Decreased anticonvulsant activity of carbamazepine in 6-hydroxydopamine-treated rats.
An intraventricular injection of 6-hydroxydopamine, which produced a marked decrease of catecholamines in the forebrain, significantly lowered the electroconvulsive threshold in rats. The anticonvulsant effect of carbamazepine was also significantly reduced in the animals treated with 6-hydroxydopamine. The results are consistent with the hypothesis that brain catecholamines may play an important role in seizure susceptibility as well as in the anticonvulsant activity of carbamazepine in rats.
D000818:Animals; D000927:Anticonvulsants; D001923:Brain Chemistry / Q000187:drug effects; D002220:Carbamazepine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D004298:Dopamine / Q000032:analysis; D004597:Electroshock; D005260:Female; D006892:Hydroxydopamines / Q000008:administration & dosage / Q000494:pharmacology*; D007276:Injections, Intraventricular; D009638:Norepinephrine / Q000032:analysis; D051381:Rats; D012640:Seizures / Q000503:physiopathology; D012701:Serotonin / Q000032:analysis
D000927:Anticonvulsants; D006892:Hydroxydopamines; D012701:Serotonin; D002220:Carbamazepine; D004298:Dopamine; D009638:Norepinephrine