[The influence of antiarrhythmic drugs on the exercise-ecg (author's transl)].
The influence of five most common antiarrhythmic drugs on exercise-electrocadiogram was investigated: prajmaliumbitartrat, quinidinbisulfate, diphenylhydantoine, propranolol, and verapamil. All exercise-tests were performed in eight healthy males. During exercise and the subsequent resting period, the changes in the following parameters were analysed: blood pressure, heart rate, P-Q-time, Q-T-time, and the formal course of the Ecg as well as individual reactions. None of the drugs produced a pathological ECG. As for the analysed parameters, diphenylhydantoine was entirely neutral, whereas propranolol caused the most significant changes. Propranolol lowered heart rate by more than 20% and blood pressure by 10%. Verapamil had a less pronounced effect on diastolic blood pressure and heart rate. Prajmaliumbitartrat and quinidine had no definite effect during exercise and resting period.
D000328:Adult; D000404:Ajmaline / Q000031:analogs & derivatives / Q000494:pharmacology; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D004562:Electrocardiography; D005080:Exercise Test; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008722:Methods; D010672:Phenytoin / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011802:Quinidine / Q000494:pharmacology; D014700:Verapamil / Q000494:pharmacology
D000889:Anti-Arrhythmia Agents; D000404:Ajmaline; D010672:Phenytoin; D011433:Propranolol; D014700:Verapamil; D011802:Quinidine
Der Einfluss von Antiarrhythmika auf das Belastungs--Ekg