Significance of HLA and blood-group incompatibility in spontaneous abortion.
The frequencies of antigen-incompatible matings within the HLA, Rhesus, Lutheran, MN, S. Lewis, Kell, P and Duffy systems were studied in 481 parents of karyotyped spontaneous abortuses. The results were compared with the calculated mating frequencies in control samples consisting of 1,197 (HLA) and 12,123 (the remaining eight systems) individuals, respectively. The only significant difference observed at the 5% level was an increased frequency of matins in which the mother was Lu (a+) and had a karyotypically abnormal abortus. It is concluded that antigen incompatibility between the parents within the nine systems studied is not important in the aetiology of early spontaneous abortion or causative in the origin of chromosome anomalies in the foetus.
D000022:Abortion, Spontaneous / Q000235:genetics / Q000276:immunology*; D001787:Blood Group Incompatibility; D004375:Duffy Blood-Group System; D005260:Female; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D006801:Humans; D007626:Kell Blood-Group System; D007983:Lewis Blood Group Antigens; D008188:Lutheran Blood-Group System; D008951:MNSs Blood-Group System; D008297:Male; D010127:P Blood-Group System; D010641:Phenotype; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000235:genetics; D012204:Rh-Hr Blood-Group System
D004375:Duffy Blood-Group System; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D007626:Kell Blood-Group System; D007983:Lewis Blood Group Antigens; D008188:Lutheran Blood-Group System; D008951:MNSs Blood-Group System; D010127:P Blood-Group System; D012204:Rh-Hr Blood-Group System