Partial denervation affects both denervated and innervated fibers in the mammalian skeletal muscle.
Partial denervation of the rat extensor digitorum longus muscle was performed by sectioning only one of the sciatic nerve roots. Measurements of spike resistance to tetrodotoxin in individual muscle fibers revealed denervation changes not only in the denervated fibers but also in the adjacent innervated ones. The results support the concept that products of nerve degeneration play a role in the origin of muscle changes induced by denervation.
D000200:Action Potentials / Q000187:drug effects*; D000818:Animals; D004351:Drug Resistance; D008564:Membrane Potentials; D009045:Motor Endplate / Q000502:physiology; D009121:Muscle Denervation; D009132:Muscles / Q000294:innervation* / Q000502:physiology; D009410:Nerve Degeneration; D009469:Neuromuscular Junction / Q000502:physiology; D051381:Rats; D013779:Tetrodotoxin / Q000494:pharmacology
D013779:Tetrodotoxin