[Osteopetrosis (Albers-Schönberg disease). I. Clinico-radiological and pathogenetic aspects].
An account is given of recent clinical and radiological findings with respect to Albers-Schönberg disease. Reference is made to its hereditary transmission modality and clinical picture (skeletal lesions and haematological distress), and to its radiological aspects. Suggestions are made with respect to the aetiopathogenesis of disease. Stress is laid on the as yet undefined mechanism of "genotypical condensing dysplasia". The relation between osteopetrosis and thyrocalcitonin is discussed, though no definite conclusions could be drawn from the hormone levels determined in a personal series.
D000328:Adult; D000367:Age Factors; D000368:Aged; D002116:Calcitonin / Q000097:blood; D005260:Female; D005598:Fractures, Spontaneous / Q000209:etiology; D005799:Genes, Dominant; D005808:Genes, Recessive; D006801:Humans; D008297:Male; D008875:Middle Aged; D010022:Osteopetrosis / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000235:genetics; D044469:Racial Groups; D011859:Radiography; D012886:Skull / Q000000981:diagnostic imaging; D013577:Syndrome
D002116:Calcitonin
L'osteopetrosi (malattia di Albers-Schönberg) nota I Aspetti clinico-radiologici e patogenetici