Neutrophil accumulation in vivo following the administration of chemotactic factors.
Intravenously administered 51Cr-labelled homologous neutrophils accumulated at guinea-pig skin sites prepared by intradermal injection of factors derived from complement-activated serum, possessing in vitro chemotactic activity. There was a strong correlation between the in vitro potency of Sephadex G-100 fractions of the activated serum and their ability to evoke neutrophil accumulation in vivo. These experiments suggest that agents which are chemotactic for neutrophils in vitro also induce the localization of this cell in vivo.
D000818:Animals; D002634:Chemotaxis, Leukocyte; D003165:Complement System Proteins; D005260:Female; D006168:Guinea Pigs; D007271:Injections, Intradermal; D007958:Leukocyte Count; D008297:Male; D009504:Neutrophils / Q000502:physiology*; D012867:Skin / Q000166:cytology
D003165:Complement System Proteins