title: Effect of multiple injections of antigen on prolonged IgE antibody production in hypersensitive mice.
abstract: Multiple injections of ovomucoid were given to mice with ongoing prolonged IgE antibody production to that antigen. Two inbred strains and antigen doses ranging from 0.05 to 5 mug each injection, given intradermally and subcutaneously, were used. Mice treated in this manner showed a marked diminution of the Ig E antibody booster response as compared to controls. This decrease in booster response was antigen-specific. In addition, a protective effect from anaphylaxis was indicated. The mouse model continues to be a valuable tool for studies of certain IgE-mediated diseases.
mesh_terms: D000707:Anaphylaxis / Q000517:prevention & control; D000818:Animals; D000917:Antibody Formation; D003888:Desensitization, Immunologic; D004527:Egg Proteins / Q000276:immunology*; D005260:Female; D007117:Immunization, Secondary; D007073:Immunoglobulin E; D007074:Immunoglobulin G / Q000096:biosynthesis; D051379:Mice; D008815:Mice, Inbred Strains; D010059:Ovomucin / Q000276:immunology*; D010323:Passive Cutaneous Anaphylaxis
chemical_list: D004527:Egg Proteins; D007074:Immunoglobulin G; D010059:Ovomucin; D007073:Immunoglobulin E