[Effect of phepracet and its derivatives on the development of neurogenic dystrophy of the stomach wall and the concentration of noradrenaline in it].
The "weighted" phenamine derivatives--phepracet (beta-phenyl isopropylamide of paraaminophenylacetic acid) and preparations IZM-611 ((phenylisopropylamide of paradipropylaminophenylacetic acid) and IZM-487 (phenylisopropylamide of paradietylaminophenylacetic acid) positively prevented the development of hemorrhagic erosions in the gastric wall and forced down the nerepinephrine level in it caused by a 3-hour electric stimulation of immobilized rats. The greatest prophylactic effect produced the preparation IZM-611. A direct relation between intensity of the antiulcerous action of the drugs and their ability to block the reticular formations of the midbrain was noted.
D000661:Amphetamine / Q000627:therapeutic use; D000662:Amphetamines / Q000627:therapeutic use*; D000818:Animals; D004558:Electric Stimulation; D008297:Male; D051381:Rats; D012149:Restraint, Physical; D013272:Stomach Diseases / Q000209:etiology / Q000517:prevention & control*
D000662:Amphetamines; D000661:Amphetamine
Vliianie fepratseta i ego proizvodnykh na vozniknovenie neĭrogennoĭ distrofii stenki zheludka i soderzhanie v neĭ noradrenalina