Effects of chronic vanadium pentoxide administration on L-ascorbic acid metabolism in rats: influence of L-ascorbic acid supplementation.
1. Rats toxicated with vanadium pentoxide showed drastic retardation in growth rate and supplementation of L-ascorbic acid to these rats could not reverse this effect. The urinary excretion of L-ascorbic acid and D-glucuronic acid was decreased in the toxicated group of rats. 2. Considerable lowering of L-ascorbic acid content of the liver tissues of rats was observed under vanadium toxicated conditions. Supplementation of L-ascorbic acid to this group raised the tissue Vitamin C reserve considerably. 3. The normal histological patterns of the liver and kidney tissues of rats were severely disturbed under vanadium toxicated conditions. L-ascorbic acid supplementation to this group of rats showed marked signs of restoration in this respect. 4. Vanadium pentoxide treatment brought about a significant reduction in the biosynthetic capacity of L-ascorbic acid, along with an enhanced utilization of this vitamin. Subsequent supplementation of L-ascorbic acid to the toxicated group of rats was found to be effective in reversing these effects almost to the basal level.
D000818:Animals; D001205:Ascorbic Acid / Q000096:biosynthesis / Q000378:metabolism* / Q000652:urine; D001835:Body Weight / Q000187:drug effects; D005965:Glucuronates / Q000096:biosynthesis / Q000652:urine; D006130:Growth Disorders / Q000139:chemically induced; D006454:Hemoglobins / Q000032:analysis; D007668:Kidney / Q000378:metabolism / Q000473:pathology; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D013997:Time Factors; D014639:Vanadium / Q000506:poisoning*
D005965:Glucuronates; D006454:Hemoglobins; D014639:Vanadium; D001205:Ascorbic Acid