title: Umbilical vein occlusion and transient acceleration of the fetal heart rate. Experimental observations in subhuman primates.
abstract: Transient acceleration of the fetal heart rate is commonly seen in the cardiotachometer tracing of the human fetus during labor. A likely cause appeared to be partial occlusion of the umbilical cord. On the basis of this hypothesis, fetal cardiovascular responses to partial occlusion of the umbilical cord or isolated intra-abdominal portion of umbilical vein were studied in near-term pregnant baboons and rhesus monkeys prior to and following sympathetic blockade with dibenzyline and propranolol. The responses were of two types. In the well-oxygenated fetus, partial occlusion resulted in transient acceleration of heart rate and a decrease in pulse pressure. This response was abolished with dibenzyline or propranolol. In the hypoxic fetus, partial occlusion resulted in either bradycardia and hypotension or hypotension with no alteration in heart rate. Thus, transient acceleration of the fetal heart rate can be explained on the basis of a sympathetic response to diminished venous return. It would appear to be an early sign of a potential cord complication. This response will not be seen if the fetus becomes asphyxiated and hypoxic.
mesh_terms: D000818:Animals; D001775:Blood Circulation / Q000187:drug effects; D001794:Blood Pressure; D003250:Constriction; D005260:Female; D005318:Fetal Heart / Q000187:drug effects / Q000502:physiology* / Q000503:physiopathology; D005311:Fetal Hypoxia / Q000503:physiopathology; D000882:Haplorhini; D006339:Heart Rate / Q000187:drug effects; D008253:Macaca mulatta; D010215:Papio; D010643:Phenoxybenzamine / Q000494:pharmacology; D011247:Pregnancy; D011433:Propranolol / Q000494:pharmacology; D014470:Umbilical Cord; D014471:Umbilical Veins
chemical_list: D010643:Phenoxybenzamine; D011433:Propranolol