title: Short-term toxicity of strontium chloride in rats.
abstract: A range-finding experiment with strontium chloride hexahydrate (0, 3, 30, 300 and 3000 ppm in the diet) and subsequently a 90-day test with the same compound at dose levels of 0, 75, 300, 1200 and 4800 ppm in a semipurified diet was carried out with SPF-derived Wistar-rats. The diet contained adequate levels of Ca, Mg, P and Vit.D3. Growth, food intake, behaviour and mortality were measured, extensive haematology and clinical biochemistry carried out, organ weights determined, X-ray photographs of the bones taken and complete histopathological examination was performed. In addition Sr-content of blood, bone and muscles was determined. Thyroid weights were significantly increased in the males of the 1200 and 4800 ppm group. Histological evidence for increased thyroid activity was noticed in the males of the 4800 ppm group. Pituitary weights were significantly decreased in the females of the 300 ppm and 4800 ppm group, but not of the 1200 ppm group. A histologically confirmed glycogen depletion of the liver was noted biochemically in the highest dose group (4800 ppm). Sr-content in bone was increased at all dose levels having a constant level from 4 weeks onwards, thus indicating that a no effect level cannot be established. If the increased Sr-concentration in the bone can be considered a non-toxic effect, the non-toxic effect level appears to be 309 ppm.
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001842:Bone and Bones / Q000032:analysis; D002118:Calcium / Q000032:analysis; D005260:Female; D006128:Growth / Q000187:drug effects*; D008099:Liver / Q000032:analysis / Q000187:drug effects; D008274:Magnesium / Q000032:analysis; D008297:Male; D009132:Muscles / Q000032:analysis; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D012737:Sex Factors; D013324:Strontium / Q000032:analysis / Q000097:blood / Q000633:toxicity*; D013961:Thyroid Gland / Q000032:analysis / Q000187:drug effects; D013997:Time Factors
chemical_list: D008274:Magnesium; D002118:Calcium; D013324:Strontium