title: Drinking following intracarotid infusions of hypertonic solutions in dogs.
abstract: Eight dogs were prepared with bilateral carotid loops and trained to stand quietly in a modified Pavlov stand. In each of the dogs, 0.3, 0.45, and 0.6 M NaCl were infused, split between the two carotids at a rate of 0.6 ml-kg-1-min-1 for 10 min and the effect on drinking assessed. A graded increase in drinking was obtained with increased osmolality of the saline (R = 0.59, N = 32, P less than 0.001). Infusion of 0.3 M NaCl was associated with an increase in jugular venous osmolality, but no significant increase in systemic osmolality. Intravenous infusion of 0.3 M NaCl at 0.6 ml-kg-1-min-1 had no effect on drinking. Intracarotid infusion of 0.3 M sucrose in 0.15 M NaCl stimulated drinking to a similar extent as 0.3 M NaCl, whereas intracarotid 0.3 M urea in 0.15 M NaCl had no effect. Increasing the systemic plasma osmolality by infusing 1.04 M NaCl intravenously stimulated drinking, an effect which was abolished by removing the central osmotic stimulus with intracarotid infusions of water. These results are compatible with a central osmoreceptor theory of thirst.
mesh_terms: D000818:Animals; D001769:Blood; D001921:Brain / Q000098:blood supply; D002339:Carotid Arteries; D004326:Drinking / Q000187:drug effects*; D006982:Hypertonic Solutions / Q000494:pharmacology*; D007263:Infusions, Parenteral; D008297:Male; D009994:Osmolar Concentration; D012462:Saline Solution, Hypertonic; D011984:Sensory Receptor Cells / Q000502:physiology; D012964:Sodium / Q000097:blood; D013395:Sucrose / Q000008:administration & dosage / Q000494:pharmacology; D014508:Urea / Q000008:administration & dosage / Q000494:pharmacology; D014867:Water
chemical_list: D006982:Hypertonic Solutions; D012462:Saline Solution, Hypertonic; D014867:Water; D013395:Sucrose; D014508:Urea; D012964:Sodium