Neurotrophic stimulation of DNA synthesis in the regenerating forelimb of the newt, Triturus.
The effect of infusions of soluble newt brain extracts on deoxyribonucleic acid (DNA) synthesis in the denervated, regenerating newt blastema has been studied. When moderate early to early regenerates are denervated for 48 hours, DNA synthesis normally drops to about 40% of that found in contralateral, innervated blastemas. Infusion of brain extract halfway through the denervation period (at 24 hours) approximately doubles the rate of DNA synthesis in denervated regenerates.
D000818:Animals; D001921:Brain / Q000502:physiology*; D004247:DNA / Q000096:biosynthesis*; D003714:Denervation; D005552:Forelimb / Q000294:innervation / Q000378:metabolism / Q000502:physiology*; D012038:Regeneration; D012455:Salamandridae / Q000502:physiology*; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors; D014562:Caudata / Q000502:physiology*
D004247:DNA; D013936:Thymidine