Complement fixing site of human IgG1.
A number of chemical modifications were made to purified human IgG1. The effects of these modifications on the complement activity of the immunoglobulin were studied using aggregation on latex and measuring the consumption of the complement by CH50-quantitation. Tryptophan and tyrosine are implicated in the complement fixing site of this human immunoglobulin, and an arginine moiety probably provides a binding site for the complement.
D000327:Adsorption; D000595:Amino Acid Sequence; D001665:Binding Sites; D055598:Chemical Phenomena; D002621:Chemistry; D003168:Complement Fixation Tests; D003165:Complement System Proteins / Q000378:metabolism*; D006461:Hemolysis; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism*; D011485:Protein Binding; D013329:Structure-Activity Relationship
D007074:Immunoglobulin G; D003165:Complement System Proteins