title: Plasma fibrinogen, cholinesterase activity, and anemia: utility of fibrinogen in multiphasic screening and in assessing the activity of diseases.
abstract: I present the general pattern relationship between (a) plasma fibrinogen and cholinesterase activity and (b) plasma fibrinogen and hemoglobin, in 250 and 310 hospitalized adults, respectively. Although responses of cholinesterase were often unrelated to fibrinogen, when its activity in plasma was depressed, above-normal fibrinogen concentrations were present in about 90% of the subjects. Further, despite the observed independence of hemoglobin and fibrinogen concentrations, whenever frank anemia was present (hemoglobin less than 110 to 120 g/liter), hyperfibrinogenemia was also present in about 75-85% of such anemic patients. Thus, these studies affirm that fibrinogen determination would be an appropriate component of tests on hospital admission and also that hyperfibrinogenemia is a very sensitive "acute phase" reactant, and an important reaction for gauging the course of numerous disorders.
mesh_terms: D000208:Acute Disease; D000328:Adult; D000740:Anemia / Q000175:diagnosis; D002802:Cholinesterases / Q000097:blood*; D005340:Fibrinogen / Q000032:analysis*; D006452:Hemoglobinometry; D006801:Humans; D009098:Multiphasic Screening
chemical_list: D005340:Fibrinogen; D002802:Cholinesterases