Preliminary observations on the effects on the organs of mice of administering some carbamate pesticides.
Two pesticides, Karbatox 75 and Unden, were used for the investigation, in daily doses of 20 mg per kg body weight, injected intraperitoneally during a period of 20 days. A comparatively low toxicity of these compounds for mice was ascertained. Among morphological changes were found: hypertrophy of the intestinal epithelium, a decrease in size of liver cells and a significant increase in number of Gomori-positive glia cells, as well as an increase in the volume of cell nuclei in the neurosecretory neurocytes of hypothalamus.
D000818:Animals; D012721:Carbaryl / Q000633:toxicity; D002467:Cell Nucleus / Q000187:drug effects; D002875:Chromosomes / Q000187:drug effects; D007031:Hypothalamus / Q000648:ultrastructure; D007306:Insecticides / Q000633:toxicity*; D007620:Karyometry; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009457:Neuroglia / Q000648:ultrastructure; D001074:Propoxur / Q000633:toxicity; D013154:Spleen / Q000648:ultrastructure; D013737:Testis / Q000648:ultrastructure
D007306:Insecticides; D001074:Propoxur; D012721:Carbaryl