title: Detection of edema associated with myocardial ischemia by computerized tomography in isolated, arrested canine hearts.
abstract: This study was undertaken to determine if computerized tomography (CT scanning) with an EMI cranial scanner could detect edema associated with myocardial ischemia in canine hearts. A localized area of decreased density in the posterior papillary muscle and surrounding myocardium was detected on serial 8 mm CT scan slices of each heart after 60 min of circumflex artery occlusion and 45 min of reflow of blood. The wet/dry weight ratios and previous electron microscope studies of the ischemic posterior papillary muscles revealed edema accumulation. After 1 hour of arterial occlusion and 12 hours of reflow (which produces extensive necrosis and a decrease in the wet/dry ratio) lesions were still discernible but were less consistently as severe. Permanent ligation of the left anterior descending coronary artery and major collateral arteries for 6 hours also resulted in a lesion of decreased density in the distribution of the occluded arteries. Thus, CT scanning can detect, and is a potential means for sequential noninvasive quantitation of myocardial edema associated with ischemia.
mesh_terms: D000818:Animals; D003327:Coronary Disease / Q000150:complications*; D004195:Disease Models, Animal; D004285:Dogs; D004489:Edema, Cardiac / Q000000981:diagnostic imaging* / Q000209:etiology; D005260:Female; D006324:Heart Arrest, Induced; D006333:Heart Failure / Q000000981:diagnostic imaging*; D008297:Male; D010210:Papillary Muscles / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed