Butyrophenones from the isomeric 2-amino-5-phenylbicyclo[3.3.1]nonanes.
The preparation of 5-phenylbicyclo [3.3.1]nonan-2-one is described starting from the ketal of 4-phenyl-4-(2-carbethoxyethyl)cyclohexan-1-one. The ketone was then taken on to the butyrophenone derivatives of endo-and exo-5phenylbicyclo[3.3.1]nonyl-2-amine. CNS screening results of these compounds are described.
D000818:Animals; D001643:Bridged Bicyclo Compounds; D002090:Butyrophenones / Q000138:chemical synthesis* / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D007536:Isomerism; D007928:Lethal Dose 50; D051379:Mice; D012640:Seizures / Q000139:chemically induced
D001643:Bridged Bicyclo Compounds; D002090:Butyrophenones