title: [Virucidal efficacy of a chemical instrument surface disinfectant ("Gigasept") against coxsackie virus type B3. II. Investigation in the instrumental surface test (author's transl)].
abstract: The virucidal efficacy of the chemical disinfectant "Gigasept" on the basis of succine dialdehyde and formaldehyde was tested with an instrumental surface test which was elaborated for the control of instrument-surface disinfectants. These must be able to inactivate viruses on plastics, rubber and metal. Therefore, PVC tubes, PVC dental suction tubes, red rubber catheter and aluminium surfaces were included in this investigation. Coxsackie virus type B3 served as test virus. The surfaces were coated with liquid virus suspensions with the exemption of the aluminium surface which was contaminated with a gelatinous virus suspension. The instrumental surface test procedure enabled not only the analysis of the specific virucidal effect but also the evaluation of the unspecific virus adsorption onto the surface as well as the unspecific virus resuspension from the surface. Parameter for the disinfectant activity was the virus inactivation kinetic, i.e. the interdependence of the titer reduction vs. disinfectant contact time of a 5% solution of "Gigasept". An optimal disinfection must gain absence of virus, a titer reduction of larger than or equal to 103ID 50 and a significant titer decrease of p less than 0.0001. According to these criteria an optimal disinfection was achieved with a 5% Gigasept concentration after 4 hours. The different surfaces did not influence the virucidal activity of the disinfectant. The results of the instrumental surface tests confirmed those of the suspension test.
mesh_terms: D004202:Disinfectants / Q000494:pharmacology*; D004770:Enterovirus / Q000187:drug effects*; D008670:Metals; D010969:Plastics; D012408:Rubber
chemical_list: D004202:Disinfectants; D008670:Metals; D010969:Plastics; D012408:Rubber
vernacular_title: Modellversuche zur Beurteilung der Viruzidie chemischer Instrumentendesinfektionsmittel, am Beispiel von "Gigasept" gegenüber dem humanpathogenen Coxackievirus Typ B3 II. Untersuchungen im Keimträgerversuch