Plasma renin activity in men with relation to the presence of ischaemic heart disease.
Plasma renin activity (PRA) stimulated by upright posture was measured, in 300 men aged 45-64 years, by a radio-immunoassay of angiotensin I. The subjucts examined were divided into six groups, comparable in mean age, each containing 50 subjects: group 1, normotensives without manifest atherosclerosis; group 2, normotensives with angina pectoris definite; group 3, normotensives with a history of a transmural myocardial infarction; groups 4 to 6, patients with benign essential hypertension, without manifest atherosclerosis in group 4, with angina pectoris in group 5 and with a history of myocardial infarction in group 6. Significant differences in mean PRA were found between corresponding groups of hypertensives and normotensives, the values in hypertensives being lower. The precentage of low renin values  was higher in hypertensives with ischaemic heart disease than in other groups.  An analysis of 3-year cardiovascular mortality revealed no significant difference in mortality due to ischaemic heart disease between high-renin and low renin sub-groups.
D001786:Blood Glucose / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D003327:Coronary Disease / Q000097:blood* / Q000401:mortality; D003404:Creatinine / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000401:mortality; D008297:Male; D008875:Middle Aged; D012083:Renin / Q000097:blood*; D012306:Risk; D012737:Sex Factors
D001786:Blood Glucose; D002784:Cholesterol; D003404:Creatinine; D012083:Renin