title: [S-adenosylmethionine as a regulator of protein synthesis. Influence on plasmatic fibrinogen].
abstract: S-adenosyl-L-methionine (SAMe) is a physiological compound which plays an important role in numerous biological processes, such as transmethylations, transulphurations and aminopropylations. Starting from a study about the usefulness of the SAMe to normalize protein synthesis in old age, the drug was found to have an interesting action with respect to fibrinogen. Later research regarding a large number of patients, led us to discover after treatment for 40 days with 60 mg/die of SAMe, highly significant variations in fibrinogen values with constant normalization of this parameter, in both hypo- and hyper-fibrinogenemia. So far we don't know anything about the action of the drug on various metabolic stages of the fibrinogen; interestingly however our data exclude a rise in fibrinolysis.
mesh_terms: D000328:Adult; D000368:Aged; D001799:Blood Sedimentation; D001809:Blood Viscosity; D002908:Chronic Disease; D005260:Female; D005340:Fibrinogen / Q000096:biosynthesis*; D006801:Humans; D008107:Liver Diseases / Q000097:blood / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D012436:S-Adenosylmethionine / Q000494:pharmacology* / Q000627:therapeutic use; D013916:Thrombelastography
chemical_list: D012436:S-Adenosylmethionine; D005340:Fibrinogen
vernacular_title: La S-adenosil-metionina come regolatore dell sintesi proteiche. Influenza sul fibrinogeno plasmatico