Triamcinolone-induced wasting disease in young mice.
Young mice were treated for up to 8 weeks with daily graded doses of triamcinolone diacetate. The body weights of treated, placebo and nontreated animals were measured daily throughout the experimental period, calculated and analysed. By the first injections, significant decrease was noted in the body weight of all experimental mice regardless of their sex or initial bodyweight. The latter was followed by a so-called 'steady state' which longed for approximately 4 weeks. Marked deterioration and mortality also occurred but became severe from the fifth week of triamcinolone administration. Possible explanations for the above findings are discussed.
D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004614:Emaciation / Q000139:chemically induced*; D005260:Female; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D012737:Sex Factors; D013997:Time Factors; D014221:Triamcinolone / Q000008:administration & dosage / Q000633:toxicity*
D014221:Triamcinolone