[Biogenic amines and adrenal cortical function in breast cancer].
Under study were the content of serotonin and 11-OCS in blood and diurnal excretion of 5-OIAA, adrenaline and noradrenaline in 71 pateints with breast cancer. The data obtained indicated that the examined patients, compared with the control group, show a reliably higher concentration of serotonin and 11-OCS in blood (70.4% and 19.5% correspondingly), an insignificantly increased excretion of 5-OIAA, a markedly increased diurnal excretion of adrenaline (by 96.4%), whereas a decreased excretion of noradrenaline (by 73.1%). The character of changes in the indices under study was definitely dependent on the stage of the disease (in stages 1-11 these changes were mostly pronounced), and patients' age (in young patients the adrenal cortex activity was rather intensive, whereas in aged patients biologically active substances were manifest).
D015062:11-Hydroxycorticosteroids / Q000097:blood; D000302:Adrenal Cortex / Q000503:physiopathology*; D000311:Adrenal Glands / Q000503:physiopathology*; D000328:Adult; D000367:Age Factors; D000368:Aged; D001679:Biogenic Amines / Q000378:metabolism*; D001943:Breast Neoplasms / Q000503:physiopathology*; D002940:Circadian Rhythm; D004837:Epinephrine / Q000652:urine; D005260:Female; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000652:urine; D008875:Middle Aged; D009638:Norepinephrine / Q000652:urine; D012701:Serotonin / Q000097:blood
D015062:11-Hydroxycorticosteroids; D001679:Biogenic Amines; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D009638:Norepinephrine; D004837:Epinephrine
Biogennye aminy i funktsiia kory nadpochechnikov u bol'nykh rakom molochnoĭ zhelezy