title: Intracranial aneurysms and subarachnoid hemorrhage - report on a randomized treatment study. IV-A. regulated bed rest.
abstract: Three weeks of regulated bed rest was one of four treatments evaluated in the Cooperative Aneurysm Study. A total of 187 patients with a recently ruptured intracranial aneurysm had subarachnoid hemorrhage confirmed by lumbar puncture. A group of 124 patients were assigned to treatment within 7 days after the bleed, 49 between 8 and 21 days, and 14 between 22 days and 92 days. During the mean follow-up interval of 6.5 years, mortality was 55.1%. A proved rebleed was the cause of death in 34.2%, progressive deterioration from aneurysm rupture in 8.0%, and a suspected rebleed in 4.8%. A total of 47.1% died of causes related directly to the cerebral effects of the ruptured aneurysm.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001510:Bed Rest; D002343:Carotid Artery, Internal; D002648:Child; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000150:complications / Q000401:mortality / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D013345:Subarachnoid Hemorrhage / Q000209:etiology / Q000628:therapy*