[Platelet membrane glycoprotein defect, molecular basis for the abnormal adhesion of platelets to the subendothelium in thrombocytic hemorrhagic dystrophy].
A large reduction in the staining capacity of a glycoprotein of 155 000 M.W. was observed in the platelets of 2 macrogiant platelets syndrome patients, associated with a reduced platelet adhesion to rabbit aorta subendothelium and with the presence of von Willebrand protein on these platelets as revealed by an antihuman factor VIII-Von Willebrand protein rabbit antibody. These results led the authors to propose a strong hypothesis on the role of this glycoprotein rich in sialic acid - in platelet adhesion to subendothelium.
D000328:Adult; D000818:Animals; D001792:Blood Platelets / Q000032:analysis / Q000648:ultrastructure; D002462:Cell Membrane / Q000378:metabolism; D005169:Factor VIII / Q000032:analysis; D005260:Female; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D008297:Male; D009092:Mucous Membrane / Q000378:metabolism; D010973:Platelet Adhesiveness; D011817:Rabbits; D013920:Thrombocythemia, Essential / Q000097:blood*
D006023:Glycoproteins; D005169:Factor VIII
Défaut d'une glycoprotéine de membrane plaquettaire, base moléculaire de l'anomalie d'adhésion des plaquettes au sous-endothélium dans la dystrophie thrombocytaire hémorragique