[Effect of actinomycin D and ethionine on hormonal induction of ribonucleic acid synthesis in the nuclei and cytoplasm of the liver cells of adult male rats].
Ethionine did not affect but actinomycin D inhibited the increase in DNA-like RNA synthesis (precursor of ribosomal RNA in nuclei and rRNA in cytoplasm of liver tissue cells of adult male rats), which was caused by single administration of hydrocortisone or protamine-Zn-insulin and by both hormones. The data obtained suggest that the effect of these hormones on the synthesis of DNA-like RNA was realized at the stage of transcription.
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D003609:Dactinomycin / Q000494:pharmacology*; D005001:Ethionine / Q000494:pharmacology*; D006854:Hydrocortisone / Q000494:pharmacology; D049528:Insulin, Long-Acting / Q000494:pharmacology; D008099:Liver / Q000378:metabolism*; D008297:Male; D012313:RNA / Q000096:biosynthesis*; D012335:RNA, Ribosomal / Q000096:biosynthesis; D051381:Rats; D014158:Transcription, Genetic / Q000187:drug effects
D049528:Insulin, Long-Acting; D012335:RNA, Ribosomal; D003609:Dactinomycin; D012313:RNA; D006854:Hydrocortisone; D005001:Ethionine
Vliianie aktinomitsina D i étionina na gomonal'nuiu induktsiiu sinteza ribonukleinovykh kislot v iadrakh i tsitoplazme kletok pecheni polovozrelykh krys-samtsov