title: Formation of oxalate in pyridoxine or thiamin deficient rats during intravenous xylitol infusions.
abstract: Glucose, fructose, sorbitol and xylitol were assessed as precursors of oxalate in normal rats and rats deficient in thiamin or vitamin B-6. Urinary excretions of oxalate, glyoxylate and glycine were increased significantly in vitamin B-6 deficient rats infused with xylitol when compared with all other groups. Using [U-14C]xylitol, oxalate was shown to be derived directly from this polyalcohol in vitamin B-6 deficient rats. These results suggest that vitamin B-6 deficiency may be a factor contributing to oxalate crystal deposition seen in some patients infused with xylitol.
mesh_terms: D000818:Animals; D007263:Infusions, Parenteral; D008297:Male; D010070:Oxalates / Q000378:metabolism*; D011736:Pyridoxine / Q000378:metabolism; D051381:Rats; D013831:Thiamine / Q000378:metabolism; D013832:Thiamine Deficiency / Q000378:metabolism*; D026681:Vitamin B 6 Deficiency / Q000378:metabolism*; D014993:Xylitol / Q000008:administration & dosage*
chemical_list: D010070:Oxalates; D011736:Pyridoxine; D014993:Xylitol; D013831:Thiamine