Induction of basal lamina formation in epidermal cell cultures in vitro.
Guinea-pig epidermal cells were grown on 2 types of rat collagen substrate. The cells showed the same sort of differentiation as occurs in cells growing on rigid plastic. In addition, basal lamina formed patchily at the interface with collagen. If the collagen was eroded away the basal lamina also disappeared.
D000818:Animals; D002478:Cells, Cultured; D003094:Collagen / Q000378:metabolism; D003470:Culture Media; D004847:Epithelial Cells; D004848:Epithelium / Q000378:metabolism; D006168:Guinea Pigs; D007633:Keratins / Q000096:biosynthesis; D008854:Microscopy, Electron; D051381:Rats; D012867:Skin / Q000254:growth & development* / Q000648:ultrastructure
D003470:Culture Media; D007633:Keratins; D003094:Collagen