Serum dopamine-beta-hydroxylase in parkinsonism.
Serum dopamine-beta-hydroxylase activities of a group of 16 parkinsonian patients under L-Dopa plus decarboxylase inhibitor showed a distribution with a drift towards higher activities compared to a group of normals of the same age range. Acute doses of L-Dopa failed to cause any change in the serum enzyme activities as well as in the serum concentration of 3-methoxy-4-hydroxyphenylethylene glycol, in parkinsonian patients and in normals. The data support the idea of a limited influence of L-Dopa on the noradrenaline synthesis and release in parkinsonism.
D000368:Aged; D065105:Aromatic Amino Acid Decarboxylase Inhibitors; D001545:Benserazide; D004299:Dopamine beta-Hydroxylase / Q000097:blood*; D006801:Humans; D007980:Levodopa / Q000494:pharmacology*; D008734:Methoxyhydroxyphenylglycol / Q000097:blood; D008875:Middle Aged; D010300:Parkinson Disease / Q000097:blood / Q000201:enzymology*
D065105:Aromatic Amino Acid Decarboxylase Inhibitors; D007980:Levodopa; D008734:Methoxyhydroxyphenylglycol; D001545:Benserazide; D004299:Dopamine beta-Hydroxylase