MAO inhibition, an unlikely mode of action for chlordimeform.
Inhibition constants of several formamidines, their corresponding formanilides and other representatives of compounds derived from aniline, such as phenylureas, N-phenyl-carbamates and acylanilides, were determined for rat liver monoamine oxidase. The reversability of the inhibition and the lack of correlation between inhibition potencies and toxicities of the compounds tested add to the opinion that MAO inhibition is not a prominent factor in chlordimeform poisoning.
D000578:Amidines / Q000494:pharmacology*; D000813:Anilides / Q000494:pharmacology; D000818:Animals; D002742:Chlorphenamidine / Q000494:pharmacology*; D066298:In Vitro Techniques; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology*; D008996:Monoamine Oxidase Inhibitors; D051381:Rats; D013329:Structure-Activity Relationship
D000578:Amidines; D000813:Anilides; D008996:Monoamine Oxidase Inhibitors; D002742:Chlorphenamidine