title: [Effects of a proteolytic-enzyme preparation used concomitantly with an antibiotic in osteoarticular infections (author's transl)].
abstract: Studies were performed in 8 patients with osteoarticular infections to examine the concentrations of sulbenicillin in the venous blood and exudate following administration and the concentrations of the antibiotic in the exudate when serratiopeptidase was orally administered concomitantly with the antibiotic. The results of the examination indicated that the transfer of sulbenicillin into the exudate tended to increase when 30 mg/day of serratiopeptidase was concomitantly given for 6 days, though further examination was thought necessary by increasing number of subjects and elaborating on the methodology.
mesh_terms: D000328:Adult; D000368:Aged; D001847:Bone Diseases / Q000188:drug therapy* / Q000378:metabolism; D004359:Drug Therapy, Combination; D005122:Exudates and Transudates / Q000737:chemistry; D005260:Female; D006801:Humans; D007592:Joint Diseases / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009187:Myelitis / Q000188:drug therapy / Q000378:metabolism; D010400:Penicillin G / Q000031:analogs & derivatives*; D010447:Peptide Hydrolases / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D013408:Sulbenicillin / Q000008:administration & dosage / Q000378:metabolism* / Q000627:therapeutic use
chemical_list: D010447:Peptide Hydrolases; C022640:serratiopeptidase; D013408:Sulbenicillin; D010400:Penicillin G