Quantitative studies in vitro on uptake and esterification of palmitate into human and rat jejunal mucosa.
Quantitative incorporation and esterification of (9-10) 3H palmitate into jejunal mucosa was studied in vitro comparatively on human biopsies and on everted rings of rat intestine following various incubation times. This procedure is fitted for investigation of the glycophosphate pathway. Quantitatively the total uptake of palmitate was similar in man and rat. But the distribution among the various esterified fractions was different in animal and man and different again in coeliac disease. Notwithstanding incorporation of palmitate into triglyceride the fatty acid composition of mucosal triglyceride showed little or no modification.
D000818:Animals; D002788:Cholesterol Esters / Q000378:metabolism; D003108:Colonic Diseases / Q000378:metabolism; D004075:Diglycerides / Q000378:metabolism; D004951:Esterification; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism*; D007583:Jejunum / Q000378:metabolism*; D008297:Male; D009829:Oleic Acids / Q000494:pharmacology; D010168:Palmitates / Q000378:metabolism*; D010169:Palmitic Acids / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D013997:Time Factors; D014280:Triglycerides / Q000378:metabolism
D002788:Cholesterol Esters; D004075:Diglycerides; D005230:Fatty Acids, Nonesterified; D009829:Oleic Acids; D010168:Palmitates; D010169:Palmitic Acids; D010743:Phospholipids; D014280:Triglycerides