[Effectiveness of the resorptive treatment of leptomeningitis (experimental study)].
An introduction into the major cistern of the cranial ground of sterile talc to 134 rabbits artificially created a model of leptomeningitis. The talc evoked proliferative reactions of fiber and cellular structures adjacent to the area of pia mater. Treatment by 1 or 2 sessions of lydase, pyrogenal, bijochinol, bijochinol in combination with radiation therapy led to a significant decrease of the fibroplastic changes in the pia mater and liquordynamic pyrogenal. Bijochinol therapy did not exert any special effect. The convened studies confirm the effectiveness of resorptive therapy, thus permitting to recommend this form of therapy for the treatment of patients with arachnoiditis (leptomeningitis).
D000818:Animals; D001099:Arachnoid / Q000473:pathology; D001100:Arachnoiditis / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000628:therapy*; D001921:Brain / Q000473:pathology; D005260:Female; D006821:Hyaluronoglucosaminidase / Q000627:therapeutic use; D008297:Male; D011749:Pyrogens / Q000627:therapeutic use; D011803:Quinine / Q000627:therapeutic use; D011817:Rabbits
D011749:Pyrogens; D011803:Quinine; D006821:Hyaluronoglucosaminidase
Effektivnost' rassasyvaiushchego lecheniia leptomeningita (éksperimental'noe issledovanie