Catecholaminergic involvement in the effects of amphetamine isomers on seizure susceptibility.
The (+)-amphetamine (2.5 mg/kg) increase in pentylenetetrazol seizure was abolished by pretreatment with reserpine, alpha-methyltyrosine methyl ester (alpha-MT), FLA-63 or 6-hydroxydopa. All treatments except reserpine antagonized the increase in seizure threshold produced by (-)-amphetamine (4 mg/kg). Only reserpine +alpha-MT antagonized the decrease in seizure threshold produced by (+)-amphetamine (15 mg/kg). These results indicate that amphetamine alterations in PTZ seizure susceptibility are mediated indirectly via the release of newly synthetized and/or granular stores of catecholamines.
D000661:Amphetamine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000818:Animals; D005406:Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide / Q000494:pharmacology; D001921:Brain / Q000378:metabolism; D002395:Catecholamines / Q000096:biosynthesis*; D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives / Q000494:pharmacology; D008297:Male; D008781:Methyltyrosines / Q000031:analogs & derivatives / Q000494:pharmacology; D051379:Mice; D010433:Pentylenetetrazole / Q000494:pharmacology; D012110:Reserpine / Q000494:pharmacology; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology*; D013237:Stereoisomerism
D002395:Catecholamines; D008781:Methyltyrosines; D005406:Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; D004295:Dihydroxyphenylalanine; D012110:Reserpine; D000661:Amphetamine; D010433:Pentylenetetrazole