Antiinflammatory activity of isomeric phenylnaphthaleneacetic acids.
The isomeric phenylnaphthaleneacetic acids were prepared and tested for antiinflammatory activity by the anti-UV-erythema method. High potency was exhibited by 4- and 5-phenyl-1-naphthaleneacetic acid and 5- and 6-phenyl-2-naphthaleneacetic acid. The results are discussed in terms of a hypothetical receptor site.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D004890:Erythema / Q000188:drug therapy; D006168:Guinea Pigs; D007536:Isomerism; D009280:Naphthaleneacetic Acids / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D013329:Structure-Activity Relationship
D000893:Anti-Inflammatory Agents; D009280:Naphthaleneacetic Acids