The effect of propranolol on hemolysis in patients with an aortic prosthetic valve.
Propranolol was given to five patients with severe hemolytic anemia from arotic prostheses. Red cell survival, lactic dehydrogenase, serum hemoglobin, and 24 hour urine iron values were used to evaluate the severity of hemolysis with and without propranolol treatment. Three patients had a clear decrease in the level of hemolysis with propranolol therapy. One patient developed congestive failure after 6 months on propranolol. The decrease in hemolysis is most likely related to a slower heart rate.
D000743:Anemia, Hemolytic / Q000188:drug therapy / Q000209:etiology; D001021:Aortic Valve / Q000601:surgery; D004905:Erythrocyte Aging / Q000187:drug effects; D006207:Half-Life; D006339:Heart Rate / Q000187:drug effects; D006350:Heart Valve Prosthesis / Q000009:adverse effects; D006454:Hemoglobins / Q000378:metabolism; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D007501:Iron / Q000652:urine; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D011433:Propranolol / Q000494:pharmacology* / Q000627:therapeutic use
D006454:Hemoglobins; D011433:Propranolol; D007501:Iron; D007770:L-Lactate Dehydrogenase