Antifactor Xa activity in thrombophilia. Studies in a family with Ar-III deficiency.
Antithrombin III (At-III) concentration and amidolytic assays reflecting functions of the At-III molecule were studied in members of a family with a strong tendency to thrombosis. Antifactor Xa and heparin cofactor activity closely parallel at At-III concentration. In all individuals with a history of thrombosis At-III concentration was about 50% of normal. The clinical features and causes of death are briefly reviewed. Mean age in deceased family members with a tendency to thrombosis was 55 years, in members with no history of thrombosis it was 65 years.
D000328:Adult; D000368:Aged; D000990:Antithrombin III / Q000378:metabolism; D000991:Antithrombins / Q000032:analysis; D005171:Factor X Deficiency / Q000097:blood*; D005260:Female; D006801:Humans; D007020:Hypoprothrombinemias / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D013927:Thrombosis / Q000097:blood* / Q000235:genetics
D000991:Antithrombins; D000990:Antithrombin III