Enhancement of the biological activity of adenosine analogs by the adenosine deaminase inhibitor 2'-deoxycoformycin.
The potent adenosine deaminase inhibitor 2'-deoxycoformycin ((R)-3-(2-deoxy-beta-D-erythropentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol) inhibits the enzymic inactivation and potentiates the cytotoxic activity of a variety of adenosine analogs in the P388 murine leukemia cell culture system. The activity of all seven adenosine analogs examined was enhanced by 2'-deoxycoformycin with the exception of tubercidin (7-deaza-adenosine) which is not a substrate for the deaminase. In vivo, 2'-deoxy-coformycin potentiated the antineoplastic activity of 9-beta-D-xylofuranosyladenine in mice with P388 murine leukemia.
D000241:Adenosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D058892:Adenosine Deaminase Inhibitors; D000818:Animals; D001381:Azepines / Q000494:pharmacology*; D002478:Cells, Cultured; D003853:Deoxyribonucleosides / Q000494:pharmacology*; D004357:Drug Synergism; D005260:Female; D007942:Leukemia, Experimental / Q000188:drug therapy; D051379:Mice; D009700:Nucleoside Deaminases / Q000037:antagonists & inhibitors*
D058892:Adenosine Deaminase Inhibitors; D001381:Azepines; D003853:Deoxyribonucleosides; D009700:Nucleoside Deaminases; D000241:Adenosine