[The influence of neuroleptics on the emotional anger reaction in animals].
In experimental observations the reaction of anger in cats was tested under the effects of psychotropic drugs. They were inhibited by chlopromazine and trifluoperazine. An even stronger effect on the emotional and in addition on the reaction of aggression is produced by haloperidol. By electrical and chemical stimulation of the anterior section of the hypothalamus and the central substantia grisea the evoked fit of emotion, as regards the vegetative and motor manifestations is repressed by all three preparations; but not as regards the specific components of the anger reaction, like growling and spitting. In further experiments chlorpromazine, trifluoperazine and haloperidol were injected into the nucleus amygdalae and in the nucleus caudatus. This resulted in a pronounced tropism in the amygdaloid nucleus, and a lesser tropism in the nucleus caudatus with the neuroleptica of the phenothiazine type. Haloperidol, on the other hand, did not effect the activity of the nucleus amygdalae and creates an obvious tropism in the nucleus caudatus.
D000374:Aggression / Q000187:drug effects; D000786:Anger / Q000187:drug effects*; D000818:Animals; D002415:Cats; D002746:Chlorpromazine / Q000494:pharmacology; D004569:Electroencephalography; D006220:Haloperidol / Q000494:pharmacology; D006801:Humans; D014149:Tranquilizing Agents / Q000494:pharmacology*; D014268:Trifluoperazine / Q000494:pharmacology
D014149:Tranquilizing Agents; D014268:Trifluoperazine; D006220:Haloperidol; D002746:Chlorpromazine
Der Einfluss von Neuroleptika auf die emotionale Wutreaktion bei Tieren.