Harmine action in rats with lymphostatic encephalopathy.
In rats with lymphostatic encephalopathy the duration of harmine tremor was lengthened, and the brain concentrations of harmine decreased more slowly than in sham-operated controls. The tremor began simultaneously in both rat groups at coinciding brain concentrations of harmine. In rats with lymphostatic encephalopathy harmine concentrations in brain at the termination of tremor lay in the same range as in sham-operated controls. The plasma concentrations of harmine were not changed by the disease. It is concluded that during lymphostatic encephalopathy the lymphatic drug elimination from brain is impaired whereas--at least for harmine--the blood-brain barrier functions as normal.
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D001812:Blood-Brain Barrier; D001921:Brain / Q000378:metabolism*; D001927:Brain Diseases / Q000503:physiopathology*; D006247:Harmine / Q000494:pharmacology*; D008208:Lymphatic System / Q000503:physiopathology; D008297:Male; D051381:Rats; D014202:Tremor / Q000139:chemically induced
D000470:Alkaloids; D006247:Harmine