title: Therapeutic midtrimester abortion by the intra-uterine administration of prostaglandins. Experience of Groote Schuur Hospital, 1974-1975.
abstract: During the period from 1 January 1974 to 31 December 1975, 71 therapeutic midtrimester abortions were performed at Groote Schuur Hospital by the intra-uterine administration of prostaglandins. Both the extra- and intra-amniotic routes of administration proved to be uniformly successful but the latter route was associated with fewer side-effects. The intra-amniotic administration of 30 mg prostaglandin F2alpha in combination with 60 g urea is the recommended method for achieving midtrimester abortion. If the method described is strictly adhered to, it provides a single-dose regimen which is uniformly successful and which is associated with few complications.
mesh_terms: D000032:Abortion, Therapeutic; D000293:Adolescent; D000328:Adult; D000650:Amnion; D002404:Catheterization; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000517:prevention & control; D006801:Humans; D017053:Infection Control; D007263:Infusions, Parenteral; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011458:Prostaglandins E / Q000008:administration & dosage* / Q000009:adverse effects; D011460:Prostaglandins F / Q000008:administration & dosage* / Q000009:adverse effects; D014947:Wounds and Injuries / Q000517:prevention & control
chemical_list: D011458:Prostaglandins E; D011460:Prostaglandins F