Aminophylline bioavailability and the across-time stability of plasma theophylline levels.
Three generic aminophylline products were examined and found to have equivalent bioavailability. Plasma theophylline levels were found to be reproducible in most patients (intraclass r = 0.7). There were some patients who showed wide swings in plasma theophylline levels without signs of toxicity or clinical deterioration.
D000293:Adolescent; D000628:Aminophylline / Q000378:metabolism*; D001249:Asthma / Q000097:blood / Q000188:drug therapy*; D001682:Biological Availability; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D013806:Theophylline / Q000097:blood*
D000628:Aminophylline; D013806:Theophylline