Lack of TRH-induced TSH secretion in a patient with Klinefelter's syndrome: a case report.
In a 41 year-old patient with Klinefelter's syndrome, a failure of TRH-induced TSH secretion was noticed. Low 131I-thyroid uptake, together with the elevation following exogenous TSH administration, indicates that the defective locus exists in the hypothalamus or pituitary resulting in an impaired secretion of TSH. Such a defect may underlie thyroid dysfunction often associated with Klinefelter's syndrome.
D000328:Adult; D006801:Humans; D007713:Klinefelter Syndrome / Q000503:physiopathology*; D008297:Male; D013961:Thyroid Gland / Q000503:physiopathology; D013972:Thyrotropin / Q000378:metabolism*; D013973:Thyrotropin-Releasing Hormone
D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin