Decreased binding of insulin by receptors on placental membranes from diabetic mothers.
Specific binding of insulin to microsomal membranes from the placentae of insulin-dependent diabetics was significantly decreased when compared with normals. This was due to an apparent decrease in the concentration of insulin receptors.
D000328:Adult; D003920:Diabetes Mellitus / Q000378:metabolism*; D005260:Female; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance; D008861:Microsomes / Q000378:metabolism; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D011254:Pregnancy in Diabetics; D011972:Receptor, Insulin
D007328:Insulin; D011972:Receptor, Insulin