title: Purification of a plasminogen activator inhibitor indistinguishable from alpha1-antitrypsin and an urokinase inhibitor in pregnancy plasma.
abstract: An inhibitor of urokinase present in increased concentrations in plasma during pregnancy was purified. The inhibitor was identified by its pronounced effect on urokinase-induced fibrinolysis as opposed to the absence of effect on fibrinolysis induced by a tissue plasminogen activator. The inhibitor progressively inactivated urokinase upon incubation and was found to be indistinguishable from alpha1-antitrypsin.
mesh_terms: D000991:Antithrombins / Q000302:isolation & purification; D005591:Chemical Fractionation; D002850:Chromatography, Gel; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects; D006801:Humans; D008297:Male; D010949:Plasma / Q000032:analysis*; D010960:Plasminogen Activators / Q000037:antagonists & inhibitors*; D015849:Plasminogen Inactivators; D011247:Pregnancy; D011480:Protease Inhibitors; D014568:Urokinase-Type Plasminogen Activator / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D000515:alpha 1-Antitrypsin / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000991:Antithrombins; D015849:Plasminogen Inactivators; D011480:Protease Inhibitors; D000515:alpha 1-Antitrypsin; D010960:Plasminogen Activators; D014568:Urokinase-Type Plasminogen Activator