title: [Isochroman-4-spiro-4'-piperidine: synthesis and analgesic properties].
abstract: The synthesis of some isochroman-4-spiro-4'-piperidines by intramolecular O-methylation of 4-aryl-4-hydroxymethylpiperidines with formaldehyde and their analgesic activity ("hot plate"test in mice) are reported. The introduction of the new ring led to compounds with weak analgesic activity.
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis*; D000818:Animals; D001578:Benzopyrans / Q000138:chemical synthesis*; D002839:Chromans / Q000138:chemical synthesis*; D003460:Crystallization; D051379:Mice; D010880:Piperidines / Q000138:chemical synthesis*; D013141:Spiro Compounds / Q000138:chemical synthesis
chemical_list: D000700:Analgesics; D001578:Benzopyrans; D002839:Chromans; D010880:Piperidines; D013141:Spiro Compounds
vernacular_title: Isocroman-4-spiro-4'-piperidine: sintesi e proprietà analgesiche