Quinacrine in the management of malignant pleural effusion.
Twenty-five patients with malignant pleural effusion were treated with a single intrapleural dose of Quinacrine. Eighteen patients (72 per cent) had a significant response, with no reaccumulation of fluid for at least 2 months following treatment up to a maximum of 18 months in 2 patients. Seven patients (28 per cent) survived for longer than 1 year without evidence of recurrent effusion.
D001943:Breast Neoplasms / Q000188:drug therapy; D001984:Bronchial Neoplasms / Q000188:drug therapy; D005260:Female; D006801:Humans; D010996:Pleural Effusion / Q000188:drug therapy*; D010997:Pleural Neoplasms / Q000188:drug therapy*; D011796:Quinacrine / Q000627:therapeutic use*
D011796:Quinacrine