[Effect of exogenous superoxide dismutase and 1,4-diazobicyclo-(2,2,2,)-octane on the resistance of mice to acute oxygen poisoning].
Single injection to mice of a perified preparation of superoxide dismutase (1000 units, intravenously) combined with catalase (0.5 mg) or without it failed to protect from the toxic action of 100% oxygen under the pressure of 5 ata. 1,4-diazobicyclo (2.2.2) octane (6 mg, intraperitoneally) increased the preconvulsive survival period of mice under these conditions. The formation of single oxygen under hyperoxia in vivo is supposed.
D000208:Acute Disease; D000818:Animals; D001391:Azo Compounds / Q000627:therapeutic use*; D001643:Bridged Bicyclo Compounds / Q000627:therapeutic use*; D001952:Bridged-Ring Compounds / Q000627:therapeutic use*; D051379:Mice; D010100:Oxygen / Q000506:poisoning*; D013482:Superoxide Dismutase / Q000627:therapeutic use*
D001391:Azo Compounds; D001643:Bridged Bicyclo Compounds; D001952:Bridged-Ring Compounds; D013482:Superoxide Dismutase; D010100:Oxygen
Vliianie ékzogennoĭ superoksiddismutazy i 1,4-diazobitsiklo-(2,2,2)-oktana na ustoĭchivost' mysheĭ k ostroí kislorodnoĭ intoksikatsii