Combined gas-liquid chromatographic-mass spectrometric analysis of pemoline in biological samples.
A description is given of a gas-liquid chromatographic (GLC) method for the detection and determination of pemoline in biological samples. On treatment with hydrochloric acid, pemoline is converted into 5-phenyl-2,4-dioxooxazolidine, an acidic compound, which can be easily extracted with dichloromethane and determined by GLC. A combined GLC-mass spectrometric method is described.
D000818:Animals; D002849:Chromatography, Gas / Q000379:methods; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods; D008832:Microchemistry; D010389:Pemoline / Q000032:analysis* / Q000097:blood / Q000652:urine
D010389:Pemoline