title: [Determination of the metabolic clearance and production of estradiol in breast cancer patients at menopause].
abstract: A method for the determination of estradiol metabolic clearance rate (MCR) and production rate (PR) in blood, using radioactive isotope dilution techniques, has been described. In a group of 5 normal menopausal females and 10 menopausal patients with disseminated cancer of the breast the values of MCR and PR were not found to differ significantly, but they diminished after oophorectomy.
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000378:metabolism*; D002369:Castration; D002850:Chromatography, Gel / Q000379:methods; D004958:Estradiol / Q000096:biosynthesis / Q000378:metabolism*; D005260:Female; D006801:Humans; D008593:Menopause; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D014316:Tritium
chemical_list: D014316:Tritium; D004958:Estradiol
vernacular_title: Opredelenie metabolicheskogo klirensa i produktsii éstradiola u bol'nykh rakom molochnoĭ zhelezy v menopauze