Disposition of disodium cromoglycate administered in three particle sizes.
1 Disodium cromoglycate (DSCG) was administered in three particle sizes to five human subjects. 2 Urinary excretion of DSCG, as a proportion of the dose, was highest following small particles; the lower values recorded following intermediate-sized and large particles were similar. 3 DSCG deposited in the mouth was highest following large particles; the lower values recorded following intermediate-sized and small particles were similar. 4 The data were examined in relation to the recent observation that the protective effect of small particles of DSCG is dramatically superior to that of large particles.
D000328:Adult; D004205:Cromolyn Sodium / Q000008:administration & dosage* / Q000652:urine; D006801:Humans; D008297:Male; D010316:Particle Size; D012138:Respiratory Therapy
D004205:Cromolyn Sodium