Effect of flavonoids on the platelet adhesiveness in repeatedly bred rats.
Decrease of the platelet adhesiveness in rats by some flavonoids has been stated using the method of glass wool filter. The antiadhesive activity of investigated flavonoids may be ordered as follows: nobiletin greater than isorhamnetin 5,7,4'-trimethylether 3-glucoside greater than isorhamnetin 3-glucoside. Methylation of hydroxyl groups of isorhamnetin-3-glucoside markedly increases its antiadhesive activity.
D000818:Animals; D003864:Depression, Chemical; D005260:Female; D005419:Flavonoids / Q000494:pharmacology*; D066298:In Vitro Techniques; D008745:Methylation; D010973:Platelet Adhesiveness / Q000187:drug effects*; D051381:Rats; D013329:Structure-Activity Relationship
D005419:Flavonoids