Effects of ascorbic acid and its 2-sulfate on rabbit aortic intimal thickening.
Effects of intravenously injected L-ascorbic acid or L=ascorbic acid 2-sulfate on aortic intimal thickening were examined histologically, qualitatively, and quantitatively in the upper, middle and lower thoracic aortic positions of cholesterol-induced atherosclerotic rabbits. A means of evaluating the degree of pathology of the aortic positions was developed employing five descriptive statistics of intimal thickening. Both L-ascorbic acid and L-ascorbic acid 2-sulfate inhibited intimal thickening. The most significant reductions were observed in the upper thoracic aorta.
D000311:Adrenal Glands / Q000378:metabolism; D000818:Animals; D001013:Aorta, Thoracic / Q000473:pathology; D001018:Aortic Diseases / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D001161:Arteriosclerosis / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D007275:Injections, Intravenous; D008099:Liver / Q000378:metabolism; D008297:Male; D011817:Rabbits; D013154:Spleen / Q000378:metabolism; D013431:Sulfates / Q000627:therapeutic use
D013431:Sulfates; D002784:Cholesterol; D001205:Ascorbic Acid