title: Effects on hypothalamic and telencephalic NE and 5-HT of tegmental knife cuts that produce hyperphagia or hyperdipsia in the rat.
abstract: Knife cuts in the coronal plane through various aspects of the midbrain tegmentum produced hyperphagia, hyperdipsia, or no effect on ingestive behavior. All of the cuts significantly depleted NE and 5-HT from hypothalamus and forebrain. The brains of hyperphagic or hyperdipsic animals did not differ from those of normophagic and normodipsic animals with respect to hypothalamic NE or 5-HT or telencephalic NE. Both hyperphagic and hyperdipsic animals had significantly lower concentrations of 5-HT in forebrain than rats which sustained similar cuts in the tegmentum which did not affect ingestive behavior.
mesh_terms: D000818:Animals; D001923:Brain Chemistry; D004327:Drinking Behavior / Q000502:physiology*; D005247:Feeding Behavior / Q000502:physiology*; D007031:Hypothalamus / Q000378:metabolism*; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D013681:Tegmentum Mesencephali / Q000502:physiology*; D013687:Telencephalon / Q000378:metabolism*
chemical_list: D012701:Serotonin; D009638:Norepinephrine