[Detection of 3 beta-hydroxy-5-cholenoic acid in human amniotic fluid].
Studies of the bile acids of human meconium suggest that a fetal pathway of bile acid synthesis exists which leads to formation of 3beta-hydroxy-5-cholenoic acid, a bile acid not found in serum of healthy pregnant women. To obtain additional support for this hypothesis, cholic, chenodeoxycholic, and 3beta-hydroxy-5-cholenoic acid were measured in amniotic fluid specimens from 18 pregnant women without liver disease. The finding of a considerable percentage of 3beta-hydroxy-5-cholenoic acid (mean: 34 molar %; range 3-71 molar % of total bile acids) in amniotic fluid strengthens the hypothesis that a fetal pathway of bile acid synthesis exists which begins with oxidation of the cholesterol side chain.
D000293:Adolescent; D000328:Adult; D000653:Amniotic Fluid / Q000032:analysis*; D001647:Bile Acids and Salts / Q000032:analysis* / Q000378:metabolism; D005260:Female; D005333:Fetus / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000196:embryology; D011247:Pregnancy
D001647:Bile Acids and Salts
Nachweis von 3beta-Hydroxy-5-cholensäure im menschlichen Fruchtwasser