title: Autoimmune haemolytic anaemia with the unusual combination of both IgM and IgG autoantibodies.
abstract: Two patients with autoimmune haemolytic anaemia of no obvious aetiology are presented. Both cases had IgM autoantibodies which were cold agglutinins with anti-I specificity and were complement binding. Both cases also had IgG autoantibodies which were incomplete, of wide thermal range and also had anti-I specificity, but were not complement binding. The red cells of both patients were coated with C4/C3d and IgG.
mesh_terms: D000328:Adult; D000373:Agglutinins; D000744:Anemia, Hemolytic, Autoimmune / Q000276:immunology*; D000918:Antibody Specificity; D001323:Autoantibodies; D003080:Cold Temperature; D003165:Complement System Proteins; D005260:Female; D006801:Humans; D007048:I Blood-Group System; D007074:Immunoglobulin G; D007075:Immunoglobulin M
chemical_list: D000373:Agglutinins; D001323:Autoantibodies; D007048:I Blood-Group System; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D003165:Complement System Proteins