title: Adaptive increase of respiratory enzymes in the mitochondria from cirrhotic livers of patients and rats, and its relationship to glucose tolerance.
abstract: Oxidative phosphorylation and respiratory enzyme concentrations of liver mitochondria and glucose tolerance were studied in 12 cirrhotic patients and CCl4-induced cirrhotic rats. The cirrhotic patients with normal or higher concentrations of cytochrome a(+a3) showed parabolic glucose tolerance test (GTT) patterns having return of blood glucose level somewhat toward normal within two hours and tolerated major operations well, while three patients with cytochrome a(+a3) concentrations less than 60 per cent of normal (0.81 +/- 0.02 (mean +/- SEM) X 10(-10) moles/mg protein) could not tolerate even minor operations. In CCl4-induced cirrhotic rats, cytochrome a(+a3) concentrations varied from 1.5 to 3.0 X 10(-10) moles/mg protein as compared with 1.8 +/- 0.1 of controls. In mitochondria with normal or higher concentrations of cytochrome a(+a3), the oxidative and phosphorylative activities per unit of cytochrome a(+a3) were negatively correlated with cytochrome a(+a3) concentrations. These rats tolerated partial hepatectomy well. However, in cirrhotic rats with subnormal cytochrome a(+a3) concentrations there was a high mortality following  hepatectomy. The former showed parabolic GTT patterns, while the latter showed nonparabolic GTT patterns.
mesh_terms: D000328:Adult; D000818:Animals; D003580:Cytochromes / Q000032:analysis*; D005260:Female; D005951:Glucose Tolerance Test; D006498:Hepatectomy / Q000401:mortality; D006801:Humans; D008099:Liver / Q000648:ultrastructure; D008103:Liver Cirrhosis / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D008106:Liver Cirrhosis, Experimental / Q000378:metabolism; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D008930:Mitochondria, Liver / Q000378:metabolism*; D010085:Oxidative Phosphorylation; D051381:Rats
chemical_list: D003580:Cytochromes