Prostaglandin synthetase activity in kidney medulla during the development of experimental hypertension in the rat.
The activity of the Pg-E2-synthetase in the rat renal medulla was observed for a period of 27 days during the development of a hypertension by clamping of the renal artery; an increased activity of Pg-E2-synthetase with a peak on the 18th day was observed in the kidneys of the 2-kidney model (2-KM=stenosing of the left arteria renalis) and the 1-kidney model (1-KM=stenosing of the left arteria renalis and additional nephrectomy of the right kidney). The initial values of the enzyme activities were reached again on the 21st (1-KM) resp. 24th (2-KM) day post operationem.
D000818:Animals; D006977:Hypertension, Renal / Q000201:enzymology*; D007668:Kidney / Q000201:enzymology*; D007679:Kidney Medulla / Q000201:enzymology*; D008026:Ligation; D008297:Male; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D009392:Nephrectomy; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*; D051381:Rats; D012077:Renal Artery
D006899:Mixed Function Oxygenases; D011451:Prostaglandin-Endoperoxide Synthases