Effects of ibotenic acid, quisqualic acid and their relatives on the excitability of an identifiable giant neurone of an African giant snail (Achatina fulica Férussac).
An identifiable giant neurone, PON (periodically oscillating neurone), of Achatina fulica Ferussac, inhibited by erythro-beta-hydroxy-L-glutamic acid, was also inhibited by 2 relatives of beta-hydroxy glutamic acid, ibotenic acid and quisqualic acid. These substances similarly showed the effect on the neurone even in the chloride-free medium.
D000409:Alanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D005971:Glutamates / Q000494:pharmacology*; D007051:Ibotenic Acid / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D010069:Oxadiazoles / Q000494:pharmacology*; D010080:Oxazoles / Q000494:pharmacology*; D012908:Snails / Q000502:physiology*; D013329:Structure-Activity Relationship
D005971:Glutamates; D010069:Oxadiazoles; D010080:Oxazoles; D007051:Ibotenic Acid; D000409:Alanine