title: Metergoline as a selective 5-hydroxytryptamine antagonist in the cerebral cortex.
abstract: In rats anaesthetized with a mixture of methoxyflurane, nitrous oxide, and oxygen, the depressant actions on the cerebral cortical neurones of iotophoretically applied 5-hydroxytryptamine (5-HT) but not of noradrenaline, histamine, AMP Ca2+, and gamma-aminobutyric acid were antagonized by metergoline. These observations indicate that metergoline may be a selective 5-HT antagonist in the cerebral cortex.
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000249:Adenosine Monophosphate / Q000494:pharmacology; D000818:Animals; D002540:Cerebral Cortex / Q000166:cytology / Q000187:drug effects*; D003864:Depression, Chemical; D004873:Ergolines / Q000494:pharmacology*; D006632:Histamine / Q000494:pharmacology; D008297:Male; D008711:Metergoline / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000494:pharmacology; D012702:Serotonin Antagonists; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
chemical_list: D004873:Ergolines; D012702:Serotonin Antagonists; D008711:Metergoline; D012701:Serotonin; D000249:Adenosine Monophosphate; D005680:gamma-Aminobutyric Acid; D006632:Histamine; D009638:Norepinephrine