Ultrastructure of neurofibrillary tangles in progressive supranuclear palsy.
Ultrastructure of neurofibrillary tangles was investigated on the subcortical neurons of an autopsy case of progressive supranuclear palsy. The patient was a 64-year-old female and suffered from her illness for 9 years. Two kinds of ultrastructure were observed in the subcortical neurofibrillary tangles, i.e. that 150 A straight tubules and the 220 A twisted tubules. They appeared separately in each neuron and a transition between these two structures could not be remarked. Besides, a few particles with a paracrystalline hexagonal structure were observed in some subcortical neurons.
D001921:Brain / Q000648:ultrastructure*; D003711:Demyelinating Diseases / Q000473:pathology*; D005260:Female; D006801:Humans; D008854:Microscopy, Electron; D008875:Middle Aged; D009454:Neurofibrils / Q000648:ultrastructure*; D009886:Ophthalmoplegia / Q000473:pathology*; D013577:Syndrome