[Interacetion of myeloid and stromal bone marrow elements in acute experimental aplasia].
Acute hypoplasia of the hemopoiesis was induced in guinea pigs by the administration of vynbalstin  in  a dose of 0.1 mg per 100 g of weight, intraperitoneally, once or twice at an interval of 7 days. Myelokariocyte count, the concentration (per 10(5) of myelokariocytes) and the total amount of the fibroblast precursors was determined in the femur by the fibroblast colony method. After the administration of the cytostatic, simultaneously with the reduction of the myelokariocyte count there was noted a change in the concentration of the stromal precursors and a fall of the total precursor count per femur. It is supposed that the bone marrow reaction under hypoplasia conditions was caused by the interaction of the myeloid and stromal elements.
D000208:Acute Disease; D000741:Anemia, Aplastic / Q000139:chemically induced / Q000473:pathology*; D000818:Animals; D001853:Bone Marrow; D001854:Bone Marrow Cells; D002452:Cell Count; D002999:Clone Cells; D003238:Connective Tissue; D003239:Connective Tissue Cells; D006168:Guinea Pigs; D013997:Time Factors; D014747:Vinblastine
D014747:Vinblastine
O vzaimootnoshenii mieloidnykh i stromal'nykh élementov kostnogo mozga pri ostroĭ éksperimental'noĭ aplazii