[Prolactinemia in primary hypothyroïdism : basal and dynamic studies--signification of galactorrhea associated with myxedema (author's transl)].
PRL and TSH were measured by radioimmuno-assay in 14 persons wth myxoedema aged 16 to 65 years. Three of them had galactorrhea. In 13 patients the circadian rhythm of PRL was studied, and in 8 patients PRL was measured after TRH administration. All these patients have a high value of serum TSH, with a mean value +/- SEM of 29,4 (24,3 - 35,6) mU/ml. Values of serum PRL were comprised in normal ranges with a mean value +/- SEM of 126(196 - 238) mU/ml. The circadian rhythm of PRL is not altered, since mean values of serum PRL are more elevated at 4 am than 8 am with highly statistical significance. After THR administration the PRL response is normal or exaggerated.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002940:Circadian Rhythm; D005260:Female; D005687:Galactorrhea / Q000097:blood / Q000209:etiology*; D006801:Humans; D007775:Lactation Disorders / Q000209:etiology*; D008875:Middle Aged; D009230:Myxedema / Q000097:blood* / Q000150:complications; D011247:Pregnancy; D011388:Prolactin / Q000097:blood*; D013972:Thyrotropin / Q000097:blood*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology
D013973:Thyrotropin-Releasing Hormone; D011388:Prolactin; D013972:Thyrotropin
La prolactinémia chez les myxoedémateuses. Etude statique et dynamique, son rôle dans le syndrome hypothyroïdie-galactorrhée