Evaluation of a breast cyst fluid protein detectable in the plasma of breast carcinoma patients.
A radioimmunoassay has been developed for one of the major proteins isolated from human breast cyst fluid. Immunologically this protein is identical to a protein present in both human milk and saliva. Ninety-two normal women had plasma levels of this protein below 100 ng/ml (range 7-81 ng/ml; mean 31 ng/ml), and 85% had plasma levels below 50 ng/ml. More than one-half of the women with active gross cystic disease of the breast had plasma levels above 50 ng/ml. None of these women, however, had plasma levels above 150 ng/ml. A significant percentage of women with advanced breast carcinoma have been found to have plasma concentrations of this protein greater than 150 ng/ml.
D000328:Adult; D000368:Aged; D001798:Blood Proteins / Q000032:analysis*; D001940:Breast / Q000473:pathology; D001941:Breast Diseases / Q000097:blood* / Q000473:pathology; D001943:Breast Neoplasms / Q000097:blood* / Q000473:pathology; D003560:Cysts / Q000097:blood* / Q000473:pathology; D005260:Female; D006023:Glycoproteins / Q000097:blood; D006801:Humans; D008207:Lymphatic Metastasis; D008408:Mastectomy; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000097:blood; D011863:Radioimmunoassay
D001798:Blood Proteins; D006023:Glycoproteins