title: Clinical investigation of doxorubicin, daunomycin, and 6-thioguanine in normal cats.
abstract: Cats frequently develop a variety of spontaneous hemolymphatic noeplasias. Long-term remissions in the nonlymphatic leukemic cat are difficult to obtain; therefore, more successful chemotherapeutic agents are sought for disease control. The purpose in the present study is to describe the clinical investigation of 3 antineoplastic drugs given to 23 normal cats. The cats tolerated doxorubican given at the dose level of 30 mg/m2 of body surface area once every 3 weeks; daunomycin, 15 to 30 mg/m2 once every 3 weeks; and 6-thioguanine, 25 mg/m2 for 5 days every 20 to 30 days.
mesh_terms: D000505:Alopecia / Q000139:chemically induced / Q000662:veterinary; D000818:Animals; D002371:Cat Diseases / Q000097:blood / Q000139:chemically induced*; D002415:Cats / Q000097:blood; D003630:Daunorubicin / Q000633:toxicity*; D004317:Doxorubicin / Q000633:toxicity*; D005260:Female; D007958:Leukocyte Count; D007970:Leukopenia / Q000139:chemically induced / Q000662:veterinary; D008297:Male; D013866:Thioguanine / Q000633:toxicity*; D013921:Thrombocytopenia / Q000139:chemically induced / Q000662:veterinary
chemical_list: D004317:Doxorubicin; D013866:Thioguanine; D003630:Daunorubicin