Rapid acetylation of a dihydroxy compound by 4-(dimethylamino)pyridine catalysis: application to GLC determination of clindamycin palmitate hydrochloride.
The acetylation of clindamycin palmitate hydrochloride, preparatory to GLC assay, was accelerated greatly by the use of 4-(dimethylamino)pyridine as a catalyst. The reaction time was reduced from 2.5 hr at 100 degrees using pyridine and acetic anhydride to 30 min or less at ambient temperature upon addition of excess catalyst.
D000107:Acetylation; D002384:Catalysis; D002849:Chromatography, Gas; D002981:Clindamycin / Q000032:analysis*; D007700:Kinetics; D008722:Methods; D011725:Pyridines
D011725:Pyridines; D002981:Clindamycin