Juvenile parkinsonism treated with levodopa.
We describe three patients with early onset of parkinsonism. Two of these were sisters and showed a reduction in homovanillic acid (HVA), 5-hydroxytryptamine (5-HT), and 5-hydroxyindole acetic acid (5-HIAA) levels in the CSF. In the third patient, parkinsonism developed, which was probably related to chickenpox encephalitis. All three patients responed favorably to levodopa therapy.
D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D004341:Drug Evaluation; D005260:Female; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D007980:Levodopa / Q000627:therapeutic use*; D010300:Parkinson Disease / Q000134:cerebrospinal fluid / Q000188:drug therapy* / Q000235:genetics; D012701:Serotonin / Q000134:cerebrospinal fluid
D012701:Serotonin; D007980:Levodopa; D006897:Hydroxyindoleacetic Acid; D006719:Homovanillic Acid