[Effect of chronic administration of carbon tetrachloride on turnover of individual RNA fractions in rat liver tissue].
During the carbon tetrachloride treatment of rats (for 24 weeks) the 5-H3-uridine content and incorporation into different rat liver RNA fractions after a short-term exposure of labeled precursor were studied. These fractions were obtained by preparative 2.5% polyacrylamide gel electrophoresis from the nuclear and cytoplasmic RNA extracted by thermal phenol fractionation. CCl4 administration resulted in a decrease in the level of transfer and ribosomal RNAs in the rat liver. Chronic CCl4 treatment led to disturbances of the turnover simultaneousness of different components of rapidly labled RNA.
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000150:complications / Q000378:metabolism*; D002467:Cell Nucleus / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000378:metabolism*; D003593:Cytoplasm / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D012313:RNA / Q000378:metabolism*; D012335:RNA, Ribosomal / Q000378:metabolism; D012343:RNA, Transfer / Q000378:metabolism; D051381:Rats; D014529:Uridine / Q000378:metabolism
D012335:RNA, Ribosomal; D012313:RNA; D012343:RNA, Transfer; D014529:Uridine
Vliianie khronicheskogo vvedeniia chetyrekhkhloristogo ugleroda na obmen otdel'nykh fraktsiĭ RNK v tkani pecheni krys