Estrogen potentiating activity of two spiro compounds having approximately similar molecular dimensions to stilbestrol.
Pharmacological investigation of members of a series of synthetic spiro derivatives with similar molecular dimensions to stilbestrol revealed that two compounds, spiro[cyclohexane-1,2'-tetralin]-1,4'-dione and spiro[cyclohexane-1,2'-indan]-1,4'-diol, exhibited a marked ability to potentiate stilbestrol at doses which had no intrinsic estrogenic activity. It is postulated that such compounds may be of use in reducing the side effects associated with estrogen therapy.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D004054:Diethylstilbestrol / Q000494:pharmacology*; D004357:Drug Synergism; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D009929:Organ Size / Q000187:drug effects; D013141:Spiro Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D014599:Uterus / Q000033:anatomy & histology / Q000187:drug effects
D013141:Spiro Compounds; D004054:Diethylstilbestrol