The effect of 2,3-diphosphoglycerate on oxygen consumption burst in thrombin-stimulated platelets.
2,3-Diphosphoglycerate (2,3-DPG) modifies platelet function; it diminishes aggregation and the release reaction. The hypothesis that this occurs through a modification of the intracellular level of cyclic AMP or through an alteration in the synthesis of prostaglandins has been proposed. Since the release reaction occurs simultaneously with a burst in the consumption of oxygen, the authors have studied the effect of 2,3-DPG on oxygen consumption after the addition of thrombin with or without the addition of substances which modify platelet metabolism (aspirin, theophylline, glucagon, etc.). It was observed that 2,3-DPG diminishes oxygen consumption induced by thrombin. This mechanism alters the platelet membrane function.
D000328:Adult; D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology*; D004163:Diphosphoglyceric Acids / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D010101:Oxygen Consumption / Q000187:drug effects*; D010974:Platelet Aggregation / Q000187:drug effects; D013917:Thrombin / Q000494:pharmacology / Q000502:physiology*
D004163:Diphosphoglyceric Acids; D013917:Thrombin