The role of sialic acid in determining the survival of circulating interferon.
Rabbit interferon has been extensively desialytated and its metabolic behaviour has been evaluated in the rabbit. The half-life of asialointerferon is significantly shorter than the native interferon and its urinary excretion becomes negligible. Moreover the rapid uptake of asialointerferon by the isolated and perfused rabbit liver, suggests a hitherto unsuspected catobolic pathway for this glycoprotein.
D000818:Animals; D007372:Interferons / Q000097:blood / Q000378:metabolism* / Q000652:urine; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D009439:Neuraminidase; D011817:Rabbits; D012794:Sialic Acids / Q000378:metabolism*
D012794:Sialic Acids; D007372:Interferons; D009439:Neuraminidase