Effect of a coat color locus on kidney lysosomal glycosidases in the house mouse.
Activities of three lysosomal glycosidases, beta-galactosidase, beta-glucuronidase, and N-acetyl-beta-hexosaminidase, have been shown to differ in bf/bf and bf/+ mice. Thus bf/bf mice usually have much higher activities of these enzymes in their kidney cells than bf/+ animals. There seem, however, to be some exceptions to this general pattern, especially for galactosidase of females from the C57BL/6J strain. A likely interpretation of the difference is that the bf locus has pleiotropic effects. An alternative explanation, less likely, is that a gene closely linked to bf is involved. There is also a differential response to dihydrotestosterone in different groups of mice reflected in activity changes of the three enzymes.
D000818:Animals; D005260:Female; D005696:Galactosidases / Q000378:metabolism*; D005796:Genes; D005966:Glucuronidase / Q000378:metabolism*; D006200:Hair Color; D006579:Heterozygote; D006596:Hexosaminidases / Q000378:metabolism*; D006720:Homozygote; D007668:Kidney / Q000201:enzymology*; D008247:Lysosomes / Q000201:enzymology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA
D005696:Galactosidases; D006596:Hexosaminidases; D005966:Glucuronidase