The incorporation of tritiated uridine in hair germ and dermal papilla during dormancy (telogen) and activation (early anagen).
During dormancy there is very little incorporation of [3H]uridine in cells of hair germ and dermal papilla. During activation (both spontaneous and experimental) there is a marked increase in this parameter, expecially in the cells of the germ. After experimental activation by plucking, the increase in label in the germ is evident by 6 hr, reaching an initial maximum by 24 hr. The initial increase in [3H]uridine incorporation after activation precedes the increase in [3H]thymidine incorporation found previously, by about 6 hr. No evidence was found that the increase in [3H]uridine of papilla cells precedes the increase in [3H]uridine of germ cells. This finding militates against the possibility that the dermal papilla is triggered into an inductive role (vis-á-vis the germ cells) by means of circulating steroid hormones.
D000818:Animals; D006197:Hair / Q000254:growth & development / Q000378:metabolism*; D006204:Hair Removal; D051379:Mice; D008809:Mice, Inbred C3H; D010507:Periodicity; D012313:RNA / Q000096:biosynthesis; D012867:Skin / Q000378:metabolism*; D014316:Tritium; D014529:Uridine / Q000378:metabolism*
D014316:Tritium; D012313:RNA; D014529:Uridine