Tonography in the normal and glaucomatous beagle.
A standard procedure for tonography was developed in the dog. Acepromazine, ketamine, xylazine, droperidol-fentamyl, and combinations of these drugs were evaluated for effects on blood pressure, intraocular pressure, and restraint of the dog for 4 minutes of Schiotz tonography of each eye. In dogs given a cepromazine (0.5 mg/kg intravenously) and then ketamine (10.0 mg/kg intramuscularly), the mean coefficient of aqueous humor out-flow in 24 normal Beagles was 0.24 mul/mm of Hg/minute (SD +/- 0.07). Mean coefficient of aqueous humor outflow in 35 glaucomatous Beagles, between 4 months to more than 37 months old, was 0.09 mul/mm of Hg/minute (SD +/- 0.04). Coefficient of aqueous humor out-flow was less in the older glaucomatous Beagle.
D000075:Acepromazine / Q000494:pharmacology; D000818:Animals; D001082:Aqueous Humor / Q000502:physiology; D001285:Atropine / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D004283:Dog Diseases / Q000503:physiopathology*; D004285:Dogs; D004329:Droperidol / Q000494:pharmacology; D004338:Drug Combinations; D005283:Fentanyl / Q000494:pharmacology; D005901:Glaucoma / Q000503:physiopathology / Q000662:veterinary*; D007103:Immobilization; D007429:Intraocular Pressure / Q000187:drug effects; D007649:Ketamine / Q000494:pharmacology; D011343:Procaine / Q000031:analogs & derivatives / Q000494:pharmacology; D014991:Xylazine / Q000494:pharmacology
D004338:Drug Combinations; D014991:Xylazine; D011343:Procaine; D000075:Acepromazine; D007649:Ketamine; D001285:Atropine; D004329:Droperidol; D005283:Fentanyl