NMR determination of trimethoprim and sulfamethoxazole in tablets and powders.
An NMR spectroscopic method for the determination of mixtures of trimethoprim and sulfamethoxazole is described. Spectra are determined in dimethylsulfoxide-d6, containing 1,4-dinitrobenzene as an internal standard. Both synthetic mixtures and commercial formulations were assayed, and the results were compared to those obtained using the BP procedure.
D004338:Drug Combinations; D009682:Magnetic Resonance Spectroscopy; D011208:Powders; D013420:Sulfamethoxazole / Q000032:analysis*; D013607:Tablets; D014295:Trimethoprim / Q000032:analysis*
D004338:Drug Combinations; D011208:Powders; D013607:Tablets; D014295:Trimethoprim; D013420:Sulfamethoxazole