Host-parasite relationships in the yeastlike form of Paracoccidioides brasiliensis strain IVIC Pb9.
The yeastlike form of Paracoccidioides brasiliensis strain IVIC Pb9 reduced the amount of alpha-1,3-glucan in its cell wall from 45 to 3% when subcultured in vitro for several years. This strain regained its alpha-1,3-glucan up to 25% of the total cell wall when grown in vivo. A mutant strain of P. brasiliensis Pb9, named IVIC Pb140, reported to have 1,3-mannan instead of alpha-glucan in the cell wall, could not be recovered from experimentally infected animals. The existence of some relationship between the presence of alpha-1,3-glucan in the cell wall of the yeastlike form and the pathogenicity of this fungus is suggested in this report.
D000818:Animals; D002473:Cell Wall / Q000032:analysis; D006224:Cricetinae; D005658:Fungi / Q000472:pathogenicity*; D005690:Galactose / Q000032:analysis; D005944:Glucosamine / Q000032:analysis; D005947:Glucose / Q000032:analysis; D008297:Male; D008358:Mannose / Q000032:analysis; D010228:Paracoccidioides / Q000032:analysis / Q000472:pathogenicity*; D011134:Polysaccharides / Q000032:analysis; D013045:Species Specificity
D011134:Polysaccharides; D005947:Glucose; D005944:Glucosamine; D008358:Mannose; D005690:Galactose