Effects of exogenous fatty acids on growth and enterotoxin B formation by Staphylococcus aureus 14458 and its membrane mutant.
Growth and enterotoxin B (SEB) formation by Staphylococcus aureus 14458 and its membrane mutant can be depressed or stimulated by addition of graded amounts of saturated or unsaturated fatty acid mixtures. Under some conditions depression of SEB formation is separable from growth inhibition. Individual fatty acids most active in altering growth and (or) SEB production have been identified. Small amounts of unsaturated fatty acid mixture not only antagonize some effects of saturated fatty acid mixtures, but also appear to potentiate inhibition of growth and SEB formation by the saturated fatty acid mixture. 2-Admantanone, a compound which increases cell membrane fluidity, strongly suppresses SEB formation while stimulating growth. The results are discussed in relation to possible effects of exogenous fatty acids on the composition of membrane phospholipids and attendant changes in SEB production.
D000218:Adamantane / Q000494:pharmacology; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D004768:Enterotoxins / Q000096:biosynthesis*; D005227:Fatty Acids / Q000494:pharmacology*; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D009154:Mutation; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism
D004768:Enterotoxins; D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D000218:Adamantane