title: Inhibition of initiation, elongation, and termination of eukaryotic protein synthesis by trichothecene fungal toxins.
abstract: The 12,13-epoxytrichothecenes, specific inhibitors of protein synthesis in eukaryotes, can be subdivided further in terms of their mode of action. In addition to the I-type (initiation inhibitors) and E-types (elongation inhibitors), we found that some E-types apparently exhibit inhibition of chain termination at low concentrations. The nature of substituents on C4 may determine the type of inhibitory activity observed.
mesh_terms: D002499:Centrifugation, Density Gradient; D003864:Depression, Chemical; D006367:HeLa Cells / Q000378:metabolism; D007930:Leucine / Q000378:metabolism; D010441:Peptide Chain Elongation, Translational / Q000187:drug effects; D010442:Peptide Chain Initiation, Translational / Q000187:drug effects; D010443:Peptide Chain Termination, Translational / Q000187:drug effects; D011132:Polyribosomes / Q000187:drug effects; D014176:Protein Biosynthesis / Q000187:drug effects*; D012270:Ribosomes / Q000187:drug effects; D012717:Sesquiterpenes / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014255:Trichothecenes / Q000494:pharmacology*
chemical_list: D012717:Sesquiterpenes; D014255:Trichothecenes; D007930:Leucine