Isolation and identificaton of an in vivo reaction product of 6-hydroxydopamine.
The product of oxidized 6-OHDA and GSH reacted in vitro has been identified by a variety of chemical and physical methods to be 2,4,5-trihydroxy-6-S-(glutathionyl)phenethylamine. Its chemical properties show it easily undergoes a variety of oxidative condensations and polymerization. Its oxidized form, the p-quinone, can be identified in small quantities in rat brain and mouse brain 1-3 h after 6-OHDA injection. This is believed to be the first report of a chemically identified species resulting from the in vivo interaction of 6-OHDA with CNS tissue.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D003500:Cyclization; D005978:Glutathione / Q000378:metabolism; D006892:Hydroxydopamines / Q000378:metabolism*; D007031:Hypothalamus / Q000378:metabolism; D008297:Male; D051379:Mice; D010084:Oxidation-Reduction; D051381:Rats; D013997:Time Factors
D006892:Hydroxydopamines; D005978:Glutathione