Digoxin elimination by exchange transfusion.
The report covers four cases presenting simultaneous indications for digitalisation and exchange transfusions. Intravenous administration of digoxin was followed: 1. by monitoring of the behaviour of the plasma digoxin level; 2. by determination of the total amount of glycoside eliminated by the blood exchange. Particular attention was paid to the effect of the delay between injection and exchange transfusion on the amount of digoxin eliminated. All four cases showed moderate falls in plasma levels. The amounts of digoxin eliminated by exchange transfusion were in reverse relationship to the delay between administration of digoxin and the blood exchange. At no time did the eliminated fraction exceed 5% of the total amount present in the body.
D002675:Child, Preschool; D004077:Digoxin / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D005078:Exchange Transfusion, Whole Blood; D005260:Female; D006801:Humans; D006932:Hyperbilirubinemia / Q000628:therapy; D007231:Infant, Newborn; D008297:Male; D009145:Mushroom Poisoning / Q000628:therapy; D013997:Time Factors
D004077:Digoxin