Hepatic ductular hypoplasia associated with characteristic facies, vertebral malformations, retarded physical, mental, and sexual development, and cardiac murmur.
Among 30 children with hepatic ductular hypoplasia and normal extrahepatic bile ducts, 15 formed a hemogeneous, readily recognizable group. In addition to chronic cholestasis, they have characteristic facies, a mesosystolic murmur, vertebral arch defects, growth retardation, mental retardation, and hypogonadism. Typical biochemical and histologic features aid in differentiation of this group from patients with other varieties of biliary disease.
D000015:Abnormalities, Multiple; D000293:Adolescent; D001652:Bile Ducts / Q000473:pathology; D001653:Bile Ducts, Intrahepatic / Q000002:abnormalities*; D001707:Biopsy, Needle; D002648:Child; D002675:Child, Preschool; D002779:Cholestasis / Q000150:complications / Q000473:pathology; D005145:Face; D005260:Female; D006130:Growth Disorders / Q000150:complications*; D006326:Heart Auscultation; D006337:Heart Murmurs; D006801:Humans; D007006:Hypogonadism / Q000150:complications*; D007223:Infant; D008607:Intellectual Disability / Q000150:complications*; D008297:Male; D010375:Pedigree; D016135:Spinal Dysraphism / Q000150:complications* / Q000473:pathology; D013577:Syndrome; D013737:Testis / Q000473:pathology; D014972:Xanthogranuloma, Juvenile / Q000150:complications / Q000473:pathology