Cholinergic link in the histamine-mediated increase in homovanillic acid in the rat striatum.
Administration of 500 microng of histamine into the lateral brain ventricle of the rat produced a 50% increase in striatal HVA. The DA level remained unchanged. The histamine-mediated elevation of HVA was abolished by pre-treatment with the antihistaminic drug - mepyramine. Moreover atropine significantly reduced the histamine-induced increase of HVA. It is concluded that histamine primarily activates cholinergic neurons and that the changes in DA metabolism are a consequence of an increased cholinergic activity.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D006632:Histamine / Q000494:pharmacology*; D006719:Homovanillic Acid / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D010648:Phenylacetates / Q000378:metabolism*; D011738:Pyrilamine / Q000494:pharmacology; D051381:Rats; D012737:Sex Factors
D010648:Phenylacetates; D001285:Atropine; D006632:Histamine; D011738:Pyrilamine; D004298:Dopamine; D006719:Homovanillic Acid