Major innervation of newborn rat cortex by monoaminergic neurons.
A major monoaminergic innervation in infant rat neocortex, predominantly in layer IV, has been demonstrated by ultrastructural and biochemical studies after the administration of exogenous catecholamine precursors and congeners. One-third of all cortical synapses have an uptake-storage mechanism for catecholamines. In newborn cortex, the storage capacity for catecholamines is tenfold greater than the endogenous levels, and the uptake-storage mechanism matures earlier than the ability to synthesize neurotransmitter.
D000320:Adrenergic Fibers; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D002395:Catecholamines / Q000096:biosynthesis / Q000378:metabolism*; D002540:Cerebral Cortex / Q000166:cytology* / Q000378:metabolism / Q000648:ultrastructure; D006892:Hydroxydopamines / Q000378:metabolism; D007980:Levodopa / Q000378:metabolism; D051381:Rats; D012110:Reserpine / Q000494:pharmacology; D013569:Synapses / Q000378:metabolism / Q000648:ultrastructure; D013572:Synaptic Vesicles / Q000378:metabolism
D002395:Catecholamines; D006892:Hydroxydopamines; D007980:Levodopa; D012110:Reserpine