Choriocarcinoma in Jamaica.
Fifty-two cases of choriocarcinoma were recorded in the Jamaica Cancer Registry for the parishes of Kingston and St. Andrew, giving an incidence of 1:7,384 live births. This is intermediate between figures reported for Western metropolitan populations and for Far Eastern countries. Clinicopathological studies on 26 cases treated at the University Hospital in Jamaica revealed that 65% followed either normal pregnancy or abortion. Choriocarcinoma following a normal pregnancy or occurring without a previous history of pregnancy carried a poorer prognosis than those with a preceding hydatidiform mole. Many patients had primary neurological manifestations. The overall prognosis was poor due to late presentation with disseminated metastases. Of the 26 patients, 15 died of the disease within two years and only six appeared for a six-year follow-up.
D000293:Adolescent; D000328:Adult; D002822:Choriocarcinoma / Q000453:epidemiology* / Q000401:mortality / Q000628:therapy; D005260:Female; D005833:Genital Neoplasms, Female / Q000453:epidemiology; D006801:Humans; D006828:Hydatidiform Mole / Q000453:epidemiology; D007563:Jamaica; D009362:Neoplasm Metastasis; D009461:Neurologic Manifestations / Q000150:complications; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology; D014594:Uterine Neoplasms / Q000453:epidemiology* / Q000401:mortality / Q000628:therapy