IgG - subclass abnormalities in primary immunodeficiency diseases.
IgG-subclass levels were determined in the sera of 45 patients suffering from various types of immunodeficiency disease. Imbalances of IgG-subclass concentrations were found in 25 cases. IgG-4 levels were most frequently more depressed than the levels of the other subclasses. The percentage distribution of IgG-subclasses was normal in the remaining 20 sera. In a patient with autosomal recessive alymphocytic agammaglobulinemia, subclass concentrations drastically increased after bone marrow transplantion showing transient peaks of restricted heterogeneity. Normal IgG-subclass levels were reached at the end of the observation period.
D000328:Adult; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D017098:IgA Deficiency; D005779:Immunodiffusion; D007070:Immunoglobulin A / Q000032:analysis; D007128:Immunoglobulin Fragments / Q000172:deficiency; D007074:Immunoglobulin G / Q000145:classification; D007075:Immunoglobulin M / Q000032:analysis; D007153:Immunologic Deficiency Syndromes / Q000235:genetics / Q000276:immunology* / Q000628:therapy; D010375:Pedigree; D011863:Radioimmunoassay
D007070:Immunoglobulin A; D007128:Immunoglobulin Fragments; D007074:Immunoglobulin G; D007075:Immunoglobulin M