Uptake of uric acid by separated renal tubules of the rabbit. II. Effects of drugs.
The effect of various drugs on the rate of uptake of uric acid by separated renal tubules of the rabbit was investigated. Determinations were made of 150 values and slopes of the inhibition curves. The most potent inhibitor of uric acid uptake was sulfinpyrazone, with an 150 of 0.02 mM. Calcium ipodate and benzbromarone were also potent inhibitors. Uricosuric drugs, with the exception of benzbromarone, had shallow inhibition slopes. Diuretic drugs had steep inhibition slopes. More than one mechanism of action is probably involved in the inhibition of uric acid uptake in separated renal tubules by drugs.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D003287:Contrast Media / Q000494:pharmacology; D003864:Depression, Chemical; D004232:Diuretics / Q000494:pharmacology; D066298:In Vitro Techniques; D007684:Kidney Tubules / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D011817:Rabbits; D014527:Uric Acid / Q000378:metabolism*; D014528:Uricosuric Agents / Q000494:pharmacology
D003287:Contrast Media; D004232:Diuretics; D014528:Uricosuric Agents; D014527:Uric Acid