Attempts to boost tuberculin skin reactions by serum or blood transfer in BCG-vaccinated guinea-pigs.
In persons with waning sensitivity to mycobacterial antigens, skin reactivity to tuberculin may be maintained or enhanced as a result of tuberculin testing. Similar phenomena have been observed in guinea-pigs. As tuberculin testing may lead to antibody formation, the "booster" effect might be due to circulating antibody. However, a series of nine pilot experiments including blood and serum transfer from boosted to unboosted BCG-vaccinated guinea-pigs gave no support to this hypothesis.
D000818:Animals; D000917:Antibody Formation; D001500:BCG Vaccine; D001803:Blood Transfusion; D005260:Female; D006168:Guinea Pigs; D007117:Immunization, Secondary; D008297:Male; D014374:Tuberculin Test
D001500:BCG Vaccine