Induction in rats of paranasal sinus carcinomas with radioactive cerium chloride.
A colloidal suspension of radioactive cerium stabilized in the form of hydroxide was inoculated into young Sprague-Dawley rats near the maxillary sinus. Well-differentiated epidermoid carcinomas of the paranasal sinus were obtained in 8 of 12 rats and in 8 of 9 animals that liver more then 200 days. Therefore, this istope was highly effectivein inducing tumors at the site of injection. The uniformity of the histologic type of tumors induced under these experimental conditions was remarkable.
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000209:etiology* / Q000473:pathology; D002565:Cerium Radioisotopes / Q000008:administration & dosage; D003102:Colloids; D008297:Male; D009374:Neoplasms, Experimental / Q000209:etiology / Q000473:pathology; D009381:Neoplasms, Radiation-Induced / Q000473:pathology*; D010255:Paranasal Sinus Neoplasms / Q000209:etiology* / Q000473:pathology; D051381:Rats
D002565:Cerium Radioisotopes; D003102:Colloids