Glucocorticoid responsiveness associated with HLA-B12.
Primary open-angle galucoma (POAG) patients are more responsive to glucocorticoids, and have increased prevalences of the histocompatibility antigens HLA-B7 and HLA-B12. We report herein a comparison of in vitro cellular responsiveness to glucocorticoids and HLA classification for 25 POAG patients, and 25 individuals who respond to topical dexamethasone with intraocular pressure is greater than 31 mm. HG. (GG responders). Within both the POAG and GG groups, significantly greater responsiveness to prednisolone occurs in patients with HLA-B12 antigen. No such association occurs for patients with HLA-B7.
D000368:Aged; D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology; D005260:Female; D005901:Glaucoma / Q000276:immunology* / Q000503:physiopathology; D006680:HLA Antigens / Q000032:analysis*; D006649:Histocompatibility Antigens / Q000032:analysis*; D006801:Humans; D066298:In Vitro Techniques; D007429:Intraocular Pressure / Q000187:drug effects; D008213:Lymphocyte Activation / Q000187:drug effects*; D008297:Male; D051379:Mice; D008875:Middle Aged; D011239:Prednisolone / Q000494:pharmacology*
D006680:HLA Antigens; D006649:Histocompatibility Antigens; D003907:Dexamethasone; D011239:Prednisolone