In vivo inhibition of platelet MAO activity by tricyclic antidepressants.
Platelet MAO activity decreased by 40% (p less than .001) in a group of 11 male patients with primary depression after 3 weeks of treatment with either amitriptyline or imipramine. This finding, together with data from previous in vitro studies demonstrating tricyclic-induced inhibition of mitochondrial MAO, suggests that inhibition of MAO plays a role in the clinical action of tricyclic antidepressant drugs.
D000328:Adult; D000639:Amitriptyline / Q000494:pharmacology* / Q000627:therapeutic use; D001792:Blood Platelets / Q000187:drug effects* / Q000201:enzymology; D003863:Depression / Q000097:blood / Q000188:drug therapy; D006801:Humans; D007099:Imipramine / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000097:blood; D008996:Monoamine Oxidase Inhibitors; D013997:Time Factors
D008996:Monoamine Oxidase Inhibitors; D000639:Amitriptyline; D008995:Monoamine Oxidase; D007099:Imipramine