Dominant lethal studies with technical chlordane, HCS-3260, and heptachlor: heptachlor epoxide.
Male albino mice in groups of eight were each given single doses, either by gavage or by intraperitoneal injection, of either technical chlordane (50 or 100 mg/kg), HCS-3260 (50 or 100 mg/kg), or heptachlor:heptachlor epoxide (25:75) (7.5 or 15 mg/kg). The males were subsequently mated with three untreated females for six consecutive weeks. No dominant lethal changes among females that had mated with the treated males were produced.
D000818:Animals; D002706:Chlordan / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000633:toxicity; D004032:Diet; D004622:Embryo, Mammalian / Q000187:drug effects; D005260:Female; D005799:Genes, Dominant / Q000187:drug effects*; D005804:Genes, Lethal / Q000187:drug effects*; D006533:Heptachlor / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000633:toxicity; D006534:Heptachlor Epoxide / Q000494:pharmacology* / Q000633:toxicity; D008297:Male; D009153:Mutagens; D011247:Pregnancy; D051381:Rats
D009153:Mutagens; D006534:Heptachlor Epoxide; D002706:Chlordan; D006533:Heptachlor