Phenytoin toxicity: a fatal case in a dog with hepatitis and jaundice.
Pheyntoin (Epanutin: Parke, Davis) is widely used for the control of chronic convulsive disorders in the dog because it exerts an anti-epileptic effect without causing general depression of the central nervous system. To our knowledge fatal cases of phenytoin sensitivity in the dog have not been reported. A case is described in which hepatitis, jaundice and death followed the administration of the drug.
D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000139:chemically induced* / Q000473:pathology; D004285:Dogs; D007565:Jaundice / Q000139:chemically induced / Q000473:pathology / Q000662:veterinary*; D008099:Liver / Q000473:pathology; D008297:Male; D010672:Phenytoin / Q000009:adverse effects*; D012867:Skin / Q000473:pathology
D010672:Phenytoin