Absorption, distribution, and excretion of 14C-meglumine in rats and dogs after administration of 14C-meglumine salicylate.
Meglumine labeled with carbon-14 was administered orally as 14C-meglumine salicylate to rats and dogs to study its distribution and excretion. The compound was incompletely absorbed; that which was absorbed was rapidly excreted in the urine. Peak blood levels were about 5-10 mug/ml in rats and 2-8 mug/ml in dogs. Tissue levels were negligible at the end of the experimental periods. No evidence for N-demethylation or oxidation to carbon dioxide was obtained.
D000818:Animals; D001646:Bile / Q000378:metabolism; D004285:Dogs; D005243:Feces / Q000032:analysis; D007408:Intestinal Absorption; D008297:Male; D008536:Meglumine / Q000378:metabolism* / Q000652:urine; D051381:Rats; D013012:Sorbitol / Q000031:analogs & derivatives*; D013997:Time Factors
D013012:Sorbitol; D008536:Meglumine