[Modern aspects in the pathogenesis of urticaria with special reference to intolerance phenomena].
The chronic urticaria remains till now a "vexing problem" (Sheldon, 1954), because its etiopathology can be clarified only in about 20-30%. Five different immunologic mechanisms, two nonimmunologic mechanisms and two important manifestation factors are found. The physical triggering (12-17%) and the so-called aspirine/additiva provocation (26%) seem to be the most frequent causes of urticaria. Exogenic antigens are identified only in 3-8% of cases. The unspecific reaction phase of urticaria can be different too, although the degranulation of mast cells with histamine-deliberation is found very often. In hereditary urticaria and in pressure urticaria histamine-deliberation seems not to be important.
D000707:Anaphylaxis; D000937:Antigen-Antibody Reactions; D001241:Aspirin / Q000009:adverse effects; D001324:Autoantigens / Q000032:analysis; D002908:Chronic Disease; D003080:Cold Temperature; D004342:Drug Hypersensitivity; D006632:Histamine; D006633:Histamine Antagonists; D006801:Humans; D011312:Pressure; D012008:Recurrence; D014581:Urticaria / Q000209:etiology* / Q000235:genetics
D001324:Autoantigens; D006633:Histamine Antagonists; D006632:Histamine; D001241:Aspirin
Moderne Aspekte der Urtikariapathogenese unter besonderer Berücksichtigung des Intderanzphänomens