Effect of antidiarrheal and antimotility drugs on ileal excreta.
Commonly used antimotility and antidiarrheal drugs were administered to six ileostomized subjects to determine whether their normal ileal excreta and that induced by prune juice could be altered. A total of 49 studies were performed, 21 with and 28 without prune juice. Bismuth subgallate was the only drug which significantly reduced the normal ileal excreta (P less than 0.05). Codeine sulfate decreased the ileal excreta in two of three subjects in either type of study. The third subject was a nonresponder to drugs. Deodorized tincture of opium (DTO) and diphenoxylate (Lomotil) were also effective in some subjects. Propantheline, tincture of belladonna, Sorboquel, and Kaopectate did not appear to decrease ileal excreta. Calcium carbonate, on the other hand, increased ileal excreta; fat excretion was also increased.
D000328:Adult; D000368:Aged; D000930:Antidiarrheals / Q000494:pharmacology*; D001533:Belladonna Alkaloids / Q000494:pharmacology; D001729:Bismuth / Q000494:pharmacology; D002119:Calcium Carbonate / Q000494:pharmacology; D003061:Codeine / Q000494:pharmacology; D004157:Diphenoxylate / Q000494:pharmacology*; D005260:Female; D005638:Fruit; D005769:Gastrointestinal Motility / Q000187:drug effects; D006801:Humans; D007081:Ileostomy; D007082:Ileum / Q000187:drug effects / Q000503:physiopathology*; D007419:Intestinal Secretions / Q000187:drug effects; D007540:Isonipecotic Acids / Q000494:pharmacology*; D007616:Kaolin / Q000494:pharmacology; D008297:Male; D009892:Opium / Q000494:pharmacology*; D010276:Parasympatholytics / Q000494:pharmacology*; D011413:Propantheline / Q000494:pharmacology; D014882:Water-Electrolyte Balance
D000930:Antidiarrheals; D001533:Belladonna Alkaloids; D007540:Isonipecotic Acids; D010276:Parasympatholytics; D011413:Propantheline; D007616:Kaolin; D004157:Diphenoxylate; D009892:Opium; D002119:Calcium Carbonate; D001729:Bismuth; D003061:Codeine