title: Leakage of cellular material from Thiobacillus ferrooxidans in the presence of organic acids.
abstract: Thiobacillus ferroodixans cells released varying amounts of iron, phosphate, sugar, ribonucleic acid, deoxyribonucleic acid, and substances that absorbed light at both 260 and 280 nm, when exposed to 10(-2) to 10(-1) M concentrations of these organic acids: propionic, butyric, valeric, hexanoic, and oxalacetic. These acids also retarded iron oxidation by the cells. Electron microscope observation of cells after exposure to the organic acids showed varying degrees of cell envelope disruption, suggesting that the mode of inhibition of autotrophic iron oxidation in the cell involves interference with the function of the cell envelope, possibly the cell membrane.
mesh_terms: D000143:Acids / Q000494:pharmacology*; D002087:Butyrates / Q000494:pharmacology; D002208:Caproates / Q000494:pharmacology; D002473:Cell Wall / Q000187:drug effects / Q000648:ultrastructure; D004269:DNA, Bacterial / Q000378:metabolism*; D007501:Iron / Q000378:metabolism*; D010071:Oxaloacetates / Q000494:pharmacology; D010710:Phosphates / Q000378:metabolism*; D011422:Propionates / Q000494:pharmacology; D012329:RNA, Bacterial / Q000378:metabolism*; D013855:Thiobacillus / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D014631:Valerates / Q000494:pharmacology
chemical_list: D000143:Acids; D002087:Butyrates; D002208:Caproates; D004269:DNA, Bacterial; D010071:Oxaloacetates; D010710:Phosphates; D011422:Propionates; D012329:RNA, Bacterial; D014631:Valerates; D007501:Iron