Adjuvant polyarthritis I: incorporation of quantitative measurements of humoral and cellular immune response.
A modified model of adjuvant arthritis is described that permits simultaneous quantitative measurement of the humoral and the cellular immune response to a secondary immunogen (el4 cells) in the arthritic rat. Application of the new model system to mechanism studies is illustrated with cyclophosphamide. The drug is shown to suppress adjuvant arthritis by a combined anti-inflammatory and immunosuppressive action.
D000818:Animals; D001168:Arthritis / Q000276:immunology*; D001169:Arthritis, Experimental / Q000188:drug therapy / Q000276:immunology*; D001379:Azathioprine / Q000494:pharmacology / Q000627:therapeutic use; D002460:Cell Line; D003520:Cyclophosphamide / Q000494:pharmacology / Q000627:therapeutic use; D004487:Edema / Q000188:drug therapy; D005620:Freund's Adjuvant; D007109:Immunity / Q000187:drug effects; D007111:Immunity, Cellular / Q000187:drug effects; D007166:Immunosuppressive Agents; D008297:Male; D009374:Neoplasms, Experimental / Q000276:immunology; D010653:Phenylbutazone / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000276:immunology; D013997:Time Factors
D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D005620:Freund's Adjuvant; D010653:Phenylbutazone; D001379:Azathioprine