Pentobarbital, diazepam and bemegride: their effects on open-field behavior in the gerbil (Meriones unguiculatus).
Open-field activity was measured in female mongolian gerbils treated with pentobarbital, P-barb. (15 and 20 mg/kg) or diazepam, DZP (2,4 and 8 mb/kg), either when given singly or in combination with the analeptic bemegride, BMG (20 and 40 mg/kg). The results indicated that the addition of BMG normalized certain behaviors of the gerbils treated with P-barb. and DZP. The median effective doses of BMG in inducing convulsion and death respectively were 12.0 mg/kg and 22.5 mg/kg. A mutual antagonism is apparent since no animal died after treatment with the drug combinations and seizure activity was also very much reduced.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001534:Bemegride / Q000494:pharmacology*; D001831:Body Temperature / Q000187:drug effects; D003975:Diazepam / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D005849:Gerbillinae / Q000502:physiology*; D006120:Grooming; D009043:Motor Activity / Q000187:drug effects; D010424:Pentobarbital / Q000494:pharmacology*; D012640:Seizures / Q000139:chemically induced
D001534:Bemegride; D010424:Pentobarbital; D003975:Diazepam