Effect of endogenous and exogenous glucagon on pentagastrin-stimulated lower esophageal sphincter pressure in man.
The effect of endogenously released pancreatic glucagon on pentagastrin-stimulated lower esophageal sphincter pressure (LES-P) was studied in 10 healthy subjects. Glucagon was released by continuous intravenous infusion of 1-arginine in a dose of 0.6 g/kg-h, which resulted in plasma concentrations of pancreatic glucagon comparable to those seen after a protein meal. Infusion of arginine resulted in a significant inhibition of pentagastrin (0.5 mug/kg-h) stimulated LES-P. Five of the subjects furthermore had a study of the effect of exogenous glucagon in a dose of 1.6 mjg/kg-h on pentagastrin-stimulated LES-P. This dose of glucagon also reduced LES-P, but in spite of higher plasma glucagon concentrations, to a lesser degree than arginine.
D000328:Adult; D001120:Arginine / Q000008:administration & dosage / Q000494:pharmacology; D004943:Esophagogastric Junction / Q000187:drug effects*; D005260:Female; D005934:Glucagon / Q000097:blood / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D008297:Male; D010179:Pancreas / Q000378:metabolism; D010418:Pentagastrin / Q000008:administration & dosage / Q000494:pharmacology*; D011312:Pressure
D005934:Glucagon; D001120:Arginine; D010418:Pentagastrin