Interaction of sudoxicam and aspirin in animals and man.
In rats, both the plasma concentrations and the anti-inflammatory activity of sudoxicam are depressed by concurrent administration of aspirin, being similar to that reported for other nonsteroidal agents, whereas, in man and monkey, plasma concentrations of sudoxicam are not affected by concurrent administration of aspirin. In this respect sudoxicam differs from such other nonsteroidal anti-inflammatory agents as indomethacin and naproxen.
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D001241:Aspirin / Q000494:pharmacology*; D003864:Depression, Chemical; D004347:Drug Interactions; D004487:Edema / Q000188:drug therapy; D006207:Half-Life; D000882:Haplorhini; D006801:Humans; D007700:Kinetics; D008253:Macaca mulatta; D008297:Male; D051381:Rats; D013045:Species Specificity; D013843:Thiazines / Q000097:blood / Q000494:pharmacology* / Q000627:therapeutic use
D013843:Thiazines; D001241:Aspirin