The effect of carbidopa administration on urinary sodium excretion in man. Is dopamine an intrarenal natriuretic hormone?
1 Carbidopa, a known inhibitor of the peripheral conversion of dopa to dopamine, was given to six normal volunteers to examine the effect of interference with dopamine synthesis on urinary sodium excretion. 2 On the first day of administration, carbidopa caused a significant fall not only in urinary dopamine excretion (P less than 0.01) but also in urinary sodium excretion (P less than 0.05). 3 A highly significant correlation was also found between mean sodium excretion and mean dopamine excretion in the days prior to and during carbidopa administration (r = 0.617, P less than 0.001; 4 = 0.764, P less than 0.001 respectively). 4 The significance of these findings is discussed and it is proposed that dopamine may be an important intrarenal natriuretic hormone.
D000328:Adult; D002230:Carbidopa / Q000494:pharmacology*; D003404:Creatinine / Q000652:urine; D004298:Dopamine / Q000502:physiology* / Q000652:urine; D005260:Female; D006801:Humans; D006834:Hydrazines / Q000494:pharmacology*; D007668:Kidney / Q000502:physiology*; D008297:Male; D009318:Natriuresis / Q000187:drug effects*; D011188:Potassium / Q000652:urine; D012964:Sodium / Q000652:urine; D013997:Time Factors
D006834:Hydrazines; D012964:Sodium; D003404:Creatinine; D002230:Carbidopa; D011188:Potassium; D004298:Dopamine