Liquid chromatography in pharmaceutical analysis VI: determination of dantrolene sodium in a dosage form.
Operating conditions are described for the qualitative and quantitative determination of dantrolene sodium by high-pressure liquid chromatography. A 10-mum porous silica column was employed, using carbon tetrachloride-dimethylformamide (90:10) as the mobile phase. The flow rate was 2.0 ml/min (1800 psig), and the peaks were detected at 375 nm. The analysis of a dosage form can be carried out within 30 min with an accuracy of 3.1%. The results agree favorably with those obtained with a modified spectrophotofluorometric method.
D002214:Capsules / Q000032:analysis; D002851:Chromatography, High Pressure Liquid; D003620:Dantrolene / Q000032:analysis*; D006827:Hydantoins / Q000032:analysis*; D013050:Spectrometry, Fluorescence
D002214:Capsules; D006827:Hydantoins; D003620:Dantrolene