title: Mesenteric and peripheral vascular ischemia secondary to ergotism.
abstract: At the present time ergotism is due primarily to excessive use or abuse of ergot preparations for migraine headaches. The diagnosis may be made with the evidence of vascular ischemia in the presence of a history of migraines and its treatment with this drug. The therapy for the vasospasm is directed chiefly at the discontinuation of the ergot preparation, with further treatment aimed at the relief of symptoms or prevention of complications. A case is presented of lower extremity ischemia with impending gangrene of both feet in a patient with a history of chronic schizophrenia. Arteriograms revealed symmetrical vasospasm in the lower extremities as well as spasm of the superior mesenteric artery and its intestinal branches. This is believed to be the first documented case of mesenteric vasospasm due to ergotism. Treatment was instituted with low molecular weight dextran, tolazoline, and reserpine with rapid and complete resolution. Caution is advised in the use of ergot preparations in neuropsychiatric disorders.
mesh_terms: D000328:Adult; D001157:Arterial Occlusive Diseases / Q000139:chemically induced / Q000209:etiology*; D003911:Dextrans / Q000627:therapeutic use; D004878:Ergotamine / Q000009:adverse effects* / Q000627:therapeutic use; D004881:Ergotism / Q000150:complications* / Q000209:etiology; D005260:Female; D005263:Femoral Artery / Q000000981:diagnostic imaging; D006801:Humans; D007383:Intermittent Claudication / Q000209:etiology; D007866:Leg / Q000098:blood supply*; D008638:Mesenteric Arteries / Q000000981:diagnostic imaging; D008881:Migraine Disorders / Q000188:drug therapy; D011859:Radiography; D012110:Reserpine / Q000627:therapeutic use; D014043:Tolazoline / Q000627:therapeutic use
chemical_list: D003911:Dextrans; D012110:Reserpine; D014043:Tolazoline; D004878:Ergotamine