Serum and liver radioactivity levels in mice after intraperitoneal and subcutaneous injection of [14C]orotic acid.
[14C]Orotic acid was rapidly distributed in blood after both i.p. and s.c. injection but was not completely absorbed from the peritoneal cavity until 20 min after injection. S.c. injection should be an acceptable alternative to i.p. injection although the incorporation into the liver acid soluble- and RNA-fractions was somewhat delayed after the s.c. injection.
D000818:Animals; D007274:Injections, Intraperitoneal; D007279:Injections, Subcutaneous; D007700:Kinetics; D008099:Liver / Q000378:metabolism*; D008297:Male; D051379:Mice; D009963:Orotic Acid / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D012313:RNA / Q000096:biosynthesis
D009963:Orotic Acid; D012313:RNA