[Effect of several derivatives of ortho-hydroxybenzoic acid on the glutamate and ketoglutarate oxidation activity of rat liver mitochondria].
Tests conducted with isolated hepatic mitochondria showed that introduction of acetylsalicylic acid (ASA) to rats in a dose of 300 mg/kg for 5 and 20 days inhibited the oxidation systems of glutamate and alpha-ketoglutarate. This effect depends on the stationary concentration of the compound in the organism. Thus, administration of a high ASA dose (300 mg/kg) for 5 and 20 days, as well as its single administration in doses of 400 or 600 mg/kg had the effect of persistently suppressing the activity of these systems without causing any changes in the degree of the energy-generating conjugation.
D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D005971:Glutamates / Q000378:metabolism*; D062385:Hydroxybenzoates / Q000494:pharmacology*; D066298:In Vitro Techniques; D007656:Ketoglutaric Acids / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000378:metabolism*; D010084:Oxidation-Reduction; D051381:Rats; D014475:Uncoupling Agents
D005971:Glutamates; D062385:Hydroxybenzoates; D007656:Ketoglutaric Acids; D014475:Uncoupling Agents; D001241:Aspirin
Vliianie nekotorykh proizvodnykh ortooksibenzoĭnoĭ kisloty na aktivnost' okisleniia gliutamata i ketogliutarata mitokhondriiami pecheni krys