Effects of sex hormones on oncogenesis in rat urinary bladder by N-butyl-N-(4-hydroxybutyl)-nitrosamine.
The effects of testosterone propionate, estradiol, and estriol on the oncogenesis of male rats' bladder induced by oral administration of the carcinogen N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) were examined. There were significant differences between the testosterone propionate-administered and estradiol-administered groups and also between the testosterone propionate-administered and estriol-administered groups in the incidence of bladder tumors.
D000818:Animals; D002085:Butylhydroxybutylnitrosamine / Q000494:pharmacology*; D004347:Drug Interactions; D004958:Estradiol / Q000494:pharmacology; D004964:Estriol / Q000494:pharmacology; D012739:Gonadal Steroid Hormones / Q000494:pharmacology*; D008297:Male; D008855:Microscopy, Electron, Scanning; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology; D009602:Nitrosamines / Q000494:pharmacology*; D051381:Rats; D013739:Testosterone / Q000494:pharmacology; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced* / Q000473:pathology
D012739:Gonadal Steroid Hormones; D009602:Nitrosamines; D002085:Butylhydroxybutylnitrosamine; D013739:Testosterone; D004958:Estradiol; D004964:Estriol