Effects of diethylstilbestrol on the production of various extracellular products of Staphylococcus aureus.
The synthetic estrogen diethylstilbestrol at a subinhibitory level of 1.75 microng/ml diminished the production of staphylococcal alpha toxin, coagulase, deoxyribonuclease and penicillinase. Thus, the reported host beneficial effects of diethylstilbestrol may be partially related to its retardive action of certain toxins, or enzymes of S. aureus.
D001427:Bacterial Toxins / Q000096:biosynthesis; D003030:Coagulase / Q000096:biosynthesis; D003851:Deoxyribonucleases / Q000096:biosynthesis; D004054:Diethylstilbestrol / Q000494:pharmacology*; D010405:Penicillinase / Q000096:biosynthesis; D013211:Staphylococcus aureus / Q000187:drug effects / Q000378:metabolism*
D001427:Bacterial Toxins; D003030:Coagulase; D004054:Diethylstilbestrol; D003851:Deoxyribonucleases; D010405:Penicillinase