title: Lecithin: cholesterol acyl transferase activity in the serum of rats fed saturated and unsaturated fats.
abstract: Groups of rats were fed diets containing either butter, beef, fat or safflower oil. After 20 or 70 days of feeding, blood was taken from the animals in a postabsorptive state. Serum lipid levels and lecithin: cholesterol acyl transferase activity were measured. Feeding the different fats did not alter serum total cholesterol levels but free cholesterol and triglycerides were significantly lower in the safflower oil-fed group. Net cholesterol esterification in vitro was also significantly depressed in the safflower oil-fed group and this was shown to be due to the inability of the lipoprotein substrate to support the reaction rather than because of low LCAT enzyme activity.
mesh_terms: D000217:Acyltransferases / Q000097:blood*; D000818:Animals; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D004041:Dietary Fats / Q000008:administration & dosage*; D008055:Lipids / Q000097:blood*; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000097:blood*; D051381:Rats; D012450:Safflower Oil / Q000008:administration & dosage
chemical_list: D004041:Dietary Fats; D008055:Lipids; D012450:Safflower Oil; D002784:Cholesterol; D000217:Acyltransferases; D007862:Phosphatidylcholine-Sterol O-Acyltransferase