title: [Acute poisoning with tricylic antidepressants and treatment with physostigmine salicylate (author's transl)].
abstract: Three cases of self poisoning with tricyclic antidepressants (TAD) are reported, one of them with a potentially lethal dose. All three cases were treated with physostigmine salicylate (PS)  and in two cases there was complete reversal of coma within a few minutes. In striking contrast to the reported high incidence of cardiac arrhythmias no cardiac complications were observed in any of the cases. Therefore we think that the use of PS should be considered when treating cases of TAD poisoning.
mesh_terms: D000208:Acute Disease; D000929:Antidepressive Agents, Tricyclic / Q000506:poisoning*; D000931:Antidotes / Q000627:therapeutic use; D005260:Female; D006801:Humans; D010830:Physostigmine / Q000627:therapeutic use*; D011041:Poisoning / Q000188:drug therapy; D012459:Salicylates / Q000627:therapeutic use*; D013406:Suicide, Attempted
chemical_list: D000929:Antidepressive Agents, Tricyclic; D000931:Antidotes; D012459:Salicylates; D010830:Physostigmine
vernacular_title: Die akute Vergiftung durch trizyklische Antidepressiva und ihre Therapie mit Physostigminsalizylat