[Comparative frequency of phenotypic resemblance of intrafamilial and interfamilial pairs of patients with generalized and focal epilepsy].
The correlation of the frequency of intra-paired phenotypical resemblance of intrafamilial (parents-children - 46 pairs, sibses - 26 pairs) and interfamilial (48 pairs) epilepsy according to the complex of constitutional and clinical features is studied. The intra-paired resemblance of the onset (homochronicity) and clinic (homotypia) of intrafamilial (even in different generations) epilepsy was discovered more often (41.3-88.5%) than interfamilial epilepsy (18.7-33.3%). The complete intra-paired phenotypical resemblance is the most characteristic for generalized, than focal intrafamiliar epilepsy. The comparison of the frequency of intra-paired resemblance according to constitutional features and the medium influence showed that the phenotypical manifestation of the epileptical genotype depends on the complex constellation of hereditary and medium factors being subjected to considerable modification by exogenes. However the clear difference of the frequency of intra-paired clinical resemblance of intra- and interfamilial epilepsy in considerable degree was caused rather by constitutional pecularities than by exogenes influence and may testify to possible hereditary heterogeneity of epilepsy.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D004828:Epilepsies, Partial / Q000175:diagnosis / Q000235:genetics; D004827:Epilepsy / Q000175:diagnosis / Q000235:genetics*; D006801:Humans; D010641:Phenotype
Sravnitel'naia chastota fenotipicheskogo skhodstva vnutriseme ĭnykh i mezhsemeĭnykh par bol'nykh generalizovannoĭ i fokal'noĭ épilepsieĭ