Aspirin at therapeutic concentrations does not affect 5-hydroxytryptamine uptake by platelets.
Aspirin at therapeutic concentrations does not inhibit the uptake of 5-hydroxytryptamine (5-HT) by blood platelets nor induce release of 5-HT from platelets, although platelet aggregation responses to collagen and arachidonic acid (which are dependent on platelet prostaglandin synthesis) are abolished. This does not support an earlier claim that aspirin's effects on platelet function include inhibition of 5-HT transport.
D001241:Aspirin / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D009994:Osmolar Concentration; D010974:Platelet Aggregation / Q000187:drug effects; D012701:Serotonin / Q000097:blood*; D013997:Time Factors
D012701:Serotonin; D001241:Aspirin