The effect of a protein-free diet, a sugar diet and of carbon tetrachloride administration on the toxicity and rate of metabolism of dimethylnitrosamine in different rat strains.
A Porton and a hooded rat strain showed a raised LD50 for dimethylnitrosamine (DMN) when pre-conditioned on a protein-free and/or a sugar diet. Little or no such differential toxicity between normal and diet-fed animals was found for rats of the Wistar, BDIX and CFY strains. Pre-treatment with CCl4 did not alter significantly the toxicity of DMN in the Wistar strain. All 5 rat strains treated by diet or CCl4 administration metabolized DMN at a very much slower rate than did the controls, the rates for the different strains being quantitatively similar. It is concluded that the toxicity of DMN is not necessarily related to its rate of metabolism and that the effect of diet or CCl4 treatment of DMN toxicity is dependent on the strain of rat used.
D000818:Animals; D002251:Carbon Tetrachloride / Q000494:pharmacology*; D004040:Dietary Carbohydrates / Q000378:metabolism*; D004128:Dimethylnitrosamine / Q000378:metabolism / Q000633:toxicity; D009602:Nitrosamines / Q000378:metabolism; D011488:Protein Deficiency; D051381:Rats; D011919:Rats, Inbred Strains
D004040:Dietary Carbohydrates; D009602:Nitrosamines; D002251:Carbon Tetrachloride; D004128:Dimethylnitrosamine