A gene apparently determining the extent of sialylation of lysosomal alpha-mannosidase in mouse liver.
Organ-specific electrophoretic heterogeneity of lysosomal alpha-mannosidase has been observed within individual strains of inbred mice. Polymorphism between C57BL/6J and CBA/J for liver lysosomal alpha-mannosidase is determined by a single genetic locus on chromosome 5 and appears to be the result of differences in sialylation of the lysosomal enzyme. Two different patterns of expression of development of the liver electrophoretic forms have been observed.
D000818:Animals; D001921:Brain / Q000201:enzymology; D002874:Chromosome Mapping; D004186:Disaccharidases / Q000378:metabolism*; D004588:Electrophoresis, Cellulose Acetate; D005796:Genes; D008040:Genetic Linkage; D008099:Liver / Q000201:enzymology*; D008168:Lung / Q000201:enzymology; D008247:Lysosomes / Q000201:enzymology; D008361:Mannosidases / Q000378:metabolism*; D051379:Mice / Q000378:metabolism*; D008815:Mice, Inbred Strains; D009439:Neuraminidase / Q000378:metabolism*; D009928:Organ Specificity; D011110:Polymorphism, Genetic; D013154:Spleen / Q000201:enzymology
D004186:Disaccharidases; D008361:Mannosidases; D009439:Neuraminidase