title: Microglandular hyperplasia in vaginal adenosis associated with oral contraceptives and prenatal diethylstilbestrol exposure.
abstract: Eight cases of microglandular hyperplasia arising in vaginal adenosis are presented. Five of the patients were known to have taken oral contraceptives and a sixth was pregnant at the time the lesion was discovered; a history of prenatal exposure to diethylstilbestrol (DES) was present in 5 cases. It is important to differentiate microglandular hyperplasia, which is benign, from clear cell adenocarcinoma, which also arises in a background of vaginal adenosis.
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis; D000293:Adolescent; D000328:Adult; D002584:Cervix Uteri / Q000473:pathology; D003276:Contraceptives, Oral / Q000009:adverse effects*; D003937:Diagnosis, Differential; D004054:Diethylstilbestrol / Q000009:adverse effects*; D005260:Female; D005333:Fetus / Q000187:drug effects*; D006801:Humans; D006965:Hyperplasia; D011247:Pregnancy; D014621:Vagina / Q000473:pathology; D014623:Vaginal Diseases / Q000139:chemically induced* / Q000175:diagnosis; D014625:Vaginal Neoplasms / Q000175:diagnosis
chemical_list: D003276:Contraceptives, Oral; D004054:Diethylstilbestrol