title: The proximal negative response and visual adaptation in the skate retina.
abstract: The proximal negative response (PNR), a complex extracellular potential derived mainly from amacrine cell activity, was studied in the all-rod retina of the skate. Tetrodotoxin (10(-6) mg/ml) did not affect either the waveform or the latency of the response, indicating that the PNR reflects the graded, nonregenerative components of the amacrine cell potential. As regards its adaptive properties, the PNR exhibited both the extreme sensitivity to weak background light and the slow time course of light and dark adaptation that are characteristic of other responses from the proximal retina. Thus, the PNR, like the b-wave and ganglion cell discharge, appears to reflect adaptive processes located within the neural network of the inner retina.
mesh_terms: D000221:Adaptation, Ocular; D000818:Animals; D003623:Dark Adaptation; D005399:Fishes / Q000502:physiology*; D008027:Light; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000502:physiology; D012160:Retina / Q000166:cytology / Q000502:physiology*; D013779:Tetrodotoxin / Q000494:pharmacology
chemical_list: D013779:Tetrodotoxin