[Further study of the patterns of penicillin active transport in the kidney tubules of rabbits in vitro and in vivo].
A number of inhibitors of benzylpenicillin active transport in surviving sections of the abbit kidney cortex has been found for the first time. The capacity for such transport was shown with respect to all natural and semisynthetic penicillins tested. The section accumulation method was recommended for the use in screening new penicillins with prolonged action. Absence of corelation between the value of the section/medium concentration gradient and the index of penicillin kidney clearance was registered. It was shown that the binding level of penicillins by blood serum proteins did not define the rate of their excretion with the urine in rabbits.
D000818:Animals; D000838:Anions; D001693:Biological Transport, Active / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004734:Energy Metabolism; D005260:Female; D066298:In Vitro Techniques; D007684:Kidney Tubules / Q000378:metabolism*; D008297:Male; D010400:Penicillin G / Q000378:metabolism; D010406:Penicillins / Q000037:antagonists & inhibitors / Q000378:metabolism* / Q000652:urine; D011817:Rabbits; D013997:Time Factors
D000838:Anions; D010406:Penicillins; D010400:Penicillin G
Dal'neíshee izuchenie zakonomernostei aktivnogo transporta penitsillinov v kanal'tsakh pochek krolikov in vitro i in vivo