Preparation and antitumor activity of o-palmitoyldextran phosphates, o-palmitoyldextrans, and dextran phosphate.
Dextran was modified by introduction of palmitoly and phosphate groups. The derivatives were analyzed by sequential periodate oxidation-sodium borohydride reduction. Only one of these derivatives showed a significant growth-inhibitory effect when administered alone, while a second derivative showed, in combination therapy with an ineffective dose of Mitomycin C, a marked synergistic effect.
D000818:Animals; D003911:Dextrans / Q000627:therapeutic use; D004357:Drug Synergism; D008297:Male; D051379:Mice; D008937:Mitomycins / Q000627:therapeutic use; D009943:Organophosphorus Compounds / Q000627:therapeutic use; D010169:Palmitic Acids / Q000627:therapeutic use; D012510:Sarcoma 180 / Q000188:drug therapy*
D003911:Dextrans; D008937:Mitomycins; D009943:Organophosphorus Compounds; D010169:Palmitic Acids