Polarographic study of new antibacterial isoxazolium salts: 2,3-dialkyl-5-arylisoxazolium perchlorates.
The polarographic reduction of new antibacterial 2,3-dialkyl-5-arylisoxazolium salts is described. The electrode process involves an irreversible two-electron transfer and is pH independent within the 6.0-10.0 range. In more acidic media, hydrogen waves are observed; at higher pH values, a chemical degradation of the isoxazolium salt proceeds. Values of the half-wave potential of the salts are dependent on the polar contribution of the 5-aryl substituents in terms of the Hammett equation. The in vitro minimum inhibitory concentrations of these compounds are best correlated with Hansch PI values.
D000900:Anti-Bacterial Agents; D055598:Chemical Phenomena; D002621:Chemistry; D007555:Isoxazoles / Q000494:pharmacology; D010080:Oxazoles / Q000494:pharmacology; D010084:Oxidation-Reduction; D011048:Polarography; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D007555:Isoxazoles; D010080:Oxazoles