Location of the site of bacterial bile-salt deconjugation by combining abdominal scintigraphy with expired C-14.
A combined 14CO2 bile-salt breath and scintigraphic test has proved useful in determining the site of bile-salt deconjugation by bacteria. Data suggest that the procedure can be shortened to less than 8 hr with Tc-99m sulfur colloid abdominal scintigrams added to locate the labeled meal. Moreover the cumulative 14CO2 excretion, which is an indes of the rate of bile-salt deconjugation, gives clearer separation than peak specific activity between normals and either high or low deviations from normal, The test should be helpful in a number of difficult diagnostic problems involving chronic diarrhea, and offers as well both as well both a guide to appropriate therapy and a monitor for relapse in enfected blind-loop syndromes,
D001647:Bile Acids and Salts / Q000378:metabolism*; D001944:Breath Tests / Q000379:methods*; D002250:Carbon Radioisotopes; D002793:Cholic Acids; D003082:Colectomy; D003106:Colon / Q000382:microbiology*; D006000:Glycocholic Acid; D006801:Humans; D007081:Ileostomy; D007410:Intestinal Diseases / Q000175:diagnosis*; D007421:Intestine, Small / Q000382:microbiology* / Q000601:surgery; D008286:Malabsorption Syndromes / Q000175:diagnosis; D011178:Postgastrectomy Syndromes / Q000175:diagnosis; D011877:Radionuclide Imaging / Q000379:methods*; D013667:Technetium
D001647:Bile Acids and Salts; D002250:Carbon Radioisotopes; D002793:Cholic Acids; D013667:Technetium; D006000:Glycocholic Acid