Relations of renal transport rate, transport maximum, and competitor potency for tetraethylammonium and choline.
By use of the Sperber technique in chickens, the renal tubule transport maximum (Tm) for the organic cation tetraethylammonium (TEA) was determined in vivo. The tubular transport rate, the Tm, and the competitor potency are assumed to have causal relationships. It was demonstrated that the two cations TEA and choline compete for the tubular transport of [14C]TEA. The saturating load of one cation was reduced by the simultaneous presence of the other. The Tm for these two cations was different by a factor of 2.4 and their respective competitor potency was inversely related to their Tm.
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D002645:Chickens; D002794:Choline / Q000378:metabolism* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D007687:Kidney Tubules, Proximal / Q000378:metabolism*; D007700:Kinetics; D013757:Tetraethylammonium Compounds / Q000378:metabolism*; D010130:p-Aminohippuric Acid / Q000378:metabolism
D013757:Tetraethylammonium Compounds; D002794:Choline; D010130:p-Aminohippuric Acid