The effect of loperamide on prostaglandin induced diarrhoea in rat and man.
Loperamide, a new antidiarrhoeal compound, effectively antagonised prostaglandin induced diarrhoea in adult healthy male volunteers and in patients undergoing pregnancy termination with prostaglandins. This compound is effective in inhibiting prostaglandin induced fluid accumulation in the small intestine in rats. Loperamide also blocked smooth muscle stimulating action of prostaglandins, acetylcholine and histamine on gastrointestinal smooth muscle preparations from several laboratory animals.
D000028:Abortion, Induced; D000818:Animals; D006224:Cricetinae; D003967:Diarrhea / Q000188:drug therapy*; D004353:Drug Evaluation, Preclinical; D005260:Female; D006801:Humans; D008139:Loperamide / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010880:Piperidines / Q000494:pharmacology*; D011247:Pregnancy; D011448:Prostaglandin Antagonists; D011458:Prostaglandins E / Q000037:antagonists & inhibitors* / Q000494:pharmacology / Q000627:therapeutic use; D011460:Prostaglandins F / Q000037:antagonists & inhibitors* / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats
D010880:Piperidines; D011448:Prostaglandin Antagonists; D011458:Prostaglandins E; D011460:Prostaglandins F; D008139:Loperamide