[Pseudohypoaldsteronism. A further case report (author's transl)].
The clinical symptomatology and diagnostic procedures of pseudohypoaldosteronism in an 8 days old male newborn infant are described. The course of the disease was initially characterized by failure to thrive, renal salt loss, hyponatremia and hyperkalemia. Daily treatment with 3 g sodium chloride improved symptoms. Hydrocortisone and desoxycortiscosteronacetate were without any effect. Urinary aldosterone excretion was increased 10 to 20 times of normal. 17 ketosteroid and pregananetriol were normal. The infant died of ulcerative enterocolitis at the age of 1 1/2 years. Beside the first description of the disease by Cheek et al. (1958) 13 further publications have been collected from the literature. Symptoms at the beginning, sex, serum electrolytes, aldosterone excretion, somatic development, observation period, treatment and duration of therapy are compared with the presented case report.
D015068:17-Ketosteroids / Q000652:urine; D000312:Adrenal Hyperplasia, Congenital / Q000175:diagnosis* / Q000188:drug therapy / Q000652:urine; D000450:Aldosterone / Q000172:deficiency* / Q000652:urine; D003937:Diagnosis, Differential; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011279:Pregnanetriol / Q000652:urine; D012965:Sodium Chloride / Q000627:therapeutic use
D015068:17-Ketosteroids; D011279:Pregnanetriol; D012965:Sodium Chloride; D000450:Aldosterone; D006854:Hydrocortisone
Der Pseudohypoaldosteronismus. Bericht eines weiteren Falles