A potent pancreatic carcinogen in Syrian hamsters: N-nitrosobis(2-oxopropyl)amine.
N-Nitrosobis(2-oxopropyl)amine (BOP), a further postulated beta-metabolite of di-n-propylnitrosamine, induced a high incidence of pancreatic duct adenomas and adenocarcinomas as early as 13 weeks in Syrian hamsters receiving weekly sc injections for life and a few pancreatic adenomas, after 28 weeks, in those given a single sc dose. Compared to related compounds, N-nitrosobis(2-hydroxypropyl)amine and N-nitrosobis(2-acetoxy-propyl)amine which are also pancreatic carcinogens, BOP induced only a few neoplasms of the lung, liver, and kidney and none in the nasal cavity, larynx, and trachea. The results therefore indicate progress in developing a more specific model for pancreatic carcinogenesis studies.
D000230:Adenocarcinoma / Q000139:chemically induced* / Q000473:pathology; D000236:Adenoma / Q000139:chemically induced*; D000818:Animals; D002273:Carcinogens; D006224:Cricetinae; D005260:Female; D005706:Gallbladder Neoplasms / Q000139:chemically induced; D008113:Liver Neoplasms / Q000139:chemically induced; D008175:Lung Neoplasms / Q000139:chemically induced; D008297:Male; D008647:Mesocricetus; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology; D009602:Nitrosamines / Q000008:administration & dosage / Q000633:toxicity*; D010183:Pancreatic Ducts; D010190:Pancreatic Neoplasms / Q000139:chemically induced* / Q000473:pathology; D014565:Urogenital Neoplasms / Q000139:chemically induced
D002273:Carcinogens; D009602:Nitrosamines