title: A method for the preparation and quality control of 68Ga radiopharmaceuticals.
abstract: Gallium-68 (T 1/2 68 min) is a convenient label for radiopharmaceuticals designed for use with positron detection devices; the radionuclide is a generator produce obtained from its parent 68Ge (T 1/2 287 days). The labeling procedure itself is simple since gallium forms complexes without the use of reducing agents. However, 68Ga is present in the generator eluant as the gallium-EDTA chelate and must be separated from EDTA prior to its use as a label. A rapid and efficient method for achieving this separation and for preparing 68Ga-labeled compounds for human use has been developed. Paper chromatography is employed to determine the amount of each major gallium species present in preparations of two gallium complexes; 68Ga-adenosine triphosphate and 68Ga-citrate.
mesh_terms: D000255:Adenosine Triphosphate / Q000032:analysis; D002854:Chromatography, Paper; D002951:Citrates / Q000032:analysis; D004492:Edetic Acid / Q000032:analysis; D005710:Gallium Radioisotopes / Q000032:analysis; D006878:Hydroxides / Q000032:analysis; D007553:Isotope Labeling / Q000379:methods; D010710:Phosphates / Q000032:analysis; D011786:Quality Control
chemical_list: D002951:Citrates; D005710:Gallium Radioisotopes; D006878:Hydroxides; D010710:Phosphates; D000255:Adenosine Triphosphate; D004492:Edetic Acid