A new aminoglycoside antibiotic complex--the seldomycins. III. The structures of seldomycin factors 1 and 2+.
The structures of seldomycin factors 1 and 2 have been determined by consideration of chemical degradation and spectral properties. Factor 1, also known as XK-88-1, is shown to be 6-O-(2-amino-2-deoxy-alpha-D-xylopyranosyl) paromamine (1) and factor 2, also known as XK-88-2, is shown to be 4'-deoxy-neamine (2). Mass spectral evidence has been obtained that suggests the most probable structure for seldomycin factor 3, also known as XK-88-3, is 6'-amino-6'-deoxyseldomycin factor 1 (12).
D000606:Amino Sugars / Q000302:isolation & purification; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D055598:Chemical Phenomena; D002621:Chemistry; D006868:Hydrolysis; D013058:Mass Spectrometry; D008722:Methods; D008968:Molecular Conformation; D010084:Oxidation-Reduction
D000606:Amino Sugars; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents