title: Solid phase synthesis and some hormonal activities of 8-L-homoarginine-vasotocin and 1-deamino-8-L-homoarginine-vasotocin.
abstract: 8-L-Homoarginine-vasotocin and its 1-deamino derivative were synthesized by the solid phase method. Both compounds possessed high activities in the uterus contraction and fowl depressor assays and showed higher pressor activities than the corresponding vasopressins. Homoarginine-vasotocin, unexpectedly, was a more potent antidiuretic agent than its deamino analogue.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001681:Biological Assay; D004231:Diuresis / Q000187:drug effects; D005260:Female; D011312:Pressure; D051381:Rats; D013329:Structure-Activity Relationship; D014590:Uterine Contraction / Q000187:drug effects; D014668:Vasotocin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D014668:Vasotocin