title: [Significance of isoenzymes in acute hepatitis and differential diagnosis of chronic forms of hepatitis].
abstract: By the determination of the aldolase, GOT and LDH isoenzymes in the plasma the stage of the acute and chronic hepatitis can be well established. The suitable use of modern statistic methods (multivariate analysis) allows the characterisation, recognition and separation of the groups of disease acute, chronic persisting, chronic aggressive hepatitis and liver cirrhosis as well as the proof of transition forms and severe courses. In acute hepatitides with protracted course under prednisolone therapy in contrast to histology already after a short time changes of the isoenzymes in the hepatic tissue and in the plasma are shown. Apparently the isoenzymes are sensitive indicators of intracellular metabolic processes.
mesh_terms: D000208:Acute Disease; D001219:Aspartate Aminotransferases / Q000097:blood; D002908:Chronic Disease; D004796:Clinical Enzyme Tests; D003937:Diagnosis, Differential; D005634:Fructose-Bisphosphate Aldolase / Q000097:blood; D006505:Hepatitis / Q000175:diagnosis* / Q000201:enzymology; D006801:Humans; D007527:Isoenzymes / Q000097:blood*; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008103:Liver Cirrhosis / Q000175:diagnosis
chemical_list: D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D005634:Fructose-Bisphosphate Aldolase
vernacular_title: Zur Bedeutung der Isoenzyme bei der akuten Hepatitis und Differentialdiagnose chronischer Hepatitisformen