The influence of prednisolone on hepatic function in normal subjects. Effects on galactose elimination capacity, sulfobromophthalein transport maximum and storage capacity, and D-glucaric acid output.
In view of the importance of liver tests in the follow-up of patients under treatment with corticosteroid hormones, 20 mg of prednisolone were given by mouth to normal volunteers for 4 days and hepatic function was assessed before and during treatment. Despite significant falls in plasma cortisol and serum bilirubin concentrations, the galactose elimination capacity, the BSP tests, and the urinary D-glucaric acid output remained essentially unchanged. Consequently no pharmacological effect of this corticosteroid hormone on the examined tests could be detected.
D000284:Administration, Oral; D000328:Adult; D005260:Female; D005690:Galactose / Q000378:metabolism*; D005977:Glutarates / Q000378:metabolism; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008099:Liver / Q000187:drug effects* / Q000502:physiology; D008111:Liver Function Tests; D008297:Male; D011239:Prednisolone / Q000494:pharmacology*; D011241:Prednisone / Q000008:administration & dosage; D013448:Sulfobromophthalein / Q000378:metabolism
D005977:Glutarates; D013448:Sulfobromophthalein; D011239:Prednisolone; D011241:Prednisone; D006854:Hydrocortisone; D005690:Galactose