Effects of antidepressant drugs on noradrenaline accumulation and contractile responses in the rat anococcygeus muscle.
1 The effect of a series of antidepressant drugs on noradrenaline accumulation was studied in the isolated anococcygeus muscle of the rat. 2 The most potent inhibitors of noradrenaline accumulation were nortriptyline, desipramine and protriptyline. Opipramol, trimipramine and iprindole were active only in high concentrations. 3 Contractions of the anococcygeus muscle produced by noradrenaline were strongly potentiated by nortriptyline, desipramine and protriptyline. Other uptake inhibitors were less active in potentiating the noradrenaline response. 4 Nortriptyline, in concentrations that potentiated the action of noradrenaline, reduced or abolished the response to tyramine.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D002217:Carbachol / Q000494:pharmacology; D002855:Chromatography, Thin Layer; D003864:Depression, Chemical; D004347:Drug Interactions; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects* / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism* / Q000494:pharmacology; D051381:Rats; D013997:Time Factors; D014439:Tyramine / Q000494:pharmacology
D000928:Antidepressive Agents; D002217:Carbachol; D000109:Acetylcholine; D009638:Norepinephrine; D014439:Tyramine