The roles on intraluminal oxygen and glucose in the protection of the rat intestinal mucosa from the effects of ischaemia.
Rat ileal loops were subjected to 15 minutes ischaemia by clamping both mesenteric and collateral vessels, after which the functional capacity of their mucosae was assessed according to their ability to accumulate phenylalanine "in vitro". Groups of intestines were rinsed before being subjected to ischaemia. Independent and additive protective effects were observed when the rinsing buffer was oxygenated and/or when it contained glucose. Indeed, an oxygenated, glucose-containing buffer afforded full protection to the mucosa, whereas a nitrogenated, glucose-free buffer had no action.
D000818:Animals; D004347:Drug Interactions; D005947:Glucose / Q000378:metabolism / Q000494:pharmacology*; D007082:Ileum / Q000098:blood supply* / Q000187:drug effects; D066298:In Vitro Techniques; D007408:Intestinal Absorption / Q000187:drug effects; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000378:metabolism; D007511:Ischemia / Q000378:metabolism / Q000503:physiopathology*; D009584:Nitrogen / Q000494:pharmacology; D010100:Oxygen / Q000494:pharmacology*; D010649:Phenylalanine / Q000378:metabolism; D051381:Rats
D010649:Phenylalanine; D005947:Glucose; D009584:Nitrogen; D010100:Oxygen