In vitro metabolism of a new 4-hydroxycoumarin anticoagulant. Structure of an unusual metabolite.
The metabolism of clocoumarol, 3-[1-[P-(2-chlorethyl)phenyl]butyl]-4-hydroxycoumarin, by rat liver microsomes was investigated. The chemical structure of the main metabolite is 6-[1-hydroxy-2-oxo-3-[p-(2-chloro
D015110:4-Hydroxycoumarins / Q000378:metabolism*; D000818:Animals; D001711:Biotransformation; D055598:Chemical Phenomena; D002621:Chemistry; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008862:Microsomes, Liver / Q000378:metabolism*; D051381:Rats
D015110:4-Hydroxycoumarins; C006046:clocoumarol