title: Collagen breakdown and nitrogen dioxide inhalation.
abstract: Measurements of urinary hydroxylysine glycosides indicate that considerable collagen degradation occurred during the reentry into the earth's atmosphere of the American astronauts of the Apollo-Soyuz mission. Since the crew accidentally inhaled nitrogen dioxide, a recognized pulmonary irritant, and showed clinical and roentgenographic signs of diffuse chemical pneumonitis, it is likely that collagen degradation occurred in the pulmonary parenchyma.
mesh_terms: D003094:Collagen / Q000378:metabolism*; D006027:Glycosides / Q000652:urine*; D006801:Humans; D006901:Hydroxylysine / Q000031:analogs & derivatives* / Q000652:urine; D008168:Lung / Q000378:metabolism; D008171:Lung Diseases / Q000139:chemically induced / Q000652:urine; D008297:Male; D009585:Nitrogen Dioxide / Q000009:adverse effects* / Q000494:pharmacology; D013026:Space Flight
chemical_list: D006027:Glycosides; D006901:Hydroxylysine; D003094:Collagen; D009585:Nitrogen Dioxide