[Effect of dibazol on cerebral blood supply and EEG in experimental intracerebral hemorrhage].
A hemorrhage into the right internal capsule in vigilant cats is accompanied by a drop of focal cerebral blood flow in the sensomotor cortex, in the thalamus and reticular formation of the middle brain of both hemispheres, an appearance of slow-wave high amplitude in the EEG activity and in some cases of convulsive discharges. Such changes of the blood flow and bioelectrical activity are preserved in survived cats after 24 hours following hemorrhage. An intracarotid singular injection (Img/kg) and especially a 30 minute infusion of 0.5% solution of dibasol brings about in most of the cases an increase of the blood flow in the studied brain structures, and is accompanied by a partial normalization of bioelectrical activity.
D000818:Animals; D001562:Benzimidazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D001921:Brain / Q000503:physiopathology; D002339:Carotid Arteries; D002543:Cerebral Hemorrhage / Q000188:drug therapy* / Q000503:physiopathology; D003342:Corpus Striatum; D004569:Electroencephalography; D005260:Female; D007269:Injections, Intra-Arterial; D008297:Male; D009044:Motor Cortex / Q000098:blood supply; D010276:Parasympatholytics / Q000627:therapeutic use*; D012154:Reticular Formation / Q000098:blood supply; D013003:Somatosensory Cortex / Q000098:blood supply; D013788:Thalamus / Q000098:blood supply
D001562:Benzimidazoles; D010276:Parasympatholytics; C004453:bendazole
Vliianie dibazola na krovosnabzhenie golovnogo mozga i EEG pri éksperimental'nom vnutrimozgovom krovoizliianiĭ