Tissue blood flow in brain, liver, renal cortex, and renal medulla in experimental hemorrhagic shock.
Cerebral, hepatic, renal cortical, and medullary tissue blood flows of the dog during hemorrhagic shock were measured continuously using the thermoelectrical method. The effects of blood replacement, adrenergic alpha-stimulator and -blockade and hydrocortisone on the tissue blood flows were studied. After hemorrhage, cerebral blood flow was well maintained while renal cortical blood flow was poorly maintained. Following retransfusion, the blood flow returned rapidly to the brain and slowly to the renal cortex. Norepinephrine, phentolamine, and hydrocortisone were not effective in maintaining the organ blood flows in shock. However, when norepinephrine was given systemically and phentolamine administered to the renal artery simultaneously during shock, both cerebral and renal flows were well maintained. After the blood replacement and administration of alpha-blockade or hydrocortisone, all the measured blood flows returned to normal levels.
D000818:Animals; D001794:Blood Pressure; D001804:Blood Transfusion, Autologous; D002560:Cerebrovascular Circulation; D004285:Dogs; D006854:Hydrocortisone / Q000627:therapeutic use; D007668:Kidney / Q000098:blood supply*; D007672:Kidney Cortex / Q000098:blood supply*; D007679:Kidney Medulla / Q000098:blood supply*; D008102:Liver Circulation; D009638:Norepinephrine / Q000008:administration & dosage / Q000627:therapeutic use; D010646:Phentolamine / Q000008:administration & dosage / Q000627:therapeutic use; D012039:Regional Blood Flow; D012771:Shock, Hemorrhagic / Q000188:drug therapy / Q000503:physiopathology*; D014554:Urination
D006854:Hydrocortisone; D009638:Norepinephrine; D010646:Phentolamine