Inhibition of prostaglandin synthetase by tolmetin (Tolectin, McN-2559), a new non-steroidal anti-inflammatory agent.
D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D002417:Cattle; D016861:Cyclooxygenase Inhibitors; D007213:Indomethacin / Q000494:pharmacology; D007700:Kinetics; D008297:Male; D008861:Microsomes / Q000201:enzymology; D006899:Mixed Function Oxygenases / Q000037:antagonists & inhibitors*; D011458:Prostaglandins E / Q000096:biosynthesis; D011758:Pyrroles / Q000494:pharmacology*; D012669:Seminal Vesicles / Q000201:enzymology; D013329:Structure-Activity Relationship; D014046:Tolmetin / Q000494:pharmacology*
D016861:Cyclooxygenase Inhibitors; D011458:Prostaglandins E; D011758:Pyrroles; D014046:Tolmetin; D006899:Mixed Function Oxygenases; D001241:Aspirin; D007213:Indomethacin