Determination of blood serum protein reactivity in children with behavior disturbances.
The researches were carried out on two groups of children: normals and with behavior disturbances. The serum cationic state was determined by an original method, using heparin as cautions exchanger in physiological pH, and the protein reactivity; the electrophoretic mobility of serum proteins at pH 7.4; total soduim and serum proteins. The obtained results show that serum proteins in children with behavior disturbances differ from those of normals, having: 1) smaller number of serotonin-fixing sites, 2) higher strength interaction between the serotonin and proteins, 3) lower resistance to the denaturant agents which has as a consequence the increase of cationic activity in the serum, and an increased electrophoretic mobility. The data are discussed and interpreted as perturbations in the electrolytes exchange (Na+, especially) in the integration centres of the autonomic functions.
D000293:Adolescent; D001798:Blood Proteins / Q000032:analysis; D001925:Brain Damage, Chronic / Q000097:blood*; D002648:Child; D002653:Child Behavior Disorders / Q000097:blood*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006948:Hyperkinesis / Q000097:blood*; D008297:Male; D012701:Serotonin / Q000097:blood; D012964:Sodium / Q000097:blood
D001798:Blood Proteins; D012701:Serotonin; D012964:Sodium