Central effects of thyrotropin-releasing factor (TRF); interaction with some antipsychotic drugs.
The behavioral effects (tremors, tail erection, increased motility) of intracerebrally injected TRF are enhanced by pretreatment with chlorpromazine, reserpine and sulpiride; haloperidol does not exert appreciable effects. L-Dopa attenuates or abolishes the potentiation.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002746:Chlorpromazine / Q000494:pharmacology*; D004347:Drug Interactions; D006220:Haloperidol / Q000494:pharmacology*; D007276:Injections, Intraventricular; D007980:Levodopa / Q000494:pharmacology; D051379:Mice; D012110:Reserpine / Q000494:pharmacology*; D013469:Sulpiride / Q000494:pharmacology*; D013973:Thyrotropin-Releasing Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
D007980:Levodopa; D013973:Thyrotropin-Releasing Hormone; D013469:Sulpiride; D012110:Reserpine; D006220:Haloperidol; D002746:Chlorpromazine