Intravascular hemolysis, thrombocytopenia, leukopenia, and circulating immune complexes after jejunal-ileal bypass surgery.
Two years after jejunal-ileal bypass surgery for obesity, a 25-year-old man developed intravascular hemolysis, thrombocytopenia, and neutropenia. The patient's erythrocytes were coated with complement components (C4/C3) and his serum induced complement-dependent immune lysis of chromium-51-labeled platelets. Serum [125I]-C1q binding activity (a measure of the presence of immune complexes) was increased, and serum C4 and C3 hemolytic titers were depressed. Immune complex-mediated complement activation apparently accounted for the blood cell destruction in this patient.
D000328:Adult; D000936:Antigen-Antibody Complex; D001168:Arthritis / Q000209:etiology / Q000276:immunology; D001792:Blood Platelets; D002860:Chromium Radioisotopes / Q000378:metabolism; D003176:Complement C3 / Q000172:deficiency; D003181:Complement C4 / Q000172:deficiency; D003298:Coombs Test; D006461:Hemolysis; D006801:Humans; D007082:Ileum / Q000601:surgery*; D007583:Jejunum / Q000601:surgery*; D007970:Leukopenia / Q000175:diagnosis*; D008297:Male; D009503:Neutropenia / Q000209:etiology; D009765:Obesity / Q000628:therapy; D011183:Postoperative Complications / Q000175:diagnosis*; D012156:Reticulocytes; D013921:Thrombocytopenia / Q000175:diagnosis*
D000936:Antigen-Antibody Complex; D002860:Chromium Radioisotopes; D003176:Complement C3; D003181:Complement C4