title: Dedifferentiation of low grade chondrosarcomas.
abstract: In four unusual cases where a low-grade chondrosarcoma suddenly dedifferentiated into a florid, highly-malignant fibrosarcoma, the average survival was 12 months (range 5-18 months). The surgical treatment of chondrosarcoma consists of a primary excisional biopsy, and if dedifferentiation to fibrosarcoma is seen, radical excision and chemotherapy or irradiation or both.
mesh_terms: D001859:Bone Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D002813:Chondrosarcoma / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D005260:Female; D005354:Fibrosarcoma / Q000401:mortality / Q000473:pathology / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged