title: The acid perfusion test. A study in patients with symptomatic hiatus hernia, and of the effect of a modified Belsey MK IV repair on the test.
abstract: Acid perfusion with 0.1 n HC1 (5 ml/min for max. 30 min) and simultaneous intragastric instillation of equimolar amounts of sodium bicarbonate were performed in 55 patients with sliding hiatus hernia and symptoms attributable to gastro-oesophageal reflux. Acid perfusion reproduced the patient's spontaneous symptoms, and was thus positive, in 44 per cent of the cases. A positive acid perfusion test means that the patient's spontaneous symptoms may be of oesophageal origin, whereas a negative test does not allow any conclusions. The acid perfusion test was likewise performed before and three months after a modified Belsey MK IV repair in 37 patients with hiatal hernia and symptoms indicating surgical repair. The operation was followed by a reduction in oesophageal acid sensitivity (p less than 0.01).
mesh_terms: D000328:Adult; D000368:Aged; D001639:Bicarbonates; D005260:Female; D005764:Gastroesophageal Reflux / Q000175:diagnosis*; D006548:Hernia, Diaphragmatic / Q000601:surgery*; D006551:Hernia, Hiatal / Q000601:surgery*; D006801:Humans; D006851:Hydrochloric Acid; D008297:Male; D008875:Middle Aged; D010477:Perfusion
chemical_list: D001639:Bicarbonates; D006851:Hydrochloric Acid