title: The influence of age on the development of hypertriglyceridaemia and hypercholesterolaemia in genetically diabetic mice.
abstract: The effect of spontaneous diabetes on plasma lipids during the natural course of the disease was studied in genetically diabetic mice (C57BL/KsJ-db/db). Hyperlipidaemia developed uniformly in all mice studied and was found to be a characteristic part of the diabetic syndrome, as compared to normal littermates. The hyperlipidaemia was characterized by a marked rise in plasma triglyceride levels with age and severity of the disease increaing from 120+/-6 mg/dl at 5 weeks of age to 400+/-91 mg/dl at 19 weeks of age. In addition, db/db mice were observed to be hypercholesterolaemic as compared to age-matched normal littermates, The plasma cholesterol levels of diabetic mice were elevated early in the disease, as compared to control mice (200+/-6 vs. 130+/-7 mg/dl, respectively), and the mean level remained elevated throughout the period of observation.
mesh_terms: D000375:Aging; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight; D002784:Cholesterol / Q000097:blood*; D003920:Diabetes Mellitus / Q000097:blood* / Q000235:genetics; D006949:Hyperlipidemias / Q000209:etiology; D007328:Insulin / Q000097:blood; D051379:Mice; D008810:Mice, Inbred C57BL; D014280:Triglycerides / Q000097:blood*
chemical_list: D001786:Blood Glucose; D007328:Insulin; D014280:Triglycerides; D002784:Cholesterol