Amphotericin B susceptibility testing of yeasts with a bactec radiometric system.
The effect of amphotericin B on CO(2) production was studied using a Bactec 225. A radiometric procedure for yeast susceptibility testing that requires 3 h of incubation was developed. A total of 48 yeast isolates was tested in this system and the results were correlated to tube dilution studies. The drug concentration causing at least a 44% decrease in CO(2) production correlated to the tube dilution minimal inhibitory concentration in 85% of isolates tested and was within one tube dilution of the minimal inhibitory concentration in over 95% of yeasts tested.
D000666:Amphotericin B / Q000494:pharmacology*; D002245:Carbon Dioxide / Q000378:metabolism; D008722:Methods; D008826:Microbial Sensitivity Tests / Q000295:instrumentation; D013997:Time Factors; D015003:Yeasts / Q000187:drug effects* / Q000378:metabolism
D002245:Carbon Dioxide; D000666:Amphotericin B