Anti leukemia activity (L1210) of 6-mercaptopurine and its metallo complexes in mice.
Six-mercaptopurine in the free form and complexed with Pt, Pd, or Bi metals was used at various dosage levels to treat L1210 leukemia in mice. Anticarcinogenic activity was shown by six-mercaptopurine and the Pd and Bi complexes, inactivity by the Pt complex, and toxicity by the highest dosage level of six-mercaptopurine.
D000818:Animals; D001729:Bismuth; D007939:Leukemia L1210 / Q000188:drug therapy*; D015122:Mercaptopurine / Q000627:therapeutic use*; D051379:Mice; D008815:Mice, Inbred Strains; D009942:Organometallic Compounds / Q000627:therapeutic use*; D010165:Palladium; D010984:Platinum
D009942:Organometallic Compounds; D010984:Platinum; D010165:Palladium; D015122:Mercaptopurine; D001729:Bismuth