title: Quantitative changes in insoluble collagen during ontogeny in rodents (collagen type I and type III).
abstract: It has been proved in three rodent species that in the insoluble collagen fraction which accumulates in skin collagen with age of the two categories of collagen present (collagen type I and collagen type III), their proportion alters in favour of collagen type I with the advancing age. Since it has also been shown that collagen type I is less resistant towards proteolytic cleavage than is collagen type III its accumulation can be explained either by rapidly advancing cross-linking of this collagen type or more likely by different proteosynthesis. The second alternative is preferred since a step-wise polymerization of collagen type III was also observed. No information revealing to what extent the lysine derived cross-links can combine both collagen types is at present available. On the basis of this information the rapid decrease in insoluble collagen in very early ontogeny (rats below 8 weeks of age) is explained.
mesh_terms: D000375:Aging; D000818:Animals; D002266:Carboxymethylcellulose Sodium; D002845:Chromatography; D002847:Chromatography, Agarose; D003094:Collagen / Q000032:analysis / Q000302:isolation & purification; D006224:Cricetinae; D003488:Cyanogen Bromide; D004591:Electrophoresis, Polyacrylamide Gel; D008297:Male; D051379:Mice; D010455:Peptides / Q000032:analysis; D051381:Rats; D012867:Skin / Q000032:analysis; D012995:Solubility
chemical_list: D010455:Peptides; D003094:Collagen; D002266:Carboxymethylcellulose Sodium; D003488:Cyanogen Bromide