New studies on placental transfer of fosfomycin.
Passage of fosfomycin across the placental barrier and the dynamics of maternal and fetal levels were determined in a group of ten mothers in active labor. To obtain a series of intrauterine fetal samples the Saling technique was used. There exists a clear relation between the levels reached in the mother and in the fetus and in function of time, as well as between the amount of antibiotic in the fetal blood 90 min after injection, and the weight of the placenta.
D000900:Anti-Bacterial Agents / Q000378:metabolism*; D005260:Female; D005312:Fetal Blood / Q000032:analysis; D005578:Fosfomycin / Q000097:blood / Q000378:metabolism*; D006801:Humans; D008431:Maternal-Fetal Exchange; D009929:Organ Size; D010920:Placenta / Q000033:anatomy & histology; D011247:Pregnancy; D013997:Time Factors
D000900:Anti-Bacterial Agents; D005578:Fosfomycin