A radiographic and histologic study of fracture healing in osteopetrotic rats.
Repair of tibial fractures in osteopetrotic rats was delayed in comparison to that of normal littermates, due to reduced remodeling. Reduced bone resorption, known to be the cause of the disease in this mutation, is expressed in both skeletal development and fracture repair. The possible implications for human juvenile osteopetrosis are discussed.
D000818:Animals; D050723:Fractures, Bone / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D010022:Osteopetrosis / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D011859:Radiography; D051381:Rats; D013978:Tibial Fractures / Q000503:physiopathology; D014945:Wound Healing