Preparation of Rocky Mountain spotted fever vaccine suitable for human immunization.
Rocky Mountain spotted fever vaccine was produced from rickettsiae grown in chicken embryo cells in roller bottle cultures. The rickettsiae were concentrated and purified by passage through a sucrose gradient and inactivated with formalin. This vaccine satisfactorily passed preinactivation and final container testing and is believed to be superior to the presently available yolk sac vaccine.
D000818:Animals; D004353:Drug Evaluation, Preclinical; D005557:Formaldehyde / Q000494:pharmacology; D006168:Guinea Pigs; D006801:Humans; D007114:Immunization; D007120:Immunochemistry; D012284:Rickettsia rickettsii / Q000187:drug effects / Q000276:immunology*; D012290:Rickettsial Vaccines; D012373:Rocky Mountain Spotted Fever / Q000517:prevention & control*; D014612:Vaccines; D014613:Vaccines, Attenuated
D012290:Rickettsial Vaccines; D014612:Vaccines; D014613:Vaccines, Attenuated; D005557:Formaldehyde