The effect of ritodrine on PgE levels in pregnant rabbit vena cava blood.
A chronic model was utilized in the rabbit to determine the effect of ritodrine hydrochloride infusions on pregnancy. Infusions were carried out for 6 hours in the unanesthetized, conscious animal between the 25 to 27 day of pregnancy. Pre and post infusion blood samples were drawn from a catheter lying at the lower inferior vena cava and analyzed for prostaglandin E and F, and progesterone. As compared to a control animal, there was a significant fall in prostaglandin E after 6 hour infusion of drug, but no change in prostaglandin F or progesterone was observed.
D000818:Animals; D005260:Female; D008954:Models, Biological; D011247:Pregnancy; D011270:Pregnancy, Animal; D011374:Progesterone / Q000097:blood; D011412:Propanolamines / Q000494:pharmacology*; D011458:Prostaglandins E / Q000097:blood*; D011460:Prostaglandins F / Q000097:blood; D011817:Rabbits; D012312:Ritodrine / Q000494:pharmacology*; D014682:Vena Cava, Inferior
D011412:Propanolamines; D011458:Prostaglandins E; D011460:Prostaglandins F; D011374:Progesterone; D012312:Ritodrine