Effects and residues of dietary hexachlorobenzene in growing swine.
Crossbred weanling gilts were fed a standard ration containing 0, 1, 10, or 100 ppm purified hexachlorobenzene (HCB) for 13 wk. No mortalities, ill health, neurological disorders, or significant depressions in weight gain were observed. Postmortem examination revealed brightly fluorescent livers at all levels of HCB. The group receiving 100 ppm had a tendency for smaller spleens, larger livers with swollen hepatocytes, and decreased lymphocytes. HCB accumulated in the dissectable fat of growing swine to concentrations five- to sevenfold higher than the dietary concentration; residues in 11 other tissues examined were below the dietary concentration.
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D001772:Blood Cell Count; D002722:Chlorobenzenes / Q000494:pharmacology*; D002849:Chromatography, Gas; D004032:Diet; D005260:Female; D006581:Hexachlorobenzene / Q000032:analysis / Q000378:metabolism / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D010573:Pesticide Residues / Q000032:analysis / Q000378:metabolism*; D013552:Swine; D013997:Time Factors
D002722:Chlorobenzenes; D010573:Pesticide Residues; D006581:Hexachlorobenzene