title: Unusual clonal evolution in a case of chronic myelogenous leukemia.
abstract: Several unusual cytogenetic changes have occurred during the evolution of chronic myelogenous leukemia in a 32-year-old white male with this disease for 8 years. The first appearance of a hypodiploid cell line containing a dicentric marker occurred 2 years after diagnosis and this line was eliminated by several courses of therapy with hydroxyurea. A second clone, which had a partial deletion of the long arm of one of the number 8 chromosomes (8q-) was noted a year later, but this line has been refractory to intensive combination chemotherapy.
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations; D002999:Clone Cells; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use; D007951:Leukemia, Myeloid / Q000188:drug therapy / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic
chemical_list: D006918:Hydroxyurea