Outcome at ages 1, 3, and 5 years of children born to diabetic women.
A prospective study of infants born to women with diabetes mellitus is reported. The children were examined at birth and followed at 1, 3, and 5 years of age. Medical and psychological information was obtained through follow-up examinations. Intrauterine growth was atypical and there was an increase in neonatal problems and congenital malformations. There was an increased incidence of intellectual delay at 3 and 5 years of age. The presence of acetone in the urine during pregnancy had a significant, adverse effect on intellectual status of the offspring at 5 years of age. Birth weight was negatively related to intellectual status at both 3 and 5 years of age.
D000096:Acetone / Q000652:urine; D000367:Age Factors; D002675:Child, Preschool; D000013:Congenital Abnormalities / Q000453:epidemiology / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000453:epidemiology / Q000209:etiology; D007236:Infant, Small for Gestational Age; D008607:Intellectual Disability / Q000453:epidemiology / Q000209:etiology; D007484:Iowa; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000150:complications; D011446:Prospective Studies
D000096:Acetone