The utilization of a new strength citrate anticoagulant during centrifugal plateletpheresis. II. Assessment of in vitro platelet function.
Platelets contained in concentrates prepared by intermittent flow centrifugation utilizing 5.0 g total ionized citrate, function normally as assessed by tests for adhesion, spreading, and ADP and collagen-induced aggregation. The ability of platelets to adhere and to aggregate following incubation with ADP is significantly reduced, in samples taken immediately after the collection procedure. Total platelet collection and platelet collection efficiency, is not compromised by use of the above citrate concentration.
D000925:Anticoagulants; D001792:Blood Platelets / Q000502:physiology*; D002469:Cell Separation; D002498:Centrifugation; D002951:Citrates; D005112:Extracorporeal Circulation; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D010956:Plasmapheresis / Q000379:methods*; D010973:Platelet Adhesiveness; D010974:Platelet Aggregation
D000925:Anticoagulants; D002951:Citrates