[Toxicity and virulence of different strains of meningococcus].
With the aid of a modified Dubos and Schaedleder's method a determination was made on albino mice of the toxicity of 49 strains of meningococcus. The greatest toxicity was possessed by strains isolated from the cerebrospinal fluid of patients with cerebrospinal meningitis; standard strains were less toxic and strains isolated from healthy carriers were nontoxic. The living and the heated cultures of meningococci produced the same toxic action which was apparently associated with the thermostable antigens of the cell. The virulence studied in 24 strains of meningococcus on a model of 9-day chick embryos failed to correlate with the toxic properties of the strains.
D000818:Animals; D002555:Cerebrospinal Fluid / Q000382:microbiology; D002642:Chick Embryo; D006801:Humans; D008585:Meningitis, Meningococcal / Q000382:microbiology; D051379:Mice; D009345:Neisseria meningitidis / Q000302:isolation & purification / Q000472:pathogenicity*; D014774:Virulence
Toksichnost' i virulentnost' razlichnykh shtammov meningokokka