Primary arterial ligation in resection of cancer of the colon. Rational and technic.
The dynamics of arterial, venous, and lymphatic flow in the mesentery were studied in dogs, using an electromagnetic flowmeter for the blood and cannulation and gravimetric measurement for the lymph. Ligation of veins caused an increased venous outflow in adjacent veins and a marked increase in lymph flow. When marginal vessels were ligated, eliminating the major collateral flow, venous flow decreased, but elevated lymph flow persisted. Simultaneous ligation of arteries and veins resulted in increases of both arterial and venous flow in adjacent vessels. Lymph flow decreased unless excessive arterial collateral flow persisted. When collateral marginal vessel flow was occluded, adjacent venous and arterial blood flow decreased to control levels. With arterial ligation, collateral arterial blood flow increased slightly, but venous and lymph flow decreased sharply. When collateral marginal vessels were eliminated, adjacent arterial blood flow decreased to control levels and venous flow virtually stopped. As a result of these studies, the technic of early primary arterial ligation followed by marginal vessel ligation appears to be the most satisfactory procedure for decreasing venous and lymphatic outflow and hopefully avoiding dissemination of cancer cells during the operation. This technic is now being used as a modification of the "no touch" technic for cancer of the colon.
D000818:Animals; D003097:Collateral Circulation; D003110:Colonic Neoplasms / Q000601:surgery*; D004285:Dogs; D008026:Ligation / Q000379:methods; D008196:Lymph / Q000502:physiology; D008638:Mesenteric Arteries / Q000503:physiopathology / Q000601:surgery*; D008642:Mesenteric Veins / Q000503:physiopathology / Q000601:surgery; D012039:Regional Blood Flow