Mechanisms of gentamicin resistance in Staphylococcus aureus.
Three clinical isolates of Staphylococcus aureus resistant to gentamicin and other aminoglycosides have been examined for antibiotic modifying enzymes. The strains contain a number of these enzymes, most of them similar to those commonly found in aminoglycoside-resistant gram-negative strains. All three strains (and a transductant derived from one of them) contain two enzymes mediating gentamicin resistance, an aminoglycoside 6'-N-acetyltransferase and a novel enzyme, gentamicin phosphotransferase.
D000217:Acyltransferases / Q000378:metabolism; D000617:Aminoglycosides / Q000378:metabolism; D002474:Cell-Free System; D055598:Chemical Phenomena; D002621:Chemistry; D004352:Drug Resistance, Microbial; D005839:Gentamicins / Q000494:pharmacology*; D010770:Phosphotransferases / Q000378:metabolism; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000201:enzymology
D000617:Aminoglycosides; D005839:Gentamicins; D000217:Acyltransferases; D010770:Phosphotransferases