Continuing disease process of calcific aortic stenosis. Role of microthrombi and turbulent flow.
Microthrombi with evidence of organization were observed in 10 of 19 calcified and stenotic aortic valves (53 percent). The organization that results from such thrombi may contribute to the deformity of the valve. Repetitive deposits of microthrombi, followed by organization and calcification, would explain the continuous process of stenosis in previously deformed aortic valves. The formation of such thrombi may be initiated by turbulent flow and other fluid dynamic factors.
D000328:Adult; D000368:Aged; D001021:Aortic Valve / Q000473:pathology; D001024:Aortic Valve Stenosis / Q000209:etiology*; D002114:Calcinosis / Q000150:complications*; D003326:Coronary Circulation; D006801:Humans; D008875:Middle Aged; D010973:Platelet Adhesiveness; D010974:Platelet Aggregation; D013917:Thrombin; D013927:Thrombosis / Q000150:complications* / Q000209:etiology / Q000473:pathology
D013917:Thrombin