title: Annulate lamellae in spontaneous prolactin cell adenomas of the rat pituitary.
abstract: Electron microscopy of 13 pituitary prolactin cell adenomas, removed at autopsy from untreated female aging Long-Evans rats, revealed the presence of annulate lamellae in 3 tumors. No annulate lamellae were detected in 10 non-tumorous pituitary glands of adult untreated rats. Direct continuity was demonstrated between annulate lamellae and rough-surfaced endoplasmic reticulum, consistent with the assumption that annulate lamellae may originate from and/or transform to endoplasmic reticulum membranes. The results indicate that annulate lamellae are not uncommonly formed in prolactin cell adenomas, i.e. in cells which have a faster growth rate than non-tumorous adenohypophysiocytes.
mesh_terms: D000238:Adenoma, Chromophobe / Q000378:metabolism / Q000648:ultrastructure / Q000662:veterinary*; D000818:Animals; D002454:Cell Differentiation; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D005260:Female; D008854:Microscopy, Electron; D009940:Organoids / Q000648:ultrastructure*; D010911:Pituitary Neoplasms / Q000378:metabolism / Q000648:ultrastructure / Q000662:veterinary*; D011388:Prolactin / Q000378:metabolism*; D051381:Rats; D012376:Rodent Diseases / Q000473:pathology*
chemical_list: D011388:Prolactin