Recovery from paradoxical growth hormone responses in acromegaly after transphenoidal selective adenomectomy.
A patient with acromegaly was studied before and after treatment by transphenoidal removal of a pituitary adenoma. "Paradoxical" GH responses to the dopamine agonists L-DOPA and ampomorphine disappeared after surgery, with reversion of GH responsiveness to normal. TSH-releasing hormone (TRH)-induced GH release observed pre-operatively did not occur after surgery. The findings suggest that in certain cases, acromegaly is due to pituitary dysfunction alone.
D000172:Acromegaly / Q000188:drug therapy / Q000601:surgery*; D000236:Adenoma / Q000601:surgery*; D000328:Adult; D001058:Apomorphine; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D005951:Glucose Tolerance Test; D007987:Gonadotropin-Releasing Hormone; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D007328:Insulin; D007980:Levodopa; D007986:Luteinizing Hormone / Q000097:blood; D010911:Pituitary Neoplasms / Q000601:surgery*; D011388:Prolactin / Q000097:blood; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology
D007328:Insulin; D007987:Gonadotropin-Releasing Hormone; D007980:Levodopa; D013973:Thyrotropin-Releasing Hormone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013006:Growth Hormone; D001058:Apomorphine