[Peliosis hepatis, complicating treatment with anabolic steroids (author's transl)].
The clinical and pathological findings of peliosis hepatis are reported, complicating a long-term treatment with an anabolic steroid in a 19 year old male patient suffering from chronic aplastic anemia. Following a 15 months course of oxymetholone (Anapolon) a cholestatic jaundice developed without regression despite discontinuing the drug. 4 months later the patient expired as a consequence of his hematologic disease. At autopsy the liver showed a parenchymal type of peliosis hepatis with multiple blood filled cavities and focal liver cell necroses. The pathogenesis of this rare condition is discussed by means of literature demonstrating the hepatotoxic effect of C17-alkylated androgens.
D000293:Adolescent; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000740:Anemia / Q000188:drug therapy; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D001855:Bone Marrow Diseases / Q000188:drug therapy; D055598:Chemical Phenomena; D056486:Chemical and Drug Induced Liver Injury; D002621:Chemistry; D006801:Humans; D007565:Jaundice / Q000139:chemically induced; D008099:Liver / Q000473:pathology; D008134:Long-Term Care; D008297:Male; D009336:Necrosis; D010110:Oxymetholone / Q000009:adverse effects* / Q000627:therapeutic use; D011693:Purpura / Q000139:chemically induced*
D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D010110:Oxymetholone; D001663:Bilirubin
Peliosis hepatis, eine Komplikation der Anabolikatherapie