[Action potential changes induced by a polyflavane on normal or hypoxic guinea pig myocardial strips].
On normal isolated or stimulated Guinea-Pig myocardial strips, a polyflavane extracted from Poterium spinosum (Rosaceae) increased the duration of the action potential plateau phase. Such a modification was also elicited on hypoxic strips; in this case it did not depend on the glucose concentration in the medium; it could be related to an effect on the slow calcium-sodium channel.
D000200:Action Potentials / Q000187:drug effects*; D000818:Animals; D005419:Flavonoids / Q000494:pharmacology*; D005947:Glucose / Q000494:pharmacology; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects / Q000502:physiology*; D000860:Hypoxia / Q000503:physiopathology*; D066298:In Vitro Techniques
D005419:Flavonoids; D005947:Glucose
Modifications du potentiel d'action provoquées par un polyflavane sur le lambeau myocardique normal ou hypoxié de cobaye