title: Morphine, naloxone and the responses of medial thalamic neurones of the cat.
abstract: Administered electrophoretically morphine depressed the firing of medial thalamic neurones. This effect was not antagonized by naloxone which itself was a depressant. A long lasting increase in sensitivity to L-glutamate followed ejection of both morphine and naloxone. Intravenous morphine, 0.5-1.5 mg/kg, had inconstant effects on spontaneous firing that evoked by electrical stimulation of the forepaws but in 7 of 10 experiments reduced the sensitivity of neurones to L-glutamate. This effect was reversed in all cases by intravenous naloxone, 0.3 mg/kg
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002415:Cats; D003864:Depression, Chemical; D004347:Drug Interactions; D005071:Evoked Potentials / Q000187:drug effects; D005971:Glutamates / Q000494:pharmacology; D009020:Morphine / Q000008:administration & dosage / Q000494:pharmacology*; D009270:Naloxone / Q000008:administration & dosage / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects; D013788:Thalamus / Q000166:cytology / Q000187:drug effects*
chemical_list: D005971:Glutamates; D009270:Naloxone; D009020:Morphine; D000109:Acetylcholine