Isolation of a hypertension-producing compound from normal human urine.
A protein fraction has been isolated from normal human urine which, when injected over a period of 10-15 days in normal rats, produced sustained hypertension. On cessation of injection, the blood pressure fell to normal level within 7-10 days. The hypertension was accompanied by expansion of plasma volume, retention of sodium, and alteration in urinary Na/K ratio. Further, it led to hypertrophy of the adrenal cortex and increased circulating aldosterone without a change in plasma corticosterone values. These results suggest that the protein fraction increased arterial pressure in rats through direct stimulation of aldosterone production resulting in sodium retention and volume expansion.
D000450:Aldosterone / Q000652:urine; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001810:Blood Volume / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000209:etiology*; D007668:Kidney / Q000378:metabolism; D008970:Molecular Weight; D011188:Potassium / Q000652:urine; D011506:Proteins / Q000494:pharmacology; D011507:Proteinuria; D051381:Rats; D012083:Renin / Q000378:metabolism; D012964:Sodium / Q000652:urine
D011506:Proteins; D000450:Aldosterone; D012964:Sodium; D012083:Renin; D011188:Potassium