[Effect of afferent abdominal vagus nerve stimulation on the blood circulation and respiration in the guinea pig].
In 38 urethan anesthetized guinea-pigs low frequency (1--30 Hz) electrical afferent stimulation of the abdominal vagus elicited cardiovascular and respiratory reflexes, which were eliminated by bilateral cervical vagotomy: 1. 2/3 of the animals showed a bradycardia with arrhythmia. 1/3 had no heart rate alteration. 2. Biphasic blood pressure alteration with an initial decrease and a following increase was the most common blood pressure response. Longlasting (10 sec) stimulation resulted in a blood pressure increase of 25 to 30 mmHg in 75% of the animals. 3. Acceleration of respiratory rate. A vago-vagal and/or vagosympathetic reflex is considered. It is assumed that the blood pressure curve is composed of adding both the depressor and pressor component. Two functional fibre groups in the afferent abdominal vagus are considered to be the anatomic substratum. Atropine had no effect on the alteration of respiratory rate and blood pressure; only the bradycardia could be eliminated.
D000818:Animals; D001775:Blood Circulation; D001794:Blood Pressure; D004558:Electric Stimulation; D006168:Guinea Pigs; D006339:Heart Rate; D008297:Male; D012018:Reflex; D012119:Respiration; D014630:Vagus Nerve / Q000502:physiology*
Uber die Wirkung von afferenter, abdominaler Vagusreizung auf Kreislauf und Atmung des Meerschweinchens