Dopamine agonists and interaction with other neurotransmitter systems.
Studies on the interaction of two dopamine (DA) agonists (selected as most specific): apomorphine (APO) and 1,3-dimethyl-5-aminoadamantane (DMAA) with serotonin (5-HT) and noradrenaline (NA) brain systems have revealed that the drugs induce the activation of 5-HT and NA neurons in an indirect way (via primary DA stimulation). These interactions are relevant for some pharmacological effects of DA agonists.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001921:Brain / Q000378:metabolism*; D008559:Memantine / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism*; D011954:Receptors, Dopamine / Q000502:physiology*; D012701:Serotonin / Q000378:metabolism*
D011954:Receptors, Dopamine; D012701:Serotonin; D001058:Apomorphine; D008559:Memantine; D009638:Norepinephrine