A study on the dimeric structure of creatine kinase (EC 2.7.3.2).
The generally accepted dimeric structure of creatine kinase (CK) is one in which M subunits and B subunits can occur. This paper reports the existence of three MM-bands and two MB-bands in human sera with increased CK-activity. These findings and supplementary data gathered from hybridisation experiments have led to the conclusion that there are two different M subunits, which can both occur in the enzyme in vivo. Further, findings are reported on the different CK-isozyme patterns of extracts from the cerebellum and from the cortex and the medulla of the cerebrum.
D001921:Brain / Q000201:enzymology; D003402:Creatine Kinase / Q000097:blood / Q000378:metabolism; D004587:Electrophoresis, Agar Gel; D006801:Humans; D007527:Isoenzymes / Q000097:blood / Q000378:metabolism; D046911:Macromolecular Substances; D009928:Organ Specificity; D011485:Protein Binding
D007527:Isoenzymes; D046911:Macromolecular Substances; D003402:Creatine Kinase