Linoleic acid amides: effect on cholesteremia and atherosclerosis.
Several of a series of linoleic acid amides have been reported to inhibit cholesterol-induced atherosclerosis in rabbits. The three amides which have been studied to the greatest extent are (in order of increasing activity) N-cyclohexyl linoleamide (AC23), N(alpha methylbenzyl) linoleamide (AC223), and N[aplha-phenyl-beta-(p-tolyl)ethyl] linoeamide (AC 485).                                                                               We have found AC223 to inhibit cholesterol absorption in rats and to slightly inhibit exogenous but not endogenous cholesteremia in rabbits. In a fiber-free diet, AC223 reduces serum cholesterol and liver triglyceride levels. Rats were also fed a basal semipurified diet with and without AC223. Fecal excretion of labeled exogenous (as [ (14)C] cholesterol) or endogenous (as [14 C] mevalonolactone) steroid was 44 and 43% higher in drug treated groups. The mechanism of hypocholesteremic action of the linoleamides appears to involve inhibition of cholesterol absorption.
D000577:Amides / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D001161:Arteriosclerosis / Q000188:drug therapy*; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000378:metabolism; D005243:Feces / Q000032:analysis; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy*; D007408:Intestinal Absorption / Q000187:drug effects; D008041:Linoleic Acids / Q000494:pharmacology / Q000627:therapeutic use*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011817:Rabbits; D013256:Steroids / Q000378:metabolism; D014280:Triglycerides / Q000097:blood
D000577:Amides; D008041:Linoleic Acids; D013256:Steroids; D014280:Triglycerides; D002784:Cholesterol