Chemotherapy of genital herpes simplex virus type 2 infections of female hamsters.
The antiviral activity of 1-beta-d-arabinofuranosylcytosine (ara-C, cytarabine, Cytosar), 5-iodo-2'-deoxyuridine (IdUrd), 9-beta-d-arabinofuranosyladenine (ara-A), and disodium phosphonoacetate (PAA) have been compared in herpes simplex virus type 2 (HSV-2)-infected primary rabbit kidney cells and in female hamsters with genital HSV-2 infection. In vitro, ara-C and IdUrd were more active than ara-A, and PAA was least active. In female hamsters with genital HSV-2 infection, intravaginal treatment with PAA or ara-A was more effective than either ara-C or IdUrd. PAA was more active than ara-A when treatment was initiated early (1 h) after infection. The activity of PAA was greatly reduced if initiation of treatment was delayed for 24 h. Both PAA and ara-A reduced the virus titers of the vagina and protected hamsters from death when the drugs were given by either the intravaginal or subcutaneous route, with intravaginal treatment being more effective.
D000818:Animals; D002460:Cell Line; D006224:Cricetinae; D003561:Cytarabine / Q000627:therapeutic use*; D005260:Female; D006561:Herpes Simplex / Q000188:drug therapy*; D007065:Idoxuridine / Q000627:therapeutic use*; D063065:Organophosphonates / Q000627:therapeutic use*; D014623:Vaginal Diseases / Q000188:drug therapy*; D014740:Vidarabine / Q000627:therapeutic use*
D063065:Organophosphonates; D003561:Cytarabine; D014740:Vidarabine; D007065:Idoxuridine