title: The association of HLA antigens A3, B7, and DW2 with 330 multiple sclerosis patients in the United States.
abstract: Reported associations of HLA antigens with MS have varied considerably. In this study we have examined 330 clinically definite MS patients from the United States. The frequency of DW2 (52%) was highly statistically significant in MS patients as compared to controls (p less than 0.00001). Neither A3 nor B7 was significantly increased in MS; however, the joint occurrences of A3-DW2 (20% vs 7%, p less than 0.001) and B7-DW2 (30% vs 13%, p less than 0.0002) are highly associated with MS.
mesh_terms: D002874:Chromosome Mapping; D005787:Gene Frequency; D006680:HLA Antigens / Q000032:analysis*; D006649:Histocompatibility Antigens / Q000032:analysis*; D006650:Histocompatibility Testing; D006801:Humans; D009103:Multiple Sclerosis / Q000276:immunology*; D014481:United States
chemical_list: D006680:HLA Antigens; D006649:Histocompatibility Antigens