title: Effect of atropine and methiamide on vagally induced gastric acid secretion and gastrin release in anesthetized cats.
abstract: Gastrin release and HCl secretion was induced by electrical vagal stimulation in anesthetized cats. Both atropine (0.1-0.3 mg/kg) and methiamide (4-20 mg/kg) inhibited the HCl secretion (by approximately 60 and approximately 80 %). On the other hand, neither atropine (0.2-2 mg/kg) nor methiamide (20 mg/kg) inhibited the vagally induced gastrin release. Possible explanations of the atropine resistance of the vagal gastrin release mechanism are discussed.
mesh_terms: D000768:Anesthesia, General; D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D002415:Cats; D004558:Electric Stimulation; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D005755:Gastrins / Q000378:metabolism*; D008785:Metiamide / Q000494:pharmacology*; D012636:Secretory Rate / Q000187:drug effects; D013890:Thiourea / Q000031:analogs & derivatives*; D013997:Time Factors; D014630:Vagus Nerve / Q000502:physiology
chemical_list: D005755:Gastrins; D008785:Metiamide; D001285:Atropine; D013890:Thiourea