Inhibition of 1,2-dimethylhydrazine metabolism by disulfiram.
1. The effects of disulfiram on the metabolism of 1,2-dimethylhydrazine were studied in CDF rats. 2. Treatment with disulfiram causes enhanced elimination of azomethane in the expired air, inhibition of CO2 production, and decreased levels of 1,2-dimethylhydrazine metabolites in the urine. 3. These results suggest that disulfiram inhibits the N-oxidation of azomethane to azoxymethane, thus preventing further metabolism to the ultimate carcinogenic species, and provide an explanation for the observations that disulfiram inhibits 1,2-dimethylhydrazine-induced neoplasia of the large intestine.
D000818:Animals; D001391:Azo Compounds / Q000378:metabolism; D002245:Carbon Dioxide / Q000378:metabolism; D004221:Disulfiram / Q000494:pharmacology*; D006834:Hydrazines / Q000378:metabolism*; D008297:Male; D009002:Monomethylhydrazine / Q000031:analogs & derivatives / Q000378:metabolism* / Q000652:urine; D051381:Rats
D001391:Azo Compounds; D006834:Hydrazines; D002245:Carbon Dioxide; D004221:Disulfiram; D009002:Monomethylhydrazine