[The effect of Partusisten on the maternal and fetal metabolism, acid-base balance and blood gases intrapartum (author's transl)].
Following i.v. injection of 50 g of Partusisten into the mother there occurs, already within 5 min., a rise in the lactate concentration which reaches its peak after 25--30 min. After 25 min, a similar can be shown in the fetus. The fetal pO2 at this time has risen significantly to 2.1 mmHg, while the pCO2 has fallen by 3 mmHg. The increase in lactate concentration both in mother and fetus alters the acid base balance in both. pH is reduced and base deficit is raised, parallel in mother and fetus. The fetal acidosis is probably due to a lactate infusion from the mother.
D000136:Acid-Base Equilibrium / Q000187:drug effects*; D002245:Carbon Dioxide / Q000097:blood; D004983:Ethanolamines / Q000627:therapeutic use*; D005260:Female; D005280:Fenoterol / Q000627:therapeutic use*; D005312:Fetal Blood / Q000032:analysis; D006801:Humans; D007743:Labor, Obstetric; D007773:Lactates / Q000097:blood; D008431:Maternal-Fetal Exchange / Q000187:drug effects*; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D011247:Pregnancy; D011773:Pyruvates / Q000097:blood; D013997:Time Factors
D004983:Ethanolamines; D007773:Lactates; D011773:Pyruvates; D002245:Carbon Dioxide; D005280:Fenoterol; D010100:Oxygen
Einwirkung auf den maternen und fetalen Stoffwechsel, Süre-Basen-Haushalt und die Blutgase bei dem therapeuti-schen Einsatz von Partusisten unter der Geburt