Kinetics of antibody mediated suppression of humoral immune response to Toxoplasma gondii at a cellular level.
The effect of passively transferred Toxoplasma gondii antiserum was examined at a cellular level by rosette forming cell response in NMRI mouse spleen. The initial number of responding rosette forming cells was decreased in antibody treated animals; However, their rate of proliferation in comparison to untreated group was not significantly affected. Almost similar response could be obtained by injecting low 5 x 10(4) Toxoplasma dose alone or a combination of passive antibody and higher antigen dose of 1 x 10(6) parasites.
D000818:Animals; D005260:Female; D007104:Immune Adherence Reaction; D007116:Immunization, Passive; D007165:Immunosuppression Therapy; D051379:Mice; D014123:Toxoplasmosis / Q000276:immunology*