Enflurane metabolism and postoperative renal function.
Inorganic fluoride concentrations in blood and urine were measured in 22 gynaecological patients during and after anaesthesia with enflurane and post-operative renal function was investigated. Ten patients (group I) were given 0.6 vol.% enflurane, and 12 patients (group II) a mixture of 0.6 and 0.8 vol.% enflurane. The serum fluoride concentration of arterial blood reached, in group I, after 120 min 18,99 micronmol/1 whereas in group II the concentration was 21 micronmol/1. One hour after the end of anaesthesia the fluoride concentration in venous blood were nearly identical in both groups and decreased in the following 12 h evenly. In all patients relatively high postoperative fluoride concentrations were observed in the urines. No evidence of renal dysfunction was found after anaesthesia.
D000328:Adult; D001158:Arteries; D004737:Enflurane / Q000378:metabolism / Q000494:pharmacology*; D005260:Female; D005459:Fluorides / Q000097:blood* / Q000652:urine; D006801:Humans; D007044:Hysterectomy; D007668:Kidney / Q000187:drug effects*; D008738:Methyl Ethers / Q000494:pharmacology*; D008875:Middle Aged; D013997:Time Factors; D014680:Veins
D008738:Methyl Ethers; D004737:Enflurane; D005459:Fluorides