Prevention of renal failure in rats receiving cis-diamminedichloroplatinum(II) by administration of furosemide.
The clinicopathological signs of renal failure induced in rats by weekly i.v. administration of cis-diamminedichloroplatinum(II) were prevented by pretreatment with furosemide. Weight loss, anemia, and generalized toxic effects of the drug were not effected by furosemide.
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology / Q000517:prevention & control; D000818:Animals; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects*; D005665:Furosemide / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344
D005665:Furosemide; D002945:Cisplatin