Cytotoxic and radiosensitizing effects of 5-thio-D-glucose on hypoxic cells.
The effect of 5-thio-D-glucose on the viability and radiosensitivity of P815-X2 mouse mastocytoma cells was studied in vitro. By itself, this compound is specifically cytotoxic toward hypoxic cells; moreover, it sensitizes hypoxic cells to irradiation while it protects aerobic cells from radiation damage. These features, together with its low toxicity, suggest that 5- thio-D-glucose may be useful adjuvant to radiotherapy
D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured / Q000187:drug effects / Q000528:radiation effects; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D005947:Glucose / Q000031:analogs & derivatives* / Q000494:pharmacology; D010100:Oxygen; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D013997:Time Factors
D011838:Radiation-Sensitizing Agents; D005947:Glucose; D010100:Oxygen