Effects of L-lysine administration on certain aspects of ascorbic acid metabolism in weanling rats.
L-lysine administration to male weanling rats at a dose of 110.4 mg (25% LD50) per 100 g body weight per day for 15 days reduced the liver total ascorbic acid level. The biosynthesis as well as the degradation of L-ascorbic acid was diminished under these conditions. The fall in liver total ascorbic acid level after L-lysine administration was ascribed to its reduced synthesis.
D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008239:Lysine / Q000494:pharmacology*; D008297:Male; D009929:Organ Size; D051381:Rats
D008239:Lysine; D001205:Ascorbic Acid