title: Nature of histamine receptors concerned in capillary permeability.
abstract: 1 Histamine and 2-methyl-histamine (H1-receptor agonist) caused dose-dependent increases in capillary permeability in albino mice, but 4-methyl-histamine (H2-receptor agonist) caused no significant increase. 2 Mepyramine (H1-receptor antagonist) blocked the histamine-induced increase in capillary permeability whereas burimamide (H2-receptor antagonist) produced no significant blockade of the histamine-response. 3 Combined mepyramine and burimamide pretreatment did not give any significantly greater protection than mepyramine alone. 4 The results indicate involvement of the H1-receptors in histamine-induced increase in capillary permeability.
mesh_terms: D000818:Animals; D002049:Burimamide / Q000494:pharmacology; D002199:Capillary Permeability / Q000187:drug effects; D004347:Drug Interactions; D005260:Female; D006632:Histamine / Q000494:pharmacology; D008297:Male; D008761:Methylhistamines / Q000494:pharmacology; D051379:Mice; D011738:Pyrilamine / Q000494:pharmacology; D011968:Receptors, Histamine / Q000502:physiology*; D011969:Receptors, Histamine H1 / Q000187:drug effects / Q000502:physiology; D011970:Receptors, Histamine H2 / Q000187:drug effects / Q000502:physiology
chemical_list: D008761:Methylhistamines; D011968:Receptors, Histamine; D011969:Receptors, Histamine H1; D011970:Receptors, Histamine H2; D006632:Histamine; D011738:Pyrilamine; D002049:Burimamide