Pharmacokinetic analysis of drug concentration data obtained during repetitive drug administration.
A digital computer curve-fitting method, designed to estimate pharmacokinetic model constants by utilizing all drug concentration-time data collected during repetitive dosing studies, was applied to data manifesting systematic dose-to-dose variability in one or another of the pharmacokinetic parameters. The method accurately determined dose-to-dose changes in absorption or elimination rate constants or in the apparent volume of distribution, and it would be useful for detecting phenomena such as self-induction and self-inhibition that may occur during multiple-dose administration. The method can also be used to analyze multiple-dose data of drugs exhibiting capacity-limited elimination and to obtain estimates of the Michaelis-Menten parameters.
D003201:Computers; D006801:Humans; D007408:Intestinal Absorption; D007700:Kinetics; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000378:metabolism*; D010672:Phenytoin / Q000008:administration & dosage / Q000097:blood; D013752:Tetracycline / Q000008:administration & dosage / Q000097:blood; D013997:Time Factors
D004364:Pharmaceutical Preparations; D010672:Phenytoin; D013752:Tetracycline