Treatment of acute and subacute gonococcal urethritis with fosfomycin.
70 patients, 69 male and 1 female, 23 suffering from subacute gonococcal urethritis and the other 47 suffering from acute gonococcal urethritis, have been treated with fosfomycin with the intramuscular method. The treatment was planned as follows: (1) in 12 patients a total dose of 4 g (2g/4h) was tried with 11 bacteriological and clinical cures (92%) and 1 failure; (2) in another 43 patients a single dose of 4 g was tried (2 g in each buttock), with 37 cures (86%) and 6 failures; (3) finally, in another group of 15 patients with subacute gonococcal urethritis, fosfomycin was administered at the rate of 2g/8h for 2 days, clinical and bacteriological cures being achieved in all patients (100%). The failures, a total of 7, are patients with subacute gonococcal urethritis who were given a single dose of 4 g.
D000208:Acute Disease; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D004341:Drug Evaluation; D005260:Female; D005578:Fosfomycin / Q000008:administration & dosage / Q000627:therapeutic use*; D006069:Gonorrhea / Q000188:drug therapy*; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D012008:Recurrence
D000900:Anti-Bacterial Agents; D005578:Fosfomycin