[Premature cutaneous porphyria caused by oral contraceptives (author's transl)].
Four women, aged 23 to 26 years, fell ill with cutaneous hepatic porphyria. All of them had taken oestrogen-contaning oral contraceptives three to eight years before the illness. In one instance there was a time relationship with a progestogen preparation. The clinical and biochemical signs were those of porphyria cutanea tarda, but contrary to this disease there was a shift towards heptacarboxyporphyrin in the uroporphyrin/heptacarboxyporphyrin ratio (thin-layer chromatography, classified according to Doss). This difference and the onset at an early age suggest that the described disease may be called a hormone-induced premature cutaneous porphyria.
D000328:Adult; D000367:Age Factors; D002855:Chromatography, Thin Layer; D003276:Contraceptives, Oral / Q000009:adverse effects*; D005260:Female; D006801:Humans; D011164:Porphyrias / Q000139:chemically induced*; D011166:Porphyrins / Q000032:analysis; D014578:Uroporphyrins / Q000032:analysis
D003276:Contraceptives, Oral; D011166:Porphyrins; D014578:Uroporphyrins
Porphyria cutanea praematura durch hormonelle Kontrazeptiva