title: Influence of sunscreening agents on color stability of tablets coated with certified dyes III: FD&C Yellow No. 6.
abstract: The influence of a protective coating of six sunscreening agents (glyceryl p-aminobenzoate, benzocaine, cinoxate, homosalate, n-octyl salicylate, and amyl salicylate) upon the photostability of FD&C Yellow No. 6 used to color coat tablets was studied. The alcohol film, modified sugar-, and film-coating methods were used to apply the sunscreening agents. Tablets were exposed to 1000 foot-candles of light for various times, after which reflectance measurements and visual observations were recorded. FD&C Yellow No. 6 did not follow the Kubelka-Munk equation. The order of relative stability was FD&C Yellow No. 6 greater than erythrosine sodium (FD&C Red No. 3) greater than FD&C Blue No. 1. The greatest protection against fading was afforded by benzocaine.
mesh_terms: D001391:Azo Compounds / Q000528:radiation effects*; D002626:Chemistry, Pharmaceutical; D003116:Color; D004396:Coloring Agents / Q000528:radiation effects*; D008027:Light; D009282:Naphthalenesulfonates / Q000528:radiation effects*; D013057:Spectrum Analysis; D013473:Sunscreening Agents / Q000494:pharmacology*; D013607:Tablets
chemical_list: D001391:Azo Compounds; D004396:Coloring Agents; D009282:Naphthalenesulfonates; D013473:Sunscreening Agents; D013607:Tablets