title: Immunoglobulins on the surface of blast cells in human acute leukemia.
abstract: By means of the direct fluorescent antibody technique it was shown that malignant cells in acute lymphoblastic leukemia do not, as a rule, bear immunoglobulins on the cell surgace (43 of 45 cases). During complete remission the number of Ig-positive cells corresponds to the number of Ig-positive cells in normal lymphocyte populations. During incomplete remission as well as during incomplete remission as well as during intensive chemotherapy, the lymphocyte-like cells are evidently malignant, since they do not contain a normal number of Ig-positive lymphocytes. In acute myeloblastic leukemia (AML) and acute myelomonoblastic leukemia (AMML), lymphocytes distribute normally according to the number of Ig-positive and Ig-negative in 34 of 38 cases. AMML blast cells were Ig-positive in nine of ten cases. The data are discussed in the light of current concepts about the presence of a common precursor cell of granulocytes and monocytes.
mesh_terms: D000042:Absorption; D000328:Adult; D000818:Animals; D000888:Antibodies, Anti-Idiotypic; D002648:Child; D002850:Chromatography, Gel; D005455:Fluorescent Antibody Technique; D006801:Humans; D007106:Immune Sera; D007143:Immunoglobulin Heavy Chains; D007945:Leukemia, Lymphoid / Q000276:immunology*; D007948:Leukemia, Monocytic, Acute / Q000276:immunology*; D015470:Leukemia, Myeloid, Acute / Q000276:immunology*; D008099:Liver / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D009360:Neoplastic Cells, Circulating / Q000276:immunology*; D011817:Rabbits / Q000276:immunology; D011947:Receptors, Antigen, B-Cell / Q000032:analysis*; D012008:Recurrence; D012075:Remission, Spontaneous
chemical_list: D000888:Antibodies, Anti-Idiotypic; D007106:Immune Sera; D007143:Immunoglobulin Heavy Chains; D011947:Receptors, Antigen, B-Cell