Complement in the induction of IgE antibody formation.
The IgE antibody response of NIH mice to ovalbumin was suppressed by in vivo complement depletion with cobra factor. This observation extends to IgE the finding that complement participates in thymus-dependent antibody formation. Control mice producing IgI anti-ovalbumin antibody after boosting all developed marked peripheral eosinophilia, whereas mice in which the IgE antibody response had been suppressed by cobra factor did not. Administration of cobra factor itself had no effect on peripheral eosinophil levels.
D000818:Animals; D000917:Antibody Formation; D003176:Complement C3 / Q000032:analysis; D003165:Complement System Proteins / Q000032:analysis; D007073:Immunoglobulin E / Q000096:biosynthesis*; D051379:Mice; D010047:Ovalbumin / Q000276:immunology; D012910:Snake Venoms / Q000276:immunology
D003176:Complement C3; D012910:Snake Venoms; D007073:Immunoglobulin E; D010047:Ovalbumin; D003165:Complement System Proteins