title: [Antidotal effect of TMB-4 compos. Spofa in sheep intoxicated with O-ethyl S-(2-dimethylaminoethyl) methyl phosphonothioate].
abstract: A single application of a mixture of cholinolytic and reactivator of cholinesterase (TMB-4 compos. SPOFA) administered intravenously in the dose of 10.0 mg of trimedoxim per kg of live weight to sheep for 60 minutes after an intramuscular intoxication with O-ethyl S-(2-dimethylaminoethyl) methyl phosphonothioate (EDMM) in the dose of 0.00835 mg per kg of live weight (i.m. LD50, 2h) produces an immediate clinical effect. The reactivation of the erythrocytary acetyl cholinesterase (AChE, E.C.3.1.1.7.) examined in 15 minutes after the administration of the antidotal mixture is almost 100 p.c., the reactivation of the plasmatic butyryl cholin esterase (ChE, E.C.3.1.1.8.) approx. from 70 to 80 p. c. Restitution ad integrum occurred not later than in 14 days after the intoxication.
mesh_terms: D000818:Animals; D000931:Antidotes / Q000627:therapeutic use*; D002800:Cholinesterase Inhibitors; D002801:Cholinesterase Reactivators / Q000627:therapeutic use*; D009946:Organothiophosphorus Compounds / Q000506:poisoning*; D010091:Oximes / Q000627:therapeutic use*; D011041:Poisoning / Q000188:drug therapy / Q000662:veterinary*; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy*; D014289:Trimedoxime / Q000627:therapeutic use*
chemical_list: D000931:Antidotes; D002800:Cholinesterase Inhibitors; D002801:Cholinesterase Reactivators; D009946:Organothiophosphorus Compounds; D010091:Oximes; D014289:Trimedoxime
vernacular_title: Antidotní efekt TMB-4 compos. (Spofa) u ovcí intoxikovaných o-etyl S-(2-dimetylaminoetyl)metyl-fosfonotioátem