Antiviral drugs and corneal wound healing.
Using a previously described well standardized wound strength model, the fate of different antiviral drugs from corneal wound healing was evaluated. While 1.0 per cent trifluorothymidine and 0.1 per cent cytosine arabinoside were found to cause a significant delay of central corneal wounds, 0.1 per cent idoxuridine (IDU), three drops four times a day for twelve days, resulted in no significant delay in the healing strength of central corneal wounds.
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D003315:Cornea / Q000187:drug effects; D065306:Corneal Injuries; D003561:Cytarabine / Q000494:pharmacology; D007065:Idoxuridine / Q000494:pharmacology; D008954:Models, Biological; D011817:Rabbits; D014271:Trifluridine / Q000494:pharmacology; D014945:Wound Healing / Q000187:drug effects*
D000998:Antiviral Agents; D003561:Cytarabine; D007065:Idoxuridine; D014271:Trifluridine