Ouabain-sensitive liver and diaphragm respiration in cold-acclimated hamster.
The in vitro respiratory rates of liver and diaphragm from hamsters were compared before and after prolonged cold exposure (5 degrees C, 3-4 wk). In the presence or absence of glucose, respiratory rates were elevated in both tissues from the cold-acclimated hamsters, and these cold-induced increases were significantly reduced by ouabain. This ouabain inhibition is consistent with the hypothesis that cold exposure of these rodents stimulates the energy demands of the Na+/K+ transport system in liver and diaphragm, with these demands providing a driving force, at least in part, for respiration and accompanying cellular thermogenesis.
D000064:Acclimatization; D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D001833:Body Temperature Regulation / Q000187:drug effects; D003080:Cold Temperature; D006224:Cricetinae; D003964:Diaphragm; D005947:Glucose / Q000378:metabolism; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism*; D008297:Male; D008566:Membranes / Q000378:metabolism; D008647:Mesocricetus; D009132:Muscles / Q000378:metabolism*; D010042:Ouabain / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects*; D011188:Potassium / Q000378:metabolism; D012964:Sodium / Q000378:metabolism
D010042:Ouabain; D012964:Sodium; D005947:Glucose; D011188:Potassium