title: The role of sialic acid in determining the survival of circulating interferon.
abstract: Rabbit interferon has been extensively desialytated and its metabolic behaviour has been evaluated in the rabbit. The half-life of asialointerferon is significantly shorter than the native interferon and its urinary excretion becomes negligible. Moreover the rapid uptake of asialointerferon by the isolated and perfused rabbit liver, suggests a hitherto unsuspected catobolic pathway for this glycoprotein.
mesh_terms: D000818:Animals; D007372:Interferons / Q000097:blood / Q000378:metabolism* / Q000652:urine; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D009439:Neuraminidase; D011817:Rabbits; D012794:Sialic Acids / Q000378:metabolism*
chemical_list: D012794:Sialic Acids; D007372:Interferons; D009439:Neuraminidase