Cytotoxic and tumor inhibitory agent from Polygala macradenia Gray (Polygalaceae): 4'-demethyldeoxypodophyllotoxin.
The chloroform fraction of Polygala macradenia exhibited activity against the P-388 lymphocytic leukemia and human epidermoid carcinoma of the nasopharynx test systems. The constituent responsible for this activity was a lignan, 4'-demethyldeoxypodophyllotoxin (C21H20O7). The identity was proven by elemental analysis; PMR, IR, mass spectrometric, and melting-point determinations; and preparation of a derivative.
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D002478:Cells, Cultured; D007942:Leukemia, Experimental / Q000188:drug therapy; D009374:Neoplasms, Experimental / Q000188:drug therapy; D010946:Plants, Medicinal / Q000032:analysis*; D011034:Podophyllotoxin / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology
D000972:Antineoplastic Agents, Phytogenic; D011034:Podophyllotoxin