[Clinical and pharmacokinetic studies in patients with digitalis intoxication (author's transl)].
6 patients with severe digitalis intoxication were studied while hospitalised in a coronary care unit. 2 and 4 patients had ingested high doses of lanatosid C and digoxin, respectively. In three cases ventricular arrhythmias, in one of these and two further cases SA blocking and an additional A-V-block in one case were observed. Maximum blood levels of digoxin between 3.4 and 20 ng/ml were determined several hours after the ingestion. The maximal blood levels were achieved in one patient only 52 h after ingesting lanatosid C and in one patient taking digoxin after 12.5 h. Potassium concentrations in plasma were elevated in 4 patients. Antiarrhythmic and electrolyte therapy is discussed and the usefulness of a stomach lavage for diminishing the quantity of absorbed lanatosid C is shown in one patient who had a maximal blood level of 3.4 ng/ml after taking 23.7 mg of lanatosid C. Cumulative urinary excretion of this patient was 0.68 mg within 5.5 days. This result confirms the minimal enteral absorption under the therapy chosen.
D000328:Adult; D000368:Aged; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D004071:Digitalis Glycosides / Q000378:metabolism / Q000506:poisoning* / Q000627:therapeutic use; D004077:Digoxin / Q000506:poisoning; D005260:Female; D006327:Heart Block / Q000139:chemically induced; D006801:Humans; D007408:Intestinal Absorption; D007700:Kinetics; D007799:Lanatosides / Q000506:poisoning; D008297:Male; D008875:Middle Aged; D011041:Poisoning / Q000628:therapy
D004071:Digitalis Glycosides; D007799:Lanatosides; D004077:Digoxin
Klinische und pharmakokinetische Untersuchungen zur Digitalisintoxikation