title: [Excretion of alanine aminopeptidase in the urine after administration of lysosomotrophic substances in patients with latent or florid pyelonephritis].
abstract: It is described a test for the presence of diffuse nephropathies which is based on the fact that after application 20 ml of the renal diatrizoate X-ray contrast medium Visotrast or of 500 ml of a 10% mannitol solution in patients with preexisting renal diseases appear reversible, diagnostically relevant increases of the alanine aminopeptidase excretion with the urine. In persons with healthy kidneys the excretion of enzymes changes insignificantly. The increased excretion of alanine aminopeptidase is also observed in patients with latent pyelonephritis and is traced back to the increased formation of an osmotic nephropathy in patients with preexisting nephropathies.
mesh_terms: D000409:Alanine; D000626:Aminopeptidases / Q000652:urine*; D001437:Bacteriuria / Q000201:enzymology; D002908:Chronic Disease; D003973:Diatrizoate / Q000494:pharmacology*; D006801:Humans; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000652:urine; D008353:Mannitol / Q000008:administration & dosage; D011704:Pyelonephritis / Q000201:enzymology* / Q000652:urine
chemical_list: D007527:Isoenzymes; D003973:Diatrizoate; D008353:Mannitol; D007770:L-Lactate Dehydrogenase; D000626:Aminopeptidases; D000409:Alanine
vernacular_title: Alaninaminopeptidaseausscheidung im Harn nach Gabe lysosomotroper Substanzen bei Patienten mit latenter und florider Pyelonephritis