Biosynthesis of streptolidine moiety of streptothricins by Streptomyces noursei JA 3890b.
The incorporation of uniformly 14C-labeled compounds into the streptothricin-type antibiotic nourseothricin was studied with a strain of Streptomyces noursei JA 3890b. 6.5% of radioactivity from U-14C-L-arginine was incorporated into the antibiotic, while glutamic acid, aspartic acid, alanine, proline, glycine and leucine displayed much lower incorporations. Furhtermore, 95% of the activity incorporated from arginine was located in the streptolidine moiety supporting the suggestion that this subunit of streptothricin antibiotics is formed via the dehydroarginine pathway.
D000596:Amino Acids / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D005947:Glucose / Q000378:metabolism; D006868:Hydrolysis; D013302:Streptomyces / Q000378:metabolism*; D013309:Streptothricins / Q000096:biosynthesis*
D000596:Amino Acids; D000900:Anti-Bacterial Agents; D013309:Streptothricins; D005947:Glucose