title: Effect of estracyt on the rat prostate.
abstract: Two types of experiments were performed to elucidate the estrogenic effect of estracyt on the ventral and immature rats that had received injections of testosterone; then changes in weight of accessory rats and changes in weight of the total body, the ventral and the dorsolateral prostates, and adrenal gland, and changes in activities of testosterone 5alpha-reductase, alkaline phosphatase, and arginase of both lobes of the prostates were examined. In the second experiment, estracyt was injected into castrates rats and immature rats that had received injections of testosterone; then changes in weight of accessory sex organs were determined. Because similar changes were induced by treatment of animals with estradiol-17beta, it was concluded that the effect of estracyt on the prostates was most likely attributable to the estrogenic effect of the drug.
mesh_terms: D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase / Q000378:metabolism; D000311:Adrenal Glands / Q000033:anatomy & histology / Q000187:drug effects; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001119:Arginase / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D002369:Castration; D004958:Estradiol / Q000494:pharmacology; D004961:Estramustine / Q000494:pharmacology*; D008297:Male; D009588:Nitrogen Mustard Compounds / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D011467:Prostate / Q000187:drug effects* / Q000201:enzymology; D051381:Rats; D013737:Testis / Q000033:anatomy & histology
chemical_list: D009588:Nitrogen Mustard Compounds; D004961:Estramustine; D004958:Estradiol; D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase; D000469:Alkaline Phosphatase; D001119:Arginase