Influence of imipramine and various steroids on hepatic in vitro N-demethylation of tricyclic antidepressants.
The effects of equimolar doses of imipramine (IP) and three catatoxic steroids, pregnenolone-16alpha-carbonitrile (PCN), spironolactone (SNL) and dexamethasone (DEXA), on hepatic mixed-function oxidases were investigated in female rats. Liver weight and N-demethylation of IP and amitriptyline (AMI) were significantly increased by 3 days of catatoxic steroid pretreatment. Repeated prior administration of IP enhanced N-demethylase activity and 9000g supernate protein, but diminished hepatic weight.
D000639:Amitriptyline / Q000378:metabolism; D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000378:metabolism*; D003640:Dealkylation; D003907:Dexamethasone / Q000494:pharmacology; D005260:Female; D007099:Imipramine / Q000378:metabolism / Q000494:pharmacology*; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D009929:Organ Size / Q000187:drug effects; D011278:Pregnanes / Q000494:pharmacology*; D011285:Pregnenolone Carbonitrile / Q000494:pharmacology; D051381:Rats; D013148:Spironolactone / Q000494:pharmacology
D000929:Antidepressive Agents, Tricyclic; D011278:Pregnanes; D011285:Pregnenolone Carbonitrile; D000639:Amitriptyline; D013148:Spironolactone; D003907:Dexamethasone; D007099:Imipramine