Transport of D- and L-tryptophan in Bacillus megaterium by an inducible permease.
Tryptophan-grown cells of Bacillus megaterium ATCC 19213 contain a permease system that transports both D- and L-tryptophan and is inhibited by sodium azide. Arginine-grown cells contain little tryptophan permease activity, suggesting that the system is inducible. Arginine represses the tryptophan permease as well as the transport system for leucine and phenylalanine. Kynurenine was a more effective inducer of the tryptophan transport system than either D- or L-tryptophan.
D001120:Arginine / Q000378:metabolism; D001386:Azides / Q000494:pharmacology; D001410:Bacillus megaterium / Q000201:enzymology / Q000378:metabolism*; D001693:Biological Transport, Active; D002250:Carbon Radioisotopes; D002701:Chloramphenicol / Q000494:pharmacology; D004790:Enzyme Induction; D004794:Enzyme Repression; D007700:Kinetics; D007737:Kynurenine / Q000494:pharmacology; D007930:Leucine / Q000378:metabolism; D026901:Membrane Transport Proteins / Q000378:metabolism*; D010649:Phenylalanine / Q000378:metabolism; D013237:Stereoisomerism; D014364:Tryptophan / Q000378:metabolism*
D001386:Azides; D002250:Carbon Radioisotopes; D026901:Membrane Transport Proteins; D007737:Kynurenine; D010649:Phenylalanine; D002701:Chloramphenicol; D014364:Tryptophan; D001120:Arginine; D007930:Leucine