title: [Kinetics of lithium].
abstract: After administration of easily soluble or ready dissolved lithium salts two phases can be defined in the changes of the blood level, and three in the case of lithium salts with a lesser solubility in water. The first phase from the time 0 to tmax is denoted by a massive invasion into the blood, this is counteracted by the beginnings of absorption into the tissue and elimination through the kidneys. In the second phase the absorption into the blood is returned to a constant even distribution; the absorption in the tissue and renal excretion rise notably. When the distribution is completed, the renal excretion is dominant. The kinetics of lithium are independent of the salt used. The salt, however, because of its solubility in oral administration can influence the absorption kinetics, tmax and the absolute blood level. By using Li2CO3 with a suitable speed of solubility a depot effect can be shown.
mesh_terms: D001711:Biotransformation; D001714:Bipolar Disorder / Q000097:blood / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008094:Lithium / Q000008:administration & dosage / Q000097:blood* / Q000627:therapeutic use; D012995:Solubility
chemical_list: D008094:Lithium
vernacular_title: Zur Kinetik des Lithiums.