title: Correlation of single fibre EMG and muscle histochrmistry using an open biopsy recording technique.
abstract: Single fibre electromyographic (SFEMG) recordings were carried out during open muscle biopsy. Nine patients were studied, including 5 with Duchenne muscular dystrophy, 2 with spinal muscular atrophy and 1 each with limb-girdle dystrophy and myotonic dystrophy. Correlations were possible between the SFEMG fibre density determinations and histochemical evidence of grouping in some biopsies, particularly involving Type I fibres. This combined technique permits an improved assessment of the functional state of abnormal muscle.
mesh_terms: D000293:Adolescent; D000328:Adult; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D003402:Creatine Kinase / Q000097:blood; D004576:Electromyography / Q000379:methods*; D005260:Female; D006651:Histocytochemistry / Q000379:methods*; D006801:Humans; D008297:Male; D009132:Muscles / Q000473:pathology / Q000503:physiopathology; D009133:Muscular Atrophy / Q000175:diagnosis / Q000503:physiopathology; D009136:Muscular Dystrophies / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology; D009223:Myotonic Dystrophy / Q000175:diagnosis / Q000503:physiopathology; D009431:Neural Conduction; D009468:Neuromuscular Diseases / Q000175:diagnosis*
chemical_list: D003402:Creatine Kinase