Rapid in vivo destruction of Yt(a+) erythrocytes in a recipient with anti-Yta.
A patient with anti-Cartwright (anti-Yta) is reported. Immunohematologic studies showed this antibody to be an IgG immunoglobulin that does not bind complement. A 51Cr red blood cell survival study resulted in a greatly reduced half-life of less than six hours of Yt(a+) cells. The antibody titer increased threefold after the red blood cell survival study. Determination of red cell survival is indicated when crossmatch-incompatible blood transfusion is considered.
D000906:Antibodies / Q000302:isolation & purification*; D001782:Blood Donors; D001789:Blood Group Antigens; D001787:Blood Group Incompatibility; D003165:Complement System Proteins / Q000378:metabolism; D005260:Female; D006801:Humans; D007074:Immunoglobulin G; D008875:Middle Aged; D065227:Transfusion Reaction
D000906:Antibodies; D001789:Blood Group Antigens; D007074:Immunoglobulin G; D003165:Complement System Proteins