[Some data from studying and using aminoglycoside antibiotics in reconstructive surgery].
Effectiveness of antibacterial drugs from the group of aminoglycoside antibiotics,i.e. kanamycin, gentamycin and tobramycin with respect to the main causative agents of surgical infections, i.e. Staphylococcus, Coli bacteria, Proteus and Ps. aeruginosa was shown. The highest activity against Ps. aeruginosa was registered to tobramycin. The aminoglycoside antibiotics were satisfactorily absorbed after their intramuscular administration providing therapeutic levels of the antibiotics in the blood. For instance, administration of gentamycin in a dose of 80 mg and tobramycin in a dose of 50 mg 1-2 times a day provided the blood levels higher than the minimun inhibitory concentrations for most strains of gramnegative flora including Ps. aeruginosa. The use of the above drugs in theraphy and prophylaxis of infections caused by Ps. aeruginosa is expedient.
D000617:Aminoglycosides / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001682:Biological Availability; D002031:Bulgaria; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000187:drug effects; D005839:Gentamicins / Q000494:pharmacology; D006801:Humans; D007273:Injections, Intramuscular; D007612:Kanamycin / Q000494:pharmacology; D007700:Kinetics; D008826:Microbial Sensitivity Tests; D011182:Postoperative Care; D011183:Postoperative Complications / Q000188:drug therapy / Q000382:microbiology; D011511:Proteus / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013210:Staphylococcus / Q000187:drug effects; D014031:Tobramycin / Q000494:pharmacology; D014586:USSR
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D005839:Gentamicins; D007612:Kanamycin; D014031:Tobramycin
Nekotorye dannye izucheniia i primeneniia antibiotikovaminoglikozidov v rekonstruktivnoĭ khirurgii