Changes in 80S ribosomes from Drosophila melanogaster with age.
A 23% reduction in the amount of 80S ribosomes extracted from young and old male Drosophila melanogaster on a per g wet weight basis was demonstrated. Furthermore, a significant alteration in the structural integrity of the ribosomal RNA-protein complex from older flies as demonstrated by the dissociation of protein from the 80S particle in the presence of varying concentrations of KC1 was observed.
D000375:Aging; D000818:Animals; D004331:Drosophila melanogaster; D008297:Male; D011189:Potassium Chloride / Q000494:pharmacology; D012335:RNA, Ribosomal / Q000378:metabolism; D012269:Ribosomal Proteins / Q000378:metabolism; D012270:Ribosomes / Q000187:drug effects / Q000378:metabolism
D012335:RNA, Ribosomal; D012269:Ribosomal Proteins; D011189:Potassium Chloride