title: The local anesthetic potency of norcocaine, a metabolite of cocaine.
abstract: The local anesthetic effects of cocaine and one of its main metabolites norcocaine, were investigated comparatively on isolated ganglion cells of the marine gastropod, Aplysia californica. During a 4-hour-period, different action potential parameters such as amplitude, duration, maximum rate of rise were observed, which demonstrated that norcocaine exhibits a higher local anesthetic potency than cocaine.
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000779:Anesthetics, Local; D000818:Animals; D003042:Cocaine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D005724:Ganglia / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D008974:Mollusca; D013997:Time Factors
chemical_list: D000779:Anesthetics, Local; D003042:Cocaine