Cytogenetic investigations on mice treated with lead.
Dietary lead at different dose levels was given to female C57B1 mice for periods up to 3 months. No severe chromosome or chromatid aberrations were observed at any dose level and the frequency of chromatid gaps increased significantly only at the highest doses. (0.5 and 1% of lead in the diet). The number of micronuclei in polychromatic erythrocytes also remained at control levels after lead treatment, whereas known mutagenic agent such as Myleran and Mitomycine C raised their incidence markedly. Taking into account also the data in the literature, it is concluded that lead per se probably has no mutagenic action on mammals.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000648:ultrastructure; D001854:Bone Marrow Cells; D002869:Chromosome Aberrations; D004032:Diet; D004912:Erythrocytes / Q000187:drug effects / Q000648:ultrastructure; D005260:Female; D007854:Lead / Q000633:toxicity*; D051379:Mice; D008810:Mice, Inbred C57BL; D009153:Mutagens; D013997:Time Factors
D009153:Mutagens; D007854:Lead