Tubular reabsorption and urinary excretion of acetoacetate and 3-hydroxybutyrate in normal subjects and juvenile diabetics.
The renal handling of acetoacetate (AA) and 3-hydroxybutyrate (3-HB) has been examined in 8 normal subjects and 7 insulin-treated juvenile diabetics before and after i.v. infusion of sodium DL-3-hydroxybutyrate. In both normals and diabetics and ketone bodies were reabsorbed. At low filtration rates of AA and 3-HB the reabsorption was nearly complete. With increasing filtration rate both the tubular reabsorption rate and the urinary excretion rate of AA and 3-HB increased linearly. A maximal tubular reabsorption rate could not be demonstrated. In spite of higher filtration rates of AA and 3-HB in the diabetics, the mean reabsorption percentage of either ketone body did not differ from that found in the normals.
D000090:Acetoacetates / Q000378:metabolism* / Q000652:urine; D000293:Adolescent; D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism* / Q000652:urine; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D006885:Hydroxybutyrates / Q000008:administration & dosage / Q000378:metabolism* / Q000652:urine; D007275:Injections, Intravenous; D007684:Kidney Tubules / Q000378:metabolism*; D008297:Male; D008875:Middle Aged
D000090:Acetoacetates; D006885:Hydroxybutyrates