title: Effect of acute unilateral renal denervation on tubular sodium reabsorption in the dog.
abstract: The effects of acute denervation of the kidney on renal tubular sodium and water excretion were studied in anesthetized, hypophysectomized, and cortisone-treated mongrel dogs during stable water diuresis produced by the infusion of 2.5% dextrose. In all experiments, denervation natriuresis, and diuresis were observed without significant change in glomerular filtration rate (GRF) and renal plasma flow (RPF). Fractional sodium delivery to the distal nephron (CNa + CH2O/100 ml GFR) and fractional free water clearance (CH23/100 ml GFR) was significantly greater in the denervated kidney compared with the innervated kidney (9.6+/-1.2 vs. 6.7+/-0.9% and 8.8+/-1.2 vs. 6.5+/-0.8%, respectively). Distal tubular sodium reabsorption (CH2O/(CNa + CH2O)) was not significantly different. We conclude that renal denervation primarily affects the proximal tubule as manifested by a decrease in the reabsorption of sodium and water. A small effect of denervation on the distal nephron is not completely ruled out.
mesh_terms: D000818:Animals; D003348:Cortisone / Q000494:pharmacology; D003714:Denervation; D004285:Dogs; D007016:Hypophysectomy; D007668:Kidney / Q000294:innervation*; D007684:Kidney Tubules / Q000378:metabolism*; D009318:Natriuresis; D011188:Potassium / Q000378:metabolism; D012964:Sodium / Q000378:metabolism*; D014867:Water
chemical_list: D014867:Water; D012964:Sodium; D011188:Potassium; D003348:Cortisone