Activation of the classical complement pathway by Fc fragment of human IgA.
Intact Fcalpha fragments from five human IgA myeloma proteins were produced by two different methods, high temperature trypsinolysis and IgA protease digestion. Three of the Fcalpha fragments activated the classical pathway as determined by the titers of the individual complement components. Two other fragments did not fix complement by either pathway.
D003165:Complement System Proteins / Q000378:metabolism*; D006801:Humans; D007070:Immunoglobulin A / Q000494:pharmacology; D007141:Immunoglobulin Fc Fragments / Q000494:pharmacology; D010447:Peptide Hydrolases / Q000494:pharmacology; D013696:Temperature; D014357:Trypsin / Q000494:pharmacology
D007070:Immunoglobulin A; D007141:Immunoglobulin Fc Fragments; D003165:Complement System Proteins; D010447:Peptide Hydrolases; D014357:Trypsin