Effect of methysergide and pimozide on apomorphine-induced growth hormone secretion in men.
The dopamine receptor agonist, apomorphine HCl (0.75 mg sc) increased serum growth hormone (GH) concentrations in each of 6 subjects. This increase was not inhibited by pretreatment with the serotonin antagonist, methysergide, but was completely abolished in the 4 individuals pretreated with pimozide, a selective dopamine receptor blocking agent. These results provide further evidence that apomorphine-induced GH secretion is mediated by a dopaminergic mechanism and is independent of a serotonergic mechanism.
D001058:Apomorphine; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D008297:Male; D008784:Methysergide / Q000494:pharmacology*; D010868:Pimozide / Q000494:pharmacology*; D011388:Prolactin / Q000097:blood
D010868:Pimozide; D011388:Prolactin; D013006:Growth Hormone; D001058:Apomorphine; D008784:Methysergide