title: [Nontuberculous infectious osteoarthritis in adults (excluding spondylodiscitis) in rheumatology].
abstract: Analysis of twenty five personal observations of septic osteoarthritis compared with information from the literature led the authors to the following conclusions: 1) Diagnosis of septic osteo-arthritis must be considered when confronted with a picture of acute or subacute arthritis generally inflamed with variable fever, raised sedimentation rates and frequently polymorph neutrophilia, above all especially if there are particular antecedents (local trauma or intra-articular injection, conditions which favor infections: diabetes, alcoholism, impaired immunity, corticosteroid therapy or various therapeutic immuno-suppresives). 2) It may be established on absolute criteria (isolation of the organism at the site of the lesions) or, in the absence of direct bacteriological evidence, by a body of evidence amongst which 4 arguments are of particular value: identification of a pathogenic organism in one or more blood cultures and/or at the site of a closed infection, postive serology and particularly elevation of the antistaphylolysine titres, rapid-onset radiological changes of destruction and/or reconstruction. plus hypercellularity of the fluid greater than 100,000 cells/mm3. 3) Medical treatment sometimes includes local treatment (joint aspiration, local injection of antibiotics) and in all cases immobilisation during the acute phase and systemic antibiotics. The latter will vary according to the organism responsible and its sensitivity. It seems useful to continue this for twelve weeks at the minimum in the normal form, initially making use of the combination of 2 antibiotics and preferably using continuous perfusion and/or intramuscular routes during the first half of treatment. 4) The consistently good results of such medical treatment seem to limit considerably the place of surgery for which the indications have become rare during the acute phase and even more so at later stages.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000989:Antistreptolysin / Q000032:analysis; D001170:Arthritis, Infectious / Q000175:diagnosis / Q000188:drug therapy; D001769:Blood / Q000382:microbiology; D001799:Blood Sedimentation; D001831:Body Temperature; D005260:Female; D006801:Humans; D007103:Immobilization; D007270:Injections, Intra-Articular; D008297:Male; D008875:Middle Aged; D009504:Neutrophils; D012446:Sacroiliac Joint; D013582:Synovial Fluid / Q000166:cytology
chemical_list: D000900:Anti-Bacterial Agents; D000989:Antistreptolysin
vernacular_title: Ostéo-arthrites infectieuses non tuberculeuses de l'adulte (spondylodiscites exceptées) en milieu rhumatologique