title: [Penicillamine-induced glomerulonephritis].
abstract: In 6 of 24 courses of a disease a nephrotic syndrome appeared under the application of penicillamine. An acute renal failure with exitus letalis developed under the penicillamine therapy of a scleroderma. In the treatment of a mercurial poisoning by penicillamine the nephrotic syndrome increased to a proteinuria of 50 g/24 hours which receded after discontinuation of the remedy. In one group of patients with chronic pyelonephritis could be demonstrated that penicillamine in a primarily damaged kidney must not lead to a secondary glomerular lesion. These findings led to the conclusion that in the appearance of a proteinuria under penicillamine a strong observation of the renal function is necessary, if a continution of the therapy is given from vital indication.
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced; D005260:Female; D005921:Glomerulonephritis / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008630:Mercury Poisoning / Q000188:drug therapy; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000139:chemically induced; D010396:Penicillamine / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D010396:Penicillamine
vernacular_title: Zum Problem der sogenannten Penizillamin-Glomerulonephritis