Mucociliary flow in the trachea during anesthesia with enflurane, ether, nitrous oxide, and morphine.
Tracheal mucociliary flow rates in dogs were measured with a radioactive droplet technique during thiopental anesthesia, and subsequently during enflurane, either, and nitrous oxide-morphine anesthesia on different occasions. Enflurane, at 0.6, 1.2, 1.8 MAC, produced a dose-dependent, reversible depression of mucociliary flow equal to that previously reported for halothane. Nitrous oxide-halothane and nitrous oxide-morphine depressed mucociliary flow to the same extent as halothane at equivalent MAC levels. Ether did not depress mucociliary flow significantly from the thiopental control at any MAC level.
D000769:Anesthesia, Inhalation; D000771:Anesthesia, Intravenous; D000818:Animals; D002923:Cilia / Q000502:physiology*; D004285:Dogs; D004737:Enflurane / Q000494:pharmacology; D004986:Ether / Q000494:pharmacology; D005019:Ethyl Ethers / Q000494:pharmacology; D006221:Halothane / Q000494:pharmacology; D008738:Methyl Ethers / Q000494:pharmacology; D009020:Morphine / Q000494:pharmacology; D009093:Mucus / Q000502:physiology*; D009609:Nitrous Oxide / Q000494:pharmacology; D013874:Thiopental; D014132:Trachea / Q000502:physiology*
D005019:Ethyl Ethers; D008738:Methyl Ethers; D004986:Ether; D009020:Morphine; D004737:Enflurane; D013874:Thiopental; D009609:Nitrous Oxide; D006221:Halothane