title: Cross tolerance to antinociception elicited by intracerebroventricular administration of mescaline and morphine to rabbits, and EEG correlates.
abstract: Tolerance and cross tolerance to the antinociceptive effect of equipotent doses of morphine (10 mug/kg) and mescaline (100 mug/kg) are shown in the rabbit after their repeated intracerebroventricular administration. The recording of the electrical activity of different brain areas indicates that a partial tolerance also develops to the EEG effects in animals undergoing chronic treatment with mescaline. The comparison of certain of the mescaline-induced effects with those of morphine suggests that some biochemical and neural patterns are common to the 2 drugs.
mesh_terms: D000698:Analgesia; D000818:Animals; D001921:Brain / Q000187:drug effects*; D003429:Cross Reactions; D004361:Drug Tolerance; D004569:Electroencephalography; D007276:Injections, Intraventricular; D008297:Male; D008635:Mescaline / Q000494:pharmacology*; D009020:Morphine / Q000494:pharmacology*; D011817:Rabbits
chemical_list: D009020:Morphine; D008635:Mescaline