Increased potassium permeability induced in vitro by menadione in normal human red cells.
Normal red blood cells, preincubated for 75 min with 1.15 mM menadione sodium bisulfite lose potassium and water on subsequent incubation at 37 degrees C for 24 h without menadione. The potassium loss is increased by addition of calcium and prevented by addition of glucose. Since normal red cells treated with menadione behave like untreated hypochromic cells, both from beta-thalassaemia or iron deficiency anaemia in respect to membrane permeability to potassium, it may be supposed that menadione induces in normal red cells an abnormality similar to that naturally occurring in hypochromic cells.
D002118:Calcium / Q000494:pharmacology; D002463:Cell Membrane Permeability / Q000187:drug effects*; D004910:Erythrocyte Membrane / Q000032:analysis / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism*; D005947:Glucose / Q000494:pharmacology; D006801:Humans; D011188:Potassium / Q000378:metabolism*; D012964:Sodium / Q000032:analysis / Q000378:metabolism; D014812:Vitamin K / Q000494:pharmacology*; D014867:Water / Q000378:metabolism
D014867:Water; D014812:Vitamin K; D012964:Sodium; D005947:Glucose; D011188:Potassium; D002118:Calcium