Exercise-induced asthma and doxantrazole.
In a double-blind cross-over trial in 13 patients with exercise-induced asthma, doxantrazole 200 mg taken orally 1 hour before a standardized exercise test involving stair climbing failed to block post-exercise bronchoconstriction. In an open assessment study with the same patients, increasing the doxantrazole dose to 400 mg did not affect post-exercise bronchoconstriction.
D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D005260:Female; D006633:Histamine Antagonists / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010366:Peak Expiratory Flow Rate; D005082:Physical Exertion; D013777:Tetrazoles / Q000627:therapeutic use; D013892:Thioxanthenes / Q000627:therapeutic use*; D013997:Time Factors
D006633:Histamine Antagonists; D013777:Tetrazoles; D013892:Thioxanthenes