The influence of N-methyl-N-beta-chloroethyl hydrazines on the mitotic index of Ehrlich ascites tumor cells and the leukopoiesis of the mouse.
The cytostatic activity of N'-methyl-N'-beta-chloroethylbenzaldehyd hydrazone (B1) is at least equal to that of procarbazine when its effect is tested with the Ehrlich ascites tumor cells of the mouse and the Yoshida sarcoma of the rat. B1 causes a slighter decrease of mitotic cells and no shift from prophase to metaphase. These results suggest that the cytostatic effect of B1 is due to interference with cell metabolism or an effect at the cell membrane and not to an effect on cell proliferation. This assumption is supported by a considerable depression of lymphocytes and a minor effect on granulopoiesis, which is especially sensitive towards proliferation toxins. All these findings suggest a different mechanism of action of B1 and procarbazine.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000503:physiopathology*; D003864:Depression, Chemical; D006834:Hydrazines / Q000031:analogs & derivatives / Q000494:pharmacology*; D007958:Leukocyte Count; D007962:Leukocytes / Q000187:drug effects / Q000502:physiology*; D008297:Male; D051379:Mice; D008938:Mitosis / Q000187:drug effects*; D008940:Mitotic Index / Q000187:drug effects*; D011344:Procarbazine / Q000494:pharmacology; D013997:Time Factors
D006834:Hydrazines; D011344:Procarbazine