title: The induction of non-specific autoimmune phenomena by radiotherapy.
abstract: Induction of autoimmune phenomena by radiotherapy was evaluated with fluorescent antinuclear antibodies (FANA), latex fixation, and C'3 complement. 27 random serum samples obtained prior to radiotherapy revealed only a low C'3 in a patient with Hodgkin's disease and Sjögren's syndrome. 33 random serum samples obtained after radiotherapy revealed 7 positive values (5 FANA, 1 latex fixation, and 1 C'3). The increase in positive values was statistically significant.
mesh_terms: D000974:Antibodies, Antinuclear / Q000032:analysis; D000917:Antibody Formation / Q000528:radiation effects*; D001323:Autoantibodies / Q000528:radiation effects; D003176:Complement C3 / Q000032:analysis; D003168:Complement Fixation Tests; D005455:Fluorescent Antibody Technique; D006801:Humans; D007109:Immunity / Q000528:radiation effects*; D005779:Immunodiffusion; D007841:Latex Fixation Tests; D011830:Radiation Effects; D011878:Radiotherapy / Q000009:adverse effects*; D011879:Radiotherapy Dosage; D012217:Rheumatoid Factor / Q000032:analysis
chemical_list: D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D003176:Complement C3; D012217:Rheumatoid Factor