Inhibition of human platelet mitochondrial protein synthesis by chloramphenicol.
Human platelet mitochondrial protein synthesis, assayed by "in vitro" 3H-leucine incorporation into the protein moiety of isolated mitochondria, was shown to be inhibited by a therapeutic concentration of chloramphenicol (CAP). This finding is in accordance with the ultrastructural damage caused to these organelles by the antibiotic, and with the inhibition of mitochondrial protein synthesis found in other kinds of mammalian cells.
D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D001798:Blood Proteins / Q000096:biosynthesis*; D002701:Chloramphenicol / Q000494:pharmacology*; D003864:Depression, Chemical; D006801:Humans; D066298:In Vitro Techniques; D007930:Leucine / Q000378:metabolism; D008854:Microscopy, Electron; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism
D001798:Blood Proteins; D002701:Chloramphenicol; D007930:Leucine