Adrenergic inhibition of cell proliferation in the buccal epithelium of rat.
Mitotic rates in the basal layer of cells in the buccal epithelium of rat were measured using a stathmokinetic technique. Adrenaline was found to inhibit cell proliferation in this tissue and the effect of adrenaline could be blocked by the beta-adrenergic antagonist propranolol but not by the alpha-adrenergic antagonist phentolamine nor by the specific beta2-adrenergic antagonist butoxamine. Cell proliferation in the buccal mucosa was also inhibited by terbutaline, a synthetic beta2-adrenergic agonist. The effect of terbutaline was not blocked by either butoxamine or by the specific beta1-adrenergic antagonist practolol.
D000818:Animals; D002078:Butoxamine / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects*; D002610:Cheek / Q000187:drug effects*; D004837:Epinephrine / Q000494:pharmacology*; D008297:Male; D008938:Mitosis / Q000187:drug effects; D009061:Mouth Mucosa / Q000187:drug effects*; D010646:Phentolamine / Q000494:pharmacology; D011217:Practolol / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects*; D013726:Terbutaline / Q000494:pharmacology
D011941:Receptors, Adrenergic; D002078:Butoxamine; D011433:Propranolol; D013726:Terbutaline; D011217:Practolol; D004837:Epinephrine; D010646:Phentolamine