title: [Nalidixic acid levels in the serum with restricted renal function (author's transl)].
abstract: Simultaneous chemical and microbiological determinations during antibacterial therapy with normal doses of nalidixic acid (4 X 1 g/day) in patients with cystopyelonephritis and restricted renal function (serum creatinine 1.5-14.0 mg%) yielded markedly higher serum levels than in patients with normal kidney function. But no side effects could be observed on longer treatment up to two weeks. The active substance was thus present in the urine in lower concentrations than are found with normal renal function. However, they lie within the range of therapeutically necessary minimal inhibitory concentrations for various gram-negative pathogens. Reduction of the dose of nalidixic acid in severe renal insufficiency seems not to be necessary, and even illogical, because otherwise ineffective plasma and urine levels are obtained. The treatment was effective against sensitive pathogens.
mesh_terms: D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000378:metabolism; D007700:Kinetics; D008657:Metabolic Clearance Rate; D009268:Nalidixic Acid / Q000008:administration & dosage / Q000009:adverse effects / Q000097:blood* / Q000378:metabolism / Q000627:therapeutic use; D011704:Pyelonephritis / Q000188:drug therapy
chemical_list: D009268:Nalidixic Acid
vernacular_title: Nalidixinsäure-Serumspiegel bei eingeschränkter Nierenfunktion