The association of HLA-B7 and HLA-B12 antigens with cup/disk ratio, family history of glaucoma, and intraocular pressure.
The presence of either HLA-B7 or HLA-B12 antigens was associated with a higher prevalence of cup/disk ratios greater than 0.3 in the GG responders (intraocular pressure greater than 31 mm Hg after six weeks of topical dexamethasone 0.1%, four times daily) and in the combined NN-NG (intraocular pressure less than or equal to 31 mm Hg) groups. The presence of either antigen was associated with a higher prevalence of a family history of glaucoma in the GG group. N association was noted between the antigens and age, sex, race, or mean intraocular pressure in either of the groups studied.
D003907:Dexamethasone / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D005901:Glaucoma / Q000235:genetics* / Q000276:immunology; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D009898:Optic Disk
D006680:HLA Antigens; D006649:Histocompatibility Antigens; D009883:Ophthalmic Solutions; D003907:Dexamethasone