[Effect of quaterone on mitochondrial monoamine oxidase activity in different zones of the stomach in neurodystrophy of its wall].
New data have been made available which confirm the existence of differing quateron sensitivity of tissular monaminoxidases possessing dissimilar substrate specificity. An experimental neurogenic dystrophy of the stomach is attended on the whole by an activated deamidization of monamines, but there could be seen marked differences in the ability to intensify oxidation depending upon the localization of the mitochondrial monaminoxidases in various parts of the stomach. When introduced to intact animals in a dose of 5 mg/kg quateron tends to lower the activity of mitochondrial monaminoxidases in individual receptor areas of the stomach with respect to norepinephrine and, especially, serotonin. In such instances preliminary introduction of quateron prevents an activated oxidation of norepinephrine and serotonin, observed 24 hours after inflicting an injury. In the mechanisms governing deposition of catecholamines and serotonin in the gastric wall occurring under the effect of quateron a definite role plays also the inhibition of the mitochondrial monaminoxidases.
D000818:Animals; D001565:Benzoates / Q000627:therapeutic use; D008928:Mitochondria / Q000201:enzymology*; D008995:Monoamine Oxidase / Q000378:metabolism*; D000644:Quaternary Ammonium Compounds / Q000627:therapeutic use*; D051381:Rats; D013270:Stomach / Q000201:enzymology* / Q000648:ultrastructure; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000201:enzymology
D001565:Benzoates; D000644:Quaternary Ammonium Compounds; C008342:quateron; D008995:Monoamine Oxidase
Vliianie kvaterona na aktivnost' mitokhondrial'nykh monoaminoksidaz razlichnykh zon zheludka pri neĭrodistrofii ego stenki