Results of reflex photometric determinations of vasoconstriction after topical steroid application. Tachyphylaxis, relative and absolute refractory phase after single and multiple application of steroid.
After a repeated intensive topical application (4-h rhythm), there it is phase already after 28 h in which the cutaneous vessels are insensitive (refractory) to constrictor stimuli due to steroids. This refractory phase lasts for at least 68 h. A single local application of steroid likewise leads to a diminished vasoreactivity for a limited time. The relative refractory phase is limited to 96 h under the given experimental conditions.
D000287:Administration, Topical; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000378:metabolism; D005260:Female; D005938:Glucocorticoids; D006801:Humans; D008297:Male; D010783:Photometry; D012867:Skin / Q000098:blood supply*; D012869:Skin Absorption; D013618:Tachyphylaxis; D013997:Time Factors; D014666:Vasomotor System / Q000187:drug effects*
D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids