Myxedematous madness without myxedema. Selective defect of TSH release on TRF loading in a young woman with a history of severe depressive illness cured with thryoid hormone replacement therapy.
A young woman, whose psychiatric history covered 16 years, has been treated several times as in-patient for psychotic depression, which were finally cured with thyroid replacement therapy. Recent reports of the connection between depression and disturbances in the hypothalamic-pituitary-thyroid axis are discussed. The authors question the suggestion that selective pituitary insufficiency and a defect in TSH release on TRF loading are rare phenomena.
D000293:Adolescent; D000328:Adult; D003863:Depression / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D007018:Hypopituitarism / Q000150:complications*; D007099:Imipramine / Q000627:therapeutic use; D007455:Iodine / Q000097:blood; D010902:Pituitary Gland / Q000378:metabolism*; D010903:Pituitary Gland, Anterior / Q000378:metabolism*; D011485:Protein Binding; D013972:Thyrotropin / Q000097:blood / Q000378:metabolism*; D013973:Thyrotropin-Releasing Hormone; D014284:Triiodothyronine / Q000627:therapeutic use*
D014284:Triiodothyronine; D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin; D007455:Iodine; D007099:Imipramine