Drug interactions on body temperature maintenance in the mouse.
Exposure of mice to an environmental temperature leads to a loss of body temperature and death in 5-6 hours. Intraperitoneal injection of water or d-amphetamine exacerbates this effect, while caffeine has a modest antagonistic effect. The combination of caffeine and d-amphetamine is synergistic and leads to a rapid loss in body temperature with death occurring in less than 3 hours.
D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D002110:Caffeine / Q000008:administration & dosage / Q000494:pharmacology*; D003080:Cold Temperature; D003913:Dextroamphetamine / Q000008:administration & dosage / Q000494:pharmacology*; D004347:Drug Interactions; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D013997:Time Factors
D002110:Caffeine; D003913:Dextroamphetamine