Reduced severity of Rh-haemolytic disease after anti-D immunoglobulin.
A total of 2459 Rh-negative women who received anti-D immunoglobulin after a Rh-positive pregnancy were followed up in at least one subsequent pregnancy. There was a failure of protection rate of 1-6%. Follow-up of 53 subsequent infants of mother in whom protection had failed showed that the infants were less severely affected than would have been expected. This was confirmed by a comparative statistical analysis of the present series and a series of first affected cases before anti-D immunoglobulin was available, using the antibody titre during pregnancy and the haemoglobin levels at delivery.
D000906:Antibodies / Q000032:analysis; D000917:Antibody Formation; D004899:Erythroblastosis, Fetal / Q000517:prevention & control*; D005260:Female; D005312:Fetal Blood; D005313:Fetal Death; D005500:Follow-Up Studies; D006452:Hemoglobinometry; D006801:Humans; D007231:Infant, Newborn; D007518:Isoantibodies / Q000008:administration & dosage*; D011247:Pregnancy; D012204:Rh-Hr Blood-Group System
D000906:Antibodies; D007518:Isoantibodies; D012204:Rh-Hr Blood-Group System