Cushing's syndrome associated with bronchial adenoma.
A case of Cushing's syndrome associated with a bronchial adenoma treated eight years before with bilateral adrenalectomy was cured by surgical excision of the bronchial adenoma. A discussion of clinical and hormonal features of this lesion is presented. It is concluded that this tumor manifested a capability of synthesizing and releasing substances which are chemically and biologically similar to adrenocorticotropic hormone andmelanocyte-stimulating hormone (MSH). Stimulation of the adrenal cortex by this material results in hyperplasia and hypersecretion, and stimulation of the melanocytesy MSH resulted in excessive pigmentation. Acknowledgment: We are indebted to Doctors Wendell Nicholson, David N. Orth, and Grant W. Liddle of Vanderbilt University for determinations of ACTH and MSH levels and to Mrs. E.P. Jessup for assistance in preparation of statistical data for this manuscript.
D000236:Adenoma / Q000150:complications* / Q000601:surgery; D001984:Bronchial Neoplasms / Q000150:complications* / Q000601:surgery; D003480:Cushing Syndrome / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged