Gas-liquid chromatography of methylpentynol carbamate and its metabolite 3-methylpentyne-3,4-diol.
Procedures are described for the determination of methylpentynol carbamate in serum, either by injection into the chromatograph of diluted serum or extraction of the drug into chloroform and injection of an aliquot of the concentrated organic phase; a 4% CDMS column is used. Similar assays for measuring the metabolite 3-methylpentyne-3,4-diol in urine are reported. The methods have been used for measuring methylpentynol carbamate and its metabolite in samples from rats and dogs.
D000480:Alkynes / Q000097:blood* / Q000652:urine; D000818:Animals; D002219:Carbamates / Q000097:blood* / Q000652:urine; D002725:Chloroform; D002849:Chromatography, Gas; D002853:Chromatography, Liquid; D004285:Dogs; D006018:Glycols / Q000097:blood* / Q000652:urine; D008722:Methods; D000439:Pentanols / Q000097:blood* / Q000652:urine; D051381:Rats
D000480:Alkynes; D002219:Carbamates; D006018:Glycols; D000439:Pentanols; C014103:3-methylpentyne-3,4-diol; D002725:Chloroform; C014104:methylpentynol carbamate