title: Interactions of intestinal lymph flow and secretion.
abstract: The relationship between lymph flow and intestinal secretion was studied in an isolated, vascularly perfused cat ileal preparation in which secretion was caused by three different means: 1) plasma dilution from a constant infusion of Tyrode solution (2.5 ml/min per kg), 2) elevation of intestinal venous pressure to 30 mmHg, and 3) exposure to cholera toxin. In the plasma-dilution group, lymph flow attained a peak value of 38 times control at 60-90 min following the onset of the infusion, after which time lymph flow progressively decreased. Concomitant to the rapid decrease in lymph flow was a rapid increase in intestinal secretion (filtration secretion). A similar pattern, i.e., a rapid increase in lymph flow followed by a progressive decrease in lymph flow and concomitant increase in filtration secretion, was observed in the venous hypertension group; however, peak lymph flow (20 X control) was observed within 10 min of the pertubation. No correlation between the onset of intestinal secretion and a decline in lymph flow was observed in the cholera toxin group.
mesh_terms: D000818:Animals; D001794:Blood Pressure; D002415:Cats; D003102:Colloids / Q000097:blood; D005260:Female; D006400:Hematocrit; D007082:Ileum / Q000378:metabolism / Q000502:physiology; D066298:In Vitro Techniques; D007413:Intestinal Mucosa / Q000378:metabolism*; D008196:Lymph / Q000502:physiology*; D009997:Osmotic Pressure; D012212:Rheology; D014118:Toxins, Biological / Q000494:pharmacology; D014734:Vibrio cholerae
chemical_list: D003102:Colloids; D014118:Toxins, Biological