Studies with an artificial endocrine pancreas.
Short-term studies with an artificial endocrine pancreas have provided insights into the pathophysiology of diabetes and demonstrated the ability of such a system to restore and maintain glucose homeostasis in human subjects given either their usual diet, a 50 gm oral glucose tolerance test, or a moderate level of physical exercise. Animals were used to demonstrate that a peripheral route of insulin delivery by the artificial pancreas is equivalent to the portal route.
D000818:Animals; D001187:Artificial Organs; D001786:Blood Glucose / Q000378:metabolism; D003920:Diabetes Mellitus / Q000503:physiopathology*; D004195:Disease Models, Animal; D004285:Dogs; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005934:Glucagon / Q000378:metabolism; D005951:Glucose Tolerance Test / Q000379:methods; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000008:administration & dosage; D010179:Pancreas / Q000503:physiopathology*; D005082:Physical Exertion
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D005934:Glucagon