Homeostasis during hypoglycemia: central control of adrenal secretion and peripheral control of feeding.
Intravenous infusions of manose or B-hydroxybutyrate, metabolic fuels which can be oxidized by brain, abolished adrenal discharge of epinephrine in rats during insulin-induced hypoglycemia, whereas infusion of fructose, a sugar which does not cross the blood-brain barrier, did not. In contrast, increased feeding behavior during hypoglycemia was prevented both by the sugars and by B-hydroxybutyrate. Thus, while the sympathetic response during marked hypoglycemia may have been initiated by alterations in cerebal metabolism, the feeding response evidently was not, and a decrease in the utilization of glucose per se does not appear to be the critical stimulus in either case.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D002395:Catecholamines / Q000097:blood*; D005247:Feeding Behavior / Q000187:drug effects / Q000502:physiology*; D005632:Fructose / Q000494:pharmacology; D005947:Glucose / Q000494:pharmacology; D006706:Homeostasis; D006885:Hydroxybutyrates / Q000494:pharmacology; D007003:Hypoglycemia / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D008358:Mannose / Q000494:pharmacology; D051381:Rats
D001786:Blood Glucose; D002395:Catecholamines; D006885:Hydroxybutyrates; D005632:Fructose; D005947:Glucose; D008358:Mannose