Pathophysiological changes in serum erythropoiesis stimulating activity.
The mouse fetal liver cell bioassay has been used to study serum levels of erythropoiesis stimulating activity (ESA) in patients with a variety of haematological disturbances. The results indicate that this assay system provides a quantitative measurement of ESA, the concentration of which varies predictably in a manner which is consistent with it having a function as an in vivo regulator of erythropoiesis. Dose-response curves for serum ESA show highly significant parallelism with those obtained from sheep plasma erythropoietin and the International Reference Preparation of human urinary erythropoietin.
D000740:Anemia / Q000097:blood*; D000818:Animals; D001772:Blood Cell Count; D001782:Blood Donors; D004920:Erythropoiesis; D004921:Erythropoietin / Q000097:blood*; D006801:Humans; D051379:Mice; D011817:Rabbits; D013997:Time Factors
D004921:Erythropoietin