Uncoupling of mitochondrial respiration by ADP.
Even when oxidative phosphorylation is blocked completely by addition of high concentrations of oligomycin plus aurovertin, the addition of ADP to a suspension of mitochondria containing a high concentration of ATP inside the mitochondria induces a stimulation of respiration and oxidation of nicotinamide nucleotide. It is concluded that transport of ADP into mitochondria with a high endogenous ATP/ADP ratio requires energy.
D000244:Adenosine Diphosphate / Q000494:pharmacology*; D000818:Animals; D001313:Aurovertins / Q000494:pharmacology; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D009840:Oligomycins / Q000494:pharmacology; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects*; D051381:Rats; D014475:Uncoupling Agents
D001313:Aurovertins; D009840:Oligomycins; D014475:Uncoupling Agents; D000244:Adenosine Diphosphate