[An improved exercise test in coronary-heart disease: effect of molsidomin on erogometrically controlled exercise (author's transl)].
The protective effect of molsidomin (N-ethoxycarbonyl-3-morpholinosydnonimine) during ergometric exercise was tested on 40 patients with coronary insufficiency proven by preliminary exercise tests or coronary arteriography. Changes in arterial blood pressure, heart rate, pulmonary artery pressure, ischaemic S-T depression and maximal working capacity were used as criteria. The drug increased maximal working capacity and decreased S-T segment depression. In addition it caused a fall in systolic and diastolic blood pressure and pulmonary artery pressure, at rest and during exercise. Resting heart rate increased slightly but during exercise the heart rate was reduced at comparable load stages. The results suggest that molsidomon may be an effective drug in the treatment of angina pectoris.
D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy; D001794:Blood Pressure / Q000187:drug effects; D003327:Coronary Disease / Q000188:drug therapy* / Q000503:physiopathology; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009025:Morpholines / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D010069:Oxadiazoles / Q000627:therapeutic use*; D005082:Physical Exertion; D011651:Pulmonary Artery; D013558:Sydnones / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*
D009025:Morpholines; D010069:Oxadiazoles; D013558:Sydnones
Zur Verbesserung der Arbeitsbelastung Koronarkranker. Wirkung von Molsidomin auf die ergometrisch gemessene Arbeitstoleranz