title: Anti-Lu14: a Lutheran antibody defining the product of an allele at the Lu8 blood group locus.
abstract: A 'new' Lutheran-related antibody, named anti-Lu14, reacts with approximately 2.4% of random bloods. Red cells of the rare Lu:-8 phenotype are Lu:14. The data indicate, with a high probability, that the Lu 14 antigen is a product of an allele of Lu8 and that Lu14 and Lu8 comprise a third pair of alleles at the Lutheran locus. Red cells of the original Sw (a+) propositus are Lu:14. By coincidence, he has inherited two low-incidence genes. This observation may explain the discrepancy in different families concerning a possible relationship between Swa and Lutheran. Pedigree information now suggests that Swa is not a Lutheran gene.
mesh_terms: D000483:Alleles; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D006801:Humans; D007518:Isoantibodies / Q000032:analysis*; D008188:Lutheran Blood-Group System; D010375:Pedigree
chemical_list: D007518:Isoantibodies; D008188:Lutheran Blood-Group System