title: Effects of catecholamines and their inhibitors on the isolated canine pancreas. I. Noradrenaline and isoprenaline.
abstract: alpha Adrenergic agonist (noradrenaline, 2, 20, and 200 mug) and antagonist (phenoxybenzamine, 15 mg), and beta adrenergic agonist (isoproterenol, 2, 20, and 200 mug), and antagonist (propranolol, 6 mg), were tested on isolated perfused canine pancreas under basal conditions, and under stimulation by a background of secretin (0.5 clinical unit per hr), or of caerulein (600 to 1200 ng per hr). Noradrenaline induced a strong vasoconstriction (inhibited by phenoxybenzamine), followed by a moderate vasodilation (possibly mechanical). Noradrenaline did not stimulate a resting pancreas and inhibited a pancreas from secreting in response to secretin or caerulein. After phenoxybenzamine, in the absence of vasoconstriction, this latter effect was reversed into a dose-dependent stimulation of hydrelatic secretion, suggesting that noradrenaline had a direct action on the secretory cell. There was no stimulation of protein and no acinar degranulation. Propranolol and atropine did not modify the effectiveness of noradrenaline. Isoprenaline had a weak vasodilatory effect but no effect on the secretion. Adrenergic blocking agents did not alter the response to secretin or caerulein.
mesh_terms: D000818:Animals; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D007545:Isoproterenol / Q000494:pharmacology*; D009638:Norepinephrine / Q000494:pharmacology*; D010179:Pancreas / Q000098:blood supply / Q000187:drug effects* / Q000378:metabolism; D010643:Phenoxybenzamine / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000187:drug effects; D012633:Secretin / Q000494:pharmacology; D013268:Stimulation, Chemical; D014655:Vascular Resistance / Q000187:drug effects; D014666:Vasomotor System / Q000187:drug effects
chemical_list: D010643:Phenoxybenzamine; D012633:Secretin; D011433:Propranolol; D007545:Isoproterenol; D009638:Norepinephrine