Analysis of pregnanediol in urine: trental interference.
Patients given Trental (pentoxifyllin, Hoechst A.G.) for the treatment of vascular disorders excrete a substance which interferes with the gas chromatographic anlaysis of pregnanediol. The interfering substance appeared in urine within 4-5 h of the ingestion of 100 mg Trental, and was cleared during the next 4-10 h. The administration of 300 mg/24 h to an anovulatory woman caused an apparent increase in her output of pregnanediol of from less than 1 to 65.8 micronmol/24 h.
D002849:Chromatography, Gas; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010431:Pentoxifylline / Q000652:urine*; D011276:Pregnanediol / Q000652:urine*; D013805:Theobromine / Q000031:analogs & derivatives*; D013997:Time Factors
D011276:Pregnanediol; D013805:Theobromine; D010431:Pentoxifylline