Effect of lysine-acetylsalicylate on serum gastrin levels.
The effect on serum gastrin levels of lysin-acetylsalicylate (LAS), water soluble derivative of acetylsalicylic acid, was investigated in mice. Intragastrically administered LAS did not at all alter serum gastrin values while--when given via the intravenous route--LAS not earlier than at the very high dose of 450 mug/g caused a short-lived significant increase in serum gastrin. These results are in keeping with the view that salicylates do not owe their potential ulcerogenic properties to stimulation the gastrin-gastric secrection mechanism.
D000818:Animals; D001241:Aspirin / Q000031:analogs & derivatives* / Q000494:pharmacology; D005755:Gastrins / Q000097:blood*; D008297:Male; D051379:Mice; D010437:Peptic Ulcer / Q000139:chemically induced
D005755:Gastrins; D001241:Aspirin