[Inhibitory effect of a number of substances on manifestation of the embryotoxic and teratogenic effects of methylurea and sodium nitrite].
Embryos died and a teratogenic effect followed combined intragastric administration of methylurea (MU) and sodium nitrite (SN) to rats on the 9th day of pregnancy; this was caused by the endogenous synthesis of nitroso-methylurea which produced a pathogenic action. Ascorbic acid and urotropine completely blocked the possibility of manifestation of the embryotoxic and teratogenic effect occuring after combined administration of MU and SN. Sodium sulfomate decreased the embryotoxic and partially the teratogenic effect considerably, whereas urea failed to prevent the expression of the harmful effect of MU and SN on the embryo.
D000014:Abnormalities, Drug-Induced / Q000517:prevention & control*; D000818:Animals; D001205:Ascorbic Acid / Q000627:therapeutic use; D005260:Female; D005313:Fetal Death / Q000139:chemically induced* / Q000517:prevention & control; D008431:Maternal-Fetal Exchange; D008709:Methenamine / Q000627:therapeutic use; D008782:Methylurea Compounds / Q000037:antagonists & inhibitors*; D009573:Nitrites / Q000037:antagonists & inhibitors*; D011247:Pregnancy; D051381:Rats; D013451:Sulfonic Acids / Q000627:therapeutic use; D013723:Teratogens / Q000037:antagonists & inhibitors
D008782:Methylurea Compounds; D009573:Nitrites; D013451:Sulfonic Acids; D013723:Teratogens; D008709:Methenamine; D001205:Ascorbic Acid
Tormoziashches vliianie riada veshchestv na proiavlenie ĕmbriotoksicheskogo i teratogennogo deĭstviia metilmocheviny i nitrita natriia