Bactericidal synergistic effect due to chloramphenicol-induced inhibition of staphyloccal penicillinase.
A synergistic bactericidal effect of chloramphenicol and penicillin-G was observed with 17 out of 20 beta-lactamase producing strains of Staphylococcus aureus. The synergism was due to chloramphenicol-induced inhibition of beta-lactamase production. With seven of the strains the synergistic effect was operative only with subinhibitory concentrations of chloramphenicol, while higher concentrations produced antagonism.
D002701:Chloramphenicol / Q000494:pharmacology*; D004357:Drug Synergism; D008826:Microbial Sensitivity Tests; D010400:Penicillin G / Q000494:pharmacology*; D010403:Penicillin Resistance; D010405:Penicillinase / Q000378:metabolism*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000201:enzymology; D013997:Time Factors
D002701:Chloramphenicol; D010405:Penicillinase; D010400:Penicillin G