Effect of furosemide on plasma fibrinolytic activity and urokinase excretion.
Plasma fibrinolytic activity, as measured by the fibrin-plate method, is enhanced after a single intravenous administration of 40 mg of furosemide. This effect becomes evident within 30 min and a peak response is attained 6 h after i.v. administration. On successive administration of furosemide, the fibrinolytic effect persists and the second peak becomes manifest again after 6 h. Following the parenteral administration of furosemide there is an initial decrease of urinary urokinase excretion which returns to a normal level after 3 to 6 h. Possible mechanisms which may explain the enhanced fibrinolytic activity after furosemide administration are discussed.
D010450:Endopeptidases / Q000652:urine*; D005342:Fibrinolysis / Q000187:drug effects*; D005665:Furosemide / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007275:Injections, Intravenous; D012712:Serum Globulins / Q000378:metabolism*; D013997:Time Factors; D014568:Urokinase-Type Plasminogen Activator / Q000652:urine*
D012712:Serum Globulins; D005665:Furosemide; D010450:Endopeptidases; D014568:Urokinase-Type Plasminogen Activator