[Radioimmunoassay for human plasma 8-arginine-vasopressin (author's transl)].
The authors have developed a radioimmunoassay for human plasma vasopressin (AVP) which permits the estimation of antidiuretic hormon (ADH) levels as low as 0,8 pg/ml. The average plasma level of AVP after overnight water restriction was found to be 14,3 pg/ml (sd = 4,4 pg/ml) in normal subjects. They provoked a hypersecretion of ADH by the intravenous injection of 1-2 mg of nicotine. In 11 volunteer normal subjects this stimulation by nicotine provoked ADH hypersecretion which reached a maximum between 2nd and 15th minutes after injection. In 3 cases of diabetes insipidus, nicotine injection did not induce ADH hypersecretion; in 1 case of potomania this response was weak; in 2 cases of syndrome of inappropriate ADH secretion, AVP plasma levels were elevated and the response after nicotine stimulation was exaggerated.
D001127:Arginine Vasopressin / Q000097:blood*; D001769:Blood; D003919:Diabetes Insipidus / Q000097:blood; D006729:Hormones, Ectopic; D006801:Humans; D007010:Hyponatremia / Q000097:blood; D009538:Nicotine / Q000494:pharmacology*; D009994:Osmolar Concentration; D011604:Psychoses, Alcoholic / Q000097:blood; D011863:Radioimmunoassay; D014667:Vasopressins / Q000031:analogs & derivatives* / Q000378:metabolism
D006729:Hormones, Ectopic; D014667:Vasopressins; D001127:Arginine Vasopressin; D009538:Nicotine
Dosages plasmatiques radioimmunologiques de la 8-arginine vasopressine. Réponse à la stimulation par la nicotine