[Prevention and therapy of the respiratory distress syndrome in premature infants using lecithin. Distribution of 14C--labeled lecithin after intravenous and intraamnial administration in pregnant miniature pigs?].
The aim of our researches was to point out a new therapeutical possibility to prevent a respiratory distress syndrome of prematures by application of 14C-lecithine. The experiments were carried out at Göttinger mini-pigs. Examining the placental passage it could be determined that an intravenous application was not efficient, while after intraamnial application of lecithine a rapid resorption in the fetal organism was proved. Of special interest was a high accumulation of lecithine in the fetal lung-tissue. These results indicate a possible therapeutical way to prevent a respiratory distress syndrome by lecithine substitution.
D000650:Amnion; D000818:Animals; D002250:Carbon Radioisotopes; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007267:Injections; D010713:Phosphatidylcholines / Q000008:administration & dosage* / Q000378:metabolism / Q000627:therapeutic use; D011247:Pregnancy; D011270:Pregnancy, Animal; D012127:Respiratory Distress Syndrome, Newborn / Q000517:prevention & control*; D013552:Swine
D002250:Carbon Radioisotopes; D010713:Phosphatidylcholines
Prophylaxe und Therapie des Atemnot-Syndroms bei Frühgeborenen mit Lezithin. Verteilung von 14C-markiertem Lezithin nach intravenöser und intraamnialer Applikation beim graviden Zwergschwein