title: Comparison of lung cancer and amyloidosis in rabbits induced by chemical carcinogens.
abstract: For the purpose of inducing experimental lung cancer, carcinogens were applied into the bronchus of the rabbit. Experiments were divided into 2 groups, I and II, depending on the methods of application of chemical carcinogens into the bronchus. In Experiment I, carcinogens (4-nitroquinoline 1-oxide and/or 3-methylcholanthrene) in rabbit plasma or distilled water were instilled in the lower bronchus and, in Experiment II, 3-methylcholanthrene in Tween 60 was swabbed on the maon bronchus through a specially made bronchoscope. (1) In Experiment I, 163 of 366 rabbits having received over 4 instillations of the chemical carcinogens and surviving for more than 30 days developed lung cancer. However, in Experiment II, only 2 of 65 rabbits surviving more than 60 days developed lung cancer. (2) In Experiment II, 39 (60%) of 65 rabbits were found to have developed amyloidosis. However, in Experiment I, 86 (approx. 23%) of 366 rabbits developed amyloidosis. Amyloidosis was observed to occur in the kidneys, spleen, liver, and adrenals in both experiments.
mesh_terms: D015112:4-Nitroquinoline-1-oxide / Q000008:administration & dosage*; D000686:Amyloidosis / Q000139:chemically induced* / Q000473:pathology; D000818:Animals; D001980:Bronchi; D002273:Carcinogens / Q000008:administration & dosage; D005260:Female; D008113:Liver Neoplasms / Q000473:pathology; D008175:Lung Neoplasms / Q000139:chemically induced*; D008297:Male; D008748:Methylcholanthrene / Q000008:administration & dosage*; D009600:Nitroquinolines / Q000008:administration & dosage*; D011136:Polysorbates / Q000008:administration & dosage; D011817:Rabbits
chemical_list: D002273:Carcinogens; D009600:Nitroquinolines; D011136:Polysorbates; D008748:Methylcholanthrene; D015112:4-Nitroquinoline-1-oxide