[Role of the kallikrein-kinin system of the kidneys in sodium and water transport and changes in it under the influence of indomethacin].
A direct relationship between the level of the kallikrein activity in the urine, and diuresis, natriuresis and the capacity of the kidneys to concentrate the urine in healthy rats was revealed. Low doses of indometacin (2 mg/kg, for 5 days) increased the kallikrein activity in the urine four-fold, with a simultaneous rise of diuresis; high doses (5 mg/kg, for 5 days) cut the kallikrein activity in the urine by half and decreased natriuresis three-fold. At the same time there was also a decreased capacity to concentrate the urine. Thus, indometacin changed not only the prostaglandine synthesis, but also that of kallikrein, this influencing the functional state of the kidney.
D000818:Animals; D004231:Diuresis / Q000187:drug effects*; D007213:Indomethacin / Q000494:pharmacology*; D007610:Kallikreins / Q000652:urine*; D007671:Kidney Concentrating Ability / Q000187:drug effects*; D008297:Male; D009318:Natriuresis / Q000187:drug effects*; D051381:Rats
D007610:Kallikreins; D007213:Indomethacin
Rol' kallikrein-kininovoĭ sistemy pochek v transporte natriia i vody i izmenenie ee pod vliianiem indometatsina