Antimicrobial activities and antagonists of bacilysin and anticapsin.
The dipeptide antibiotic bacilysin is active against a wide range of bacteria and against Candida albicans. Its C-terminal amino acid, anticapsin, is a very poor antibacterial agent. The activities of both substances are strongly dependent on the nature of the culture medium. In a minimal medium the minimum inhibitory concentration for bacilysin with E. coli B is 10(-3) mug ml(-1). The action of bacilysin amino acids. With several bacteria, bacilysin-resistant mutants are found in unusually large numbers. It is suggested that peptide and amino acid transport systems play a role in these phenomena. The antimicrobial action of bacilysin is also inhibited by glucosamine and N-acetylglucosamine. This antibiotic may therefore interfere with glucosamine synthesis and thus with the synthesis of microbial cell walls.
D000117:Acetylglucosamine / Q000494:pharmacology; D000409:Alanine / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000378:metabolism*; D002176:Candida albicans / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D003512:Cyclohexanones / Q000037:antagonists & inhibitors / Q000494:pharmacology; D004151:Dipeptides / Q000037:antagonists & inhibitors / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects; D005944:Glucosamine / Q000494:pharmacology; D009154:Mutation; D012485:Salmonella typhi / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D003512:Cyclohexanones; D004151:Dipeptides; C000097:anticapsin; C006674:bacilysin; D005944:Glucosamine; D000409:Alanine; D000117:Acetylglucosamine