[Investigations on the pharmacokinetics of pentoxifylline in chronic renal failure (authors transl)].
The pharmacokinetical behaviour of 14C-labelled pentoxifylline was investigated in normal volunteers and in patients with different stages of impaired renal function. It was shown that in patients, having a creatinine-clearance of less than 10,0 ml/min., occurs an accumulation of pentoxifylline. This finding leads to the conclusion that in patients with advanced renal failure the daily dose of pentoxifylline should be adjusted to the diminished renal elimination.
D000284:Administration, Oral; D000368:Aged; D003404:Creatinine / Q000378:metabolism; D006801:Humans; D007676:Kidney Failure, Chronic / Q000188:drug therapy / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010431:Pentoxifylline / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D013805:Theobromine / Q000031:analogs & derivatives*
D003404:Creatinine; D013805:Theobromine; D010431:Pentoxifylline
Untersuchungen zur Pharmakokinetik von Pentoxifyllin bei chronischer Niereninsuffizienz