title: "Lithium non-responders" in a lithium clinic.
abstract: The present study is concerned with the outcome of long-term lithium maintenance therapy administered to 107 manic-depressive patients after more than 12 months. Nine patients failed to respond despite having met the criteria for maintenance within the therapeutic range of lithium. This group, termed "lithium non-responders", had all shown bipolar illness with gross morbidity with frequent cycles, greater than 4 per year, seven had a family history of affective illness (six bipolar). The study did not demonstarte any other clear factors common to the "non-responders" group.
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000517:prevention & control; D003692:Delayed-Action Preparations; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008094:Lithium / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged
chemical_list: D003692:Delayed-Action Preparations; D008094:Lithium