[Gliadin-induced migration inhibition of peripheral leucocytes by the agarose-plate technique in patients with coeliac disease (author's transl)].
Sensitisation to gliadin was studied--using a modified leucocyte-migration inhibtion test after Clausen--in patients with coeliac disease (10 patients), ulcerative colitis (9), terminal ileitis (9), bacterial diarrhoea (9), and other gastro-intestinal diseases (14). Only the group of patients with coeliac disease had such specific sensitisation. The migration index, at 0.72 +/- 0.06, was significantly lower in them than in other groups. This reaction is disease-specific and indicates that in coeliac disease cellular immune mechanisms also play a role. The specificity of the reaction can also be used diagnostically.
D002446:Celiac Disease / Q000276:immunology*; D002464:Cell Migration Inhibition; D002465:Cell Movement / Q000187:drug effects; D003093:Colitis, Ulcerative / Q000276:immunology; D003110:Colonic Neoplasms / Q000276:immunology; D003424:Crohn Disease / Q000276:immunology; D003967:Diarrhea / Q000276:immunology; D004381:Duodenal Ulcer / Q000276:immunology; D005903:Gliadin / Q000494:pharmacology; D006801:Humans; D007111:Immunity, Cellular; D007962:Leukocytes / Q000276:immunology*; D010195:Pancreatitis / Q000276:immunology; D010940:Plant Proteins / Q000494:pharmacology; D013276:Stomach Ulcer / Q000276:immunology
D010940:Plant Proteins; D005903:Gliadin
Gliadin-induzierte Migrationshemmung peripherer Leukozyten in der Agaroseplattentechnik bei Patienten mit Coeliakie