Plastic flow during compression of directly compressible fillers and its effect on tablet strength.
The effects of the duration of the overall compression cycle and of the duration of the maximum compressive force on tablet strength were studied using an instrumented rotary tablet press. Various direct compression fillers were evaluated. Increasing the overall compression cycle duration to 10 sec resulted in significantly greater tablet tensile strengths with microcrystalline cellulose and compressible starch fillers but not with lactose or compressible sugar. Increasing the duration of the maximum compressive force to 20 sec significantly increased the tensile strength in all cases, but microcrystalline cellulose and compressible starch tablets were affected more than lactose or sugar tablets. The maximum compressive force decayed with time for all fillers but at a greater rate with microcrystalline cellulose and compressible starch. This behavior was attributed to differences in the extent of plastic flow. The decay curves were analyzed using the Maxwell model.
D002130:Calcium Phosphates; D002241:Carbohydrates; D002482:Cellulose; D002626:Chemistry, Pharmaceutical; D005079:Excipients; D007785:Lactose; D008433:Mathematics; D011312:Pressure; D013213:Starch; D013607:Tablets; D013718:Tensile Strength; D013997:Time Factors
D002130:Calcium Phosphates; D002241:Carbohydrates; D005079:Excipients; D013607:Tablets; D002482:Cellulose; D013213:Starch; D007785:Lactose