Fosfomycin in a traumatological department.
Fosfomycin has been used in the treatment of 99 patients suffering from varying kinds of osseous processes and divided into 2 groups, one of 60 patients who were not operated on, and another of 39 who were operated. A treatment only with fosfomycin was tried initially by intravenous infusion (8-16 g/day during 2-4 days), then by the intramuscular route (2-8 g/day during 2-6 days) and finishing with treatment by the oral route (2-4 g/day during 2-6 days). The results have been excellent, all cases progressing with no septic complications. As for secondary effects, we have had only one case in which a rash appeared at the end of treatment. Intravenous infusion has been well tolerated with no sign of phlebitis in any patient.
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002648:Child; D005260:Female; D005578:Fosfomycin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D050723:Fractures, Bone / Q000601:surgery; D006801:Humans; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000188:drug therapy*; D013530:Surgical Wound Infection / Q000188:drug therapy / Q000517:prevention & control*; D014947:Wounds and Injuries / Q000601:surgery*
D000900:Anti-Bacterial Agents; D005578:Fosfomycin