Cardiovascular and neuromuscular effects of dimethyl sulfoxide in anesthetized rabbits.
In rabbits anesthetized with pentobarbital, the carotid arterial blood pressure and bilateral contractions of the gastrocnemius muscles due to electrical stimulation of the sciatic nerves were recorded. Intravenous administration of up to 1 ml of dimethyl sulfoxide/kg caused profound hypotension and eventually failure of neuromuscular transmission. Caution must be used in considering dimethyl sulfoxide as a solvent for drug administration.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004121:Dimethyl Sulfoxide / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects*; D009119:Muscle Contraction / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects*; D011817:Rabbits; D012119:Respiration / Q000187:drug effects
D004121:Dimethyl Sulfoxide