Conditioned narcotic withdrawal in humans.
Subjective and physiological manifestations of the narcotic withdrawal syndrome were produced as a conditioned response. Withdrawal reactions precipitated by the narcotic antagonist naloxone in methadone-dependent volunteers were the unconditioned response. These data support clinical anecdotes of withdrawal symptoms occurring in former addicts when they return to their drug-related environment.
D000328:Adult; D003214:Conditioning, Classical / Q000502:physiology*; D006801:Humans; D008297:Male; D008691:Methadone / Q000627:therapeutic use; D009270:Naloxone; D013375:Substance Withdrawal Syndrome / Q000139:chemically induced / Q000188:drug therapy / Q000503:physiopathology*
D009270:Naloxone; D008691:Methadone