[Variations in circulating bradykinin and its precursor during treatment with ethanol and disulfiram in the dog].
Blood variations of bradykininogen and bradykinin have been measured in the Dog after single or combined treatments with ethanol and disulfiram. Ethanol only induces hyperbradykinnemia and chronic disulfiram decreases plasmatic level of bradykinnogen without modifying bradykinn. During associated treatment disulfiram-ethanol, physiological disturbances are observed in bradykinin formation; these disturbances can explain partly vasomotor reaction following treatments.
D000818:Animals; D001920:Bradykinin / Q000097:blood*; D003864:Depression, Chemical; D004221:Disulfiram / Q000494:pharmacology*; D004285:Dogs; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology*; D008297:Male
D000431:Ethanol; D001920:Bradykinin; D004221:Disulfiram
Variations de la bradykinne circulante et de son précurseur au cours de traitements à l'éthanol et au disulfirame chez le chien