Pigmented hyperplasia of epidermis following feeding of L-dopa to elderly rats.
In view of clinical data supporting a casual relationship between long-term L-dopa administration and recurrence of melanoma, long-term L-dopa administration to aged rats was performed to investigate its effect on the incidence of malignant melanoma. Of the treated animals, 11% showed local pigmented epidermal hyperplasia, compared with 0.5% of the control animals, but the number of expected melanomas was not increased by L-dopa treatment.
D000367:Age Factors; D000818:Animals; D006801:Humans; D006965:Hyperplasia; D007980:Levodopa / Q000009:adverse effects* / Q000494:pharmacology; D008297:Male; D008543:Melanins / Q000096:biosynthesis; D008545:Melanoma / Q000139:chemically induced* / Q000473:pathology; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology; D010858:Pigmentation / Q000187:drug effects; D011230:Precancerous Conditions / Q000139:chemically induced* / Q000473:pathology; D051381:Rats; D011914:Rats, Inbred BN; D012008:Recurrence; D012867:Skin / Q000187:drug effects*; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000473:pathology
D008543:Melanins; D007980:Levodopa