title: Candida albicans infection of sternum and costal cartilages: combined operative treatment and drug therapy and 5-fluorocytosine.
abstract: Two patients with candidal sternal osteomyelitis have been successfully treated by operative debridement and adjuvant drug therapy with 5-fluorocytosine. One patient had developed postoperative candidal wound infection after sternotomy, and the other acquired candidal sternal osteomyelitis following Candida fungemia. The diagnosis, suggested by culture, was confirmed by identification of Candida pseudohyphae in debrided tissue. Histological confirmation of candidal sternal osteomyelitis indicates the need for operative debridement and specific systemic antifungal therapy. The drug 5-fluorocytosine appears to provide effective oral therapy in this situation.
mesh_terms: D002177:Candidiasis / Q000601:surgery; D002358:Cartilage, Articular; D003646:Debridement; D005437:Flucytosine / Q000627:therapeutic use; D006801:Humans; D007111:Immunity, Cellular; D008297:Male; D008875:Middle Aged; D010007:Osteochondritis / Q000188:drug therapy / Q000382:microbiology* / Q000601:surgery; D010019:Osteomyelitis / Q000188:drug therapy / Q000382:microbiology* / Q000601:surgery; D011183:Postoperative Complications / Q000188:drug therapy / Q000382:microbiology; D012272:Ribs; D013249:Sternum
chemical_list: D005437:Flucytosine