Serum and liver lipid responses to 3-hydroxy-3-methylglutaric acid in rats on different carbohydrate diets.
Groups of male adult albino rats were administered 3-hydroxy-3-methylglutaric acid (HMG) intraperitoneally along with six diets differing only in the type of carbohydrate used. Groups not treated with HMG served as controls. HMG showed a significant cholesterol- and tri-glyceride-lowering effect in the whole serum, serum beta-lipoproteins, and liver of animals on all types of dietary carbohydrates. The effect was more marked in glucose, fructose, sucrose, and lactose. The phospholipid levels in whole serum, serum beta-lipoproteins, as well as in liver were also significantly lowered on all types of carbohydrates except dextrin and starch fed animals, where it had no effect on liver levels. The lipid-lowering effect of HMG seems to be independent of the type of carbohydrate in diet.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D004040:Dietary Carbohydrates / Q000378:metabolism*; D005977:Glutarates / Q000494:pharmacology*; D006880:Hydroxy Acids / Q000494:pharmacology; D050356:Lipid Metabolism; D008074:Lipoproteins / Q000097:blood; D008099:Liver / Q000378:metabolism*; D008297:Male; D010743:Phospholipids / Q000097:blood / Q000378:metabolism; D051381:Rats; D014280:Triglycerides / Q000097:blood / Q000378:metabolism
D004040:Dietary Carbohydrates; D005977:Glutarates; D006880:Hydroxy Acids; D008074:Lipoproteins; D010743:Phospholipids; D014280:Triglycerides; D002784:Cholesterol