Estradiol receptors and glucose-6-phosphate dehydrogenase activity in human breast tumors.
Estradiol receptors and glucose-6-phosphate dehydrogenase, an enzyme induced by estrogens, were measured in both benign and malignant human breast tumors. The mean glucose-6-phosphate dehydrogenase activity was higher in the malignant tumors than in the benign tumors. Tumors containing estradiol receptors contained higher activities of glucose-6-phosphate dehydrogenase than tumors without receptors. In breast carcinomas with and without estradiol receptors glucose-6-phosphate dehydrogenase gave 3 isoenzymes with very similar electrophoretic pattern after polyacrylamide gel electrophoresis. The results showed that although glucose-6-phosphate dehydrogenase was higher in estradiol receptor positive than in estradiol receptor negative tumors there was no significant correlation between the estradiol receptor concentration and glucose-6-phosphate dehydrogenase activity in human breast tumors.
D001943:Breast Neoplasms / Q000201:enzymology / Q000378:metabolism*; D004273:DNA, Neoplasm / Q000032:analysis; D004958:Estradiol / Q000378:metabolism*; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000302:isolation & purification / Q000378:metabolism*; D006801:Humans; D007527:Isoenzymes / Q000302:isolation & purification; D009363:Neoplasm Proteins / Q000032:analysis; D011960:Receptors, Estrogen / Q000378:metabolism*
D004273:DNA, Neoplasm; D007527:Isoenzymes; D009363:Neoplasm Proteins; D011960:Receptors, Estrogen; D004958:Estradiol; D005954:Glucosephosphate Dehydrogenase