"VA", a new type of erythrocyte polyagglutination characterized by depressed H receptors and associated with hemolytic anemia. I. Serological and hematological observations.
This report describes a case of persistent polyagglutinability restriced to the red blood cells, and associated with hemolytic anemia in a 20-year-old male. AIME WITH NORMAL INTERVALS. His red blood cells were weakly agglutinated by almost all adult sera. No autoagglutination was noted and the direct antihuman globulin test was negative. Polyagglutinability of his red blood cells was clearly distinguishable from T, Tn and Tk. No reaction was noted with Dolichos biflorus and peanut extracts. The cells differed from normal erythrocytes in their positive reactions with various snail agglutinins and their weak reaction with a range of anti-H reagents. There was normal aggregation by Polybrene. MN determinants were normally expressed. The symbol "VA" is roposed for this type of polyagglutination.
D000328:Adult; D000373:Agglutinins; D000743:Anemia, Hemolytic / Q000097:blood*; D001666:Binding Sites, Antibody; D004912:Erythrocytes / Q000276:immunology*; D006384:Hemagglutination; D006801:Humans; D037102:Lectins; D008297:Male
D000373:Agglutinins; D037102:Lectins