title: Hemopexin synthesis in vitro by human fetal tissues.
abstract: Serum concentrations of hemopexin, transferrin, and albumin were measured for 12 fetuses between 14 and 36 weeks of gestational age. Hemopexin levels ranged from 7 to 64 mug/ml, transferrin levels ranged from 280 to 928 mug/ml, and albumin levels ranged from 13 to 59 mg/ml. In general, the serum concentrations of these three proteins increased with advancing gestation. Placenta, thymus, and colon did not incorporate 14C-labeled amino acids into hemopexin, transferrin, or albumin. By contrast radioimmune precipitates for five culture supernatants of liver indicated significant synthesis of albumin and hemopexin. [14C]Albumin accounted for 22-73% and [14C]hemopexin 1.1-4.2% of the total 14C-labeled proteins. In each instance, the [14C]transferrin was below 1% of the total 14C-labeled proteins.
mesh_terms: D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D002250:Carbon Radioisotopes; D003106:Colon / Q000378:metabolism; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D005333:Fetus / Q000378:metabolism*; D005865:Gestational Age; D000882:Haplorhini; D006466:Hemopexin / Q000032:analysis / Q000096:biosynthesis*; D006801:Humans; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D011817:Rabbits; D051381:Rats; D012709:Serum Albumin / Q000032:analysis / Q000096:biosynthesis; D013950:Thymus Gland / Q000378:metabolism; D014168:Transferrin / Q000032:analysis / Q000096:biosynthesis
chemical_list: D000596:Amino Acids; D002250:Carbon Radioisotopes; D012709:Serum Albumin; D014168:Transferrin; D006466:Hemopexin