Potential long-acting anticonvulsants. 1; Synthesis and activity of succinimides containing an alkylating group at the 2 position.
The synthesis of succinimide derivatives in which alkylating groups have been attached to the 2 positions of the ring or to the para position of the 2-phenyl substituent is described. The alkylating groups used were (a) alpha-haloacetyl, (b) alpha-haloacetamido, (c) maleimido, and (d) maleamyl. These compounds were prepared as potential long-acting anticonvulsants. Several of these derivatives exhibited activity against metrazole-induced seizures comparable to phensuximde, The maleimide 16 and the bromoacetamido derivative 23 exhibited a duration of action of at least 3.5 h.
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis*; D004597:Electroshock; D008297:Male; D008722:Methods; D051379:Mice; D010433:Pentylenetetrazole; D012640:Seizures / Q000139:chemically induced; D013388:Succinimides / Q000138:chemical synthesis* / Q000494:pharmacology; D013997:Time Factors
D000927:Anticonvulsants; D013388:Succinimides; D010433:Pentylenetetrazole