Myocardial response to contrast media: effects on electrolyte metabolism and subcellular structures.
The success of coronary angiography depends upon appropriate use and administration of contrast media. We used guinea-pig hearts to study tolerance to various contrast media, with particular attention to electrolyte changes. Changes in myocardial subcellular structures appear to correspond to changes in electrolyte flow produced by contrast media.
D000818:Animals; D002118:Calcium / Q000378:metabolism; D003287:Contrast Media / Q000009:adverse effects*; D003973:Diatrizoate / Q000009:adverse effects; D005110:Extracellular Space / Q000378:metabolism; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D007483:Iothalamic Acid / Q000009:adverse effects; D009206:Myocardium / Q000378:metabolism* / Q000648:ultrastructure; D011188:Potassium / Q000378:metabolism; D012964:Sodium / Q000378:metabolism
D003287:Contrast Media; D003973:Diatrizoate; D007483:Iothalamic Acid; D012964:Sodium; D011188:Potassium; D002118:Calcium