title: Prostaglandins and congeners XIII (1). The synthesis of dl-erythro-16-methoxyprostaglandins.
abstract: dl-Erythro-16-methoxy-PGE2, PGA2, PGF2alpha, 11-deoxy PGE1, and 11-deoxy PGF1alpha have been prepared via the cuprate conjugate addition procedure. These congeners are less potent than the parent prostaglandins as stimulators of isolated gerbil colon contractions and as bronchodilators in the guinea pig Konzett assay.
mesh_terms: D000818:Animals; D001980:Bronchi / Q000187:drug effects; D003106:Colon / Q000187:drug effects; D005849:Gerbillinae; D006168:Guinea Pigs; D008968:Molecular Conformation; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D011453:Prostaglandins / Q000138:chemical synthesis*; D011454:Prostaglandins A / Q000138:chemical synthesis / Q000494:pharmacology; D011458:Prostaglandins E / Q000138:chemical synthesis / Q000494:pharmacology; D011460:Prostaglandins F / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D011453:Prostaglandins; D011454:Prostaglandins A; D011458:Prostaglandins E; D011460:Prostaglandins F