The effects of destruction of noradrenergic ascending ventral bundles and tetrabenazine on formation of stress-induced gastric ulcer.
The possibility that hypothalamic noradrenaline (NA) plays a role in the formation of gastric ulcers under stress via ventral bundles (VB) was examined in rats after bilateral destruction of VB. After a 3-h restraint stress ulcerative changes were observed in the stomach of sham-operated rats. NA contents in the hypothalamus and cerebral cortex decreased as compared to the respective contents before stress. The VB-lesioning inhibited the stress-induced decrease of NA in the hypothalamus. Ulcer indices in the animals 1 or 7 days after the VB-lesioning, however, did not differ from those of controls. Pretreatment of sham-operated controls with tetrabenazine enhanced the stress-induced decrease of NA in the brain, and exacerbated the gastric ulceration. VB-lesioning completely blocked these effects of tetrabenazine. It appears that the tetrabenazine-induced mobilization of hypothalamic NA via VB causes an aggravation of gastric ulceration.
D000320:Adrenergic Fibers / Q000502:physiology*; D000818:Animals; D002540:Cerebral Cortex / Q000032:analysis / Q000187:drug effects / Q000378:metabolism; D007031:Hypothalamus / Q000032:analysis / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009638:Norepinephrine / Q000032:analysis / Q000378:metabolism / Q000502:physiology*; D051381:Rats; D013276:Stomach Ulcer / Q000209:etiology* / Q000378:metabolism; D013312:Stress, Physiological / Q000150:complications* / Q000378:metabolism; D013747:Tetrabenazine / Q000494:pharmacology*
D009638:Norepinephrine; D013747:Tetrabenazine