Effect of prostaglandin F2alpha-THAM in the bitch.
The subcutaneous median lethal dosage for prostaglandin F2alpha for the Beagle bitch was determined to be 5.13 mg/kg, using a sequential experimental design. Clinical signs and gross and histologic findings were consistent with a diagnosis of shock syndrome. It was concluded that prostaglandin F2alpha could be used to develop a pharmacologically controlled shock model.
D000818:Animals; D004283:Dog Diseases / Q000139:chemically induced*; D004285:Dogs; D005260:Female; D007279:Injections, Subcutaneous; D007928:Lethal Dose 50; D011460:Prostaglandins F / Q000008:administration & dosage / Q000633:toxicity*
D011460:Prostaglandins F