Probability of establishing chimeric plasmids in natural populations of bacteria.
Formulas for estimating the probability that chimeric plasmids carried by disarmed hosts will become established in natural populations of bacteria are presented and their use illustrated with a series of realistic numerical examples. The implications of these a priori probability estimates for the problem of containment for recombinant DNA research is discussed.
D003227:Conjugation, Genetic; D004269:DNA, Bacterial / Q000378:metabolism*; D004274:DNA, Recombinant / Q000378:metabolism*; D005111:Extrachromosomal Inheritance; D008954:Models, Biological; D010957:Plasmids; D011157:Population Dynamics; D012107:Research Design / Q000592:standards
D004269:DNA, Bacterial; D004274:DNA, Recombinant