Increase of free arachidonic acid by furosemide in man as the cause of prostaglandin and renin release.
Arachidonic acid (C20 :4) plasma renin activity (PRA), PGF2alpha, and sodium excretion were determined before and after furosemide in men. C20 : 4 and PRA increase (p less than 0.005) within 10 min after furosemide, PRA then decreased again whereas C20 : 4 levels remained elevated. Maximal exretion of PGF2alpha and sodium occurred 30-60 min after furosemide. Indomethacin prevented the rise of C20 : 4, PRA and PGF2alpha after furosemide, leaving sodium excretion unaltered. The release of C20 : 4 is assumed to be the primary mechanism of furosemide to increase PG biosynthesis and renin release.
D000328:Adult; D000804:Angiotensin II / Q000097:blood; D001095:Arachidonic Acids / Q000097:blood*; D005665:Furosemide / Q000494:pharmacology*; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D011460:Prostaglandins F / Q000652:urine*; D012083:Renin / Q000097:blood*; D012964:Sodium / Q000652:urine; D013997:Time Factors
D001095:Arachidonic Acids; D011460:Prostaglandins F; D000804:Angiotensin II; D005665:Furosemide; D012964:Sodium; D012083:Renin; D007213:Indomethacin