title: Condyloma acuminatum and squamous carcinoma of the vulva.
abstract: Reported is the association of condyloma acuminatum and squamous carcinoma of the vulva in three cases and condyloma followed by squamous dysplasia in a fourth case. This association has previously been reported in both male and female genitalia and in the perianal area. In our four cases, cancer or squamous dysplasia followed long-standing or extensive condyloma, but there was no evidence of transformation from condyloma to carcinoma. In one of the cases, areas of squamous dysplasia occurred in multiple foci within a large condyloma. It is not known whether condyloma acuminatum is a precancerous skin lesions, but long-standing or extensive condylomas should alert one to the possibility of carcinoma.
mesh_terms: D000328:Adult; D000368:Aged; D002291:Carcinoma, Papillary / Q000150:complications / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000473:pathology; D003218:Condylomata Acuminata / Q000150:complications* / Q000473:pathology; D005260:Female; D006801:Humans; D009378:Neoplasms, Multiple Primary; D011230:Precancerous Conditions / Q000473:pathology; D014846:Vulvar Neoplasms / Q000150:complications* / Q000473:pathology