Pheniramine aminosalicylate overdosage. Reversal of delirium and choreiform movements with tacrine treatment.
We describe a case of central anticholinergic syndrome with choreiform movements after an overdose of pheniramine aminosalicylate. The symptoms and signs of the condition were reversed by the intravenous administration of the cholinesterase-inhibitor tetrahydroaminacrine. We also discuss the concept of adrenergic-cholinergic imbalance in relation to this case and recommend the use of centrally acting anticholinesterase agents in the treatment of specific cases of drug overdose.
D000166:Acridines / Q000627:therapeutic use*; D000293:Adolescent; D002819:Chorea / Q000139:chemically induced / Q000188:drug therapy; D003693:Delirium / Q000139:chemically induced / Q000188:drug therapy; D005260:Female; D006801:Humans; D010632:Pheniramine / Q000031:analogs & derivatives* / Q000506:poisoning; D019966:Substance-Related Disorders; D013619:Tacrine / Q000627:therapeutic use*
D000166:Acridines; C014743:pheniramine aminosalicylate; D010632:Pheniramine; D013619:Tacrine