Deficienty of specific HLA antibodies in severe pregnancy pre-eclampsia/eclampsia.
The paradox of the survival of the foetal allograft remains unresolved as does the aetiology of pre-eclampsia/eclampsia--the principle disease of pregnancy. In a prospective study of very severe cases of pre-eclampsia we have found significantly reduced antibody to paternal histocompatibility antigens. Lowered immune response to the foetal allograft may play a role in severe cases of pre-eclampsia.
D000917:Antibody Formation; D004461:Eclampsia / Q000276:immunology*; D005260:Female; D005312:Fetal Blood / Q000276:immunology; D006680:HLA Antigens / Q000032:analysis*; D006649:Histocompatibility Antigens / Q000032:analysis*; D006801:Humans; D011225:Pre-Eclampsia / Q000276:immunology*; D011247:Pregnancy
D006680:HLA Antigens; D006649:Histocompatibility Antigens