[Comparative subcellular localization of para-hydroxylated derivatives of ephedrine and amphetamine in rat brain].
Localisation of noradrenaline, hydroxyamphetamine, hydroxynorephedrine and hydroxyephedrine was studied in adrenergic granules of rat's brain in normal animals and in animals injected with hydroxy-6 dopamine. In normal animals the synaptosomes fixed noradrenaline, first and then, in decreasing order, hydroxynorephedrine, hydroxyephedrine and hydroxyamphetamine. Hydroxy-6 dopamine injection resulted in a decrease of fixation by synaptosomes, thus confirming the role of central false-transmitters of hydroxylated derivatives of amphetamine and ephedrine.
D000662:Amphetamines / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D004809:Ephedrine / Q000031:analogs & derivatives* / Q000378:metabolism; D006892:Hydroxydopamines / Q000494:pharmacology; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D010665:Phenylpropanolamine / Q000031:analogs & derivatives*; D051381:Rats; D013574:Synaptosomes / Q000378:metabolism; D010136:p-Hydroxyamphetamine / Q000378:metabolism*; D010137:p-Hydroxynorephedrine / Q000378:metabolism*
D000662:Amphetamines; D006892:Hydroxydopamines; D010665:Phenylpropanolamine; D010137:p-Hydroxynorephedrine; D010136:p-Hydroxyamphetamine; D004809:Ephedrine; D009638:Norepinephrine
Localisation subcellulaire centrale comparée des dérivés p hydroxylés de l'éphédrine et de l'amphétamine dans le cerveau du rat