Colchicine toxicity: a multisystem disease.
A 23-year-old black man survived a life-threatening multisystem disturbance resulting from a large single dose of colchicine administered intraurethrally for condyloma acuminata. Gastroenteritis and probable pancreatitis rapidly evolved into severe respiratory failure, marked neuromuscular problems, alopecia, and complete bone marrow aplasia. Within two months he had completely recovered. This patient demonstrates that colchicine should be used with extreme caution, if at all, for the therapy of condyloma acuminata.
D000328:Adult; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D003078:Colchicine / Q000008:administration & dosage / Q000009:adverse effects*; D003218:Condylomata Acuminata / Q000188:drug therapy; D006801:Humans; D008297:Male; D009468:Neuromuscular Diseases / Q000139:chemically induced; D012131:Respiratory Insufficiency / Q000139:chemically induced
D003078:Colchicine