Immunity to lymphoid tumors in syngeneic mice by immunization with mitomycin C-treated cells.
Immunization of mice with syngeneic mitomycin C-treated lymphoid tumor cells (EL-4 and S49A) conferred a high degree of immunity to transplantation with viable tumor cells in syngeneic animals. The development of this immunity was paralleled by the development of specific cell-mediated cytotoxicity; no anti-tumor antibodies could be detected in the immunized animals. In contrast to the high immunoprophylactic capacity of mitomycin C-treated cells, attempts to utilize these cells for immunotherapy were unsuccessful. Preliminary experiments did not reveal antigenic differences between mitomycin C-treated and untreated tumor cells.
D000818:Animals; D000951:Antigens, Neoplasm / Q000032:analysis; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D007109:Immunity; D007114:Immunization; D007274:Injections, Intraperitoneal; D007945:Leukemia, Lymphoid / Q000276:immunology* / Q000401:mortality / Q000628:therapy; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008937:Mitomycins / Q000494:pharmacology*; D009368:Neoplasm Transplantation
D000951:Antigens, Neoplasm; D008937:Mitomycins