Co-trimoxazole in chronic renal failure--a controlled experiment in Wistar rats.
Co-trimoxazole failed to cause a deterioration in renal function, as measured by pre- and posttreatment plasma urea levels, in groups of Wistar rats with either normal renal function or surgically induced chronic renal failure. In addition tubular necrosis was not produced. Co-trimoxazole does not appear to be extremely toxic to the Wistar rat kidney.
D000818:Animals; D004338:Drug Combinations; D007668:Kidney / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D051381:Rats; D013444:Sulfisoxazole / Q000009:adverse effects*; D014295:Trimethoprim / Q000009:adverse effects*; D014508:Urea / Q000097:blood
D004338:Drug Combinations; D013444:Sulfisoxazole; D014508:Urea; D014295:Trimethoprim