title: Restrainer and cell for dermal dosing of small laboratory animals.
abstract: A versatile small animal restrainer and glass dermal dosing cell were designed for use in metabolism studies of dermally applied chemicals. Through use of the restrainer it was possible to apply a chemical to the skin of an unanesthetized rat and leave it there for hours or days without contact between the application site and the restrainer. The dermal dosing cell, when affixed to the skin of a restrained rat, formed a non-occlusive covering for the dermally applied dose and prevented contamination of excretion products by flaking of the applied dose or by desquamation of dosing site skin.
mesh_terms: D000287:Administration, Topical; D000818:Animals; D006168:Guinea Pigs; D051381:Rats; D012149:Restraint, Physical / Q000295:instrumentation / Q000662:veterinary*; D012867:Skin / Q000187:drug effects*