Acidic metabolite of prednisolone.
The metabolic fate of the 17beta-ketol side chain of (21-3H) prednisolone was studied with an enzyme preparation from male golden hamster liver. The acidic metabolite of prednisolone was identified by mass spectrometry as 11beta, 17alpha,20epsilon-trihydroxy-3-oxo-1,4-pregnadien-21-oic acid. The enzyme showed substrate specificity, depending on the nature of substituent on the steroid nucleus.
D000818:Animals; D006224:Cricetinae; D008099:Liver / Q000378:metabolism*; D008297:Male; D013058:Mass Spectrometry; D011239:Prednisolone / Q000378:metabolism*; D014316:Tritium
D014316:Tritium; D011239:Prednisolone