[A factor activating protein synthesis in rat liver microsomes: its induction by a glucocorticoid hormone].
Injection of glucocorticoid hormone to adrenalectomized rats induces in liver microsomes a factor which stimulates polypeptide synthesis in a cell-free system. The factor is extractable from microsomes by 0.5 M KC1 followed by gel filtration, of the extract. Induction of the activator in glucocorticoid-treated rats contribute higher protein-synthesizing ability of the microsomes following hormone administration.
D000818:Animals; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism*; D010448:Peptide Initiation Factors; D011239:Prednisolone / Q000494:pharmacology*; D014176:Protein Biosynthesis; D051381:Rats; D013268:Stimulation, Chemical
D010448:Peptide Initiation Factors; D011239:Prednisolone
Etude d'un facteur activateur de la synthèse protéique dans les microsomes de foie de rat : son induction par l'hormone glucocorticoïde