Vitamin A in the treatment of menorrhagia.
Hypovitaminosis A was found to be an important cause of menorrhagia, and a statistically significant difference between the fasting serum vitamin A values of healthy controls and patients with menorrhagia was noted. Vitamin A is a co-factor of 3 beta-dehydrogenase in steroidogenesis and deficiencies of this vitamin may result in impaired enzyme activity. The level of endogenous 17 beta-oestradiol appears to be elevated with vitamin A therapy, and menorrhagia was alleviated in more than 92% of patients.
D000293:Adolescent; D000328:Adult; D000568:Amenorrhea / Q000097:blood; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D008110:Liver Extracts / Q000627:therapeutic use; D008595:Menorrhagia / Q000188:drug therapy* / Q000209:etiology; D008875:Middle Aged; D009839:Oligomenorrhea / Q000097:blood / Q000188:drug therapy; D014801:Vitamin A / Q000627:therapeutic use*; D014802:Vitamin A Deficiency / Q000150:complications; D026681:Vitamin B 6 Deficiency / Q000150:complications
D008110:Liver Extracts; D014801:Vitamin A; D004958:Estradiol