Lack of effect of calcitonin on the regulation of vitamin D metabolism in the rat.
The infusion of calcitonin into intact rats increases the accumulation of 1,25-dihydroxy-[26-27-3H]vitamin D3 from 25-hydroxy-[26,27,-3H]vitamin D3 in blood, but has no effect on thyroparathyroidectomized rats using a variety of protocols. Furthermore, the vitamin D status of the animals did not alter the results. Inasmuch as no effect of calcitonin could be found on the accumulation of other vitamin D metabolites as well as 1,25-dihydroxyvitamin D3, it is concluded that calcitonin apparently plays no direct role in the regulation of vitamin D metabolism and that the previous report of an effect of calcitonin on vitamin D metabolism in vivo is probably the result of a secondary response of the parathyroid gland.
D000818:Animals; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism; D002116:Calcitonin / Q000494:pharmacology*; D004100:Dihydroxycholecalciferols / Q000096:biosynthesis*; D006887:Hydroxycholecalciferols / Q000096:biosynthesis* / Q000378:metabolism*; D007421:Intestine, Small / Q000187:drug effects / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009928:Organ Specificity; D010280:Parathyroid Glands / Q000502:physiology; D051381:Rats; D013965:Thyroidectomy; D014808:Vitamin D Deficiency / Q000378:metabolism
D004100:Dihydroxycholecalciferols; D006887:Hydroxycholecalciferols; D002116:Calcitonin