The metabolism of oxamniquine - a new schistosomicide.
The metabolism of oxamniquine, 6-hydroxymethyl-7-nitro-2-isopropylaminomethyl-1,2,3,4-tetrahydroquinoline, has been studied in the mouse, rat, hamster, rabbit, rhesus monkey, dog and man. Urinary excretion is a major route of elimination in man. The compound is converted to two metabolites, the major one arising from oxidation of the 6-hydroxymethyl group to a carboxyl group and the other by oxidation of the side chain to give the 2-carboxylic acid. There is a species at the dose levels used since both acidic metabolites were found in appreciable quantities only in the urine of mouse, rabbit, hamster and dog. The 2-carboxylic acid was not found in the urine of rhesus monkey and rat and occurred in only trace amounts in human urine.
D000818:Animals; D006224:Cricetinae; D004285:Dogs; D005260:Female; D000882:Haplorhini; D006801:Humans; D008253:Macaca mulatta; D008297:Male; D051379:Mice; D009600:Nitroquinolines / Q000378:metabolism*; D010073:Oxamniquine / Q000031:analogs & derivatives / Q000378:metabolism* / Q000652:urine; D011817:Rabbits; D051381:Rats; D012556:Schistosomicides / Q000378:metabolism* / Q000652:urine
D009600:Nitroquinolines; D012556:Schistosomicides; D010073:Oxamniquine