title: Effect of biguanide treatment in obese children.
abstract: In seven children of normal weight and in nine obese children (more than 30% overweight) from 8 to 14 years of age, blood glucose and insulin levels were estimated. The obese children were then treated with dimethylbiguanide (Metformin-HCl) during 3 months. After this period the tests were repeated. It is shown that a significant reduction of the insulin values, insulinogen indices and weight occurred after this treatment.
mesh_terms: D000293:Adolescent; D001786:Blood Glucose / Q000032:analysis; D002648:Child; D005215:Fasting; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood*; D008687:Metformin / Q000627:therapeutic use*; D009765:Obesity / Q000188:drug therapy*
chemical_list: D001786:Blood Glucose; D007328:Insulin; D008687:Metformin