Successful arterial substitution with modified human umbilical vein.
Human umbilical veins were prepared as vascular grafts by tanning with dialdehyde starch or gluteraldehyde and by structural re-inforcement with an outer polyester fiber mesh. These grafts were implanted in baboons in the aortoiliac position for periods of 3 days to 9 months. There was no aneurysm formation and there was an excellent maintenance of patency as well as function. Histologic evaluation of the graft materials showed a dense collagen layer within the encircling polyester fiber mesh. A multicellular subintimal layer formed a discrete inner capsule. The inflammatory response with the umbilical component was insignificant. There was no evidence of rejection. This study suggests that the modified umbilical vein can serve as a satisfactory blood conduit. Experience with three short-term clinical implants supports the applicability and potential for this new vascular graft.
D000818:Animals; D001158:Arteries / Q000601:surgery; D000882:Haplorhini; D006801:Humans; D007866:Leg / Q000098:blood supply; D010215:Papio; D011108:Polymers; D013526:Surgical Mesh; D014181:Transplantation Immunology; D014183:Transplantation, Heterologous; D014184:Transplantation, Homologous; D014471:Umbilical Veins / Q000166:cytology / Q000637:transplantation*
D011108:Polymers