Brain-type creatine kinase isoenzyme. Occurrence in serum in acute cerebral disorders.
Acute brain damage-cerebrovascular or cardiovascular, traumatic or infectious-released brain-type isoenzyme of creatine kinase (BB-CK) into the circulation within a few hours in 16 of 62 patients (26%). Occurrence of BB-CK was transient in the serum. BB-CK activity was found in the peripheral blood in 13 of 23 patients with diffuse brain damage compared to three of 39 patients with a local cerebrovascular accident (P less than .0005). The mortality of patients having BB-CK in their serum was 63% compared to 39% of those without BB-CK activity in their serum (P less than .05).
D000328:Adult; D001921:Brain / Q000201:enzymology; D001930:Brain Injuries / Q000201:enzymology*; D002543:Cerebral Hemorrhage / Q000201:enzymology*; D003288:Contusions; D003402:Creatine Kinase / Q000097:blood*; D005260:Female; D006323:Heart Arrest / Q000150:complications; D006801:Humans; D002542:Intracranial Embolism and Thrombosis / Q000201:enzymology; D007527:Isoenzymes / Q000097:blood; D008297:Male; D008581:Meningitis / Q000201:enzymology; D008875:Middle Aged; D013345:Subarachnoid Hemorrhage / Q000201:enzymology
D007527:Isoenzymes; D003402:Creatine Kinase