Serum dopamine-beta-hydroxylase in psychiatric patients and normals. Effect of d-amphetamine and haloperidol.
Serum dopamine-beta-hydroxylase activity was estimated in groups of normals and of psychiatric patients, using a thin layer radiochromatographic method. The percentage of patients with schizophrenic and with depressive symptomatology was higher in the population with high enzyme activities. In addition, d-amphetamine given to normals caused an increase in the serum activity while haloperidol caused the opposite effect. The activity in serum is interpreted as a loss in the enzyme from the place it acts physiologically, with possible influence on the noradrenaline synthesis rate.
D003863:Depression / Q000201:enzymology; D003913:Dextroamphetamine / Q000494:pharmacology*; D004299:Dopamine beta-Hydroxylase / Q000097:blood*; D006220:Haloperidol / Q000494:pharmacology*; D006801:Humans; D001523:Mental Disorders / Q000201:enzymology*; D012559:Schizophrenia / Q000201:enzymology
D004299:Dopamine beta-Hydroxylase; D006220:Haloperidol; D003913:Dextroamphetamine