Dephenylation of N-phenyl-2-naphthylamine in dogs and its possible oncogenic implications.
N-Dephenylation of N-phenyl-2-naphthylamine (PBNA) is strictly limited in dogs, and a 5 mg/kg dose gives 0-10 microng of urinary 2-naphthylamine (BNA), which does not appear to undergo further metabolism. Neither 2-naphthylhydroxylamine (BNHA) nor 2-amino-1-naphthylsulphate were detected in the urine of treated animals. Urinary output of BNA varies markedly between dogs, and at different times in the same animal. The extent of PBNA N-dephenylation is unaltered by chronic administration. Calculations based on Druckery and Küpfmüller's equation (1948) and present data indicate that, for dogs to form BNA tumours through exposure to a relatively high dose-level of PBNA, the period of daily dosing would occupy, or even exceed, the normal life-span. The carcinogenic risk of PBNA to human subjects is discussed.
D015081:2-Naphthylamine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000652:urine; D000814:Aniline Compounds / Q000378:metabolism / Q000652:urine; D000818:Animals; D004285:Dogs; D005260:Female; D008297:Male; D009281:Naphthalenes / Q000378:metabolism*; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D013997:Time Factors
D000814:Aniline Compounds; D009281:Naphthalenes; C011948:neozone; D015081:2-Naphthylamine