title: Pentazocine ulcers.
abstract: Four cases of skin ulceration in pentazocine addicts are presented. Appearing in broad areas of a peculiar wood induration and often massive in size, these ulcers can be clinically distinguished from comparable skin manifestations in other types of drug abuse. The histological finding of an obliterative vasculitis of the small vessels helps to explain the non-healing nature of these lesions. It also offers a rationale for the surgical therapy of wide excision, prior to skin grafting.
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007279:Injections, Subcutaneous / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D010423:Pentazocine / Q000009:adverse effects*; D012883:Skin Ulcer / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D013848:Thigh
chemical_list: D010423:Pentazocine