Stimulation of macrophage DNA synthesis in culture by different types of acute non immunological inflammatory exudates.
Acute non immunological inflammatory pleural exudates provoked by four different irritants and collected 4 hours later have been shown to be capable of stimulating DNA synthesis, in rat peritoneal macrophages in culture. It is postulated that a mitogenic factor, "Inflammatory Mitogenic Factor for Macrophages" IMF (M), could be responsible for this phenomenon. There may be a correlation between the protein concentration of the exudates and its mitogenic activity.
D000818:Animals; D001202:Ascitic Fluid; D004261:DNA Replication; D007249:Inflammation / Q000503:physiopathology*; D007962:Leukocytes / Q000502:physiology; D008264:Macrophages / Q000378:metabolism*; D011506:Proteins / Q000502:physiology; D051381:Rats
D011506:Proteins