title: Technetium-99m phytate as a bone-marrow imaging agent: biodistribution studies in animals: concise communication.
abstract: Technetium-99m phytate has been suggested as a bone-marrow imaging agent. This article compares the biodistribution of Tc-99m labeled "bone marrow" phytate, sulfur colloid, and diphosphonate in young rats and rabbits. Autoclaved bone marrow phytate revealed significant long-base depositon, but 96% of this activity was associated with compact bone and only 4% with bone marrow. This distribution is similar to that of diphosphonate, but significantly different from that of sulfur colloid. Technetium-99m-phytate is not recommended as a bone-marrow imaging agent.
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000378:metabolism*; D001842:Bone and Bones / Q000378:metabolism*; D003102:Colloids / Q000378:metabolism; D004164:Diphosphonates / Q000378:metabolism; D005069:Evaluation Studies as Topic; D007294:Inositol / Q000031:analogs & derivatives*; D010833:Phytic Acid / Q000378:metabolism*; D011817:Rabbits; D011877:Radionuclide Imaging / Q000379:methods*; D051381:Rats; D013455:Sulfur / Q000378:metabolism; D013667:Technetium / Q000378:metabolism*
chemical_list: D003102:Colloids; D004164:Diphosphonates; D007294:Inositol; D013455:Sulfur; D013667:Technetium; D010833:Phytic Acid