[Effects of nitrogen dioxide on alveolar macrophages surviving in the gas phase. A new experimental model for the study of in vitro cytotoxicity of toxic gases (author's transl)].
Alveolar macrophages surviving in the gas phase were exposed to concentrations of NO2 (0.1, 1 and 2 ppm) for 30 minutes. The exposed cells showed morphological changes, a decrease in bactericidal activity and a reduction of the ATP content. The severity of these changes is related to NO2 concentration. This new experimental model offers new possibilities for studies on the cytotoxicity of gases.
D000255:Adenosine Triphosphate / Q000032:analysis; D000818:Animals; D002470:Cell Survival; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008264:Macrophages / Q000032:analysis / Q000187:drug effects* / Q000502:physiology; D009585:Nitrogen Dioxide / Q000633:toxicity*; D011650:Pulmonary Alveoli / Q000166:cytology*
D000255:Adenosine Triphosphate; D009585:Nitrogen Dioxide
Effets du bioxyde d'azote sur les macrophages alvéolaires en survie en phase gazeuse. Un nouveau modèle expérimental pour l'étude in vitro de la cytotoxicité des gaz nocifs