Experiments on infarct genesis caused by blockage of carbohydrate metabolism in guinea pig placentae.
The poisoning of pregnant guinea pigs with monoiodineacetate, an inhibitor of carbohydrate metabolism in the glyceraldehyde-3-phosphate dehydrogenase phase, leads within a few minutes to the formation of syncytial plasma protrusions in the maternal blood lacunae of the placenta. These protusions cause a primary white infarct where the degenerative process takes place--in the interlobium. An accumulation of erythrocytes originates in its arterial inflow area owing to the obstruction of the blood flow. Both primary infarct and accumulation of erythrocytes alter to form a single homogenous white infarct within a few days, together with the degenerative products of all cellular and syncytial elements. Timely substitution of glycolysis for pyruvate, i.e. within 20 min, during continued blockage of the glyceraldehyde-3-phosphate dehydrogenase, prevents the formation of an infarct.
D000818:Animals; D050260:Carbohydrate Metabolism; D004903:Erythrocyte Aggregation / Q000139:chemically induced; D005260:Female; D005337:Fibrin / Q000378:metabolism; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000037:antagonists & inhibitors; D006168:Guinea Pigs; D007238:Infarction / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D007461:Iodoacetates; D010920:Placenta / Q000098:blood supply* / Q000378:metabolism / Q000648:ultrastructure; D011247:Pregnancy; D011509:Proteoglycans / Q000378:metabolism; D011773:Pyruvates / Q000378:metabolism
D007461:Iodoacetates; D011509:Proteoglycans; D011773:Pyruvates; D005337:Fibrin; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases