Effect of estradiol on prostaglandin metabolism in rat uterus.
The purpose of this work was to investigate the effect of a single injection of estradiol (10 microng/rat) on prostaglandin(PG) metabolism in rat uterus. The PG content of uterus was increased within 6 hr after estradiol injection but the incorporation of 3H-arachidonic acid into PG in uterus was not changed within same period. The uptake of 3H-PG was increased within 6 hr after estradiol injection. In these results, it is discussed that PG from other tissue are also involved in the metabolism of PG in uterus.
D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism; D002850:Chromatography, Gel; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D011458:Prostaglandins E / Q000378:metabolism*; D011460:Prostaglandins F / Q000378:metabolism*; D051381:Rats; D014599:Uterus / Q000378:metabolism*
D001095:Arachidonic Acids; D011458:Prostaglandins E; D011460:Prostaglandins F; D004958:Estradiol