title: Cytogenetic analysis of oral and cutaneous squamous cell carcinomas in the rat.
abstract: Chromosomes of induced carcinomas in the oral mucosa and epidermis of rats were studied in vitro. The tumours were induced by repeated applications of one of two carcinogens: the fat-soluble 7,12-dimethylbenz (a) anthracene (DMBA) or the water-soluble 4-nitrochinoline N-oxide (4NQO). Non-random chromosomal patterns, different for each carcinogen, were revealed, irrespective of the location of the tumour. The DMBA-induced carcinomas showed the same karyotypic deviations as those in leukemias and sarcomas induced in the rat by the same carcinogen. The 4NQO-induced carcinomas displayed chromosome features similar to those previously observed in embryonic rat tissue subjected to malignant transformation by the same agent.
mesh_terms: D015112:4-Nitroquinoline-1-oxide; D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced; D002471:Cell Transformation, Neoplastic; D002869:Chromosome Aberrations; D046508:Culture Techniques; D007621:Karyotyping; D009062:Mouth Neoplasms; D051381:Rats; D012878:Skin Neoplasms
chemical_list: D015112:4-Nitroquinoline-1-oxide; D015127:9,10-Dimethyl-1,2-benzanthracene