Pertussis vaccine: reactivity in animal and man.
Clinical investigation of the reactivity of diphtheria-tetanus-pertussis (DTP) vaccines is a routine control in the GDR. This paper shows the results of the clinical control of 26 batches of DTP vaccine in comparison with animal tests (weight-gain-test, histamine-sensitizing test, dermonecrotic test). The animal tests gave no support to innocuity. The batches were tested on 427 children and passed the requirements for reactivity. After a storage for 2 years the control of 3 different batches was repeated. Two of them showed side reactions in children in spite of the fact that the results of the weight-gain test did not change.
D000818:Animals; D001681:Biological Assay; D001835:Body Weight / Q000187:drug effects; D002675:Child, Preschool; D006168:Guinea Pigs; D006801:Humans; D007223:Infant; D008297:Male; D051379:Mice; D010567:Pertussis Vaccine / Q000633:toxicity*; D011309:Preservation, Biological; D011817:Rabbits; D013045:Species Specificity; D013997:Time Factors
D010567:Pertussis Vaccine