Inorganic fluoride nephrotoxicity: prolonged enflurane and halothane anesthesia in volunteers.
The effects of prolonged enflurane and halothane administration on urine-concentrating ability were determined in volunteers by examining their responses to vasopressin before anesthesia and on days 1 and 5 after anesthesia. A significant decrease in maximum urinary osmolality of 264 +/- 34 mOsm/kg (26 per cent of the preanesthetic value) was present on day 1 after enflurane anesthesia, whereas subjects anesthetized with halothane had a significant increase in maximum urinary osmolality of 120 +/- 44 mOsm/kg. Serum inorganic fluoride level peaked at 33.6 muM and remained above 20 muM for approximately 18 hours. Thus, the threshold level for inorganic fluoride nephrotoxicity is lower than previously suspected.
D000328:Adult; D001965:Bromides / Q000097:blood; D004737:Enflurane / Q000494:pharmacology*; D005459:Fluorides / Q000097:blood; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006221:Halothane / Q000494:pharmacology*; D006801:Humans; D007671:Kidney Concentrating Ability / Q000187:drug effects*; D008297:Male; D008738:Methyl Ethers / Q000494:pharmacology*; D009994:Osmolar Concentration; D014667:Vasopressins
D001965:Bromides; D008738:Methyl Ethers; D014667:Vasopressins; D004737:Enflurane; D005459:Fluorides; D006221:Halothane