title: Single dose response curves of normal cells in situ.
abstract: Analysis of data on the response of normal tissues (skin, lung, spinal cord, intestine, testis) to single and multifractionated irradiation schedules revealed the characteristics of the single dose survival curves of target cells responsible for skin, lung, and spinal cord reactions, and of stem cells of colonic, jejunal, gastric mucosae, and testis exposed in situ to relatively low doses of x- or gamma-rays. The single dose survival curves of these cells seem to be complex (unlike those of cells studied in vitro), that is, simply exponential in the initial portion up to approximately 250 rads, and downward-bending thereafter in a curve which includes one or two linear portions on a semilogarithmic scale.
mesh_terms: D002477:Cells / Q000528:radiation effects*; D003106:Colon / Q000166:cytology; D004307:Dose-Response Relationship, Radiation; D005753:Gastric Mucosa / Q000166:cytology; D007413:Intestinal Mucosa / Q000166:cytology; D007583:Jejunum / Q000166:cytology; D008168:Lung / Q000166:cytology; D008297:Male; D011832:Radiation Injuries; D012867:Skin / Q000166:cytology; D013116:Spinal Cord / Q000166:cytology; D013270:Stomach / Q000166:cytology; D013737:Testis / Q000166:cytology