[Principals of hormone substitution in thyrectomized patients with carcinoma of the thyroid gland (author's transl)].
The substitution of thyrectomized patients with carcinoma of the thyroid with L-thyroxin has advantages compared to a substitution with triiodothyronine, 200 mug T4/d are sufficient to obtain a negative TRH test in most patients. For security it is suggested to performe a general substitution of these patients with 300 mug T4/d. This dose is very well tolerated. To high doses of substitution cause a "damage" of the thyreotrop in a part of the patients. This is demonstrated by a transient thyreotropic insufficiency after withdrawal of the substitution. The results demonstrated here suggest that the central suppression of TSH secretion is better correlated with plasma T4 than plasma T3 levels.
D006801:Humans; D008134:Long-Term Care; D011182:Postoperative Care; D013964:Thyroid Neoplasms / Q000601:surgery; D013965:Thyroidectomy; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000008:administration & dosage* / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use; D013975:Thyroxine-Binding Proteins; D014284:Triiodothyronine / Q000008:administration & dosage / Q000097:blood
D013975:Thyroxine-Binding Proteins; D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine
Prinzipien der Hormonsubstitution bei thyrektomierten Schilddrüsenkarzinom-Patienten