title: Determination of oxamniquine in serum.
abstract: A method for the analysis of oxamniquine in serum (or plasma), sensitive to 10 ng/ml, was developed. Oxamniquine and a close structural analog as the internal standard were extracted from serum with ether. After derivatization with N,O-bis(trimethylsilyl)acetamide, oxamniquine was determined as its trimethylsilyl ether derivative by GLC using an electron-capture detector. The method was developed to study serum concentration profiles of different dosage forms of oxamniquine.
mesh_terms: D000818:Animals; D002849:Chromatography, Gas; D006801:Humans; D008722:Methods; D009600:Nitroquinolines / Q000097:blood*; D010073:Oxamniquine / Q000097:blood*; D013997:Time Factors
chemical_list: D009600:Nitroquinolines; D010073:Oxamniquine