Long-term management of abetalipoproteinaemia. Possible role for vitamin E.
Eight patients with abetalipoproteinaemia have been followed for 3-4 to 15-8 years. Management included dietary fat restriction and supplements of the fat-solublevitamins A, E, and K. In the 3 oldest patients serial studies of retinal and neurological function suggest that treatment with large doses of oral vitamin E may have delayed the development or progression of the neurological and retinal lesions.
D000012:Abetalipoproteinemia / Q000150:complications / Q000188:drug therapy*; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006128:Growth; D006801:Humans; D007223:Infant; D008297:Male; D009461:Neurologic Manifestations / Q000209:etiology; D012162:Retinal Degeneration / Q000209:etiology; D014801:Vitamin A / Q000627:therapeutic use; D014810:Vitamin E / Q000627:therapeutic use*
D014801:Vitamin A; D014810:Vitamin E