[Anemia in terminal kidney failure. Pathogenesis and therapy].
Various factors are involved in the pathogenesis of anemia in dialysis patients. Reduced erythropoiesis is mainly attributed to erythropoietin deficiency. Stimulation of erythropoiesis may be promoted by androgens. Substitution of iron is recommended in case of iron deficiency. As a rule, supplementation of vitamin B12 is not necessary, but administration of folic acid is recommended. Treatment of anemia in renal failure is rendered more effective by increased technical efficiency in hemodialysis permitting a relatively protein-rich diet. Blood transfusions are not necessary during routine treatment of dialysis. Since bilateral nephrectomy will always provoke severe anemia, it should be reserved to special cases of severe hypertension. Until now, no conservative therapy has been developed which would allow optimal treatment of anemia in dialysis patients. Successful renal transplantation still is, and will be, the best therapeutic intervention.
D000728:Androgens / Q000627:therapeutic use; D000747:Anemia, Hypochromic / Q000097:blood / Q000188:drug therapy / Q000209:etiology* / Q000628:therapy; D001803:Blood Transfusion; D004912:Erythrocytes / Q000201:enzymology; D004920:Erythropoiesis; D004921:Erythropoietin / Q000627:therapeutic use; D005492:Folic Acid / Q000627:therapeutic use; D005494:Folic Acid Deficiency / Q000097:blood; D006454:Hemoglobins / Q000032:analysis; D006461:Hemolysis; D006639:Histidine / Q000627:therapeutic use; D006801:Humans; D007501:Iron / Q000097:blood / Q000627:therapeutic use; D007676:Kidney Failure, Chronic / Q000150:complications*; D006435:Renal Dialysis; D013156:Splenectomy; D014806:Vitamin B 12 Deficiency / Q000097:blood
D000728:Androgens; D006454:Hemoglobins; D004921:Erythropoietin; D006639:Histidine; D005492:Folic Acid; D007501:Iron
Anämie bei terminaler Niereninsuffizienz. Pathogenese und Therapie