Detection of HBsAg in coagulation Factor IX concentrates.
HBsAg was detected in two commercial clotting factor concentrates: Proplex (Hyland) and Konyne (Cutter). HBsAg was positive by RIA in samples of Proplex but not Konyne. Immune-electron microscopy, however, demonstrated clumped small spheres of HBsAg in both preparations, and lamellar-type strands were seen in several preparations.
D001803:Blood Transfusion; D005164:Factor IX; D006511:Hepatitis B Antigens / Q000032:analysis; D006801:Humans; D008854:Microscopy, Electron; D011863:Radioimmunoassay
D006511:Hepatitis B Antigens; D005164:Factor IX