Differential effects of opiates on the incorporation of [14C] thiamine in the central nervous system of the rat.
Opiate agonist (morphine), pure antagonist (naloxone), mixed agonist-antagonist (nalorphine) and analgesically inactive enantiomorph (dextrorphan) produced differential stereoselective effects on the incorporation of [14C] thiamine in the central nervous system of the rats. The possible role of thiamine in opiate effects and its implications are discussed.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D001933:Brain Stem / Q000378:metabolism; D002531:Cerebellum / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism; D003917:Dextrorphan / Q000494:pharmacology*; D008297:Male; D009019:Morphinans / Q000494:pharmacology*; D009020:Morphine / Q000494:pharmacology*; D009269:Nalorphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology*; D009928:Organ Specificity; D051381:Rats; D013831:Thiamine / Q000097:blood / Q000378:metabolism*
D009019:Morphinans; D003917:Dextrorphan; D009270:Naloxone; D009020:Morphine; D009269:Nalorphine; D013831:Thiamine