Pulmonary cell response patterns after exposure to airborne bacteria.
The free lung cells obtained with a lavage technique were studied in guinea-pigs exposed to an aerosol of E.coli, K. pneumoniae or B.subtilis. An increase in the number of polymorphonuclear leucocytes was found 5-48 hours after exposure to E.coli and B.subtilis. The clearance of a mixture of viable and radioactively labelled E.coli was studied in animals with a naturally present or artificially induced high leucocyte level in the lungs. It was found that animals with the higher leucocyte number cleared the inhaled bacteria faster.
D000336:Aerosols; D000818:Animals; D001412:Bacillus subtilis; D001419:Bacteria; D002452:Cell Count; D002478:Cells, Cultured; D004926:Escherichia coli; D006168:Guinea Pigs; D007711:Klebsiella pneumoniae; D007958:Leukocyte Count; D007962:Leukocytes; D008168:Lung / Q000166:cytology* / Q000276:immunology / Q000382:microbiology; D008264:Macrophages; D008297:Male; D009504:Neutrophils; D013997:Time Factors
D000336:Aerosols