Effects of ionenes on interferon induction by poly(inosinic acid) . poly(cytidylic acid).
Depending on the spacing of their positive charges, ionenes, a class of quaternary ammonium polymers, increased the interferon-inducing activity of poly(inosinic acid).poly(cytidylic acid) in mouse L-929 cells, whereas they did not enhance poly(inosinic acid).poly(cytidylic acid) induced interferon production in primary rabbit kidney and human skin fibrolast cells.
D002460:Cell Line; D007372:Interferons / Q000096:biosynthesis*; D007739:L Cells / Q000187:drug effects / Q000378:metabolism; D046911:Macromolecular Substances; D011070:Poly I-C / Q000494:pharmacology*; D011073:Polyamines / Q000494:pharmacology*; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology
D046911:Macromolecular Substances; D011073:Polyamines; D000644:Quaternary Ammonium Compounds; D007372:Interferons; D011070:Poly I-C