Possible storage of (+)-amphetamine in catecholaminergic terminals of the striatum and brainstem.
6-Hydroxydopamine, given intraventricularly, did not affect the high concentrations of (+)-amphetamine present in the rat striatum and brainstem 1 h after its administration but considerably reduced the small amounts of (+)-amphetamine remaining after 5 h. In contrast, 5,6-dihydroxytryptamine did not modify the (+)-amphetamine concentrations at the times tested. These findings suggest that (+)-amphetamine might be stored in the catecholaminergic but not in the serotonergic central terminals.
D015115:5,6-Dihydroxytryptamine / Q000494:pharmacology; D000818:Animals; D001933:Brain Stem / Q000378:metabolism / Q000648:ultrastructure*; D002395:Catecholamines / Q000502:physiology*; D003342:Corpus Striatum / Q000378:metabolism / Q000648:ultrastructure*; D003913:Dextroamphetamine / Q000378:metabolism*; D005260:Female; D006892:Hydroxydopamines / Q000494:pharmacology; D009411:Nerve Endings / Q000378:metabolism* / Q000502:physiology; D051381:Rats
D002395:Catecholamines; D006892:Hydroxydopamines; D003913:Dextroamphetamine; D015115:5,6-Dihydroxytryptamine