Mediation of hyperthermia by prostaglandin E2: a new hypothesis.
In rat hypothalamus prostaglandin (PG) E2, unlike PGF2 or arachidonic acid shared the site of hyperthermic action with E. coli endotoxin. The in vitro catabolism of PGE2 in the hypothalami of endotoxin-treated rats was significantly suppressed. It is proposed that endotoxin fever in rats is due to the inhibition of PGE2 breakdown in the hypothalamus.
D000818:Animals; D004731:Endotoxins; D005334:Fever / Q000378:metabolism*; D007031:Hypothalamus / Q000378:metabolism; D011458:Prostaglandins E / Q000378:metabolism*; D051381:Rats
D004731:Endotoxins; D011458:Prostaglandins E