title: A factor in yogurt which lowers cholesteremia in man.
abstract: Large dietary intakes of yogurt are found to lower cholestermia in man. This effect is associated with a reduction of incorporation of radioacetate into serum cholesterol. The effect appears slowly and persists after intake of the yogurt stops suggesting that the mechanism involves the synthesis of a regulatory protein rather than an allosteric effect. The effective agent is postulated to be hydroxymethyl glutarate which inhibits the regulatory enzyme hydroxymethyl glutaryl CoA reductase (EC 1.1.1.3.4).
mesh_terms: D000328:Adult; D003611:Dairy Products / Q000032:analysis*; D005260:Female; D005977:Glutarates / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism; D006937:Hypercholesterolemia / Q000178:diet therapy*; D008297:Male; D008875:Middle Aged
chemical_list: D005977:Glutarates; D006903:Hydroxymethylglutaryl CoA Reductases