Lack of hypertensive and hyperglycemic effect of diazoxide after intraventricular injection.
In adult fowls intravenous but not intraventricular injection of diazoxide produced hypotension and a rise in blood glucose concentration. Since noradrenaline microinfused into the hypothalamus produced a fall in blood pressure, it does not seem that hypotensive effects of diazoxide are mediated through release of noradrenaline in areas of the luain accessible from the ventriculus tertius cerebri. Present experiments also indicate that the hyperglycemic effects of diazoxide is unlikely to be due to an action on central adrenergic receptors.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D001794:Blood Pressure / Q000187:drug effects*; D001921:Brain / Q000187:drug effects; D002645:Chickens; D003981:Diazoxide / Q000008:administration & dosage* / Q000494:pharmacology; D007275:Injections, Intravenous; D007276:Injections, Intraventricular; D009638:Norepinephrine / Q000494:pharmacology
D001786:Blood Glucose; D003981:Diazoxide; D009638:Norepinephrine