title: Failure to elicit conditioned taste aversion by severe poisoning.
abstract: In an attempt to assess the universal validity of the conditioned taste aversion (CTA) paradigm, various types of poisoning (UC) were associated with the gustatory CS. Water deprived rats were habituated for two days to the drinking box, where water was available for 15 min. On Day 3, access to the CS (0.1% saccharin 15 min) was followed after 30 min by a sublethal dose of the poison (0.15 M LiCl, 4% body weight; 0.1 M sodium malonate, 1% body weight; pyrrolopyrimidine drug BW 58-271, 15 mg/kg; sodium cyanide 4 mg/kg; sodium iodoacetate 40 mg/kg; sodium fluoride 30 mg/kg; gallamine triethiodide 40 mg/kg). Rats injected with the last drug were maintained under artificial respiration until muscular paralysis disappeared. After 4 days of recovery, water deprivation schedule was resumed on Days 8 and 9. During the retention test on Day 10 saccharin consumption dropped by 60% in the LiCl poisoned rats, but not CTA developed in animals poisoned by pyrrolopyrimidine, gallamine, malonate and cyanide. CTA of intermediate intensity was evoked by iodoacetate and fluoride. The absence of CTA was not due to the amnesic effect of poisoning, since LiCl administration to NaCN poisoned rats produced CTA of usual intensity. It is concluded that CTA is not related to the overall severity of poisoning but rather to the effect of the poison on specific interoceptors.
mesh_terms: D000818:Animals; D002712:Chlorides / Q000506:poisoning; D003214:Conditioning, Classical / Q000187:drug effects*; D003486:Cyanides / Q000506:poisoning; D005458:Fluoride Poisoning; D005703:Gallamine Triethiodide / Q000506:poisoning; D007461:Iodoacetates / Q000506:poisoning; D008094:Lithium / Q000506:poisoning; D008297:Male; D008314:Malonates / Q000506:poisoning; D011758:Pyrroles / Q000506:poisoning; D051381:Rats; D013649:Taste / Q000187:drug effects*
chemical_list: D002712:Chlorides; D003486:Cyanides; D007461:Iodoacetates; D008314:Malonates; D011758:Pyrroles; D008094:Lithium; D005703:Gallamine Triethiodide