Estrogen treatment in tall girls.
36 tall girls aged 10.3 to 15.5 years were treated with ethinylestradiol (0.5 mg/day) and norethisterone (15 mg/day). To date treatment for seventeen girls has been completed. Before treatment their bone age ranged from 11.0 to 13.5 years and mean height prediction was 185.19 cm (181.40-193.00 cm). After about two years of treatment their final height averaged 178.96 cm (171.60-183.50 cm). Predicted height was reduced by an average of 6.23 cm. The reduction in final height was significantly greater when therapy was started before a bone age of 12 years. Thirteen girls, re-examined after discontinuation of therapy, all had regular menstrual bleeding within six months. There were no serious or irreversible side effects during the period of observation.
D000293:Adolescent; D001827:Body Height / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D001846:Bone Development / Q000187:drug effects; D002648:Child; D004341:Drug Evaluation; D004997:Ethinyl Estradiol / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006130:Growth Disorders / Q000517:prevention & control; D006801:Humans; D008572:Menarche; D009325:Nausea / Q000139:chemically induced; D009640:Norethindrone / Q000009:adverse effects / Q000627:therapeutic use*; D014839:Vomiting / Q000139:chemically induced
D004997:Ethinyl Estradiol; D009640:Norethindrone