Chemistry of technetium radiopharmaceuticals. I. Exploration of the tissue distribution and oxidation state consequences of technetium (IV) in Tc-Sn-gluconate and Tc-Sn-EHDP using carrier 99Tc.
The distribution in rats of the renal agent Tc-Sn-gluconate using both 99mTc and carrier amounts of 99Tc was similar. The same behavior was shown with the bone agent Tc-Sn-EHDP. The radiopharmaceutical consequences of the observed Tc(IV) oxidation state in these systems are explored.
D000818:Animals; D012968:Etidronic Acid / Q000378:metabolism*; D005269:Femur / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism; D005942:Gluconates / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism; D009943:Organophosphorus Compounds / Q000378:metabolism*; D010084:Oxidation-Reduction; D051381:Rats; D013667:Technetium / Q000378:metabolism*; D014001:Tin / Q000378:metabolism*
D005942:Gluconates; D009943:Organophosphorus Compounds; D013667:Technetium; D014001:Tin; D012968:Etidronic Acid