[Study of TRH in the postganglionic sypnasis of the isolated human vas deferens].
Cummulative dose-response curves to l-noradrenaline and in presence of different concentrations of TRH (10(-3), 10(-4), 10(-5), 10(-6), 10(-7), and 10(-8) M) were investigated. 25 segments of vas deferens (escrotal tract) were obtained from different surgical patients of urological disorders. At the lower concentration (greater than 10(-7) M), we can not appreciate any influence of TRH on the l-noradrenaline response. Nevertheless there was a reduction of response to l-noradrenaline, with displacement of the curves to the right side, for the high concentrations, and a proportional ratio to the concentration to TRH.
D000236:Adenoma / Q000378:metabolism; D000368:Aged; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000494:pharmacology; D011471:Prostatic Neoplasms / Q000378:metabolism; D013268:Stimulation, Chemical; D013973:Thyrotropin-Releasing Hormone / Q000037:antagonists & inhibitors / Q000378:metabolism*; D001749:Urinary Bladder Neoplasms / Q000378:metabolism; D014649:Vas Deferens / Q000378:metabolism*
D013973:Thyrotropin-Releasing Hormone; D009638:Norepinephrine
Estudio de la T.R.H. en la sinápsis postgangliónica del conducto deferente humano aislado