The effect of a low-protein diet on some pharmacokinetic parameters of hexobarbital in the rat.
Hexobarbital, given at a dose of 100 mg/kg iv crosses the tissue barriers more rapidly, and is more quickly eliminated from the body of rats kept for a long period of time on a low-protein diet, D-III, than from the control rats.
D000818:Animals; D001835:Body Weight; D004044:Dietary Proteins; D005260:Female; D006591:Hexobarbital / Q000097:blood / Q000378:metabolism* / Q000652:urine; D007700:Kinetics; D008862:Microsomes, Liver / Q000378:metabolism; D009929:Organ Size; D051381:Rats; D013997:Time Factors
D004044:Dietary Proteins; D006591:Hexobarbital