title: [DNA-intercalating compounds. Synthesis of several monomers and 1 dimer of phenanthridinium bearing aminoalkoylated chains].
abstract: Several monomeric phenanthridinium salts quaternarized in the 5 position by different aminoalkyl chains are prepared from ammoniac or diamines and 3,8-biscarbethoxyamnio (3-bromo)-5 propyl 6-phenyl phenanthridinium bromide I. The reaction between one of the monomeric salts and I leads, after deprotection of the amino-groups to the dimer: (4,7-diaza decamethylene) bis 5,5' (3,8-diamino-6 phenyl phenanthridinium) tetrachloride. All these compounds show the fluorescence properties of the phenanthridinium ring and exhibit DNA affinity constant higher than ethidium bromide.
mesh_terms: D000641:Ammonia; D001665:Binding Sites; D004247:DNA / Q000037:antagonists & inhibitors*; D003959:Diamines; D004996:Ethidium / Q000031:analogs & derivatives; D005453:Fluorescence; D008968:Molecular Conformation; D009690:Nucleic Acid Conformation; D010617:Phenanthridines / Q000138:chemical synthesis*; D011108:Polymers
chemical_list: D003959:Diamines; D010617:Phenanthridines; D011108:Polymers; D000641:Ammonia; D004247:DNA; D004996:Ethidium
vernacular_title: Composés d'intercalation de l'ADN. synthèse de quelques monomères et d'un dimère de phénanthridinium á chaînes aminoalcoylées