[Host-tumour relationships and immediate hypersensitivity reactions].
When radiolabelled lymphoid cells and the extracellular dye Lissamine green were injected IV into C3H mice carrying non-necrotic methylcholanthrene-induced tumours, the tumour content of these agents was significantly lower than in other organs. The tumour content of these circulating blood components was significantly increased by the intratumoral (IT) induction of local passive anaphylactic reactions, and such reactions exerted an anti-tumour effect, and enhanced the therapeutic activity of IT BCG. No anti-tumour IgE antibody was detected in this model, but the tumour inhibited passive and active anaphylactic reactions in its host.
D000818:Animals; D005354:Fibrosarcoma / Q000209:etiology / Q000276:immunology*; D006969:Hypersensitivity, Immediate / Q000276:immunology*; D007275:Injections, Intravenous; D008086:Lissamine Green Dyes / Q000008:administration & dosage; D008214:Lymphocytes; D008748:Methylcholanthrene; D051379:Mice; D008809:Mice, Inbred C3H
D008086:Lissamine Green Dyes; D008748:Methylcholanthrene
Rapports hote-tumeurs et réactions d'hypersensibilité immédiate