title: Effect of halothane and halothane-nitrous oxide on hematocrit and plasma protein concentration in dog and monkey.
abstract: Hematocrit and plasma protein concentration in healthy dogs and monkeys (Macaca arctoides) awake and anesthetized with halothane-oxygen and halothane-nitrous oxide oxygen were compared during conditions of spontaneous and controlled ventilation. Both hematocrit and plasma protein concentration decreased within 15 minutes following anesthetic induction. This decrease persisted throughout constant- or variable-depth anesthesia and did not vary appreciably with ventilation, anesthetic dose, or introduction of nitrous oxide. Plasma volume, determined by a dye dilution technique, concomitantly increased. This increase is compatible with the directional changes in hematocrit and plasma protein.
mesh_terms: D000769:Anesthesia, Inhalation / Q000662:veterinary*; D000818:Animals; D001798:Blood Proteins / Q000032:analysis*; D004285:Dogs / Q000097:blood*; D004912:Erythrocytes / Q000187:drug effects; D005260:Female; D006221:Halothane / Q000494:pharmacology*; D000882:Haplorhini; D006400:Hematocrit; D008251:Macaca / Q000097:blood*; D008297:Male; D009609:Nitrous Oxide / Q000494:pharmacology*; D010953:Plasma Volume / Q000187:drug effects
chemical_list: D001798:Blood Proteins; D009609:Nitrous Oxide; D006221:Halothane