title: 5-thio-D-glucose: o-diphenoloxidase inhibition as its mechanism of action.
abstract: 5-Thio-D-glucose completely inhibited o-diphenoloxidase from animal as well as plant sources. It has been reported that thioglucose suppresses spermatogenesis in mice and also insect metamorphosis, probably through inhibition of glucose transport. Inhibition of o-diphenoloxidase (which is active in spermatozoa and insect larvae) is suggested as an alternative mechanism of action of thioglucose.
mesh_terms: D001487:Basidiomycota / Q000201:enzymology; D004156:Catechol Oxidase / Q000037:antagonists & inhibitors*; D002478:Cells, Cultured; D004295:Dihydroxyphenylalanine / Q000378:metabolism; D005947:Glucose / Q000031:analogs & derivatives* / Q000494:pharmacology; D066298:In Vitro Techniques; D008545:Melanoma / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects
chemical_list: C003002:5-thio-D-glucose; D004295:Dihydroxyphenylalanine; D004156:Catechol Oxidase; D005947:Glucose