Hyper-responsiveness in NZB mice to the experimental induction of anti-red cell autoantibody.
Strain differences in ease of induction of autoantibody production were observed when mice were injected with rat RBC. Responsiveness was not linked to the H-2 locus. NZB and (NZB X BALB/c)F1 mice were hyper-responsive both in terms of the induction of autoantibody and in the production of agglutinating antibody to rat RBC. C57BL/c and (C57BL X BALB/c)F1 were poor responders. Injection of the rat RBC in FCA converted a poor responder into a good responder. Adult thymectomy and ALS treatment did not significantly enhance autoantibody production.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000961:Antilymphocyte Serum / Q000494:pharmacology; D001323:Autoantibodies; D001327:Autoimmune Diseases / Q000139:chemically induced; D003298:Coombs Test; D004912:Erythrocytes / Q000276:immunology*; D051379:Mice; D008814:Mice, Inbred NZB; D013934:Thymectomy
D000961:Antilymphocyte Serum; D001323:Autoantibodies