The influence of nonspecific immunotherapy on the course of murine melanoma.
BCG, Corynebacterium parvum, vitamin A, and levamisole were continuously administered to C57 BL/6 mice bearing B16 melanoma prior to, with following tumor implantation as well as before and coincident with surgical excision of the implanted tumor. Only the group given levamisole prophylactically for 8 weeks before tumor inplantation showed a significant difference from control mice but a tenfold increase in dosage in this drug did not exert a comparable effect.
D000818:Animals; D001500:BCG Vaccine; D001428:Bacterial Vaccines / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D005260:Female; D007167:Immunotherapy / Q000379:methods*; D007978:Levamisole / Q000008:administration & dosage; D008545:Melanoma / Q000276:immunology* / Q000401:mortality; D051379:Mice; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000276:immunology; D011425:Propionibacterium acnes / Q000276:immunology; D014801:Vitamin A / Q000008:administration & dosage
D001500:BCG Vaccine; D001428:Bacterial Vaccines; D014801:Vitamin A; D007978:Levamisole