Rapid near IR spectrophotometric determination of meprobamate in pharmaceutical preparations.
A rapid near IR spectrophotometric method was developed for determining meprobamate in tablets, sustained-release capsules, suspensions, and injectables. The absorbance of a chloroform solution of the drug is obtained at about 1.96 mum for quantitation. Assay of nine commercial products from four different manufacturers gave results ranging from 97 to 104% of label claim. Coefficients of variation of 0.7 and 1.3% were obtained on the tablets and a sustained-release product, respectively.
D002214:Capsules / Q000032:analysis; D003692:Delayed-Action Preparations / Q000032:analysis; D007267:Injections; D008620:Meprobamate / Q000032:analysis*; D012996:Solutions / Q000032:analysis; D013055:Spectrophotometry, Infrared; D013535:Suspensions / Q000032:analysis; D013607:Tablets / Q000032:analysis
D002214:Capsules; D003692:Delayed-Action Preparations; D012996:Solutions; D013535:Suspensions; D013607:Tablets; D008620:Meprobamate