Hemolysis due to chemical contamination of clinical perfusion apparatus.
A chemical contaminant found on the interior surface of the extracorporeal apparatus manufactured by the William Harvey Corporation was believed to have caused severe hematuria in 2 children. The biological activity of the contaminant was tested by mixing 50 ml of whole blood in contaminated cardiotomies; after 5 minutes of exposure lysis of one-sixth of the red blood cells was found. This hemolytic agent was concluded to be bisphenol A dissolved in an organic solvent, but the mechanism of contamination was never found.
D001559:Benzhydryl Compounds / Q000506:poisoning*; D002315:Cardiopulmonary Bypass / Q000592:standards; D002675:Child, Preschool; D005112:Extracorporeal Circulation / Q000592:standards*; D005260:Female; D006417:Hematuria / Q000139:chemically induced*; D006461:Hemolysis; D006801:Humans; D010636:Phenols / Q000506:poisoning*; D012997:Solvents / Q000506:poisoning*
D001559:Benzhydryl Compounds; D010636:Phenols; D012997:Solvents