Accentuation of ethanol-induced fatty liver by phenobarbitone.
1. Four groups of rats received a liquid formula diet, given alone (control), or supplemented with either ethanol or phenobarbitone, or both together. 2. The ethanol-treated group showed a fall in plasma triglyceride and a rise in liver triglyceride, as compared with the control rats. 3. The phenobarbitone-treated group showed a marked rise in plasma triglyceride but not in liver triglyceride. 4. The group receiving both ethanol and phenobarbitone also showed a rise in plasma triglyceride, but this was accompanied by a striking increase in liver triglyceride. 5. These results suggest that ethanol and phenobarbitone each stimulate triglyceride synthesis but that in addition ethanol has an inhibitory effect on hepatic triglyceride secretion.
D000818:Animals; D002784:Cholesterol / Q000378:metabolism; D004357:Drug Synergism; D000431:Ethanol / Q000633:toxicity*; D005234:Fatty Liver / Q000139:chemically induced*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D010634:Phenobarbital / Q000633:toxicity*; D051381:Rats; D014280:Triglycerides / Q000096:biosynthesis
D014280:Triglycerides; D000431:Ethanol; D002784:Cholesterol; D010634:Phenobarbital