Properties of heparin--poly(methyl methacrylate) copolymers. II.
A heparin--poly(methyl methacrylate) copolymer in which heparin has been covalently bound was studied. This copolymer showed no release of heparin but presented heparin-like anticoagulant activity when suspended in plasma. After contact with plasma, the copolymer lost part of its antithrombin activity which could be restored by a high ionic-strength medium. Because of its solid form, this copolymer offers new possibilities for producing interesting anticoagulant surfaces.
D000925:Anticoagulants; D055598:Chemical Phenomena; D002621:Chemistry; D002951:Citrates; D004347:Drug Interactions; D006493:Heparin / Q000032:analysis / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008768:Methylmethacrylates / Q000494:pharmacology*; D011109:Polymethacrylic Acids / Q000494:pharmacology; D011479:Protamines / Q000494:pharmacology; D012965:Sodium Chloride; D013917:Thrombin / Q000502:physiology; D013997:Time Factors
D000925:Anticoagulants; D002951:Citrates; D008768:Methylmethacrylates; D011109:Polymethacrylic Acids; D011479:Protamines; D012965:Sodium Chloride; D006493:Heparin; D013917:Thrombin