title: The effect of altering thyroid hormone concentrations on plasma gonadotrophins in postmenopausal women.
abstract: Plasma gonadotrophin levels were measured at frequent intervals in six postmenopausal thyrotoxic women treated with carbimazole. All patients showed an increasing follicle stimulating hormone/luteinizing hormone (FSH/LH) ratio as the thyroid hormone concentrations fell to normal and then into the hypothyroid range. Although the increased FSH/LH ratio was primarily due to a rise of FSH, two patients had a rise of both gonadotrophins. It is suggested that menstrual irregularities occurring in premenopausal women with disorders of thyroid metabolism may be related to similar changes.
mesh_terms: D000368:Aged; D002231:Carbimazole / Q000627:therapeutic use; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D006062:Gonadotropins / Q000097:blood*; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy; D007986:Luteinizing Hormone / Q000378:metabolism; D008593:Menopause; D008875:Middle Aged; D013963:Thyroid Hormones / Q000378:metabolism*
chemical_list: D006062:Gonadotropins; D013963:Thyroid Hormones; D002231:Carbimazole; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone