Xanthine oxidase activity in a gouty patient with partial deficiency of HGPRT.
A patient with juvenile gout and partial deficiency of HGPRT is presented. In this subject, hepatic xanthine oxidase activity showed a twelve-fold increase. Xanthine oxidase is a readily induced enzyme and this increased activity is probably correlated with the increased availability of hypoxanthine observed in such patients.
D006073:Gout / Q000201:enzymology*; D006801:Humans; D007041:Hypoxanthine Phosphoribosyltransferase / Q000172:deficiency*; D008099:Liver / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D014969:Xanthine Oxidase / Q000378:metabolism*
D014969:Xanthine Oxidase; D007041:Hypoxanthine Phosphoribosyltransferase