Effects of spin labeled acetylcholine analogs on cholinergic receptors of the leech.
The spin labeled acetylcholine analog, SL-2, which is a potent, non-stimulating muscarinic antagonist on the isolated frog heart, is a potent agonist a low concentrations (3x10-5 M) and an antagonist at slightly higher concentrations (4.5x10-5 M) on the mixed cholinergic receptors of the leech. Ion the other hand, the spin labeled acetylcholine analog, SL-1, possesses no agonist activity while it retains the antagonist activity of SL-2. Furthermore, the spin labeled analog, SL-3, which causes hyperpolarization and a decrease in action potential frequency, exhibits neither agonist nor antagonist activity.
D000109:Acetylcholine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D066298:In Vitro Techniques; D007865:Leeches / Q000187:drug effects; D008564:Membrane Potentials / Q000187:drug effects; D011950:Receptors, Cholinergic / Q000187:drug effects*; D013113:Spin Labels; D013997:Time Factors
D011950:Receptors, Cholinergic; D013113:Spin Labels; D000109:Acetylcholine