Experimental model for systematic study of impaired microvascular reperfusion.
A technique is described for reliably producing quantifiable impairment of microvascular reperfusion of the brain after ischemia in dogs. The technique is derived from an analysis of the cerebrospinal fluid compression ischemia model as a Starling resistor. It is proposed that this model would be useful in systematic study of post-ischemic impairment of reperfusion.
D000818:Animals; D001794:Blood Pressure; D002555:Cerebrospinal Fluid; D002560:Cerebrovascular Circulation; D004195:Disease Models, Animal; D004285:Dogs; D002546:Ischemic Attack, Transient / Q000209:etiology; D008297:Male; D008833:Microcirculation; D011312:Pressure