Synthesis and in vivo antimalarial evaluation of isopropyl [(4-chlorophenyl)amino]iminomethylcarbamimidate.
Isopropyl [(4-chlorophenyl)amino]iminomethylcarbamimidate was synthesized as a potential antimalarial agent. Biological activity was evaluated against Plasmodium lophurae in turkeys. The activity of this compound was compared to its nitrogen isostere, chloroguanide.
D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000627:therapeutic use; D006146:Guanidines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D008289:Malaria, Avian / Q000188:drug therapy; D002727:Proguanil / Q000627:therapeutic use; D013997:Time Factors; D014422:Turkeys
D000962:Antimalarials; D006146:Guanidines; D002727:Proguanil