title: Histopathology of preneoplastic and neoplastic lesions of the esophagus in BUF rats ingesting diethylnitrosamine.
abstract: Carcinomas developed in the mucosa of the esophagus in BUF strain rats ingesting diethylnitrosamine in the diet. The stages of hyperplasia, hyperplastic nodules, small carcinomas, and large, well-developed carcinomas were observed. Carcinomas, which were well differentiated, poorly differentiated, or undifferentiated, invaded the adjacent tissue but did not metastasize.
mesh_terms: D000818:Animals; D002277:Carcinoma / Q000473:pathology; D002280:Basal Cell Carcinoma / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D004052:Diethylnitrosamine; D004938:Esophageal Neoplasms / Q000139:chemically induced / Q000473:pathology*; D005260:Female; D006965:Hyperplasia / Q000139:chemically induced; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology; D010212:Papilloma / Q000473:pathology; D011230:Precancerous Conditions / Q000139:chemically induced / Q000473:pathology*; D051381:Rats; D011915:Rats, Inbred BUF
chemical_list: D004052:Diethylnitrosamine