The effect of doxapram on fetal breathing in the sheep.
In five ewes of 105 to 120 days gestation intravenous doxapram (1.8 to 3.85 mg/kg) administered to the mother produced a dose-related increase in fetal breathing. This effect of doxapram might prove useful as a test of human fetal health. Fetal breathing movements could be a sensitive indication of the effects of drugs on the human fetal respiratory system.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004315:Doxapram / Q000494:pharmacology*; D005260:Female; D005333:Fetus / Q000187:drug effects*; D011247:Pregnancy; D012119:Respiration / Q000187:drug effects*; D012756:Sheep
D004315:Doxapram