Thromboxane B2 transformed from arachidonic acid in carrageenin-induced granuloma.
A main product (PI) transformed from arachidonic acid in carrageenin-induced granuloma in rats was structurally analysed. PI was converted to a more polar substance by the reduction with sodium borohydride. On the basis of the data on gas chromatography-mass spectrometry, its structure was identified with the hemiacetal derivative of 8-(1-hydroxy-3-oxopropyl)-9,12-heptadecadienoic acid (Thromboxane B2).
D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism*; D002351:Carrageenan; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D006099:Granuloma / Q000139:chemically induced / Q000378:metabolism*; D006880:Hydroxy Acids / Q000032:analysis*; D013058:Mass Spectrometry; D008968:Molecular Conformation; D011714:Pyrans / Q000032:analysis*; D051381:Rats
D001095:Arachidonic Acids; D006880:Hydroxy Acids; D011714:Pyrans; D002351:Carrageenan