Stability of aspirin in propoxyphene compound dosage forms.
The stability of aspirin in propoxyphene compound capsules made by three manufacturers, stored under a variety of temperature and humidity conditions, was compared. The cotton packing was removed from 100-capsule bottles, and the containers were stored (capped) under the following conditions: 25 c37 C and 50 C at both high (90%) and low (10%) humidity. No desiccant was removed from the bottles if originally present. The products tested were Darvon Compound-65 (two formulations) (Lilly), SK-65 Compound (Smith Kline & French) and Dolene Compound-65 (Lederle). Under all conditions, the stability of aspirin in the SK-65 Compound product was greater than that of Darvon Compound-65 which in turn was greater than Dolene Compound-65. Further, the rate of aspirin decomposition was greater in the latter product than in the others.
D001241:Aspirin / Q000008:administration & dosage / Q000032:analysis*; D002214:Capsules / Q000032:analysis; D011431:Dextropropoxyphene / Q000008:administration & dosage*; D004338:Drug Combinations; D004355:Drug Stability; D004356:Drug Storage; D006207:Half-Life; D006813:Humidity; D012459:Salicylates / Q000032:analysis; D013997:Time Factors
D002214:Capsules; D004338:Drug Combinations; D012459:Salicylates; D001241:Aspirin; D011431:Dextropropoxyphene