Stimulation of testicular protein synthesis in vivo by gonadotrophins and growth hormone in hypophysectomized adult mice.
The effects of FSH, HCG, GH and testosterone on testicular protein synthesis were investigated in hypophysectomized adult mice by measuring the incorporation of tritiated lysine into acid-precipitable material. The incorporation per mg protein was increased by FSH, HCG and GH but decreased by testosterone. The maximum effect of FSH occurred at between 8 and 14 h after administration of the hormone, much later than found in vitro for the rat.
D000818:Animals; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D005640:Follicle Stimulating Hormone / Q000494:pharmacology; D006062:Gonadotropins / Q000494:pharmacology*; D013006:Growth Hormone / Q000494:pharmacology*; D007016:Hypophysectomy; D008239:Lysine / Q000378:metabolism; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D014176:Protein Biosynthesis; D013737:Testis / Q000378:metabolism*; D013739:Testosterone / Q000494:pharmacology; D013997:Time Factors
D006063:Chorionic Gonadotropin; D006062:Gonadotropins; D013739:Testosterone; D005640:Follicle Stimulating Hormone; D013006:Growth Hormone; D008239:Lysine