title: Immediate effects of tobramycin on human cochlea and correlation with serum tobramycin levels.
abstract: Electrocochleography was performed on three patients to monitor the intravenous administration of tobramycin. When peak serum tobramycin levels exceeded 8-10 mug/ml an immediate dramatic reduction in cochlear output was observed, which recovered fully as serum levels fell. The patients had no auditory or vestibular symptoms either during or after treatment.
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D003051:Cochlea / Q000187:drug effects*; D005260:Female; D006311:Hearing Disorders / Q000139:chemically induced* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D014031:Tobramycin / Q000009:adverse effects* / Q000097:blood
chemical_list: D000900:Anti-Bacterial Agents; D014031:Tobramycin