Studies on the pathogenesis of experimental autoimmune renal tubulointerstitial disease in guinea-pigs. IV. failure to inhibit mononuclear cell accumulation with niridazole.
Niridazole is a potent inhibitor of certain expressions of delayed-type hypersensitivity; however, its effect and specificity on other immunologically induced mononuclear cell infiltrates has not been determined. We therefore tested this drug in a model of auto-antibody-induced renal tubulointerstitial disease (RTD), which is characterized by the accumulation of lymphocytes and macrophages in the cortical interstitium. Niridazole-treated (100 mg/kg) and untreated guineapigs were injected with potent anti-tubular basement membrane serum from donors with RTD. Drug treatment was repeated 2-3 times during the course of 10 days. The characteristic renal lesions were found in both groups. However, a single dose of niridazole inhibited skin reactivity in tuberculin sensitive guinea-pigs for at least 8 days. These findings further support the contention that immunologic tissue injury in RTD does not involve mechanisms of delayed-type hypersensitivity.
D000818:Animals; D001323:Autoantibodies; D001485:Basement Membrane / Q000276:immunology; D002465:Cell Movement / Q000187:drug effects; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000188:drug therapy; D007106:Immune Sera; D007674:Kidney Diseases / Q000209:etiology / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D009560:Niridazole / Q000494:pharmacology*
D001323:Autoantibodies; D007106:Immune Sera; D009560:Niridazole