title: Reversal of the toxicity of hydrazine an analogues by pyridoxine hydrochloride.
abstract: Single subcutaneous injections of each of five substituted hydrazines were given alone and jointly with pyridoxine hydrochloride (PH) to Swiss mice. The convulsive, toxic, and lethal effects of four compounds--methylhydrazine (MH), ethylhydrazine hydrochloride (EH), n-butylhydrazine hydrochloride (BH), and beta-N-[gamma-L(+)-glutamyl]-4-hydroxymethylphenylhydrazine--were successfully prevented by administering PH before and/or after injection. The toxic symptoms caused by N-methyl-N-formylhydrazine (MFH) were, however, only slightly inhibited by this vitamin.
mesh_terms: D000818:Animals; D005260:Female; D006834:Hydrazines / Q000037:antagonists & inhibitors / Q000633:toxicity*; D008297:Male; D051379:Mice; D011736:Pyridoxine / Q000494:pharmacology*; D012640:Seizures / Q000139:chemically induced
chemical_list: D006834:Hydrazines; D011736:Pyridoxine