[Role of the central and peripheral cholinoreceptors in the processes of short-term memory].
Short-term memory with blocked cholinoreceptors was studied by the method of deferred reactions in the choice of one of 3--4 feeding troughs in tests staged on 5 dogs and 5 cats. Disturbances of short-term memory were caused by blocking of central m-cholinoreceptors with benactizyne (0.1--0.4 mg/kg). On abolishing peripheral symptoms arising under the effect of chlorpromazine with carbocholine (0.001 mg/kg) the short-term memory disturbances go on persisting. Blocking of peripheral m-cholino-receptors with lachesine (0.01--0.1 mg/kg) does not have any significant effect on the short-term memory. Under the blocking action of pediphen (0.5--2 mg/kg) on the cerebral n-cholinoreceptors the short-term memory improves with reduced memorization capacity.
D000818:Animals; D001535:Benactyzine / Q000494:pharmacology; D001561:Benzilates / Q000494:pharmacology; D002217:Carbachol / Q000494:pharmacology; D002415:Cats; D003214:Conditioning, Classical / Q000187:drug effects; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D008570:Memory, Short-Term / Q000187:drug effects / Q000502:physiology*; D009407:Nerve Block; D010276:Parasympatholytics / Q000494:pharmacology; D010404:Penicillin V / Q000494:pharmacology; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology; D011950:Receptors, Cholinergic / Q000187:drug effects; D013997:Time Factors
D001561:Benzilates; D010276:Parasympatholytics; D000644:Quaternary Ammonium Compounds; D011950:Receptors, Cholinergic; D001535:Benactyzine; D002217:Carbachol; D010404:Penicillin V
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