Serum lipid-lowering properties of 6-chloro-9-[2-(6-methyl-3-pyridyl)ethyl]-1,2,3,4-tetrahydrocarbazole-2-carboxylic acid.
6-Chloro-9-[2-(6-methyl-3-pyridyl)ethyl]-1,2,3,4-tetrahydrocarbazole-2-carboxylic acid hydrochloride lowered serum cholesterol, triglyceride, phospholipid, and free fatty acid levels in normal rats. The compound appeared to have a low toxicity and to be well tolerated in mice, adult and neonatal rats, and rabbits. At hypolipidemic doses, it caused a slight hepatomegaly associated with an increase in liver phospholipid and protein content. Liver N-demethylase and catalase activities were increased by the drug treatment. This acid had no in vitro antilipolytic activity and did not affect serum desmosterol-cholesterol ratios. The results indicate that it has a mechanism of action similar to clofibrate.
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D002227:Carbazoles / Q000494:pharmacology* / Q000633:toxicity; D002374:Catalase / Q000378:metabolism; D002849:Chromatography, Gas; D003864:Depression, Chemical; D005037:Ethylmorphine-N-Demethylase / Q000378:metabolism; D006949:Hyperlipidemias / Q000097:blood / Q000503:physiopathology; D000960:Hypolipidemic Agents; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D011506:Proteins / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D013261:Sterols / Q000097:blood; D013347:Subcellular Fractions / Q000378:metabolism; D014280:Triglycerides / Q000097:blood
D002227:Carbazoles; D000960:Hypolipidemic Agents; D008055:Lipids; D011506:Proteins; D013261:Sterols; D014280:Triglycerides; D002374:Catalase; D005037:Ethylmorphine-N-Demethylase