Inherited chromosomal translocation in two families (t(4q-;13q+) and t(5q-; 13q+)).
Two families with reciprocal translocations, t(4q-; 13q+) and t(5q-; 13q+), are reported. Each proband carried multiple malformations resulting from the unbalanced segregation in two mothers of balanced carriers. The karyotype-phenotype relationship is discussed with reference to other previously reported cases of B/D translocation.
D000015:Abnormalities, Multiple / Q000235:genetics; D001399:Azure Stains; D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D002875:Chromosomes / Q000648:ultrastructure; D002901:Chromosomes, Human, 13-15; D002905:Chromosomes, Human, 4-5; D004423:Ear / Q000002:abnormalities; D005260:Female; D006801:Humans; D007223:Infant; D007621:Karyotyping; D008831:Microcephaly / Q000235:genetics; D010375:Pedigree; D010641:Phenotype; D014178:Translocation, Genetic
D001399:Azure Stains