Metabolism of exogenous single stranded DNA in normal and NZB/W mice.
Metabolism of ss-DNA in Swiss Webster mice and NZB/W mice was studied. The delay in intra-hepatic catabolism of ssDNA in old NZB/W female mice seems to correlate with the presence of increased anti-DNA antibodies; similar to effects produced in Swiss Webster mice that have been pretreated with a small dose of carbon black. Neither impairment in the phagocytic ability nor a decrease in DNase activity are found in the mice who are relatively unable to metabolize ssDNA. These observations are discussed in relation to possible pathogenesis in NZB/W mice.
D000818:Animals; D000906:Antibodies; D002244:Carbon; D004277:DNA, Single-Stranded / Q000276:immunology / Q000378:metabolism*; D003851:Deoxyribonucleases / Q000378:metabolism; D005260:Female; D007728:Kupffer Cells / Q000201:enzymology; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D008814:Mice, Inbred NZB / Q000378:metabolism*; D010587:Phagocytosis
D000906:Antibodies; D004277:DNA, Single-Stranded; D002244:Carbon; D003851:Deoxyribonucleases