Immunization with influenza vaccine in patients with haematological malignant disease.
Fifty-eight patients with a variety of haematological lymphoproliferative or myeloproliferative disorders were given bivalent subunit influenza virus vaccine, and their antibody responses after vaccination were compared with those of a normal control group. Although geometric mean titres of the patient group showed lower initial antibody levels, smaller increments, and lower final titres, after vaccination 83% of this group achieved satisfactory antibody levels to the A/Pt Chalmers strain, and 57% to the B/Hong Kong strain. The lowest antibody levels and smallest responses occurred in patients with non-Hodgkin's lymphoma, Hodgkin's disease, and multiple myeloma. Four of seven patients who showed low antibody levels, and no response to the first injection, responded to a second dose.
D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis*; D006402:Hematologic Diseases / Q000276:immunology*; D006689:Hodgkin Disease / Q000276:immunology; D006801:Humans; D007252:Influenza Vaccines; D008223:Lymphoma / Q000276:immunology; D008875:Middle Aged; D009101:Multiple Myeloma / Q000276:immunology; D009975:Orthomyxoviridae / Q000276:immunology*; D014611:Vaccination
D000914:Antibodies, Viral; D007252:Influenza Vaccines