Bovine pancreatic peptide: action on gastric and pancreatic secretion in dogs.
Bovine pancreatic peptide (BPP) is a straight chain peptide containing 36 amino acid residues that has recently been isolated from pancreatic tissue. At a dose of 40 mug/kg-h intravenously, it stimulated gastric acid secretion when given alone but inhibited the submaximal secretion induced by the C-terminal pentapeptide of gastrin. Basal pancreatic secretion of dogs was inhibited by BPP (1-10 mug/kg-h) inhibited pancreatic protein secretion but often showed a biphasic action on water-bicarbonate response, an initial augmentation followed by reduction. BPP (2-5 mug/kg-h) inhibited pancreatic water-bicarbonate and protein secretions induced by an infusion of secretin plus cholecystokinin. Des-tyrosyl-NH2 BPP lacking the C-terminal tyrosyl amide, failed to inhibit gastric acid induced by C-terminal pentapeptide of gastrin or pancreatic secretion induced by secretin. BPP had no hyper- or hypoglycemic, hyperkalemic, or diuretic actions in the dog.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002417:Cattle; D002766:Cholecystokinin / Q000494:pharmacology; D004285:Dogs; D005750:Gastric Juice / Q000378:metabolism*; D005934:Glucagon / Q000494:pharmacology; D010179:Pancreas / Q000378:metabolism*; D010187:Pancreatic Hormones / Q000494:pharmacology*; D010418:Pentagastrin / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology*; D011188:Potassium / Q000378:metabolism; D012633:Secretin / Q000494:pharmacology; D012964:Sodium / Q000378:metabolism; D013270:Stomach / Q000502:physiology
D001786:Blood Glucose; D010187:Pancreatic Hormones; D010455:Peptides; D012633:Secretin; D005934:Glucagon; D002766:Cholecystokinin; D012964:Sodium; D010418:Pentagastrin; D011188:Potassium