[Prevention of infection in patients with agranulocytosis through isolation and whole-body decontamination].
During induction chemotherapy 21 patients with acute myelogenous leukemia and agranulocytosis were prophylactically isolated either in reverse isolation (group A) or in sterile plastic-tent isolators with laminar air flow (Life Islands, group B). Patients of group B also received whole-body decontamination and sterile food. Life threatening septicemias were seen only in patients in reverse isolation. Granulocyte transfusions were highly successful in reducing infection-related mortality in group A. Seven additional patients with agranulocytosis of varying origin (group C) were protected in the Life Islands as effectively as the patients with acute leukemia.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000380:Agranulocytosis / Q000150:complications* / Q000209:etiology; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D005516:Food Microbiology; D006801:Humans; D017053:Infection Control; D015470:Leukemia, Myeloid, Acute / Q000150:complications*; D008875:Middle Aged; D010357:Patient Isolators; D018805:Sepsis / Q000517:prevention & control
D000900:Anti-Bacterial Agents
Infektprophylaxe bei Patienten mit Agranulozytose durch Isolation und Ganzkörperdekontamination