[Clinical possibilities of a method for the simultaneous determination of the GFR and the ERBF using a "cocktail" of 169 EDTA and 125I-hippuran].
The results are discussed obtained from 198 patients with the two most frequently met kidney diseases--chronic glomerulonephritis and pyelonephritis, with a total of 396 renal clearance tests. In 65.7 per cent of the patients with chronic glomerulonephritis decreased values of blomerular filtration (GF) and the renal flow effect (RFE) were established, with a parallel decrease in both clearances in 56.5 per cent and isolated disturbances of GF in 31.9 per cent and of RFE in 11.6 per cent. In the patients with chronic pyelonephritis a parallel decrease of GF AND RFE was found in 66.7 per cent and isolated disturbances of GF in 13.6 per cent and RFE--in 19.7 per cent. The high percentage of parallelly decreased GF and RFE reveals the sensitivity of the method in the diagnosis of early renal functional alterations while the application of only one of the clearances might not detect the existing alterations. The results from the carried out comparative investigations between the isotope clearances and isotope nephrography with 131I--hippuran are also reportentage of the depuration radioisotope tests as compared with ING in the detection of early renal functional laterations. Radiation risk is rendered to a minimum with the use of the "cocktail" of 169U-EDTA and 125I-hippuran.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002908:Chronic Disease; D004492:Edetic Acid; D005919:Glomerular Filtration Rate; D005921:Glomerulonephritis / Q000175:diagnosis; D006801:Humans; D007457:Iodine Radioisotopes; D007465:Iodohippuric Acid; D007668:Kidney / Q000098:blood supply*; D008875:Middle Aged; D011704:Pyelonephritis / Q000175:diagnosis; D011866:Radioisotope Renography / Q000379:methods*; D012039:Regional Blood Flow
D007457:Iodine Radioisotopes; D007465:Iodohippuric Acid; D004492:Edetic Acid
Kinichni vuzmozhnosti na metoda za ednovremenno opredeliane na GF i EBP s "kokteĭl" ot 169Uv-EDTA i 125I-khipuran