[Immunogenic properties of brucella protective antigen upon revaccination].
The authors generalized the materials on the experimental study of the immunological efficacy of brucella protective antigen in revaccination. Revaccination 12 months after the immunization of guinea pigs with an antigen in a dose equal to the primary immunization dose (0.6 mg) reproduced the protection from the infection with a virulent Br. melitensis culture in 78% of the animals. The antigen proved to be effective only at the remote period between the revaccination and the primary antigen vaccination (12 months). The data obtained pointed to a high protective action of the antigen in the guinea pig revaccination 9 to 12 months after their immunization with live brucella Br. abortus 19-BA vaccine.
D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D000942:Antigens, Bacterial; D002002:Brucella / Q000276:immunology; D002004:Brucella Vaccine / Q000008:administration & dosage*; D002003:Brucella abortus; D002006:Brucellosis / Q000517:prevention & control*; D006168:Guinea Pigs; D007117:Immunization, Secondary; D013997:Time Factors; D014611:Vaccination
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D002004:Brucella Vaccine
Izuchenie immunogennykh svoĭstv brutselleznogo protektivnogo antigena pri revaktsinatsii