title: Use of pharmacological data for bioavailability and pharmacokinetic analyses.
abstract: The use of pharmacological responses such as pupil diameter for dosage individualization, bioavailability, and pharmacokinetic analyses is becoming more widespread. Attempts to use pupil diameter to assess morphine bioavailability illuminate the fact that multiple responses, nonlinearities, and the condition of the subject can produce misleading results unless the applicability of the method is confirmed.
mesh_terms: D000818:Animals; D001682:Biological Availability; D004305:Dose-Response Relationship, Drug; D007700:Kinetics; D008297:Male; D008722:Methods; D009020:Morphine / Q000097:blood* / Q000494:pharmacology; D011680:Pupil / Q000187:drug effects*; D011817:Rabbits; D013997:Time Factors
chemical_list: D009020:Morphine