[Impairment of humoral immunity in aging].
1) Aging is associated with a hypergammaglobulinemia consistng of an increase in the serum IgG and IgA, plus a reduction in the IgM. This is associated with an increase of the B lymphocyte circulating pool, and an increase of the ratio IgG-B cells; 2) There is a reduction of the serum concentration of natural isoagglutinins. 3) The secondary IgG response against diphteria toxin (DT) is similar in 15 young and 15 old subjects. 4) There is a reduction of the IgE response against DT in old subjects.
D000368:Aged; D000375:Aging; D000917:Antibody Formation; D004166:Diphtheria Antitoxin / Q000494:pharmacology; D004406:Dysgammaglobulinemia / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A; D007073:Immunoglobulin E / Q000378:metabolism; D007074:Immunoglobulin G / Q000378:metabolism; D007075:Immunoglobulin M
D004166:Diphtheria Antitoxin; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007073:Immunoglobulin E
Altération de l'immunité humorale au cours du vieillissement