title: Tolerance to the increase of striatal homovanillic acid elicited by several anorectic drugs.
abstract: Several anorectic drugs affect dopamine metabolism in the rat striatum, increasing the concentration of homovanillic acid (HVA). However 1- and d-amphetamine and mazindol develop a tolerance to the HVA increase. On the contrary, the effect of fenfluramine and S 992 is not reduced by sub-chronic treatments. Moreover, a cross-tolerance to this biochemical effect develops between amphetamine and mazindol, but pretreatment with fenfluramine or with S 992 does not induce cross-tolerance to amphetamine.
mesh_terms: D000818:Animals; D001067:Appetite Depressants / Q000494:pharmacology*; D003342:Corpus Striatum / Q000378:metabolism*; D004361:Drug Tolerance; D005260:Female; D006719:Homovanillic Acid / Q000378:metabolism*; D010648:Phenylacetates / Q000378:metabolism*; D051381:Rats; D013268:Stimulation, Chemical
chemical_list: D001067:Appetite Depressants; D010648:Phenylacetates; D006719:Homovanillic Acid