title: Ultrastructure of spontaneously differentiated human malignant melanocytes cultured from primary tumors.
abstract: Ultrastructural study of early subcultures and established lines of human malignant melanocytes derived from primary tumors showed that melanocytes passed through a phase of dedifferentiation during which they took on a fibroblast-like appearance; then they had a phase of spontaneous redifferentiation. The fibroblast-like cells were characterized by the presence of network-like organelles in their cytoplasm, and the melanocytes by melanosomes.
mesh_terms: D002454:Cell Differentiation; D002460:Cell Line; D003593:Cytoplasm / Q000648:ultrastructure; D006801:Humans; D008543:Melanins / Q000378:metabolism; D008544:Melanocytes / Q000378:metabolism / Q000648:ultrastructure*; D008545:Melanoma / Q000378:metabolism / Q000648:ultrastructure*; D012878:Skin Neoplasms / Q000378:metabolism / Q000648:ultrastructure*
chemical_list: D008543:Melanins