title: [Mechanism of action of gliquidone (author's transl)].
abstract: A study of 13 metabolically normal persons, 12 patients with asymptomatic or latent diabetes and 11 with manifest diabetes showed that 30 mg gliquidone orally prevents or delays the blood sugar rise during repeated small carbohydrate meals with simultaneous stimulation of insulin secretion. This effect was less marked in the normal and asymptomatic or latent diabetic subjects than after glibenclamide 5 mg, while there was no difference between the two drugs in those with manifest diabetes.
mesh_terms: D000284:Administration, Oral; D001786:Blood Glucose / Q000032:analysis; D003920:Diabetes Mellitus / Q000188:drug therapy; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005905:Glyburide / Q000008:administration & dosage / Q000627:therapeutic use; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D007328:Insulin / Q000097:blood; D011236:Prediabetic State / Q000188:drug therapy; D013453:Sulfonylurea Compounds / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007004:Hypoglycemic Agents; D007328:Insulin; D013453:Sulfonylurea Compounds; C010969:gliquidone; D005905:Glyburide
vernacular_title: Untersuchungen zum Wirkungsmechanismus von Gliquidon. Vergleichende Untersuchungen zwischen Gliquidon und Glibenclamid nach oraler Gabe während kontinuierlicher Kohlenhydratzufuhr