Inhibition of histidine decarboxylase. Derivatives of histidine.
Twenty-eight derivatives of histidine were tested as inhibitors of histidine decarboxylase from rat stomach. Potent inhibition was observed with the methyl ester of L-histidine (1) which had a Ki = 1.8 X 10(-6) M. Substitution on 1 at various positions resulted in a decrease or complete loss of inhibition. Substituent requirements for inhibition of histidine decarboxylase are discussed. A simple disposable apparatus for the radiometric assay of histidine decarboxylase is described.
D000818:Animals; D002262:Carboxy-Lyases / Q000037:antagonists & inhibitors*; D006639:Histidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D006640:Histidine Decarboxylase / Q000037:antagonists & inhibitors*; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D051381:Rats; D013270:Stomach / Q000187:drug effects / Q000201:enzymology; D013329:Structure-Activity Relationship
D006639:Histidine; D002262:Carboxy-Lyases; D006640:Histidine Decarboxylase