Thermal effects from degranulation of mastcells in cutaneous mastocytosis.
Small bipsies of the skin were taken from patients with papulo-cutaneous mastocytosis. The mast cell tumours were then degranulated with compound 48/80 (250 mug/ml in saline), and with a Sorption microcalorimeter, relatively strong exothermic reactions were measured, whereas normal skin showed only 1/10th the intensity. Disodium chromoglicate (1%) had no inhibitory effect on this thermal reaction.
D002151:Calorimetry; D006358:Hot Temperature; D006801:Humans; D008407:Mast Cells / Q000187:drug effects / Q000502:physiology*; D012867:Skin / Q000187:drug effects / Q000473:pathology; D013997:Time Factors; D014582:Urticaria Pigmentosa / Q000503:physiopathology*; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D003189:p-Methoxy-N-methylphenethylamine