Inhibition of virus-induced plaque formation by atoxic derivatives of purified cobra neurotoxins.
Venom from Naja naja siamensis was resolved into 16 toxic and nontoxic fractions by chromatography on SP-Sephadex, C-25. The principal neurotoxin preparations were chromatographically and electrophoretically homogeneous. Of the purified constituents, only the principal neurotoxin and minor neurotoxins were precursors of inhibitors of plaque formation among baby hamster kidney fibroblasts infected with Semliki Forest Virus.
D002460:Cell Line; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects*; D003864:Depression, Chemical; D010084:Oxidation-Reduction; D012672:Semliki forest virus / Q000187:drug effects*; D012910:Snake Venoms / Q000032:analysis / Q000494:pharmacology* / Q000633:toxicity; D013329:Structure-Activity Relationship; D010948:Viral Plaque Assay
D012910:Snake Venoms