title: Naphthyridinomycin, a new broad-spectrum antibiotic.
abstract: A new antibiotic, naphthyridinomycin, was isolated in crystalline form from the culture filtrate of Streptomyces lusitanus AY B-1026. The antibiotic is active against a large number of both gram-positive and gram-negative bacteria, and inactive against Candida albicans, Trichophyton granulosum and Microsporum gypseum. The antibiotic is toxic in mice.
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D004269:DNA, Bacterial / Q000378:metabolism; D004926:Escherichia coli / Q000187:drug effects; D051379:Mice; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013302:Streptomyces / Q000032:analysis*
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial