Calcium-dependent stimulation of erythrocyte membrane phospholipid fatty acid incorporation by the ionophore A23187.
Treatment of human erythrocytes with A23187, a divalent cation ionophore, results in a calcium-dependent increase in the rate of incorporation of palmitic, oleic, and linoleic acids into phosphatidylethanolamine. Incorporation of fatty acids into phosphatidylcholine is unaffected by A23187. This calcium-dependent stimulation of membrane phosphatidylethanolamine fatty acid turnover by A23187 may be related to the changes in erythrocyte membrane function induced by A23187 that have been observed previously.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000001:Calcimycin / Q000494:pharmacology*; D002118:Calcium / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D004533:Egtazic Acid / Q000494:pharmacology; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D005227:Fatty Acids / Q000097:blood*; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D010713:Phosphatidylcholines / Q000096:biosynthesis; D010714:Phosphatidylethanolamines / Q000096:biosynthesis; D010743:Phospholipids / Q000097:blood*
D000900:Anti-Bacterial Agents; D005227:Fatty Acids; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D010743:Phospholipids; D000001:Calcimycin; D004533:Egtazic Acid; D002118:Calcium