A physiological sealant for cerebrospinal fluid leaks.
A combination of concentrated platelets, thrombin, and fibronogen was used to adhere a pericranial graft to surgically produced cerebrospinal fuild (CSF) fistulas in dogs. This sealant successfully stopped leakage of CSF in all fistulas produced in both acute and chronic preparations. All control animals leaked CSF acutely. In chronic control animals the CSF leaks sealed spontaneously but the grafts were not well incorporated. Histoligical examination of the grafts and underlying brain showed not injury to the brain of meningeal vessel from exposure to the platelet glue. Good fibrous union of the grafts to the dura was confirmed.
D000818:Animals; D002555:Cerebrospinal Fluid; D004285:Dogs; D004388:Dura Mater / Q000601:surgery; D005260:Female; D005402:Fistula / Q000601:surgery*; D008297:Male; D014014:Tissue Adhesives / Q000627:therapeutic use*
D014014:Tissue Adhesives