Electrocardiographic effects of right atrial pacing and nitroglycerin in atherosclerotic rhesus monkeys.
Right atrial pacing at rapid heart rates induced ischemic S-T segment changes in 19 atherosclerotic, male rhesus monkeys. Prior administration of nitroglycerin (100 mug/kg, i.v.) prevented the S-T segment alteration at a given pacing rate in 5 animals, attenuated it in 12 others, and had no effect in the remaining 2. The results of these studies are similar to earlier ones in atherosclerotic rabbits.
D000818:Animals; D001161:Arteriosclerosis / Q000503:physiopathology*; D016275:Atrial Function; D003326:Coronary Circulation; D004562:Electrocardiography; D000882:Haplorhini; D006339:Heart Rate / Q000187:drug effects; D007511:Ischemia / Q000503:physiopathology; D008253:Macaca mulatta; D008297:Male; D005996:Nitroglycerin / Q000494:pharmacology*; D010138:Pacemaker, Artificial
D005996:Nitroglycerin