title: Alpha-and- beta-activity of O-methylated derivatives of norepinephrine and epinephrine.
abstract: Metanephrine, iso-metanephrine, normetanephrine and isonormetaephrine were tested for alpha- and beta-activity on various tissues obtained from rats, guinea-pigs and cats. It was found that methylation of the hydroxyl groups of norepinephrine or epinephrine in either the 3- or 4-position markedly reduces or abolishes alpha- and beta-activity with the exception of the nictitating membrane of the cat. This receptor seems to show a tissue difference.
mesh_terms: D000818:Animals; D002415:Cats; D004837:Epinephrine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects / Q000502:physiology; D008297:Male; D009541:Nictitating Membrane / Q000187:drug effects / Q000502:physiology; D009638:Norepinephrine / Q000031:analogs & derivatives* / Q000494:pharmacology; D009928:Organ Specificity; D051381:Rats; D013154:Spleen / Q000187:drug effects / Q000502:physiology; D013329:Structure-Activity Relationship; D014649:Vas Deferens / Q000187:drug effects / Q000502:physiology
chemical_list: D009638:Norepinephrine; D004837:Epinephrine