title: Stimulation of testicular protein synthesis in vivo by gonadotrophins and growth hormone in hypophysectomized adult mice.
abstract: The effects of FSH, HCG, GH and testosterone on testicular protein synthesis were investigated in hypophysectomized adult mice by measuring the incorporation of tritiated lysine into acid-precipitable material. The incorporation per mg protein was increased by FSH, HCG and GH but decreased by testosterone. The maximum effect of FSH occurred at between 8 and 14 h after administration of the hormone, much later than found in vitro for the rat.
mesh_terms: D000818:Animals; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D005640:Follicle Stimulating Hormone / Q000494:pharmacology; D006062:Gonadotropins / Q000494:pharmacology*; D013006:Growth Hormone / Q000494:pharmacology*; D007016:Hypophysectomy; D008239:Lysine / Q000378:metabolism; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D014176:Protein Biosynthesis; D013737:Testis / Q000378:metabolism*; D013739:Testosterone / Q000494:pharmacology; D013997:Time Factors
chemical_list: D006063:Chorionic Gonadotropin; D006062:Gonadotropins; D013739:Testosterone; D005640:Follicle Stimulating Hormone; D013006:Growth Hormone; D008239:Lysine