[Side effects of nalidixic acid in a patient with severe renal failure. Clinical study and proposal of a pharmacokinetic model].
Side effects due to ingestion of nalidixic acid in a 46 year old patient with phenacetine-induced interstitial nephritis and severe renal failure are reported. This observation underlines the point that, besides the direct neurotoxic effect of nalidixic acid, disturbance of the acid-basic equilibrium could be seen in patients with renal failure in particular. A hypothetical pharmacokinetic model suggests that two metabolites of nalidixic acid could provide enough hydrogen ion to induce acidosis in cases of renal failure.
D000137:Acid-Base Imbalance / Q000139:chemically induced; D001711:Biotransformation; D006801:Humans; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D009268:Nalidixic Acid / Q000009:adverse effects* / Q000378:metabolism; D009395:Nephritis, Interstitial / Q000139:chemically induced / Q000150:complications* / Q000378:metabolism; D010615:Phenacetin / Q000009:adverse effects
D009268:Nalidixic Acid; D010615:Phenacetin
Effets secondaires de l'acide nalidixique chez une patiente atteinte d'insuffisance rénale sévère. Etude clinique et proposition d'un modéle pharmacocinétique