[The distribution of antibiotics in extravascular renal tissue during experimental pyelonephritis of dogs (author's transl)].
For the success of an antibiotic therapy in pyelonephritis the concentration of antibiotics attainable in the kidney tissue is of extreme importance. Therefore in dogs, besides serum level and urin level a tissue level was defined after a single dose of gentamycin and cefazolin. While gentamycin is highly concentrated in the kidney, which is indeed more in a state of shock than health, Cefalozin is being excreted, after initially high values, excreted in a course approximately parallel to the blood level curve, within 5 h down to concentrations between 1 mcg/ml and 4 mcg/ml. The level of the tissue in the cortex of healthy kidneys and infected kidneys without additional damage by a ureter ligature averaged about 40% less than the serum level. The tissue level of kidneys infected by the additional damage of a ureter ligature and with signs of a pyelonephritis was extremely lower and reached occasionally hardly 20% of the serum level. Attention is also called  to the consequence of these results for the therapy of the pyelonephritis.
D000818:Animals; D001682:Biological Availability; D002437:Cefazolin / Q000378:metabolism* / Q000627:therapeutic use; D002511:Cephalosporins / Q000378:metabolism*; D004285:Dogs; D005839:Gentamicins / Q000378:metabolism* / Q000627:therapeutic use; D007668:Kidney / Q000378:metabolism*; D011704:Pyelonephritis / Q000188:drug therapy / Q000378:metabolism; D013810:Therapeutic Equivalency
D002511:Cephalosporins; D005839:Gentamicins; D002437:Cefazolin
Experimentelle Untersuchungen über Antibioticaspiegel im extravasalen Gewebe der Nieren