Taste aversion disruption by drug pretreatment: dissociative and drug-specific effects.
Disruption of taste aversion learning following the administration of the same drug prior to and during conditioning (intra-agent disruption) was shown to be greater than disruption following the administration of one drug prior to conditioning and another during conditioning (inter-agent disruption). Comparable dosages of ethanol and lithium chloride served as unconditioned stimuli. Inter-agent disruptions are attributed to a dissociation of conditioned and unconditioned stimuli, while intra-agent disruptions are attributed to both a dissociative effect and drug-specific effects. Intra-agent disruption was correlated with an independent measure of tolerance, suggesting tolerance constitutes at least a portion of the drug-specific effects.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D003213:Conditioning, Psychological / Q000187:drug effects*; D004326:Drinking / Q000187:drug effects; D004361:Drug Tolerance; D000431:Ethanol / Q000494:pharmacology; D008094:Lithium / Q000494:pharmacology; D008297:Male; D004856:Postural Balance / Q000187:drug effects; D051381:Rats; D012439:Saccharin; D013649:Taste; D013997:Time Factors
D000431:Ethanol; D008094:Lithium; D012439:Saccharin