title: [New analogs of papaverine: synthesis, pharmacological and conformational study of benzyl-4-isoquinolines substituted in the 1 or 3 position].
abstract: The synthesis of p-chlorobenzyl-4-isoquinolines variously substituted in the 1 and 3 positions by condensation in an acid medium of the diethyl acetal of a substituted N-veratrylaminoacetaldehyde with p-chlorobenzaldehyde is described. Pharmacological and conformational tests have been carried in comparison with papaverine and p-chlorobenzyl-4-isoquinoline. The basicities of these derivatives have been measured and compared.
mesh_terms: D000818:Animals; D006168:Guinea Pigs; D007546:Isoquinolines / Q000138:chemical synthesis / Q000627:therapeutic use; D008297:Male; D051379:Mice; D009120:Muscle Cramp / Q000188:drug therapy; D010208:Papaverine / Q000031:analogs & derivatives*; D010276:Parasympatholytics / Q000138:chemical synthesis
chemical_list: D007546:Isoquinolines; D010276:Parasympatholytics; D010208:Papaverine
vernacular_title: Nouveaux analogues de la papaverine: synthese, etude pharmacologique et conformationnelle de benzyl-4 isoquinoleines substituees en 1 ou en 3