The effect of HLA antibodies on platelet aggregation.
Twelve different HLA antisera, detecting antigens of both A and B series and the superspecificities w4 and w6, were tested for platelet-aggregating activity in 75 antiserum-platelet combinations. The correlation between the HLA specificities of the antisera and the aggregating effect on platelets carrying the corresponding antigens was significant (P = 0.011). Because the platelet aggregation test is being used for screening of circulating immune complexes, falsely positive reactions caused by HLA antibodies must be eliminated by adequate control experiments.
D000918:Antibody Specificity; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D006801:Humans; D007106:Immune Sera; D010641:Phenotype; D010974:Platelet Aggregation
D006680:HLA Antigens; D006649:Histocompatibility Antigens; D007106:Immune Sera