Plasma levels and half lives of thioridazine and some of its metabolites. II. Low doses in older psychiatric patients.
Plasma-levels of thioridazine, mesoridazine, sulphoridazine and two other metabolites were determined in ten older chronic psychotic patients on thioridazine therapy. The plasma-level before the morning dose of thioridazine was the most reliable parameter for clinical studies. An intra-individual relationship between lower doses of thioridazine and plasma-levels was found. The percentage contribution of psychoactive compounds to the total sum of "thioridazine plus metabolites" ranged from 43-74%. The mean "early disappearance half-life" of thioridazine was 5 hours, and its mean "late disappearance half-life" was 26 hours.
D000368:Aged; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008875:Middle Aged; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy; D013881:Thioridazine / Q000008:administration & dosage / Q000097:blood* / Q000627:therapeutic use; D013997:Time Factors
D013881:Thioridazine