Failure of ascrobic acid to inhibit the metabolic N-oxidation of the bladder carcingen 4-biphenylamine.
The effect of L-ascorbic acid on the in vivo metabolic N-oxidation of the bladder carcinogen 4-biphenylamine has been investigated in the dog. Gas chromatographic analysis of the urines of dogs receiving concomitant oral doses of L-ascorbic acid and 4-biphyenylamine showed no significant difference in the N-oxidized metabolites when compared to dogs receiving arylamine alone. The results indicate that pretreatment with large doses of L-ascorbic acid has no effect on the metabolic N-oxidation of 4-biphenylamine or on the urinary concentration of these metabolites. The failure of L-ascrobic acid to lower the urinary concentration of these presumed proximate urinary carcinogens casts doubt on its efficacy in bladder tumor prophylaxis.
D000611:Aminobiphenyl Compounds / Q000378:metabolism* / Q000652:urine; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D002273:Carcinogens / Q000378:metabolism*; D002849:Chromatography, Gas; D003864:Depression, Chemical; D004285:Dogs; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D009603:Nitroso Compounds / Q000652:urine; D010084:Oxidation-Reduction; D001743:Urinary Bladder / Q000187:drug effects*
D000611:Aminobiphenyl Compounds; D002273:Carcinogens; D009603:Nitroso Compounds; D001205:Ascorbic Acid