Effect of xanthinol nicotinate treatment on platelet aggregation.
Treatment of 24 male patients with 3 g/day of xanthinol nicotinate did not change the in vitro measurements of ADP-induced platelet aggregation but produced a marked inhibition of collagen-induced platelet aggregation. This effect may be connected with the drug-induced depression of the ATP level in platelet-rich plasma. Changes in the platelets in the patients' blood or in the lipid composition and the concentration of uric acid in their serum were ruled out as reasons for the decrease of the collagen-induced aggregation. The activity of the three serum enzymes y-GT, GOT, and GPT and the concentration of the blood sugar did not change.
D000227:Adenine Nucleotides / Q000097:blood; D000244:Adenosine Diphosphate; D000368:Aged; D001772:Blood Cell Count; D001792:Blood Platelets; D003094:Collagen; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009539:Nicotinic Acids / Q000097:blood; D010974:Platelet Aggregation / Q000187:drug effects*; D013806:Theophylline / Q000031:analogs & derivatives*; D013997:Time Factors; D014971:Xanthinol Niacinate / Q000494:pharmacology*
D000227:Adenine Nucleotides; D008055:Lipids; D009539:Nicotinic Acids; D000244:Adenosine Diphosphate; D014971:Xanthinol Niacinate; D003094:Collagen; D013806:Theophylline