Failure of poxvirus replication in the presence of an inhibitor of nucleolar RNA synthesis.
In vaccinia virus infected cells the appearance of a late enzyme RNA polymerase was prevented by MPB, an inhibitor of nucleolar RNA synthesis, although inductions of the early enzymes thymidine kinase and DNA polymerase were not affected. It is inferred the nucleoli may be involved in the replication of vaccinia virus.
D001562:Benzimidazoles / Q000494:pharmacology*; D002466:Cell Nucleolus / Q000187:drug effects / Q000378:metabolism; D004259:DNA-Directed DNA Polymerase / Q000096:biosynthesis; D012321:DNA-Directed RNA Polymerases / Q000096:biosynthesis; D004790:Enzyme Induction / Q000187:drug effects; D006367:HeLa Cells; D012334:RNA, Neoplasm / Q000096:biosynthesis; D013438:Sulfhydryl Compounds / Q000494:pharmacology*; D013937:Thymidine Kinase / Q000096:biosynthesis; D014616:Vaccinia virus / Q000254:growth & development*; D014779:Virus Replication / Q000187:drug effects*
D001562:Benzimidazoles; D012334:RNA, Neoplasm; D013438:Sulfhydryl Compounds; D013937:Thymidine Kinase; D012321:DNA-Directed RNA Polymerases; D004259:DNA-Directed DNA Polymerase