title: Correlation between antiinflammatory and antiproteolytic properties of substituted benzylidenes.
abstract: Twelve substituted benzylidenes were evaluated for antiinflammatory activity against carrageenin-induced edema in rats. The protection afforded by these compounds at a dose of 100 mg/kg, i.p., ranged from 30 to 60%. Sodium salicylate (100 mg/kg, i.p.), used as a reference drug, exhibited a 30% antiinflammatory activity under similar experimental conditions. The in vitro effects of substituted benzylidenes were also investigated on the activity of trypsin during hydrolysis of bovine serum albumin, serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, and endogenous lipid peroxide formation by liver homogenates. These results have provided some correlation between antiinflammatory and antiproteolytic properties of substituted benzylidenes.
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents; D001597:Benzylidene Compounds / Q000494:pharmacology* / Q000627:therapeutic use; D004341:Drug Evaluation; D004487:Edema / Q000188:drug therapy; D006868:Hydrolysis; D066298:In Vitro Techniques; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism; D010545:Peroxides / Q000096:biosynthesis; D051381:Rats; D013329:Structure-Activity Relationship; D000637:Transaminases / Q000037:antagonists & inhibitors; D014361:Trypsin Inhibitors
chemical_list: D000893:Anti-Inflammatory Agents; D001597:Benzylidene Compounds; D010545:Peroxides; D014361:Trypsin Inhibitors; D000637:Transaminases