Serum creatine kinase isoenzymes in Duchenne muscular dystrophy.
Creatine kinase isoenzymes in sera of 51 patients with Duchenne muscular dystrophy were separated on a micro-column of DEAE Sephadex A-50. MB isoenzyme was detected in the sera of 32 cases (63%). MB percentage of total creatine kinase activity correlated significantly with urinary creatine/creatinine ratio in the early stages of the disease. No close relationship between MB levels and ECG findings was observed. The origin of serum MB in Duchenne dystrophy is discussed.
D000293:Adolescent; D000328:Adult; D002648:Child; D003401:Creatine / Q000652:urine; D003402:Creatine Kinase / Q000097:blood* / Q000302:isolation & purification; D003404:Creatinine / Q000652:urine; D004562:Electrocardiography; D006801:Humans; D007527:Isoenzymes / Q000097:blood* / Q000302:isolation & purification; D009136:Muscular Dystrophies / Q000201:enzymology* / Q000503:physiopathology
D007527:Isoenzymes; D003404:Creatinine; D003402:Creatine Kinase; D003401:Creatine