Plasma levels of phenobarbital and phenytoin in epileptic outpatients.
In a group of 65 epileptic outpatients the reliability of intake of prescribed medication was evaluated according to two criteria. The following results were obtained: the number of patients with no or irregular intake of antiepileptic drugs in the whole group was 28%; the relationship between dose and observed plasma levels in patients reliable to intake could be verified; physicians were more often aware of unreliable intake by their patients than could be expected by chance.
D000293:Adolescent; D000328:Adult; D000553:Ambulatory Care; D002648:Child; D004305:Dose-Response Relationship, Drug; D004827:Epilepsy / Q000097:blood / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010634:Phenobarbital / Q000008:administration & dosage / Q000097:blood* / Q000627:therapeutic use; D010672:Phenytoin / Q000008:administration & dosage / Q000097:blood* / Q000627:therapeutic use
D010672:Phenytoin; D010634:Phenobarbital