Prostaglandin and thromboxane biosynthesis inhibitors.
All acidic non-steroidal anti-inflammatory drugs suppress the activity of microsomal cyclo-oxygenase of arachidonic acid; therefore, these drugs are equipotent inhibitors of prostaglandin and thromboxane generation. A non-acidic anti-inflammatory agent, 1'-(isopropyl-2-indolyl)-3-pyridyl-3-ketone (L 8027), selectively inhibits biosynthesis of thromboxane A2 in blood platelets and in lungs.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D001792:Blood Platelets / Q000378:metabolism; D006801:Humans; D006880:Hydroxy Acids / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D007211:Indoles / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D011448:Prostaglandin Antagonists / Q000494:pharmacology*; D011714:Pyrans / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D011725:Pyridines / Q000494:pharmacology; D011817:Rabbits
D000893:Anti-Inflammatory Agents; D006880:Hydroxy Acids; D007211:Indoles; D011448:Prostaglandin Antagonists; D011714:Pyrans; D011725:Pyridines