title: Ultrastructural lesions on the surface of platelets associated with either blood coagulation or with antibody-mediated immune injury.
abstract: During blood coagulation ultrastructural lesions were produced on the platelet membrane. They were dependent on the presence of both thrombin and complement (C) and were morphologically identical to the C-dependent ultrastructural lesions (type II) seen in red cells subsequent to activation of C by the alternate mechanismmthough similar in shape they differed in size from ultrastructural lesions (type I) PRODUCED BY ACTIVATION OF C via the classic mechanismmlesions of type I were seen on the platelet surface subsequent to antibody-dependent activation of the C system.
mesh_terms: D000536:Aluminum Hydroxide; D001666:Binding Sites, Antibody; D001777:Blood Coagulation; D001792:Blood Platelets / Q000648:ultrastructure*; D002118:Calcium / Q000494:pharmacology; D003176:Complement C3 / Q000494:pharmacology; D003168:Complement Fixation Tests; D003165:Complement System Proteins; D004492:Edetic Acid / Q000494:pharmacology; D006801:Humans; D008274:Magnesium / Q000494:pharmacology; D008854:Microscopy, Electron; D013917:Thrombin / Q000494:pharmacology
chemical_list: D003176:Complement C3; D000536:Aluminum Hydroxide; D003165:Complement System Proteins; D004492:Edetic Acid; D013917:Thrombin; D008274:Magnesium; D002118:Calcium