The determination of aspirin levels in the presence of hyperbilirubinemia.
Many major medical centers are presently utilizing a shortened method (Keller) for determining serum aspirin levels which does not remove interfering compounds. This report documents that the presence of even 1 mg of bilirubin/dl of serum is sufficient to cause a falsely high aspirin level. It is suggested that any method for determining serum bilirubin which does not remove interfering substances constitutes a danger to many groups of patients and should be discontinued.
D001241:Aspirin / Q000097:blood*; D001774:Blood Chemical Analysis / Q000379:methods; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000097:blood*; D008431:Maternal-Fetal Exchange; D008722:Methods; D011247:Pregnancy
D001241:Aspirin