Displacement of bilirubin from human albumin by three diuretics.
The interaction of three diuretics with bilirubin-albumin complexes was studied using the peroxidase assay, erythrocyte uptake, and sephadex gel filtration. On a molar basis, each diuretic was as potent or more potent than sulfisoxazole in displacing bilirubin from albumin. Furosemide and ethacrynic acid, when used at the recommended dosage (1 mg/kg), would probably not produce a significant increase in free bilirubin in most infants. Chlorothiazide could introduce a significant risk to jaundiced infants because of the higher dosage required.
D001663:Bilirubin / Q000378:metabolism*; D001667:Binding, Competitive; D002740:Chlorothiazide / Q000378:metabolism; D002850:Chromatography, Gel; D004232:Diuretics / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism; D004976:Ethacrynic Acid / Q000378:metabolism; D005665:Furosemide / Q000378:metabolism; D006801:Humans; D010544:Peroxidases; D011485:Protein Binding; D012709:Serum Albumin / Q000378:metabolism*; D013444:Sulfisoxazole / Q000378:metabolism
D004232:Diuretics; D012709:Serum Albumin; D013444:Sulfisoxazole; D002740:Chlorothiazide; D005665:Furosemide; D010544:Peroxidases; D004976:Ethacrynic Acid; D001663:Bilirubin