Plasma noradrenaline concentrations in experimental renovascular hypertension in the rat.
1. Plasma noradrenaline concentrations and dopamine beta-hydroxylase activity have been measured at various stages in the development of hypertension in the one-kidney Goldblatt rat (unilateral renal arterial constriction and contralateral nephrectomy). 2. Although plasma noradrenaline concentrations were significantly elevated from control values at 7, 14 and 28 days, plasma dopamine beta-hydroxylase activity was not significantly different from control values except at 24 h. 3. These findings suggest that peripheral sympathetic activity is increased in the one-kidney Goldblatt model of experimental hypertension but that plasma dopamine beta-hydroxylase activity is poor index of this increase. 4. Both the rise in blood pressure and the rise in plasma noradrenaline concentrations were prevented by pretreatment with intracisternal 6-hydroxydopamine, suggesting that the increased sympathetic activity is at least in part centrally mediated.
D000818:Animals; D004299:Dopamine beta-Hydroxylase / Q000097:blood; D006977:Hypertension, Renal / Q000097:blood* / Q000201:enzymology; D008297:Male; D009638:Norepinephrine / Q000097:blood*; D051381:Rats; D013564:Sympathetic Nervous System / Q000503:physiopathology; D013997:Time Factors
D004299:Dopamine beta-Hydroxylase; D009638:Norepinephrine