title: Insecticide solvents: interference with insecticidal action.
abstract: Several commercial solvent mixtures commonly used as insecticide carriers in spray formulations increase by more than threefold the microsomal N-demethylation of p-chloro N-methylaniline in midgut preparations of southern army-worm (Spodoptera eridania) larvae exposed orally to the test solvents. Under laboratory conditions, the same solvent mixtures exhibit a protective action against the in vivo toxicity of the insecticide carbaryl to the larvae. The data are discussed with respect to possible solvent-insecticide interactions occurring under field conditions and, more broadly, to potential toxicological hazards of these solvents to humans.
mesh_terms: D004790:Enzyme Induction; D007306:Insecticides / Q000378:metabolism / Q000633:toxicity; D007915:Lepidoptera / Q000187:drug effects*; D008861:Microsomes / Q000201:enzymology; D009036:Moths / Q000187:drug effects* / Q000201:enzymology; D010089:Oxidoreductases, N-Demethylating / Q000378:metabolism*; D012997:Solvents / Q000494:pharmacology*
chemical_list: D007306:Insecticides; D012997:Solvents; D010089:Oxidoreductases, N-Demethylating