Biodegradability and tissue reaction of random copolymers of L-leucine, L-aspartic acid, and L-aspartic acid esters.
A series of copoly(alpha-amino acids) with varying percentages of hydrophilic (L-aspartic acid) and hydrophobic monomers (L-leucine, beta-methyl-L-aspartate, and beta-benzyl-L-aspartate) were implanted subcutaneously in rats and the macroscopic degradation behavior was studied. Three groups of materials (A,B,C) with different ranges of hydrophilicity were distinguished: A) hydrophobic materials showed no degradation after 12 weeks; B) more hydrophilic materials revealed a gradual reduction in size of the samples, but were still present after 12 weeks; and C) hydrophilic copolymers disappeared within 24 hr. The tissue reactions caused by the materials of group A resembled that of silicone rubber, whereas those of group B showed a more cellular reaction.
D000818:Animals; D001224:Aspartic Acid / Q000378:metabolism; D001673:Biodegradation, Environmental; D004343:Drug Implants; D007930:Leucine / Q000378:metabolism; D008297:Male; D010455:Peptides / Q000378:metabolism*; D051381:Rats; D012498:Sanitary Engineering; D013997:Time Factors
D004343:Drug Implants; D010455:Peptides; D001224:Aspartic Acid; D007930:Leucine