Pulmonary inactivation of prostaglandin by hypertensive rats.
Lungs of normotensive and genetically hypertensive (GH) albino rats were perfused in stiu with 5 ml/min Krebs solutuion containing 100 ng/ml PGE2 or F2alpha. Inactivation rates of 76,0 ng PGF2 alpha and 146,3 ng PGE2/g dry wt. lung/min were recorded for GH rats. Values for normotensive controls were 191,2 and 226,1 ng/g/min.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003864:Depression, Chemical; D006321:Heart / Q000187:drug effects; D006973:Hypertension / Q000503:physiopathology*; D008168:Lung / Q000378:metabolism*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010477:Perfusion; D011458:Prostaglandins E / Q000378:metabolism*; D011460:Prostaglandins F / Q000378:metabolism*; D011465:Prostaglandins, Synthetic / Q000378:metabolism; D051381:Rats
D011458:Prostaglandins E; D011460:Prostaglandins F; D011465:Prostaglandins, Synthetic