[Effect of sydnophen and caffeine on reflex shifts in arterial pressure arising during skeletal muscle contraction].
The influence of sydnophen (5-20 mg/kg) and of caffein (10-40 mg/kg) on the pressor reaction of the arterial pressure, provoked by contraction of skeletal muscles following stimulation of the anterior spinal cord roots (L6, L7, S1) was investigated in 17 tests set up on decerebrated non-narcotized cats. The intraveonus injection of sydnophen was attended by a fall of the arterial pressure and inhibition of the pressor reflex. Caffein reduced the intensity of the pressor reflex to a lesser extent and did not modify the initial level of the arterial pressure.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002110:Caffeine / Q000494:pharmacology*; D002415:Cats; D003655:Decerebrate State; D003864:Depression, Chemical; D009046:Motor Neurons / Q000502:physiology; D009119:Muscle Contraction; D010069:Oxadiazoles / Q000494:pharmacology*; D012018:Reflex / Q000187:drug effects*; D013116:Spinal Cord / Q000502:physiology; D013558:Sydnones / Q000494:pharmacology*
D010069:Oxadiazoles; D013558:Sydnones; C013271:sydnophen; D002110:Caffeine
Vliianie sidnofena i kofeina na reflektornye sdvigi arterial'nogo davleniia, voznikaiushchie pri sokrashchenii skeletnykh myshts