Embryotoxicity of bilirubin.
Intraperitoneal injection of bilirubin in a dosage of 25 mg. per kilogram during the days nine to 15 of gestation in bile duct-ligated heterozygous Gunn rats was embryotoxic. Bile duct ligation per se had no gross observable effects on fetal development. Infertility is found in homozygous female Gunn rats that have unconjugated plasma bilirubin concentrations comparable to those achieved in this study (approximately 6.0 mg. per deciliter).
D000818:Animals; D001663:Bilirubin / Q000633:toxicity*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004622:Embryo, Mammalian / Q000187:drug effects*; D005260:Female; D006579:Heterozygote; D006932:Hyperbilirubinemia / Q000139:chemically induced; D007247:Infertility, Female / Q000139:chemically induced; D011247:Pregnancy; D051381:Rats
D001663:Bilirubin