High-dose treatment of rats with perphenazine enanthate.
Previously we demonstrated an approximately 20% loss of nerve cells in the basal ganglia of rats following treatment with perphenazine enanthate 3.4 mg/kg s.c. every 2nd week during 12 months. If the treatment period was only 2 or 3 months no significant differences were found.
D000818:Animals; D001479:Basal Ganglia / Q000187:drug effects*; D002452:Cell Count; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D003342:Corpus Striatum / Q000648:ultrastructure; D004409:Dyskinesia, Drug-Induced / Q000209:etiology; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009474:Neurons / Q000187:drug effects; D010546:Perphenazine / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats
D009419:Nerve Tissue Proteins; D010546:Perphenazine