The effect of 25-hydroxy vitamin D3 in the osteomalacia of chronic renal failure.
1. Five patients with the osteomalacia of chronic renal failure were given 50--100 nmol of 25-hydroxy vitamin D3 intravenously per day for 24--28 days. 2. In all five patients, during administration of 25-hydroxy vitamin D3 there was a substantial rise in the plasma concentration of 25-hydroxy vitamin D from initially abnormally low values. 3. Significant improvement in bone mineralization, intestinal calcium absorption and muscle strength occurred in the three patients with the greatest rise in plasma 25-hydroxy vitamin D.
D000368:Aged; D002113:Calcification, Physiologic; D002118:Calcium / Q000378:metabolism; D005260:Female; D006801:Humans; D006887:Hydroxycholecalciferols / Q000627:therapeutic use*; D007676:Kidney Failure, Chronic / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010018:Osteomalacia / Q000188:drug therapy* / Q000209:etiology; D010758:Phosphorus / Q000097:blood
D006887:Hydroxycholecalciferols; D010758:Phosphorus; D002118:Calcium