The 6-ketoprostaglandin F1alpha pathway in the lamb ductus arteriousus.
Homogenates of the lamb ductus arteriosus at term have the capacity to convert exogenous arachidonic acid into prostaglandins E2, F2alpha and 6-ketoprostaglandin F1alpha. No evidence was obtained for the formation of prostaglandin D2 and thromboxane B2. All products were quantitated by mass spectrometry. 6-Ketoprostaglandin F1alpha was the major compound, formed in amounts in excess of 10 fold over prostalgandins E2 and F2alpha.
D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism; D004373:Ductus Arteriosus / Q000378:metabolism*; D005260:Female; D005333:Fetus / Q000378:metabolism; D011247:Pregnancy; D011453:Prostaglandins / Q000096:biosynthesis; D011458:Prostaglandins E / Q000096:biosynthesis; D011460:Prostaglandins F / Q000096:biosynthesis*; D012756:Sheep
D001095:Arachidonic Acids; D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F