[Toxicity of lead chloride influenced by zinc iones in cultures of mouse macrophages (authors transl)].
We analysed the toxic effect of lead chloride employing peritoneal macrophages of the mouse. Toxic effects were determined using the following parameters: viability by dye exclusion test, membrane permeability estimating release of lactate dehydrogenase and carbohydrate metabolism measuring lactate production. Our results demonstrate that Zinc iones in a concentration of 1 X 10(-5) M reduce the toxic effect of lead chloride of 2-4 X 10(-4) M.
D000818:Animals; D050260:Carbohydrate Metabolism; D002463:Cell Membrane Permeability / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002712:Chlorides; D004336:Drug Antagonism; D007773:Lactates / Q000096:biosynthesis; D007854:Lead / Q000633:toxicity*; D008264:Macrophages / Q000187:drug effects*; D051379:Mice; D010537:Peritoneum / Q000166:cytology; D015032:Zinc / Q000494:pharmacology*
D002712:Chlorides; D007773:Lactates; D007854:Lead; D015032:Zinc
Einfluss von Zink-Ionen auf die toxische Wirkung vor Bleichlorid (PbCl2) untersucht an Mäusemakrophagen in vitro