Trimethoprim-sulphamethoxazole in the treatment of cholera. Comparison with tetracycline and chloramphenicol.
67 of the bacteriologically proved adult acute cholera patients have been examined in order to evaluate the efficacy of TM-SMX in comparison with tetracycline and chloramphenicol in the eradication of Vibrio cholerae from stools. Our results demonstrated that all three drugs sterilized the stools of all patients within 3 days with the exception of one case of TM-SMX's group, which had negative culture stools after 4 days. On the basis of our experience it can be emphasized that TM-SMX can support chloramphenicol and tetracycline in the antibacterial treatment of cholera with the advantage that the drug is efficacious with daily administrations.
D000328:Adult; D002701:Chloramphenicol / Q000627:therapeutic use*; D002771:Cholera / Q000188:drug therapy*; D004338:Drug Combinations; D004341:Drug Evaluation; D005243:Feces / Q000382:microbiology; D006801:Humans; D013420:Sulfamethoxazole / Q000627:therapeutic use*; D013752:Tetracycline / Q000627:therapeutic use*; D014295:Trimethoprim / Q000627:therapeutic use*; D014734:Vibrio cholerae / Q000302:isolation & purification
D004338:Drug Combinations; D002701:Chloramphenicol; D014295:Trimethoprim; D013752:Tetracycline; D013420:Sulfamethoxazole