[Exocrine pancreatic function in rats after treatment with cyclophosphamide (author's transl)].
After a 3- and 8 day administration of cyclophosphamide to rats an approximately dose-dependent decrease in the pancreatic secretion of protein and enzyme activities was demonstrable in vivo under exogenous stimulation with secretin and pancreozymin. The volume of secretion and the electrolyte outputs were found to be slightly lowered. An impairment in enzyme synthesis resulting from cyclophosphamide administration is suggested as the major cause of the observed changes in secretion.
D000818:Animals; D002766:Cholecystokinin / Q000494:pharmacology; D003520:Cyclophosphamide / Q000494:pharmacology*; D008297:Male; D010179:Pancreas / Q000378:metabolism*; D010189:Pancreatic Juice / Q000378:metabolism; D014176:Protein Biosynthesis; D051381:Rats; D012633:Secretin / Q000494:pharmacology
D012633:Secretin; D003520:Cyclophosphamide; D002766:Cholecystokinin
Die exocrine Pankreasfunktion der Ratte nach Behandlung mit Cyclophosphamid