[Abnormal specificities of immune alloantisera].
Sera from repeatedly immunized with allogenic lymphocytes contain IgG that can be fixed by syngenic tumour cells. When compared to the specific anti-H-2 immune response, the paradoxical tumour reactivity is often very high, suggesting an active immunization process. Selective absorptions have demonstrated that the majority of these "anomalous" IgG are directed against membrane components of tumour cells. The nature of the detected tumour-associated determinants is not well elucidated: they are not found on normal embryonnic or adult tissue, but are highly expressed by all in vitro murine malignant cell lines thus far tested, and to a lesser extent by the corresponding in vitro maintained tumours.
D000818:Animals; D000918:Antibody Specificity; D007106:Immune Sera / Q000032:analysis*; D007074:Immunoglobulin G / Q000378:metabolism; D007518:Isoantibodies; D051379:Mice
D007106:Immune Sera; D007074:Immunoglobulin G; D007518:Isoantibodies
Spécificités sérologiques  "anormales" des immunsérums allogéniques