title: In vitro and in vivo studies of extrapineal N-acetyltransferase of rat brain.
abstract: In a series of experiments, extrapineal rat brain N-acetyltransferase was further characterized and was demonstrated to have a similar pH optimum and similar activity to that of the low activity daytime pineal N-acetyltransferase. Experiments in vivo indicate that N-acetylation may be a possible alternative metabolic pathway for biogenic amines and that brain N-acetyltransferase activity may be regulated by a beta-adrenergic mechanism.
mesh_terms: D000107:Acetylation; D000123:Acetyltransferases / Q000097:blood / Q000378:metabolism*; D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism; D001773:Blood Cells / Q000201:enzymology; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D002394:Catechol O-Methyltransferase / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007490:Iproniazid / Q000494:pharmacology; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism; D010870:Pineal Gland / Q000187:drug effects / Q000201:enzymology*; D051381:Rats; D013997:Time Factors; D014334:Tropolone / Q000494:pharmacology
chemical_list: D001679:Biogenic Amines; D014334:Tropolone; D007490:Iproniazid; D008995:Monoamine Oxidase; D002394:Catechol O-Methyltransferase; D000123:Acetyltransferases; D007545:Isoproterenol