Chemotherapy of an experimental Bacteroides fragilis infection in mice.
The efficacies of five common antimicrobial agents were determined for a pure Bacteroides fragilis infection in mice. Therapy was begun 4 h after bacterial injection and given every 8 h thereafter for 5 days. Blood levels were determined over an 8-h period for each concentration of antibiotic tested. Clindamycin and tetracycline were the most effective in preventing the formation of abscesses. Chloramphenicol, penicillin G, and cephalothin were not effective in protecting the mice from infection.
D000038:Abscess / Q000188:drug therapy; D000818:Animals; D001442:Bacteroides Infections / Q000097:blood / Q000188:drug therapy*; D001441:Bacteroides fragilis; D002512:Cephalothin / Q000097:blood / Q000627:therapeutic use; D002701:Chloramphenicol / Q000097:blood / Q000627:therapeutic use; D002981:Clindamycin / Q000097:blood / Q000627:therapeutic use; D004195:Disease Models, Animal; D051379:Mice; D008813:Mice, Inbred ICR; D008826:Microbial Sensitivity Tests; D010400:Penicillin G / Q000097:blood / Q000627:therapeutic use; D013752:Tetracycline / Q000097:blood / Q000627:therapeutic use
D002981:Clindamycin; D002701:Chloramphenicol; D013752:Tetracycline; D010400:Penicillin G; D002512:Cephalothin