Immunologic study of antigens and molecular hybridization of nucleic acids from milk of breast cancer patients.
Comparative study has shown that by the gel diffusion assay both anti-HEp-2 virus serum and anti-breast cancer milk ultrasediment serum precipitated an identical antigen in human milk specimens, which was not identical with the group specific antigen of the HEp-2 virus. At the same time tha anti-breast cancer milk serum did not precipitate the HEp-2 virus. However, molecular hybridization experiments revealed nucleotide sequences homologous to nucleic acids of oncornavirus of D-type in milk obtained from breast carcinoma patients as well as in milk of healthy donors.
D000951:Antigens, Neoplasm / Q000302:isolation & purification; D000956:Antigens, Viral / Q000302:isolation & purification; D001483:Base Sequence; D001943:Breast Neoplasms / Q000276:immunology*; D004273:DNA, Neoplasm / Q000276:immunology; D004279:DNA, Viral / Q000276:immunology; D005260:Female; D006801:Humans; D005779:Immunodiffusion; D008895:Milk, Human / Q000276:immunology*; D009693:Nucleic Acid Hybridization; D009858:Oncogenic Viruses / Q000276:immunology*; D012334:RNA, Neoplasm / Q000276:immunology
D000951:Antigens, Neoplasm; D000956:Antigens, Viral; D004273:DNA, Neoplasm; D004279:DNA, Viral; D012334:RNA, Neoplasm