Changes in reaction time and drug plasma concentrations after nitrazepam and glutethimide.
1 The effects of nitrazepam, glutethimide and placebo were assessed in a double-blind cross-over study with five healthy human subjects, using reaction time, and relating changes to drug concentrations in the plasma. 2 After glutethimide in all five subjects, and after nitrazepam in four subjects, larger doses led to higher concentrations in plasma and to greater changes in reaction time; one subject displayed the higher nitrazepam concentrations and the greater effect following the smaller dose. 3 The relationship between change in reaction time and concentration appeared to be mainly a within-subject dose-effect relationship, with the peak concentration in plasma as the 'dose' and the area under the reaction time curve as the effect.
D000328:Adult; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D005984:Glutethimide / Q000097:blood / Q000494:pharmacology*; D006801:Humans; D008297:Male; D009567:Nitrazepam / Q000097:blood / Q000494:pharmacology*; D011930:Reaction Time / Q000187:drug effects*; D013997:Time Factors
D009567:Nitrazepam; D005984:Glutethimide