Expression of a mouse Ig V gene in antibodies of three immunoglobulin classes.
In an earlier study we found that some mouse strains, including the C57BL/6, produced irregular IgG anti-(4-hydroxy-3-nitrophenyl)acetyl (NP) antibodies to protein conjugates of this hapten. This antibody had heteroclitic fine specificity and a characteristic isoelectric focusing pattern. Breeding studies suggested that these qualities of the C57BL/6 anti-NP were controlled by a V gene of the heavy chain. We have now found that this V gene is expressed in anti-NP antibodies and plaque-forming cells of all major immunoglobulin classes: IgG, IgA and IgM.
D000818:Animals; D000918:Antibody Specificity; D001666:Binding Sites, Antibody; D005796:Genes; D006241:Haptens; D007070:Immunoglobulin A / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000096:biosynthesis; D007143:Immunoglobulin Heavy Chains / Q000096:biosynthesis*; D007075:Immunoglobulin M / Q000096:biosynthesis; D007156:Immunologic Memory; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009578:Nitrobenzenes / Q000276:immunology*; D013154:Spleen / Q000276:immunology
D006241:Haptens; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007143:Immunoglobulin Heavy Chains; D007075:Immunoglobulin M; D009578:Nitrobenzenes