[Effect of erythrocytes on fibrinolysis].
The effect of destroyed and washed intact erythrocytes of normal subjects and patients with various haematological diseases was studied on the fibrinolytic activity of whole blood and plasma. Intact erythrocytes of normal and sick subjects inhibited dissolution of the clot; haemolyzed erythrocytes accelerated lysis of the euglobulin clot. Studies on fibrin films revealed in the erythrocytes of normal subjects the presence of a plasminogen activator in the fluid fraction and an inhibitor of activation in the stroma. Correlation analysis allowed to establish connections between the number of erythrocytes and the fibrinolytic activity of blood. The erythrocytes thus are affecting the process of fibrinolysis.
D004906:Erythrocyte Count; D004912:Erythrocytes / Q000378:metabolism*; D005342:Fibrinolysis; D006461:Hemolysis; D006801:Humans; D010960:Plasminogen Activators / Q000037:antagonists & inhibitors / Q000097:blood; D015849:Plasminogen Inactivators
D015849:Plasminogen Inactivators; D010960:Plasminogen Activators