Glomerular lesions in argyric NZB/NZW mice.
Glomerular basement membranes showed strong silver labelling on electron microscopy in NZB/NZW mice fed 12 mmol AgNO3 for 6 weeks at ages from 1-7 months. Although some silver granules were seen within mesangial immune deposits following their concurrent deposition, silver was usually deposited in electron-lucent areas around pre-existing deposits, or formed a boundary to an expanded mesangium when immune deposits subsequently developed. Immune deposits in capillary loops occurred on the outer or inner aspect of the zone of silver labelling.
D000818:Animals; D000936:Antigen-Antibody Complex; D001485:Basement Membrane / Q000648:ultrastructure; D005260:Female; D007678:Kidney Glomerulus / Q000276:immunology / Q000648:ultrastructure*; D051379:Mice; D008854:Microscopy, Electron; D012835:Silver Nitrate
D000936:Antigen-Antibody Complex; D012835:Silver Nitrate