[Effects of methylcyclopentadienyl manganese tricarbonyl (MMT) of rat liver mitochondria. I. Effects, in vitro, on the oxidative phosphorylation (author's transl)].
Methylcyclopentadienyl manganese tricarbonyl (MMT) is an effective inhibitor of mitochondrial respiration associated with NAD+-linked substrates. At concentrations which inhibit glutamate-malate oxidation (over 80% inhibition) succinate and tetramethylphenylenediamine (TMPD)-ascorbate are inhibited less than 25%. MMT inhibits both electron and energy transfer in mitochondria as revealed by the partial release of MMT inhibition by 2,4-dinitrophenol (DNP). The data indicated that the effects of MMT are supported by energy conservation at site I of the respiratory chain.
D000818:Animals; D003517:Cyclopentanes / Q000494:pharmacology; D003864:Depression, Chemical; D004140:Dinitrophenols / Q000494:pharmacology; D005971:Glutamates / Q000378:metabolism; D066298:In Vitro Techniques; D008293:Malates / Q000378:metabolism; D008297:Male; D008345:Manganese / Q000494:pharmacology*; D008930:Mitochondria, Liver / Q000378:metabolism*; D009942:Organometallic Compounds / Q000494:pharmacology*; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects; D010710:Phosphates / Q000494:pharmacology; D051381:Rats; D013974:Thyroxine / Q000494:pharmacology; D013997:Time Factors
D003517:Cyclopentanes; D004140:Dinitrophenols; D005971:Glutamates; D008293:Malates; D009942:Organometallic Compounds; D010710:Phosphates; C009907:2-methylcyclopentadienyl manganese tricarbonyl; D008345:Manganese; D013974:Thyroxine
Action du manganese methylcyclopentadienyle tricarbonyle (MMT) sur les mitochondries I. Effets du MMT, in vitro, sur la phosphorylation oxydative des mitochondries hepatiques de rats