HLA antigens and antibody responses to measles and rubella viruses in multiple sclerosis.
Twenty-four HLA-antigens coded by loci A and B were determined serologically for 60 multiple sclerosis patients from Northern Finland. Forty-five of the patients were also typed by mixed leucocyte culture reactivity for HLA-Dw2. The only statistically significant difference in antigen frequencies in these patients compared with those in controls was the decrease of HLA-A2 among patients. Measles and rubella antibody titres in patients with and without HLA-Dw2 and HLA-B7 antigens were compared using a sensitive radioimmunoassay method. There was no difference between age- and sex-matched patient groups.
D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D000917:Antibody Formation; D005260:Female; D006680:HLA Antigens / Q000032:analysis; D006649:Histocompatibility Antigens / Q000032:analysis; D006801:Humans; D008297:Male; D008459:Measles virus / Q000276:immunology*; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000235:genetics* / Q000276:immunology; D012412:Rubella virus / Q000276:immunology*
D000914:Antibodies, Viral; D006680:HLA Antigens; D006649:Histocompatibility Antigens