Metabolic investigations during xylitol infusion.
The excretion of urinary acidic metabolites by 10 patients undergoing gastric or biliary tract surgery has been studied. Five patients were infused with xylitol and 5 with glucose. Four of the xylitol-infused patients had hyperglycollic aciduria and 3 of the glucose-infused patients had hyperlactic aciduria. There was no hyperoxaluria. Four of the xylitol-infused patients excreted more tetronic acids than any of the glucose-infused patients. Threonic acid was the predominant tetronic acid excreted by most (4/5) of the xylitol-infused subjects. Erythronic acid predominated in the glucose-infused as in control ambulant non-hospitalised subjects. It is suggested that these changes point to overloading of the transketolase pathway during xylitol infusion.
D001660:Biliary Tract Diseases / Q000601:surgery; D002264:Carboxylic Acids / Q000652:urine*; D005663:Furans / Q000652:urine; D005947:Glucose / Q000008:administration & dosage / Q000378:metabolism; D006016:Glycolates / Q000652:urine; D006801:Humans; D006885:Hydroxybutyrates / Q000652:urine; D007773:Lactates / Q000652:urine; D010070:Oxalates / Q000652:urine; D010288:Parenteral Nutrition; D011182:Postoperative Care; D013272:Stomach Diseases / Q000601:surgery; D013400:Sugar Acids / Q000652:urine; D014174:Transketolase / Q000378:metabolism; D014993:Xylitol / Q000008:administration & dosage / Q000378:metabolism
D002264:Carboxylic Acids; D005663:Furans; D006016:Glycolates; D006885:Hydroxybutyrates; D007773:Lactates; D010070:Oxalates; D013400:Sugar Acids; D014174:Transketolase; D005947:Glucose; D014993:Xylitol