Complete HLA and Bf typing in families. II. Bf and the structure of the HLA region.
In two families with HLA-A,B cross-overs, the Bf locus followed the segregation of HLA-A rather than HLA-B as expected. These data, when analyzed together with those in the literature suggest that two different sequences of HLA genes exist in the population: one with Bf close to HLA-D and another with Bf in the HLA-A region.
D003922:Diabetes Mellitus, Type 1 / Q000235:genetics / Q000276:immunology*; D005260:Female; D006680:HLA Antigens / Q000032:analysis; D006649:Histocompatibility Antigens / Q000032:analysis; D006720:Homozygote; D006801:Humans; D007125:Immunogenetics; D008297:Male; D010375:Pedigree; D011995:Recombination, Genetic
D006680:HLA Antigens; D006649:Histocompatibility Antigens