The effect of (-)-isoprenaline and (+/-)-salbutamol on pepsinogen and acid secretion in the dog.
1 The beta-adrenoceptor agonists, (-)-isoprenaline and (+/-)-salbutamol, reduced pepsinogen secretion induced by pentagastrin in conscious dogs with Heidenhaim pouches. 2 (-)-Isoprenaline and (+/-)-salbutamol also reduced gastric acid secretion while producing a moderate tachycardia.
D000420:Albuterol / Q000494:pharmacology*; D000818:Animals; D003864:Depression, Chemical; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D006339:Heart Rate / Q000187:drug effects; D007545:Isoproterenol / Q000494:pharmacology*; D008297:Male; D010418:Pentagastrin / Q000494:pharmacology; D010435:Pepsinogens / Q000378:metabolism*
D010435:Pepsinogens; D010418:Pentagastrin; D007545:Isoproterenol; D000420:Albuterol