Adverse cardiodynamic effects of vasopressin not avoided by selective intra-arterial administration.
In this study, lysine-vasopressin, administered either as a continuous, intravenous infusion (1 unit/kh/hour) or as a selective infusion into the superior mesenteric artery (0.2 unit/minute), produced equal (25%), significant (p less than 0.05), and sustained (60 minute) reductions in portal pressure. Compared to intravenous administration, selective intra-arterial infusion of vasopressin resulted in similar reductions incardiac output (38%), myocardial contractility (23%), and coronary flow (53%). Since these adverse cardiodynamic effects were not avoided by selective intra-arterial infusion, it would appear that administration of vasopressin as a continuous infusion through a peripheral vein remains the most rapid and practical method of administering the drug.
D000818:Animals; D002302:Cardiac Output / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects*; D004285:Dogs; D006321:Heart / Q000187:drug effects*; D007263:Infusions, Parenteral; D007269:Injections, Intra-Arterial; D008236:Lypressin / Q000008:administration & dosage / Q000009:adverse effects*; D009200:Myocardial Contraction / Q000187:drug effects; D014667:Vasopressins / Q000031:analogs & derivatives*
D014667:Vasopressins; D008236:Lypressin