A comparative study of the effect of vitamin E-nicotinate and the combination of vitamin E and nicotinic acid on the hydrogen peroxide-induced platelet aggregation.
The inhibitory effect of vitamin E-nicotinate upon the hydrogen peroxide (H2O2)-induced platelet aggregation was found to be greater than that of either vitamin E alone or the combination of vitamin E and nicotinic acid. Nicotinic acid showed no inhibitory effect. It was suggested that the effect of vitamin E-nicotinate was not due to the additive effect of vitamin E and nicotinic acid produced by hydrolysis, but to the unique and distinctive property of vitamin E-nicotinate itself.
D000293:Adolescent; D006801:Humans; D006861:Hydrogen Peroxide / Q000037:antagonists & inhibitors*; D066298:In Vitro Techniques; D009539:Nicotinic Acids / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D014810:Vitamin E / Q000494:pharmacology*
D009539:Nicotinic Acids; D014810:Vitamin E; D006861:Hydrogen Peroxide