Reserpine and cerebral vasospasm.
Cerebral vasospasm was produced in the dog basilar artery by topically applied five-day-old clotted autologous blood, but not by freshly drawn blood. The spasm was reversed by methysergide, an antiserotonin agent. However, vasospasm was not produced by five-day-old clotted autologous blood from dogs pretreated with reserpine. This suggests platelet serotonin or a similar, unidentified substance as the vasospastic element in dog blood responsible for experimental vasospasm from topically applied whole blood. Other experimental data support these findings.
D000818:Animals; D001488:Basilar Artery; D004195:Disease Models, Animal; D004285:Dogs; D002546:Ischemic Attack, Transient / Q000517:prevention & control*; D008784:Methysergide / Q000494:pharmacology / Q000627:therapeutic use; D012110:Reserpine / Q000494:pharmacology / Q000627:therapeutic use*
D012110:Reserpine; D008784:Methysergide