title: Polymorphic acetylation of sulphadimidine in normal and uraemic man.
abstract: After oral administration of sulphadimidine (mean dose 3.33 g) to 21 volunteers it was possible to distinguish fast and slow acetylators by calculating the acetylated fraction (%acSDD) in a single serum sample obtained at any time between 1/2-24 h. There was a close correlation between %acSDD in serum and in urine collected from 0-8 h. Two groups of patients with chronic renal failure were studied. Four of the first 8 patients studied would have been designated as slow acetylators from their low %acSDD in 0-8 h urine, but as fast acetylators from their %acSDD in serum 6 h after drug administration. The next 18 patients were given a smaller dose of SDD (2 g) and they showed complete intra-individual correlation between %acSDD in 0-24 h urine and in a serum sample obtained at 24 h. The patients could be divided into 2 sub-groups on the basis of %acSDD in serum and urine, thus demonstrating the ability of this procedure to distinguish fast and slow acetylators, even in advanced chronic renal failure.
mesh_terms: D000107:Acetylation; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000378:metabolism; D007700:Kinetics; D008967:Molecular Biology; D010641:Phenotype; D013418:Sulfamethazine / Q000097:blood / Q000378:metabolism* / Q000652:urine; D013997:Time Factors; D014511:Uremia / Q000209:etiology / Q000378:metabolism*
chemical_list: D013418:Sulfamethazine