Lack of stimulation by high amphetamine doses following a low dose of spiperone.
The locomotor stimulant and stereotypic effects of amphetamine were investigated in rats pretreated with the specific dopaminergic blocker spiperone (0.25 mg/kg). Amphetamine doses from 8.0 to 64.0 mg/kg failed to stimulate behavior significantly and consistently after spiperone treatment. These results suggest the possibility of non-competitive antagonism by spiperone at dopaminergic synapses.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002090:Butyrophenones / Q000494:pharmacology*; D003913:Dextroamphetamine / Q000008:administration & dosage / Q000037:antagonists & inhibitors*; D008297:Male; D051381:Rats; D013134:Spiperone / Q000494:pharmacology*; D013268:Stimulation, Chemical
D002090:Butyrophenones; D013134:Spiperone; D003913:Dextroamphetamine