[The importance of body weight in treatment with digoxin and digoxin derivatives (author's transl)].
A total of 1109 determinations of digoxin concentration in serum were performed in 317 patients with cardiac failure during oral maintenance therapy with digoxin, beta-acetyldigoxin and beta-methyldigoxin. It was shown that the optimal therapeutic serum concentration (1.21 to 1.70 ng/ml) can be obtained reliably if the dosage of digoxin and its derivatives is based on the body weight. The daily doses recommended for oral maintenance therapy are 4mug/kg for beta-methyldigoxin, 5 mug/kg for beta-acetyldigoxin, and 8 mug/kg for digoxin. For initiating cardiac therapy the double maintenance dose can be prescribed once. Digoxin derivatives should be preferred to digoxin when choosing the drug.
D000368:Aged; D001835:Body Weight; D004077:Digoxin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000627:therapeutic use*; D005260:Female; D006333:Heart Failure / Q000188:drug therapy; D006801:Humans; D006980:Hyperthyroidism / Q000150:complications; D008297:Male; D008875:Middle Aged; D012737:Sex Factors
D004077:Digoxin
Bedeutung des Körpergewichts für die Therapie mit Digoxin und Digoxinderivaten