Serum levels of anticonvulsants and haematological sequelae in black epileptics.
Serum levels of phenytoin and phenobarbitone were studied in a group of Black adult epileptics. Therapeutically satisfactory levels of phenytoin were observed in only 11,3% of patients, and of phenobarbitone, in 63,9%. An overall non-compliance rate of about 50% was noted. The possible reasons for this are discussed. Folate deficiency was not a major problem in this group of patients.
D000293:Adolescent; D000328:Adult; D000368:Aged; D044383:Black People; D002648:Child; D002675:Child, Preschool; D004338:Drug Combinations; D004827:Epilepsy / Q000097:blood*; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D005492:Folic Acid / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D010634:Phenobarbital / Q000009:adverse effects / Q000097:blood*; D010672:Phenytoin / Q000009:adverse effects / Q000097:blood*; D011324:Primidone / Q000097:blood
D004338:Drug Combinations; D011324:Primidone; D010672:Phenytoin; D005492:Folic Acid; D010634:Phenobarbital