[Influence of levamisole on antibody production].
IgM and IgG anti-sheep red blood cells agglutinins were measured from dayy + 2 to day + 30 in SPF mice immunized with 108 SRC and treated with 2.5 or 25 mg LMS/dg. Untreated control mice produced high levels (1:8200) of IgM-antibodies from day + 4 to day + 20. Early, day + 4, IgG-agglutinins appeared together with IgM-antibodies in mice treated with 2.5 mg LMS/kg, whereas administration of 25 mg LMS/kg induced the synthesis of antibodies belonging only to the IgG class. Titres were significantly lower (1:512) in LMS-treated mice than in controls. The switch to IgG of antibody formation is another for the ability of LMS to stimulate T cell activities.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D005260:Female; D006388:Hemagglutinins / Q000032:analysis; D007074:Immunoglobulin G / Q000378:metabolism; D007075:Immunoglobulin M / Q000378:metabolism; D007978:Levamisole / Q000494:pharmacology*; D051379:Mice
D006388:Hemagglutinins; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007978:Levamisole
Influence du lévamisole sur la production d'anticorps