The problem of post-psychotic schizophrenic depressions and their pharmacological induction. Long-term studies with fluspirilene and penfluridol and single-blind trial with fluphenazine-decanoate and flupenthixol-decanoate.
The authors discuss the historical aspects, as well as the various etiological and clinical factors which contribute to the so-called pharmacogenically induced depressions during treatment by means of neuroleptics generally, and long-term neuroleptics especially. An open study on 161 schizophrenic patients treated by means of fluspirilene and 123 patients treated by means of penfluridol is described. A single blind trial on 48 patients, by means of fluphenazine-decanoate and flupenthixol-decanoate, which compares the possible depression-inducing or antidepressant activity of the above drugs, is presented. The criteria for evaluating drug-induced depressions and their two clinical types are discussed.
D000328:Adult; D000928:Antidepressive Agents; D002986:Clinical Trials as Topic; D003863:Depression / Q000139:chemically induced; D005260:Female; D005475:Flupenthixol / Q000009:adverse effects* / Q000627:therapeutic use; D005476:Fluphenazine / Q000009:adverse effects* / Q000627:therapeutic use; D005484:Fluspirilene / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008134:Long-Term Care; D008297:Male; D010395:Penfluridol / Q000009:adverse effects* / Q000627:therapeutic use; D010555:Personality Inventory; D010880:Piperidines / Q000009:adverse effects*; D012559:Schizophrenia / Q000188:drug therapy*; D013141:Spiro Compounds / Q000009:adverse effects*; D013892:Thioxanthenes / Q000009:adverse effects*
D000928:Antidepressive Agents; D010880:Piperidines; D013141:Spiro Compounds; D013892:Thioxanthenes; D010395:Penfluridol; D005484:Fluspirilene; D005475:Flupenthixol; D005476:Fluphenazine