The effect of intraarterial administered aminophylline on cerebral hemodynamics in man.
The dose-effect relationship of intracarotid administered aminophylline on cerebral hemodynamics in man was investigated by means of an intraarterial 133Xenon injection method. A dose dependent vasoconstriction was clearly demonstrated. The maximum efficacy expressed as measured decreased in global cerebral blood flow was 21.9 per cent +/- 6.2 SD. Administration of as little as 1 mg aminophylline produced a measureable vasoconstriction.
D000368:Aged; D000628:Aminophylline / Q000008:administration & dosage* / Q000494:pharmacology; D002339:Carotid Arteries; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D002561:Cerebrovascular Disorders / Q000188:drug therapy* / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007269:Injections, Intra-Arterial; D008875:Middle Aged
D000628:Aminophylline