Spontaneous systemic lupus erythematosus and acelylator phenotype.
Fifteen patients with spontaneous systemic lupus erythematosus (SLE) have been phenotyped by determination of plasma isoniazid (INH) half-life. Seven patients had signs of renal insufficiency. Of the 15 patients, 13 were slow and only 2 rapid acetylators. No correlation was found between the plasma INH half-lives and the renal function. Thus, there is the same marked predominance of slow acetylators in patients with spontaneous SLE as in patients with the drug-induced SLE-like syndrome.
D000107:Acetylation; D000328:Adult; D000368:Aged; D002625:Chemistry, Organic; D005260:Female; D006207:Half-Life; D006801:Humans; D007538:Isoniazid / Q000097:blood; D007668:Kidney / Q000503:physiopathology; D008180:Lupus Erythematosus, Systemic / Q000235:genetics / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D055601:Organic Chemistry Phenomena; D010641:Phenotype
D007538:Isoniazid