Local treatment of thrombophlebitis with essaven gel.
Essaven Gel contains aescin, heparin and essential phospholipids (EPL). It was administered locally in 15 patients suffering from thrombotic inflammation of tibial superficial veins. The effect of Essaven Gel on prostaglandin synthetase activity was also studied. In 12 patients a positive result was obtained in the form of anti-inflammatory action, diminution of pain, edema, excessive warmth and flushing. The anti-inflammatory action proceeds without any participation of prostaglandin synthetase.
D000287:Administration, Topical; D000328:Adult; D000893:Anti-Inflammatory Agents; D016861:Cyclooxygenase Inhibitors; D004338:Drug Combinations; D004928:Escin / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D005782:Gels; D006493:Heparin / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D006899:Mixed Function Oxygenases / Q000037:antagonists & inhibitors*; D010743:Phospholipids / Q000494:pharmacology / Q000627:therapeutic use*; D012503:Saponins / Q000627:therapeutic use*; D013924:Thrombophlebitis / Q000188:drug therapy*
D000893:Anti-Inflammatory Agents; D016861:Cyclooxygenase Inhibitors; D004338:Drug Combinations; D005782:Gels; D010743:Phospholipids; D012503:Saponins; D004928:Escin; D006493:Heparin; D006899:Mixed Function Oxygenases