[Cardiotoxicity in rats of purified gamma toxin isolated from venom of Naja nigricollis and of toxins extracted from scorpion venom].
In vivo, atropine or tetrodotoxin prevent arrhytmias which are due to acetylcholine released by the scorpion's venom. On the contrary, atropine is ineffective against cardiotoxicity of the purified gamma toxin and tetrodotoxin aggravates its effects. These findings allow us to postulate the mechanism of action which differs in these two toxin groups.
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D001285:Atropine / Q000494:pharmacology; D004562:Electrocardiography; D006321:Heart / Q000187:drug effects*; D006614:Hindlimb; D009119:Muscle Contraction / Q000187:drug effects; D051381:Rats; D012605:Scorpions; D012910:Snake Venoms / Q000494:pharmacology; D013779:Tetrodotoxin / Q000494:pharmacology; D014118:Toxins, Biological / Q000494:pharmacology*; D014688:Venoms / Q000494:pharmacology*
D012910:Snake Venoms; D014118:Toxins, Biological; D014688:Venoms; D013779:Tetrodotoxin; D001285:Atropine
Cardiotoxicité chez le rat de la toxine gamma purifiée, isolée du venin de Naja nigricollis et des toxines extraites du venin de scorpion