The effect of water-soluble chemicals on the growth and mitosis of primary newborn rat kidney cells in culture.
Mass cultures of primary rat kidney cells were exposed briefly to aqueous solutions of 20 chemicals and their subsequent growth rate and mitotic activity measured. Proximate carcinogens, and some chemicals with a defined inhibitory action biochemically, depressed the growth and division of the cultures. Non-carcinogenic compounds and precarcinogens did not interfere with the subsequent growth rate and mitotic activity of the cultures. It is suggested that the possession of growth inhibitory properties could give an indication of the carcinogenic activity of a chemical on a short-term basis.
D000818:Animals; D000831:Animals, Newborn; D002273:Carcinogens / Q000494:pharmacology*; D002478:Cells, Cultured / Q000187:drug effects*; D003470:Culture Media; D005347:Fibroblasts / Q000254:growth & development; D007668:Kidney / Q000166:cytology; D008938:Mitosis / Q000187:drug effects*; D051381:Rats; D012995:Solubility; D013997:Time Factors
D002273:Carcinogens; D003470:Culture Media