Elucidation of the structure of the antineoplastic agents, 2-formylpyridine and 1-formylisoquinoline thiosemicarbazones.
The geometrical isomers of the antineoplastic agents 2-formylpyridine and 1-formylisoquinoline thiosemicarbazones were synthesized and their structure was studied by spectroscopic methods. It was found that the compounds previously described in the literature and tested for carcinostatic activity were isomers with E configuration which probably contained minor amounts of Z isomers.
D000970:Antineoplastic Agents / Q000138:chemical synthesis; D055598:Chemical Phenomena; D002621:Chemistry; D007546:Isoquinolines / Q000138:chemical synthesis; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D011725:Pyridines / Q000138:chemical synthesis; D013237:Stereoisomerism; D013882:Thiosemicarbazones / Q000138:chemical synthesis
D000970:Antineoplastic Agents; D007546:Isoquinolines; D011725:Pyridines; D013882:Thiosemicarbazones