title: Creatine kinase isoenzymes in baboon tissues and organs.
abstract: We determined the activity of the isoenzymes of creatine kinase in homogenates of fresh tissues from six baboons. Twenty-six tissues were removed from each baboon and the isoenzymes in them were separated by chromatography on diethylaminoethyl-Sephadex A-50. Total activity was greatest in skeletal muscle (2600 U/g wet weight) followed by myocardium (800 U/g), brain (180 U/g), and the bladder and tissues of the gastrointestinal tract (about 100 U/g). Ten tissues had total activities of less than 20 U/g: trachea, lung, kidney, thyroid, gall bladder, liver, spleen, pancreas, common bile duct, and adrenal. Skeletal muscle contained only the MM isoenzyme; myocardium contained 81% MM isoenzyme, 18% MB isoenzyme, and 1% BB isoenzyme. Except for thyroid and pancreas, all other tissues contained mainly the BB isoenzyme. Tissues of the gastrointestinal tract contained significant (7 to 17%) MB isoenzyme activity.
mesh_terms: D000818:Animals; D001921:Brain / Q000201:enzymology; D003402:Creatine Kinase / Q000032:analysis*; D004064:Digestive System / Q000201:enzymology; D005704:Gallbladder / Q000201:enzymology; D000882:Haplorhini; D007082:Ileum / Q000201:enzymology; D007527:Isoenzymes / Q000032:analysis*; D008297:Male; D009132:Muscles / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology; D009928:Organ Specificity; D010215:Papio; D011467:Prostate / Q000201:enzymology
chemical_list: D007527:Isoenzymes; D003402:Creatine Kinase