title: Intravenous co-trimoxazole ("Bactrim") in the treatment of acute pyelonephritis.
abstract: Patients with acute pyelonephritis may be extremely ill and have a complicating septicaemia. This may necessitate the parenteral administration of an appropriate antibacterial agent. This paper reports the use of intravenous co-trimoxazole in two young women with severe acute pyelonephritis. 101 ml of co-trimoxazole (800 mg sulphamethoxazole and 160 mg trimethoprim) was added to 500 ml of 5% dextrose in water and infused over a 90-min period. This treatment was given every 12 h for five doses, before switching to oral co-trimoxazole. The treatment was clinically and bacteriologically successful and no side effects were noted.
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D011704:Pyelonephritis / Q000188:drug therapy*; D013420:Sulfamethoxazole / Q000008:administration & dosage / Q000627:therapeutic use*; D014295:Trimethoprim / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D004338:Drug Combinations; D014295:Trimethoprim; D013420:Sulfamethoxazole