title: Inhibition of haem synthesis caused by cobalt in rat liver. Evidence for two different sites of action.
abstract: Cobalt inhibits liver haem synthesis in vivo by acting at least two different sites in the biosynthetic pathway: (1) synthesis of 5-aminolaevulinate and (2) conversion of 5-amino-laevulinate into haem. The first effect is largely, if not entirely, due to inhibition of the activity of 5-aminolaevulinate synthase, rather than to inhibition of the formation of the enzyme. The second effect results from diversion of 5-aminolaevulinate into an unidentified liver pool with solubility properties similar to those of cobalt protoporphyrin.
mesh_terms: D000624:5-Aminolevulinate Synthetase / Q000378:metabolism; D000622:Aminolevulinic Acid / Q000378:metabolism; D003035:Cobalt / Q000494:pharmacology*; D006418:Heme / Q000096:biosynthesis*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism
chemical_list: D003035:Cobalt; D006418:Heme; D000622:Aminolevulinic Acid; D000624:5-Aminolevulinate Synthetase