Effects of purines and pyrimidines on the fungistatic activity of 5-fluorocytosine in Aspergillus species.
The ability of some exogenously supplied purines, pyrimidines, and their nucleosides to antagonize the in vitro fungistatic activity of 5-fluorocytosine (5-FC) in Aspergillus species was examined. All compounds tested except thymidine were capable of altering the minimal inhibitory concentration of 5-FC for seven strains of aspergilli tested. In most instances, there was a reciprocal correlation between the ability of a compound to antagonize the fungistatic activity of 5-FC and the quantity of 5-FC taken up by cells in the presence of the compound over a 72-h period.
D000935:Antifungal Agents; D001230:Aspergillus / Q000187:drug effects* / Q000378:metabolism; D003596:Cytosine / Q000031:analogs & derivatives*; D005437:Flucytosine / Q000378:metabolism / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009705:Nucleosides / Q000494:pharmacology; D011687:Purines / Q000494:pharmacology*; D011743:Pyrimidines / Q000494:pharmacology*
D000935:Antifungal Agents; D009705:Nucleosides; D011687:Purines; D011743:Pyrimidines; D003596:Cytosine; D005437:Flucytosine