Does "blastocyst estrogen" initiate implantation?
Fertilized eggs were incubated for 2 hours in a medium containing estradiol-17beta and then transferred into the uteri of day 5 pseudopregnant rats. These eggs, but not estrogen-free control eggs, induced a local increase in capillary permeability. We suggest that the blastocyst factor which induces the local increase in capillary permeability during early pregnancy is estrogen synthesized by the blastocyst.
D000818:Animals; D001755:Blastocyst / Q000502:physiology*; D002199:Capillary Permeability / Q000187:drug effects; D010064:Embryo Implantation / Q000187:drug effects*; D004958:Estradiol / Q000494:pharmacology; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D011247:Pregnancy; D011555:Pseudopregnancy; D051381:Rats; D013268:Stimulation, Chemical; D014599:Uterus / Q000098:blood supply
D004967:Estrogens; D004958:Estradiol