Evidence for specific transport of uridine diphosphate galactose across the Golgi membrane of rat mammary gland.
The inhibition of lactose synthesis by UDP-glucose, UDP-glucuronate and, less so, by UDP-N-acetylglucosamine was markedly smaller in preparations of "intact" than of lysed vesicles derived from the Golgi apparatus of lactating rat mammary gland. This constitutes evidence for a specific, probably facilitated, transport of UDP-galactose across the Golgi membrane.
D000818:Animals; D001692:Biological Transport; D005260:Female; D006056:Golgi Apparatus / Q000378:metabolism*; D007774:Lactation; D007785:Lactose / Q000378:metabolism; D007788:Lactose Synthase / Q000037:antagonists & inhibitors; D008321:Mammary Glands, Animal / Q000378:metabolism* / Q000648:ultrastructure; D008566:Membranes / Q000378:metabolism; D011247:Pregnancy; D051381:Rats; D014531:Uridine Diphosphate Galactose / Q000378:metabolism*; D014532:Uridine Diphosphate Glucose / Q000494:pharmacology; D014535:Uridine Diphosphate Glucuronic Acid / Q000494:pharmacology; D014537:Uridine Diphosphate N-Acetylglucosamine / Q000494:pharmacology; D014539:Uridine Diphosphate Sugars / Q000378:metabolism*
D014539:Uridine Diphosphate Sugars; D014535:Uridine Diphosphate Glucuronic Acid; D014531:Uridine Diphosphate Galactose; D014537:Uridine Diphosphate N-Acetylglucosamine; D007788:Lactose Synthase; D007785:Lactose; D014532:Uridine Diphosphate Glucose