[Serum antibodies to cytoplasmic antigens of the human brain in patients with multiple sclerosis and amyotropic lateral sclerosis].
In order to eliminate antibodies to water soluble proteins of the human brain which were preliminary divided into 10 fractions of DEAE-cellulose, the authors studied the serum of 30 patients with disseminated sclerosis and 30 patients with lateral amyotrophical sclerosis and determined their antithymic serum activity. The antibides were detected only to protein fractions 1,2 and 10. There was a tendency towards a more frequent detection of antibodies with an increase of the severity of the disease. It was not possible to determine antibodies with an increase of the severity of the disease. It was not possible to determine any correlation between the amount of antibodies and such clinical indices as the degree of severity, duration, form of the disorder, age and sex of the patients. The cytotoxic index of the patients was significantly higher than that in normals. The authors also found a correlation between the antibodies in the serum cytoplasmatic brain proteins and antithymic activity of the same sera.
D000293:Adolescent; D000328:Adult; D000690:Amyotrophic Lateral Sclerosis / Q000276:immunology*; D000906:Antibodies / Q000302:isolation & purification; D000941:Antigens; D000961:Antilymphocyte Serum; D001921:Brain / Q000276:immunology*; D002848:Chromatography, DEAE-Cellulose; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000276:immunology*
D000906:Antibodies; D000941:Antigens; D000961:Antilymphocyte Serum
Syvorotochnye antitela k tsitoplazmaticheskim antigenam mozga cheloveka u bol'nykh rasseiannym sklerozom i bokovym amiotroficheskim sklerozom