[Changes in insulin (IRI) and NEFA levels in diabetic subjects after acute intravenous glipizide and tolbutamide administration].
Glypizide and i.v. tolbutamide were administered to a series of diabetics. On different days, 10 subjects (controls for themselves) received 1 mg glypizide anal 100 mg tolbutamide; a further 10 received 2 mg glypizide and 200 mg tolbutamide. Blood sugar and insulin and NEFA values were determined every 10' for one hour after the injection. It was found that the hypoglycaemising activity of glypizide was about 140 times that of tolbutamide. It also caused a greater incretion of insuline and a more marked reduction of NEFA.
D000368:Aged; D000941:Antigens / Q000032:analysis; D003920:Diabetes Mellitus / Q000097:blood*; D004341:Drug Evaluation; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005260:Female; D005913:Glipizide / Q000494:pharmacology*; D006801:Humans; D007328:Insulin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D013453:Sulfonylurea Compounds / Q000494:pharmacology*; D014044:Tolbutamide / Q000494:pharmacology*
D000941:Antigens; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D013453:Sulfonylurea Compounds; D014044:Tolbutamide; D005913:Glipizide
Modificazioni dei tassi insulinico (IRI) e dei NEFA in soggetti diabetici dopo carico acuto endovenoso di glipizide e di tolbutamide