title: Nonspecific test reaction for antibodies to hepatitis B surface antigen in chronic HBAg carriers.
abstract: Anti-HBs was undetectable in the plasma of 303 HBsAg-positive blood donors. The apparent reactivity of anti-HBs in the chromatographically isolated IgG fractions of these antigen-positive donors was shown to be nonneutralizable by HBsAg. The false-positive antiHBs reactions were apparently due to the isolation and concentration of IgG from the plasma which was initially nonreactive for anti-HBs.
mesh_terms: D000914:Antibodies, Viral / Q000032:analysis*; D002353:Carrier State / Q000276:immunology*; D002852:Chromatography, Ion Exchange; D005189:False Positive Reactions; D006386:Hemagglutination Tests; D006514:Hepatitis B Surface Antigens / Q000302:isolation & purification; D006801:Humans; D007074:Immunoglobulin G; D011863:Radioimmunoassay
chemical_list: D000914:Antibodies, Viral; D006514:Hepatitis B Surface Antigens; D007074:Immunoglobulin G