Studies on fatty acid omega-oxidation. Antiketogenic effect and gluconeogenicity of dicarboxylic acids.
1. Administration of dicarboxylic acids to starving rats decreased the concentration of ketone bodies in the blood. 2. Incorporation of 14C into blood glucose was greater from dicarboxylic acids than from monocarboxylic acids. 3. These results suggest that omega-oxidation may be important for production of succinyl-CoA from fatty acids. 4. In starving or diabetic rats about 15% of palmitic acid were subjected to omega-oxidation and then beta-oxidation.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000097:blood*; D003998:Dicarboxylic Acids / Q000378:metabolism* / Q000494:pharmacology; D005227:Fatty Acids / Q000378:metabolism; D007657:Ketone Bodies / Q000097:blood*; D008297:Male; D051381:Rats; D013217:Starvation
D001786:Blood Glucose; D003998:Dicarboxylic Acids; D005227:Fatty Acids; D007657:Ketone Bodies