Symmetry in prostaglandins.
Observations of the agonist activity of prostaglandins on the guinea-pig ileum are analysed. The structure-activity relationships are interpreted in relation to the approximate diad axis of symmetry in the molecules. It is suggested that some receptors for prostaglandins may have a perfect diad axis of symmetry between identical protein subunits.
D000495:Allosteric Site; D000818:Animals; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D008968:Molecular Conformation; D010100:Oxygen; D011453:Prostaglandins / Q000032:analysis / Q000494:pharmacology; D011458:Prostaglandins E / Q000032:analysis; D011460:Prostaglandins F / Q000032:analysis
D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; D010100:Oxygen