Progesterone-induced DNA polymerase activity in full-grown oocytes of Xenopus laevis (1).
DNA polymerase activity increases in full-grown oocytes of Xenopus laevis during in vitro progesterone-induced maturation. This increase is inhibited by cycloheximide. The presence of the oocyte's nucleus (germinal vesicle) seems essential for the induction of this increase: in previously enucleated oocytes, the level of DNA polymerase activity does not change during progesterone treatment. Furthermore, a new form of DNA polymerase is detectable by DEAE chromatography in in vitro matured oocytes.
D000818:Animals; D003513:Cycloheximide / Q000494:pharmacology; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism*; D005260:Female; D007527:Isoenzymes / Q000378:metabolism; D009865:Oocytes / Q000187:drug effects / Q000201:enzymology*; D010063:Ovum / Q000201:enzymology*; D011374:Progesterone / Q000494:pharmacology*; D013997:Time Factors; D014981:Xenopus / Q000378:metabolism*
D007527:Isoenzymes; D011374:Progesterone; D003513:Cycloheximide; D004259:DNA-Directed DNA Polymerase