Reversal by physostigmine of clozapine-induced delirium.
Clozapine, a new antipsychotic drug without extrapyramidal side effects and with strong sedating potency, can produce acute symptoms of central anticholinergic toxicity. The authors report that physostigmine, a reversible anticholinesterase agent, which can pass the blood-brain barrier, was effective in reversing the clozapine-induced brain syndrome in two patients. Physostigmine also reduced one patient's tachycardia.
D000328:Adult; D001714:Bipolar Disorder / Q000188:drug therapy; D003024:Clozapine / Q000506:poisoning* / Q000627:therapeutic use; D003693:Delirium / Q000139:chemically induced*; D003984:Dibenzazepines / Q000506:poisoning*; D005260:Female; D006801:Humans; D008297:Male; D010830:Physostigmine / Q000627:therapeutic use*
D003984:Dibenzazepines; D010830:Physostigmine; D003024:Clozapine