The effect of tamoxifen on the in vitro production of prostaglandins F by the guinea pig uterine tissue.
Tamoxifen, a drug widely known as an antioestrogen is shown to depress the in vitro yield of PGF from pro-oestrus guinea pig uterine homogenates. The possibility that this is a novel antioestrogenic effect of tamoxifen is discussed.
D000818:Animals; D005260:Female; D006168:Guinea Pigs; D066298:In Vitro Techniques; D011460:Prostaglandins F / Q000096:biosynthesis*; D013267:Stilbenes / Q000494:pharmacology*; D013629:Tamoxifen / Q000494:pharmacology*; D014599:Uterus / Q000378:metabolism*
D011460:Prostaglandins F; D013267:Stilbenes; D013629:Tamoxifen