Tolerance to the effects of delta9-THC on shuttle-box performance and body temperature.
Two groups of rats were trained in a shuttle-box and received delta9-tetrahydrocannabinol (delta9-THC), either before or after being tested. The drug-before group showed tolerance--within 3-6 sessions--to the response-inhibiting effect of THC. The drug-after animals appeared also to be tolerant when they received delta9-THC before being tested. It is concluded that the tolerance to this effect probably is not learned, but has a physiological base. This is corroborated by the finding that during the same study all the animals developed tolerance to the hypothermic effect of delta9-THC.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects*; D003216:Conditioning, Operant / Q000187:drug effects*; D013759:Dronabinol / Q000494:pharmacology*; D004361:Drug Tolerance; D008297:Male; D051381:Rats; D013997:Time Factors
D013759:Dronabinol