Human thymus/leukemia-associated antigen in normal and leukemic cells.
A saline extractable human thymus/leukemia-associated antigen (HThy-L) has been detected in immunodiffusion using rabbit antisera raised to human thymus extracts. HThy-L was demonstrated in extracts of normal thymocytes, lymphocytes from E-rosetting T-cell lines and from the blast cells of patients with E-rosetting acute lymphoblastic leukemia. Extracts of leukemic cells from patients with acute myeloblastic leukemia and E-rosette-negative acute lymphoblastic leukemia contained significantly lower quantities of HThy-L. Only trace amounts of the antigen were detected in normal spleen tonsil, peripheral blood, bone marrow and PHA-induced lymphoblasts. HThy-L appears to be an antigen associated with the intrathymic differentiation of human T cells and a marker of leukemic cells in certain forms of acute leukemia.
D000951:Antigens, Neoplasm / Q000032:analysis; D001402:B-Lymphocytes / Q000276:immunology; D001853:Bone Marrow / Q000276:immunology; D002460:Cell Line; D006801:Humans; D005779:Immunodiffusion; D007938:Leukemia / Q000276:immunology*; D007945:Leukemia, Lymphoid / Q000276:immunology; D015470:Leukemia, Myeloid, Acute / Q000276:immunology; D014066:Palatine Tonsil / Q000276:immunology; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology*
D000951:Antigens, Neoplasm