Potential hypolipidemic agents derived from 3-hydroxy-17,17-dimethylgona-1,3,5(10),8,11,13-hexaene.
Numerous aryloxy derivatives containing a lipophilic group have been found to possess hypolipidemic activity. This has prompted the preparation of various derivatives of 3-hydroxy-17,17-dimethylgona-1,3,5(10),8,11,13-hexaene (6a). In 6a the lipophilic biphenyl group is incorporated into the steroid nucleus. A three-step synthesis of 6a from 17beta-methylestradiol methyl ether was developed. The derivatives prepared were tested in rats made hypercholesterolemic with propylthiouracil. Several were found active in this test.
D000818:Animals; D002784:Cholesterol / Q000097:blood; D002994:Clofibrate / Q000494:pharmacology; D005260:Female; D006067:Gonanes / Q000138:chemical synthesis*; D006937:Hypercholesterolemia / Q000139:chemically induced / Q000503:physiopathology; D000960:Hypolipidemic Agents / Q000138:chemical synthesis*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011441:Propylthiouracil; D051381:Rats; D014280:Triglycerides / Q000097:blood; D014599:Uterus / Q000033:anatomy & histology / Q000187:drug effects
D006067:Gonanes; D000960:Hypolipidemic Agents; D014280:Triglycerides; D011441:Propylthiouracil; D002784:Cholesterol; D002994:Clofibrate