title: The inactivation of thyrotrophin releasing hormone by plasma in thyroid disease.
abstract: The inactivation of immunoreactive TRH in vitro by human plasma has been investigated. In a preliminary study, 2.5 ng TRH was destroyed by 50 mul plasma at a mean rate of 1.7%/min in eight subjects. The per cent inactivation of the same amount of TRH at three plasma dose levels was measured after 60 min in seventy unselected patients attending a thyroid clinic. There was no significant difference in the results obtained in those subsequently shown to be euthyroid (forty-three patients), hyperthyroid (eighteen patients) or hypothyroid (nine subjects).
mesh_terms: D001769:Blood; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood*; D007037:Hypothyroidism / Q000097:blood*; D066298:In Vitro Techniques; D011863:Radioimmunoassay; D013959:Thyroid Diseases / Q000097:blood*; D013973:Thyrotropin-Releasing Hormone / Q000097:blood* / Q000276:immunology; D013997:Time Factors
chemical_list: D013973:Thyrotropin-Releasing Hormone