[HL-A polymorphism and its relation to cervix neoplasms].
Twenty-three HLA antigens were investigated in 121 patients with clinical cancer as well as 188 male and 212 female controls. Patients with cervical carcinoma showed significant differences in some HLA frequencies from that of controls. Patients with cervical carcinoma showed significant differences in some HLA frequencies from that of controls. In the localized form of the neophasia HLA-A3 was decreased, HLA-A9 and B 12 were increased. In the disseminated form of cervical carcinoma HLA-A 1 were found decreased and AW 32 and B 12 increased. HLA antigens could be factors, together with others yet unknown, i.e. immune response genes, HSV-2-infection, which produce an increased susceptibility to the disease.
D000917:Antibody Formation; D000937:Antigen-Antibody Reactions; D000951:Antigens, Neoplasm / Q000302:isolation & purification; D005260:Female; D005796:Genes; D006680:HLA Antigens / Q000302:isolation & purification*; D006649:Histocompatibility Antigens / Q000302:isolation & purification*; D006801:Humans; D011110:Polymorphism, Genetic; D002583:Uterine Cervical Neoplasms / Q000276:immunology*
D000951:Antigens, Neoplasm; D006680:HLA Antigens; D006649:Histocompatibility Antigens
Der HLA-Polymorphismus und seine Beziehung zur Zervix-Neoplasie