title: Concentrations of levamisole required for enhanced proliferation of human lymphocytes and phagocytosis by macrophages.
abstract: We studied the in vitro effects of levamisole on phagocytosis by macrophages and on proliferation of lymphocytes obtained from human peripheral blood. It was observed that levamisole directly stimulated phagocytosis in a lymphocyte-free system. Enhancement was optimal at a concentration that inhibited antigen- or mitogen-induced stimulation of sensitive lymphocytes. Lower concentrations of levamisole enhanced the proliferative lymphocyte response.
mesh_terms: D004305:Dose-Response Relationship, Drug; D006801:Humans; D007978:Levamisole / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects*; D008264:Macrophages / Q000187:drug effects; D010587:Phagocytosis / Q000187:drug effects*; D011137:Polystyrenes
chemical_list: D011137:Polystyrenes; D007978:Levamisole