Survival of pleomorphic sarcoma-37 transplanted virgin female DBA/2J mice: hyperthermia and hyperglycemia, alone and in combination with drugs.
Sarcoma-37 (S-37) transplanted DBA/2J mice were submitted to a controlled whole body hyperglycemic-hyperthermic ("double attack") treatment. A single exposure to the 3-hr 400-500-mg% blood glucose level coupled with 1 hr of whole body 40.0 degrees warming was safe and extended longevity by 40% over the nontreated controls. This increase suggests that additive or potentiated effects follow the two-parameter procedure. The treatment safety and resultant increased longevity were not enhanced by single-dose chemotherapy with doxorubicin and/or dacarbazine.
D000818:Animals; D001786:Blood Glucose / Q000502:physiology*; D005260:Female; D005947:Glucose / Q000627:therapeutic use; D006358:Hot Temperature; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D009368:Neoplasm Transplantation; D012511:Sarcoma 37 / Q000188:drug therapy / Q000628:therapy*; D012737:Sex Factors; D014184:Transplantation, Homologous
D001786:Blood Glucose; D005947:Glucose