title: Clinical and cytogenetic observations during a six-year period in an adult with Fanconi's anaemia.
abstract: A male adult patient suffering from Fanconi's anemia is described who was diagnosed 5 years before the onset of clinical symptoms by cytogenetic findings of chromosomeinstability in a lymphocyte culture. Repeated clinical, haematological and biochemical investigations of the untreated patient have been made during the observation period of six years. In the same period of time cytogenetic studies have been carried out which show no correlation in results compared with the clinical or physical findings. Four well defined lymphocyte clones have been discovered. The patient is still under observation of the clinic and the cytogenetic department.
mesh_terms: D000328:Adult; D000367:Age Factors; D000741:Anemia, Aplastic / Q000175:diagnosis*; D002875:Chromosomes; D005199:Fanconi Anemia / Q000175:diagnosis*; D006801:Humans; D007621:Karyotyping; D008213:Lymphocyte Activation; D008297:Male; D013997:Time Factors