Assay of human plasma for nortriptyline by radioacetylation and thin-layer chromatography.
A highly specific and sensitive thin-layer chromatographic method for determining nortriptyline levels in plasma is presented. The procedure involves extracting nortriptyline, acetylating it with radioactive acetic anhydride, resolving acetylnortriptyline by thin-layer chromatography, and measuring its radioactivity.
D000107:Acetylation; D002855:Chromatography, Thin Layer; D006801:Humans; D007553:Isotope Labeling; D008722:Methods; D009661:Nortriptyline / Q000031:analogs & derivatives / Q000097:blood*
D009661:Nortriptyline