Role of histamine in posttraumatic spinal cord hyperemia and the luxury perfusion syndrome.
The authors studied the effect of pretreatment of monkeys with antihistamines on hyperemia observed in the lateral funiculus of the spinal cord after severe experimental spinal cord trauma. After administration of Chlorpheniramine and Metiamide, the spinal cords were traumatized with a 600 gm-cm injury. Blood flow in the lateral funiculus at the injury site was then determined hourly for 6 hours. The blood flow at this site remained in the normal range at all times in all animals. Neither a hyperemia nor an ischemia could be demonstrated. This finding reaffirms the authors' previous observation that ischemia does not exist in the lateral funiculus after severe experimental spinal cord trauma, and explains the previous observation of hyperemia as a histamine-related phenomenon, easily blocked by the administration of Chlorpheniramine and Metiamide, potent antihistamines which together block both the H1 and H2 receptor sites.
D000818:Animals; D001794:Blood Pressure; D002744:Chlorpheniramine / Q000627:therapeutic use; D000882:Haplorhini; D006632:Histamine / Q000502:physiology*; D006940:Hyperemia / Q000209:etiology / Q000503:physiopathology* / Q000517:prevention & control; D008253:Macaca mulatta; D008785:Metiamide / Q000627:therapeutic use; D012039:Regional Blood Flow / Q000187:drug effects; D013116:Spinal Cord / Q000098:blood supply; D013119:Spinal Cord Injuries / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D013577:Syndrome
D008785:Metiamide; D002744:Chlorpheniramine; D006632:Histamine