A new aminoglycoside antibiotic complex--the seldomycins. I. Taxonomy, fermentation and antibacterial properties.
A soil isolate named Streptomyces hofunensis sp. nov. was found to produce seldomycin factors 1, 2, 3 and 5, new aminoglycoside antibiotics. Taxonomy of the producing organism, a study of cultural conditions for seldomycin production, and antibacterial activity of seldomycins are reported. Seldomycin factor 5 was the most active both in vitro and in vivo against gram-positive and negative bacteria.
D000617:Aminoglycosides / Q000096:biosynthesis / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000494:pharmacology / Q000633:toxicity; D001419:Bacteria / Q000187:drug effects*; D002244:Carbon / Q000378:metabolism; D003470:Culture Media; D005285:Fermentation; D005839:Gentamicins / Q000494:pharmacology / Q000633:toxicity; D007612:Kanamycin / Q000494:pharmacology / Q000633:toxicity; D007928:Lethal Dose 50; D051379:Mice; D008826:Microbial Sensitivity Tests; D009584:Nitrogen / Q000378:metabolism; D013302:Streptomyces / Q000145:classification / Q000378:metabolism*; D013997:Time Factors
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D003470:Culture Media; D005839:Gentamicins; D007612:Kanamycin; D002244:Carbon; D009584:Nitrogen