A study of tobacco carcinogenesis. XV. Effects of N'-nitrosonornicotine and N'-nitrosoanabasine in Syrian golden hamsters.
N'-Nitrosonornicotine (NNN) and N'-nitrosoanabasine (NAB) were synthesized and injected subcutaneously three times weekly in male and female Syrian golden hamsters for 25 weeks (total dose 375 mg). N-Nitrosopiperidine (NPD) served as positive control (total dose 150 mg). Within 83 weeks 12 out of 19 hamsters given NNN had developed tracheal tumors, 1 had a carcinoma of the nasal cavity. During the same time none of the hamsters given NAB developed tumors, whereas all 20 hamsters given NPD developed tracheal tumors and about 50% had additional neoplasms in the nasal cavity. Under the described conditions and in comparison to NPD, NNN appears to be a moderately active tumorigenic agent in the upper respiratory tract of Syrian hamsters, whereas NAB is inactive.
D000691:Anabasine / Q000031:analogs & derivatives / Q000633:toxicity*; D000818:Animals; D006224:Cricetinae; D005260:Female; D008297:Male; D008647:Mesocricetus; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009538:Nicotine / Q000031:analogs & derivatives* / Q000633:toxicity; D009602:Nitrosamines / Q000633:toxicity*; D009669:Nose Neoplasms / Q000139:chemically induced*; D010880:Piperidines / Q000633:toxicity*; D010947:Plants, Toxic; D012907:Smoking / Q000150:complications*; D014026:Nicotiana; D014134:Tracheal Neoplasms / Q000139:chemically induced*
D009602:Nitrosamines; D010880:Piperidines; C010257:N'-nitrosoanabasine; D009538:Nicotine; D000691:Anabasine; C008655:N'-nitrosonornicotine