Effect of prolonged administration of gastrin on experimental carcinogenesis in rat stomach induced by N-methyl-N' -nitro-N-nitrosoguanidine.
The effects of gastrin on gastric acid secretion and on the incidence of gastric carcinoma induced by N-methyl-N'-nitro-N-nitrosoquanidine were investigated in rats. At Week 50 after the start of the experiment, it was found that prolonged administration of gastrin after treatment with N-methyl-N'-nitro-N-nitrosoquanidine resulted in a significant increase in gastric acid secretion and a significant reduction in the incidence of adenocarcinomas of the glandular stomach. The administration of gastrin did not influence the histological appearance of the few gastric adenocarcinomas that did develop.
D000230:Adenocarcinoma / Q000139:chemically induced* / Q000188:drug therapy; D000818:Animals; D004334:Drug Administration Schedule; D005750:Gastric Juice / Q000187:drug effects / Q000378:metabolism; D005755:Gastrins / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D008769:Methylnitronitrosoguanidine; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy; D051381:Rats; D013274:Stomach Neoplasms / Q000139:chemically induced* / Q000188:drug therapy
D005755:Gastrins; D008769:Methylnitronitrosoguanidine