[Effect of azabutyrone and its analogs on catecholamine metabolism in the brains of rats].
The action of the neuroleptic azabutyrone and its analogues on the accumulation and disappearance of 3H-norepinephrine and 3H-dopamine was studied in test on rats by using 3H-thyrosine, a tagged precursor of catecholamines. Azabutyrone is shown to be capable to speed up the dopamine circulation rate, as well as that of norepinephrine in the brain of rats. By comparison with azabutyrone the diazabicyclodekanyl derivative produces a more marked effect on the criculation of amines. A further "weighting" of the diazabicyclic radical and also substitution of chlorine for the fluorine atom in the para-position of the phenyl ring of butyrophenone leads to weakening of this effect.
D000818:Animals; D001372:Aza Compounds / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism*; D002090:Butyrophenones / Q000494:pharmacology*; D002395:Catecholamines / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D004329:Droperidol / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats
D001372:Aza Compounds; D002090:Butyrophenones; D002395:Catecholamines; D004329:Droperidol; D004298:Dopamine; D009638:Norepinephrine
Vliianie azabutirona i ego analogov na obmen kateholaminov v mozge krys