GI drug absorption in rats exposed to cobalt-60 gamma-radiation I: Extent of absorption.
The extent of absorption of sulfanilamide, bretylium tosylate, sulfisoxazole acetyl, and riboflavin was determined in rats exposed to 850 rad of cobalt-60 gamma-radiation of sham irradiated. The drug were administered orally at 1 or 5 days postirradiation, and the amount of drug excreted in the urine was used as the measure of absorption. Following intravenous drug administration, there was no difference between irradiated and control animals in the amount of drug excreted in the urine. At 1 day postirradiation, the absorption of sulfanilamide and bretylium was not affected by radiation; the absorption of sulfisoxazole acetyl and riboflavin was increased. The fraction of sulfanilamide excreted in the urine as N4-conjugate was increased at 1 day postirradiation. At 5 days postirradiation, there was no detectable difference between irradiated and control animals in the extent of drug absorption. The effects of radiation on the extent of absorption of orally administered drugs were most pronounced immediately following irradiation. Irradiation apparently does not affect the absorption of drugs that are normally well absorbed or poorly absorbed due to slow transport across the GI mucosa. Following irradiation, there may be an increase in the extent of absorption of drugs that are poorly absorbed due to low aqueous solubility or that are absorbed by a saturable transport mechanism.
D000818:Animals; D001682:Biological Availability; D001950:Bretylium Tosylate / Q000652:urine; D003037:Cobalt Radioisotopes; D004435:Eating; D005720:Gamma Rays; D007408:Intestinal Absorption / Q000528:radiation effects*; D008297:Male; D051381:Rats; D012256:Riboflavin / Q000652:urine; D013424:Sulfanilamides / Q000652:urine; D013444:Sulfisoxazole / Q000652:urine; D013997:Time Factors
D003037:Cobalt Radioisotopes; D013424:Sulfanilamides; D013444:Sulfisoxazole; D001950:Bretylium Tosylate; D012256:Riboflavin