[Local anesthetic effect of several lipid-soluble compounds on the carbamylcholine response of the Electrophorus electroplax and the acetylcholine binding to the cholinergic receptor of Torpedo].
Several lipid soluble compounds: "Triton X-100", "Emulphogene BC-720" and 8-doxyl-palmitic acid behave-like local anesthetics on the in vivo response of Electrophorus electroplax to carbamylcholine and on the in vitro binding of 3-H acetylcholine to the membrane-bound cholinergic receptor from Torpedo.
D000109:Acetylcholine / Q000378:metabolism; D000779:Anesthetics, Local; D000818:Animals; D001665:Binding Sites; D002217:Carbachol / Q000378:metabolism; D002794:Choline / Q000031:analogs & derivatives / Q000378:metabolism; D003619:Dansyl Compounds; D003864:Depression, Chemical; D004557:Electric Organ / Q000187:drug effects*; D004586:Electrophoresis; D004593:Electrophorus; D005399:Fishes; D050356:Lipid Metabolism; D008566:Membranes / Q000378:metabolism; D008856:Microscopy, Fluorescence; D010169:Palmitic Acids / Q000494:pharmacology*; D011092:Polyethylene Glycols / Q000494:pharmacology*; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*; D011950:Receptors, Cholinergic; D012995:Solubility; D013268:Stimulation, Chemical; D013329:Structure-Activity Relationship
D000779:Anesthetics, Local; D003619:Dansyl Compounds; D010169:Palmitic Acids; D000644:Quaternary Ammonium Compounds; D011950:Receptors, Cholinergic; D011092:Polyethylene Glycols; D002217:Carbachol; D002794:Choline; D000109:Acetylcholine
Effet anesthésique local de plusieurs composés liposolubles sur la réponse de l'électroplaque de Gymnote à la carbamylcholine et sur la liaison de l'acétylcholine au récepteur cholinergique de Torpille