The effects of long-term exposure of lung fibroblast strains to chrysotile asbestos.
Evidence is presented that persistent long-term exposure of a strain of lung fibroblast-like cells to chrysotile asbestos over 37 passages in vitro leads to enhancement in cell mat collagen deposition and is accompanied by other metabolic alterations in the cultures.
D000818:Animals; D001194:Asbestos / Q000494:pharmacology*; D002460:Cell Line; D003094:Collagen / Q000032:analysis; D004247:DNA / Q000032:analysis; D004391:Dust; D005347:Fibroblasts / Q000187:drug effects / Q000473:pathology; D006909:Hydroxyproline / Q000032:analysis; D008168:Lung / Q000187:drug effects*; D012313:RNA / Q000032:analysis; D011817:Rabbits; D013997:Time Factors
D004391:Dust; D001194:Asbestos; D012313:RNA; D003094:Collagen; D004247:DNA; D006909:Hydroxyproline