Reversal of ineffective erythropoiesis in pernicious anaemia following vitamin B12 therapy.
Ineffective erythropoiesis was quantitated in a series of patients with pernicious anaemia at different times in relation to vitamin B12 therapy by measuring the incorporation of [15N]delta aminolaevulinic acid and [15N]glycine into early labelled bilirubin. Prior to therapy ineffective erythropoiesis was grossly increased but this was reversed within 24 h of giving vitamin B12, suggesting that most of the existing megaloblasts are enabled to mature into circulating red cells.
D000368:Aged; D000622:Aminolevulinic Acid / Q000378:metabolism; D000752:Anemia, Pernicious / Q000188:drug therapy* / Q000378:metabolism; D001663:Bilirubin / Q000378:metabolism; D004920:Erythropoiesis / Q000187:drug effects; D005260:Female; D005998:Glycine / Q000378:metabolism; D006418:Heme / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D014805:Vitamin B 12 / Q000627:therapeutic use*
D006418:Heme; D000622:Aminolevulinic Acid; D014805:Vitamin B 12; D001663:Bilirubin; D005998:Glycine