title: Preliminary trials against Biomphalaria glabrata of a new molluscicide formulation: geletin granules containing Bayluscide wettable powder.
abstract: Tests were conducted with gelatin granules containing Bayluscide (niclosamide) w.p., 23-3% w/w a.i. Granules rendered a simulated field habitat (banana drain) lethal to Biomphalaria glabrata for 40 days when applied at a rate calculated to give 5 mg/1 in the water. At this dose, Bayluscide e.c. was effective for 8-12 days. Granules exposed to various combinations of natural or simulated tropical climatic factors for up to 56 days gave variable kills of snails, apparently unrelated to the factors tested. The rate at which the molluscicide was released from the granules was affected by climatic factors: high temperatures and low humidities slowed the rate, probably by hardening the granules; rainfall and high humidities accelerated the rate, probably by softening or disintegrating the granules. There was no apparent loss of molluscicidal activity in granules exposed for 56 days to various combinations of climatic factors. The results suggest that this formulation may be applied during droughts to temporary habitats when these are dry and accessible. The molluscicide would then be released at the unpredictable start of the next wet season and kill any snails which survive the drought by aestivation.
mesh_terms: D000818:Animals; D001700:Biomphalaria / Q000187:drug effects*; D002626:Chemistry, Pharmaceutical; D005780:Gelatin; D008975:Molluscacides; D009534:Niclosamide / Q000008:administration & dosage* / Q000494:pharmacology; D014677:Pharmaceutical Vehicles; D012995:Solubility; D013997:Time Factors; D014887:Weather
chemical_list: D008975:Molluscacides; D014677:Pharmaceutical Vehicles; D009534:Niclosamide; D005780:Gelatin