Incidence, growth and antigenicity of fibrosarcomas induced by Teflon disc in mice.
Subcutaneous sarcomas were induced in BALB/c, C3Hf/Dp, and C57BL/He female mice by implantation of a Teflon disc or by injection of 7,12-dimethylbenz (a) anthracene (DMBA). The incidence of DMBA tumors was homogeneously high (60-86%) in the 3 strains, and the latency varied from 16 to 26 weeks from treatment. Teflon-induced tumors developed, in the BALB/c, C3Hf/Dp, C57BL/He mice, in 44, 94, and 30%, with a mean latency of 78, 61, and 82 weeks respectively. Evaluation of the growing capacity of 4 DMBA-induced and 14 Teflon-induced fibrosarcomas at the first and second transplant passage showed that Teflon tumors grew faster and needed a smaller cell dose to take than the DMBA tumors. Transplantation type antigens were detected only on the chemically induced tumors. Cross-reacting antigens were detected on 3 of the 5 Teflon-induced tumors by an in vitro assay for cell-mediated cytotoxicity.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D000951:Antigens, Neoplasm; D003429:Cross Reactions; D003601:Cytotoxicity Tests, Immunologic; D004622:Embryo, Mammalian / Q000276:immunology; D005260:Female; D005354:Fibrosarcoma / Q000209:etiology / Q000276:immunology / Q000473:pathology; D006649:Histocompatibility Antigens; D007111:Immunity, Cellular; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D011138:Polytetrafluoroethylene; D012513:Sarcoma, Experimental / Q000209:etiology / Q000276:immunology / Q000473:pathology; D013997:Time Factors
D000951:Antigens, Neoplasm; D006649:Histocompatibility Antigens; D015127:9,10-Dimethyl-1,2-benzanthracene; D011138:Polytetrafluoroethylene