Enhancement of biliary phospholipid radioactivity by intestinal administration of labeled precursors of hepatic lecithin synthesis.
An animal model is used to study the effects of different radioactive precursors of lecithin, administered intestinally, upon biliary lecithin synthesis. Choline caused greater biliary lecithin radioactivity than choline-labeled lecithin or palmitic acid. The clinical application of this finding is discussed with relation to patients with gallstones or potentially lithogenic bile. Oral administration of choline may increase biliary lecithin concentration and, thus, cholesterol-holding capacity in this patient group, thereby changing the character of the bile to a non-lithogenic state.
D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism*; D002250:Carbon Radioisotopes / Q000378:metabolism*; D002769:Cholelithiasis / Q000209:etiology; D002794:Choline / Q000494:pharmacology*; D007267:Injections; D007422:Intestines; D008099:Liver / Q000378:metabolism*; D008954:Models, Biological; D010169:Palmitic Acids / Q000008:administration & dosage / Q000494:pharmacology*; D010713:Phosphatidylcholines / Q000096:biosynthesis; D010743:Phospholipids / Q000096:biosynthesis*; D013552:Swine
D001647:Bile Acids and Salts; D002250:Carbon Radioisotopes; D010169:Palmitic Acids; D010713:Phosphatidylcholines; D010743:Phospholipids; D002794:Choline