Lack of correlation between structural features and function of synthetic agents tested for leukocyte chemotaxis.
A number of proteins, poly-L-amino acids, oligopeptides and lipids were tested for neutrophil, eosinophil and macrophage chemotactic activity. One myoglobin preparation was active. Based on the negative findings for all other substances, primary structure, secondary structure, degree of hydrophobicity, size and charge of a molecule, could be ruled out as structural features recognized by chemotactically responding phagocytes.
D000595:Amino Acid Sequence; D000818:Animals; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D004804:Eosinophils / Q000187:drug effects; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008055:Lipids / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D008968:Molecular Conformation; D008970:Molecular Weight; D009504:Neutrophils / Q000187:drug effects; D009842:Oligopeptides / Q000494:pharmacology; D010443:Peptide Chain Termination, Translational; D010455:Peptides / Q000494:pharmacology; D011487:Protein Conformation; D011506:Proteins / Q000494:pharmacology; D011817:Rabbits; D012995:Solubility; D013329:Structure-Activity Relationship
D008055:Lipids; D009842:Oligopeptides; D010455:Peptides; D011506:Proteins