Direct demonstration of beta-globin mRNA in homozygous Ferrara betaO-thalassaemia patients.
In cases of betaO-thalassaemia from Ferrara, Italy, the beta-globin gene in transcribed into mRNA but no protein is synthesised. For these cases there is no hybridisation data suggesting a globin gene structural mutation. This again demonstrates the diverse molecular events which may cause this prevalent hereditary disease.
D001803:Blood Transfusion; D001853:Bone Marrow / Q000378:metabolism; D001854:Bone Marrow Cells; D005914:Globins / Q000096:biosynthesis*; D006455:Hemoglobins, Abnormal / Q000096:biosynthesis; D006801:Humans; D009693:Nucleic Acid Hybridization; D012333:RNA, Messenger / Q000097:blood*; D012156:Reticulocytes / Q000378:metabolism; D013789:Thalassemia / Q000097:blood*
D006455:Hemoglobins, Abnormal; D012333:RNA, Messenger; D005914:Globins