Benign epilepsy of childhood with centrotemporal EEG foci: a genetic study.
Nineteen probands with benign epilepsy of childhood and centrotemporal EEG foci (rolandic discharges), 36 of their full parents, and 34 full siblings were included in a genetic study. In these sibships (excluding probands), 15% (5/34) had seizures and rolandic discharges, and 19% (6/32) had rolandic discharges alone. Of the full parents, 11% (5/38) had seizures in chilhood but none in adult life. Only 1 parent (3%) of 36 had rolandic discharges. There was no differnence with sex. The results were tested against different genetic hypotheses and indicate that an autosomal dominant gene with age-dependent penetrance is responsible for the EEG trait.
D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology; D005260:Female; D005787:Gene Frequency; D005799:Genes, Dominant; D006801:Humans; D008297:Male; D010375:Pedigree; D010641:Phenotype