Preferential uptake of 14c-alpha-aminoisobuturic acid into mouse uterine tissue during early pregnancy.
The uptake of 14C-AIB into uterine tissue and some other organs was studied during early implantation. Mice in experimentally delayed implantation were given estrogen and 14C-AIB at different time intervals. Mice in delayed implantation given only 14C-AIB displayed a low transport rate into the uterine tissue, comparable with that for the diaphragm muscle. However, if the estrogen injection preceeded that of the 14C-AIB by 4 to 8 h the transport capacity increased by a factor of at least 4 times while the uptake for the diaphargm muscle remained low. Under such conditions 14C-AIB-accumulation into uterine tissue was favoured for at least 4 h of in vivo incubation with the labeled amino acid.
D000621:Aminoisobutyric Acids / Q000097:blood / Q000378:metabolism* / Q000652:urine; D000818:Animals; D001921:Brain / Q000378:metabolism; D010065:Embryo Implantation, Delayed / Q000187:drug effects; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D051379:Mice; D009132:Muscles / Q000378:metabolism; D011247:Pregnancy; D011374:Progesterone / Q000494:pharmacology; D011409:Propylene Glycols / Q000494:pharmacology; D014599:Uterus / Q000378:metabolism*
D000621:Aminoisobutyric Acids; D011409:Propylene Glycols; D011374:Progesterone; D004958:Estradiol