title: [Growth inhibition by antibiotics and the production of resistance to them in a population of Nostoc linckia].
abstract: Increasing concentrations of penicillin and streptomycin inhibited the growth of the blue-green alga Nostoc linckia. Although the alga could build up resistance to higher concentrations of penicillin (1000 mcg/ml), it was very sensitive to streptomycin beyond a concentration of 0.02 mcg/ml. Two stable mutants, one resistant to 1000 mcg penicillin/ml and another to 0.02 mcg streptomycin/ml were isolated, of which the latter had lost its nitrogen fixing capacity. Drug resistance seems to be due to nuclear or gene mutation.
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000458:Cyanobacteria / Q000187:drug effects* / Q000254:growth & development; D004305:Dose-Response Relationship, Drug; D006128:Growth / Q000187:drug effects; D009154:Mutation / Q000187:drug effects; D009586:Nitrogen Fixation / Q000187:drug effects; D010400:Penicillin G / Q000494:pharmacology; D010403:Penicillin Resistance; D013307:Streptomycin / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D010400:Penicillin G; D013307:Streptomycin
vernacular_title: Ingibirovanie antibiotikami rosta i poluchenie ustoĭchivosti k nim v populiatsii Nostoc linckia