Evidence for a cholinergic fiber tract connecting the thalamus with the head of the striatum of the rat.
Placement of electrolytic lesions in the zona incerta or parafascicular nucleus of the rat forebrain resulted in a marked reduction of choline acetyltransferase (ChAc) activity in the head of the striatum 2-4 weeks later. Lesions of the habenula did not cause this effect implying that concomitant destruction of the fasciculus retroflexus with the parafascicular nucleus was not responsible for the effects observed. The data suggest that there is a cholinergic fiber tract connection between the parafascicular nucleus of the thalamus and the head of the striatum in the rat forebrain.
D000818:Animals; D002795:Choline O-Acetyltransferase / Q000032:analysis; D002799:Cholinergic Fibers / Q000201:enzymology / Q000502:physiology*; D003342:Corpus Striatum / Q000166:cytology* / Q000201:enzymology; D008297:Male; D051381:Rats; D013787:Thalamic Nuclei / Q000166:cytology* / Q000201:enzymology
D002795:Choline O-Acetyltransferase