title: Massive weight loss following jejunoileal bypass. I. Effects on pulmonary function.
abstract: Twelve morbidly obese patients had jejunoileal bypass surgery and serial detailed pulmonary function studies done over a one year period. Before operation they showed evidence of a decreased ventilation: perfusion ratio producing a "shuntlike effect" (Pao2 = 73, Paco2 = 37, pH = 7.44) while breathing room air (FIo2 = 0.209). They also had measurements consistent with pure restrictive lung disease. There was a highly significant improvement in the arterial oxygenation over the entire one year period and a significant loss of chest wall mass over the first 6 month period. The improved oxygenation most likely was due to a return of lung volumes toward normal and an improvement in the efficiency of the respiratory muscles.
mesh_terms: D000293:Adolescent; D000328:Adult; D001835:Body Weight; D005260:Female; D006801:Humans; D007082:Ileum / Q000601:surgery*; D007583:Jejunum / Q000601:surgery*; D008297:Male; D009765:Obesity / Q000628:therapy*; D010100:Oxygen / Q000097:blood; D012119:Respiration; D012129:Respiratory Function Tests
chemical_list: D010100:Oxygen