[The effect of exogenous catecholamines on the cardiac rhythm and thermoregulation of hibernating hedgehogs (Erinaceus europaeus L.)].
No disturbance was seen either in cardiac rhythm or in temperature of hibernating Hedgehog (Erinaceus europaeus L.) after an isotonic saline injection, with the help of a permanent aortic indwelling catheter. Partial or complete arousal was quickly obtained after increasing doses of norepinephrine (NE), while dihydroxyphenylalanine (L-Dopa), its natural precursor, induced the same effects more slowly. To differentiate the peripheral and central effects of L-Dopa, we used a pretreatment of Ro 4-4602, an inhibitor of the peripheral decarboxylation of L-Dopa; under these conditions we could not induce arousal in the hibernating animals. The arousals observed after NE and L-Dopa administration are suggested to be dependent upon a peripheral action of exogenous catecholamines, copying a natural mobilization of catecholamines reserves.
D000818:Animals; D001545:Benserazide / Q000494:pharmacology; D001833:Body Temperature Regulation / Q000187:drug effects*; D002262:Carboxy-Lyases / Q000037:antagonists & inhibitors; D002395:Catecholamines / Q000494:pharmacology*; D004567:Electrodes, Implanted; D006339:Heart Rate / Q000187:drug effects*; D006605:Hibernation / Q000187:drug effects*; D007980:Levodopa / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology
D002395:Catecholamines; D007980:Levodopa; D001545:Benserazide; D002262:Carboxy-Lyases; D009638:Norepinephrine
Effets des catécholamines d'origine exogène sur le rythme cardiaque et la thermorégulation du Hérisson (Erinaceus europaeus L.) en hibernation