In vitro technetium-99m red blood cell labeling using commercial stannous pyrophosphate.
A simple and rapid technique of preparing technetium-99m-labeled erythrocytes using commercial stannous pyrophosphate as the reducing agent was developed. The technique involves incubating red cells with stannous pyrophosphate, centrifugation, and addition of Tc-99m pertechnetate to the red cell fraction. A mean red cell labeling efficiency of 94% was achieved in 10 patient samples and less than 5% in vitro dissolution of Tc-99m red blood cells occurred up to two hours after preparation.
D004355:Drug Stability; D004912:Erythrocytes / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007553:Isotope Labeling / Q000379:methods*; D010710:Phosphates; D013667:Technetium / Q000097:blood; D013997:Time Factors; D014003:Tin Polyphosphates
D010710:Phosphates; D014003:Tin Polyphosphates; D013667:Technetium