Prostaglandins in chronic cholecystitis.
Prostaglandin-like material was extracted from the mucosa and muscle wall of chronically inflamed human gallbladders. Bioassays showed that "synthesised" levels were 3-5 times corresponding "basal" levels, indicating that both mucosa and muscle wall can synthesise PG-like substances, and that indomethacin (10 mug/ml) inhibited this synthesis. Mucosal PG levels were higher in gallbladders with multiple gallstones than with a solitary stone, and overall the mean PG level in mucosa was 12-13 times higher than in the muscle wall. Chromatography of mucosal extracts showed substances indistinguishable from primary PGE and F compounds together with a PGD2-like component. An attempt has been made to relate these findings to the degree of chronic inflammatory cell infiltration and to radiological visualisation at pre-operative cholecystography.
D000328:Adult; D002764:Cholecystitis / Q000378:metabolism*; D002765:Cholecystography; D002769:Cholelithiasis / Q000378:metabolism; D002845:Chromatography; D002908:Chronic Disease; D005260:Female; D005704:Gallbladder / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000378:metabolism; D009132:Muscles / Q000378:metabolism; D011453:Prostaglandins / Q000302:isolation & purification / Q000378:metabolism*; D011458:Prostaglandins E / Q000302:isolation & purification / Q000378:metabolism; D011460:Prostaglandins F / Q000302:isolation & purification / Q000378:metabolism
D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F