[Characteristics of streptomycin distribution and binding in the body of rabbits depending on their immunobiological state].
Some regularities of distribution and binding of streptomycin in the blood, organs and tissues of immunized rabbits werer studied. The leveles of the bound and free antibiotic in ther were determined. It was found that the immunobiological state of the rabbits had a definite effect on the distribution character and binding of streptomycin with proteins and cells in the animal organs and tissues. These changes were most pronounced in the organs and tissues of lymphoid and hematopoietic systems, the cells of which are indirect active participants of the immunity formation. As a result of proliferation of these cells the antibiotic was accumulated in higher amounts and bound more actively especially in the thymus gland and bone marrow, the central organs of the immunological reconstruction of the host. The studies are indicative of the presence of interaction between immunogenesis, distribution and binding of streptomycin in immunized animals.
D000373:Agglutinins / Q000032:analysis; D000818:Animals; D000942:Antigens, Bacterial / Q000008:administration & dosage; D001667:Binding, Competitive / Q000187:drug effects; D001702:Biopharmaceutics; D005609:Free Radicals; D007114:Immunization; D011485:Protein Binding / Q000187:drug effects; D011817:Rabbits / Q000276:immunology*; D012482:Salmonella paratyphi A / Q000276:immunology; D013307:Streptomycin / Q000276:immunology / Q000378:metabolism*; D013997:Time Factors
D000373:Agglutinins; D000942:Antigens, Bacterial; D005609:Free Radicals; D013307:Streptomycin
Osobennosti raspredeleniia is sviazyvaniia streptomitsina v organizme krolikov v zavisimosti ot ego immunobiologicheskogo sostoianiia