Cardiohemodynamic effects of SK&F 24260, D 600, diltiazem, dilazep, and trimetazidine in the dog.
The cardiohemodynamic effects of a hypotensive agent, SK&F 24260, and coronary vasodilators, diltiazem, dilazep, and trimetazidine, and D 600 were studied in anesthetized open-chest dogs. The systemic blood pressure, cardiac output (pulmonary arterial flow), venous return (sum of the inferior and superior caval flow) right atrial pressure and heart rate were measured. All 5 drugs decreased the systemic blood pressure and heart rate and increased the right atrial pressure. The venous return and the cardiac output were reduced by higher doses of all the 5 drugs. However, SK&F 24260 in a wide range of doses greatly and diltiazem slightly but clearly increased the venous return and cardiac output. It appears that SK&F 24260 afects predominantly blood vessels whereas the other drugs affect rather the heart to produce a negative inotropic action.
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D004109:Dilazep / Q000494:pharmacology; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D005711:Gallopamil / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D006352:Heart Ventricles; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D011652:Pulmonary Circulation / Q000187:drug effects; D014292:Trimetazidine / Q000494:pharmacology; D014665:Vasodilator Agents / Q000494:pharmacology*
D000959:Antihypertensive Agents; D014665:Vasodilator Agents; D005711:Gallopamil; D004109:Dilazep; D014292:Trimetazidine