Inhibition of platelet adhesion to rabbit aorta by sulphinpyrazone and acetylsalicylic acid.
A technique for the isolation of rabbit thoracic aorta in a form in which it can withstand normal pressure and a new in vitro system in which it was tested is described. Segments of aorta were selectively damaged with a balloon catheter by the Baumgartneer technique and supensions of washed platelets, labelled with 51Cr, were perfused through them. More platelets adhered to the damaged surface than to the undamaged surface. Suophinpyrazone was more effective than aspirin in inhibiting platelet adherence to both the damaged and undamaged surface.
D000818:Animals; D001011:Aorta / Q000648:ultrastructure; D001241:Aspirin / Q000494:pharmacology*; D003094:Collagen / Q000494:pharmacology; D008855:Microscopy, Electron, Scanning; D010477:Perfusion; D010973:Platelet Adhesiveness / Q000187:drug effects*; D010974:Platelet Aggregation / Q000187:drug effects; D011817:Rabbits; D013442:Sulfinpyrazone / Q000494:pharmacology*
D003094:Collagen; D001241:Aspirin; D013442:Sulfinpyrazone