Thermal tolerance and repair of thermal damage by cultured cells.
Exposure of hamster cells to 42.5 degrees C for long periods leads to the development of thermal tolerance; the slope of the survival curve become shallower after about 3.5 to 4 hours. If two 4-hour exposures at 42.5 degrees C are separated by various periods of time, thermal tolerance is eliminated by 20 hours. Prolonged exposure at 42.5 degrees C offers considerable protection from subsequent treatments to acute hyperthermia at 45 degrees C indicate or in conditioned medium or balanced salt solution failed to reveal any evidence of repair of potentially lethal damage.
D000818:Animals; D002455:Cell Division; D002460:Cell Line; D002478:Cells, Cultured / Q000528:radiation effects; D006224:Cricetinae; D006358:Hot Temperature; D006979:Hyperthermia, Induced; D066298:In Vitro Techniques; D007700:Kinetics; D009374:Neoplasms, Experimental / Q000473:pathology / Q000532:radiotherapy / Q000628:therapy*; D011833:Radiation Injuries, Experimental