[Effect of a new cholinesterase reactivator, diethixime, on the central nervous system].
A new cholinesteras reactivator--chlorohydrate of S-diethylaminoethyl ether p-bromo benzoylthiohydroxime acid (diethixime), containing a tertiary nitrogen atom in the molecule, was shown to produce a central effect in a dose of 20 mg/kg--1/50 LD50--in contrast to diproxime in a dose of 3 mg/kg, containing a quarternary nitrogen atom, under intoxication of albino rats and rabbits with dimethyl-dichlorynylphosphate. This effect was confirmed by the restortion of the cholinesterase activity in different parts of the rabbit brain, by the normalization of the EEGand of the functional stateof motor neurons of the rat spinal cord.
D000110:Acetylcholinesterase / Q000378:metabolism; D000208:Acute Disease; D000818:Animals; D001921:Brain / Q000201:enzymology / Q000503:physiopathology; D002801:Cholinesterase Reactivators / Q000627:therapeutic use*; D004006:Dichlorvos / Q000506:poisoning*; D004048:Diethylamines / Q000627:therapeutic use; D004569:Electroencephalography; D006877:Hydroxamic Acids / Q000627:therapeutic use*; D009046:Motor Neurons; D011817:Rabbits; D051381:Rats; D013116:Spinal Cord / Q000503:physiopathology
D002801:Cholinesterase Reactivators; D004048:Diethylamines; D006877:Hydroxamic Acids; D004006:Dichlorvos; D000110:Acetylcholinesterase
Deĭstvie novogo reaktivatora kholinĕsterazy diétiksima na tsentral'nuiu nervnuiu sistemu