title: [A case of fish tape-worm infection treated with paromomycin and an observation on its mode of action. II. With special reference to aminosidine (author's transl)].
abstract: A female adult suffering from fish tape-worm infection was successfully treated with a single oral administration of 4,000 mg aminosidine, a paromomycin. The drug concentration in the segments of the worm removed were as high as 600 mg/ml or more, meanwhile, serum level and urinary recovery in the patient were very low. Consequently, it was presumed that some acute effect, such as neuro-muscular toxicity, of the drug, which was well absorbed into parasite, but ill-absorbed from the gastrointestinal tract of human, is one of the mode of antihelminthic activity, in this case.
mesh_terms: D002590:Cestode Infections / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010303:Paromomycin / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use*
chemical_list: D010303:Paromomycin