Metabolism of intravenous adenine in the pig.
1. Adenine administered either parenterally or orally is less toxic to the pig than to other species; doses of 100 mg/kg are rapidly catabolised and excreted largely as soluble purine end-products in the urine. 2. The low toxicity is explained by the excretion of less than 1% of the dose as 2,8-dihydroxyadenine. 3. These results suggest that adenine dosages which give rise to kidney damage must be above a threshold-like level which varies in the different mammalian species, and is higher in the pig than in the rat, dog, rabbit or man.
D000225:Adenine / Q000008:administration & dosage / Q000378:metabolism* / Q000633:toxicity; D000284:Administration, Oral; D000481:Allantoin / Q000652:urine; D000493:Allopurinol / Q000494:pharmacology; D000818:Animals; D007042:Hypoxanthines / Q000652:urine; D007275:Injections, Intravenous; D013045:Species Specificity; D013552:Swine; D014527:Uric Acid / Q000652:urine; D014970:Xanthines / Q000652:urine
D007042:Hypoxanthines; D014970:Xanthines; D014527:Uric Acid; D000481:Allantoin; D000493:Allopurinol; D000225:Adenine