Microglandular hyperplasia in vaginal adenosis associated with oral contraceptives and prenatal diethylstilbestrol exposure.
Eight cases of microglandular hyperplasia arising in vaginal adenosis are presented. Five of the patients were known to have taken oral contraceptives and a sixth was pregnant at the time the lesion was discovered; a history of prenatal exposure to diethylstilbestrol (DES) was present in 5 cases. It is important to differentiate microglandular hyperplasia, which is benign, from clear cell adenocarcinoma, which also arises in a background of vaginal adenosis.
D000230:Adenocarcinoma / Q000175:diagnosis; D000293:Adolescent; D000328:Adult; D002584:Cervix Uteri / Q000473:pathology; D003276:Contraceptives, Oral / Q000009:adverse effects*; D003937:Diagnosis, Differential; D004054:Diethylstilbestrol / Q000009:adverse effects*; D005260:Female; D005333:Fetus / Q000187:drug effects*; D006801:Humans; D006965:Hyperplasia; D011247:Pregnancy; D014621:Vagina / Q000473:pathology; D014623:Vaginal Diseases / Q000139:chemically induced* / Q000175:diagnosis; D014625:Vaginal Neoplasms / Q000175:diagnosis
D003276:Contraceptives, Oral; D004054:Diethylstilbestrol