title: The effects of original and randomized rapseed oils containing high or very low levels of erucic acid on cardiac lipids and myocardial lesions in rats.
abstract: The nutritional status of the very lowerucate, rapseed oil, Brassica napus var. 'Tower,' was compared with that of the high-erucate oil, Brassica napus var. 'Target,' as well as with corn oil. The effect of randomization on the nutritional qualities of rapeseed oil was investigated as well. The feeding of diets containing the original and randomized 'Tower' oil or the original 'Target' oil, at the 20% level by weight, gave growth rates which were not significantly different from that for corn oil. However, the randomized 'Target' oil gave growth rates which were significantly less than all other groups. The growth results could not be explained simply on the basis of food consumption. The level of triglycerides in the hearts of rats fed the very low-erucate oils was not significantly different from the corn oil group. Triglyceride concentrations in the hearts of animals given the high-erucate oils were 7-12 times greater than all other groups. The level of total fatty acids in tissue phospholipids was the same regardless of dietary treatment. Fatty acid compositions of the tissue lipid were the same in animals fed either the original or randomized rapeseed oils. A much higher incidence of focal myocardial necrosis was found in animals receiving high-erucate rapeseed oil relative to animals given the corn oil. The incidence in rats fed diets containing very low-erucate rapeseed oil was intermediate between these latter two extremes.
mesh_terms: D000818:Animals; D001835:Body Weight; D004041:Dietary Fats; D004883:Erucic Acids / Q000494:pharmacology*; D005227:Fatty Acids / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects*; D050356:Lipid Metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D009336:Necrosis; D009821:Oils / Q000378:metabolism*; D051381:Rats; D013997:Time Factors; D014280:Triglycerides / Q000378:metabolism
chemical_list: D004041:Dietary Fats; D004883:Erucic Acids; D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D009821:Oils; D014280:Triglycerides