Simultaneous determination of anticonvulsant drugs by gas-liquid chromatography.
A quantitative gas-liquid chromatographic method for the determination of blood levels of ethosuximide, phenobarbitone, primidone and diphenylhydantoin is described. All four compounds are determined using 1 ml of serum. A simple, direct extraction technique is employed. Ethosuximide is analysed without derivatization. Subsequent flash alkylation with trimethylanilinium hydroxide allows the simultaneous determination of phenobarbitone, primidone, and diphenylhydantoin.
D000927:Anticonvulsants / Q000097:blood*; D002849:Chromatography, Gas; D005013:Ethosuximide / Q000097:blood; D006801:Humans; D008722:Methods; D010634:Phenobarbital / Q000097:blood; D010672:Phenytoin / Q000097:blood; D011324:Primidone / Q000097:blood
D000927:Anticonvulsants; D011324:Primidone; D005013:Ethosuximide; D010672:Phenytoin; D010634:Phenobarbital