title: Postnatal development of the suprachiasmatic hypothalamic nucleus of the rat.
abstract: Light and electron microscopy of newborn, four day, one, two, three and five week old rats revealed principally a progressive increase in the diversity and number of synaptic contacts in the suprachiasmatic nucleus (SCN). The major increase in synaptic diversity occurred between four days and one week of age. Correlation between this finding and the adult synaptic morphology of SCN (Gülder, 1976) on the one hand, and the ontogeny of circadian rhythms on the other were made. This suggested that the retinal afferents arriving on day four form asymmetrical contacts with dendrites. While increase in synaptic number was progressive, it was most marked between three and five weeks of age. By five weeks, most features of the adult SCN were present. No significant morphological effects were evident as a result of neonatal retinal lesions.
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002940:Circadian Rhythm; D007031:Hypothalamus / Q000254:growth & development*; D007032:Hypothalamus, Anterior / Q000254:growth & development* / Q000648:ultrastructure; D008027:Light; D008854:Microscopy, Electron; D051381:Rats; D013569:Synapses / Q000648:ultrastructure; D014795:Visual Pathways / Q000254:growth & development