Reduced warfarin binding of albumin variants.
Binding studies of albumins A/A and A/Me from human plasma and isolated albumin revealed small, but statistically significant, reductions in warfarin binding of albumin A/Me compared to albumin A/A. Such differences in binding in vitro could result in altered pharmacological responses to warfarin administered to individuals possessing albumin A/Me. To determine if clinically significant differences in warfarin distribution exist, observations should be made in vivo on patients of different albumin phenotype who are receiving warfarin therapeutically.
D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D066298:In Vitro Techniques; D007198:Indians, North American; D007700:Kinetics; D011485:Protein Binding; D012709:Serum Albumin / Q000378:metabolism*; D014859:Warfarin / Q000097:blood*
D012709:Serum Albumin; D014859:Warfarin