Primary structure of cholera toxin beta-chain: a glycoprotein hormone analog?
The completed sequence of the beta-chain of cholera toxin (103 amino acid residues) was compared to the beta-chains of chorionic gonadotropin, thyrotropin, luteinizing, and follicle stimulating hormones. The overall chemical similarity of the toxin beta-chain to the hormones was not statistically different from random; however, a comparison of the first 40 residues of the toxin beta-chain to the glycoprotein hormones revealed a segment of the hormones which was significantly chemically similar. The probability was less than .003 that the similarity was due to chance.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D005075:Biological Evolution; D002417:Cattle; D006063:Chorionic Gonadotropin; D004768:Enterotoxins / Q000378:metabolism; D005640:Follicle Stimulating Hormone; D006023:Glycoproteins; D006801:Humans; D007986:Luteinizing Hormone; D010447:Peptide Hydrolases; D013329:Structure-Activity Relationship; D013972:Thyrotropin; D014734:Vibrio cholerae
D006063:Chorionic Gonadotropin; D004768:Enterotoxins; D006023:Glycoproteins; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin; D010447:Peptide Hydrolases; D000262:Adenylyl Cyclases