title: Effects of cholinomimetic drugs and their antagonists injected into vertebral artery of unanaesthetized dogs.
abstract: In unanaesthetized dogs, cholinomimetic drugs and their antagonists, catecholamines and 5HT were injected into vertebral artery placed in a skin loop. Acetylcholine (1 mg), pilocarpine (1-2 mg), nicotine (250-500 microng), eserine (100 microng) and neostigmine (250 microng) produced sleep apart from a few other peripheral effects. Sleep for longer periods followed injections of tubocurarine (1 mg), atropine (50 microng) and hexamethonium (500 microng). Adrenaline (50 microng) and noradrenaline (50-250 microng) did not produce significant effects on behaviour and sleep. 5HT (250-500 microng) also caused sleep.
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D004285:Dogs; D004569:Electroencephalography; D004837:Epinephrine / Q000494:pharmacology; D006584:Hexamethonium Compounds / Q000494:pharmacology; D007269:Injections, Intra-Arterial; D009043:Motor Activity / Q000187:drug effects; D009388:Neostigmine / Q000494:pharmacology; D009538:Nicotine / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D010277:Parasympathomimetics / Q000008:administration & dosage* / Q000037:antagonists & inhibitors / Q000494:pharmacology; D010830:Physostigmine / Q000494:pharmacology; D010862:Pilocarpine / Q000494:pharmacology; D012701:Serotonin / Q000031:analogs & derivatives; D012890:Sleep / Q000187:drug effects*; D014403:Tubocurarine / Q000494:pharmacology; D014711:Vertebral Artery
chemical_list: D006584:Hexamethonium Compounds; D010277:Parasympathomimetics; D010862:Pilocarpine; D012701:Serotonin; D009388:Neostigmine; D009538:Nicotine; D001285:Atropine; D010830:Physostigmine; D000109:Acetylcholine; D014403:Tubocurarine; D009638:Norepinephrine; D004837:Epinephrine