Effects of apomorphine on self-stimulation behaviour in dorsal and ventral area of lateral hypothalamus in mice.
Intraperitoneal injections of low doses of apomorphine, a dopaminergic receptor agonist, depressed briefly, and then enhanced self-stimulation behaviour in the dorsal area of lateral hypothalamus. In contrast, only depressant effects were observed in the ventral area. These differential effects suggest the presence of a dopaminergic componant in the dorsal hypothalamic self-stimulation system.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D007031:Hypothalamus / Q000187:drug effects*; D008297:Male; D051379:Mice; D012653:Self Stimulation / Q000187:drug effects*
D001058:Apomorphine