Clinical aspects of the polycystic ovary syndrome.
One hundred and one patients with polycystic ovary syndrome (PCO) were treated during an 11-year interval. Sixty-seven cases were classified as typical PCO with enlarged ovaries of probable ovarian origin (Type I) and 34 as atypical PCO of probable adrenal origin (Type II). Fifty-five patients were treated for anovulatory infertility with clomiphene citrate or other endocrine therapy as indicated. There was a 91% ovulatory response and 51% conception rate from therapy in cases of Type I PCO. In Type II PCO, adrenal suppressive therapy resulted in a 55% ovulatory response. Our data support the concept that anovulation of ovarian origin as seen in PCO Type I responds to clomiphene therapy, while anovulation secondary to adrenal hyperandrogenization should be treated by adrenal suppressive therapy.
D015068:17-Ketosteroids / Q000652:urine; D000308:Adrenocortical Hyperfunction / Q000503:physiopathology; D002996:Clomiphene / Q000627:therapeutic use; D005260:Female; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000145:classification / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology* / Q000652:urine
D015068:17-Ketosteroids; D002996:Clomiphene