Reserpine induced supersensitivity to isoprenaline on the blood pressure and heart rate of anaesthetized rabbits.
Reserpine, when administered intraperitoneally in 0.25, 0.5 and 1 mg/kg doses, produced a decrease in the mean blood pressure and heart rate of the pentobarbitone anaesthetized rabbits. In these animals reserpine pretreatment produced supersensitivity to the hypotensive and positive chronotropic effects of isoprenaline.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004347:Drug Interactions; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D007545:Isoproterenol / Q000494:pharmacology*; D008297:Male; D011817:Rabbits; D012110:Reserpine / Q000008:administration & dosage / Q000494:pharmacology*
D012110:Reserpine; D007545:Isoproterenol