Procainamide-induced systemic lupus erythematosus with hypocomplementemia.
Procainamide-induced systemic lupus erythematosus (SLE) is a well recognized clinical syndrome believed to be characterized by normocomplementemia. However, in 7 cases of drug-induced SLE recorded in the literature, hypocomplementemia was found. The present report concerns a well documented case of procainamide-induce SLE with hypocomplementemia. The patient improved and complement values returned to normal after procainamide therapy was discontinued and replaced by digitalis and steroid therapy.
D000368:Aged; D003165:Complement System Proteins / Q000032:analysis; D004077:Digoxin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced*; D011241:Prednisone / Q000627:therapeutic use; D011342:Procainamide / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use
D004077:Digoxin; D003165:Complement System Proteins; D011342:Procainamide; D011241:Prednisone