Platelet thrombopathy in asthmatic patients with elevated immunoglobulin e.
Abnormalities of second-wave platelet aggregation were demonstrated in 17 of 33 asthmatic patients in whom drug and diet intake were controlled in the hospital. Mean abnormal responses were significantly greater after epinephrine- (p less than 0.001), adenosine diphosphate-(less than 0.001), collagen- (p = 0.01), and thrombin- (p less than 0.001) induced platelet aggregation in patients with immunologically mediated asthma and serum IgE levels greater than 250 U/ml as compared to patients without immunologic factors and/or normal controls. Mean pollen-specific radioallergosorbent (RAST) binding was also significantly higher in patients with abnormal aggregation as compared to normal platelet responders (p = 0.02). Release of serotonin generally reflected abnormal aggregation patterns in asthmatic patients. Platelet factor 4 release was significantly decreased in the same groups of patients. These results suggest that the allergic state may affect platelet membrane responsiveness to multiple aggregating agents.
D000244:Adenosine Diphosphate; D000293:Adolescent; D000328:Adult; D000368:Aged; D000628:Aminophylline / Q000097:blood; D001249:Asthma / Q000097:blood* / Q000276:immunology; D002395:Catecholamines / Q000652:urine; D003094:Collagen; D004837:Epinephrine; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007073:Immunoglobulin E / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects; D010978:Platelet Factor 4 / Q000032:analysis; D011852:Radioallergosorbent Test; D012129:Respiratory Function Tests; D012701:Serotonin / Q000378:metabolism; D012882:Skin Tests; D013917:Thrombin
D002395:Catecholamines; D000628:Aminophylline; D012701:Serotonin; D010978:Platelet Factor 4; D007073:Immunoglobulin E; D000244:Adenosine Diphosphate; D003094:Collagen; D013917:Thrombin; D006854:Hydrocortisone; D004837:Epinephrine