Re-evaluation of amino-oxyacetate as an inhibitor.
Data are provided which indicate that pyruvate and/or acetaldehyde can reverse the inhibition of alanine aminotransferase and aspartate aminotransferase by amino-oxyacetate. It was shown that acetaldehyde could reverse the inhibition of gluconeogenesis from alanine and that pyruvate could reverse the inhibition of urea synthesis by amino-oxyacetate.
D000079:Acetaldehyde / Q000494:pharmacology; D000085:Acetates / Q000494:pharmacology*; D000625:Aminooxyacetic Acid / Q000494:pharmacology*; D000818:Animals; D008099:Liver / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D011773:Pyruvates / Q000494:pharmacology; D051381:Rats; D000637:Transaminases / Q000037:antagonists & inhibitors*
D000085:Acetates; D011773:Pyruvates; D000625:Aminooxyacetic Acid; D000637:Transaminases; D000079:Acetaldehyde