Transfer of hypogammaglobulinemia in two inbred chicken strains by spleen cells from bursectomized donors.
Transfer of lymphoid cells from agammaglobulinemic donor chickens into 3- to 4-week-old irradiated recipients that had been surgically bursectomized at 2 to 3 weeks of age significantly depressed the ability of the antibody-forming apparatus to recover from irradiation. Antibody production to Brucella abortus and sheep erythrocytes remained much below control levels in BX donor-cell recipients of both chicken strains studied (SC and FP). Progressive loss of serum IgM and IgG was observed primarily in the FP strain resulting in complete agammaglobulinemia within 4 to 6 weeks after transfer of BX donor spleen cells. Serial transfer of this phenomenon was demonstrated in the SC strain.
D000361:Agammaglobulinemia / Q000276:immunology*; D000818:Animals; D000917:Antibody Formation; D002003:Brucella abortus / Q000276:immunology; D002060:Bursa of Fabricius / Q000601:surgery*; D002645:Chickens; D004912:Erythrocytes / Q000276:immunology; D007116:Immunization, Passive; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D012756:Sheep; D013154:Spleen / Q000276:immunology*
D007074:Immunoglobulin G; D007075:Immunoglobulin M