title: Onset of cell proliferation in the shortened gut. Colonic hyperplasia after ileal resection.
abstract: Cytokinetics in colonic mucosa were studied after ileal resection in young female rats. The RNA content of the transverse colon was increased 32% after 7 days; after 14 days the increase was present throughout the colon. The DNA content of the ascending colon increased 29% after 10 days. Specific activity of DNA labeled with [3H-methyl]thymidine was elevated 29% in the ascending colon and elevated 49% in the descending colon on the 7th postoperative day. Colonic cell proliferation is stimulated within 1 week of ileal resection.
mesh_terms: D000818:Animals; D001345:Autoradiography; D001835:Body Weight; D003106:Colon / Q000473:pathology*; D004247:DNA / Q000378:metabolism; D005260:Female; D006965:Hyperplasia / Q000209:etiology; D007082:Ileum / Q000378:metabolism / Q000601:surgery*; D012313:RNA / Q000378:metabolism; D051381:Rats
chemical_list: D012313:RNA; D004247:DNA