Antibody-mediated suppression of tumor growth. II. Macrophage and platelet cooperation with murine IgG1 isolated from alloantiserum.
The effectors that cooperate with IgG1 in causing tumor suppression were identified as exudate macrophages and blood platelets in animals syngeneic and allogeneic to the tumor. Lymphocytes were not active in suppressing tumor growth in the presence of IgG1 antibody, although they were active with whole antiserum.
D000818:Animals; D000918:Antibody Specificity; D001792:Blood Platelets / Q000276:immunology*; D002471:Cell Transformation, Neoplastic; D007106:Immune Sera; D007074:Immunoglobulin G / Q000302:isolation & purification* / Q000378:metabolism; D007165:Immunosuppression Therapy; D007518:Isoantibodies; D008214:Lymphocytes / Q000276:immunology; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL
D007106:Immune Sera; D007074:Immunoglobulin G; D007518:Isoantibodies