Inhibition of allergic reactions by cromoglycate and by a new anti-allergic drug(10-chloro-1,4,6,9-tetrahydro-4,6-dioxopyrido(3,2-g)quinoline-2,8-dicarboxylic acid). II. Activity in primates against aerosolized Ascaris suum antigen.
Immediate type hypersensitivity to Ascaris antigen in rhesus reactor monkeys was used to assess the pharmacologic profile of Cromolyn Na and a new inhibitor of IgE-medited lung function changes. Cutaneous reactivity to Ascaris correlated poorly with a respiratory response to antigen. Two parameters used to measure lung function, respiratory rate increase and tidal volume decrease, were significantly altered by Cromolyn Na and compound A.
D000336:Aerosols; D000818:Animals; D000941:Antigens / Q000008:administration & dosage; D001200:Ascaris / Q000276:immunology*; D004205:Cromolyn Sodium / Q000627:therapeutic use*; D005260:Female; D000882:Haplorhini; D006969:Hypersensitivity, Immediate / Q000175:diagnosis; D007442:Intubation, Intratracheal; D008253:Macaca mulatta; D011728:Pyridones / Q000627:therapeutic use*; D011804:Quinolines / Q000627:therapeutic use*; D012129:Respiratory Function Tests; D012130:Respiratory Hypersensitivity / Q000175:diagnosis / Q000188:drug therapy*; D012882:Skin Tests; D013990:Tidal Volume
D000336:Aerosols; D000941:Antigens; D011728:Pyridones; D011804:Quinolines; D004205:Cromolyn Sodium