[Dimeric mechanism of the work of nigericin in bilayer lipid membranes].
The electric properties of the bilayer lethitin membranes have been studied in the presense of the antibiotic nigericin. When the antibiotic concentration is about 10(-6) M the condactivity of the BLM is increased upto 10(-7) ohm-1cm-2. The potassium ion concentration gradient gives rise to a transmembrane potential of the order of 40 mV per 10--fold concentration gradient with the side of the higher potassium concentration negative. The transmembrane potential produced by the hydrogen ion  gradient is a function of the potassium ion concentration which is equal on both sides of the membrane. In order to account for the experimental results obtained, a theoretical approach has been developed based on the assumption that charge is transported across the membrane by nigericin dimers.
D000900:Anti-Bacterial Agents; D055598:Chemical Phenomena; D002621:Chemistry; D004553:Electric Conductivity; D008433:Mathematics; D008567:Membranes, Artificial; D009550:Nigericin; D010713:Phosphatidylcholines; D011188:Potassium; D011199:Potentiometry
D000900:Anti-Bacterial Agents; D008567:Membranes, Artificial; D010713:Phosphatidylcholines; D009550:Nigericin; D011188:Potassium
Dimernyĭ mekhanizm raboty nigeritsina na bisloĭnykh lipidnykh membranakh