[Possible mechanism of action of oxythiamine on nucleic acid metabolism].
Hydoxythiamine injections (400 mg/kg for 72 hours) resulted in the inhibition of transketolase activity and of 14C-orotic acid incorporation into RNA in rat liver tissue. At the same time, the decrease of RNA and phosphoribosylpyrophosphate levels has been observed, which suggests a regulation effect (via pentospohosphates) of hydroxythiamine on nucleotide and nucleic acid metabolism.
D000818:Animals; D004247:DNA / Q000378:metabolism*; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D009963:Orotic Acid / Q000378:metabolism; D010119:Oxythiamine / Q000494:pharmacology*; D010754:Phosphoribosyl Pyrophosphate / Q000378:metabolism; D012313:RNA / Q000378:metabolism*; D051381:Rats; D013844:Thiazoles / Q000494:pharmacology*; D014174:Transketolase / Q000037:antagonists & inhibitors*
D013844:Thiazoles; D010119:Oxythiamine; D009963:Orotic Acid; D012313:RNA; D010754:Phosphoribosyl Pyrophosphate; D004247:DNA; D014174:Transketolase
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