title: Metabolism of putrescine in the central nervous system.
abstract: The metabolism of putrescine in rat brain was studied systematically by the intraventricular injection of radioactive diamine. Putrescine injected into the brain was metabolized mainly to polyamines, spermidine, and spermine. A small portion of the radioactivity of putrescine was incorporated into gamma-glutamylputrescine, putreanine, gamma-aminobutyric acid, and homocarnosine. Comparison of the specific radioactivities of gamma-aminobutyric acid and homocarnosine after the injection of radioactive putrescine with those after the injection of radioactive glutamic acid indicated that there may be a metabolic pool of gamma-aminobutyric acid (putrescine-gamma-aminobutyric acid system) which is different from the glutamic acid-gamma-aminobutyric acid system and which is effectively used for synthesis of the dipeptide.
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D002336:Carnosine / Q000031:analogs & derivatives / Q000378:metabolism; D005971:Glutamates / Q000378:metabolism; D008297:Male; D011073:Polyamines / Q000378:metabolism; D011700:Putrescine / Q000378:metabolism*; D051381:Rats; D013095:Spermidine / Q000378:metabolism; D013096:Spermine / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D005971:Glutamates; D011073:Polyamines; D013096:Spermine; D005680:gamma-Aminobutyric Acid; D002336:Carnosine; D013095:Spermidine; D011700:Putrescine