Parathyroid hormone secretion in the rat:  effect of aminophylline (38536).
Administration of aminophylline to intact rats did not cause a change in serum Ca, but did cause a significant increase in serum PTH.  Administration of EDTA alone caused hypocalcemia, and a greater increase in PTH than that caused by aminophylline alone.  Aminophylline plus EDTA given togeather caused no greater hypocalcemia, but a significantly greater increase in PTH than that by EDTA alone.  Therefore, aminophylline increased PTH secretion when given alone, and also enhanced the PTH secretion stimulated by EDTA-induced hypocalcemia in vivo.
D000628:Aminophylline / Q000494:pharmacology*; D000818:Animals; D002118:Calcium / Q000097:blood; D004357:Drug Synergism; D004492:Edetic Acid / Q000494:pharmacology; D008297:Male; D010281:Parathyroid Hormone / Q000378:metabolism*; D051381:Rats; D013268:Stimulation, Chemical
D010281:Parathyroid Hormone; D000628:Aminophylline; D004492:Edetic Acid; D002118:Calcium