title: Trimethoprim-sulphamethoxazole in the treatment of cholera. Comparison with tetracycline and chloramphenicol.
abstract: 67 of the bacteriologically proved adult acute cholera patients have been examined in order to evaluate the efficacy of TM-SMX in comparison with tetracycline and chloramphenicol in the eradication of Vibrio cholerae from stools. Our results demonstrated that all three drugs sterilized the stools of all patients within 3 days with the exception of one case of TM-SMX's group, which had negative culture stools after 4 days. On the basis of our experience it can be emphasized that TM-SMX can support chloramphenicol and tetracycline in the antibacterial treatment of cholera with the advantage that the drug is efficacious with daily administrations.
mesh_terms: D000328:Adult; D002701:Chloramphenicol / Q000627:therapeutic use*; D002771:Cholera / Q000188:drug therapy*; D004338:Drug Combinations; D004341:Drug Evaluation; D005243:Feces / Q000382:microbiology; D006801:Humans; D013420:Sulfamethoxazole / Q000627:therapeutic use*; D013752:Tetracycline / Q000627:therapeutic use*; D014295:Trimethoprim / Q000627:therapeutic use*; D014734:Vibrio cholerae / Q000302:isolation & purification
chemical_list: D004338:Drug Combinations; D002701:Chloramphenicol; D014295:Trimethoprim; D013752:Tetracycline; D013420:Sulfamethoxazole