title: Association between HLA and red cell antigens. IV. Further studies of haemagglutinins in cytotoxic HLA antisera.
abstract: Cytotoxic HLA antisera of various specificities were examined on the AutoAnalyzer against red blood cells (RBC) from a great number of HLA-typed donors. HLA-associated haemagglutinins of different specificities were demonstrated. In cytotoxic anti-HLA-A9 and anti-HLA-A10, as well as in anti-HLA-B12, anti-HLA-Bw15 and anti-HLA-B17 sera, haemagglutinins of apparently corresponding specificities were found. This indicates that several HAL antigens may be present on RBC, but they are demonstrable only on RBC from a limited number of donors who possess the corresponding antigens on their white cells. Some antigens, like HLA-A28 and HLA-B7, are relatively strong RBC antigens, whereas others, like HLA-B12 or HLA-Bw15 seem to be much weaker. In cytotoxic anti-HLA-A1 and anti-HLA-B13 sera, no corresponding haemagglutinins were demonstrated. However, haemagglutinins of anti-HLA-B7 specificity were shown to be present in two cytotoxic anti HLA-A1 and three anti-HLA-B13 sera. No cytotoxic anti-HLA-B7 was found in these sera. Cross-reacting antibodies also seem to be frequent amoung HLA associated haemagglutinins.
mesh_terms: D000373:Agglutinins; D000941:Antigens; D001322:Autoanalysis; D003601:Cytotoxicity Tests, Immunologic; D004912:Erythrocytes / Q000276:immunology*; D006680:HLA Antigens; D006388:Hemagglutinins; D006649:Histocompatibility Antigens; D006801:Humans
chemical_list: D000373:Agglutinins; D000941:Antigens; D006680:HLA Antigens; D006388:Hemagglutinins; D006649:Histocompatibility Antigens