Reversal of the toxicity of hydrazine an analogues by pyridoxine hydrochloride.
Single subcutaneous injections of each of five substituted hydrazines were given alone and jointly with pyridoxine hydrochloride (PH) to Swiss mice. The convulsive, toxic, and lethal effects of four compounds--methylhydrazine (MH), ethylhydrazine hydrochloride (EH), n-butylhydrazine hydrochloride (BH), and beta-N-[gamma-L(+)-glutamyl]-4-hydroxymethylphenylhydrazine--were successfully prevented by administering PH before and/or after injection. The toxic symptoms caused by N-methyl-N-formylhydrazine (MFH) were, however, only slightly inhibited by this vitamin.
D000818:Animals; D005260:Female; D006834:Hydrazines / Q000037:antagonists & inhibitors / Q000633:toxicity*; D008297:Male; D051379:Mice; D011736:Pyridoxine / Q000494:pharmacology*; D012640:Seizures / Q000139:chemically induced
D006834:Hydrazines; D011736:Pyridoxine