Study of the coefficient of glucose assimilation during muscular exercise in diabetic adolescents deprived of insulin.
In six insulin deprived adolescent diabetics, the influence of muscular effort equal to 50% of the VO2 max on the coefficient of glucose assimilation was evaluated. During an IVTT the coefficient of glucose assimilation at rest was (0.59). 10(-2) +/- 0.14 and it did not increase during physical activity. A minimal concentration of insulin is apparently indispensable to increase glucose utilisation during muscular effort. At higher concentrations other factors probably intervene to enhance glucose assimilation.
D000293:Adolescent; D001786:Blood Glucose / Q000378:metabolism; D002648:Child; D003920:Diabetes Mellitus / Q000188:drug therapy; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism* / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D005951:Glucose Tolerance Test; D006029:Glycosuria; D006801:Humans; D007328:Insulin / Q000627:therapeutic use*; D007657:Ketone Bodies / Q000652:urine; D008297:Male; D009132:Muscles / Q000502:physiology*; D005082:Physical Exertion
D001786:Blood Glucose; D007328:Insulin; D007657:Ketone Bodies