title: Temporal, morphological, and genetic responses of avian embryos to Azodrin, an organophosphate insecticide.
abstract: The effect of Azodrin on avian development was studied using a bobwhite quail line and two chicken lines--a single comb White Leghorn (SCWL) and an Australorp line. The bobwhite quail embryos did not respond to injections of Azodrin until stages 22 to 23 (6 days of incubation); the SCWL embryos, not until stage 18 (3 days of incubation) with increasing susceptibility through stage 20. The threshold concentration, at stage 19, for the SCWL was 0.4 mg/kg, for the Australorp, less. Within one hour of treatment stage-20 embryo shape was altered. There was, however, no immediate response from embryos treated earlier. The effect appeared as a reduced growth rate in the cervical flexure, and may be mediated by interference with the normal energy balance. The response, once initiated, was continuous through 10 days of incubation.
mesh_terms: D000014:Abnormalities, Drug-Induced; D000818:Animals; D002642:Chick Embryo; D004305:Dose-Response Relationship, Drug; D004531:Eggs / Q000032:analysis; D007306:Insecticides / Q000032:analysis; D008999:Monocrotophos / Q000032:analysis; D011784:Quail; D013045:Species Specificity; D013997:Time Factors
chemical_list: D007306:Insecticides; D008999:Monocrotophos