The effect of dipyridamole on platelet function: correlation with blood levels in man.
1 The effect on platelet functions of dipyridamole (a pyrimido-pyrimidine compound) was compared with a control group of patients taking warfarin. 2 Adhesion, aggregation and platelet factor 4 availability showed a significant decrease in the dypyridamole group. 3 Aggregation and platelet factor 4 showed a significant correlation with blood dipyridamole level. 4 Adhesion, aggregation and platelet factor 4 were reduced below the lower limit of normal at blood dipyridamole levels above 3.5 micronmol/1.
D001792:Blood Platelets / Q000187:drug effects*; D004176:Dipyridamole / Q000097:blood / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D010973:Platelet Adhesiveness / Q000187:drug effects; D010974:Platelet Aggregation / Q000187:drug effects; D010978:Platelet Factor 4 / Q000032:analysis; D014859:Warfarin / Q000494:pharmacology
D010978:Platelet Factor 4; D014859:Warfarin; D004176:Dipyridamole