Malignant hyperthermia.
The authors report the case of an infant with noncommunicating hydrocephalus, Arnold-Chiari malformation, and a lumbar myelomeningocele, in whom malignant hyperthermia occurred. The genetics and presumed etiology of this unusual problem are reviewed. The management is directed toward establishing effective cooling measures, reversing tissue hypoxia, and correcting respiratory and metabolic acidosis.
D000138:Acidosis / Q000188:drug therapy / Q000209:etiology; D001139:Arnold-Chiari Malformation / Q000601:surgery; D001639:Bicarbonates / Q000627:therapeutic use; D002557:Cerebrospinal Fluid Shunts; D003080:Cold Temperature; D006801:Humans; D006849:Hydrocephalus / Q000601:surgery; D007223:Infant; D008297:Male; D008305:Malignant Hyperthermia / Q000209:etiology / Q000628:therapy; D009127:Muscle Rigidity; D010100:Oxygen / Q000627:therapeutic use
D001639:Bicarbonates; D010100:Oxygen