Effect of 4-pentenoate on rat liver ornithine transcarbamylase.
The effect of 4-pentenoate on rat liver ornithine transcarbamylase was studied. No effect was found. It is concluded that the effect of 4-pentenoic acid on ornithine transcarbamylase reported by others was probably due to technical errors. Available evidence indicates that 4-pentenoate inhibits ureagenesis by interfering with mitochondrial energy metabolism, which in turn impairs mitochondrial ornithine transport or depletes mitochondrial ATP, impairing carbamyl phosphate synthesis, or both.
D000818:Animals; D005229:Fatty Acids, Monounsaturated; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology; D009954:Ornithine Carbamoyltransferase / Q000378:metabolism*; D051381:Rats; D014631:Valerates / Q000494:pharmacology
D005229:Fatty Acids, Monounsaturated; D005231:Fatty Acids, Unsaturated; D014631:Valerates; C009785:4-pentenoic acid; D009954:Ornithine Carbamoyltransferase