A human IgA myeloma protein interacting with staphylococcal alpha-toxin and protein A.
High anti-staphylolysin activity was found in the serum from a patient with multiple myeloma. The activity was confined to the monoclonal IgA protein and was dependent on an intact Fc part of the molecule. An Fc-dependent interaction with protein A was also demonstrated. In addition, a part of the monoclonal IgA was found to be complexed with alpha2-macroglobulin. The results imply an unusual Fc-reactivity of the IgA protein.
D000328:Adult; D001426:Bacterial Proteins / Q000378:metabolism; D001427:Bacterial Toxins / Q000378:metabolism*; D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism*; D007141:Immunoglobulin Fc Fragments; D008297:Male; D009101:Multiple Myeloma / Q000276:immunology*; D009194:Myeloma Proteins / Q000378:metabolism*; D013210:Staphylococcus
D001426:Bacterial Proteins; D001427:Bacterial Toxins; D007070:Immunoglobulin A; D007141:Immunoglobulin Fc Fragments; D009194:Myeloma Proteins