title: Effects of a polychlorinated biphenyl (PCB) on sleeping times, plasma corticosteroids, and testicular activity of white-footed mice.
abstract: Forty adult male white-footed mice (Peromyscus leucopus) were divided into four equal groups and fed diets containing 0, 100, 200 or 400 p.p.m. of a polychlorinated biphenyl (PCB) for 2 weeks. PCB ingestion increased liver weights and reduced pentobarbital-induced sleeping times at all levels tested, indicating increased hepatic microsomal enzyme activity. Plasma corticoid levels, seminal vesicle weights and testicular spermatozoa numbers were reduced at the 400 p.p.m. level.
mesh_terms: D000305:Adrenal Cortex Hormones / Q000097:blood*; D000311:Adrenal Glands / Q000187:drug effects; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008297:Male; D051379:Mice; D008862:Microsomes, Liver / Q000201:enzymology*; D009929:Organ Size / Q000187:drug effects; D011078:Polychlorinated Biphenyls / Q000494:pharmacology*; D012890:Sleep / Q000187:drug effects*; D013045:Species Specificity; D013737:Testis / Q000187:drug effects*
chemical_list: D000305:Adrenal Cortex Hormones; D011078:Polychlorinated Biphenyls