Prostaglandin d2 as a potential antithrombotic agent.
Prostaglandin D2 was found to be a potent inhibitor of platelet aggregation. Aggregation of human platelets by ADP, collagen and prostaglandin G2 was inhibited more strongly by PGD2 than by PGE1. Although ADP-induced aggregation of rabbit platelets was inhibited more strongly by PGE1 than by PGD2 the latter prostaglandin gave a more long-lasting inhibitory effect on platelet aggregation following intravenous or oral administration. These results coupled with the finding that PGD2 has less hypotensive effects on the cardiovascular system than PGE1 suggest the possible use of PGD2 as an antithrombotic agent.
D000244:Adenosine Diphosphate / Q000037:antagonists & inhibitors; D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D001792:Blood Platelets / Q000201:enzymology; D001831:Body Temperature / Q000187:drug effects; D003094:Collagen / Q000037:antagonists & inhibitors; D006224:Cricetinae; D003864:Depression, Chemical; D005260:Female; D005298:Fertility / Q000187:drug effects; D000882:Haplorhini; D006801:Humans; D010974:Platelet Aggregation; D011448:Prostaglandin Antagonists; D011453:Prostaglandins / Q000494:pharmacology*; D011817:Rabbits; D013268:Stimulation, Chemical
D011448:Prostaglandin Antagonists; D011453:Prostaglandins; D000244:Adenosine Diphosphate; D003094:Collagen; D000262:Adenylyl Cyclases