Concentrations of prostaglandin A-, E- and F-like substances in gastric mucosa of normal subjects and of patients with various gastric diseases.
1. Prostaglandin A-, prostaglandin E- and prostaglandin F-like substances were determined radioimmunologically in antral biopsy material obtained by endoscopy. 2. In patients with gastritis, the concentrations of prostaglandin (E+A)-like substances were six times as high and of prostaglandin F-like substances twice as high as in normal subjects. In chronic atrophic gastritis, the concentrations of prostaglandin (E+A)-like material was four times as high as in normal subjects whereas prostaglandin-F like material remained unchanged. In acute gastric ulcer, prostaglandin (E+A)-like material reached concentrations four times times higher than in normal subjects, accompanied by a fivefold increase of prostglandin F-like substances. After healing of the gastric ulcer, prostaglandins returned to normal values. 3. There was no correlation between gastrin and prostaglandins in all biopsy specimens.
D000328:Adult; D000368:Aged; D004381:Duodenal Ulcer / Q000378:metabolism; D005260:Female; D005753:Gastric Mucosa / Q000032:analysis*; D005755:Gastrins / Q000032:analysis; D005756:Gastritis / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D011453:Prostaglandins / Q000032:analysis*; D011454:Prostaglandins A / Q000032:analysis; D011458:Prostaglandins E / Q000032:analysis; D011460:Prostaglandins F / Q000032:analysis; D013272:Stomach Diseases / Q000378:metabolism*; D013276:Stomach Ulcer / Q000378:metabolism
D005755:Gastrins; D011453:Prostaglandins; D011454:Prostaglandins A; D011458:Prostaglandins E; D011460:Prostaglandins F