Plasma lactate dehydrogenase activity will be increased if detergent and platelets are present.
Plasma lactate dehydrogenase activity is artifactually increased when analyzed on the SMAC (Technicon) continuous-flow analyzer. The factors responsible are incomplete centrifugation and the presence of detergent in the dilution buffer. The contribution of platelet lactate dehydrogenase in the plasma is demonstrated with a case of thrombocytosis.
D001792:Blood Platelets / Q000201:enzymology*; D002498:Centrifugation; D005189:False Positive Reactions; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D008722:Methods; D010949:Plasma / Q000201:enzymology*; D011092:Polyethylene Glycols / Q000494:pharmacology*; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*; D013922:Thrombocytosis / Q000201:enzymology
D000644:Quaternary Ammonium Compounds; D011092:Polyethylene Glycols; D007770:L-Lactate Dehydrogenase