Fate of orally dosed linamarin in the rat.
Wistar rats, about 100 g in weight, were dosed by stomach tube with 30 mg of pure linamarin. No intact linamarin was identified in the feces or blood but 5.65 mg was excreted in the urine along with 0.823 mg of thiocyanate ion. A 50-mg dose of linamarin was lethal to 7 of 10 rats receiving this dose.
D000284:Administration, Oral; D000818:Animals; D005960:Glucosides / Q000008:administration & dosage / Q000378:metabolism* / Q000633:toxicity; D006027:Glycosides / Q000378:metabolism*; D006321:Heart / Q000187:drug effects; D008297:Male; D002365:Manihot; D009570:Nitriles / Q000008:administration & dosage / Q000378:metabolism* / Q000633:toxicity; D051381:Rats; D013861:Thiocyanates / Q000652:urine
D005960:Glucosides; D006027:Glycosides; D009570:Nitriles; D013861:Thiocyanates; C005091:linamarin