Mechanism of cinnamaldehyde sensitization.
The skin sensitization of cinnamaldehyde is probably initiated by the reaction of cinnamaldehyde with epsilon-amino groups on protein side chains. Alpha-Substituted cinnamaldehydes, which are known not to be skin sensitizers, react very slowly or not at all with amines in comparison with cinnamaldehyde.
D000818:Animals; D003877:Dermatitis, Contact / Q000209:etiology*; D006168:Guinea Pigs; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology; D010476:Perfume / Q000009:adverse effects*; D012867:Skin / Q000276:immunology
D010476:Perfume