Regional acetylcholine content in mouse brain after morphine tablet implantation.
Implantation of a 75 mg morphine tablet in mice caused a significant decrease in the body weight and hypothermia. After 3 days, the concentration of acetylcholine decreased in all brain regions with the exception of the cerebellum. A significant decrease in acetylcholine content was observed in the midbrain, corpus striatum and the cerebral cortex 3 days after implantation. It is postulated that the decrease in Ach content is due to an increased release of acetylcholine as a result of development of tolerance to morphine.
D000109:Acetylcholine / Q000032:analysis*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects*; D004343:Drug Implants; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009020:Morphine / Q000008:administration & dosage / Q000494:pharmacology*; D013607:Tablets; D013997:Time Factors
D004343:Drug Implants; D013607:Tablets; D009020:Morphine; D000109:Acetylcholine