[Comparative study of the effect of etimizol and hydrocortisone on proliferative activity and protein synthesis in epithelial cells of the tongue and liver].
In contrary to hydrocortisone, the stimulating effect of aethymizol on the mitotic activity of the tongue and liver epithelial cells was revealed 6 hours after its injection. Subsequently reduction of the mitotic activity of hepatocytes appearing in 12 hours was caused by the action of both preparations on the DNA synthesis, rather than by disturbed mitosis. Stimulation of protein synthesis by hydrocortisone and aethymizol was shown by the autoradiogrphic and biochemical methods, when the maximum mitoses were inhibited.
D000818:Animals; D004247:DNA / Q000096:biosynthesis; D004848:Epithelium; D005042:Etimizol / Q000494:pharmacology*; D006854:Hydrocortisone / Q000494:pharmacology*; D007093:Imidazoles / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008938:Mitosis / Q000187:drug effects; D014176:Protein Biosynthesis; D051381:Rats; D014059:Tongue / Q000187:drug effects* / Q000378:metabolism
D007093:Imidazoles; D004247:DNA; D005042:Etimizol; D006854:Hydrocortisone
Sravnitel'noe izuchenie deĭstviia étimizola i gidrokortizona na proliferstivnuiu aktivnost' i sintez belka v épitelial'nykh kletkakh iazyka i pecheni