Subacute sclerosing panencephalitis: experimental infection in primates.
Measles virus isolated from the brain of a 12-year-old boy with subacute sclerosing panencephalitis caused a chronic, progressive encephalitis in experimentally infected rhesus monkeys. The infection was eventually fatal in spite of pre-existing measles immunity and a vigorous secondary antibody response in serum and cerebrospinal fluid of the infected animals. The findings provide a basis for studies into the pathogenesis and possible treatment of the human disease.
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis / Q000134:cerebrospinal fluid; D000956:Antigens, Viral / Q000032:analysis; D001812:Blood-Brain Barrier; D001921:Brain / Q000276:immunology / Q000473:pathology; D006224:Cricetinae; D004195:Disease Models, Animal; D007156:Immunologic Memory; D008253:Macaca mulatta; D008459:Measles virus / Q000276:immunology; D013344:Subacute Sclerosing Panencephalitis / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D014776:Virus Cultivation
D000914:Antibodies, Viral; D000956:Antigens, Viral