Error in recovery rate of aminoglycosides from uraemic sera.
The recovery rate of gentamicin and tobramycin from uraemic sera was between 50 and 70% using a bioassay method which gave a 90% recovery rate from normal sera. This difference was not seen with streptomycin or kanamycin. The recovery rate from uraemic sera could be raised to clinically acceptable levels of above 80% either by using a different assay medium or by preparing standard solutions in pooled uraemic sera.
D000617:Aminoglycosides / Q000097:blood*; D001681:Biological Assay / Q000592:standards*; D005839:Gentamicins / Q000097:blood; D006801:Humans; D007612:Kanamycin / Q000097:blood; D013307:Streptomycin / Q000097:blood; D014031:Tobramycin / Q000097:blood; D014511:Uremia / Q000097:blood*
D000617:Aminoglycosides; D005839:Gentamicins; D007612:Kanamycin; D014031:Tobramycin; D013307:Streptomycin