title: Lactate in fast and slow twitch skeletal muscle fibres of man during isometric contraction.
abstract: Concentration of lactate in fast and slow twitch fibres, respectively, were determined in m. quadriceps femoris after sustained contractions at 25%, 50%, and 75% of maximal voluntary isometric contraction (MVC) until exhaustion as well as after interrupted exercises at 25% and 50% MVC. Maximal lactate concentrations were only found at 50% of MVC performed to exhaustion. Lactate concentration was higher in slow twitch (ST) fibres at 50% MVC compared to in ST fibres at 25% MVC, and higher in fast twitch (FT) fibres at 50% MVC compared to in FT fibres at 75% MVC. After short time isometric exercise (i.e. 75% to exhaustion and 50% and 25% performed for the same period of time as 75% MVC) lactate concentration, expressed as lactate ratio (lactate concentration in FT fibres/lactate concentration in ST fibres) was found to be positively correlated to percent FT fibres (r=0.89). Lactate ratio ranged 0.5-2.0, i.e. at onset of isometric exercise, lactate concentration increase was faster in ST fibres in the muscle rich in ST fibres and faster in FT fibres when the muscle wasrich in FT fibres.
mesh_terms: D000367:Age Factors; D001827:Body Height; D001835:Body Weight; D005269:Femur; D006801:Humans; D007773:Lactates / Q000378:metabolism*; D008297:Male; D009119:Muscle Contraction; D009132:Muscles / Q000378:metabolism*; D005082:Physical Exertion
chemical_list: D007773:Lactates