[Ampicillin concentrations in serum and bile after oral administration of ampicillin and pivampicillin].
The concentrations of active agent were determined in the bile and serum after oral administration of ampicillin and pivampicillin to 12 patients 7-9 days after surgical revision of the common bile duct.  Orally, pivampicillin is more rapidly absorbed, maxima of active agent and the mean serum concentrations are higher compared with ampicillin.  The rate of absorption and serum concentrations after giving ampicillin and pivampicillin depend on the type of diet.  Pivampicillin produces higher concentrations of active agent in the bile of the common bile duct more rapidly than ampicillin.  The mean concentration of active substance in the bile is distinctly above the serum concentrations.
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000667:Ampicillin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000032:analysis / Q000097:blood / Q000378:metabolism*; D001646:Bile / Q000032:analysis; D004032:Diet; D004952:Esters; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014631:Valerates / Q000378:metabolism
D004952:Esters; D014631:Valerates; D000667:Ampicillin
Ampicillin-Konzentrationen in Serum und Galle nach oraler Gabe von Ampicillin und Pivampicillin