Inhibition by PGE2 and by phenylephrine of catecholamine release from human adrenal in vitro.
The release of catecholamines from human adrenal was studied by in vitro incubation of slices. Catecholamine release was significantly inhibited by the addition of either phenylephrine (10(-5) M) or PGE2 (10(-7) M) to the incubation medium. The similarity of these modulating actions to those found in rat adrenal is discussed.
D000293:Adolescent; D000311:Adrenal Glands / Q000378:metabolism*; D000328:Adult; D002395:Catecholamines / Q000378:metabolism*; D003864:Depression, Chemical; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D010656:Phenylephrine / Q000494:pharmacology*; D011458:Prostaglandins E / Q000494:pharmacology*
D002395:Catecholamines; D011458:Prostaglandins E; D010656:Phenylephrine