title: Measurement of stroke volume from pulmonary artery pressure record in man.
abstract: Stroke volume was determined from the pulmonary artery pressure record by application of the pulse contour method. Pulmonary artery pressure records were obtained in 17 patients using a high fidelity catheter-tip pressure transducer and simultaneous measurements of cardiac output were obtained from indicator dilution curves. The formula used was SV = KP sa (i plus T s/Td) where Psa is the planimetered area beneath the systolic portion of the pulmonary artery pressure curve. Ts and Td are the durations of systole and diastole, and K is a constant. Stroke volume was altered by isometric handgrip exercise and/or pharmacological agents in 15 patients. Serial measurementswere made in 2 patients in acute pulmonary oedema after myocardial infarction. Comparison of a wide range of values of stroke volume by the pulse contour method with those obtained from dye dilution curves showed a good correlation (r plus 0.97, P smaller than 0.001) regression line y = 1.01 times - 0.47. Measurement of stroke volume from the pulmonary artery pressure contour is a technique of potential value in serial haemodynamic monitoring.
mesh_terms: D001794:Blood Pressure; D006328:Cardiac Catheterization; D002302:Cardiac Output / Q000187:drug effects; D002312:Cardiomyopathy, Hypertrophic / Q000503:physiopathology; D002395:Catecholamines / Q000494:pharmacology; D003327:Coronary Disease / Q000503:physiopathology; D004395:Dye Dilution Technique; D004562:Electrocardiography; D005260:Female; D006333:Heart Failure / Q000503:physiopathology; D006334:Heart Function Tests / Q000379:methods; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D008944:Mitral Valve Insufficiency / Q000503:physiopathology; D009203:Myocardial Infarction / Q000503:physiopathology; D005996:Nitroglycerin / Q000494:pharmacology; D010042:Ouabain / Q000494:pharmacology; D010627:Phenethylamines / Q000494:pharmacology; D010636:Phenols / Q000494:pharmacology; D011217:Practolol / Q000494:pharmacology; D011651:Pulmonary Artery / Q000502:physiology* / Q000503:physiopathology; D011674:Pulse
chemical_list: D002395:Catecholamines; D010627:Phenethylamines; D010636:Phenols; D010042:Ouabain; D005996:Nitroglycerin; D007545:Isoproterenol; D011217:Practolol