Vitamin E deficiency and enhanced platelet function: reversal following E supplementation.
Marked platelet hyperaggregability to adenosine diphosphate, epinephrine, and collagen was demonstrated in two children with vitamin E deficiency, with complete reversal following E supplementation. No clinical thrombotic tendency was observed during the E-deficient state. The action of vitamin E in the schema of platelet arachidonate peroxidation appears to be at the step of phosphilpase A activation, or the conversion of arachidonic acid into the cyclic endoperoxides, since the peroxidation product malonaldehyde was increased during the E-deficient state with normalization following E sufficiency.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D001095:Arachidonic Acids / Q000378:metabolism; D001792:Blood Platelets / Q000503:physiopathology; D003094:Collagen / Q000494:pharmacology; D004789:Enzyme Activation / Q000187:drug effects; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D006801:Humans; D007223:Infant; D010740:Phospholipases / Q000378:metabolism; D010974:Platelet Aggregation / Q000187:drug effects; D014808:Vitamin D Deficiency / Q000097:blood* / Q000188:drug therapy; D014810:Vitamin E / Q000494:pharmacology / Q000627:therapeutic use*
D001095:Arachidonic Acids; D014810:Vitamin E; D000244:Adenosine Diphosphate; D003094:Collagen; D010740:Phospholipases; D004837:Epinephrine