title: Development of the geniculocortical pathway in rats.
abstract: Most cell of the dorsal laterial geniculate nucleus of rats are generated on fetal days 12 to 14. Their axons invade the telencephalon on fetal day 16 and run in the intermediate zone just below the cortical plate, reaching the visual area of fetal day 18. The axons do not invade the cortical plate significantly until close to birth (day 22 of gestation) and reach  their zone of terminal distribution between postnatal days 1 and 4. In subsequent days the projection becomes progressively more heavily distrubuted in layers IV and I, and synapses of thalamic origin can be identified in these layers. While cells destined for layers IV cross the intermediate zone at the time that thalamic axons first arrive, this coincidence of growth does not seem to be a factor which determines the specificity of patterns of thalamocortical connections since the cells reach layer IV several days before the axons. It is unclear why the axons should wait several days in the region immediately below the cortical plate before invading; although there is a parallel in previous studies on the development of the chick retinotectal pathway (Crossland et al., '75).
mesh_terms: D000367:Age Factors; D000818:Animals; D005829:Geniculate Bodies / Q000166:cytology* / Q000196:embryology / Q000254:growth & development; D051381:Rats; D014793:Visual Cortex / Q000166:cytology* / Q000196:embryology / Q000254:growth & development; D014795:Visual Pathways / Q000166:cytology* / Q000196:embryology / Q000254:growth & development