The binding of a synthetic progestin, R5020 to transcortin and serum albumin.
R5020 (17,21-dimethyl-19-nor-4,9-pregnadiene-3,20-dione), a synthetic progestin, was tested for its binding to purified human transcortin, albumin and human serum. Scatchard analysis showed that R5020 bound relatively weakly to transcortin (Kass = 8 X 10(6)M-1); in 20% human serum or albumin greater than 90% was bound with low Kass and an indeterminate number of binding sites.
D006801:Humans; D007700:Kinetics; D009649:Norpregnadienes / Q000097:blood*; D045167:Progesterone Congeners / Q000097:blood*; D011485:Protein Binding; D012709:Serum Albumin / Q000378:metabolism*; D014156:Transcortin / Q000378:metabolism*
D009649:Norpregnadienes; D045167:Progesterone Congeners; D012709:Serum Albumin; D014156:Transcortin