The metabolism of [6-3H]1alpha, hydroxycholecalciferol to [6-3H]1alpha,25-dihydroxycholecalciferol in a patient with renal insufficiency.
To evaluate whether 1alpha-hydroxycholecalciferol is metabolized to 1alpha,25-dihydroxycholecalciferol in man, [6-3H]1alpha-hydroxycholecalciferol was given intravenously to a patient with renal failure who was maintained daily on 100,000 IU vitamin D and calcium supplements. Using Sephadex LH-20 and high-pressure liquid chromatography, it was clearly demonstrated that 1alpha-hydroxycholecalciferol rapidly disappears from the blood and is metabolized to 1alpha,25-dihydroxycholecalciferol.
D004100:Dihydroxycholecalciferols / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D006887:Hydroxycholecalciferols / Q000096:biosynthesis* / Q000378:metabolism*; D007674:Kidney Diseases / Q000378:metabolism*; D008875:Middle Aged; D013250:Steroid Hydroxylases / Q000378:metabolism
D004100:Dihydroxycholecalciferols; D006887:Hydroxycholecalciferols; D013250:Steroid Hydroxylases