[Effect of acetylcholine and atropine on renal secretion of blood-clotting compounds into the bloodstream].
Experiments with perfusion of the kidneys in situ in cats demonstrated that excretion by the kidneys into the circulation of the coagulation factors and fibrinolytic agents could be regulated. Acetylcholine decreased the release into the circulation of the hemocoagulating agents and of the antiheparin compounds, but increased the discharge of plasminogen activators from the kidneys. Atropine stimulated the release from the kidneys of tromboplastic agents and antiheparin components, but decreased the excretion of antithrombin compounds. Atropine intensified the fibrinolytic activity of the perfusate insignificantly.
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D001779:Blood Coagulation Factors; D002415:Cats; D007668:Kidney / Q000378:metabolism*
D001779:Blood Coagulation Factors; D001285:Atropine; D000109:Acetylcholine
Vliianie atsetilkholina i atropina na vydelenie pochkami gemokoaguliruiushchikh soedineniĭ v krovenosnoe ruslo