title: RBC transfusions in paroxysmal nocturnal hemoglobinuria.
abstract: Frozen-thawed, deglycerolized RBCs can be substituted for saline-washed RBCs for transfusion of patients with paroxysmal nocturnal hemoglobinuria (PNH). The effect of transfusion is to decrease bone marrow production of RBCS, which results in a decreased percentage of complement-sensitive erythrocytes. In the presence of small numbers of complement-sensitive erythrocytes, major vascular surgery can be performed without hemolytic problems. This study suggests that the percentage of complement-sensitive RBCs, as well as the complement sensitivity of these cells, influence the severity of hemolysis in persons with PNH.
mesh_terms: D000937:Antigen-Antibody Reactions; D001803:Blood Transfusion; D003165:Complement System Proteins; D004910:Erythrocyte Membrane / Q000276:immunology; D017707:Erythrocyte Transfusion; D004920:Erythropoiesis; D006457:Hemoglobinuria, Paroxysmal / Q000097:blood / Q000150:complications / Q000628:therapy*; D006461:Hemolysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D014656:Vascular Surgical Procedures
chemical_list: D003165:Complement System Proteins