Intensification of amphetamine-induced excitation by methysergide, a serotonergic receptor blocker.
Methysergide, a serotonergic receptor blocker, was studied to determine its effects against d-amphetamine-induced excitation as measured by convulsions elicited by handling in mice. Significant intensification (p less than 0.01) of the action of d-amphetamine was observed in mice. These results indicate that reduction in serotonergic activity in the central nervous system enhances excitation induced by d-amphetamine.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003913:Dextroamphetamine / Q000494:pharmacology*; D008297:Male; D008784:Methysergide / Q000494:pharmacology*; D051379:Mice; D011985:Receptors, Serotonin / Q000187:drug effects*; D012640:Seizures / Q000139:chemically induced; D013997:Time Factors
D011985:Receptors, Serotonin; D003913:Dextroamphetamine; D008784:Methysergide