Chemotaxis of rabbit macrophages in vitro: inhibition by drugs.
Chemotaxis of rabbit macrophages was inhibited by phenylbutazone and sodium salicylate, but not by other antiinflammatory agents. Other inhibitory compounds were colchicine, vincristine, PHA, Con A, iodoacetic acid, cytochalasin B, and EDTA. Some of these in vitro results contrast apparently with in vivo effects.
D000818:Animals; D002633:Chemotaxis / Q000187:drug effects*; D003078:Colchicine / Q000494:pharmacology; D003571:Cytochalasin B / Q000494:pharmacology; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D004492:Edetic Acid / Q000494:pharmacology; D066298:In Vitro Techniques; D007461:Iodoacetates / Q000494:pharmacology; D037102:Lectins / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000502:physiology*; D010653:Phenylbutazone / Q000494:pharmacology*; D011136:Polysorbates / Q000494:pharmacology; D011817:Rabbits; D012459:Salicylates / Q000494:pharmacology*; D014750:Vincristine / Q000494:pharmacology
D007461:Iodoacetates; D037102:Lectins; D011136:Polysorbates; D012459:Salicylates; D003571:Cytochalasin B; D014750:Vincristine; D004492:Edetic Acid; D010653:Phenylbutazone; D003078:Colchicine; D004121:Dimethyl Sulfoxide