[Role of genotypic and environmental factors in the origin of cerebral circulatory disorders in young persons].
The paper is concerned with the results of a comparative analysis of clinical signs in cerebral crises, strokes and other symptoms seen in 2 groups of patients younger than 45 years of age, and differing only in the presence (104 cases) or absence (108 cases) of hereditary-familial aggravation by a cardio-vascular pathology. Although in the first group of patients there was a certain tendency towards a more severe disorder of cerebral circulation, it was not possible to mark any statistically significant differences in the clinico-biochemical indices. At the same time different negative environmental influences (alcohol abuse, brain injuries, severe acute and chronic mental traumatization, frequent exacerbations of focal chronic infections of the ENT and the lungs, etc.) and a combination of 2 or 3 of them were significantly more frequently seen in patients without hereditary aggravation (34.8%) rather then with it (10.7%). A conclusion is being made that genotypical factors do not play a decisive role in the etiology of cerebral vascular disorders in young people. They only condition a lesser stability of the organism to unfavourable environmental factors and their different combinations.
D002561:Cerebrovascular Disorders / Q000209:etiology* / Q000235:genetics; D006801:Humans; D008875:Middle Aged
O roli genotipicheskikh i sredovykh faktorov v proiskhozhdenii narusheniĭ mozgovogo krovoobrashcheniia u molodykh liudeĭ