[The course of Jones-mote reaction in guinea pigs after the sensitization with mycobacteria (author's transl)].
Mycobacterial antigens induce of JONES-MOTE reaction, which is well stated in 7 to 9 days after being intracutaneously sensitized (Tab. 1). The reaction is adjuvant independent; Al(OH)3 as an adjuvant stabilizes and enlarges the reaction in the interval between 7 and 9 days after the sensitization (Tab 2). The erythema size, read 6, 24 and 48 hours after the intradermal testing shows no significant differences (Tab. 3). The maximal intensity of the JONES-MOTE reaction was found after 24 hours (Tab. 4). The sensitization with 0.2 mg of bacterial mass is sufficient (Tab. 5, Fig. 1). The size of erythema increases when 0.5 mug to 10 mug of homologous sensitin are used (Tab. 6, Fig. 2). An oral application of M. fortuitum increased the total count of basophilic leukocytes and caused cross reactions (Fig. 3).
D000276:Adjuvants, Immunologic; D000818:Animals; D001491:Basophils / Q000276:immunology; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed; D007428:Intradermal Tests; D007958:Leukocyte Count; D009164:Mycobacterium Infections / Q000276:immunology*; D009170:Nontuberculous Mycobacteria / Q000276:immunology; D013997:Time Factors
D000276:Adjuvants, Immunologic
Verlauf der Jones-Mote-Reaktion bei Meerschweinchen nach der Sensibilisierung mit Mykobakterien