title: Evaluation of the immunocompetance of patients with transitional cell carcinoma of the bladder.
abstract: The cellular immunocompetence was examined by means of the quantitative DNCB hypersensitivity reaction in 152 patients with transitional cell carcinomas of the bladder of Broders grades 1-4. Against a control group of 367 normal controls of both sexes, 85 patients with transitional cell carcinomas of grades 1 and 2 showed a normal DNCB reactivity, irrespective of the frequency of tumour recurrence. In 9 patients of this group, an increase of malignancy from grade 2 to grade 3 was observed; the simultaneous deterioration of immunocompetence, however, was not statistically significant. On the other hand, with transitional cell carcinomas of grades 3 and 4, significant impairment of immunocompetence correlating with the tumour stage was noted.
mesh_terms: D000328:Adult; D000368:Aged; D000917:Antibody Formation; D002295:Carcinoma, Transitional Cell / Q000276:immunology*; D004137:Dinitrochlorobenzene; D004342:Drug Hypersensitivity; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D001749:Urinary Bladder Neoplasms / Q000276:immunology*
chemical_list: D004137:Dinitrochlorobenzene