A new cell line from a human chondrosarcoma.
Morphological and growth characteristics are described of a rapidly growing cell line with epithelioid and giant-cell characteristics derived from a chondrosarcoma in a male patient 65 years of age. This cell line is of considerable interest because in these cells cross-reacting antigens with known animal oncorna-viruses are present. Biochemically, the cells contain particles with a density of 1-16 with "cores" of density 1'23 associated with a reverse-transcriptase-like enzyme and with 70S RNA. Occasionally, virus-like particles were demonstrated by electron microscope in material derived from the culture medium.
D000368:Aged; D001859:Bone Neoplasms / Q000276:immunology / Q000473:pathology*; D002460:Cell Line; D002813:Chondrosarcoma / Q000276:immunology / Q000473:pathology*; D002875:Chromosomes; D006801:Humans; D008297:Male; D009858:Oncogenic Viruses / Q000302:isolation & purification; D012328:RNA Viruses / Q000302:isolation & purification