Effect of antibiotics of chemotaxis of human leukocytes.
The effect of 20 different antibiotics on chemotaxis by human neutrophils was studied. Human leukocytes incubated with chloramphenicol, rifampin, sodium fusidate, and tetracyclines in vitro showed markedly depressed migration. The mechanisms by which these antibiotics affect leukotaxis are discussed.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D002701:Chloramphenicol / Q000494:pharmacology; D005672:Fusidic Acid / Q000494:pharmacology; D006801:Humans; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology*; D012293:Rifampin / Q000494:pharmacology; D013754:Tetracyclines / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D013754:Tetracyclines; D005672:Fusidic Acid; D002701:Chloramphenicol; D012293:Rifampin