title: [Influence of actinomycin D on Xenopus heart differentiation in organ culture].
abstract: The cardiac differentiation of the African clawed Toad was studied in culture with Actinomycin D. In terms of drug amounts used and the duration of treatment, a limit coefficient was defined, beyond which the heart did not again differentiate. The results were interpreted by the existence of a threshold in the inhibition of ARNr synthesis, whose total turn-over seemed to be 24 hours.
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects*; D003609:Dactinomycin / Q000494:pharmacology*; D006321:Heart / Q000196:embryology*; D009924:Organ Culture Techniques; D012335:RNA, Ribosomal / Q000502:physiology; D014981:Xenopus / Q000196:embryology*
chemical_list: D012335:RNA, Ribosomal; D003609:Dactinomycin
vernacular_title: Influence de l'actinomycine D sur la differenciation cardiaque du xénope en culture organotypique