[Effect of organophosphorus compounds on esterases in rat intestine- a comparing histochemical and biochemical investigation (author's transl)].
The effect of 5 organophosphorus pesticids on the rat intestine and serum was investigated with histochemical and biochemical methods. The results of both methods were corresponding in nonspecific esterases of rat intestine. They differ in cholinesterases. Furthermore the effect on serum esterases of rat and man was investigated. With few exceptions the results corresponded too. We concluded, that the intestine is a suitable object for testing antiesterase action histochemically. General statements about total toxicity of a pesticid, however, are not possible.
D000818:Animals; D002800:Cholinesterase Inhibitors; D002802:Cholinesterases / Q000097:blood; D004117:Dimethoate / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004950:Esterases / Q000037:antagonists & inhibitors* / Q000097:blood; D006801:Humans; D007421:Intestine, Small / Q000201:enzymology*; D007928:Lethal Dose 50; D008297:Male; D008743:Methyl Parathion / Q000494:pharmacology; D009943:Organophosphorus Compounds / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D014236:Trichlorfon / Q000494:pharmacology
D002800:Cholinesterase Inhibitors; D009943:Organophosphorus Compounds; D008743:Methyl Parathion; D014236:Trichlorfon; D004950:Esterases; D002802:Cholinesterases; D004117:Dimethoate
Die Wirkung phosphororganischer Verbindungen auf die Darmesterasen der Ratte - ein vergleichende histo- und biochemische Untersuchung