[Activity of coenzyme A and N-acetyltransferase during tumor growth].
The activity of acetylation of sulphadimezine in C57B1/He mice with the low spontaneous tumour incidence was significantly lower than in the C3H/Sn mice with high spontaneous tumour incidence. The development of malignant melanoma B-16 in the C57B1/He mice led to increase in the activity of the sulphadimezine acetylation. Along with the previously obtained information, these data indicated the relationship between the development of tumour process and changes in the activity of the enzyme N-acetyltransferase. No difference in the acetylation of the sulphaylamide was found in the same groups of mice; this points to the absence of any differences in the coenzyme A level.
D000123:Acetyltransferases / Q000378:metabolism*; D000818:Animals; D003065:Coenzyme A / Q000378:metabolism*; D005260:Female; D008545:Melanoma / Q000201:enzymology / Q000378:metabolism*; D051379:Mice; D009368:Neoplasm Transplantation; D013045:Species Specificity; D013418:Sulfamethazine / Q000378:metabolism; D013424:Sulfanilamides / Q000378:metabolism; D014184:Transplantation, Homologous
D013424:Sulfanilamides; D013418:Sulfamethazine; D000123:Acetyltransferases; D003065:Coenzyme A
Aktivnost' koénzima A i N-atsetiltransferazy pri opukholevom roste