[Experimental splenic artery ligation. Changes in hemodynamics and immunoreaction].
In 27 male rabbits the splenic artery was ligated. During the procedure and 10-14 days postoperatively, orthostatic regulation using a tilting table, the hemogram (RBC + WBC), and concentration of immunoglobulins (IgG and IgM) were measured. The arterial and venous blood pressure (CVP and portal vein) were only slightly increased whereas there was a marked (up to 40%) increase in the area of the mesenteric veins compared with the preoperative values. The orthostatic tolerance by 90degrees was uniformly diminished. No changes were seen in the hemogram nor in the immunoglobulins. Macroscopically and microscopically a fibrotic transformation of the spleen was seen.
D000818:Animals; D001794:Blood Pressure; D006439:Hemodynamics; D007109:Immunity; D007070:Immunoglobulin A / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008026:Ligation; D008297:Male; D008642:Mesenteric Veins; D011817:Rabbits; D013154:Spleen / Q000473:pathology / Q000502:physiology*; D013157:Splenic Artery / Q000601:surgery*; D014690:Venous Pressure
D007070:Immunoglobulin A; D007075:Immunoglobulin M
Experimentelle Milzarterienligatur. Beitrag zur Anderung der Hämodynamik und Immunreaktion