[Transmembrane exchange of C1- and HCO3- in erythrocytes: direct action of carbonic anhydrase inhibitors on the transport mechanism].
The only currently recognised role of unsubstituted sulphonamides is their specific inhibition of carbonic anhydrase. The results presented here show that they inhibit the HCO3/Cl- and Cl-/Cl- exchanges across the membrane of the ox erythrocyte. Carbonic anhydrase is not involved in this inhibition which is the result of a direct and specific action on the anion transfer mechanism at membrane level. This newly-recognised role of sulphonamides satisfactorily explains and integrates many experimental results concerning secretory tissues and the interpretation of the action of diuretics.
D000818:Animals; D001574:Benzolamide / Q000494:pharmacology*; D001639:Bicarbonates / Q000097:blood*; D002256:Carbonic Anhydrases / Q000494:pharmacology*; D002417:Cattle; D002462:Cell Membrane / Q000187:drug effects; D002463:Cell Membrane Permeability; D002712:Chlorides / Q000097:blood*; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D013830:Thiadiazoles / Q000494:pharmacology*
D001639:Bicarbonates; D002712:Chlorides; D013830:Thiadiazoles; D002256:Carbonic Anhydrases; D001574:Benzolamide
Les échanges transmembranaires de C1- et de HCO3- dans le globule rouge: mise en évidence d'une action directe des inhibiteurs de l'anhydrase carbonique sur le mécanisme de transfert