title: Fine structural study of annulate lamellae complexes in human tumors.
abstract: Specific intracytoplasmic organelles, annulate lamellae and radial cisternae, have been studied in several human tumours. Annulate lamellae are observed in all cases of leiomyoma, leiomyosarcoma, rhabdomyosarcoma and malignant melanoma, whereas radial cisternae are only found in a case of leiomyosarcoma. Annulate lamellae are characterized by stacks of parallel arrayed long cisternae showing alternative arrangement of annuli and sacs. Some of these cisternae are connected directly with rough-surfaced endoplasmic reticulum and there is continuity with the lumen and membrane. Radial cisternae are mainly composed of two structures: numerous short cisternae, which are a variant of annulate lamellae, and numerous spherical particles derived from the cisternae. The cisternae are arranged parallel or radially around particles measuring up to 1100 A in diameter. These particles consisting of an amorphous high electron dense material without distinct limiting membrane are organized in groups and vary in number. There is no evidence of a direct relationship between these structures and viral infection.
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D007414:Intestinal Neoplasms / Q000648:ultrastructure; D007889:Leiomyoma / Q000648:ultrastructure; D007890:Leiomyosarcoma / Q000648:ultrastructure; D008545:Melanoma / Q000648:ultrastructure; D008854:Microscopy, Electron; D008875:Middle Aged; D009369:Neoplasms / Q000648:ultrastructure*; D009669:Nose Neoplasms / Q000648:ultrastructure; D009940:Organoids / Q000502:physiology / Q000648:ultrastructure*; D010534:Peritoneal Neoplasms / Q000648:ultrastructure; D012208:Rhabdomyosarcoma / Q000648:ultrastructure