[Inhibition of urease by hypoglycaemic drugs (author's transl)].
The effect of oral hypoglycaemic drugs (derived from sulphonylurea) on urease activity in the quantitative determination of urea has been studied. These compounds have been found to produce a competitive inhibition of enzyme activity with respect to substrate. Possible interference of these antidiabetic agents upon urea analysis is discussed.
D002747:Chlorpropamide / Q000494:pharmacology*; D014044:Tolbutamide / Q000494:pharmacology*; D014510:Urease / Q000037:antagonists & inhibitors* / Q000097:blood
D014044:Tolbutamide; D014510:Urease; D002747:Chlorpropamide
Inhibición de la ureasa por fármacos hipoglucemiantes derivados de la sulfonilurea