The effects of indomethacin on long-wave ultraviolet-induced delayed erythema.
Indomethacin, a known inhibitor of prostaglandin synthesis, administered topically as a 2.5% solution, intradermally in 10 mug doses, and orally in a dose of 150 mg/day for 2 days did not diminish the delayed erythema produced a long-wave ultraviolet light (320-400 nm). The delayed phototoxic erythema produced by 8-methoxypsoralen and subsequent exposure the long-wave ultraviolet light was similarly unaffected. By comparison, topical and intradermal indomethacin treatment produced sustained decrease in the erythemal response to ultraviolet radiation in the UVB ranges (290-320 nm).
D000284:Administration, Oral; D000287:Administration, Topical; D000328:Adult; D004890:Erythema / Q000188:drug therapy / Q000209:etiology*; D005363:Ficusin; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage / Q000627:therapeutic use*; D007271:Injections, Intradermal; D013997:Time Factors; D014466:Ultraviolet Rays
D005363:Ficusin; D007213:Indomethacin