[Basic peptides in bee venom, III. Synthesis of peptide fragments from the sequence of the mast-cell-degranulating peptide (author's transl)].
The synthesis by conventional methods of the following three peptides is described: MCD(8-11) Boc-His(Trt)-Val-Ile-Lys(Z) (III) MCD(5-7) Boc-Cys(SiPr)-Lys(Z)-Arg(Tos) (IV) and MCD(1-4) Boc-Ile-Lys(Z)-Cys(Trt)-Asn(Mbh) (V). These peptides are fragments of the mast cell degranulating peptide from bee venom. The purity of the fragments synthesized was examined by thin-layer chromatography, amino acid and elementary analysis. Including the fragments Boc-Lys(Z)-Ile-Cys(SiPr)-Gly-Lys(Z) (I) and Boc-Pro-His(Trt)-Ile-Cys(Trt)-Arg(Tos) (II), which were described earlier, the synthesis of the mast-cell-degranulating peptide on a polyethylene-asparagine support appears possible.
D000595:Amino Acid Sequence; D000818:Animals; D001516:Bees; D008407:Mast Cells / Q000187:drug effects*; D009904:Optical Rotation; D010455:Peptides / Q000138:chemical synthesis / Q000494:pharmacology; D014688:Venoms / Q000494:pharmacology
D010455:Peptides; D014688:Venoms; C008331:mast cell degranulating peptide
Basische Peptide des Bienengifts, III Synthese von Peptidfragmenten aus der Sequenz des Mastzellen-degranulierenden Peptids