title: Effect of cholecystokinin on myoelectric activity of small bowel of the dog.
abstract: The effect of cholecystokinin on the myoelectric activity of the small intestine was determined in conscious dogs. Six animals were implanted with electrodes along the small intestine, and a cannula was placed in the stomach. A second cannula was inserted into the duodenum in three animals, and a pancreatic fistula was prepared in three animals. Recordings were made in the fasted state, during the intravenous infusion of either saline or cholecystokinin-octapeptide (CCK-OP), during the intraduodenal infusion of either saline or L-tryptophan, and during the fed state. CCK-OP disrupted the fasted pattern of myoelectric activity, caused a dose-dependent increase in spike potentials, and caused a dose-dependent increases in pancreatic protein secretion. Stimulation of myoelectric activity occurred at doses that produced submaximal protein secretion; however, the stimulation was not identical to that seen with feeding. Intraduodenal infusion of L-tryptophan increased pancreatic protein secretion, interrupted the fasted pattern of motility, and induced a pattern similar to that seen with feeding. We conclude that CCK alters small intestinal motility and may play a role in the changes in small-bowel motility caused by the ingestion of food.
mesh_terms: D000200:Action Potentials / Q000187:drug effects*; D000818:Animals; D002766:Cholecystokinin / Q000378:metabolism / Q000494:pharmacology*; D004285:Dogs; D004567:Electrodes, Implanted; D005215:Fasting; D007421:Intestine, Small / Q000502:physiology; D009130:Muscle, Smooth / Q000502:physiology*; D014364:Tryptophan / Q000494:pharmacology
chemical_list: D014364:Tryptophan; D002766:Cholecystokinin