title: Induction of an intestinal epithelial sugar transport system by high blood sugar.
abstract: Intravenous infusion of glucose produces a marked increase of the mucosal-to-serosal sugar flux in the isolated everted small intestine of rats. The phenomenon is partially substrate specific, is inhibited by phloretin but not by phlorizin and is completely abolished by cycloheximide. The results suggest that sustained hyperglycemia may stimulate the synthesis of new transport receptors (carriers).
mesh_terms: D000818:Animals; D001693:Biological Transport, Active; D001786:Blood Glucose / Q000502:physiology*; D005632:Fructose / Q000378:metabolism; D005690:Galactose / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006601:Hexoses / Q000378:metabolism*; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000378:metabolism; D007421:Intestine, Small / Q000378:metabolism*; D008757:Methylglucosides / Q000378:metabolism; D051381:Rats
chemical_list: D001786:Blood Glucose; D006601:Hexoses; D008757:Methylglucosides; D005632:Fructose; D005947:Glucose; D005690:Galactose