The use of serial determination of blood serum glycoproteins for indirect evidence of the sensitivity and resistance of malignant tumor cells to clinical chemotherapy.
Sialic acid and mucoprotein tyrosine (MPT) as two important and sensitive indicators of blood serum glycoprotein changes were used for the dynamic follow up of the tumor growth in humans. Their determination was performed before and during chemotherapy with the aim to evaluate indirectly the sensitivity or resistance of malignant cell to the clinical chemotherapy. A total amount of 16 cases with gynecological malignancies was investigated. According to the results of the laborabory findings the patients were divided into three groups: a) with decreased values after chemotherapy, b) with no changes or increased values, c) uncertain results. The laboratory findings corresponded well with the clinical course of the disease.
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D009088:Mucoproteins / Q000097:blood; D009369:Neoplasms / Q000097:blood / Q000188:drug therapy*; D012794:Sialic Acids / Q000097:blood
D000970:Antineoplastic Agents; D006023:Glycoproteins; D009088:Mucoproteins; D012794:Sialic Acids; D003520:Cyclophosphamide