title: The effect of 15 (R) 15 methyl prostaglandin E2 on gastric acid secretion in duodenal ulcer patients.
abstract: The effect of synthetic analogue 15 (R) 15 methyl PGE2 on basal and pentagastrin stimulated maximal acid output in 24 duodenal ulcer patients has been studied. The prostagoandin analogue in a single oral dose of 150 mug reduced both basal and maximum output. Basal acid output fell from a mean control value of 5.9 +/- 1.5 mEq/hr to 2.1 +/- 0.6 mEq/hr (p less than 0.05) and maximum acid output from 32.1 +/- 1.6 mEq/hr to 20.6 mEq/hr (p less than 0.001). The volume of gastric secretion did not alter significantly in the basal state but fell significantly in the maximally stimulated state after prostaglandin administration.
mesh_terms: D000293:Adolescent; D000328:Adult; D004357:Drug Synergism; D004381:Duodenal Ulcer / Q000503:physiopathology*; D005260:Female; D005745:Gastric Acidity Determination; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010418:Pentagastrin / Q000494:pharmacology; D011458:Prostaglandins E / Q000494:pharmacology*; D012636:Secretory Rate / Q000187:drug effects
chemical_list: D011458:Prostaglandins E; D010418:Pentagastrin