Monitoring digoxin therapy: II. Determinants of the apparent volume of distribution.
1 In eighteen subjects receiving digoxin therapy the apparent volume of distribution (Vd) of the drug has been calculated. 2 For each subject the sensitivity of the 86Rb transport mechanism of his pre-treatment erythrocytes to in vitro inhibition by digoxin has been measured (IC50). 3 The Vd of digoxin correlates both with the age of the patients and with the IC50 of their pre-treatment erythrocytes. 4 The implications of these findings are discussed in terms of the possible determinants of the Vd of digoxin. 5 Digoxin requirements may be predictable before therapy commences if IC50 measurements are performed.
D000328:Adult; D000367:Age Factors; D000368:Aged; D004077:Digoxin / Q000378:metabolism* / Q000494:pharmacology / Q000627:therapeutic use; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D008722:Methods; D008875:Middle Aged; D008954:Models, Biological; D011868:Radioisotopes; D012044:Regression Analysis; D012413:Rubidium / Q000097:blood
D011868:Radioisotopes; D004077:Digoxin; D012413:Rubidium