title: [Immunologic transformation against pertussis in children following a second revaccination with ADPT-vaccine].
abstract: Immunological reconstruction was studied in children aged 6 years after the second revaccination with absorbed, pertussis-diphtheria-tetanus vaccine (APDT) in a strictly controlled trial. Antipertussis protective antibodies were determined in the sera in the passive hemagglutination test and the antigen neutralization test, whose results were characterized by the following regularities: the average (1:160--1:640) and the high (1:1280 and over) antibody titres were recorded 1 to 1.5 months after the vaccination in 46.9--48.9% of the persons vaccinated. Determination of the changes of the immunoglobulins A, M, and G at various periods after the second revaccination demonstrated that 1 to 1.5 months after the revaccination (that is at the peak of the antipertussis antibodies formation) 55.7--50.0% of the children displayed an elevation of the IgA and IgM against the background of the IgG reduction in 69.7% of cases.
mesh_terms: D000907:Antibodies, Bacterial / Q000032:analysis; D002648:Child; D006386:Hemagglutination Tests; D006801:Humans; D007115:Immunization Schedule; D007117:Immunization, Secondary; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D009500:Neutralization Tests; D010567:Pertussis Vaccine / Q000008:administration & dosage*; D013997:Time Factors; D014917:Whooping Cough / Q000276:immunology / Q000517:prevention & control*
chemical_list: D000907:Antibodies, Bacterial; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D010567:Pertussis Vaccine
vernacular_title: Osobennosti immunologicheskoĭ perestroĭki protiv kokliusha u deteĭ posle vtoroĭ revaktsinatsii AKDS-vaktsinoĭ