Studies on the antibody response to E. Coli O-antigens in children with urinary tract infections.
A passive haemagglutination technique was used to measure the E. coli antibody response in children with acute and chronic urinary tract infections with or without renal involvement. The E. coli antibody titre was also determined in sera of control normal children. In acute infections with renal involvement there was markedly high antibody response whereas in acute infections without renal involvement the rise in the antibody response to E. coli was only slight. In patients with chronic pyelonephritis the titres were also markedly high. E. coli antigens from 3 different sources were used in an attempt to find a substitute antigen for cases with negative urinary cultures. The 3 antigens used were urinary strains (only in patients with positive urinary cultures), patient's faecal strain and a polyvalent standard E. coli antigen. The faecal antigens gave results similar to the urinary ones in only 52% while the polyvalent antigen was found to be a more valuable substitute antigen giving equal titres to those with the urinary antigens in about 63% of the cases.
D000208:Acute Disease; D000937:Antigen-Antibody Reactions; D000942:Antigens, Bacterial; D001424:Bacterial Infections / Q000175:diagnosis / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D003937:Diagnosis, Differential; D004926:Escherichia coli / Q000276:immunology*; D006386:Hemagglutination Tests; D006801:Humans; D007223:Infant; D011704:Pyelonephritis / Q000175:diagnosis / Q000276:immunology; D014552:Urinary Tract Infections / Q000175:diagnosis / Q000276:immunology*
D000942:Antigens, Bacterial