[Lack of a cancerogenic effect after application of amines and amides together with nitrite in rabbits (author's transl)].
Young rabbits of both sexes received the following nitrosable compounds and sodium nitrite: Group 1:13 animals received 0.1 per cent methylurea in food and 0.1 per cent NaNO2 in drinking water. Two control groups of 6 rabbits were applied NaNO2 or methylurea, respectively. Duration of application 100 days. Group2: 20 animals received 0.2 per cent dimethylbenzylamine in drinking water and 0.15 per cent NaNO2 in food for 100 days. 10 control animals got only 0.2 per cent dimethylbenzylamine. Group 3: 20 rabbits were fed with 0.2 per cent diethylaminohydrochloride and 0.2 per cent NaNO2 added to the food. 10 controls received only 0.2 per cent of the amine. Duration of feeding 63 days.
D000577:Amides; D000588:Amines; D000818:Animals; D002273:Carcinogens; D004195:Disease Models, Animal; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009573:Nitrites; D011817:Rabbits
D000577:Amides; D000588:Amines; D002273:Carcinogens; D009573:Nitrites
Fehlender kanzerogener Effekt nach Gabe von Aminen bzw. Amiden und Nitrit an Kaninchen