title: The release of alanine by rat diaphragm muscle in vitro.
abstract: Alanine release by rat diaphragm muscle in vitro is stimulated by glutamate, valine, leucine and glucose. The stimulation by glutamate and valine (but not leucine) is inhibited by 3-mercaptopicolinate. These results suggest a metabolic route involving phosphoenolpyruvate carboxykinase which directs amino acid carbon skeletons towards pyruvate synthesis for alanine formation.
mesh_terms: D000409:Alanine / Q000096:biosynthesis*; D000818:Animals; D003964:Diaphragm / Q000187:drug effects / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D005971:Glutamates / Q000378:metabolism; D007930:Leucine / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000187:drug effects / Q000378:metabolism*; D010729:Phosphoenolpyruvate Carboxykinase (GTP) / Q000378:metabolism; D051381:Rats; D013438:Sulfhydryl Compounds / Q000494:pharmacology; D014633:Valine / Q000378:metabolism
chemical_list: D005971:Glutamates; D013438:Sulfhydryl Compounds; D010729:Phosphoenolpyruvate Carboxykinase (GTP); D007930:Leucine; D014633:Valine; D005947:Glucose; D000409:Alanine