In vivo and in vitro effect of bacterial endotoxin on erythroid precursors (CFU-E and ERC) in the bone marrow of mice.
Erythropoietin injection raised within 24 hr. the number of CFU-E in the femoral marrow of polycythemic mice by 837 percent. Endotoxin given at 0 to 24 hr. before erythropoietin nearly abolished this CFU-E increase. Endotoxin in the culture medium did not inhibit erythroid colony formation, but in vivo endotoxin suppressed erythropoietin-induced differentiation of proerythroblasts from their precursors. Endotoxin thus suppresses marrow erythropoiesis either by inhibiting transformation of erythroid precursors into CFU-E or by causing the disappearance, perhaps by emigration, of CFU-E from the marrow.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000502:physiology; D001854:Bone Marrow Cells; D003470:Culture Media; D004731:Endotoxins / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects*; D004920:Erythropoiesis / Q000187:drug effects*; D004921:Erythropoietin; D005260:Female; D051379:Mice
D003470:Culture Media; D004731:Endotoxins; D004921:Erythropoietin