Pharmacokinetics of fosfomycin during hemodialysis.
A study was made of the elimination of fosfomycin by the membrane of the artificial kidney in 10 patients with hemodialysis and a creatinine clearance of less than 5 ml/min. To do so we determined the half-life, the dialysance, the percentage of total loss and the percentage of loss by the artificial kidney. We reached the conclusion that fosfomycin is heavily dialyzed (D = 64 ml/min), it is entirely eliminated by the kidneys and its half-life is therefore affected very little (an increase of only about 30 min is produced). All of this leads to a practical schema by which the entire initial dose should be replenished at the end of each dialysis.
D000900:Anti-Bacterial Agents / Q000378:metabolism*; D005578:Fosfomycin / Q000008:administration & dosage / Q000378:metabolism*; D006207:Half-Life; D006801:Humans; D007668:Kidney / Q000378:metabolism; D008567:Membranes, Artificial; D006435:Renal Dialysis; D013997:Time Factors
D000900:Anti-Bacterial Agents; D008567:Membranes, Artificial; D005578:Fosfomycin