Effect of atropine and methiamide on vagally induced gastric acid secretion and gastrin release in anesthetized cats.
Gastrin release and HCl secretion was induced by electrical vagal stimulation in anesthetized cats. Both atropine (0.1-0.3 mg/kg) and methiamide (4-20 mg/kg) inhibited the HCl secretion (by approximately 60 and approximately 80 %). On the other hand, neither atropine (0.2-2 mg/kg) nor methiamide (20 mg/kg) inhibited the vagally induced gastrin release. Possible explanations of the atropine resistance of the vagal gastrin release mechanism are discussed.
D000768:Anesthesia, General; D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D002415:Cats; D004558:Electric Stimulation; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D005755:Gastrins / Q000378:metabolism*; D008785:Metiamide / Q000494:pharmacology*; D012636:Secretory Rate / Q000187:drug effects; D013890:Thiourea / Q000031:analogs & derivatives*; D013997:Time Factors; D014630:Vagus Nerve / Q000502:physiology
D005755:Gastrins; D008785:Metiamide; D001285:Atropine; D013890:Thiourea