Prenatal toxicity of medroxyprogesterone acetate in rabbits, rats, and mice.
Medroxyprogesterone acetate (MPA) was given once daily sc at 0.1-3,000 mg/kg/day for 3, 6, or 9 consecutive days during gestation days 7 to 15 to CD1 and A/J mice, and New Zealand (NZ) and Dutch Belted (DB) rabbits, and during days 8 to 16 to CD rats. Malformations attributable to MPA did not occur in fetuses of mice or rats exposed to the largest dosage tested. However, 1, 3, or 10 mg/kg on days 13 to 15 to NZ rabbits resulted in 6, 28, and 42% cleft palate, respectively. Comparable cleft palate frequencies were seen in DB offspring.
D000014:Abnormalities, Drug-Induced; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002972:Cleft Palate / Q000139:chemically induced*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005313:Fetal Death; D005865:Gestational Age; D008431:Maternal-Fetal Exchange; D008525:Medroxyprogesterone / Q000633:toxicity; D051379:Mice; D011247:Pregnancy; D011817:Rabbits; D051381:Rats
D008525:Medroxyprogesterone