The mechanism of spinal cord cavitation following spinal cord transection. Part 3: Delayed grafting with and without spinal cord retransection.
Cavitation adjacent to transection of spinal cords can be successfully eliminated by a second operation 1 week after the initial spinal cord transection. The second operation consists of removal of the necrotic spinal cord tissue, thus producing a gap. Segments of autogenous sciatic nerve are inserted into the gap between the spinal cord stumps. If the spinal cord is injured by retransection at the second operation, cavitation again occurs in the spinal cord stumps resulting in separation of the nerve grafts from the spinal cord. The results of the present experiments support the concept that lysosomal spinal cord autotomy, which causes spinal cord cavitation, is a self-limiting process and that once the spinal cord has completed the autotomy, the process will not occur again unless the spinal cord is agiain traumatized.
D000818:Animals; D003560:Cysts / Q000209:etiology* / Q000517:prevention & control; D004285:Dogs; D005260:Female; D008247:Lysosomes; D009336:Necrosis; D009410:Nerve Degeneration; D009416:Nerve Regeneration; D012584:Sciatic Nerve / Q000637:transplantation*; D013116:Spinal Cord / Q000473:pathology; D013119:Spinal Cord Injuries / Q000150:complications* / Q000473:pathology / Q000601:surgery; D014182:Transplantation, Autologous