The action of serotonin on basal gastric secretion in the conscious rat after intraventricular and intraperitoneal administration.
In unanesthetized rats with chronic gastric fistulas the effect of various doses of 5-HT and atropine given intraperitoneally (i.p.) or into the lateral cerebral ventricle (i.c.) on basal gastric secretion was investigated. 5-HT given i.e. reduced HCl secretion more strongly than by the i.p. route. Atropine reduced gastric secretion equally after i.p. or i.e. administration. 5-HT given i.p. or i.c. produced a weaker inhibitory effect on basal gastric acid secretion than atropine. The stronger antisecretory action of 5-HT after i.c. than after i.p. administration indicates that the amine directly depresses the vegetative brain centers responsible for the basal secretory activity of the gastric mucosa.
D000818:Animals; D001285:Atropine / Q000008:administration & dosage / Q000494:pharmacology; D003864:Depression, Chemical; D005260:Female; D005750:Gastric Juice / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D012701:Serotonin / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
D012701:Serotonin; D001285:Atropine