Gastric emptying and secretion in Zollinger-Ellison syndrome.
Gastric emptying and secretion, as well as intragastric volume and composition, were determined simultaneously in three patients with Zollinger-Ellison syndrome and in seven normal subjects. Gastric hypersecretion was observed in patients with Zollinger-Ellison syndrome and in normal subjects receiving pentagastrin. In contrast, the fraction of gastric contents emptied per minute (fractional rate of emptying) was increased in Zollinger-Ellison patients and unchanged or decreased in normal subjects receiving pentagastrin. The increased fractional rate of gastric emptying in patients with Zollinger-Ellison syndrome persisted despite abolition of gastric hypersecretion by metiamide. Thus, the increased fractional gastric emptying seen in patients with Zollinger-Ellison syndrome is not attributable to hypergastrinemia, or to gastric hypersecretion per se. Instead, it appears to be caused by an undefined nervous or humoral factor.
D000328:Adult; D005260:Female; D005750:Gastric Juice / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism; D006801:Humans; D008297:Male; D008433:Mathematics; D008722:Methods; D008785:Metiamide / Q000494:pharmacology; D008875:Middle Aged; D010418:Pentagastrin / Q000494:pharmacology; D013270:Stomach / Q000187:drug effects / Q000503:physiopathology*; D014867:Water / Q000378:metabolism; D015043:Zollinger-Ellison Syndrome / Q000378:metabolism / Q000503:physiopathology*
D014867:Water; D008785:Metiamide; D010418:Pentagastrin