title: Comparative effect of intravenous administration of atenolol and practolol on resting and exercise-evoked increase in heart rate and cardiac work load in normal human subjects.
abstract: A comparative study of the intensity and duration of action of intravenously administered single doses of atenolol and practolol on the resting and exercise-evoked increase in heart rate and rate-pressure product was carried out in six normal human subjects. On a weight to weight basis, atenolol was 8 times more potent than practolol. There were only marginal differences in the intensity and duration of action of the two drugs. Atenolol, like practolol, was well-tolerated and no side effects were observed. If found safe on longterm use, atenolol may be a suitable alternative to practolol. The daily administration of atenolol in two divided doses should suffice for therapeutic purposes.
mesh_terms: D000328:Adult; D001262:Atenolol / Q000008:administration & dosage / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D005080:Exercise Test; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007275:Injections, Intravenous; D005082:Physical Exertion; D011217:Practolol / Q000008:administration & dosage / Q000494:pharmacology*; D011412:Propanolamines / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D011412:Propanolamines; D001262:Atenolol; D011217:Practolol