Plasma levels and intestinal absorption of 25-hydroxyvitamin D in patients with small bowel resection.
Plasma levels of 25-hydroxyvitamin D (25-OHD) were found to be significantly reduced in a group of patients with small bowel resection when compared with normal controls. Plasma levels of 25-OHD after an oral dose of 25-hydroxyvitamin D3 (25-ohd3) were also reduced in the patient group. Dietary intake of vitamin D tended to be low in many patients, but seasonal variation of plasma 25-OHD levels indicated normal exposure to sunlight in most of the patients studied. It is suggested that these studies provide some evidence for malabsorption of 25-OHD after small bowel resection, which, it is postulated, may be due to interruption of the enterohepatic circulation of bile acids and of 25-OHD. These factors may contribute towards the low plasma levels of 25-OHD found in the patient group.
D000328:Adult; D000368:Aged; D004032:Diet; D005260:Female; D006801:Humans; D006887:Hydroxycholecalciferols / Q000097:blood / Q000378:metabolism*; D007408:Intestinal Absorption; D007421:Intestine, Small / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D012621:Seasons; D014807:Vitamin D
D006887:Hydroxycholecalciferols; D014807:Vitamin D