[Mutagenic activity of luminal and pyrazidol].
The mutagenic activity of two psychotropic preparations luminal and pyrazidol was studied. It was shown that luminal is capable of indicing chromosomal aberrations in bone marrow cells of mice as well as dominant lethal mutations in postmeiotic stages of spermiogenesis. This allows one to consider it as genetically dangerous. Pyrazidol did not show any mutagenic activity in the studied test objects. These data must be taken into account when treating individuals who are still in the reproductive period of life.
D000818:Animals; D000928:Antidepressive Agents / Q000009:adverse effects*; D001853:Bone Marrow / Q000187:drug effects / Q000648:ultrastructure; D001854:Bone Marrow Cells; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects*; D005799:Genes, Dominant; D005804:Genes, Lethal; D006824:Hybridization, Genetic; D007211:Indoles / Q000009:adverse effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009153:Mutagens; D010634:Phenobarbital / Q000009:adverse effects*; D011719:Pyrazines / Q000009:adverse effects*; D013094:Spermatozoa / Q000187:drug effects / Q000648:ultrastructure
D000928:Antidepressive Agents; D007211:Indoles; D009153:Mutagens; D011719:Pyrazines; D010634:Phenobarbital
Izuchenie mutagennoĭ aktivnosti liuminala i pirazidola