[The efficacy of mebendazole and praziquantel on larval taeniids from mouse, rabbit and pig (author's transl)].
The efficacy of Mebendazole (Janssen) and Praziquantel (Bayer) on Cysticercus fasciolaris, C. tenuicollis resp. C. pisiformis was studied in 125 mice, 63 pigs and 30 rabbits. All mice were infected naturally with C. fasciolaris. The pigs were infected experimentally with 2000 resp. 5000 eggs of Taenia hydatigena and the rabbits with 1500 eggs of Taenia pisiformis. 8 weeks p.i. animals were divided into groups and received 25 mg/kg Mebendazole or 50 mg/kg Praziquantel on 5 consecutive days as well as 5 mg/kg Mebandazole resp. 10 mg/kg praziquantel for 14 days. The applied doses of 62.5 and 12.5 mg/kg Mebendazole to mice for 10 days or 14 days showed almost no efficacy against C. fasciolaris whereas 250 and 125 mg/kg Praziquantel given for 10 days gave 100% good results. We found that Mebendazole is highly efficient only against C. tenuicollis at a concentration of 25 mg/kg in the pig, whereas in the rabbit the 5 mg dose over 14 days still revealed good results. Praziquantel showed a virtually 100% success using 50 mg/kg for 5 days and 10 mg/kg for 14 days, whereas the efficacy of Praziquantel against C. pisiformis in rabbits administering the same dose was not satisfying.
D000818:Animals; D001562:Benzimidazoles / Q000627:therapeutic use*; D003551:Cysticercosis / Q000188:drug therapy*; D007546:Isoquinolines / Q000627:therapeutic use*; D008463:Mebendazole / Q000627:therapeutic use*; D051379:Mice; D011719:Pyrazines / Q000627:therapeutic use*; D011817:Rabbits; D013552:Swine
D001562:Benzimidazoles; D007546:Isoquinolines; D011719:Pyrazines; D008463:Mebendazole
Die Wirkung von Mebendazole und Praziquantel auf larvale Taenienstadien bei Maus, Kaninchen und Schwein