[Effect of N-nitroso-N'-methylurea on the cellular kinetics in tumors].
Single intrafemoral injection of NMU in the dosage of 80 mg/Kh in mice with ascites leucemia L1210 induced considerable disorders in the tumor cell cycle. The passage of phase S by cells was markedly retarded during the period from 1 hour to 6 days, while after injection of the substance under study a maximum duration of phase G2 increased from 4 to 12 hours. Inhibition of phase S onset was provisional, and already 6 hours following NMU injection all cells entered phase S. In mice mammary tumors the  label index fell markedly (by 90%) during the period from 6 hours to 8 days after NMU injection. The intensity of 3H-thymidine incorporation during the whole period of observation was approximately twice reduced.
D000818:Animals; D002452:Cell Count; D004273:DNA, Neoplasm / Q000096:biosynthesis; D005260:Female; D007700:Kinetics; D007939:Leukemia L1210 / Q000378:metabolism*; D008325:Mammary Neoplasms, Experimental / Q000378:metabolism; D008770:Methylnitrosourea / Q000494:pharmacology*; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008938:Mitosis / Q000187:drug effects; D009607:Nitrosourea Compounds / Q000494:pharmacology*; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors; D014316:Tritium
D004273:DNA, Neoplasm; D009607:Nitrosourea Compounds; D014316:Tritium; D008770:Methylnitrosourea; D013936:Thymidine
Vliianie N-nitrozo-N'-metilmocheviny na kletochnuiu kinetiku v opukholiakh