[Acetylcholinesterase activity of neuroblastoma and different glial cells in co-culture].
When mouse neuroblasts (clonal line M 1) and hamster astroblasts (clonal line NN) were co-cultured, the originally low activity of acetylcholinesterase of both lines was drastically increased. After 2 months the neuroblastoma M 1 cells were reisolated from the co-culture and were found to contain 10 times higher activity of acetylcholinesterase than the original M 1 cells. This increased activity was maintained over more than 14 subcultures. In contrast, co-cultivation of neuroblastoma M 1 cells with rat astrocytoma cells (clonal line C 6) resulted in a decrease of actylcholinesterase activity compared to either original cell line.
D000110:Acetylcholinesterase / Q000032:analysis*; D000818:Animals; D001253:Astrocytes / Q000201:enzymology*; D001254:Astrocytoma / Q000201:enzymology*; D002462:Cell Membrane / Q000201:enzymology; D002478:Cells, Cultured; D006224:Cricetinae; D004790:Enzyme Induction; D004794:Enzyme Repression; D051379:Mice; D009447:Neuroblastoma / Q000201:enzymology*; D009457:Neuroglia / Q000201:enzymology*; D051381:Rats
D000110:Acetylcholinesterase
Activité acétylcholinestérasique des celludes de neuroblastome et des cellules gliales en coculture