Synthesis of N-acetyl-muramyl-L-alanyl-D-isoglutamine, an adjuvant of the immune response, and of some n-acetyl-muramyl-peptide analogs.
A relatively easy synthetic method is reported for the production of the immunoadjuvant glycopeptide, N-acetyl-muramy-L-alanyl-D-isoglutamine (MDP). Most of the details in this method were also applied to the preparation of some analogs, that were synthesized in order to study structure-activity relationships.
D000276:Adjuvants, Immunologic / Q000138:chemical synthesis*; D006020:Glycopeptides / Q000138:chemical synthesis* / Q000276:immunology; D008722:Methods; D010457:Peptidoglycan / Q000276:immunology
D000276:Adjuvants, Immunologic; D006020:Glycopeptides; D010457:Peptidoglycan