title: The frequency distribution of heavy chain classes and light chain types of 1,000 monoclonal immunoglobulins.
abstract: In 1000 patients with monoclonal gammapathies, heavy and light chains typing of the monoclonal Ig was performed. Class distribution of the heavy chains showed the following percentages : IgG = 56.60%; IgA = 17.0%; IgM = 14.5%; IgD = 0.3%; Light chain gammapathies (including Bence-Jones proteinuria without serum M-component) = 11.6%. The chi/lambda ratio was 663/337. Such results agree with figures from most statistical studies. Beside the well-known linkage between IgM and chi types in pathological macroglobulinemia, the quite high incidence of lambda chain type of light chain components is to be noticed. The frequency of gamma G type of M-component is significantly higher in patients demonstrating no symptoms of myeloma or lymphoma. chi/lambda ratio seems to be slightly affected by aetiological features.
mesh_terms: D001536:Bence Jones Protein / Q000652:urine; D006362:Heavy Chain Disease / Q000276:immunology; D006801:Humans; D006942:Hypergammaglobulinemia / Q000097:blood / Q000276:immunology* / Q000652:urine; D007070:Immunoglobulin A / Q000032:analysis; D007072:Immunoglobulin D / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007145:Immunoglobulin kappa-Chains / Q000032:analysis; D007146:Immunoglobulin lambda-Chains / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis*; D009101:Multiple Myeloma / Q000276:immunology; D009194:Myeloma Proteins / Q000032:analysis; D009369:Neoplasms / Q000276:immunology; D008258:Waldenstrom Macroglobulinemia / Q000276:immunology
chemical_list: D007070:Immunoglobulin A; D007072:Immunoglobulin D; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains; D007136:Immunoglobulins; D009194:Myeloma Proteins; D001536:Bence Jones Protein