[Lincomycin concentration in human serum and pulmonary tissue].
Lincomycin levels in the blood serum and lung tissue were determined in 17 patients after surgical operations because of the lung diseases, the drug being administered in a dose of 500 mg. In 45 to 330 minutes after administration of the antibiotic its concentration in the blood serum and lung tissue was 4.6 +/- 10 lambda/ml(average 7.7 lambda/ml) and 1.4-8 lambda/gm (average 4.4 lambda/gm) respectively. The lincomycin level in the lung tissue amounted to 61 per cent of that in the blood setum. The concentration of lincomycin the lung tissue was several times higher than the minimum level necessary for inhibition of the strains included in the antibiotic antibacterial spectrum. Therefore, lincomycin is an important drug in the treatment of infections of the respiratory tract.
D000328:Adult; D000368:Aged; D001702:Biopharmaceutics; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008034:Lincomycin / Q000008:administration & dosage / Q000032:analysis*; D008168:Lung / Q000032:analysis*; D008171:Lung Diseases / Q000188:drug therapy; D008297:Male; D008875:Middle Aged
D008034:Lincomycin
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