[Cefazolin content in the gall bladder (author's transl)].
The concentration of cefazolin in the bile obtained by means of duodenoscopy was determined and compared with the values published as results of sampling by gall bladder puncture and T drains. The results obtained using this endoscopic procedure accorded with the results in the literature. When 1 g cefazolin was administered intravenously, high biliary levels of this drug with antibacterial activity were achieved. Our preliminary studies show that not only highly-sensitive gram-positive organisms, but also most of the E. coli Klebsiella and indol-negative proteus bacteria were affected when 1 g cefazolin was administered 3-4 times daily. These results will be reported later. Cefazolin (Gramaxin) represents a valuable addition to the chemotherapeutic agents available in combating infections of the gall bladder and the biliary duct system.
D001424:Bacterial Infections / Q000188:drug therapy*; D001646:Bile / Q000032:analysis; D001660:Biliary Tract Diseases / Q000188:drug therapy*; D002437:Cefazolin / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use*; D002511:Cephalosporins / Q000627:therapeutic use*; D004386:Duodenum; D004724:Endoscopy; D006801:Humans; D007263:Infusions, Parenteral
D002511:Cephalosporins; D002437:Cefazolin
Cefazolingehalt in der Galle