title: Indolizine derivatives with biological activity I: N'-substituted hydrazides of indolizine-2-carboxylic acid.
abstract: The synthesis and antimonoamine oxidase activity of some N'-substituted hydrazides of indolizine-2-carboxylic acid are described. They all inhibit monoamine oxidase and are more active than iproniazid. The structure-activity relationships also are discussed.
mesh_terms: D002264:Carboxylic Acids / Q000138:chemical synthesis / Q000494:pharmacology; D066298:In Vitro Techniques; D007212:Indolizines / Q000138:chemical synthesis* / Q000494:pharmacology; D007490:Iproniazid / Q000494:pharmacology; D008996:Monoamine Oxidase Inhibitors / Q000138:chemical synthesis*; D013329:Structure-Activity Relationship
chemical_list: D002264:Carboxylic Acids; D007212:Indolizines; D008996:Monoamine Oxidase Inhibitors; D007490:Iproniazid