[Antagonistic effect of bicuculline and thiosemicarbazide on the tranquilizing effects of diazepam].
It has been shown that bicuculline--GABA-ergic receptors specific blocking agent in doses of 0.5 and 1.0 mg/kg (subcutaneously), and thiosemicarbazide (inhibiting the brain GABA synthesis) in dose of 5.0 and 8.0 mg/kg (subcutaneously) were capable of antagonizing diazepam effects and of reducing its tranquilizing activity in an experimental test of conflict behavior in rats. Bicuculline exhibited a more pronounced antagonism to diazepam than thiosemicarbazide. The data obtained testified to a possible involvement of the GABA-ergic mechanisms in the realization of the anxiolytic effect of benzodiazepines.
D000818:Animals; D001640:Bicuculline / Q000494:pharmacology*; D003220:Conflict, Psychological; D003975:Diazepam / Q000037:antagonists & inhibitors*; D007546:Isoquinolines / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011955:Receptors, Drug / Q000187:drug effects; D012663:Semicarbazides / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D007546:Isoquinolines; D011955:Receptors, Drug; D012663:Semicarbazides; D005680:gamma-Aminobutyric Acid; C005151:thiosemicarbazide; D003975:Diazepam; D001640:Bicuculline
Antagonisticheskoe vliianie bikukullina i tiosemikarbazida na trankviliziruiushchie éffekty diazepama