Release of VIP by calcium stimulation.
Calcium has been shown to be a reliable releaser of VIP, as has been observed with most peptide hormones. VIP is released throughthe gastrointestinal tract. The challenge of VIP release by calcium could reveal different "potentials" in the production of the hormone, that are not appreciated in the basal state. Calcium stimulation thus showed a slightly greater level of VIP release from the pancreaticoduodenal vein than from the portal radicals. But although the significance of this finding remains to be defined, calcium release could have a clinical applicability in the challenge of equivocal VIPomas.
D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D004064:Digestive System / Q000187:drug effects* / Q000378:metabolism; D004285:Dogs; D005768:Gastrointestinal Hormones / Q000378:metabolism*; D013268:Stimulation, Chemical; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism*
D005768:Gastrointestinal Hormones; D014660:Vasoactive Intestinal Peptide; D002118:Calcium