[Pathogenetic concept of experimental mycoplasma arthritis].
Biochemical studies of rats with mycoplasma arthritis revealed new findings in pathogenesis and pathophysiology. Mycoplasma infection which resembles rheumatoid arthritis, leads to an inhibition of the DNA-repair. We were able to proof this enzyme--kinetically and autoradiographically. We also observed for the first time the occurrence of DNA-antibodies in this type of arthritis. It is possible that there is a relation between inhibition of DNA-repair and the occurrence of DNA-antibodies. Thus mycoplasma infection seems to influence DNA-metabolism. There are interesting parallels concerning DNA-antibodies and DNA-repair between experimental mycoplasma arthritis and human systemic lupus erythematosus and rheumatoid arthritis.
D000818:Animals; D000917:Antibody Formation; D001170:Arthritis, Infectious / Q000209:etiology* / Q000276:immunology; D001666:Binding Sites, Antibody; D004260:DNA Repair; D004269:DNA, Bacterial / Q000378:metabolism; D005260:Female; D009174:Mycoplasma / Q000378:metabolism; D009175:Mycoplasma Infections / Q000150:complications* / Q000276:immunology; D010587:Phagocytosis; D051381:Rats
D004269:DNA, Bacterial
Das pathogenetische Konzept der experimentellen Mykoplasma-Arthritis