title: A rapid, high-yield conversion of codeine to morphine.
abstract: Brief treatment of codeine (1) in chloroform with boron tribromide has consiste-tly given morphine (2) in 90-91% yield after a simple isolation procedure. The yield and simplicity of operation in this method are vastly superior to those previously reported for this transformation.
mesh_terms: D001896:Boron Compounds; D003061:Codeine; D008722:Methods; D009020:Morphine / Q000138:chemical synthesis*; D013997:Time Factors
chemical_list: D001896:Boron Compounds; D009020:Morphine; D003061:Codeine