Stimulation of human prolactin secretion by sulpiride.
Intramuscular injection of 100 mg of sulpiride significantly raised plasma human prolactin (hPRL) levels in all of 7 normal subjects examined. The mean (+SE) peak value was 78.0 +/- 16.6 ng/ml, which was observed 30 min after the injection. Daily administration of sulpiride (50 mg tid po) raised plasma hPRL levels in all 7 patients with peptic ulcer, with peak values obtained within 2 weeks. Lactation occurred in 2 of these patients. It is concluded that sulpiride stimulates hPRL secretion in man.
D000293:Adolescent; D000328:Adult; D002746:Chlorpromazine / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D011388:Prolactin / Q000097:blood*; D013268:Stimulation, Chemical; D013276:Stomach Ulcer / Q000097:blood / Q000188:drug therapy; D013469:Sulpiride / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology
D013973:Thyrotropin-Releasing Hormone; D013469:Sulpiride; D011388:Prolactin; D002746:Chlorpromazine