Chdromosome aberrations in mice by the antifungal antibiotic, nystatin.
Nystatin, a fungicide of current medical use, was tested in mice for its effect on chromosomes of bone marrow cells. A significant increase of aberrations, mostly of chromatid type, was observed over a period of from 15 min to 15 days following the application of the drug. Our data indicate a non-random distribution of the breaks.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000502:physiology; D001854:Bone Marrow Cells; D002842:Chromatids / Q000187:drug effects / Q000502:physiology; D002869:Chromosome Aberrations; D003433:Crosses, Genetic; D005260:Female; D008297:Male; D051379:Mice; D009761:Nystatin / Q000494:pharmacology*; D014178:Translocation, Genetic / Q000187:drug effects
D009761:Nystatin