[Comparative effects of pentagastrin and caerulein on the insulin secretion in the anesthesized dog].
The insulin-secretory effect of pentagastrin (5-G) and caerulein (CRL) was studied comparatively in the anesthesized dog. Both peptides, infused into the femoral vein for 30 minutes in doses of 0.20 microng/kg/min and 0.035 microng/kg/min respectively, caused a significant increase in plasma IRI without simultaneously modifying blood glucose. The insulin-secretory activity is however transitory for both, being a little more prolonged for CRL. On a molar basis the latter is almost 50 times more active than 5-G. The mechanism of the beta-cytotropic action of CRL and the different behaviour of the two peptides is discussed.
D000758:Anesthesia; D000818:Animals; D002108:Ceruletide / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D008297:Male; D010179:Pancreas / Q000502:physiology; D010418:Pentagastrin / Q000494:pharmacology*; D012636:Secretory Rate / Q000187:drug effects
D007328:Insulin; D002108:Ceruletide; D010418:Pentagastrin
Effetti comparativi della pentagastrina e della ceruleina sulla secrezione insulinica nel cane anestetizzato