Cocarcinogenic effects of n-alkanes and ultraviolet light on mice.
A comparison was made of the effects of repeated topical applications to mice of three n-paraffins (n-decane), n-dodecane, and n-tetradecane) on the carcinogenic potential of UV light at three wavelength regions: 254 nm, 290-320 nm, and greater than 350 nm. All three n-alkanes had a cocarcinogenic effect at 254 nm, whereas only n-dodecane was effective from 290 to 320 nm. Radiation at wavelengths longer than 350 nm, generally considered noncarcinogenic, produced tumors on the backs of mice treated with n-decane or n-tetradecane.
D000473:Alkanes / Q000633:toxicity*; D000818:Animals; D003043:Cocarcinogenesis; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009374:Neoplasms, Experimental / Q000209:etiology; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D012878:Skin Neoplasms / Q000209:etiology*; D014466:Ultraviolet Rays / Q000009:adverse effects*
D000473:Alkanes