[Action of synthetic substance P (SP) on the respiration, general metabolism and systemic hemodynamics of the anesthetized dog].
In the anaesthetized Dog, synthetic substance P in one dose (0.5 mug/kg i.v.) induced a quick hypotensive but short-lasting action and a respiratory analeptic activity which only appeared with some delay and lasted more than one hour. The possibility of a rapid metabolization of synthetic SP is discussed.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002245:Carbon Dioxide; D002302:Cardiac Output / Q000187:drug effects; D004285:Dogs; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D007275:Injections, Intravenous; D008297:Male; D010100:Oxygen; D012119:Respiration / Q000187:drug effects*; D013373:Substance P / Q000378:metabolism / Q000494:pharmacology*; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects
D002245:Carbon Dioxide; D013373:Substance P; D010100:Oxygen
Etude de l'action de la substance P (SP) synthétique sur la respiration et le métabolisme général et sur l'hémodynanique systémique du chien anesthésié