Resolution of lipid-containing atherosclerotic lesions induced by injury.
In previous experiments, injury-induced atherosclerosis has been shown to be associated with the development of fatty streaks. The findings suggested that fatty streaks might represent a stage in healing of intimal injury evolving to fibrous plaques, free of lipid. The present experiment was designed to study the incidence and evolution of these lesions during a 2-week period of lesion retrogression following removal of a catheter placed in the aorta for 1 week. The findings indicate that as fat-containing lesions, either of the thromboatherosclerotic or fatty streak varieties, decreased, the amount of nonlipid-containing fibrous lesions increased.
D000818:Animals; D001011:Aorta / Q000293:injuries / Q000473:pathology; D001158:Arteries / Q000293:injuries*; D001161:Arteriosclerosis / Q000209:etiology* / Q000473:pathology; D002404:Catheterization; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D008297:Male; D011817:Rabbits
D002784:Cholesterol