Effects of long-term corn consumption on brain serotonin and the response to electric shock.
Rats fed tryptophan-poor corn diets have reduced levels of brain serotonin and show increased responsiveness to electric shock. This diet-induced hyperalgesia can be reversed by feeding the animals diets with adequate amounts of tryptophan, or by systemic injections of the amino acid.
D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology; D004195:Disease Models, Animal; D008297:Male; D010146:Pain / Q000503:physiopathology*; D011502:Protein-Energy Malnutrition / Q000378:metabolism / Q000503:physiopathology; D051381:Rats; D012701:Serotonin / Q000378:metabolism* / Q000502:physiology; D014364:Tryptophan / Q000172:deficiency* / Q000627:therapeutic use
D012701:Serotonin; D014364:Tryptophan