The effect of ionizing irradiation on the collagen general metabolism in normal and adrenalectomized rats.
The effect of doses of 100, 250, 500, and 700 R on the urinary excretion of hydroxyproline in normal and adrenalectomized rats was followed over a period of 30 days. Urinary hydroxyproline is decreased by 100 and 250 R doses and increased by those of a 500 and 700 R. The first effect is explained by an increase of the insolubility of collagen as a result of the appearance of additional intermolecular crosslinkages, and the second one by breakage of the mentioned linkages. Adrenalectomized rats, both normal and irradiated, show a more significant decrease in the urinary excretion of hydroxyproline. Results are discussed on the basis of related bibliography, outlining the practical utility of the research.
D000311:Adrenal Glands / Q000502:physiology*; D000315:Adrenalectomy; D000818:Animals; D003094:Collagen / Q000378:metabolism / Q000528:radiation effects*; D006909:Hydroxyproline / Q000652:urine; D011830:Radiation Effects; D051381:Rats
D003094:Collagen; D006909:Hydroxyproline