Effect of metoclopramide on the lower oesophageal sphincter. An experimental study in dogs.
Oesophageal, lower oesophageal sphincter and gastric fundal pressures were measured with a triple lumen, open tip-infused catheter in dogs before and after intravenous injection of metoclopramide. The mean basal value of the lower oesophageal sphincter pressure was 5.3+/-2.7 mmHg. Metoclopramide injection caused a significant increase in this pressure. The effect of metoclopramide started immediately and disappeared about one hour after intravenous injection.
D000818:Animals; D004285:Dogs; D004943:Esophagogastric Junction / Q000187:drug effects*; D007275:Injections, Intravenous; D008787:Metoclopramide / Q000008:administration & dosage / Q000494:pharmacology*; D011312:Pressure; D013270:Stomach / Q000187:drug effects
D008787:Metoclopramide