Coagulation factor XIIa (activated Hageman factor) inhibitor from adult Schistosoma mansoni.
An inhibitory activity for the contact phase of the intrinsic coagulation pathway was demonstrated in an extract of adult Schistosoma mansoni. Inhibition is apparently specific for the enzymatic activation of Factor XI (pre-PTA) by Factor XIIa (activated Hageman factor). This phenomenon offers an explanation for the schistosomal evasive mechanism of the host contact hemostatic defense system.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D001780:Blood Coagulation Tests; D004789:Enzyme Activation; D005170:Factor X; D005172:Factor XI; D005174:Factor XII / Q000037:antagonists & inhibitors*; D005260:Female; D006487:Hemostasis; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D012550:Schistosoma mansoni
D005170:Factor X; D005174:Factor XII; D005172:Factor XI