[BCG potentiates the immunodepression induced by cyclophosphamide].
Compared to the effect of CPM alone, the survival of allogeneic C3H skin grafts on Fl (DBA/2 X C57Bl/6) recipients is considerably enhanced when the recipient is given BCG (1 mg/mouse) 14 days before the graft and CPM (80 or 134 mg/kg) one day after the graft. While other mechanisms cannot be entirely excluded, it is possible that BCG stimulates the lymphocytes to enter the cell cycle, which makes them more sensitive to CPM, a cycle-dependent agent.
D000818:Animals; D001500:BCG Vaccine; D003520:Cyclophosphamide / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006084:Graft Rejection; D007165:Immunosuppression Therapy; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009163:Mycobacterium bovis / Q000276:immunology*; D016038:Skin Transplantation; D013997:Time Factors; D014181:Transplantation Immunology; D014184:Transplantation, Homologous
D001500:BCG Vaccine; D003520:Cyclophosphamide
Potentialisation par administration de BCG d'une immunodépression induite par la cyclophosphamide. Applications aux transplantations