An experimental model for peripheral nerve tumours in monkeys.
The induction of tumours of the peripheral nerves in Macaca mulatta has been accomplished by injections of the carcinogen methylnitrosourea in combination with organospecific immunization with antigens from the homologous tissue (sciatic nerve). The histology and biological peculiarities of the tumours are similar to those seen in man.
D000818:Animals; D000941:Antigens / Q000008:administration & dosage; D000882:Haplorhini; D008251:Macaca; D008253:Macaca mulatta; D008770:Methylnitrosourea; D008992:Monkey Diseases / Q000209:etiology* / Q000473:pathology; D009442:Neurilemmoma / Q000209:etiology* / Q000473:pathology; D010524:Peripheral Nervous System Neoplasms / Q000209:etiology* / Q000473:pathology; D012584:Sciatic Nerve / Q000276:immunology / Q000473:pathology
D000941:Antigens; D008770:Methylnitrosourea