Comparison of synemol cream and other topical corticosteroid creams using the vasoconstrictor bioassay.
The human vasoconstrictor bioassay was used to assess the potency of open applications of Synemol cream (0.025%), Diprosone cream (0.05%), Aristocort-A cream (0.5%), and Valisone cream (0.1%). Intensity of vasoconstriction was determined eight, twenty-four, and thirty-two hours after application. Results obtained from the average intensity scores of the three determinations indicated that Synemol cream (0.025%) is actually a more active compound than are Diprosone cream (0.05%), Aristocort-A cream (0.5%), and Valisone cream (0.1%), and that its activity is longer acting.
D000287:Administration, Topical; D001623:Betamethasone / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology; D001624:Betamethasone Valerate / Q000008:administration & dosage / Q000494:pharmacology; D001808:Blood Vessels / Q000187:drug effects*; D003408:Cresols / Q000008:administration & dosage / Q000494:pharmacology; D004338:Drug Combinations; D005446:Fluocinolone Acetonide / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D013997:Time Factors; D014221:Triamcinolone / Q000008:administration & dosage / Q000494:pharmacology
D003408:Cresols; D004338:Drug Combinations; D005446:Fluocinolone Acetonide; D014221:Triamcinolone; C011175:betamethasone-17,21-dipropionate; D001623:Betamethasone; D001624:Betamethasone Valerate