Absence of sodium appetite in cyclophosphamide and DOCA treated house mice.
Intraperitoneal administration of cyclophosphamide 100 mg/kg and 200 mg/kg significantly lowered plasma sodium and significantly increased plasma potassium but did not result in saline preference in a strain of wild-derived house mice given a choice between water and saline (0.15M) to drink. Deoxycorticosterone acetate treatment in dosages up to 1.5 mg for four days also failed to increase salt intake, The data suggest a possible absence of a sodium appetite mechanism in this species.
D000818:Animals; D001066:Appetite / Q000187:drug effects*; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000494:pharmacology*; D003900:Desoxycorticosterone / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004327:Drinking Behavior / Q000187:drug effects; D004338:Drug Combinations; D008297:Male; D051379:Mice; D012964:Sodium / Q000378:metabolism
D004338:Drug Combinations; D003900:Desoxycorticosterone; D003520:Cyclophosphamide; D012964:Sodium