Nitrophenylated derivatives of epsilon-aminocaproic acid: synthesis and physico-chemical characterization.
Methods for the synthesis of the mono-, di- and tri-nitro derivatives of epsilon-aminocaproic acid are presented. Special attention is given to the purification procedure, as we have found that methods recommended in the literature do not produce a single product. Evidence is presented which shows that recrystallizing the haptens from hot ethanol produces a by-product which is the ethyl ester of the haptens. Characterization methods and physical properties of the nitro-phenylated derivates of epsilon-aminocaproic acid are summarized.
D000614:Aminocaproates / Q000138:chemical synthesis*; D015119:Aminocaproic Acid / Q000138:chemical synthesis*; D004139:Dinitrofluorobenzene / Q000031:analogs & derivatives; D008722:Methods; D009578:Nitrobenzenes / Q000138:chemical synthesis; D010853:Picryl Chloride; D013053:Spectrophotometry
D000614:Aminocaproates; D009578:Nitrobenzenes; D004139:Dinitrofluorobenzene; D015119:Aminocaproic Acid; D010853:Picryl Chloride