[Genetic analysis of the synthesis of IgE and hemagglutinating antibodies in high and low responder lines (HL and LL) of mice and their hybrids].
Immune responses depend upon the dose of antigen and the line of mice. Threshold doses of antigen are lower in HL, higher in LL and intermediate in hybrids. The responses obtained in F1, F2 and backcrosses demonstrate the genetic control of the interline difference. The correlation between IgE and hemagglutinating antibodies responses suggests a common genetic control for the synthesis of the two types of antibodies.
D000373:Agglutinins / Q000032:analysis*; D000818:Animals; D000917:Antibody Formation; D003433:Crosses, Genetic; D004306:Dose-Response Relationship, Immunologic; D006388:Hemagglutinins / Q000032:analysis*; D006824:Hybridization, Genetic; D007073:Immunoglobulin E / Q000096:biosynthesis*; D051379:Mice
D000373:Agglutinins; D006388:Hemagglutinins; D007073:Immunoglobulin E
Analyse génétique de la synthèse d'anticorps IgE et hémagglutinants chez les souris sélectionnées bonnes et mauvaises productrices d'anticorps (BP et MP) et chez leurs hybrides