title: Chronic human schistosomiasis mansoni. Pathology of the Disse's space.
abstract: In chronic human schistosomiasis mansoni, the entire hepatic lobule is involved. The hepatovascular barrier is modified and shows hepatic sinusoids with hypertrophy and stratification of endothelium, basement membrane-like deposits, perisinusoidal fibrosis, diminution of hepatocellular microvilli and hepatocellular clasmatosis into the sinusoidal circulation. This transformation of an open circulation to a partly closed one may decrease the blood hepatocyte exchanges in schistosomiasis mansoni.
mesh_terms: D003593:Cytoplasm / Q000648:ultrastructure; D004727:Endothelium / Q000648:ultrastructure; D006801:Humans; D007728:Kupffer Cells / Q000648:ultrastructure; D008099:Liver / Q000473:pathology* / Q000648:ultrastructure; D008109:Liver Diseases, Parasitic / Q000473:pathology*; D008854:Microscopy, Electron; D010873:Pinocytosis; D012552:Schistosomiasis / Q000473:pathology*