title: The use of nicotine gum during cessation of smoking.
abstract: The authors present three case studies which suggest that smoking withdrawal symptoms in certain individuals may be due to removal of nicotine per se, implying that smokers may develop a true physical dependence on cigarettes. Nicotine replacement by use of an experimental chewing gum containing nicotine in various dosages successfully prevented or alleviated the abstinence symptoms of the subjects studied.
mesh_terms: D002638:Chewing Gum; D004341:Drug Evaluation; D006801:Humans; D008297:Male; D009538:Nicotine / Q000008:administration & dosage* / Q000627:therapeutic use; D010919:Placebos; D000074606:Smoking Prevention; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy*
chemical_list: D002638:Chewing Gum; D010919:Placebos; D009538:Nicotine