title: Alteration of protein-binding during storage of human plasma preparations.
abstract: The influence of the storage of plasma preparations on binding was studied in different drugs. No alteration on only a slight alteration of binding was found if the plasma preparations were kept deep-frozen, or at temperatures between +3 degrees and +4 degrees C, for up to 12 months. More marked changes were found for some drugs if the plasma preparations were lyophilized or stored at +32 degrees C, for 6 and 12 months.
mesh_terms: D001793:Blood Preservation; D002746:Chlorpromazine; D005612:Freeze Drying; D005615:Freezing; D006801:Humans; D006852:Hydrochlorothiazide; D008712:Methicillin; D010113:Oxyphenbutazone; D011410:Propanidid; D011485:Protein Binding; D013390:Succinylcholine; D013412:Sulfadimethoxine; D013696:Temperature; D013752:Tetracycline; D013874:Thiopental; D013997:Time Factors
chemical_list: D006852:Hydrochlorothiazide; D013412:Sulfadimethoxine; D011410:Propanidid; D013752:Tetracycline; D010113:Oxyphenbutazone; D013390:Succinylcholine; D013874:Thiopental; D008712:Methicillin; D002746:Chlorpromazine