Action of metergoline in suppressing prolactin release induced by mechanical breast emptying.
Ten women were studied during the first post-partum week. Mechanical breast emptying with a breast pump for 30 min induced a marked increase in plasma prolactin (PRL) reaching a maximum 30 min after the beginning of stimulation. In all patients oral administration of the antiserotonin agent metergoline, 8 mg daily for two days, completely blocked any PRL secretion induced by breast stimulation. These results confirm the inhibitory effect of metergoline on PRL release.
D000328:Adult; D001940:Breast; D004873:Ergolines / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007774:Lactation; D008711:Metergoline / Q000494:pharmacology*; D010812:Physical Stimulation; D010919:Placebos; D011247:Pregnancy; D011388:Prolactin / Q000097:blood*
D004873:Ergolines; D010919:Placebos; D008711:Metergoline; D011388:Prolactin