[Effect of nonachlazine on the frequency and amplitude of isolated atrium contraction].
The effect of nonachlazine, a new antianginal drug, on the rate and the amplitude of contractions of the isolated auricle was studied on guinea pigs and albino rats. Unlike the experiments conducted on intact animals, in the experiments on the isolated auricle nonachlazine proved to decrease the above-mentioned indices. This effect of the drug in the case of the isolated auricle is likely to be due to the ability of nonachlazine to cause a direct effect on the myocardium and the conductive heart system. No specific distinctions in the character of nonachlazine action were revealed.
D000818:Animals; D003864:Depression, Chemical; D006168:Guinea Pigs; D006325:Heart Atria; D006339:Heart Rate / Q000187:drug effects*; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects*; D010640:Phenothiazines / Q000494:pharmacology*; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats
D010640:Phenothiazines; D010879:Piperazines
Vliianie nonakhlazina na chestotu i amplitudu sokrashcheniĭ izolirovannogo predserdiia