D011140:Polyurethanes; D006052:Gold Sodium Thiomalate; D006886:Hydroxychloroquine; D003520:Cyclophosphamide; D011239:Prednisolone; D010653:Phenylbutazone; D010396:Penicillamine; D001379:Azathioprine; D001241:Aspirin