title: Angel's Trumpet psychosis: a central nervous system anticholinergic syndrome.
abstract: The authors warn physicians that intoxication by Angel's Trumpet (Datura sauveolens) is becoming more frequent due to its use by adolescents and young adults as a legal, readily available hallucinogen. Ingestion of Angel's Trumpet flowers or a tea brewed from them results in an alkaloid-induced central nervous system anticholinergic syndrome characterized by symptoms such as fever, delirium, hallucinations, agitation, and persistent memory disturbances. Severe intoxication may cause flaccid paralysis, convulsions, and death. Treatment with intravenous physostigmine reverses the toxic effects of Angel's Trumpet.
mesh_terms: D000109:Acetylcholine / Q000037:antagonists & inhibitors; D000293:Adolescent; D001285:Atropine / Q000032:analysis; D002490:Central Nervous System / Q000187:drug effects*; D003693:Delirium / Q000139:chemically induced; D006212:Hallucinations / Q000139:chemically induced; D006213:Hallucinogens; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D010243:Paralysis / Q000139:chemically induced; D010830:Physostigmine / Q000008:administration & dosage / Q000627:therapeutic use; D010939:Plant Poisoning / Q000188:drug therapy; D010947:Plants, Toxic / Q000032:analysis; D011605:Psychoses, Substance-Induced / Q000209:etiology*; D012601:Scopolamine / Q000032:analysis; D013997:Time Factors
chemical_list: D006213:Hallucinogens; D001285:Atropine; D010830:Physostigmine; D012601:Scopolamine; D000109:Acetylcholine