title: The metabolic basis of alcohol's toxicity.
abstract: The mechanisms by which excess alcohol directly damages the liver cells have been elucidated by studies in the baboon, which have shown that inability of the liver's enzyme systems to cope with hydrogen and fat overloads is far more significant in the progression to cirrhosis than any indirect effects of malnutrition. With the appearance of mitochondrial deformation, the process may have reached the stage of irreversibility.
mesh_terms: D000437:Alcoholism / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D004721:Endoplasmic Reticulum / Q000187:drug effects; D000431:Ethanol / Q000378:metabolism*; D005234:Fatty Liver / Q000139:chemically induced; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D008930:Mitochondria, Liver / Q000187:drug effects; D010215:Papio
chemical_list: D000431:Ethanol