Effects of carbachol and nicotine injected into the cerebral ventricles on electromyogram of conscious cats.
Carbachol and nicotine injected into the cerebral ventricles produced high amplitude and fast frequency activity in the electromyogram of conscious cats. Carbachol, much more than nicotine, caused bursts of such activity spaced at irregular time intervals accompanied by marked activity in the electrooculogram. In addition carbachol, but not nicotine, caused adynamia. The effect of nicotine laster 3-5 hr, while the effect of carbachol lasted up to 6 hr. The obtained results suggest that central muscarinic and nicotinic mediations are involved in the activation of the motor efferent system.
D000818:Animals; D002217:Carbachol / Q000494:pharmacology*; D002415:Cats; D002552:Cerebral Ventricles / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004576:Electromyography; D005260:Female; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009538:Nicotine / Q000494:pharmacology*; D014202:Tremor / Q000139:chemically induced
D009538:Nicotine; D002217:Carbachol