title: Neutropenia induced by systemic infusion of chemotactic factors.
abstract: Autologous plasma, when exposed to complement-activating agents that generate leukotactic activity, induces transient neutropenia after infusion into rabbits. Trypsinized human C5 as well as the chemotactic fragment isolated from zymosan-activated human serum also induces transient neutropenia in rabbits, as do chemotactically active synthetic tripeptides. In each instance the neutropenia-inducing activity parallels the chemotactic activity. Thus, neutropenia-inducing activity and chemotactic activity seem to be related physiologic responses of neutrophils. In vivo margination and/or agglutination of leukocytes may underlie this phenomenon of neutropenia.
mesh_terms: D000380:Agranulocytosis / Q000209:etiology*; D000818:Animals; D000906:Antibodies; D002634:Chemotaxis, Leukocyte; D003182:Complement C5; D007263:Infusions, Parenteral; D007962:Leukocytes / Q000276:immunology; D009503:Neutropenia / Q000209:etiology* / Q000276:immunology; D009504:Neutrophils / Q000276:immunology; D011817:Rabbits; D012910:Snake Venoms / Q000276:immunology
chemical_list: D000906:Antibodies; D003182:Complement C5; D012910:Snake Venoms