title: [Serotonin metabolism in children with different forms of oligophrenia].
abstract: The authors examined the serotonin and 5-oxyindolacetic acid content in the blood plasma and diurnal urine excretion of 5 OIAA of 37 children from 7--12 years of age with sthenic and asthenic forms of mental retardation. It was possible to show an increase of the initial serotonin and 5-OIAA level in the blood plasma of patients with the asthenic variant. In a prolonged loading with reserpine there was a disturbance of the corresponding adaptive mechanisms. It is assumed that the serotoninergic brain structures may be involved in the pathogenesis and formation of the clinical forms of oligophrenia.
mesh_terms: D002648:Child; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism*; D008607:Intellectual Disability / Q000378:metabolism*; D012110:Reserpine; D012701:Serotonin / Q000378:metabolism*
chemical_list: D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D012110:Reserpine
vernacular_title: Osobennosti obmena serotonia pri raznykh formakh oligofrenii u deteĭ