Decidualization and ovum-implantation in spayed mice treated with oestriol.
Single injections of oestriol were partially effective in sensitizing the uterus to a decidual stimulus and inducing ovum-implantation in progesterone-treated spayed mice, whereas two injections (6 h apart) were fully effective. It seems that in the progestational uterus, as in the non-progestational organ, oestriol can induce a full oestrogenic response provided that its level in the target organ is maintained. It is also concluded that ovum-implantation is not triggered by some transient early effect of oestrogen, but requires about 12 h of sustained oestrogen action for its successful completion.
D000818:Animals; D002369:Castration; D003656:Decidua / Q000187:drug effects*; D010064:Embryo Implantation / Q000187:drug effects*; D004958:Estradiol / Q000494:pharmacology; D004964:Estriol / Q000494:pharmacology*; D005260:Female; D051379:Mice; D011247:Pregnancy; D011374:Progesterone / Q000494:pharmacology
D011374:Progesterone; D004958:Estradiol; D004964:Estriol