Tumor cell locomotion--a factor in metastasis formation? Influence of cytochalasin B on a tumor dissemination pattern.
The influence of Cytochalasin B (CB) on TA3 ascites tumor cells was studied in vivo in order to assess whether CB-induced cell paralysis would affect the transplanation behavior of the cells and in particular tumor distribution after IV cell infusion ("experimental metastases"). Tumor cell pre-treatment with CB (1 mug/ml) did not alter the SC or IV transplantability of TA3 cells. Pre-treatment with 10 mug/ml CB, in contrast, consistently increased the incidence and number of extra-pulmonary tumor takes from IV transfused cells. The amount of pulmonary tumors was not significantly altered. SC transplantability was not affected by 10 mug/ml CB. The importance of cell mobility and cell surface topography for tumor cell nidation in vessels is discussed.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000473:pathology; D003571:Cytochalasin B / Q000008:administration & dosage / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation; D009360:Neoplastic Cells, Circulating; D014185:Transplantation, Isogeneic
D003571:Cytochalasin B