Clozapine-induced agranulocytosis: a situation report up to August 1976.
The frequency of agranulocytosis in association with clozapine therapy has been estimated and compared with data reported for phenothiazine-induced agranulocytosis. Apart from the "epidemic" in Finland, where the frequency was 21 times that in other countries, there is no evidence that clozapine-related agranulocytosis is more common than the phenothiazine-related disorder. Furthermore, results are given to show that strict adherence to precautionary measure (e.g. weekly blood counts) reduces the mortality-rate of this condition.
D000380:Agranulocytosis / Q000139:chemically induced* / Q000453:epidemiology / Q000401:mortality; D003024:Clozapine / Q000009:adverse effects*; D003984:Dibenzazepines / Q000009:adverse effects*; D005060:Europe; D005387:Finland; D006801:Humans
D003984:Dibenzazepines; D003024:Clozapine