The effect of cimetidine in meal-stimulated gastric functions measured with a new method.
A new method to measure gastric functions after meal-stimulation without infusion of bicarbonate into the stomach is presented. Six healthy volunteers were investigated after stimulation of the gastric functions with a 300-ml fluid test meal with and without cimetidine infusion. Cimetidine reduced the acid output substantially but had no effect on gastric emptying.
D000293:Adolescent; D000328:Adult; D005260:Female; D005502:Food; D005745:Gastric Acidity Determination; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006146:Guanidines / Q000494:pharmacology*; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology*; D007258:Informed Consent; D008297:Male; D008722:Methods
D006146:Guanidines; D007093:Imidazoles