Evidence for abnormal heart induction in cardiac-mutant salamanders (Ambystoma mexicanum).
Homozygosity for simple recessive gene c in axolotl embryos results in the absence of a heartbeat. Gene c alters the morphology of the mutant anterior endoderm - the primary heart inductor.
D000557:Ambystoma / Q000196:embryology*; D000818:Animals; D004627:Embryonic Induction; D004707:Endoderm / Q000166:cytology / Q000648:ultrastructure; D005796:Genes; D006321:Heart / Q000196:embryology*; D008648:Mesoderm / Q000166:cytology; D008854:Microscopy, Electron; D009154:Mutation; D009200:Myocardial Contraction