[Calculation of the Chance of paternity exclusion and of the probability of paternity for the HLA system (author's transl)].
The genetics of the serological defined SD antigens of the HLA system, which are governed by three closely linked loci (HLA-A, HLA-B and HLA-C) situated on the chromosome C6, are described. Regarding patermity testing, only the antigens coded by the loci HLA-A and HLA-B are used routinely up to now. Because of the strong linkage disequilibrium between these two loci, they cannot be considered as independent. The influence of the linkage disequilibrium on the calculation of the chance of paternity exclusion and of the plausibility of paternity is discussed and demonstrated in several examples.
D000328:Adult; D002648:Child; D005260:Female; D005787:Gene Frequency; D006680:HLA Antigens / Q000032:analysis*; D006649:Histocompatibility Antigens / Q000032:analysis*; D006801:Humans; D008297:Male; D010334:Paternity; D011336:Probability
D006680:HLA Antigens; D006649:Histocompatibility Antigens
Berechnung der Vaterschaftsausschlusschance und der Vaterschaftswahrscheinlichkeit im HLA System