Peripheral and optic neuritis in a patient with hemoglobin SC disease during treatment of salmonella osteomyelitis with chloramphenicol.
Peripheral and optic neuritis developed in a girl with hemoglobin SC disease, during long-term high-dose treatment of Salmonella osteomyelitis with chloramphenicol. Although the neurotoxicity of this antibiotic is well documented, the child's pain was initially considered to be a form of sickle-cell dactylitis.
D002648:Child; D002701:Chloramphenicol / Q000009:adverse effects*; D005260:Female; D006451:Hemoglobin, Sickle; D006453:Hemoglobinopathies / Q000150:complications*; D006801:Humans; D009443:Neuritis / Q000139:chemically induced; D009902:Optic Neuritis / Q000139:chemically induced*; D010019:Osteomyelitis / Q000188:drug therapy* / Q000209:etiology / Q000382:microbiology; D012475:Salmonella / Q000302:isolation & purification
D006451:Hemoglobin, Sickle; D002701:Chloramphenicol