Adenosine diphosphate-induced platelet aggregation in the states of hypercoagulability.
One hundred and seven patients with congestive heart failure, myocardial infarction and arteriosclerotic heart disease were studied by adenosine diphosphate-induced platelet aggregation, fibrinogen levels and ethanol gelation test. Both increases and decreases in platelet aggregation were observed. A significantly high percentage of patients showed a decreased platelet aggregation which was especially marked in the more acute as opposed to the less acute phase. In addition, most patients exhibited a marked shift from abnormal to normal platelet aggregation or vise-versa within a short time period. This pattern of platelet aggregation suggests an active role of platelets in the states of hypercoagulability. The hypercoagulability of these patients was further substantiated by a high percentage of positive ethanol gelation tests and high fibrinogen levels.
D000244:Adenosine Diphosphate / Q000494:pharmacology*; D001161:Arteriosclerosis / Q000097:blood; D001780:Blood Coagulation Tests; D000431:Ethanol; D005340:Fibrinogen / Q000032:analysis; D005782:Gels; D006333:Heart Failure / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000097:blood; D009203:Myocardial Infarction / Q000097:blood; D010974:Platelet Aggregation / Q000187:drug effects*; D013927:Thrombosis / Q000097:blood*
D005782:Gels; D000431:Ethanol; D000244:Adenosine Diphosphate; D005340:Fibrinogen